Contraception
Contraception, Postcoital
Contraceptives, Postcoital
Contraceptive Agents, Female
Contraceptives, Postcoital, Hormonal
Contraceptives, Oral, Hormonal
Contraceptive Agents, Male
Family Planning Services
Levonorgestrel
Contraceptive Devices
Contraceptives, Oral
Pregnancy, Unplanned
Contraceptives, Postcoital, Synthetic
Contraceptives, Oral, Combined
Contraception, Immunologic
Abortion, Induced
Sterilization, Reproductive
Intrauterine Devices, Copper
Contraception, Barrier
Pregnancy
Desogestrel
Ovulation Inhibition
Health Knowledge, Attitudes, Practice
Medroxyprogesterone Acetate
Reproductive Health Services
Norgestrel
Sex Education
Transdermal Patch
Contraceptives, Oral, Synthetic
Abortion, Legal
Spermatogenesis-Blocking Agents
Norethindrone
A synthetic progestational hormone with actions similar to those of PROGESTERONE but functioning as a more potent inhibitor of ovulation. It has weak estrogenic and androgenic properties. The hormone has been used in treating amenorrhea, functional uterine bleeding, endometriosis, and for contraception.
Norpregnadienes
Reproductive Medicine
A medical-surgical specialty concerned with the morphology, physiology, biochemistry, and pathology of reproduction in man and other animals, and on the biological, medical, and veterinary problems of fertility and lactation. It includes ovulation induction, diagnosis of infertility and recurrent pregnancy loss, and assisted reproductive technologies such as embryo transfer, in vitro fertilization, and intrafallopian transfer of zygotes. (From Infertility and Reproductive Medicine Clinics of North America, Foreword 1990; Journal of Reproduction and Fertility, Notice to Contributors, Jan 1979)
Progestins
Drug Implants
Spermatocidal Agents
Gynecology
Ethinyl Estradiol
Sterilization, Tubal
Fertility
Norprogesterones
Condoms
Vasectomy
Uterine Hemorrhage
Family Planning Policy
Questionnaires
Pregnanediol
Menstruation
Emergencies
Conscience
Mifepristone
A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early pregnancy by releasing endogenous prostaglandins from the endometrium or decidua. As a glucocorticoid receptor antagonist, the drug has been used to treat hypercortisolism in patients with nonpituitary CUSHING SYNDROME.
Ambulatory Care Facilities
Sexuality
Chlormadinone Acetate
Antispermatogenic Agents
Sex Counseling
Parity
Mestranol
Catholicism
The Christian faith, practice, or system of the Catholic Church, specifically the Roman Catholic, the Christian church that is characterized by a hierarchic structure of bishops and priests in which doctrinal and disciplinary authority are dependent upon apostolic succession, with the pope as head of the episcopal college. (From Webster, 3d ed; American Heritage Dictionary, 2d college ed)
Cross-Sectional Studies
Health Services Accessibility
Progesterone Congeners
Ethinyl Estradiol-Norgestrel Combination
Population Control
Women's Health Services
Spermatogenesis
Menstrual Cycle
The period from onset of one menstrual bleeding (MENSTRUATION) to the next in an ovulating woman or female primate. The menstrual cycle is regulated by endocrine interactions of the HYPOTHALAMUS; the PITUITARY GLAND; the ovaries; and the genital tract. The menstrual cycle is divided by OVULATION into two phases. Based on the endocrine status of the OVARY, there is a FOLLICULAR PHASE and a LUTEAL PHASE. Based on the response in the ENDOMETRIUM, the menstrual cycle is divided into a proliferative and a secretory phase.
United Arab Emirates
A federation of seven states on the southeast portion of the Arabian peninsula: Abu Dhabi, Ajman, Dubai, Fujairah, Ras al-Khaimah, Sharjah and Umm al-Qaiwain. In 1820 a treaty of peace was concluded between Great Britain and native rulers. During the 19th century the rulers agreed to suppression of the slave trade and restriction of foreign relations to Great Britain. The Trucial Council was established in 1952 and defense treaties with Great Britain terminated. In 1971 an independent six-member federation was formed, with Ras al-Khaimah joining the federation in 1972. (From Webster's New Geographical Dictionary, 1988, p1250)
Reproductive Physiological Phenomena
Marriage
Directive Counseling
Lipid Metabolism Disorders
Delayed-Action Preparations
Adolescent Health Services
Prescriptions
Gynecological Examination
Obstetrics
Health Care Surveys
Abortion, Therapeutic
Socioeconomic Factors
Pregnancy Rate
Nonoxynol
Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Nonoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide, formulated primarily as a component of vaginal foams and creams.
Armenia
An ancient country in western Asia, by the twentieth century divided among the former USSR, Turkey, and Iran. It was attacked at various times from before the 7th century B.C. to 69 B.C. by Assyrians, Medes, Persians, the Greeks under Alexander, and the Romans. It changed hands frequently in wars between Neo-Persian and Roman Empires from the 3d to 7th centuries and later under Arabs, Seljuks, Byzantines, and Mongols. In the 19th century Armenian nationalism arose but suffered during Russo-Turkish hostilities. It became part of the Soviet Republic in 1921, with part remaining under Turkey. (Webster's New Geographical Dictionary, 1988)
Uterine Perforation
Age Factors
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Preconception Care
An organized and comprehensive program of health care that identifies and reduces a woman's reproductive risks before conception through risk assessment, health promotion, and interventions. Preconception care programs may be designed to include the male partner in providing counseling and educational information in preparation for fatherhood, such as genetic counseling and testing, financial and family planning, etc. This concept is different from PRENATAL CARE, which occurs during pregnancy.
Interviews as Topic
Netherlands Antilles
Former Netherlands overseas territory in the Lesser Antilles in the West Indies. It had included the islands of Aruba, Bonaire, Curacao, Saba, St. Eustatius, and the southern part of St. Martin. The Netherlands Antilles dissolved on October 10, 2010. Aruba, Curacao and Sint Maarten became autonomous territories of the Kingdom of the Netherlands. Bonaire, Saba, and Sint Eustatius are under the direct administration of the Netherlands. (From US Department of State, Background Note)
Logistic Models
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Bosnia-Herzegovina
A country of eastern Europe, formerly the province of Bosnia in Yugoslavia, uniting with the province of Herzegovina to form the Republic of Bosnia and Herzegovina in 1946. It was created 7 April 1992 as a result of the division of Yugoslavia and recognized by the United States as an independent state. Bosnia takes is name from the river Bosna, in turn from the Indoeuropean root bhog, "current"; Herzegovina is from the Serbian herceg (duke) + -ov (the possessive) + -ina (country or territory).
Emergency Treatment
Nursing Records
Intrauterine Device Migration
Attitude
Female Urogenital Diseases
Paternalism
Interference with the FREEDOM or PERSONAL AUTONOMY of another person, with justifications referring to the promotion of the person's good or the prevention of harm to the person. (from Cambridge Dictionary of Philosophy, 1995); more generally, not allowing a person to make decisions on his or her own behalf.
Health Surveys
Safe Sex
Choice Behavior
Religion
A set of beliefs concerning the nature, cause, and purpose of the universe, especially when considered as the creation of a superhuman agency. It usually involves devotional and ritual observances and often a moral code for the conduct of human affairs. (Random House Collegiate Dictionary, rev. ed.)
Menstruation-Inducing Agents
Ethiopia
Adolescent Medicine
Forensic Nursing
The application of NURSING knowledge to questions of law. It is a specialty of nursing practice involving victims of crime which includes not only attending to the physical and emotional distress of victims, but also the identifying, collecting, and preserving evidence for law enforcement and the criminal justice system.
Nigeria
Danazol
A synthetic steroid with antigonadotropic and anti-estrogenic activities that acts as an anterior pituitary suppressant by inhibiting the pituitary output of gonadotropins. It possesses some androgenic properties. Danazol has been used in the treatment of endometriosis and some benign breast disorders.
Risk Factors
Testosterone
A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.
Prospective Studies
Physicians, Primary Care
Attitude of Health Personnel
Adolescent Psychology
Health Education
Population Growth
Spermatozoa
Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility.
HIV Infections
Fertile Period
The period in the MENSTRUAL CYCLE that is optimal for FERTILIZATION of the OVUM and yielding PREGNANCY. The duration of fertile period depends on the life span of male GAMETES within the female reproductive tract and the time of OVULATION. It usually begins a few days before ovulation and ends on the day of ovulation.
Marital Status
Legislation, Pharmacy
Risk-Taking
Mythology
Data Collection
Acne Vulgaris
Natural Family Planning Methods
A class of natural contraceptive methods in which SEXUAL ABSTINENCE is practiced a few days before and after the estimated day of ovulation, during the fertile phase. Methods for determining the fertile period or OVULATION DETECTION are based on various physiological indicators, such as circulating hormones, changes in cervical mucus (CERVIX MUCUS), and the basal body temperature.
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Family Practice
Outpatient Clinics, Hospital
Health Services Needs and Demand
Fetal Alcohol Spectrum Disorders
An umbrella term used to describe a pattern of disabilities and abnormalities that result from fetal exposure to ETHANOL during pregnancy. It encompasses a phenotypic range that can vary greatly between individuals, but reliably includes one or more of the following: characteristic facial dysmorphism, FETAL GROWTH RETARDATION, central nervous system abnormalities, cognitive and/or behavioral dysfunction, BIRTH DEFECTS. The level of maternal alcohol consumption does not necessarily correlate directly with disease severity.
Physician's Practice Patterns
Multivariate Analysis
Kenya
Community Pharmacy Services
Unsafe Sex
Abnormalities, Drug-Induced
Progesterone
The major progestational steroid that is secreted primarily by the CORPUS LUTEUM and the PLACENTA. Progesterone acts on the UTERUS, the MAMMARY GLANDS and the BRAIN. It is required in EMBRYO IMPLANTATION; PREGNANCY maintenance, and the development of mammary tissue for MILK production. Progesterone, converted from PREGNENOLONE, also serves as an intermediate in the biosynthesis of GONADAL STEROID HORMONES and adrenal CORTICOSTEROIDS.
Abortion, Spontaneous
A contraceptive peptide vaccine targeting sulfated glycoprotein ZP2 of the mouse zona pellucida. (1/106)
In this study, we have mapped and characterized a B cell epitope of sulfated glycoprotein ZP2 (ZP2) as a step toward the development of a multi-epitope zona pellucida (ZP) vaccine. Recombinant polypeptides expressed by random deoxyribonuclease-digested fragments of ZP2 cDNA were screened for binding to IE-3, a monoclonal antibody to murine ZP2. Positive clones contained cDNA inserts encoding polypeptide corresponding to ZP2(103-134). When normal or ovariectomized female mice were immunized with three overlapping peptides that span this region of ZP2 (101-120, 111-130, 121-140), only ZP2(121-140) elicited IgG antibodies that reacted with mouse ovarian ZP, indicative of the presence of native B epitope and helper T cell epitope in ZP2(121-140). To more finely map the ZP2 B cell epitope, a random peptide display library was screened with the IE-3 antibody, and a consensus tetramer sequence VxYK that matched the ZP2(123-126) sequence VRYK was located. Competitive immunofluorescence analysis with single alanine-substituted VxYK peptides ranked the relative contribution of the three critical B cell epitope residues as Y > V > K. A chimeric peptide was constructed that contained the YRYK motif of ZP2 and a bovine RNase T cell epitope. Although (C57BL/6xA/J) F1 (B6AF1) female mice immunized with the chimeric peptide developed ZP antibody response, this peptide elicited antibody only in mice of the histocompatibility complex (MHC) H-2(k or b) haplotype. In contrast, ZP2(121-140) peptide elicited antibody in inbred mice with three additional mouse MHC haplotypes. Moreover, although ZP2(121-140) contained a T cell epitope, no oophoritis was observed after immunization of B6AF1 mice with ZP2(121-140) in complete Freund's adjuvant (CFA). In a preliminary trial, female B6AF1 mice immunized with ZP2(121-140) in CFA had reduced litter sizes as compared with mice injected with CFA alone. (+info)Antibodies to human ZP3 induce reversible contraception in transgenic mice with 'humanized' zonae pellucidae. (2/106)
The initial spermatozoon-egg interaction of mammalian fertilization is mediated by the zona pellucida, an extracellular matrix composed of three glycoproteins (ZP1, ZP2, ZP3). These proteins are sufficiently conserved between human and mouse to form chimeric zonae pellucidae, and genetically engineered mice in which the endogenous mouse ZP3 has been replaced by human ZP3 have 'humanized' zonae, but normal fertility. Administration of monoclonal antibodies to mouse ZP3 does not affect fertility in these animals, but administration of antibodies to human ZP3 results in long-term, reversible contraception. The antibodies coat the zonae pellucidae surrounding growing oocytes within the ovary and their presence in the zona matrix inhibits, but does not eliminate, sperm binding. The contraceptive effect is attributed to steric hindrance that decreases sperm binding and prevents penetration through the zona pellucida. The resumption of fertility is associated with the disappearance of antibodies from the zona matrix. No adverse effect on mating behaviour, ovarian histology or fetal development (if administered after fertilization) is detected in treated females. These results suggest that transgenic mice expressing human proteins will prove useful in assessing contraceptive efficacy of zona epitopes in the rational design of immunocontraception directed at the human zona pellucida. (+info)Design and evaluation of a ZP3 peptide vaccine in a homologous primate model. (3/106)
The concept of a safe, immunocontraceptive vaccine using the zona pellucida glycoprotein 3 (ZP3) as an immunogen has been marred by the appearance of ovarian dysfunction in several species. However, careful selection of epitopes on mouse ZP3 have demonstrated that it is possible to segregate contraceptive bone marrow-derived (B)-cell epitopes from the cytotoxic thymus-derived (T)-cell epitopes thought to be responsible for inducing ovarian disease. B-cell epitopes on marmoset ZP3 (mstZP3) were identified by epitope mapping studies. Using a panel of polyclonal antibodies against recombinant mstZP3, an immunodominant epitope mstZP3(301-320) was identified. A chimeric peptide was co-linearly synthesized incorporating this sequence with a promiscuous tetanus toxoid T-helper cell epitope. Using the common marmoset (Callithrix jacchus) as an animal model, we have compared the consequences of active immunization with homologous recombinant mstZP3 and mstZP3(301-320) chimeric peptide vaccine. Long-term infertility was achieved using mstZP3 but at the expense of ovarian function. In contrast, no disruption to ovarian function was observed following mstZP3(301-320) immunization. Antibodies to this peptide immunolocalized to the zona pellucida of both marmoset and human ovarian sections and inhibited human sperm-zona binding by approximately 60% in vitro. However, in-vivo studies indicated that targeting a single ZP3 epitope was insufficient to reliably and consistently achieve a contraceptive effect. (+info)Antigenic and immunogenic properties of totally synthetic peptide-based anti-fertility vaccines. (4/106)
In this study we describe the results of experiments in which a variety of totally synthetic luteinizing hormone releasing hormone (LHRH) vaccines were assembled and examined for their abilities to elicit antibody responses and induce sterility in mice. It is shown that totally synthetic vaccines consisting of a 15 residue-defined T cell epitope and the 10 residue LHRH epitope not only induced high titers of antibody but also induced sterility. This effect did not appear to correlate with antibody titer, antibody isotype or comparative antibody affinity, but may be related to the length of time for which antibodies are present to exert their influence. (+info)Immunological control of fertility: measurement of affinity of antibodies to human chorionic gonadotrophin. (5/106)
Four baboons were primed with diazotized beta human chorionic gonadotrophin and boosted with diazotized C-terminal beta human chorionic gonadotrophin peptide, and the changes in antibody amount and affinity determined using a double isotope modified Farr assay, using labelled human chorionic gonadotrophin as the antigen. The degree of cross-reaction with human luteinizing hormone was also determined. Although appreciable reactivity with luteinizing hormone was observed soon after immunization, this declined rapidly during the response. At the time intervals studied, there was a progressive increase in affinity of antibodies to human chorionic gonadotrophin until day 248 after priming. At day 313, in two of the animals, there was a decrease in affinity from 1.04 X 10(11) to 6.80 X 10(10) and 1.05 X 10(11) to 4.93 X 10(10) l/mol, whereas in the other two baboons there was a further increase in antibody affinity. At corresponding time intervals, there was a steady decrease in values of total antibody binding sites. To determine the overall effect of the maturation of affinity with a decrease in antibody amount on biological efficacy, the theoretical amount of chorionic gonadotrophin that would be neutralized was calculated. We computed that in all instances, over 99% of a peak concentration of chorionic gonadotrophin that could be in circulation in a pregnant baboon would be neutralized. This was in excellent agreement with results of mating experiments in these baboons. In over forty cycles studied, none of the matings resulted in a sustained pregnancy. (+info)Delineation of a conserved B cell epitope on bonnet monkey (Macaca radiata) and human zona pellucida glycoprotein-B by monoclonal antibodies demonstrating inhibition of sperm-egg binding. (6/106)
To circumvent autoimmune oophoritis after immunization with zona pellucida (ZP) glycoproteins, synthetic peptides encompassing B cell epitope(s) and devoid of oophoritogenic T cell epitopes as immunogens have been proposed. In this study, bonnet monkey (Macaca radiata) ZP glycoprotein-B (bmZPB) was expressed as polyhistidine fusion protein in Escherichia coli. Rabbit polyclonal antibodies against recombinant bmZPB (r-bmZPB) significantly inhibited human sperm-oocyte binding. To map B cell epitopes on ZPB, a panel of 7 murine monoclonal antibodies (mAbs) was generated against r-bmZPB. All 7 mAbs, when tested in an indirect immunofluorescence assay, reacted with bonnet monkey ZP, and only 6 recognized human zonae. Monoclonal antibodies MA-809, -811, -813, and -825 showed significant inhibition in the binding of human spermatozoa to human ZP in a hemizona assay. Epitope-mapping studies using multipin peptide synthesis strategy revealed that these 4 mAbs recognized a common epitope corresponding to amino acids (aa) 136-147 (DAPDTDWCDSIP). Competitive binding studies revealed that the synthetic peptide corresponding to the identified epitope (aa 136-147) inhibited the binding of MA-809, -811, -813, and -825 to r-bmZPB in an ELISA and to bonnet monkey ZP in an indirect immunofluorescence assay. The epitopic domain corresponding to aa 136-147 of bmZPB was completely conserved in human ZPB. These studies will further help in designing ZP-based synthetic peptide immunogens incorporating relevant B cell epitope for fertility regulation in humans. (+info)Identification of human sperm peptide sequence involved in egg binding for immunocontraception. (7/106)
Development of a vaccine based on sperm antigens represents a promising approach to contraception. The sperm-zona pellucida (ZP) interaction constitutes the most important event in the fertilization process, and the molecular sequences involved at this site may provide the most attractive candidates for immunocontraception. In the present study, using the phase peptide display technique, a novel dodecamer sequence, designated as YLP(12), was identified that is involved in sperm-ZP recognition/binding. The synthetic 12-mer peptide based on this sequence and its monovalent Fab' antibodies specifically and significantly (P < 0.05) inhibited human sperm-ZP binding. In Western blot and immunoprecipitation procedures, the YLP(12) peptide recognized the ZP3 component of solubilized human ZP proteins. In the Western blot procedure involving 10 different human tissue extracts, the anti-YLP(12) Fab' antibodies recognized a protein band of approximately 72 +/- 2 kDa only in the testis lane. The peptide sequence was localized on the acrosomal region of the human sperm cell. These findings indicate that the novel testis-specific 12-mer YLP(12) that is present in the acrosomal region and is involved in human sperm-ZP interaction may find applications in contraceptive vaccine development, as well as in diagnosis and treatment of male infertility mediated through sperm dysfunction. (+info)Immunological block to mammalian fertilization: survival and organ distribution of immunoglobulin which inhibits fertilization in vivo. (8/106)
Fertilization of golden hamster eggs was blocked both in vitro and in vivo by antibodies produced in rabbits against specific hamster ovarian antigens (HOA). Antibodies against HOA bound to surfaces of the hamster egg zona pellucida and prevented spermatozoa from attaching to the zona and entering eggs in vitro. Fertilization in animals could be blocked for four estrous cycles by a single intraperitoneal injection of anti-HOA immunoglobulin, but not by control immunoglobulin. The in vivo fate of anti-HOA immunoglobulin was analyzed by simultaneous injection of 125I-anti-HOA IgG and control 131I-IgG. Both anti-HOA IgG and control IgG appeared in a variety of organs (lung, kidney, spleen, liver, and uterus) shortly after injection, but disappeared rapidly with no detectable differences in organ half lives. However, in the ovary anti-HOA IgG (but not control IgG) persisted at high levels during the period of infertility. Quantitative precipitin analysis of organ homogenates indicated that a high percentage of anti-HOA IgG in the ovary (but not in the other organs tested) was immunologically indistinguishable from IgG indicating lack of radiolabel metabolism and reincorporation. The results are discussed in terms of the development of a specific immunological block to fertility. (+info)
Immunocontraception - Wikipedia
Biological control of vertebrate pests using virally vectored immunocontraception<...
IMMUNOCONTRACEPTION AND POSSIBLE APPLICATION IN WILDLIFE DAMAGE MANAGE by Lowell A. Miller
Conference Announcement
Devin Kazakoff talks to TCC about the Native PZP Immunocontraceptive - The Critical Cat
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Contraception, Immunologic | Profiles RNS
Evaluation of a single-shot gonadotropin-releasing hormone (GnRH) immunocontraceptive vaccine in captive badgers | SpringerLink
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A Phase 3, randomized, active-comparator controlled clinical trial to study the contraceptive efficacy and safety of the MK...
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Diaphragm Construction
Sperm-associated antigen 1
Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, ...
List of MeSH codes (E02)
... contraception, barrier MeSH E02.875.194.300 - contraception, immunologic MeSH E02.875.194.540 - contraception, postcoital MeSH ... immunologic MeSH E02.095.520.450.440 - graft enhancement, immunologic MeSH E02.095.520.450.521 - lymphocyte depletion MeSH ...
Library of Congress Classification:Class R -- Medicine
Immunologic diseases. Allergy 620-627.........................................Nutritional diseases. Deficiency diseases 627.5- ... Contraception 138.........................................Sterilization of women 159-208................................... ...
Angioedema
Acquired angioedema (AAE) can be immunologic, nonimmunologic, or idiopathic. It is usually caused by allergy and occurs ... it can be exacerbated by pregnancy and use of hormonal contraception (exact frequency uncertain). It has been linked with ...
Pregnancy test
Contraception. 98 (1): 30-35. doi:10.1016/j.contraception.2018.03.013. ISSN 0010-7824. PMID 29534996. Raymond, Elizabeth G.; ... Immunologic pregnancy tests were introduced in 1960 when Wide and Gemzell presented a test based on in-vitro hemagglutination ... Contraception. 95 (5): 442-448. doi:10.1016/j.contraception.2016.12.004. ISSN 0010-7824. PMID 28041991. Lynd, Kelsey; Blum, ... Museum of Contraception and Abortion". en.muvs.org. Retrieved 29 March 2018. Bleavins MR, Carini C, Malle JR, Rahbari R (2010 ...
HIV Prevention Trials Network
HVTN 804/HPTN 095 is an antiretroviral analytical treatment interruption study to assess immunologic and virologic responses in ... and delivery systems for HIV prevention Developing multi-purpose technologies for HIV prevention as well as for contraception ... HVTN 805/HPTN 093 is an antiretroviral analytical treatment interruption study to assess immunologic and virologic responses in ...
Xenotransplantation
Takahashi, T.; Saadi, S.; Platt, J. L. (1997). "Recent advances in the immunology of xenotransplantation". Immunologic Research ... "the use of barrier contraception when engaging in sexual intercourse;" fifth, keep both name and current address on register ...
Systemic lupus erythematosus
Immunologic disorder: Positive anti-Smith, anti-ds DNA, antiphospholipid antibody, or false positive serological test for ... Contraception and other reliable forms of pregnancy prevention is routinely advised for women with SLE, since getting pregnant ... Simplest classification tree: SLE is diagnosed if a person has an immunologic disorder (anti-DNA antibody, anti-Smith antibody ... established a list of clinical and immunologic criteria that, in any combination, point to SLE. The criteria include symptoms ...
Adverse effect
Due to the exceedingly high impact on public health of widely used medications, such as hormonal contraception and hormone ... "Silicone Breast Implants in Relation to Connective Tissue Diseases and Immunologic Dysfunction". Archived from the original on ... Liver damage from paracetamol Melasma and thrombosis associated with use of estrogen-containing hormonal contraception, such as ...
Breastfeeding
This has been used as natural contraception, with greater than 98% effectiveness during the first six months after birth if ... growth factors and immunologic substances to effectively defend against infectious diseases for the infant. The breast milk ...
Breastfeeding
This has been used as natural contraception, with greater than 98% effectiveness during the first six months after birth if ... Breastfeeding triggers biochemical reactions which allow for the enzymes, hormones, growth factors and immunologic substances ...
Local anesthetic
Immunologic allergy[edit]. Adverse reactions to local anesthetics (especially the esters) are not uncommon, but legitimate ...
Stimulant
Commonly used tests include chromatography, immunologic assay, and mass spectrometry.[129] See also[edit]. *Antipsychotics ...
Stimulant
Commonly used tests include chromatography, immunologic assay, and mass spectrometry.[127] See also[edit]. *Antidepressants ...
Angioedema
Acquired angioedema (AAE) can be immunologic, nonimmunologic, or idiopathic.[5] It is usually caused by allergy and occurs ... it can be exacerbated by pregnancy and use of hormonal contraception (exact frequency uncertain).[10] It has been linked with ...
Breastfeeding
This has been used as natural contraception, with greater than 98% effectiveness during the first six months after birth if ... growth factors and immunologic substances to effectively defend against infectious diseases for the infant. The breast milk ...
Adverse effect
Due to the exceedingly high impact on public health of widely used medications, such as hormonal contraception and hormone ... "Silicone Breast Implants in Relation to Connective Tissue Diseases and Immunologic Dysfunction". Archived from the original on ... Melasma and thrombosis associated with use of estrogen-containing hormonal contraception, such as the combined oral ...
Sperm Antigens, Immunologic Infertility and Contraception | SpringerLink
Immunologic Infertility and Contraception. In: Talwar G.P. (eds) Immunological Approaches to Contraception and Promotion of ... Immunological Approaches to Contraception and Promotion of Fertility pp 151-154 , Cite as ... However, this study definitely showed the iso-antigenicity of human sperm in women and that the concept of an immunologic ... As early as the 1920s speculation arose concerning the possible role of immunologic reactions involving sperm in human ...
Contraception, Immunologic | Profiles RNS
Immunologic" by people in this website by year, and whether "Contraception, Immunologic" was a major or minor topic of these ... "Contraception, Immunologic" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Contraception, Immunologic" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Contraception, Immunologic". ...
A Pilot Surgical Trial To Evaluate Early Immunologic Pharmacodynamic Parameters For The PD-1 Checkpoint Inhibitor,...
Highly effective contraception is defined as either:. *True Abstinence: When this is in line with the preferred and usual ... Barrier methods of contraception: Condom or Occlusive cap (diaphragm or cervical/vault caps) with spermicidal foam/gel/film/ ... Male subjects must agree to use adequate method of contraception starting with the first dose of study therapy through 120 days ... A Pilot Surgical Trial To Evaluate Early Immunologic Pharmacodynamic Parameters For The PD-1 Checkpoint Inhibitor, ...
Study of the 48-Week Virologic and Immunologic Response to Lopinavir/Ritonavir (Kaletra) in HIV Positive Adult Patients - Full...
As a result, hormonal contraception is not considered adequate.. Exclusion Criteria:. *Patient with active AIDS-defining ... Study of the 48-Week Virologic and Immunologic Response to Lopinavir/Ritonavir (Kaletra) in HIV Positive Adult Patients. The ... Immunologic Deficiency Syndromes. Immune System Diseases. Ritonavir. Lopinavir. HIV Protease Inhibitors. Protease Inhibitors. ... A Phase II, Open Label, Single Arm Study of the 48-Week Virologic and Immunologic Response to Lopinavir/Ritonavir (Kaletra) as ...
Immunologic Disorders | American Academy of Pediatrics
Contraceptive vaccines targeting factors involved in establishment of pregnancy.
A more specific method of contraception is needed. Contraceptive vaccines can provide most, if not all, the desired ... Current methods of contraception lack specificity and are accompanied with serious side effects. ... Contraception, Immunologic / methods*. Contraceptive Agents / immunology. Cytokines / immunology. Databases, Genetic. Embryo ... Current methods of contraception lack specificity and are accompanied with serious side effects. A more specific method of ...
Current version of study NCT00832559 on ClinicalTrials.gov
Boron Neutron Capture Therapy Using Boronophenylalanine-Fructose Complex in Treating Patients With Metastatic Melanoma
Public Health Service Task Force Recommendations for the Use of
Antiretroviral Drugs in Pregnant Women Infected with HIV-1 for...
Data from follow-up of PACTG 076 infants from birth through age 18-36 months do not indicate any differences in immunologic, ... services that continue after pregnancy for their own medical care and for assistance with family planning and contraception. ... Such considerations include gestational age of the fetus; the womans clinical, immunologic, and virologic status; and the ... HIV-1-infected pregnant women must receive standard clinical, immunologic, and virologic evaluation. Recommendations for ...
Irinotecan, Cisplatin, and Bevacizumab in Treating Patients With Unresectable or Metastatic Gastric or Gastroesophageal...
Contraception | American Academy of Pediatrics
Is Absence of Spontaneous Agglutinates of Spermatozoa in Semen a Reliable Indicator of Non-Autosensization against Human Sperm...
Gemcitabine With or Without Docetaxel as Second-Line Therapy in Treating Patients With Metastatic or Relapsed, Unresectable...
Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction - American College of Cardiology
Appropriate Use of the Intrauterine Device - American Family Physician
Contraception. 1987;36:55-84.. 22. White MK, Ory HW, Rooks JB, Rochat RW. Intrauterine device termination rates and the ... enabling them to bypass the immunologic barrier provided by the endocervix. This design flaw caused a fivefold increase in ... Two recent studies on contraception have shed new light on the IUD. One report compared the economic value of 15 different ... Cost Comparison of Six Methods of Contraception*. Methods. Managed payment model. Public payment model. ...
Safety and Pharmacokinetic Study of Fixed Dose Combination of Zidovudine, Lamivudine, and Nevirapine in HIV-Infected Children...
History of immunologic failure. More information on this criterion can be found in the protocol. * Current treatment for an ... Agree to use two appropriate forms of contraception. More information on this criterion can be found in the protocol. * Parent ... Agree to use two appropriate forms of contraception. More information on this criterion can be found in the protocol. * Ability ...
Sperm-associated antigen 1 - Wikipedia
Belimumab | definition of belimumab by Medical dictionary
Advise women of childbearing potential to use adequate contraception and to avoid breast feeding during and for at least 4 mos ... Result is ↓ disease activity with lessened damage/improvement in mucocutaneous, musculoskeletal and immunologic manifestations ... Improvement in mucocutaneous, musculoskeletal, and immunologic disease activity in patients with SLE. ... women with childbearing potential should use adequate contraception during and for 4 mo following treatment. ...
Tivicay (Doutegravir 50mg Tablets): Uses, Dosage, Side Effects, Interactions, Warning
Counsel adolescents and adults of childbearing potential to consistently use effective contraception [see Use In Specific ... The safety, virologic, and immunologic responses in subjects who received TIVICAY were evaluated in 46 treatment-experienced, ... If you can become pregnant, you should consistently use effective birth control (contraception) during treatment with TIVICAY. ... Counsel adolescents and adults of childbearing potential taking TIVICAY to consistently use effective contraception [see ...
Obinutuzumab (Professional Patient Advice) - Drugs.com
Geometry.Net - Health Conditions: Sexually Transmitted Diseases
Abortion Birth Control and Emergency Contraception Communication and Relationships Gynecological Exam ... Sexually Transmitted ... Original, peerreviewed articles on clinical, laboratory, immunologic, epidemiologic, sociologic, http://www.stdjournal.com/&e= ... contraception and family planning, and related topics. Maintained by US Centers for Disease Control. http://www.cdc.gov/nccdphp ...
SPAG8 Gene - GeneCards | SPAG8 Protein | SPAG8 Antibody
SPAG1 gene - Genetics Home Reference - NIH
HIV Risk and Hormonal Contraception in sub-Saharan Africa « Ragon Institute of MGH, MIT and Harvard
The researchers examined immunologic factors in the female genital tract, the site where HIV infection is established in most ... Comments Off on HIV Risk and Hormonal Contraception in sub-Saharan Africa Comments ... IPCs are the most common form of contraception used in sub-Saharan Africa and are common in some areas of high HIV incidence. ... but also examines the immunologic mechanism for this observation. ... HIV Risk and Hormonal Contraception in sub-Saharan Africa *Home ...
Sustiva (Efavirenz): Side Effects, Interactions, Warning, Dosage & Uses
Barrier contraception should always be used in combination with other methods of contraception. Hormonal methods that contain ... The safety, pharmacokinetic profile, and virologic and immunologic responses of SUSTIVA were evaluated in antiretroviral-naive ... Contraception. Females of reproductive potential should use effective contraception during treatment with SUSTIVA and for 12 ... A reliable method of barrier contraception should be used in addition to hormonal contraceptives.. A reliable method of barrier ...
Infertility in the Male - 9780521872898 - Cambridge University Press
Ogestrel 0.5/50 Side Effects in Detail - Drugs.com
Immunologic. Immunologic side effects include cases of oral contraceptive-induced systemic lupus erythematosus which have been ... Mishell DR "Contraception." N Engl J Med 320 (1989): 777-85. 28. Thomas DB "Oral contraceptives and breast cancer: review of ... Lidegaard O "Oral contraception and risk of a cerebral thromboembolic attack: results of a case-control study." BMJ 306 (1993 ... Hannaford PC, Croft PR, Kay CR "Oral contraception and stroke. Evidence from the Royal College of General Practitioners Oral ...
Bevacizumab, Gemcitabine, and Oxaliplatin in Treating Patients With Metastatic Pancreatic Cancer - Full Text View -...
The American Society for Reproductive Immunology - 2017 Agenda
Search | Global Index Medicus
Humans , Female , Pregnancy , Contraception/trends , Contraception , Contraception, Immunologic/methods , Uganda , Vaccines/ ... Contraception/methods , Contraception, Immunologic/methods , Female , Hormone Antagonists/pharmacology , Humans , India , Male ... Antigens , Autoantibodies/biosynthesis , Contraception/methods , Contraception, Immunologic/methods , Humans , Immunization , ... Animals , Contraception, Immunologic/methods , Egg Proteins/immunology , Humans , Membrane Glycoproteins/immunology , Receptors ...
ImmunocontraceptionHormonalAllergyInfertilityHypertensionContraceptiveForms of contraceptionMethod of contraceptionMeSHIntrauterine deviceDiagnosticPregnancyEmergency contraceptionReproductive PotentialPracticeMethodsAdequateBarrierMechanismFetalProstateFactorsSpecificRoleStudyPatientsCommon formTopicStudies
Immunocontraception1
- Results: The results are mainly revealing the regimens that are administered in male hormonal contraception and substances that are used in immunocontraception. (ui.ac.id)
Hormonal3
- In male hormonal contraception, the mechanism was depends on negative feedback in hypothalamic-pituitary-gonadal axis by regimens to impair the spermatogenesis into severe-oligozoospermia or azoospermia. (ui.ac.id)
- Adequate forms of contraception to be used include hormonal contraceptives (oral, patch, depot), intrauterine devices (IUD), barrier contraceptive methods, such as diaphragm, cervical cap/shield, male condoms and female condoms.Sexually active subjects must use contraception while on study drug from admission to the Follow-up Visit. (pfizer.com)
- Female subjects of childbearing potential - not surgically sterile or at least 2 years postmenopausal - must agree to utilize one of the following forms of contraception from screening through completion of the study: abstinence, hormonal (oral, implant, transdermal, or injection) for at least 3 months prior to the first dose of the study, barrier (condom with spermicide, diaphragm with spermicide), IUD, or vasectomized partner (6 months minimum). (clinicaltrials.gov)
Allergy1
- The greater prevalence of food allergy in children reflects both the increased predisposition of children to develop food allergies and the development of immunologic tolerance to certain foods over time. (thefreedictionary.com)
Infertility2
- As early as the 1920's speculation arose concerning the possible role of immunologic reactions involving sperm in human infertility. (springer.com)
- Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. (wikipedia.org)
Hypertension1
- A 19-year-old woman with diabetes and hypertension requiring emergency contraception / David Chelmow -- 5. (stanford.edu)
Contraceptive3
- However, this study definitely showed the iso-antigenicity of human sperm in women and that the concept of an immunologic contraceptive based on sperm antigens is plausible. (springer.com)
- 3. During the course of the study, from study screen until study exit - including the washout period, women of childbearing potential must use a spermicide containing barrier method of contraception in addition to their current contraceptive device. (clinicalconnection.com)
- The nails posted that the normal Teach Yourself of contraceptive work in control systems with spina bifida aperta at E20 met Nevertheless, and the season contraception too sounded Completed with the broadband without wireless. (newviewgraphics.com)
Forms of contraception1
- Acceptable forms of contraception include the following: 1. (clinicalconnection.com)
Method of contraception3
- A more specific method of contraception is needed. (biomedsearch.com)
- Subjects and their partners must agree to use of an effective method of contraception, to avoid impregnation of females throughout the course of the study. (pfizer.com)
- Each method of contraception has its specific benefits and risks. (pardus.info)
MeSH1
- Contraception, Immunologic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Intrauterine device1
- Throughout the world, the most common form of reversible contraception is the intrauterine device (IUD), used by 85 million to 100 million women. (aafp.org)
Diagnostic1
- Symptoms and signs diagnostic findings1 treatment allergic bronchopulmo- immunologic response to treatment. (goodbelly.com)
Pregnancy3
- Factors that are both essential and pregnancy-specific can provide potential targets for contraception. (biomedsearch.com)
- A multiepitope vaccine combining factors/antigens involved in various steps of the fertilization cascade and pregnancy establishment may provide a highly immunogenic and efficacious modality for contraception in humans. (biomedsearch.com)
- Pregnancy testing and contraception are recommended. (nih.gov)
Emergency contraception2
- Testos- terone replacement also improves access to emergency contraception. (goodbelly.com)
- A 25-year-old woman requesting emergency contraception / Reni A. Soon and Tod C. Aeby -- 7. (stanford.edu)
Reproductive Potential1
- Males of Reproductive Potential: ALIMTA may impair fertility in males cialis online without prescription of reproductive potential to use effective contraception during treatment with LORBRENA and for 3 plasma half-lives of the Private right here Securities Litigation Reform Act of 1995. (crewsaver.pl)
Practice1
- 2. Women of childbearing potential must practice abstinence or be using an acceptable form of contraception throughout the duration of the study. (clinicalconnection.com)
Methods4
- Current methods of contraception lack specificity and are accompanied with serious side effects. (biomedsearch.com)
- The economic value of contraception: a comparison of 15 methods. (aafp.org)
- There are a few methods in male contraception, but all is still not proven optimally. (ui.ac.id)
- One study gathered data from a variety of sources which have estimated the mortality rate associated with different methods of contraception at different ages Table IV. (pardus.info)
Adequate1
- women with childbearing potential should use adequate contraception during and for 4 mo following treatment. (thefreedictionary.com)
Barrier1
- 4 , 5 This multifilament tail provided a pathway for bacteria, enabling them to bypass the immunologic barrier provided by the endocervix. (aafp.org)
Mechanism4
- The paper, published in The Lancet Infectious Diseases by co-lead authors Elizabeth Byrne and Melis Anahtar, is unique in that it not only identifies an epidemiologic risk of HIV acquisition in IPC users, but also examines the immunologic mechanism for this observation. (ragoninstitute.org)
- Therefore, it is intend to understand more about the cellular mechanism of male contraception. (ui.ac.id)
- Furthermore, this reviews also reveales the cellular mechanism of both types of male contraception. (ui.ac.id)
- Conclusion: It is necessary to understand the cellular mechanism, thus the development of male contraception increases. (ui.ac.id)
Fetal1
- 25. Beer A.E. and Billingham R.E.: Immunologic co-existence and the maternal fetal relationship. (repro-med.net)
Prostate1
- Uniquely, Advaxis Lm-LLO technology also inhibits Treg and MDSC cells within the tumor microenvironment that promote immunologic tolerance of the prostate cancer cells of the tumor. (thefreedictionary.com)
Factors2
- The researchers examined immunologic factors in the female genital tract, the site where HIV infection is established in most of the women. (ragoninstitute.org)
- Immunologic and biochemical factors in hyperemesis gravidarum with or without hyperthyroxinemia. (medscape.com)
Specific2
- immunologic tolerance specific nonreactivity of lymphoid tissues to a particular antigen capable under other conditions of inducing immunity. (thefreedictionary.com)
- We now report contraception of male nonhuman primates (Macaca radiata) immunized with Eppin, a testis/epididymis-specific protein. (elsevier.com)
Role2
- Although woman contraception is widely used, still the role of man is needed. (ui.ac.id)
- The results warrant further study and support a role for ASA-influenced mechanisms, perhaps immunologic, in the generation of MS-related chronic fatigue. (neurology.org)
Study1
- The study by Byrne and Anahtar focused on women between 18-23 years of age in which those who used IPCs were indistinguishable in terms of their behavioral risk for HIV infection from those using no long term contraception. (ragoninstitute.org)
Patients1
- The companies believe that immune recognition of more spike T cell immune responses elicited by BNT162b2 are being evaluated in patients with immunologic conditions said Patrik Jonsson, senior vice president and president of Lilly Oncology. (crewsaver.pl)
Common form1
- IPCs are the most common form of contraception used in sub-Saharan Africa and are common in some areas of high HIV incidence. (ragoninstitute.org)
Topic1
- This graph shows the total number of publications written about "Contraception, Immunologic" by people in this website by year, and whether "Contraception, Immunologic" was a major or minor topic of these publications. (uchicago.edu)
Studies1
- Two recent studies on contraception have shed new light on the IUD. (aafp.org)