Analysis of receptor binding by the channel-forming toxin aerolysin using surface plasmon resonance. (1/114)Aerolysin is a channel-forming bacterial toxin that binds to glycosylphosphatidylinositol (GPI) anchors on host cell-surface structures. The nature of the receptors and the location of the receptor-binding sites on the toxin molecule were investigated using surface plasmon resonance. Aerolysin bound to the GPI-anchored proteins Thy-1, variant surface glycoprotein, and contactin with similar rate constants and affinities. Enzymatic removal of N-linked sugars from Thy-1 did not affect toxin binding, indicating that these sugars are not involved in the high affinity interaction with aerolysin. Aerolysin is a bilobal protein, and both lobes were shown to be required for optimal binding. The large lobe by itself bound Thy-1 with an affinity that was at least 10-fold weaker than that of the whole toxin, whereas the small lobe bound the GPI-anchored protein at least 1000-fold more weakly than the intact toxin. Mutation analyses provided further evidence that both lobes were involved in GPI anchor binding, with certain single amino acid substitutions in either domain leading to reductions in affinity of as much as 100-fold. A variant with single amino acid substitutions in both lobes of the protein was completely unable to bind the receptor. The membrane protein glycophorin, which is heavily glycosylated but not GPI-anchored, bound weakly to immobilized proaerolysin, suggesting that interactions with cell-surface carbohydrate structures other than GPI anchors may partially mediate toxin binding to host cells. (+info)
Functional interactions of the immunoglobulin superfamily member F11 are differentially regulated by the extracellular matrix proteins tenascin-R and tenascin-C. (2/114)The axon-associated protein F11 is a GPI-anchored member of the immunoglobulin superfamily that promotes axon outgrowth and that shows a complex binding pattern toward multiple cell surface and extracellular matrix proteins including tenascin-R and tenascin-C. In this study, we demonstrate that tenascin-R and tenascin-C differentially modulate cell adhesion and neurite outgrowth of tectal cells on F11. While soluble tenascin-R increases the number of attached cells and the percentage of cells with neurites on immobilized F11, tenascin-C stimulates cell attachment to a similar extent but decreases neurite outgrowth. The cellular receptor interacting with F11 has been previously identified as NrCAM; however, in the presence of tenascin-R or tenascin-C cell attachment and neurite extension are independent of NrCAM. Antibody perturbation experiments indicate that beta(1) integrins instead of NrCAM function as receptor for neurite outgrowth of tectal cells on an F11.TN-R complex. Cellular binding assays support the possibility that the interaction of F11 to NrCAM is blocked in the presence of tenascin-R and tenascin-C. Furthermore, a sandwich binding assay demonstrates that tenascin-R and tenascin-C are able to form larger molecular complexes and to link F11 polypeptides by forming a molecular bridge. These results suggest that the molecular interactions of F11 might be regulated by the presence of tenascin-R and tenascin-C. (+info)
NrCAM, cerebellar granule cell receptor for the neuronal adhesion molecule F3, displays an actin-dependent mobility in growth cones. (3/114)The neuronal adhesion glycoprotein F3 is a multifunctional molecule of the immunoglobulin superfamily that displays heterophilic binding activities. In the present study, NrCAM was identified as the functional receptor mediating the inhibitory effect of F3 on axonal elongation from cerebellar granule cells. F3Fc-conjugated microspheres binding to neuronal growth cones resulted from heterophilic interaction with NrCAM but not with L1. Time-lapse video-microscopy indicated that F3Fc beads bind at the leading edge and move retrogradely to reach the base of the growth cone within a lapse of 30-60 seconds. Such velocity (5.7 microm/minute) is consistent with a coupling between F3 receptors and the retrograde flow of actin filaments. When actin filaments were disrupted by cytochalasin B, the F3Fc beads remained immobile at the leading edge. The retrograde mobility appeared to be dependent on NrCAM clustering since it was induced upon binding with cross-linked but not dimeric F3Fc chimera. These data indicate that F3 may control growth cone motility by modulating the linkage of its receptor, NrCAM, to the cytoskeleton. They provide further insights into the mechanisms by which GPI-anchored adhesion molecules may exert an inhibitory effect on axonal elongation. (+info)
Pathological missense mutations of neural cell adhesion molecule L1 affect homophilic and heterophilic binding activities. (4/114)Mutations in the gene for neural cell adhesion molecule L1 (L1CAM) result in a debilitating X-linked congenital disorder of brain development. At the neuronal cell surface L1 may interact with a variety of different molecules including itself and two other CAMs of the immunoglobulin superfamily, axonin-1 and F11. However, whether all of these interactions are relevant to normal or abnormal development has not been determined. Over one-third of patient mutations are single amino acid changes distributed across 10 extracellular L1 domains. We have studied the effects of 12 missense mutations on binding to L1, axonin-1 and F11 and shown for the first time that whereas many mutations affect all three interactions, others affect homophilic or heterophilic binding alone. Patient pathology is therefore due to different types of L1 malfunction. The nature and functional consequence of mutation is also reflected in the severity of the resultant phenotype with structural mutations likely to affect more than one binding activity and result in early mortality. Moreover, the data indicate that several extracellular domains of L1 are required for homophilic and heterophilic interactions. (+info)
Compartmentation of Fyn kinase with glycosylphosphatidylinositol-anchored molecules in oligodendrocytes facilitates kinase activation during myelination. (5/114)In many cell types, glycosylphosphatidylinositol (GPI)-anchored proteins are sequestered in detergent-resistant membrane rafts. These are plasma membrane microdomains enriched in glycosphingolipids and cholesterol and are suggested to be platforms for cell signaling. Concomitant with the synthesis of myelin glycosphingolipids, maturing oligodendrocytes progressively associate GPI-anchored proteins, including the adhesion molecules NCAM 120 and F3, in rafts. Here we show that these microdomains include Fyn and Lyn kinases. Both kinases are maximally active in myelin prepared from young animals, correlating with early stages of myelination. In the rafts, Fyn kinase is tightly associated with NCAM 120 and F3. In contrast, in oligodendrocyte progenitor cells lacking rafts or in raft-free membrane domains of more mature cells, F3 does not associate with Fyn. The addition of anti-F3 antibodies to oligodendrocytes results in stimulation of Fyn kinase specifically in rafts. Compartmentation of oligodendrocyte GPI-anchored proteins in rafts is thus a prerequisite for association with Fyn, permitting kinase activation. Interaction of oligodendrocyte F3 with axonal ligands such as L1 and ensuing kinase activation may play a crucial role in initiating myelination. (+info)
Amyloid precursor protein, although partially detergent-insoluble in mouse cerebral cortex, behaves as an atypical lipid raft protein. (6/114)Lipid rafts are regions of the plasma membrane that are enriched in cholesterol, glycosphingolipids and acylated proteins, and which have been proposed as sites for the proteolytic processing of the Alzheimer's amyloid precursor protein (APP). Lipid rafts can be isolated on the basis of their insolubility in Triton X-100 at 4 degrees C, with the resulting low-density, detergent-insoluble glycolipid-enriched fraction (DIG) being isolated by flotation through a sucrose density gradient. The detergent-insolubility of APP in mouse cerebral cortex relative to a variety of DIG marker proteins (alkaline phosphatase, flotillin, F3 protein and prion protein) and non-DIG proteins (alkaline phosphodiesterase I, aminopeptidase A and clathrin) has been examined. Alkaline phosphatase, flotillin, F3 protein and the prion protein were present exclusively in the DIG region of the sucrose gradient over a range of protein/detergent ratios used to solubilize the membranes and displayed a characteristic enrichment in the low-density fraction as the protein/detergent ratio was decreased. In contrast, most of the APP, alkaline phosphodiesterase I, aminopeptidase A and clathrin was effectively solubilized at all of the protein/detergent ratios examined. However, a minor proportion of these latter proteins was detected in DIGs at levels which remained constant irrespective of the protein/detergent ratio. When DIGs were isolated from the sucrose gradients and treated with excess Triton X-100, both the DIG marker proteins and APP, alkaline phosphodiesterase I and clathrin were predominantly resistant to detergent extraction at 37 degrees C. These results show that, although a minor proportion of APP is present in DIGs, where it is detergent-insoluble even at 37 degrees C, it behaves as an atypical lipid raft protein and raises questions as to whether lipid rafts are a site for its proteolytic processing. (+info)
Protein tyrosine phosphatase alpha (PTPalpha) and contactin form a novel neuronal receptor complex linked to the intracellular tyrosine kinase fyn. (7/114)Glycosyl phosphatidylinositol (GPI)-linked receptors and receptor protein tyrosine phosphatases (RPTPs), both play key roles in nervous system development, although the molecular mechanisms are largely unknown. Despite lacking a transmembrane domain, GPI receptors can recruit intracellular src family tyrosine kinases to receptor complexes. Few ligands for the extracellular regions of RPTPs are known, relegating most to the status of orphan receptors. We demonstrate that PTPalpha, an RPTP that dephosphorylates and activates src family kinases, forms a novel membrane-spanning complex with the neuronal GPI-anchored receptor contactin. PTPalpha and contactin associate in a lateral (cis) complex mediated through the extracellular region of PTPalpha. This complex is stable to isolation from brain lysates or transfected cells through immunoprecipitation and to antibody-induced coclustering of PTPalpha and contactin within cells. This is the first demonstration of a receptor PTP in a cis configuration with another cell surface receptor, suggesting an additional mode for regulation of a PTP. The transmembrane and catalytic nature of PTPalpha indicate that it likely forms the transducing element of the complex, and we postulate that the role of contactin is to assemble a phosphorylation-competent system at the cell surface, conferring a dynamic signal transduction capability to the recognition element. (+info)
Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression. (8/114)Axon guidance and target recognition depend on neuronal cell surface receptors that recognize and elicit selective growth cone responses to guidance cues in the environment. Contactin, a cell adhesion/recognition molecule of the immunoglobulin gene superfamily, regulates axon growth and fasciculation in vitro, but its role in vivo is unknown. To assess its function in the developing nervous system, we have ablated contactin gene expression in mice. Contactin-/- mutants displayed a severe ataxic phenotype consistent with defects in the cerebellum and survived only until postnatal day 18. Analysis of the contactin-/- mutant cerebellum revealed defects in granule cell axon guidance and in dendritic projections from granule and Golgi cells. These results demonstrate that contactin controls axonal and dendritic interactions of cerebellar interneurons and contributes to cerebellar microorganization. (+info)
Electron tomography of paranodal septate-like junctions and the associated axonal and glial cytoskeletons in the central...
The polarized domains of myelinated axons are specifically organized to maximize the efficiency of saltatory conduction. The paranodal region is directly adjacent to the node of Ranvier and contains specialized septate-like junctions that provide adhesion between axons and glial cells and that const …
Characterization of the 5 and promoter regions of the gene encoding the mouse neuronal cell adhesion molecule F3. - PubMed -...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Anand Chandrasekhar | Genetics Area Program
Gurung, S., Asante, E., Hummel, D., Williams, A., Feldman-Schultz, O., Halloran, M., Sittaramane, V. and Chandrasekhar, A., (2018) Distinct roles for the cell adhesion molecule Contactin2 in the development and function of neural circuits in zebrafish. Mechanisms of Development : 152: 1-12.. Kassim, Y. M., Al-Shakarji, N. M., Asante, E., Chandrasekhar, A. and Palaniappan, K., (2018) Dissecting branchiomotor neuron circuits in zebrafish - Toward high-throughput automated analysis of jaw movements. IEEE International Symposium on Biomedical Imaging (ISBI): 943-947.. Chandrasekhar, A., Guo, S., Masai, I., Nicolson, T. and Wu, C-F., (2017) Zebrafish: from genes and neurons to circuits, behavior and disease. Journal of Neurogenetics : 31: 59-60.. Allen, J., Bhattacharyya, K., Asante, E., Almadi, B., Davis, J., Schafer, K., Cox, J., Voigt, M., Viator, J. and Chandrasekhar, A., (2017) Role of branchiomotor neurons in controlling food intake of zebrafish larvae. Journal of Neurogenetics : 31: ...
Neurofascin-155 IgM autoantibodies in patients with inflammatory neuropathies | Journal of Neurology, Neurosurgery & Psychiatry
In the present study, we give the first detailed work-up of patients with IgM autoantibodies against neurofascin-155. Whereas IgG autoantibodies to neurofascin-155 have been reported in several studies and are supposed to cause a distinct clinical phenotype,2 17 18 IgM neurofascin-155 autoantibodies have so far only been described in a few patients and some of them also tested positive for IgG anti-neurofascin.4 7 Autoantibodies were detectable by ELISA and were confirmed by preabsorption experiments and by Western blot in four patients, but not by binding assays with neurofascin-155 transfected HEK293 cells or murine teased fibres. Most likely, the latter methods were not sensitive enough to detect the low titres of autoantibodies as indicated by a higher sensitivity of ELISA when comparing with cell based binding assays using serum of a patients with high titres of anti-neurofascin-155 IgG.. C1q deposition was not detectable by CBA although IgM antibodies are supposed to bind complement. ...
Protein Tyrosine Phosphatase α (Ptpα) and Contactin Form a Novel Neuronal Receptor Complex Linked to the Intracellular Tyrosine...
Two experiments were carried out to address the question of whether PTPα and contactin associate in a cis or trans conformation. First, anticontactin precipitates were prepared from lysates of COS cells expressing either PTPα or contactin, or from cells coexpressing both PTPα and contactin ( Fig. 5 A, lanes 1-3), as well as from another sample made by mixing lysates from the cells expressing either contactin or PTPα ( Fig. 5 A, lane 4). Anticontactin immunoprecipitates prepared from coexpressing cells contained PTPα, but those from mixed cell lysates did not ( Fig. 5 A, bottom, lanes 7 and 8). The lack of detectable association of PTPα and contactin in the mixed lysates suggests that interaction cannot take place in a trans conformation. Still, this may require a particular presentation of these cell surface molecules in growing cells that cannot form in solubilized cell lysates. Therefore, contactin-expressing cells were trypsinized 24 h after transfection and replated in dishes ...
KAKEN - Research Projects | Role of immunoglobulin superfamily adhesion molecule F3/F11 at the late stage of neural development...
Principal Investigator：WATANABE Kazutada, Project Period (FY)：1993 - 1994, Research Category：Grant-in-Aid for General Scientific Research (C), Research Field：Neurochemistry/Neuropharmacology
CNTN1 - Contactin-1 precursor - Homo sapiens (Human) - CNTN1 gene & protein
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
CNTN4 - Contactin-4 precursor - Homo sapiens (Human) - CNTN4 gene & protein
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
2017-03: A Single-Arm, Open-label Study of Anti-Signaling Lymphocytic Activation Molecule F7 (Anti-SLAMF7) Monoclonal Antibody ...
The Total Therapy treatment regimens developed at the Myeloma Institute have demonstrated great improvement in treatment outcomes for multiple myeloma patients. However, some patients still relapse early during maintenance treatment meaning that better options are still needed. This study will evaluate a treatment regimen that alternates two different 3-drug regimens every eight weeks for patients that have previously completed autologous stem cell transplant. The two regimens are bortezomib, lenalidomide, and dexamethasone (VRD) which will be alternated with Elotuzumab, lenalidomide, and dexamethasone (Elo RD). Effectiveness will be measured by the depth of response (i.e., whether or not minimal residual disease (MRD) negative status is achieved). The rate of MRD negativity from this study will be compared to historical control data from the Total Therapy 4 trial which used continuous VRD maintenance therapy after stem cell transplant(s ...
RETRO BLUE DRESS | Cloche | Molecule F
|h1|The CLOCHE SS / 19 collection is based on shapes, volumes and textures, harmoniously blended with the color trends of the season. The convenience, refinement and gentle strokes that follow the body line reach their climax in these tracks.|/h1| |h1|ma
CONICAL TAFETTA PANTS | Cloche | Molecule F
|h1|The CLOCHE SS / 19 collection is based on shapes, volumes and textures, harmoniously blended with the color trends of the season. The convenience, refinement and gentle strokes that follow the body line reach their climax in these tracks.|/h1| |h1|ma
In neurons, generation and propagation of action potentials requires the complete | Cisplatin resistance in gastric cancer cells
In neurons, generation and propagation of action potentials requires the complete accumulation of sodium stations on the axonal initial portion (AIS) and in the nodes of Ranvier through ankyrin G scaffolding. portion (AIS), and in myelinated axons, their saltatory conduction takes place via the nodes of Ranvier (Stuart et al., 1997; Kole et al., 2008). These procedures require a specific distribution of voltage-gated sodium stations that accumulate at high density in both of these highly specific axonal subdomains, described with the segregation from the cytoskeletal adaptor complicated ankyrin G/IV spectrin (Zhou et al., 1998; for review find Salzer, 2003). This scaffolding complicated not merely concentrates voltage-gated sodium stations Nav1.2 and Nav1.6 (Boiko et al., 2003), but additionally potassium stations KCNQ2/KCNQ3 (Devaux et al., 2004; Skillet et al., 2006), cell adhesion substances neurofascin-186 (NF-186), and neuronal cell adhesion molecule (NrCAM; Davis et al., 1996; Basak et ...
Jerald M.s. Pang, Movies/TV - Filmtronic
The Best Jerald M.s. Pang Movies/TV/Books. Previous and Upcoming Content.Jerald M.s. Pang recently worked with: Alex Oloughlin, Scott Caan.
De Filmkrant :: BANGKOK DANGEROUS (Danny & Oxide Pang)
De tweelingbroers Oxide Pang Chun en Danny Pang kennen hun klassiekers, maar de beginnende regisseurs - alleen Oxide maakte tot nu toe een film, Ta fa likit (Who is running? uit 1998) - zitten nog in het stadium waarin ze zich moeilijk van hun voorbeelden kunnen loswrikken. Dat levert niet alleen open deuren, maar ook iets teveel bombast op: hun poging het extreem felle kleurenpalet van voormalig John Woo-cameraman Peter Pau te kopiëren is iets te opzichtig en de zwaar aangezette synthesizerscore veroorzaakt geborrel in de maagstreek. Maar in het ensceneren van brute geweldsscènes of achtervolgingen door broeierige steegjes tonen de heren zich meesters in de dop, en ze weten die typisch Aziatische uitbarstingen van energie, die de kijker zo aangenaam naar het hoofd kunnen stijgen, goed over te brengen ...
LGI1/CASPR2-antibody encephalitis | The Encephalitis Society
LGI1/CASPR2-antibody encephalitis is an autoimmune encephalitis in which antibodies target LGI1 (leucine-rich glioma inactivated 1) or CASPR2 (contactin-associated protein 2). Initially, typically, family members notice seizures and/or that their relative becomes forgetful, confused, drowsy and withdrawn.
Pesquisa | Portal Regional da BVS
BACKGROUND: Monoclonal antibodies (mAbs) towards CGRP or the CGRP receptor show good prophylactic antimigraine efficacy. However, their site of action is still elusive. Due to lack of passage of mAbs across the blood-brain barrier the trigeminal system has been suggested a possible site of action because it lacks blood-brain barrier and hence is available to circulating molecules. The trigeminal ganglion (TG) harbors two types of neurons; half of which store CGRP and the rest that express CGRP receptor elements (CLR/RAMP1). METHODS: With specific immunohistochemistry methods, we demonstrated the localization of CGRP, CLR, RAMP1, and their locations related to expression of the paranodal marker contactin-associated protein 1 (CASPR). Furthermore, we studied functional CGRP release separately from the neuron soma and the part with only nerve fibers of the trigeminal ganglion, using an enzyme-linked immunosorbent assay. RESULTS: Antibodies towards CGRP and CLR/RAMP1 bind to two different ...
Item # 75-001, CASPR/Neurexin IV On Antibodies, Inc.
Browse Item # 75-001, CASPR/Neurexin IV in the Antibodies, Inc. catalog including Item #,Item Name,Description,Target,Applications,Clone,IgG Isotype,Species Reactivity,Validation,Type,Format,Cross Reactivity,Expected Banding Pattern,Host,Label,Antibo
Ministro ng UK: Wala pang desisyon sa mga bakuna sa COVID-19 para sa malusog na bata - Reporter ng EU
Pillar III: Isang magkasamang pakikipagsosyo sa EU / US sa pagpapalakas sa pandaigdigang supply ng bakuna at mga therapeutics: ang EU at Estados Unidos ay makikinabang ang kanilang bagong inilunsad na Joint COVID-19 Manufacturing and Supply Chain Taskforce upang suportahan ang paggawa ng bakuna at therapeutic at pamamahagi at mapagtagumpayan ang mga hamon sa supply chain. Ang mga nagtutulungan na pagsisikap, na nakabalangkas sa ibaba, ay isasama ang pagsubaybay sa mga pandaigdigan na kadena ng suplay, pagtatasa ng pandaigdigang pangangailangan laban sa supply ng mga sangkap at mga materyales sa paggawa, at pagkilala at pagtugon sa mga bottleneck na real time at iba pang mga nakakagambalang kadahilanan para sa pandaigdigang paggawa ng bakuna at therapeutics, pati na rin ang pag-uugnay ng mga potensyal na solusyon at mga pagkukusa upang mapalakas ang pandaigdigang paggawa ng mga bakuna, mga kritikal na input, at mga pandagdag na suplay.. Pilar IV: Isang Pinagsamang Panukala ng EU / US upang ...
Best Of Financial | Great Food Options for Overcoming Hunger Pangs When Dieting
Drinking water from your ceramic water dispenser or any other source is a brilliant way to lose weight while dieting. Often, whilst we sense hungry, were genuinely dehydrated and want a drink of water. This is an smooth concept to check yourself, next time you sense hungry, have a pitcher of water and wait half of an hour. If you still experience hungry, you want to consume, but if the starvation has subsided, you then have been sincerely dehydrated. Drinking cold water makes you experience fuller, and this satiates the appetite. However, there are also foods which permit you to to conquer starvation pangs whilst dieting, here are four of them.. 1. Choose High in Fibre Foods:. Foods which can be high in fibre make us sense fuller for longer, and this will help to certainly suppress your urge for food. The greater commonplace selections would be potatoes, grains, and beans. However, a few humans are unaware that ingredients, such as nuts, apples, pears and leafy vegetable, are also very high in ...
Dr. Katherine Pang, PhD, JD, MBA, ThM, Psychologist, Dallas, TX, 75214 | Psychology Today
Dr. Katherine Pang, PhD, JD, MBA, ThM, Psychologist, Dallas, TX, 75214, (469) 828-7609, I work with adolescents, individuals, couples, and families and use cognitive behavioral techniques and strategies to address a variety of mental health issues. My emphasis is on transformative change and equipping each one of my clients with the skills to overcome the complexities of lifes challenges and find ways to successfully navigate emotional and mental pain in the process of healing. I approach each client uniquely so as to develop a treatment plan and goals that are specific to your needs and concerns.
The Pangs Stalemates & Sad Pastimes on DeepDiscount
Buy The Pangs - Stalemates & Sad Pastimes [CD] at DeepDiscount.com. Music: Rock: 677242010922. Guaranteed Lowest Price. Free Shipping on Orders over $25!
Institute Of Molecular Biophysics | Xiaodong Pang
7) X. Pang, M. J. Zhang, L. X. Zhou, F. Xie, H. Lu, W. He, S. B. Jiang, L. Yu and X. Y. Zhang. (2011) Discovery of a Potent Peptidic Cyclophilin A Inhibitor Trp-Gly-Pro. European Journal of Medicinal Chemistry. 46, 1701- ...
PleasureDelightAlways: Pangs Kitchen
This is a gathering of all food bloggers aka foodies for Chinese New Year 2016 on the eve of Hokkien CNY on Chor 8. We had it in Pangs Kitchen, Hong Kong one-Michellin star restaurant at Taman Desa. I never even know there is such a place here, snuck right inside the office building. I was running late from work so everyone was practically waiting for me starving ...
Silveira, T. L., Veloso, E. S., Gonçalves, I. N. N., Costa, R. F., Rodrigues, M. A., Cassali, G. D., Delpuerto, H. L., Pang, L., Argyle, D. & Ferreira, E., 23 Apr 2020, (E-pub ahead of print) In: Veterinary and Comparative Oncology.. Research output: Contribution to journal › Article › peer-review ...
Browsing by Author Pang, Mingxiong
Pang, Mingxiong; Woodward, Andrew; Agarwal, Vikram; Guan, Xueying; Ha, Misook; Ramachandran, Vanitharani; Chen, Xuemei; Triplett, Barbara; Stelly, David; Z Jeffrey Chen (GenomeBiology.com, 2009) ...
Nose, Palate & Tonque Surgery | Snoring Treatment, Dr Kenny Pang
Having snoring problems? Try Nose, Palate and Tonque surgeries by an ENT expert, Dr Kenny Pang, Asia Sleep Centre in Singapore. Call (65) 6836 0060 for more info.
Mga Mega-event - Coronavirus COVID-19 Response
Ang California ay may mga ipinag-aatas at rekomendasyon para sa mga mega-event para mabawasan ang transmisyon ng COVID-19. Sa page na ito: Ano ang mga mega-event Mga indoor na event Mga outdoor na event Mga mask sa mga event Higit pang impormasyon Ano ang mga mega-event Ang mga mega-event ay mga indoor na event na may 1,000 o higit pang tao at ang mga outdoor na event ay may 10,000 o higit pang tao. Kasama rito ang mga event tulad ng: Mga convention, conference, at expo Mga Concert, […]
Greenwich Academic Literature Archive
Pudney, Christopher R., Hay, Sam, Levy, Colin, Pang, Jiayun, Sutcliffe, Michael J., Leys, David and Scrutton, Nigel S. (2009) Evidence to support the hypothesis that promoting vibrations enhance the rate of an enzyme catalyzed H-tunneling reaction. Journal of the American Chemical Society, 131 (47). pp. 17072-17073. ISSN 0002-7863 (Print), 1520-5126 (Online) (doi:10.1021/ja908469m) Hay, Sam, Pudney, Christopher R., McGrory, Tom A., Pang, Jiayun, Sutcliffe, Michael J. and Scrutton, Nigel S. (2009) Barrier compression enhances an enzymatic hydrogen-transfer reaction. Angewandte Chemie International Edition, 48 (8). pp. 1452-1454. ISSN 1433-7851 (Print), 1521-3773 (Online) (doi:10.1002/anie.200805502) Hay, Sam, Pang, Jiayun, Monaghan, Phillip J., Wang, Xi, Evans, Rhiannon M., Sutcliffe, Michael J., Allemann, Rudolf K. and Scrutton, Nigel S. (2008) Secondary kinetic isotope effects as probes of environmentally-coupled enzymatic hydrogen tunneling reactions. ChemPhysChem, 9 (11). pp. 1536-1539. ISSN ...
Pang Araw-Araw Na Mga Bagay Na Di Magtatagal Ay Mawawala Na
Chargers that you just cant afford to lose will soon become unnecessary. In the wireless world of Bluetooth, NFC, and Wi-Fi networking, all we might need will be a charging surface - without any cords, of course. You might think this has already been created by Tesla, but theres more.. There is a chance that remote charging may soon become a reality, and you will be able to charge your phone from anywhere without any physical contact at all.. Life may seem much more comfortable with all these things around us. But once gone, you might think that you never needed them at all. What do you think will be the result of such drastic changes? Share your thoughts with us in the comments below.. ...
About Us - 香港腦脊中風及痛症顧問
中風微創手術, Endovascular therapy, 內血管治療, 腦內血管介入治療, 腦瘤, 腦血瘤, 大腦麻痺, 腦外科, 神經外科, 彭家雄, Pang Ka Hung, Peter Pang, 中風急救, 中風治療, Stroke, PCI, iv rtPA, 薄血藥, 腦血管支架, 腦血管狹窄, 預防中風, 中風風險評估, 黃金3小時, 黃金8小時
TPLFs Curious Position And The Birth Pangs For True Democracy? - The Daily Horn News
Earlier this year, Tigray region had been urging the federal government to stick to the original schedule and carry out national elections for several months.
Vengeance is a Golden Blade (1969) -- Silver Emulsion Film Reviews
Vengeance is a Golden Blade [飛燕金刀] (1969) Starring Chin Ping, Yueh Hua, Tang Ching, Kao Pao Shu, Goo Man-Chung, Pang Pang, Lee Pang-Fei, Chiu Hung, Law Hon, Ngai Ping-Ngo, Wong Ching Ho, Hao Li-Jen, Tsang Choh-Lam Directed by Ho Meng-Hua Expectations: High. You cant go wrong with that title, right? The reason I made it…
Kaharian ng AKONILANDIYA: Akoy nilandi niya
Buweno, sa ngalan ng aking kaharian at nang akin nasasakopan, gusto kong magpasalamat kay BINO. Maraming salamat parekoy, dahil binigyan mo ko ng isa pang dahilan para magpatuloy sa pagbablog, hehehe, itong mga nakaraan araw kasi parang natatamod na ako magblog, at dahil dito nagkaroon ako ng panibago at kakaibang enerhiya sa katawan upang ipagpatuloy ang mga pinaglalaban ko sa buhay, lalo na ang hangarin ng aking kaharian na gulohin ang matitino ninyong mga utak. MABUHAY ka BINO ...
My Personal Script | Phyllis Moorman
Chronic pain is written for me; morning stiffness, evening pangs, uncooperative muscles. The storyline is scripted by doctors and researchers. How the story plays out, however, is my privilege as the lead actor to put my personal spin on the lines. I rise like the sun, slowly from the horizon yet bright and welcoming. Staging…
Late enrollment papayagan hanggang Nobyembre: DepEd | ABS-CBN News
Inihayag ngayong Miyerkoles ng Department of Education na maaari pang humabol sa enrollment ang mga estudyante sa public schools hanggang Nobyembre.
Are you one of those moms like me, who panicked when the news about JE victims circulated online?. It was very alarming to hear this but the good news is wala tayong dapat ika-worry, dahil wala pang outbreak ng JE sa Pilipinas mga inays.. ...
Biochemistry - Pacific Standard
New research shows that fatherhood can make you a better man. While men dont endure the pangs of childbirth, studies show they get some of the same cognitive and physical benefits from their own altered biochemistry, which occurs once the baby arrives. ...
hypertension | Heart
Yang Zhao, Ming Zhang, Xinping Luo, Chongjian Wang, Linlin Li, Lu Zhang, Bingyuan Wang, Yongcheng Ren, Junmei Zhou, Chengyi Han, Chao Pang, Lei Yin, Tianping Feng, Jingzhi Zhao, Dongsheng Hu ...
Oncotarget | https://doi.org/10.18632/oncotarget.12922 Wei Shi, Yanxue Yin, Yao Wang, Bo Zhang, Pei Tan, Ting Jiang, Heng Mei, Jun Deng, Huafang Wang, Tao Guo, Zhiqing Pang, Yu Hu
APS -2009 APS April Meeting - Session Index APR09
C.M. Campbell, S. Chouhan, C. Guenaut , D. Lawton, F. Marti, J. Ottarson, S. Schwarz, P. Zavodszky, A.F. Zeller, G. Bollen, D.J. Morrissey, G. Pang ...
Gamot para matagal labasan ang lalake - Revitol Skin Care - Nov 29, 2017
Gamot para matagal labasan ang lalake - MGA PANALANGIN: GAYUMA ( pambabae at pang lalake). Ideal for treating acne spots directly.
Browsing DR-NTU | DR-NTU
Wang, Le; Wan, Zi Yi; Bai, Bin; Huang, Shu Qing; Chua, Elaine; Lee, May; Pang, Hong Yan; Wen, Yan Fei; Liu, Peng; Liu, Feng; Sun, Fei; Lin, Grace; Ye, Bao Qing; Yue, Gen Hua ...
Smoking | Tinnitus Talk Support Forum
Hi All, Does anyone believe that by stopping smoking will help reduce the pangs of the tinnitus... Has anyone out there quit and has helped there...
got lactate?: Ups & Downs Abound
Weeks total came out to a little under 81 miles, with a rolling 8-day total (Sunday-Sunday) of 103+ miles. The most important thing is that Im feeling healthy. Theres an errant ache here or a pang there, but nothing too concerning, and all part of what happens when pushing ones body (and mind) into uncharted training territory. However, Ive shuffled things around and am making this week a cutback week, with somewhere around 65 miles on tap. That was close to my peak week last year, so Im pleased with the progress Ive made ...
Put together mutagenesis of the phosphorylated ... retained
The Ig-like domains of L1 can consider component in homophilic and heterophilic interactions ... condition models and human patients of Advertisement.
Ig Superfamily Molecules in the Nervous System, книга. Peter Sonderegger - ReadRate
Ig Superfamily Molecules in the Nervous System автора Peter Sonderegger можно найти, купить на сайте ReadRate.com. На нашем сервисе вы найдете отзывы о книге.
NRCAM (neuronal cell adhesion molecule)
NRCAM (neuronal cell adhesion molecule), Authors: Justyna Janik, Barbara Czarnocka. Published in: Atlas Genet Cytogenet Oncol Haematol.
ISOLATED POPULATIONS OF ADULT RENAL CELLS AND METHODS OF ISOLATING AND USING SAME - Patent application
TABLE-US-00004 TABLE 4 Cell and biological adhesion Fold Symbol Gene name Gene assignment change CLDN7 claudin 7 Involved in the formation of 2.74 tight junctions between epithelial cells PCDHB5 Protocadherin Member of the 3.32 beta-5 protocadherin beta gene cluster CLDN3 Claudin 3 Member of the claudin 3.93 family, is an integral membrane protein and a component of tight junction strands. CNTN6 contactin 6 Contactins mediate cell 3.09 surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. PKHD1 polycystic kidney Localized predominantly at 3.38 and hepatic the disease 1 apical domain of polarized epithelial cells, suggesting it may be involved in the tubulogenesis and/or maintenance of duct-lumen architecture. PCDHB2 protocadherin The extracellular domains 2.94 beta 2 interact in a homophilic manner to specify differential cell-cell connections. CDH1 E-cadherin cell adhesion molecule 3.27 (epithelial) CX3CL1 hemokine ...
Yi Pang, PhD, OD - Annals of Eye Science
Dr. Pang is a professor of optometry and the Assistant Dean for Research at the Illinois College of Optometry. Dr. Pang is active in both didactic teaching, including lecture and lab, and clinical teaching. Dr. Pang is an attending optometrist in the Pediatric and Binocular Vision service at the Illinois Eye Institute. Her research interests are in the areas of amblyopia, strabismus, and binocular vision function. Currently, she is the principal investigator for several NIH funded studies and other research projects. She has authored more than 110 peer reviewed publications and abstracts. In addition, Dr. Pang is in the editorial boards of four prestigious journals and is an active scientific referee for thirteen major journals. Dr. Pang is a fellow of the American Academy of Optometry and a diplomate of American Board of Optometry. ...
Contactin 1, Polyclonal, Invitrogen™ 100μL; Unconjugated Contactin 1, Polyclonal, Invitrogen™
Contactin 1, Polyclonal, Invitrogen™ 100μL; Unconjugated Contactin 1, Polyclonal, Invitrogen™ Primary Antibodies Ci to Cx
CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders • Research - Institut...
Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. Mutations of
Three-membered ring or open chain molecule - (F3C)F2SiONMe2 a model for the alpha-effect in silicon chemistry
F3C)F2SiONMe2 was prepared from LiONMe2 and F3CSiF3- It was characterized by gas IR and multinuclear solution NMR spectroscopy and by mass spectrometry. Its structure was elucidated by single crystal X-ray crystallography and by gas electron diffraction. (It exists as a conformer mixture.) Important findings were extremely acute SiON angles [solid 74.1 (1)degrees, gas anti 84.4(32)degrees and gauche 87.8(20)degrees] and short (SiN)-N-... distances [solid 1.904(2) angstrom]. The bending potential of the SiON unit was calculated at the MP2/6-311++G(3df,2dp) level of theory and appears very flat and highly asymmetric. The calculated atomic charges (NPA) are counterintuitive to the expected behavior for a classical Si-N dative bond, as upon formation of the (SiN)-N-... bond electron density is transferred mainly from oxygen to nitrogen, while the silicon charge is almost unaffected. Despite the molecular topology of a three-membered ring, the topology of the electron density shows neither a bond ...
CNTN2 Gene - GeneCards | CNTN2 Protein | CNTN2 Antibody
Complete information for CNTN2 gene (Protein Coding), Contactin 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
CNTN6 Gene - GeneCards | CNTN6 Protein | CNTN6 Antibody
Complete information for CNTN6 gene (Protein Coding), Contactin 6, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
OriGene - CNTN1 (NM 175038) cDNA Clone
CNTN1 - CNTN1 (untagged)-ORIGENE UNIQUE VARIANT 1 of Human contactin 1 (CNTN1), available for purchase from OriGene - Your Gene Company.
Most recent papers with the keyword PIKE GTPase | Read by QxMD
The neurofibromatosis 2 (NF2) tumor suppressor protein merlin is commonly mutated in human benign brain tumors. The gene altered in NF2 was located on human chromosome 22q12 in 1993 and the encoded protein named merlin and schwannomin. Merlin has homology to ERM family proteins, ezrin, radixin, and moesin, within the protein 4.1 superfamily. In efforts to determine merlin function several groups have discovered 34 merlin interacting proteins, including ezrin, radixin, moesin, CD44, layilin, paxillin, actin, N-WASP, betaII-spectrin, microtubules, TRBP, eIF3c, PIKE, NHERF, MAP, RalGDS, RhoGDI, EG1/magicin, HEI10, HRS, syntenin, caspr/paranodin, DCC, NGB, CRM1/exportin, SCHIP1, MYPT-1-PP1delta, RIbeta, PKA, PAK (three types), calpain and Drosophila expanded ...
Fujita N et al. (2000), An essential role of the neuronal cell adhesion... - Paper
FIG. 3. Distribution of contactin protein in stage 37/8 embryos, visualized by whole-mount immunocytochemistry. (A) A lateral view of the anterior 2/3 of the stained embryo, showing nervous tissue-specific distribution of contactin immunoreactivity. (B) An enlarged dorsal view of the brain portion of the embryo shown in (A). Axon tracts in the brain and primary olfactory region (arrowhead) are contactin positive. (C, D, and G) Cross sections of the stained embryo at the levels of midbrain (C), hindbrain (D), and posterior spinal cord (G). Contactin is expressed in the postoptic commissure and the optic chiasm of the lateral diencephalon (arrowheads in C) and the fasciculus longitudinalis medialis in the ventral marginal region (arrowheads in D). (E and F) Enlarged lateral (E) and dorsal (F) views of a part of the embryos, showing contactin-positive dorsal and ventral spinal fascicles. An arrow and an arrowhead in (E) represent contactin-positive cell bodies of a RB neuron and an EM neuron, ...
Clinical Reasoning: A 30-year-old man with headache and sleep disturbance | Neurology
Our patient underwent numerous investigations: serologic tests included inflammatory markers (erythrocyte sedimentation rate, C-reactive protein, and antinuclear antibody), aquaporin-4 (AQP4) antibodies, myelin oligodendrocyte glycoprotein (MOG) antibodies, and infectious testing including HIV, tuberculosis, and syphilis screening, bacterial cultures, and fungal cultures; all results were normal. CSF analysis revealed the following: total nucleated cells (TNC), 12 cells/μL; erythrocytes, 1,000 cells/μL; protein, 98 mg/dL; glucose, 69 mg/dL; 0 oligoclonal bands; negative cytology and flow cytometry; negative bacterial and fungal testing. A CT chest/abdomen/pelvis was unremarkable.. Both serum and CSF autoimmune encephalopathy panels were sent to Mayo Clinic, which includes antibodies directed against N-methyl-D-aspartate receptor (NMDAR), leucine-rich glioma-inactivated 1 (LGI-1), contactin-associated protein 2 (CASPR2), glutamic acid decarboxylase (GAD65), GABAB receptor, ...
Dr Jiayun Pang | Staff profiles - Pharmaceutical, Chemical & Environmental Sciences | Department of Pharmaceutical, Chemical ...
Our knowledge of enzyme-catalysed reactions has traditionally been gained from crystallography and solution studies. However, due to rapid developments in computer power and software, computational tools are playing an increasingly important role in obtaining an atomistic understanding of how enzymes achieve enormous rate accelerations.. The computational approaches can reveal aspects of a reaction that are difficult to access through experiment. Thus, combining the strength of the two can provide very detailed insight into enzyme catalysis, the knowledge of which could lead to the development of new drugs (most function as inhibitors of enzymes) and the design of efficient catalysts with many industrial applications.. Dr Pangs research aims at elucidating, from the quantum phenomenon to the macromolecular levels, fundamental mechanisms of enzyme activity. The current focus is to explore how protein dynamics - ranging from local atomic vibrations on a femto to picosecond time scale to larger ...
Invitation to the seminar by Dr. Paul Pang, Unitec, NZ | KMUTT
Invitation to the seminar by Dr. Paul Pang, the Decentralized Machine Learning Intelligence (DMLI) Laboratory/ Department of Computing, Faculty of Creative Industries and Business, Unitec Institute of Technology, New Zealand in the topic Incremental Linear Discriminant Analysis over Compressed Data Streams on Monday 29th October 2012 at 10.30 น. - 12.00, the meeting room 3/3, 3rd floor, SIT.. Please call 02-470-9850 for more information. ...
CD171 / L1CAM antibody | acris-antibodies.com
L1, also known as L1CAM, is a transmembrane protein; it is a neuronal cell adhesion molecule, member of the L1 protein family, of 200-220 kDa, and…
Cntn1 monoclonal antibody, clone AR3 (RPE) - (MAB11960) - Products - Abnova
Mouse monoclonal antibody raised against synthetic peptide of Cntn1. A synthetic peptide corresponding to amino acids 21-37 at extracellular domain of rat Cntn1. (MAB11960) - Products - Abnova
Cntn1 monoclonal antibody, clone S73-20 (HRP) - (MAB11957) - Products - Abnova
Mouse monoclonal antibody raised aginst synthetic peptide of Cntn1. A synthetic peptide corresponding to amino acids of 21-37 at extracellular domain of rat Cntn1. (MAB11957) - Products - Abnova
کانتکتین ۱ - ویکیپدیا، دانشنامهٔ آزاد
کانتکتین ۱ (انگلیسی: Contactin 1) یک پروتئین است که در انسان توسط ژن «CNTN۱» کُدگذاری میشود. پروتئینی که توسط این ژن ساخته میشود، در واقع، عضوی از اَبَرخانوادهٔ ایمنوگلوبولینهاست. کانتکتین ۱، یک پروتئین غشاء عصبی متصل به گلیکوزیلفسفاتیدیلاینوزیتول است که در اتصال سلولی نقش دارد. احتمال دارد این پروتئین در تشکیل اتصالات آکسونی در جریان رشد و تکامل دستگاه عصبی نقش داشته باشد. دو گونه پیرایش آرانای مختلف برای این ژن یافت شدهاست که ایزوفرمهای پروتئینی مختلفی را میسازند. ...
Disposition of axonal caspr with respect to glial cell membranes: Implications for the process of myelination
Neurofascin-155 (NF155) and caspr are transmembrane proteins found at discrete locations early during development of the nervous system. NF155 is present in the oligodendrocyte cell body and processes, whereas caspr is on the axonal surface. In mature nerves, these proteins are clustered at paranode …
MORE Power From Your HGH Supplement Therapy Using 3 Simple Steps
Drinking water, and lots of it, is always healthy and thats more than welcome!. Natural and safe to consume, one cannot have too much water. Matter of fact, its highly advisable for one to drink water as much as half of their weight in pounds.. Heres a little-known fact - dehydration often disguises itself as hunger pangs. And these hunger pangs often drive us rushing to the dining table. HOWEVER, its been proven that a glass of water is more than enough to ward off those hunger pangs…and that means you wont be tempted to eat unnecessarily.. And lets NOT forget about the cleansing effects of water, especially for your colon! Your colon, by the way, is usually filled with harmful substances and waste buildup. Getting rid of them means a cleaner colon that leads to a healthier and better-performing body.. ...
Contactin 5 Antibody (PA5-58814)
Invitrogen Anti-Contactin 5 Polyclonal, Catalog # PA5-58814. Tested in Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC) and Immunohistochemistry (IHC) applications. This antibody reacts with Human samples. Supplied as 100 µL purified antibody (0.2 mg/mL).
Cntnap4 MGI Mouse Gene Detail - MGI:2183572 - contactin associated protein-like 4
View mouse Cntnap4 Chr8:112570043-112882717 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Eggs, Larvae and Osteological Development of the Northern Searobin, <em>Prionotus carolinus</em> (Pisces,...
Egg, larval and osteological development of the northern searobin, Prionotus carolinus, is described, principally from laboratory reared specimens. Egg diameter ranges from 0.87 to 0.97 mm, and the eggs contain 11 to 37 oil globules, which migrate to various locations within the egg during development. Gastrulation occurs at 27 hr, embryo is halfway around the yolk at 52 hr, and hatching occurs between 120 and 155 hr at 15°C. Prominent pigmentation of the embryo consists of a dark cluster of chromatophores just posterior to the developing eye and the beginning of a transverse band halfway between the vent and notochord tip just prior to hatching. Newly-hatched larvae range from 2.8 to 3.1 mm. The transverse band of pigment is fully developed and is an important characteristic in identifying early P. carolinus larvae. The pectoral fins are present at hatching and remain a characteristic feature.. Adult meristics are complete by 7.0 mm. Larval head length increases during development becoming ...
Mga Modelo ng Mga Daanang 3D FlatPyramid
3D Mga Modelo ng Highway Structures sa Flatpyramid.. Ang isang highway ay isang daan para sa mataas na bilis ng trapiko ng kotse na walang mga interseksyon sa isang antas na may iba pang mga kalsada, tren o tram track, o mga landas ng pedestrian o bisikleta.. Idinisenyo para sa mga high-speed na sasakyan, ang mga highway para sa bawat direksyon ng paglalakbay ay pinaghihiwalay ng isang hadlang o iba pang mga teknikal na paraan ng konstruksiyon at mayroong hindi bababa sa dalawang daan para sa pagmamaneho sa bawat direksyon, at kadalasan ng malawak na margin para sa pagpapahinto ng mga kotse sa mga hindi inaasahang sitwasyon.. Ang mga paglabas sa mga motorway ay nilagyan ng mga braking at acceleration lane. Ipinagbabawal na pumasok sa mga motorway para sa mga sasakyan na ang pinakamataas na pinapayagang bilis ay mas mababa sa isang tiyak na halaga (halimbawa, mga moped o traktora, depende sa tiyak na bilis sa estado), pati na rin sa bisikleta at transportasyon ng kabayo. Gayundin, ipinagbabawal ...
SoftPot Membrane Potentiometer - 100mm - SK Pang Electronics Ltd
These are very thin variable potentiometers. By pressing down on various parts of the strip, the resistance linearly changes from 100Ohms to 10,000Ohms allowing the user to very accurately calculate the relative position on the strip. Can be used as an accurate positional indicator for CNC head positioning, variable us
Day 4 of Pylera intense hunger pangs:( - helico.com Forums
A new anti-spam extension has been installed in this forum. If you have problem registering or login the forum, please do not hesitate to email the admin ...
Mit kell tudni a pang sos sz vel gtelens gr l? - H ziPatika
A sz vel gtelens g s lyos llapot, ilyenkor a sz v nem k pes hat konyan v rt pump lni a szervezetbe - ennek okai s t netei sokf l k lehetnek. A miel bbi felismer s letment !
Best 5 Snacks to Beat Quick Hunger Pangs - ChaaiCoffee
Snacking is as important as any meal of the day. If you ever heard munching all day is not good. Read this to know how munching and snacking is healthful..
Topical Bible: Convulsion
See NAS NIV). Isaiah 21:3 Therefore are my loins filled with anguish; pangs have taken hold upon me, as the pangs of a woman in travail: I am pained so that I cannot hear; I am dismayed so that I cannot see ...
2019-01-27 - The Online Citizen
The death of actor Aloysius Pang (Pang) while serving his National Service duties caused me sadness and anger. Sadness over the loss of a young life full of unfulfilled potential and anger because of a seeming lack of accountability on the part of the government over these deaths. While inquiries are held when incidences such as these occur, they occur …. Read More » ...
Contactin-associated protein-like 2 protein, or Caspr2, is a neuronal transmembrane member of the Neurexin family. Structural features of Caspr2 include epidermal growth factor repeats, laminin G domains, F5/8 type C domain, fibrinogen-like domains, and PDZ binding sites. Caspr2 is a cell adhesion molecule as well as a receptor. It is involved in mediating cell-cell interactions in the nervous system and involved in neural-glia interactions and clustering of potassium channels in myelinated axons. It is expressed at the juxaperanodal region of nodes of Ranvier in the CNS and PNS. Changes in expression have been associated with increased susceptibility to autism and epilepsy ...
Difference between revisions of Archived announcements - Usenet Big-8 Management Board
2017-09-13: [[Nan:2017-09-13-mvi-rec.sport.pro-wrestling.moderated,Moderator Vacancy Investigation (MVI) rec.sport.pro-wrestling.moderated ...
Difference between revisions of Archived announcements - Usenet Big-8 Management Board
2011-03-27: [[Nan:2011-03-27-rfd-news.admin.net-abuse.blocklisting,2nd RFD: news.admin.net-abuse.blocklisting moderated (remove) LAST CALL FOR COMMENTS ...
Baxter Bir och Diesel BIR och BIG-2! | Royalty Rocks
Kennel Royalty Rocks-Versatile dogs for versatile work Vi föder upp Bracco Italiano med inriktning på jakt. Vår kennel ligger belägen i Olofstorp ca 2 mil utanför Göteborg. Vi är aktiva inom lydnad, jakt, utställning och viltspår.
Notch signaling pathway
CNTN6 Polyclonal Antibody (CAB14275)OverviewTitle:CNTN6 Polyclonal Antibody (CAB14275)Size:100µLCode:CAB14275Host Species:RabbitPurification:Affinity purificationIsotype:IgGBackgroundThe protein encoded by this gene is a member of the immunoglobulin ...
Antibody: Images for Cntn1 Ab3
Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari. ...
[email protected]: Browsing MIT Open Access Articles by Title
Kan, Lijuan; Grozhik, Anya V.; Vedanayagam, Jeffrey; Patil, Deepak P.; Pang, Nan; Huang, Yi-Chun; Joseph, Brian; Lin, Ching-Jung; Despic, Vladimir; Guo, Jian; Yan, Dong; Kondo, Shu; Deng, Wu-Min; Jaffrey, Samie R.; Lai, Eric C.; Lim, Kok Seong; Dedon, Peter C (Nature Publishing Group, 2017-07) ...
pandurog maliit na pandurog ng bato para sa
Patunayan na ang mga piraso ay maliit Kung hindi pindutin ang para sa 15 higit pang mga segundo Ad Paraan 2 ng 3 Crush na may isang gulugod na slicer ng gulay Bumili ng isang spiral na gulay slicer Ito ay katulad ng isang mansanas na mansanas Kailangan mong ipakilala ang gulay at i-on ang pihitan sa pamamagitan ng talim na may isang paggalaw ng spiral Mayroong ibat ibang mga uri ng ...
Kaharian ng AKONILANDIYA: Palabas II: May tanong ka ba? May sagot ako eh.
Ano ang dapat gawin once na malaman mo na lahat? Walang dapat gawin, Hangat wala pang namamagitan sa inyo na special na emotion at relasyon ay wala kang dapat gawin. Steady ka lang ineng, steady maligaya ka lang ang dapat. Wala kang obligasyon/dapat na gawin dahil lang sa nalaman mo na tinatangi ka ng isang tao o may pagtingin sayo ang isang tao. Kumilos ka ayun sa kilos mo, tumawa ka ayun sa tawa mo, lumakad ka ayun sa lakad mo, at umutot ka ayun sa utot mo. Tuloy mo lang ang buhay mo, kung ano ka, at kung sino ka ...
Suunto Spartan Sport Wrist HR - Pagsisimula
Kapag tapos na ang wizard, i-charge ang relo gamit ang kasamang USB cable hanggang sa puno na ang charge ng baterya.. Kailangan mong i-download at i-install ang SuuntoLink sa iyong PC o Mac upang kumuha ng mga software update para sa iyong relo. Lubusan naming inirerekomenda ang pag-a-update ng iyong relo kapag available na ang bagong release ng software.. Bumisita sa www.movescount.com/connect para sa higit pang impormasyon. ...
Mga tunog at vibration
Ginagamit ang mga alerto na tunog at vibration para sa mga notification, alarma at iba pang mga mahalagang kaganapan at pagkilos. Parehong maaaring i-adjust sa mga setting sa ilalim ng General (Pangkalahatan) » Tones (Mga Tunog).. Para sa bawat isa, maaari kang pumili sa mga sumusunod na opsyon:. ...
Pres. Aquinos SONA 2011 anchored on anti-wangwang policy - Blogwatch
Photo by: Benhur Arcayan/ Malacanang Photo Bureau). President Aquino, who arrived at Batasang Pambansa via the Presidential chopper passed 3:30 in the afternoon, opened his 2011 SONA recalling his anti-siren campaign when he assumed presidency last year. The President relates the policy as a symbol of change as wangwang signifies abuse of authority over the past years.. Humarap po ako sa inyo noong aking inagurasyon at sinabing: Walang wang-wang sa ating administrasyon. At ngayon, patuloy nating itinitigil ito. Naging hudyat at sagisag po ito ng pagbabago, hindi lamang sa kalsada, kundi pati na rin sa kaisipan sa lipunan. PNoy stated as he delivers his speech.. Sa matagal na panahon, naging simbolo ng pang-aabuso ang wang-wang….. Ang mga dapat naglilingkod ang siya pang nang-aapi. Ang panlalamang matapos mangakong maglingkod-iyan po ang utak wang-wang. Aquino added.. President Aquino continued his speech with the rundown of accomplishments of his administration for the past year citing ...
OSA | Wide and scalable field-of-view Talbot-grid-based fluorescence microscopy
Shuo Pang,1,*,† Chao Han,1,† Mihoko Kato,2 Paul W. Sternberg,2 and Changhuei Yang1 1Department of Electrical Engineering, California Institute of Technology, Pasadena, California 91125, USA 2Howard Hughes Medical Institute and Division of Biology, California Institute of Technology, Pasadena, California 91125, USA †These authors contributed equally to this work. *Corresponding author: [email protected] ...
As The World Churns
Ive been doing some thinking(theres a surprise), and I realized just a short while ago that nothing ever works out for me...whenever I get close with anyone, or really start to open up to someone to the point where I start feeling those little pangs in the back of your spleen that threaten to become something that may grow into love(gasp...not the l word) someday, whenever I get to that point, extenuating circumstances present themselves like clockwork, and put simply...fuck everything up. So I thought about it for quite some time, and I was *this* close to just deciding to get one up on circumstances and just not get close to anyone ever again...I thought I was a strong person, I thought I could stand up to all the shit that I incur just because I get so close with people so quickly, but Ive run out of energy...and mistake me not when I say that it requires a VERY LARGE portion of energy to put up with the scarring emotional shit you go through when you open up to someone and something gets ...
Oncothermia Journal Volume 10 | Oncotherm
Clifford LK Pang (2014) The Orientation, Application and Efficacy Evaluation of Hyperthermia in Integrative Natural Therapies of Cancer. Oncothermia Journal 10:15-27
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the ... The subgroup consists of six members now referred to as contactin 1-6, but historically they had different names as shown in ... the table below: Shimoda, Yasushi; Watanabe, Kazutada (1 January 2009). "Contactins". Cell Adh Migr. 3 (1): 64-70. PMC 2675151 ...
Contactin-3 is a protein that in humans is encoded by the CNTN3 gene. GRCh38: Ensembl release 89: ENSG00000113805 - Ensembl, ... "Entrez Gene: CNTN3 contactin 3 (plasmacytoma associated)". Human CNTN3 genome location and CNTN3 gene details page in the UCSC ... 2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression ...
... , also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene. The protein encoded by this gene ... "Entrez Gene: CNTN1 contactin 1". Sakurai T, Lustig M, Nativ M, Hemperly JJ, Schlessinger J, Peles E, Grumet M (Feb 1997). " ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ...
... contactin 6, and contactin 4 candidate chromosome 3p26pter tumor suppressor genes in ovarian cancer". International Journal of ... Contactin 6 is a protein in humans that is encoded by the CNTN6 gene. The protein encoded by this gene is a member of the ... "Entrez Gene: Contactin 6". Manderson EN, Birch AH, Shen Z, Mes-Masson AM, Provencher D, Tonin PN (May 2009). "Molecular genetic ... Contactin-6) at the PDBe-KB. v t e (Articles with short description, Short description matches Wikidata, Genes on human ...
Contactin-2 is a protein that in humans is encoded by the CNTN2 gene. The protein encoded by this gene is a member of the ... "Entrez Gene: CNTN2 contactin 2 (axonal)". Traka M, Goutebroze L, Denisenko N, Bessa M, Nifli A, Havaki S, Iwakura Y, Fukamauchi ...
Contactin-4 is a protein that in humans is encoded by the CNTN4 gene. The protein encoded by this gene is a member of the ... 2006). "The contactin 4 gene locus at 3p26 is a candidate gene of SCA16". Neurology. 67 (7): 1236-41. doi:10.1212/01.wnl. ... "Entrez Gene: CNTN4 contactin 4". "Gene for brain connections linked with autism". www.newsdaily.com. Archived from the original ... 2004). "Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome". Am. J. ...
Overseas Telecommunications Commission
CONTACT - in-house magazine of OTC. Masterton, R and Prances M; Invisible Bridges, Australia and International ...
Contactin-associated protein-like 2 is a protein that in humans is encoded by the CNTNAP2 gene. Since the most recent reference ... "Entrez Gene: CNTNAP2 contactin associated protein-like 2". Ashley, Euan A. (16 August 2016). "Towards precision medicine". ... Nakabayashi K, Scherer SW (April 2001). "The human contactin-associated protein-like 2 gene (CNTNAP2) spans over 2 Mb of DNA at ... Overview of all the structural information available in the PDB for UniProt: Q9UHC6 (Contactin-associated protein-like 2) at ...
Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene. This gene product belongs to ... "Entrez Gene: CNTNAP4 contactin associated protein-like 4". Human CNTNAP4 genome location and CNTNAP4 gene details page in the ...
Node of Ranvier
... such as tenascin R and the cell-adhesion molecules neurofascin and contactin. Contactin is also present at nodes in the CNS and ... At CNS nodes, the axonal proteins also include contactin; however, Schwann cell microvilli are replaced by astrocyte perinodal ...
Contactin, also known as F3 or F11, associates with beta 1 as shown via co-immunoprecipitation. Fibronectin-like (FN-like) ... Shah BS, Rush AM, Liu S, Tyrrell L, Black JA, Dib-Hajj SD, Waxman SG (August 2004). "Contactin associates with sodium channel ... "Contactin associates with Na+ channels and increases their functional expression". The Journal of Neuroscience. 21 (19): 7517- ...
Gollan L, Salomon D, Salzer JL, Peles E (December 2003). "Caspr regulates the processing of contactin and inhibits its binding ... "Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction". Current Biology. 12 ...
Andrew D. Huberman
"Contactin-4 mediates axon-target specificity and functional development of the accessory optic system". Neuron. 86 (4): 985-999 ...
... members also bind "heterophilically" to members of the contactin or CNTN1 family. L1 family members bind to many ...
"Entrez Gene: Contactin associated protein 1". "OMIM Entry- * 602346 - CONTACTIN-ASSOCIATED PROTEIN 1; CNTNAP1". omim.org. ... "Contactin-Associated Protein (Caspr) and Contactin Form a Complex That Is Targeted to the Paranodal Junctions during ... CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 ... The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino ...
Heritability of autism
January 2008). "Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum ...
5 had antibodies against Contactin-2 and 18 (19%) had antibodies with unknown specificity. Of the patients with Contactin-2 ... 2010). "Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin- ... 19 had antibodies reacting with Contactin-associated protein 2 (CASPR 2), ...
Generalized epilepsy with febrile seizures plus
This extracellular region is similar to the cell adhesion molecule contactin and other cell adhesion molecules. It is believed ...
In order to form a paranodal junction, Caspr and contactin form a complex with neurofascin 155. It has been shown that ... neurofascin 155 protein clusters then bring Caspr and contactin into the membrane to form the complex, which allows the ...
Shah BS, Rush AM, Liu S, Tyrrell L, Black JA, Dib-Hajj SD, Waxman SG (August 2004). "Contactin associates with sodium channel ...
Faivre-Sarrailh C, Banerjee S, Li J, Hortsch M, Laval M, Bhat MA (October 2004). "Drosophila contactin, a homolog of vertebrate ... contactin, is required for septate junction organization and paracellular barrier function". Development. 131 (20): 4931-42. ...
Compton-North congenital myopathy
"Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital ...
1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine ...
CEE 7 standard AC plugs and sockets
Schuko is an abbreviation for the German word Schutzkontakt, which means "Protective contact" - in this case "protective" ...
Inflammatory demyelinating diseases of the central nervous system
... contactin 1 (CNTN1), contactin associated protein 1 (CASPR1) and gliomedin. All of them nodal and paranodal proteins. Several ...
Chronic inflammatory demyelinating polyneuropathy
Autoantibodies to components of the Ranvier nodes, specially autoantibodies the Contactin-associated protein 1 (CASPR), cause a ... contactin-1 and caspr-1. These cases are special not only because of their pathology, but also because they are non-responsive ...
Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: ...
... beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ...
... beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ...
Multiple sclerosis research
... contactin 1 (CNTN1), contactin associated protein 1 (CASPR1) and gliomedin. All of them nodal and paranodal proteins. Anti-TNF ...
Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: Clinical relevance of IgG isotype
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Molyduval Contactin LKA 2 HV Kontaktfett
Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP | Neurology Neuroimmunology &...
Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP. Clinical relevance of IgG isotype. Andrea ... Antibodies to cell adhesion molecules of the paranodal complex, neurofascin-155 (Nfasc155), contactin-1 (CNTN1), and contactin- ... Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP ... ANOVA = analysis of variance; Caspr1 = contactin-associated protein 1; CNTN1 = contactin-1; GFP = green fluorescent protein; ...
- Methods Antibodies to neurofascin-155 (Nfasc155), neurofascin-140/186 (Nfasc140/186), contactin-1 (CNTN1), and contactin-associated protein 1 (Caspr1) were detected with ELISA and/or cell-based assay. (neurology.org)
- The concurrence of anti-contactin 1 (CNTN1) antibody-associated chronic inflammatory demyelinating polyneuropathy (CIDP) and membranous nephropathy (MN) has previously been reported in the literature. (frontiersin.org)
- 1) We identified a de novo chromosome 7q inversion disrupting Autism susceptibility candidate 2 (AUTS2) and Contactin Associated Protein-Like 2 (CNTNAP2) in a child with cognitive and social delay. (hacettepe.edu.tr)
- Genotype-phenotype correlation in contactin-associated protein-like 2 (CNTNAP-2) developmental disorder. (cdc.gov)
- We identified Contactin as the adhesion molecule responsible for this phenotype. (houstonmethodist.org)
- We show that Contactin expression is related to IKAP expression, suggesting that IKAP regulates Contactin levels for appropriate cell-cell adhesion that could modulate neuronal growth of PNS neurons during development. (houstonmethodist.org)
- This wide role in neural ontogenesis is consistent with the recognized interaction of F3/Contactin with developmental control genes belonging to the Notch pathway. (uniba.it)
- F3/Contactin is differentially expressed in distinct populations of central and peripheral neurons and in some non-neuronal cells. (uniba.it)
- Transgenic models allowed to follow F3/Contactin promoter activation in vivo and to modify F3/Contactin gene expression under a heterologous promoter, which resulted in morphological and functional phenotypes. (uniba.it)
- Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. (acibadem.edu.tr)
- Contactin-associated protein 1 (Caspr1), also known as Neurexin-4, Paranodin, and NCP1, is an approximately 190 kDa transmembrane protein that is concentrated at paranodal junctions of axons during myelination. (rndsystems.com)
- Using mouse models, Huberman led a team demonstrating that two proteins, Contactin-4 and amyloid precursor protein, act during early development to establish and reinforce the accessory optic system. (nih.gov)
- Likewise, in the absence of amyloid precursor protein, which binds to Contactin-4, normal eye and brain connections did not occur. (nih.gov)
- The gene, CNTNAP2 (contactin-associated protein-like 2) is active in the developing fetus. (nih.gov)
- 1. Contactin 1: An Important and Emerging Oncogenic Protein Promoting Cancer Progression and Metastasis. (nih.gov)
- 12. A complex between contactin-1 and the protein tyrosine phosphatase PTPRZ controls the development of oligodendrocyte precursor cells. (nih.gov)
- From NCBI Gene: The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. (nih.gov)
- Potassium channel associated protein, contactin 2, CNTN2, of 1040 aas and possibly 2 TMSs, at the N- and C-termini. (tcdb.org)
- Although genetic variations in several genes encoding for synaptic adhesion proteins have been found to be associated with autism spectrum disorders, one of the most consistently replicated genes has been CNTNAP2, encoding for contactin-associated protein-like 2 (CASPR2), a multidomain transmembrane protein of the neurexin superfamily. (nih.gov)
- Pre-analytical stability of serum biomarkers for neurological disease: neurofilament-light, glial fibrillary acidic protein and contactin-1. (nih.gov)
- Contactin-associated protein (Caspr) is a major component of the perinodes. (nih.gov)
- Levels of NfL and GFAP were quantified using an HDx analyzer and CNTN1 were quantified using the Human contactin-1 Magnetic Luminex Assay on a Bio-PlexTM 200 system. (nih.gov)
- Phoenix Contactin keskeytymättömät teholähteet AC-sovelluksiin tuottavat lähdössä puhtaan sinikäyrän. (phoenixcontact.com)
- Phoenix Contactin uuden CONTACTRON pro -tuotesarjan tuotteet sallivat yksinkertaisen turvallisuusintegraation ja ovat modulaarisesti laajennettavissa. (phoenixcontact.com)
- They found that those cells in the accessory optic system express (turn on) the Contactin-4 gene at the time that the system is developing. (nih.gov)
- Using a mouse model with a mutated Contactin-4 gene, they showed that Contactin-4's function is very specific to direction-selective RGCs. (nih.gov)
- 8. The gene encoding the mouse contactin-1 axonal glycoprotein is regulated by the collier/Olf1/EBF family early B-Cell factor 2 transcription factor. (nih.gov)
- This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. (nih.gov)
- Recently, studies identified a subgroup of patients with CIDP who were positive for IgG4 autoantibodies against paranodal proteins, such as neurofascin-155 and contactin-1, who respond poorly to first-line therapies for typical CIDP, including intravenous immunoglobulin therapy. (researchprotocols.org)
- We first demonstrate that the Ig superfamily molecule contactin is associated in oligodendrocytes with integrins, extracellular matrix receptors that regulate target-dependent survival by amplification of growth factor signaling. (ed.ac.uk)
- This amplification is inhibited by small interfering RNA-mediated knockdown of contactin in oligodendrocytes. (ed.ac.uk)
- 13. Significances of contactin-1 expression in human gastric cancer and knockdown of contactin-1 expression inhibits invasion and metastasis of MKN45 gastric cancer cells. (nih.gov)
- Caspr1 interacts with Contactins and Nogo-A at the paranodal junction and inhibits the binding of Contactin to glial cell Neurofascin. (rndsystems.com)
- We conclude, therefore, that a novel integrin/contactin complex coordinates signals from extracellular matrix and the axonal surface to regulate both oligodendrocyte survival and myelination by controlling Fyn activity. (ed.ac.uk)
- 20. F3/Contactin promotes hippocampal neurogenesis, synaptic plasticity, and memory in adult mice. (nih.gov)
- Contactins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
- 6. Contactin 1 as a potential biomarker promotes cell proliferation and invasion in thyroid cancer. (nih.gov)
- 10. A spontaneous mutation in contactin 1 in the mouse. (nih.gov)
- This graph shows the total number of publications written about "Contactins" by people in this website by year, and whether "Contactins" was a major or minor topic of these publications. (ucdenver.edu)
- An integrin-contactin complex regulates CNS myelination by differential Fyn phosphorylation. (ed.ac.uk)
- 7. The Role of Contactin 1 in Cancers: What We Know So Far. (nih.gov)
- Huberman and his team labeled specific target groups of neurons in the accessory optic system and then stained sections of the tissue with an antibody specific for Contactin-4. (nih.gov)
- In those mice with mutated Contactin-4, the direction-selective RGCs in the eye didn't talk to the brain correctly. (nih.gov)
- 5. Overexpression of Contactin 1 promotes growth, migration and invasion in Hs578T breast cancer cells. (nih.gov)
- Below are the most recent publications written about "Contactins" by people in Profiles. (ucdenver.edu)