Containment of Biohazards
Cost Control
Quarantine
Legg-Calve-Perthes Disease
Disease Outbreaks
Single-Payer System
Patient Isolators
Smallpox
Medical Waste
Ventilation
Hazardous Substances
Dracunculus Nematode
Bioterrorism
Aerosols
Environment, Controlled
Insurance, Hospitalization
Dracunculiasis
Genetic Engineering
Patient Isolation
Infection Control
Air Microbiology
Plant Infertility
Communicable Disease Control
Medical Laboratory Science
Poliomyelitis
Air evacuation under high-level biosafety containment: the aeromedical isolation team. (1/121)
Military contingency operations in tropical environments and potential use of biological weapons by adversaries may place troops at risk for potentially lethal contagious infections (e.g., viral hemorrhagic fevers, plague, and zoonotic poxvirus infections). Diagnosis and treatment of such infections would be expedited by evacuating a limited number of patients to a facility with containment laboratories. To safely evacuate such patients by military aircraft and minimize the risk for transmission to air crews, caregivers, and civilians, the U.S. Army Medical Research Institute of Infectious Diseases maintains an aeromedical isolation team. This rapid response team, which has worldwide airlift capability designed to evacuate and manage patients under high-level containment, also offers a portable containment laboratory, limited environmental decontamination, and specialized consultative expertise. This article also examines technical aspects of the team's equipment, training, capabilities, and deployments. (+info)Bacterial toxin-antitoxin gene system as containment control in yeast cells. (2/121)
The potential of a bacterial toxin-antitoxin gene system for use in containment control in eukaryotes was explored. The Escherichia coli relE and relB genes were expressed in the yeast Saccharomyces cerevisiae. Expression of the relE gene was highly toxic to yeast cells. However, expression of the relB gene counteracted the effect of relE to some extent, suggesting that toxin-antitoxin interaction also occurs in S. cerevisiae. Thus, bacterial toxin-antitoxin gene systems also have potential applications in the control of cell proliferation in eukaryotic cells, especially in those industrial fermentation processes in which the escape of genetically modified cells would be considered highly risky. (+info)Dual system to reinforce biological containment of recombinant bacteria designed for rhizoremediation. (3/121)
Active biological containment (ABC) systems have been designed to control at will the survival or death of a bacterial population. These systems are based on the use of a killing gene, e.g., a porin-inducing protein such as the one encoded by the Escherichia coli gef gene, and a regulatory circuit that controls expression of the killing gene in response to the presence or absence of environmental signals. An ABC system for recombinant microorganisms that degrade a model pollutant was designed on the basis of the Pseudomonas putida TOL plasmid meta-cleavage regulatory circuit. The system consists of a fusion of the Pm promoter to lacI, whose expression is controlled by XylS with 3-methylbenzoate, and a fusion of a synthetic P(lac) promoter to gef. In the presence of the model pollutant, bacterial cells survived and degraded the target compound, whereas in the absence of the aromatic carboxylic acid cell death was induced. The system had two main drawbacks: (i) the slow death of the bacterial cells in soil versus the fast killing rate in liquid cultures in laboratory assays, and (ii) the appearance of mutants, at a rate of about 10(-8) per cell and generation, that did not die after the pollutant had been exhausted. We reinforced the ABC system by including it in a Deltaasd P. putida background. A P. putida Deltaasd mutant is viable only in complex medium supplemented with diaminopimelic acid, methionine, lysine, and threonine. We constructed a P. putida Deltaasd strain, called MCR7, with a Pm::asd fusion in the host chromosome. This strain was viable in the presence of 3-methylbenzoate because synthesis of the essential metabolites was achieved through XylS-dependent induction. In the P. putida MCR7 strain, an ABC system (Pm::lacI, xylS, P(lac)::gef) was incorporated into the host chromosome to yield strain MCR8. The number of MCR8 mutants that escaped killing was below our detection limit (<10(-9) mutants per cell and generation). The MCR8 strain survived and colonized rhizosphere soil with 3-methylbenzoate at a level similar to that of the wild-type strain. However, it disappeared in less than 20 to 25 days in soils without the pollutant, whereas an asd(+), biologically contained counterpart such as P. putida CMC4 was still detectable in soils after 100 days. (+info)Sequence analysis of cloned cDNA encoding part of an immunoglobulin heavy chain. (4/121)
The recombinant plasmid pH21-1 consists of mouse-derived complementary DNA (cDNA) in the E. coli plasmid pMB9. The mouse insertion has been completely sequenced, and encodes the CH3 domain and half the CH2 domain of the immunoglobulin gamma1 heavy chain. The predicted amino acid sequence differs at several positions from that previously published for this protein. The pattern of codon usage resembles that in some other eukaryotic messenger RNAs. A computer program has been used to predict the optimum secondary structure for the mRNA encoding the CH3 domain and the inter-domain junction. (+info)Countering the posteradication threat of smallpox and polio. (5/121)
After eradication, there is a small but finite risk that smallpox and/or poliomyelitis viruses could accidentally escape from a laboratory or be released intentionally. The reintroduction of either virus into a highly susceptible population could develop into a serious catastrophe. To counter such an occurrence will require the use of vaccine, perhaps in substantial quantities. In the United States, new stocks of smallpox vaccine are being procured and arrangements are being made for a standby production facility. Similar provisions need to be considered for polio. To counter an epidemic of polio will require the use of the oral vaccine, which is presently the World Health Organization-recommended vaccine of choice for countries throughout the developing world. In these countries, its continued use is advised because of its ability to induce intestinal immunity, its ability to spread to other susceptible household members and to protect them, its ease of administration, and its low cost. (+info)National laboratory inventory as part of global poliovirus containment--United States, June 2002. (6/121)
Since the initiation of the global poliomyelitis initiative in 1988 through 2001, the number of countries where polio is endemic decreased from 125 to 10, and the number of reported polio cases decreased >99%, from an estimated 350,000 to <1,000. The Global Commission for the Certification of the Eradication of Poliomyelitis, convened by the World Health Organization, will declare the world polio-free when all regions have documented the absence of wild poliovirus transmission for at least 3 consecutive years and when laboratories with wild poliovirus materials have implemented appropriate containment conditions. (+info)Infection of mice with aerosolized Mycobacterium tuberculosis: use of a nose-only apparatus for delivery of low doses of inocula and design of an ultrasafe facility. (7/121)
Aerosolized delivery of virulent or hypervirulent Mycobacterium tuberculosis requires careful consideration of methodology and safety. To maximize safety, we installed a nose-only aerosol apparatus that can reproducibly deliver a low dose (<100 CFU per mouse) of M. tuberculosis in a carefully designed biohazard facility. (+info)Measuring containment of viable infectious cell sorting in high-velocity cell sorters. (8/121)
BACKGROUND: With the advent of high-speed sorters, aerosols are a considerable safety concern when sorting viable infectious materials. We describe a four-part safety procedure for validating the containment. METHODS: This procedure includes aerosol containment, physical barriers, environmental controls, and personal protection. The Aerosol Management System (AMS) produces a negative pressure within the sort chamber, where aerosols are forced through a HEPA filter. Physical barriers include the manufacturer's standard plastic shield and panels. The flow cytometer was contained within a BSL-3 laboratory for maximum environmental control, and the operator was protected by a respiratory system. Containment was measured by using highly fluorescent Glo-Germ particles under the same conditions as the cell sort. RESULTS: Escaping aerosols were vacuumed for 10 min onto a glass slide and examined. With the AMS active and the cytometer producing the maximum aerosols possible, Glo-Germ particles remained within the sort chamber. Measurements taken directly outside the door averaged fewer than one particle per slide, and those taken at 2 ft away and on top of the sorter were completely negative. CONCLUSIONS: With this monitoring system in place, aerosols can be efficiently measured, thus reducing the risk to the operator while sorting viable infectious cells. (+info)A laboratory infection is an infection that occurs in a healthcare worker or laboratory personnel while working in a laboratory setting, typically with infectious agents such as bacteria, viruses, or fungi. These infections can be acquired through exposure to infected samples, equipment, or surfaces in the laboratory.
The risk of laboratory infection is higher in settings where high-risk agents are handled, such as in the study of highly infectious diseases like Ebola or SARS. The transmission of infectious agents in laboratories can occur through various routes, including:
1. Direct contact with infected samples or materials.
2. Contact with contaminated surfaces or equipment.
3. Inhalation of aerosols generated during procedures such as centrifugation or pipetting.
4. Exposure to infected personnel or animals in the laboratory.
To prevent laboratory infections, healthcare workers and laboratory personnel must follow strict safety protocols, including wearing personal protective equipment (PPE) such as gloves, gowns, and masks, and adhering to proper sterilization and decontamination techniques. Laboratories should also have ventilation systems that filter out infectious agents and should be designed with containment levels to minimize the risk of exposure.
Laboratory infections can have serious consequences for both the individuals involved and the broader community, including the potential for transmitting infectious diseases to others outside of the laboratory setting. Therefore, it is essential to have strict safety protocols and proper training for laboratory personnel to minimize the risk of laboratory-acquired infections.
Smallpox symptoms include fever, headache, and fatigue, followed by a characteristic rash that spreads from the face to other parts of the body. The disease is highly infectious and can be fatal, especially among young children and immunocompromised individuals. There is no specific treatment for smallpox, and vaccination is the most effective method of prevention.
The last naturally occurring case of smallpox was reported in 1977, and since then, there have been only a few laboratory-confirmed cases, all related to research on the virus. The WHO declared that smallpox had been eradicated in 1980, making it the first and only human disease to be completely eliminated from the planet.
While the risk of smallpox is currently low, there is concern that the virus could be used as a bioterrorism agent, and efforts are being made to maintain surveillance and preparedness for any potential outbreaks.
The disease is transmitted through the ingestion of contaminated water or food that contains the infective larvae of the worm. The symptoms of dracunculiasis usually develop within one to two months after infection and can include fever, headache, weakness, joint pain, and a skin rash.
The most distinctive feature of dracunculiasis is the presence of a painful skin lesion at the site of infection, which eventually develops into a blister-like swelling that contains the mature worm. The worm can grow up to 60 cm in length and can live for several months within the human host.
Dracunculiasis is diagnosed through the observation of the characteristic skin lesion and the presence of the worm in the blister. Treatment typically involves the surgical removal of the worm, which can be done using a fine-tipped needle or by applying heat to the blister to stimulate the worm's exit.
Prevention of dracunculiasis primarily involves improving access to safe drinking water and promoting good hygiene practices, such as washing hands before eating and avoiding consumption of uncooked or undercooked fish and other animals that may be infected with the parasite.
While dracunculiasis is generally not fatal, it can cause significant morbidity and disability, particularly in areas where the disease is common and treatment is limited. Therefore, efforts to control and eliminate this disease are important for improving public health outcomes in affected regions.
There are three main forms of poliomyelitis:
1. Non-paralytic polio, which causes symptoms such as fever, headache, and sore throat, but does not lead to paralysis.
2. Paralytic polio, which can cause partial or complete paralysis of the muscles in the limbs, trunk, and respiratory system. This form is more severe and can be fatal.
3. Post-polio syndrome, which occurs in some individuals years after they have recovered from a paralytic polio infection. It is characterized by new muscle weakness, pain, and fatigue.
Poliomyelitis was once a major public health problem worldwide, but widespread immunization campaigns have led to a significant decline in the number of cases. The World Health Organization (WHO) has set a goal of eradicating polio by 2018.
Treatment for poliomyelitis typically focuses on managing symptoms and supporting respiratory function. In severe cases, hospitalization may be necessary to provide intensive care, such as mechanical ventilation. Physical therapy and rehabilitation are also important in helping individuals recover from paralysis.
Prevention is key to controlling the spread of poliomyelitis. This includes vaccination with the oral poliovirus vaccine (OPV), which has been shown to be safe and effective in preventing polio. In addition, good hygiene practices, such as washing hands regularly, can help reduce the risk of transmission.
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Professional biohazard2
- We have friendly and professional biohazard containment representatives available to assist you around the clock at (866) 906-8786 ! (securerestoration.com)
- Blood alone can carry hundreds of different, life-threatening diseases, such as HIV, and Hepatitis B & C. Thus, it's important to contact a professional biohazard cleanup company to remediate the property and protect you, your family, and/or your employees. (frsga.com)
Infectious5
- Trash can with plastic liner complies with OSHA for the safe containment of infectious waste. (recycleaway.com)
- Complies with OSHA standards on blood borne pathogens for the safe containment of infectious waste. (recycleaway.com)
- Materials that are hazardous to humans as a result of their biological or infectious properties (as opposed to chemical or physical) are called biohazardous materials or simply biohazards. (csusb.edu)
- C. immitis, one of the most virulent and infectious fungal pathogens, poses a serious occupational hazard for laboratory personnel, especially in areas where the disease is not endemic and workers are less likely to practice biohazard safety level (BSL)-3 containment, which is required for the handling of this pathogen. (cdc.gov)
- The serious biohazard potential of C. immitis has led to its inclusion among the biological agents covered under the recently enacted Anti-Terrorist and Effective Death Penalty Act, which regulates interstate transport of infectious materials (11) . (cdc.gov)
Biological2
- The bio-shield is a barrier whose purpose is to create a complete hermetic seal between the differently qualified zones, providing maximum biological containment between the zones. (tuttnauer.com)
- The management of biological hazards through the proper application of engineered containment devices and administrative controls is usually referred to as biosafety or biohazard control. (csusb.edu)
Biosafety Level4
- This program consists of the continued development and implementation of a certified, academic training course for instruction in Good Laboratory Practices (GLP) in a Biosafety Level (BSL) 4 High Containment Environment. (nih.gov)
- therefore, it does not require any special containment practices beyond the normal requirements of the designated biosafety level. (ucsd.edu)
- The NIH Guidelines also document criteria for establishing different levels of containment for biohazards: Biosafety Level 1 through 4. (triumvirate.com)
- Here, we performed an independent evaluation of a commercially available surrogate virus neutralization test (sVNT, GenScript cPass™) that can be done without biosafety level 3 containment in less than 2 h. (itg.be)
Practices2
- Read content about powder containment hoods and how the removal of fume, toxins, and particulate can be an integral part of the integrity of your powder containment practices. (sentryair.com)
- We use the industry's best practices and equipment to clean up all biohazards contaminate and restore your property back to its original state prior to the damages. (frsga.com)
Cleanup6
- We are a local team of biohazard cleanup professionals in Arcadia, South Carolina, 29301 that has decades of combined experience in mitigating losses and helping our clients to protect and restore their properties. (securerestoration.com)
- First Response Services is your trusted, professional, IICRC certified, and insured biohazard cleanup company. (frsga.com)
- Biohazards contamination cleanup often requires blood and tissue cleanup especially when cleaning up a crime scene, suicide or another traumatic event. (frsga.com)
- After receiving your emergency biohazard cleanup call, we will arrive on-site and conduct an assessment of the damages. (frsga.com)
- First Response Services of Georgia is your trusted, local biohazard cleanup company. (frsga.com)
- For emergency biohazard contamination cleanup, call today! (frsga.com)
Representatives1
- If you are in the region, you can call us at (518) 888-3017 as soon as possible so our biohazard containment representatives can speak to you about all of our Biohazard Containment wonderful services. (rockenv.com)
Laboratory1
- With air constantly being drawn into a laboratory, it is extremely difficult for a microscopic particle (including biohazards ) to escape the room. (phe.gov)
Guidelines2
- Is Compliance with NIH Guidelines Required for Biohazard and rDNA Permitting? (triumvirate.com)
- Triumvirate Environmental biosafety consultants understand the importance of complying with NIH Guidelines and have extensive experience with biohazard and rDNA permitting. (triumvirate.com)
Company2
- Secure Restoration is Arcadia's leading biohazard cleaning company. (securerestoration.com)
- When you are in dire need of Biohazard Containment services on your Arcadia property, you know that you have a great company like Secure Restoration in your corner. (securerestoration.com)
Primary3
- These procedures should only be performed within a primary containment device. (phe.gov)
- This practice of maintaining negative air flow adds another layer of biocontainment (in addition to work done within primary containment devices). (phe.gov)
- Primary responsibility for proper Biohazard Management resides with all employees that may encounter biohazards including Custodians, Nurses, Public Safety Officers, Principal Investigators (PI), Lab Supervisors, and Instructional Support Technicians (IST), although important functions are also assigned to the Environmental Health and Safety Department (EH&S). (csusb.edu)
Services7
- If you are struggling and require Biohazard Containment services on your property, we know it can be a stressful time. (securerestoration.com)
- If you need details or want to get a biohazard containment tech out to your property to assess the Biohazard Containment services you may need, just pick up the phone and call us. (securerestoration.com)
- We pride ourselves in providing elite Biohazard Containment services when it's hard to find anyone else to do a good job at an affordable price point. (securerestoration.com)
- We know how important it is for you to get your home or business back to its original glory, so our Biohazard Containment services are very important to us to make sure you leave a happy customer. (securerestoration.com)
- Whether it's because of our premier customer service or our knowledgeable professionals, our Biohazard Containment services are unrivaled by anyone else in the area or in the industry. (securerestoration.com)
- At Rock Environmental, we use the finest tools and equipment to complete your Biohazard Containment services including the state-of-the-art SteraMist. (rockenv.com)
- If you need Biohazard Containment services on your house, call us at Rock Environmental now. (rockenv.com)
Safety1
- As pathogens, particulate, viruses, and biohazards have become more common to be found in the mail, it is imperative now more than ever to ensure some safety measures and controls are in place to prevent these hazards. (sentryair.com)
Require1
- If you require specialized posters, consultation, or biohazard supplies please submit an EH&S Service Request and an EH&S specialist will be happy to assist you. (csusb.edu)
Call3
- If you're worried about the presence of disease, tragedy, sickness or infection on your Arcadia, South Carolina, 29301 home or business property and believe it needs to be sanitized, call the biohazard containment professionals at Secure Restoration today. (securerestoration.com)
- Just pick up the phone and call the biohazard cleaning professionals who know best at Secure Restoration. (securerestoration.com)
- Send a call now to our biohazard decontamination professionals so that they can get down to business on your property in appropriate time. (rockenv.com)
Experience1
- With years of experience in the market, Tuttnauer produces reliable and safe bio- containment systems. (tuttnauer.com)
Standards1
- Tuttnauer is at the front lines, continuously creating new standards in the field of bio containment. (tuttnauer.com)
Risk1
- Our professional technicians will suit-up in protective clothing and masks, then will set-up professional containment to eliminate the risk of contamination. (frsga.com)
Service1
- Please submit an EH&S Service Request for specific information/assistance concerning the Biohazard Management Plan. (csusb.edu)
Important2
- In today's society the need for safe bio-containment systems is increasingly important. (tuttnauer.com)
- As gene drive research increases on campus, it's important to identify the appropriate containment needs for this research in animals and plants. (ucsd.edu)
Remove1
- High Efficiency Particulate Air (HEPA) filters are used to efficiently remove microscopic particles, including biohazards, from the air stream. (phe.gov)
Close1
- From our first visit, until the project is completed, we will remain in close communication with you regarding the Biohazard Containment job and its progress. (securerestoration.com)
Biosafety1
- This program consists of the continued development and implementation of a certified, academic training course for instruction in Good Laboratory Practices (GLP) in a Biosafety Level (BSL) 4 High Containment Environment. (nih.gov)
Evaluation1
- Researchers from the National Institute for Occupational Safety and Health (NIOSH) conducted a preliminary evaluation of the local exhaust ventilation at the delivery bins and a qualitative evaluation of the contaminant capture capabilities of the Biohazard Detection System (BDS) and Ventilation/Filtration System (VFS) for the Advanced Facer Canceller System (APCS). (cdc.gov)
Environment1
- Or, for example, if scientists gathering bat samples in remote caves get a bit too comfortable in a dangerous environment - because they've been there dozens of times before with no problem and the biohazard suits and masks are suffocating. (medscape.com)