Cell Adhesion Molecules, Neuronal
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
NAV1.2 Voltage-Gated Sodium Channel
A voltage-gated sodium channel subtype that mediates the sodium ion permeability of excitable membranes. Defects in the SCN2A gene which codes for the alpha subunit of this sodium channel are associated with benign familial infantile seizures type 3, and early infantile epileptic encephalopathy type 11.
Hexameric extracellular matrix glycoprotein transiently expressed in many developing organs and often re-expressed in tumors. It is present in the central and peripheral nervous systems as well as in smooth muscle and tendons. (From Kreis & Vale, Guidebook to the Extracellular Matrix and Adhesion Proteins, 1993, p93)
Receptor-Like Protein Tyrosine Phosphatases, Class 5
NAV1.3 Voltage-Gated Sodium Channel
In tissue culture, hairlike projections of neurons stimulated by growth factors and other molecules. These projections may go on to form a branched tree of dendrites or a single axon or they may be reabsorbed at a later stage of development. "Neurite" may refer to any filamentous or pointed outgrowth of an embryonal or tissue-culture neural cell.
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
A compound that contains a reduced purine ring system but is not biosynthetically related to the purine alkaloids. It is a poison found in certain edible mollusks at certain times; elaborated by GONYAULAX and consumed by mollusks, fishes, etc. without ill effects. It is neurotoxic and causes RESPIRATORY PARALYSIS and other effects in MAMMALS, known as paralytic SHELLFISH poisoning.
Nerve Fibers, Myelinated
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Cell Adhesion Molecules
Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.
A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
Immunoglobulin Fc Fragments
Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
Sodium Channel Blockers
Protein Tyrosine Phosphatases
Recombinant Fusion Proteins
Gene Expression Regulation, Developmental
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
Receptors, Cell Surface
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN repeats in their cytoplasmic domains. The cytoplasmic domain of notch receptors is released upon ligand binding and translocates to the CELL NUCLEUS where it acts as transcription factor.
Selective alterations in biosynthetic and endocytic protein traffic in Madin-Darby canine kidney epithelial cells expressing mutants of the small GTPase Rac1. (1/25)Madin-Darby canine kidney (MDCK) cells expressing constitutively active Rac1 (Rac1V12) accumulate a large central aggregate of membranes beneath the apical membrane that contains filamentous actin, Rac1V12, rab11, and the resident apical membrane protein GP-135. To examine the roles of Rac1 in membrane traffic and the formation of this aggregate, we analyzed endocytic and biosynthetic trafficking pathways in MDCK cells expressing Rac1V12 and dominant inactive Rac1 (Rac1N17). Rac1V12 expression decreased the rates of apical and basolateral endocytosis, whereas Rac1N17 expression increased those rates from both membrane domains. Basolateral-to-apical transcytosis of immunoglobulin A (IgA) (a ligand for the polymeric immunoglobulin receptor [pIgR]), apical recycling of pIgR-IgA, and accumulation of newly synthesized GP-135 at the apical plasma membrane were all decreased in cells expressing Rac1V12. These effects of Rac1V12 on trafficking pathways to the apical membrane were the result of the delivery and trapping of these proteins in the central aggregate. In contrast to abnormalities in apical trafficking events, basolateral recycling of transferrin, degradation of EGF internalized from the basolateral membrane, and delivery of newly synthesized pIgR from the Golgi to the basolateral membrane were all relatively unaffected by Rac1V12 expression. Rac1N17 expression had little or no effect on these postendocytic or biosynthetic trafficking pathways. These results show that in polarized MDCK cells activated Rac1 may regulate the rate of endocytosis from both membrane domains and that expression of dominant active Rac1V12 specifically alters postendocytic and biosynthetic membrane traffic directed to the apical, but not the basolateral, membrane. (+info)
Transgenic mice expressing F3/contactin from the TAG-1 promoter exhibit developmentally regulated changes in the differentiation of cerebellar neurons. (2/25)F3/contactin (CNTN1) and TAG-1 (CNTN2) are closely related axonal glycoproteins that are differentially regulated during development. In the cerebellar cortex TAG-1 is expressed first as granule cell progenitors differentiate in the premigratory zone of the external germinal layer. However, as these cells begin radial migration, TAG-1 is replaced by F3/contactin. To address the significance of this differential regulation, we have generated transgenic mice in which F3/contactin expression is driven by TAG-1 gene regulatory sequences, which results in premature expression of F3/contactin in granule cells. These animals (TAG/F3 mice) display a developmentally regulated cerebellar phenotype in which the size of the cerebellum is markedly reduced during the first two postnatal weeks but subsequently recovers. This is due in part to a reduction in the number of granule cells, most evident in the external germinal layer at postnatal day 3 and in the inner granular layer between postnatal days 8 and 11. The reduction in granule cell number is accompanied by a decrease in precursor granule cell proliferation at postnatal day 3, followed by an increase in the number of cycling cells at postnatal day 8. In the same developmental window the size of the molecular layer is markedly reduced and Purkinje cell dendrites fail to elaborate normally. These data are consistent with a model in which deployment of F3/contactin on granule cells affects proliferation and differentiation of these neurons as well as the differentiation of their synaptic partners, the Purkinje cells. Together, these findings indicate that precise spatio-temporal regulation of TAG-1 and F3/contactin expression is critical for normal cerebellar morphogenesis. (+info)
Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma. (3/25)Numerous genetic changes are associated with cancer cell metastasis and invasion. In search for key regulators of invasion and metastasis, a panel of lung cancer cell lines with different invasive ability was screened. The gene for contactin-1 was found to play an essential role in tumor invasion and metastasis. Suppression of contactin-1 expression abolished the ability of lung adenocarcinoma cells to invade Matrigel in vitro as well as the polymerization of filamentous-actin and the formation of focal adhesion structures. Furthermore, knockdown of contactin-1 resulted in extensive inhibition of tumor metastasis and in increased survival in an animal model. RhoA but not Cdc42 or Rac1 was found to serve a critical role in contactin-1-mediated invasion and metastasis. Contactin-1-specific RNA interference resulted in loss of metastatic and invasive capacity in both in vitro and in vivo models. This loss was overturned by constitutive expression of the active form of RhoA. Contactin-1 was differentially expressed in tumor tissues, and its expression correlated with tumor stage, lymph node metastasis, and patient survival. Contactin-1 is proposed to function importantly in the invasion and metastasis of lung adenocarcinoma cells via RhoA-mediated mechanisms. (+info)
The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. (4/25)Flt-4, a VEGF receptor, is activated by its specific ligand, VEGF-C. The resultant signaling pathway promotes angiogenesis and/or lymphangiogenesis. This report provides evidence that the VEGF-C/Flt-4 axis enhances cancer cell mobility and invasiveness and contributes to the promotion of cancer cell metastasis. VEGF-C/Flt-4-mediated invasion and metastasis of cancer cells were found to require upregulation of the neural cell adhesion molecule contactin-1 through activation of the Src-p38 MAPK-C/EBP-dependent pathway. Examination of tumor tissues from various types of cancers revealed high levels of Flt-4 and VEGF-C expression that correlated closely with clinical metastasis and patient survival. The VEGF-C/Flt-4 axis, through upregulation of contactin-1, may regulate the invasive capacity in different types of cancer cells. (+info)
Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin. (5/25)Post-Golgi to apical surface delivery in polarized epithelial cells requires the cytoplasmic dynein motor complex. However, the nature of dynein-cargo interactions and their underlying regulation are largely unknown. Previous studies have shown that the apical surface targeting of rhodopsin requires the dynein light chain, Tctex-1, which binds directly to both dynein intermediate chain (IC) and rhodopsin. In this report, we show that the S82E mutant of Tctex-1, which mimics Tctex-1 phosphorylated at serine 82, has a reduced affinity for dynein IC but not for rhodopsin. Velocity sedimentation experiments further suggest that S82E is not incorporated into the dynein complex. The dominant-negative effect of S82E causes rhodopsin mislocalization in polarized Madin-Darby canine kidney (MDCK) cells. The S82A mutant, which mimics dephosphorylated Tctex-1, can be incorporated into dynein complex but is impaired in its release. Expression of S82A also causes disruption of the apical localization of rhodopsin in MDCK cells. Taken together, these results suggest that the dynein complex disassembles to release cargo due to the specific phosphorylation of Tctex-1 at the S82 residue and that this process is critical for the apical delivery of membrane cargoes. (+info)
Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. (6/25)(+info)
Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E. (7/25)(+info)
The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. (8/25)(+info)
... , also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene. The protein encoded by this gene ... "Entrez Gene: CNTN1 contactin 1". Sakurai T, Lustig M, Nativ M, Hemperly JJ, Schlessinger J, Peles E, Grumet M (Feb 1997). " ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ...
Contactin-3 is a protein that in humans is encoded by the CNTN3 gene. GRCh38: Ensembl release 89: ENSG00000113805 - Ensembl, ... "Entrez Gene: CNTN3 contactin 3 (plasmacytoma associated)". Human CNTN3 genome location and CNTN3 gene details page in the UCSC ... 2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression ... 69 (1): 113-9. doi:10.1006/geno.2000.6310. PMID 11013081. Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the ...
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the ... The subgroup consists of six members now referred to as contactin 1-6, but historically they had different names as shown in ... "Contactins". Cell Adh Migr. 3 (1): 64-70. PMC 2675151. PMID 19262165. This set index page lists chemical compounds articles ... the table below: Shimoda, Yasushi; Watanabe, Kazutada (1 January 2009). " ...
Contactin-2 is a protein that in humans is encoded by the CNTN2 gene. The protein encoded by this gene is a member of the ... "Entrez Gene: CNTN2 contactin 2 (axonal)". Traka M, Goutebroze L, Denisenko N, Bessa M, Nifli A, Havaki S, Iwakura Y, Fukamauchi ... 211 (1-2): 329-39. doi:10.1111/j.1432-1033.1993.tb19902.x. PMID 8425542. Kozlov SV, Giger RJ, Hasler T, Korvatska E, Schorderet ... 215 (1): 133-41. doi:10.1111/j.1432-1033.1993.tb18015.x. PMID 8344273. Hasler TH, Rader C, Stoeckli ET, Zuellig RA, Sonderegger ...
Contactin-4 is a protein that in humans is encoded by the CNTN4 gene. The protein encoded by this gene is a member of the ... 2006). "The contactin 4 gene locus at 3p26 is a candidate gene of SCA16". Neurology. 67 (7): 1236-41. doi:10.1212/01.wnl. ... "Entrez Gene: CNTN4 contactin 4". "Gene for brain connections linked with autism". www.newsdaily.com. Archived from the original ... 2004). "Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome". Am. J. ...
Node of Ranvier
... such as tenascin R and the cell-adhesion molecules neurofascin and contactin. Contactin is also present at nodes in the CNS and ... At CNS nodes, the axonal proteins also include contactin; however, Schwann cell microvilli are replaced by astrocyte perinodal ... The size of the nodes span from 1-2 μm whereas the internodes can be up to (and occasionally even greater than)1.5 millimetres ... 30 (1): 105-119. doi:10.1016/S0896-6273(01)00266-5. PMID 11343648. S2CID 10252129. Black, J.A., Sontheimer, H., Oh, Y., and ...
Contactin-associated protein-like 2 is a protein that in humans is encoded by the CNTNAP2 gene. Since the most recent reference ... "Entrez Gene: CNTNAP2 contactin associated protein-like 2". Ashley, Euan A. (16 August 2016). "Towards precision medicine". ... Nakabayashi K, Scherer SW (April 2001). "The human contactin-associated protein-like 2 gene (CNTNAP2) spans over 2 Mb of DNA at ... Overview of all the structural information available in the PDB for UniProt: Q9UHC6 (Contactin-associated protein-like 2) at ...
... members also bind "heterophilically" to members of the contactin or CNTN1 family. L1 family members bind to many ... doi:10.1007/978-1-4614-8090-7_9. ISBN 978-1-4614-8089-1. PMID 25300138. Wei CH, Ryu SE (July 2012). "Homophilic interaction of ... NrCAM and neurofascin both have class 1 PDZ domain binding motifs at their COOH termini. NrCAM can bind to SAP102 and other ...
"Contactin-Associated Protein (Caspr) and Contactin Form a Complex That Is Targeted to the Paranodal Junctions during ... CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 ... The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino ... "Entrez Gene: Contactin associated protein 1". "OMIM Entry- * 602346 - CONTACTIN-ASSOCIATED PROTEIN 1; CNTNAP1". omim.org. ...
Generalized epilepsy with febrile seizures plus
This extracellular region is similar to the cell adhesion molecule contactin and other cell adhesion molecules. It is believed ... GEFS+ type 1 is a subtype of GEFS+ in which there are mutations in SCN1B, a gene encoding a sodium channel β subunit. The β ... 126 (Pt 1): 230-40. doi:10.1093/brain/awg018. PMID 12477709. Harkin L, Bowser D, Dibbens L, Singh R, Phillips F, Wallace R, ... 28 (1): 46-8. doi:10.1038/88254. PMID 11326274. Wallace R, Marini C, Petrou S, Harkin L, Bowser D, Panchal R, Williams D, ...
Contactin, also known as F3 or F11, associates with beta 1 as shown via co-immunoprecipitation. Fibronectin-like (FN-like) ... Shah BS, Rush AM, Liu S, Tyrrell L, Black JA, Dib-Hajj SD, Waxman SG (August 2004). "Contactin associates with sodium channel ... "Contactin associates with Na+ channels and increases their functional expression". The Journal of Neuroscience. 21 (19): 7517- ... 26 (1): 13-25. doi:10.1016/S0896-6273(00)81133-2. PMID 10798388. S2CID 17928749. Isom LL, De Jongh KS, Patton DE, Reber BF, ...
5 had antibodies against Contactin-2 and 18 (19%) had antibodies with unknown specificity. Of the patients with Contactin-2 ... 19 had antibodies reacting with Contactin-associated protein 2 (CASPR 2), ... anti-LGI-1 encephalitis: Patients with anti-LGI1 encephalitis have limbic encephalitis with amnesia and/or confusion (100%) and ... The number of patients with anti-LGI1 antibodies and tumours have been reported to be between 0 and 11% in anti-LGI-1 antibody ...
Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene. This gene product belongs to ... "Entrez Gene: CNTNAP4 contactin associated protein-like 4". Human CNTNAP4 genome location and CNTNAP4 gene details page in the ... 16 (1): 55-65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial ...
Compton-North congenital myopathy
"Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital ...
CEE 7 standard AC plugs and sockets
Schuko is an abbreviation for the German word Schutzkontakt, which means "Protective contact" - in this case "protective" ... CEE 7/1 wall socket, accepts CEE 7/2 (unearthed) plug and also CEE 7/4, CEE 7/6 and CEE 7/7 (earthed) plugs Power bar with CEE ... CEE 7/1 sockets accept CEE 7/4, CEE 7/6 and CEE 7/7 plugs without providing an earth connection. The earthed CEE 7/3 and CEE 7/ ... CEE 7/1 and CEE 7/4 are still occasionally found in less used areas of some older homes, particularly in outbuildings or hot ...
Inflammatory demyelinating diseases of the central nervous system
... contactin associated protein 1 (CASPR1) and gliomedin. All of them nodal and paranodal proteins. Several anti-TNF drugs like ... 60 (1): 27-30. doi:10.1136/jnnp.60.1.27. PMC 486185. PMID 8558146. Li R, Patterson KR, Bar-Or A (July 2018). "Reassessing B ... 12 (1): 46. doi:10.1186/s12974-015-0256-1. PMC 4359547. PMID 25889963. Spadaro M, Gerdes LA, Mayer MC, Ertl-Wagner B, Laurent S ... ISBN 978-1-4160-6068-0. Mihalova T, Kwong JL, Alachkar H (2019-12-01). "214 Analysis of CSF IgG index, IgG synthesis and ...
Chronic inflammatory demyelinating polyneuropathy
Autoantibodies to components of the Ranvier nodes, specially autoantibodies the Contactin-associated protein 1 (CASPR), cause a ... contactin-1 and caspr-1. These cases are special not only because of their pathology, but also because they are non-responsive ... 129 (1): 232-237. doi:10.1016/j.clinph.2017.10.040. PMID 29202391. S2CID 24416887. Goedee, H. Stephan; van der Pol, W. Ludo; ... 115 (1-2): 4-18. doi:10.1016/S0165-5728(01)00266-1. PMC 1073940. PMID 11282149. van Doorn, Pieter A.; Garssen, Marcel P.J. ( ...
Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: ... 69 (1): 113-9. doi:10.1006/geno.2000.6310. PMID 11013081. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. ( ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M (Mar 2004). "Nuclear ... Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene. ADP- ...
Multiple sclerosis research
... contactin 1 (CNTN1), contactin associated protein 1 (CASPR1) and gliomedin. All of them nodal and paranodal proteins. Anti-TNF ... 26 (1): 27-40. doi:10.1111/ene.13819. PMID 30300457. Lublin, F. D.; Reingold, S. C.; Cohen, J. A.; Cutter, G. R.; Sorensen, P. ... 286 (1-2): 99-103. doi:10.1016/j.jns.2009.05.028. PMC 2760629. PMID 19539954. Voskuhl, Rhonda R; Wang, HeJing; Wu, T C Jackson ... 266 (1-2): 25-30. doi:10.1016/j.jns.2007.08.023. PMID 17870094. S2CID 24283817. Krishnan C, Kaplin AI, Brodsky RA, et al. (June ...
Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: ... 36 (1): 69-76. doi:10.1038/ng1276. PMID 14647276. Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, ... 69 (1): 113-9. doi:10.1006/geno.2000.6310. PMID 11013081. Pacheco-Rodriguez G, Moss J, Vaughan M (2002). "BIG1 and BIG2: ... Kuroda F, Moss J, Vaughan M (Feb 2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and ...
Shah BS, Rush AM, Liu S, Tyrrell L, Black JA, Dib-Hajj SD, Waxman SG (August 2004). "Contactin associates with sodium channel ... 264 (1): 113-22. doi:10.1016/S0378-1119(00)00594-1. PMID 11245985. Whitaker WR, Faull RL, Dragunow M, Mee EW, Emson PC, Clare ... 10 (1): 67-70. doi:10.1007/BF02737087. PMID 9589372. S2CID 2533542. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O ( ... 7 (1): 65-73. doi:10.1093/dnares/7.1.65. PMID 10718198. Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, ...
Notch signaling pathway
... such as F3/contactin. In the nematode C. elegans, two genes encode homologous proteins, glp-1 and lin-12. There has been at ... 266 (1): 161-77. doi:10.1016/j.ydbio.2003.10.017. PMID 14729486. Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, Jan LY ... 23 (1): 14-25. doi:10.1128/MCB.23.1.14-25.2003. PMC 140667. PMID 12482957. Grego-Bessa J, Luna-Zurita L, del Monte G, Bolós V, ... Notch 1, for example, has 36 of these repeats. Each EGF-like repeat is composed of approximately 40 amino acids, and its ...
... beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Wang J, Robinson JF, O'Neil CH, et al. (2006). "Ankyrin G overexpression in ... 27 (1): 189-91. doi:10.1006/geno.1995.1023. PMID 7665168. Lambert S, Davis JQ, Bennett V (September 1997). "Morphogenesis of ... 78 (1): 78-88. doi:10.1086/498851. PMC 1380225. PMID 16385451. Stabach PR, Devarajan P, Stankewich MC, et al. (2008). "Ankyrin ...
Gollan L, Salomon D, Salzer JL, Peles E (December 2003). "Caspr regulates the processing of contactin and inhibits its binding ... "Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction". Current Biology. 12 ... 118 (1): 149-61. doi:10.1083/jcb.118.1.149. PMC 2289533. PMID 1377696. Burmeister M, Ren Q, Makris GJ, Samson D, Bennett V ( ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 1, Human proteins, All ...
... as well as the neuronal molecules contactin and Thy-1 (CD90). Alpha toxin can activate the immune sensor NLRP3 in mammalian ... 66 (1): 63-66. doi:10.1016/0002-9343(79)90483-2. PMID 420252. Liechti, ME; Schob, O; Kacl, GM; Caduff, B (2003). "Clostridium ... 4 (4): 1-9. doi:10.1371/journal.ppat.1000045. PMC 2275794. PMID 18404211. Ballard, J; Bryant, A; Stevens, D; Tweten, RK (1992 ... 63 (1): 340-344. doi:10.1128/IAI.63.1.340-344.1995. PMC 172997. PMID 7806374. Melton-Witt, JA; Bensten, LM; Tweten, RK (2006 ...
1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine ... 12 (1): 1-10. doi:10.1017/S1461145708009127. PMID 18664314. Grumet M (1997). "Nr-CAM: a cell adhesion molecule with ligand and ... 154 (1): 187-96. doi:10.1083/jcb.200104038. PMC 2196853. PMID 11449000. Dry K, Kenwrick S, Rosenthal A, Platzer M (2001). "The ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Hutcheson HB, Olson LM, Bradford Y, et al. (2004). "Examination of NRCAM, ...
Leucine-rich, glioma inactivated 1, also known as LGI1, is a protein which in humans is encoded by the LGI1 gene. It may be a ... 10 (1): 56-60. doi:10.1038/ng0595-56. PMC 2823475. PMID 7647791. Wilson MH, Puranam RS, Ottman R, Gilliam C, Limbird LE, George ... 51 (6): 1730-1. doi:10.1212/wnl.51.6.1730. PMID 9855534. S2CID 85601127. Kalachikov S, Evgrafov O, Ross B, Winawer M, Barker- ... "Entrez Gene: LGI1 leucine-rich, glioma inactivated 1". Ottman R, Risch N, Hauser WA, Pedley TA, Lee JH, Barker-Cummings C, ...
... contactin-associated proteins (CNTNAP1, CNTNAP2, CNTNAP3, CNTNAP3B, CNTNAP4, CNTNAP5), some collagens (COL5A1, COL5A3, COL9A1, ... 375 (1): 27-32. doi:10.1016/j.bbrc.2008.07.111. PMID 18675790. Rodin S, Domogatskaya A, Ström S, Hansson EM, Chien KR, Inzunza ... In mouse laminin gamma-1 chain, the seventh LE domain has been shown to be the only one that binds with a high affinity to ... 15 (1): 95-106. doi:10.1016/S0143-4004(05)80240-1. PMID 8208674. Ockleford C, Bright N, Hubbard A, D'Lacey C, Smith J, Gardiner ...
A Pitt-Hopkins-like phenotype has been assigned to autosomal recessive mutations of the contactin associated protein like 2 ( ... 11 (1): 24. doi:10.1186/s11689-019-9282-0. PMC 6778364. PMID 31586495. Whalen S, Héron D, Gaillon T, Moldovan O, Rossi M, ... PTHS is estimated to occur in 1:11,000 to 1:41,000 people. PTHS can be seen as early as childhood. The earliest signs in ... 33 (1): 64-72. doi:10.1002/humu.21639. PMID 22045651. S2CID 9559486. "Pitt-Hopkins syndrome may point the way to autism ...
Contactin 4 COL7A1: Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) CRBN: Cereblon ... ISBN 978-1-136-84407-2. Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last ... ISBN 978-1-4673-1921-8. S2CID 16666470. "p": Short arm; "q": Long arm. For cytogenetic banding nomenclature, see article locus ... Partial list of the genes located on p-arm (short arm) of human chromosome 3: ALAS1: aminolevulinate, delta-, synthase 1 APEH: ...
Andrew D. Huberman
"Contactin-4 mediates axon-target specificity and functional development of the accessory optic system". Neuron. 86 (4): 985-999 ... "Huberman Lab, the #1 Health & Fitness Podcast, Teams Up with Supercast to Launch Paid Subscription". podnews.net. 2022-10-02. ... 31 (1): 479-509. doi:10.1146/annurev.neuro.31.060407.125533. PMC 2655105. PMID 18558864. Huberman, Andrew D; Murray, Karl D; ... The podcast is frequently ranked in the top 15 of all podcasts globally and is consistently ranked #1 in the categories of ...
Heritability of autism
January 2008). "Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum ... 40 (1): 4e-4. doi:10.1136/jmg.40.1.e4. PMC 1735256. PMID 12525552. Auranen M, Varilo T, Alen R, Vanhala R, Ayers K, Kempas E, ... 87 (1): 75-83. doi:10.1016/j.ygeno.2005.09.008. PMID 16311013. Skaar DA, Shao Y, Haines JL, Stenger JE, Jaworski J, Martin ER, ... 129B (1): 76-81. doi:10.1002/ajmg.b.30011. PMID 15274045. S2CID 31012683. Ronald A, Happé F, Bolton P, Butcher LM, Price TS, ...
Czech Brain Ageing Study
... neurogranin and contactin-2. The CBAS team is well established and internationally recognized, and has multiple international ... Brain-computer interface Neurology Andel R (1 December 2014). "Aging in the Czech republic". The Gerontologist. 54 (6): 893-900 ...
CASPR2 and Contactin-2 in CNS diseases. She demonstrated that transfer of antibodies across the placenta from the pregnant ... Retrieved 1 July 2010. "Prizes awarded by the British Neuroscience Association , The British Neuroscience Association". www.bna ...
Since his performance material often involves themes of mortality and spirit contact-in addition to demonstrations of telepathy ... wgntv-morning-news-1 Houdini's Halloween[permanent dead link] from WGN-TV and Red Eye, October 28, 2005 His Magic Helps Kids ...
... beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ... Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene. Voltage-gated sodium channels are ... 148 (1): 164-74. doi:10.1016/j.neuroscience.2007.05.038. PMID 17629415. S2CID 36136731. GeneReviews/NIH/NCBI/UW entry on ... Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone ...
... beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ... 81 (1-2): 187-90. doi:10.1016/S0169-328X(00)00145-5. PMID 11000491. Kasai N, Fukushima K, Ueki Y, et al. (2001). "Genomic ... 303 (1): 53-8. doi:10.1016/0014-5793(92)80476-W. PMID 1317301. S2CID 29330026. Ahmed CM, Ware DH, Lee SC, et al. (1992). " ... 264 (1): 113-22. doi:10.1016/S0378-1119(00)00594-1. PMID 11245985. Malacarne M, Gennaro E, Madia F, et al. (2001). "Benign ...
In order to form a paranodal junction, Caspr and contactin form a complex with neurofascin 155. It has been shown that ... neurofascin 155 protein clusters then bring Caspr and contactin into the membrane to form the complex, which allows the ... The binding of gp120 to GalCer has the ability to start the fusion of HIV-1, but the binding of gp120 to sulfatide does not. ... There are two types of cell subtypes that interact with CD1d cells: Type 1 Natural killer T cells and Type 2 Natural killer T ...
Faivre-Sarrailh C, Banerjee S, Li J, Hortsch M, Laval M, Bhat MA (October 2004). "Drosophila contactin, a homolog of vertebrate ... 131 (1): 181-190. doi:10.1242/dev.00917. ISSN 0950-1991. PMID 14681183. Dubey, Pankaj; Kapoor, Tushna; Gupta, Samir; Shirolikar ... contactin, is required for septate junction organization and paracellular barrier function". Development. 131 (20): 4931-42. ...
contactin-1 isoform 2 precursor [Homo sapiens] - Protein - NCBI
contactin-1 isoform 2 precursor [Homo sapiens] contactin-1 isoform 2 precursor [Homo sapiens]. gi,28373119,ref,NP_778203.1, ... LSBio CNTN1 / gp135 / Contactin 1 Proteins [LifeSpan BioSciences, Inc.] LSBio CNTN1 / gp135 / Contactin 1 Proteins. LifeSpan ... Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis. [PLoS One. 2023] Contactin-1 links autoimmune ... Neurofilament-light and contactin-1 association with long-term brain atrophy in natalizumab-treated relapsing-remitting ...
Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated...
Of the 19 patients with contactin-associated protein-antibody-2, 10 had neuromyotonia or Morvans syndrome, compared with only ... to contactin-associated protein-2 in 19 sera, to leucine-rich, glioma inactivated 1 protein in 55 sera and to contactin-2 in ... who all had contactin-associated-2 protein antibodies. This study confirms that the majority of patients with high potassium ... detection of contactin-associated protein-2 antibodies should help identify the risk of an underlying tumour and a poor ...
NIMH » Contactin
Contactin -- RDoC Element. Type of Element: Molecule. The following construct(s)/subconstruct(s) refer to this element.... * ... Home , Research , Research Funded by NIMH , Research Domain Criteria (RDoC) , Units of Analysis , Molecules , Contactin. ... Phone: 1-866-615-6464 Live Online Chat: Talk to a representative Email: [email protected] Hours: 8:30 a.m. - 5 p.m. ET, M-F ...
Leucine-Rich Glioma-Inactivated 1 versus Contactin-Associated Protein-like 2 Antibody Neuropathic Pain: Clinical and Biological...
... and contactin-associated protein-like 2 (CASPR2) antibodies. Of 147 patients with these autoantibodies, pain was experienced by ... Pain is a under-recognized association of leucine-rich glioma-inactivated 1 (LGI1) ... Leucine-Rich Glioma-Inactivated 1 versus Contactin-Associated Protein-like 2 Antibody Neuropathic Pain: Clinical and Biological ...
Association of Cell Adhesion Molecules Contactin-6 and Latrophilin-1 Regulates Neuronal Apoptosis
In view of important neurobiological functions of the cell adhesion molecule contactin-6 (Cntn6) that have emerged from studies ... Association of Cell Adhesion Molecules Contactin-6 and Latrophilin-1 Regulates Neuronal Apoptosis. DSpace/Manakin Repository. ... We identified the cell adhesion GPCR latrophilin-1 (Lphn1, a.k.a. CIRL1/CL, ... read more ADGRL1) as a binding partner for ...
Molecular glue that binds cells in the nervous system shows up in advanced imaging - News - Utrecht University
Publications - Maria Laura Allende, Ph.D. - NIDDK
Phone: +1-800-860-8747 TTY: +711 Chat. Live Chat Available. 8:30 a.m - 5 p.m. ET. Monday - Friday ... Sphingosine-1-phosphate receptors and the development of the vascular system.. Allende ML, Proia RL.. Biochim Biophys Acta ( ... Sphingosine 1-phosphate lyase deficiency disrupts lipid homeostasis in liver.. Bektas M, Allende ML, Lee BG, Chen W, Amar MJ, ... Sphingosine-1-phosphate regulation of mammalian development.. Kono M, Allende ML, Proia RL.. Biochim Biophys Acta (2008 Sep) ...
Moraal B[au] - Search Results - PubMed
Serum contactin-1 as a biomarker of long-term disease progression in natalizumab-treated multiple sclerosis. van Lierop ZY, ... Neurofilament-light and contactin-1 association with long-term brain atrophy in natalizumab-treated relapsing-remitting ... 2020 Oct 20;1(7):100101. doi: 10.1016/j.xcrm.2020.100101. Cell Rep Med. 2020. PMID: 33103128 Free PMC article. ... 2022 Jan;28(1):102-110. doi: 10.1177/13524585211010097. Epub 2021 Apr 23. Mult Scler. 2022. PMID: 33890520 Free PMC article. ...
6. Contactin 1 as a potential biomarker promotes cell proliferation and invasion in thyroid cancer.. Shi K; Xu D; Yang C; Wang ... 5. Overexpression of Contactin 1 promotes growth, migration and invasion in Hs578T breast cancer cells.. Chen N; He S; Geng J; ... 7. The Role of Contactin 1 in Cancers: What We Know So Far.. Liang Y; Ma C; Li F; Nie G; Zhang H. Front Oncol; 2020; 10(): ... F3/Contactin acts as a modulator of neurogenesis during cerebral cortex development.. Bizzoca A; Corsi P; Polizzi A; Pinto MF; ...
Tissue expression of PMP2 - Summary - The Human Protein Atlas
Contactin 2. 0.9667. 70. GPR37L1. G protein-coupled receptor 37 like 1. 0.9667. 70. ... A confidence of 1 indicates that the gene was assigned to this cluster in all repeated clusterings. ... The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates ... where 1 is the highest possible confidence. The clustering results are shown in a UMAP, where the cluster this gene was ...
Contactins [D12.776.395.522.214.171.1245] * Contactin 1 [D12.776.395.5126.96.36.1995.100] * Contactin 2 [D12.776.395.550.200.250 ... Contactins [D12.776.543.5188.8.131.525] * Contactin 1 [D12.776.543.5184.108.40.2065.100] * Contactin 2 [D12.776.543.550.200.250 ... Contactin 1 Preferred Term Term UI T769510. Date04/15/2010. LexicalTag NON. ThesaurusID NLM (2011). ... Contactin 1 Preferred Concept UI. M0545553. Registry Number. 0. Scope Note. A contactin subtype that is predominantly expressed ...
Publications | Max Planck Institute
Contactin-associated protein-like 2 (CNTNAP2) gene encodes for CASPR2, a presynaptic type 1 transmembrane protein, involved in ... Genotype-phenotype correlation in contactin-associated protein-like 2 (CNTNAP-2) developmental disorder. Human Genetics. ... Displaying 1 - 100 of 8897 * Arana, S., Hagoort, P., Schoffelen, J.-M., & Rabovsky, M. (in press). Perceived similarity as a ... Group 1 heard Talker 1 use only F0 to signal stress (intensity and duration values were ambiguous), while Talker 2 used only ...
Frontiers | Stereotactically Injected Kv1.2 and CASPR2 Antisera Cause Differential Effects on CA1 Synaptic and Cellular...
... the pathophysiological role of this antibody in comparison to an antibody against the VGKC-associated protein contactin- ... the pathophysiological role of this antibody in comparison to an antibody against the VGKC-associated protein contactin- ... and contactin-associated protein-2 (CASPR2) (Lai et al., 2010; Irani et al., 2010). Recently, a large series of sera with VGKC ... Timo Kirschstein1,2,3*†, Erika Sadkiewicz1†, Gerda Hund-Göschel1†, Juliane Becker1, Xiati Guli1, Steffen Müller1, Marco Rohde1 ...
New Estimates of Incidence of Encephalitis in England - Volume 19, Number 9-September 2013 - Emerging Infectious Diseases...
Julia Granerod1. , Simon Cousens, Nicholas W.S. Davies1, Natasha S. Crowcroft1, and Sara L. Thomas ... 1On behalf of the United Kingdom Public Health England Aetiology of Encephalitis Study Group (members listed at the end of this ... Table 1. Definition of numerator for encephalitis incidence estimates, England * Table 2. Characteristics of HES-only ... For the defined 1-year period, the overall number of incident encephalitis admissions recorded in the relevant HES trusts was ...
Contactin_Associated_Protein-1,modify,22-AUG-08,(null),(null) C26478,CD94_Antigen,modify,22-AUG-08,(null),(null) C33529,Seminal ... 1_Protein,modify,22-AUG-08,(null),(null) C25777,C-C_Motif_Chemokine_Receptor-5,modify,22-AUG-08,(null),(null) C25778,C-C_Motif_ ... Alpha-1_II_Chain,create,22-AUG-08,(null),(null) C51459,GPR54_wt_Allele,modify,22-AUG-08,(null),(null) C29643,G_Protein-Coupled_ ... 1,create,22-AUG-08,(null),(null) C67518,Web_Site,modify,22-AUG-08,(null),(null) C19467,Home_Page,modify,22-AUG-08,(null),(null ...
Contactins [D09.400.430.8220.127.116.115] * Contactin 1 [D09.400.430.818.104.22.1685.100] * Contactin 2 [D09.400.430.890.200.250 ... Contactins [D12.776.395.522.214.171.1245] * Contactin 1 [D12.776.395.5126.96.36.1995.100] * Contactin 2 [D12.776.395.550.200.250 ... Contactins [D12.776.543.5188.8.131.525] * Contactin 1 [D12.776.543.5184.108.40.2065.100] * Contactin 2 [D12.776.543.550.200.250 ... Contactin 1 Preferred Term Term UI T769510. Date04/15/2010. LexicalTag NON. ThesaurusID NLM (2011). ...
Joana Ferreira (0E15-84D6-0BF4) | CIÊNCIAVITAE
"Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of a-amino-3-hydroxy-5-methyl-4- ... Hell J: F1000Prime Recommendation of [Kellermayer B et al., Neuron 2018 100(1):106-119.e7] F1000 Research Ltd, Reino Unido ... She has supervised several students (2 master students from the University of Bordeaux, 1 from the University of Bialystok, ... Jury member in project evaluation of Bordeaux International Neuroscience Master 1 and 2, University of Bordeaux, France. ...
Human Neurocan Antibody AF6508: R&D Systems
We found Websites Listing below when search with tsjessyca.contactin.bio on Search Engine. Ts Jessyca. Onlyfans. Whatsapp. ... Email address with tsjessyca.contactin.bio Found 0 emails of this domain. ... Content on ContactInBio.com and ContactIn.Bio including images and text are copyrighted. Any use of material is possible only ... We offer 4 urls to choose as yourusername.ctcin.bio, yourusername.contactin.bio, yourusername.contactinbio.com or allmy.link/ ...
Contact - IN THE LIGHT PERFORMING ARTS CENTER
ToxOut™ Endotoxin-Free Protein A Sepharose | M1300-1 | Biovision
Biomolecule/Target: CNTN2/Contactin-2Synonyms: CNTN2, CNTN-2, AXT, DKFZp781D102, FLJ37193, FLJ42746, MGC157722, TAG-1, TAG1, ... Kidney Injury Molecule-1 (KIM-1, HAVCR1) is a class I integral membrane glycoprotein that belongs to the TIM family of proteins ... Biomolecule/Target: N/ASynonyms: Ephrin A1; LERK1; EFL1; B61; EPH-Related Receptor Tyrosine Kinase Ligand 1; TNF Alpha-Induced ...
Bastiaan Moraal - Research output - Amsterdam UMC research portal
Serum contactin-1 as a biomarker of long-term disease progression in natalizumab-treated multiple sclerosis. van Lierop, Z. Y. ... Neurofilament-light and contactin-1 association with long-term brain atrophy in natalizumab-treated relapsing-remitting ... van Faals, N. L., Dekker, I., Balk, L. J., Moraal, B., Barkhof, F., Uitdehaag, B. M. J., Killestein, J. & Wattjes, M. P., 1 Nov ... 1, p. 33-42 10 p.. Research output: Contribution to journal › Erratum/Corrigendum › Academic › peer-review ...
Contactin 1 - Preferred Concept UI. M0545553. Scope note. A contactin subtype that is predominantly expressed in the CEREBELLUM ... A contactin subtype that is predominantly expressed in the CEREBELLUM; HIPPOCAMPUS; NEOCORTEX; and HYPOTHALAMUS.. ... contactina 1. Scope note:. Subtipo de contactina que se expresa de modo predominante en el CEREBELO, HIPOCAMPO, NEOCÓRTEX e ...
contactin-associated protein 1 precursor. Cntnap1. 1381. 153822. catechol O-methyltransferase. Comt. 264. 29466. ... inositol 1,4,5-trisphosphate receptor type 2. Itpr2. 2701. 306929. inositol 1,4,5-trisphosphate receptor type 3. Itpr3. 2670. ... intercellular adhesion molecule 1 precursor. Icam1. 545. 57418. insulin-like growth factor 1 receptor precursor. Igf1r. 1370. ... alpha-1,3/1,6-mannosyltransferase ALG2. Alg2. 415. 47274. alkaline phosphatase, tissue-nonspecific isozyme precursor. Alpl. 524 ...
Search Results for elisa kit - arigo Biolaboratories
Gene Set - ChIP K27me3 17603471 mouseNPC
contactin 2 (axonal) COBL cordon-bleu WH2 repeat protein COCH cochlin COL13A1 collagen, type XIII, alpha 1 ... HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1 HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ... potassium channel, voltage gated KQT-like subfamily Q, member 1 KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, ... potassium channel, voltage gated eag related subfamily H, member 1 KCNH3 potassium channel, voltage gated eag related subfamily ...
Supplementary Materials Data Supplement supp 77 2 179 index. affect kids and adults, are protracted - Current development of...
... contactin-associated protein-like 2; FLAIR = fluid-attenuated Imiquimod cost inversion recovery; GABAB-R = -aminobutyric acid-B ... 1) the epitopes are extracellular; 2) the antibody binding is seen in cells transfected with the mark antigen; 3) for all your ... receptor; GAD65 = glutamic acidity decarboxylase 65; LGI1 = leucine-rich glioma-inactivated 1; MuSK = muscle-specific kinase; ... figure 1). These scholarly research uncovered subsets of. ...
HPR105-02/2540002581 LINDE HPR HYDRAULIC PUMP - BOSCH REXROTH A7VO VARIABLE DISPLACEMENT PUMPS MANUFACTURER
base width:2.5800 in; base height:1.2500 in; expansion type:Non-Expansion Bearin; seal type:Triple-lip contactin; manufacturer ... e:0.32; outer rb:1.5; DA1:7.348; Calculation factor (Y0):1; Basic static load rating (C0):37 kN; RAr:105.28; DA2:6.445; a:12,9 ... 1-1/2 in; material specification:Oilite®, Synthet; D:1/2 in; sleeve bearing type:Plain Sleeve; d:5/16 in; groove/plug type:None ... 1-1/4-12; lubrication hole location:Stud Side; stud type:Eccentric; roller shape:Flat; stud diameter:1.2500 in; head type:Hex; ...
- Leucine-Rich Glioma-Inactivated 1 versus Contactin-Associated Protein-like 2 Antibody Neuropathic Pain: Clinical and Biological Comparisons. (bvsalud.org)
- Pain is a under-recognized association of leucine -rich glioma -inactivated 1 (LGI1) and contactin-associated protein -like 2 (CASPR2) antibodies . (bvsalud.org)
- 26. Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS. (nih.gov)
- 36. Antibodies to neurofascin, contactin-1, and contactin-associated protein 1 in CIDP: Clinical relevance of IgG isotype. (nih.gov)
- We aimed to characterize the pathophysiological role of this antibody in comparison to an antibody against the VGKC-associated protein contactin-associated protein-2 (CASPR2). (frontiersin.org)
- adaptor related protein complex 1 subun. (gsea-msigdb.org)
- BCL2 interacting protein 1 [Source:HGNC. (gsea-msigdb.org)
- METHODS: In this phase 3, multicentre, randomised, double-blind, placebo-controlled trial, adult patients (aged ≥18 years) with primary IgA nephropathy, estimated glomerular filtration rate (eGFR) 35-90 mL/min per 1·73 m2, and persistent proteinuria (urine protein-creatinine ratio ≥0·8 g/g or proteinuria ≥1 g/24 h) despite optimised renin-angiotensin system blockade were enrolled at 132 hospital-based clinical sites in 20 countries worldwide. (bvsalud.org)
- Genotype-phenotype correlation in contactin-associated protein-like 2 (CNTNAP-2) developmental disorder. (cdc.gov)
- Fas antigen, also termed APO-1 or CD95, is a transmembrane protein and a member of the tumor necrosis factor receptor/nerve growth factor receptor superfamily which mediates apoptosis upon oligomerization. (nih.gov)
- KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis. (nih.gov)
- From parallel screens of human fetal brain and HeLa cDNA libraries, we obtained multiple independent isolates of human integrin cytoplasmic domain-associated protein-1 (ICAP-1) as interacting clones. (nih.gov)
- The alpha isoform of ICAP-1 is a 200 amino acid serine/threonine-rich phosphoprotein which binds the cytoplasmic tail of beta1 integrins. (nih.gov)
- In view of important neurobiological functions of the cell adhesion molecule contactin-6 (Cntn6) that have emerged from studies on null-mutant mice and autism spectrum disorders patients, we set out to examine pathways underlying functions of Cntn6 using a proteomics approach. (uu.nl)
- 32. Effect of low-dose rituximab treatment on autoimmune nodopathy with anti-contactin 1 antibody. (nih.gov)
- Contactin-1 links autoimmune neuropathy and membranous glomerulonephritis. (nih.gov)
- Wilson 1998) and the kisspeptins (Kp), a family of neuropeptide products of the KiSS-1 gene (Navarro et al. (nih.gov)
- Sphingosine kinase 1 and sphingosine-1-phosphate receptor 2 are vital to recovery from anaphylactic shock in mice. (nih.gov)
- 24. MicroRNA-200c-targeted contactin 1 facilitates the replication of influenza A virus by accelerating the degradation of MAVS. (nih.gov)
- Sphingosine-1-phosphate can promote mast cell hyper-reactivity through regulation of contactin-4 expression. (nih.gov)
- 22. Expanding the Ig superfamily code for laminar specificity in retina: expression and role of contactins. (nih.gov)
- 1. Decreased expression levels of ELOVL6 indicate poor prognosis in hepatocellular carcinoma. (nih.gov)
- 19. Expression and prognostic significance of contactin 1 in human hepatocellular carcinoma. (nih.gov)
- Kidney Injury Molecule-1 (KIM-1, HAVCR1) is a class I integral membrane glycoprotein that belongs to the TIM family of proteins. (transcriptionfactor.org)
- We show that mutagenesis of the N-terminal KRIT1 NPXY amino acid sequence, a motif critical for ICAP-1 binding to beta1 integrin molecules, completely abrogates the KRIT1/ICAP-1 interaction. (nih.gov)
- Samples (1 x10(6) cells/ml) from irradiated and non-irradiated cells of each cell line were incubated with or without 5 microg/ml of Fas ligand peptide for 2 h at 37 degrees C in a humidified atmosphere of 5% carbon dioxide (CO2) in air. (nih.gov)
- The interaction of KRIT1 and ICAP-1 was confirmed by GST-KRIT1 trapping of endogenous ICAP-1 from 293T cells. (nih.gov)
- Neurocan inhibits neuronal adhesion and neurite outgrowth through interactions with a variety of matrix and transmembrane molecules including NCAM-L1, NCAM-1, Syndecan-3, Glypican-1, Tenascin, Contactin-2/TAG1, and HAPLN1 (1, 6, 10-15). (rndsystems.com)
- The examination of kidney biopsies has consistently shown glomerular deposition of mannan-binding lectin (1 of 6 pattern-recognition molecules that activate the lectin pathway) together with IgA1 in up to 50% of patients with IgAN. (bvsalud.org)
- The interaction between ICAP-1 and KRIT1, and the presence of a FERM domain in the latter, suggest that KRIT1 might be involved in the bidirectional signaling between integrin molecules and the cytoskeleton. (nih.gov)
- Neurofilament-light and contactin-1 association with long-term brain atrophy in natalizumab-treated relapsing-remitting multiple sclerosis. (nih.gov)
- For example, 2 separate records and hence to patients admitted from November 1, 2006, through Oc- episodes are generated in Hospital Episode Statistics (HES) tober 31, 2007, when all 24 hospitals in the PHE study were if a patient is initially admitted to Accident and Emergency recruiting simultaneously, and to the 19 HES hospital trusts and subsequently transferred to a neurology ward. (cdc.gov)
- Patients were randomly assigned (1:1) to receive 16 mg/day oral capsules of Nefecon or matching placebo for 9 months, followed by a 15-month observational follow-up period off study drug. (bvsalud.org)
- cysteine dioxygenase type 1 [Source:HGN. (gsea-msigdb.org)
- CUGBP Elav-like family member 1 [Source. (gsea-msigdb.org)
- E multistage diagnostic investigations of cases, provided a ncephalitis is associated with severe illness, apprecia- unique opportunity to complement routinely collected hos- ble mortality rates, and high health care costs ( 1 ), but pitalization data to enable detailed analyses of encephalitis its epidemiology remains poorly understood ( 2 ). (cdc.gov)
- cytochrome P450 family 1 subfamily A me. (gsea-msigdb.org)
- Sphingosine-1-phosphate regulation of mammalian development. (nih.gov)
- Severe impairments in neuronal migration during brain development lead to the neurodevelopmental disorder lissencephaly, characterized by smooth cerebral surface, absent or decreased gyri, thickened cortex and enlarged ventricles [ 1 , 16 ]. (biomedcentral.com)
- She has supervised several students (2 master students from the University of Bordeaux, 1 from the University of Bialystok, Poland and 1 graduate student from the University of Coimbra) and mentored several PhD students in the laboratory. (cienciavitae.pt)