Contactins
Oligodendroglia
A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.
Myelin Sheath
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
Demyelinating Diseases
Laminin
Cell Survival
Schwann Cells
Contactin 1
Cell Adhesion Molecules, Neuronal
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Contactin 2
Mutism
The inability to generate oral-verbal expression, despite normal comprehension of speech. This may be associated with BRAIN DISEASES or MENTAL DISORDERS. Organic mutism may be associated with damage to the FRONTAL LOBE; BRAIN STEM; THALAMUS; and CEREBELLUM. Selective mutism is a psychological condition that usually affects children characterized by continuous refusal to speak in social situations by a child who is able and willing to speak to selected persons. Kussmal aphasia refers to mutism in psychosis. (From Fortschr Neurol Psychiatr 1994; 62(9):337-44)
Child Development Disorders, Pervasive
Antibodies
Antibody Specificity
Authorship
Knowledge Bases
Editorial Policies
Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
A slowly progressive autoimmune demyelinating disease of peripheral nerves and nerve roots. Clinical manifestations include weakness and sensory loss in the extremities and enlargement of peripheral nerves. The course may be relapsing-remitting or demonstrate a step-wise progression. Protein is usually elevated in the spinal fluid and cranial nerves are typically spared. GUILLAIN-BARRE SYNDROME features a relatively rapid progression of disease which distinguishes it from this condition. (Adams et al., Principles of Neurology, 6th ed, p1337)
Polyradiculoneuropathy
Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (GUILLAIN-BARRE SYNDROME) and POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots.
Guillain-Barre Syndrome
An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)
Tremor
Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.
Plasma Exchange
Neurology
Goats
Protein Tyrosine Phosphatases
Protein Tyrosine Phosphatase, Non-Receptor Type 1
A subtype of non-receptor protein tyrosine phosphatases that includes two distinctive targeting motifs; an N-terminal motif specific for the INSULIN RECEPTOR, and a C-terminal motif specific for the SH3 domain containing proteins. This subtype includes a hydrophobic domain which localizes it to the ENDOPLASMIC RETICULUM.
Receptor-Like Protein Tyrosine Phosphatases
A subcategory of protein tyrosine phosphatases that are bound to the cell membrane. They contain cytoplasmic tyrosine phosphatase domains and extracellular protein domains that may play a role in cell-cell interactions by interacting with EXTRACELLULAR MATRIX components. They are considered receptor-like proteins in that they appear to lack specific ligands.
Analysis of receptor binding by the channel-forming toxin aerolysin using surface plasmon resonance. (1/114)
Aerolysin is a channel-forming bacterial toxin that binds to glycosylphosphatidylinositol (GPI) anchors on host cell-surface structures. The nature of the receptors and the location of the receptor-binding sites on the toxin molecule were investigated using surface plasmon resonance. Aerolysin bound to the GPI-anchored proteins Thy-1, variant surface glycoprotein, and contactin with similar rate constants and affinities. Enzymatic removal of N-linked sugars from Thy-1 did not affect toxin binding, indicating that these sugars are not involved in the high affinity interaction with aerolysin. Aerolysin is a bilobal protein, and both lobes were shown to be required for optimal binding. The large lobe by itself bound Thy-1 with an affinity that was at least 10-fold weaker than that of the whole toxin, whereas the small lobe bound the GPI-anchored protein at least 1000-fold more weakly than the intact toxin. Mutation analyses provided further evidence that both lobes were involved in GPI anchor binding, with certain single amino acid substitutions in either domain leading to reductions in affinity of as much as 100-fold. A variant with single amino acid substitutions in both lobes of the protein was completely unable to bind the receptor. The membrane protein glycophorin, which is heavily glycosylated but not GPI-anchored, bound weakly to immobilized proaerolysin, suggesting that interactions with cell-surface carbohydrate structures other than GPI anchors may partially mediate toxin binding to host cells. (+info)Functional interactions of the immunoglobulin superfamily member F11 are differentially regulated by the extracellular matrix proteins tenascin-R and tenascin-C. (2/114)
The axon-associated protein F11 is a GPI-anchored member of the immunoglobulin superfamily that promotes axon outgrowth and that shows a complex binding pattern toward multiple cell surface and extracellular matrix proteins including tenascin-R and tenascin-C. In this study, we demonstrate that tenascin-R and tenascin-C differentially modulate cell adhesion and neurite outgrowth of tectal cells on F11. While soluble tenascin-R increases the number of attached cells and the percentage of cells with neurites on immobilized F11, tenascin-C stimulates cell attachment to a similar extent but decreases neurite outgrowth. The cellular receptor interacting with F11 has been previously identified as NrCAM; however, in the presence of tenascin-R or tenascin-C cell attachment and neurite extension are independent of NrCAM. Antibody perturbation experiments indicate that beta(1) integrins instead of NrCAM function as receptor for neurite outgrowth of tectal cells on an F11.TN-R complex. Cellular binding assays support the possibility that the interaction of F11 to NrCAM is blocked in the presence of tenascin-R and tenascin-C. Furthermore, a sandwich binding assay demonstrates that tenascin-R and tenascin-C are able to form larger molecular complexes and to link F11 polypeptides by forming a molecular bridge. These results suggest that the molecular interactions of F11 might be regulated by the presence of tenascin-R and tenascin-C. (+info)NrCAM, cerebellar granule cell receptor for the neuronal adhesion molecule F3, displays an actin-dependent mobility in growth cones. (3/114)
The neuronal adhesion glycoprotein F3 is a multifunctional molecule of the immunoglobulin superfamily that displays heterophilic binding activities. In the present study, NrCAM was identified as the functional receptor mediating the inhibitory effect of F3 on axonal elongation from cerebellar granule cells. F3Fc-conjugated microspheres binding to neuronal growth cones resulted from heterophilic interaction with NrCAM but not with L1. Time-lapse video-microscopy indicated that F3Fc beads bind at the leading edge and move retrogradely to reach the base of the growth cone within a lapse of 30-60 seconds. Such velocity (5.7 microm/minute) is consistent with a coupling between F3 receptors and the retrograde flow of actin filaments. When actin filaments were disrupted by cytochalasin B, the F3Fc beads remained immobile at the leading edge. The retrograde mobility appeared to be dependent on NrCAM clustering since it was induced upon binding with cross-linked but not dimeric F3Fc chimera. These data indicate that F3 may control growth cone motility by modulating the linkage of its receptor, NrCAM, to the cytoskeleton. They provide further insights into the mechanisms by which GPI-anchored adhesion molecules may exert an inhibitory effect on axonal elongation. (+info)Pathological missense mutations of neural cell adhesion molecule L1 affect homophilic and heterophilic binding activities. (4/114)
Mutations in the gene for neural cell adhesion molecule L1 (L1CAM) result in a debilitating X-linked congenital disorder of brain development. At the neuronal cell surface L1 may interact with a variety of different molecules including itself and two other CAMs of the immunoglobulin superfamily, axonin-1 and F11. However, whether all of these interactions are relevant to normal or abnormal development has not been determined. Over one-third of patient mutations are single amino acid changes distributed across 10 extracellular L1 domains. We have studied the effects of 12 missense mutations on binding to L1, axonin-1 and F11 and shown for the first time that whereas many mutations affect all three interactions, others affect homophilic or heterophilic binding alone. Patient pathology is therefore due to different types of L1 malfunction. The nature and functional consequence of mutation is also reflected in the severity of the resultant phenotype with structural mutations likely to affect more than one binding activity and result in early mortality. Moreover, the data indicate that several extracellular domains of L1 are required for homophilic and heterophilic interactions. (+info)Compartmentation of Fyn kinase with glycosylphosphatidylinositol-anchored molecules in oligodendrocytes facilitates kinase activation during myelination. (5/114)
In many cell types, glycosylphosphatidylinositol (GPI)-anchored proteins are sequestered in detergent-resistant membrane rafts. These are plasma membrane microdomains enriched in glycosphingolipids and cholesterol and are suggested to be platforms for cell signaling. Concomitant with the synthesis of myelin glycosphingolipids, maturing oligodendrocytes progressively associate GPI-anchored proteins, including the adhesion molecules NCAM 120 and F3, in rafts. Here we show that these microdomains include Fyn and Lyn kinases. Both kinases are maximally active in myelin prepared from young animals, correlating with early stages of myelination. In the rafts, Fyn kinase is tightly associated with NCAM 120 and F3. In contrast, in oligodendrocyte progenitor cells lacking rafts or in raft-free membrane domains of more mature cells, F3 does not associate with Fyn. The addition of anti-F3 antibodies to oligodendrocytes results in stimulation of Fyn kinase specifically in rafts. Compartmentation of oligodendrocyte GPI-anchored proteins in rafts is thus a prerequisite for association with Fyn, permitting kinase activation. Interaction of oligodendrocyte F3 with axonal ligands such as L1 and ensuing kinase activation may play a crucial role in initiating myelination. (+info)Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein. (6/114)
Lipid rafts are regions of the plasma membrane that are enriched in cholesterol, glycosphingolipids and acylated proteins, and which have been proposed as sites for the proteolytic processing of the Alzheimer's amyloid precursor protein (APP). Lipid rafts can be isolated on the basis of their insolubility in Triton X-100 at 4 degrees C, with the resulting low-density, detergent-insoluble glycolipid-enriched fraction (DIG) being isolated by flotation through a sucrose density gradient. The detergent-insolubility of APP in mouse cerebral cortex relative to a variety of DIG marker proteins (alkaline phosphatase, flotillin, F3 protein and prion protein) and non-DIG proteins (alkaline phosphodiesterase I, aminopeptidase A and clathrin) has been examined. Alkaline phosphatase, flotillin, F3 protein and the prion protein were present exclusively in the DIG region of the sucrose gradient over a range of protein/detergent ratios used to solubilize the membranes and displayed a characteristic enrichment in the low-density fraction as the protein/detergent ratio was decreased. In contrast, most of the APP, alkaline phosphodiesterase I, aminopeptidase A and clathrin was effectively solubilized at all of the protein/detergent ratios examined. However, a minor proportion of these latter proteins was detected in DIGs at levels which remained constant irrespective of the protein/detergent ratio. When DIGs were isolated from the sucrose gradients and treated with excess Triton X-100, both the DIG marker proteins and APP, alkaline phosphodiesterase I and clathrin were predominantly resistant to detergent extraction at 37 degrees C. These results show that, although a minor proportion of APP is present in DIGs, where it is detergent-insoluble even at 37 degrees C, it behaves as an atypical lipid raft protein and raises questions as to whether lipid rafts are a site for its proteolytic processing. (+info)Protein tyrosine phosphatase alpha (PTPalpha) and contactin form a novel neuronal receptor complex linked to the intracellular tyrosine kinase fyn. (7/114)
Glycosyl phosphatidylinositol (GPI)-linked receptors and receptor protein tyrosine phosphatases (RPTPs), both play key roles in nervous system development, although the molecular mechanisms are largely unknown. Despite lacking a transmembrane domain, GPI receptors can recruit intracellular src family tyrosine kinases to receptor complexes. Few ligands for the extracellular regions of RPTPs are known, relegating most to the status of orphan receptors. We demonstrate that PTPalpha, an RPTP that dephosphorylates and activates src family kinases, forms a novel membrane-spanning complex with the neuronal GPI-anchored receptor contactin. PTPalpha and contactin associate in a lateral (cis) complex mediated through the extracellular region of PTPalpha. This complex is stable to isolation from brain lysates or transfected cells through immunoprecipitation and to antibody-induced coclustering of PTPalpha and contactin within cells. This is the first demonstration of a receptor PTP in a cis configuration with another cell surface receptor, suggesting an additional mode for regulation of a PTP. The transmembrane and catalytic nature of PTPalpha indicate that it likely forms the transducing element of the complex, and we postulate that the role of contactin is to assemble a phosphorylation-competent system at the cell surface, conferring a dynamic signal transduction capability to the recognition element. (+info)Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression. (8/114)
Axon guidance and target recognition depend on neuronal cell surface receptors that recognize and elicit selective growth cone responses to guidance cues in the environment. Contactin, a cell adhesion/recognition molecule of the immunoglobulin gene superfamily, regulates axon growth and fasciculation in vitro, but its role in vivo is unknown. To assess its function in the developing nervous system, we have ablated contactin gene expression in mice. Contactin-/- mutants displayed a severe ataxic phenotype consistent with defects in the cerebellum and survived only until postnatal day 18. Analysis of the contactin-/- mutant cerebellum revealed defects in granule cell axon guidance and in dendritic projections from granule and Golgi cells. These results demonstrate that contactin controls axonal and dendritic interactions of cerebellar interneurons and contributes to cerebellar microorganization. (+info)
Electron tomography of paranodal septate-like junctions and the associated axonal and glial cytoskeletons in the central...
Characterization of the 5 and promoter regions of the gene encoding the mouse neuronal cell adhesion molecule F3. - PubMed -...
Anand Chandrasekhar | Genetics Area Program
Neurofascin-155 IgM autoantibodies in patients with inflammatory neuropathies | Journal of Neurology, Neurosurgery & Psychiatry
Protein Tyrosine Phosphatase α (Ptpα) and Contactin Form a Novel Neuronal Receptor Complex Linked to the Intracellular Tyrosine...
KAKEN - Research Projects | Role of immunoglobulin superfamily adhesion molecule F3/F11 at the late stage of neural development...
CNTN1 - Contactin-1 precursor - Homo sapiens (Human) - CNTN1 gene & protein
CNTN4 - Contactin-4 precursor - Homo sapiens (Human) - CNTN4 gene & protein
2017-03: A Single-Arm, Open-label Study of Anti-Signaling Lymphocytic Activation Molecule F7 (Anti-SLAMF7) Monoclonal Antibody ...
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Put together mutagenesis of the phosphorylated ... retained
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NRCAM (neuronal cell adhesion molecule)
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Contactin 1, Polyclonal, Invitrogen™ 100μL; Unconjugated Contactin 1, Polyclonal, Invitrogen™
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CNTN2 Gene - GeneCards | CNTN2 Protein | CNTN2 Antibody
CNTN2 Gene - GeneCards | CNTN2 Protein | CNTN2 Antibody
OriGene - CNTN1 (NM 175038) cDNA Clone
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کانتکتین ۱ - ویکیپدیا، دانشنامهٔ آزاد
Disposition of axonal caspr with respect to glial cell membranes: Implications for the process of myelination
MORE Power From Your HGH Supplement Therapy Using 3 Simple Steps
Contactin 5 Antibody (PA5-58814)
Cntnap4 MGI Mouse Gene Detail - MGI:2183572 - contactin associated protein-like 4
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CNTN4: Contactin 4. *COL7A1: Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) ...
Overseas Telecommunications Commission
CONTACT- in-house magazine of OTC. Masterton, R and Prances M; Invisible Bridges, Australia and International ...
کانتکتین ۱ - ویکیپدیا، دانشنامهٔ آزاد
کانتکتین ۱ (انگلیسی: Contactin 1) یک پروتئین است که در انسان توسط ژن «CNTN۱» کُدگذاری میشود. پروتئینی که توسط این ژن ساخته ... Contactin 1. ». در دانشنامهٔ ویکیپدیای انگلیسی، بازبینیشده در ۲۸ آوریل ۲۰۱۸. ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ...
CNTNAP2
Contactin-associated protein-like 2 is a protein that in humans is encoded by the CNTNAP2 gene. Since the most recent reference ... "Entrez Gene: CNTNAP2 contactin associated protein-like 2". Ashley, Euan A. (16 August 2016). "Towards precision medicine". ... Nakabayashi K, Scherer SW (April 2001). "The human contactin-associated protein-like 2 gene (CNTNAP2) spans over 2 Mb of DNA at ... Overview of all the structural information available in the PDB for UniProt: Q9UHC6 (Contactin-associated protein-like 2) at ...
CNTNAP4
Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene. This gene product belongs to ... "Entrez Gene: CNTNAP4 contactin associated protein-like 4". Human CNTNAP4 genome location and CNTNAP4 gene details page in the ...
Node of Ranvier
... such as tenascin R and the cell-adhesion molecules neurofascin and contactin. Contactin is also present at nodes in the CNS and ... At CNS nodes, the axonal proteins also include contactin; however, Schwann cell microvilli are replaced by astrocyte perinodal ...
CNTN1 - Wikipédia, a enciclopédia livre
2001). «Contactin associates with Na+ channels and increases their functional expression.». J. Neurosci. 21 (19): 7517-25. PMID ... 2001). «Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent.». Eur. J. ... Berglund EO, Ranscht B (1994). «Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome ... Berglund EO, Ranscht B (1994). «Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome ...
NFASC
Gollan L, Salomon D, Salzer JL, Peles E (December 2003). "Caspr regulates the processing of contactin and inhibits its binding ... "Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction". Current Biology. 12 ...
Andrew D. Huberman
"Contactin-4 mediates axon-target specificity and functional development of the accessory optic system". Neuron. 86 (4): 985-999 ...
L1 family
... members also bind "heterophilically" to members of the contactin or CNTN1 family. L1 family members bind to many ...
CASPR
"Entrez Gene: Contactin associated protein 1". "OMIM Entry- * 602346 - CONTACTIN-ASSOCIATED PROTEIN 1; CNTNAP1". omim.org. ... "Contactin-Associated Protein (Caspr) and Contactin Form a Complex That Is Targeted to the Paranodal Junctions during ... CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 ... The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino ...
Heritability of autism
Bakkaloglu B, O'Roak BJ, Louvi A et al.. Molecular cytogenetic analysis and resequencing of Contactin Associated Protein-Like 2 ...
Anti-VGKC-complex encephalitis
5 had antibodies against Contactin-2 and 18 (19%) had antibodies with unknown specificity. Of the patients with Contactin-2 ... 2010). "Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin- ... 19 had antibodies reacting with Contactin-associated protein 2 (CASPR 2), ...
Generalized epilepsy with febrile seizures plus
This extracellular region is similar to the cell adhesion molecule contactin and other cell adhesion molecules. It is believed ...
Sulfatide
In order to form a paranodal junction, Caspr and contactin form a complex with neurofascin 155. It has been shown that ... neurofascin 155 protein clusters then bring Caspr and contactin into the membrane to form the complex, which allows the ...
SCN3A
Shah BS, Rush AM, Liu S, Tyrrell L, Black JA, Dib-Hajj SD, Waxman SG (August 2004). "Contactin associates with sodium channel ...
Septate junction
Faivre-Sarrailh C, Banerjee S, Li J, Hortsch M, Laval M, Bhat MA (October 2004). "Drosophila contactin, a homolog of vertebrate ... contactin, is required for septate junction organization and paracellular barrier function". Development. 131 (20): 4931-42. ...
NRCAM
1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine ...
CEE 7 standard AC plugs and sockets
Schuko is an abbreviation for the German word Schutzkontakt, which means "Protective contact" - in this case "protective" ...
Nav1.2
... beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ...
Chronic inflammatory demyelinating polyneuropathy
Autoantibodies to components of the Ranvier nodes, specially autoantibodies the Contactin-associated protein 1 (CASPR), cause a ... contactin-1 and caspr-1. These cases are special not only because of their pathology, but also because they are non-responsive ...
ARFGEF1
Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: ...
Multiple sclerosis research
... contactin 1 (CNTN1), contactin associated protein 1 (CASPR1) and gliomedin. All of them nodal and paranodal proteins. Anti-TNF ...
Notch signaling pathway
... such as F3/contactin. In the nematode C. elegans, two genes encode homologous proteins, glp-1 and lin-12. There has been at ...
Māori religion
... may not be touched by human contact - in some cases, not even approached. A person, object or a place could be made sacred by ...
Clostridium septicum
... as well as the neuronal molecules contactin and Thy-1 (CD90). Quite surprisingly, the alpha toxin of C. septicum is not related ...
Anti-neurofascin demyelinating diseases
The first report about a subgroup of MS patients with anti-NF and contactin 2 auto-antibodies was published in 2011 J. Ciron et ...
LGI1
... glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired ...
CHL1
2009). "Molecular genetic analysis of a cell adhesion molecule with homology to L1CAM, contactin 6, and contactin 4 candidate ...
Tissue stress
The first one is accumulation of TAS effectors in tissue (comutons, chalones, and contactins), which possess a unique feature ... chalones and contactins, which are produced by the cells of a tissue under a stressor's influence. This distinguishes the ...
Contactin - Wikipedia
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the ... The subgroup consists of six members now referred to as contactin 1-6, but historically they had different names as shown in ... the table below: Shimoda, Yasushi; Watanabe, Kazutada (1 January 2009). "Contactins". Cell Adh Migr. 3 (1): 64-70. PMC 2675151 ...
Contactin 3 - Wikipedia
Contactin-3 is a protein that in humans is encoded by the CNTN3 gene. GRCh38: Ensembl release 89: ENSG00000113805 - Ensembl, ... "Entrez Gene: CNTN3 contactin 3 (plasmacytoma associated)". Human CNTN3 genome location and CNTN3 gene details page in the UCSC ... 2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression ...
Contactin-associated protein 1 (IPR028872) | InterPro | EMBL-EBI
In association with contactin, it may have a role in the signaling between axons and myelinating glial cells [PMID: 9118959, ... Contactin-associated protein 1 (also known as paranodin or caspr1) has a key role in the formation of the paranodal junctions ... Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4- ... Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein ...
Cntn5 - Contactin-5 precursor - Rattus norvegicus (Rat) - Cntn5 gene & protein
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity ... Contactin family.Curated. Keywords - Domaini. Immunoglobulin domain, Repeat, Signal. Phylogenomic databases. evolutionary ... IPR032989, Contactin-5. IPR003961, FN3_dom. IPR036116, FN3_sf. IPR007110, Ig-like_dom. IPR036179, Ig-like_dom_sf. ... IPR032989, Contactin-5. IPR003961, FN3_dom. IPR036116, FN3_sf. IPR007110, Ig-like_dom. IPR036179, Ig-like_dom_sf. ...
CNTN6 - Contactin-6 precursor - Homo sapiens (Human) - CNTN6 gene & protein
Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by ... IPR033009. Contactin-6. IPR003961. FN3_dom. IPR036116. FN3_sf. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig ... IPR033009. Contactin-6. IPR003961. FN3_dom. IPR036116. FN3_sf. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig ... Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by ...
Contactin-2/TAG1 Lysates: Novus Biologicals
Browse our Contactin-2/TAG1 Lysate catalog backed by our Guarantee+. ... contactin 2 (axonal) lysate, contactin 2 (transiently expressed) lysate, contactin-2 lysate, DKFZp781D102 lysate, FLJ37193 ... Our Contactin-2/TAG1 Lysates can be used in a variety of model species. Use the list below to choose the Contactin-2/TAG1 ... We offer Contactin-2/TAG1 Lysates for use in common research applications: Western Blot. Each Contactin-2/TAG1 Lysate is fully ...
Contactin-1 Products: R&D Systems
View our 9 Contactin-1 products for your research including Contactin-1 Primary Antibodies, Proteins and Enzymes, cDNA Clones, ... Contactin-2 (TAX-1 in human, TAG1 in rat, and Axonin-1 in chicken), Contactin-4 (BIG-1), Contactin-5 (NB-2), and Contactin-6 ( ... Contactin-1: Products. Contactin-1 (also known as Contactin in human, F3 in rodent, and F11 in chicken), ... NB-3) form the contactin subgroup of cell adhesion molecules within the immunoglobulin superfamily. Contactin-1 and -2 are ...
Plus it
Contactin expression in cultured OPCs 1-4 d after transfection with control and contactin (F3) siRNAs. Note that the contactin ... Contactin is required for L1- and laminin-induced Fyn activation. A, Expression of contactin and Fyn and the level of Fyn ... Contactin expression in oligodendrocytes. A, Western blot for contactin expression in OPCs at the time of plating or after ... B, Survival of OPCs transfected with contactin or control siRNA duplexes and analyzed as in Figure 4. Note that contactin ...
Cntnap4 MGI Mouse Gene Detail - MGI:2183572 - contactin associated protein-like 4
Contactin 5 Antibody (PA5-58814)
Invitrogen Anti-Contactin 5 Polyclonal, Catalog # PA5-58814. Tested in Western Blot (WB), Immunofluorescence (IF), ... Cite Contactin 5 Polyclonal Antibody. The following product was used in this experiment: Contactin 5 Polyclonal Antibody from ... Immunofluorescent staining of Contactin 5 in human cell line U-2 OS shows positivity in cytoplasm. Samples were probed using a ... Immunohistochemical staining of Contactin 5 in human kidney tissue shows strong cytoplasmic positivity in tubular cells. ...
WikiGenes - LOC556251 - contactin-3-like
Contactin 5 - CAGS
While the exact function of CNTN5 is yet to be fully characterized, its paralogs contactin 1 and contactin 2 are known to be ... The CNTN5 gene encodes contactin 5, a member of the immunoglobulin/fibronectin superfamily of adhesion molecules. CNTN5 is a ... glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein and like other contactins, it mediates cell surface ...
Contactin 6 Rabbit anti-Rat, Polyclonal, Invitrogen™
| Fisher Scientific
Immunohistochemistry Shop Contactin 6 Rabbit anti-Rat, Polyclonal, Invitrogen™ ... Contactin 6 Antibody, PA1-18251, from Invitrogen™. Species Reactivity: Rat; Applications: ... The neural adhesion molecule Contactin-6, also known as NB-3, is a contactin/F3 subgroup member of immunoglobulin superfamily. ... Synthetic peptide corresponding to residues K L H K M S S L S S V G V Q I L K P S T Q F of rat contactin-6.. ...
No effect of genetic deletion of contactin-associated protein (CASPR) on axonal orientation and synaptic plasticity. - PubMed ...
No effect of genetic deletion of contactin-associated protein (CASPR) on axonal orientation and synaptic plasticity.. Pillai AM ... No Effect of Genetic Deletion of Contactin-Associated Protein (CASPR) on Axonal Orientation and Synaptic Plasticity ... No Effect of Genetic Deletion of Contactin-Associated Protein (CASPR) on Axonal Orientation and Synaptic Plasticity ... No Effect of Genetic Deletion of Contactin-Associated Protein (CASPR) on Axonal Orientation and Synaptic Plasticity ...
Interaction of amyloid precursor protein with contactins and NgCAM in the retinotectal system | Development
KDs: contactin 4-APP, 17 nM; contactin 4-APLP1, 28 nM; contactin 3-APP, 22 nM; contactin 3-APLP1, 35 nM; and contactin 5-APLP1 ... Our studies show that APP binds both contactin 3 and 4. APLP1 was found to bind contactins 3 and 4, and also contactin 5. These ... On contactin 4, the APP-binding site localizes to the FN-like domains, which could leave the Ig domains of contactin free to ... APP and APLP1 bind to specific contactin family members. (A) AP fusion proteins were tested for binding to contactin-Fc fusion ...
Contactin-associated protein-2 antibodies in non-paraneoplastic cerebellar ataxia | Journal of Neurology, Neurosurgery &...
A 180-kDa polyprotein was selectively precipitated by the patient serum (figure 1C) and identified as contactin-associated ... Here we have identified a potentially pathogenic antibody against the neuronal membrane protein contactin-associated protein 2 ... Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated ... which resulted in the identification of contactin-associated protein 2 (CASPR2) as a major antigen. CASPR2 antibodies were then ...
Human Contactin 2 (Axonal) (CNTN2) Protein (His tag), Recombinant | ABIN3209897
Recombinant Contactin 2 (Axonal) (CNTN2) Protein (His tag). Species: Human. Source: Escherichia coli (E. coli). Order product ... Contactin 2 (Axonal) (CNTN2) (AA 877-1040) protein (His tag) Protein CNTN2 Origin: Human Source: Escherichia coli (E. coli) ... Contactin 2 (Axonal) (CNTN2) (AA 802-1008) protein (T7 tag,His tag) Protein ...
No Evidence for Association of Autism with Rare Heterozygous Point Mutations in Contactin-Associated Protein-Like 2 (CNTNAP2),...
Destruction of paranodal architecture in inflammatory neuropathy with anti-contactin-1 autoantibodies | Journal of Neurology,...
Anti-contactin-1-associated neuropathy does not meet morphological criteria of demyelinating neuropathy and therefore, might ... Methods We used ELISA to detect autoantibodies against contactin-1. Specificity of the autoantibodies was confirmed by ... Results High reactivity to contactin-1 by ELISA was found in four patients with chronic inflammatory demyelinating ... Interpretation We conclude that anti-contactin-1-related neuropathy constitutes a presumably autoantibody-mediated form of ...
Recombinant Human Contactin-4 or CNTN4 Protein.
... is an axonal cell adhesion molecule that belongs to the contactin family. This protein has the ability to promote neurite ... Contactin family proteins exist as membranebound proteins, but can also be released as soluble proteins by GPIspecific ... Rat hippocampal neurons grown on microplates pre-coated with human Contactin-4 ... Rat hippocampal neurons grown on microplates pre-coated with human Contactin-4 ...
CNTN1 / gp135 / Contactin 1 Antibody (N-Terminal) for ELISA, WB/Western
Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse ... Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse ... Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse ... CNTN1 / gp135 / Contactin 1 Antibody (aa81‑130, FITC) LS‑C466250 Species: Human, Chimpanzee, Orangutan, Gibbon, Monkey, Rat, ...
CNTN1 / gp135 / Contactin 1 Antibody (aa736-1003, PE) for IHC, WB/Western
Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). Validated ... Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). Validated ... Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). Validated ... CNTN1 / gp135 / Contactin 1 Antibody (aa81‑130, FITC) LS‑C466250 Species: Human, Chimpanzee, Orangutan, Gibbon, Monkey, Rat, ...
Contactin 6 / NB-3 (mouse aa160-172) Antibody (internal region) - Peptide-affinity purified goat antibody E - Buy Now! |Abgent
Contactin 6 / NB-3 (mouse aa160-172) Antibody (internal region), Peptide-affinity purified goat antibody validated in E ( ... Contactin-6, Neural recognition molecule NB-3, hNB-3, CNTN6. Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with ... Contactin 6 / NB-3 (mouse aa160-172) Antibody (internal region) is for research use only and not for use in diagnostic or ... home , Products , Primary Antibodies , Antibody Collections , Goat Antibodies , Contactin 6 / NB-3 (mouse aa160-172) Antibody ( ...
Contactin 4 / Big-2 (mouse aa160-172) Antibody (internal region) - Peptide-affinity purified goat antibody WB, E - Buy Now! ...
Contactin 4 / Big-2 (mouse aa160-172) Antibody (internal region), Peptide-affinity purified goat antibody validated in WB, E ( ... Contactin-4, Brain-derived immunoglobulin superfamily protein 2, BIG-2, CNTN4. Format 0.5 mg/ml in Tris saline, 0.02% sodium ... Contactin 4 / Big-2 (mouse aa160-172) Antibody (internal region) is for research use only and not for use in diagnostic or ... home , Products , Primary Antibodies , Antibody Collections , Goat Antibodies , Contactin 4 / Big-2 (mouse aa160-172) Antibody ...
Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA - RC214706 - 10 µg...
Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA - 10 µg - OriGene ... home , products , origene , myc-ddk-tagged orf clone of homo sapiens contactin 1 (cntn1), transcript variant 1 as transfection- ... Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA - RC214706 - 10 µg ... TrueORF Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA ...
The contactin-related protein FAR-2 defines purkinje cell clusters and labels subpopulations of climbing fibers in the...
Plagge, A; Sendtner-Voelderndorff, L; Sirim, P; Freigang, J; Rader, C; Sonderegger, P; Brümmendorf, T (2001). The contactin- ... FAR-2 is a novel neural member of the Ig superfamily, which is related to F11/F3/contactin and axonin-1/TAG-1. This protein is ... FAR-2 is a novel neural member of the Ig superfamily, which is related to F11/F3/contactin and axonin-1/TAG-1. This protein is ... The contactin-related protein FAR-2 defines purkinje cell clusters and labels subpopulations of climbing fibers in the ...
Disruption of contactin 4 in three subjects with autism spectrum disorder - Semantic Scholar
... sequence analysis revealed the variations to have resulted from Alu Y mediated unequal recombinations interrupting contactin 4 ... Contactin-1/F3 Regulates Neuronal Migration and Morphogenesis Through Modulating RhoA Activity. Taiping Chen, I Lu, J Tsai ... Disruption of Contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome.. Thomas Fernandez ... Morphophysiological effects of insertional mutagenesis of the contactin 5 (Cntn5) gene in transgenic mice. Alexander V Smirnov ...
Protein Tyrosine Phosphatase α (Ptpα) and Contactin Form a Novel Neuronal Receptor Complex Linked to the Intracellular Tyrosine...
... myr-PTPα/contactin (myr-α/cont), or PTPα/contactin (α/cont) were probed for PTPα and contactin. (B) Whole cell lysates (WCL) ... myr-PTPα/contactin (myr-α/cont), or PTPα/contactin (α/cont) were probed for PTPα and contactin. (B) Whole cell lysates (WCL) ... Coclusters of contactin and PTPα could also be induced by 4D1 mAb specific for contactin ( Fig. 3C and Fig. D). Clusters of ... PTPα and Contactin Are Associated in Chick Brain. Contactin and PTPα immunoprecipitates from embryonic chick brain lysates were ...
"Quantitative Analysis of Contactin-Associated Protein and Voltage-Gate" by Daniel Gardiner
Frontiers | Latrophilins: A Neuro-Centric View of an Evolutionary Conserved Adhesion G Protein-Coupled Receptor Subfamily |...
Out of the six isoforms of contactins found in vertebrates (contactin-1,-2,-3,-4,-5, and -6), only contactin-6 was identified ... Contactins. As part of the immunoglobulin cell adhesion molecules, contactins extracellular region consists of immunoglobulin- ... Although contactins lack a transmembrane domain, they are linked to the cell surface via a GPI anchor, a feature that allows ... Contactins have been shown to form molecular complexes with various transmembrane proteins therefore allowing them to provide a ...
ProteinCNTN1ProteinsAntibodyCNTN4ImmunoglobulinGlycoproteinNeuralAdhesionSubgroup consists of six membersSuperfamilyELISASpecificityLigand2001CasprGenesNeuronsCerebrospinal fluidDifferentially expressedReceptorPrecursorSynapticNeurite outgrowthExtracellular matrixTAG1ImmunogenKnockdownHumanCellAmyloidPTPRGParanodalMice
Protein36
- Contactin-3 is a protein that in humans is encoded by the CNTN3 gene. (wikipedia.org)
- Contactin-associated protein 1 (also known as paranodin or caspr1) has a key role in the formation of the paranodal junctions and is required for normal saltatory conduction [ PMID: 11395000 ]. (ebi.ac.uk)
- Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. (ebi.ac.uk)
- Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors. (ebi.ac.uk)
- The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. (thermofisher.com)
- CNTN5 is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein and like other contactins, it mediates cell surface interactions during nervous system development. (cags.org.ae)
- No effect of genetic deletion of contactin-associated protein (CASPR) on axonal orientation and synaptic plasticity. (nih.gov)
- In vitro binding studies revealed direct interactions among multiple members of the APP and contactin protein families. (biologists.org)
- One strong-binding serum was selected for immunoprecipitation and mass spectrometry, which resulted in the identification of contactin-associated protein 2 (CASPR2) as a major antigen. (bmj.com)
- Here we have identified a potentially pathogenic antibody against the neuronal membrane protein contactin-associated protein 2 (CASPR2) in nine of 88 (10%) patients with unexplained ataxia. (bmj.com)
- Recombinant Human Contactin-4 or CNTN4 Protein. (neuromics.com)
- Contactin 1 Polyclonal Antibody detects endogenous levels of Contactin 1 protein. (lsbio.com)
- The contactin-related protein FAR-2 defines purkinje cell clusters and labels subpopulations of climbing fibers in the developing cerebellum. (uzh.ch)
- Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. (semanticscholar.org)
- There are 5 Contactin 3 protein produced in house with high quality which are covering various species. (sinobiological.com)
- Among these Contactin 3 proteins, there are 2 Human Contactin 3 protein, 1 Mouse Contactin 3 protein, 2 Rat Contactin 3 protein. (sinobiological.com)
- All these Contactin 3 protein are expressed by different host cells. (sinobiological.com)
- CNTN2 (Contactin 2) is a Protein Coding gene. (genecards.org)
- CNTN6 (Contactin 6) is a Protein Coding gene. (genecards.org)
- Recombinant Contactin 3 Protein, Rat (Fc Tag) Recombinant Proteins The rat CNTN3 (Met1-Gly1001) was expressed with the Fc region of human IgG1 at the C-terminus The recombinant rat CNTN3/Fc is a disulfide-linked homodimer. (thebiotek.com)
- Contactin-associated protein 4 (Caspr4), also known as contactin-associated protein-like protein (CNTNAP4), is normally portrayed in several regions of the brain. (angiogenesis-blog.com)
- Contactin-associated proteins 4 (Caspr4), also known as contactin-associated protein-like proteins (CNTNAP4), is normally a transmembrane proteins member of the neurexin superfamily included in neuronCglia connections and the clustering of T+ stations in myelinated axons [13C17]. (angiogenesis-blog.com)
- Protein-tyrosine phosphatase receptor type G (RPTPγ/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system. (rcsb.org)
- We studied the molecular sites of interaction between human contactin 4, -5 or -6 and the human Protein Tyrosine Phosphatase Receptor Gamma (PTPRG), a contactin partner, by modeling their 3D structures. (pasteur.fr)
- Association of Leucine-Rich Glioma Inactivated Protein 1, Contactin-Associated Protein 2, and Contactin 2 Antibodies With Clinical Features and Patient-Reported Pain in Acquired Neuromyotonia. (ox.ac.uk)
- Importance: Although acquired autoimmune neuromyotonia (NMT) is associated with voltage-gated potassium channel (VGKC)-complex antibodies, to date there has been no systematic study of autoantibodies to the specific antigens leucine-rich glioma inactivated protein 1 (LGI1), contactin-associated protein 2 (CASPR2), and contactin 2 together with the full clinical syndrome, particularly pain and autonomic and central nervous system involvement. (ox.ac.uk)
- We use a single molecule atomic force spectroscopy combined with the steered molecular dynamics simulation to determine a mechanical behavior of neural cell adhesion protein contactin during its unfolding. (edu.pl)
- METHODS: Antibodies to neurofascin-155 (Nfasc155), neurofascin-140/186 (Nfasc140/186), contactin-1 (CNTN1), and contactin-associated protein 1 (Caspr1) were detected with ELISA and/or cell-based assay. (elsevier.com)
- Contactin-2 is a synaptic and axonal membrane protein that interacts with proteins involved in the pathology of AD such as amyloid precursor protein (APP) and beta-secretase 1 (BACE1). (biomedcentral.com)
- We developed a FCS set-up for contactin-2, a neuronal cell adhesion molecule and a ligand of beta-secretase 1 (BACE1) and amyloid precursor protein (APP), the latter proteins being important players in AD. (vumc.nl)
- Using mouse models, the researchers demonstrate that image stabilization depends upon two proteins, Contactin-4 and amyloid precursor protein, binding during embryonic development. (eurekalert.org)
- On the other hand, when they added Contactin-4 to a cell that doesn't normally produce it, that one additional protein was all the cell needed make the circuits for a steady eye-brain connection. (eurekalert.org)
- If amyloid precursor protein isn't available, the researchers discovered, Contactin-4 can't control development of the visual circuitry. (eurekalert.org)
- Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. (nature.com)
- In sciatic nerve, the expression of contactin, receptor protein tyrosine phosphatase β, and the Na + -channel β 1 subunit, paranodal caspr and nodal ankyrin G was unaltered in 2-month type 1 diabetic BB/Wor rats but significantly decreased after 8 months of diabetes. (diabetesjournals.org)
- Shows that the stabilization of the Caspr/contactin complex at the cell membrane requires the intracellular region, which includes the protein 4.1B-binding domain). (scorcher.ru)
CNTN13
- The contactin family comprises six members (CNTN1/F3, CNTN2/TAG1, CNTN3/BIG1, CNTN4/BIG2, CNTN5/NB2 and CNTN6/NB3) and are characterized by the presence of six Ig like domains, four fibronectin type III like repeats, and a glycosylphosphatidylinositol (GPI) anchoring domain. (neuromics.com)
- Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse and rat. (lsbio.com)
- Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). (lsbio.com)
Proteins7
- Co-precipitation from these tissues and tandem mass spectrometry led to the identification of two associated proteins: contactin 4 and NgCAM. (biologists.org)
- Functional assays revealed regulatory effects of both APP and contactin 4 on NgCAM-dependent growth of cultured retinal axons, demonstrating specific functional interactions among these proteins. (biologists.org)
- These studies identify novel binding and functional interactions among proteins of the APP, contactin and L1CAM families, with general implications for mechanisms of APP action in neural development and disease. (biologists.org)
- Contactin family proteins exist as membranebound proteins, but can also be released as soluble proteins by GPIspecific phospholipase D. Soluble Contactins are functionsl proteins that are able to promote neurite outgrowth. (neuromics.com)
- These Contactin 3 proteins are produced with different tags, such as His Tag, Fc Tag. (sinobiological.com)
- This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. (nih.gov)
- Then the team went looking for proteins that bind Contactin-4. (eurekalert.org)
Antibody3
- The following product was used in this experiment: Contactin 5 Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-58814, RRID AB_2640053. (thermofisher.com)
- This complex is stable to isolation from brain lysates or transfected cells through immunoprecipitation and to antibody-induced coclustering of PTPα and contactin within cells. (rupress.org)
- Main Outcomes and Measures: Clinical data and scores on the modified Rankin Scale (mRS), which measures disability on a range of 0 to 6, with 0 indicating normal and 6 indicating death, before and after treatments were combined with CASPR2, LGI1, and contactin 2 antibody status. (ox.ac.uk)
CNTN42
- Contactin4 (CNTN4), also known as BIG2 (Brainderived Immunoglobulin Superfamily molecule 2), is an axonal cell adhesion molecule that belongs to the contactin family, a subfamily of the Ig superfamily (1 3). (neuromics.com)
- Disruption of Contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome. (semanticscholar.org)
Immunoglobulin6
- Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. (wikipedia.org)
- C ontactin-1 (also known as Contactin in human, F3 in rodent, and F11 in chicken), Contactin-2 (TAX-1 in human, TAG1 in rat, and Axonin-1 in chicken), Contactin-4 (BIG-1), Contactin-5 (NB-2), and Contactin-6 (NB-3) form the contactin subgroup of cell adhesion molecules within the immunoglobulin superfamily. (rndsystems.com)
- The CNTN5 gene encodes contactin 5, a member of the immunoglobulin/fibronectin superfamily of adhesion molecules. (cags.org.ae)
- The neural adhesion molecule Contactin-6, also known as NB-3, is a contactin/F3 subgroup member of immunoglobulin superfamily. (fishersci.ca)
- Contactin-3 contains 4 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. (thebiotek.com)
- Contactins (Cntns) are a six-member subgroup of the immunoglobulin cell adhesion molecule superfamily (IgCAMs) with pronounced brain expression and function. (uu.nl)
Glycoprotein5
- Contactin-3, also known as CNTN3 ( BIG-1 in rat and PANG in mouse ), is a GPI-linked glycoprotein that is expressed on cerebellar Purkinje cells, amygdaloid and thalamic neurons and olfactory granule cells. (thebiotek.com)
- 2001). «Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent. (wikipedia.org)
- Transgenic mice expressing F3/contactin from the Transient Axonal Glycoprotein promoter undergo developmentally regulated deficits of the cerebellar function. (uniroma1.it)
- We have shown that transgenic transient axonal glycoprotein (TAG)/F3 mice, in which the mouse axonal glycoprotein F3/contactin was misexpressed from a regulatory region of the gene encoding the transient axonal glycoprotein TAG-1, exhibit a transient disruption of cerebellar granule and Purkinje cell development [Development 130 (2003) 29]. (uniroma1.it)
- Contactin, a glycosyl-phosphatidylinositol (GPI)-anchored predominantly neuronal cell surface glycoprotein, associates with sodium channels Nav1.2, Nav1.3 and Nav1.9, and enhances the density of these channels on the plasma membrane in mammalian expression systems. (qxmd.com)
Neural3
- While the exact function of CNTN5 is yet to be fully characterized, its paralogs contactin 1 and contactin 2 are known to be involved in neural cell migration, axon guidance and myelin subdomain organization. (cags.org.ae)
- FAR-2 is a novel neural member of the Ig superfamily, which is related to F11/F3/contactin and axonin-1/TAG-1. (uzh.ch)
- The neural cell-adhesion molecules contactin 4, contactin 5 and contactin 6 are involved in brain development, and disruptions in contactin genes may confer increased risk for autism spectrum disorders (ASD). (pasteur.fr)
Adhesion2
- Identification and characterization of the human cell adhesion molecule contactin. (wikipedia.org)
- From this, the team found Contactin-4, an adhesion molecule. (eurekalert.org)
Subgroup consists of six members1
- The subgroup consists of six members: Contactin-1, Contactin-2(TAG-1), Contactin-3(BIG-1), BIG-2, Contactin-5(NB-2) and NB-3. (thebiotek.com)
Superfamily1
- We first demonstrate that the Ig superfamily molecule contactin is associated in oligodendrocytes with integrins, extracellular matrix receptors that regulate target-dependent survival by amplification of growth factor signaling. (jneurosci.org)
ELISA2
- Methods We used ELISA to detect autoantibodies against contactin-1. (bmj.com)
- Results High reactivity to contactin-1 by ELISA was found in four patients with chronic inflammatory demyelinating polyradiculoneuropathy and in none of the patients with Guillain-Barré syndrome, which was confirmed by cell binding assays in all four patients. (bmj.com)
Specificity1
- Specificity of the autoantibodies was confirmed by immunoblot assay, binding to contactin-1-transfected human embryonic kidney cells, binding to paranodes of murine teased fibres and preabsorption experiments. (bmj.com)
Ligand3
- In contrast, the presence of L1-Fc, the extracellular portion of a contactin ligand expressed on axons, enhanced survival and additionally promoted myelination in cocultures of neurons and oligodendrocytes. (jneurosci.org)
- 1995). «The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin. (wikipedia.org)
- Contactin is a noncanonical Notch receptor ligand that mediates oligodendrocyte differentiation. (jci.org)
20011
- 2001). «Contactin associates with Na+ channels and increases their functional expression. (wikipedia.org)
Caspr1
- Biochemical characterizations of the paranodal axoglial SJs have identified several molecular components that include Caspr and contactin (Cont) on the axonal side and neurofascin 155 kDa (NF155) isoform on the glial side. (nih.gov)
Genes1
- For example, since the Contactin-4 gene is located in a cluster of genes that have been implicated in some forms of autism, they want to know if aberrations in that particular gene might play a role in development of the disease. (eurekalert.org)
Neurons3
- Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. (thebiotek.com)
- We describe a co-culture of rat cortical neurons and HEK293 cells overexpressing and delivering the secreted forms of rat contactin 4-6. (pasteur.fr)
- We examined the expression and function of sodium channels in small-diameter dorsal root ganglion (DRG) neurons from contactin-deficient (CNTN-/-) mice, compared to CNTN+/+ litter mates. (qxmd.com)
Cerebrospinal fluid1
- We hypothesized that AD might be characterized by changes in contactin-2 levels in the cerebrospinal fluid (CSF) and brain tissue. (biomedcentral.com)
Differentially expressed1
- Contactin-1 and -2 are differentially expressed in a number of neuronal tissues during development and interact with several ligands including Nr-CAM, L1, NCAM, neurocan, phosphacan, and tenascin. (rndsystems.com)
Receptor2
- We demonstrate that PTPα, an RPTP that dephosphorylates and activates src family kinases, forms a novel membrane-spanning complex with the neuronal GPI-anchored receptor contactin. (rupress.org)
- 1997). «Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta.» . (wikipedia.org)
Precursor1
- show that Contactin is abundantly expressed on demyelinated axons in human chronic MS lesions and that Notch1 is activated in oligodendrocyte precursor cells (see the related article beginning on page 169). (jci.org)
Synaptic1
- Taken together, these data reveal that the contactin-2 changes observed in tissues are reflected in CSF, suggesting that decreased contactin-2 CSF levels might be a biomarker reflecting synaptic or axonal loss. (biomedcentral.com)
Neurite outgrowth1
- Contactin-3 may mediate cell-cell interaction and may promote neurite outgrowth. (thebiotek.com)
Extracellular matrix2
- We conclude, therefore, that a novel integrin/contactin complex coordinates signals from extracellular matrix and the axonal surface to regulate both oligodendrocyte survival and myelination by controlling Fyn activity. (jneurosci.org)
- Immunohistochemical analysis revealed that contactin-2 is expressed in the extracellular matrix. (biomedcentral.com)
TAG14
- We offer Contactin-2/TAG1 Lysates for use in common research applications: Western Blot. (novusbio.com)
- Each Contactin-2/TAG1 Lysate is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
- Our Contactin-2/TAG1 Lysates can be used in a variety of model species. (novusbio.com)
- Choose from our Contactin-2/TAG1 Lysates. (novusbio.com)
Immunogen1
- The PA1-18251 immunogen is a synthetic peptide corresponding to residues K L H K M S S L S S V G V Q I L K P S T Q F of rat contactin-6, conjugated to KLH. (fishersci.ca)
Knockdown2
- This amplification is inhibited by small interfering RNA-mediated knockdown of contactin in oligodendrocytes. (jneurosci.org)
- Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma. (nature.com)
Human4
- Synthesized peptide derived from human Contactin 1. (lsbio.com)
- Human Contactin-3 shares 92% aa identity with mouse Contactin-3.The exact function of Contactin-3 is unclear. (thebiotek.com)
- However, interactive residues between human contactin 4-6 and PTPRG were strictly conserved. (pasteur.fr)
- We further characterized the expression of contactin-2 in postmortem AD human brain ( n = 14) versus nondemented controls ( n = 9). (biomedcentral.com)
Cell3
- Contactins mediate cell surface interactions during nervous system development. (uniprot.org)
- The transmembrane and catalytic nature of PTPα indicate that it likely forms the transducing element of the complex, and we postulate that the role of contactin is to assemble a phosphorylation-competent system at the cell surface, conferring a dynamic signal transduction capability to the recognition element. (rupress.org)
- This mode of membrane attachment precludes direct transfer of signals into the cell, but allows high mobility in the plane of the membrane, and as such ideally suits contactin for responding to macromolecular stimuli presented to the cell ( Vaughan 1996 ). (rupress.org)
Amyloid1
- Lower levels of contactin-2 were specifically found in and around amyloid plaques in AD hippocampus and temporal cortex. (biomedcentral.com)
PTPRG1
- We did not observe any differences in PTPRG binding on contactin 5 and -6 either. (pasteur.fr)
Paranodal2
- We describe the clinical phenotype and histopathological changes of paranodal architecture of patients with autoantibodies against contactin-1, identified from a cohort with chronic inflammatory demyelinating polyradiculoneuropathy (n=53) and Guillain-Barré syndrome (n=21). (bmj.com)
- Interpretation We conclude that anti-contactin-1-related neuropathy constitutes a presumably autoantibody-mediated form of inflammatory neuropathy with distinct clinical symptoms and disruption of paranodal architecture as a pathological correlate. (bmj.com)
Mice1
- 2000). «Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression. (wikipedia.org)