Clinical Trials as Topic
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Clinical Trials, Phase III as Topic
Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.
Clinical Trials, Phase II as Topic
Works about studies that are usually controlled to assess the effectiveness and dosage (if appropriate) of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques. These studies are performed on several hundred volunteers, including a limited number of patients with the target disease or disorder, and last about two years. This concept includes phase II studies conducted in both the U.S. and in other countries.
Treatment Outcome
Clinical Trials, Phase I as Topic
Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.
Research Design
Controlled Clinical Trials as Topic
Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as RANDOMIZED CONTROLLED TRIALS AS TOPIC.
Double-Blind Method
Randomized Controlled Trials as Topic
Patient Selection
Multicenter Studies as Topic
Clinical Trials, Phase IV as Topic
Planned post-marketing studies of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques that have been approved for general sale. These studies are often conducted to obtain additional data about the safety and efficacy of a product. This concept includes phase IV studies conducted in both the U.S. and in other countries.
Placebos
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
Clinical Trials Data Monitoring Committees
Committees established to review interim data and efficacy outcomes in clinical trials. The findings of these committees are used in deciding whether a trial should be continued as designed, changed, or terminated. Government regulations regarding federally-funded research involving human subjects (the "Common Rule") require (45 CFR 46.111) that research ethics committees reviewing large-scale clinical trials monitor the data collected using a mechanism such as a data monitoring committee. FDA regulations (21 CFR 50.24) require that such committees be established to monitor studies conducted in emergency settings.
Neoplasms
Clinical Protocols
Prospective Studies
Evidence-Based Medicine
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
Follow-Up Studies
Single-Blind Method
Congresses as Topic
Drug Therapy, Combination
Drug Administration Schedule
Sample Size
Pilot Projects
Quality of Life
Review Literature as Topic
Published materials which provide an examination of recent or current literature. Review articles can cover a wide range of subject matter at various levels of completeness and comprehensiveness based on analyses of literature that may include research findings. The review may reflect the state of the art. It also includes reviews as a literary form.
Guidelines as Topic
A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.
Research Subjects
Biomedical Research
Questionnaires
Outcome Assessment (Health Care)
Meta-Analysis as Topic
A quantitative method of combining the results of independent studies (usually drawn from the published literature) and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness, plan new studies, etc., with application chiefly in the areas of research and medicine.
Cost-Benefit Analysis
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
Abstracting and Indexing as Topic
Severity of Illness Index
Practice Guidelines as Topic
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
Combined Modality Therapy
Antineoplastic Combined Chemotherapy Protocols
Endpoint Determination
Risk Factors
Dose-Response Relationship, Drug
Informed Consent
Textbooks as Topic
Survival Analysis
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Reproducibility of Results
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Risk Assessment
Drugs, Investigational
Placebo Effect
Patient Participation
Data Interpretation, Statistical
Prognosis
Terminology as Topic
Feasibility Studies
Dietary Supplements
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
Disease Progression
Publishing
Pain Measurement
Drug Industry
Interviews as Topic
Survival Rate
Disease-Free Survival
United States Food and Drug Administration
Drug Evaluation
Drug Approval
Stroke
A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
Cross-Over Studies
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
HIV Infections
Exercise Therapy
Random Allocation
Patient Satisfaction
Therapeutic Human Experimentation
Intention to Treat Analysis
Internet
Cognitive Therapy
A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Drug Combinations
Infusions, Intravenous
National Institutes of Health (U.S.)
Bias (Epidemiology)
Any deviation of results or inferences from the truth, or processes leading to such deviation. Bias can result from several sources: one-sided or systematic variations in measurement from the true value (systematic error); flaws in study design; deviation of inferences, interpretations, or analyses based on flawed data or data collection; etc. There is no sense of prejudice or subjectivity implied in the assessment of bias under these conditions.
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Patient Dropouts
Programmed Instruction as Topic
Data Collection
Analysis of Variance
Chronic Disease
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
National Cancer Institute (U.S.)
Pain
Research
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Antibodies, Monoclonal, Humanized
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
Drug-Related Side Effects and Adverse Reactions
Chemotherapy, Adjuvant
Drug Evaluation, Preclinical
Statistics as Topic
Predictive Value of Tests
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Treatment Failure
Pregnancy
Health Knowledge, Attitudes, Practice
Kaplan-Meier Estimate
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Age Factors
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Immunotherapy
Safety
Translational Medical Research
Decision Making
Pragmatic Clinical Trials as Topic
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Program Evaluation
Statistics, Nonparametric
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
Molecular Targeted Therapy
Neoplasm Staging
Herbals as Topic
Canada
Cardiovascular Diseases
Publication Bias
The influence of study results on the chances of publication and the tendency of investigators, reviewers, and editors to submit or accept manuscripts for publication based on the direction or strength of the study findings. Publication bias has an impact on the interpretation of clinical trials and meta-analyses. Bias can be minimized by insistence by editors on high-quality research, thorough literature reviews, acknowledgement of conflicts of interest, modification of peer review practices, etc.
Communication
Motivation
Sensitivity and Specificity
Ethics Committees, Research
Models, Statistical
Algorithms
Incidence
Genetic Therapy
Recovery of Function
Anti-HIV Agents
Databases as Topic
Ethics, Medical
Evaluation Studies as Topic
Conflict of Interest
A situation in which an individual might benefit personally from official or professional actions. It includes a conflict between a person's private interests and official responsibilities in a position of trust. The term is not restricted to government officials. The concept refers both to actual conflict of interest and the appearance or perception of conflict.
Cancer Vaccines
National Institute on Drug Abuse (U.S.)
Component of the NATIONAL INSTITUTES OF HEALTH. It supports a comprehensive research portfolio that focuses on the biological, social, behavioral and neuroscientific bases of drug abuse on the body and brain as well as its causes, prevention, and treatment. NIDA, NIAAA, and NIMH were created as coequal institutes within the Alcohol, Drug Abuse and Mental Health Administration in 1974. It was established within the NATIONAL INSTITUTES OF HEALTH in 1992.
Myocardial Infarction
Behavior Therapy
Ethics, Research
International Cooperation
Chi-Square Distribution
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
Multivariate Analysis
Proportional Hazards Models
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Quality Control
Internationality
Drug Therapy
Paclitaxel
Comparative Effectiveness Research
Conduct and synthesis of systematic research comparing interventions and strategies to prevent, diagnose, treat, and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances. (hhs.gov/recovery/programs/cer/draftdefinition.html accessed 6/12/2009)
Postoperative Complications
Health Education
Pain Management
Bookplates as Topic
Labels pasted in books to mark their ownership and sometimes to indicate their location in a library. Private bookplates are often ornate or artistic: simpler and smaller ones bearing merely the owner's name are called "book labels." They are usually pasted on the front endpaper of books. (From Harrod, The Librarians' Glossary and Reference Book, 4th rev ed & Random House Unabridged Dictionary, 2d ed)
Broadsides as Topic
Exercise
Risk Reduction Behavior
Smoking Cessation
Control Groups
Health Promotion
Databases, Factual
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Fluorouracil
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
Magnetic Resonance Imaging
MEDLINE
Neoplasm Recurrence, Local
Disease Models, Animal
Regression Analysis
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Australia
Health Care Costs
The actual costs of providing services related to the delivery of health care, including the costs of procedures, therapies, and medications. It is differentiated from HEALTH EXPENDITURES, which refers to the amount of money paid for the services, and from fees, which refers to the amount charged, regardless of cost.
Therapeutic Equipoise
Physical Therapy Modalities
Bibliometrics
Individualized Medicine
Drug Delivery Systems
Netherlands
Attitude of Health Personnel
Meta-analysis of the reversible inhibitors of monoamine oxidase type A moclobemide and brofaromine for the treatment of depression. (1/433)
The reversible inhibitors of monoamine oxidase type A (RIMAs) are a newer group of antidepressants that have had much less impact on clinical psychopharmacology than another contemporary class of medications, the selective serotonin reuptake-inhibitors (SSRIs). The RIMAs agents are distinguished from the older monoamine oxidase inhibitors (MAOIs) by their selectivity and reversibility. As a result, dietary restrictions are not required during RIMA therapy, and hypertensive crises are quite rare. In this article, we describe a series of meta-analyses of studies of the two most widely researched RIMAs, moclobemide (MOC; Aurorex) and brofaromine (BRO). Our findings confirm that both BRO and MOC are as effective as the tricyclic antidepressants, and they are better tolerated. However, BRO is not being studied at present for reasons unrelated to efficacy or side effects. MOC, which is available throughout much of the world (but not the United States), is significantly more effective than placebo and, at the least, comparable to the SSRIs in both efficacy and tolerability. For MOC, higher dosages may enhance efficacy for more severe depressions. We also found evidence that supports clinical impressions that MOC is somewhat less effective, albeit better tolerated, than older MAOIs, such as phenelzine or tranylcypromine. Little evidence has yet emerged to suggest that the RIMAs share older MAOIs' utility for treatment of depressions characterized by prominent reverse neurovegetative features. Based on available evidence, the RIMAs appear to have a limited, but useful, role in the differential therapeutics of the depressive disorders. (+info)The evolution of antibiotic therapy for neutropenic patients. (2/433)
Considerable progress has been made in the treatment of infections in neutropenic patients during the past three decades. A major contribution to this progress has been the discovery of effective new therapies and their prompt administration. Unfortunately, successful therapy of each important pathogen has resulted in the emergence of new pathogens, usually with unique patterns of antibiotic susceptibility. Unfortunately, antibiotic resistance has become an increasing threat in recent years, raising the possibility of infections that will be difficult to eradicate. Fortunately, there are new classes of antimicrobials that hold promise for therapeutic success in the future. (+info)Systematic review of day hospital care for elderly people. The Day Hospital Group. (3/433)
OBJECTIVE: To examine the effectiveness of day hospital attendance in prolonging independent living for elderly people. DESIGN: Systematic review of 12 controlled clinical trials (available by January 1997) comparing day hospital care with comprehensive care (five trials), domiciliary care (four trials), or no comprehensive care (three trials). SUBJECTS: 2867 elderly people. MAIN OUTCOME MEASURES: Death, institutionalisation, disability, global "poor outcome," and use of resources. RESULTS: Overall, there was no significant difference between day hospitals and alternative services for death, disability, or use of resources. However, compared with subjects receiving no comprehensive care, patients attending day hospitals had a lower odds of death or "poor" outcome (0.72, 95% confidence interval 0.53 to 0.99; P<0.05) and functional deterioration (0.61, 0.38 to 0.97; P<0.05). The day hospital group showed trends towards reductions in hospital bed use and placement in institutional care. Eight trials reported treatment costs, six of which reported that day hospital attendance was more expensive than other care, although only two analyses took into account cost of long term care. CONCLUSIONS: Day hospital care seems to be an effective service for elderly people who need rehabilitation but may have no clear advantage over other comprehensive care. Methodological problems limit these conclusions, and further randomised trials are justifiable. (+info)Low-molecular-weight heparin in preventing and treating DVT. (4/433)
Low-molecular-weight heparin is a relatively recent addition to the list of therapies for prophylaxis and treatment of deep venous thrombosis (DVT). As a prophylactic, low-molecular-weight heparin is as effective as standard heparin or warfarin and does not require monitoring of the activated partial thromboplastin time or the International Normalized Ratio. Traditionally, treatment for DVT required patients to be hospitalized for administration of intravenous heparin. With subcutaneous injections of low-molecular-weight heparin, treatment of DVT can be initiated or completed in the outpatient setting with no increased risk of recurrent thromboembolism or bleeding complications. Low-molecular-weight heparin is an attractive option for use in patients with a first episode of DVT, no risk factors for bleeding and the ability to administer injections with or without the help of a visiting nurse or family member. (+info)Bipolar disorder in old age. (5/433)
OBJECTIVE: To review the classification, clinical characteristics, and epidemiology of bipolar disorders in old age with a special focus on neurologic comorbidity, high mortality, and management. QUALITY OF EVIDENCE: Most available data is gleaned from retrospective chart reviews and cohort studies. Treatment recommendations are based on evidence from younger populations and a few anecdotal case reports and series involving elderly people. MAIN MESSAGE: While relatively rare in the community setting, mania in old age frequently leads to hospitalization. It is associated with late-onset neurologic disorders (especially cerebrovascular disease) involving the right hemisphere and orbitofrontal cortex. Prognosis is relatively poor; morbidity and mortality rates are high. Management of bipolarity includes cautious use of mood stabilizers, especially lithium and divalproex. CONCLUSIONS: Mania in old age should trigger a careful assessment of underlying neurologic disease, especially cerebrovascular disease. Close clinical follow up is essential. (+info)New treatments for allergic rhinitis. (6/433)
OBJECTIVE: To review new treatments for allergic rhinitis. QUALITY OF EVIDENCE: Most studies supporting the principles in this paper are double-blind, placebo-controlled trials. Good evidence supports use of antihistamines, nasal steroid sprays, and immunotherapy. Fewer trials have been done on the new antileukotrienes. MAIN MESSAGE: Allergic rhinitis causes significant morbidity, which can be successfully treated. Newer antihistamines, developed to replace terfenadine and astemizole which have potential side effects, include loratadine, cetirizine, and the newest, fexofenadine. Intranasal steroid sprays are also effective, particularly for people with nasal stuffiness. One study showed some growth retardation in children using beclomethasone over a prolonged period (1 year). The newer steroid sprays, such as fluticasone, budesonide, and mometasone furoate aqueous, however, have not been studied in the same way and are usually recommended for shorter periods. The newest group of medications showing real promise are the antileukotrienes, including zafirlukast and montelukast. Taken orally, these medications avoid the discomfort of nasal sprays and seem to have few side effects. Immunotherapy offers a new option: a short-course, preseasonal series of six to 11 injections that reduces the burden on patients for year-round therapy. Combinations of these therapies are also possible. CONCLUSIONS: With new medications and immunotherapy options, family physicians can offer effective treatment to patients with allergic rhinitis. (+info)Chaos and the transition to ventricular fibrillation: a new approach to antiarrhythmic drug evaluation. (7/433)
Sudden cardiac death resulting from ventricular fibrillation can be separated into 2 components: initiation of tachycardia and degeneration of tachycardia to fibrillation. Clinical drug studies such as CAST and SWORD demonstrated that focusing exclusively on the first component is inadequate as a therapeutic modality. The hope for developing effective pharmacological therapy rests on a comprehensive understanding of the second component, the transition from tachycardia to fibrillation. We summarize evidence that the transition from tachycardia to fibrillation is a transition to spatiotemporal chaos, with similarities to the quasiperiodic transition to chaos seen in fluid turbulence. In this scenario, chaos results from the interaction of multiple causally independent oscillatory motions. Simulations in 2-dimensional cardiac tissue suggest that the destabilizing oscillatory motions during spiral-wave reentry arise from restitution properties of action potential duration and conduction velocity. The process of spiral-wave breakup in simulated cardiac tissue predicts remarkably well the sequence by which tachycardia degenerates to fibrillation in real cardiac tissue. Modifying action potential duration and conduction velocity restitution characteristics can prevent spiral-wave breakup in simulated cardiac tissue, suggesting that drugs with similar effects in real cardiac tissue may have antifibrillatory efficacy (the Restitution Hypothesis). If valid for the real heart, the Restitution Hypothesis will support a new paradigm for antiarrhythmic drug classification, incorporating an antifibrillatory profile based on effects on cardiac restitution and the traditional antitachycardia profile (classes 1 through 4). (+info)Recurrent cystitis in nonpregnant women. (8/433)
Consistent evidence from RCTs shows that antibiotic prophylaxis (either continuous or postcoital), using trimethoprim TMP-SMZ, nitrofurantoin, or a quinolone, reduces infection rates in women with high rates of recurrent cystitis (at least two per year). Limited evidence suggests that intermittent patient-administered treatment (taken at the onset of symptoms) is an effective alternative management strategy to continuous antibiotic prophylaxis in women with high rates of infection (at least two per year). Limited evidence suggests that long-term prophylaxis is likely to benefit women with a baseline rate of more than two infections per year over many years. However, long-term treatment has not yet been evaluated in RCTs. In women who experience recurrent, uncomplicated cystitis, there is no evidence to support routine investigation of the urinary tract with excretory urography, ultrasonography, cystoscopy, or voiding cystourethrography. No specific subgroups of women who would clearly benefit from investigation have yet been adequately defined. (+info)
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Change control
From the information technology perspective for clinical trials, it has been guided by another U.S. Food and Drug ... In a good manufacturing practice regulated industry, the topic is frequently encountered by its users. Various industrial ... "Guidance for Industry - COMPUTERIZED SYSTEMS USED IN CLINICAL TRIALS". U.S. Food and Drug Administration. April 1999. Retrieved ... Taylor, J. (2008). Project Scheduling and Cost Control: Planning, Monitoring and Controlling the Baseline. J. Ross Publishing. ...
List of vaccine topics
... placebo-controlled phase 2 clinical trial". The Lancet. 381 (9871): 1037-1045. doi:10.1016/S0140-6736(12)61764-4. PMID 23352749 ... "MERS vaccine shows promise in clinical trial, say researchers". "Developing a vaccine against Nipah virus". Sifferlin, A. ( ... Adenovirus Vaccine Efficacy Trial Consortium (2013). "A phase 3, randomized, double-blind, placebo-controlled study of the ... "Inferring Reasons for the Failure of Staphylococcus aureus Vaccines in Clinical Trials". Frontiers in Cellular and Infection ...
Vitamin E
... but placebo-controlled clinical trials could not always replicate these findings. As of 2017, vitamin E continues to be a topic ... but no confirming evidence from placebo-controlled clinical trials. Antioxidant vitamins as dietary supplements have been ... In multiple clinical trials, vitamin E lowered blood concentration of the immunosuppressant medication, cyclosporine A. The US ... The authors concluded that randomized controlled trials (RCTs) are needed. A large study comparing placebo to an all rac-alpha- ...
Phytosterol
Reviewing clinical trials involving phytosterol supplementation, the FDA concluded that when consumed in the range of 1 to 3 ... A meta-analysis of 14 randomized, controlled trials comparing plant sterols to plant stanols directly at doses of 0.6 to 2.5 g/ ... Patterson, CA (July 2006). "Phytosterols and stanols: Topic 10075E" (PDF). Agriculture and Agri-Food Canada, Government of ... Plant sterols and stanols, when compared head-to-head in clinical trials, have been shown to equally reduce cholesterol levels ...
List of important publications in medicine
... clinical trials, randomized controlled trials, efficacy tests, and clinical pharmacology. The work is considered one of the ... Importance: Topic creator, Breakthrough, Impact The Canon of Medicine Author: Avicenna (Ibn Sina) Publication data: The Canon ... Bloom Bernard S.; Retbi Aurelia; Dahan Sandrine; Jonsson Egon (2000). "Evaluation Of Randomized Controlled Trials On ... 4 (2). Eldredge Jonathan D (2003). "The Randomised Controlled Trial design: unrecognized opportunities for health sciences ...
Statin
These rates, which are much higher than those seen in randomized clinical trials have been the topic of extensive debate and ... Randomized controlled trials have found these foodstuffs to reduce circulating cholesterol, but the quality of the trials has ... The author of one study argued that adverse events are more common in clinical practice than in randomized clinical trials. A ... A recent randomized controlled trial (RCT) gave statin-intolerant patients a statin or a placebo inside capsules that looked ...
Indian Council of Medical Research
In 2007 the organization established the Clinical Trials Registry - India, which is India's national registry for clinical ... fertility control, maternal and child health, control of nutritional disorders, developing alternative strategies for health ... trials. ICMR's 26 national institutes address themselves to research on specific health topics like tuberculosis, leprosy, ... "Clinical Trials Registry - India: An overview and new developments". Indian Journal of Pharmacology. 50 (4): 208. doi:10.4103/ ...
Design of experiments
... design Central composite design Clinical trial Clinical study design Computer experiment Control variable Controlling for a ... The study of the design of experiments is an important topic in metascience. A theory of statistical inference was developed by ... An experimental design or randomized clinical trial requires careful consideration of several factors before actually doing the ... To control for nuisance variables, researchers institute control checks as additional measures. Investigators should ensure ...
List of topics characterized as pseudoscience
All the randomized clinical trials of TM for the control of blood pressure published to date have important methodological ... Evaluation of the evidence from randomized controlled trials". International Journal of Clinical Practice. 63 (7): 1068-1084. ... a systematic review of clinical trials". Journal of Clinical Oncology. 24 (1): 136-140. doi:10.1200/JCO.2005.03.8406. PMC ... A systematic review of randomised clinical trials". International Journal of Clinical Practice (Systematic Review). 62 (6): 947 ...
Aletta Jacobs
... she performed a clinical trial across a mixed sampling of her clients. Finding the trial was successful, she introduced the ... control clinic in the Netherlands and the first clinic in the world devoted solely to disseminating information on the topic. ... Her pioneering birth control clinic preceded both Margaret Sanger's and Marie Stopes's clinics in the United States and England ... Both women were deeply involved in the fight for women's suffrage as well as other social issues, including birth control. She ...
The Medical Letter on Drugs and Therapeutics
... unpublished studies that are reviewed for methodological rigor with special attention to the results of clinical trials. A ... Drafts are also provided to the Food and Drug Administration and Centers for Disease Control and Prevention and to all first ... of the advisory board and 10-20 other investigators with relevant clinical or experimental experience with the article's topic ...
Medical uses of bicalutamide
... the combination of bicalutamide with a combined birth control pill was evaluated in a phase III clinical trial for the ... Turkiye Klinikleri Journal of Endocrinology-Special Topics (in Turkish). 2 (2): 110-2. ISSN 1304-0529. Moretti CG, Guccione L, ... A Double-Blind Randomized Controlled Trial". The Journal of Clinical Endocrinology and Metabolism. 103 (3): 824-838. doi: ... Birth control pills, which contain an estrogen and a progestin, are typically used for this purpose. Moreover, birth control ...
Clinical study design
Randomized controlled trial Blind trial Non-blind trial Adaptive clinical trial Platform Trials Nonrandomized trial (quasi- ... Some of the considerations here are shared under the more general topic of design of experiments but there can be others, in ... Clinical study design is the formulation of trials and experiments, as well as observational studies in medical, clinical and ... "Flu, Season, Diseases Affect Trials". Applied Clinical Trials Online. Archived from the original on 11 July 2011. Retrieved 26 ...
Microbicides for sexually transmitted diseases
"VivaGel™ - Clinical trials Under Way". Star Pharma. Archived from the original on 7 January 2008. Retrieved 1 April 2018. ... control to fight AIDS. "Research:New vaginal ring borrows from birth control to fight AIDS". Archived from the original on 2010 ... World Health Organization (2002). "HIV/AIDS Topics: Microbicides". Geneva: World Health Organization. Retrieved August 28, 2006 ... "Microbicide Clinical Trials". AVAC. Archived from the original on 16 July 2011. Retrieved 1 April 2018. Global Campaign for ...
Antibody-dependent cellular cytotoxicity
The ability of activated ex vivo NK cells has been a topic of interest for the treatment of tumors. After early clinical trials ... As NK cells are not themselves specific to certain pathways of immune control, they are utilized a majority of the time in ADCC ... The typical ADCC involves activation of NK cells by antibodies in a multi-tiered progression of immune control. A NK cell ... biological evidence and clinical perspectives". Annals of Translational Medicine. 7 (5): 105. doi:10.21037/atm.2019.01.42. ISSN ...
Parecoxib
... placebo-controlled clinical trials and a review of over 10 years of postauthorization data". Journal of Pain Research. 10: 2451 ... Current Topics in Medicinal Chemistry. 7 (3): 235-49. doi:10.2174/156802607779941323. PMID 17305567. Kiehl S (March 13, 2005 ... It is approved through much of Europe for short term perioperative pain control. It was patented in 1996 and approved for ... Parecoxib is the first parenteral COX-2 selective inhibitor available for clinical use in pain management. Its first ...
Paul Meier (statistician)
"Stratification in the design of a clinical trial", Controlled Clinical Trials, 1 (4): 355-361, doi:10.1016/0197-2456(81)90040-4 ... "Current research in statistical methodology for clinical trials", Biometrics -- Proceedings of Current Topics in Biostatistics ... "Jerome Cornfield and the methodology of clinical trials", Controlled Clinical Trials, 1 (4): 339-345, doi:10.1016/0197-2456(81) ... "Choosing covariates in the analysis of clinical trials", Controlled Clinical Trials, 10 (4): 161-175, doi:10.1016/0197-2456(89) ...
MIDAS Trial
All articles with topics of unclear notability, Articles with multiple maintenance issues, Clinical trials, Psychology ... The MIDAS Trial is a randomized controlled trial in Manchester, England using Motivational Interventions for Drugs & Alcohol ... The trial is, along with the Danish CapOpus trial, among the only trials aimed at this particular group of comorbid substance ... Articles with topics of unclear notability from February 2014, ...
Neuroprotection
Importantly, clinical trials for the drug in patients with ischemic stroke show it to be effective as well as noninvasive. ... Glutamate antagonists are a hot topic of research. Below are some of the treatments that have promising results for the future ... Glutamate antagonists are the primary treatment used to prevent or help control excitotoxicity in CNS disorders. The goal of ... Over 150 drugs have been tested in clinical trials, leading to the regulatory approval of tissue plasminogen activator in ...
Clinical data management
... and quality control procedure The case report form (CRF) is the data collection tool for the clinical trial and can be paper or ... Key topics to cover include the SOPs to be followed, the clinical data management system (CDMS) to be used, description of data ... The clinical data manager plays a key role in the setup and conduct of a clinical trial. The data collected during a clinical ... At the completion of the clinical trial, the clinical data manager ensures that all data expected to be captured has been ...
FDA Center for Devices and Radiological Health
This equivalence is used when the FDA does not think a full approval process with extensive clinical trials is necessary. The ... When the Environmental Control Administration was transformed into the Environmental Protection Agency in 1971, the Bureau of ... This study was the topic of Congressional hearings re-evaluating FDA procedures and oversight. A study by Dr. Stephanie Fox- ... The law encourages patient diversity in clinical trials submitted to the FDA for review, but does not require it. The study ...
Electrotherapy
... a systematic review and meta-analysis of randomised controlled trials". European Journal of Clinical Investigation. 44 (4): 429 ... ISBN 978-0-12-396988-0.[page needed] "Electrotherapy - an overview , ScienceDirect Topics". www.sciencedirect.com. Retrieved ... a meta-analysis of randomized controlled trials". The Journal of Bone and Joint Surgery. American Volume. 90 (11): 2322-2330. ... Cullum N, Petherick E (2008). "Pressure ulcers". BMJ Clinical Evidence. 2008. PMC 2907959. PMID 19450317. Barnes R, Shahin Y, ...
Hemicellulose
From Laboratory to Clinical Trials. Molecules, 24(7), 1251. https://doi.org/10.3390/molecules24071251 Navarrete, R. C., Himes, ... In order to control pH, sodium bicarbonate is generally added. The sodium bicarbonate inhibits the autolysis of acetyl groups ... "Sulfite Process - an overview , ScienceDirect Topics". www.sciencedirect.com. Retrieved 2022-09-08. Whistler, R. L. (1993). ... R. E., & Seheult, J. M. (2000). Applications of Xanthan Gum in Fluid-Loss Control and Related Formation Damage. SPE Permian ...
Microbicide Trials Network
The MTN's current clinical trial is the Vaginal and Oral Interventions to Control the Epidemic (VOICE) study. Cohen, Jon (28 ... Official website (Articles with topics of unclear notability from June 2019, All articles with topics of unclear notability, ... The Microbicide Trials Network (MTN) is the leading United States government-funded research organization working in the field ... Organization articles with topics of unclear notability, HIV/AIDS organizations in the United States, Medical and health ...
Clodoveo Ferri
... (born 22 March 1947) is an Italian researcher of clinical rheumatology, immunology and internal medicine. Since ... Ferri has published over 300 scientific papers in international journals that are available via PubMed on the following topics ... Serological studies and therapeutic trials on different rheumatic disorders (rheumatoid arthritis, SLE, systemic sclerosis, ... of parvovirus B19 infections was originally demonstrated in both bone marrow and skin scleroderma patients compared to controls ...
Suvorexant
Clinical trial number NCT02669030 for "A Six Week, Randomized, Double-Blind Placebo-Controlled, Suvorexant Augmentation Study ... Jacobson LH, Chen S, Mir S, Hoyer D (2016). "Orexin OX2 Receptor Antagonists as Sleep Aids". Current Topics in Behavioral ... animal studies and suicidal ideation in clinical trials). More clinical research is needed to determine the place of orexin ... A phase IV clinical trial of suvorexant as an adjunct to antidepressant therapy in people with major depressive disorder and ...
George Lewith
A randomised controlled clinical trial". Rheumatology. 50 (6): 1070-82. doi:10.1093/rheumatology/keq234. PMC 3093927. PMID ... cite journal}}: External link in ,title= (help) "CAMbrella - Communication Platform on topics related to Complementary and ... 2002) "A double-blind, randomised, controlled clinical trial of ultramolecular potencies of house dust mite in asthmatic ... A randomized, double-blind, placebo-controlled proving trial of Belladonna 30C". British Journal of Clinical Pharmacology. 56 ( ...
Jadad scale
"Assessing the quality of reports of randomized clinical trials: Is blinding necessary?". Controlled Clinical Trials. 17 (1): 1- ... A researcher conducting a systematic review for example might elect to exclude all papers on the topic with a Jadad score of 3 ... Oct 1999). "Assessing the quality of randomized trials: reliability of the Jadad scale". Controlled Clinical Trials. 20 (5): ... 2007). "The quality of reporting of randomized controlled trials of traditional Chinese medicine". Clinical Therapeutics. 29 (7 ...
Clinical trial naming conventions
... placebo-controlled multicenter trial of combination METhotrexate and intramuscular GOld therapy in rheumatoid arthritis", " ... medical or health words that are not related to the topic of the study, such as ALIVE or RESCUE; and other English words not ... CALERIE ALMANAC PARAMOUNT trial JUPITER trial ASTEROID trial PROVE-IT TIMI 22 RECOVERY trial Lowe, Derek (18 July 2019). " ... Berkwits, Michael (7 November 2000). "CAPTURE! SHOCK! EXCITE! Clinical Trial Acronyms and the "Branding" of Clinical Research ...
Process analytical technology
... at the time of conducting phase-2 clinical trials. Generally, the PAT initiative from FDA is only one topic within the broader ... The control of a steady state process when you understand the upstream & downstream effects is an easier task as common cause ... Although the FDA's PAT initiative encourages process control based on the real-time acquired data, a small part of PAT ... 2017). "In-line Raman spectroscopic monitoring and feedback control of a continuous twin-screw pharmaceutical powder blending ...
Cervical cancer
A 2019 review found no controlled trials regarding the efficacy and safety of interventions for vaginal bleeding in women with ... American Society of Clinical Oncology Resource-Stratified Clinical Practice Guideline". Journal of Global Oncology. 2 (5): 311- ... including sensitivity in discussing the topic in Aboriginal communities, embarrassment, anxiety and fear about the procedure. ... The Pap test was integrated into clinical practice in the Nordic countries in the 1960s. In Africa outcomes are often worse as ...
Benjamin Franklin
It is most useful for detailed research on specific topics. The complete text of all the documents are online and searchable; ... In doing so, the committee concluded, through blind trials that mesmerism only seemed to work when the subjects expected it, ... In his capacity as a farmer, he wrote at least one critique about the negative consequences of price controls, trade ... International Journal of Clinical and Experimental Hypnosis. 50 (4): 332-363. doi:10.1080/00207140208410109. PMID 12362951. ...
Veterans benefits for post-traumatic stress disorder in the United States
Clinical or counseling psychology interns, psychiatric residents, licensed clinical social workers, nurse practitioners, ... Some veterans' advocates recommend that veterans learn how to file claims on their own so that they retain full control over ... and Selected Topics (PDF). The CNA Corporation. p. 4. Archived (PDF) from the original on October 16, 2017. Retrieved August 23 ... A cluster-randomized trial". Journal of Traumatic Stress. 25 (6): 607-15. doi:10.1002/jts.21759. PMID 23225029. The findings of ...
Childbirth
... a Swedish randomised controlled trial". BJOG. 118 (3): 362-69. doi:10.1111/j.1471-0528.2010.02800.x. PMID 21134105. Weeks AD ( ... The prevalence of fear of childbirth around the world ranges between 4-25%, with 3-7% of pregnant women having clinical fear of ... and perinatal psychology Reproductive Health Supplies Coalition Unassisted childbirth Vernix caseosa Natural birth topics: ... a randomised controlled trial". The Australian & New Zealand Journal of Obstetrics & Gynaecology. 47 (1): 26-30. doi:10.1111/j. ...
Cornelia Ulrich
A randomized controlled trial". International Journal of Cancer. 137 (2): 471-480. doi:10.1002/ijc.29383. ISSN 1097-0215. PMID ... Key topics include the usage of inflammation inhibitors (e.g., aspirin) in cancer prevention and prognosis. to prevent cancer, ... She leads efforts to advance the impact of HCI's research in laboratory, clinical and population science, with the goal of ... controlled trial of resistance training in breast cancer patients receiving adjuvant radiotherapy: results on cancer-related ...
Goal setting
For example, Tomokazu Kishiki and colleagues performed a randomized controlled trial on surgical trainees to determine whether ... A learning goal is a generalized goal to achieve knowledge in a certain topic or field, but it can ultimately lead to better ... Journal of Social and Clinical Psychology. 34 (8): 643-673. doi:10.1521/jscp.2015.34.8.643. ISSN 0736-7236. Lens, Willy; Paixao ... There is evidence from randomised control trials that goal setting treatments improved executive function, attention/working ...
Timeline of the COVID-19 pandemic in the United Kingdom (July-December 2021)
The clinical guidelines regarding the booster vaccine are to be changed for some people, such as care home workers, to allow ... "Positive trial results for Valneva Covid vaccine". BBC News. 18 October 2021. Retrieved 20 October 2021. "Covid: Is the pace of ... Dr John Nkengasong, director of Africa's Centers for Disease Control and Prevention, warns that the UK's policy of not ... On the same topic, Scottish First Minister Nicola Sturgeon uses her Scottish National Party conference speech to urge Prime ...
Ramon Cugat
... a randomized clinical trial. Roberto Seijas, Marta Rius, Oscar Ares, Montserrat García Balletbó, Iván Serra, Ramón Cugat. Knee ... All articles with topics of unclear notability, Biography articles with topics of unclear notability, Articles with hCards, ... November 2013 Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose- ... Issues Encouraging Update on Cell Therapy in ACL Clinical Street Insider. 21 November 2014 Mesenchymal stem cells yield ...
Mitochondrial DNA
This was the first trial in the U.S. to admit canine DNA. The remains of King Richard III, who died in 1485, were identified by ... Alexeyev MF, Ledoux SP, Wilson GL (October 2004). "Mitochondrial DNA and aging". Clinical Science. 107 (4): 355-64. doi:10.1042 ... ISBN 0-12-147952-8. Syndercombe Court, Denise (24 September 2021). "Mitochondrial DNA in forensic use". Emerging Topics in Life ... citing the desirability of localised control over mitochondrial machinery. Recent analysis of a wide range of mtDNA genomes ...
John Paul Blass
... and related disorders in a relatively small placebo-controlled clinical trials and is under study in a larger multicenter trial ... Blass's interest in this topic began at NIH, where he described the first hereditary defect in a major enzyme of human ... controlled, "multicenter" clinical trial. He has written and contributed to a number of books including assorted volumes on ... He has also published on clinical aspects of Alzheimer's disease and other causes of cognitive impairment. In recent years Dr. ...
Stephen Holgate (physician)
Linked to clinical trials showing antiviral protection in asthma and COPD and the knowledge that SARS CoV-2 has developed ... completed a successful Phase II placebo-controlled trial in COVID-19 and is proceeding to undertake larger international trials ... Topic: Allergic Diseases. Co-winner: Professor Patrick G. Holt (in German) (Pages containing London Gazette template with ... While undertaking this as a Clinical Lecturer at the University of Southampton, concerned with the link between asthma death ...
Death anxiety
A meta-analysis and systematic review of randomised controlled trials". Journal of Anxiety Disorders. 59: 64-73. doi:10.1016/j. ... Another study on religions and Muslims stated that death is not a taboo topic for them. This could be another reason as to why ... Additionally, there is anxiety caused by death-recent thought-content, which might be classified within a clinical setting by a ... "Additional Lifespan Development Topics" (PDF). highered.mcgraw-hill.com. 2009. Retrieved 2019-08-04. Meyers, Karen; Golden, ...
Peter Sleight
He peer reviewed articles and co-authored scientific papers on topics such as blood pressure monitoring and control, autonomic ... He served on several data monitoring committees of major clinical trials, including Gusto, ECLA, ASCOT, ADVANCE, EUCLID, MODEST ... as chair of the ISIS group steering committee and the related coronary prevention studies coordinated by the Clinical Trials ... Peter Sleight Dept of Cardiovascular Medicine Oxford, UK, comments on the outcome of the TRANSCEND trial". Thedigitalcenter.com ...
Prokar Dasgupta
"A Single-centre Early Phase Randomised Controlled Three-arm Trial of Open, Robotic, and Laparoscopic Radical Cystectomy (CORAL ... In 1998, his paper on the topic showed that in people treated with capsaicin instillation, bladder biopsies were normal after ... Summerton, Duncan (November 2020). "Welcome from the Immediate Past-President". Journal of Clinical Urology. 13 (1_suppl): 2. ... Atala, Anthony; Slade, Debra (2012). Bladder Disease: Research Concepts and Clinical Applications. Springer Science & Business ...
Herbal medicine
Vickers AJ (2007). "Which botanicals or other unconventional anticancer agents should we take to clinical trial?". Journal of ... "WHO Quality Control Methods for Herbal Materials" (PDF). World Health Organization, Geneva, Switzerland. 2011. Archived from ... herbalism was one of 17 topics evaluated for which no clear evidence of effectiveness was found. Establishing guidelines to ... Proper double-blind clinical trials are needed to determine the safety and efficacy of each plant before medical use. Although ...
Comfort women
A 2011 clinical study found that comfort women are more prone to showing symptoms of post-traumatic stress disorder (PTSD), ... These documents were initially made public at the war crimes trial. In one of these, a lieutenant is quoted as confessing to ... In a forensic audit of the comfort women's shelter controlled by Yoon's group, it was found that barely 2.3% of its massive $ ... This led to an intense increase of public interest in the topic as well. In 1993, following multiple testimonies, the Kono ...
Lyme disease
In clinical trials involving more than 10,000 people, the vaccine was found to confer protective immunity to Lyme disease in 76 ... A randomized, double-blind, placebo-controlled trial". Annals of Internal Medicine. 138 (9): 697-704. doi:10.7326/0003-4819-138 ... "CDC - Lyme Disease - NIOSH Workplace Safety and Health Topic". www.cdc.gov. 3 August 2017. Archived from the original on 13 ... "An Efficacy, Safety, Tolerability, Immunogenicity, and Lot-Consistency Clinical Trial of a 6-Valent OspA-Based Lyme Disease ...
Frank LoVecchio
A randomized trial of protocol-based care for early septic shock ProCESS Investigators New England Journal of Medicine 2014 370 ... He was named medical director of Clinical Research at College of Health Solutions and is one of the founders of the ... In September of that year, he was part of a study that conducted a test-negative case-control investigation regarding the ... and has also worked as an on-air expert on topics including, public health, opioid crisis, and COVID-19. He was featured in ...
Writing therapy
In contrast, control participants were asked to write as objectively and factually as possible about neutral topics (e.g., a ... In a 2016 randomized controlled trial, expressive writing was tested against direction to an online support group for ... Past attempts at implementing expressive writing interventions in clinical settings indicate that there are potential benefits ... a multicenter randomized controlled trial". Supportive Care in Cancer. 29 (2): 1091-1101. doi:10.1007/s00520-020-05590-y. PMID ...
Félix Houphouët-Boigny
In order to foil any plans for a coup d'état, the president took control of the military and police, reducing their numbers ... As a result, in September 1938, his clinical director demanded that he choose between his job as a doctor and his involvement ... Between 120 and 200 secret trials were held in Yamoussoukro, in which key political figures-including Mockey and the president ... a large number of colonial topics were left in which the executive could govern by decree, and supervision over the colonial ...
Stepped-wedge trial
In medicine, a stepped-wedge trial (or SWT) is a type of randomised controlled trial (RCT). An RCT is a scientific experiment ... Hussey MA, Hughes JP (February 2007). "Design and analysis of stepped wedge cluster randomized trials". Contemporary Clinical ... In 2016, the first international conference dedicated to the topic was held at the University of York. Wang, Mei; Jin, Yanling ... Torgerson D (2015). "Stepped Wedge Randomized Controlled Trials". Trials. 16: 350. Retrieved 17 February 2017. "First ...
Chronic cerebrospinal venous insufficiency controversy
... recommend not using the proposed treatment outside clinical trials until its effectiveness is confirmed by controlled studies. ... McFarland Health Topics. ISBN 978-0-7864-8628-1. (All pages needing factual verification, Wikipedia articles needing factual ... "Health minister rejects MS therapy trial". CBC News. 2 September 2010. Weeks C (29 June 2011). "Ottawa to fund clinical trials ... The health minister accepted the CIHR recommendation and said that Canada was not going to fund clinical trials. The expert ...
Deep brain stimulation
... "pending determination of patient selection criteria and the outcome of carefully controlled clinical trials, a cautious ... Scholia has a topic profile for Deep brain stimulation. Appleby BS, Duggan PS, Regenberg A, Rabins PV (September 2007). " ... DBS has been used in a small number of clinical trials to treat people with severe treatment-resistant depression (TRD). A ... DBS has been studied in clinical trials as a potential treatment for chronic pain for various affective disorders, including ...
Vagotomy
... placebo-controlled trial". Journal of Clinical Endocrinology & Metabolism. 88 (6): 2586-92. doi:10.1210/jc.2002-030003. PMID ... ScienceDirect Topics". www.sciencedirect.com. Retrieved 2021-05-06. Surgical Treatment of Perforated Peptic Ulcer at eMedicine ... a prospective controlled trial". Annals of Surgery. 196 (3): 338-44. doi:10.1097/00000658-198209000-00013. PMC 1352612. PMID ... Williams DL, Grill HJ, Cummings DE, Kaplan JM (December 2003). "Vagotomy dissociates short- and long-term controls of ...
Gluten-free, casein-free diet
... the evidence on this topic is currently limited and weak," and noted that only a few randomized trials had been conducted on ... Current Opinion in Clinical Nutrition & Metabolic Care - Gluten-free and casein-free diets in the therapy of autism (2015) This ... Knivsberg, A.M.; Reichelt, K.L.; Høien, T.; Nødland, M. (2002). "A Randomised, Controlled Study of Dietary Intervention in ... American Academy of Pediatrics - Clinical Report (2007) In their report, the AAP did not recommend the use of special diets for ...
Prostate cancer
PARP inhibitor olaparib is an approved breast/ovarian cancer drug that is undergoing clinical trials. Also in trials for CRPC ... The Centers for Disease Control and Prevention endorsed USPSTF's conclusion. The American Society of Clinical Oncology and the ... "Gleason Score - an overview , ScienceDirect Topics". www.sciencedirect.com. Retrieved 2022-04-28. Epstein JI, Egevad L, Amin MB ... American Society of Clinical Oncology Provisional Clinical Opinion". Journal of Clinical Oncology. 30 (24): 3020-3025. doi: ...
Physiological effects in space
In a 90-day bed rest trial, a 26% ± 7 decline in the CSA of the calf muscle was observed. This rate of decline is consistent ... More recent studies on this topic clearly suggest that the type IIx MHC, which is a faster isoform than the IIa type, is more ... In such studies, plasma insulin levels have increased up to four-fold compared to those of control subjects, and blood glucose ... Clinical Science. 70 (2): 207-10. doi:10.1042/cs0700207. PMID 3956111. Berg, HE; Dudley, GA; Hather, B; Tesch, PA (July 1993 ...
Brain
... the brain and spinal cord contain extensive circuitry to control the autonomic nervous system which controls the movement of ... Several topics that might be covered here are instead covered there because much more can be said about them in a human context ... This precision is not built-in but learned by trial and error. The muscle coordination learned while riding a bicycle is an ... ISBN 978-0-7817-8383-5. Swaab, Dick F. (2003). The Human Hypothalamus - Basic and Clinical Aspects: Nuclei of the human ...
Douglas Gretzler
1974 that the trial was to be held in Santa Rosa. Shortly prior to the commencement of their trial, on June 4, Gretzler agreed ... By the early hours of October 23, Steelman had become resentful of Mestites' discussions relating to topics such as white magic ... Armstrong then climbed into the passenger seat of his Pontiac Firebird as Gretzler took control of the vehicle. Moments after ... The first to testify was clinical psychologist Dr. Irvin Roy, who outlined several Wechsler Adult Intelligence Scale tests he ...
The Goop Lab
... controlled clinical trials..." Some of the criticism regarding pseudoscience focused on Netflix. Other critics concluded that ... Topics and the series' presentation have been criticized as pseudoscientific. Prior to each episode, there is a disclaimer: " ... research studies and clinical trials have been conducted that involve LSD, psilocybin and other substances that we usually ... Some of the episodes are even helpful... the half-hour installments, which each focus on a specific wellness topic and recruit ...
Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials
Meta-analysis of randomized controlled clinical trials JAMA. 1997 May 28;277(20):1624-32. doi: 10.1001/jama.1997.03540440058033 ... Randomized Controlled Trials as Topic * Sodium / urine * Statistics as Topic Substances * Sodium ... Study selection: Thirty-three randomized controlled trials (2609 participants) in which potassium supplementation was the only ... Results: By means of a random-effects model, findings from individual trials were pooled, after results for each trial were ...
Randomized Placebo-Controlled Study of ISA247 in Plaque Psoriasis - Full Text View - ClinicalTrials.gov
Randomized Controlled Trials. Immunosuppression. Adult. Chronic Disease. Dermatologic Agents. Female. Humans. Male. Middle Aged ... MedlinePlus related topics: Psoriasis Drug Information available for: Voclosporin Genetic and Rare Diseases Information Center ... Randomized Placebo-Controlled Study of ISA247 in Plaque Psoriasis (SPIRIT). The safety and scientific validity of this study is ... Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number): Papp K, Bissonnette R, Rosoph L ...
Prophylactic colchicine therapy of intercritical gout. A placebo-controlled study of probenecid-treated patients
Pembrolizumab plus chemotherapy versus chemotherapy alone for first-line treatment of advanced oesophageal cancer (KEYNOTE-590)...
Clinical trials. Learn about our clinical trials and find available studies. *Merck Manuals. Medical information source ... placebo-controlled, phase 3 study. ... covering thousands of topics in all fields of medicine. ... Clinical trials *Clinical trials overview. *Find a trial. *Diversity in clinical trials ...
NOT-CA-22-105: Notice of Change to PAR-21-341, Exploratory Grants in Cancer Control (R21 Clinical Trial Optional)
Exploratory Grants in Cancer Control (R21 Clinical Trial Optional) NOT-CA-22-105. NCI ... Research topics may include, but are not limited to, the following:. *Identifying, assessing, and/or testing the effects of ... Notice of Change to PAR-21-341, Exploratory Grants in Cancer Control (R21 Clinical Trial Optional) ... PAR-21-341 - Exploratory Grants in Cancer Control (R21 Clinical Trial Optional) ...
Cardiac Rehabilitation | MedlinePlus
Weight Control: MedlinePlus Health Topic (National Library of Medicine) Also in Spanish ... Clinical Trials * ClinicalTrials.gov: Cardiac Rehabilitation (National Institutes of Health) Journal Articles References and ... High Blood Pressure: MedlinePlus Health Topic (National Library of Medicine) Also in Spanish ...
Oxygen-Ozone as Adjuvant Treatment in Early Control of COVID-19 Progression and Modulation of the Gut Microbial Flora - Full...
In view of these properties, a number of international clinical trials on the topic are currently ongoing. ... A multicenter randomized controlled trial for ozone autohemotherapy in the treatment of novel coronavirus pneumonia (COVID-19) ... A randomized controlled trial for the efficacy of ozonated autohemotherapy in the treatment of Novel Coronavirus Pneumonia ( ... ClinicalTrials.gov Identifier: NCT04366089. Recruitment Status : Unknown Verified April 2020 by Roberto Poscia MD, PhD, Azienda ...
Browsing 7. Regional Office for the Western Pacific by Subject
PICXEL: Perindopril/Indapamide in a Double-blind Controlled Study Versus Enalapril in Left Ventricular Hypertrophy
... does this prove that ACE inhibitor benefits extend beyond blood pressure control? ... Final Programme: Late clinical trials and medical practice (Hot Topics).. *. Dahlof B, Gosse P, Gueret O, et al, on behalf of ... seems to induce clinical benefits beyond the effects on blood pressure control. ... Help us make reference on Medscape the best clinical resource possible. Please use this form to submit your questions or ...
Reduction in COVID-19 Patients Requiring Mechanical Ventilation Following Implementation of a National COVID-19 Vaccination...
What is already known about this topic?. Clinical trials have demonstrated the efficacy of COVID-19 vaccines in a controlled ... Clinical trials have demonstrated the efficacy of COVID-19 vaccines in preventing mild and severe COVID-19 in a controlled ... However, clinical trials are not designed to assess the population impact of vaccination in a real-world setting (1,2). Israel ... Polack FP, Thomas SJ, Kitchin N, et al.; C4591001 Clinical Trial Group. Safety and efficacy of the BNT162b2 mRNA Covid-19 ...
HIV/AIDS treatment and care in Estonia: evaluation report June 2014
Observer bias Archives - The James Lind Library The James Lind Library
Clinical trials in British medicine 1858 - 1948, with special reference to the development of the randomised controlled trial. ... Topics. Essays. Records. Articles. ABOUT. What is a fair test?. About the Library. Building the Library. Using the Library. ... Why the MRC Therapeutic Trials Committee didnt introduce controlled clinical trials. JLL Bulletin: Commentaries on the history ... placebo-controlled trial. National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 ...
Stop selling higher dose Alzheimer's drug, group says - The Chart - CNN.com Blogs
In randomized, controlled clinical trials, the per-patient incidences of NCI-CTC. http://thebrooklyngame.com/forums/topic/best- ... In randomized, controlled clinical trials, the per-patient incidences of NCI-CTC Grade 3-4 neutropenia and of febrile ... In randomized, controlled clinical trials, the per-patient incidences of NCI-CTC Grade 3-4 neutropenia and of febrile ... If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. The results were ...
Stratified host-directed therapy for rifampicin-resistant TB: a randomized controlled multi-centre trial
3-armed multi-centre trial, with clinical sites in Germany, Romania, Moldova, Georgia, Mozambique, and South Africa. All ... 330 patients with RIF-R TB and baseline risk factors for poor outcome will be enrolled in a randomized, controlled, ... If successful, this groundbreaking project will increase Europes capacity to control RIF-R-TB by developing new treatments ... Both candidates are supported by data from preclinical and clinical studies. Co-primary efficacy endpoints will examine effects ...
Randomised controlled trials and retrospective controls. - Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU)
NIH VideoCast - Towards an Artificial Pancreas Public Meeting (Day 1)
State-of-the-art design of closed-loop glycemic control systems .Results of recently conducted clinical trials .Clinical Trial ... Session topics will include: • State-of-the-art design of closed-loop glycemic control systems • Results of recently conducted ... clinical trials • Clinical Trial design, including how to define success and failures of a closed-loop system • Algorithms and ... World-renowned experts will present information on key topics in the development of artificial pancreas during sessions that ...
Search | Livestrong
These include managing the side effects of cancer treatment, controlling pain, understanding clinical trials, ... The NCCS website provides comprehensive information on a wide range of cancer topics. ... Livestrong and Eli Lilly and Company Honor Clinical Trials Participants. Austin, TX - On March 10, the Livestrong Foundation ...
Peer Review at AHRQ - Study Sections | Agency for Healthcare Research and Quality
... and randomized controlled health IT related clinical trials and clinical studies. Research projects addressing emergent issues ... Other topics reviewed in this study section include technology assessment, application of information sciences, dissemination ... systematic evaluation of clinical interventions; randomized controlled trials and clinical studies; quality of life/ ... Research infrastructure applications are also reviewed in this study section and demonstrations and evaluations in topics ...
Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover...
Introduction to sample size determination and power analysis for clinical trials. Control Clin Trials 1981;2: 93-113. ... What is already known on this topic. Cannabinoids reduce hyperalgesia in animal models of neuropathic, inflammatory, and cancer ... Controlled-release oxycodone for pain in diabetic neuropathy: a randomized controlled trial. Neurology 2003;60: 927-34. ... Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial. JAMA 2003;290: ...
Topics | CMR Institute
Phase II clinical trials - traditional approaches | HSTalks
Fei Ye on Phase II clinical trials - traditional approaches, part of a collection of multimedia lectures. ... Phase II trials are often single arm but it can also be controlled with a standard treatment arm or a placebo arm. Phase II ... Topics Covered. *Frequentist methods. *Non-adaptive trial design. *Single stage single outcome design ... Other Talks in the Series: Adaptive Clinical Trial Design. Adaptive clinical trials: overview 1 Adaptive clinical trials: ...
Medical Science Monitor | A Systematic Review of the Literature Between 2009 and 2019 to Identify and Evaluate Publications on...
The inclusion criteria were publications in English from July 2009-19 (10 years); controlled clinical trials; studies with ... case-control studies, case studies, and studies that were not directly linked to the topic. ... 30 Nov 2022 : Clinical Research Retrospective Evaluation of Hematological and Clinical Factors Associated with 30-Day Mortality ... Only 1 of the studies controlled for age. This difference between the control and study groups is a confounding factor that can ...
Efficacy of pneumococcal polysaccharide vaccine in adults: Meta-analysis of controlled clinical trials of higher and lower...
Dive into the research topics of Efficacy of pneumococcal polysaccharide vaccine in adults: Meta-analysis of controlled ... T1 - Efficacy of pneumococcal polysaccharide vaccine in adults: Meta-analysis of controlled clinical trials of higher and lower ... Efficacy of pneumococcal polysaccharide vaccine in adults: Meta-analysis of controlled clinical trials of higher and lower ... Efficacy of pneumococcal polysaccharide vaccine in adults: Meta-analysis of controlled clinical trials of higher and lower ...
Results From One of the Largest Clinical Trials on Cannabinoids, Pain Treatment Published | High Times
... controlled clinical trial.. OBX CEO Dave Neundorfer released a statement about providing scientific evidence that will help ... Although there are many studies being conducted regularly on the vast topic of medical cannabis, few are conducted as a blind, ... A clinical-grade vaccine could be available in the coming months with clinical trials on humans soon. ... Home Study Results From One of the Largest Clinical Trials on Cannabinoids, Pain Treatment Published ...
Stop selling higher dose Alzheimer's drug, group says - The Chart - CNN.com Blogs
In randomized, controlled clinical trials, the per-patient incidences of NCI-CTC Grade 3-4 neutropenia and of febrile ... http://www.bucle.cl/Foro/index.php?/topic/682152-kjГёpe-apo-baclofen-no-resept-nГёdvendig/. in road a thinking and for United ... controlled+clinical+trials%2C+the+per-patient+incidences+of+NCI-CTC+Grade+3-4+neutropenia+and+of+febrile+neutropenia+were+ ... If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. The results were ...
Cover All Births And Modernize Maternity Care - Angry Bear
It has been two years since I wrote on womens healthcare and three important topics impacting women; clinical trials done ... defined by the Centers for Disease Control). However, the issue is more than providing an avenue for care. ... When I wrote on this one topic, I covered a story of a delivery that cost the life of the mother during a successful birthing ... without women participants, a failing birth control device - Essure, and maternal healthcare. The Health Affairs article is ...
The Tuberculosis Treatment Pipeline: Moving Beyond "Making the Most of What We've Got" - Treatment Action Group
AIDS Clinical Trials Group TB Transformative Science Group research priorities and agenda. Bethesda, MD: AIDS Clinical Trials ... The TB-PRACTECAL trial is a randomized, controlled, open-label, phase II/III trial. It will evaluate the safety and efficacy of ... http://www.cdc.gov/tb/topic/treatment/ltbi.htm#table1TBInfection.. *ClinicalTrials.gov [Internet]. Bethesda (MD): National ... A few other trials seek to improve MDR-TB treatment without new drugs. STREAM I, a randomized controlled trial comparing a nine ...
Week's top trending cliniEpidemiologyParticipantsRCTsEvaluatePreventionMethods2019PatientsMeta-analysesTreatmentsVaccineMedscapeResearch2018HumansOutcomeDiseasesMeshTherapeuticsPlacebo armDosageEffectivenessSystematicSubjectsStudyStudiesTherapyDesign and conductProteinBiomedicalChemotherapyProspectiveResultsDataEconomicsPotentiallyInterventionMortalitySearchIncludeDosesMedicineHealthcareEvaluationPriorityIndia
Week's top trending clini3
- The USPSTF's findings, along with news about the role of vitamins in other conditions, resulted in this week's top trending clinical topic. (medscape.com)
- Important new management guidelines and information about a potentially serious associated risk helped make Tourette syndrome this week's top trending clinical topic. (medscape.com)
- The concerted effort to provide the best, most comprehensive care for these patients has been met with much attention, as is evident by Tourette syndrome being this week's top trending clinical topic. (medscape.com)
Epidemiology5
- 1 Welch Center for Prevention, Epidemiology and Clinical Research, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Md, USA. (nih.gov)
- Journal of Clinical Epidemiology 76:65-75. (jameslindlibrary.org)
- Journal of Clinical Epidemiology 50:410-410. (jameslindlibrary.org)
- Departments of Clinical Epidemiology and Biostatistics and of Medicine (Guyatt), McMaster University, Hamilton, Ont. (cmaj.ca)
- She also has experience in infection control having spent six years at the Johns Hopkins Hospital in the Hospital Epidemiology and Infection Control Department. (cdc.gov)
Participants6
- Thirty-three randomized controlled trials (2609 participants) in which potassium supplementation was the only difference between the intervention and control conditions. (nih.gov)
- RESULTS: We included 22 trials involving 101 507 participants: 11 trials reported on presumptive pneumococcal pneumonia, 19 on all-cause pneumonia and 12 on all-cause mortality. (bris.ac.uk)
- clinical trials done without women participants, a failing birth control device - Essure, and maternal healthcare. (angrybearblog.com)
- The participants reviewed the current measures that are regularly used in clinical trials, previous controlled clinical trials and the challenges to developing effective therapeutics and diagnostics for AS going forward. (businesswire.com)
- The new findings come from the prospective Diabetes Prevention With Active Vitamin D (DPVD) trial of more than 1200 Japanese participants with impaired glucose tolerance. (medscape.com)
- The authors only considered systematic reviews and randomized controlled trials on the treatment of tics that included at least 20 participants, except for neurostimulation trials. (medscape.com)
RCTs5
- At variance to RCTs, real life trials have high generalizability, but low internal validity. (elsevier.com)
- The role of such studies is becoming a hot topic in respiratory medicine, attracting research interest and debate.In the first part of this review we discuss some of the advantages and disadvantages of different types of RCTs and analyze the strengths and weaknesses of real life trials, considering the recent examples of some studies conducted in COPD. (elsevier.com)
- Systematic review and meta-analysis, including randomised controlled trials (RCTs). (biomedcentral.com)
- Acupuncture has been shown to reduce preoperative anxiety in several previous randomized controlled trials (RCTs). (hindawi.com)
- therefore, we sought to summarize and critically assess evidence from randomized controlled trials (RCTs). (hindawi.com)
Evaluate7
- Combining single patient (N-of-1) trials to estimate population treatment effects and to evaluate individual patient responses to treatment. (jameslindlibrary.org)
- The overall objective of a phase II clinical trial is to evaluate both efficacy and safety. (hstalks.com)
- We sought to evaluate the vaccine's efficacy on clinical outcomes as well as the methodologic quality of the trials. (bris.ac.uk)
- He has written extensively on this subject, especially on choice of control group in clinical trials, evaluation and interpretation of active control trials, trials to evaluate dose-response, and trials using "enrichment" designs to help improve efficiency. (fda.gov)
- The COMS is a multicenter randomized trial investigations - sponsored by The National Eye Institute and The National Cancer Institute - designed to evaluate therapeutic interventions for patients who. (bvsalud.org)
- Objective: to synthesize the knowledge and to critically evaluate the evidences arising from randomized controlled trials on the efficacy of the complementary therapies in the management of cancer pain in adult patients with cancer in palliative care. (bvsalud.org)
- Section develops educational materials mized clinical trials to evaluate the income countries (LMICs). (who.int)
Prevention11
- Behavioral research addresses key psychosocial and behavioral targets across the cancer control continuum, from prevention to end-of-life care. (nih.gov)
- and 3.6 million high school and middle school students now use e-cigarettes, according to U.S. Centers for Disease Control and Prevention data released late last year, NBC News reported. (cnn.com)
- and Co-principal investigator of the Emory−Centers for Disease Control and Prevention HIV Clinical Trials Unit. (reachmd.com)
- I am Commander Ibad Khan and I'm representing the Clinician Outreach and Communication Activity, COCA, with the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
- Her projects focus on studies of influenza antiviral treatment and antiviral effectiveness, vaccine effectiveness, pandemic preparedness, and development of CDC clinical guidance related to treatment and prevention of seasonal and novel influenza viruses. (cdc.gov)
- Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. (cdc.gov)
- LMICs in the context of cancer control, in the number of doses for more effectiveness of cancer prevention and conducts clinical and screening trials, affordable and logistically feasible pro- early detection interventions to guide and conducts implementation and health grammes. (who.int)
- The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
- Neither the Centers for Disease Control and Prevention nor the National Prevention Information Network endorses the organizations, Website s, and materials presented. (cdc.gov)
- Randomized controlled trials, of drowning through improvements in treatment and observational studies, case series, and review articles prevention. (bvsalud.org)
- Given that infections are amenable to prevention, such estimates are key indicators for cancer control. (who.int)
Methods8
- In this lecture I will introduce some traditional methods which are based on Frequentist approach in designing a phase II clinical trial. (hstalks.com)
- METHODS: We searched several databases and all bibliographies of reviews and meta-analyses for clinical trials that compared pneumococcal polysaccharide vaccine with a control. (bris.ac.uk)
- Methods and tools for identifying, assessing, mitigating and controlling risk in business and engineering design activities. (ansi.org)
- Modern methods of contraception include oral contraceptives (such as birth control pills), contraceptive vaginal rings, condoms, intrauterine devices (also called IUDs), injectable and implantable products, and sterilization. (nih.gov)
- It is also important to discuss birth control methods with one's sexual partner. (nih.gov)
- Some forms of birth control combine methods, such as IUDs that also release hormones. (nih.gov)
- This edited book presents a variety of technologies with applications in telemedicine, originating from the fields of biomedical sensors, wireless sensor networking, computer-aided diagnosis methods, signal and image processing and analysis, automation and control, virtual and augmented reality, multivariate analysis, and data acquisition devices. (theiet.org)
- Material and Methods: 20 volunteers were included in a split-mouth controlled clinical trial. (bvsalud.org)
20191
- We performed a systematic literature search using MEDLINE (via Ovid), EMBASE (via Ovid) and the Cochrane Controlled Clinical trials register databases, published from 1 January 2000 to 31 December 2019. (biomedcentral.com)
Patients22
- This is an interventional, non-pharmacological, open, randomized, prospective, non-profit study on the adjuvant use of oxygen ozone therapy plus probiotic supplementation in the early control of disease progression in patients with COVID-19. (clinicaltrials.gov)
- 330 patients with RIF-R TB and baseline risk factors for poor outcome will be enrolled in a randomized, controlled, 3-armed multi-centre trial, with clinical sites in Germany, Romania, Moldova, Georgia, Mozambique, and South Africa. (swisstph.ch)
- 28 29 A large multicentre randomised placebo controlled study including 630 multiple sclerosis patients found an improvement in pain after 15 weeks of treatment with cannabinoids (oral δ-9-tetrahydrocannabinol or cannabis extract). (bmj.com)
- Another randomised placebo controlled single patient crossover study including 24 patients with neurogenic symptoms (18 multiple sclerosis patients) found that extract of whole plant cannabis (δ-9-tetrahydrocannabinol and cannabidiol)administered by sublingual spray improved pain. (bmj.com)
- Moreover, when a whistleblower as-serted that Pfizer had "falsified data, unblinded patients, employed inadequately trained vac-cinators, and was slow to follow up on adverse events reported in Pfizer's pivotal phase III trial," 3 rather than investigate those claims, the FDA fought in court to conceal Pfizer's pharmacovigilance reports for seventy-five years. (westonaprice.org)
- The company's spurious and criminal activities have been going on for years, including lying to get approval for malfunctioning heart valves that killed hundreds of patients worldwide, 7 conducting clinical trials on African children without their parents' consent (after which some of the children died), 8 bribing doctors, 9 suppressing research, manipulating studies, withholding information that its products caused cancer, fraudulent marketing and more. (westonaprice.org)
- Spearheaded by Dr. Jodi Cook (Agilis Vice President of Operations & Strategic Alliances) and Dr. Edwin Weeber (Chief Scientific Officer, USF Health Byrd Alzheimer's Institute, USF and a leading AS researcher), the open-forum event addressed topics important to patients, families and caregivers, such as communication and vocalization assessments, sleep and circadian rhythm measures, seizure assessments, movement and gait measures, and retrospective data analysis. (businesswire.com)
- Among the topics discussed were the differences between FUT and FUE hair transplants, updates on robotic hair transplant technology, the type of procedure most beneficial for Asian patients, criteria that determine candidacy for a hair transplant, and more. (bernsteinmedical.com)
- Read for some select quotes on a wide range of topics related to hair loss in women and treatments for female patients with androgenetic alopecia (common genetic hair loss). (bernsteinmedical.com)
- Interestingly, a recent large randomised controlled trial (RCT) assigning 2983 patients to either zero-balance or liberal strategy showed comparable disability-free survival outcome, although the zero-balance approach was associated with a higher rate of acute kidney injury [ 16 ]. (biomedcentral.com)
- In the clinical trial, there's usually a comparison between the treatment and a similar group of patients who don't get any treatment. (fda.gov)
- COMPASS Pathways has contracted with Worldwide Clinical Trials as its CRO for its first ever large-scale randomized, controlled trials, covering 400 patients with treatment-resistant depression in eight countries. (appliedclinicaltrialsonline.com)
- The trial enrolled 1063 patients, although it's not clear on how many we have data yet. (cspinet.org)
- Remdesivir-treated patients recovered after 11 days, compared to 15 days in the placebo control group. (cspinet.org)
- Additional follow-up of these patients and others in the trial on which we don't yet have outcome data could change these results in favor or against the drug. (cspinet.org)
- For years, potential therapies that attack this brain protein have failed to help patients in clinical trials. (wired.com)
- In this phase III trial, 770 patients with clinical stage I-II Hodgkin's disease (HD) have been enrolled since November 1988. (elsevier.com)
- IMSEAR at SEARO: A controlled clinical trial comparing the diuretic ethacrynic acid and furosemide in patients with congestive heart failure. (who.int)
- Works about clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. (bvsalud.org)
- When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as RANDOMIZED CONTROLLED TRIALS AS TOPIC . (bvsalud.org)
- Furthermore, survival outcomes by specific treatment type extend knowledge about the effectiveness of drug regimens among all patients, not just those eligible for clinical trials. (cdc.gov)
- Patients in both trials continued to show virologic suppression at the conclusion of each study, and no clinically relevant change from baseline in CD4+ cell counts was observed," the FDA said. (medscape.com)
Meta-analyses2
- Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses? (jameslindlibrary.org)
- BACKGROUND: Clinical trials and meta-analyses have produced conflicting results of the efficacy of unconjugated pneumococcal polysaccharide vaccine in adults. (bris.ac.uk)
Treatments3
- If successful, this groundbreaking project will increase Europe's capacity to control RIF-R-TB by developing new treatments that increase the likelihood of cure and reduce the risk of life-long disability. (swisstph.ch)
- You're intending to learn something from the trial that you're using treatments in and people have to volunteer to be in the trial. (fda.gov)
- But clinical trials can also compare two treatments, see whether one treatment is better than another in ways that you didn't necessarily anticipate. (fda.gov)
Vaccine2
- The current 23-valent vaccine was used in 8 trials. (bris.ac.uk)
- Review of safety monitoring data found that 97% of reported reactions after vaccine receipt were nonserious, consistent with preauthorization clinical trials data. (cdc.gov)
Medscape2
- Comments on Medscape are moderated and should be professional in tone and on topic. (medscape.com)
- Help us make reference on Medscape the best clinical resource possible. (medscape.com)
Research14
- The purpose of this Notice is to inform the applicant community of changes to the Scientific Research Objectives in the Funding Opportunity Announcement (FOA) PAR-21-341 - Exploratory Grants in Cancer Control (R21 Clinical Trial Optional). (nih.gov)
- Through this funding opportunity announcement (FOA), the National Cancer Institute (NCI) encourages the submission of exploratory/developmental research grant (R21) applications that focus on different aspects of cancer control by modifying behavior, screening, and understanding etiologic factors contributing to the development of cancer, and developing ways to control cancer. (nih.gov)
- The overarching goal is to provide support to promote the early and conceptual stages of research efforts on novel scientific ideas that have the potential to substantially advance population-based cancer research, such as the development of novel techniques, agents, methodologies, models, or applications that could have a major impact on a field of cancer research (e.g. epidemiologic, biomedical, behavioral, health care delivery or clinical). (nih.gov)
- Therefore, the evaluation of new resources, designed in the first instance for other pathologies but potentially active against COVID-19, represents a priority in clinical research. (clinicaltrials.gov)
- Dive into the research topics of 'Randomized controlled trials and real life studies. (elsevier.com)
- Specifically, in regard to COVID-19, Dr. del Rio has conducted research, developed policies, and written scientific publications on this topic. (reachmd.com)
- To shed some light on clinical trials, I am joined by Dr. Bob Temple, a key leader in American medicine who currently serves as Senior Advisor for Clinical Science in FDA's Center for Drug Evaluation and Research. (fda.gov)
- Basically, it's worth remembering that clinical trials are research studies. (fda.gov)
- You'll gain knowledge and hands-on experience of clinical and laboratory procedures used in diagnostics and medical research and development. (mdx.ac.uk)
- As if the fear of potentially lethal clinical trials wasn't enough to make you swear off pharmaceuticals forever try this: an association of clinical research organizations rose up in protest against a new regime of government regulations that allow regulators to reject clinical trial proposals without providing any explanation. (wired.com)
- From grappling with a never-ending list of conflicting national requirements to dealing with numerous technical issues, a research project manager at Norway's Oslo University Hospital talks about the hiccups faced by their multinational COVID-19 platform trial that was among the first studies submitted for approval under the EU Clinical Trial Regulation. (informa.com)
- Gupta Informed Consent in Clinical Research In the last five-six decades recognition of the moral right of research subjects to make their own choice or to self-determine or decide on the research. (gale.com)
- The gastric cancer research rational cancer control policies, with a economics research. (who.int)
- The mandate of the STAG includes providing advice on (i) progress towards achieving the goals of the global plan to control NTDs, (ii) challenges to the global plan to control NTDs, (iii) intersectoral activities and initiatives related to NTD control, (iv) monitoring and evaluation of control activities and (v) research and development to support the control of NTDs. (who.int)
20182
- The trial will begin in the first quarter of 2018 and is planned to include clinical sites in Czech Republic, Finland, Germany, the Netherlands, Norway, Portugal, Spain and the UK. (appliedclinicaltrialsonline.com)
- Adaptative Clinical Trials as Topic and Equivalence Trials as Topic are available for 2018. (bvsalud.org)
Humans1
- Clinical studies evaluating the analgesic action of cannabinoidsin humans are sparse. (bmj.com)
Outcome1
- [ 16 ] The timing and type of decompression procedure and selected use and optimal dosing of perioperative corticosteroids have also been widely reported but have not been validated by controlled outcome trials. (medscape.com)
Diseases7
- National Institute of Allergy and Infectious Diseases AIDS Clinical Trials Group Protocol 241 Investigators. (jameslindlibrary.org)
- Currently, she is working with Roy Anderson on modelling control and elimination strategies for neglected tropical diseases. (imperial.ac.uk)
- The most appropriate method of birth control depends on an individual's overall health, age, frequency of sexual activity, number of sexual partners, desire to have children in the future, and family history of certain diseases. (nih.gov)
- MSc Georgina Askeland at Institute of Clinical Medicine will give a trial lecture on the given topic: "The role of the microbiome in neurodegenerative diseases. (uio.no)
- Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. (cdc.gov)
- Artificial intelligence has the potential to revolutionize healthcare, yet clinical trials in neurological diseases continue to rely on subjective, semiquantitative and motivation-dependent endpoints for drug development. (cdc.gov)
- WHO, its Member States and partners give the highest priority to containing the threat of emerging and re- emerging infectious diseases, together with efforts to eradicate diseases such as dracunculiasis and poliomyelitis and controlling major neglected tropical diseases. (who.int)
Mesh1
- This Publication Type is a child to Randomized Controlled Trial in the MeSH tree hierarchy. (bvsalud.org)
Therapeutics2
- The one-day symposium, held on March 7, 2016 focused on the advent of reliable markers and clinical measures of Angelman syndrome (AS) for the development, evaluation and registration of innovative diagnostics and therapeutics. (businesswire.com)
- This course will give students a broad overview of current basic cancer biology, highlight recent advances in cancer therapeutics, and provide a clinical perspective of the pathogenesis and treatment of common cancers. (case.edu)
Placebo arm2
- Feasibility of surgical randomised controlled trials with a placebo arm: a systematic review. (jameslindlibrary.org)
- Phase II trials are often single arm but it can also be controlled with a standard treatment arm or a placebo arm. (hstalks.com)
Dosage1
- The article also discusses the recommended dosage of Rogaine, a comparison of Rogaine and Propecia, when a patient can expect to see results of medical treatment of hair loss, and other related topics. (bernsteinmedical.com)
Effectiveness3
- Rare cannabinoids are present in a variety of health and wellness products containing cannabis and hemp, but there has been virtually no clinical data on their effectiveness for any medical condition, including pain. (hightimes.com)
- We then discuss methodological approaches and options to overcome some of the limitations of real life studies.Comparing the conclusions of effectiveness and efficacy trials can provide important pieces of information. (elsevier.com)
- The evaluation of the effectiveness of HPV vaccination in LMIC settings is crucial, to understand the best implementation strategies, inform cancer control programmes, and sustain stakeholders' long-term commitment to HPV vaccination. (who.int)
Systematic3
- N of 1 trials can be aggregated to generate group mean treatment effects: A systematic review and meta-analysis. (jameslindlibrary.org)
- Empirical Evidence of Study Design Biases in Randomized Trials: Systematic Review of Meta-Epidemiological Studies. (jameslindlibrary.org)
- Use of placebo controls in the evaluation of surgery: systematic review. (jameslindlibrary.org)
Subjects4
- The HPRA acknowledges the impact of COVID-19 on the health system and broader society, and the impact it may have on clinical trials and subjects. (hpra.ie)
- Subjects enrolled in certain clinical trials may be determined as at risk groups. (hpra.ie)
- Trials involving immunosuppressant therapies may also increase the risk of COVID-19 to subjects. (hpra.ie)
- Clinical study in which a prospectively planned opportunity is included to modify trial designs and hypotheses based on analysis of data from subjects in the study. (bvsalud.org)
Study9
- Sexually active women of childbearing potential or less than 1 year post-menopausal and sexually active men who are not surgically sterile must use a reliable form of birth control during study treatment and for at least 3 months after the last dose of study drug. (clinicaltrials.gov)
- In addition to clinical examinations, electrocardiograms and blood pressure, heart rate, and laboratory assessments and M-mode echocardiographic determinations were performed for selection, at baseline, after 24 weeks, and at the end of the study (52 weeks). (medscape.com)
- Influence of reported study design characteristics on intervention effect estimates from randomized controlled trials. (jameslindlibrary.org)
- If you look at the one study, only one clinical trial reported about the 23 versus 10 milligram Aricept. (cnn.com)
- The results of a clinical study were announced on June 15 . (hightimes.com)
- Conducted by Radicle Science and Open Book Extracts (OBX), the study claims to be one of the largest cannabinoid trials to focus on pain treatment. (hightimes.com)
- These challenges could have an impact on the conduct of trials, such as the completion of study assessments, completion of study visits and the provision of IMP. (hpra.ie)
- A range of open-source models are used to project the expected impact of cervical cancer control measures and to study phenomena that cannot be investigated exclusively on the basis of empirical data. (who.int)
- The PAPRICA study is an educational intervention based on a behavioural change model among general practitioners in Lyon, France, aiming to increase knowledge and positive attitudes towards HPV vaccination ( https://clinicaltrials.gov/ct2/show/NCT03592225 ). (who.int)
Studies11
- Both candidates are supported by data from preclinical and clinical studies. (swisstph.ch)
- Although there are many studies being conducted regularly on the vast topic of medical cannabis, few are conducted as a blind, randomized, controlled clinical trial. (hightimes.com)
- Randomized controlled trials and real life studies. (elsevier.com)
- Researchers from the Harvard Medical School surveyed five clinical studies designed to measure the effects of low-level light laser therapy (LLLT) on androgenic alopecia in both men and women. (bernsteinmedical.com)
- But the results have not been peer-reviewed, the standard procedure for scientific studies, nor have they been replicated by other scientists, something typically required for a drug to be accepted into clinical practice. (cspinet.org)
- The European Medicines Agency believes that a scientific guideline on clinical trials incorporating a platform design is needed because such studies are expected to play an increasingly important role in future marketing authorization applications. (informa.com)
- In the meta-analysis data were included from RCT studies in which groups receiving preoperative acupuncture treatment were compared with control groups receiving a placebo for anxiety. (hindawi.com)
- Data monitoring in clinical trials : a case studies approach / David L. DeMets, Curt D. Furberg, Lawrence M. Friedman, editors. (who.int)
- However, despite the efficacy of tDCS, some methodological differences were found among the studies, indicating the need for well-designed and controlled studies to confirm the true potential of tDCS for ASD treatment. (bvsalud.org)
- If no relevant studies were identified, recom- hospital and emergency medical care settings, with parti- mendations were based on the panel's clinical experience cular focus on the wilderness context. (bvsalud.org)
- EPR is involved in studies of H. pylori eradication to prevent gastric cancer, most notably the HELPER trial, nested within the National Cancer Screening Program of the Republic of Korea. (who.int)
Therapy2
- [ 3 ] Goal blood pressure was 140/90 mm Hg, and no other antihypertensive therapy was given during either of the 2 arms of the trial. (medscape.com)
- Innovative trial designs are attempting to shorten treatment for drug-sensitive TB (DS-TB), and improved preventive therapy for TB, including for MDR-TB, is progressing. (treatmentactiongroup.org)
Design and conduct1
- Dr. Temple has a long-standing interest in the design and conduct of clinical trials. (fda.gov)
Protein2
- Topics include membrane structure and function, mechanisms of protein localization in cells, secretion and endocytosis, the cytoskeleton, cell adhesion, cell signaling and the regulation of cell growth. (case.edu)
- Topics include protein structure and function, DNA and chromosome structure, DNA replication, RNA transcription and its regulation, RNA processing, and protein synthesis. (case.edu)
Biomedical1
- to provide infrastructure for narrowing the gap between basic biomedical knowledge and clinical application of novel technologies, and to cross-fertilize and partner with stakeholders in order to identify and overcome the clinical and scientific challenges to the development of an artificial pancreas. (nih.gov)
Chemotherapy1
- This disease is characterized by a lack of early warning signs, diverse clinical manifestations (see Presentation), and resistance to radiation and chemotherapy. (medscape.com)
Prospective2
- [ 21 ] Lack of a prospective large-scale clinical trial perpetuates controversy as to the optimal treatment for traumatic optic neuropathy. (medscape.com)
- Prospective trials are also needed in the second step to prove the clinical benefits of the app. (bvsalud.org)
Results4
- By means of a random-effects model, findings from individual trials were pooled, after results for each trial were weighted by the inverse of its variance. (nih.gov)
- The results for all-cause mortality in double-blind trials were similar to those in all trials combined. (bris.ac.uk)
- But this week, for the first time, a ray of hope has shone through the fog of despair: preliminary results from a trial of the antiviral drug remdesivir suggest benefits in treating a disease that has already taken the lives of almost a quarter of a million people worldwide. (cspinet.org)
- At a minimum, the preliminary results could be published on NIH's own website, Clinicaltrials.gov, which is a repository of ongoing clinical trials, and submitted to a medical journal forthwith. (cspinet.org)
Data4
- Unfortunately, even with more documents in hand, we will never have any meaningful long-term safety data because, after two months, Pfizer unblinded and destroyed its control group by offering placebo recipients the injections. (westonaprice.org)
- These data were generated the old-fashioned way: by painstaking randomized, controlled trials, in this case funded by the US government. (cspinet.org)
- The topic includes the use of videoconferencing, mentorship during surgical procedures, or machine-to-machine communication to process data from one location by programmes running in another. (theiet.org)
- Suvarna In January 2015, the Institute of Medicine (IOM) [sup][1] issued a consensus, peer-reviewed, publicly available report that recommends how to promote responsible clinical trial data sharing. (gale.com)
Economics1
- These are headings are used for the general design, methodology, and economics of the trials. (bvsalud.org)
Potentially1
- Our therapies are engineered to impart sustainable clinical benefits, and potentially a functional cure, by inducing persistent expression of a therapeutic gene. (businesswire.com)
Intervention1
- In the topic Groups and therapeutic communication techniques, the intervention-IG gro. (bvsalud.org)
Mortality2
- The RR for all-cause mortality was 0.97 (95% CI 0.87-1.09), with moderate heterogeneity between trials (I(2) = 44%, p = 0.053). (bris.ac.uk)
- We conducted this trial to address the impact of restrictive vs. liberal fluid approaches on overall postoperative complications and mortality. (biomedcentral.com)
Search2
- One of the and conducts training activities for impact of Helicobacter pylori eradication principles that guide the work is the search cancer control. (who.int)
- The MEDLINE, and Google Scholar using a keyword search goal of these practice guidelines is to reduce the burden appropriate to each topic. (bvsalud.org)
Include3
- Priorities include basic behavioral and psychosocial science, interventions in cancer control areas such as tobacco use, diet, and energy balance, sun protection, and processes and effects of communication and informatics. (nih.gov)
- Topics include successfully bringing large-scale systems to completion on schedule and on budget, modeling, and cost estimating techniques, risk and variability. (ansi.org)
- Additional topics to be discussed in the course will include cell structure and function, as well as correlates to cellular and molecular pathology. (case.edu)
Doses3
- If blood pressure control was not achieved with these doses, they were gradually increased to perindopril 4 mg/indapamide 1.25 mg or enalapril 20 mg, then to perindopril 8 mg/indapamide 2.5 mg or enalapril 40 mg. (medscape.com)
- Suppose we have already established a reasonably safe targeted dose or a series of doses from phase I trials. (hstalks.com)
- Long-term follow-up shows that a single dose is as protective as two or three doses against persistent HPV16/18 infections ( https://clinicaltrials.gov/ct2/show/NCT00923702 ). (who.int)
Medicine7
- Edition, should be a useful textbook with a target audience of immunolo- lists the required and recommended for travel medicine physicians and gists, microbiologists, clinical trial vaccinations for each country. (cdc.gov)
- MD Bendik Christian Brinchmann at Institute of Clinical Medicine will give a trial lecture on the given topic: Mechanistic insight into the vascular effects of diesel exhaust particles. (uio.no)
- Cecilie Hasselø Thaulow at Institute of Clinical Medicine will give a trial lecture on the given topic: Hvordan redusere dødsfall som følge av opioidoverdoser? (uio.no)
- Nora Johansen at Institute of clinical medicine will give a trial lecture on the given topic: "The role of testosterone in menopausal hormone treatment. (uio.no)
- Liv Hesstvedt at Institute of Clinical Medicine will give a trial lecture on the given topic: The emergence of Candida auris: Challenges and opportunities for diagnostics, management and infection control. (uio.no)
- Johanne Dypvik at Institute of Clinical Medicine will give a trial lecture on the given topic: "Placenta accreta, increta, percreta. (uio.no)
- Marc Kevin McGowan at Institute of Clinical Medicine will give a trial lecture on the given topic: "Lung cancer and the immune system - Basic biology, established treatment and future potential. (uio.no)
Healthcare2
- Various challenges exist which may result in restrictions of visits to healthcare facilities, increased demands on the health service and changes to trial staff availability. (hpra.ie)
- Funding for the delivery of evidence-based clinical services to screen for cancer and precancer in underserved populations who do not have adequate access to screening, early detection interventions, and healthcare. (ruralhealthinfo.org)
Evaluation2
- The initial evaluation of the GUI identified significant usability problems that need to be addressed before the start of a clinical evaluation. (bvsalud.org)
- The goal of this project is to support the design, implementation, and evaluation of HPV-related cancer control programmes in LMICs. (who.int)
Priority2
- We will give priority review to any new clinical trial applications relating to COVID-19, and/or amendments to existing clinical trials necessary as a result of COVID-19, priority reviews can be expedited where necessary. (hpra.ie)
- The new workplan for the EU's initiative on accelerating clinical trials lays out the timelines for a set of "priority actions," such as mapping the European clinical trial environment and establishing a consolidated process for more efficiently managing scientific advice on trials. (informa.com)