A family of immunoglobulin-related cell adhesion molecules that are involved in NERVOUS SYSTEM patterning.
A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.
A contactin subtype that is predominantly expressed in the CEREBELLUM; HIPPOCAMPUS; NEOCORTEX; and HYPOTHALAMUS.
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
A contactin subtype that plays a role in axon outgrowth, axon fasciculation, and neuronal migration.
The inability to generate oral-verbal expression, despite normal comprehension of speech. This may be associated with BRAIN DISEASES or MENTAL DISORDERS. Organic mutism may be associated with damage to the FRONTAL LOBE; BRAIN STEM; THALAMUS; and CEREBELLUM. Selective mutism is a psychological condition that usually affects children characterized by continuous refusal to speak in social situations by a child who is able and willing to speak to selected persons. Kussmal aphasia refers to mutism in psychosis. (From Fortschr Neurol Psychiatr 1994; 62(9):337-44)
Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. These distortions are manifested in sustained social impairment, speech abnormalities, and peculiar motor movements.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Immunoglobulins produced in response to VIRAL ANTIGENS.
Antibodies produced by a single clone of cells.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
The profession of writing. Also the identity of the writer as the creator of a literary production.
Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.
A slowly progressive autoimmune demyelinating disease of peripheral nerves and nerve roots. Clinical manifestations include weakness and sensory loss in the extremities and enlargement of peripheral nerves. The course may be relapsing-remitting or demonstrate a step-wise progression. Protein is usually elevated in the spinal fluid and cranial nerves are typically spared. GUILLAIN-BARRE SYNDROME features a relatively rapid progression of disease which distinguishes it from this condition. (Adams et al., Principles of Neurology, 6th ed, p1337)
Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (GUILLAIN-BARRE SYNDROME) and POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots.
An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)
Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.
Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.
A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.
Any of numerous agile, hollow-horned RUMINANTS of the genus Capra, in the family Bovidae, closely related to the SHEEP.
An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.
A subtype of non-receptor protein tyrosine phosphatases that includes two distinctive targeting motifs; an N-terminal motif specific for the INSULIN RECEPTOR, and a C-terminal motif specific for the SH3 domain containing proteins. This subtype includes a hydrophobic domain which localizes it to the ENDOPLASMIC RETICULUM.
A subcategory of protein tyrosine phosphatases that are bound to the cell membrane. They contain cytoplasmic tyrosine phosphatase domains and extracellular protein domains that may play a role in cell-cell interactions by interacting with EXTRACELLULAR MATRIX components. They are considered receptor-like proteins in that they appear to lack specific ligands.

Analysis of receptor binding by the channel-forming toxin aerolysin using surface plasmon resonance. (1/114)

Aerolysin is a channel-forming bacterial toxin that binds to glycosylphosphatidylinositol (GPI) anchors on host cell-surface structures. The nature of the receptors and the location of the receptor-binding sites on the toxin molecule were investigated using surface plasmon resonance. Aerolysin bound to the GPI-anchored proteins Thy-1, variant surface glycoprotein, and contactin with similar rate constants and affinities. Enzymatic removal of N-linked sugars from Thy-1 did not affect toxin binding, indicating that these sugars are not involved in the high affinity interaction with aerolysin. Aerolysin is a bilobal protein, and both lobes were shown to be required for optimal binding. The large lobe by itself bound Thy-1 with an affinity that was at least 10-fold weaker than that of the whole toxin, whereas the small lobe bound the GPI-anchored protein at least 1000-fold more weakly than the intact toxin. Mutation analyses provided further evidence that both lobes were involved in GPI anchor binding, with certain single amino acid substitutions in either domain leading to reductions in affinity of as much as 100-fold. A variant with single amino acid substitutions in both lobes of the protein was completely unable to bind the receptor. The membrane protein glycophorin, which is heavily glycosylated but not GPI-anchored, bound weakly to immobilized proaerolysin, suggesting that interactions with cell-surface carbohydrate structures other than GPI anchors may partially mediate toxin binding to host cells.  (+info)

Functional interactions of the immunoglobulin superfamily member F11 are differentially regulated by the extracellular matrix proteins tenascin-R and tenascin-C. (2/114)

The axon-associated protein F11 is a GPI-anchored member of the immunoglobulin superfamily that promotes axon outgrowth and that shows a complex binding pattern toward multiple cell surface and extracellular matrix proteins including tenascin-R and tenascin-C. In this study, we demonstrate that tenascin-R and tenascin-C differentially modulate cell adhesion and neurite outgrowth of tectal cells on F11. While soluble tenascin-R increases the number of attached cells and the percentage of cells with neurites on immobilized F11, tenascin-C stimulates cell attachment to a similar extent but decreases neurite outgrowth. The cellular receptor interacting with F11 has been previously identified as NrCAM; however, in the presence of tenascin-R or tenascin-C cell attachment and neurite extension are independent of NrCAM. Antibody perturbation experiments indicate that beta(1) integrins instead of NrCAM function as receptor for neurite outgrowth of tectal cells on an F11.TN-R complex. Cellular binding assays support the possibility that the interaction of F11 to NrCAM is blocked in the presence of tenascin-R and tenascin-C. Furthermore, a sandwich binding assay demonstrates that tenascin-R and tenascin-C are able to form larger molecular complexes and to link F11 polypeptides by forming a molecular bridge. These results suggest that the molecular interactions of F11 might be regulated by the presence of tenascin-R and tenascin-C.  (+info)

NrCAM, cerebellar granule cell receptor for the neuronal adhesion molecule F3, displays an actin-dependent mobility in growth cones. (3/114)

The neuronal adhesion glycoprotein F3 is a multifunctional molecule of the immunoglobulin superfamily that displays heterophilic binding activities. In the present study, NrCAM was identified as the functional receptor mediating the inhibitory effect of F3 on axonal elongation from cerebellar granule cells. F3Fc-conjugated microspheres binding to neuronal growth cones resulted from heterophilic interaction with NrCAM but not with L1. Time-lapse video-microscopy indicated that F3Fc beads bind at the leading edge and move retrogradely to reach the base of the growth cone within a lapse of 30-60 seconds. Such velocity (5.7 microm/minute) is consistent with a coupling between F3 receptors and the retrograde flow of actin filaments. When actin filaments were disrupted by cytochalasin B, the F3Fc beads remained immobile at the leading edge. The retrograde mobility appeared to be dependent on NrCAM clustering since it was induced upon binding with cross-linked but not dimeric F3Fc chimera. These data indicate that F3 may control growth cone motility by modulating the linkage of its receptor, NrCAM, to the cytoskeleton. They provide further insights into the mechanisms by which GPI-anchored adhesion molecules may exert an inhibitory effect on axonal elongation.  (+info)

Pathological missense mutations of neural cell adhesion molecule L1 affect homophilic and heterophilic binding activities. (4/114)

Mutations in the gene for neural cell adhesion molecule L1 (L1CAM) result in a debilitating X-linked congenital disorder of brain development. At the neuronal cell surface L1 may interact with a variety of different molecules including itself and two other CAMs of the immunoglobulin superfamily, axonin-1 and F11. However, whether all of these interactions are relevant to normal or abnormal development has not been determined. Over one-third of patient mutations are single amino acid changes distributed across 10 extracellular L1 domains. We have studied the effects of 12 missense mutations on binding to L1, axonin-1 and F11 and shown for the first time that whereas many mutations affect all three interactions, others affect homophilic or heterophilic binding alone. Patient pathology is therefore due to different types of L1 malfunction. The nature and functional consequence of mutation is also reflected in the severity of the resultant phenotype with structural mutations likely to affect more than one binding activity and result in early mortality. Moreover, the data indicate that several extracellular domains of L1 are required for homophilic and heterophilic interactions.  (+info)

Compartmentation of Fyn kinase with glycosylphosphatidylinositol-anchored molecules in oligodendrocytes facilitates kinase activation during myelination. (5/114)

In many cell types, glycosylphosphatidylinositol (GPI)-anchored proteins are sequestered in detergent-resistant membrane rafts. These are plasma membrane microdomains enriched in glycosphingolipids and cholesterol and are suggested to be platforms for cell signaling. Concomitant with the synthesis of myelin glycosphingolipids, maturing oligodendrocytes progressively associate GPI-anchored proteins, including the adhesion molecules NCAM 120 and F3, in rafts. Here we show that these microdomains include Fyn and Lyn kinases. Both kinases are maximally active in myelin prepared from young animals, correlating with early stages of myelination. In the rafts, Fyn kinase is tightly associated with NCAM 120 and F3. In contrast, in oligodendrocyte progenitor cells lacking rafts or in raft-free membrane domains of more mature cells, F3 does not associate with Fyn. The addition of anti-F3 antibodies to oligodendrocytes results in stimulation of Fyn kinase specifically in rafts. Compartmentation of oligodendrocyte GPI-anchored proteins in rafts is thus a prerequisite for association with Fyn, permitting kinase activation. Interaction of oligodendrocyte F3 with axonal ligands such as L1 and ensuing kinase activation may play a crucial role in initiating myelination.  (+info)

Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein. (6/114)

Lipid rafts are regions of the plasma membrane that are enriched in cholesterol, glycosphingolipids and acylated proteins, and which have been proposed as sites for the proteolytic processing of the Alzheimer's amyloid precursor protein (APP). Lipid rafts can be isolated on the basis of their insolubility in Triton X-100 at 4 degrees C, with the resulting low-density, detergent-insoluble glycolipid-enriched fraction (DIG) being isolated by flotation through a sucrose density gradient. The detergent-insolubility of APP in mouse cerebral cortex relative to a variety of DIG marker proteins (alkaline phosphatase, flotillin, F3 protein and prion protein) and non-DIG proteins (alkaline phosphodiesterase I, aminopeptidase A and clathrin) has been examined. Alkaline phosphatase, flotillin, F3 protein and the prion protein were present exclusively in the DIG region of the sucrose gradient over a range of protein/detergent ratios used to solubilize the membranes and displayed a characteristic enrichment in the low-density fraction as the protein/detergent ratio was decreased. In contrast, most of the APP, alkaline phosphodiesterase I, aminopeptidase A and clathrin was effectively solubilized at all of the protein/detergent ratios examined. However, a minor proportion of these latter proteins was detected in DIGs at levels which remained constant irrespective of the protein/detergent ratio. When DIGs were isolated from the sucrose gradients and treated with excess Triton X-100, both the DIG marker proteins and APP, alkaline phosphodiesterase I and clathrin were predominantly resistant to detergent extraction at 37 degrees C. These results show that, although a minor proportion of APP is present in DIGs, where it is detergent-insoluble even at 37 degrees C, it behaves as an atypical lipid raft protein and raises questions as to whether lipid rafts are a site for its proteolytic processing.  (+info)

Protein tyrosine phosphatase alpha (PTPalpha) and contactin form a novel neuronal receptor complex linked to the intracellular tyrosine kinase fyn. (7/114)

Glycosyl phosphatidylinositol (GPI)-linked receptors and receptor protein tyrosine phosphatases (RPTPs), both play key roles in nervous system development, although the molecular mechanisms are largely unknown. Despite lacking a transmembrane domain, GPI receptors can recruit intracellular src family tyrosine kinases to receptor complexes. Few ligands for the extracellular regions of RPTPs are known, relegating most to the status of orphan receptors. We demonstrate that PTPalpha, an RPTP that dephosphorylates and activates src family kinases, forms a novel membrane-spanning complex with the neuronal GPI-anchored receptor contactin. PTPalpha and contactin associate in a lateral (cis) complex mediated through the extracellular region of PTPalpha. This complex is stable to isolation from brain lysates or transfected cells through immunoprecipitation and to antibody-induced coclustering of PTPalpha and contactin within cells. This is the first demonstration of a receptor PTP in a cis configuration with another cell surface receptor, suggesting an additional mode for regulation of a PTP. The transmembrane and catalytic nature of PTPalpha indicate that it likely forms the transducing element of the complex, and we postulate that the role of contactin is to assemble a phosphorylation-competent system at the cell surface, conferring a dynamic signal transduction capability to the recognition element.  (+info)

Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression. (8/114)

Axon guidance and target recognition depend on neuronal cell surface receptors that recognize and elicit selective growth cone responses to guidance cues in the environment. Contactin, a cell adhesion/recognition molecule of the immunoglobulin gene superfamily, regulates axon growth and fasciculation in vitro, but its role in vivo is unknown. To assess its function in the developing nervous system, we have ablated contactin gene expression in mice. Contactin-/- mutants displayed a severe ataxic phenotype consistent with defects in the cerebellum and survived only until postnatal day 18. Analysis of the contactin-/- mutant cerebellum revealed defects in granule cell axon guidance and in dendritic projections from granule and Golgi cells. These results demonstrate that contactin controls axonal and dendritic interactions of cerebellar interneurons and contributes to cerebellar microorganization.  (+info)

The polarized domains of myelinated axons are specifically organized to maximize the efficiency of saltatory conduction. The paranodal region is directly adjacent to the node of Ranvier and contains specialized septate-like junctions that provide adhesion between axons and glial cells and that const …
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Gurung, S., Asante, E., Hummel, D., Williams, A., Feldman-Schultz, O., Halloran, M., Sittaramane, V. and Chandrasekhar, A., (2018) Distinct roles for the cell adhesion molecule Contactin2 in the development and function of neural circuits in zebrafish. Mechanisms of Development : 152: 1-12.. Kassim, Y. M., Al-Shakarji, N. M., Asante, E., Chandrasekhar, A. and Palaniappan, K., (2018) Dissecting branchiomotor neuron circuits in zebrafish - Toward high-throughput automated analysis of jaw movements. IEEE International Symposium on Biomedical Imaging (ISBI): 943-947.. Chandrasekhar, A., Guo, S., Masai, I., Nicolson, T. and Wu, C-F., (2017) Zebrafish: from genes and neurons to circuits, behavior and disease. Journal of Neurogenetics : 31: 59-60.. Allen, J., Bhattacharyya, K., Asante, E., Almadi, B., Davis, J., Schafer, K., Cox, J., Voigt, M., Viator, J. and Chandrasekhar, A., (2017) Role of branchiomotor neurons in controlling food intake of zebrafish larvae. Journal of Neurogenetics : 31: ...
In the present study, we give the first detailed work-up of patients with IgM autoantibodies against neurofascin-155. Whereas IgG autoantibodies to neurofascin-155 have been reported in several studies and are supposed to cause a distinct clinical phenotype,2 17 18 IgM neurofascin-155 autoantibodies have so far only been described in a few patients and some of them also tested positive for IgG anti-neurofascin.4 7 Autoantibodies were detectable by ELISA and were confirmed by preabsorption experiments and by Western blot in four patients, but not by binding assays with neurofascin-155 transfected HEK293 cells or murine teased fibres. Most likely, the latter methods were not sensitive enough to detect the low titres of autoantibodies as indicated by a higher sensitivity of ELISA when comparing with cell based binding assays using serum of a patients with high titres of anti-neurofascin-155 IgG.. C1q deposition was not detectable by CBA although IgM antibodies are supposed to bind complement. ...
Two experiments were carried out to address the question of whether PTPα and contactin associate in a cis or trans conformation. First, anticontactin precipitates were prepared from lysates of COS cells expressing either PTPα or contactin, or from cells coexpressing both PTPα and contactin ( Fig. 5 A, lanes 1-3), as well as from another sample made by mixing lysates from the cells expressing either contactin or PTPα ( Fig. 5 A, lane 4). Anticontactin immunoprecipitates prepared from coexpressing cells contained PTPα, but those from mixed cell lysates did not ( Fig. 5 A, bottom, lanes 7 and 8). The lack of detectable association of PTPα and contactin in the mixed lysates suggests that interaction cannot take place in a trans conformation. Still, this may require a particular presentation of these cell surface molecules in growing cells that cannot form in solubilized cell lysates. Therefore, contactin-expressing cells were trypsinized 24 h after transfection and replated in dishes ...
Principal Investigator:WATANABE Kazutada, Project Period (FY):1993 - 1994, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Neurochemistry/Neuropharmacology
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
The Total Therapy treatment regimens developed at the Myeloma Institute have demonstrated great improvement in treatment outcomes for multiple myeloma patients. However, some patients still relapse early during maintenance treatment meaning that better options are still needed. This study will evaluate a treatment regimen that alternates two different 3-drug regimens every eight weeks for patients that have previously completed autologous stem cell transplant. The two regimens are bortezomib, lenalidomide, and dexamethasone (VRD) which will be alternated with Elotuzumab, lenalidomide, and dexamethasone (Elo RD). Effectiveness will be measured by the depth of response (i.e., whether or not minimal residual disease (MRD) negative status is achieved). The rate of MRD negativity from this study will be compared to historical control data from the Total Therapy 4 trial which used continuous VRD maintenance therapy after stem cell transplant(s ...
|h1|The CLOCHE SS / 19 collection is based on shapes, volumes and textures, harmoniously blended with the color trends of the season. The convenience, refinement and gentle strokes that follow the body line reach their climax in these tracks.|/h1| |h1|ma
|h1|The CLOCHE SS / 19 collection is based on shapes, volumes and textures, harmoniously blended with the color trends of the season. The convenience, refinement and gentle strokes that follow the body line reach their climax in these tracks.|/h1| |h1|ma
In neurons, generation and propagation of action potentials requires the complete accumulation of sodium stations on the axonal initial portion (AIS) and in the nodes of Ranvier through ankyrin G scaffolding. portion (AIS), and in myelinated axons, their saltatory conduction takes place via the nodes of Ranvier (Stuart et al., 1997; Kole et al., 2008). These procedures require a specific distribution of voltage-gated sodium stations that accumulate at high density in both of these highly specific axonal subdomains, described with the segregation from the cytoskeletal adaptor complicated ankyrin G/IV spectrin (Zhou et al., 1998; for review find Salzer, 2003). This scaffolding complicated not merely concentrates voltage-gated sodium stations Nav1.2 and Nav1.6 (Boiko et al., 2003), but additionally potassium stations KCNQ2/KCNQ3 (Devaux et al., 2004; Skillet et al., 2006), cell adhesion substances neurofascin-186 (NF-186), and neuronal cell adhesion molecule (NrCAM; Davis et al., 1996; Basak et ...
De tweelingbroers Oxide Pang Chun en Danny Pang kennen hun klassiekers, maar de beginnende regisseurs - alleen Oxide maakte tot nu toe een film, Ta fa likit (Who is running? uit 1998) - zitten nog in het stadium waarin ze zich moeilijk van hun voorbeelden kunnen loswrikken. Dat levert niet alleen open deuren, maar ook iets teveel bombast op: hun poging het extreem felle kleurenpalet van voormalig John Woo-cameraman Peter Pau te kopiëren is iets te opzichtig en de zwaar aangezette synthesizerscore veroorzaakt geborrel in de maagstreek. Maar in het ensceneren van brute geweldsscènes of achtervolgingen door broeierige steegjes tonen de heren zich meesters in de dop, en ze weten die typisch Aziatische uitbarstingen van energie, die de kijker zo aangenaam naar het hoofd kunnen stijgen, goed over te brengen ...
LGI1/CASPR2-antibody encephalitis is an autoimmune encephalitis in which antibodies target LGI1 (leucine-rich glioma inactivated 1) or CASPR2 (contactin-associated protein 2). Initially, typically, family members notice seizures and/or that their relative becomes forgetful, confused, drowsy and withdrawn.
BACKGROUND: Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to lack of passage of mAbs across the blood-brain barrier the trigeminal system has been suggested a possible site of action because it lacks blood-brain barrier and hence is available to circulating molecules. The trigeminal ganglion (TG) harbors two types of neurons; half of which store CGRP and the rest that express CGRP receptor elements (CLR/RAMP1). METHODS: With specific immunohistochemistry methods, we demonstrated the localization of CGRP, CLR, RAMP1, and their locations related to expression of the paranodal marker contactin-associated protein 1 (CASPR). Furthermore, we studied functional CGRP release separately from the neuron soma and the part with only nerve fibers of the trigeminal ganglion, using an enzyme-linked immunosorbent assay. RESULTS: Antibodies towards CGRP and CLR/RAMP1 bind to two different ...
Browse Item # 75-001, CASPR/Neurexin IV in the Antibodies, Inc. catalog including Item #,Item Name,Description,Target,Applications,Clone,IgG Isotype,Species Reactivity,Validation,Type,Format,Cross Reactivity,Expected Banding Pattern,Host,Label,Antibo
Pillar III: Isang magkasamang pakikipagsosyo sa EU / US sa pagpapalakas sa pandaigdigang supply ng bakuna at mga therapeutics: ang EU at Estados Unidos ay makikinabang ang kanilang bagong inilunsad na Joint COVID-19 Manufacturing and Supply Chain Taskforce upang suportahan ang paggawa ng bakuna at therapeutic at pamamahagi at mapagtagumpayan ang mga hamon sa supply chain. Ang mga nagtutulungan na pagsisikap, na nakabalangkas sa ibaba, ay isasama ang pagsubaybay sa mga pandaigdigan na kadena ng suplay, pagtatasa ng pandaigdigang pangangailangan laban sa supply ng mga sangkap at mga materyales sa paggawa, at pagkilala at pagtugon sa mga bottleneck na real time at iba pang mga nakakagambalang kadahilanan para sa pandaigdigang paggawa ng bakuna at therapeutics, pati na rin ang pag-uugnay ng mga potensyal na solusyon at mga pagkukusa upang mapalakas ang pandaigdigang paggawa ng mga bakuna, mga kritikal na input, at mga pandagdag na suplay.. Pilar IV: Isang Pinagsamang Panukala ng EU / US upang ...
Drinking water from your ceramic water dispenser or any other source is a brilliant way to lose weight while dieting. Often, whilst we sense hungry, were genuinely dehydrated and want a drink of water. This is an smooth concept to check yourself, next time you sense hungry, have a pitcher of water and wait half of an hour. If you still experience hungry, you want to consume, but if the starvation has subsided, you then have been sincerely dehydrated. Drinking cold water makes you experience fuller, and this satiates the appetite. However, there are also foods which permit you to to conquer starvation pangs whilst dieting, here are four of them.. 1. Choose High in Fibre Foods:. Foods which can be high in fibre make us sense fuller for longer, and this will help to certainly suppress your urge for food. The greater commonplace selections would be potatoes, grains, and beans. However, a few humans are unaware that ingredients, such as nuts, apples, pears and leafy vegetable, are also very high in ...
Dr. Katherine Pang, PhD, JD, MBA, ThM, Psychologist, Dallas, TX, 75214, (469) 828-7609, I work with adolescents, individuals, couples, and families and use cognitive behavioral techniques and strategies to address a variety of mental health issues. My emphasis is on transformative change and equipping each one of my clients with the skills to overcome the complexities of lifes challenges and find ways to successfully navigate emotional and mental pain in the process of healing. I approach each client uniquely so as to develop a treatment plan and goals that are specific to your needs and concerns.
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7) X. Pang, M. J. Zhang, L. X. Zhou, F. Xie, H. Lu, W. He, S. B. Jiang, L. Yu and X. Y. Zhang. (2011) Discovery of a Potent Peptidic Cyclophilin A Inhibitor Trp-Gly-Pro. European Journal of Medicinal Chemistry. 46, 1701- ...
Pang, Mingxiong; Woodward, Andrew; Agarwal, Vikram; Guan, Xueying; Ha, Misook; Ramachandran, Vanitharani; Chen, Xuemei; Triplett, Barbara; Stelly, David; Z Jeffrey Chen (GenomeBiology.com, 2009) ...
Silveira, T. L., Veloso, E. S., Gonçalves, I. N. N., Costa, R. F., Rodrigues, M. A., Cassali, G. D., Delpuerto, H. L., Pang, L., Argyle, D. & Ferreira, E., 23 Apr 2020, (E-pub ahead of print) In: Veterinary and Comparative Oncology.. Research output: Contribution to journal › Article › peer-review ...
Having snoring problems? Try Nose, Palate and Tonque surgeries by an ENT expert, Dr Kenny Pang, Asia Sleep Centre in Singapore. Call (65) 6836 0060 for more info.
Ang California ay may mga ipinag-aatas at rekomendasyon para sa mga mega-event para mabawasan ang transmisyon ng COVID-19. Sa page na ito: Ano ang mga mega-event Mga indoor na event Mga outdoor na event Mga mask sa mga event Higit pang impormasyon Ano ang mga mega-event Ang mga mega-event ay mga indoor na event na may 1,000 o higit pang tao at ang mga outdoor na event ay may 10,000 o higit pang tao. Kasama rito ang mga event tulad ng: Mga convention, conference, at expo Mga Concert, […]
Pudney, Christopher R., Hay, Sam, Levy, Colin, Pang, Jiayun, Sutcliffe, Michael J., Leys, David and Scrutton, Nigel S. (2009) Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction. Journal of the American Chemical Society, 131 (47). pp. 17072-17073. ISSN 0002-7863 (Print), 1520-5126 (Online) (doi:10.1021/ja908469m) Hay, Sam, Pudney, Christopher R., McGrory, Tom A., Pang, Jiayun, Sutcliffe, Michael J. and Scrutton, Nigel S. (2009) Barrier compression enhances an enzymatic hydrogen-transfer reaction. Angewandte Chemie International Edition, 48 (8). pp. 1452-1454. ISSN 1433-7851 (Print), 1521-3773 (Online) (doi:10.1002/anie.200805502) Hay, Sam, Pang, Jiayun, Monaghan, Phillip J., Wang, Xi, Evans, Rhiannon M., Sutcliffe, Michael J., Allemann, Rudolf K. and Scrutton, Nigel S. (2008) Secondary kinetic isotope effects as probes of environmentally-coupled enzymatic hydrogen tunneling reactions. ChemPhysChem, 9 (11). pp. 1536-1539. ISSN ...
Chargers that you just cant afford to lose will soon become unnecessary. In the wireless world of Bluetooth, NFC, and Wi-Fi networking, all we might need will be a charging surface - without any cords, of course. You might think this has already been created by Tesla, but theres more.. There is a chance that remote charging may soon become a reality, and you will be able to charge your phone from anywhere without any physical contact at all.. Life may seem much more comfortable with all these things around us. But once gone, you might think that you never needed them at all. What do you think will be the result of such drastic changes? Share your thoughts with us in the comments below.. ...
中風微創手術, Endovascular therapy, 內血管治療, 腦內血管介入治療, 腦瘤, 腦血瘤, 大腦麻痺, 腦外科, 神經外科, 彭家雄, Pang Ka Hung, Peter Pang, 中風急救, 中風治療, Stroke, PCI, iv rtPA, 薄血藥, 腦血管支架, 腦血管狹窄, 預防中風, 中風風險評估, 黃金3小時, 黃金8小時
Vengeance is a Golden Blade [飛燕金刀] (1969) Starring Chin Ping, Yueh Hua, Tang Ching, Kao Pao Shu, Goo Man-Chung, Pang Pang, Lee Pang-Fei, Chiu Hung, Law Hon, Ngai Ping-Ngo, Wong Ching Ho, Hao Li-Jen, Tsang Choh-Lam Directed by Ho Meng-Hua Expectations: High. You cant go wrong with that title, right? The reason I made it…
Earlier this year, Tigray region had been urging the federal government to stick to the original schedule and carry out national elections for several months.
Buweno, sa ngalan ng aking kaharian at nang akin nasasakopan, gusto kong magpasalamat kay BINO. Maraming salamat parekoy, dahil binigyan mo ko ng isa pang dahilan para magpatuloy sa pagbablog, hehehe, itong mga nakaraan araw kasi parang natatamod na ako magblog, at dahil dito nagkaroon ako ng panibago at kakaibang enerhiya sa katawan upang ipagpatuloy ang mga pinaglalaban ko sa buhay, lalo na ang hangarin ng aking kaharian na gulohin ang matitino ninyong mga utak. MABUHAY ka BINO ...
Chronic pain is written for me; morning stiffness, evening pangs, uncooperative muscles. The storyline is scripted by doctors and researchers. How the story plays out, however, is my privilege as the lead actor to put my personal spin on the lines. I rise like the sun, slowly from the horizon yet bright and welcoming. Staging…
Inihayag ngayong Miyerkoles ng Department of Education na maaari pang humabol sa enrollment ang mga estudyante sa public schools hanggang Nobyembre.
Are you one of those moms like me, who panicked when the news about JE victims circulated online?. It was very alarming to hear this but the good news is wala tayong dapat ika-worry, dahil wala pang outbreak ng JE sa Pilipinas mga inays.. ...
Wang, Le; Wan, Zi Yi; Bai, Bin; Huang, Shu Qing; Chua, Elaine; Lee, May; Pang, Hong Yan; Wen, Yan Fei; Liu, Peng; Liu, Feng; Sun, Fei; Lin, Grace; Ye, Bao Qing; Yue, Gen Hua ...
Yang Zhao, Ming Zhang, Xinping Luo, Chongjian Wang, Linlin Li, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Chengyi Han, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu ...
Gamot para matagal labasan ang lalake - MGA PANALANGIN: GAYUMA ( pambabae at pang lalake). Ideal for treating acne spots directly.
Oncotarget | https://doi.org/10.18632/oncotarget.12922 Wei Shi, Yanxue Yin, Yao Wang, Bo Zhang, Pei Tan, Ting Jiang, Heng Mei, Jun Deng, Huafang Wang, Tao Guo, Zhiqing Pang, Yu Hu
C.M. Campbell, S. Chouhan, C. Guenaut , D. Lawton, F. Marti, J. Ottarson, S. Schwarz, P. Zavodszky, A.F. Zeller, G. Bollen, D.J. Morrissey, G. Pang ...
Weeks total came out to a little under 81 miles, with a rolling 8-day total (Sunday-Sunday) of 103+ miles. The most important thing is that Im feeling healthy. Theres an errant ache here or a pang there, but nothing too concerning, and all part of what happens when pushing ones body (and mind) into uncharted training territory. However, Ive shuffled things around and am making this week a cutback week, with somewhere around 65 miles on tap. That was close to my peak week last year, so Im pleased with the progress Ive made ...
Hi All, Does anyone believe that by stopping smoking will help reduce the pangs of the tinnitus... Has anyone out there quit and has helped there...
New research shows that fatherhood can make you a better man. While men dont endure the pangs of childbirth, studies show they get some of the same cognitive and physical benefits from their own altered biochemistry, which occurs once the baby arrives. ...
The Ig-like domains of L1 can consider component in homophilic and heterophilic interactions ... condition models and human patients of Advertisement.
Ig Superfamily Molecules in the Nervous System автора Peter Sonderegger можно найти, купить на сайте ReadRate.com. На нашем сервисе вы найдете отзывы о книге.
NRCAM (neuronal cell adhesion molecule), Authors: Justyna Janik, Barbara Czarnocka. Published in: Atlas Genet Cytogenet Oncol Haematol.
TABLE-US-00004 TABLE 4 Cell and biological adhesion Fold Symbol Gene name Gene assignment change CLDN7 claudin 7 Involved in the formation of 2.74 tight junctions between epithelial cells PCDHB5 Protocadherin Member of the 3.32 beta-5 protocadherin beta gene cluster CLDN3 Claudin 3 Member of the claudin 3.93 family, is an integral membrane protein and a component of tight junction strands. CNTN6 contactin 6 Contactins mediate cell 3.09 surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. PKHD1 polycystic kidney Localized predominantly at 3.38 and hepatic the disease 1 apical domain of polarized epithelial cells, suggesting it may be involved in the tubulogenesis and/or maintenance of duct-lumen architecture. PCDHB2 protocadherin The extracellular domains 2.94 beta 2 interact in a homophilic manner to specify differential cell-cell connections. CDH1 E-cadherin cell adhesion molecule 3.27 (epithelial) CX3CL1 hemokine ...
Dr. Pang is a professor of optometry and the Assistant Dean for Research at the Illinois College of Optometry. Dr. Pang is active in both didactic teaching, including lecture and lab, and clinical teaching. Dr. Pang is an attending optometrist in the Pediatric and Binocular Vision service at the Illinois Eye Institute. Her research interests are in the areas of amblyopia, strabismus, and binocular vision function. Currently, she is the principal investigator for several NIH funded studies and other research projects. She has authored more than 110 peer reviewed publications and abstracts. In addition, Dr. Pang is in the editorial boards of four prestigious journals and is an active scientific referee for thirteen major journals. Dr. Pang is a fellow of the American Academy of Optometry and a diplomate of American Board of Optometry. ...
Contactin 1, Polyclonal, Invitrogen™ 100μL; Unconjugated Contactin 1, Polyclonal, Invitrogen™ Primary Antibodies Ci to Cx
Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. Mutations of
F3C)F2SiONMe2 was prepared from LiONMe2 and F3CSiF3- It was characterized by gas IR and multinuclear solution NMR spectroscopy and by mass spectrometry. Its structure was elucidated by single crystal X-ray crystallography and by gas electron diffraction. (It exists as a conformer mixture.) Important findings were extremely acute SiON angles [solid 74.1 (1)degrees, gas anti 84.4(32)degrees and gauche 87.8(20)degrees] and short (SiN)-N-... distances [solid 1.904(2) angstrom]. The bending potential of the SiON unit was calculated at the MP2/6-311++G(3df,2dp) level of theory and appears very flat and highly asymmetric. The calculated atomic charges (NPA) are counterintuitive to the expected behavior for a classical Si-N dative bond, as upon formation of the (SiN)-N-... bond electron density is transferred mainly from oxygen to nitrogen, while the silicon charge is almost unaffected. Despite the molecular topology of a three-membered ring, the topology of the electron density shows neither a bond ...
Complete information for CNTN2 gene (Protein Coding), Contactin 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for CNTN2 gene (Protein Coding), Contactin 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
CNTN1 - CNTN1 (untagged)-ORIGENE UNIQUE VARIANT 1 of Human contactin 1 (CNTN1), available for purchase from OriGene - Your Gene Company.
The neurofibromatosis 2 (NF2) tumor suppressor protein merlin is commonly mutated in human benign brain tumors. The gene altered in NF2 was located on human chromosome 22q12 in 1993 and the encoded protein named merlin and schwannomin. Merlin has homology to ERM family proteins, ezrin, radixin, and moesin, within the protein 4.1 superfamily. In efforts to determine merlin function several groups have discovered 34 merlin interacting proteins, including ezrin, radixin, moesin, CD44, layilin, paxillin, actin, N-WASP, betaII-spectrin, microtubules, TRBP, eIF3c, PIKE, NHERF, MAP, RalGDS, RhoGDI, EG1/magicin, HEI10, HRS, syntenin, caspr/paranodin, DCC, NGB, CRM1/exportin, SCHIP1, MYPT-1-PP1delta, RIbeta, PKA, PAK (three types), calpain and Drosophila expanded ...
FIG. 3. Distribution of contactin protein in stage 37/8 embryos, visualized by whole-mount immunocytochemistry. (A) A lateral view of the anterior 2/3 of the stained embryo, showing nervous tissue-specific distribution of contactin immunoreactivity. (B) An enlarged dorsal view of the brain portion of the embryo shown in (A). Axon tracts in the brain and primary olfactory region (arrowhead) are contactin positive. (C, D, and G) Cross sections of the stained embryo at the levels of midbrain (C), hindbrain (D), and posterior spinal cord (G). Contactin is expressed in the postoptic commissure and the optic chiasm of the lateral diencephalon (arrowheads in C) and the fasciculus longitudinalis medialis in the ventral marginal region (arrowheads in D). (E and F) Enlarged lateral (E) and dorsal (F) views of a part of the embryos, showing contactin-positive dorsal and ventral spinal fascicles. An arrow and an arrowhead in (E) represent contactin-positive cell bodies of a RB neuron and an EM neuron, ...
Our patient underwent numerous investigations: serologic tests included inflammatory markers (erythrocyte sedimentation rate, C-reactive protein, and antinuclear antibody), aquaporin-4 (AQP4) antibodies, myelin oligodendrocyte glycoprotein (MOG) antibodies, and infectious testing including HIV, tuberculosis, and syphilis screening, bacterial cultures, and fungal cultures; all results were normal. CSF analysis revealed the following: total nucleated cells (TNC), 12 cells/μL; erythrocytes, 1,000 cells/μL; protein, 98 mg/dL; glucose, 69 mg/dL; 0 oligoclonal bands; negative cytology and flow cytometry; negative bacterial and fungal testing. A CT chest/abdomen/pelvis was unremarkable.. Both serum and CSF autoimmune encephalopathy panels were sent to Mayo Clinic, which includes antibodies directed against N-methyl-D-aspartate receptor (NMDAR), leucine-rich glioma-inactivated 1 (LGI-1), contactin-associated protein 2 (CASPR2), glutamic acid decarboxylase (GAD65), GABAB receptor, ...
Our knowledge of enzyme-catalysed reactions has traditionally been gained from crystallography and solution studies. However, due to rapid developments in computer power and software, computational tools are playing an increasingly important role in obtaining an atomistic understanding of how enzymes achieve enormous rate accelerations.. The computational approaches can reveal aspects of a reaction that are difficult to access through experiment. Thus, combining the strength of the two can provide very detailed insight into enzyme catalysis, the knowledge of which could lead to the development of new drugs (most function as inhibitors of enzymes) and the design of efficient catalysts with many industrial applications.. Dr Pangs research aims at elucidating, from the quantum phenomenon to the macromolecular levels, fundamental mechanisms of enzyme activity. The current focus is to explore how protein dynamics - ranging from local atomic vibrations on a femto to picosecond time scale to larger ...
Invitation to the seminar by Dr. Paul Pang, the Decentralized Machine Learning Intelligence (DMLI) Laboratory/ Department of Computing, Faculty of Creative Industries and Business, Unitec Institute of Technology, New Zealand in the topic Incremental Linear Discriminant Analysis over Compressed Data Streams on Monday 29th October 2012 at 10.30 น. - 12.00, the meeting room 3/3, 3rd floor, SIT.. Please call 02-470-9850 for more information. ...
L1, also known as L1CAM, is a transmembrane protein; it is a neuronal cell adhesion molecule, member of the L1 protein family, of 200-220 kDa, and…
Mouse monoclonal antibody raised aginst synthetic peptide of Cntn1. A synthetic peptide corresponding to amino acids of 21-37 at extracellular domain of rat Cntn1. (MAB11957) - Products - Abnova
Mouse monoclonal antibody raised against synthetic peptide of Cntn1. A synthetic peptide corresponding to amino acids 21-37 at extracellular domain of rat Cntn1. (MAB11960) - Products - Abnova
کانتکتین ۱ (انگلیسی: Contactin 1) یک پروتئین است که در انسان توسط ژن «CNTN۱» کُدگذاری می‌شود. پروتئینی که توسط این ژن ساخته می‌شود، در واقع، عضوی از اَبَرخانوادهٔ ایمنوگلوبولین‌هاست.[۲][۳] کانتکتین ۱، یک پروتئین غشاء عصبی متصل به گلیکوزیل‌فسفاتیدیل‌اینوزیتول است که در اتصال سلولی نقش دارد. احتمال دارد این پروتئین در تشکیل اتصالات آکسونی در جریان رشد و تکامل دستگاه عصبی نقش داشته باشد. دو گونه پیرایش آران‌ای مختلف برای این ژن یافت شده‌است که ایزوفرم‌های پروتئینی مختلفی را می‌سازند.[۳] ...
Neurofascin-155 (NF155) and caspr are transmembrane proteins found at discrete locations early during development of the nervous system. NF155 is present in the oligodendrocyte cell body and processes, whereas caspr is on the axonal surface. In mature nerves, these proteins are clustered at paranode …
Drinking water, and lots of it, is always healthy and thats more than welcome!. Natural and safe to consume, one cannot have too much water. Matter of fact, its highly advisable for one to drink water as much as half of their weight in pounds.. Heres a little-known fact - dehydration often disguises itself as hunger pangs. And these hunger pangs often drive us rushing to the dining table. HOWEVER, its been proven that a glass of water is more than enough to ward off those hunger pangs…and that means you wont be tempted to eat unnecessarily.. And lets NOT forget about the cleansing effects of water, especially for your colon! Your colon, by the way, is usually filled with harmful substances and waste buildup. Getting rid of them means a cleaner colon that leads to a healthier and better-performing body.. ...
Invitrogen Anti-Contactin 5 Polyclonal, Catalog # PA5-58814. Tested in Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC) and Immunohistochemistry (IHC) applications. This antibody reacts with Human samples. Supplied as 100 µL purified antibody (0.2 mg/mL).
View mouse Cntnap4 Chr8:112570043-112882717 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Egg, larval and osteological development of the northern searobin, Prionotus carolinus, is described, principally from laboratory reared specimens. Egg diameter ranges from 0.87 to 0.97 mm, and the eggs contain 11 to 37 oil globules, which migrate to various locations within the egg during development. Gastrulation occurs at 27 hr, embryo is halfway around the yolk at 52 hr, and hatching occurs between 120 and 155 hr at 15°C. Prominent pigmentation of the embryo consists of a dark cluster of chromatophores just posterior to the developing eye and the beginning of a transverse band halfway between the vent and notochord tip just prior to hatching. Newly-hatched larvae range from 2.8 to 3.1 mm. The transverse band of pigment is fully developed and is an important characteristic in identifying early P. carolinus larvae. The pectoral fins are present at hatching and remain a characteristic feature.. Adult meristics are complete by 7.0 mm. Larval head length increases during development becoming ...
3D Mga Modelo ng Highway Structures sa Flatpyramid.. Ang isang highway ay isang daan para sa mataas na bilis ng trapiko ng kotse na walang mga interseksyon sa isang antas na may iba pang mga kalsada, tren o tram track, o mga landas ng pedestrian o bisikleta.. Idinisenyo para sa mga high-speed na sasakyan, ang mga highway para sa bawat direksyon ng paglalakbay ay pinaghihiwalay ng isang hadlang o iba pang mga teknikal na paraan ng konstruksiyon at mayroong hindi bababa sa dalawang daan para sa pagmamaneho sa bawat direksyon, at kadalasan ng malawak na margin para sa pagpapahinto ng mga kotse sa mga hindi inaasahang sitwasyon.. Ang mga paglabas sa mga motorway ay nilagyan ng mga braking at acceleration lane. Ipinagbabawal na pumasok sa mga motorway para sa mga sasakyan na ang pinakamataas na pinapayagang bilis ay mas mababa sa isang tiyak na halaga (halimbawa, mga moped o traktora, depende sa tiyak na bilis sa estado), pati na rin sa bisikleta at transportasyon ng kabayo. Gayundin, ipinagbabawal ...
These are very thin variable potentiometers. By pressing down on various parts of the strip, the resistance linearly changes from 100Ohms to 10,000Ohms allowing the user to very accurately calculate the relative position on the strip. Can be used as an accurate positional indicator for CNC head positioning, variable us
A new anti-spam extension has been installed in this forum. If you have problem registering or login the forum, please do not hesitate to email the admin ...
A sz vel gtelens g s lyos llapot, ilyenkor a sz v nem k pes hat konyan v rt pump lni a szervezetbe - ennek okai s t netei sokf l k lehetnek. A miel bbi felismer s letment !
The death of actor Aloysius Pang (Pang) while serving his National Service duties caused me sadness and anger. Sadness over the loss of a young life full of unfulfilled potential and anger because of a seeming lack of accountability on the part of the government over these deaths. While inquiries are held when incidences such as these occur, they occur …. Read More » ...
Snacking is as important as any meal of the day. If you ever heard munching all day is not good. Read this to know how munching and snacking is healthful..
See NAS NIV). Isaiah 21:3 Therefore are my loins filled with anguish; pangs have taken hold upon me, as the pangs of a woman in travail: I am pained so that I cannot hear; I am dismayed so that I cannot see ...
Contactin-associated protein-like 2 protein, or Caspr2, is a neuronal transmembrane member of the Neurexin family. Structural features of Caspr2 include epidermal growth factor repeats, laminin G domains, F5/8 type C domain, fibrinogen-like domains, and PDZ binding sites. Caspr2 is a cell adhesion molecule as well as a receptor. It is involved in mediating cell-cell interactions in the nervous system and involved in neural-glia interactions and clustering of potassium channels in myelinated axons. It is expressed at the juxaperanodal region of nodes of Ranvier in the CNS and PNS. Changes in expression have been associated with increased susceptibility to autism and epilepsy ...
2017-09-13: [[Nan:2017-09-13-mvi-rec.sport.pro-wrestling.moderated,Moderator Vacancy Investigation (MVI) rec.sport.pro-wrestling.moderated ...
2011-03-27: [[Nan:2011-03-27-rfd-news.admin.net-abuse.blocklisting,2nd RFD: news.admin.net-abuse.blocklisting moderated (remove) LAST CALL FOR COMMENTS ...
CNTN6 Polyclonal Antibody (CAB14275)OverviewTitle:CNTN6 Polyclonal Antibody (CAB14275)Size:100µLCode:CAB14275Host Species:RabbitPurification:Affinity purificationIsotype:IgGBackgroundThe protein encoded by this gene is a member of the immunoglobulin ...
Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari. ...
Kan, Lijuan; Grozhik, Anya V.; Vedanayagam, Jeffrey; Patil, Deepak P.; Pang, Nan; Huang, Yi-Chun; Joseph, Brian; Lin, Ching-Jung; Despic, Vladimir; Guo, Jian; Yan, Dong; Kondo, Shu; Deng, Wu-Min; Jaffrey, Samie R.; Lai, Eric C.; Lim, Kok Seong; Dedon, Peter C (Nature Publishing Group, 2017-07) ...
Patunayan na ang mga piraso ay maliit Kung hindi pindutin ang para sa 15 higit pang mga segundo Ad Paraan 2 ng 3 Crush na may isang gulugod na slicer ng gulay Bumili ng isang spiral na gulay slicer Ito ay katulad ng isang mansanas na mansanas Kailangan mong ipakilala ang gulay at i-on ang pihitan sa pamamagitan ng talim na may isang paggalaw ng spiral Mayroong ibat ibang mga uri ng ...
Ano ang dapat gawin once na malaman mo na lahat? Walang dapat gawin, Hangat wala pang namamagitan sa inyo na special na emotion at relasyon ay wala kang dapat gawin. Steady ka lang ineng, steady maligaya ka lang ang dapat. Wala kang obligasyon/dapat na gawin dahil lang sa nalaman mo na tinatangi ka ng isang tao o may pagtingin sayo ang isang tao. Kumilos ka ayun sa kilos mo, tumawa ka ayun sa tawa mo, lumakad ka ayun sa lakad mo, at umutot ka ayun sa utot mo. Tuloy mo lang ang buhay mo, kung ano ka, at kung sino ka ...
Kapag tapos na ang wizard, i-charge ang relo gamit ang kasamang USB cable hanggang sa puno na ang charge ng baterya.. Kailangan mong i-download at i-install ang SuuntoLink sa iyong PC o Mac upang kumuha ng mga software update para sa iyong relo. Lubusan naming inirerekomenda ang pag-a-update ng iyong relo kapag available na ang bagong release ng software.. Bumisita sa www.movescount.com/connect para sa higit pang impormasyon. ...
Photo by: Benhur Arcayan/ Malacanang Photo Bureau). President Aquino, who arrived at Batasang Pambansa via the Presidential chopper passed 3:30 in the afternoon, opened his 2011 SONA recalling his anti-siren campaign when he assumed presidency last year. The President relates the policy as a symbol of change as wangwang signifies abuse of authority over the past years.. Humarap po ako sa inyo noong aking inagurasyon at sinabing: Walang wang-wang sa ating administrasyon. At ngayon, patuloy nating itinitigil ito. Naging hudyat at sagisag po ito ng pagbabago, hindi lamang sa kalsada, kundi pati na rin sa kaisipan sa lipunan. PNoy stated as he delivers his speech.. Sa matagal na panahon, naging simbolo ng pang-aabuso ang wang-wang….. Ang mga dapat naglilingkod ang siya pang nang-aapi. Ang panlalamang matapos mangakong maglingkod-iyan po ang utak wang-wang. Aquino added.. President Aquino continued his speech with the rundown of accomplishments of his administration for the past year citing ...
Ginagamit ang mga alerto na tunog at vibration para sa mga notification, alarma at iba pang mga mahalagang kaganapan at pagkilos. Parehong maaaring i-adjust sa mga setting sa ilalim ng General (Pangkalahatan) » Tones (Mga Tunog).. Para sa bawat isa, maaari kang pumili sa mga sumusunod na opsyon:. ...
Shuo Pang,1,*,† Chao Han,1,† Mihoko Kato,2 Paul W. Sternberg,2 and Changhuei Yang1 1Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA 2Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, California 91125, USA †These authors contributed equally to this work. *Corresponding author: [email protected] ...
Ive been doing some thinking(theres a surprise), and I realized just a short while ago that nothing ever works out for me...whenever I get close with anyone, or really start to open up to someone to the point where I start feeling those little pangs in the back of your spleen that threaten to become something that may grow into love(gasp...not the l word) someday, whenever I get to that point, extenuating circumstances present themselves like clockwork, and put simply...fuck everything up. So I thought about it for quite some time, and I was *this* close to just deciding to get one up on circumstances and just not get close to anyone ever again...I thought I was a strong person, I thought I could stand up to all the shit that I incur just because I get so close with people so quickly, but Ive run out of energy...and mistake me not when I say that it requires a VERY LARGE portion of energy to put up with the scarring emotional shit you go through when you open up to someone and something gets ...
Clifford LK Pang (2014) The Orientation, Application and Efficacy Evaluation of Hyperthermia in Integrative Natural Therapies of Cancer. Oncothermia Journal 10:15-27
Blinova K, Dang Q, Millard D, Smith G, Pierson J, Guo L, Brock M, Lu HR, Kraushaar U, Zeng H, Shi H, Zhang X, Sawada K, Osada T, Kanda Y, Sekino Y, Pang L, Feaster TK, Kettenhofen R, Stockbridge N, Strauss DG, Gintant G ...
CNTN4: Contactin 4. *COL7A1: Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) ...
CONTACT- in-house magazine of OTC. Masterton, R and Prances M; Invisible Bridges, Australia and International ...
کانتکتین ۱ (انگلیسی: Contactin 1) یک پروتئین است که در انسان توسط ژن «CNTN۱» کُدگذاری می‌شود. پروتئینی که توسط این ژن ساخته ... Contactin 1. ». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۸ آوریل ۲۰۱۸. ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ...
Contactin-associated protein-like 2 is a protein that in humans is encoded by the CNTNAP2 gene. Since the most recent reference ... "Entrez Gene: CNTNAP2 contactin associated protein-like 2". Ashley, Euan A. (16 August 2016). "Towards precision medicine". ... Nakabayashi K, Scherer SW (April 2001). "The human contactin-associated protein-like 2 gene (CNTNAP2) spans over 2 Mb of DNA at ... Overview of all the structural information available in the PDB for UniProt: Q9UHC6 (Contactin-associated protein-like 2) at ...
Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene. This gene product belongs to ... "Entrez Gene: CNTNAP4 contactin associated protein-like 4". Human CNTNAP4 genome location and CNTNAP4 gene details page in the ...
... such as tenascin R and the cell-adhesion molecules neurofascin and contactin. Contactin is also present at nodes in the CNS and ... At CNS nodes, the axonal proteins also include contactin; however, Schwann cell microvilli are replaced by astrocyte perinodal ...
2001). «Contactin associates with Na+ channels and increases their functional expression.». J. Neurosci. 21 (19): 7517-25. PMID ... 2001). «Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent.». Eur. J. ... Berglund EO, Ranscht B (1994). «Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome ... Berglund EO, Ranscht B (1994). «Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome ...
Gollan L, Salomon D, Salzer JL, Peles E (December 2003). "Caspr regulates the processing of contactin and inhibits its binding ... "Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction". Current Biology. 12 ...
"Contactin-4 mediates axon-target specificity and functional development of the accessory optic system". Neuron. 86 (4): 985-999 ...
... members also bind "heterophilically" to members of the contactin or CNTN1 family. L1 family members bind to many ...
"Entrez Gene: Contactin associated protein 1". "OMIM Entry- * 602346 - CONTACTIN-ASSOCIATED PROTEIN 1; CNTNAP1". omim.org. ... "Contactin-Associated Protein (Caspr) and Contactin Form a Complex That Is Targeted to the Paranodal Junctions during ... CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 ... The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino ...
Bakkaloglu B, O'Roak BJ, Louvi A et al.. Molecular cytogenetic analysis and resequencing of Contactin Associated Protein-Like 2 ...
5 had antibodies against Contactin-2 and 18 (19%) had antibodies with unknown specificity. Of the patients with Contactin-2 ... 2010). "Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin- ... 19 had antibodies reacting with Contactin-associated protein 2 (CASPR 2), ...
This extracellular region is similar to the cell adhesion molecule contactin and other cell adhesion molecules. It is believed ...
In order to form a paranodal junction, Caspr and contactin form a complex with neurofascin 155. It has been shown that ... neurofascin 155 protein clusters then bring Caspr and contactin into the membrane to form the complex, which allows the ...
Shah BS, Rush AM, Liu S, Tyrrell L, Black JA, Dib-Hajj SD, Waxman SG (August 2004). "Contactin associates with sodium channel ...
Faivre-Sarrailh C, Banerjee S, Li J, Hortsch M, Laval M, Bhat MA (October 2004). "Drosophila contactin, a homolog of vertebrate ... contactin, is required for septate junction organization and paracellular barrier function". Development. 131 (20): 4931-42. ...
1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine ...
Schuko is an abbreviation for the German word Schutzkontakt, which means "Protective contact" - in this case "protective" ...
... beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ...
Autoantibodies to components of the Ranvier nodes, specially autoantibodies the Contactin-associated protein 1 (CASPR), cause a ... contactin-1 and caspr-1. These cases are special not only because of their pathology, but also because they are non-responsive ...
Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: ...
... contactin 1 (CNTN1), contactin associated protein 1 (CASPR1) and gliomedin. All of them nodal and paranodal proteins. Anti-TNF ...
... such as F3/contactin. In the nematode C. elegans, two genes encode homologous proteins, glp-1 and lin-12. There has been at ...
... may not be touched by human contact - in some cases, not even approached. A person, object or a place could be made sacred by ...
... as well as the neuronal molecules contactin and Thy-1 (CD90). Quite surprisingly, the alpha toxin of C. septicum is not related ...
The first report about a subgroup of MS patients with anti-NF and contactin 2 auto-antibodies was published in 2011 J. Ciron et ...
... glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired ...
2009). "Molecular genetic analysis of a cell adhesion molecule with homology to L1CAM, contactin 6, and contactin 4 candidate ...
The first one is accumulation of TAS effectors in tissue (comutons, chalones, and contactins), which possess a unique feature ... chalones and contactins, which are produced by the cells of a tissue under a stressor's influence. This distinguishes the ...
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the ... The subgroup consists of six members now referred to as contactin 1-6, but historically they had different names as shown in ... the table below: Shimoda, Yasushi; Watanabe, Kazutada (1 January 2009). "Contactins". Cell Adh Migr. 3 (1): 64-70. PMC 2675151 ...
Contactin-3 is a protein that in humans is encoded by the CNTN3 gene. GRCh38: Ensembl release 89: ENSG00000113805 - Ensembl, ... "Entrez Gene: CNTN3 contactin 3 (plasmacytoma associated)". Human CNTN3 genome location and CNTN3 gene details page in the UCSC ... 2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression ...
In association with contactin, it may have a role in the signaling between axons and myelinating glial cells [PMID: 9118959, ... Contactin-associated protein 1 (also known as paranodin or caspr1) has a key role in the formation of the paranodal junctions ... Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4- ... Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein ...
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity ... Contactin family.Curated. Keywords - Domaini. Immunoglobulin domain, Repeat, Signal. Phylogenomic databases. evolutionary ... IPR032989, Contactin-5. IPR003961, FN3_dom. IPR036116, FN3_sf. IPR007110, Ig-like_dom. IPR036179, Ig-like_dom_sf. ... IPR032989, Contactin-5. IPR003961, FN3_dom. IPR036116, FN3_sf. IPR007110, Ig-like_dom. IPR036179, Ig-like_dom_sf. ...
Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by ... IPR033009. Contactin-6. IPR003961. FN3_dom. IPR036116. FN3_sf. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig ... IPR033009. Contactin-6. IPR003961. FN3_dom. IPR036116. FN3_sf. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig ... Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by ...
Browse our Contactin-2/TAG1 Lysate catalog backed by our Guarantee+. ... contactin 2 (axonal) lysate, contactin 2 (transiently expressed) lysate, contactin-2 lysate, DKFZp781D102 lysate, FLJ37193 ... Our Contactin-2/TAG1 Lysates can be used in a variety of model species. Use the list below to choose the Contactin-2/TAG1 ... We offer Contactin-2/TAG1 Lysates for use in common research applications: Western Blot. Each Contactin-2/TAG1 Lysate is fully ...
View our 9 Contactin-1 products for your research including Contactin-1 Primary Antibodies, Proteins and Enzymes, cDNA Clones, ... Contactin-2 (TAX-1 in human, TAG1 in rat, and Axonin-1 in chicken), Contactin-4 (BIG-1), Contactin-5 (NB-2), and Contactin-6 ( ... Contactin-1: Products. Contactin-1 (also known as Contactin in human, F3 in rodent, and F11 in chicken), ... NB-3) form the contactin subgroup of cell adhesion molecules within the immunoglobulin superfamily. Contactin-1 and -2 are ...
Contactin expression in cultured OPCs 1-4 d after transfection with control and contactin (F3) siRNAs. Note that the contactin ... Contactin is required for L1- and laminin-induced Fyn activation. A, Expression of contactin and Fyn and the level of Fyn ... Contactin expression in oligodendrocytes. A, Western blot for contactin expression in OPCs at the time of plating or after ... B, Survival of OPCs transfected with contactin or control siRNA duplexes and analyzed as in Figure 4. Note that contactin ...
View mouse Cntnap4 Chr8:112570043-112882717 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Invitrogen Anti-Contactin 5 Polyclonal, Catalog # PA5-58814. Tested in Western Blot (WB), Immunofluorescence (IF), ... Cite Contactin 5 Polyclonal Antibody. The following product was used in this experiment: Contactin 5 Polyclonal Antibody from ... Immunofluorescent staining of Contactin 5 in human cell line U-2 OS shows positivity in cytoplasm. Samples were probed using a ... Immunohistochemical staining of Contactin 5 in human kidney tissue shows strong cytoplasmic positivity in tubular cells. ...
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
While the exact function of CNTN5 is yet to be fully characterized, its paralogs contactin 1 and contactin 2 are known to be ... The CNTN5 gene encodes contactin 5, a member of the immunoglobulin/fibronectin superfamily of adhesion molecules. CNTN5 is a ... glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein and like other contactins, it mediates cell surface ...
Immunohistochemistry Shop Contactin 6 Rabbit anti-Rat, Polyclonal, Invitrogen™ ... Contactin 6 Antibody, PA1-18251, from Invitrogen™. Species Reactivity: Rat; Applications: ... The neural adhesion molecule Contactin-6, also known as NB-3, is a contactin/F3 subgroup member of immunoglobulin superfamily. ... Synthetic peptide corresponding to residues K L H K M S S L S S V G V Q I L K P S T Q F of rat contactin-6.. ...
No effect of genetic deletion of contactin-associated protein (CASPR) on axonal orientation and synaptic plasticity.. Pillai AM ... No Effect of Genetic Deletion of Contactin-Associated Protein (CASPR) on Axonal Orientation and Synaptic Plasticity ... No Effect of Genetic Deletion of Contactin-Associated Protein (CASPR) on Axonal Orientation and Synaptic Plasticity ... No Effect of Genetic Deletion of Contactin-Associated Protein (CASPR) on Axonal Orientation and Synaptic Plasticity ...
KDs: contactin 4-APP, 17 nM; contactin 4-APLP1, 28 nM; contactin 3-APP, 22 nM; contactin 3-APLP1, 35 nM; and contactin 5-APLP1 ... Our studies show that APP binds both contactin 3 and 4. APLP1 was found to bind contactins 3 and 4, and also contactin 5. These ... On contactin 4, the APP-binding site localizes to the FN-like domains, which could leave the Ig domains of contactin free to ... APP and APLP1 bind to specific contactin family members. (A) AP fusion proteins were tested for binding to contactin-Fc fusion ...
A 180-kDa polyprotein was selectively precipitated by the patient serum (figure 1C) and identified as contactin-associated ... Here we have identified a potentially pathogenic antibody against the neuronal membrane protein contactin-associated protein 2 ... Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated ... which resulted in the identification of contactin-associated protein 2 (CASPR2) as a major antigen. CASPR2 antibodies were then ...
Recombinant Contactin 2 (Axonal) (CNTN2) Protein (His tag). Species: Human. Source: Escherichia coli (E. coli). Order product ... Contactin 2 (Axonal) (CNTN2) (AA 877-1040) protein (His tag) Protein CNTN2 Origin: Human Source: Escherichia coli (E. coli) ... Contactin 2 (Axonal) (CNTN2) (AA 802-1008) protein (T7 tag,His tag) Protein ...
... and Contactin-Associated Protein-Like 2 (CNTNAP2) in particular, have been widely cited as autism risk genes based on findings ...
Anti-contactin-1-associated neuropathy does not meet morphological criteria of demyelinating neuropathy and therefore, might ... Methods We used ELISA to detect autoantibodies against contactin-1. Specificity of the autoantibodies was confirmed by ... Results High reactivity to contactin-1 by ELISA was found in four patients with chronic inflammatory demyelinating ... Interpretation We conclude that anti-contactin-1-related neuropathy constitutes a presumably autoantibody-mediated form of ...
... is an axonal cell adhesion molecule that belongs to the contactin family. This protein has the ability to promote neurite ... Contactin family proteins exist as membranebound proteins, but can also be released as soluble proteins by GPIspecific ... Rat hippocampal neurons grown on microplates pre-coated with human Contactin-4 ... Rat hippocampal neurons grown on microplates pre-coated with human Contactin-4 ...
Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse ... Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse ... Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse ... CNTN1 / gp135 / Contactin 1 Antibody (aa81‑130, FITC) LS‑C466250 Species: Human, Chimpanzee, Orangutan, Gibbon, Monkey, Rat, ...
Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). Validated ... Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). Validated ... Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). Validated ... CNTN1 / gp135 / Contactin 1 Antibody (aa81‑130, FITC) LS‑C466250 Species: Human, Chimpanzee, Orangutan, Gibbon, Monkey, Rat, ...
Contactin 6 / NB-3 (mouse aa160-172) Antibody (internal region), Peptide-affinity purified goat antibody validated in E ( ... Contactin-6, Neural recognition molecule NB-3, hNB-3, CNTN6. Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with ... Contactin 6 / NB-3 (mouse aa160-172) Antibody (internal region) is for research use only and not for use in diagnostic or ... home , Products , Primary Antibodies , Antibody Collections , Goat Antibodies , Contactin 6 / NB-3 (mouse aa160-172) Antibody ( ...
Contactin 4 / Big-2 (mouse aa160-172) Antibody (internal region), Peptide-affinity purified goat antibody validated in WB, E ( ... Contactin-4, Brain-derived immunoglobulin superfamily protein 2, BIG-2, CNTN4. Format 0.5 mg/ml in Tris saline, 0.02% sodium ... Contactin 4 / Big-2 (mouse aa160-172) Antibody (internal region) is for research use only and not for use in diagnostic or ... home , Products , Primary Antibodies , Antibody Collections , Goat Antibodies , Contactin 4 / Big-2 (mouse aa160-172) Antibody ...
Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA - 10 µg - OriGene ... home , products , origene , myc-ddk-tagged orf clone of homo sapiens contactin 1 (cntn1), transcript variant 1 as transfection- ... Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA - RC214706 - 10 µg ... TrueORF Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA ...
Plagge, A; Sendtner-Voelderndorff, L; Sirim, P; Freigang, J; Rader, C; Sonderegger, P; Brümmendorf, T (2001). The contactin- ... FAR-2 is a novel neural member of the Ig superfamily, which is related to F11/F3/contactin and axonin-1/TAG-1. This protein is ... FAR-2 is a novel neural member of the Ig superfamily, which is related to F11/F3/contactin and axonin-1/TAG-1. This protein is ... The contactin-related protein FAR-2 defines purkinje cell clusters and labels subpopulations of climbing fibers in the ...
... sequence analysis revealed the variations to have resulted from Alu Y mediated unequal recombinations interrupting contactin 4 ... Contactin-1/F3 Regulates Neuronal Migration and Morphogenesis Through Modulating RhoA Activity. Taiping Chen, I Lu, J Tsai ... Disruption of Contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome.. Thomas Fernandez ... Morphophysiological effects of insertional mutagenesis of the contactin 5 (Cntn5) gene in transgenic mice. Alexander V Smirnov ...
... myr-PTPα/contactin (myr-α/cont), or PTPα/contactin (α/cont) were probed for PTPα and contactin. (B) Whole cell lysates (WCL) ... myr-PTPα/contactin (myr-α/cont), or PTPα/contactin (α/cont) were probed for PTPα and contactin. (B) Whole cell lysates (WCL) ... Coclusters of contactin and PTPα could also be induced by 4D1 mAb specific for contactin ( Fig. 3C and Fig. D). Clusters of ... PTPα and Contactin Are Associated in Chick Brain. Contactin and PTPα immunoprecipitates from embryonic chick brain lysates were ...
Quantitative Analysis of Contactin-Associated Protein and Voltage-Gated Sodium Channel Isoform 1.6 following Experimental ...
Out of the six isoforms of contactins found in vertebrates (contactin-1,-2,-3,-4,-5, and -6), only contactin-6 was identified ... Contactins. As part of the immunoglobulin cell adhesion molecules, contactins extracellular region consists of immunoglobulin- ... Although contactins lack a transmembrane domain, they are linked to the cell surface via a GPI anchor, a feature that allows ... Contactins have been shown to form molecular complexes with various transmembrane proteins therefore allowing them to provide a ...
  • Contactin-3 is a protein that in humans is encoded by the CNTN3 gene. (wikipedia.org)
  • Contactin-associated protein 1 (also known as paranodin or caspr1) has a key role in the formation of the paranodal junctions and is required for normal saltatory conduction [ PMID: 11395000 ]. (ebi.ac.uk)
  • Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. (ebi.ac.uk)
  • Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors. (ebi.ac.uk)
  • The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. (thermofisher.com)
  • CNTN5 is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein and like other contactins, it mediates cell surface interactions during nervous system development. (cags.org.ae)
  • No effect of genetic deletion of contactin-associated protein (CASPR) on axonal orientation and synaptic plasticity. (nih.gov)
  • In vitro binding studies revealed direct interactions among multiple members of the APP and contactin protein families. (biologists.org)
  • One strong-binding serum was selected for immunoprecipitation and mass spectrometry, which resulted in the identification of contactin-associated protein 2 (CASPR2) as a major antigen. (bmj.com)
  • Here we have identified a potentially pathogenic antibody against the neuronal membrane protein contactin-associated protein 2 (CASPR2) in nine of 88 (10%) patients with unexplained ataxia. (bmj.com)
  • Recombinant Human Contactin-4 or CNTN4 Protein. (neuromics.com)
  • Contactin 1 Polyclonal Antibody detects endogenous levels of Contactin 1 protein. (lsbio.com)
  • The contactin-related protein FAR-2 defines purkinje cell clusters and labels subpopulations of climbing fibers in the developing cerebellum. (uzh.ch)
  • Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. (semanticscholar.org)
  • There are 5 Contactin 3 protein produced in house with high quality which are covering various species. (sinobiological.com)
  • Among these Contactin 3 proteins, there are 2 Human Contactin 3 protein, 1 Mouse Contactin 3 protein, 2 Rat Contactin 3 protein. (sinobiological.com)
  • All these Contactin 3 protein are expressed by different host cells. (sinobiological.com)
  • CNTN2 (Contactin 2) is a Protein Coding gene. (genecards.org)
  • CNTN6 (Contactin 6) is a Protein Coding gene. (genecards.org)
  • Recombinant Contactin 3 Protein, Rat (Fc Tag) Recombinant Proteins The rat CNTN3 (Met1-Gly1001) was expressed with the Fc region of human IgG1 at the C-terminus The recombinant rat CNTN3/Fc is a disulfide-linked homodimer. (thebiotek.com)
  • Contactin-associated protein 4 (Caspr4), also known as contactin-associated protein-like protein (CNTNAP4), is normally portrayed in several regions of the brain. (angiogenesis-blog.com)
  • Contactin-associated proteins 4 (Caspr4), also known as contactin-associated protein-like proteins (CNTNAP4), is normally a transmembrane proteins member of the neurexin superfamily included in neuronCglia connections and the clustering of T+ stations in myelinated axons [13C17]. (angiogenesis-blog.com)
  • Protein-tyrosine phosphatase receptor type G (RPTPγ/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system. (rcsb.org)
  • We studied the molecular sites of interaction between human contactin 4, -5 or -6 and the human Protein Tyrosine Phosphatase Receptor Gamma (PTPRG), a contactin partner, by modeling their 3D structures. (pasteur.fr)
  • Association of Leucine-Rich Glioma Inactivated Protein 1, Contactin-Associated Protein 2, and Contactin 2 Antibodies With Clinical Features and Patient-Reported Pain in Acquired Neuromyotonia. (ox.ac.uk)
  • Importance: Although acquired autoimmune neuromyotonia (NMT) is associated with voltage-gated potassium channel (VGKC)-complex antibodies, to date there has been no systematic study of autoantibodies to the specific antigens leucine-rich glioma inactivated protein 1 (LGI1), contactin-associated protein 2 (CASPR2), and contactin 2 together with the full clinical syndrome, particularly pain and autonomic and central nervous system involvement. (ox.ac.uk)
  • We use a single molecule atomic force spectroscopy combined with the steered molecular dynamics simulation to determine a mechanical behavior of neural cell adhesion protein contactin during its unfolding. (edu.pl)
  • METHODS: Antibodies to neurofascin-155 (Nfasc155), neurofascin-140/186 (Nfasc140/186), contactin-1 (CNTN1), and contactin-associated protein 1 (Caspr1) were detected with ELISA and/or cell-based assay. (elsevier.com)
  • Contactin-2 is a synaptic and axonal membrane protein that interacts with proteins involved in the pathology of AD such as amyloid precursor protein (APP) and beta-secretase 1 (BACE1). (biomedcentral.com)
  • We developed a FCS set-up for contactin-2, a neuronal cell adhesion molecule and a ligand of beta-secretase 1 (BACE1) and amyloid precursor protein (APP), the latter proteins being important players in AD. (vumc.nl)
  • Using mouse models, the researchers demonstrate that image stabilization depends upon two proteins, Contactin-4 and amyloid precursor protein, binding during embryonic development. (eurekalert.org)
  • On the other hand, when they added Contactin-4 to a cell that doesn't normally produce it, that one additional protein was all the cell needed make the circuits for a steady eye-brain connection. (eurekalert.org)
  • If amyloid precursor protein isn't available, the researchers discovered, Contactin-4 can't control development of the visual circuitry. (eurekalert.org)
  • Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. (nature.com)
  • In sciatic nerve, the expression of contactin, receptor protein tyrosine phosphatase β, and the Na + -channel β 1 subunit, paranodal caspr and nodal ankyrin G was unaltered in 2-month type 1 diabetic BB/Wor rats but significantly decreased after 8 months of diabetes. (diabetesjournals.org)
  • Shows that the stabilization of the Caspr/contactin complex at the cell membrane requires the intracellular region, which includes the protein 4.1B-binding domain). (scorcher.ru)
  • The contactin family comprises six members (CNTN1/F3, CNTN2/TAG1, CNTN3/BIG1, CNTN4/BIG2, CNTN5/NB2 and CNTN6/NB3) and are characterized by the presence of six Ig like domains, four fibronectin type III like repeats, and a glycosylphosphatidylinositol (GPI) anchoring domain. (neuromics.com)
  • Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse and rat. (lsbio.com)
  • Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). (lsbio.com)
  • Co-precipitation from these tissues and tandem mass spectrometry led to the identification of two associated proteins: contactin 4 and NgCAM. (biologists.org)
  • Functional assays revealed regulatory effects of both APP and contactin 4 on NgCAM-dependent growth of cultured retinal axons, demonstrating specific functional interactions among these proteins. (biologists.org)
  • These studies identify novel binding and functional interactions among proteins of the APP, contactin and L1CAM families, with general implications for mechanisms of APP action in neural development and disease. (biologists.org)
  • Contactin family proteins exist as membranebound proteins, but can also be released as soluble proteins by GPIspecific phospholipase D. Soluble Contactins are functionsl proteins that are able to promote neurite outgrowth. (neuromics.com)
  • These Contactin 3 proteins are produced with different tags, such as His Tag, Fc Tag. (sinobiological.com)
  • This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. (nih.gov)
  • Then the team went looking for proteins that bind Contactin-4. (eurekalert.org)
  • The following product was used in this experiment: Contactin 5 Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-58814, RRID AB_2640053. (thermofisher.com)
  • This complex is stable to isolation from brain lysates or transfected cells through immunoprecipitation and to antibody-induced coclustering of PTPα and contactin within cells. (rupress.org)
  • Main Outcomes and Measures: Clinical data and scores on the modified Rankin Scale (mRS), which measures disability on a range of 0 to 6, with 0 indicating normal and 6 indicating death, before and after treatments were combined with CASPR2, LGI1, and contactin 2 antibody status. (ox.ac.uk)
  • Contactin4 (CNTN4), also known as BIG2 (Brainderived Immunoglobulin Superfamily molecule 2), is an axonal cell adhesion molecule that belongs to the contactin family, a subfamily of the Ig superfamily (1 3). (neuromics.com)
  • Disruption of Contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome. (semanticscholar.org)
  • Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. (wikipedia.org)
  • C ontactin-1 (also known as Contactin in human, F3 in rodent, and F11 in chicken), Contactin-2 (TAX-1 in human, TAG1 in rat, and Axonin-1 in chicken), Contactin-4 (BIG-1), Contactin-5 (NB-2), and Contactin-6 (NB-3) form the contactin subgroup of cell adhesion molecules within the immunoglobulin superfamily. (rndsystems.com)
  • The CNTN5 gene encodes contactin 5, a member of the immunoglobulin/fibronectin superfamily of adhesion molecules. (cags.org.ae)
  • The neural adhesion molecule Contactin-6, also known as NB-3, is a contactin/F3 subgroup member of immunoglobulin superfamily. (fishersci.ca)
  • Contactin-3 contains 4 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. (thebiotek.com)
  • Contactins (Cntns) are a six-member subgroup of the immunoglobulin cell adhesion molecule superfamily (IgCAMs) with pronounced brain expression and function. (uu.nl)
  • Contactin-3, also known as CNTN3 ( BIG-1 in rat and PANG in mouse ), is a GPI-linked glycoprotein that is expressed on cerebellar Purkinje cells, amygdaloid and thalamic neurons and olfactory granule cells. (thebiotek.com)
  • 2001). «Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent. (wikipedia.org)
  • Transgenic mice expressing F3/contactin from the Transient Axonal Glycoprotein promoter undergo developmentally regulated deficits of the cerebellar function. (uniroma1.it)
  • We have shown that transgenic transient axonal glycoprotein (TAG)/F3 mice, in which the mouse axonal glycoprotein F3/contactin was misexpressed from a regulatory region of the gene encoding the transient axonal glycoprotein TAG-1, exhibit a transient disruption of cerebellar granule and Purkinje cell development [Development 130 (2003) 29]. (uniroma1.it)
  • Contactin, a glycosyl-phosphatidylinositol (GPI)-anchored predominantly neuronal cell surface glycoprotein, associates with sodium channels Nav1.2, Nav1.3 and Nav1.9, and enhances the density of these channels on the plasma membrane in mammalian expression systems. (qxmd.com)
  • While the exact function of CNTN5 is yet to be fully characterized, its paralogs contactin 1 and contactin 2 are known to be involved in neural cell migration, axon guidance and myelin subdomain organization. (cags.org.ae)
  • FAR-2 is a novel neural member of the Ig superfamily, which is related to F11/F3/contactin and axonin-1/TAG-1. (uzh.ch)
  • The neural cell-adhesion molecules contactin 4, contactin 5 and contactin 6 are involved in brain development, and disruptions in contactin genes may confer increased risk for autism spectrum disorders (ASD). (pasteur.fr)
  • Identification and characterization of the human cell adhesion molecule contactin. (wikipedia.org)
  • From this, the team found Contactin-4, an adhesion molecule. (eurekalert.org)
  • The subgroup consists of six members: Contactin-1, Contactin-2(TAG-1), Contactin-3(BIG-1), BIG-2, Contactin-5(NB-2) and NB-3. (thebiotek.com)
  • We first demonstrate that the Ig superfamily molecule contactin is associated in oligodendrocytes with integrins, extracellular matrix receptors that regulate target-dependent survival by amplification of growth factor signaling. (jneurosci.org)
  • Methods We used ELISA to detect autoantibodies against contactin-1. (bmj.com)
  • Results High reactivity to contactin-1 by ELISA was found in four patients with chronic inflammatory demyelinating polyradiculoneuropathy and in none of the patients with Guillain-Barré syndrome, which was confirmed by cell binding assays in all four patients. (bmj.com)
  • Specificity of the autoantibodies was confirmed by immunoblot assay, binding to contactin-1-transfected human embryonic kidney cells, binding to paranodes of murine teased fibres and preabsorption experiments. (bmj.com)
  • In contrast, the presence of L1-Fc, the extracellular portion of a contactin ligand expressed on axons, enhanced survival and additionally promoted myelination in cocultures of neurons and oligodendrocytes. (jneurosci.org)
  • 1995). «The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin. (wikipedia.org)
  • Contactin is a noncanonical Notch receptor ligand that mediates oligodendrocyte differentiation. (jci.org)
  • 2001). «Contactin associates with Na+ channels and increases their functional expression. (wikipedia.org)
  • Biochemical characterizations of the paranodal axoglial SJs have identified several molecular components that include Caspr and contactin (Cont) on the axonal side and neurofascin 155 kDa (NF155) isoform on the glial side. (nih.gov)
  • For example, since the Contactin-4 gene is located in a cluster of genes that have been implicated in some forms of autism, they want to know if aberrations in that particular gene might play a role in development of the disease. (eurekalert.org)
  • Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. (thebiotek.com)
  • We describe a co-culture of rat cortical neurons and HEK293 cells overexpressing and delivering the secreted forms of rat contactin 4-6. (pasteur.fr)
  • We examined the expression and function of sodium channels in small-diameter dorsal root ganglion (DRG) neurons from contactin-deficient (CNTN-/-) mice, compared to CNTN+/+ litter mates. (qxmd.com)
  • We hypothesized that AD might be characterized by changes in contactin-2 levels in the cerebrospinal fluid (CSF) and brain tissue. (biomedcentral.com)
  • Contactin-1 and -2 are differentially expressed in a number of neuronal tissues during development and interact with several ligands including Nr-CAM, L1, NCAM, neurocan, phosphacan, and tenascin. (rndsystems.com)
  • We demonstrate that PTPα, an RPTP that dephosphorylates and activates src family kinases, forms a novel membrane-spanning complex with the neuronal GPI-anchored receptor contactin. (rupress.org)
  • 1997). «Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta.» . (wikipedia.org)
  • show that Contactin is abundantly expressed on demyelinated axons in human chronic MS lesions and that Notch1 is activated in oligodendrocyte precursor cells (see the related article beginning on page 169). (jci.org)
  • Taken together, these data reveal that the contactin-2 changes observed in tissues are reflected in CSF, suggesting that decreased contactin-2 CSF levels might be a biomarker reflecting synaptic or axonal loss. (biomedcentral.com)
  • Contactin-3 may mediate cell-cell interaction and may promote neurite outgrowth. (thebiotek.com)
  • We conclude, therefore, that a novel integrin/contactin complex coordinates signals from extracellular matrix and the axonal surface to regulate both oligodendrocyte survival and myelination by controlling Fyn activity. (jneurosci.org)
  • Immunohistochemical analysis revealed that contactin-2 is expressed in the extracellular matrix. (biomedcentral.com)
  • We offer Contactin-2/TAG1 Lysates for use in common research applications: Western Blot. (novusbio.com)
  • Each Contactin-2/TAG1 Lysate is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Our Contactin-2/TAG1 Lysates can be used in a variety of model species. (novusbio.com)
  • Choose from our Contactin-2/TAG1 Lysates. (novusbio.com)
  • The PA1-18251 immunogen is a synthetic peptide corresponding to residues K L H K M S S L S S V G V Q I L K P S T Q F of rat contactin-6, conjugated to KLH. (fishersci.ca)
  • This amplification is inhibited by small interfering RNA-mediated knockdown of contactin in oligodendrocytes. (jneurosci.org)
  • Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma. (nature.com)
  • Synthesized peptide derived from human Contactin 1. (lsbio.com)
  • Human Contactin-3 shares 92% aa identity with mouse Contactin-3.The exact function of Contactin-3 is unclear. (thebiotek.com)
  • However, interactive residues between human contactin 4-6 and PTPRG were strictly conserved. (pasteur.fr)
  • We further characterized the expression of contactin-2 in postmortem AD human brain ( n = 14) versus nondemented controls ( n = 9). (biomedcentral.com)
  • Contactins mediate cell surface interactions during nervous system development. (uniprot.org)
  • The transmembrane and catalytic nature of PTPα indicate that it likely forms the transducing element of the complex, and we postulate that the role of contactin is to assemble a phosphorylation-competent system at the cell surface, conferring a dynamic signal transduction capability to the recognition element. (rupress.org)
  • This mode of membrane attachment precludes direct transfer of signals into the cell, but allows high mobility in the plane of the membrane, and as such ideally suits contactin for responding to macromolecular stimuli presented to the cell ( Vaughan 1996 ). (rupress.org)
  • Lower levels of contactin-2 were specifically found in and around amyloid plaques in AD hippocampus and temporal cortex. (biomedcentral.com)
  • We did not observe any differences in PTPRG binding on contactin 5 and -6 either. (pasteur.fr)
  • We describe the clinical phenotype and histopathological changes of paranodal architecture of patients with autoantibodies against contactin-1, identified from a cohort with chronic inflammatory demyelinating polyradiculoneuropathy (n=53) and Guillain-Barré syndrome (n=21). (bmj.com)
  • Interpretation We conclude that anti-contactin-1-related neuropathy constitutes a presumably autoantibody-mediated form of inflammatory neuropathy with distinct clinical symptoms and disruption of paranodal architecture as a pathological correlate. (bmj.com)
  • 2000). «Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression. (wikipedia.org)