Contactins: A family of immunoglobulin-related cell adhesion molecules that are involved in NERVOUS SYSTEM patterning.Contactin 1: A contactin subtype that is predominantly expressed in the CEREBELLUM; HIPPOCAMPUS; NEOCORTEX; and HYPOTHALAMUS.N-Acylsphingosine Galactosyltransferase: An enzyme that catalyzes the conversion of UDP-galactose and N-acylsphingosine to D-galactosylceramide and UDP.Myelin Sheath: The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.Receptors, Notch: A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN repeats in their cytoplasmic domains. The cytoplasmic domain of notch receptors is released upon ligand binding and translocates to the CELL NUCLEUS where it acts as transcription factor.Contactin 2: A contactin subtype that plays a role in axon outgrowth, axon fasciculation, and neuronal migration.Schwann Cells: Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.Polyradiculoneuropathy, Chronic Inflammatory Demyelinating: A slowly progressive autoimmune demyelinating disease of peripheral nerves and nerve roots. Clinical manifestations include weakness and sensory loss in the extremities and enlargement of peripheral nerves. The course may be relapsing-remitting or demonstrate a step-wise progression. Protein is usually elevated in the spinal fluid and cranial nerves are typically spared. GUILLAIN-BARRE SYNDROME features a relatively rapid progression of disease which distinguishes it from this condition. (Adams et al., Principles of Neurology, 6th ed, p1337)Polyradiculoneuropathy: Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (GUILLAIN-BARRE SYNDROME) and POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots.Guillain-Barre Syndrome: An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)Demyelinating Diseases: Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.Tremor: Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.Plasma Exchange: Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.Neurology: A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.Polyneuropathies: Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.Sural Nerve: A branch of the tibial nerve which supplies sensory innervation to parts of the lower leg and foot.Immunoglobulins, Intravenous: Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.Cell Adhesion Molecules, Neuronal: Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.Bilirubin: A bile pigment that is a degradation product of HEME.Estriol: A hydroxylated metabolite of ESTRADIOL or ESTRONE that has a hydroxyl group at C3, 16-alpha, and 17-beta position. Estriol is a major urinary estrogen. During PREGNANCY, a large amount of estriol is produced by the PLACENTA. Isomers with inversion of the hydroxyl group or groups are called epiestriol.Ranvier's Nodes: Regularly spaced gaps in the myelin sheaths of peripheral axons. Ranvier's nodes allow saltatory conduction, that is, jumping of impulses from node to node, which is faster and more energetically favorable than continuous conduction.Receptor-Like Protein Tyrosine Phosphatases, Class 5: A subclass of receptor-like protein tryosine phosphatases that contain an extracellular fibronectin III-like domain along with a carbonic anhydrase-like domain.Protein Tyrosine Phosphatases: An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Receptor-Like Protein Tyrosine Phosphatases, Class 3: A subclass of receptor-like protein tryosine phosphatases that contain a single cytosolic protein tyrosine phosphate domain and multiple extracellular fibronectin III-like domains.Receptor-Like Protein Tyrosine Phosphatases, Class 4: A subclass of receptor-like protein tryosine phosphatases that contain short highly glycosylated extracellular domains and two active cytosolic protein tyrosine phosphatase domains.Limbic Encephalitis: A paraneoplastic syndrome marked by degeneration of neurons in the LIMBIC SYSTEM. Clinical features include HALLUCINATIONS, loss of EPISODIC MEMORY; ANOSMIA; AGEUSIA; TEMPORAL LOBE EPILEPSY; DEMENTIA; and affective disturbance (depression). Circulating anti-neuronal antibodies (e.g., anti-Hu; anti-Yo; anti-Ri; and anti-Ma2) and small cell lung carcinomas or testicular carcinoma are frequently associated with this syndrome.Isaacs Syndrome: A rare neuromuscular disorder with onset usually in late childhood or early adulthood, characterized by intermittent or continuous widespread involuntary muscle contractions; FASCICULATION; hyporeflexia; MUSCLE CRAMP; MUSCLE WEAKNESS; HYPERHIDROSIS; TACHYCARDIA; and MYOKYMIA. Involvement of pharyngeal or laryngeal muscles may interfere with speech and breathing. The continuous motor activity persists during sleep and general anesthesia (distinguishing this condition from STIFF-PERSON SYNDROME). Familial and acquired (primarily autoimmune) forms have been reported. (From Ann NY Acad Sci 1998 May 13;841:482-496; Adams et al., Principles of Neurology, 6th ed, p1491)Potassium Channels: Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.Potassium: An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.Potassium Channels, Voltage-Gated: Potassium channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. The opening of these channels is induced by the membrane depolarization of the ACTION POTENTIAL.Myokymia: Successive and rapid contractions of motor units associated with chronic nerve injury. The discharges arise from the peripheral aspects of regenerating nerves, and clinically impart a nearly continuous undulation of the body surface overlying the muscle. (Adams et al., Principles of Neurology, 6th ed, p1491)Shaw Potassium Channels: A shaker subfamily that is prominently expressed in NEURONS and are necessary for high-frequency, repetitive firing of ACTION POTENTIALS.Cell Adhesion Molecules: Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.Cell Adhesion: Adherence of cells to surfaces or to other cells.Cadherins: Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.Selectins: Transmembrane proteins consisting of a lectin-like domain, an epidermal growth factor-like domain, and a variable number of domains that are homologous to complement regulatory proteins. They are important cell adhesion molecules which help LEUKOCYTES attach to VASCULAR ENDOTHELIUM.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Axons: Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Epitopes: Sites on an antigen that interact with specific antibodies.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.

Selective alterations in biosynthetic and endocytic protein traffic in Madin-Darby canine kidney epithelial cells expressing mutants of the small GTPase Rac1. (1/25)

Madin-Darby canine kidney (MDCK) cells expressing constitutively active Rac1 (Rac1V12) accumulate a large central aggregate of membranes beneath the apical membrane that contains filamentous actin, Rac1V12, rab11, and the resident apical membrane protein GP-135. To examine the roles of Rac1 in membrane traffic and the formation of this aggregate, we analyzed endocytic and biosynthetic trafficking pathways in MDCK cells expressing Rac1V12 and dominant inactive Rac1 (Rac1N17). Rac1V12 expression decreased the rates of apical and basolateral endocytosis, whereas Rac1N17 expression increased those rates from both membrane domains. Basolateral-to-apical transcytosis of immunoglobulin A (IgA) (a ligand for the polymeric immunoglobulin receptor [pIgR]), apical recycling of pIgR-IgA, and accumulation of newly synthesized GP-135 at the apical plasma membrane were all decreased in cells expressing Rac1V12. These effects of Rac1V12 on trafficking pathways to the apical membrane were the result of the delivery and trapping of these proteins in the central aggregate. In contrast to abnormalities in apical trafficking events, basolateral recycling of transferrin, degradation of EGF internalized from the basolateral membrane, and delivery of newly synthesized pIgR from the Golgi to the basolateral membrane were all relatively unaffected by Rac1V12 expression. Rac1N17 expression had little or no effect on these postendocytic or biosynthetic trafficking pathways. These results show that in polarized MDCK cells activated Rac1 may regulate the rate of endocytosis from both membrane domains and that expression of dominant active Rac1V12 specifically alters postendocytic and biosynthetic membrane traffic directed to the apical, but not the basolateral, membrane.  (+info)

Transgenic mice expressing F3/contactin from the TAG-1 promoter exhibit developmentally regulated changes in the differentiation of cerebellar neurons. (2/25)

F3/contactin (CNTN1) and TAG-1 (CNTN2) are closely related axonal glycoproteins that are differentially regulated during development. In the cerebellar cortex TAG-1 is expressed first as granule cell progenitors differentiate in the premigratory zone of the external germinal layer. However, as these cells begin radial migration, TAG-1 is replaced by F3/contactin. To address the significance of this differential regulation, we have generated transgenic mice in which F3/contactin expression is driven by TAG-1 gene regulatory sequences, which results in premature expression of F3/contactin in granule cells. These animals (TAG/F3 mice) display a developmentally regulated cerebellar phenotype in which the size of the cerebellum is markedly reduced during the first two postnatal weeks but subsequently recovers. This is due in part to a reduction in the number of granule cells, most evident in the external germinal layer at postnatal day 3 and in the inner granular layer between postnatal days 8 and 11. The reduction in granule cell number is accompanied by a decrease in precursor granule cell proliferation at postnatal day 3, followed by an increase in the number of cycling cells at postnatal day 8. In the same developmental window the size of the molecular layer is markedly reduced and Purkinje cell dendrites fail to elaborate normally. These data are consistent with a model in which deployment of F3/contactin on granule cells affects proliferation and differentiation of these neurons as well as the differentiation of their synaptic partners, the Purkinje cells. Together, these findings indicate that precise spatio-temporal regulation of TAG-1 and F3/contactin expression is critical for normal cerebellar morphogenesis.  (+info)

Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma. (3/25)

Numerous genetic changes are associated with cancer cell metastasis and invasion. In search for key regulators of invasion and metastasis, a panel of lung cancer cell lines with different invasive ability was screened. The gene for contactin-1 was found to play an essential role in tumor invasion and metastasis. Suppression of contactin-1 expression abolished the ability of lung adenocarcinoma cells to invade Matrigel in vitro as well as the polymerization of filamentous-actin and the formation of focal adhesion structures. Furthermore, knockdown of contactin-1 resulted in extensive inhibition of tumor metastasis and in increased survival in an animal model. RhoA but not Cdc42 or Rac1 was found to serve a critical role in contactin-1-mediated invasion and metastasis. Contactin-1-specific RNA interference resulted in loss of metastatic and invasive capacity in both in vitro and in vivo models. This loss was overturned by constitutive expression of the active form of RhoA. Contactin-1 was differentially expressed in tumor tissues, and its expression correlated with tumor stage, lymph node metastasis, and patient survival. Contactin-1 is proposed to function importantly in the invasion and metastasis of lung adenocarcinoma cells via RhoA-mediated mechanisms.  (+info)

The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. (4/25)

Flt-4, a VEGF receptor, is activated by its specific ligand, VEGF-C. The resultant signaling pathway promotes angiogenesis and/or lymphangiogenesis. This report provides evidence that the VEGF-C/Flt-4 axis enhances cancer cell mobility and invasiveness and contributes to the promotion of cancer cell metastasis. VEGF-C/Flt-4-mediated invasion and metastasis of cancer cells were found to require upregulation of the neural cell adhesion molecule contactin-1 through activation of the Src-p38 MAPK-C/EBP-dependent pathway. Examination of tumor tissues from various types of cancers revealed high levels of Flt-4 and VEGF-C expression that correlated closely with clinical metastasis and patient survival. The VEGF-C/Flt-4 axis, through upregulation of contactin-1, may regulate the invasive capacity in different types of cancer cells.  (+info)

Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin. (5/25)

Post-Golgi to apical surface delivery in polarized epithelial cells requires the cytoplasmic dynein motor complex. However, the nature of dynein-cargo interactions and their underlying regulation are largely unknown. Previous studies have shown that the apical surface targeting of rhodopsin requires the dynein light chain, Tctex-1, which binds directly to both dynein intermediate chain (IC) and rhodopsin. In this report, we show that the S82E mutant of Tctex-1, which mimics Tctex-1 phosphorylated at serine 82, has a reduced affinity for dynein IC but not for rhodopsin. Velocity sedimentation experiments further suggest that S82E is not incorporated into the dynein complex. The dominant-negative effect of S82E causes rhodopsin mislocalization in polarized Madin-Darby canine kidney (MDCK) cells. The S82A mutant, which mimics dephosphorylated Tctex-1, can be incorporated into dynein complex but is impaired in its release. Expression of S82A also causes disruption of the apical localization of rhodopsin in MDCK cells. Taken together, these results suggest that the dynein complex disassembles to release cargo due to the specific phosphorylation of Tctex-1 at the S82 residue and that this process is critical for the apical delivery of membrane cargoes.  (+info)

Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. (6/25)

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Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E. (7/25)

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The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. (8/25)

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*Contactin 1

... , also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene. The protein encoded by this gene ... "Entrez Gene: CNTN1 contactin 1". Sakurai T, Lustig M, Nativ M, Hemperly JJ, Schlessinger J, Peles E, Grumet M (Feb 1997). " ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ... "Contactin associates with Na+ channels and increases their functional expression". The Journal of Neuroscience. 21 (19): 7517- ...

*Contactin

Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the ... The subgroup consists of six members now referred to as contactin 1-6, but historically they had different names as shown in ... "Contactins". Cell Adh Migr. 3 (1): 64-70. PMC 2675151 . PMID 19262165 - via PubMed Central. ... the table below: Shimoda, Yasushi; Watanabe, Kazutada (1 January 2009). " ...

*CASPR

"Contactin-Associated Protein (Caspr) and Contactin Form a Complex That Is Targeted to the Paranodal Junctions during ... CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 ... The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino ... During myelination, caspr associates with contactin in a cis complex, though its precise role in myelination is not yet ...

*Clostridium septicum

... as well as the neuronal molecules contactin and Thy-1 (CD90). Quite surprisingly, the alpha toxin of C. septicum is not related ... 4 (4): 1-9. doi:10.1371/journal.ppat.1000045. PMC 2275794 . PMID 18404211. Ballard, J; Bryant, A; Stevens, D; Tweten, RK (1992 ... 63 (1): 340-344. Melton-Witt, JA; Bensten, LM; Tweten, RK (2006). "Identification of functional domains of clostridium septicum ... In a Canadian survey from 2000 to 2006, 19 isolates were tested and 9 (47%) were resistant to clindamycin and 1 (5%) was ...

*LGI1

Leucine-rich, glioma inactivated 1, also known as LGI1, is a protein which in humans is encoded by the LGI1 gene. It may be a ... 51 (6): 1730-1. doi:10.1212/wnl.51.6.1730. PMID 9855534. Kalachikov S, Evgrafov O, Ross B, Winawer M, Barker-Cummings C, ... 10 (1): 56-60. doi:10.1038/ng0595-56. PMC 2823475 . PMID 7647791. Wilson MH, Puranam RS, Ottman R, Gilliam C, Limbird LE, ... The leucine-rich glioma inactivated -1 gene is rearranged as a result of translocations in glioblastoma cell lines. The protein ...

*Autoimmune encephalitis

Contactin-associated protein like (CASPR2), associated with a broader spectrum of central and peripheral nervous system ... In some patients VGKC Abs are detected by radioimmunoassay, in the absence of LGI1, CASPR2, or contactin 2 Ab specificity. In ... glioma inactivated protein and contactin-associated protein like, that are associated with voltage-gated potassium channels. ... 204 (1): 1-31. doi:10.1016/j.bbr.2009.06.008. PMID 19523490. Klein, C.; Brin, M. F.; Kramer, P.; Sena-Esteves, M.; de Leon, D ...

*Anti-VGKC-complex encephalitis

5 had antibodies against Contactin-2 and 18 (19%) had antibodies with unknown specificity. Of the patients with Contactin-2 ... 19 had antibodies reacting with Contactin-associated protein 2 (CASPR 2), ... The mean incidence of anti-LGI1 in Denmark is 1,1 per million compared to 3,3 per million for anti-NMDAR antibodies (NR1). The ... anti-LGI-1 encephalitis: Patients with anti-LGI1 encephalitis have limbic encephalitis with amnesia and/or confusion (100%) and ...

*Sodium channel

Contactin, also known as F3 or F11, associates with beta 1 as shown via co-immunoprecipitation. Fibronectin-like (FN-like) ... Shah BS, Rush AM, Liu S, Tyrrell L, Black JA, Dib-Hajj SD, Waxman SG (August 2004). "Contactin associates with sodium channel ... "Contactin associates with Na+ channels and increases their functional expression". J. Neurosci. 21 (19): 7517-25. PMID 11567041 ... 26 (1): 13-25. doi:10.1016/S0896-6273(00)81133-2. PMID 10798388. Isom LL, De Jongh KS, Patton DE, Reber BF, Offord J, ...

*Contactin 3

Contactin-3 is a protein that in humans is encoded by the CNTN3 gene. GRCh38: Ensembl release 89: ENSG00000113805 - Ensembl, ... "Entrez Gene: CNTN3 contactin 3 (plasmacytoma associated)". Human CNTN3 genome location and CNTN3 gene details page in the UCSC ... 2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression ... 69 (1): 113-9. doi:10.1006/geno.2000.6310. PMID 11013081. Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the ...

*CNTNAP2

Contactin-associated protein-like 2 is a protein that in humans is encoded by the CNTNAP2 gene. Since the most recent reference ... "Entrez Gene: CNTNAP2 contactin associated protein-like 2". Ashley, Euan A. (16 August 2016). "Towards precision medicine". ... Nakabayashi K, Scherer SW (April 2001). "The human contactin-associated protein-like 2 gene (CNTNAP2) spans over 2 Mb of DNA at ... "Recessive symptomatic focal epilepsy and mutant contactin-associated protein-like 2". The New England Journal of Medicine. 354 ...

*Notch signaling pathway

... such as F3/contactin. In the nematode C. elegans, two genes encode homologous proteins, glp-1 and lin-12. There has been at ... 266 (1): 161-77. doi:10.1016/j.ydbio.2003.10.017. PMID 14729486. Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, Jan LY ... 122 (1): 3-25. doi:10.1016/j.mod.2004.08.006. PMID 15582774. Austin J, Kimble J (Nov 1987). "glp-1 is required in the germ line ... 183 (1): 129-141. doi:10.1083/jcb.200806104. Zhao, L.; Borikova, A. L.; Ben-Yair, R.; Guner-Ataman, B.; MacRae, C. A.; Lee, R. ...

*Chromosome 3 (human)

Contactin 4 COL7A1: Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) CRBN: Cereblon ... ISBN 978-1-136-84407-2. Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last ... Partial list of the genes located on p-arm (short arm) of human chromosome 3: ALAS1: aminolevulinate, delta-, synthase 1 APEH: ... C3orf23: encoding protein Uncharacterized protein C3orf23 C3orf60/NDUFAF3: encoding enzyme NADH dehydrogenase [ubiquinone] 1 ...

*Contactin 2

Contactin-2 is a protein that in humans is encoded by the CNTN2 gene. The protein encoded by this gene is a member of the ... "Entrez Gene: CNTN2 contactin 2 (axonal)". Traka M, Goutebroze L, Denisenko N, Bessa M, Nifli A, Havaki S, Iwakura Y, Fukamauchi ... 1 (2): 105-16. doi:10.1016/0896-6273(88)90194-8. PMID 3272160. Kenwrick S, Leversha M, Rooke L, Hasler T, Sonderegger P (Sep ... 211 (1-2): 329-39. doi:10.1111/j.1432-1033.1993.tb19902.x. PMID 8425542. Kozlov SV, Giger RJ, Hasler T, Korvatska E, Schorderet ...

*ARFGEF1

Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M (Mar 2004). "Nuclear ... 69 (1): 113-9. doi:10.1006/geno.2000.6310. PMID 11013081. Check date values in: ,year= / ,date= mismatch (help) Padilla PI, ... Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene. ADP- ...

*ARFGEF2

Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: ... 36 (1): 69-76. doi:10.1038/ng1276. PMID 14647276. Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, ... 69 (1): 113-9. doi:10.1006/geno.2000.6310. PMID 11013081. Pacheco-Rodriguez G, Moss J, Vaughan M (2002). "BIG1 and BIG2: ... Kuroda F, Moss J, Vaughan M (Feb 2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and ...

*Heritability of autism

Molecular cytogenetic analysis and resequencing of Contactin Associated Protein-Like 2 in autism spectrum disorders. Am J Hum ... 2003;40(1):e4. doi:10.1136/jmg.40.1.e4. PMID 12525552. Auranen M, Varilo T, Alen R, et al. Evidence for allelic association on ... 2006;87(1):75-83. doi:10.1016/j.ygeno.2005.09.008. PMID 16311013. Skaar DA, Shao Y, Haines JL, et al. Analysis of the RELN gene ... 2007;12(1):2-22. doi:10.1038/sj.mp.4001896. PMID 17033636. Sykes NH, Lamb JA. Autism: the quest for the genes. Expert Rev Mol ...

*Pitt-Hopkins syndrome

A Pitt-Hopkins like phenotype has been assigned to autosomal recessive mutations of the contactin associated protein like 2 ( ... CNTNAP2) gene on the long arm of chromosome 7 (7q33-q36) and the neurexin 1 alpha (NRXN1) gene on the short arm of chromosome 2 ...

*L1 family

... members also bind "heterophilically" to members of the contactin or CNTN1 family. L1 family members bind to many ... NrCAM and neurofascin both have class 1 PDZ domain binding motifs at their COOH termini. NrCAM can bind to SAP102 and other ...

*Contactin 4

Contactin-4 is a protein that in humans is encoded by the CNTN4 gene. The protein encoded by this gene is a member of the ... 2006). "The contactin 4 gene locus at 3p26 is a candidate gene of SCA16". Neurology. 67 (7): 1236-41. doi:10.1212/01.wnl. ... 2004). "Disruption of contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome". Am. J. ... 2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression ...

*Generalized epilepsy with febrile seizures plus

This extracellular region is similar to the cell adhesion molecule contactin and other cell adhesion molecules. It is believed ... GEFS+ type 1 is a subtype of GEFS+ in which there are mutations in SCN1B, a gene encoding a sodium channel β subunit. The β ... 116 (1): 37-48. doi:10.1016/S0306-4522(02)00698-X. PMID 12535936. Singh R, Andermann E, Whitehouse W, Harvey A, Keene D, Seni M ... 53 (1-2): 107-17. doi:10.1016/S0920-1211(02)00259-0. PMID 12576172. Barela A, Waddy S, Lickfett J, Hunter J, Anido A, Helmers S ...

*NFASC

Gollan L, Salomon D, Salzer JL, Peles E (2004). "Caspr regulates the processing of contactin and inhibits its binding to ... 2002). "Neurofascin is a glial receptor for the paranodin/Caspr-contactin axonal complex at the axoglial junction". Curr. Biol ... 118 (1): 149-61. doi:10.1083/jcb.118.1.149. PMC 2289533 . PMID 1377696. Burmeister M, Ren Q, Makris GJ, Samson D, Bennett V ( ... Koroll M, Rathjen FG, Volkmer H (2001). "The neural cell recognition molecule neurofascin interacts with syntenin-1 but not ...

*List of Celebrity Big Brother (UK) housemates

... www.bbspy.co.uk/cbb11/news/0123/more-outside-contact-in-viewers-venom-task-opinions-celeb-bb-2013 [2] "Vanessa Feltz, Danielle ... 1][dead link] Harp, Justin (25 August 2012). "CBB: Jasmine Lennard's mum Marilyn fails secret task". Digital Spy. Retrieved 26 ... http://www.bbspy.co.uk/cbb11/news/0123/more-outside-contact-in-viewers-venom-task-opinions-celeb-bb-2013 http:// ... 1 September 2015. Retrieved 26 January 2016. "Day 7: Watch the sabotaged royal interview". Channel 5. 2 September 2015. ...

*CNTNAP4

Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene. This gene product belongs to ... "Entrez Gene: CNTNAP4 contactin associated protein-like 4". Human CNTNAP4 genome location and CNTNAP4 gene details page in the ... 16 (1): 55-65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560. Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial ...

*SCN3A

2004). "Contactin associates with sodium channel Nav1.3 in native tissues and increases channel density at the cell surface". J ... 10 (1): 67-70. doi:10.1007/BF02737087. PMID 9589372. Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding ... 7 (1): 65-73. doi:10.1093/dnares/7.1.65. PMID 10718198. Gotthardt M, Trommsdorff M, Nevitt MF, et al. (2000). "Interactions of ... 264 (1): 113-22. doi:10.1016/S0378-1119(00)00594-1. PMID 11245985. Whitaker WR, Faull RL, Dragunow M, et al. (2001). "Changes ...

*NRCAM

1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine ... 12 (1): 1-10. doi:10.1017/S1461145708009127. PMID 18664314. Grumet M (1997). "Nr-CAM: a cell adhesion molecule with ligand and ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Hutcheson HB, Olson LM, Bradford Y, et al. (2004). "Examination of NRCAM, ... 154 (1): 187-96. doi:10.1083/jcb.200104038. PMC 2196853 . PMID 11449000. Dry K, Kenwrick S, Rosenthal A, Platzer M (2001). "The ...

*Nav1.2

... beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ... 303 (1): 53-8. doi:10.1016/0014-5793(92)80476-W. PMID 1317301. Ahmed CM, Ware DH, Lee SC, et al. (1992). "Primary structure, ... 81 (1-2): 187-90. doi:10.1016/S0169-328X(00)00145-5. PMID 11000491. Kasai N, Fukushima K, Ueki Y, et al. (2001). "Genomic ... 264 (1): 113-22. doi:10.1016/S0378-1119(00)00594-1. PMID 11245985. Malacarne M, Gennaro E, Madia F, et al. (2001). "Benign ...
Complete information for CNTN2 gene (Protein Coding), Contactin 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for CNTN2 gene (Protein Coding), Contactin 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
CNTN1 - CNTN1 (untagged)-ORIGENE UNIQUE VARIANT 1 of Human contactin 1 (CNTN1), available for purchase from OriGene - Your Gene Company.
Mouse monoclonal antibody raised aginst synthetic peptide of Cntn1. A synthetic peptide corresponding to amino acids of 21-37 at extracellular domain of rat Cntn1. (MAB11957) - Products - Abnova
Rabbit polyclonal antibody raised against recombinant CNTN1. Recombinant protein corresponding to amino acids of human CNTN1. (PAB23744) - Products - Abnova
Th TNR CN-GM. FCT: Trp ∓ Kll fld bcs cts cnnt b trppd fstr thn th xpnntll brd t f cntrl.. FCT: Trp ∓ Strlz (TNR) s n vn bggr bjct flr bcs ths mn-md clgcl dsstrs cnnt b trppd fstr thn th xpnntll brd t f cntrl, nd th ls cntn th crll nnhlt ll ntv wldlf (frm th smllst f pr p t th tp prdtrs tht r strvd t dth), nd th cts cntn t sprd mn ddl dsss tht th crr td - FR WHCH THR R N VCCNS GNST THM. Mn f whch r vn lstd s btrrrsm gnts. (Sch s Tlrm nd Th Plg - s, ppl hv lrd dd frm ct-trnsmttd plg n th S. N fls nr rts vn rqrd. Th cts thmslvs crr nd trnsmt th plg ll n thr wn.). FCT: THR S BSLTL _NTHNG_ HMN BT TNR. Nrl vr lst TNRd ct ds n nhmn dth b rd-kll, frm ct nd nml ttcks, nvrnmntl psns, strvtn, dhdrtn, frzng t dth, nfctns, prsts, tc. nd f vr vr lck hmnl sht t dth r r-trppd nd drwnd (th tw mst cmmn mthds mpld n ll frms nd rnchs t prtct thr gsttng lvstcks ffsprng nd vlbl ntv wldlf dng frm cts Txplsmss prsts). Ths dsnt bgn t cnt th thsnds f dfnslss ntv nmls tht cts skn lv nd dsmbwl lv fr thr dl nd hrl ...
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
View mouse Cntnap4 Chr8:112570043-112882717 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
tdn yrslf ths tm PZ, rlly? Y hv n grsp n hw th lgl systm wrks n ths cntry thr? nncnt ntl prvn glty. Shw prf r STF. gss w dd bsc lw t th lst lng wth skptcsm f thngs y knw jck sht bt. Y knw wh shckfgd s PZ? Y rmnd m f hm wth yr sht. H t wld mk ths knds f clms bt rlgn nd nvr hv bt f vdnc. Y r pthtc. dnt knw wht gv y th brght d tht sggstng ws glty f dntty thft ws gd d bt cn ssr y, t wsnt. m nt gng t pll sm lm stnt lk y dscrb hr, thr s n pnt n t. Wht m gng t cntn t d s pnt t yr lck f cmmn sns nd rdcl y bcs y dsrv t. Y spk f cwrdc whl y pst blgs bt m nd prdly cckl bt hw y wll nt llw m t dfnd myslf. Y r th cwrd y npt fl. Y bnd nd gg yr ppnnt thn prdly brg bt hw y cn kck thr ss. Ww th sprr ntllct rlly s w nsprng PZ. Wh d y thnk s mprssd? Why d y nd s bdly t mprss nyn? s yr vl slf wrth rlly s lw?Th sd thng s y r nly hrtng yrslf, th nly ppl wh fll fr yr lttl gms r ll jst s blnd s y t wht bng skptcl s. knw y r md t m PZ, nd y r gng t b vn mr pst m frd bcs y r jst t dmn dmb t lrn hw t sht p. dnt nd t ...
Yoshihara Y, Kawasaki M, Tamada A; et al. (1996). «Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily.». J. Neurobiol. 28 (1): 51-69. PMID 8586965. doi:10.1002/neu.480280106 ...
Two experiments were carried out to address the question of whether PTPα and contactin associate in a cis or trans conformation. First, anticontactin precipitates were prepared from lysates of COS cells expressing either PTPα or contactin, or from cells coexpressing both PTPα and contactin ( Fig. 5 A, lanes 1-3), as well as from another sample made by mixing lysates from the cells expressing either contactin or PTPα ( Fig. 5 A, lane 4). Anticontactin immunoprecipitates prepared from coexpressing cells contained PTPα, but those from mixed cell lysates did not ( Fig. 5 A, bottom, lanes 7 and 8). The lack of detectable association of PTPα and contactin in the mixed lysates suggests that interaction cannot take place in a trans conformation. Still, this may require a particular presentation of these cell surface molecules in growing cells that cannot form in solubilized cell lysates. Therefore, contactin-expressing cells were trypsinized 24 h after transfection and replated in dishes ...
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
Expression of CNTN2 (AXT, TAG-1, TAX, TAX1) in tonsil tissue. Antibody staining with HPA001397 and HPA012497 in immunohistochemistry.
Expression of CNTN2 (AXT, TAG-1, TAX, TAX1) in epididymis tissue. Antibody staining with HPA001397 and HPA012497 in immunohistochemistry.
TY - JOUR. T1 - A synthetic peptide derived from the sequence of a type I collagen receptor inhibits type I collagen-mediated platelet aggregation. AU - Chiang, Thomas M.. AU - Kang, Andrew. PY - 1997/10/15. Y1 - 1997/10/15. N2 - A synthetic peptide-1, an 18 amino acid residue peptide derived from a hydrophilic domain of a cloned platelet type I collagen receptor, was used to study the role of the receptor on types I and III collagen-induced platelet aggregation and the release of ATP. The peptide inhibits the type I, but not the type III, collagen-induced platelet aggregation and the release of ATP in a dose-dependent manner. The [125I]peptide-1 specifically binds to type I collagen-coated microtiter wells in a dose-dependent manner (with K(d) = 10 nM). The binding of [125I]peptide-1 can be inhibited by an excess of unlabeled peptide-1 suggesting that the binding is specific. The labeled peptide-1 does not bind to type III collagen-coated microtiter wells. Results from an enzyme-linked ...
The aim of this study was to investigate the potential of cell-free DNA (cfDNA) as a disease biomarker in oesophageal squamous cell carcinoma (ESCC) that can be used for treatment response evaluation and early detection of tumour recurrence. Matched tumour tissue, pre- and post-surgery plasma and WBCs obtained from 17 ESCC patients were sequenced using a panel of 483 cancer-related genes. Somatic mutations were detected in 14 of 17 tumour tissues. Putative harmful mutations were observed in genes involved in well-known cancer-related pathways, including PI3K-Akt/mTOR signalling, Proteoglycans in cancer, FoxO signalling, Jak-STAT signalling, Chemokine signalling and Focal adhesion. Forty-six somatic mutations were found in pre-surgery cfDNA in 8 of 12 patients, with mutant allele frequencies (MAF) ranging from 0.24 to 4.91%. Three of the 8 patients with detectable circulating tumour DNA (ctDNA) had stage IIA disease, whereas the others had stage IIB-IIIB disease. Post-surgery cfDNA somatic mutations were
MicroRNA Polymorphisms and Environmental Smoke Exposure as Risk Factors for Oesophageal Squamous Cell Carcinoma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Golgi analyses showed abnormal dendritic arborisation of hippocampal CA1 neurons and an increased hippocampal volume. Furthermore, it was also investigated whether these changes correlated with deficits in learning and memory behaviour. For that purpose, short- and long-term recognition memory, spatial memory and fear conditioning responses were assessed. These behavioural studies showed increased contextual fear conditioning in heterozygous and homozygous KO mice, quantified by a gene-dose dependent increase in freezing response. In comparison to wild-type mice, Cntn4-deficient animals froze significantly less and groomed more, indicative of increased stress responsiveness under the test conditions. In addition, we tested if Cntn4 gene expression affects CA1 synaptic transmission and the ability to induce LTP in hippocampal slices. Stimulation in CA1 stratum radiatum with 900 pulses at 10 Hz and 1 pulse at 100 Hz decreased significant synaptic potentiation in Cntn4 KO mice. Our neuro-anatomical ...
Mice homozygous for the recessive buff (|i|Vps33a|sup|bf|/sup||/i|) mutation on a non-agouti (|i|a|/i|/|i|a|/i|) background have a lightened coat color that has been described as khaki. On an agouti background, |i|Vps33a|sup|bf|/sup||/i| homozygotes have dark ears, opaque eyes, and the belly is lighter in color than is the rest of the coat. Although no change in eye color is outwardly evident, electron microscopy shows fewer and smaller melanosomes than normal in the retinal pigment epithelium and choroid. These mutants have a platelet-storage pool defect evidenced by an increased bleeding time of 9.7 minutes on average, a reduction in the number of platelet dense granules, and slightly decreased collagen-mediated platelet aggregation, secretion of dense-granule ATP and secretion of seratonin. Hakansson and Lundin found increased activity of the lysosomal glycosidases beta- galactosidase, beta-glucuronidase, and N-acetyl-beta-hexosaminidase in kidney cell lysates. Suzuki |i|et al.|/i| found no
TABLE-US-00004 TABLE 4 Cell and biological adhesion Fold Symbol Gene name Gene assignment change CLDN7 claudin 7 Involved in the formation of 2.74 tight junctions between epithelial cells PCDHB5 Protocadherin Member of the 3.32 beta-5 protocadherin beta gene cluster CLDN3 Claudin 3 Member of the claudin 3.93 family, is an integral membrane protein and a component of tight junction strands. CNTN6 contactin 6 Contactins mediate cell 3.09 surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. PKHD1 polycystic kidney Localized predominantly at 3.38 and hepatic the disease 1 apical domain of polarized epithelial cells, suggesting it may be involved in the tubulogenesis and/or maintenance of duct-lumen architecture. PCDHB2 protocadherin The extracellular domains 2.94 beta 2 interact in a homophilic manner to specify differential cell-cell connections. CDH1 E-cadherin cell adhesion molecule 3.27 (epithelial) CX3CL1 hemokine ...
Several reports have pointed out that the ECM inhibits regeneration and suppresses plasticity in the adult CNS (Berardi et al., 2004; Fitch and Silver, 2008; Gervasi et al., 2008). By comparison, the role of the ECM in the stem and precursor cell microenvironment remains obscure, although the cellular microenvironment is crucial for stem cell maintenance and self-renewal (Scadden, 2006). Focusing on OPCs as a model, we reveal an inhibitory function of the ECM glycoprotein Tnc on differentiation and disentangle molecular details of ECM pathways designed to suppress the differentiation of a committed neural precursor cell. We show that Tnc suppresses the expression of MBP in oligodendrocytes both in vitro and in vivo during postnatal forebrain development, confirming its biological significance. The underlying signaling cascade requires the cell surface receptor Cntn1 and the associated Fyn kinase, and involves the regulation of the signaling adaptor and splice regulator Sam68. We further document ...
Background The aetiological role of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) has been widely researched for more than three decades, with conflicting findings. In the absence of a large, adequately powered single case-control study, a meta-analysis of all available case-control studies is the most rigorous way of identifying any potential association between HPV and OSCC. We present the first global meta-analysis of case-control studies investigating the role of HPV in OSCC. Methods Case-control studies investigating OSCC tissue for presence of HPV DNA were identified. 21 case-control studies analyzing a total of 1223 cases and 1415 controls, met our inclusion criteria. HPV detection rates were tabulated for each study and all studies were assessed for quality. The random effects method was used to pool the odds ratios (OR). Results From all OSCC specimens included in this meta-analysis, 35% (426/1223) were positive for HPV DNA. The pooled OR for an HPV-OSCC association
BACKGROUND: A neuroinflammatory response is suggested to play an important role in delirium, a common complication in older hospitalized patients. We examined whether hip fracture patients who develop postoperative delirium have a different proteome in cerebrospinal fluid (CSF) prior to surgery. METHODS: Patients (≥ 75 years) were admitted for hip ... read more fracture surgery. CSF was collected during spinal anaesthesia; proteins were separated using gel electrophoresis and identified with mass spectrometry. We compared the proteome of patients with and without postoperative delirium. Findings were validated in an independent, comparable cohort using immuno-assays. RESULTS: In the derivation cohort 53 patients were included, 35.8% developed postoperative delirium. We identified differences in levels of eight CSF proteins between patients with and without subsequent delirium: complement factor C3, contactin-1, fibulin-1 and I-beta-1,3-N-acetylglucosaminyltransferase were significantly lower ...
A 20-month-old boy - offspring of consanguinous parents, whose mother presumably had subclinical myopathy - presented with clinical signs of congenital non-progressive myopathy, neurogenic-myogenic...
A new technically suitable feature regarding gliomas will be the really infiltrative development style. Hence, PTPs which are regarded or believed to be linked to adhesion along with migration connected with cellular material have earned particular attention. Several of your PTP genes that show transformed concept stages in the extremely dangerous GBM subtype have already been linked to cellular bond: PTPRD, PTPRM plus DUSP26. Additionally, PTPRZ, DUSP1, PTP4A3 and also CDKN3, just about all suggested as a factor Calcitriol inside management of cell phone migration, exhibit aberrant term quantities with GBM specimens. It can be appealing to invest these particular variations help with the glues as well as migratory modifications with glioma cellular material. Confounding issues around glioma exploration At this point, the attained advice about your molecular elements underlying gliomagenesis hasnt but resulted in significantly improved remedy techniques for GBM clients. Various motives may be ...
A genetic defect causing autism and epilepsy involving the contactin associatedprotein-like 2 gene (CNTNAP2) has been discovered in a selected cohort of Amishchildren. These children were found to have focal seizures and autisticregression. Surgical biopsy of the anterior temporal lobe of two such childrenrevealed cortical dysplasia and a single nucleotide polymorphismmutation of this gene. The present case is that of a related but geographically distant probandwith a similar phenotype but a single-base-pair deletion in the CNTNAP2 gene.This patient exhibited the additional features of periventricular leukomalaciaand hepatomegaly ...
Oesophageal Squamous Cell Carcinoma African Prevention Research (ESCCAPE): a collaborative research effort to investigate the etiological epidemiology of squamous cell oesophageal carcinoma in the high-incidence belt in East Africa; major case-control studies are ongoing in Eldoret (Kenya), in Moshi, Kilimanjaro (the United Republic of Tanzania), and in Blantyre (Malawi) with further pilot work being conducted in Ethiopia (http://esccape.iarc.fr ...
Design The authors used transgenic mice in which the Hh receptor Patched1 (Ptch1) could be conditionally inactivated in a body-wide manner and mice in which Gli1 could be induced specifically in the epithelium of the skin and oesophagus. Effects on epithelial homeostasis of the oesophagus were examined using immunohistochemistry, in situ hybridisation, transmission electron microscopy and real-time PCR. Hh signalling was examined in patients with oesophageal squamous cell carcinoma (SCC) by quantitative real-time PCR.. ...
Results High reactivity to contactin-1 by ELISA was found in four patients with chronic inflammatory demyelinating polyradiculoneuropathy and in none of the patients with Guillain-Barré syndrome, which was confirmed by cell binding assays in all four patients. The four patients presented with a typical clinical picture, namely acute onset of disease and severe motor symptoms, with three patients manifesting action tremor. Immunofluorescence-labelling of paranodal proteins of dermal myelinated fibres revealed disruption of paranodal architecture. Semithin sections showed axonal damage but no classical signs of demyelination. ...
... , Authors: Cornelis P Tensen, Remco van Doorn. Published in: Atlas Genet Cytogenet Oncol Haematol.
Fungus Mrc1 ortholog of metazoan Claspin is normally both a central element of regular DNA replication forks and a mediator from the S phase checkpoint. replication devices should be sequentially set up and specifically programmed in a way that S stage is normally appropriately built-into the cell routine. Development and Set up take place through the M/G1 stages from the cell routine. Furthermore the replication devices must be covered during S stage because progress from the replication machine along the template while sequential isnt constant. Replication forks stall regularly either Rabbit Polyclonal to CNTN2. in difficult-to-replicate parts of the genome or because of exogenous environmental disturbance. Preventing replication forks from irreversibly collapsing in S stage when de novo set ML 786 dihydrochloride up is normally no longer allowed becomes a remarkable question. Cells will need to have a system to stabilize the replication equipment in situ until aberrant buildings can be taken ...

Destruction of paranodal architecture in inflammatory neuropathy with anti-contactin-1 autoantibodies | Journal of Neurology,...Destruction of paranodal architecture in inflammatory neuropathy with anti-contactin-1 autoantibodies | Journal of Neurology,...

Anti-contactin-1-associated neuropathy does not meet morphological criteria of demyelinating neuropathy and therefore, might ... Methods We used ELISA to detect autoantibodies against contactin-1. Specificity of the autoantibodies was confirmed by ... Results High reactivity to contactin-1 by ELISA was found in four patients with chronic inflammatory demyelinating ... Interpretation We conclude that anti-contactin-1-related neuropathy constitutes a presumably autoantibody-mediated form of ...
more infohttp://jnnp.bmj.com/content/86/7/720

Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease<...Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease<...

Antibodies targeting the Ranvier node proteins such as contactin-1, contactin-associated protein 1, and neurofascin 155 have ... Antibodies targeting the Ranvier node proteins such as contactin-1, contactin-associated protein 1, and neurofascin 155 have ... Antibodies targeting the Ranvier node proteins such as contactin-1, contactin-associated protein 1, and neurofascin 155 have ... Antibodies targeting the Ranvier node proteins such as contactin-1, contactin-associated protein 1, and neurofascin 155 have ...
more infohttps://ucdavis.pure.elsevier.com/en/publications/chronic-inflammatory-demyelinating-polyneuropathy-as-an-autoimmun

Contactin 1 - WikipediaContactin 1 - Wikipedia

Contactin 1, also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene. The protein encoded by this gene ... "Entrez Gene: CNTN1 contactin 1". Sakurai T, Lustig M, Nativ M, Hemperly JJ, Schlessinger J, Peles E, Grumet M (Feb 1997). " ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ... "Contactin associates with Na+ channels and increases their functional expression". The Journal of Neuroscience. 21 (19): 7517- ...
more infohttps://en.wikipedia.org/wiki/Contactin_1

CNTN1 - Contactin-1 precursor - Homo sapiens (Human) - CNTN1 gene & proteinCNTN1 - Contactin-1 precursor - Homo sapiens (Human) - CNTN1 gene & protein

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo- ... IPR036992. Contactin-1. IPR003961. FN3_dom. IPR036116. FN3_sf. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig ... IPR036992. Contactin-1. IPR003961. FN3_dom. IPR036116. FN3_sf. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig ... Cluster: Contactin-1. 140. Q12860-3. UPI000B541AE2. UPI000643459F. UPI0002C47707. UPI00054040F8. UPI0003F17F70. UPI000703EA1B. ...
more infohttp://www.uniprot.org/uniprot/Q12860

CNTN1 / gp135 / Contactin 1 Antibody (N-Terminal) for ELISA, WB/WesternCNTN1 / gp135 / Contactin 1 Antibody (N-Terminal) for ELISA, WB/Western

Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse ... CNTN1 / gp135 / Contactin 1 Antibody (aa81‑130, FITC) LS‑C466250 Species: Human, Chimpanzee, Orangutan, Gibbon, Monkey, Rat, ... Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse ... Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse ...
more infohttps://www.lsbio.com/antibodies/cntn1-antibody-gp135-antibody-contactin-1-antibody-n-terminus-elisa-wb-western-ls-c386882/398983

CNTN1 / gp135 / Contactin 1 Antibody (aa736-1003, PE) for IHC, WB/WesternCNTN1 / gp135 / Contactin 1 Antibody (aa736-1003, PE) for IHC, WB/Western

Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). Validated ... CNTN1 / gp135 / Contactin 1 Antibody (aa81‑130, FITC) LS‑C466250 Species: Human, Chimpanzee, Orangutan, Gibbon, Monkey, Rat, ... Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). Validated ... Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). Validated ...
more infohttps://www.lsbio.com/antibodies/cntn1-antibody-gp135-antibody-contactin-1-antibody-aa736-1003-pe-ihc-wb-western-ls-c723253/748683

Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1...Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1...

Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 ... Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 ...
more infohttps://jnnp.bmj.com/content/88/6/465.responses

Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA - RC214706 - 10 µg...Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA - RC214706 - 10 µg...

Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA - 10 µg - OriGene ... home , products , origene , myc-ddk-tagged orf clone of homo sapiens contactin 1 (cntn1), transcript variant 1 as transfection- ... Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA - RC214706 - 10 µg ... TrueORF Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA ...
more infohttps://www.bioscience.co.uk/product~161385

Contactin-associated protein 1 (IPR028872) | InterPro | EMBL-EBIContactin-associated protein 1 (IPR028872) | InterPro | EMBL-EBI

In association with contactin, it may have a role in the signaling between axons and myelinating glial cells [PMID: 9118959, ... Contactin-associated protein 1 (also known as paranodin or caspr1) has a key role in the formation of the paranodal junctions ... Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4- ... Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein ...
more infohttp://www.ebi.ac.uk/interpro/entry/IPR028872

TRIP Database - Contactin-1 / TRP channelsTRIP Database - Contactin-1 / TRP channels

Contactin-1. Yeast two-hybrid. Rat. 1-432. Human. Fetal brain. cDNA library. 17074976. ... Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo- ... suppl 1 (2011): D356-D361. *Young-Cheul Shin, Soo-Yong Shin, Jung Nyeo Chun, Hyeon Sung Cho, Jin Muk Lim, Hong-Gee Kim, Insuk ... Genet.. May 2000;25(1):25-9. World Wide Web URL: http://www.geneontology.org/ ...
more infohttp://trpchannel.org/proteins/show?id=Contactin-1

Porcine CNTN1 (Contactin 1) ELISA Kit  Manufacturers in DelhiPorcine CNTN1 (Contactin 1) ELISA Kit Manufacturers in Delhi

Contactin 1) ELISA Kit OSCAR DIAGNOSTIC SERVICES PVT. LTD.is an India based Company in Delhi. ... Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 (Contactin 1) ELISA Kit ... Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 ... Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 ...
more infohttps://www.odspl.com/sub-product/Porcine+CNTN1+%28Contactin+1%29+ELISA+Kit+.php

Rat CNTN1(Contactin 1) ELISA Kit - Rat CNTN1(Contactin 1) ELISA Kit Exporter, Importer, Manufacturer, Distributor, Supplier,...Rat CNTN1(Contactin 1) ELISA Kit - Rat CNTN1(Contactin 1) ELISA Kit Exporter, Importer, Manufacturer, Distributor, Supplier,...

Rat CYTH1(Cytohesin 1) ELISA Kit. *Rat DC-SIGN/CD209(DC Specific Intercellular Adhesion Molecule 3-Grabbing Nonintegrin) ELISA ... An unopened kit can be stored at 4 Æ for 1 month. If the kit is not used within 1 month, store the items separately according ... 1,3,4,6,7,8-Hexahydro-2h-pyrimido[1,2-a]pyrimidine, CAS Number: 5807-14-7,1g ... Boron trifluoride propanol complex, CAS Number: 762-48-1, 100g. *Boron trifluoride tetrahydrofuran complex, CAS Number: 462-34- ...
more infohttps://www.srgroupchemical.com/rat-cntn1-contactin-1-elisa-kit-4470093.html

Cntnap5a - Contactin-associated protein like 5-1 precursor - Rattus norvegicus (Rat) - Cntnap5a gene & proteinCntnap5a - Contactin-associated protein like 5-1 precursor - Rattus norvegicus (Rat) - Cntnap5a gene & protein

Contactin-associated protein like 5-1Add BLAST. 1281. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... sp,Q0V8T6,CTP5A_RAT Contactin-associated protein like 5-1 OS=Rattus norvegicus OX=10116 GN=Cntnap5a PE=2 SV=1 ... 1 - 24. Sequence analysisAdd BLAST. 24. ,p>This subsection of the PTM / Processing section describes the extent of a ... SSF56496 SSF56496, 1 hit. PROSITEi. View protein in PROSITE. PS50026 EGF_3, 2 hits. PS01285 FA58C_1, 1 hit. PS50022 FA58C_3 ...
more infohttps://www.uniprot.org/uniprot/Q0V8T6

F11 | definition of F11 by Medical dictionaryF11 | definition of F11 by Medical dictionary

contactin-1. (redirected from F11). Also found in: Acronyms, Wikipedia. contactin-1. A 130-kD glycoprotein cell adhesion ... Contactin-1 is differentially expressed in various neuronal tissues during development and interacts with several ligands-Nr- ... Sources pointed out CDA had built libraries and gyms in street No 58 sector I8/1, sector G8/2, sector F11 and sector G11 at ...
more infohttp://medical-dictionary.thefreedictionary.com/F11

The Evaluation of Efficacy and Safety of Rituximab in Refractory CIDP Patients With IgG4 Autoantibodies - Full Text View -...The Evaluation of Efficacy and Safety of Rituximab in Refractory CIDP Patients With IgG4 Autoantibodies - Full Text View -...

Contactin-1. Rituximab. Additional relevant MeSH terms:. Layout table for MeSH terms. ... Serum antibody titers of IgG4 (CNTN-1 and NF-155) and these IgG subclass [ Time Frame: Up to 52 weeks ]. Serum titers (CNTN-1 ... R-ODS is consist of a 24-item questionnaire about daily living task with 3 response options: (0) impossible to perform, (1) ... i) Patients with positive serum IgG4 autoantibody (CNTN-1 or NF-155) confirmed by the time of enrollment in the study ...
more infohttps://clinicaltrials.gov/ct2/show/NCT03864185?cond=%22Chronic+Inflammatory+Demyelinating+Polyneuritis%22&intr=%22Immunoglobulin+G%22&rank=1

کانتکتین ۱ - ویکی‌پدیا، دانشنامهٔ آزادکانتکتین ۱ - ویکی‌پدیا، دانشنامهٔ آزاد

کانتکتین ۱ (انگلیسی: Contactin 1) یک پروتئین است که در انسان توسط ژن «CNTN۱» کُدگذاری می‌شود. پروتئینی که توسط این ژن ساخته ... Contactin 1. ». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۸ آوریل ۲۰۱۸. ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ...
more infohttps://fa.wikipedia.org/wiki/%DA%A9%D8%A7%D9%86%D8%AA%DA%A9%D8%AA%DB%8C%D9%86_%DB%B1

CNTN1 - Wikipédia, a enciclopédia livreCNTN1 - Wikipédia, a enciclopédia livre

2001). «Contactin associates with Na+ channels and increases their functional expression.». J. Neurosci. 21 (19): 7517-25. PMID ... 2001). «Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent.». Eur. J. ... Berglund EO, Ranscht B (1994). «Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome ... Berglund EO, Ranscht B (1994). «Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome ...
more infohttps://pt.wikipedia.org/wiki/CNTN1

Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated...Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated...

Of the 19 patients with contactin-associated protein-antibody-2, 10 had neuromyotonia or Morvans syndrome, compared with only ... to contactin-associated protein-2 in 19 sera, to leucine-rich, glioma inactivated 1 protein in 55 sera and to contactin-2 in ... who all had contactin-associated-2 protein antibodies. This study confirms that the majority of patients with high potassium ... detection of contactin-associated protein-2 antibodies should help identify the risk of an underlying tumour and a poor ...
more infohttps://www.neuroscience.ox.ac.uk/publications/241453

KEGG PATHWAY: hsa04514KEGG PATHWAY: hsa04514

CNTN1; contactin 1 [KO:K06759]. 5797 PTPRM; protein tyrosine phosphatase, receptor type M [KO:K05693] [EC:3.1.3.48] ... Pathway (1) BioSystems (1) Disease (12) KEGG DISEASE (12) Genome (1) KEGG GENOME (1) Gene (145) KEGG GENES (145) All databases ... Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development. ... HLA-DPA1; major histocompatibility complex, class II, DP alpha 1 [KO:K06752] ...
more infohttp://www.genome.jp/dbget-bin/www_bget?pathway+hsa04514

Coagulation Factor VII Antibody [Unconjugated] (AF2338): Novus BiologicalsCoagulation Factor VII Antibody [Unconjugated] (AF2338): Novus Biologicals

Showing Publications 1 - 3 of 3.. Publications using AF2338. Applications. Species. Cherepanova N, Shrimal S, Gilmore R ... 1 month, 2 to 8 °C under sterile conditions after reconstitution.. *6 months, -20 to -70 °C under sterile conditions after ... The resulting 1:1 complex of VIIa and TF initiates the coagulation pathway and has also important coagulation-independent ... Coagulation Factors VII and VIIa refer to the pro and active forms of the same protease, respectively (1). Factor VII is ...
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Gene InfoGene Info

contactin 1. Protein Similarities Based on Shared Motif Content. Find gene products sharing protein motifs with: NP_778203 NP_ ...
more infohttps://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=143434&LLNO=1272

Coagulation Factor VII Antibody (321605) [Alexa Fluor® 350] (FAB23381U): Novus BiologicalsCoagulation Factor VII Antibody (321605) [Alexa Fluor® 350] (FAB23381U): Novus Biologicals

The resulting 1:1 complex of VIIa and TF initiates the coagulation pathway and has also important coagulation-independent ... Coagulation Factors VII and VIIa refer to the pro and active forms of the same protease, respectively (1). Factor VII is ... In direct ELISAs, no cross-reactivity with recombinant human (rh) Kallikrein‑1, -2, -3,. -4, -5, -7, -8, -9, -10, -11, -12, -13 ... Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells. ...
more infohttps://www.novusbio.com/products/coagulation-factor-vii-antibody-321605_fab23381u

Cntn1 monoclonal antibody, clone AR3 (ATTO 700) - (MAB11952) - Products - AbnovaCntn1 monoclonal antibody, clone AR3 (ATTO 700) - (MAB11952) - Products - Abnova

Immunohistochemistry (1:1000). Western Blot (1:1000). The optimal working dilution should be determined by the end user. ...
more infohttp://www.abnova.com/products/products_detail.asp?catalog_id=MAB11952

Cntn1 monoclonal antibody, clone S73-20 (HRP) - (MAB11957) - Products - AbnovaCntn1 monoclonal antibody, clone S73-20 (HRP) - (MAB11957) - Products - Abnova

Western Blot (1 ug/mL). Immunocytochemistry (0.1-1 ug/mL). Immunofluorescence (1-10 ug/mL). Immunohistochemistry (0.1-1 ug/mL) ...
more infohttp://www.abnova.com/products/products_detail.asp?catalog_id=MAB11957
  • Specificity of the autoantibodies was confirmed by immunoblot assay, binding to contactin-1-transfected human embryonic kidney cells, binding to paranodes of murine teased fibres and preabsorption experiments. (bmj.com)
  • In direct ELISAs and Western blots, approximately 15% cross-reactivity with recombinant mouse Coagulation Factor VII and less than 1% cross-reactivity with recombinant human Coagulation Factor XA is observed. (novusbio.com)
  • Loss of laminin alpha 1 results in multiple structural defects and divergent effects on adhesion during vertebrate optic cup morphogenesis. (semanticscholar.org)
  • Synthesized peptide derived from human Contactin 1. (lsbio.com)
  • The cleavage and activation of Coagulation Factors VII, IX, and X by VIIa:TF is phospholipid-dependent whereas the cleavage of small peptide substrates is not (1). (novusbio.com)
  • After a signal peptide (residues 1-38), the mature chain can be further processed into the light chain (residues 39-190) and the heavy chain (residues 191-444). (novusbio.com)
  • Most of the initially described anti-neural autoantibodies are directed against intracellular proteins like Hu, Yo, Ri, Ta, GAD, and amphiphysin ( 1 ). (frontiersin.org)
  • In association with contactin, it may have a role in the signaling between axons and myelinating glial cells [ PMID: 9118959 , PMID: 9292722 , PMID: 9396755 , PMID: 9786343 ]. (ebi.ac.uk)
  • Contactin 1 ) یک پروتئین است که در انسان توسط ژن « CNTN۱ » کُدگذاری می‌شود. (wikipedia.org)
  • Topographic restriction of TAG-1 expression in the developing retinotectal pathway and target dependent reexpression during axon regeneration. (semanticscholar.org)
  • Contactin-1 is differentially expressed in various neuronal tissues during development and interacts with several ligands-Nr-CAM, L1, NCAM, neurocan, phosphacan, and tenascin. (thefreedictionary.com)
  • An unopened kit can be stored at 4 Æ for 1 month. (srgroupchemical.com)
  • If the kit is not used within 1 month, store the items separately according to the following conditions once the kit is received. (srgroupchemical.com)
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution. (novusbio.com)
  • The resulting 1:1 complex of VIIa and TF initiates the coagulation pathway and has also important coagulation-independent functions such as angiognesis (2). (novusbio.com)