Contraceptives, Postcoital: Contraceptive substances to be used after COITUS. These agents include high doses of estrogenic drugs; progesterone-receptor blockers; ANTIMETABOLITES; ALKALOIDS, and PROSTAGLANDINS.Contraceptives, Postcoital, Hormonal: Postcoital contraceptives which owe their effectiveness to hormonal preparations.Contraceptives, Oral: Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are generally estrogen or progesterone or both.Coitus: The sexual union of a male and a female, a term used for human only.Contraceptives, Oral, Combined: Fixed drug combinations administered orally for contraceptive purposes.Metrorrhagia: Abnormal uterine bleeding that is not related to MENSTRUATION, usually in females without regular MENSTRUAL CYCLE. The irregular and unpredictable bleeding usually comes from a dysfunctional ENDOMETRIUM.Contraceptive Agents: Chemical substances that prevent or reduce the probability of CONCEPTION.Menstruation-Inducing Agents: Chemical compounds that induce menstruation either through direct action on the reproductive organs or through indirect action by relieving another condition of which amenorrhea is a secondary result. (From Dorland, 27th ed)Contraceptives, Oral, Hormonal: Oral contraceptives which owe their effectiveness to hormonal preparations.Contraceptives, Postcoital, Synthetic: Postcoital contraceptives which owe their effectiveness to synthetic preparations.Contraceptive Agents, Female: Chemical substances or agents with contraceptive activity in females. Use for female contraceptive agents in general or for which there is no specific heading.Uterine Hemorrhage: Bleeding from blood vessels in the UTERUS, sometimes manifested as vaginal bleeding.Ethinyl Estradiol: A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.Contraceptives, Oral, Synthetic: Oral contraceptives which owe their effectiveness to synthetic preparations.Contraceptive Devices: Devices that diminish the likelihood of or prevent conception. (From Dorland, 28th ed)Contraception: Prevention of CONCEPTION by blocking fertility temporarily, or permanently (STERILIZATION, REPRODUCTIVE). Common means of reversible contraception include NATURAL FAMILY PLANNING METHODS; CONTRACEPTIVE AGENTS; or CONTRACEPTIVE DEVICES.Contraceptive Devices, Female: Contraceptive devices used by females.Contraception, Postcoital: Means of postcoital intervention to avoid pregnancy, such as the administration of POSTCOITAL CONTRACEPTIVES to prevent FERTILIZATION of an egg or implantation of a fertilized egg (OVUM IMPLANTATION).Contraception Behavior: Behavior patterns of those practicing CONTRACEPTION.Contraceptive Agents, Male: Chemical substances or agents with contraceptive activity in males. Use for male contraceptive agents in general or for which there is no specific heading.Intrauterine Devices: Contraceptive devices placed high in the uterine fundus.Family Planning Services: Health care programs or services designed to assist individuals in the planning of family size. Various methods of CONTRACEPTION can be used to control the number and timing of childbirths.Desogestrel: A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.Norgestrel: A synthetic progestational agent with actions similar to those of PROGESTERONE. This racemic or (+-)-form has about half the potency of the levo form (LEVONORGESTREL). Norgestrel is used as a contraceptive, ovulation inhibitor, and for the control of menstrual disorders and endometriosis.Levonorgestrel: A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Mestranol: The 3-methyl ether of ETHINYL ESTRADIOL. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL CONTRACEPTIVES.Norethindrone: A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.Vaccines, Contraceptive: Vaccines or candidate vaccines used to prevent conception.Pregnancy, Unplanned: Unintended accidental pregnancy, including pregnancy resulting from failed contraceptive measures.Sterilization, Reproductive: Procedures to block or remove all or part of the genital tract for the purpose of rendering individuals sterile, incapable of reproduction. Surgical sterilization procedures are the most commonly used. There are also sterilization procedures involving chemical or physical means.Pregnancy, Unwanted: Pregnancy, usually accidental, that is not desired by the parent or parents.Medroxyprogesterone Acetate: A synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.Spermatocidal Agents: Chemical substances that are destructive to spermatozoa used as topically administered vaginal contraceptives.Norethynodrel: A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it has usually been administered in combination with MESTRANOL.Menstruation: The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.Intrauterine Devices, Copper: Intrauterine contraceptive devices that depend on the release of metallic copper.Ethynodiol Diacetate: A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.Contraception, Immunologic: Contraceptive methods based on immunological processes and techniques, such as the use of CONTRACEPTIVE VACCINES.Abortion, Induced: Intentional removal of a fetus from the uterus by any of a number of techniques. (POPLINE, 1978)Norpregnenes: Pregnenes with one double bond or more than three double bonds which have undergone ring contractions or are lacking carbon-18 or carbon-19..Progestins: Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY.Ethinyl Estradiol-Norgestrel Combination: ETHINYL ESTRADIOL and NORGESTREL given in fixed proportions. It has proved to be an effective contraceptive (CONTRACEPTIVES, ORAL, COMBINED).Synthetic Biology: A field of biological research combining engineering in the formulation, design, and building (synthesis) of novel biological structures, functions, and systems.Contraceptives, Oral, Sequential: Drugs administered orally and sequentially for contraceptive purposes.Sterilization, Tubal: Procedures that render the female sterile by interrupting the flow in the FALLOPIAN TUBE. These procedures generally are surgical, and may also use chemicals or physical means.Genes, Synthetic: Biologically functional sequences of DNA chemically synthesized in vitro.Progesterone Congeners: Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.Androstenes: Unsaturated derivatives of the steroid androstane containing at least one double bond at any site in any of the rings.Menstrual Cycle: The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.Parity: The number of offspring a female has borne. It is contrasted with GRAVIDITY, which refers to the number of pregnancies, regardless of outcome.Intrauterine Devices, Medicated: Intrauterine devices that release contraceptive agents.Health Knowledge, Attitudes, Practice: Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).Contraceptive Devices, Male: Contraceptive devices used by males.Megestrol: 17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.Pregnancy in Adolescence: Pregnancy in human adolescent females under the age of 19.Menstruation Disturbances: Variations of menstruation which may be indicative of disease.Drug Implants: Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.Sex Education: Education which increases the knowledge of the functional, structural, and behavioral aspects of human reproduction.Medroxyprogesterone: (6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione. A synthetic progestational hormone used in veterinary practice as an estrus regulator.Estradiol Congeners: Steroidal compounds related to ESTRADIOL, the major mammalian female sex hormone. Estradiol congeners include important estradiol precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with estrogenic activities.Spermatogenesis-Blocking Agents: Chemical substances which inhibit the process of spermatozoa formation at either the first stage, in which spermatogonia develop into spermatocytes and then into spermatids, or the second stage, in which spermatids transform into spermatozoa.Ovulation Inhibition: Blocking the process leading to OVULATION. Various factors are known to inhibit ovulation, such as neuroendocrine, psychological, and pharmacological agents.Norpregnadienes: Pregnadienes which have undergone ring contractions or are lacking carbon-18 or carbon-19.Fertility: The capacity to conceive or to induce conception. It may refer to either the male or female.Condoms: A sheath that is worn over the penis during sexual behavior in order to prevent pregnancy or spread of sexually transmitted disease.Sexual Behavior: Sexual activities of humans.Transdermal Patch: A medicated adhesive patch placed on the skin to deliver a specific dose of medication into the bloodstream.Ethisterone: 17 alpha-Hydroxypregn-4-en-20-yn-3-one. A synthetic steroid hormone with progestational effects.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Estrogens: Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Nonoxynol: Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Nonoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide, formulated primarily as a component of vaginal foams and creams.Abortion Applicants: Individuals requesting induced abortions.XanthurenatesPeptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Abortion, Legal: Termination of pregnancy under conditions allowed under local laws. (POPLINE Thesaurus, 1991)Reproductive Health Services: Health care services related to human REPRODUCTION and diseases of the reproductive system. Services are provided to both sexes and usually by physicians in the medical or the surgical specialties such as REPRODUCTIVE MEDICINE; ANDROLOGY; GYNECOLOGY; OBSTETRICS; and PERINATOLOGY.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Marriage: The social institution involving legal and/or religious sanction whereby individuals are joined together.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Women's Health: The concept covering the physical and mental conditions of women.Reproductive History: An important aggregate factor in epidemiological studies of women's health. The concept usually includes the number and timing of pregnancies and their outcomes, the incidence of breast feeding, and may include age of menarche and menopause, regularity of menstruation, fertility, gynecological or obstetric problems, or contraceptive usage.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Sexually Transmitted Diseases: Diseases due to or propagated by sexual contact.Coitus Interruptus: A contraceptive method whereby coitus is purposely interrupted in order to prevent EJACULATION of SEMEN into the VAGINA.Amenorrhea: Absence of menstruation.Chlormadinone Acetate: An orally active synthetic progestational hormone used often in combinations as an oral contraceptive.Birth Rate: The number of births in a given population per year or other unit of time.Men: Human males as cultural, psychological, sociological, political, and economic entities.Postpartum Period: In females, the period that is shortly after giving birth (PARTURITION).

Antimutagenic effects of centchroman--a contraceptive and a candidate drug for breast cancer in multiple mutational assays. (1/25)

Centchroman (CC), a non-steroidal oral contraceptive and a candidate drug for breast cancer, has been reported to exhibit partial to complete remission of lesions in 40.5% of breast cancer patients. The potent anti-oestrogenic activity, negligible side-effects and anti-breast cancer activity of CC prompted us to evaluate the antimutagenic effects of this compound in a bacterial mutagenicity assay and CHO/HPRT and AS52/GPT mutation assays in vitro and in vivo in female Swiss albino mice as measured by both sister chromatid exchange (SCE) and chromosome aberrations (CA) against three known positive mutagen compounds, dimethylbenz[a]anthracene (DMBA), cyclophosphamide (CP) and mitomycin C (MMC). Antimutagenicity assays in Salmonella strains TA97a, TA100, TA98 and TA102 were carried out against commonly used known positive mutagens, sodium azide, 4-nitro-o-phenylenediamine, cumine hydroperoxide, 2-aminofluorene and danthron. A significantly reduced number of bacterial histidine revertant colonies was observed in the plates treated with 0.1, 1, 5 and 10 microg/plate CC and a positive compound when compared with bacterial plates treated with the respective positive compound alone. Ethyl methanesulfonate (EMS), a commonly used positive mutagen for CHO/HPRT and AS52/GPT gene mutation assays, was used for antimutagenicity assay in these cells. CC exhibited protective effects against the mutagenicity of EMS in these two mammalian cell mutation assays, CHO/HPRT and AS52/GPT. In the in vivo studies, pretreatment with CC reduced DMBA-induced SCE and CA and CP- and MMC-induced CA when compared with the group treated only with the positive compounds. These results indicate that CC can reduce the mutagenic effects of known genotoxic compounds.  (+info)

CDB-2914: anti-progestational/anti-glucocorticoid profile and post-coital anti-fertility activity in rats and rabbits. (2/25)

Our goal was to determine the endocrine and post-coital anti-fertility activity of CDB-2914. Concurrent administration of progesterone to rats on day 4 post-mating blocked the anti-fertility activity of a single oral 2 mg dose of CDB-2914. CDB-2914 did not exhibit progestational activity in the oestradiol-primed immature female rabbit at doses that exhibited anti-progestational activity. CDB-2914 antagonized exogenous and endogenous progesterone-stimulated uterine haptoglobin synthesis and secretion in immature and adult mated rabbits respectively. Neither CDB-2914 nor mifepristone exhibited glucocorticoid activity as determined by thymus involution in rats; mifepristone was twice as potent as CDB-2914 in antagonizing glucocorticoid action. Post-coital CDB-2914 treatment resulted in a dose-dependent reduction in implantation sites and pregnancy rates in rabbits. CDB-2914-induced inhibition of uterine weight increase, endometrial glandular arborization and uterine haptoglobin synthesis/secretion correlated with inhibition of pregnancy in mated rabbits. A single oral dose of 64 mg CDB-2914/rabbit was effective at blocking pregnancy when administered on day 4, 5, or 6 post-mating, whereas 32 mg/rabbit was only partially effective in this regard. These data demonstrate that CDB-2914 is a potent, orally active anti-progestin with weak anti-glucocorticoid activity. CDB-2914 inhibited implantation in adult rats and rabbits demonstrating its potential as a post-coital contraceptive drug.  (+info)

A single mid-follicular dose of CDB-2914, a new antiprogestin, inhibits folliculogenesis and endometrial differentiation in normally cycling women. (3/25)

Previous studies in women have shown that the antiprogestin mifepristone delays or inhibits folliculogenesis. The purpose of this study was to explore whether a new analogue, CDB-2914, has similar effects on folliculogenesis, ovulation, or on subsequent luteal phase endometrial maturation. Forty-four normally cycling, healthy women recorded urine LH and vaginal bleeding during pre-treatment, treatment, and post-treatment cycles. At a lead follicle diameter of 14-16 mm, a single oral dose (10, 50, 100 mg) of CDB-2914 or placebo was given, and daily ultrasound, oestradiol and progesterone were obtained until follicular collapse; an endometrial biopsy was obtained 5-7 days later. Single doses of CDB-2914 were well tolerated. Mid-follicular CDB-2914 suppressed lead follicle growth, causing a dose-dependent delay in folliculogenesis and suppression of plasma oestradiol. At higher doses, a new lead follicle was often recruited. Although luteinized unruptured follicles were observed at the 100 mg dose, all women had follicular collapse. There was a significant delay in endometrial maturation after CDB-2914 at all doses. The treatment cycle was lengthened by 1-2 weeks in 30% at 100, 27% at 50 and 9% at 10 mg. CDB-2914 altered ovarian and endometrial physiology without major effects on menstrual cyclicity and may have therapeutic utility.  (+info)

Circulating concentrations of the antiprogestins CDB-2914 and mifepristone in the female rhesus monkey following various routes of administration. (4/25)

The overall aim of these studies was to investigate the oral and i.m. bioavailability of CDB-2914 in intact female rhesus monkeys, and to compare the serum concentrations of CDB-2914 with that of mifepristone following oral administration. In the first study, a 50 mg bolus of CDB-2914 per monkey was administered intravenously, orally or intramuscularly. The area under the serum concentration-time curve for 72 h (AUC(0-72)) following i.v. injection was 18 320 +/- 2718 ng/ml*h, and that for oral administration was 10 464 +/- 3248 ng/ml*h. Thus, the oral bioavailability of CDB-2914 equivalents was 56%. The AUC(0-168 h) following i.m. injection was 11 226 +/- 1130 ng/ml*h. Therefore, the i.m. bioavailability of CDB-2914 equivalents was 62%. In the second study, the serum concentrations of CDB-2914 and mifepristone equivalents were compared following an oral bolus dose in two different formulations. When administered at 5 mg/kg in aqueous suspending vehicle (ASV), the mean peak serum concentration (C(max)) of CDB-2914 equivalents (192 +/- 64 ng/ml) occurred at 5 +/- 1 h, whereas the C(max) of mifepristone equivalents (82 +/- 25 ng/ml) occurred at 3 +/- 1 h. Following administration in gelatin capsules (35 mg/monkey), the C(max) of CDB-2914 equivalents (129 +/- 24 ng/ml) occurred at 5 +/- 1 h, while the C(max) of mifepristone equivalents (31 +/- 8 ng/ml) occurred at 3 +/- 1 h. The serum concentration (AUC(0-120 h)) of CDB-2914 equivalents was 4.7- or 5. 3-fold greater than that of mifepristone equivalents when administered orally in ASV or gelatin capsules respectively. The serum protein binding characteristics of CDB-2914 were also studied. CDB-2914 bound to human alpha(1)-acid glycoprotein (AAG), but not with as high an affinity as mifepristone. In contrast, neither CDB-2914 nor mifepristone bound with high affinity to AAG, corticosteroid binding globulin or sex hormone binding globulin in monkey serum. Collectively, these results indicated that CDB-2914 was more efficiently absorbed than mifepristone following oral administration to female rhesus monkeys.  (+info)

Emergency postcoital contraception. (5/25)

Emergency postcoital contraception, a method used to prevent pregnancy after unprotected sexual intercourse, is a highly effective but underutilized birth control option. Two hormone regimens, ethinyl estradiol (100 microg) with levonorgestrel (0.5 mg) or high-dose levonorgestrel (0.75 mg), given within 72 hours of intercourse and repeated 12 hours later, are available for this purpose. These regimens are packaged as Food and Drug Administration labeled, dedicated products or can be adapted for use from standard oral contraceptive pills. Emergency postcoital contraception should be considered as a primary prevention health service to women of childbearing age.  (+info)

Pharmacokinetic study of different dosing regimens of levonorgestrel for emergency contraception in healthy women. (6/25)

BACKGROUND: Levonorgestrel (LNG) is a commonly used progestin for emergency contraception; however, little is known about its pharmacokinetics and optimal dose for use. METHODS: Serum levels of LNG and sex hormone-binding globulin (SHBG) were measured in five women who received three different regimens: A: 0.75 mg LNG twice with a 12 h interval; B: 0.75 mg twice with a 24 h interval; and C: 1.50 mg in a single dose, with a washout period of 28 days between each treatment. Blood samples were taken before pill intake and at 1, 2, 4, 8 and 12 h after each dose, every 12 h up to day 4 and every 24 h until day 10. LNG and SHBG were measured in all samples. RESULTS: Maximum LNG concentrations were of approximately 27 nmol/l for treatments A and B, and close to 40 nmol/l for treatment C. The area under the curve was significantly higher for treatment C during the first 12 h, and significantly lower for treatment B during the first 24 h. After 48 h and up to 9 days from onset of treatment, serum LNG levels were similar in all three regimens. SHBG levels remained stable for 24 h, decreasing to 60% of the initial value from day 5 until day 10, with no difference between regimens. CONCLUSIONS: The similarity of LNG serum levels obtained with one single dose of 1.5 mg or two doses of 0.75 mg with a 12 h interval justify a clinical comparison of these two regimes.  (+info)

Post-coital administration of levonorgestrel does not interfere with post-fertilization events in the new-world monkey Cebus apella. (7/25)

BACKGROUND: Experimental evidence to disprove the belief that emergency contraception with levonorgestrel (LNG) prevents pregnancy by interfering with post-fertilization events is lacking. Here we determined the effect of post-coital and pre-ovulatory administration of LNG on fertility and ovulation, respectively, in the Cebus monkey. METHODS: To determine the effect on fertility, LNG 0.75 mg or vehicle were administered orally or s.c. once or twice within the first 24 h after mating occurring very close to the time of ovulation. Females that became pregnant were aborted with mifepristone and re-entered the study after a resting cycle until each of 12 females had contributed, in a randomized order, two LNG and two vehicle-treated cycles. To determine the effect on ovulation, LNG 0.75 mg or vehicle were injected twice coinciding with follicles smaller or larger than 5 mm in diameter. Six females contributed five treated cycles each. RESULTS: The pregnancy rate was identical in vehicle- and LNG-treated cycles. LNG inhibited or delayed ovulation only when treatment coincided with a follicle <5 mm diameter. CONCLUSION: In Cebus monkeys, LNG can inhibit or delay ovulation but, once fertilization has taken place, it cannot prevent the establishment of pregnancy. These findings do not support the hypothesis that emergency contraception with LNG prevents pregnancy by interfering with post-fertilization events.  (+info)

Mechanisms of action of mifepristone and levonorgestrel when used for emergency contraception. (8/25)

An emergency contraceptive method is used after coitus but before pregnancy occurs. The use of emergency contraception is largely under-utilized worldwide. One of the main barriers to widespread use is concern about the mechanism of action. Recently, treatment with either 10 mg mifepristone or 1.5 mg of levonorgestrel has emerged as the most effective hormonal method for emergency contraception with very low side-effects. However, the knowledge of the mechanism of action of mifepristone and levonorgestrel in humans, when used for contraceptive purposes and especially for emergency contraception, remains incomplete. The objective of this review is to summarize available data on the effects of mifepristone and levonorgestrel on female reproductive functions relevant to the emergency use of the compounds. When summarized, available data from studies in humans indicate that the contraceptive effects of both levonorgestrel and mifepristone, when used in single low doses for emergency contraception, involve either blockade or delay of ovulation, due to either prevention or delay of the LH surge, rather than to inhibition of implantation.  (+info)

*Fenestrel

... nonsteroidal estrogen that was developed as a postcoital contraceptive in the 1960s but was never marketed. Synthesized by ... Fenestrel (INN, USAN) (developmental code name ORF-3858) is a synthetic, ... 517-. ISBN 978-1-4757-2085-3. Revaz C, Goldenberg B, Achtari H (1971). "[Critical study of new contraceptive methods]". Schweiz ... Ortho Pharmaceutical in 1961 and studied extensively, it was coined the "morning-after-pill" or "postcoital antifertility agent ...

*Anordiol

... a postcoital contraceptive that is marketed and used in China. Relative to anordrin, anordiol has similar but more potent ... Anordiol, or anordriol, also known as 2α,17α-diethynyl-A-nor-5α-androstane-2β,17β-diol, is a synthetic steroid-like mixed ...

*Nisterime acetate

... that was developed as a postcoital contraceptive but was never marketed. It is an androgen ester - specifically, the C17α ... is a synthetic, orally active anabolic-androgenic steroid (AAS) and a derivative of dihydrotestosterone (DHT) ...

*List of MeSH codes (D16)

... contraceptives, postcoital, hormonal MeSH D27.505.696.875.360.276.310.360 --- contraceptives, postcoital, synthetic MeSH ... contraceptives, postcoital, hormonal MeSH D27.505.954.705.360.276.310.360 --- contraceptives, postcoital, synthetic MeSH ... contraceptives, oral, synthetic MeSH D27.505.696.875.360.276.310 --- contraceptives, postcoital MeSH D27.505.696.875.360.276. ... contraceptives, oral, synthetic MeSH D27.505.954.705.360.276.310 --- contraceptives, postcoital MeSH D27.505.954.705.360.276. ...

*Nisterime

The C17α acetate ester of nisterime, nisterime acetate (ORF-9326), also exists and was developed as a postcoital contraceptive ... is a synthetic anabolic-androgenic steroid (AAS) and a derivative of dihydrotestosterone (DHT) that was never marketed. ...

*Gestrinone

... has also been investigated for use as a prospective contraceptive agent and as a postcoital contraceptive. It also ... Gestrinone, sold under the brand names Dimetriose, Dimetrose, and Nemestran among others, is a synthetic steroid that is used ... is a synthetic estrane steroid and a derivative of testosterone. It is more specifically a derivative of norethisterone (17α- ...

*Emergency contraception

In May 1973, in an attempt to restrict off-label use of DES as a postcoital contraceptive to emergency situations such as rape ... p. 7. Ulipristal acetate is an orally-active synthetic selective progesterone receptor modulator which acts via high-affinity ... In February 1975, the FDA said it had not yet approved DES as a postcoital contraceptive, but would after March 8, 1975 permit ... To discourage off-label use of DES as a postcoital contraceptive, in February 1975 the FDA ordered DES 25 mg (and higher) ...

*Norgestrel

"A Multicenter Clinical Investigation Employing Ethinyl Estradiol Combined with dl-Norgestrel as Postcoital Contraceptive Agent ... is a synthetic estrane steroid and a derivative of testosterone. It is a racemic mixture of stereoisomers dextronorgestrel (the ... It has also been used as an emergency contraceptive in the Yuzpe regimen. Norgestrel, also known as rac-13-ethyl-17α-ethynyl-19 ... Norgestrel was first introduced, as a contraceptive in combination with ethinylestradiol under the brand name Ovrette in the ...

*Diethylstilbestrol

To discourage off-label use of DES as a postcoital contraceptive, the FDA in 1975 removed DES 25 mg tablets from the market and ... ISBN 978-0-470-01552-0. Dodds EC, Goldberg L, Lawson W, Robinson R (1938). "Estrogenic activity of certain synthetic compounds ... In 1973, in an attempt to restrict off-label use of DES as a postcoital contraceptive (which had become prevalent at many ... regimen of certain regular combined oral contraceptive pills superseded off-label use of DES as a postcoital contraceptive. In ...

*Clogestone acetate

... is a steroidal progestin which was investigated as a progestin-only contraceptive and postcoital contraceptive but was never ... PRACTICAL APPROACH TO THE QUANTITATIVE DETERMINATION OF SYNTHETIC PROGESTINS". The Journal of Clinical Endocrinology & ...

*Semen quality

At least three types of synthetic toxins have been found in the semen of student volunteers: polychlorinated biphenyls (PCBs), ... Depo-Provera, Adjudin, and gossypol are examples of substances used as male contraceptives or in chemical castration. Recent ... Presence of antisperm antibodies may be responsible for sperm agglutination, reduced sperm motility, abnormal postcoital test. ...
A striking feature of most bioethical discussion about patient autonomy is their exclusive focus on individual patients; this pattern mirrors medicines consistent tendency to approach illness as primarily a problem of particular patients. Similar problems are associated with each discipline. Within the medical tradition, suffering is located and addressed in the individuals who experience it rather than in the social arrangements that may be responsible for causing the problem. Instead of exploring the cultural context that tolerates and even supports practices such as war, pollution, sexual violence, and systemic unemployment - practices that contribute to much of the illness that occupies modern medicine - physicians generally respond to the symptoms troubling particular patients in isolation from the context that produces these conditions." (Sherwin pg. 75). ...
After youve recovered from post-coital bliss, whats the first thing you do? Get washed up, right? Do you clean your sex toys, too?
What, precisely, does it suggest to be human? its an age-old query, one for which theology, philosophy, technological know-how, and medication have all supplied varied solutions. yet even though a unified reaction to the query can now not be taken with no consideration, how we solution it frames the wide variety of other norms, rules, values, and intuitions that signify latest bioethical discussions. If we do not be aware of what it capacity to be human, how will we pass judgement on no matter if biomedical sciences threaten or increase our humanity?. This primary query, even if, gets little consciousness within the learn of bioethics. In a box fed on with the guarantees and perils of recent scientific discoveries, rising applied sciences, and unheard of social swap, present conversations approximately bioethics concentration totally on questions of damage and profit, sufferer autonomy, and equality of well-being care distribution. winning types of scientific ethics emphasize human capability ...
Question - Abnormal periods, unprotected intercourse. Pregnancy chances?. Ask a Doctor about Unprotected intercourse, Ask an OBGYN, Maternal and Fetal Medicine
Answer. 38. If you download a torrent from sites such as The Pirate Bay, how long will it be before your IP address has likely been logged by copyright enforcers ...
Question - Had unprotected intercourse. Red itchy rashes appeared on penis head, have mild fever. Concerned. Ask a Doctor about diagnosis, treatment and medication for Sexually transmitted disease, Ask a Psychiatrist
Generally, when you try without protection then you will most probably conceive within the first year of trying. A small portion of people conceives the second year. However, if your age is below 35years and has not conceived even after a year of unprotected intercourse then it must be the situation to take medical help.…
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Ulipristal acetate is used in the treatment of uterine fibroids.get complete information about ulipristal acetate including usage, side effects, drug interaction, expert advice along with medicines associated with ulipristal acetate at 1mg.com
Written By Johanna Ahola-Launonen. University of Helsinki. In bioethical discussion, it is often debated whether or not some studies espouse genetic determinism. A recent study by Tuomas Aivelo and Anna Uitto[1] give important insight to the matter. They studied main genetics education textbooks used in Finnish upper secondary school curricula and compared the results to other similar studies from e.g. Swedish and English textbooks. The authors found that gene models used in the textbooks are based on old "Mendelian law"-based gene models not compatible with current knowledge on gene-gene-environment-interaction. The authors also identified several types of genetic determinism, that is, weak determinism and strong determinism, which both were present in the textbooks. The somewhat intuitive remark is that genetic education has to have a strong trickle-down effect on how people understand genes, and that we should be careful not to maintain these flawed conceptions. Furthermore, it would be ...
The LNG processing plant will have a capacity of 15.5mt/y of gas and 1mt/y of condensate. It will include three LNG trains, storage and loading facilities.. Due to the extreme climatic conditions in the region, construction of the LNG project is planned to be carried out through modular methods.. Erection of the facilities for field development presents some challenges due to the permafrost conditions in the region.. Due to permafrost, the underground layer of soil stays frozen for at least two years. The layer above it freezes and thaws with change in season.. As a result, the infrastructure cannot come in contact with this soil to ensure stability. In such conditions, the infrastructure is usually erected on stilts. A liquefaction technology suitable for these conditions will be chosen for the LNG plant.. The LNG loading / unloading tankers will have a deadweight of between 183,000t and 208,000t. They will be of ice-class and be able to operate in the harsh climatic conditions of the Yamal ...
Doc, I was very intoxiated in Jakarta and met a CSW in an upscale hotel bar. Both of us had been drinking a lot, and we performed oral, and had likely had unprotected intercourse for 2 mintues befo...
Product Description Product Description Ulipristal Acetate Effective Emergency Contraception Medicine 126784-99-4 Synonym: EllaOne, Ulipristal ace CAS: 126784-99-4 M.F.: C28H35NO3 M.W.: 433.5824 Appearance: White crystalline powder Usage: contraceptive medicine anabolic powder Storage: Kept Ulipristal acetate in a cool, dry and ventilated place We guarantee good quality products. 100% refunded if parcel is not delivered or poor quality. Aanalysis List Product…
Are Levonorgestrel Side Effects Putting Your Health at Risk? | Jan 20, 2018 Check these Levonorgestrel side effect reports: A 26-year-old female patient was diagnosed with contraception, treated with LEVONORGESTREL and reported pregnancy with contraceptive device,maternal exposure during pregnancy. Dosage: .
Ulipristal acetate is a new method of treating fibroids that have moderate to severe symptoms. Its only recommended for women over 18 years of age.. The treatment involves taking one tablet orally (by mouth) once a day, with a course of treatment lasting up to three months. During this time you shouldnt bleed and your fibroids will shrink.. After the initial course of treatment, you wait to see what your first two periods are like while not taking treatment. If theyre still heavy, another three month course of ulipristal acetate may be recommended.. Treatment should only be started when menstruation (monthly periods) have occurred. The first course of treatment should start during the first week of menstruation. Your doctor will be able to explain how long the intervals between treatment courses should be.. If youre taking a course of ulipristal acetate and you miss a dose, you should take a dose as soon as possible. However, if the dose was missed by more than 12 hours, you shouldnt take ...
Summer is like the post-coital feeling - not everyone takes to it after the lovely splash of spring and the bygone chilly days. Though the post-coital session evokes warmth and a sense of fulfilment, it cannot compare to coitus itself. Period. The sweat and the addendum to it makes it a tad difficult for me but then there are some bright spots (literally and metaphorically) to summer. The appearance of water/musk melons, pepsi-colas and other summery delights alleviate the problem of post-spring/winter melancholia partially. Summer also signals the end of the semester and examination blues. I thought after becoming a teacher, I would be free from the end-of-term low tide but looks like the end always comes with a sting of boredom, a sense of forlornness and loneliness of having to bid adieu to a set of students with whom the year was spend in wanton abandon, endless gossip, conniving moments and of course some lessons. I will miss them and that feeling makes me a bit morose ...
Professional guide for Levonorgestrel (Systemic). Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more.
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The H2 2018 Global Capacity and Capital Expenditure Outlook for LNG Regasification Terminals - Asia to Dominate LNG Regasification Capex and Capacity Additions report has been added to ResearchAndMarkets.coms offering.
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DOCTYPE html, ,html, ,head, ,meta name=viewport content=initial-scale=1.0, user-scalable=no, ,meta charset=utf-8, ,title,Polygon with Hole,/title, ,style, /* Always set the map height explicitly to define the size of the div * element that contains the map. */ #map { height: 100%; } /* Optional: Makes the sample page fill the window. */ html, body { height: 100%; margin: 0; padding: 0; } ,/style, ,/head, ,body, ,div id=map,,/div, ,script, // This example creates a triangular polygon with a hole in it. function initMap() { var map = new google.maps.Map(document.getElementById(map), { zoom: 5, center: {lat: 24.886, lng: -70.268}, }); // Define the LatLng coordinates for the polygons outer path. var outerCoords = [ {lat: 25.774, lng: -80.190}, {lat: 18.466, lng: -66.118}, {lat: 32.321, lng: -64.757} ]; // Define the LatLng coordinates for the polygons inner path. // Note that the points forming the inner path are wound in the // opposite direction to those in the outer path, to form the ...
Help please! Firsy day of my last period was on 10/3. I had unprotected contact on 10/5. It happened again on 10/15, and on 10/16, i took Glanique 1 (levonorgestrel 1.5mg). Five days passed and I .... ...
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A new letter has been published on the Central Alerting System website relating to Esmya (ulipristal acetate) for uterine fibroids to be actioned within 48 hours. The letter highlights new temporary safety measures which have been introduced for Esmya following reports of serious liver injury in women using the medicine for uterine fibroids in adult...
Apical surfaces of human endometrial epithelium and endothelium are key elements for the initiation of molecular interactions to capture the blastocyst or leukocyte, respectively. The L-selectin adhesion system has been strongly proposed to play an important role in the initial steps of trophoblast adhesion and promotion of integrin-dependent processes, ultimately culminating in the establishment of the embryo-maternal interface. On the basis of these facts, we hypothesized a novel role for pinopodes as the first embryo-fetal contact sites to contain the highest subcellular expression of L-selectin ligand suggesting its role in early adhesion as predicted. Thus, the objective of this study was therefore to determine the subcellular pattern of distribution of the L-selectin ligand (MECA-79) in human endometrial apical membrane region during the window of implantation. Endometrial biopsies of secretory phases from fertile females ranging in age between 25 and 42years were studied using several approaches,
Apical surfaces of human endometrial epithelium and endothelium are key elements for the initiation of molecular interactions to capture the blastocyst or leukocyte, respectively. The L-selectin adhesion system has been strongly proposed to play an important role in the initial steps of trophoblast adhesion and promotion of integrin-dependent processes, ultimately culminating in the establishment of the embryo-maternal interface. On the basis of these facts, we hypothesized a novel role for pinopodes as the first embryo-fetal contact sites to contain the highest subcellular expression of L-selectin ligand suggesting its role in early adhesion as predicted. Thus, the objective of this study was therefore to determine the subcellular pattern of distribution of the L-selectin ligand (MECA-79) in human endometrial apical membrane region during the window of implantation. Endometrial biopsies of secretory phases from fertile females ranging in age between 25 and 42years were studied using several approaches,
There are 2 types of emergency contraception which can be taken up to 5 days after unprotected sex. Order online with free next day delivery.
The morning after pill, emergency contraception cost (price) and effectiveness at the Mobile Center. Trusted health care for nearly 100 years by Planned Parenthood.
The morning after pill, emergency contraception cost (price) and effectiveness at the Youngstown Health Center. Trusted health care for nearly 100 years by Planned Parenthood.
I have found that while people are pretty interested in the topic of emergency contraception, theres not a lot of understanding about how it does (or doesnt work). In fact, I continue to be surprised at how many SANE/SAFE trainings out there dont really cover much about EC beyond the type of meds and doses…
Doctors give trusted answers on uses, effects, side-effects, and cautions: Dr. Nwanguma on emergency contraception protect sexually: The two are not related.
Levonorgestrel yog ib yam tshuaj hormone uas siv los ua ntau hom tshuaj tiv thaiv menyuam yaus. Hauv daim ntawv tshuaj, muag raws li lub hom phiaj Hom B ntawm lwm tus neeg, nws tseem pab tau li ntawm 120 teev thaum muaj xwm ceev yug menyuam. Nws yuav tsis ua hauj lwm ntev tom qab sib deev thiab tsuas ua haujlwm ua ntej cev xeeb tub tau tshwm sim. Nws tseem ua ke nrog ib qho tshuaj no ua ke nrog kev siv tshuaj tiv thaiv kab mob hauv lub cev. Hauv ib qho IUD, muag raws li Mirena ntawm lwm tus neeg, nws yog qhov zoo rau kev tiv thaiv ntev ntawm kev xeeb tub.Ua daim ntawv implantable levonorgestrel kuj muaj nyob hauv qee lub tebchaws.
Contact patients currently taking Esmya for uterine fibroids as soon as possible and advise them to stop their treatment. The licence for Esmya has been suspended to protect public health while a safety review is conducted following a further case of liver injury requiring transplant.
Planned LNG Terminals Market - Global Analysis, Competitive Landscape and Capacity Forecasts to 2017 is the latest report that analyses the planned LNG terminals market with the competitive landscape and capacity forecasts to 2017. The report provides information about the planned LNG liquefaction and regasification markets during 2012-2017. The report gives a detailed information on the planned LNG terminals that will commence operations globally by 2017, the major countries accounting for the LNG capacity additions and the dominating companies in the liquefaction and regasification capacity additions.. The report also provides key issues and challenges for the industry in the current industry environment ...
1 Answer - Posted in: plan b, nightmares, emergency contraception - Answer: It doesnt surprise me. That is a large dose of hormones and it shocks ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. LNG Market Report discusses about development policies and plans as well as manufacturing processes and cost structures. It also states import/export consumption, supply and demand figures, cost, price, revenue and gross margins. Various definitions, classification, applications of industry and chain structure are also given.. The report elaborates LNG Market overview with various definitions and classification of the industry, applications of industry and chain structure. Present day status of the LNG Market in key regions is stated and industry policies and news are analysed.. Next part of the LNG Market analysis report speaks about the manufacturing process. The process is analysed thoroughly with respect three points, viz. raw material and equipment suppliers, various manufacturing associated costs (material cost, labour cost, etc.) and the actual process ...
In May, Shell revealed it has been in talks with Anadarko about acquiring a stake in its Mozambique fields, but had pulled back because the asking price was too high. Mr. Guebuza said Thursday that he wants Mozambiques first LNG exports to start shipping in 2018, an ambitious deadline in a country that has no established oil and gas industry and limited infrastructure. Shells floating LNG vessels produce, liquefy and transfer gas to tankers for export, removing the need for a costly and complex onshore terminal. The technology is being used on a project in Australia with a similar five-year development schedule and could be one solution for Mozambique, said Mr. Steenson. Shell took the decision to deploy a $10 billion floating LNG vessel on Australias Prelude field in 2011 and it is due to start operating late in 2016 or early in 2017, said Mr. Steenson. The Prelude vessel, the first of its kind in the world, will produce around 5.3 million tpy of LNG and condensate, he said. At present, the ...
Hi there I had an unprotected sex with my bf and get postinor 1 before 24 hours. But after getting that (after 3 hours) again we had sex.
The most common form of emergency contraception consists of oestrogen and progestagen while the other consists of progestagen-only...
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OTC emergency contraceptive (EC) use is both an ethically and therapeutically charged issue. Ethically, controversy arises over product mechanism of action (MOA) and, therapeutically, around unintended use as routine contraception. In order to help facilitate understanding, pharmacists can review the trials evaluating drug MOA, along with the risks, contraindications, counseling points, and public health implications of emergency contraception.. History and Proposed MOA. Hormonal post-coital contraception was first introduced in the late 1970s by Yuzpe and Lance, who suggested use of 0.1 mg ethinyl estradiol/0.5 mg levonorgestrel within 72 hours of intercourse followed by repeat dosing 12 hours later.1 This was standard post-coital contraception until introduction of the levonorgestrel only method.1 Currently, 1.5 mg levonorgestrel once, or two 0.75 mg levonorgestrel doses separated by 12 hours, have emerged as gold standards- with the former preferred over the latter.. Current research is ...
TY - JOUR. T1 - Pharmacokinetic study to compare the absorption and tolerability of two doses of levonorgestrel following single vaginal administration of levonorgestrel in Carraguard® gel. T2 - a new formulation for "dual protection" contraception. AU - Sitruk-Ware, Regine. AU - Brache, Vivian. AU - Maguire, Robin. AU - Croxatto, Horacio. AU - Kumar, Narender. AU - Kumar, Sushma. AU - Montero, Juan Carlos. AU - Salvatierra, Ana Maria. AU - Phillips, David. AU - Faundes, Anibal. PY - 2007/6/1. Y1 - 2007/6/1. N2 - Objective: The study was conducted to assess levonorgestrel (LNG) serum levels achieved after a single administration of two different doses of Carraguard vaginal gel containing LNG (CARRA/LNG), designed for use as microbicide and contraceptive for potential dual protection. Materials and Methods: This was a randomized double-blind pharmacokinetic study conducted in 12 subjects enrolled at two centers. Each subject received a single vaginal administration of CARRA/LNG containing either ...
Allergans New Drug Application for the approval of ulipristal acetate to treat abnormal bleeding due to uterine fibroids has been accepted by the FDA.
ABSTRACT: Emergency contraception refers to contraceptive methods used to prevent pregnancy in the first few days after unprotected intercourse, sexual assault, or contraceptive failure. Although the U.S. Food and Drug Administration approved the first dedicated product for emergency contraception in 1998, numerous barriers to emergency contraception remain. The purpose of this Committee Opinion is to examine barriers to the use of emergency contraception, emphasize the importance of increasing access, and review new methods of emergency contraception and limitations in efficacy in special po... ...
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This is a pilot randomized controlled trial to assess the effects of advanced supply of emergency contraception versus routine care in a teen postpartum population. The goals are to assess feasibility of recruiting and retaining postpartum teens; to obtain estimates of the prevalence of (use of Plan B, primary contraceptive continuation, unprotected intercourse exposure, and pregnancy rates), in postpartum teens given advanced supply of Plan B; to assess whether or not (lack of use of Plan B, contraceptive method non-continuation, and unprotected intercourse exposure), are surrogate markers for risk of unintended pregnancy ...
About 1 in 5 pharmacies incorrectly denies teen girls access to emergency contraception (EC), or the morning after pill, according to a new study. Posing as either 17-year-old girls or doctors seeking Plan B emergency contraception for their 17-year-old patients, researchers from Boston Univers...
Ulipristal is a prescription-only emergency contraceptive. It is at least as effective as levonorgestrel when administered within 72 hours of unprotected sexual intercourse, and is more effective than levonorgestrel in the 72- to 120-hour window.
This eMedTV resource provides more details on emergency contraception and the abortion pill, including how many doctor visits are required when using mifepristone. Instructions are also given on what to do if you have any questions.
We get a lot of questions from teens who are wondering if they can prevent pregnancy after intercourse, whether the concern is due to a broken condom or from not using any method of contraception in the first place. Regardless of how it happened, there is something that can reduce the risk of pregnancy if used within 120 hours (or with an IUD, eight days) of your risk. That something is Emergency Contraception.
Call (585) 279-4890 to get the Plan B or morning after pill emergency contraception, and other affordable and confidential birth control services for teens and adults. Walk-ins are welcome. Free bus passes are available.
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Under the terms of the contract, KBR will provide feasible conceptual solutions for SLNGs consideration and create a design option that could be scalable in the long run, it said in a statement.. This work is expected to be performed over five months, with KBR performing the feasibility study through a team comprising KBRs London and Singapore offices, its Granherne subsidiary and the SLNGs development team.. Greg Conlon, KBR president, Asia Pacific said the project aims to facilitate the growth of the energy market and the LNG hub in Singapore.. The Singapore LNG terminal currently has three 188,000-cbm storage tanks and an LNG jetty capable of receiving liquefied natural gas carriers with the capacity of 120,000-cbm to 265,000-cbm.. SLNG has also recently signed a memorandum of understanding with Maritime and Port Authority of Singapore for the development of an LNG truck loading facility at the terminal. The truck loading facility will be used to service LNG bunkering, and a variety of ...
Samsung Heavy Industries added another 462.3 billion won ($409.38 million) to their backlog today with the order of a pair of LNG carriers for a Joint Venture company owned by Marubeni Corporation and SK Shipping Co., Ltd.. Upon delivery in January and October 2017 respectively, both ships will be placed on 30-year charter contracts with a UK subsidiary of the French oil major, Total S.A. With a loading capacity of 180,000 m3, the ships will be the largest LNG carriers which are enabled to pass the Panama Canal after the planned expansion in 2015.. Each of the two ships will be engaged in the transportation of LNG from the separate projects: the Australian Ichthys LNG project in which some other Japanese corporations participate, and the Sabine Pass Liquefaction Project where the American shale-gas will be transformed into LNG for the first time.. ...
that depends. plan b one-step and generic levonorgestrel work best if you take them within 3 days after sex, but they may work up to 5 days after sex.
Levonorgestrel is a hormone used to prevent pregnancy. It is taken just after the intercourse, if no contraceptive methods were used during it, or the used method was not reliable.
Levonorgestrel is a hormone used to prevent pregnancy. It is taken just after the intercourse, if no contraceptive methods were used during it, or the used method was not reliable.
The evaluation of the effectiveness of an intrauterine-administered progestogen (levonorgestrel) in the symptomatic treatment of endometriosis and in the staging of the ...
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People have been buzzing since the latest FDA decision to allow 17 year old teenagers access to Plan B, also known as the morning after pill. Some are thrilled, some are appalled.
EContra One-Step® is one tablet with levonorgestrel, a hormone that has been used in many birth control pills for several decades. EContra One-Step® contains a higher dose of levonorgestrel than birth control pills, but works in a similar way to prevent pregnancy. It works mainly by stopping the release of an egg from the ovary. It is possible that EContra One-Step®may also work by preventing fertilization of an egg (the uniting of sperm with the egg) or by preventing attachment (implantation) to the uterus (womb ...
Buy Mifepristone (RU486) (CAS 84371-65-3), a PR and GR antagonist. Join researchers using high quality Mifepristone (RU486) from Abcam and achieve your…
Methanol Or Lng? - posted in Overall View: Hi,I can see a lot of experts here. I have a general question to ask. To make use of a natural gas resource, should a owner build a methanol plant or a LNG terminal?Chemically both options are possible. You can use methanol synthesis to make methanol from CH4 and water and sell CH3OH as a commodity. Or, use compression technology to liquify the natural gas and ship it to where its needed, for example US. But my sense is that LNG plant is pret...
Samsung Heavy Industries has been selected as a technical partner in building an icebreaking LNG carrier for the Russias Arctic LNG2 Project. As a result, Samsung Heavy Industries has secured a big advantage in landing an order for 15 polar icebreaking LNG carriers that Russia is expected to build
INL has developed a LNG/CNG refueling process and method for dispensing liquefied natural gas (LNG), compressed natural gas (CNG) or both on demand. The process utilizes CNG as a source of LNG, and is stored in a cryogenic storage vessel on site. A low volume high pressure pump is coupled to the source of LNG to produce a stream of pressurized LNG that can be selectively directed through a LNG or CNG flow path, which may include a vaporizer to produce CNG from the pressurized LNG. The... read more ...
BC targets LNG tax ruling The British Columbia government has set Nov. 30 as its deadline to finalize all provincial LNG costs, including taxes, along with the costs of meeting environmental standards and the terms of First Nations compensation. Premier Christy Clark made the pledge May 5 in Kuala L...
This eMedTV page explains when side effects of mifepristone could be potentially serious and require immediate medical treatment. This article also describes the results of extensive clinical trials that have shown how often reactions to this drug occur.
OnlineClinic.co.uk offers the answers for morning-after-pill frequently asked questions so you can make the informed decision about emergency contraception.
By Proov inventor and Ph.D. scientist, Amy Beckley Typically women struggling to conceive need to be actively trying for 12 months before they can seek help from a doctor--but why? This is because most fertile couples will conceive within a year of having unprotected intercourse. However, if you have irregular periods,
PG Flow Solutions has been awarded a contract to deliver a large seawater circulation pump system to the worlds first LNG driven wellboat
im a female 21 years old and i had unprotected sex about week ago, on that night i took the drug Levonorgestrel , after few days i didnt have a regular bleeding after taking a pill ,now im waiting fo...
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Women can use emergency contraception to prevent pregnancy after known or suspected failure of birth control or after unprotected intercourse. Many patients do not ask for emergency contraception because they do not know of its availability. Emergency contraception has been an off-label use of oral contraceptive pills since the 1960s. Dedicated products, the Yuzpe regimen (Preven) and levonorgestrel (Plan B), were marketed in the United States after 1998 but had been available in Europe for years before that. A third approved method of emergency contraception is the insertion of an intrauterine device. Emergency contraception is about 75 to 85 percent effective. It is most effective when initiated within 72 hours after unprotected intercourse. The mechanism of action may vary, depending on the day of the menstrual cycle on which treatment is started. Despite the large number of women who have received emergency contraception, there have been no reports of major adverse outcomes. If a woman becomes
A campaign to increase knowledge about emergency contraception has been identified as one of the relatively few interventions with the potential to reduce the incidence of unwanted pregnancy. This study relates variations in use of emergency contraception to population characteristics and identifies indicators which may be used to measure the impact of a campaign. The study is a secondary analysis of routinely collected data and health service indicators. Prescription data is used to compare districts and examine the population based factors which are associated with use of emergency contraception and termination of pregnancy. A stepwise multiple regression includes termination of pregnancy rates as the dependent variable. Uptake of prescriptions for emergency contraception and termination of pregnancy rates within FHSAs show a positive correlation (0.56). High use of both services is present in inner London FHSAs. A low termination rate combined with high emergency contraceptive use is typical of West
Emergency contraceptives are methods of preventing pregnancy after unprotected sexual intercourse (usually up to 72 hours after). They do not protect against sexually transmitted infections. Emergency contraception is not abortion, although some people who object to abortion also object to emergency contraception.
When should I talk to a doctor or pharmacist? Ask a doctor or pharmacist before use if you are taking efavirenz (HIV medication) or rifampin (tuberculosis treatment) or medication for seizures (epilepsy). These medications may reduce the effectiveness of AfterPill and increase your chance of becoming pregnant. Your doctor may prescribe another form of emergency contraception that may not be affected by these medications.. How does AfterPill work? AfterPill is one tablet with levonorgestrel, a hormone that has been used in many birth control pills for several decades. AfterPill contains a higher dose of levonorgestrel than birth control pills, but works in a similar way to prevent pregnancy. It works mainly by stopping the release of an egg from the ovary. It is possible that AfterPill may also work by preventing fertilization of an egg (the uniting of sperm with the egg) or by preventing attachment (implantation) to the uterus (womb).. How can I get the best results from AfterPill? You have 72 ...
Mifepristone is a potent anti-glucocorticoid compound that effectively inhibits replication of both laboratory and clinical HIV isolates in vitro. This study will evaluate the anti-HIV activity and safety of 3 different doses of mifepristone in HIV infected people.. This study will last approximately 2 months. Participants will be randomly assigned to one of 4 study arms, and will receive either mifepristone or placebo daily for 28 days. Arm A participants will receive one of three doses of placebo; Arm B participants will receive 75 mg mifepristone; Arm C participants will receive 150 mg mifepristone; and Arm D participants will receive 225 mg mifepristone. A thorough neck and thyroid examination will be performed within 30 days prior to study entry. Blood collection and vital signs measurement will occur at study entry and Days 3, 7, 14, 21, 28, and 56. Urine collection and pill counts will also be done at some study visits. ...
Combe International, the makers of Vagisil, have entered the emergency contraceptive market. Here the companys CEO Keech Combe Shetty explains why the company is giving away $1 million in emergency contraception pills.
ReachMD is an XM Satelite Radio channel geared toward medical professionals. They discuss a wide variety of topics on their show and have a website where much of the radio content is archived. This podcast is an interview by a primary care physician with Dr. Robert Hatcher (of Contraceptive Technology fame) about emergency contraception. If…
A new study in the Journal of Adolescent Health finds that pharmacy staff frequently give teens misleading or incorrect information about emergency contraception that may prevent them from getting the medication.
Democratic senators have introduced a new bill to raise awareness about emergency contraception and make it available to rape survivors at federally funded hospitals.. The Emergency Contraception Access and Education Act of 2014 was introduced by Sen. Patty Murray (D-Wash.), with Sens. Elizabeth Warren (D-Mass.), Barbara Boxer (D-Calif.), Richard Blumenthal (D-Conn.) and Cory Booker (D-N.J.) signing on as co-sponsors. The bill would ensure that any hospital receiving Medicare or Medicaid funds provides accurate information and timely access to emergency contraception for survivors of sexual assault, regardless of whether or not they can pay for it. It would also require the Secretary of Health and Human Services to disseminate information on emergency contraception to pharmacists and health care providers.. ...
At 0.5mg/kg, Ulipristal Acetate, marketed as ELLA, is usable as a morning after pill. Its marketed as an inhibitor of ovulation, but the manufacturer admits that the operative mechanism depends on the timing of its use. Like RU-486, Ulipristone is an anti-progesterone. It stops the action of that hormone in the reproductive tract, inhibits proliferation of the endometrium, inhibits implantation, and kills the embryo.. When used as a morning after pill Ella accomplishes this very early, before implantation. At higher doses, this drug can kill later embryos and fetuses just like its twin mifepristone.. In many states, pharmacists and hospitals will be required to distribute Ulipristal acetate, in the same way that they are now forced to dispense Plan B, levonorgestrel, the other morning after pill. Ella is among the drugs recommended for free distribution under the upcoming Obamacare, which will exacerbate complicity of all tax payers with chemical abortion, and add to the problems of ...
I am 20 years old and my normal menstrual cycle length is 29-32 days. This month I took post coital pill levonorgestrel 1.5 mg on the 19th day of menstruation. I missed my this months period. I did a pregnancy test which came negative. |b|Is pregnancy possible or is it due to levonorgestrel|/b|? Please help.
Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body. Levonorgestrel is a form of progesterone, a female hormone important .... ...
Product Description High Purity Mifepristone CAS No. 84371-65-3 for Anti-Pregnancy Mifepristone Synonyms: Estra-4, 9-dien-3-one, 11-[4-(dimethylamino)- phenyl]-17-hydroxy-17-(1-propynyl)-, (11a, - 17a)-Mifepristone; 17-beta-Hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oestra-4, 9-dien-3-one Inchi: InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26, 29)2)19-6-9-21(10-7-19)30(3)4/h6-7, 9-10, 17, 24-26, 32H, 8, 11-14, 16, 18H2, 1-4H3/t24-, 25+, 26-, 28-, 29-/m0/s1 CAS No.: 84371-65-3 MF: C29H35NO2 MW: 429.59 Purity: 99%min Density: 1.18 g/cm3 Melting Point: 195-198° C Boiling Point:…
Tamoxifen is both the most widely prescribed drug for breast cancer and preventative therapy worldwide. It is a synthetic derivative of triphenylethylene but was originally screened in a drug development program oriented toward discovering new post-coital contraceptive agents.
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Im sure that Eric S. Raymond, composer of the satanic homosexual [goatse.cx] propaganda diatribe The Cathedral and the Bizarre, is probably an anagram of something queer, but we dont need to look that far as we know hes always shoving a gun up some poor little boys rectum. Update: Eric S. Raymond is actually an anagram for secondary rim and cord in my arse. It just goes to show you that he is indeed queer.. Update the Second: It is also documented that Evil Sicko Gaymond is responsible for a nauseating piece of code called Fetchmail [microsoft.com], which is obviously sinister sodomite slang for Felch Male -- a disgusting practise. For those not in the know, felching is the act performed by two perverts wherein one sucks their own post-coital ejaculate out of the others rectum. In fact, it appears that the dirty Linux faggots set out to undermine the good Republican institution of e-mail, turning it into e-male.. As far as Richard Master Stallman goes, that filthy fudge-packer was ...
The theme of the article was a speculation that Southern LNG will abandon its plan to send 58 trucks a day out of their facility at Elba Island and instead receive 116 trucks of LNG per day, essentially doubling the risk to Savannah. The article went on to describe the huge gas finds in the United States and plans to reverse flow in certain connecting gas pipelines. The implication is that if gas flows can easily be reversed, the LNG flows can easily be reversed.. Let me qualify my experience in LNG. It has been 26 years since I left the job, but I was the first manager of the Trunkline LNG facility in Lake Charles, La.. The idea that making LNG from natural gas can be done easily is seriously flawed. Your readers well know the cost of cooling the air in their house from 95 to 75 degrees on a hot Savannah day. Imagine the energy required to cool natural gas to 260 degrees below zero. The only American LNG import that has received federal (FERC) approval to convert to LNG export is the Sabine ...
Continuing Care Depending on the patientвs physical status and the availability of family assistance, a home care referral may be indicated. 4.
Abortus technieken en methoden Noodanticonceptie: Hormonale methoden door inname van hoge dosissen oestrogenen: Klassieke noodpil (of Yuzpe-methode) of morning-afterpil (MAP), Levonorgestrel (LNG) (progestogeen-enkelpil, noodpil, morning-afterpil), Mifepristone of abortuspil (RU486) - Mechanische Methode: Abortus tijdens het 1e trimester van de zwangerschap: Abortuspil, Vacu maspiratie, Het embryo wordt opgezogen en vervolgens in delen opgevangen, Dilatatie en Curettage. Abortus tijdens het 2e trimester van de zwangerschap: Prostaglandinen, (Te) vroege keizersnede of ...
Infertility is the inability to get pregnant after a year of unprotected intercourse. Many couples in our life are affected by infertility.
Subissez-vous une grossesse non désirée? Cliquez ici. Ce service en ligne daide à lavortement médicamenteux soutient les femmes pour quelles aient accès à des avortements médicalisés. ...
Product Description COBRA ENTERPRISES Long Bore .38 Special 3.5 Inch Barrel Black Finish Black Grips Steel barrel, steel breech block insert, steel striker type firing mechanisms, positive p
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In addition, only 15% of women aged 18-45 who have been offered or have accessed emergency contraception say they have been offered the copper IUD. FSRH is concerned that these findings demonstrate a lack of awareness amongst women about the most effective form of emergency contraception. The findings also demonstrate a need for more visible guidance for healthcare professionals in this area to ensure that women are offered the copper IUD as the most effective form of emergency contraception.. Today FSRH launches its new Emergency Contraception guideline, which aims to bridge this gap in awareness and knowledge. The guideline gives clear evidence-based information to UK healthcare professionals, nurses, doctors, pharmacists and all those involved in advising and caring for women who wish access emergency contraception.. In line with NICE guidance, recommendations mark a new emphasis on healthcare professionals advising women that the copper IUD, is the most effective method of emergency ...
... PARIS June 17...The committees vote followed a review of data from the ulipristal ace... HRA Pharma is pleased with the outcome of the Advisory Committees vo...The FDA is currently reviewing HRA Pharmas New Drug Application (NDA)...,FDA,Advisory,Committee,Unanimously,Recommends,Approval,of,HRA,Pharmas,Ulipristal,Acetate,for,Emergency,Contraception,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health

Mifepristonum [Latin]
        -
        Menstruation-Inducing Agents,  Luteolytic Agents,  Contraceptives, Oral, Synthetic, ...Mifepristonum [Latin] - Menstruation-Inducing Agents, Luteolytic Agents, Contraceptives, Oral, Synthetic, ...

Contraceptives, Oral, Synthetic. * Contraceptives, Postcoital, Synthetic. * Hormone Antagonists. * Abortifacient Agents, ... Mifepristone is a synthetic steroid with antiprogestational effects indicated for the medical termination of intrauterine ...
more infohttp://pharmacycode.com/Mifepristonum_%5BLatin%5D.html

S9005 Mifepristone in Meningioma - Full Text View - ClinicalTrials.govS9005 Mifepristone in Meningioma - Full Text View - ClinicalTrials.gov

Contraceptive Agents, Female. Contraceptive Agents. Contraceptives, Postcoital, Synthetic. Contraceptives, Postcoital. Hormone ... women and men of reproductive potential may not participate unless they have agreed to use an effective local contraceptive ... Contraceptives, Oral, Synthetic. Contraceptives, Oral. ...
more infohttps://clinicaltrials.gov/ct2/show/NCT03015701

Mifepristone Treatment of Alcohol Use Disorder - Full Text View - ClinicalTrials.govMifepristone Treatment of Alcohol Use Disorder - Full Text View - ClinicalTrials.gov

Contraceptive Agents, Female. Contraceptive Agents. Contraceptives, Postcoital, Synthetic. Contraceptives, Postcoital. Hormone ... Contraceptives, Oral, Synthetic. Contraceptives, Oral. ...
more infohttps://clinicaltrials.gov/ct2/show/NCT02179749?term=Mifepristone+Treatment+of+alcohol+Use+Disorder&

A Study of Mifepristone vs. Placebo in the Treatment of Patients With Major Depression With Psychotic Features - Full Text View...A Study of Mifepristone vs. Placebo in the Treatment of Patients With Major Depression With Psychotic Features - Full Text View...

Contraceptive Agents, Female. Contraceptive Agents. Contraceptives, Postcoital, Synthetic. Contraceptives, Postcoital. Hormone ... Contraceptives, Oral, Synthetic. Contraceptives, Oral. ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT00637494

C Category Names List - Drug Information Portal - U.S. National Library of MedicineC Category Names List - Drug Information Portal - U.S. National Library of Medicine

Contraceptives, Postcoital, Synthetic (3) • Postcoital contraceptives which owe their effectiveness to synthetic preparations. ... Contraceptives, Oral, Synthetic (28) • Oral contraceptives which owe their effectiveness to synthetic preparations. MeSH ... Contraceptives, Postcoital, Hormonal (1) • Postcoital contraceptives which owe their effectiveness to hormonal preparations. ... Contraceptives, Postcoital (8) • Contraceptive substances to be used after COITUS. These agents include high doses of ...
more infohttps://druginfo.nlm.nih.gov/drugportal/drug/categories/c

NAVER Academic > Search...NAVER Academic > Search...

Animals, Contraceptives, Postcoital, pharmacology, Contraceptives, Postcoital, Synthetic, administration & dosage, Eflornithine ... The effect of cotrimoxazole on oral contraceptive steroids in women. 1983 Grimmer S.F.M et al. Contraception cited 9 times ... Urinary concentrations of steroid glucuronides in women taking oral contraceptives. 1983 Shaw M.A et al. Contraception cited 1 ... Ten Egyptian women who were using the injectable contraceptive norethisterone oenanthate (NET-OEN) for at least 6 months were ...
more infohttps://academic.naver.com/search.naver?field=3&query=Contraception+28%EA%B6%8C+1%ED%98%B8

Effects of SH T00658ID on Libido - Full Text View - ClinicalTrials.govEffects of SH T00658ID on Libido - Full Text View - ClinicalTrials.gov

Contraceptive Agents, Female. Contraceptives, Oral, Synthetic. Contraceptive Agents, Male. Hormone Antagonists. Antineoplastic ... Contraindications for oral contraceptive use, for example but not limited to: presence or history of venous or arterial ... Contraceptives, Oral. Estradiol. Polyestradiol phosphate. Ethinyl Estradiol. Estrogens. Hormones. Hormones, Hormone Substitutes ... The aim of the study is to investigate whether women on oral contraceptives (OCs) suffering from acquired OC-associated female ...
more infohttps://www.clinicaltrials.gov/ct2/show/NCT00764881

Results from pooled Phase III studies of ulipristal acetate for emergency contraception.  - PubMed - NCBIResults from pooled Phase III studies of ulipristal acetate for emergency contraception. - PubMed - NCBI

Contraceptives, Postcoital, Synthetic. *Norpregnadienes. *Receptors, Progesterone. *ulipristal acetate. Grant support. *R24 ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/22770793?dopt=Abstract

Mifepristone was more effective than the Yuzpe regimen for emergency contraception | Evidence-Based NursingMifepristone was more effective than the Yuzpe regimen for emergency contraception | Evidence-Based Nursing

contraceptives (postcoital synthetic). *ethinyl estradiol. *levonorgestrel. *mifepristone. Ashok PW, Stalder C, Wagaarachchi PT ... mifepristone given in a 100 mg dose was a more effective post-coital contraceptive than the Yuzpe regimen. ... Mifepristone (RU 486) compared with high-dose estrogen and progestogen for emergency postcoital contraception. N Eng J Med 1992 ... Webb AM, Russell J, Elstein M. Comparison of Yuzpe regimen, danazol, and mifepristone (RU486) in oral postcoital contraception ...
more infohttp://ebn.bmj.com/content/6/1/14.full?related-urls=yes&legid=ebnurs

Tamoxifen MechanismTamoxifen Mechanism

... but was originally screened in a drug development program oriented toward discovering new post-coital contraceptive agents. ... It is a synthetic derivative of triphenylethylene but was originally screened in a drug development program oriented toward ... discovering new post-coital contraceptive agents.. In its testing, tamoxifen had proved effective in rats but not in women. It ... It is a synthetic derivative of triphenylethylene ...
more infohttps://www.news-medical.net/health/Tamoxifen-Mechanism.aspx

Fenestrel - WikipediaFenestrel - Wikipedia

... nonsteroidal estrogen that was developed as a postcoital contraceptive in the 1960s but was never marketed. Synthesized by ... Fenestrel (INN, USAN) (developmental code name ORF-3858) is a synthetic, ... 517-. ISBN 978-1-4757-2085-3. Revaz C, Goldenberg B, Achtari H (1971). "[Critical study of new contraceptive methods]". Schweiz ... Ortho Pharmaceutical in 1961 and studied extensively, it was coined the "morning-after-pill" or "postcoital antifertility agent ...
more infohttps://en.wikipedia.org/wiki/Fenestrel

DES 1st generation Archives - Diethylstilbestrol DESDES 1st generation Archives - Diethylstilbestrol DES

In February 1975, the FDA said it had not yet approved DES as a postcoital contraceptive, but would after March 8, 1975 permit ... contraceptive) use of diethylstilbestrol (DES), a synthetic estrogen. ... In May 1973, in an attempt to restrict off-label use of DES as a postcoital contraceptive to emergency situations such as rape ... To discourage off-label use of DES as a postcoital contraceptive, in February 1975 the FDA ordered DES 25 mg (and higher) ...
more infohttps://diethylstilbestrol.co.uk/tag/des-1st-generation/

Food and Drug Administration Archives - Diethylstilbestrol DESFood and Drug Administration Archives - Diethylstilbestrol DES

In February 1975, the FDA said it had not yet approved DES as a postcoital contraceptive, but would after March 8, 1975 permit ... contraceptive) use of diethylstilbestrol (DES), a synthetic estrogen. ... In May 1973, in an attempt to restrict off-label use of DES as a postcoital contraceptive to emergency situations such as rape ... To discourage off-label use of DES as a postcoital contraceptive, in February 1975 the FDA ordered DES 25 mg (and higher) ...
more infohttps://diethylstilbestrol.co.uk/tag/food-and-drug-administration/

Anordiol - WikipediaAnordiol - Wikipedia

... a postcoital contraceptive that is marketed and used in China. Relative to anordrin, anordiol has similar but more potent ... Anordiol, or anordriol, also known as 2α,17α-diethynyl-A-nor-5α-androstane-2β,17β-diol, is a synthetic steroid-like mixed ...
more infohttps://en.wikipedia.org/wiki/Anordiol

Drug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug InformationDrug Information Portal - U.S. National Library of Medicine - Quick Access to Quality Drug Information

Info Contraceptives, Oral, Synthetic. * Info Contraceptives, Postcoital. * Info Contraceptives, Postcoital, Synthetic. * Info ...
more infohttps://druginfo.nlm.nih.gov/drugportal/name/Mifepristone

Private Drugstore: Chemical name of viagra all brand pills!Private Drugstore: Chemical name of viagra all brand pills!

... a semi-synthetic derivative of camptothecin, is an effective postcoital contraceptive and do not rush. General somatic ...
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conditions: Poconditions: Po

Postcoital Contraceptive Agents, Synthetic. *Postcoital Contraceptives. *Postcoital Contraceptives, Synthetic. *Postcoital ...
more infohttp://conditions.healthplace.com/sections/Po

NNRTI Drug Interactions | Drug-Drug Interactions | Adult and Adolescent ARV | AIDSinfoNNRTI Drug Interactions | Drug-Drug Interactions | Adult and Adolescent ARV | AIDSinfo

Effectiveness of emergency postcoital contraception may be diminished.. Menopausal Hormone Replacement Therapy. EFV, ETR, NVP. ... Hormonal Contraceptives. EFV. Ethinyl estradiol ↔ Levonorgestrel (metabolite of oral norgestimate) AUC ↓ 83% Norelgestromin ( ... With estradiol or conjugated estrogen (equine and synthetic): ↓ estrogen possible ↓ medroxyprogesterone possible ↓ micronized ... See Hormonal Contraceptives for other progestin-NNRTI interactions Monitor menopausal symptoms. The lowest dose of hormonal ...
more infohttps://aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-arv-guidelines/285/nnrti-drug-interactions

Unmasking the Ella Masquerade: Blurring the Line Between Contraception and AbortionUnmasking the 'Ella' Masquerade: Blurring the Line Between Contraception and Abortion

Chemical contraceptives, both long-term and emergency, use a synthetic version of the hormone progestin. Progestin has effects ... Ella boasts of 120 hours (5 days) of post-coital effectiveness. The drug is produced by the Paris-based pharmaceutical company ... 1] Levonogestrel is also the active ingredient in the Intra-uterine contraceptive Mirena and the contraceptive implants ... But Ella (generic name ulipristal acetate) is not a synthetic progestin that mimics the action of progesterone. The FDA press ...
more infohttps://www.culture-of-life.org/2010/08/26/unmasking-the-ella-masquerade-blurring-the-line-between-contraception-and-abortion/

Types of Emergency Contraception Pills - Our Bodies OurselvesTypes of Emergency Contraception Pills - Our Bodies Ourselves

Emergency contraceptive pills (ECPs), also known as "postcoital contraception" or the "morning-after pill," work by changing a ... They give the body a short, high burst of synthetic hormones that disrupt natural hormone production needed for ovulation and ... Some people call emergency contraceptive pills "morning-after pills." But you do not have to wait until the morning after. You ... The FDA currently approves three different types of emergency contraceptive pills: pills that contain only progestin, pills ...
more infohttps://www.ourbodiesourselves.org/book-excerpts/health-article/types-of-emergency-contraception-pills/

Diethylstilbestrol - WikipediaDiethylstilbestrol - Wikipedia

As an emergency postcoital contraceptive. *As a means of chemical castration for hypersexuality and paraphilias in men and sex ... Synthetic. 40-60. 2.9-4.3. ND. ND Addendum: The ovulation-inhibiting dose (OID) of ethinylestradiol is 0.1 mg/day.[44] ... In 1973, in an attempt to restrict off-label use of DES as a postcoital contraceptive (which had become prevalent at many ... regimen of certain regular combined oral contraceptive pills superseded off-label use of DES as a postcoital contraceptive.[92] ...
more infohttps://en.m.wikipedia.org/wiki/Diethylstilbestrol

Emergency Postcoital Contraception - American Family PhysicianEmergency Postcoital Contraception - American Family Physician

... dedicated products or can be adapted for use from standard oral contraceptive pills. Emergency postcoital contraception should ... Emergency postcoital contraception, a method used to prevent pregnancy after unprotected sexual intercourse, is a highly ... the antiprogestin synthetic steroid RU 486 (mifepristone; Mifeprex), estrogen alone (high-dose ethinyl estradiol) and the ... 7. Vasilakis C, Jick SS, Jick H. The risk of venous thromboembolism in users of postcoital contraceptive pills. Contraception. ...
more infohttps://www.aafp.org/afp/2000/1115/p2287.html

Lifestyles Condoms. If you had an intercourse and suspect that you areLifestyles Condoms. If you had an intercourse and suspect that you are

The pill is also known as the "Morning After" pill or as post-coital contraception, the emergency pill works within three days ... Emergency Contraceptives reduce the likelihood of becoming pregnant but do not protect against sexually transmitted diseases. ... bursts of synthetic that disrupts hormone patterns needed for pregnancy. EC is used within 120 hours after the intercourse and ... pregnancy can be prevented even after the intercourse by taking the Emergency Contraceptives pills (EC). These pills give the ...
more infohttp://ndri.com/news/lifestyles_condoms-189.html

Search | The Embryo Project EncyclopediaSearch | The Embryo Project Encyclopedia

Plan B: Emergency Contraceptive Pill. Plan B is a progestin-only emergency contraceptive pill (ECP) that can be taken within ... Post-Coital Oral Emergency Contraception. Post-coital oral emergency contraception is used for the prevention of pregnancy ... Progestin: Synthetic Progesterone. Progestin is a synthetic form of progesterone, a naturally occurring hormone, which plays an ... The first contraceptive pill, called Enovid, had been on the market since June 1960, and Rock was one of the leading ...
more infohttps://embryo.asu.edu/search?text=oral%20contraceptive%20pill

Mifepristone - DrugBankMifepristone - DrugBank

Contraceptives, Oral, Synthetic. *Contraceptives, Postcoital. *Cytochrome P-450 CYP2C8 Inhibitors. *Cytochrome P-450 CYP2C8 ... Mifepristone is a synthetic steroid with antiprogestational effects indicated for the medical termination of intrauterine ... activity and progestin and glucocorticoid receptor binding of the putative metabolites and synthetic derivatives of CDB-2914, ...
more infohttps://www.drugbank.ca/drugs/DB00834
  • Nine women taking long-term oral contraceptive steroids (Trinordiol) were studied during a cycle while taking cotrimoxazole (1 gm twice daily) and the results were compared to. (naver.com)
  • The aim of the study is to investigate whether women on oral contraceptives (OCs) suffering from acquired OC-associated female sexual dysfunction (FSD) for at least 3 months but no longer than one year will express the same level of sexual distress when taking SH T00658ID compared to Microgynon, the usual OC prescribed for women with OC-associated FSD. (clinicaltrials.gov)
  • Exclusion criteria were use of oral contraceptives or hepatic enzyme inducing drugs, chronic adrenal failure, long term corticosteroid treatment, breast feeding, allergy, or contraindications to mifepristone or to oestrogen and progestogen. (bmj.com)
  • These regimens are packaged as Food and Drug Administration labeled, dedicated products or can be adapted for use from standard oral contraceptive pills. (aafp.org)
  • As one of the researchers involved in the development of the oral contraceptive pill, Min Chueh Chang helped to revolutionize the birth control movement. (asu.edu)
  • Born on 24 March 1890 in Marlborough, Massachusetts, to Ann and Frank Rock, John Charles Rock was both a devout Catholic and one of the leading investigators involved in the development of the first oral contraceptive pill. (asu.edu)
  • Katharine Dexter McCormick, who contributed the majority of funding for the development of the oral contraceptive pill, was born to Josephine and Wirt Dexter on 27 August 1875 in Dexter, Michigan. (asu.edu)
  • Gregory Goodwin Pincus, one of the original researchers responsible for the development of the first oral contraceptive pill, was born in Woodbine, New Jersey, on 19 April 1903 to Russian Jewish parents. (asu.edu)
  • The oral contraceptive, "the pill," was the first available method of delivery, and it is still widely used. (earthslab.com)
  • D-norgestrel in a postcoital regimen alters pituitary and ovarian function, strongly suggesting an antiovulatory effect. (who.int)
  • Birth control methods may be categorized into several groups based on their mode of action: hormonal, chemical and behavioral contraceptive methods, anti-implantation devices, sterilization, and induced abortion. (earthslab.com)
  • However, because existing data support the possibility of delayed appearance of carcinoma in females whose mothers have been given DES later in pregnancy, and because teratogenic and other adverse effects on the fetus with the very early administration recommended are ill understood, failure of postcoital treatment with DES deserves serious consideration of voluntary termination of pregnancy. (diethylstilbestrol.co.uk)
  • Plan B is a progestin-only emergency contraceptive pill (ECP) that can be taken within seventy-two hours of unprotected sex in order to prevent an unwanted pregnancy. (asu.edu)
  • Ten Egyptian women who were using the injectable contraceptive norethisterone oenanthate (NET-OEN) for at least 6 months were monitored weeekly for a period of 12 weeks. (naver.com)
  • Multinational comparative clinical trial of long-acting injectable contraceptives: Norethisterone enanthate given in two dosage regimens and depot-medroxyprogesterone acetate. (naver.com)
  • The Agency considers the use of DES for this purpose to be safe only as an emergency measure (in situations such as rape, incest, or where, in the physician's judgment, the patient's physical or mental well-being is in jeopardy) and explicitly warns against its routine or frequent use as a contraceptive. (diethylstilbestrol.co.uk)
  • In May 1973 , in an attempt to restrict off-label use of DES as a postcoital contraceptive to emergency situations such as rape, a FDA Drug Bulletin was sent to all U.S. physicians and pharmacists that said the FDA had approved, under restricted conditions , postcoital contraceptive use of DES. (diethylstilbestrol.co.uk)
  • In September 1973 , the FDA published a proposed rule specifying patient labeling and special packaging requirements for any manufacturer seeking FDA approval to market DES as a postcoital contraceptive, inviting manufacturers to submit abbreviated new drug applications (ANDAs) for that indication, and notifying manufacturers that the FDA intended to order the withdrawal of DES 25 mg tablets (which were being used off-label as postcoital contraceptives). (diethylstilbestrol.co.uk)
  • With the substance STS 456, an estrogenic active steroid, a high fertility inhibition could be obtained in the pavian, when administered p. o. over a 5 day period postcoital. (who.int)
  • There is at present no positive evidence that the restricted postcoital use of DES carries a significant carcinogenic risk either to the mother or fetus. (diethylstilbestrol.co.uk)