Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.
Works about studies that are usually controlled to assess the effectiveness and dosage (if appropriate) of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques. These studies are performed on several hundred volunteers, including a limited number of patients with the target disease or disorder, and last about two years. This concept includes phase II studies conducted in both the U.S. and in other countries.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as RANDOMIZED CONTROLLED TRIALS AS TOPIC.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.
Elements of limited time intervals, contributing to particular results or situations.
Planned post-marketing studies of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale. These studies are often conducted to obtain additional data about the safety and efficacy of a product. This concept includes phase IV studies conducted in both the U.S. and in other countries.
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
Committees established to review interim data and efficacy outcomes in clinical trials. The findings of these committees are used in deciding whether a trial should be continued as designed, changed, or terminated. Government regulations regarding federally-funded research involving human subjects (the "Common Rule") require (45 CFR 46.111) that research ethics committees reviewing large-scale clinical trials monitor the data collected using a mechanism such as a data monitoring committee. FDA regulations (21 CFR 50.24) require that such committees be established to monitor studies conducted in emergency settings.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Precise and detailed plans for the study of a medical or biomedical problem and/or plans for a regimen of therapy.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.
A publication issued at stated, more or less regular, intervals.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Earlier than planned termination of clinical trials.
Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.
Therapy with two or more separate preparations given for a combined effect.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
The number of units (persons, animals, patients, specified circumstances, etc.) in a population to be studied. The sample size should be big enough to have a high likelihood of detecting a true difference between two groups. (From Wassertheil-Smoller, Biostatistics and Epidemiology, 1990, p95)
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Published materials which provide an examination of recent or current literature. Review articles can cover a wide range of subject matter at various levels of completeness and comprehensiveness based on analyses of literature that may include research findings. The review may reflect the state of the art. It also includes reviews as a literary form.
A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.
Persons who are enrolled in research studies or who are otherwise the subjects of research.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.
The teaching or training of patients concerning their own health needs.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
Activities performed to identify concepts and aspects of published information and research reports.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
Establishment of the level of a quantifiable effect indicative of a biologic process. The evaluation is frequently to detect the degree of toxic or therapeutic effect.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.
Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.
The giving of drugs, chemicals, or other substances by mouth.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Financial support of research activities.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Voluntary cooperation of the patient in following a prescribed regimen.
A subspecialty of internal medicine concerned with the study of neoplasms.
Tumors or cancer of the human BREAST.
Drugs which have received FDA approval for human testing but have yet to be approved for commercial marketing. This includes drugs used for treatment while they still are undergoing clinical trials (Treatment IND). The main heading includes drugs under investigation in foreign countries.
An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.
Patient involvement in the decision-making process in matters pertaining to health.
The return of a sign, symptom, or disease after a remission.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
Method of measuring performance against established standards of best practice.
Conversations with an individual or individuals held in order to obtain information about their background and other personal biographical data, their attitudes and opinions, etc. It includes school admission or job interviews.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
The degree to which the individual regards the health care service or product or the manner in which it is delivered by the provider as useful, effective, or beneficial.
Human experimentation that is intended to benefit the subjects on whom it is performed.
Strategy for the analysis of RANDOMIZED CONTROLLED TRIALS AS TOPIC that compares patients in the groups to which they were originally randomly assigned.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Antibodies produced by a single clone of cells.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
An operating division of the US Department of Health and Human Services. It is concerned with the overall planning, promoting, and administering of programs pertaining to health and medical research. Until 1995, it was an agency of the United States PUBLIC HEALTH SERVICE.
Tumors or cancer of the LUNG.
Use of plants or herbs to treat diseases or to alleviate pain.
Any deviation of results or inferences from the truth, or processes leading to such deviation. Bias can result from several sources: one-sided or systematic variations in measurement from the true value (systematic error); flaws in study design; deviation of inferences, interpretations, or analyses based on flawed data or data collection; etc. There is no sense of prejudice or subjectivity implied in the assessment of bias under these conditions.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Discontinuance of care received by patient(s) due to reasons other than full recovery from the disease.
Instruction in which learners progress at their own rate using workbooks, textbooks, or electromechanical devices that provide information in discrete steps, test learning at each step, and provide immediate feedback about achievement. (ERIC, Thesaurus of ERIC Descriptors, 1996).
Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
Those individuals engaged in research.
Disorders that result from the intended use of PHARMACEUTICAL PREPARATIONS. Included in this heading are a broad variety of chemically-induced adverse conditions due to toxicity, DRUG INTERACTIONS, and metabolic effects of pharmaceuticals.
Disease having a short and relatively severe course.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Societies whose membership is limited to physicians.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Manipulation of the host's immune system in treatment of disease. It includes both active and passive immunization as well as immunosuppressive therapy to prevent graft rejection.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.
The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.
An infant during the first month after birth.
The giving of advice and assistance to individuals with educational or personal problems.
Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Studies designed to assess the efficacy of programs. They may include the evaluation of cost-effectiveness, the extent to which objectives are met, or impact.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Treatments with drugs which interact with or block synthesis of specific cellular components characteristic of the individual's disease in order to stop or interrupt the specific biochemical dysfunction involved in progression of the disease.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Works about books, articles or other publications on herbs or plants describing their medicinal value.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
The influence of study results on the chances of publication and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study findings. Publication bias has an impact on the interpretation of clinical trials and meta-analyses. Bias can be minimized by insistence by editors on high-quality research, thorough literature reviews, acknowledgement of conflicts of interest, modification of peer review practices, etc.
The exchange or transmission of ideas, attitudes, or beliefs between individuals or groups.
Substances that reduce the growth or reproduction of BACTERIA.
Those factors which cause an organism to behave or act in either a goal-seeking or satisfying manner. They may be influenced by physiological drives or by external stimuli.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Hospital or other institutional committees established to protect the welfare of research subjects. Federal regulations (the "Common Rule" (45 CFR 46)) mandate the use of these committees to monitor federally-funded biomedical and behavioral research involving human subjects.
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.
Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)
The principles of professional conduct concerning the rights and duties of the physician, relations with patients and fellow practitioners, as well as actions of the physician in patient care and interpersonal relations with patient families.
The use of humans as investigational subjects.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
A situation in which an individual might benefit personally from official or professional actions. It includes a conflict between a person's private interests and official responsibilities in a position of trust. The term is not restricted to government officials. The concept refers both to actual conflict of interest and the appearance or perception of conflict.
Vaccines or candidate vaccines designed to prevent or treat cancer. Vaccines are produced using the patient's own whole tumor cells as the source of antigens, or using tumor-specific antigens, often recombinantly produced.
Component of the NATIONAL INSTITUTES OF HEALTH. It supports a comprehensive research portfolio that focuses on the biological, social, behavioral and neuroscientific bases of drug abuse on the body and brain as well as its causes, prevention, and treatment. NIDA, NIAAA, and NIMH were created as coequal institutes within the Alcohol, Drug Abuse and Mental Health Administration in 1974. It was established within the NATIONAL INSTITUTES OF HEALTH in 1992.
Agents that prevent clotting.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
The application of modern theories of learning and conditioning in the treatment of behavior disorders.
The moral obligations governing the conduct of research. Used for discussions of research ethics as a general topic.
The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
The quality or state of relating to or affecting two or more nations. (After Merriam-Webster Collegiate Dictionary, 10th ed)
The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Conduct and synthesis of systematic research comparing interventions and strategies to prevent, diagnose, treat, and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances. ( accessed 6/12/2009)
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Education that increases the awareness and favorably influences the attitudes and knowledge relating to the improvement of health on a personal or community basis.
A course of study offered by an educational institution.
A form of therapy that employs a coordinated and interdisciplinary approach for easing the suffering and improving the quality of life of those experiencing pain.
Labels pasted in books to mark their ownership and sometimes to indicate their location in a library. Private bookplates are often ornate or artistic: simpler and smaller ones bearing merely the owner's name are called "book labels." They are usually pasted on the front endpaper of books. (From Harrod, The Librarians' Glossary and Reference Book, 4th rev ed & Random House Unabridged Dictionary, 2d ed)
Published pieces of paper or other material, usually printed on one side and intended to be read unfolded and usually intended to be posted, publicly distributed, or sold. (From Genre Terms: A Thesaurus for Use in Rare Book and Special Collections Cataloguing, 2d ed)
Physical activity which is usually regular and done with the intention of improving or maintaining PHYSICAL FITNESS or HEALTH. Contrast with PHYSICAL EXERTION which is concerned largely with the physiologic and metabolic response to energy expenditure.
Reduction of high-risk choices and adoption of low-risk quantity and frequency alternatives.
Discontinuation of the habit of smoking, the inhaling and exhaling of tobacco smoke.
Groups that serve as a standard for comparison in experimental studies. They are similar in relevant characteristics to the experimental group but do not receive the experimental intervention.
Encouraging consumer behaviors most likely to optimize health potentials (physical and psychosocial) through health information, preventive programs, and access to medical care.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
Substances that reduce or suppress INFLAMMATION.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Tumors or cancer of the PROSTATE.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
The smallest continent and an independent country, comprising six states and two territories. Its capital is Canberra.
The actual costs of providing services related to the delivery of health care, including the costs of procedures, therapies, and medications. It is differentiated from HEALTH EXPENDITURES, which refers to the amount of money paid for the services, and from fees, which refers to the amount charged, regardless of cost.
Expectation of real uncertainty on the part of the investigator regarding the comparative therapeutic merits of each arm in a trial.
Therapeutic modalities frequently used in PHYSICAL THERAPY SPECIALTY by PHYSICAL THERAPISTS or physiotherapists to promote, maintain, or restore the physical and physiological well-being of an individual.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
Therapeutic approach tailoring therapy for genetically defined subgroups of patients.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
The process of finding chemicals for potential therapeutic use.
Country located in EUROPE. It is bordered by the NORTH SEA, BELGIUM, and GERMANY. Constituent areas are Aruba, Curacao, Sint Maarten, formerly included in the NETHERLANDS ANTILLES.
Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.
Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.

Meta-analysis of the reversible inhibitors of monoamine oxidase type A moclobemide and brofaromine for the treatment of depression. (1/433)

The reversible inhibitors of monoamine oxidase type A (RIMAs) are a newer group of antidepressants that have had much less impact on clinical psychopharmacology than another contemporary class of medications, the selective serotonin reuptake-inhibitors (SSRIs). The RIMAs agents are distinguished from the older monoamine oxidase inhibitors (MAOIs) by their selectivity and reversibility. As a result, dietary restrictions are not required during RIMA therapy, and hypertensive crises are quite rare. In this article, we describe a series of meta-analyses of studies of the two most widely researched RIMAs, moclobemide (MOC; Aurorex) and brofaromine (BRO). Our findings confirm that both BRO and MOC are as effective as the tricyclic antidepressants, and they are better tolerated. However, BRO is not being studied at present for reasons unrelated to efficacy or side effects. MOC, which is available throughout much of the world (but not the United States), is significantly more effective than placebo and, at the least, comparable to the SSRIs in both efficacy and tolerability. For MOC, higher dosages may enhance efficacy for more severe depressions. We also found evidence that supports clinical impressions that MOC is somewhat less effective, albeit better tolerated, than older MAOIs, such as phenelzine or tranylcypromine. Little evidence has yet emerged to suggest that the RIMAs share older MAOIs' utility for treatment of depressions characterized by prominent reverse neurovegetative features. Based on available evidence, the RIMAs appear to have a limited, but useful, role in the differential therapeutics of the depressive disorders.  (+info)

The evolution of antibiotic therapy for neutropenic patients. (2/433)

Considerable progress has been made in the treatment of infections in neutropenic patients during the past three decades. A major contribution to this progress has been the discovery of effective new therapies and their prompt administration. Unfortunately, successful therapy of each important pathogen has resulted in the emergence of new pathogens, usually with unique patterns of antibiotic susceptibility. Unfortunately, antibiotic resistance has become an increasing threat in recent years, raising the possibility of infections that will be difficult to eradicate. Fortunately, there are new classes of antimicrobials that hold promise for therapeutic success in the future.  (+info)

Systematic review of day hospital care for elderly people. The Day Hospital Group. (3/433)

OBJECTIVE: To examine the effectiveness of day hospital attendance in prolonging independent living for elderly people. DESIGN: Systematic review of 12 controlled clinical trials (available by January 1997) comparing day hospital care with comprehensive care (five trials), domiciliary care (four trials), or no comprehensive care (three trials). SUBJECTS: 2867 elderly people. MAIN OUTCOME MEASURES: Death, institutionalisation, disability, global "poor outcome," and use of resources. RESULTS: Overall, there was no significant difference between day hospitals and alternative services for death, disability, or use of resources. However, compared with subjects receiving no comprehensive care, patients attending day hospitals had a lower odds of death or "poor" outcome (0.72, 95% confidence interval 0.53 to 0.99; P<0.05) and functional deterioration (0.61, 0.38 to 0.97; P<0.05). The day hospital group showed trends towards reductions in hospital bed use and placement in institutional care. Eight trials reported treatment costs, six of which reported that day hospital attendance was more expensive than other care, although only two analyses took into account cost of long term care. CONCLUSIONS: Day hospital care seems to be an effective service for elderly people who need rehabilitation but may have no clear advantage over other comprehensive care. Methodological problems limit these conclusions, and further randomised trials are justifiable.  (+info)

Low-molecular-weight heparin in preventing and treating DVT. (4/433)

Low-molecular-weight heparin is a relatively recent addition to the list of therapies for prophylaxis and treatment of deep venous thrombosis (DVT). As a prophylactic, low-molecular-weight heparin is as effective as standard heparin or warfarin and does not require monitoring of the activated partial thromboplastin time or the International Normalized Ratio. Traditionally, treatment for DVT required patients to be hospitalized for administration of intravenous heparin. With subcutaneous injections of low-molecular-weight heparin, treatment of DVT can be initiated or completed in the outpatient setting with no increased risk of recurrent thromboembolism or bleeding complications. Low-molecular-weight heparin is an attractive option for use in patients with a first episode of DVT, no risk factors for bleeding and the ability to administer injections with or without the help of a visiting nurse or family member.  (+info)

Bipolar disorder in old age. (5/433)

OBJECTIVE: To review the classification, clinical characteristics, and epidemiology of bipolar disorders in old age with a special focus on neurologic comorbidity, high mortality, and management. QUALITY OF EVIDENCE: Most available data is gleaned from retrospective chart reviews and cohort studies. Treatment recommendations are based on evidence from younger populations and a few anecdotal case reports and series involving elderly people. MAIN MESSAGE: While relatively rare in the community setting, mania in old age frequently leads to hospitalization. It is associated with late-onset neurologic disorders (especially cerebrovascular disease) involving the right hemisphere and orbitofrontal cortex. Prognosis is relatively poor; morbidity and mortality rates are high. Management of bipolarity includes cautious use of mood stabilizers, especially lithium and divalproex. CONCLUSIONS: Mania in old age should trigger a careful assessment of underlying neurologic disease, especially cerebrovascular disease. Close clinical follow up is essential.  (+info)

New treatments for allergic rhinitis. (6/433)

OBJECTIVE: To review new treatments for allergic rhinitis. QUALITY OF EVIDENCE: Most studies supporting the principles in this paper are double-blind, placebo-controlled trials. Good evidence supports use of antihistamines, nasal steroid sprays, and immunotherapy. Fewer trials have been done on the new antileukotrienes. MAIN MESSAGE: Allergic rhinitis causes significant morbidity, which can be successfully treated. Newer antihistamines, developed to replace terfenadine and astemizole which have potential side effects, include loratadine, cetirizine, and the newest, fexofenadine. Intranasal steroid sprays are also effective, particularly for people with nasal stuffiness. One study showed some growth retardation in children using beclomethasone over a prolonged period (1 year). The newer steroid sprays, such as fluticasone, budesonide, and mometasone furoate aqueous, however, have not been studied in the same way and are usually recommended for shorter periods. The newest group of medications showing real promise are the antileukotrienes, including zafirlukast and montelukast. Taken orally, these medications avoid the discomfort of nasal sprays and seem to have few side effects. Immunotherapy offers a new option: a short-course, preseasonal series of six to 11 injections that reduces the burden on patients for year-round therapy. Combinations of these therapies are also possible. CONCLUSIONS: With new medications and immunotherapy options, family physicians can offer effective treatment to patients with allergic rhinitis.  (+info)

Chaos and the transition to ventricular fibrillation: a new approach to antiarrhythmic drug evaluation. (7/433)

Sudden cardiac death resulting from ventricular fibrillation can be separated into 2 components: initiation of tachycardia and degeneration of tachycardia to fibrillation. Clinical drug studies such as CAST and SWORD demonstrated that focusing exclusively on the first component is inadequate as a therapeutic modality. The hope for developing effective pharmacological therapy rests on a comprehensive understanding of the second component, the transition from tachycardia to fibrillation. We summarize evidence that the transition from tachycardia to fibrillation is a transition to spatiotemporal chaos, with similarities to the quasiperiodic transition to chaos seen in fluid turbulence. In this scenario, chaos results from the interaction of multiple causally independent oscillatory motions. Simulations in 2-dimensional cardiac tissue suggest that the destabilizing oscillatory motions during spiral-wave reentry arise from restitution properties of action potential duration and conduction velocity. The process of spiral-wave breakup in simulated cardiac tissue predicts remarkably well the sequence by which tachycardia degenerates to fibrillation in real cardiac tissue. Modifying action potential duration and conduction velocity restitution characteristics can prevent spiral-wave breakup in simulated cardiac tissue, suggesting that drugs with similar effects in real cardiac tissue may have antifibrillatory efficacy (the Restitution Hypothesis). If valid for the real heart, the Restitution Hypothesis will support a new paradigm for antiarrhythmic drug classification, incorporating an antifibrillatory profile based on effects on cardiac restitution and the traditional antitachycardia profile (classes 1 through 4).  (+info)

Recurrent cystitis in nonpregnant women. (8/433)

Consistent evidence from RCTs shows that antibiotic prophylaxis (either continuous or postcoital), using trimethoprim TMP-SMZ, nitrofurantoin, or a quinolone, reduces infection rates in women with high rates of recurrent cystitis (at least two per year). Limited evidence suggests that intermittent patient-administered treatment (taken at the onset of symptoms) is an effective alternative management strategy to continuous antibiotic prophylaxis in women with high rates of infection (at least two per year). Limited evidence suggests that long-term prophylaxis is likely to benefit women with a baseline rate of more than two infections per year over many years. However, long-term treatment has not yet been evaluated in RCTs. In women who experience recurrent, uncomplicated cystitis, there is no evidence to support routine investigation of the urinary tract with excretory urography, ultrasonography, cystoscopy, or voiding cystourethrography. No specific subgroups of women who would clearly benefit from investigation have yet been adequately defined.  (+info)

Come for STORYTIME fun for 2 - 5 year olds. Our Storytime features stories & more. We have Storytime every Monday, starting at 10:30 a.m., unless otherwise noted. We sometimes have guest authors and presenters.. ...
Learn more about what CCTS can do for your research efforts from key CCTS program managers: Marietta Barton-Baxter, CCRC, Administrative Director of the Clinical Services Core and Program Specialist for Regulatory Support and Research Ethics
Dyax Corp. (NASDAQ: DYAX) and CMIC Co., Ltd, (CMIC) announced today an agreement to develop and commercialize subcutaneous DX-88 (ecallantide) for the
Comments below, prefixed by [Diego]. Diego , p.75: , , 7.1.1 Stored Core Components , , [S1] , - Unique Identifier , , [JMC] Defer to existing RIM spec: UUID assigned to RegistryObject. No , updates necessary for CC. , , - Version , , [JMC] Defer to existing RIM spec: MajorVersion and MinorVersion , RegistryEntry attributes. No updates necessary for CC. , , - Dictionary Entry Name (already covered: , - Definition (already covered: RegistryObject.description) , , - Usage Rule: See p.65 Section 6.2.4 , , [JMC] Out of our scope, as it references Section 6 (we are verifying , Section 7). Sidenote: Section 6 will most likely be covered by OASIS , CAM. , , p.76: , , [S2] , Stored Core Components shall always be defined as one of the 4 , recognized types: Basic Core Component (p.77 Section 7.1.6), , Association , Core Component (p.77 Section 7.1.7), Aggregate Core Component (p.76 , Section 7.1.2), or Core Component Type (p.77 Section 7.1.8) , , [JMC] Use ObjectType ...
We propose to use HIV-1 self-testing to reduce the frequency of clinic visits for persons taking PrEP, and we will evaluate the effectiveness and safety of our approach using a randomized, non-inferiority trial among women and men initiating PrEP in Kenya.. ...
This study suggests that COBRA-light therapy may be a feasible alternative to COBRA in the first 6 months of treatment. As the CI of the observed difference in ΔDAS44 includes the predefined clinically relevant threshold of 0.5, we are unable to claim non-inferiority fully. However, when analyses were performed with a two-sided 90% CI, or when DAS44 was calculated with CRP, the CI of the ITT and per-protocol analyses are within the predefined threshold of 0.5. The results were consistent across the secondary outcomes, with some trends even favouring COBRA-light (eg, ACR/EULAR remission and ACR50 and ACR70 responses), and only the ESR proved significantly lower in the COBRA arm. In fact, this difference in ESR is the main driver for the observed difference in ΔDAS44 between the groups. In addition, no differences were seen in the safety profile. In other words, COBRA-light therapy seems to be equally effective and safe but has the advantage that it incorporates a lower initial dose of ...
Im not sure its quite as bad as you make out and certainly not in the same league as homeopathy and magnetic bracelets. Your critique of the sub-group analysis implies either carelessness or a misunderstanding of statistics. Splitting the groups for analysis means fewer participants in each arm, thus the error bars for each group increase. This is why larger trials are preferable as they reduce the statistical error. The authors make no claims pertaining to the sub-groups. There is a plausible mechanism of action. The cited paper from Liebmann et al indicates NO production from blue light at 453nm, and NO is implicated in CNS signalling and pain mediation (see e.g. Meller ST, Gebhart GF. 1993. Nitric oxide (NO) and nociceptive processing in the spinal cord. Pain 52:127-36).. The thresholds raise an interesting question. While the difference between the control/placebo group and treatment group is 9mm, but the control group improvement is ,9mm. Therefore the improvement of the treatment group ...
KALBITOR (Ecallantide) drug information & product resources from MPR including dosage information, educational materials, & patient assistance.
file. Doug, one more game this season. The offense…was it what you expected? Are you disappointed? Can you talk about the progress of the offense and what your expectations were at the beginning of the season and now heading into Ohio State, where you guys are 13th of 14 in total offense?. Obviously our expectations are a lot higher than where were at right now. As Ive touched on throughout the season you talk about individual improvement [and it] hasnt necessarily led to total group improvement. Do feel good about the things that were progressing in. You talk about the ability to run the football. I believe in the last three were averaging like 207 yards a game or something like that rushing in the last three games. Really feel like that lines starting to gel together. You talk about protection and the fact that we gave up two this week; one was an assignment error and we gave up one true sack on a zero blitz. We got caught by surprise. Weve got to have a better plan down there as far ...
View the complete listing of upcoming CCTS, campus and Chicago area events. To submit an event to the calendar, email [email protected] ...
Explore Latest Updates on Cell Therapy Conference and Gene Therapy Conferences happening in Asia, Australia, Europe, USA, Canada and Japan in 2018
Does any body have any insight or experience running a non-inferiority test based on multiple linear or logistic regression. So perhaps mean and risk...
A large, quirky database of scientific sources about musculoskeletal pain, injury & treatment, constantly updated & annotated 1997-2018.
The primary goal of this non-inferiority trial was to determine if an intermittent treatment regimen was not inferior to a continuous regimen, in first-line
All studies are led by a protocol, which establishes what the trial will study, who is a good candidate for the study, what treatments (if any) will be used, and how results will be measured.. In a randomized, controlled clinical trial, children are separated into groups. The experimental group(s) will receive the treatment that is to be tested, while the control group(s) will get the usual treatment (usually what a child is already taking) or placebo (a fake treatment or sugar pill that contains no medicine at all).. In clinical trials on children, placebo is used only if the lack of treatment is short (perhaps a few days) and poses minimal risks, or if the therapy being tested is used to only treat uncomfortable symptoms (like watery eyes) and not a severe illness.. In these types of trials, patients are blinded, which means they dont know who is getting the treatment and who is getting the placebo until the trial is over. That way, their perceived response to the drug or placebo cant be ...
Are there any clinical trials on going? There are a couple of trials recruiting now in the US and in Europe. Click here to read more.
It may have been an unusual request at that point, but when a local grandmother recently stopped by Framinghams Board of Health for an H1N1 flu shot, she received one on the spot.
Natural Cycle Ivf in Gorakhpur near me. View fee, user feedback & book appointment with Natural Cycle Ivf doctors on DoctoriDuniya
Best Doctors for natural cycle ivf in Agra - find doctors near you. Book Doctors Appointment Online, View Cost for Lab Tests treatment in Agra | Elawoman
Heres an all-too-real example from recent personal experience. A drug manufacturer wants to understand physicians rationales for performing a certain procedure. It seems - but there is little hard data - that a lot of physicians do not strictly follow guidelines on when to perform the procedure. So we devise a study: whenever the procedure is performed, we ask the physician to complete a quick form categorizing why they made their decision. We also ask him or her to transcribe a few pieces of data from the patient chart ...
Clear Choice Technical Services in Overland Park blog section You can read different topics about the copier type articles by CCTS in Overland Park.
It is difficult to ensure that treatment comparison groups are sufficiently similar in terms of prognostic variables in non-randomized studies, particularly prognostic variables that remain undiscovered ...
When running meta-regression on continuous moderator variables, some of the variable run nicely, while others end with the error message: Cannot run meta-regr…
Less than a decade after being hatched out of a Texas university, Houston-based Bellicum Pharmaceuticals is in the midst of clinical trials on two
Why did we develop TIDieR-Placebo? The TIDieR reporting guideline helps authors fully report their interventions, so that they can be used by others. However, TIDieR only explicitly covers active interventions, not placebo controls. The developers of the new TIDieR-Placebo extension explain why it is needed Read More. ...
Why did we develop TIDieR-Placebo? The TIDieR reporting guideline helps authors fully report their interventions, so that they can be used by others. However, TIDieR only explicitly covers active interventions, not placebo controls. The developers of the new TIDieR-Placebo extension explain why it is needed Read More. ...
Our results suggest that in ventilated pediatric patients with ALI: both SI and SRS effectively raise PaO2 and FRC; SI may be associated with temporary desaturation in children; SRS is associated with an increase in PaCO2 during the maneuver; and both SI and SRS are hemodynamically well tolerated.. Several studies have noted that both SI and SRS are effective in raising PaO2 in adults and children with ARDS.7,11,13,23 When an SRS was applied following an SI, in non-randomized fashion, Borges et al11 noted that PaO2 rose further following SRS. When assessed using computed tomography, Borges et al also noted regions of lung collapse that had not opened following SI became aerated following SRS. This is consistent with the increase in FRC we demonstrated following SRS, compared to following SI. However, in both the Borges et al study and our study, the non-randomized, sequential application of SRS after an SI precludes any conclusions regarding the efficacy of one maneuver over the other; it is ...
Conditional cash transfers (CCTs) are an increasingly significant component of national social protection systems. CCTs have been associated with positive effects on poverty reduction, increased school attendance and use of health services, as well as reductions in child labour. Some claim that CCTs contribute to the empowerment of women and girls. Whether or not the conditionalities attached to these transfers play a role in producing these positive outcomes remains an open and much-debated question. Against this backdrop, the brief reviews a decade of feminist research on CCTs that has raised serious questions about the assumptions that underpin the use of conditionalities and their impact on poor womens lives. The brief highlights particular concerns about the detrimental effects that conditionalities may have in contexts where quality public services are lacking and where multiple and intersecting forms of discrimination mean that well-intended programme requirements easily slip into ...
Pilot studies are key sources of innovation at the University of Massachusetts Center for Clinical and Translational Science (UMCCTS). Over the past few years, we have developed a pilot portfolio that leverages CTSA funding with institutional and industry partnership to catalyze innovation and collaboration across the translational spectrum. The primary aim of the UMCCTS pilot grant programs is to support innovative projects most likely to yield a new product for approach that addresses a significant health issue.
Hello, It has taken me some time to find full text documents regarding clinical trials on diet and omega3/omega6 suppliments mentioned here and in the book. Most of google search returnes only abstracts and not full text. Im not sure ...
The good folks down at eyeforpharma have asked me to write a few blog posts in the run-up to their Patient Centered Clinical Trials conference in Boston this September. In my second article -Buzzword Innovation: The Patient Centricity Fad and the Token Patient - I went over some concerns I have regarding the sudden burst of enthusiasm for patient centricity in the clinical trial world ...
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
This is a Phase I, multi-centre, non-randomized, uncontrolled, open-label, dose escalating study of BI 836880 administered intravenously once a week. The
Clinical Trials and YOU What are clinical trials? Controlled studies to determine how a particular anti-cancer strategy ( i.e. treatment ) affects the people who receive it Involve rigorous scientific
Video created by 约翰霍普金斯大学 for the course Introduction to the Biology of Cancer. In this final week, well examine the variety of treatment options available to doctors and patients as well as the features of clinical trials and how they are ...
If youve decided that you would like to learn more about participating in clinical trials, start by talking to your doctor. He or she probably knows ...
Hi there! Im new here and I was wondering if there are any upcoming clinical trials. Id like to get on the list for those! Thanks, Jennifer
பெல்ஸ் பால்ஸி அல்லது பெல்ஸ் பால்ஸி அல்லது (முதல்நிலை) காரணமில்லாத முகவாதம் என்பது முக தசைகளின் இயக்கங்களை கட்டுபடுத்தும் ஏழாவது நரம்பை பொதுவாக பாதிக்கும் கோளாறு. இது முகத்தில் உள்ள ஒரு பக்க தசைகளை வலுவிழக்க அல்லது செயலிழக்க செய்யும். தசைகள் வலுவிழப்பதால் முகம் உருகுலைந்து போவதுடன் வழக்கமான செயல்பாடுகளாகியகண் இமைகள் திறந்து மூடுதல்மற்றும் உண்ணுதலில் சிரமம் ...
இடைவிடு கஞ்சத்துவம் என்பது நடக்கும் போது உண்டாகும் ஒரு தசைப்பிடிப்பு கால் வலி ஆகும், இது ஓய்வின் போது இருக்காது. இது பெருந்தமனி தடிப்பு (தமனிகள் வழியாக செல்லும் இரத்த ஓட்டத்தை கட்டுப்படுத்தும் கொழுப்பு வைப்புகள்) காரணமாக கால் தசைகளுக்கு போதுமானஅளவு இரத்த ஓட்டம் இல்லாததால் ஏற்படுகிறது. லேசானது முதல் மிதமான கஞ்சத்துவம் உள்ள மக்கள் நடைபயிற்சியினைத் தொடரவும் , ...
FDA Anti-Infective Drugs Advisory Committee. Design Issues in ABS Trials: Surrogates Endpoints & Non-Inferiority Trials October 29, 2003 Thomas R. Fleming, Ph.D. Professor and Chair of Biostatistics University of Washington. Design Issues in ABS Trials. Criteria for Study Endpoints Slideshow 6407475 by kamal-huff
All-natural cycle IVF is in vitro fertilization, yet just without the use of large amounts of medicines to stimulate the ovary to make multiples eggs. Females do obtain everyday shots towards the end of the cycle to prevent very early ovulation, and also throughout that time, small quantities of gonadotropin drug are necessary to sustain the growth of the egg.
This page contains the abstract: A Dose of Our Own Medicine: Alternative Medicine, Conventional Medicine, and the Standards of Science
GlobalDatas clinical trial report, Hemostasis Global Clinical Trials Review, H1, 2012 provides data on the Hemostasis clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Hemostasis. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Hemostasis. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts.
GlobalDatas clinical trial report, Pulmonary Edema Global Clinical Trials Review, H2, 2013 provides data on the Pulmonary Edema clinical trial scenario. This report provides elemental information and data relating to the clinical trials on Pulmonary Edema. It includes an overview of the trial numbers and their recruitment status as per the site of trial conduction across the globe. The databook offers a preliminary coverage of disease clinical trials by their phase, trial status, prominence of the sponsors and also provides briefing pertaining to the number of trials for the key drugs for treating Pulmonary Edema. This report is built using data and information sourced from proprietary databases, primary and secondary research and in-house analysis by GlobalDatas team of industry experts.
New Data Presented Build on Positive Phase 2b Findings, Demonstrate Correlation Between Improved Cognition and Plasma Levels of EVP-6124
TY - JOUR. T1 - Strategies to improve retention in randomised trials. AU - Gillies, Katie. AU - Kearney, Anna AU - Keenan, Ciara. AU - Treweek, Shaun. AU - Hudson, Jemma. AU - Brueton, Valerie C.. AU - Conway, Thomas. AU - Hunter, Andrew AU - Murphy, Louise AU - Carr, Peter J.. AU - Rait, Greta. AU - Manson, Paul. AU - Aceves-Martins, Magaly N1 - [Methodology]. PY - 2021/3/6. Y1 - 2021/3/6. N2 - Background:Poor retention of participants in randomised trials can lead to missing outcome data which can introduce bias and reduce study power, affecting the generalisability, validity and reliability of results. Many strategies are used to improve retention but few have been formally evaluated. Objectives:To quantify the effect of strategies to improve retention of participants in randomised trials and to investigate if the effect varied by trial setting. Search methods: We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Scopus, PsycINFO, CINAHL, Web of Science Core ...
New life-saving treatments for Autism in clinical trial on A Double-Blind, Randomized, Placebo Controlled Study of CM_AT for the Treatment of Autism in Children 3-8 Years Old. (The Blüm Study)
Clinical trials provide information about the safety and effectiveness of new approaches to see if they should become widely available. Most of the standard cancer treatments used today were first shown to be effective through clinical trials.. There are many reasons why someone may choose to take part in a clinical trial.. ...
CLINICAL TRIALS AVAILABLE IN THE PHOENIX AREA Myelodysplastic Syndrome: TetraLogic 0087 A Phase 1b/2a, Open-label, Non-randomized Study of Birinapant
Did you know you can Make Money Doing Clinical Trials? There are quite a few clinical trials available right now. You can possibly get free medicine and get PAID for your thoughts and opinions on the product. The payout on these can be really high - most are several hundred…
Clinical trials test interventions that may help treat or prevent disease and are used to determine whether new therapies are safe and effective
This model addresses the planning of global clinical trials and the forecasting of long-range expenses to accurately allocate project resources. It
The earliest publication of a controlled clinical trial appears to be from 1945.[27] Researchers continued to work on this ... started publishing research on the topic and also published a book "Vitamin C and the Common Cold" in 1970.[28] A revised and ... The disease was shown to be prevented by citrus fruit in an early controlled trial by a Royal Navy surgeon, James Lind, in 1747 ... A meta-analysis of 44 clinical trials has shown a significant positive effect of vitamin C on endothelial function when taken ...
... but placebo-controlled clinical trials could not always replicate these findings. As of 2017, vitamin E continues to be a topic ... but no confirming evidence from placebo-controlled clinical trials. A meta-analysis published in 2005 concluded that diets ... identified only one vitamin E clinical trial. That trial compared 500 IU/day of alpha-tocopherol to placebo for four years and ... A large clinical trial known as AREDS compared beta-carotene (15 mg), vitamin C (500 mg) and alpha-tocopherol (400 IU) to ...
Discussion topics when setting up an experimental designEdit. An experimental design or randomized clinical trial requires ... Statistical controlEdit. It is best that a process be in reasonable statistical control prior to conducting designed ... James Lind carried out a systematic clinical trial to compare remedies for scurvy.[1] This systematic clinical trial ... Systematic clinical trialsEdit. This section possibly contains original research. Please improve it by verifying the claims ...
Most severe clinical events do not occur at plaques that produce high-grade stenosis. From clinical trials, only 14% of heart ... Research on genetic expression and control mechanisms is progressing. Topics include: PPAR, known to be important in blood ... The trial was published in JAMA in early 2006.[citation needed] Ongoing work starting in the 1990s may lead to human clinical ... However, clinical trials have shown that only about 14% of clinically debilitating events occur at sites with more than 75% ...
... placebo-controlled trials examining the clinical efficacy of vitamin D in multiple sclerosis". Neuroepidemiology (Systematic ... Emerging and Evolving Topics in Multiple Sclerosis Pathogenesis and Treatments. Current Topics in Behavioral Neurosciences. 26 ... not the randomized clinical trials considered to be more definitive. Until such trials are conducted, the implications of the ... Depression -- Clinical trials of vitamin D supplementation for depressive symptoms have generally been of low quality and show ...
Role of the clinical data manager in a clinical trial[edit]. Job profile acceptable in CDM: clinical researcher, clinical ... Quality control[edit]. Quality Control is applied at various stages in the Clinical data management process and is normally ... Key topics to cover include the SOPs to be followed, the clinical data management system (CDMS) to be used, description of data ... The clinical data manager plays a key role in the setup and conduct of a clinical trial. The data collected during a clinical ...
... clinical trials, randomized controlled trials, efficacy tests, and clinical pharmacology. The work is considered one of the ... Importance: Topic creator, Breakthrough, Impact The Canon of Medicine Author: Avicenna (Ibn Sina) Publication data: The Canon ... A prospective clinical trial which ran from 1951 to 2001, and in 1956 provided convincing statistical evidence that tobacco ... 4 (2). Eldredge Jonathan D (2003). "The Randomised Controlled Trial design: unrecognized opportunities for health sciences ...
In 2007 the organization established the Clinical Trials Registry - India, which is India's national registry for clinical ... fertility control, maternal and child health, control of nutritional disorders, developing alternative strategies for health ... trials. ICMR's 26 national institutes address themselves to research on specific health topics like tuberculosis, leprosy, ... "Clinical Trials Registry - India: An overview and new developments". Indian Journal of Pharmacology. 50 (4): 208. doi:10.4103/ ...
... design Central composite design Clinical trial Clinical study design Computer experiment Control variable Controlling for a ... The study of the design of experiments is an important topic in metascience. A theory of statistical inference was developed by ... An experimental design or randomized clinical trial requires careful consideration of several factors before actually doing the ... To control for nuisance variables, researchers institute control checks as additional measures. Investigators should ensure ...
... placebo-controlled phase 2 clinical trial". The Lancet. 381 (9871): 1037-45. doi:10.1016/S0140-6736(12)61764-4. PMID 23352749. ... "Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology. 325: 361-382. doi:10.1007/978-3- ... "Inferring Reasons for the Failure of Staphylococcus aureus Vaccines in Clinical Trials". Frontiers in Cellular and Infection ... Adenovirus Vaccine Efficacy Trial Consortium (2013). "A phase 3, randomized, double-blind, placebo-controlled study of the ...
From the information technology perspective for clinical trials, it has been guided by another U.S. Food and Drug ... In a Good Manufacturing Practice regulated industry, the topic is frequently encountered by its users. Various industrial ... "Guidance for Industry: Computerized Systems Used in Clinical Trials" (PDF). U.S. Food and Drug Administration. April 1999. ... Taylor, J. (2008). Project Scheduling and Cost Control: Planning, Monitoring and Controlling the Baseline. J. Ross Publishing. ...
No evidence based on well-controlled clinical trials is available that supports a cause-and-effect relationship between ... "Safety and Health Topics , Multiple Chemical Sensitivities". Retrieved 2014-06-08.. ... Some blinded clinical trials have shown that the study subjects reacted as often and as strongly to placebos as they did to ... As a consequence, clinical ecology emerged as a non-recognized medical specialty.[40] In 1984, the Society for Clinical Ecology ...
Systematic reviews and meta-analyses of randomized controlled trials can provide strong evidence of the clinical efficacy of ... which can be useful when outlining a topic. Systematic reviews use sophisticated methodology to address a particular clinical ... For example, results of an early-stage clinical trial would not be appropriate in the Treatment section on a disease because ... The best evidence for treatment efficacy is mainly from meta-analyses of randomized controlled trials (RCTs).[12] Systematic ...
... she performed a clinical trial across a mixed sampling of her clients. Finding the trial was successful, she introduced the ... control clinic in the Netherlands and the first clinic in the world devoted solely to disseminating information on the topic. ... Her pioneering birth control clinic preceded both Margaret Sanger's and Marie Stopes's clinics in the United States and England ... Both women were deeply involved in the fight for women's suffrage as well as other social issues, including birth control. She ...
... unpublished studies that are reviewed for methodological rigor with special attention to the results of clinical trials. A ... Drafts are also provided to the Food and Drug Administration and Centers for Disease Control and Prevention and to all first ... of the advisory board and 10-20 other investigators with relevant clinical or experimental experience with the article's topic ...
The ability of activated ex vivo NK cells has been a topic of interest for the treatment of tumors. After early clinical trials ... As NK cells are not themselves specific to certain pathways of immune control, they are utilized a majority of the time in ADCC ... The typical ADCC involves activation of NK cells by antibodies in a multi-tiered progression of immune control. A NK cell ... biological evidence and clinical perspectives". Annals of Translational Medicine. 7 (5): 105. doi:10.21037/atm.2019.01.42. ISSN ...
... a systematic review and meta-analysis of randomised controlled trials". European Journal of Clinical Investigation. 44 (4): 429 ... "Electrotherapy - an overview , ScienceDirect Topics". Retrieved 2020-11-26.. ... "BMJ Clinical Evidence. 2011. PMC 3217823. PMID 21524319.. *^ Cullum N, Petherick E (2008). "Pressure ulcers". BMJ Clinical ... a meta-analysis of randomized controlled trials". The Journal of Bone and Joint Surgery. American Volume. 90 (11): 2322-30. doi ...
Randomized controlled trial Blind trial Non-blind trial Adaptive clinical trial Nonrandomized trial (quasi-experiment) ... Some of the considerations here are shared under the more general topic of design of experiments but there can be others, in ... Clinical study design is the formulation of trials and experiments, as well as observational studies in medical, clinical and ... "Flu, Season, Diseases Affect Trials". Applied Clinical Trials Online. Archived from the original on 11 July 2011. Retrieved 26 ...
"VivaGel™ - Clinical trials Under Way". Star Pharma. Archived from the original on 7 January 2008. Retrieved 1 April 2018. ... control to fight AIDS. "Research:New vaginal ring borrows from birth control to fight AIDS". Archived from the original on 2010 ... World Health Organization (2002). "HIV/AIDS Topics: Microbicides". Geneva: World Health Organization. Retrieved August 28, 2006 ... "Microbicide Clinical Trials". AVAC. Archived from the original on 16 July 2011. Retrieved 1 April 2018. Global Campaign for ...
Safer and more effective clinical trials. Evolution[edit]. This section may stray from the topic of the article. Please help ... Former National Coordinator David Brailer indicated his support for portable personal health records which are controlled by ... "Journal of Evaluation in Clinical Practice. 18 (1): 56-62. doi:10.1111/j.1365-2753.2010.01522.x. ISSN 1365-2753. PMID 20698917. ... Personal health records, or PHRS, (see personal health record) - are essentially medical records controlled and maintained by ...
In a placebo controlled Phase II clinical trial with 351 subjects, eplivanserin reduced the sleep latency by 39 minutes (versus ... Teegarden BR, Al Shamma H, Xiong Y (2008). "5-HT(2A) inverse-agonists for the treatment of insomnia". Current Topics in ...
All the randomized clinical trials of TM for the control of blood pressure published to date have important methodological ... Evaluation of the evidence from randomized controlled trials". International Journal of Clinical Practice. 63 (7): 1068-84. doi ... a systematic review of clinical trials". Journal of Clinical Oncology. 24 (1): 136-40. doi:10.1200/JCO.2005.03.8406. PMC ... A systematic review of randomised clinical trials". International Journal of Clinical Practice (Systematic Review). 62 (6): 947 ...
... placebo-controlled clinical trials and a review of over 10 years of postauthorization data". Journal of Pain Research. 10: 2451 ... Current Topics in Medicinal Chemistry. 7 (3): 235-49. doi:10.2174/156802607779941323. PMID 17305567. Kiehl S (March 13, 2005 ... It is well known from previous clinical trials that its peak serum concentrations occur about 30 minutes after intravenous (IV ... It is approved through much of Europe for short term perioperative pain control. It was patented in 1996 and approved for ...
"Stratification in the design of a clinical trial", Controlled Clinical Trials, 1 (4): 355-361, doi:10.1016/0197-2456(81)90040-4 ... "Current research in statistical methodology for clinical trials", Biometrics -- Proceedings of Current Topics in Biostatistics ... "Jerome Cornfield and the methodology of clinical trials", Controlled Clinical Trials, 1 (4): 339-345, doi:10.1016/0197-2456(81) ... "Choosing covariates in the analysis of clinical trials", Controlled Clinical Trials, 10 (4): 161-175, doi:10.1016/0197-2456(89) ...
... and Withings products have been involved in numerous clinical trials. Connected health Quantified Self ... It has no buttons and is controlled from a phone app, compatible with both iPhone and Android. It can track the user's sleep, ... The Institute has published several research papers on various topics, ... In May 2018, Éric Carreel, Withings' founder, finalized a deal to regain control and the company became independent again, ...
... systematic review and meta-analysis of randomised controlled trials". BMJ (Clinical Research Ed.). 347 (20): f6234. doi:10.1136 ... Topics in Stroke Rehabilitation. 20 (3): 197-209. doi:10.1310/tsr2003-197. hdl:10044/1/32069. PMID 23841967.. ... the EXCITE randomized clinical trial". JAMA: The Journal of the American Medical Association. 296 (17): 2095-104. doi:10.1001/ ... a prospective controlled trial". Journal of Neuroengineering and Rehabilitation. 10: 85. doi:10.1186/1743-0003-10-85. PMC ...
"Are the clinical effects of homoeopathy placebo effects? Comparative study of placebo-controlled trials of homoeopathy and ... teaching includes such topics as doctor-patient communication, ethics, the art of medicine,[96] and engaging in complex ... clinical statisticians and pharmacologists, use clinical trials to reveal such effects, allowing physicians to offer a ... Research into alternative therapies often fails to follow proper research protocols (such as placebo-controlled trials, blind ...
... and Infection Prevention and Control Issues for Laboratory Professionals". Clinical Laboratory Medicine (Review). 37 (2): 269- ... Current Topics in Microbiology and Immunology. Ebolavirus and other filoviruses. 315. pp. 363-87. doi:10.1007/978-3-540-70962-6 ... Several trials were conducted in late 2014, and early 2015, but some were abandoned due to lack of efficacy or lack of people ... Centers for Disease Control and Prevention and World Health Organization (1998). Infection Control for Viral Haemorrhagic ...
Clinical observations[edit]. A study involving 2408 donors (18-60 years) indicated that bone pain (primarily back and hips) as ... To cryopreserve HSC, a preservative, DMSO, must be added, and the cells must be cooled very slowly in a controlled-rate freezer ... "The Only Real Cure Out There, for Now " Archived 30 May 2008 at the Wayback Machine.. CLL Topics, Inc. ... "Adverse events among 2408 unrelated donors of peripheral blood stem cells: results of a prospective trial from the National ...
Clinical laboratory sciences are the clinical diagnostic services that apply laboratory techniques to diagnosis and management ... Trial of the Nuremberg trials, Tuskegee syphilis experiment, and others.. Values such as these do not give answers as to how to ... Education and legal controls[edit]. Main articles: Medical education and Medical license ... Subspecialties include transfusion medicine, cellular pathology, clinical chemistry, hematology, clinical microbiology and ...
Grissom RJ (1994). "Statistical analysis of ordinal categorical status after therapies". Journal of Consulting and Clinical ... However it would be rare to find so extended a report in a document whose major topic was not statistical inference. ... Controlled experiments. *Design *control. *optimal. *Controlled trial. *Randomized. *Random assignment. *Replication. *Blocking ...
In clinical trials involving more than 10,000 people, the vaccine, called LYMErix, was found to confer protective immunity to ... A randomized, double-blind, placebo-controlled trial". Annals of Internal Medicine. 138 (9): 697-704. doi:10.7326/0003-4819-138 ... "CDC - Lyme Disease - NIOSH Workplace Safety and Health Topic". 3 August 2017. Archived from the original on 13 ... "European Journal of Clinical Chemistry and Clinical Biochemistry (Submitted manuscript). 32 (9): 685-9. doi:10.1515/cclm. ...
... but that reports were based on data from clinical trials without sham controls and that the specific cost-effectiveness of the ... List of topics characterized as pseudoscience. *Chiropractic education. *Chiropractic schools. *Councils on Chiropractic ... Numerous controlled clinical studies of treatments used by chiropractors have been conducted, with conflicting results.[4] ... Ernst E (December 2009). "Spinal manipulation for asthma: a systematic review of randomised clinical trials". Respir Med. 103 ( ...
42] The law encourages patient diversity in clinical trials submitted to the FDA for review. The study determined that most ... "General Controls for Medical Devices". Medical Devices. U.S. Food and Drug Administration. Retrieved 2010-10-15.. ... The US FDA also published a series of guidances for industry regarding this topic against 21 CFR 820 Subchapter H-Medical ... Fox-Rawlings S,. Gottschalk L.B., Doamekpor L., Zuckerman D.M. (2018) Diversity in Medical Device Clinical Trials: Do We Know ...
... a randomized placebo-controlled 25-week outpatient trial". Pharmacopsychiatry. 30 (1): 1-5. doi:10.1055/s-2007-979474. PMID ... Journal of Clinical Psychopharmacology. 20 (1): 84-9. doi:10.1097/00004714-200002000-00014. PMID 10653213.. ...
Further randomized controlled trials are needed to delineate these differences more clearly." The conclusions were contrary to ... "American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of ... FFC). Holtorf has published a number of endocrine reviews on complex topics in peer-reviewed journals on controversial diseases ... Clinical Practice Guidelines by the Infectious Diseases Society of America". Clinical Infectious Diseases. 43 (9): 1089-134. ...
The Medicines for Human Use (Clinical Trials) Regulations 2004. *The Medicines for Human Use (Clinical Trials) Amendment ... Restriction of use of placebo in control group where effective alternative treatment is available ... ICH Topic E 6 (R2). *Good Clinical Practice (from U.S. Food and Drug Administration) ... The National Institutes of Health requires NIH-funded clinical investigators and clinical trial staff who are involved in the ...
... a systematic review of randomized clinical trials". Br. J. Anaesth. 84 (3): 367-371. doi:10.1093/oxfordjournals.bja.a013442. ... "An Evaluation of Several Mulch Materials on Landscape Plant Growth, Weed Control, Soil Temperature and Soil Moisture : Interim ... A systematic review of clinical trials". Pain Medicine. 12 (12): 1808-18. doi:10.1111/j.1526-4637.2011.01261.x. PMID 22054010. ...
... and active training reduce the risk of contamination but that more randomized controlled trials are needed for how best to ... These include psychiatrists, psychiatry physician assistants, clinical psychologists, occupational therapists, clinical social ... *^ ... Based on recommendations from The Center for Disease Control and Prevention (CDC) for TB screening and testing the following ...
"ISIS initiates Phase 3 clinical trials for potential SMA therapy ISIS-SMNrx". The SMA Trust.. ... Stillman, B (December 1996). "Cell cycle control of DNA replication". Science. 274: 1659-64. Bibcode:1996Sci...274.1659S. doi: ... Topics. *Contributing property. *Keeper of the Register. *Historic district. *History of the National Register of Historic ... develop a new clinical cancer research unit at Northwell Health in Lake Success, NY, to support early-phase clinical studies of ...
Motor control functions[edit]. Musical performance usually involves at least three elementary motor control functions: timing, ... Chen, R; Hallett, M (1998). "Focal dystonia and repetitive motion disorders". Clinical Orthopaedics and Related Research (351 ... "Decoding auditory attention to instruments in polyphonic music using single-trial EEG classification". Journal of Neural ... these results indicate that motor timing is not controlled by a single brain region, but by a network of regions that control ...
Randomized, placebo-controlled trial of inactivated poliovirus vaccine in Cuba. N Engl J Med. 2007 Apr 12;356(15):1536-44. Free ... Basic work teams within the polyclinics supervise and evaluate the neighborhood and clinical health work of the family medicine ... A 2018 paper using a synthetic control method found that infant mortality increased in the first years of the Castro regime ... The Collaborative Group consisted of the Cuban Ministry of Public Health, Kourí Institute, U.S. Centers for Disease Control and ...
Parkes, B. Ginsberg, R. Jamal, A. Frid, Ultra-short (5mm) insulin needles: trial results and clinical recommendations. ... Strauss speaks frequently to audiences throughout Europe, Africa and the Middle East on topics related to diabetes, HIV disease ... Initial results of Central European Immunophenogyping Quality Control Program (CEQUAL). Cytometry 26:108-112. F. Hulstaert, J. ... Clinical Immunology and Immunopathology, 1994; 70:152-158. K. Strauss, I. Hannet, S. Engels, A. Shiba, D. Ward, S. Ullery, M. ...
List of vaccine topics. *#WHO-EM. *‡Withdrawn from market. *Clinical trials: *†Phase III ... The earliest recorded artificial induction of immunity in humans was by variolation or inoculation, which is the controlled ... It is hoped that further understanding of the molecular basis of immunity will translate to improved clinical practice in the ... Centers for Disease Control and Prevention (CDC).. ...
... clinical endpoint - clinical latency - clinical practice guidelines - clinical trial - - cloning - CMS - CMV ... phase II trials - phase III trials - phase IV trials - photosensitivity - PHS - pituitary gland - placebo - placebo controlled ... This is a list of AIDS-related topics, many of which were originally taken from the public domain U.S. Department of Health ... Community Programs for Clinical Research on AIDS (CPCRA) - community-based clinical trial (CBCT) - community-based organization ...
... none of these strategies have proven to be efficacious in TBI clinical trials [13-15]. The failure of clinical therapy trials ... 3) The biomarker must have low background or basal biofluid levels in general noninjured healthy control population. (4) The ... Scholia has a topic profile for Biomarker.. Retrieved from " ... Status and relevance for clinical trials". Mov. Disord. (Review). 33 (4): 528-36. doi:10.1002/mds.27355. PMID 29624752.. ...
Garçonne (aka Frauenliebe (Woman Love)) was aimed at lesbians and male transvestites.[82] These publications were controlled by ... Foster suggests that women would have encountered suspicion about their own lives had they used same-sex love as a topic, and ... Two months later, they were found guilty in a jury trial. The producers were fined $200 and the cast received suspended ... Journal of Consulting and Clinical Psychology, 71 (1), pp. 53-61. ...
A systematic review of randomised clinical trials". BMJ Open. 4 (11): e006140. doi:10.1136/bmjopen-2014-006140. PMC 4225238. ... Kuhnholz, Susanne (1997). "The Control of Water Collection in Honey Bee Colonies". Behavioral Ecology and Sociobiology. 41: 407 ... Bee venom is under laboratory and clinical research for its potential properties and uses in reducing risks for adverse events ... there are no approved clinical uses for these products which carry various warnings for potential allergic reactions.[82] ...
Controlled experiments. *Scientific control. *Randomized experiment. *Randomized controlled trial. *Random assignment. * ... List of statistical topics. *Kirkwood approximation. *Moment-generating function. *Quasiprobability distribution. *Riemann- ... Related to Bernoulli trials (yes/no events, with a given probability)[edit]. *Basic distributions: *Bernoulli distribution, for ... Nevertheless, in quality control one might demand that the probability of a "500 g" package containing between 490 g and 510 g ...
Chemotherapy has been shown in a randomized controlled trial to improve quality of life and extend survival in people with ... clinical manifestation and control. Advances in Parasitology. 72. pp. 305-50. doi:10.1016/S0065-308X(10)72011-X. ISBN ... Scholia has a topic profile for Cholangiocarcinoma.. *American Cancer Society Detailed Guide to Bile Duct Cancer. ... a phase II trial". Journal of Clinical Oncology. 23 (10): 2332-8. doi:10.1200/JCO.2005.51.008. PMID 15800324.. ...
... on the control over clinical trials exerted by sponsors, particularly targeting the use of contracts which allow sponsors to ... researchers from different areas who are brought together for several days of intensive discussions about a particular topic ... The 29 meta-analyses reviewed an aggregate of 509 randomized controlled trials (RCTs). Of these, 318 RCTs reported funding ... Standards for Clinical-Trial Agreements with Industry". New England Journal of Medicine. 352 (21): 2202-2210. doi:10.1056/ ...
Walker, BD (2007 Aug-Sep). "Elite control of HIV Infection: implications for vaccines and treatment.". Topics in HIV medicine ... Bradley's Neurology in Clinical Practice: Expert Consult - Online and Print, 6e (Bradley, Neurology in Clinical Practice e- ... placebo-controlled phase 3 trial". The Lancet 381 (9883): 2083-2090. doi:10.1016/S0140-6736(13)61127-7.. ... Evian, Clive (2006). Primary HIV/AIDS care: a practical guide for primary health care personnel in a clinical and supportive ...
Ibanga H, Brookes R, Hill P, Owiafe P, Fletcher H, Lienhardt C, Hill A, Adegbola R, McShane H (2006). "Early clinical trials ... "Centers for Disease Control and Prevention. 2011.. pristupljeno 26. srpnja 2011.. ... 59,0 59,1 59,2 ,National Institute for Health and Clinical Excellence. Clinical guideline 117: Tuberculosis. London, 2011. ... an aid to effective engineering controls and preventive strategies". Am J Infect Control. svezak 26 (broj 4): str. 453.-464. ...
20-year results of a randomized trial". Journal of Clinical Oncology. 32 (8): 791-7. doi:10.1200/JCO.2013.50.6600. PMID ... Wikibooks has a book on the topic of: Radiation Oncology. Information. *Human Health Campus The official website of the ... It may also be used as palliative treatment (where cure is not possible and the aim is for local disease control or symptomatic ... Ang, K. Kian (October 1998). "Altered fractionation trials in head and neck cancer". Seminars in Radiation Oncology. 8 (4): 230 ...
Stradling, J; Roberts, D; Wilson, A; Lovelock, F (1998). "Controlled trial of hypnotherapy for weight loss in patients with ... Handbook of Clinical Neurology. 106. pp. 527-40. doi:10.1016/B978-0-444-52002-9.00031-0. ISBN 978-0-444-52002-9. PMID 22608642. ... "UTCAT2395, Found CAT view, CRITICALLY APPRAISED TOPICs". Retrieved 2016-03-08.. ... who had experienced acute or chronic sleep disorders were put in a randomly controlled trial and their sleep efficiency ( ...
... 0-9. A. B. C. D. E. F. G. H. I. J. K. L. M. N. O. P ... Meeting on the Revision of Guidelines for Clinical Research on Acupuncture, Seoul, Republic of Korea, 24-26 August 2005 : ...
... randomised sham controlled clinical trial BMJ 2018; 361 :k1551 ... What is already known on this topic. *. Owing to conflicting ... the VAPOUR trial is a blinded randomised controlled trial, many differences exist with the former randomised controlled trials ... A randomised sham controlled trial of vertebroplasty for painful acute osteoporotic vertebral fractures (VERTOS IV). Trials2011 ... This trial was a sham controlled, double blind multicentre randomised trial performed at four community hospitals in the ...
... (saffron) on depression and food craving among overweight ... placebo-controlled randomized clinical trial. Participants were randomly assigned into one of the two groups receiving daily ... The demographic and clinical variables at baseline were the same in two groups. Mean depression scores in the saffron group ... Key Research Topics. Substance. Saffron Disease. Depression Overweight Pharmacological Actions. Antidepressive Agents ...
... would you be more inclined to participate in medical trials? ... If you had control over biomedical research and how your data ... Will individual data control entice people to enter clinical trials?. If you had control over biomedical research and how your ... By reaching out to patients online, perhaps participating in clinical trials -- especially when youre looking for experimental ... If you had control over biomedical research and how your data was used, would you be more inclined to participate in medical ...
A Randomized, Single Blind, Controlled Trial of Clinical Outcomes of Dehydrated Human Amnion/Chorion Membrane (dHACM) in Lumbar ... Please find clinical trials at HSS listed by the following topics or view the full directory. ... APS ACTION (Antiphospholipid Syndrome Alliance for Clinical Trials and International Networking) International Clinical ... Please visit the Mary Kirkland Center for Lupus Research and the Lupus Clinical Trials Consortium for more information on lupus ...
Topics. Essays. Records. Articles. ABOUT. What is a fair test?. About the Library. Building the Library. Using the Library. ... Podolsky SH (2008). Jesse Bullowa, specific treatment for pneumonia, and the development of the controlled clinical trial.. ... of the controlled clinical trial as a tool for adjudicating therapeutic efficacy in the emerging era of modern specific ... It stands out as one of the most sophisticated invocations of the controlled clinical trial in the 1920s, and as a self- ...
Study Design.A prospective randomized controlled clinical study.Objective.To investigate the feasibility of a calcium phosphate ... Clinical Trial of Balloon Kyphoplasty Comparing Calcium Phosphate Versus Polymethylmethacrylate ... Study Design.A prospective randomized controlled clinical study.Objective.To investigate the feasibility of a calcium phosphate ... Suitability of a Calcium Phosphate Cement in Osteoporotic Vertebral Body Fracture Augmentation: A Controlled, Randomized, ...
Prospective, randomized, controlled clinical trial comparing traditional versus reduced tidal volume ventilation in acute ... Failure to observe beneficial effects of small tidal volume ventilation treatment in important clinical outcome variables may ...
Reviews on recent clinical trials. Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders and it ... Randomized Controlled Trials as Topic. *Rifamycins. *Rifamycins: therapeutic use. Get free article suggestions today. Mendeley ... As a result, clinical trials have focused, for the most part, on one IBS subtype. Over the past 2 decades very few agents have ...
Controlled Clinical Trials as Topic* * Evaluation Studies as Topic * Female * Humans * Male ... The problems associated with scoring trials are discussed and further work to increase the scope of scoring mechanisms is ...
Controlled Clinical Trials as Topic * Endothelium / drug effects * Fatty Acids, Omega-3 / pharmacology* ...
Randomized Controlled Trials as Topic. Messer K, Vaida F, Hogan C. "Robust analysis of biomarker data with informative ... missingness using a two-stage hypothesis test in an HIV treatment interruption trial: AIEDRP AIN503/ACTG A5217." Contemp Clin ... of biomarker data with informative missingness using a two-stage hypothesis test in an HIV treatment interruption trial: AIEDRP ... of biomarker data with informative missingness using a two-stage hypothesis test in an HIV treatment interruption trial: AIEDRP ...
Randomized Controlled Trials as Topic. Geng EH, Kahn JS, Chang OC, et al. "The effect of AIDS Clinical Trials Group Protocol ... Geng EH, Kahn JS, Chang OC, et al. "The effect of AIDS Clinical Trials Group Protocol 5164 on the time from Pneumocystis ... Geng EH, Kahn JS, Chang OC, et al. "The effect of AIDS Clinical Trials Group Protocol 5164 on the time from Pneumocystis ... Geng EH, Kahn JS, Chang OC, et al. "The effect of AIDS Clinical Trials Group Protocol 5164 on the time from Pneumocystis ...
Weight Control: MedlinePlus Health Topic (National Library of Medicine) Also in Spanish ... Article: Changes in Clinical Characteristics and Outcomes of Patients Admitted to Inpatient... ... High Blood Pressure: MedlinePlus Health Topic (National Library of Medicine) Also in Spanish ... Page last updated on 2 August 2021 Topic last reviewed: 13 April 2016 ...
... randomized-controlled pilot trial that will randomize 170 patients undergoing coronary artery bypass graft surgery to early ( ... Please refer to this study by its identifier (NCT number): NCT01063491 ... MedlinePlus related topics: Coronary Artery Bypass Surgery U.S. FDA Resources Further study details as provided by Emmanouil ... Cardiac CAtheterization for Bypass Graft Patency Rate Optimization: the CABG-PRO Randomized-controlled Pilot Study (CABG-PRO). ...
Interventional (Clinical Trial) Actual Enrollment :. 176 participants. Allocation:. Randomized. Intervention Model:. Factorial ... MedlinePlus related topics: Cholesterol Medicines Drug Information available for: Niacin Niacinamide Sevelamer Sevelamer ... European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of ... Randomized controlled trial on the efficacy and safety of atorvastatin in patients with type 2 diabetes on hemodialysis (4D ...
Clinical Pregnancy Rate [ Time Frame: 6 months ]. Number of women with clinical pregnancies /number of women randomized to the ... MedlinePlus related topics: Infertility Drug Information available for: Metformin Metformin hydrochloride U.S. FDA Resources ... Effect of Lifestyle and/or Metformin Intervention on Pregnancy Outcome, A Pilot Randomized Controlled Trial. The safety and ... No Intervention: routine clinical education group Subjects will only accept clinical routine education after assigned to ...
Interventional (Clinical Trial) Actual Enrollment :. 742 participants. Allocation:. Randomized. Intervention Model:. Parallel ... MedlinePlus related topics: Birth Control Drug Information available for: Levonorgestrel U.S. FDA Resources ... Identifier:. NCT00185380 Other Study ID Numbers:. 91412 2004-002291-42 ( EudraCT Number ). 308901 ( Other ... Bayer Schering Pharma AG, Germany is the sponsor of the trial.. Although the title of the study describes open, it was in ...
Consumer News Products News types News Topics Adolescents / Teens Behavior Coronavirus Diabetes: Type I Kids Ailments ... A-Z of Wellness TopicsAgingAlzheimersArthritisAsthma and AllergiesBaby and Child CareCancerChildrens HealthDental Health ... The research team compared how well 180 children and teens in two U.K. communities controlled their type 1 diabetes in the 12 ... communicate well and work as a team to prevent related long-term health problems that are caused by poor blood glucose control ...
Topics include introduction to epidemiology; design of cohort and case-control studies; experimental versus observational data ... design of clinical trials; data monitoring and interim analysis. Prerequisite: STAT 450 or permission of the instructor. ... STAT 290 - Selected Topics in Probability and Statistics (3) Topics in areas of probability and statistics not covered in the ... STAT 390 - Selected Topics in Probability and Statistics (3) Topics in areas of probability and statistics not covered in the ...
A Quality Control Program for Quantitative MRI DataAcquisition and Analysis in Multi-site Clinical Trials SBC: CaliberMRI, Inc. ... Topic: 101 Project Summary Abstract There has been a shift to greater use of neadjuvant chemotherapyNACTin the clinical ... SBC: Dream Face Technologies, LLC Topic: NIA The objective of the proposed direct Phase II SBIR project is to develop and study ... SBC: BIOMIMETIX JV LLC Topic: 102 Ischemic stroke is a leading cause of death and disability in the United StatesThis often is ...
Clinical Trials as Topic. Energy Metabolism*. Fat Emulsions, Intravenous*. Female. Gastrointestinal Diseases / metabolism*, ... Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Govt ... Glucose or fat as a nonprotein energy source? A controlled clinical trial in gastroenterological patients requiring intravenous ...
Clinical Trials as Topic. Endarterectomy, Carotid*. Humans. Patient Selection. Randomized Controlled Trials as Topic. Stents*. ... However, more recent trials have shown that CAS might be considered an effective alternative to CEA. Moreover, the rapid ... Purpose of this review is to discuss the most recent clinical evidences concerning the treatment of carotid artery stenosis, ...
Clinical decision support systems (CDSS) are being applied widely in patient safety, most frequently to provide alerts intended ... Evaluating alert fatigue over time to EHR-based clinical trial alerts: findings from a randomized controlled study.. ... Evaluating alert fatigue over time to EHR-based clinical trial alerts: findings from a randomized controlled study. Journal of ... This study of an alert within an electronic medical record designed to encourage participation in a clinical trial is relevant ...
Travelers Health: Diphtheria (Centers for Disease Control and Prevention) Clinical Trials * Diphtheria ( ... Tetanus, Diphtheria, and Pertussis Vaccines: MedlinePlus Health Topic (National Library of Medicine) Also in Spanish ... About Diphtheria (Centers for Disease Control and Prevention) Also in Spanish * Diphtheria (Medical Encyclopedia) Also in ... Diphtheria Complications (Centers for Disease Control and Prevention) * Diphtheria Diagnosis and Treatment (Centers for Disease ...
Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 - Clinical Trials ... controlled cohort study, clinical efficacy or effectiveness study, or a pragmatic trial. The data collected should be used to ... Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 Clinical Trial Required ... Clinical Trial Planning Phase - Exploratory Clinical Trials (current FOA). To maximize the impact of Mind and Body clinical ...
What is already known about this topic?. Clinical trials have demonstrated the efficacy of COVID-19 vaccines in a controlled ... Clinical trials have demonstrated the efficacy of COVID-19 vaccines in preventing mild and severe COVID-19 in a controlled ... However, clinical trials are not designed to assess the population impact of vaccination in a real-world setting (1,2). Israel ... Polack FP, Thomas SJ, Kitchin N, et al.; C4591001 Clinical Trial Group. Safety and efficacy of the BNT162b2 mRNA Covid-19 ...
The aims of this randomised controlled trial are to estimate (1) the clinical effectiveness of three methods of providing ... methods and operational aspects of a clinical trial of acute injury management in the emergency department. ... Clinical and cost effectiveness of mechanical support for severe ankle sprains: design of a randomised controlled trial in the ... The aims of this randomised controlled trial are to estimate (1) the clinical effectiveness of three methods of providing ...
Clinical Trial Outlook 2025 report has been added to ResearchAndMarkets.coms offering. This report on the Controlled Release ... The Global Controlled-Release Drug Delivery Market - Opportunity & ... Global Controlled Drug Delivery Market Future Outlook Key Topics Covered: 1. Drug Delivery: An Advancing Trajectory ... Global Controlled Release Drug Clinical Pipeline by Phase, Indication, Drug Class * Global Controlled Release Drug Clinical ...
Randomized controlled trials on diet and shortening of leukocyte telomere length (LTL) mostly focus on marine-derived n-3 ... parallel trial. A sub-set of the Barcelona site participants were randomly assigned to the walnut (n = 80) or control group (n ... Results of a Randomized Controlled Trial. Freitas-Simoes TM, Cofán M, Blasco MA, Soberón N, Foronda M, Serra-Mir M, Roth I, ... control, walnut) and their interaction. Adjusted means (95% confidence interval) of LTL (in kb) in controls were 7.360 (7.084, ...
  • Conflicts of Interest and Outcomes of Cardiovascular Trials. (
  • Young adults with asthma experienced improved clinical outcomes after undergoing virtual care, known as a multi-level EMR-integrated smartphone-telemedicine program. (
  • Outcomes included the number of recurrent urinary tract infections during the trial, the proportion of patients without recurrent urinary tract infections, consumption of antibacterials, the presence of dysuria at final visit, leukocyturia, bacteriuria and safety. (
  • Secondary outcomes were changes in clinical signs and occurrence of side effects. (
  • Prognostic biomarkers classify patients treated with standard therapies-including no treatment, if that is standard practice-into subgroups with distinct expected clinical outcomes. (
  • Primary outcomes were clinical failure rates at 7 to 15 days and 16 to 60 days follow-up. (
  • There is moderate evidence that antibiotics provide a small benefit for clinical outcomes in immunocompetent primary care patients with uncomplicated acute sinusitis . (
  • The effect of AIDS Clinical Trials Group Protocol 5164 on the time from Pneumocystis jirovecii pneumonia diagnosis to antiretroviral initiation in routine clinical practice: a case study of diffusion, dissemination, and implementation. (
  • What is the quality of clinical practice guidelines for the treatment of acute lateral ankle ligament sprains in adults? (
  • The PATAF trial was a prospective, randomized trial to investigate the effectiveness of aspirin and coumarin in preventing thromboembolism in patients with non-rheumatic atrial fibrillation in general practice. (
  • Expert consensus statements regarding the use and tapering of oral corticosteroids may be used to help inform treatment in clinical practice and to optimize the management of patients with severe asthma. (
  • They did note whether trials were carried out under good clinical practice, whether an intention-to-treat (ITT) analysis had been performed, and if analysis had been per protocol. (
  • Three trials were reported as performed under good clinical practice. (
  • During the spring of 2004, the National Heart, Lung, and Blood Institute (NHLBI) began planning for the development of clinical practice guidelines for VWD in response to the FY 2004 appropriations conference committee report (House Report 108-401) recommendation. (
  • Likewise in 2014, the use of metoclopramide (MCP) and domperidone in functional GI disorders (FGID) was restricted, consequently leaving a therapeutic gap in clinical practice. (
  • The obesity-asthma phenotype has become an increasingly common situation in our clinical practice. (
  • However, there are limited data to suggest proper repletion regimens for those patients who have hypovitaminosis D. Consequently, various methods are used in clinical practice. (
  • Clinical trials have demonstrated the efficacy of COVID-19 vaccines in a controlled setting. (
  • Clinical trials have demonstrated the efficacy of COVID-19 vaccines in preventing mild and severe COVID-19 in a controlled setting. (
  • As the goal of any drug delivery system is to provide a therapeutic amount of drug to a proper site in the body so that the desired drug concentration can be achieved promptly and then maintained, all these characteristics are provided by controlled drug delivery technologies. (
  • Controlled drug delivery systems provide uniform concentration of drug to the absorptions site and thus allow the maintenance of plasma concentration within the therapeutic range which minimizes not only the side effects but also the frequency of administration. (
  • The purpose of this FOA is to solicit research applications to conduct Phase II clinical therapeutic trials that have the potential to advance development of novel therapies for a lung disease or a cardiopulmonary disorder of sleep. (
  • Study Design: Randomized controlled trials, cohort, and case-control studies. (
  • Eligible studies were randomised, placebo-controlled clinical trials (RCTs) of bacterial lysate immunostimulants with the primary aim of reducing the number of recurrent urinary tract infections over a period of six to 12 months. (
  • STW 5 is the only HMP for which efficacy has been shown in randomized controlled clinical trials (RCTs) in functional dyspepsia and irritable bowel syndrome, based on its multitarget effect on numerous etiological factors. (
  • The quality of randomised controlled trials (RCTs) was evaluated using the Jadad scale, which assesses the adequacy of randomisation, double blinding, and withdrawals or dropouts. (
  • Considers the aerosol or foodborne dissemination of botulinum toxin and provides a variety of facts about botulism/botulinum toxin, including its history as a bioweapon, microbiology, pathogenesis/clinical manifestation, epidemiology, diagnosis, therapy, prophylaxis, and decontamination. (
  • Subcutaneous or sublingual immunotherapy should be considered if usual treatments do not adequately control symptoms and in patients with allergic asthma. (
  • Many lung diseases are managed by controlling symptoms, but lack proven pharmacologic or immuno-modulating treatments. (
  • Lower amounts of oral SAMe have also produced reductions in the severity of osteoarthritis symptoms in preliminary clinical trials. (
  • A two-year, uncontrolled trial showed significant improvement of symptoms after two weeks at 600 mg SAMe daily, followed by 400 mg daily thereafter. (
  • In this six-week, placebo-controlled trial, both fixed doses of LATUDA 80 and 160 mg once-daily, demonstrated statistically significant improvement in symptoms of schizophrenia versus placebo across both primary and secondary efficacy measures. (
  • Omalizumab was associated with beneficial effects on asthma control and symptoms, and the likelihood of requiring new OCS prescriptions. (
  • Five studies at low risk of bias comparing penicillin or amoxicillin to placebo provided information on the main outcome: clinical failure rate at 7 to 15 days follow-up, defined as a lack of full recovery or improvement, for participants with symptoms lasting at least seven days. (
  • Six subjects were randomly assigned to BCG or placebo and compared to self, healthy paired controls (n = 6), or reference subjects with (n = 57) or without (n = 16) type 1 diabetes, depending on the outcome measure. (
  • Impact of Funding Source on Clinical Trial Results Including Cardiovascular Outcome Trials. (
  • Conditional power calculations suggested a less than 2% chance that the curcuminoids group would have a significantly better outcome as compared with the placebo group if the trial were continued to completion. (
  • The authors' objective was to evaluate and quantify the effects of dexmedetomidine (0.2 μg·kg -1 ·h -1 ) on local field potentials in patients with Parkinson disease undergoing deep brain stimulation surgery compared with control recording (primary outcome), as well as the effect of propofol at different estimated peak effect site concentrations (0.5, 1.0, 1.5, 2.0, and 2.5 μg/ml) from control recording. (
  • Recently, the possible impacts on clinical outcome of tissue injury, inflammation, and variations in hypertrophy and chamber remodeling have been increasingly understood. (
  • Translating preclinical findings to humans, the investigators administered BCG, a generic vaccine, in a proof-of-principle, double-blind, placebo-controlled trial of adults with long-term type 1 diabetes (mean, 15.3 years) at one clinical center in North America. (
  • Clinical trials are a group of biomedical or behavioral efficacy and safety studies, completed in humans, that are usually broken down in to four phases. (
  • By reaching out to patients online, perhaps participating in clinical trials -- especially when you're looking for experimental treatments for uncommon diseases -- will become a clearer, less confusing process. (
  • The CEO of the ALF is also planning to trial a project which will place liver disease patients into the Reg4All system. (
  • The Cardiac CAtheterization for Bypass Graft Patency Rate Optimization (CABG-PRO) randomized-controlled pilot study is a phase III, double-blind, randomized-controlled pilot trial that will randomize 170 patients undergoing coronary artery bypass graft surgery to early (before dismissal) graft angiography vs. no early graft angiography. (
  • The comparison between nicotinamide and sevelamer aims to demonstrate, in chronic hemodialysed patients, the non-inferiority of nicotinamide in terms of control of the phosphatemia. (
  • The purpose of pilot trial is to compare the efficacy of lifestyle intervention, metformin intervention, lifestyle combined with metformin intervention in improving assisted reproductive technology in non-polycystic ovary syndrome(pcos) patients with overweight/obesity and insulin resistance compared with conventional clinical education. (
  • A controlled clinical trial in gastroenterological patients requiring intravenous nutrition. (
  • neurodegenerative diseases including Alzheimer's disease, today announced that it has initiated dosing in the final patient in its randomized, double-blinded, placebo-controlled, Phase 2 study in moderate to severe Alzheimer's disease patients. (
  • This combined mechanism of action through PKC epsilon activation gave the Company the confidence to commit to these trials in moderate to severe patients," said Dr. Susanne Wilke , PhD., the Company's Chief Executive Officer. (
  • Across all measures, the proportion of patients that improved on both statistical and clinical criteria for meaningful improvement was at least twofold greater among efalizumab -treated patients than in placebo-treated patients. (
  • Treatment with dupilumab led to significant improvements in lung function by 16 weeks and up to 24 weeks in patients with chronic rhinosinusitis with nasal polyps and comorbid asthma plus clinical features of COPD. (
  • Human clinical trials have investigated aromatherapy primarily in the treatment of stress and anxiety in patients with critical illnesses or in other hospitalized patients. (
  • Several clinical trials involving patients with cancer have been published. (
  • Data were extracted from each trial on the number of recurrent urinary tract infections, proportion of patients without recurrent urinary tract infections, consumption of antibacterials for recurrent urinary tract infections, and incidence of adverse events. (
  • MR889, a neutrophil elastase inhibitor, in patients with chronic obstructive pulmonary disease: a double-blind, randomized, placebo-controlled clinical trial. (
  • The study was a double-blind, randomized, placebo-controlled clinical trial in COPD patients. (
  • Rösch W, Vinson B, Sassin I. A randomised clinical trial comparing the efficacy of a herbal preparation STW 5 with the prokinetic drug cisapride in patients with dysmotility type of functional dyspepsia. (
  • A review of the clinical trials on SAMe concluded that its efficacy against osteoarthritis was similar to that of conventional drugs but that patients tolerated it better. (
  • MARLBOROUGH, Mass.--(BUSINESS WIRE)--Dec 8, 2010 - Sunovion Pharmaceuticals Inc. (Sunovion) today announced the results of the PEARL 3 study, the third phase 3 worldwide clinical trial of Latuda ® (lurasidone HCl) tablets, a once-daily atypical antipsychotic agent recently approved by the U.S. Food and Drug Administration (FDA) for the treatment of patients with schizophrenia. (
  • The PEARL 3 study ( P rogram to E valuate the A ntipsychotic R esponse to L urasidone) was part of an extensive worldwide clinical development program involving more than 2,900 subjects, which evaluated the safety and efficacy of LATUDA for the treatment of adult patients with schizophrenia. (
  • The PEARL 3 study was a double-blind, fixed-dose, placebo-controlled, six-week clinical trial involving 488 patients with schizophrenia and was conducted at 64 sites worldwide. (
  • In this study, patients treated with just one dose per week of BYDUREON for four years experienced sustained improvement in glycemic control and showed reductions in certain cardiometabolic measures. (
  • Following the controlled portion of the study, 258 of the 295 intent-to-treat patients (87 percent) entered the extension study. (
  • Thus by intersecting both these areas of research, we can produce optimised differentiation systems for the production of universal platelets, thus offering a stable supply of platelets for difficult-to-match patients and providing areas with transmissible disease concerns or an unpredictable supply of platelets with a steady supply of quality-controlled platelet units. (
  • A nonrandomized, nonblinded controlled clinical trial was carried out to assess the change in local field potentials activity over time in 10 patients with Parkinson disease who underwent deep brain stimulation placement surgery (18 subthalamic nuclei). (
  • Body mass index (BMI) and asthma control status of the patients were evaluated. (
  • Asthma control was poor in the patients who were obese and overweight despite optimal treatment. (
  • Moreover, asthma control was worse in patients who gained weight during the follow-up period. (
  • The goal of the Proceedings is to publish articles with a predominantly clinical focus which directly impact quality of care for patients with allergic disease and asthma and by having the potential to directly impact the quality of patient care. (
  • In the post- versus preindex period, the patients were significantly more likely to have well-controlled asthma (odds ratio [OR] 1.72 [95% confidence interval {CI}, 1.11‐2.64]) and less likely to have a lung function value below normal (nonsignificant) after omalizumab initiation. (
  • The OHSU Women's Health Research Unit is actively recruiting patients for clinical trials in a variety of women's health topics. (
  • I have been following this interesting molecule for a while now, and I am delighted to report that finally it is going to be in formal clinical trials for CLL patients. (
  • Reduction in costs and timings of early phase clinical trials can mean lower recruitment of patients and improve the overall clinical accuracy. (
  • He started out by grounding his controlled study in the particularities of studying pneumonia. (
  • A prospective randomized controlled clinical study. (
  • Evaluating alert fatigue over time to EHR-based clinical trial alerts: findings from a randomized controlled study. (
  • This study of an alert within an electronic medical record designed to encourage participation in a clinical trial is relevant for CDSS designers, as it quantifies the degree of alert fatigue. (
  • This funding opportunity is intended to support feasibility clinical trials, which will provide data that are critical for the planning and design of a subsequent controlled cohort study, clinical efficacy or effectiveness study, or a pragmatic trial. (
  • This report on the "Controlled Release Drug Delivery Market" is a result of intensive study of the novel segment and its future market potential. (
  • This opportunistic sub-study was conducted within the Walnuts and Healthy Aging study, a dual-centre (Barcelona, Spain and Loma Linda University, California) parallel trial. (
  • Identifying Barriers and Practical Solutions to Conducting Site-Based Research in North America: Exploring Acute Heart Failure Trials As a Case Study. (
  • Study Design: Randomized placebo-controlled trials. (
  • Study Design: Case-control studies and prospective studies. (
  • If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. (
  • In addition, each application must include at least one basic research ancillary study tightly related to the clinical question. (
  • Each application will propose one Phase II interventional trial that will most likely use physiological or biochemical rather than clinical endpoints along with at least one smaller basic ancillary research study that is tightly related to the clinical question. (
  • Staff from NIDA's Clinical Trials Network collaborated in the design and conduct of the study, assisted with data management and quality assurance during the trial, and provided comments for consideration on this manuscript. (
  • Clinical researchers in Italy addressed this topic by using a well-designed study protocol. (
  • In our study, we found a significant relationship between obesity and asthma control. (
  • This study aim to summarize the AEs caused by T. wilfordii tgpolyglycoside (TWP), the most common preparation of T. wilfordii Hook F for clinical use. (
  • We set this study to review the literature systematically, to identify the proposed trial designs, and to develop a classification scheme. (
  • In each eligible article, we identified the trial designs presented and extracted the term used for labeling the design, components of patient flow (marker status of eligible participants, intervention, and comparator), study questions, and analysis plan. (
  • This study aimed to determine if stretching exercise can be implemented as an adequate control therapy in exercise randomized controlled trials aimed at improving physical fitness and physical function in older adults. (
  • The purpose of this study is to better understand how birth control pills affect the risk of blood clots. (
  • On this BSc Mathematics with Statistics degree you'll study core maths topics such as algebra and calculus. (
  • and 3.6 million high school and middle school students now use e-cigarettes, according to U.S. Centers for Disease Control and Prevention data released late last year, NBC News reported. (
  • On September 11, 2001, following the terrorist incidents in New York City and Washington, DC, the Centers for Disease Control and Prevention (CDC) recommended heightened surveillance for any unusual disease occurrence or increased numbers of illnesses that might be associated with the terrorist attacks. (
  • Centers for Disease Control and Prevention (CDC) Morbidity and Mortality Weekly Report (MMWR) 50(41);893-7, (October 19, 2001). (
  • This brief fact sheet provides information about the risks of prescription opioid pain relievers and a summary of the Centers for Disease Control and Prevention's Guideline for Opioid Prescribing for Pain. (
  • The research team compared how well 180 children and teens in two U.K. communities controlled their type 1 diabetes in the 12 weeks before and the 12 weeks after the lockdown began on March 23, 2020. (
  • The primary endpoint of the trial is the Severe Impairment Battery (SIB) and the secondary endpoints are the Mini Mental State Exam (MMSE), Activity of Daily Living (ADL) and Neuropsychiatric Inventory scale (NPI). (
  • Results from three randomized, placebo-controlled clinical trials of moderate to severe plaque psoriasis. (
  • Children with severe or poorly controlled asthma with allergen sensitization have been shown to experience more asthma exacerbations and use more oral corticosteroids compared with those without allergen sensitization. (
  • Effects of an oral MMP-9 and -12 inhibitor, AZD1236, on biomarkers in moderate/severe COPD: a randomised controlled trial. (
  • The incidence of hypoglycemia in various trials reviewed in this article depends on the definitions of mild, moderate, and severe hypoglycemia. (
  • Most recent large trials have defined severe hypoglycemia as severe, whenever help from a third party is required, whereas mild episodes are those that are self-treated (supplementary Table 1 reports severe episodes). (
  • Clinical trials in irritable bowel syndrome: a review. (
  • Treatment of irritable bowel syndrome with herbal preparations: results of a double-blind, randomized, placebo-controlled, multi-centre trial. (
  • He also has roles as a consultant advisor at NETSCC, leading on surgery and interventional procedures for the NIHR Health Technology Assessment programme, and providing clinical and scientific advice to the NIHR Public Health Research programme. (
  • Eight of the studies were interventional/randomized controlled trials, and 11 examined general mental health issues. (
  • A sub-set of the Barcelona site participants were randomly assigned to the walnut ( n = 80) or control group ( n = 69). (
  • In an 18-month weight-loss trial, 278 participants with abdominal obesity/dyslipidemia were randomized to low-fat (LF) or Mediterranean/low-carbohydrate (MED/LC + 28 g walnuts/day) diets with/without moderate physical activity. (
  • The included trials were preliminary studies with small numbers of participants. (
  • Participants were 346 women recruited from and receiving treatment at six community-based drug treatment programs participating in NIDA's Clinical Trials Network. (
  • Participants were randomized to receive 12-sessions of either seeking safety (SS), a cognitive behavioral intervention for women with PTSD and SUD, or women's health education (WHE), an attention control psychoeducational group. (
  • This amount was also used in a double-blind trial, but participants first received five days of intravenous SAMe. (
  • Forty-six studies, comprising 25 randomized controlled trials, 13 controlled clinical trials, and 8 single-arm trials, were included in this meta-analysis, representing 2437 enrolled TWP-treated participants. (
  • nine placebo-controlled studies involving 1915 participants (seven of the studies clearly conducted in primary care settings) and 54 studies comparing different classes of antibiotics (10 different comparisons). (
  • In these studies antibiotics decreased the risk of clinical failure (pooled RR of 0.66, 95% CI 0.47 to 0.94, 1084 participants randomised, 1058 evaluated, moderate quality evidence). (
  •,viruses%20in%20the%20same%20family.&text=Nipah%20virus%20is%20a%20type,transmitted%20from%20animals%20to%20humans. (
  • The report has been made with key focus on the current market trends, superiority of Controlled Drug Delivery methods to traditional drug delivery methods. (
  • General methodological limitations included the use of non-equivalent control groups, a lack of linking pre- and post-test samples in multiple cross-sectional surveys, assessment immediately post-intervention, unclear methods used for statistical comparisons, and inappropriate analysis of cluster trials. (
  • The article describes the appropriate use of USP General Chapters related to chromatographic methods and controls for contaminants. (
  • Owing to the adverse effects (AEs) of TwHF in clinical preparations, methods for reducing the toxicity and increasing the efficacy of TwHF are being extensively investigated. (
  • Prospective, randomized, controlled clinical trial. (
  • Intensive glucose control invariably increases the risk of hypoglycemia and sometimes the severity of hypoglycemia ( 2 ) Several epidemiological studies and smaller prospective studies have linked hypoglycemia to increased cardiovascular risk ( 3 ⇓ - 5 ). (
  • Randomised and non-randomised controlled trials, and prospective and retrospective case series were eligible for inclusion if they were of children and adolescents (aged under 18 years) with migraine diagnosed by established diagnostic criteria (specified in the review). (
  • Their design often differs from the more conventional comparative clinical trials of interventions. (
  • The interventions, compared with the controls, significantly improved balance and knee strength parameters. (
  • Titration phase with sevelamer (Renagel) with the aim of phosphatemia control in 4 weeks of treatment, with stable dose of calcic carbonate. (
  • The goal of this funding opportunity is to support early phase clinical trials of mind and body approaches for conditions that have been identified by NCCIH as high priority research topics. (
  • This Funding Opportunity Announcement (FOA) issued by the National Heart, Lung, and Blood Institute, National Institutes of Health, solicits grant applications from institutions/organizations to conduct proof-of- concept Phase II clinical trials that test a novel intervention for a lung disease or a cardiopulmonary disorder from sleep that has the potential to significantly change clinical management. (
  • Although definitive Phase III trials will not be supported, the proposed studies must provide proof of concept for a novel intervention that has high potential for modifying current treatments and could be disease modifying. (
  • Phase I clinical trials test a treatment's safety, dosage range and side effects in a small group of healthy people to determine if a treatment can be checked for efficacy. (
  • Phase III clinical trials are administered to a larger group of people to finally verify efficacy and safety. (
  • Does Superior Volunteer Management Help Achieve Endpoints and Objectives in Phase I Trials? (
  • Design Randomised, double blind, sham controlled clinical trial. (
  • In these diseases, the clinical picture of acute aortic regurgitation results from a sudden and marked increase in diastolic filling volume, with no chance for the left ventricle or the stiff pericardium to accommodate this increase. (
  • We included trials with clinically diagnosed acute sinusitis , confirmed or not by imaging or bacterial culture. (
  • Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. (
  • Studies with a control group were eligible for inclusion. (
  • Sixteen controlled studies (n=14,682) were included. (
  • This summary includes a brief history of aromatherapy, a review of laboratory studies and clinical trials, and possible adverse effects associated with aromatherapy use. (
  • However, the association between glycemic control and macrovascular disease is mainly obtained from epidemiological studies, and intensive glucose control has often failed to reduce macrovascular events. (
  • While the reason for the increased mortality is unclear and hypoglycemia has not been implicated as a cause of death, these studies have increased the debate about the degree of glycemic control required to decrease diabetes complications and the role of hypoglycemia in cardiovascular morbidity and mortality. (
  • Dr Cook works with both the Southampton Clinical Trials Unit, and the NIHR Evaluation Trials and Studies Coordinating Centre (NETSCC). (
  • His externally funded research is mostly in the realm of surgery, including a randomised trial on the mangement of developmental hip dysplasia, and cohort studies on the management of complex aortic aneurysms in both the thorax and the abdomen. (
  • Trials Unit Lead for non-cancer studies. (
  • This makes retrieval, interpretation, comparison, and critical appraisal of these types of studies complicated for consumers of trial results, who can be practicing physicians, researchers, or policymakers. (
  • Which clinical studies provide the best evidence? (
  • Through their in-depth case studies and presentations delegates will learn how to implement an adaptive design clinical trial for their own drug development, from initial processes in managing trials to choosing the right time to implement change. (
  • We searched CENTRAL 2013, Issue 2, MEDLINE (1946 to March week 3, 2013), EMBASE (1974 to March 2013), SIGLE (OpenSIGLE, later OpenGrey (accessed 15 January 2013)), reference lists of the identified trials and systematic reviews of placebo-controlled studies. (
  • In meta-analyses of the placebo-controlled studies, we combined data across antibiotic classes. (
  • There are a wide range of topics covered in our clinical trial webinars - from tips on clinical trial start-up and adaptive trials to risk-based monitoring and best practices for clinical trial enrollment. (
  • Clinical trials run by pharmaceutical and biotech companies have undergone major changes, implementing adaptive designs to tailor a trial. (
  • Successful implementation of adaptive designs into a trial however requires unparalleled coordination between clinicians, trial managers, statisticians and those involved in external and internal regulation. (
  • SMi's Adaptive Designs in Clinical Trials conference returns to London in April for the 5th year running. (
  • Pharma companies of all sizes will disclose how they have successfully implemented trials incorporating adaptive designs. (
  • Adaptive sample size and modification in clinical trials: start small then ask for more? (
  • The Office of Prevention, Education, and Control (OPEC) of the NHLBI coordinated the Panel. (
  • The meta-analysis only in the controls resulted in significant improvements in different functional parameters related to walking, balance, knee flexion strength, or global physical function. (
  • This randomized clinical trial will compare surgical decompression versus nonsurgical treatment (i.e., physical therapy) of lumbar spinal stenosis. (
  • However, clinical trials are not designed to assess the population impact of vaccination in a real-world setting ( 1 , 2 ). (
  • Statistical analysis to assess changes in vitamin D level controlling for season, comorbidities, and demographics were used. (
  • Change control can be described as a set of six steps: Plan / Scope Assess / Analyze Review / Approval Build / Test Implement Close Consider the primary and ancillary details of the proposed change. (
  • In addition, both LATUDA dose groups were significantly more effective than placebo on the Clinical Global Impressions Severity scale (CGI-S), the key secondary efficacy endpoint, as early as week one. (
  • Economic return of clinical trials performed under the pediatric exclusivity program. (
  • ASTHMAXcel Adventures is a gamified, guideline-based, pediatric mobile application that improves asthma control, knowledge, and quality of life, and reduces emergency department visits. (
  • Is Stretching Exercise An Adequate Control Group in Clinical Trials Aimed at Improving Physical Fitness and Function of Older Adults? (
  • Five electronic databases were systematically searched for randomized controlled trials focused in the physical fitness and function of older adults using stretching exercise as control group. (
  • Will individual data control entice people to enter clinical trials? (
  • If you had control over biomedical research and how your data was used, would you be more inclined to participate in medical trials? (
  • Jesse Bullowa's 1928 report on the use of antipneumococcic serum in lobar pneumonia ( Bullowa 1928a ) was subtitled "Data necessary for a comparison between cases treated with serum and cases not so treated, and the importance of a significant control series of cases. (
  • and use of data from randomized trials. (
  • Complexities in sample handling, instrument setup and data analysis are barriers to the effective use of flow cytometry to monitor immunological parameters in clinical trials. (
  • Access to patient-level data from GlaxoSmithKline clinical trials. (
  • Bumps and bridges on the road to responsible sharing of clinical trial data. (
  • BACKGROUND: Sharing data from clinical trials could assist with the advancement of science and medicine, potentially providing a better understanding of both the benefits and risks of medicines and other treatments. (
  • The characteristics of data monitoring and the need for the use of data monitoring committees in clinical trials sponsored by the pharmaceutical industry differ from those of trials sponsored by government. (
  • Josh Silverman , Chairman of the Company, added, "We are pleased with the investor response to our new management team and the excitement surrounding our upcoming clinical data. (
  • They should be prescribed effectively and appropriately based on data from controlled clinical trials. (
  • Pharma and biotech companies are pushing the envelope with where they store data, how they collaborate with institutions for clinical trials, and how they build technology in medical devices. (
  • and clinical trials data protection. (
  • Finally, given the volume of available clinical data and the paucity of drugs developed solely for VHD, we will present animal or experimental data only when they importantly supplement clinical information ( Table ). (
  • Two review authors independently screened search results, extracted data and assessed trial quality. (
  • Introduces clinical trial design in the context of epidemiological concepts, covers various topics in the design and conduct of clinical trials, and profiles clinical trials that illustrate these issues. (
  • Conflicts of interests have long been recognized as potential sources of influence in the conduct and reporting of clinical trials. (
  • Subjects who meet the inclusion criteria will be randomized to four groups: lifestyle intervention group, metformin intervention group, lifestyle combined with metformin intervention group, and routine clinical education group. (
  • Subjects of above three intervention group will start ovulation stimulation treatment after reach the aim or duration of intervention and routine clinical education group has no intervention. (
  • examining acceptability of the intervention and control conditions. (
  • In the CENTRAL 18-month intervention trial, a Mediterranean/low-carbohydrate diet induced a greater decrease in hepatic fat content than a low-fat diet, conferring beneficial health effects that were beyond the favorable effects of visceral fat loss. (
  • Stretching exercise as control therapy in older people can lead to beneficial effects and could influence the interpretation of the effect size in the intervention groups. (
  • We calculated risk ratios (RRs) for differences between intervention and control groups in whether the treatment failed or not. (
  • This exploratory research finding should be confirmed in trials with adequate statistical power. (
  • The benefit of glycemic control in decreasing the risk for microvascular disease is well established. (
  • However, the role of glycemic control in decreasing macrovascular complications has been controversial. (
  • The link between glycemic control and microvascular complications has been firmly established ( 1 , 2 ). (
  • BYDUREON works with the body to help make its own insulin when needed, providing continuous glycemic control with just one dose per week. (
  • It also makes insulin and other hormones that help control your blood sugar. (
  • Endocrine (say "EN-doh-krin") cells make insulin. (
  • Individuals with prediabetes demonstrate some amount of insulin resistance, that is, the insulin produced by the body is not very effective in controlling blood glucose levels. (
  • In the early stages, this insulin resistance can be reversed or, in other words, the insulin sensitivity can be increased by lifestyle changes like controlling diet, weight and regular exercise. (
  • Treatment with Sildenafil Improves Insulin Sensitivity in Prediabetes: A Randomized, Controlled Trial. (
  • The Expert Panel members were selected to provide expertise in basic sciences, clinical and laboratory diagnosis, evidence-based medicine, and the clinical management of VWD, including specialists in hematology as well as in family medicine, obstetrics and gynecology, pediatrics, internal medicine, and laboratory sciences. (
  • Dr. Barbara Alving, Acting Director of the NHLBI, gave the charge to the Expert Panel to examine the current science in the area of VWD and to come to consensus regarding clinical recommendations for diagnosis, treatment, and management of this most common inherited bleeding disorder. (
  • Seventy-three women with BMI ≥ 25 comorbid with mild-to-moderate depression were recruited in this 12-week double-blind, placebo-controlled randomized clinical trial. (
  • A randomized, placebo-controlled, double-blind clinical trial of curcuminoids in oral lichen planus. (
  • A randomized, double-blind, placebo-controlled trial was conducted. (
  • A double-blind comparative trial. (
  • A double-blind trial found that 1,200 mg of SAMe per day for two years significantly decreased the overall death rate and the need for liver transplantation in people with alcoholic liver cirrhosis, particularly in those with less advanced liver disease. (
  • In addition to this preliminary research, many double-blind trials have shown that SAMe reduces pain, stiffness, and swelling better than placebo and equal to drugs such as ibuprofen and naproxen in people with osteoarthritis. (
  • These double-blind trials all used 1,200 mg of SAMe per day. (
  • Using Alkermes' proprietary technology for long-acting medications, the biodegradable microspheres in each dose of BYDUREON provide a controlled release of exenatide throughout the week. (
  • Register for upcoming (live) or recorded webinars, choose by topic, or search by keyword to find webinars of interest. (
  • Sign up for our newsletters and receive webinars, vitals and updates for your topic of choice. (
  • Purpose of this review is to discuss the most recent clinical evidences concerning the treatment of carotid artery stenosis, with a special focus on the endovascular treatment. (
  • The first step in the peer-review process involves delivery of the manuscript to 1 to 3 external reviewers with expertise in the paper's topic and/or field. (
  • Published material includes peer-reviewed original research, clinical trials and review articles. (
  • Our review showed that a considerable number of labels has been proposed for trial designs evaluating prognostic and predictive biomarkers which, based on patient flow elements, can be classified into five basic categories. (
  • A rapid review of the biomarker trial designs in the oncology literature suggests substantial variability in the designs, as well as in the terms proposed by authors for labeling them. (
  • Whether it's a change controller, change control board, steering committee, or project manager, a review and approval process is typically required. (
  • Applications that propose solely to write a protocol or manual of operations or to develop infrastructure for a clinical trial are not appropriate for this announcement. (
  • Two trials used intention-to-treat analysis, and all trials were analysed per protocol (excluding protocol violators). (
  • The threat of antibiotic- resistant microbes poses one of the biggest economic and health threats in our time, as microbes are becoming more resistant and fewer drugs are passing clinical trials successfully. (
  • The classification system proposed here could help clinicians and researchers in designing and interpreting trials evaluating predictive biomarkers, and could reduce confusion in labeling and reporting. (
  • Provides links to fact sheets and overviews and information on infection control, laboratory testing, and surveillance and investigation. (
  • Children with this disease need parents, teachers and other caregivers to communicate well and work as a team to prevent related long-term health problems that are caused by poor blood glucose control, Lawrence stressed. (
  • A handout on this topic is available at . (
  • In the Scotchbond Universal and Clearfil S 3 Bond Plus groups, the SBSs of surface treatment and control (distilled water) subgroups were not significantly different. (