Contraceptives, Oral, Combined
Contraceptives, Oral, Hormonal
Contraceptive Agents, Female
Contraceptives, Oral, Synthetic
Contraceptive Agents, Male
Family Planning Services
A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
Intrauterine Devices, Copper
Ethinyl Estradiol-Norgestrel Combination
Contraceptives, Oral, Sequential
Contraceptives, Postcoital, Hormonal
The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.
Health Knowledge, Attitudes, Practice
Contraceptives, Postcoital, Synthetic
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Nonoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide, formulated primarily as a component of vaginal foams and creams.
Reproductive Health Services
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
An important aggregate factor in epidemiological studies of women's health. The concept usually includes the number and timing of pregnancies and their outcomes, the incidence of breast feeding, and may include age of menarche and menopause, regularity of menstruation, fertility, gynecological or obstetric problems, or contraceptive usage.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Family Planning Policy
Natural Family Planning Methods
A class of natural contraceptive methods in which SEXUAL ABSTINENCE is practiced a few days before and after the estimated day of ovulation, during the fertile phase. Methods for determining the fertile period or OVULATION DETECTION are based on various physiological indicators, such as circulating hormones, changes in cervical mucus (CERVIX MUCUS), and the basal body temperature.
A medical-surgical specialty concerned with the morphology, physiology, biochemistry, and pathology of reproduction in man and other animals, and on the biological, medical, and veterinary problems of fertility and lactation. It includes ovulation induction, diagnosis of infertility and recurrent pregnancy loss, and assisted reproductive technologies such as embryo transfer, in vitro fertilization, and intrafallopian transfer of zygotes. (From Infertility and Reproductive Medicine Clinics of North America, Foreword 1990; Journal of Reproduction and Fertility, Notice to Contributors, Jan 1979)
Women's Health Services
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Health Services Accessibility
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
Indians, Central American
Ambulatory Care Facilities
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
Hormone Replacement Therapy
Gonadal Steroid Hormones
Interviews as Topic
Vaginal Creams, Foams, and Jellies
Medicated dosage forms for topical application in the vagina. A cream is a semisolid emulsion containing suspended or dissolved medication; a foam is a dispersion of a gas in a medicated liquid resulting in a light, frothy mass; a jelly is a colloidal semisolid mass of a water soluble medicated material, usually translucent.
Estrogen Replacement Therapy
The use of hormonal agents with estrogen-like activity in postmenopausal or other estrogen-deficient women to alleviate effects of hormone deficiency, such as vasomotor symptoms, DYSPAREUNIA, and progressive development of OSTEOPOROSIS. This may also include the use of progestational agents in combination therapy.
A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
Intrauterine Device Migration
Student Health Services
Interference with the FREEDOM or PERSONAL AUTONOMY of another person, with justifications referring to the promotion of the person's good or the prevention of harm to the person. (from Cambridge Dictionary of Philosophy, 1995); more generally, not allowing a person to make decisions on his or her own behalf.
One of the Indian Ocean Islands off the southeast coast of Africa. Its capital is Antananarivo. It was formerly called the Malagasy Republic. Discovered by the Portuguese in 1500, its history has been tied predominantly to the French, becoming a French protectorate in 1882, a French colony in 1896, and a territory within the French union in 1946. The Malagasy Republic was established in the French Community in 1958 but it achieved independence in 1960. Its name was changed to Madagascar in 1975. (From Webster's New Geographical Dictionary, 1988, p714)
Pelvic Inflammatory Disease
A spectrum of inflammation involving the female upper genital tract and the supporting tissues. It is usually caused by an ascending infection of organisms from the endocervix. Infection may be confined to the uterus (ENDOMETRITIS), the FALLOPIAN TUBES; (SALPINGITIS); the ovaries (OOPHORITIS), the supporting ligaments (PARAMETRITIS), or may involve several of the above uterine appendages. Such inflammation can lead to functional impairment and infertility.
The effects of different formulations of oral contraceptive agents on lipid and carbohydrate metabolism. (1/5)BACKGROUND: Oral contraceptives can induce changes in lipid and carbohydrate metabolism similar to those associated with an increased risk of coronary heart disease, including increased serum triglyceride, low-density lipoprotein (LDL) cholesterol, and insulin levels and decreased high-density lipoprotein (HDL) cholesterol levels. In this study, we examined whether modification of the type or dose of progestin in oral-contraceptive preparations diminishes these changes. METHODS: We measured plasma lipoprotein levels and performed oral glucose-tolerance tests in a cross section of 1060 women who took one of nine types of oral contraceptives for at least three months and 418 women who took none. Seven of the contraceptive formulations contained various doses and types of progestin: levonorgestrel in low (150 micrograms), high (250 micrograms), and triphasic (50 to 125 micrograms) doses; norethindrone in low (500 micrograms), high (1000 micrograms), and triphasic (500 to 1000 micrograms) doses; and a new progestin, desogestrel, in one dose (150 micrograms). All seven contained 30 to 40 micrograms of ethinyl estradiol. Two additional formulations contained progestin alone. RESULTS: As compared with controls, women taking combination drugs did not have increased serum total cholesterol levels but did have increases of 13 to 75 percent in fasting triglyceride levels. Levels of LDL cholesterol were reduced by 14 percent in women taking the combination containing desogestrel and by 12 percent in those taking low-dose norethindrone. Levels of HDL cholesterol were lowered by 5 percent and 16 percent by the combinations containing low-dose and high-dose levonorgestrel, respectively; these decreases were due to reductions of 29 percent and 43 percent, respectively, in the levels of HDL subclass 2. The combination pill containing high-dose norethindrone did not affect HDL cholesterol levels, whereas that containing low-dose norethindrone increased HDL cholesterol levels by 10 percent. The desogestrel combination increased HDL cholesterol levels by 12 percent. Levels of apolipoproteins A-I, A-II, and B were generally increased by combination drugs. Depending on the dose and type of progestin, combination drugs were associated with plasma glucose levels on the glucose-tolerance test that were 43 to 61 percent higher than in controls, insulin responses 12 to 40 percent higher, and C-peptide responses 18 to 45 percent higher. Progestin-only formulations had only minor metabolic effects. CONCLUSIONS: The appropriate dose and type of progestin may reduce the adverse effects of oral contraceptives on many metabolic markers of risk for coronary heart disease. Progestin-only formulations or combinations containing desogestrel or low-dose norethindrone were associated wtih the most favorable profiles. (+info)
Types of combined oral contraceptives used by US women. (2/5)(+info)
The epidemiology of endometrial cancer in young women. (3/5)A case-control study was conducted in Los Angeles County, California, of 127 endometrial cancer cases aged 45 years or less at diagnosis, to investigate the role of fertility, obesity and exogenous oestrogens in the development of the disease in young women. Use of sequential oral contraceptive (SOCs) or oestrogen replacement therapy (ERT) for greater than or equal to 2 years was strongly associated with increased risk of endometrial cancer. After excluding these cases, since the SOC or ERT use was probably the cause of their disease, we were left with 110 case-control pairs for further study. Among these remaining case-control pairs increasing parity was strongly associated with decreased risk (relative risk of 0.12 for women of parity 3 compared to nulliparous women, P less than 0.001). Current weight was associated with increased risk (relative risk of 17.7 for women weighing greater than or equal to 190 lbs compared to women weighing less than 130 lbs, P less than 0.001). Combination oral contraceptive (COC) use was associated with a decreased risk, which decreased with duration of COC use (relative risk of approximately 0.28 at 5 years of use, P less than 0.001), but the estimate of the protective effect was reduced and became statistically non-significant when allowance was made for weight and parity. The protective effect of COC use was only clearly evident in women who had less than 3 live-births and weighed less than 170 lbs. These results provide further support for the "unopposed" oestrogen hypothesis of the aetiology of endometrial cancer. (+info)
The effect of kind of carbohydrate in the diet and use of oral contraceptives on metabolism of young women. II. Serum lipid levels. (4/5)The response of lipids in the blood between two groups of six young women was compared. Group 1 took oral contraceptives and group 2 had never taken oral contraceptives. Two experimental diets supplied about 13% of the calories from protein, 36% from fat, and 51% from carbohydrate. Of the carbohydrate, 84% was either sucrose or wheat starch. Each diet was fed for 4 weeks in a cross-over design. In the portion of the research presented here, subjects were fed a high sucrose meal before each dietary period and after weeks 1 and 3 of each dietary period. Blood lipids were measured before and 30, 60, 120, and 180 min after each meal. Cholesterol and lipoproteins were not affected by the sucrose meal, but free fatty acid levels decreased significantly in both groups. The serum levels of triglycerides, beta-lipoproteins, and cholesterol were significantly higher in users than in nonusers of oral contraceptives. Free fatty acid levels were affected by an interaction between diet and time, and the decrease in response was greater after the sucrose than after the wheat starch diet. Triglycerides, cholesterol, and total lipids were not significantly different after the two carbohydrate diets. (+info)
In vitro and in vivo metabolism of desogestrel in several species. (5/5)The metabolism of desogestrel (13-ethyl-11-methylene-18, 19-dinor-17alpha-pregn-4-en-20-yn-17-ol), an orally active progestogen, was studied in vivo after administration of single oral doses to rats and dogs and in vitro using rat, rabbit, dog, and human liver microsomes. Metabolites were isolated and identified by NMR and MS analysis. After oral administration of [3H]desogestrel to rats and dogs, desogestrel was extensively metabolized in both species. Radioactivity was predominantly eliminated in the feces. In rats, desogestrel was metabolized mainly at the C3-, C5-, C11-, and C15-positions. Both in vivo and in vitro, the majority of metabolites were 3alpha-hydroxy,4,5alpha-dihydro derivatives. Other main metabolic routes for desogestrel in rats were 15alpha-hydroxylation and epoxidation of the C11-methylene moiety. In addition to phase I metabolites, glucuronic acid and sulfate conjugates of desogestrel were observed in vivo. In dogs, desogestrel was mainly metabolized at the C3- and C17-positions. In contrast to the rat metabolites, metabolites isolated from dog urine or feces were mainly 3beta-hydroxy,4,5alpha-dihydro derivatives. In most of the metabolites present in dog urine and feces, the five-membered D-ring was expanded to a six-membered D-ring, i.e. D-homoannulation to a 17A-keto-D-homo ring. D-Homo metabolites, which were major metabolites in plasma, urine, and feces of dogs, were not observed in vitro. In dog liver microsomes, the 3-keto metabolite of desogestrel was the major metabolite. Similarly to dog liver microsomes, rabbit and human liver microsomes mainly converted desogestrel to its 3-keto metabolite. Predominant positions for further hydroxylation of the 3-keto metabolite of desogestrel were the C6-position (6beta-hydroxy) and the ethyl substituent at the C13-position, for both species. (+info)
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Dimethisterone: A synthetic progestational hormone without significant estrogenic or androgenic properties. It was formerly used as the progestational component in oral sequential contraceptives.
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Desogestrel, sold under the brand names Cerazette and Mircette among many others, is a progestin medication which is used in birth control pills for women. It is also used for the treatment of menopausal symptoms in women. The medication is used alone or in combination with an estrogen. It is taken by mouth. Side effects of desogestrel include menstrual irregularities, headaches, nausea, breast tenderness, mood changes, acne, increased hair growth, and others. Desogestrel is a progestin, or a synthetic progestogen, and hence is an agonist of the progesterone receptor, the biological target of progestogens like progesterone. It has very weak androgenic activity and no other important hormonal activity. The medication is a prodrug of etonogestrel in the body. Desogestrel was first described in 1975 and was introduced for medical use in Europe in 1981. It became available in the United States in 1992. Desogestrel is sometimes referred to as a third-generation progestin. Along with norethisterone, ...
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There is a well-documented reduction in endometrial cancer (EC) risk with combined oral contraceptive (COC) use. COC use prior to the first full-term pregnancy may affect breast cancer risk for decades, but this relationship has not been investigated in EC. We investigated the risk for EC with COC use prior to the first full-term pregnancy. Cases (n=524) from a population-based cancer registry and age-matched controls (n=1032) were recruited between 2002 and 2006 in Alberta, Canada. Participants completed an in-person interview and provided detailed information on exogenous hormone use and other risk factors. Risk reductions in EC with COC use over the premenopausal years were consistent with the published literature. We also found evidence of a long-term, significant risk reduction in parous women with COC use prior to the first full-term pregnancy. Among parous women, ≥5 years of COC use prior to a first full-term pregnancy was associated with a significant reduction in risk (adjusted ...
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These reports investigated the association between new continuous or extended combined oral contraceptive (COC) use and venous thromboembolism (VTE), with new cyclic COC use as the comparison exposure. These reports also contain results from six sensitivity analyses with varying exposure incidence criteria, stroke definitions, follow-up periods, or exposure groups. Data from May 22, 2007 to September 30, 2015 from 12 Data Partners contributing to the Sentinel Distributed Database were included in this report. This request was distributed to Data Partners on March 28, 2017 ...
Cerazette tablets are a type of hormonal contraceptive commonly known as the mini pill or progestogen-only pill (POP). They contain the active ingredient desogestrel, which is a synthetic progestogen, similar to the natural progestogens produced by the body.
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The low-density lipoprotein receptor-related protein 4 (LRP4) is essential in muscle fibers for the establishment of the neuromuscular junction. Here, we show that LRP4 is also expressed by embryonic cortical and hippocampal neurons, and that downregulation of LRP4 in these neurons causes a reduction in density of synapses and number of primary dendrites. Accordingly, overexpression of LRP4 in cultured neurons had the opposite effect inducing more but shorter primary dendrites with an increased number of spines. Transsynaptic tracing mediated by rabies virus revealed a reduced number of neurons presynaptic to the cortical neurons in which LRP4 was knocked down. Moreover, neuron-specific knockdown of LRP4 by in utero electroporation of LRP4 miRNA in vivo also resulted in neurons with fewer primary dendrites and a lower density of spines in the developing cortex and hippocampus. Collectively, our results demonstrate an essential and novel role of neuronal LRP4 in dendritic development and ...
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Family Health International has recently initiated a USAID funded study to investigate the pregnancy rates, continuation rates, and acceptability of COCs in women taking COCs by the 21/7 cyclic regimen compared with the continuous use of COCs with bleeding-signaled hormone-free intervals. The primary objective is to determine whether continuous COC use leads to higher 12-month continuation rates than use of the standard 28-day COC regimen. Secondary objectives are to 1) compare pregnancy probabilities through 6 and 12 months between the continuous use group and the 28-day group 2) compare COC continuation rates through 6 months between the continuous use group and the 28-day group 3) compare acceptability of the two COC regimens 4) to compare bleeding and other side effects between the continuous use group and the 28-day group 5) to compare hemoglobin/hematocrit between the continuous use group and the 28-day ...
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The risk associated with the use of other sequential oral contraceptives remains unclear, mainly because these drugs are no ... It was introduced in the United States as an oral contraceptive in combination with high doses of ethinylestradiol under the ... Secrosteron a new oral progestational substance British Drug Houses (South Africa) (Pty.) Ltd., announce the introduction of ... It is the purpose of this paper to introduce and describe a new steroid for oral administration, 17-a-hydroxyprogesterone ...
... or by sustained use of oral contraceptives. Hormonal contraceptives prevent pregnancy by inhibiting the secretion of the ... Sequential dosing and discontinuation of the COC can mimic the uterine cycle and produce bleeding that resembles a period. In ... Hormonal contraception that contains estrogen, such as combined oral contraceptive pills (COCs, often referred to as birth ... Polis CB, Hussain R, Berry A (June 2018). "There might be blood: a scoping review on women's responses to contraceptive-induced ...
List of MeSH codes (D27)
... contraceptives, oral, hormonal MeSH D27.505.696.875.360.276.210.400 - contraceptives, oral, sequential MeSH D27.505.696.875. ... contraceptives, oral, hormonal MeSH D27.505.954.705.360.276.210.400 - contraceptives, oral, sequential MeSH D27.505.954.705. ... contraceptives, oral MeSH D27.505.696.875.360.276.210.100 - contraceptives, oral, combined MeSH D27.505.696.875.360.276.210.277 ... contraceptives, oral MeSH D27.505.954.705.360.276.210.100 - contraceptives, oral, combined MeSH D27.505.954.705.360.276.210.277 ...
... "sequential oral contraceptives which were removed from the consumer market in the 1970s was associated with an increased risk ... The original hormonal method-the combined oral contraceptive pill-was first marketed as a contraceptive in 1960. In the ensuing ... an oral progestin; off-label use of combined oral contraceptives (Yuzpe regimen); and the copper intrauterine device (Cu-IUD). ... Oral Contraceptives, Combined (Vol. 72 ed.). p. 49. "Combined Estrogen-Progestogen Contraceptives" (PDF). IARC Monographs on ...
It was the first sequential contraceptive pill to be introduced in the U.S. CMA has also been marketed in combination with ... In the 1960s, CMA was introduced as a component of oral contraceptives. However, around 1970, such formulations were withdrawn ... Edgren RA, Sturtevant FM (August 1976). "Potencies of oral contraceptives". Am. J. Obstet. Gynecol. 125 (8): 1029-38. doi: ... Bingel AS, Benoit PS (February 1973). "Oral contraceptives: therapeutics versus adverse reactions, with an outlook for the ...
The risk of breakthrough bleeding with oral contraceptives is greater if pills are missed. The Not Classified category of the ... consisting of both an estrogen and a progestogen A cut-off threshold of 5 mm or less should be used for women on sequential ... "Compliance and oral contraceptives: A review". Contraception. 52 (3): 137-141. doi:10.1016/0010-7824(95)00161-3. ISSN 0010-7824 ... "Increased risk of breakthrough bleeding when one oral-contraceptive tablet is missed". The New England Journal of Medicine. 296 ...
... are frequently managed by use of combined oral contraceptive pills.. Postmenopausal bleeding. In postmenopausal bleeding ... A cut-off threshold of 5 mm or less should be used for women on sequential hormone replacement therapy consisting both of an ... Women on hormonal contraceptives can experience breakthrough bleeding and/or withdrawal bleeding. Withdrawal bleeding occurs ... when a hormonal contraceptive or other hormonal intake is discontinued.. There are pathological causes of unusual vaginal ...
Besides oral contraceptives, other forms of combined hormonal contraception include contraceptive patches, contraceptive ... sequential estrogen-progestogen treatment (OR = 1.76) is associated with a lower risk increase than continuous treatment (OR = ... high doses of ethinylestradiol are no longer used in combined oral contraceptives, and all modern combined oral contraceptives ... Ethinylestradiol is generally used in oral contraceptives instead of estradiol because it has superior oral pharmacokinetics ( ...
Million Women Study
... for oral, transdermal and implanted HRT, and for continuous and sequential patterns of use. Current users of estrogen- ... Are breast cancers detected at screening in women who have used HRT or oral contraceptives different in terms of size and ... or between oral and transdermal (patch) administration. These results are equivalent to one extra case of ovarian cancer for ...
Major histocompatibility complex
... although with oral contraceptives, the women showed no particular preference. No studies show the extent to which odor ... The TCRs of T lymphocytes recognise only sequential epitopes, also called linear epitopes, of only peptides and only if coupled ... a preference reversed if the women were on oral contraceptives. Results of a 2002 experiment likewise suggest HLA-associated ...
It may alter the effectiveness of combined oral contraceptive pills because of its effect on the gut flora. A review found that ... Pal S (2006). "A journey across the sequential development of macrolides and ketolides related to erythromycin". Tetrahedron. ... ketoconazole and erythromycin on the steady-state pharmacokinetics of the components of a novel oral contraceptive containing ... oral suspension, tablets) erythromycin stearate (oral suspension, tablets) For injection, the available combinations are: ...
Oral megadoses of preformed vitamin A (retinyl palmitate), and all-trans-retinoic acid itself, also have teratogenic potential ... All-trans-retinoic acid can be produced in the body by two sequential oxidation steps that convert all-trans-retinol to ... Suppressing this enzyme has been proposed as a possible way to make a male contraceptive pill, because retinoic acid is ...
It may alter the effectiveness of combined oral contraceptive pills because of its effect on the gut flora. A review found that ... Pal S (2006). "A journey across the sequential development of macrolides and ketolides related to erythromycin". Tetrahedron. ... ketoconazole and erythromycin on the steady-state pharmacokinetics of the components of a novel oral contraceptive containing ... "Erythromycin Oral, Parenteral Advanced Patient Information". Drugs.com. Archived from the original on 2009-11-30.. ...
Pharmacology of cyproterone acetate
Oral CPA has been studied at low dosages of 5 to 20 mg/day as a potential male hormonal contraceptive. A dosage of as low as 5 ... A way to avoid the heavy progestogen overdosage inherent with the high-dose reverse sequential therapy would be to combine the ... Rabe T, Kowald A, Ortmann J, Rehberger-Schneider S (August 2000). "Inhibition of skin 5 alpha-reductase by oral contraceptive ... Wang C, Yeung KK (March 1980). "Use of low-dosage oral cyproterone acetate as a male contraceptive". Contraception. 21 (3): 245 ...
Pharmacodynamics of progesterone
Early studies on its use as an oral contraceptive showed that, at 300 mg/day (5th to 25th day of the menstrual cycle), ... "Relationship between allopregnanolone and negative mood in postmenopausal women taking sequential hormone replacement therapy ... The ovulation-inhibiting (i.e., contraceptive) dosage of oral crystalline (non-micronized) progesterone in women is 300 mg/day ... The efficacy of progesterone as an oral contraceptive was never fully tested, because synthetic progestational agents, which ...
Even after [...] Harry W. Rudel; Fred A. Kinel (September 1972). "Oral Contraceptives. Human Fertility Studies and Side Effects ... OHPA (100 mg) was reportedly marketed in combination with mestranol (80 μg) as a sequential combined birth control pill under ... Goebelsmann U (1986). "Pharmacokinetics of Contraceptive Steroids in Humans". In Gregoire AT, Blye RP (eds.). Contraceptive ... OHPA was found to possess two to three times the oral activity of 17α-methylprogesterone. Upjohn reported the oral activity of ...
Identified as one of the simple forms of oral literature by the Dutch linguist André Jolles [de], jokes are passed along ... In a study of conversation analysis, the sociologist Harvey Sacks describes in detail the sequential organisation in the ... Contraceptive pills were first approved for use in the United States in 1960. ... Identified as one of the "simple forms" of oral literature by André Jolles [de] in 1930, they have been collected and ...
... oral contraceptives and other estrogens, sympathomimetics, and thyroid hormones. Sulfonylureas tend to interact with a wide ... a Cochrane systematic review and meta-analysis of randomized clinical trials and trial sequential analysis". CMAJ Open. 2 (3): ... A Meta-Analysis with Trial Sequential Analysis of Randomized Clinical Trials". PLoS Medicine. 13 (6): e1002091. doi:10.1371/ ...
Side effects of cyproterone acetate
"Oral contraceptives and liver cancer. Results of the Multicentre International Liver Tumor Study (MILTS)". Contraception. 56 (5 ... "Toxic hepatitis after sequential administration of flutamide and cyproterone acetate". Dig. Dis. Sci. 49 (3): 462-5. doi: ... 8.2% for 3 mg/day oral diethylstilbestrol (n = 269); and 4.5% for 300 mg/day oral CPA vs. 0% for 750 mg/day flutamide (n = 264 ... 4.2% for 100 mg/month intramuscular estradiol undecylate (n = 191); 2.4% for 250 mg/day oral CPA vs. 6.1% for 200 mg/day oral ...
Arowojolu AO, Gallo MF, Lopez LM, Grimes DA (July 2012). Arowojolu AO (ed.). "Combined oral contraceptive pills for treatment ... It is used in menopausal hormone therapy under the brand name Climen, which is a sequential preparation that contains 2 mg ... Beylot C, Doutre MS, Beylot-Barry M (1998). "Oral contraceptives and cyproterone acetate in female acne treatment". Dermatology ... Fruzzetti F, Bitzer J (2010). "Review of clinical experience with estradiol in combined oral contraceptives". Contraception. 81 ...
Gonadotropin surge-attenuating factor
Superovulation is common in women who take medications such as clomiphene citrate, an anti-estrogenic oral medication used to ... GnSAF could form part of a contraceptive drug or in treatments for infertility that target LH hypersecretion or abnormal ... "Endogenous Luteinizing Hormone Surge during Superovulation Induction with Sequential Use of Clomiphene Citrate and Pulsatile ...
Luque-Ramírez M, Nattero-Chávez L, Ortiz Flores AE, Escobar-Morreale HF (March 2018). "Combined oral contraceptives and/or ... a Cochrane systematic review and meta-analysis of randomized clinical trials and trial sequential analysis". CMAJ Open. 2 (3): ... Metformin has an oral bioavailability of 50-60% under fasting conditions, and is absorbed slowly. Peak plasma concentrations ( ... Jia Y, Lao Y, Zhu H, Li N, Leung SW (January 2019). "Is metformin still the most efficacious first-line oral hypoglycaemic drug ...
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It is spread by transfer from the oral/nasal secretions of an infected individual to the oral cavity of an uninfected ... intrauterine contraceptive devices, metallic implants, surgical mesh), skin ulcers, and venous ulcers. Signs and symptoms of ... in Japan suggest that patients diagnosed with CAEBV be treated early in their disease with an intensive 3 step sequential ... Once in the oral cavity, the virus invades, reproduces in, establishes its lytic phase in, and lyses (i.e. bursts open) ...
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Contraceptive Agents. Ethinyl Estradiol-Norgestrel Combination. Contraceptives, Oral. Contraceptives, Oral, Sequential. ... Contraceptive Agents, Female. Contraceptives, Oral, Combined. Contraceptives, Oral, Synthetic. Contraceptives, Postcoital, ... Randomized Study to Investigate the Impact of a Sequential Oral Contraceptive (SH T00658ID) as Compared to a Sequential Oral ... Metabolism Study to Investigate the Impact of a Sequential Oral Contraceptive. The safety and scientific validity of this study ...
Pharmacodynamics of NPC-01/IKH-01; Effect of NPC-01/IKH-01 on Sexual Hormone Concentrations in Healthy Female Volunteers - Full...
October 1969 - Volume 34 - Issue 4 : Obstetrics & Gynecology
Effects of a Sequential Oral Contraceptive on Endocervical Carbohydrate Histochemistry. KELLETT, WILLIAM W.; HESTER, LAWRENCE L ... Plasma Lipid and Lipoprotein Alterations During Oral Contraceptive Administration. SACHS, BERNARD A.; WOLFMAN, LILA; HERZIG, ... Oral Progestins and Regression of Carcinoma In Situ and Cervical Dysplasia: A Cytologic Evaluation. AYRE, J ERNEST; REYNER, ...
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Oral contraceptives which owe their effectiveness to hormonal preparations. MeSH. Contraceptives, Oral, Sequential (3) • Drugs ... Contraceptive Effect (0) see Contraceptive Agents. Contraceptives, Oral (42) • Compounds, usually hormonal, taken orally in ... Contraceptives, Oral, Synthetic (28) • Oral contraceptives which owe their effectiveness to synthetic preparations. MeSH ... Contraceptives, Oral, Combined (17) • Fixed drug combinations administered orally for contraceptive purposes. MeSH ...
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... did not use oral contraceptives or hormone therapy; and were postmenopausal at recruitment. Mediating pathways from adiposity ... Adiposity and Endometrial Cancer Risk in Postmenopausal Women: A Sequential Causal Mediation Analysis. S. Ghazaleh Dashti, ... Adiposity and Endometrial Cancer Risk in Postmenopausal Women: A Sequential Causal Mediation Analysis ... Adiposity and Endometrial Cancer Risk in Postmenopausal Women: A Sequential Causal Mediation Analysis ...
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It was formerly used as the progestational component in oral sequential contraceptives. ... 01/01/1980 - " Cases of endometrial cancer have been observed in women using sequential oral contraceptives, particularly ... It was formerly used as the progestational component in oral sequential contraceptives. ... Silverberg and Makowski reported several cases of endometrial carcinoma associated with the use of the sequential OC Oracon, a ...
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... sequential oral contraceptives; COC, combined oral contraceptives; POC, progestrogen only oral contraceptives; ERT, estrogen ... There are three types of oral contraceptives: SOC, COC, and POC. SOC formulations include estrogen only pills (for up to 16 ... Weiderpass E., Adami H. O., Baron J. A., Magnusson C., Lindgren A., Persson I. Use of oral contraceptives and endometrial ... In addition, the greater risk in women using SOC may be explained by the fact that oral estrogens block ovulation and ovarian ...
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Use of hormonal oral contraceptives for acne control for less than 6 months prior to the randomisation. ... Efficacy and the Tolerability of the Sequential Application of Two Marketed Products in Patients With Acne Vulgaris. The safety ... The aim of this proof of principle study is to evaluate efficacy and safety of the sequential application of two marketed ... Exploratory Study Evaluating the Efficacy and the Tolerability of the Sequential Application of Two Marketed Products in ...
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Modified sequential oral contraceptive US4544554A (en) * 1983-09-26. 1985-10-01. Ortho Pharmaceutical Corporation. Triphasic ... Modified sequential oral contraceptive US4544554A (en) * 1983-09-26. 1985-10-01. Ortho Pharmaceutical Corporation. Triphasic ... Pharmaceutical suspension for oral administration US6962908B2 (en) 2001-12-21. 2005-11-08. Warner Chilcott Company Inc.. Oral ... oral contraceptive EP0179703A1 (en) * 1984-10-03. 1986-04-30. Roquette Frères. Granular mannitol for direct compression and ...
A Phase II Study of Neoadjuvant Lapatinib plus Chemotherapy (Sequential FEC75 and Paclitaxel) in Women with Inflammatory Breast...
13) Any intrauterine device (IUD) with a documented failure rate of less than 1% per year; oral contraceptives (either combined ... 8) Are able to swallow and retain oral medication (intact pill).. 9) Are able to complete all screening assessments as outlined ... A Phase II Study of Neoadjuvant Lapatinib plus Chemotherapy (Sequential FEC75 and Paclitaxel) in Women with Inflammatory Breast ...
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In recent years the use of the oral contraceptive preparations has provoked a considerable amount of discussion in the medical ... Goldzieher, J. W., Becerra, C., Gual, C. et al. (1964). New oral contraceptive sequential estrogen and progestin. Amer. J. ... Combined Oral Contraceptives. A Statement by the Committee on Safety of Drugs (1970). Brit. med. J. 2, 231.CrossRefGoogle ... Mears, E. and Grant, E. C. G. (1962). "Anovlar" as an oral contraceptive. Brit. med. J. 2, 75.CrossRefGoogle Scholar ...
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Pyorala, K., Pyorala, T., and Lempinen, V.: Sequential oral contraceptive treatment and intravenous glucose tolerance. The ... Wynn, V., Doar, J.W.H., and Mills, G.L.: Some effects of oral contraceptives on serum-lipid and lipoprotein levels. The Lancet ... Spellacy, W.N., Buhi, W.C., Moses, L.C., and Goldzieher, J.W.: Carbohydrate studies in long-term users of oral contraceptives. ... di Paola, G., Pucholo, F., Robin, M., Nicholson, R., and Marti, M.: Oral contraceptives and carbohydrate metabolism. Am. J. Ob ...
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Lower esophageal sphincter pressure in women using sequential oral contraceptives. Van Thiel, D.H., Gavaler, J.S., Stremple, J ... Gallbladder function in the human female: effect of the ovulatory cycle, pregnancy, and contraceptive steroids. Everson, G.T., ... may be one reason for the increased risk of cholesterol cholelithiasis in pregnant women and in those taking contraceptive ...
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What is Contraceptives, oral? Meaning of Contraceptives, oral medical term. What does Contraceptives, oral mean? ... oral in the Medical Dictionary? Contraceptives, oral explanation free. ... Gynecology A preparation of synthetic hormones intended to make a ♀ inconceivable by inhibiting ovulation OC formats Sequential ... Contraceptives, Monophase contraceptive, Third-generation contraceptive, Triphasic contraceptive. Oral contraceptives, ...
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A positive association of sequential oral contraceptives and adenocarcinoma of the endometrium has been suggested. However, a ... The possibility that oral contraceptives may be associated with other types of neoplasia remains under close scrutiny. ... In the light of the data now available it has become increasingly necessary for oral contraceptive therapy to be under regular ... The oestrogenicity of an oral contraceptive seems to determine its propensity to induce thromboembolic disease and this may be ...
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The risk associated with the use of other sequential oral contraceptives remains unclear, mainly because these drugs are no ... It was introduced in the United States as an oral contraceptive in combination with high doses of ethinylestradiol under the ... Secrosteron a new oral progestational substance British Drug Houses (South Africa) (Pty.) Ltd., announce the introduction of ... It is the purpose of this paper to introduce and describe a new steroid for oral administration, 17-a-hydroxyprogesterone ...
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An Evaluation of the Pharmacokinetics of an Oral Contraceptive (Brevicon) When Co-administered With Albiglutide . ... This Phase I, open-label, sequential, single-center study evaluates the pharmacokinetics of digoxin when coadministered with ... pharmacokinetics and pharmacodynamics of a standard oral contraceptive regimen (Brevicon). The primary o... ...
Abbreviations that start with S - AskDocWeb.com
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- 1964). New oral contraceptive sequential estrogen and progestin. (springer.com)
- Progestin-only oral contraceptives generally do not block ovulation. (thefreedictionary.com)
- The relative risk of endometrial cancer for women who had used combined oral contraceptives containing both an estrogen and a progestin was 0.5 (95% confidence limits 0.4-0.8). (cdc.gov)
- By contrast, women who had used sequential oral contraceptives (estrogen and progestin components taken at different times of the month) appeared to have an increased risk of endometrial cancer. (cdc.gov)
- The study used population-based cancer registries in eight geographic regions across the United States showed that women who had used sequential oral contraceptives (estrogen and progestin components taken at different times of the month) appeared to have an increased risk of endometrial cancer. (selfgrowth.com)
- Among women using the then "low dosage" progestin oral contraceptives, the study found no difference in the prevalence of positive serum CRP between this class of OC users versus nonusers. (bio-medicine.org)
- Because of their effectiveness and good patient acceptability, the oral progestin/estrogen combinations are the most widely used steroidal formulations for contraception. (glowm.com)
- To negate the excess risk of endometrial hyperstimulation, an adequate progestin dose must be given in a continuous combined regimen or for an appropriate number of days in sequential regimens (10 days or more for some progestogens or 12 days or more for other progestogens). (unboundmedicine.com)
- Progestin-only contraceptives administered by injection (Depo-Provera) or subcutaneous implant (Norplant) have been available to U.S. women for about a decade. (diabetesjournals.org)
- For diabetic women free of microvascular or macrovascular disease, the World Health Organization (WHO) acknowledges that progestin-only contraceptives in general (i.e., progestin-only pills as well as injections and implants) may slightly influence carbohydrate metabolism, but the WHO also indicates that the advantages of DMPA or LNG implants generally outweigh their theoretical or proven risks ( 6 ). (diabetesjournals.org)
- The American College of Obstetricians and Gynecologists has stated that among diabetic women who have vascular disease or are older than 35 years, the use of progestin-only oral contraceptives, DMPA, or implants may be safer than combination (i.e., estrogen plus progestin) oral contraceptives ( 7 ). (diabetesjournals.org)
- Use of low-dose oral contraceptive pills in women over 35 years of age provides protection against unwanted pregnancy, maintains a stable hormonal environment and decreases abnormal menstrual bleeding. (aafp.org)
- Data from several studies suggest that perimenopausal administration of low-dose oral contraceptive pills can help prevent the acceleration of bone turnover and substantially reverse the decreasing bone density and resultant osteoporosis that occur during the menopausal years. (aafp.org)
- BACKGROUND OF THE INVENTION Press-through packs or blister packs are commonly used today to package units of medication or pills for oral ingestion. (google.es)
- To assess the effects of clomiphene citrate (CC) and combined oral contraceptive pills (COP) on endometrial pinopode expression. (bioline.org.br)
- Tese changes occur rapidly and hence lamotrigine levels rise during Withdrawal of carbamazepine in seizure-free male and female the pill-free week if sequential pills are used . (penosil.com)
- Randomized clinical trial evaluating metformin versus oral contraceptive pills in the treatment of adolescents with polycystic ovarian syndrome. (rchsd.org)
- and to study the changes in lipid profile after 3 months use of sequential hormone therapy and with low dose estrogen combination pills. (bvsalud.org)
- Conclusion: There is substantial degree of metabolic changes in lipid lipoprotein profile in females with use of sequential hormones .With use of low dose estrogen and progesterone pills, there is no such deleterious effect on lipid profile and so it can be used for prolonged period. (bvsalud.org)
- It is important to consider that not all estrogens and progestins are used with the same dosage, route of administration (oral, transdermal and for estradiol intranasal) and, mostly, different estrogens do not show the same bioavailability and tissue effects. (unboundmedicine.com)
- For example, the sequential oral contraceptives and estrogens used in the menopause increase the risk of uterine body and breast cancer. (blogspot.com)
- 6. A contraceptive therapy unit adapted for administration in an extended contraceptive regimen, said unit comprising a sufficient number of transdermal patches to provide at least 42 consecutive days of contraceptive therapy, wherein each transdermal patch comprises a suitable matrix and a combination of ethinyl estradiol and norelgestromin, and wherein said regimen provides enhanced bleeding control and enhanced continuation and satisfaction rates in menstruating females using said regimen. (freepatentsonline.com)
- This study will be an open-label study to evaluate the effect of albiglutide on the pharmacokinetics and pharmacodynamics of a standard oral contraceptive regimen (Brevicon). (bioportfolio.com)
- Daily oral administration of one capsule BAY86-5027 [estradiol valerate (EV) / dienogest (DNG)] for 28 days per cycle in the sequential 4-phasic regimen for 6 treatment cycles. (clinicaltrials.gov)
- Sequential 4-phasic regimen. (clinicaltrials.gov)
- This is dramatically reduced by the addition of progestogen to the regimen, but cyclical progestogen as part of a sequential HRT regimen does not completely eliminate the risk of carcinoma. (bmj.com)
- The present invention is concerned with a kit containing a plurality of hormone units for use in a contraceptive method which consists of two alternating consecutive phases, sometimes referred to as a sequential method or sequential regimen. (google.com)
- 1. A method of contraception comprising the step of: administering to a menstruating female a cycle of contraceptive therapy, each cycle of therapy including the transdermal administration of a combination of ethinyl estradiol and norelgestromin for at least 42 successive days, wherein said method provides enhanced bleeding control and enhanced continuation and satisfaction rates in menstruating females using said method. (freepatentsonline.com)
- Studies have shown that women who used Oracon, a sequential preparation that employed dimethisterone (weak progestogen) with a large dose of a potent estrogen (ethinyl estradiol), had substantially elevated risks of uterine cancer (6,21). (wikipedia.org)
- This study evaluated the effect of the herbal remedy St. John's Wort on oral contraceptive (OC) therapy with respect to the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding. (nih.gov)
- No significant differences were found between the reference groups and the ones taking oral contraceptives with oestrogenic concentrations of 0.05 mg or 0.03 mg ethinyl oestradiol for more than one year. (tudelft.nl)
- This article discusses potential risks of oral contraceptive use in this age group, as well as recommendations about when and how to change from contraceptive therapy to postmenopausal hormone replacement therapy. (aafp.org)
- 8 The largest investigation to date, the Cancer and Steroid Hormone Study (CASH), showed a decrease averaging 40 percent in the development of ovarian cancer in women who had taken oral contraceptives. (aafp.org)
- oral hormone medication for contraception. (thefreedictionary.com)
- Overall, common hormonal factors including oral contraceptive and hormone replacement therapy did not alter the risk of thyroid cancer. (hindawi.com)
- It has been demonstrated that the secretion of thyroid stimulating hormone (TSH) increased during puberty, pregnancy, and oral contraceptive use [ 6 ]. (hindawi.com)
- Many epidemiological studies have investigated roles of hormonal and reproductive factors in the development of thyroid cancer, for instance, oral contraceptive use, hormone replacement therapy, menstrual factors, and fertility status [ 8 - 32 ]. (hindawi.com)
- The dosage forms containing a combination of 17 β-estradiol and progesterone are particularly useful as contraceptives, while the dosage forms containing only one of the hormonal components find utility in the treatment of conditions such as menopause, menstrual disorders, etc., which are known to respond to administration of a natural or synthetic female hormone. (google.com)
- Risk factors for VTE include hospitalization for surgical or medical illness, cancer, trauma or immobilization, medications, such as oral contraceptives or hormone replacement therapy, and pregnancy or postpartum. (cochrane.org)
- This invention relates to a new method for preparing solid pharmaceutical compositions for oral administration of low-dose medications whose active ingredients have steroidal or steroid-like structures. (google.com)
- Thromboembolic disease and the steroidal content of oral contraceptives. (springer.com)
- The protective effect of oral contraceptive use persisted more than 10 years after pill use was discontinued. (cdc.gov)
- 1 A number of physicians and researchers have claimed that the birth control pill (BCP) (also called an oral contraceptive ) is actually an abortifacient. (onemoresoul.com)
- In contrast, prolonged sei- trigine, the combined contraceptive pill can be used with tricycling zure activity, such as status epilepticus, may be a serious threat to or continuous use to avoid fuctuations in lamotrigine serum con- the fetus as well as to the woman. (penosil.com)
- Group B: 20 females were subjected to combined oral contraceptive pill "Mala N". Results: In Group A there was significant rise in serum cholesterol, serum TGs ,LDL, VLDL levels and LDL:HDL ratio. (bvsalud.org)
- d. 21 March 1978 in Hobe Sound, Florida), pharmaceutical manufacturer with G. D. Searle, Inc., the company that developed the first effective and inexpensive oral contraceptive ("the Pill") for women in 1957, which was integral to the 1960s sexual revolution. (encyclopedia.com)
- The sequential dosage was first marketed in 1957 under the trade name Enovid, packaged in a round plastic tray so that the proper pill would be taken during each day of a menstrual cycle. (encyclopedia.com)
- Menopausal symptoms, such as hot flushes, night sweats and vaginal dryness can be relieved by oestrogen replacement, such as sequential HRT or oral contraceptive pill. (femelife.com)
- Relation of arterioles in the endometrium to headache from oral contraceptives. (springer.com)
- A positive association of sequential oral contraceptives and adenocarcinoma of the endometrium has been suggested. (ovid.com)
- Historically, the dose of a progestogen that produced secretory changes in the estrogen-primed endometrium was the one used in the first clinical contraceptive studies of that agent. (glowm.com)
- Continuous combined HRT is not associated with the development of hyperplasia or carcinoma, and may normalise the endometrium of women who have developed complex hyperplasia on sequential HRT. (bmj.com)
- It was introduced in the United States as an oral contraceptive in combination with high doses of ethinylestradiol under the brand name Oracon (25 mg dimethisterone, 100 μg ethinylestradiol) in 1965. (wikipedia.org)
- Daily oral administration of one capsule ethinylestradiol (EE) / levonorgestrel (LNG) for 21 days, followed by 1 capsule placebo for 7 days (28 days total per cycle) for 6 treatment cycles. (clinicaltrials.gov)
- Various side effects have been described and these have been in the main attributed to the oestrogen content of these preparations and, in particular, an increase in the incidence of venous and arterial thromboembolism in women taking oral contraceptives. (springer.com)
- Monthly sequential HRT comprises continuous oestrogen with progestogen added for 10-14 days/cycle or calendar month, producing monthly withdrawal bleeding. (bmj.com)
- Long term use of oral contraceptives containing high doses of oestrogen and progesterone increase the risk of this cancer. (wcrf.org)
- 0002] The present invention relates to extended cycle contraceptive regimens for menstruating females. (freepatentsonline.com)
- More particularly, the present invention relates to extended cycle contraceptive regimens containing a potent sulfatase inhibiting progestogen, such as, norgestimate (NGM) or norelgestromin (NGMN), and an estrogen. (freepatentsonline.com)
- There are two commonly used regimens, sequential (cyclic) and continuous combined. (bmj.com)
- Sequential comparisons of one-month and three-month depot leuprolide regimens in central precocious puberty. (rchsd.org)
- oral contraceptive a compound, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. (thefreedictionary.com)
- The pregnancy rate when oral contraceptives are used correctly is less than 0.2% a year. (thefreedictionary.com)
- Oral contraceptives are second after sterilization in effectiveness in avoiding pregnancy. (thefreedictionary.com)
- Similarly, there was no evidence of an increased risk of breast cancer for women who used oral contraceptives before their first pregnancy. (cdc.gov)
- A variety of acute and chronic risk factors, including surgery, pregnancy and some oral contraceptives, serious illnesses and immobility are associated with inappropriate blood clot (thrombus) formation in veins - especially in the legs. (labtestsonline.org.uk)
- Contraceptive measures are methods used to prevent conception (pregnancy).They include all temporary and permanent measures to prevent pregnancy resulting from coitus (sexual intercourse). (drajay.co.in)
- The 17-acetoxy compounds are used only in injectable contraceptives. (glowm.com)
- A systematic review has examined the differences between two progestogen-only injectable contraceptives, depot medroxyprogesterone acetate (DMPA) and norethisterone oenanthate (NET-EN) (1). (who.int)
- Additional research could help clarify whether exposure to injectable or implantable contraceptives leads to increased risk of type 2 diabetes and gestational diabetes in women with predisposing factors. (diabetesjournals.org)
- Few guidelines exist for the use of estrogen, particularly low-dose oral contraceptives, during the perimenopausal years. (aafp.org)
- In addition to adequate calcium supplementation and weight-bearing exercise, the use of low-dose oral contraceptives appears to be associated with a significant increase in bone density. (aafp.org)
- Another benefit of low-dose oral contraceptive use during the perimenopausal years is a reduction in the risk of endometrial cancer. (aafp.org)
- Changes in circulating lipoproteins, which may be related to the risk for atherosclerotic vascular disease, were studied in a control group and in two groups of 24 or 26 women using different preparations of low-dose oral contraceptives for 3 months. (tudelft.nl)
- Sixteen healthy women were treated with a low-dose OC (Loestrin 1/20) and a placebo for two consecutive 28-day cycles in a single-blind sequential trial. (nih.gov)
- Treatment with St. John's Wort was associated with a significant 13-15% reduction in the dose exposure from the contraceptive. (nih.gov)
- Given the current availability of the high sensitivity CRP test, it is possible to assess the effects of current low dose oral contraceptives on this biomarker for cardiovascular disease risk. (bio-medicine.org)
- At that point, the estrogen dose was increased until the product became clinically acceptable, that is, in terms of contraceptive efficacy and regulation of bleeding. (glowm.com)
- It later became apparent that these levels of estrogen were unnecessarily high when it was learned that the progestogen dose alone provided a fully contraceptive effect. (glowm.com)
- Only evidence from randomized controlled trials (RCTs) in which DMPA was given at a dose of 150mg every 3 months and NET-EN at a dose of 200mg every 2 months were included. (who.int)
- In a study with 14 C-tolterodine solution in healthy volunteers who received a 5 mg oral dose, at least 77% of the radiolabeled dose was absorbed. (nih.gov)
- Individual plasma dapivirine concentrations did not exceed 553 pg/mL and were well below plasma concentrations at the maximum tolerated dose for oral treatment (mean Cmax 2286 ng/mL). (omicsonline.org)
- Initially, studying glucose tolerance in women treated with contraceptive steroids seemed to be a logical way to dissociate the effects of gonadal steroids from the metabolic effects of human placental lactogen during gestation. (springer.com)
- Recent studies have indicated that the risk of developing ovarian cancer is reduced in women who have used oral contraceptives compared with women who have never used them. (aafp.org)
- The CASH study reported that after 12 to 23 months of oral contraceptive use, the age-adjusted risk of developing endometrial cancer was 40 percent less than the risk in women who have never used oral contraceptives. (aafp.org)
- Most oral contraceptives must be taken by women. (thefreedictionary.com)
- Risk attributable to oral contraceptives is very small among non-smokers but there are certain categories, notably women with thrombophilia from genetic mutations, in which the risk is slightly increased. (thefreedictionary.com)
- Hypertension develops more frequently in women on oral contraceptives than in an otherwise comparable group who are not taking them, and although generally of a modest degree, may at times be of disastrous severity. (ovid.com)
- A predilection for development of hyperlipidaemia by patients with types IV or V lipoprotein patterns may contraindicate use of combined oral contraceptives in such women. (ovid.com)
- An initial analysis of an ongoing, multicenter case-control study indicates that women who have used oral contraceptives are approximately half as likely to develop ovarian and endometrial cancer as women who have never used them and that, despite previous concerns, contraceptive use does not appear to increase a woman's risk of breast cancer. (cdc.gov)
- The relative risk of ovarian cancer for women who had used oral contraceptives for at least 1 month, as compared with women who had never used them, was 0.6 (95% confidence limits 0.4-0.9). (cdc.gov)
- The protective effects of combined oral contraceptives against endometrial cancer appeared to be restricted to women who had used them for 1 year or longer and was concentrated in nulliparous women. (cdc.gov)
- For breast cancer, women who had used oral contraceptives had a relative risk of 0.9 (95% confidence limits 0.8-1.2) compared with women who had never used them. (cdc.gov)
- Furthermore, there was no indication of any increased risk of breast cancer due to oral contraceptive use for high-risk women such as those with family histories of breast cancer or with previous biopsies for benign breast disease. (cdc.gov)
- Women using OCs should be cautioned that St. John's Wort might interfere with contraceptive effectiveness. (nih.gov)
- That study reported the presence of CRP in more than half of women using first generation combined or sequential oral contraceptives of the 1960s. (bio-medicine.org)
- Women on oral contraception had lower ERα (p = 0.048) and PR (p = 0.007) levels than women in the follicular phase. (diva-portal.org)
- Protein levels of the androgen receptor, syndecan-4 and decorin was lower in premenopausal women who were using oral contraceptives (OC) than in those in the follicular phase (p = 0.002 - 0.02), whereas no significant differences between OC use and the luteal phase were found. (diva-portal.org)
- This group of twelve adults comprised of six men and six women, three of whom were on oral contraceptives (OC+). (sages.org)
- ABSTRACT Women with chronic medical conditions require careful contraceptive management. (who.int)
- The aim of the study is to investigate whether women on oral contraceptives (OCs) suffering from acquired OC-associated female sexual dysfunction (FSD) for at least 3 months but no longer than one year will express the same level of sexual distress when taking SH T00658ID compared to Microgynon, the usual OC prescribed for women with OC-associated FSD. (clinicaltrials.gov)
- DMPA and NET-EN are similar in terms of their efficacy and safety, except that more women using DMPA experience amenorrhoea. (who.int)
- This study had recruited 10331 women, but data from a third arm (in which NET-EN was given every 2 months for 6 doses and every 3 months thereafter) were excluded. (who.int)
- Most endometrial biopsies from women on sequential HRT show weak secretory features. (bmj.com)
- The temporal overlap of a diabetes increase among young women and availability of new contraceptive methods has stimulated us to review the published literature on insulin-glucose metabolism in the presence of these hormonal agents. (diabetesjournals.org)
- RESULTS -After adjusting for age, BMI, and oral contraceptive use, BMD at year 2 continued to be lower in women ≥20 years of age with type 1 diabetes compared with control subjects at the total hip, femoral neck, and whole body. (diabetesjournals.org)
- Women on hormonal contraceptives can experience breakthrough bleeding and/or withdrawal bleeding. (wikipedia.org)
- This trial assessed the safety and pharmacokinetic aspects of the Dapivirine Vaginal Ring-004 when worn as multiple rings over sequential periods of ring use by healthy, sexually-active, HIV-negative women. (omicsonline.org)
- The company's fortune rested, however, on developing the first effective and inexpensive oral contraceptive for women. (encyclopedia.com)
- RÉSUMÉ Les femmes atteintes d'affections médicales chroniques ont besoin d'une prise en charge prudente de leur contraception. (who.int)
- 1. A pharmaceutically acceptable nasal composition, in dosage unit form, for nasal administration to a female mammal for the purpose of mammalian contraception, said composition consisting essentially of, per nasal unit, a systemically effective contraceptive amount of a combination of progesterone and a pharmaceutically acceptable, estrogenically active form of 17β-estradiol, together with a nontoxic pharmaceutically acceptable nasal carrier therefor, said composition comprising a nasal ointment or a nasal gel. (google.com)
- Typical monophasic Oral Contraceptive used in seasonal Contraception (e.g. (fpnotebook.com)
- In recent years the use of the oral contraceptive preparations has provoked a considerable amount of discussion in the medical literature along with a vigorous reaction in the lay Press. (springer.com)
- Sequential preparations in which unopposed estrogen is given in the first part of the cycle have been discontinued in many parts of the world. (glowm.com)
- The web-based Tutorial and Practice Test Items on USMLE website include single multiple-choice questions, a sequential set of multiple-choice questions, a scientific abstract (a summary of an experiment or clinical investigation, accompanied by two or more questions), and items with audio or video findings. (usmle.org)
- Gynecology A preparation of synthetic hormones intended to make a ♀ inconceivable by inhibiting ovulation OC formats Sequential method, combined method. (thefreedictionary.com)
- Dimethisterone, also known as 6α,21-dimethylethisterone or as 6α,21-dimethyl-17α-ethynyltestosterone, as well as 17α-ethynyl-6α,21-dimethylandrost-4-en-17β-ol-3-one or as 6α,21-dimethyl-17β-hydroxy-17α-pregn-4-en-20-yn-3-one, is a synthetic androstane steroid and a derivative of testosterone. (wikipedia.org)
- Searle then developed a sequential dosage of estrogen, followed by a dosage of combined estrogen and progestrogen. (encyclopedia.com)
- The three studies that performed sequential intravenous glucose tolerance tests (IVGTTs) on injection users all found an increased early-phase insulin response. (diabetesjournals.org)
- 11 With three monthly sequential HRT, progestogen is given quarterly for 10-14 days, producing quarterly withdrawal bleeding. (bmj.com)
- This is the first case report of sequential cancers (endometrial and breast) in a patient with a BRCA2 mutation among a Korean population. (ogscience.org)
- In the shorter (1-year) single site study, 27% of DMPA users and 40% of NET-EN users were lost to follow up. (who.int)
- Both DMPA and NET-EN are extensively used in developing countries, but may be priced very differently. (who.int)
- Based on data from the Management Sciences for Health International Drug price Indicator Guide 2005, the acquisition cost per couple-year of protection in Namibia was $6.0056 for DMPA and $6.2094 for NET-EN (4). (who.int)
- Both DMPA and NET-EN appear on the core list of the WHO Model Essential Medicines List (14th edition)(5). (who.int)
- The DMPA injection must be repeated every 3 months for continuing contraceptive benefit. (diabetesjournals.org)
- however, Silverberg and Makowski reported several cases of endometrial carcinoma associated with the use of the sequential OC Oracon, a product containing dimethisterone. (curehunter.com)
- The oestrogenicity of an oral contraceptive seems to determine its propensity to induce thromboembolic disease and this may be substantially or even preponderantly contributed to by the progestagen component. (ovid.com)
- Taken to- Estradiol-containing oral contraceptives induce the elimination of gether, these observations confrm that valproic acid can indeed lamotrigine. (penosil.com)
- Background:Oral contraceptives can induce changes in lipid, lipoprotein and carbohydrate metabolism. (bvsalud.org)
- Junge W, Mellinger U, Parke S, Serrani M. Metabolic and haemostatic effects of estradiol valerate/dienogest, a novel oral contraceptive: a randomized, open-label, single-centre study. (clinicaltrials.gov)
- Estrogen doses, however, rather than undergoing proportional decreases, were retained at sufficiently high levels to ensure contraceptive efficacy of the product. (glowm.com)
- Invaded to combination contraceptives, sequential single-agent chemotherapy provides similar efficacy and improved tolerability and may need the vascular option for most patients. (samyenthinhphat.com)
- Oral chemotherapeutic agents, including capecitabine and vinorelbine, have bad significant efficacy in patients with MBC. (samyenthinhphat.com)
- However, a negative association of oral contraceptives with breast cancer incidence seems to suggest some sort of protective effect. (ovid.com)
- There was no evidence that long-term oral contraceptive use of more than 10 years or oral contraceptive use that began 16 or more years ago, shortly after oral contraceptives were introduced in this country, increased the risk of breast cancer. (cdc.gov)
- Combined oral contraceptives are potential risk factors of liver, cervix, and perhaps of breast cancer, although they reduce the incidence of uterine corpus and ovary cancer. (blogspot.com)
- Other noncontraceptive health benefits of oral contraceptives include a reduction in bone loss and protection against iron deficiency anemia, dysmenorrhea, benign breast disease, endometrial cancer and epithelial ovarian cancer. (aafp.org)
- For example, use of oral contraceptives for seven years or longer confers about a 60 to 80 percent reduction in the risk of developing ovarian cancer. (aafp.org)
- The longer a woman had used oral contraceptives, the lower her risk of developing ovarian cancer. (cdc.gov)
- Consistent epidemiological data describe a decreased incidence of ovarian cancer with oral contraceptive use during the reproductive years. (unboundmedicine.com)
- 9 A protective effect has been observed with as little as three to six months of oral contraceptive use, with further decreases in risk seen with longer periods of use. (aafp.org)
- Chemotherapy drug costs cost of cytoxan oral quickly become a financial burden for you and your family. (samyenthinhphat.com)
- Therefore, people often find themselves facing high out-of-pocket costs when filling prescriptions for oral chemotherapy, especially infections! (samyenthinhphat.com)
- Cytoxan, however, cost of cytoxan oral an acceptable chemotherapy drug that can be given by the caregiver at sufficiently in certain cases. (samyenthinhphat.com)
- Association with stroke and with myocardial infarction seems to have been established and where other risk factors for either exist, such as smoking, hyperlipidaemia or hypertension, it would seem wise for other contraceptive measures to be used. (ovid.com)
- See related patient information handout on using oral contraceptives near menopause , written by the authors of this article. (aafp.org)
- Objectives To examine associations between PCa incidence and mortality and population-based use of oral contraceptives (OCs). (bmj.com)
- All other forms of contraceptives (ie, intra-uterine devices, condoms or vaginal barriers) were not correlated with prostate cancer incidence or mortality. (bmj.com)
- Associations between PCa incidence and mortality and population-based use of oral contraceptives (OCs) have been examined. (bmj.com)
- Barrier method of contraceptive prevent the meeting of ovum and sperms after coitus. (drajay.co.in)
- Both of these new contraceptives are highly effective (≤0.3% pregnancies with typical use in the first year [ 5 ]) and require relatively little active involvement from the patient. (diabetesjournals.org)