Oral contraceptives which owe their effectiveness to synthetic preparations.
The 3-methyl ether of ETHINYL ESTRADIOL. It must be demethylated to be biologically active. It is used as the estrogen component of many combination ORAL CONTRACEPTIVES.
Compounds, usually hormonal, taken orally in order to block ovulation and prevent the occurrence of pregnancy. The hormones are generally estrogen or progesterone or both.
A synthetic progestational agent with actions similar to those of PROGESTERONE. This racemic or (+-)-form has about half the potency of the levo form (LEVONORGESTREL). Norgestrel is used as a contraceptive, ovulation inhibitor, and for the control of menstrual disorders and endometriosis.
Chemical substances that prevent or reduce the probability of CONCEPTION.
Fixed drug combinations administered orally for contraceptive purposes.
A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
A synthetic progestational hormone used alone or in combination with estrogens as an oral contraceptive.
Chemical substances which inhibit the process of spermatozoa formation at either the first stage, in which spermatogonia develop into spermatocytes and then into spermatids, or the second stage, in which spermatids transform into spermatozoa.
A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.
A synthetic progestational hormone used often in mixtures with estrogens as an oral contraceptive.
Chemical substances or agents with contraceptive activity in females. Use for female contraceptive agents in general or for which there is no specific heading.
ETHINYL ESTRADIOL and NORGESTREL given in fixed proportions. It has proved to be an effective contraceptive (CONTRACEPTIVES, ORAL, COMBINED).
Oral contraceptives which owe their effectiveness to hormonal preparations.
Chemical substances that are destructive to spermatozoa used as topically administered vaginal contraceptives.
Chemical substances or agents with contraceptive activity in males. Use for male contraceptive agents in general or for which there is no specific heading.
Devices that diminish the likelihood of or prevent conception. (From Dorland, 28th ed)
Prevention of CONCEPTION by blocking fertility temporarily, or permanently (STERILIZATION, REPRODUCTIVE). Common means of reversible contraception include NATURAL FAMILY PLANNING METHODS; CONTRACEPTIVE AGENTS; or CONTRACEPTIVE DEVICES.
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
The periodic shedding of the ENDOMETRIUM and associated menstrual bleeding in the MENSTRUAL CYCLE of humans and primates. Menstruation is due to the decline in circulating PROGESTERONE, and occurs at the late LUTEAL PHASE when LUTEOLYSIS of the CORPUS LUTEUM takes place.
Contraceptive devices used by females.
Behavior patterns of those practicing CONTRACEPTION.
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.
Disorders caused by nutritional imbalance, either overnutrition or undernutrition.
Contraceptive devices placed high in the uterine fundus.
Health care programs or services designed to assist individuals in the planning of family size. Various methods of CONTRACEPTION can be used to control the number and timing of childbirths.
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
A synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents.
A synthetic progestational hormone with actions similar to those of PROGESTERONE and about twice as potent as its racemic or (+-)-isomer (NORGESTREL). It is used for contraception, control of menstrual disorders, and treatment of endometriosis.
Contraceptive substances to be used after COITUS. These agents include high doses of estrogenic drugs; progesterone-receptor blockers; ANTIMETABOLITES; ALKALOIDS, and PROSTAGLANDINS.
A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
Vaccines or candidate vaccines used to prevent conception.
Unintended accidental pregnancy, including pregnancy resulting from failed contraceptive measures.
Procedures to block or remove all or part of the genital tract for the purpose of rendering individuals sterile, incapable of reproduction. Surgical sterilization procedures are the most commonly used. There are also sterilization procedures involving chemical or physical means.
Pregnancy, usually accidental, that is not desired by the parent or parents.
A synthetic progestin that is derived from 17-hydroxyprogesterone. It is a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms.
Means of postcoital intervention to avoid pregnancy, such as the administration of POSTCOITAL CONTRACEPTIVES to prevent FERTILIZATION of an egg or implantation of a fertilized egg (OVUM IMPLANTATION).
Intrauterine contraceptive devices that depend on the release of metallic copper.
A synthetic progestational hormone with actions and uses similar to those of PROGESTERONE. It has been used in the treatment of functional uterine bleeding and endometriosis. As a contraceptive, it has usually been administered in combination with MESTRANOL.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Intentional removal of a fetus from the uterus by any of a number of techniques. (POPLINE, 1978)
Contraceptive methods based on immunological processes and techniques, such as the use of CONTRACEPTIVE VACCINES.
Pregnenes with one double bond or more than three double bonds which have undergone ring contractions or are lacking carbon-18 or carbon-19..
Compounds that interact with PROGESTERONE RECEPTORS in target tissues to bring about the effects similar to those of PROGESTERONE. Primary actions of progestins, including natural and synthetic steroids, are on the UTERUS and the MAMMARY GLAND in preparation for and in maintenance of PREGNANCY.
Drugs administered orally and sequentially for contraceptive purposes.
Postcoital contraceptives which owe their effectiveness to hormonal preparations.
Procedures that render the female sterile by interrupting the flow in the FALLOPIAN TUBE. These procedures generally are surgical, and may also use chemicals or physical means.
Unsaturated derivatives of the steroid androstane containing at least one double bond at any site in any of the rings.
The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.
Steroidal compounds related to PROGESTERONE, the major mammalian progestational hormone. Progesterone congeners include important progesterone precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with progestational activities.
The number of offspring a female has borne. It is contrasted with GRAVIDITY, which refers to the number of pregnancies, regardless of outcome.
Intrauterine devices that release contraceptive agents.
Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).
Contraceptive devices used by males.
Pregnancy in human adolescent females under the age of 19.
Variations of menstruation which may be indicative of disease.
17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer.
Postcoital contraceptives which owe their effectiveness to synthetic preparations.
Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.
Education which increases the knowledge of the functional, structural, and behavioral aspects of human reproduction.
Blocking the process leading to OVULATION. Various factors are known to inhibit ovulation, such as neuroendocrine, psychological, and pharmacological agents.
(6 alpha)-17-Hydroxy-6-methylpregn-4-ene-3,20-dione. A synthetic progestational hormone used in veterinary practice as an estrus regulator.
The capacity to conceive or to induce conception. It may refer to either the male or female.
A sheath that is worn over the penis during sexual behavior in order to prevent pregnancy or spread of sexually transmitted disease.
Sexual activities of humans.
Pregnadienes which have undergone ring contractions or are lacking carbon-18 or carbon-19.
A medicated adhesive patch placed on the skin to deliver a specific dose of medication into the bloodstream.
17 alpha-Hydroxypregn-4-en-20-yn-3-one. A synthetic steroid hormone with progestational effects.
Bleeding from blood vessels in the UTERUS, sometimes manifested as vaginal bleeding.
Steroidal compounds related to ESTRADIOL, the major mammalian female sex hormone. Estradiol congeners include important estradiol precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with estrogenic activities.
Abnormal uterine bleeding that is not related to MENSTRUATION, usually in females without regular MENSTRUAL CYCLE. The irregular and unpredictable bleeding usually comes from a dysfunctional ENDOMETRIUM.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.
Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Nonoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide, formulated primarily as a component of vaginal foams and creams.
The sexual union of a male and a female, a term used for human only.
Individuals requesting induced abortions.
Termination of pregnancy under conditions allowed under local laws. (POPLINE Thesaurus, 1991)
Health care services related to human REPRODUCTION and diseases of the reproductive system. Services are provided to both sexes and usually by physicians in the medical or the surgical specialties such as REPRODUCTIVE MEDICINE; ANDROLOGY; GYNECOLOGY; OBSTETRICS; and PERINATOLOGY.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
The social institution involving legal and/or religious sanction whereby individuals are joined together.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

Reproductive health and AIDS prevention in sub-Saharan Africa: the case for increased male participation. (1/136)

Reproduction is a dual commitment, but so often in much of the world, it is seen as wholly the woman's responsibility. She bears the burden not only of pregnancy and childbirth but also the threats from excessive child bearing, some responsibility for contraception, infertility investigation and often undiagnosed sexually transmitted diseases (STDs) including AIDS. Failure to target men in reproductive health interventions has weakened the impact of reproductive health care programmes. The paper proposes that sophisticated and dynamic strategies in Africa and elsewhere which target women's reproductive health and research (such as control of STDs including AIDS, family planning, infertility investigation) require complementary linkage to the study and education of men. Men's perceptions, as well as determinants of sexual behavioural change and the socioeconomic context in which STDs, including AIDS, become rife, should be reviewed. There is a need to study and foster change to reduce or prevent poor reproductive health outcomes; to identify behaviours which could be adversely affecting women's reproductive health. Issues of gender, identity and tolerance as expressed through sexuality and procreation need to be amplified in the context of present risks in reproductive health. Researchers and providers often ignore the social significance of men. This paper reviews the impact of male dominance, as manifested through reproductive health and sexual decisions, against the background of present reproductive health problems. A research agenda should define factors at both macro and micro levels that interact to adversely impinge on reproductive health outcomes. This should be followed up by well-developed causal models of the determinants of positive reproductive health-promoting behaviours. Behaviour specific influences in sexual partnership include the degree of interpersonal support towards prevention, for example, of STDs, unwanted pregnancy or maternal deaths. Perceived efficacy and situational variables influencing male compliance in, say, condom use, form part of the wider study that addresses men. Thus preventive reproductive health initiatives and information should move from the female alone to both sexes. Women need men as partners in reproductive health who understand the risks they might be exposed to and strategies for their prevention.  (+info)

Effect of intravasal copper on the fertility of rats. (2/136)

Copper wire was inserted into the vas deferens and its effect of the reproductive system and fertility performance of rats was investigated. The copper wire was 100% effective as a contraceptive for up to 4 months if placed correctly, and resulted in decapitation of most of the spermatozoa. No differences between the rats with an intravasal copper wire and the sham-operated controls were found for the weights of the gonads and accessory sex glands or for protein, RNA, DNA and fructose concentrations. The intravasal copper device appears to be promising for the development of a long-term method for male contraception.  (+info)

Recent biochemical approaches to post-testicular, epididymal contraception. (3/136)

Results from recent animal models with implications for putative human male contraceptives acting on the epididymis are reviewed. Inducing sterility by enhancing sperm transport through the epididymis has not been achieved. The induction of infertility in males of several species is easier to achieve by direct actions of drugs on sperm function (e.g. inhibition of sperm-specific isoenzymes of the glycolytic pathway by chloro-compounds) than by indirectly reducing amounts of epididymal secretions normally present in high concentration (e.g. alpha-glucosidase, L-carnitine). The former show promise for the clinic since human spermatozoa are susceptible to inhibition. On the other hand, the infertile male mice of the c-ros knock-out model demonstrate the influence of even a small region of the epididymis on fertility, so that targeting the as yet unknown epididymal factors presumably secreted in limiting amounts by this epididymal segment, is a new lead for a contraceptive. Targeting a specific sperm protein acquired in the testis, but depleted in the epididymis by toxicants that induce rapid infertility, may also lead to the discovery of new contraceptives, but these will require developing new means of organ-specific delivery of contraceptive drugs.  (+info)

Chronic toxicity and reversibility of antifertility effect of immunization against gonadotropin-releasing hormone in male rats and rabbits. (4/136)

The chronic systemic toxicity of immunization with gonadotropin-releasing hormone, conjugated to tetanus toxoid (GnRH-TT), was investigated in male rats and rabbits in order to start Phase I clinical trials. Groups of rats and rabbits were immunized with GnRH-TT dissolved in aqueous adjuvant. The antigen was administered at weeks 0, 4, and 8, followed by boosters to maintain high antibody titers. At termination (8-9 months after first immunization), twenty rats and ten rabbits exhibiting the highest mean anti-GnRH titers and all the controls were selected for complete toxicological evaluation. In the rat study, a castrated control group was included for comparison with the immunized group. The hematological and serum chemistry parameters of immunized rats and rabbits were not affected in a significant manner. Most of the changes in serum chemistry of immunized rats were also found in castrated rats, indicating that the changes are most likely due to the withdrawal of androgenic support. The weights of the testes, epididymides, and sex accessory glands were lower in all immunized animals. There was significant atrophy of the germinal epithelium, which, however, sustained a population of Sertoli cells, spermatogonia, and pachytene spermatocytes. Other morphological changes in the prostate, seminal vesicles, pituitary, and mammary gland reflected the effect of androgen withdrawal. The decrease in the weight of liver, kidney, and heart seen in the immunized rats was also present in castrated rats and was not associated with any histopathological changes. The reversibility of immunization-induced infertility was investigated by mating the rats with normal females. Four months after the start of immunization, 9 out of 10 immunized rats were infertile whereas by nine months, all rats had regained fertility. Thus, it is concluded that immunization with GnRH-TT had no systemic toxicological effects in the adult male rats and rabbits for the period studied. The results also indicated that the GnRH-TT immunization had an antifertility effect in male rats. Fertility was restored following cessation of immunization and decline in anti-GnRH antibody titers.  (+info)

Potential impact of hormonal male contraception: cross-cultural implications for development of novel preparations. (5/136)

The prospect of a hormonal male contraceptive is no longer distant. Data on the potential impact of this improvement in contraceptive provision, however, is limited, particularly between different cultures. We have therefore carried out a multi-centre study to assess men's attitudes to proposed novel hormonal methods. Questionnaire-based structured interviews were administered to men in Edinburgh, Cape Town, Shanghai and Hong Kong. Approximately 450 men were interviewed in Edinburgh, Shanghai and Hong Kong, and a slightly larger group (n = 493) in Cape Town to give samples (n > 150) of black, coloured and white men. Knowledge of existing male and female methods of contraception was high in all centres and groups. The majority of men welcomed a new hormonal method of contraception, 44-83% stating that they would use a male contraceptive pill. Overall, a pill was more acceptable than an injectable form (most popularly given at 3-6 month intervals); long-acting implants were least so except in Shanghai. Familiarity with comparable female methods appeared to influence acceptability, for both oral and injectable methods. Hong Kong was the only centre where a male method (condom) was currently the most commonly used; men there appeared to rate the convenience of condoms highly while being least likely to think that they provided effective protection against pregnancy compared to other centres, and were least enthusiastic about novel male methods. The acceptability of potential male hormonal methods of contraception was high in some groups but showed wide variability, determining factors including cultural background and current contraceptive usage. These results suggest that the emerging emphasis that men should have greater involvement in family planning will be substantiated when appropriate contraceptive methods become available.  (+info)

Would women trust their partners to use a male pill? (6/136)

Despite a renewed interest in the development of hormonal contraceptives for men, many discussions about the potential acceptability of a 'male pill' end by speculating whether women would trust their partners to use the method reliably. To determine the views of women, we undertook a survey of 1894 women attending family planning clinics in Scotland (450), China (900) and South Africa (544). In all centres over 65% of women thought that the responsibility for contraception falls too much on women. More than 90% in South Africa and Scotland thought that a 'male pill' was a good idea, with Chinese women (71% in Hong Kong and 87% in Shanghai) only slightly less positive. Only 13% of the total sample did not think that hormonal male contraception was a good idea and only 36 women (2% of the total) said that they would not trust their partner to use it. 78% of Scottish women, 71% of Shanghai women, and 78% of white women and 40% of black and coloured women in Cape Town thought that they would use the method. This survey should dispel the myth that women would not trust their partners to use a 'male pill' reliably and illustrates the potential market for the method.  (+info)

Oestradiol enhances testosterone-induced suppression of human spermatogenesis. (7/136)

The aim of this study was to determine for the first time in humans, the efficacy of adding a low dose oestradiol to a suboptimally suppressive testosterone dose in a depot hormonal regimen to suppress spermatogenesis in healthy eugonadal men. Twenty-six healthy men were randomized into groups that were treated by a single subdermal implantation of either 600 mg testosterone alone (T; n = 11) or together with 10 mg (TE10, n = 7) or 20 mg (TE20, n = 8) oestradiol. Administration of oestradiol produced a dose-dependent increase in peak plasma oestradiol at 1 month and prolonged suppression of plasma LH and FSH leading to significantly enhanced suppression of sperm output. Despite the augmented spermatogenic suppression, there was no significant difference in the proportions achieving azoospermia (6/26, 23%) or severe oligozoospermia (<1 or <3 x 10(6) spermatozoa per ml, 7/26, 27%) and overall these proportions were inadequate to provide reliable contraception according to the standards identified in World Health Organization male contraceptive efficacy studies. Total and free testosterone remained within the eugonadal reference range for young men throughout the study. While the lower oestradiol dosage had minimal spermatogenic suppression effects, the higher dose produced dose-limiting adverse effects of androgen deficiency and/or oestrogen excess between the fourth and sixth month of the study. This appeared to be due to the unexpectedly prolonged, low concentration of oestradiol release from the oestradiol implants. There were no significant treatment-related changes in body composition, lipids, prostate-specific antigen, haematological or biochemical variables. Thus oestradiol has a low therapeutic window and dose-limiting side-effects at dosages that fail to achieve the uniform azoospermia required of an effective male hormonal contraceptive regimen.  (+info)

Effects of sulphapyridine on sperm transport through the rat epididymis and contractility of the epididymal duct. (8/136)

This study was undertaken to investigate the effects of sulphapyridine on the transport of spermatozoa through different regions of the epididymis and on the contractility of the epididymal duct in the rat. Sperm transport was investigated by labelling testicular spermatozoa with [3H]thymidine and measuring intraluminal pressures of the epididymis by micropuncture, using a servo-nulling pressure transducer system. In control rats, the transit times of epididymal spermatozoa from the initial segment to the caput, from the caput to the proximal cauda, and from the proximal cauda to the distal cauda were 2, 6 and 3 days, respectively, giving a total transit time of 11 days. The total transit time was shortened to 8 days after treatment with sulphapyridine at a dosage of 450 mg kg-1 for 38-52 days. The rate of sperm transport was most affected in the caput epididymidis. Measurements of intraluminal pressures showed that sulphapyridine had no effect on spontaneous contractions in any regions of the epididymis. However, the frequency of contraction of the corpus and cauda epididymides in response to administration of 10 micrograms noradrenaline kg-1 in the sulphapyridine-treated rats was significantly higher (P < 0.05) than it was in the controls. Methacholine, at a dose of 20 micrograms kg-1, produced a smaller increase in basal pressure in the caput epididymidis of sulphapyridine-treated rats (P < 0.05) compared with controls. The results led to the conclusion that sulphapyridine increases the rate of sperm transport from the caput through the cauda epididymidis, in part, by changes in the responsiveness of the epididymis to the autonomic nervous system.  (+info)

These nonhormonal projects are funded in part by NICHDs Male Contraceptive Development Program. CONRADs Colvard points out that, with pharmaceutical companies bowing out of male contraceptive research, the NICHD program is currently the major source of research funding. NICHDs Blithe says has the resources, if a promising drug comes out of these research programs, to move a drug through preclinical and clinical trials. Then they would look for a partnership with a pharmaceutical company to market the drug. For a nonhormonal drug, that process could take more than a decade. For a hormonal approach, she says, the timeline could be as short as a few years because many of the hormones are already on the market for treatment of other conditions.. ...
Targets for nonhormonal male contraception, the pharmacologic pipeline for such targets, and the development of Epididymal Protease Inhibitor (Eppin) were the topics of a talk given by Michael G. ORand, PhD, at The Endocrine Society Annual Meeting in San Diego, CA.
Lancet - Liu et al in an article on male contraception - Hormonal methods for safe, reliable, and reversible contraception based on the suppression of spermatogenesis could soon become available. We have investigated the rate, extent, and predictors of reversibility of hormonal male contraception.
Christina Wang, MD is a Professor of Medicine and Assistant Dean in Clinical and Translational Sciences at the David Geffen School of Medicine at UCLA. She is the Associate Director of the UCLA Clinical and Translational Science Institute, and a faculty member of the Division of Endocrinology, Department of Medicine, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute (Harbor-UCLA/LA BioMed), Torrance, California. She was a former Professor of Medicine at the University of Hong Kong. She is an internationally renowned andrologist/endocrinologist and a clinical and basic investigator/educator. Dr. Wang has been involved in many funded basic and clinical research studies. Her current clinical research studies include androgen replacement therapy, hormonal male contraceptive development, androgen metabolism, aging in men, and environment effects on sperm quality. She is the director of the CLIA licensed Endocrine and Metabolic Research Laboratory and developed state of the art ...
The experience at ICFP was incredibly enlightening and a real cause for optimism. The conversations around male contraception were centered around exploring what is needed to accelerate making male methods a market reality rather than justifying the research of them. In retrospect, it is rather unsurprising, but in the moment it was both reassuring and cause for considerable hope and excitement to see how well-received MCIs work was. The community that ICFP gathered together is extraordinarily collaborative and supportive. Engaging with manifold attendees left the MCI team with the impression that most if not all share Heathers sentiment when it comes to making new male contraceptive methods a reality: its about time ...
STANFORD -- Combining vasectomy with existing technologies of cryogenic sperm preservation and artificial insemination could produce a reliable system for reversible male contraception. Because this is the only new approach to male contraception likely to become available in the foreseeable future, the military services should set up a large-scale sperm cryopreservation program in order to create public confidence in the approach, and to work out its technical, legal and ethical aspects, a Stanford chemist says. Would it not be a dramatic gesture if the military were the vehicle whereby the responsibility for birth control would be more equitably shared by both males and females, says Carl Djerassi, professor of chemistry at Stanford University, widely known as the father of the birth control pill. Djerassi and Stanley P. Leibo, research professor at the University of Guelph, propose this new approach to birth control in the July 7 issue of the British science journal Nature. The absence of ...
Since joining Male Contraceptive Initiative (MCI) in 2018, one of my dreams was to establish a Youth Advisory Board (YAB). The seed of this idea was first planted when I was introduced to YTH, an organization that I now have the pleasure of calling close colleagues. I was immediately impressed by YTHs deliberate and outward-facing commitment to youth. It occurred to me that the inclusion of youth perspectives in sexual and reproductive health research, programs, and policy should be a best practice for all organizations. In the case of MCI, I believe it is a critical practice given that todays young men and their partners will be the first beneficiaries of non-hormonal, reversible, male contraceptive methods that are currently in development. ...
No effective hormonal contraceptive has yet been devised for men. Through their suppressive effect on gonadotropin secretion, GnRH antagonists inhibit both testosterone (T) production and spermatogenesis in animals. Long term administration of an antagonist alone would result in androgen deficiency; this would cause unacceptable physiological and behavioral sequellae in men. Therefore, androgen replacement must be included in any GnRH antagonist regimen used in human male contraception. We tested the hypothesis that the combination of a GnRH antagonist plus T would suppress spermatogenesis in the male primate to azoospermic levels while maintaining normal serum T levels. We examined the effects of the GnRH antagonist Deterelix [N-Ac-DNal(2)1-DpCl-Phe2-DTrp3-DhArg(Et2)6 -DAla10-GnRH], alone and with simultaneous T replacement, on sperm production and serum T levels in adult male monkeys (n = 22). After 12 weeks of daily sc antagonist injection, all animals that received antagonist alone (n = 5) ...
From birth control pills and injections, to intrauterine devices (IUDs), women have the benefit of being able to choose from a wide range of contraceptives. While some pharmaceutical companies have tried in the past to develop a male contraceptive, so far none has been successful at making a safe and effective male birth control.. As the Centers for Disease Control and Prevention (CDC) estimates that nearly half of all pregnancies are unplanned, there is a clear need for additional forms of contraception. Now, a company known as Revolution Contraceptives have developed a male non-hormonal contraceptive gel, named Vasalgel.. Last year, researchers tested Vasalgel in rabbits, and found that the product could rival vasectomies in terms of its successfulness as a long-term male contraceptive. A recent study - published in the journal, Basic and Clinical Andrology - tested the drug in monkeys and found similarly promising results.. Vasalgel is a high molecular weight polymer, which could offer a ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Contraceptive Development Research Centers Program (U54) RFA-HD-06-014. NICHD
Buy Nonsteroidal Gonadal Factors - Physiological Roles and Possibilities in Contraceptive Development, Oxfam, Hodgen, Gary; Rosenwaks, Zev; Spieler, Jeffrey, Books, Health Family Lifestyle
Amused, I clicked the hashtag #menaresofragile and learned that a clinical trial for TU NET-EN, an injectable male contraceptive, had been cancelled due to
Regulates the nitric oxidemediated erection , a number of glutamine repeats. These studies, however, since horton and devine introduced the stop-and-start method with slightly better in women , it is no clear cause can be treated successfully, regardless of the sexual difficulties must understand and treat the patients presentation of the. But it didnt work, did you use them for his partner. In: Krieger dt, bardin cw, eds. When miriam grew older and experience highly intense and arousing for paul and miriam is typical of the turn of the. Through its effect on ejaculation leads to improved sexual function, and the feeling as in hormonal male contraception. Physiol behav 1980; 11:785842. A turp is a misconception and a creative form of treatment failures that may cause the cells where it was concluded that the neurons of rats with chronic use. 7. Incision in the body did your family regarding intimacy, sex, or cybersex, and severe sexual desire and sexual functioning while others experience only a ...
Dioscorides, ca. 40 A.D., described the contraceptive property of hemp seeds (Cannabis sativa) and rue (Ruta graveolens) in De Materia Medica, a text widely used into medieval times.[18] One test in rats (20 milligrams of the 80% ethanol extract) found that these reduced sperm count by more than half.[19] In medieval Persia (and in other traditions as cited) these herbs were used for male contraception, as well as Gossypium herbaceum (Malvaceae),[20] Cyperus longus (Cyperaceae), Vitex pseudonegundo (Verbenaceae), Chenopodium ambrosioides (Chenopodiaceae),[21][22] Aristolochia indica (Aristolochiaceae),[23] Punica granatum (Punicaceae),[24] and Sarcostemma acidum (Asclepiadaceae).[25] However, the compound isolated from Gossypium, as well as other cotton seeds and okra (gossypol) has been abandoned for contraceptive use because it was found to cause permanent infertility in ten to twenty percent of users.[26] In Indian traditional medicine, uses of the neem tree were described in Ayurvedic ...
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Adjudin was derived from the anti-cancer drug lonidamine. Unlike other cancer drugs that attack proliferating cells generally, Adjudin narrowly targets a small number of cells, including those in the male testes. On the basis of this observation, the Population Council pioneered research into Adjudin as a male contraceptive.. Adjudin causes developing sperm cells to detach from the Sertoli cells that nurture them before they have finished maturing. The prematurely detached cells die, causing temporary infertility. One or two doses of Adjudin can prevent conception for a month or more, as it takes 64 days for a new cycle of sperm cells to develop.. Although Adjudin has not been shown to cause any loss of cells in skin or kidneys, the relatively large dose required to interrupt spermatogenesis is accompanied by some degree of toxicity. The margin between safety and efficacy is narrow. As a result, Council researchers are working to develop alternative formulations that are better absorbed, thus ...
Neem Leaf has been promoted as a natural male contraceptive. The debate over this has lead to research on the effectiveness of these herbs. What has been found is that Neem Leaf is not effective in natural male contraception. Only the oil of the Neem Seed
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Background: About 90% of the world�s contraceptive users are women. This gender-based usage has occurred due to the emphasis of family planning programs and contraception research. Condom, vasectomy and withdrawal are the only male contraception devices available with less assurance for men. For new male contraceptive to have an impact, ...
Groundbreaking new reproductive research from the University of Virginia School of Medicine has identified key molecular events that could be playing a critical role as sperm and egg fuse to create new life. The findings might one day lead to the creation of a male contraceptive.
The Male Contraceptive Shot (MCS) came under scrutiny when the study was shut down due to adverse effects, many complained that these effects were simply what women had to deal with on a day-to-day basis. [I must admit, I originally canned this post as mra-uk posted a far superior article but, following a chat with…
Medicinal chemists are tweaking a natural molecule that can be a deadly poison - a modified version might work as a nonhormonal male contraceptive.
Condoms or a vasectomy are basically the only contraceptive options currently available for men. But a new gene discovery by infertility researchers at the Centre for Reproductive Health at the University of Edinburgh suggests that the development of a male contraceptive pill could someday be pos...
RISUG is a clear gel thats injected into the penis to prevent sperm from reaching the finish line. Learn about the new male contraceptive RISUG.
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Makes more sense, but still, I disagree. But lets talk about birth control.. Modern birth control for women is possibly the most important invention of the last century, and Im very grateful for it. Its also brutal. The side effects for many women include migraines, mood swings, decreased libido, depression, severe cramps, heavy bleeding, aneurysm - and thats just a small fraction of them.. Discouragingly, a promising study on a new male contraceptive was canceled in large part due to… (wait for it)… side effects. To be clear, this list of side effects was about one-third as long as the known side effects for commonly used womens contraception. Theres a lot to unpack in that story alone. Ill simply point out that, as a society, we really dont mind if women suffer, physically or mentally, as long as it makes things easier for men.. But, men, Ive got good news. Even with the horrible side effects, women are (amazingly!) very willing to use birth control. Unfortunately, its harder to ...
Geneticists say that we should not yet add the male to the endangered species list, and for now all is not lost for the little modern Y. It was previously thought that the Y chromosome contained mostly junk DNA and that the production of the testes triggered by SRY was its only function. But it is now known that the genes remaining on the Y chromosome are particularly important for survival in males and for fertility. In about half of all couples affected by infertility the problem rests with the man. Disruption of the genes on Y can reduce sperm count causing infertility. Infertility research is now directing efforts towards understanding the strange Y and searching for a cure. On the flip side, the possibility of new male contraceptives that target the sperm producing regions of Y is being developed ...
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An experimental male contraceptive method involves heating the testicles so that they cannot produce sperm. Sperm are best produced at a temperature slightly below body temperature. The muscles around a males scrotum involuntarily tighten if the mans body temperature drops, and they loosen, allowing the testes to hang, if the body temperature rises. This is the bodys way of keeping the sperm at an ideal temperature.[citation needed] Although research has not addressed methods of applying heat, sperm production can be disrupted with increased temperature. Some suggest exposure to high temperatures (116 °F) can affect fertility for months. Methods used include hot water applied to the scrotum, heat generated by ultrasound, and artificial cryptorchidism (holding the testicles inside the abdomen) using specialized briefs. One of the initial experiments resulted in partial infertility lasting more than four years. Initial experiments suggest it is effective and safe, though there have not been ...
A means to block male fertility that doesnt involve potentially harmful hormone treatments has been unveiled by researchers in Australia and the UK.A male equivalent of the female oral contraceptive pill has long been sought-after by scientists. But, so far, every attempt has failed, owing mainly to the risk of significant side-effects or concerns over long-term impacts on fertility.
At the Population Councils Center for Biomedical Research, investigators pursue a greater understanding of the basic science of reproductive health. This allows us to understand the biological processes that affect fertility and reproduction and identify opportunities for future product development. Council research has advanced the fields understanding of selective hormone receptors with the goal of making contraceptive delivery systems safer and more effective. Our research on the biology and regulation of sperm cell activities may help inform contraceptive development for men and increase understanding of the underlying causes of male infertility.. Additional research focuses on identifying sperm function to promote the development of non-hormonal contraceptive methods and to understand the effects of the environment on reproductive health.. ...
Welcome to this weeks Research Roundup. These Friday posts aim to inform our readers about the many stories that relate to animal research each week. Do you have an animal research story we should include in next weeks Research Roundup? You can send it to us via our Facebook page or through the contact form…
Important information about COVID-19 (coronavirus). We are committed to helping our members get access to the care they need.. ...
The 24-day oral contraceptive regimens containing a progestogen with a long half-life are generally more effective than conventional 21-day regimens.
Women of child-bearing potential must have a negative serum pregnancy test within 14 days prior to the first day of study treatment. Women who are postmenopausal for at least 1 year (defined as , 12 months since last menses) or are surgically sterilized do not require this test. Women of child-bearing potential and their male partners must agree to practice a medically acceptable contraceptive regimen from study treatment initiation until at least 30 days after the last administration of RH-1. Adequate methods of contraception are double barrier methods (condoms with spermicidal jelly or foam, and diaphragm with spermicidal jelly or foam), oral, depot and injectable contraceptives, and intrauterine device (IUD). RH-1 should not be administered to women who are breast feeding ...
While many birth control methods contain hormones, there are others that do not. Here are eight non-hormonal birth control options worth looking into.
Pregnancy or active breast-feeding. Female patients of childbearing potential (not postmenopausal for at least 5 years or surgically sterilized) must agree not to become pregnant during the duration of the study. Specifically, they must agree to use an appropriate contraceptive regimen. Acceptable regimens include abstinence, systemic hormones, intrauterine devices and barrier methods, such as cervical caps, male or female condoms, or diaphragms with concomitant intravaginal spermicide. A barrier method must have been used without failure for at least 1 year immediately preceding entry into the study ...
Best Poster Award for the poster entitled Structural importance of PSP94 relevant for its function at the International Congress on Gamete Biology: Emerging Frontiers in Fertility and Contraceptive Development jointly organized by National Institute of Immunology, India and Hyogo College of Medicine, Japan held at the National Institute of Immunology (NII), New Delhi from 22-25 February, 2006 ...
A new birth control pill for men appears to be safe when used daily, a new study finds. But dont expect a pill for sale for at least 5 years or more.
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2016 · Classification of Progestins: Combination birth control pills include an estrogen and one progestin. 17. Elmer stringless cod, its sinuously reorganization. 08. But the pill can have other benefits, testosterone and progestin male hormonal contraception too. 2013 · My Boyfriend Boils His Balls for Me After birth control did scary things to my body, my boyfriend and I got desperate. Toileting and nodular thin Northrop caribous its undervalued or relegated lissomly. 01. Deutsch, MD, MPH. 2016 · The practice of contraception is as old as human existence. 29. Androgen disorders cannot be cured but they can be treated, usually with medication. Cyclofem® and Mesigyna® injections contain synthetic (man-made) forms of the hormones estrogen and progestin (which. 07. There are eight types of progestins. Definition Contraception (birth control) prevents pregnancy by interfering with the normal process of ovulation, fertilization, and implantation All products and services featured are selected ...
The poison historically used on the tips of arrows in eastern Africa is the basis for a new male contraceptive candidate, according to a new study.. The chemical ouabain, which is found in the African plants Acokanthera schimperia and Strophanthus gratus, was used by hunters and warriors to stop the hearts of their targets.. An analogue of the chemical is found to essentially bypass the heart effects, and instead cripples the motility of sperm cells, researchers report in the Journal of Medicinal Chemistry, published by the American Chemical Society.. The team found its target in the α4 protein, a molecule unique to sperm cells, which is crucial to sperm cells moving naturally, and thus fertilizing egg cells.. The scientists from the University of Minnesota and the University of Kansas tested different derivative compounds they created in attempting to alter the natural ouabain enough to bypass crucial damage on target systems, like the cardiovascular system.. Through chemistry, they removed ...
Testosterone Undecanoate that also might be known as Andriol or Jatenzo (trade names of this form of testosterone, but it is coming in form of oral tablets) and also as Aveed or Nebido (in form of injection) is a synthetic anabolic androgenic steroids (AAS) having the attached undecanoate ester of testosterone. This steroid is basically offering the exact same hormone - testosterone, as any other testosterone form such as testosterone enanthate, cypionate or propionate. These are better known and more used testosterones. Testosterone undecanoate instead, is a the longest acting testosterone requiring least injections ...
Testosterone is considered as the base steroid for most of all cycles. Additionally Testosterone Enanthate has ability to reduce the activity of catabolic hormones and promotes gain in the muscle mass more effectively. It can be said that the only difference between Cypionate and Enanthate is that Enanthate is more long acting than Testosterone Cypionate. Testosterone Enanthate takes effect on testosterone level for two or three week depends on the condition of your body. On the other hand Testosterone Enanthate has potential adverse effects on the body as other Testosterones Cypionate has.. These are in many ways easy to control. It can be said that, the most common side effects are based on increase of estrogen level. In order to minimize the estrogen based side effects it is recommended to use an anti-estrogen additionally (such as Tamoxifen, Proviron, Anastrozol).. In addition to estrogen based effects, Testosterone Enanthate has DHT (dihydrotestosterone) related effects such as hair loss, ...
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Results: The results shows that the higher the solvent polarity, the better the yield of extract thus the extract yield was higher in aqueous followed by methanol, ethyl acetate, chloroform and n-hexane in that order. Furthermore, the phytochemical analyses of all the five extracts of Carica papaya seed showed the presence of various compounds. The phytochemicals include flavonoids, alkaloids, tannins, saponins and cardiac glycoside in varying amounts. Anthraquinones was not detected in all the five extracts. The LD50 of the aqueous, methanol, ethyl acetate, chloroform and n- hexane extracts of Carica papaya seed in rat was greater than 5000 mg /kg body weight while the results of the weight changes shows that there is no statistically significant (p,0.05) difference in weight gain or weight loss in rats in most of the experimental groups administered with either of the five extracts of Carica papaya seed as compared with the control rats. ...
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CHAPEL HILL, N.C. - The ideal male contraceptive would be inexpensive, reliable and reversible. It would need to be long acting but have few side effects. New research from the University of North Carolina at Chapel Hill School of Medicine, published in BioMed Centrals open-access journal Reproductive Biology and Endocrinology, used commercially available therapeutic ultrasound equipment to reduce sperm counts of male rats to levels which would result in infertility in humans. Ultrasounds potential as a male contraceptive was first reported nearly 40 years ago. However, the equipment used at that time is now outdated and no longer available. UNC researchers used these experiments as a starting point to see if modern ultrasound equipment usually used for physical therapy could be used as a male contraceptive. The team, led by James Tsuruta, PhD, found that by rotating high frequency (3MHz) ultrasound around the testes they were able to cause uniform depletion of germ cells through the testes. ...
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1. The Mircette™ Study Group. An open-label, multicenter, noncomparative safety and efficacy study of Mircette™, a low-dose estrogen-progestin oral contraceptive. Am J Obstet Gynecol. 1998;179:S2-S8.. 2. Anderson FD, Hait H. A multicenter, randomized study of an extended cycle oral contraceptive. Contraception. 2003;68:89-96.. 3. Bachmann G, Sulak PJ, Sampson-Landers C, Benda N, Marr J. Efficacy and safety of a low-dose 24-day combined oral contraceptive containing 20 micrograms ethinylestradiol and 3 mg drospirenone. Contraception. 2004;70:191-198.. 4. Archer DF, Ellman H, for the Loestrin-24 Study Group. Bleeding profile of a new 24-day oral contraceptive regimen of norethindrone acetate 1 mg/ethinyl estradiol 20 mcg compared with a 21-day regimen. Paper presented at: Annual Meeting of the American Society for Reproductive Medicine; October 15-19, 2005; Montreal, Canada.. 5. Archer DF, Ellman H, for the Loestrin-24 Study Group. Efficacy and safety of a 24-day oral contraceptive regimen of ...
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... is under investigation as a potential male contraceptive and as the first male birth control pill. Antiandrogens such as ... Srivastava RP, Bhaduri AP (1989). "Emerging concepts towards the development of contraceptive agents". Prog Drug Res. 33: 267- ... have been studied for potential use as male hormonal contraceptives. While effective in suppressing male fertility, their use ... Gombe S (April 1983). "A review of the current status in male contraceptive studies". East Afr Med J. 60 (4): 203-11. PMID ...
"Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates". Nature Communications. 12 (1 ... Male contraceptives, also known as male birth control, are methods of preventing pregnancy that solely involve the male ... Wikimedia Commons has media related to Contraception for males. Male Contraceptive Initiative Male Contraception Information ... This experimental male oral contraceptive is a male hormone like testosterone, and a progestin. Currently conducting research ...
Kjaergaard N, Kjaergaard B, Lauritsen JG (June 1988). "Prazosin, an adrenergic blocking agent inadequate as male contraceptive ... Homonnai ZT, Shilon M, Paz GF (May 1984). "Phenoxybenzamine-an effective male contraceptive pill". Contraception. 29 (5): 479- ... which could make it an effective male contraceptive. This effect is completely reversible, and is believed to be the result of ... Due to these actions, phenoxybenzamine is also useful for the treatment of premature ejaculation in men. Phenoxybenzamine is ...
"Administration of norethandrolone and testosterone as a contraceptive agent for men". Contraception. 11 (2): 193-207. doi: ... It can also cause estrogenic effects like fluid retention, breast tenderness, and breast enlargement in men and liver damage. ... Neumann F, Diallo FA, Hasan SH, Schenck B, Traore I (1976). "The influence of pharmaceutical compounds on male fertility". ... Norethandrolone has been studied for use in male hormonal contraception. J. Elks (14 November 2014). The Dictionary of Drugs: ...
"Triptolide is a reversible non-hormonal male contraceptive agent in mice and non-human primates". Nature Communications. 12 (1 ... was an effective birth control for male mice and male cynomolgus monkeys, but noted that other chemicals present in the plant ... Evidence is lacking that Tripterygium is either safe or effective as a method of birth control in men. Two trials found less ... Lopez, LM; Grimes, DA; Schulz, KF (November 2005). "Nonhormonal drugs for contraception in men: a systematic review". ...
"Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates". Nature Communications. 12 (1 ... A 2021 trial in mice and monkeys suggested that triptonide may offer a reversible male contraceptive. "Triptonide". pubchem. ... Institute, The Lundquist (April 1, 2022). "Male Birth Control Pill: Natural Compound Discovered With "Ideal" Contraceptive ...
There have been experiments using a SARMs C-6 and S-23 on male mice as a contraceptive agent. Treatment of osteoporosis has ... S-23 - Under development as a male hormonal contraceptive RAD140 (Testolone) Acetothiolutamide - High-affinity AR full agonist ... The British men's 4x100 relay team was stripped of their 2021 Tokyo Olympic silver medal after CJ Ujah tested positive for two ... PF-06260414 was found to be well tolerated among the male population clinically tested. As expected with SARMs there was a ...
In men, they are being investigated in the treatment of benign prostatic hyperplasia and also as potential contraceptive agents ... Amory JK (March 2007). Contraceptive developments for men. Drugs Today (Barc.) 43: 179-192. Hembree WC, Cohen-Kettenis PT, ... In men, the reduction in LH subsequently leads to rapid suppression of testosterone production in the testes; in women it leads ... Subcutaneously administered agents are also associated with injection-site reactions and abarelix (neither of these being GnRH ...
... reversible male contraceptives, or female contraceptives through the use of intravaginal contraceptive devices. Moreover, as ... acrosin could thus serve as a novel target for contraceptive agents. Acrosin may represent as a uniquely druggable target due ... Acrosin regulation has been found to occur through protein C inhibitor (PCI). PCI is present in the male reproductive tract at ... This suggests the further role of acrosin inhibitors as potentially viable agents in the prevention of HIV transmission. Adham ...
... which in turn may improve its effectiveness as an antispermatogenic agent and male contraceptive. This is salient and ... as an oral male hormonal contraceptive: induction of infertility and recovery of fertility in adult male rabbits". Journal of ... as male contraceptives based on androgens alone have failed to produce satisfactory azoospermia in around one-third of men. ... is under development for potential use as a birth control pill for men and in androgen replacement therapy for men. ...
... are working on the discovery and development of non-hormonal male contraceptive agents and the investigation of contraceptive ... Miao, Z.; Guan, X.; Jiang, J.; Georg, G. I. BRDT Inhibitors for Male Contraceptive Drug Discovery: Current Status. In Targeting ... Her research interests are total synthesis and semisynthesis as well as evaluating biologically active agents. A cited expert ... Georg is the Principal Investigator for a National Institutes of Health Center grant for the Contraceptive Discovery, ...
Oral Contraceptives, and Ovulatory Agents". AMA drug evaluations. Publishing Sciences Group. p. 540-572. ISBN 978-0-88416-175-2 ... In addition, it is used as a form of high-dose estrogen therapy in the palliative treatment of prostate cancer in men. ... It has also been used in feminizing hormone therapy for transgender women and in the treatment of prostate cancer in men. ... 406-. ISBN 978-3-88763-075-1. I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: ...
Yan has also been innovative in the contraceptives field with the novel idea of developing non-hormonal male contraceptives ... Triptonide acts as a reversible non-hormonal contraceptive agent and is the first compound in over 50 years to be tested in ... This discovery established Triptonide as a drug candidate for "The Pill" for men. As a young scientist, Dr. Yan was the first ... He is Director of National Center for Male Reproductive Epigenomics and served as the editor-in-chief of the journal Biology of ...
... mass sterilizing agents, and prenatal sex discernment (because families often continue to have children until a male is born. ... such as better contraceptives, ... The Ehrlichs suggested that if they could choose a male child ... They suggest incentives for men who agree to permanent sterilization before they have two children, as well as a variety of ... He mentions his support for government mandated sterilization of Indian males with three or more children. In the rest of the ...
Aitken started to focus his future study on clinical research into male contraceptives, androgen physiology, and male ... developing the potential contraceptive potential of ZP3 peptides and other chemical compositions of these contraceptive agents ... Besides discovering oxidative stress, Aitken also improved the male contraceptive vaccine in later years. His paper in the ... In more recent years, Aitken has been focusing on translational research in male contraception and male infertility. Since 2016 ...
"Long-acting contraceptive agents: design of the WHO Chemical Synthesis Programme". Steroids. 41 (3): 243-53. doi:10.1016/0039- ... has been tested successfully in combination with testosterone buciclate as a long-lasting injectable contraceptive for men as ... Goebelsmann U (1986). "Pharmacokinetics of Contraceptive Steroids in Humans". In Gregoire AT, Blye RP (eds.). Contraceptive ... The drug has a well-established safety record owing to the use of levonorgestrel as an oral contraceptive since the 1960s. List ...
64, 66 Frankl VE (2000). Man's search for ultimate meaning. New York, NY, USA: Basic Books. pp. 139-40. ISBN 0-7382-0354-8. ... Therapies associated with depression include interferon therapy, beta-blockers, isotretinoin, contraceptives, anticonvulsants, ... antimigraine drugs, antipsychotics, hormonal agents such as gonadotropin-releasing hormone agonist, magnetic stimulation to ... in men), addison's disease, cushing's syndrome, pernicious anemia, hypothyroidism, hyperparathyroidism, Lyme disease, multiple ...
... with thalidomide seems to be increased when patients are treated with oral contraceptives or other cytotoxic agents (including ... Thalidomide should not be used by men or women who are trying to father or conceive a child, or who cannot or will not follow ... In males who are taking the medication, contraception is essential if a partner could become pregnant. It is an ... Around that time, the wife of a man who was dying of multiple myeloma and whom standard treatments had failed, called Folkman ...
... has been studied for use as a potential male hormonal contraceptive in combination with testosterone in men. Long-acting ... van Vloten WA, Sigurdsson V (2004). "Selecting an oral contraceptive agent for the treatment of acne in women". American ... Moudgal NR, Suresh R (1995). "Some thoughts on development of chemically based male contraceptives" (PDF). Current Science ( ... Cornia, Paul B; Anawalt, Bradley D (2005). "Male hormonal contraceptives: a potentially patentable and profitable product". ...
... he remains one of the United States Air Force most decorated Enlisted men and was the only man in the Eighth Air Force to fly ... Born: Martin Knowlton, American travel agent and hostel administrator, who established Elderhostel; in Dallas (d. 2009) France ... prohibited the sale or prescription of contraceptives, as well as forbidding the distribution of "antinatalist propaganda", as ... The group then took the Arthur brothers to the county fairgrounds and burned the men at the stake. With the help of an army of ...
An astute, practical man who uses a clue found at the scene of the crime to trace events back to Verloc's home. Although he ... Verloc is also a businessman who owns a shop which sells pornographic material, contraceptives and bric-a-brac. He lives with ... IMDb: The Secret Agent (1957, Canada) IMDb: The Secret Agent (1957, UK) IMDb: The Secret Agent (1959) IMDb: The Secret Agent ( ... The Secret Agent (1992) BBC Genome: The Secret Agent (2001) BBC Genome: The Secret Agent (1951) BBC Genome: The Secret Agent ( ...
If numerous males are in a particular area, then they compete more with the females. If fewer males or more females are present ... Opponents of contraceptive methods point out that fertility control cannot provide meat and proves ineffective over time as ... and then administering a chemical euthanizing agent or extermination by firearm. A main issue in questioning the humaneness of ... Males compete for the opportunity of breeding females. Sparring among males determines a dominance hierarchy. Bucks attempt to ...
Male-to-Female Transsexuals: Hormonal therapy is prescribed for male-to-female transsexuals to induce breast formation and a ... Hassoun LA, Chahal DS, Sivamani RK, Larsen LN (June 2016). "The use of hormonal agents in the treatment of acne". Seminars in ... oral contraceptive], at a dose of 500mg/d, flutamide caused a dramatic decrease (80%) in total acne, seborrhea and hair loss ... The combination has specifically been used to treat male peripheral precocious puberty due to familial male-limited precocious ...
It is more common in men than women. Often chronic pancreatitis starts between the ages of 30 and 40 while it is rare in ... There are various oral hypoglycemic agents that contributes to pancreatitis including metformin. But, glucagon-like peptide-1 ( ... There are seven classes of medications associated with acute pancreatitis: statins, ACE inhibitors, oral contraceptives/hormone ... A number of infectious agents have been recognized as causes of pancreatitis including: Viruses Coxsackie virus Cytomegalovirus ...
... and the androgen testosterone is under development as a transdermal gel formulation for use as a hormonal contraceptive in men ... G.W.A Milne (1 November 2017). Ashgate Handbook of Endocrine Agents and Steroids. Taylor & Francis. pp. 158-. ISBN 978-1-351- ... Oral Contraceptive Pills: Combinations, Dosages and the Rationale behind 50 Years or Oral Hormonal Contraceptive Development. ... In healthy young men, SGA alone at a dose of 2 to 3 mg/day as a transdermal gel (delivering 200-300 μg/day SGA) for 2 weeks ...
Chase was released on a fifteen hundred dollar bail and when finally brought to trial a jury that consisted of solely men ... In May 1878, Chase was arrested by Anthony Comstock, chief agent in the New York Society for the Suppression of Vice, for ... New York Times (8157-1922) [New York, N.Y] 05 Dec 1888:8. Black Market Birth Control: Contraceptive Entrepreneurship and ... Women who wanted to seek employment often struggled due to men being prejudiced which decreased their chances. Luckily for ...
Multicenter Clinical Investigation Employing ethinyl estradiol combined with dl-norgestrel as a Postcoital Contraceptive agent ... The male victims of rape felt powerless because they believed they lost their male pride and dignity. Many men reported ... heterosexual men are the most likely to participate in victim-blaming. Men tend to blame other men for their own sexual ... Male rape victims may be hesitant to report rapes due to the stigma surrounding male rape, which can cause humiliation or fear ...
... has been studied as a male contraceptive and was found to be highly effective. At a dosage of 0.45 mg/day, it ... I.K. Morton; Judith M. Hall (6 December 2012). Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Springer ... These findings contributed to the conclusion that estrogens would be unacceptable as contraceptives for men. In 2021, mestranol ... Jackson H (November 1975). "Progress towards a male oral contraceptive". Clin Endocrinol Metab. 4 (3): 643-63. doi:10.1016/ ...
Goebelsmann U (1986). "Pharmacokinetics of Contraceptive Steroids in Humans". In Gregoire AT, Blye RP (eds.). Contraceptive ... Geller J, Volk H, Lewin M (October 1961). "Objective remission of metastatic breast carcinoma in a male who received 17-alpha ... Geller J, Fruchtman B, Newman H, Roberts T, Silva R (February 1967). "Effect of progestational agents on carcinoma of the ... OHPC was studied by Schering for use as a progestogen-only injectable contraceptive at a dose of 250 to 500 mg once a month by ...
Oral contraceptive use is also associated with increased risk of vaginal thrush. In pregnancy, higher levels of estrogen make a ... "Thrush in men and women". nhs.uk. 2018-01-09. Retrieved 2021-01-16. Skoczylas, MM; Walat, A; Kordek, A; Loniewska, B; Rudnicki ... Example products are herbal preparations, probiotics and vaginal acidifying agents. Other alternative treatment approaches ... include switching contraceptive, treatment of the sexual partner and gentian violet. However, the effectiveness of such ...
"The Missionary as Change Agent," Presbyterian Historical Society, The National Archives of the PC(USA), February 9, 2018. ... Poethig often personally took public, socially progressive positions on abortion and contraceptive rights, LGBTQ inclusion and ... which explored feminine and feminist theologies and promoted equal partnership with men at all levels of religious life. It ...
Long-term use of oral contraceptives is associated with increased risk of cervical cancer in women who have had HPV. Women who ... When cisplatin is present, it is thought to be the most active single agent in periodic diseases. Such addition of platinum- ... It was more common in the second wives of men whose first wives had died from cervical cancer. It was rare in Jewish women. In ... Women who have sex with men who have many other sexual partners or women who have many sexual partners have a greater risk. Of ...
From 1965 to 1970, black militant males, especially younger men from poverty-stricken areas, spoke out against birth control by ... The combined oral contraceptive pill, popularly known as "the Pill", was approved for sale as a medicine in US markets in 1957 ... If an institution is deliberately maintained and expanded by discernible agents, though all are aware of the hecatombs of ... Congresswoman Shirley Chisholm wrote in 1970 that the linking of abortion and genocide "is male rhetoric, for male ears." ...
Male physicians began to replace female midwives in Europe and the United States in the 1700s. The rise in status and ... The WHO does not recommend the use of antispasmodic agents for prevention of delay in labour. For years an episiotomy was ... This is also an optimal time for uptake of long-acting reversible contraception (LARC), such as the contraceptive implant or ... The conservatives argued that it was immoral for a woman to be exposed in such a way in front of a man. For that reason, many ...
A series revealing the political game behind a secret deportation of two Egyptian men suspected of terrorism, conducted by ... A series revealing the side-effects of third-generation contraceptive pills, and that the international medical companies have ... were taken from Bromma airport in Sweden in December 2001 to Egypt in a covert operation by US agents and handed over to ... 2001: "The hidden price of contraceptive pills". Investigative program. ...
It is also used in Japan to treat benign prostatic hyperplasia (BPH) in men. The medication is used alone and is not formulated ... The effective ovulation-inhibiting or contraceptive dosage of allylestrenol in women has been studied, albeit limitedly. At 20 ... Kanimoto Y, Okada K (November 1991). "[Antiandrogen therapy of benign prostatic hyperplasia--review of the agents evaluation of ... At a dosage of 50 mg/day, allylestrenol has been found to suppress circulating testosterone levels by 78% in men with BPH. This ...
Exogenous androgen supplements can be used as a male contraceptive. Elevated androgen levels caused by use of androgen ... ISBN 978-0-80-365868-4. Generic term for an agent (usually a hormone, such as testosterone or androsterone) that stimulates ... In males, certain Y chromosome genes, particularly SRY, control development of the male phenotype, including conversion of the ... To examine neurogenesis, wild-type male rats were compared with male rats that had testicular feminization mutation (TMF), a ...
v. Day, 370 U.S. 348 (1962) Images of naked men are not, per se, obscene, extending Olesen in a way that spurred an increase in ... Bivens v. Six Unknown Named Agents, 403 U.S. 388 (1971) Individuals may sue federal government officials who have violated ... and advertisement of contraceptives to both adults and minors are unconstitutional. Planned Parenthood v. Casey, 505 U.S. 833 ( ... A statute that gives benefits to the spouses of male members of the uniformed services, but not to the spouses of female ...
Estrogen-containing oral contraceptives Men with recent heart surgery, malnutrition, magnesium deficiency, or severe anemia ... 1999). Dictionary of pharmacological agents (1st ed.). London: Chapman & Hall. ISBN 978-0-412-46630-4. Tan X, Machmuller MB, ... I. The influence of estradiol and estriol on hepatic disposal of sulfobromophthalein (BSP) in man". J Clin Invest. 43 (10): ... "Association between serum alkaline phosphatase and primary resistance to erythropoiesis stimulating agents in chronic kidney ...
In the Latin Church, Catholic men may serve as deacons or priests by receiving sacramental ordination. Men and women may serve ... Catholic women had used contraceptives at some point in their lives and that 72% of Catholics believed that one could be a good ... becoming vehicles for the transmission of the infectious agent. In particular, they must avoid any risk to the health of those ... and the episcopate is always restricted to celibate men. Men who are already married may be ordained in certain Eastern ...
The preferred puberty-suppressing agent for both individuals assigned male at birth and individuals assigned female at birth is ... Task Force on Oral Contraceptives; Koetsawang, Suporn; Mandlekar, A.V.; Krishna, Usha R.; Purandare, V.N.; Deshpande, C.K.; ... Bornstein, Kate (2013). My Gender Workbook, Updated : How to Become a Real Man, a Real Woman, the Real You, or Something Else ... "Ovary function is preserved in transgender men at one year of testosterone therapy , Endocrine Society". www.endocrine.org. ...
There is no specific treatment, although most patients are either given an anti-platelet or anti-coagulation agent to prevent ... migraines and contraceptive use. Hereditary connective tissue diseases include autosomal polycystic kidney disease, Ehlers- ... the peak age of presentation is approximately 45 years with a slight gender predisposition towards males (53-57%). Cervical ... Management is often using either antiplatelet agents (i.e. aspirin) or anti-coagulation to prevent development of thrombus. ...
... reducing the reliance of women on men for contraceptive practice, encouraging the delay of marriage, and increasing pre-marital ... Agents. 31 (3): 189-92. doi:10.1016/j.ijantimicag.2007.11.010. PMID 18248798. Abraham EP (1987). "Cephalosporins 1945-1986". ... "Why the Oral Contraceptive Is Just Known as "The Pill"". Smithsonian Magazine. smithsonianmag.com. Archived from the original ... The history of the development of oral contraceptives is thus closely tied to the birth control movement and the efforts of ...
... a chemical agent for killing scabies. Spermicide - a contraceptive agent to render sperm inert and prevent fertilization. ... Homicide - the act of killing of a person (Latin: homo "man"). Justifiable homicide - a defense to culpable homicide (criminal ... Algaecide - a chemical agent that kills algae Acaricide - a chemical agent that kills mites Avicide - a chemical agent that ... Pediculicide - an agent that kills head lice. Pesticide - a general term to describe an agent used to destroy or repel a pest. ...
The concentration of thiomersal used in vaccines as an antimicrobial agent ranges from 0.001% (1 part in 100,000) to 0.01% (1 ... Military personnel used Rudyard's Kipling's poem "The White Man's Burden" to explain their imperialistic actions in Cuba, the ... or contraceptive counseling regardless of whether they received the HPV vaccine. Thousands of Americans die each year from ... Unknowingly, American soldiers acted as agents of disease transmission, fostering bacteria in their haphazardly made camps. ...
One type of contraceptive includes barrier methods. One barrier method includes condoms for males and females. Both types stop ... Other hazardous agents can affect the overall health of the woman and reduce the delivery of nutrients to the fetus. Radiation ... Types of Contraceptives The copper IUD has been provided less frequently than other contraceptive methods but there have been ... Contraceptive Accessibility The updated contraceptive guidelines in South Africa attempt to improve accessibility by providing ...
Foran, Clare (August 3, 2016). "A Step Toward Equal Pay for Men and Women". The Atlantic. Atlantic Media. Retrieved September ... when the Trump administration issued new regulations allowing insurers and employers to opt out of contraceptive mandates, ... the suspension of a state district court judge who allegedly assisted an illegal immigrant from being detained by an ICE agent ...
Shafik, Ahmed (May 1992). "Contraceptive efficacy of polyester-induced azoospermia in normal men". Contraception. 45 (5): 439- ... for measuring the degree to which human saliva is a good cleaning agent for dirty surfaces. Medical Education: Akira Horiuchi, ... doi:10.1111/j.1465-5922.1996.00165.x. Mills, C.; Llewelyn, M.; Kelly, D.; Holt, P. (1996). "A man who pricked his finger and ... Medicine - Presented to James F. Nolan, Thomas J. Stillwell, and John P. Sands, Jr., medical men of mercy, for their ...
The Ruler of the Universe is a man living in a small shack on a world that can only be reached with a key to an improbability ... As a final note, Zaphod explains that his great-grandfather is "the Fourth" due to an accident with a contraceptive and a time ... In the Illustrated Guide to the Galaxy, the pair are played by Douglas Adams and Ed Victor (his literary agent). The characters ... Zaphod describes being bored by a man in a shack and his cat for over a year. Appears in: Fit the Twelfth of the radio series ...
Substantial numbers of men who have sex with men in developed countries use lubricants containing nonoxynol-9.[citation needed ... they are less desirable than other agents. Additionally, clinical trials have not demonstrated these agents to be effective at ... it remains a contraceptive option for women at low risk. Efforts are underway to develop safe and effective topical ... One such agent is BufferGel, a spermicidal and microbicidal gel formulated to maintain the natural protective acidity of the ...
Brown has said he personally believes marriage is between a man and a woman, but would still oppose a constitutional amendment ... This amendment would have allowed individual healthcare workers and hospitals to refuse to provide emergency contraceptive care ... to continue his studies at Boston College and continued to work as a model represented by Boston agent, Maggie Trichon of ... Brown voted for a 2004 state constitutional amendment to define marriage as between "one man and one woman" and which would ...
PSC predominantly affects males (60-70%) of 30-40 years of age. The disease has an incidence is 0.4-2.0 cases/100,000 and a ... Lastly, some agents (rimpaficin and 17β-estradiol) were shown to hinder proper localization of hepatocyte transporters by ... 17 Bland cholestasis is almost always caused by anabolic steroids or estrogen contraceptive use, while many drugs may cause ... The novel agent norUDCA (24-norursodeoxycholic acid) can be passively absorbed by cholangiocytes. This leads to bicarbonate ...
A New Hypoglycemic Agent". J Am Chem Soc. 81 (9): 2220-25. doi:10.1021/ja01518a052. "Procédé de préparation de chlorhydrate de ... R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. ... Luque-Ramírez M, Nattero-Chávez L, Ortiz Flores AE, Escobar-Morreale HF (March 2018). "Combined oral contraceptives and/or ... Nicholson W, Bolen S, Witkop CT, Neale D, Wilson L, Bass E (January 2009). "Benefits and risks of oral diabetes agents compared ...
In trans men who take testosterone and have not had a hysterectomy, the conversion of testosterone into estrogen via ... This risk reduction continues for at least fifteen years after contraceptive use has been stopped. Obese women may need higher ... Also, endometrial stromal sarcomas can be treated with hormonal agents, including tamoxifen, hydroxyprogesterone caproate, ... Progestin is present in the combined oral contraceptive pill and the hormonal intrauterine device (IUD). Combined oral ...
These agents work to lower LDL-C levels and are also associated with a decrease in CVD mortality, CVD morbidity, and total ... UpToDate suggests screening males at age 35 and females at age 45 in those without any risk of cardiovascular disease. All ... Some medications that may contribute to dyslipidemia are thiazide diuretics, beta blockers, oral contraceptives, atypical ... This agent consists of eicosapentaenoic acid (EPA), an omega-3 fatty acid from fish oil and works to lower the hepatic ...
Oral contraceptives: may reduce plasma concentrations of valproate. Primidone: may accelerate metabolism of valproate, leading ... R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. ... February 1983). "[Anti-epileptic agents during pregnancy. A prospective study on the course of pregnancy, malformations and ... Herzog AG, Farina EL, Blum AS (June 2005). "Serum valproate levels with oral contraceptive use". Epilepsia. 46 (6): 970-971. ...
A BBC News crew filming the BBS rally at Maharagama on 17 February 2013 were surrounded by a mob of twenty young men who ... For example, Wimal Weerawansa, a Sri Lankan government minister, has asked that BBS challenge "the Norway agent in its ... and ban some contraceptives. In February 2013 former BBS leader Kirama Wimalajothi called for a ban on burqas in the country. ...
Georgia arrives back to find that Kyle has been visited by Greg Keys, a man she met in Germany. She admits that they had a ... Kyle asks Georgia to try for another baby and she agrees to throw away her contraceptive pills, but changes her mind as she ... The actress was travelling through Kakadu with her boyfriend when she received a call from her agent about a regular role on ... She later returned home, shortly after a man called Greg Keys (Ryan Faucett) revealed to Kyle that he was in love with her. A ...
They showed that silicone breast implants did not cause connective tissue diseases or gammopathies; that oral contraceptives ... 6,576,256, Treatment of patients at Elevated Cardiovascular Risk with a Combination of a Cholesterol Lowering Agent, an ... the first convincing evidence that the anti-phospholipid antibody was a risk factor for thromboembolic disease in healthy men. ... did not prevent rheumatoid arthritis; and that women risked developing lupus from oral contraceptives and post-menopausal ...
Antiandrogen agents block androgen receptors, thereby inhibiting the effects of male sex hormones. These agents may be used to ... Oral Contraceptives. Class Summary. Oral contraceptive agents reduce the secretion of luteinizing hormone (LH) and follicle- ... oral contraceptives). This agent is more effective when used in combination with oral contraceptive pills. Due to the potential ... Acne Agents, Topical. Class Summary. Various topical over-the-counter (OTC) and prescription agents are available to treat acne ...
Results of search for su:{Contraceptive agents, Male.} Refine your search. *. Availability. * Limit to currently available ... Guidelines for the use of androgens in men. by WHO Special Programme of Research, Development and Research Training in Human ...
... but their adverse effects on male reproductive function remain unclear. The testis expresses somatic calcineurin and a sperm- ... Contraceptive Agents, Male / pharmacology* * Cyclosporine / pharmacology* * Epididymis / cytology * Epididymis / drug effects * ... Sperm calcineurin inhibition prevents mouse fertility with implications for male contraceptive Science. 2015 Oct 23;350(6259): ... inhibition of this sperm-specific calcineurin may lead to the development of a reversible male contraceptive that would target ...
Contraceptive Agents [‎38]‎. Contraceptive Agents, Female [‎31]‎. Contraceptive Agents, Male [‎3]‎. Contraceptive Devices [‎22 ...
Contraceptive Agents [‎38]‎. Contraceptive Agents, Female [‎31]‎. Contraceptive Agents, Male [‎3]‎. Contraceptive Devices [‎22 ...
This medicine is not a contraceptive, so always use precautionary agents. If you want to get more detail about ED and men ... This medication helps men to experience better erections that last for a longer time. Sildenafil Citrate 100mg drug helps men ... For what age is Fildena recommended in men?. Men generally use Fildena Sildenafil 100mg within 18 to 45 years of age. Consult ... If you want to get more detail about ED and men impotence then have a peek here: EDBalance.. Erectile dysfunction is a general ...
Youre wanting a contraceptive that works on men and women? One with no side-effects? And a counter-agent for contraceptives - ... So: a contraceptive that works on male and female humans, but not on other species, with no side effects? Plus, it should be ... Develope a chemical contraceptive that can be added to municiple water supplies and will equally affect male and females of the ... Develope a chemical contraceptive that can be added to municiple water supplies and will equally affect male and females of the ...
... will reversibly block reproduction and therefore constitute ideal candidates for a non-hormonal male contraceptive agent. ... 2020). Testis-specific serine kinase protein family in male fertility and as targets for non-hormonal male contraception†. ... As part of this task, we are interested in identifying the molecule(s) involved in these events in male germ cells, among which ... Role of testis-specific kinases in male fertility and as targets for contraception. Our research is focused on understanding ...
Contraceptive Agents Medicine & Life Sciences 17% * Organized Financing Medicine & Life Sciences 13% ... The majority of unintended pregnancies occurred when men or their partners were using contraceptives; 58% of contraceptive ... The majority of unintended pregnancies occurred when men or their partners were using contraceptives; 58% of contraceptive ... The majority of unintended pregnancies occurred when men or their partners were using contraceptives; 58% of contraceptive ...
Antiandrogen agents block androgen receptors, thereby inhibiting the effects of male sex hormones. These agents may be used to ... Oral Contraceptives. Class Summary. Oral contraceptive agents reduce the secretion of luteinizing hormone (LH) and follicle- ... oral contraceptives). This agent is more effective when used in combination with oral contraceptive pills. Due to the potential ... Acne Agents, Topical. Class Summary. Various topical over-the-counter (OTC) and prescription agents are available to treat acne ...
... contraceptive agents or postmenopausal hormone replacement therapy). Hepatitis C was present in 57,1% of the patients (71,4% of ... Seven patients were females (25%) and 21 were males (75%). Alcohol intake was the predominant etiological factor in male ... the males and 14,3% of the females). In light microscopy of 23 patients, 86,9% had subepidermal bullae and 95,6% had deposits ...
All of their data suggest that triptonide is a highly promising non-hormonal male contraceptive agent for men because it ... Reference: "Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates" by Zongliang Chang ... and reversible male contraceptive agent in pre-clinical animal models. Despite tremendous efforts over the past decades, the ... 2 Comments on Male Birth Control Pill: Natural Compound Discovered With "Ideal" Contraceptive Effects * Lee Findley , April 4 ...
The world is ready for a male contraceptive agent, and we are happy to help make this a reality by working with NICHD, said Dr ... In a 2019 survey from the Male Contraceptive Initiative, 70% of men aged 18 to 44 said, they are very or somewhat interested ... which conducts research in the synthesis and testing of both male and female contraceptive agents. ... U of M male contraceptive grant focuses on access, affordability. By Nick Longworth. ...
... the causative agent of tuberculosis, explains a study published November 14 in the open-access journal PLoS Pathogens. ... New male contraceptive does not involve hormones. Nov 24, 2022. 0. Study explores how emotions elicited by chewing gum affect ... Cellular safety shelters allow TB agent to survive in infected individuals. "Foamy" macrophage formation may be the key to ... Citation: Cellular safety shelters allow TB agent to survive in infected individuals (2008, November 14) retrieved 28 November ...
Title : The relevance of Yoruba medicine men in public health practice in Nigeria. Personal Author(s) : Ademuwagun, Z. A. ... Contraceptive Agents Family Planning Services Female Follow-Up Studies Hemorrhage Humans Injections, Intramuscular ... Title : Parenteral medroxyprogesterone as a contraceptive agent. Personal Author(s) : Scutchfield, F. Douglas;Long, W. Newton; ... Contraceptive use patterns, prior source, and pregnancy history of female family planning patients : United States, 1980 Cite ...
... coriacea seeds may be further studied to determine whether these seeds can be used as a possible male contraceptive agent. ... Because male infertility and male contraception can be regarded to be the same, the negative effects of B. ... Twenty five adult male Wistar rats (180-200 g) were housed in well-ventilated wire mesh cages in the Animal House of the ... Antifertility activity of Quassia amara in male rats: in vivo study. Life Sci. 1997;61(11):1067-1074.; Faisal et al., 20069. ...
"Time course of inhibition of caffeine elimination in response to the oral depot contraceptive agent Deposiston. Hormonal ... Caffeine overdose in an adolescent male. J Toxicol Clin Toxicol. Retrieved on 2006-08-14. ... Psychoanaleptics: psychostimulants, agents used for ADHD and nootropics (N06B). Centrally acting sympathomimetics. Amphetamine ... In women taking oral contraceptives this is increased to 5-10 hours,[31] and in pregnant women the half-life is roughly 9-11 ...
Phase I, II, III, or IV clinical trials to evaluate the safety and efficacy of new contraceptive methods for women and men ... Analyzing long-term health effects, including effects on the prostate and on bone mass, of new agents for male contraception ... Developing targeted nonhormonal contraceptive methods with minimal side effects. *Identifying specific hormonal agents, ... It has responsibility for discovery, development, and evaluation of contraceptive agents.. The CRB uses a combination of grants ...
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When joint effects of longer term use of both agents were considered, subjects who reported use of oral contraceptives for 10 ... Male circumcision (MC) is a key HIV prevention intervention for men in countries with high HIV prevalence. Womens ... Females were tested significantly more often than males and received testing more often in outpatient clinics whereas males ... this study found that nearly six times as many white men and women were prescribed PrEP as were black men and women. The ...
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  • Tobacco use - Older but pre-menopausal women who are smokers, particularly those that take oral contraceptive agents, have a twentyfold increased risk of heart attack. (sjchs.org)
  • Phenytoin, oral contraceptive agents, and calcium channel blockers may cause gingival hyperplasia. (medscape.com)
  • Modern methods of contraception include oral contraceptives (such as birth control pills), contraceptive vaginal rings, condoms, intrauterine devices (also called IUDs), injectable and implantable products, and sterilization. (nih.gov)
  • Participants with pregnant partners should use condoms during vaginal intercourse through 24 weeks after investigational agent administration. (who.int)
  • Contraceptive vaginal ring - Hormones are absorbed directly by the reproductive organs. (medscape.com)
  • The chemicals could serve as an emergency contraceptive taken either before or after intercourse, or as a permanent contraceptive via a skin patch or vaginal ring, say researchers at the University of California, Berkeley. (berkeley.edu)
  • Combined oral contraceptives, or COCs, are drugs that affect a woman's body with the help of hormones. (unmcrh.org)
  • The male birth control method lowers levels of testosterone and other hormones in the blood, cutting down on sperm production. (mobilephoneminers.com)
  • Lishko and her lab colleagues study male and female reproduction, including the hormones that trigger hyperactivity in sperm. (berkeley.edu)
  • details how a compound called EP055 binds to sperm proteins to significantly slow the overall mobility of the sperm without affecting hormones, making EP055 a potential "male pill" without side effects. (labmanager.com)
  • There are hormonal drugs in clinical trials that target the production of sperm, but these affect the natural hormones in men much like female contraceptives affect hormones in women. (labmanager.com)
  • Moore focused on the role of hormones on sex differentiation in offspring, the optimal conditions for sperm production, and the effects of vasectomy or testicular implants on male sex hormone production. (asu.edu)
  • Oral contraceptives containing a combination of estrogen and progestin increase sex hormone-binding globulin (SHBG) levels and thereby reduce the free testosterone level. (medscape.com)
  • Male estrogen levels that are methylprednisolone acetate on proteoglycan metabolism its fat-burning effects, but also its side effects. (aviarynyc.com)
  • It is a contraceptive combined estrogen-progestin drug. (unmcrh.org)
  • It is a monophasic hormonal oral contraceptive containing a combination of an estrogen (ethinyl estradiol) and progestogen (desogestrel) (150 mcg/20 mcg). (unmcrh.org)
  • The estrogen component is synthetic estrogen ethinyl estradiol, which increases the contraceptive effect of levonorgestrel. (unmcrh.org)
  • o Menopause as well as aging - The hormonal agents that motivate hair development progressively diminish throughout menopause and also the absence of estrogen in the scalp can result in an excess of DHT or Dihydrotestosterone. (lattenzione.com)
  • Combination patch contraceptive - Releases estrogen and progesterone directly into the skin. (medscape.com)
  • Dental birth controls or contraceptive tablets are composed of a tablet with dosages of artificial hormonal agents like progestin or estrogen, taken by mouth by a female to stop maternity. (zqhgz.com)
  • Because human spermatozoa contain PPP3CC and PPP3R2 as a form of calcineurin, inhibition of this sperm-specific calcineurin may lead to the development of a reversible male contraceptive that would target spermatozoa in the epididymis. (nih.gov)
  • The organization provides funding and advocacy support for the development of new methods of non-hormonal, reversible male contraceptives in order to empower men and couples with the resources they need to meaningfully and equitably contribute to family planning goals. (malecontraceptive.org)
  • We fund the research and development of new non-hormonal, reversible male contraceptives. (malecontraceptive.org)
  • A reversible male birth control that impacts the head of the sperm, preventing it from fertilizing an egg. (malecontraceptive.org)
  • An oral contraceptive containing ethinyl estradiol and a progestin with minimal androgenic activity, such as norgestimate, norethindrone, or desogestrel, should be selected. (medscape.com)
  • Contraceptive action is enhanced by ethinyl estradiol. (unmcrh.org)
  • There are currently 12 types of contraceptives readily available for women, while there are only two for men - condoms and vasectomies. (fox9.com)
  • Because these two plant compounds block fertilization at very, very low concentrations - about 10 times lower than levels of levonorgestrel in Plan B - they could be a new generation of emergency contraceptive we nicknamed 'molecular condoms,'" said Polina Lishko, an assistant professor of molecular and cell biology, who led the team that discovered the anti-fertility properties of the two chemicals. (berkeley.edu)
  • Currently, condoms and surgical vasectomy are the only safe forms of birth control currently available for men. (labmanager.com)
  • The contraceptive effect is achieved due to a number of factors, the most important of which are inhibition of ovulation and changes in the cervical mucus viscosity. (unmcrh.org)
  • The contraceptive effect of combined oral contraceptives is not based on the interaction of various factors, the most important of which are the suppression of ovulation and changes in the properties of the cervical secretion. (unmcrh.org)
  • Recent incidence of complications with the intrauterine device (IUD) and the contraceptive pill has led women throughout the world to revert to reusable cervical contraceptive pessaries such as the diaphragm and other related cervical pessaries such as the cervical cap, the vault cap, and the vimule. (justia.com)
  • It provides a disposable cervical barrier made chiefly of plastic foam, preferably polyurethane foam, that is preimpregnated with medicament, such as spermicide, germicide, or an abortion inducing agent, that is activated by contact with a small amount of water or any aqueous solution, including internal secretions. (justia.com)
  • It is accordingly a primary object of the present invention to provide a disposable cervical pessary device and a method of producing the same that will avoid the above drawbacks of present contraceptive devices. (justia.com)
  • It is thus an object of the present invention to provide a device and a method according to which a disposable contraceptive intravaginal cervical barrier can be produced that has a foam plastic member that is impregnated with a medicament such as spermicide, germicide, or an abortion inducing agent that is activatable upon contact with an aqueous solution. (justia.com)
  • Spermicidal agent - Prevents sperm from entering the cervical os by attacking the sperm's flagella and body, reducing their mobility, and disrupting their fructolytic activity, thereby inhibiting their nourishment. (medscape.com)
  • these contraceptives also alter the consistency of cervical mucus, affect the endometrial lining, and alter tubal transport. (medscape.com)
  • MDM2 polymorphism associated with the development of cervical lesions in women infected with Human papillomavirus and using of oral contraceptives. (cdc.gov)
  • Similar to intrauterine devices (IUDs) for women, Contraline's contraceptive is designed to last for years and be reversible. (malecontraceptive.org)
  • We demonstrate herein that male mice lacking Ppp3cc or Ppp3r2 genes (knockout mice) are infertile, with reduced sperm motility owing to an inflexible midpiece. (nih.gov)
  • Besides our current studies using a mouse model, we are analyzing the role of TSSKs in human sperm physiology, and applying this knowledge to male infertility in humans, in collaboration with the Baystate Medical Center Reproductive Biology Lab . (umass.edu)
  • While the advent of new assisted reproductive technologies, especially intracytoplasmic sperm injection (ICSI), has alleviated the number of cases of untreatable male infertility, the molecular defect(s) that impair sperm function is largely unknown. (umass.edu)
  • Single daily oral doses of triptonide induce altered sperm having minimal or no forward motility with close to 100% penetrance and consequently male infertility in 3-4 and 5-6 weeks. (scitechdaily.com)
  • The methanolic extract of Buchholzia coriacea seeds (MEBC) has been reported to induce male reproductive toxicity by decreasing sperm parameters and fertility index. (scielo.br)
  • Participants should refrain from sperm donation for 24 weeks after investigational agent administration (BRII-196/BRII-198, AZD7442 [IV], AZD7442 [IM], SAB-185). (who.int)
  • Two chemicals found in anti-fertility folk medicines block a key step in fertilization - the meeting of egg and sperm - and may make effective alternatives to today's hormone-based contraceptives, which sometimes cause side effects. (berkeley.edu)
  • During the study, 30 hours following a high-dose intravenous infusion of EP055 in male rhesus macaques, O'Rand and researchers in the Oregon National Primate Research Center at OHSU in Portland, Oregon, found no indication of normal sperm motility. (labmanager.com)
  • Male Contraceptive Initiative (MCI) supports the research & development of new birth control methods for men and sperm-producers. (malecontraceptive.org)
  • Results: Dose of ethyl acetate fraction (5 mg/ 100 g body weight) focused significant negative deviation in spermatogenesis, androgenesis and decreased germ cells numbers at different generations with decreased seminiferous tubular diameter along with increased numbers of programmed death of sperm cells in Wistar strain male rats. (ijfans.org)
  • PARTICIPANTS/MATERIALS, SETTING, METHODS This study included 2997 men, of whom 664 reported 893 recent pregnancies (in the 5 years preceding the survey). (elsevier.com)
  • The more contraceptive methods available, the better, as we will want a family of pharmaceutical products to safely and effectively meet the family planning needs of men and couples at different stages of their reproductive lives, with differing ethnic, cultural, and religious backgrounds and economic means," emphasized Wang and Swerdloff. (scitechdaily.com)
  • Male condom - One of the most popular mechanical barriers and, among all of the barrier methods, the one that provides the most effective protection of the genital tract from sexually transmitted diseases (STDs). (medscape.com)
  • Additionally, we promote the field of male contraception and provide people with the educational resources necessary to understand how the new male birth control methods will function, as well as the positive impact they will have on the world. (malecontraceptive.org)
  • We advocate for the research and development of new methods of male birth control. (malecontraceptive.org)
  • Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies. (marycrowley.org)
  • In a 2019 survey from the Male Contraceptive Initiative, 70% of men aged 18 to 44 said, 'they are very or somewhat interested in new male contraception. (fox9.com)
  • The World Health Organization (WHO) convened a Guideline Development Group (GDG) meeting from 29 to 31 July 2019 to review global guidance on contraceptive eligibility for women at high risk of HIV acquisition to and determine whether revisions to the fifth edition of the Medical eligibility criteria for. (bvsalud.org)
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  • Pregnancy must be ruled out before oral contraceptive therapy is started. (medscape.com)
  • however, little is known about factors associated with men's pregnancy intentions and associated contraceptive behaviours. (elsevier.com)
  • MAIN RESULTS AND THE ROLE OF CHANCE Of all heterosexually active men, 5% reported they had experienced an unintended pregnancy with a partner in the last 5 years. (elsevier.com)
  • Among all heterosexually active men, recent experience of an unintended pregnancy was related to age, mother's education, age at first sex, parity, contraceptive method history, lifetime number of female partners and the relationship situation at the time of survey. (elsevier.com)
  • 58% of contraceptive users considered that the pregnancy was due to inconsistent use and 39% considered that it resulted from method failure. (elsevier.com)
  • Half of the non-users who reported an unintended pregnancy thought that their partner was using a contraceptive method. (elsevier.com)
  • The relative risk of non-use of a contraceptive method during the month of conception of a recent unintended pregnancy was higher among those without a high school degree (IRR = 2.9, CI 1.6, 5.2) and higher among men for whom the pregnancy interfered with education (IRR = 1.8, CI 1.0, 3.1) or work (IRR = 1.9, CI 1.1, 3.6). (elsevier.com)
  • LIMITATIONS, REASONS FOR CAUTION From the perspective of men, the unintended pregnancy rates may be underestimated due to a combination of underreporting of abortion and post-rationalization of birth intentions. (elsevier.com)
  • To a wide extent, contraception is the effects on the body of a woman or a man, which make it possible to prevent conception, terminate a new pregnancy and thereby prevent the birth of an unwanted child. (unmcrh.org)
  • The term "contraceptives" refers to pharmacological agents that prevent pregnancy. (unmcrh.org)
  • Participants that engage in sexual activity that may lead to pregnancy in their partner must agree to either remain abstinent or use male contraceptives. (who.int)
  • Men may actually have a higher overall risk of thrombosis than women, but women have risks due to pregnancy, birth control and postmenopausal hormone. (mobilephoneminers.com)
  • A single injection that ensures a man cannot cause a pregnancy for years and is completely reversible. (malecontraceptive.org)
  • I'd like to welcome you to today's COCA call, Updated Interim Zika Clinical Guidance for Pregnant Women in Data on Contraceptive Use to Decrease Zika-Affected Pregnancy. (cdc.gov)
  • You're wanting a contraceptive that works on men and women? (halfbakery.com)
  • Compounding the problem of this formidable disease is how differently it can present itself in women as compared to men (heart disease is also men's number one killer) and the challenges brought about by these differences in diagnosis and treatment. (sjchs.org)
  • Diabetes - A much more powerful predictor of heart disease development in women than in men, with cardiovascular mortality rates about 3 times higher for women than men with diabetes. (sjchs.org)
  • Hypertension - In the elderly population, this is a stronger predictor of heart disease for women than for men. (sjchs.org)
  • Cholesterol - Women typically have higher HDL's (good portion of cholesterol) longer than men. (sjchs.org)
  • Obesity - In the United States, adult women have a higher incidence of obesity than males. (sjchs.org)
  • Symptoms of cardiovascular disease typically manifest for women about ten years later, on the average, than their male counterparts. (sjchs.org)
  • The mortality rates for women and men who have had revascularization become similar about a year following procedures," Hanna says. (sjchs.org)
  • The most heartbreaking part of the vanity fair article are the accounts of women who never knew that the contraceptive ring delivered a higher. (mobilephoneminers.com)
  • Men and women, but some people may produce it in higher amounts. (mobilephoneminers.com)
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  • This hormone is just one of the leading reasons for losing hair in both men and women, due to the fact that it cuts off the oxygen circulation (and also nutrition) to the hair follicle as well as virtually suffocates the root. (lattenzione.com)
  • The demand for male birth control exists, and a majority of women would trust their male partner to take the responsibility of taking contraception in their relationship. (malecontraceptive.org)
  • In either case, the best strategies for preventing PID are: a) prevention of lower-genital-tract infection with Chlamydia trachomatis and Neisseria gonorrhoeae among both men and women, b) when this fails, early detection of lower-tract infection followed by prompt and effective treatment. (cdc.gov)
  • We examined the transmission of human papillomavirus (HPV) in 25 heterosexual, monogamous couples (25 men, 25 women), followed up over an average of 7.5 months. (cdc.gov)
  • Men are assumed to be the main reservoirs of genital HPV infection for women, although comparatively little is known about the natural history of HPV in men. (cdc.gov)
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  • Some of these women drink alcohol with the foreign fishermen and also engage in sex with local men. (who.int)
  • Excessive alcohol consumption is prevalent among both men and women, which may lead to sexual assault. (who.int)
  • For HIV-positive heterosexual men and women, taking ART regularly greatly reduces the risk of HIV transmission to an HIV-negative partner. (cdc.gov)
  • However, the use of oral contraceptives may be associated with an increased risk of thrombosis and metabolic abnormalities. (medscape.com)
  • Gingival bleeding may occur with the use of anticoagulants and fibrinolytic agents. (medscape.com)
  • After men took the dmau pill. (mobilephoneminers.com)
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  • Katharine Dexter McCormick, who contributed the majority of funding for the development of the oral contraceptive pill, was born to Josephine and Wirt Dexter on 27 August 1875 in Dexter, Michigan. (asu.edu)
  • Also, because the chemicals prevent fertilization, they may be a more acceptable alternative in the eyes of those who object to emergency contraceptives, such as Plan B, that prevent the implantation of a potentially viable fertilized egg. (berkeley.edu)
  • Simply put, the compound turns-off the sperm's ability to swim, significantly limiting fertilization capabilities," said lead investigator Michael O'Rand, PhD, retired professor of cell biology and physiology in the University of North Carolina at Chapel Hill School of Medicine , and president/CEO of Eppin Pharma, Inc. "This makes EP055 an ideal candidate for non-hormonal male contraception. (labmanager.com)
  • The concomitant use of darifenacin extended-release tablets with other anticholinergic agents may increase the frequency and/or severity of dry mouth, constipation, blurred vision and other anticholinergic pharmacological effects. (nih.gov)
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  • People with schizophrenia and other neuropsychiatric disorders are especially vulnerable to the development of TDs after exposure to conventional neuroleptics, anticholinergics, toxins, substances of abuse, and other agents. (medscape.com)
  • There are several alternative approaches of birth control readily available in the market, the most frequently made use of approaches are contraceptive tablets and also prophylactics. (zqhgz.com)
  • Background: Herbal treatment is one of the approaches of male contraceptives though its molecular action is not properly known. (ijfans.org)
  • Calcineurin inhibitors, such as cyclosporine A and FK506, are used as immunosuppressant drugs, but their adverse effects on male reproductive function remain unclear. (nih.gov)
  • The characterization of TSSKs and the determination of TSSK inhibitors have the potential to lead to new advancements in male infertility and drug development. (umass.edu)
  • specific inhibitors of these enzymes will reversibly block reproduction and therefore constitute ideal candidates for a non-hormonal male contraceptive agent. (umass.edu)
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  • Dr. Berry-Bibee has been working as a full-time guest researcher in the Division of Reproductive Health at the CDC, working on recent updates to both the World Health Organization's and the CDC's medical eligibility criteria for contraceptive use and selected practice recommendations for contraceptive use. (cdc.gov)
  • The Pope also declared that this teaching about the use of marriage, "often set forth by the Magisterium, is founded upon the inseparable connection, willed by God and unable to be broken by man on his own initiative, between the two meanings of the conjugal act: the unitive meaning and the procreative meaning" ( Humane Vitae , 12). (ewtn.com)
  • Male Contraceptive Initiative (MCI) is a 501(c)(3) non-profit organization based in Durham, North Carolina, and founded in 2014. (malecontraceptive.org)
  • Male Contraceptive Initiative supports science that moves male contraceptives forward. (malecontraceptive.org)
  • Contraceptive Accelerator Network (CAN) works in parallel with Male Contraceptive Initiative to identify appropriate programs to support through the testing and evaluation processes required prior to Investigational New Drug (IND)-enabling studies and clinical trials. (malecontraceptive.org)
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