A contactin subtype that is predominantly expressed in the CEREBELLUM; HIPPOCAMPUS; NEOCORTEX; and HYPOTHALAMUS.
A family of immunoglobulin-related cell adhesion molecules that are involved in NERVOUS SYSTEM patterning.
A contactin subtype that plays a role in axon outgrowth, axon fasciculation, and neuronal migration.
Surface ligands that mediate cell-to-cell adhesion and function in the assembly and interconnection of the vertebrate nervous system. These molecules promote cell adhesion via a homophilic mechanism. These are not to be confused with NEURAL CELL ADHESION MOLECULES, now known to be expressed in a variety of tissues and cell types in addition to nervous tissue.
Regularly spaced gaps in the myelin sheaths of peripheral axons. Ranvier's nodes allow saltatory conduction, that is, jumping of impulses from node to node, which is faster and more energetically favorable than continuous conduction.
A voltage-gated sodium channel subtype that mediates the sodium ion permeability of excitable membranes. Defects in the SCN2A gene which codes for the alpha subunit of this sodium channel are associated with benign familial infantile seizures type 3, and early infantile epileptic encephalopathy type 11.
Hexameric extracellular matrix glycoprotein transiently expressed in many developing organs and often re-expressed in tumors. It is present in the central and peripheral nervous systems as well as in smooth muscle and tendons. (From Kreis & Vale, Guidebook to the Extracellular Matrix and Adhesion Proteins, 1993, p93)
A subclass of receptor-like protein tryosine phosphatases that contain an extracellular fibronectin III-like domain along with a carbonic anhydrase-like domain.
A voltage-gated sodium channel subtype found in neuronal tissue that mediates the sodium ion PERMEABILITY of excitable membranes.
A BRAIN-specific hyalectin that may play a role in terminally differentiating NEURONS. It is found highly overexpressed in primary BRAIN TUMORS and in experimental models of GLIOMA.
Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.
In tissue culture, hairlike projections of neurons stimulated by growth factors and other molecules. These projections may go on to form a branched tree of dendrites or a single axon or they may be reabsorbed at a later stage of development. "Neurite" may refer to any filamentous or pointed outgrowth of an embryonal or tissue-culture neural cell.
The lipid-rich sheath surrounding AXONS in both the CENTRAL NERVOUS SYSTEMS and PERIPHERAL NERVOUS SYSTEM. The myelin sheath is an electrical insulator and allows faster and more energetically efficient conduction of impulses. The sheath is formed by the cell membranes of glial cells (SCHWANN CELLS in the peripheral and OLIGODENDROGLIA in the central nervous system). Deterioration of the sheath in DEMYELINATING DISEASES is a serious clinical problem.
A compound that contains a reduced purine ring system but is not biosynthetically related to the purine alkaloids. It is a poison found in certain edible mollusks at certain times; elaborated by GONYAULAX and consumed by mollusks, fishes, etc. without ill effects. It is neurotoxic and causes RESPIRATORY PARALYSIS and other effects in MAMMALS, known as paralytic SHELLFISH poisoning.
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.
Ion channels that specifically allow the passage of SODIUM ions. A variety of specific sodium channel subtypes are involved in serving specialized functions such as neuronal signaling, CARDIAC MUSCLE contraction, and KIDNEY function.
The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
Surface ligands, usually glycoproteins, that mediate cell-to-cell adhesion. Their functions include the assembly and interconnection of various vertebrate systems, as well as maintenance of tissue integration, wound healing, morphogenic movements, cellular migrations, and metastasis.
Direct contact of a cell with a neighboring cell. Most such junctions are too small to be resolved by light microscopy, but they can be visualized by conventional or freeze-fracture electron microscopy, both of which show that the interacting CELL MEMBRANE and often the underlying CYTOPLASM and the intervening EXTRACELLULAR SPACE are highly specialized in these regions. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p792)
A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.
The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the TRIGEMINAL GANGLION and project to the TRIGEMINAL NUCLEUS of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
A class of large neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal (not the same as SATELLITE CELLS, PERINEURONAL of GANGLIA) according to their location. They form the insulating MYELIN SHEATH of axons in the central nervous system.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.
Crystallizable fragments composed of the carboxy-terminal halves of both IMMUNOGLOBULIN HEAVY CHAINS linked to each other by disulfide bonds. Fc fragments contain the carboxy-terminal parts of the heavy chain constant regions that are responsible for the effector functions of an immunoglobulin (COMPLEMENT fixation, binding to the cell membrane via FC RECEPTORS, and placental transport). This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.
Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.
An enzyme group that specifically dephosphorylates phosphotyrosyl residues in selected proteins. Together with PROTEIN-TYROSINE KINASE, it regulates tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis.
Adherence of cells to surfaces or to other cells.
CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
A family of conserved cell surface receptors that contain EPIDERMAL GROWTH FACTOR repeats in their extracellular domain and ANKYRIN repeats in their cytoplasmic domains. The cytoplasmic domain of notch receptors is released upon ligand binding and translocates to the CELL NUCLEUS where it acts as transcription factor.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
An enzyme that catalyzes the conversion of UDP-galactose and N-acylsphingosine to D-galactosylceramide and UDP.
A slowly progressive autoimmune demyelinating disease of peripheral nerves and nerve roots. Clinical manifestations include weakness and sensory loss in the extremities and enlargement of peripheral nerves. The course may be relapsing-remitting or demonstrate a step-wise progression. Protein is usually elevated in the spinal fluid and cranial nerves are typically spared. GUILLAIN-BARRE SYNDROME features a relatively rapid progression of disease which distinguishes it from this condition. (Adams et al., Principles of Neurology, 6th ed, p1337)
Diseases characterized by injury or dysfunction involving multiple peripheral nerves and nerve roots. The process may primarily affect myelin or nerve axons. Two of the more common demyelinating forms are acute inflammatory polyradiculopathy (GUILLAIN-BARRE SYNDROME) and POLYRADICULONEUROPATHY, CHRONIC INFLAMMATORY DEMYELINATING. Polyradiculoneuritis refers to inflammation of multiple peripheral nerves and spinal nerve roots.
An acute inflammatory autoimmune neuritis caused by T cell- mediated cellular immune response directed towards peripheral myelin. Demyelination occurs in peripheral nerves and nerve roots. The process is often preceded by a viral or bacterial infection, surgery, immunization, lymphoma, or exposure to toxins. Common clinical manifestations include progressive weakness, loss of sensation, and loss of deep tendon reflexes. Weakness of respiratory muscles and autonomic dysfunction may occur. (From Adams et al., Principles of Neurology, 6th ed, pp1312-1314)
Diseases characterized by loss or dysfunction of myelin in the central or peripheral nervous system.
Cyclical movement of a body part that can represent either a physiologic process or a manifestation of disease. Intention or action tremor, a common manifestation of CEREBELLAR DISEASES, is aggravated by movement. In contrast, resting tremor is maximal when there is no attempt at voluntary movement, and occurs as a relatively frequent manifestation of PARKINSON DISEASE.
Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.
A medical specialty concerned with the study of the structures, functions, and diseases of the nervous system.
Diseases of multiple peripheral nerves simultaneously. Polyneuropathies usually are characterized by symmetrical, bilateral distal motor and sensory impairment with a graded increase in severity distally. The pathological processes affecting peripheral nerves include degeneration of the axon, myelin or both. The various forms of polyneuropathy are categorized by the type of nerve affected (e.g., sensory, motor, or autonomic), by the distribution of nerve injury (e.g., distal vs. proximal), by nerve component primarily affected (e.g., demyelinating vs. axonal), by etiology, or by pattern of inheritance.
A branch of the tibial nerve which supplies sensory innervation to parts of the lower leg and foot.
Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.

Selective alterations in biosynthetic and endocytic protein traffic in Madin-Darby canine kidney epithelial cells expressing mutants of the small GTPase Rac1. (1/25)

Madin-Darby canine kidney (MDCK) cells expressing constitutively active Rac1 (Rac1V12) accumulate a large central aggregate of membranes beneath the apical membrane that contains filamentous actin, Rac1V12, rab11, and the resident apical membrane protein GP-135. To examine the roles of Rac1 in membrane traffic and the formation of this aggregate, we analyzed endocytic and biosynthetic trafficking pathways in MDCK cells expressing Rac1V12 and dominant inactive Rac1 (Rac1N17). Rac1V12 expression decreased the rates of apical and basolateral endocytosis, whereas Rac1N17 expression increased those rates from both membrane domains. Basolateral-to-apical transcytosis of immunoglobulin A (IgA) (a ligand for the polymeric immunoglobulin receptor [pIgR]), apical recycling of pIgR-IgA, and accumulation of newly synthesized GP-135 at the apical plasma membrane were all decreased in cells expressing Rac1V12. These effects of Rac1V12 on trafficking pathways to the apical membrane were the result of the delivery and trapping of these proteins in the central aggregate. In contrast to abnormalities in apical trafficking events, basolateral recycling of transferrin, degradation of EGF internalized from the basolateral membrane, and delivery of newly synthesized pIgR from the Golgi to the basolateral membrane were all relatively unaffected by Rac1V12 expression. Rac1N17 expression had little or no effect on these postendocytic or biosynthetic trafficking pathways. These results show that in polarized MDCK cells activated Rac1 may regulate the rate of endocytosis from both membrane domains and that expression of dominant active Rac1V12 specifically alters postendocytic and biosynthetic membrane traffic directed to the apical, but not the basolateral, membrane.  (+info)

Transgenic mice expressing F3/contactin from the TAG-1 promoter exhibit developmentally regulated changes in the differentiation of cerebellar neurons. (2/25)

F3/contactin (CNTN1) and TAG-1 (CNTN2) are closely related axonal glycoproteins that are differentially regulated during development. In the cerebellar cortex TAG-1 is expressed first as granule cell progenitors differentiate in the premigratory zone of the external germinal layer. However, as these cells begin radial migration, TAG-1 is replaced by F3/contactin. To address the significance of this differential regulation, we have generated transgenic mice in which F3/contactin expression is driven by TAG-1 gene regulatory sequences, which results in premature expression of F3/contactin in granule cells. These animals (TAG/F3 mice) display a developmentally regulated cerebellar phenotype in which the size of the cerebellum is markedly reduced during the first two postnatal weeks but subsequently recovers. This is due in part to a reduction in the number of granule cells, most evident in the external germinal layer at postnatal day 3 and in the inner granular layer between postnatal days 8 and 11. The reduction in granule cell number is accompanied by a decrease in precursor granule cell proliferation at postnatal day 3, followed by an increase in the number of cycling cells at postnatal day 8. In the same developmental window the size of the molecular layer is markedly reduced and Purkinje cell dendrites fail to elaborate normally. These data are consistent with a model in which deployment of F3/contactin on granule cells affects proliferation and differentiation of these neurons as well as the differentiation of their synaptic partners, the Purkinje cells. Together, these findings indicate that precise spatio-temporal regulation of TAG-1 and F3/contactin expression is critical for normal cerebellar morphogenesis.  (+info)

Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma. (3/25)

Numerous genetic changes are associated with cancer cell metastasis and invasion. In search for key regulators of invasion and metastasis, a panel of lung cancer cell lines with different invasive ability was screened. The gene for contactin-1 was found to play an essential role in tumor invasion and metastasis. Suppression of contactin-1 expression abolished the ability of lung adenocarcinoma cells to invade Matrigel in vitro as well as the polymerization of filamentous-actin and the formation of focal adhesion structures. Furthermore, knockdown of contactin-1 resulted in extensive inhibition of tumor metastasis and in increased survival in an animal model. RhoA but not Cdc42 or Rac1 was found to serve a critical role in contactin-1-mediated invasion and metastasis. Contactin-1-specific RNA interference resulted in loss of metastatic and invasive capacity in both in vitro and in vivo models. This loss was overturned by constitutive expression of the active form of RhoA. Contactin-1 was differentially expressed in tumor tissues, and its expression correlated with tumor stage, lymph node metastasis, and patient survival. Contactin-1 is proposed to function importantly in the invasion and metastasis of lung adenocarcinoma cells via RhoA-mediated mechanisms.  (+info)

The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. (4/25)

Flt-4, a VEGF receptor, is activated by its specific ligand, VEGF-C. The resultant signaling pathway promotes angiogenesis and/or lymphangiogenesis. This report provides evidence that the VEGF-C/Flt-4 axis enhances cancer cell mobility and invasiveness and contributes to the promotion of cancer cell metastasis. VEGF-C/Flt-4-mediated invasion and metastasis of cancer cells were found to require upregulation of the neural cell adhesion molecule contactin-1 through activation of the Src-p38 MAPK-C/EBP-dependent pathway. Examination of tumor tissues from various types of cancers revealed high levels of Flt-4 and VEGF-C expression that correlated closely with clinical metastasis and patient survival. The VEGF-C/Flt-4 axis, through upregulation of contactin-1, may regulate the invasive capacity in different types of cancer cells.  (+info)

Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin. (5/25)

Post-Golgi to apical surface delivery in polarized epithelial cells requires the cytoplasmic dynein motor complex. However, the nature of dynein-cargo interactions and their underlying regulation are largely unknown. Previous studies have shown that the apical surface targeting of rhodopsin requires the dynein light chain, Tctex-1, which binds directly to both dynein intermediate chain (IC) and rhodopsin. In this report, we show that the S82E mutant of Tctex-1, which mimics Tctex-1 phosphorylated at serine 82, has a reduced affinity for dynein IC but not for rhodopsin. Velocity sedimentation experiments further suggest that S82E is not incorporated into the dynein complex. The dominant-negative effect of S82E causes rhodopsin mislocalization in polarized Madin-Darby canine kidney (MDCK) cells. The S82A mutant, which mimics dephosphorylated Tctex-1, can be incorporated into dynein complex but is impaired in its release. Expression of S82A also causes disruption of the apical localization of rhodopsin in MDCK cells. Taken together, these results suggest that the dynein complex disassembles to release cargo due to the specific phosphorylation of Tctex-1 at the S82 residue and that this process is critical for the apical delivery of membrane cargoes.  (+info)

Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. (6/25)

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Contactin-1 is a functional receptor for neuroregulatory chondroitin sulfate-E. (7/25)

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The protein tyrosine phosphatases PTPRZ and PTPRG bind to distinct members of the contactin family of neural recognition molecules. (8/25)

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Complete information for CNTN6 gene (Protein Coding), Contactin 6, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for CNTN2 gene (Protein Coding), Contactin 2, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
CNTN1 - CNTN1 (untagged)-ORIGENE UNIQUE VARIANT 1 of Human contactin 1 (CNTN1), available for purchase from OriGene - Your Gene Company.
Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. Mutations of
Contactin 1, Polyclonal, Invitrogen™ 100μL; Unconjugated Contactin 1, Polyclonal, Invitrogen™ Primary Antibodies Ci to Cx
Mouse monoclonal antibody raised aginst synthetic peptide of Cntn1. A synthetic peptide corresponding to amino acids of 21-37 at extracellular domain of rat Cntn1. (MAB11957) - Products - Abnova
Rabbit polyclonal antibody raised against recombinant CNTN1. Recombinant protein corresponding to amino acids of human CNTN1. (PAB23744) - Products - Abnova
کانتکتین ۱ (انگلیسی: Contactin 1) یک پروتئین است که در انسان توسط ژن «CNTN۱» کُدگذاری می‌شود. پروتئینی که توسط این ژن ساخته می‌شود، در واقع، عضوی از اَبَرخانوادهٔ ایمنوگلوبولین‌هاست.[۲][۳] کانتکتین ۱، یک پروتئین غشاء عصبی متصل به گلیکوزیل‌فسفاتیدیل‌اینوزیتول است که در اتصال سلولی نقش دارد. احتمال دارد این پروتئین در تشکیل اتصالات آکسونی در جریان رشد و تکامل دستگاه عصبی نقش داشته باشد. دو گونه پیرایش آران‌ای مختلف برای این ژن یافت شده‌است که ایزوفرم‌های پروتئینی مختلفی را می‌سازند.[۳] ...
CNTN6 Polyclonal Antibody (CAB14275)OverviewTitle:CNTN6 Polyclonal Antibody (CAB14275)Size:100µLCode:CAB14275Host Species:RabbitPurification:Affinity purificationIsotype:IgGBackgroundThe protein encoded by this gene is a member of the immunoglobulin ...
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Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Th TNR CN-GM. FCT: Trp ∓ Kll fld bcs cts cnnt b trppd fstr thn th xpnntll brd t f cntrl.. FCT: Trp ∓ Strlz (TNR) s n vn bggr bjct flr bcs ths mn-md clgcl dsstrs cnnt b trppd fstr thn th xpnntll brd t f cntrl, nd th ls cntn th crll nnhlt ll ntv wldlf (frm th smllst f pr p t th tp prdtrs tht r strvd t dth), nd th cts cntn t sprd mn ddl dsss tht th crr td - FR WHCH THR R N VCCNS GNST THM. Mn f whch r vn lstd s btrrrsm gnts. (Sch s Tlrm nd Th Plg - s, ppl hv lrd dd frm ct-trnsmttd plg n th S. N fls nr rts vn rqrd. Th cts thmslvs crr nd trnsmt th plg ll n thr wn.). FCT: THR S BSLTL _NTHNG_ HMN BT TNR. Nrl vr lst TNRd ct ds n nhmn dth b rd-kll, frm ct nd nml ttcks, nvrnmntl psns, strvtn, dhdrtn, frzng t dth, nfctns, prsts, tc. nd f vr vr lck hmnl sht t dth r r-trppd nd drwnd (th tw mst cmmn mthds mpld n ll frms nd rnchs t prtct thr gsttng lvstcks ffsprng nd vlbl ntv wldlf dng frm cts Txplsmss prsts). Ths dsnt bgn t cnt th thsnds f dfnslss ntv nmls tht cts skn lv nd dsmbwl lv fr thr dl nd hrl ...
Invitrogen Anti-Contactin 5 Polyclonal, Catalog # PA5-58814. Tested in Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC) and Immunohistochemistry (IHC) applications. This antibody reacts with Human samples. Supplied as 100 µL purified antibody (0.2 mg/mL).
View mouse Cntnap4 Chr8:112570043-112882717 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Shop a large selection of products and learn more about PTPRZ, Polyclonal, Invitrogen 50µg; Unconjugated 50µg; Unconjugated.
tdn yrslf ths tm PZ, rlly? Y hv n grsp n hw th lgl systm wrks n ths cntry thr? nncnt ntl prvn glty. Shw prf r STF. gss w dd bsc lw t th lst lng wth skptcsm f thngs y knw jck sht bt. Y knw wh shckfgd s PZ? Y rmnd m f hm wth yr sht. H t wld mk ths knds f clms bt rlgn nd nvr hv bt f vdnc. Y r pthtc. dnt knw wht gv y th brght d tht sggstng ws glty f dntty thft ws gd d bt cn ssr y, t wsnt. m nt gng t pll sm lm stnt lk y dscrb hr, thr s n pnt n t. Wht m gng t cntn t d s pnt t yr lck f cmmn sns nd rdcl y bcs y dsrv t. Y spk f cwrdc whl y pst blgs bt m nd prdly cckl bt hw y wll nt llw m t dfnd myslf. Y r th cwrd y npt fl. Y bnd nd gg yr ppnnt thn prdly brg bt hw y cn kck thr ss. Ww th sprr ntllct rlly s w nsprng PZ. Wh d y thnk s mprssd? Why d y nd s bdly t mprss nyn? s yr vl slf wrth rlly s lw?Th sd thng s y r nly hrtng yrslf, th nly ppl wh fll fr yr lttl gms r ll jst s blnd s y t wht bng skptcl s. knw y r md t m PZ, nd y r gng t b vn mr pst m frd bcs y r jst t dmn dmb t lrn hw t sht p. dnt nd t ...
Expresses the extracellular region of the Contactin 5, isoform 1 protein (truncated immediately upstream of propeptide cleavage and GPI-attachement site), C-terminally fused to the Fc region of human IgG1 + 6X histidine tag ...
Yoshihara Y, Kawasaki M, Tamada A; et al. (1996). «Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily.». J. Neurobiol. 28 (1): 51-69. PMID 8586965. doi:10.1002/neu.480280106 ...
Two experiments were carried out to address the question of whether PTPα and contactin associate in a cis or trans conformation. First, anticontactin precipitates were prepared from lysates of COS cells expressing either PTPα or contactin, or from cells coexpressing both PTPα and contactin ( Fig. 5 A, lanes 1-3), as well as from another sample made by mixing lysates from the cells expressing either contactin or PTPα ( Fig. 5 A, lane 4). Anticontactin immunoprecipitates prepared from coexpressing cells contained PTPα, but those from mixed cell lysates did not ( Fig. 5 A, bottom, lanes 7 and 8). The lack of detectable association of PTPα and contactin in the mixed lysates suggests that interaction cannot take place in a trans conformation. Still, this may require a particular presentation of these cell surface molecules in growing cells that cannot form in solubilized cell lysates. Therefore, contactin-expressing cells were trypsinized 24 h after transfection and replated in dishes ...
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis.
Expression of CNTN2 (AXT, TAG-1, TAX, TAX1) in tonsil tissue. Antibody staining with HPA001397 and HPA012497 in immunohistochemistry.
Expression of CNTN2 (AXT, TAG-1, TAX, TAX1) in epididymis tissue. Antibody staining with HPA001397 and HPA012497 in immunohistochemistry.
Contactin 6 / NB-3 (mouse aa160-172) Antibody (internal region), Peptide-affinity purified goat antibody validated in E (AF3868a), Abgent
TY - JOUR. T1 - A synthetic peptide derived from the sequence of a type I collagen receptor inhibits type I collagen-mediated platelet aggregation. AU - Chiang, Thomas M.. AU - Kang, Andrew. PY - 1997/10/15. Y1 - 1997/10/15. N2 - A synthetic peptide-1, an 18 amino acid residue peptide derived from a hydrophilic domain of a cloned platelet type I collagen receptor, was used to study the role of the receptor on types I and III collagen-induced platelet aggregation and the release of ATP. The peptide inhibits the type I, but not the type III, collagen-induced platelet aggregation and the release of ATP in a dose-dependent manner. The [125I]peptide-1 specifically binds to type I collagen-coated microtiter wells in a dose-dependent manner (with K(d) = 10 nM). The binding of [125I]peptide-1 can be inhibited by an excess of unlabeled peptide-1 suggesting that the binding is specific. The labeled peptide-1 does not bind to type III collagen-coated microtiter wells. Results from an enzyme-linked ...
FIG. 3. Distribution of contactin protein in stage 37/8 embryos, visualized by whole-mount immunocytochemistry. (A) A lateral view of the anterior 2/3 of the stained embryo, showing nervous tissue-specific distribution of contactin immunoreactivity. (B) An enlarged dorsal view of the brain portion of the embryo shown in (A). Axon tracts in the brain and primary olfactory region (arrowhead) are contactin positive. (C, D, and G) Cross sections of the stained embryo at the levels of midbrain (C), hindbrain (D), and posterior spinal cord (G). Contactin is expressed in the postoptic commissure and the optic chiasm of the lateral diencephalon (arrowheads in C) and the fasciculus longitudinalis medialis in the ventral marginal region (arrowheads in D). (E and F) Enlarged lateral (E) and dorsal (F) views of a part of the embryos, showing contactin-positive dorsal and ventral spinal fascicles. An arrow and an arrowhead in (E) represent contactin-positive cell bodies of a RB neuron and an EM neuron, ...
The aim of this study was to investigate the potential of cell-free DNA (cfDNA) as a disease biomarker in oesophageal squamous cell carcinoma (ESCC) that can be used for treatment response evaluation and early detection of tumour recurrence. Matched tumour tissue, pre- and post-surgery plasma and WBCs obtained from 17 ESCC patients were sequenced using a panel of 483 cancer-related genes. Somatic mutations were detected in 14 of 17 tumour tissues. Putative harmful mutations were observed in genes involved in well-known cancer-related pathways, including PI3K-Akt/mTOR signalling, Proteoglycans in cancer, FoxO signalling, Jak-STAT signalling, Chemokine signalling and Focal adhesion. Forty-six somatic mutations were found in pre-surgery cfDNA in 8 of 12 patients, with mutant allele frequencies (MAF) ranging from 0.24 to 4.91%. Three of the 8 patients with detectable circulating tumour DNA (ctDNA) had stage IIA disease, whereas the others had stage IIB-IIIB disease. Post-surgery cfDNA somatic mutations were
MicroRNA Polymorphisms and Environmental Smoke Exposure as Risk Factors for Oesophageal Squamous Cell Carcinoma. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Golgi analyses showed abnormal dendritic arborisation of hippocampal CA1 neurons and an increased hippocampal volume. Furthermore, it was also investigated whether these changes correlated with deficits in learning and memory behaviour. For that purpose, short- and long-term recognition memory, spatial memory and fear conditioning responses were assessed. These behavioural studies showed increased contextual fear conditioning in heterozygous and homozygous KO mice, quantified by a gene-dose dependent increase in freezing response. In comparison to wild-type mice, Cntn4-deficient animals froze significantly less and groomed more, indicative of increased stress responsiveness under the test conditions. In addition, we tested if Cntn4 gene expression affects CA1 synaptic transmission and the ability to induce LTP in hippocampal slices. Stimulation in CA1 stratum radiatum with 900 pulses at 10 Hz and 1 pulse at 100 Hz decreased significant synaptic potentiation in Cntn4 KO mice. Our neuro-anatomical ...
Mice homozygous for the recessive buff (|i|Vps33a|sup|bf|/sup||/i|) mutation on a non-agouti (|i|a|/i|/|i|a|/i|) background have a lightened coat color that has been described as khaki. On an agouti background, |i|Vps33a|sup|bf|/sup||/i| homozygotes have dark ears, opaque eyes, and the belly is lighter in color than is the rest of the coat. Although no change in eye color is outwardly evident, electron microscopy shows fewer and smaller melanosomes than normal in the retinal pigment epithelium and choroid. These mutants have a platelet-storage pool defect evidenced by an increased bleeding time of 9.7 minutes on average, a reduction in the number of platelet dense granules, and slightly decreased collagen-mediated platelet aggregation, secretion of dense-granule ATP and secretion of seratonin. Hakansson and Lundin found increased activity of the lysosomal glycosidases beta- galactosidase, beta-glucuronidase, and N-acetyl-beta-hexosaminidase in kidney cell lysates. Suzuki |i|et al.|/i| found no
We use a single molecule atomic force spectroscopy combined with the steered molecular dynamics simulation to determine a mechanical behavior of neural cell adhesion protein contactin during its unfolding. Force curves typical for modular proteins were observed, showing at most four unfolding peaks. The analysis of force spectra performed within worm-like chain model of polymer elasticity showed the presence of three unfolding lengths. Small plateaus, most likely resulting from forced transitions within domains were observed for the first time. Steered molecular dynamics simulations help to determine atomistic picture of domain unfolding ...
TABLE-US-00004 TABLE 4 Cell and biological adhesion Fold Symbol Gene name Gene assignment change CLDN7 claudin 7 Involved in the formation of 2.74 tight junctions between epithelial cells PCDHB5 Protocadherin Member of the 3.32 beta-5 protocadherin beta gene cluster CLDN3 Claudin 3 Member of the claudin 3.93 family, is an integral membrane protein and a component of tight junction strands. CNTN6 contactin 6 Contactins mediate cell 3.09 surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. PKHD1 polycystic kidney Localized predominantly at 3.38 and hepatic the disease 1 apical domain of polarized epithelial cells, suggesting it may be involved in the tubulogenesis and/or maintenance of duct-lumen architecture. PCDHB2 protocadherin The extracellular domains 2.94 beta 2 interact in a homophilic manner to specify differential cell-cell connections. CDH1 E-cadherin cell adhesion molecule 3.27 (epithelial) CX3CL1 hemokine ...
Several reports have pointed out that the ECM inhibits regeneration and suppresses plasticity in the adult CNS (Berardi et al., 2004; Fitch and Silver, 2008; Gervasi et al., 2008). By comparison, the role of the ECM in the stem and precursor cell microenvironment remains obscure, although the cellular microenvironment is crucial for stem cell maintenance and self-renewal (Scadden, 2006). Focusing on OPCs as a model, we reveal an inhibitory function of the ECM glycoprotein Tnc on differentiation and disentangle molecular details of ECM pathways designed to suppress the differentiation of a committed neural precursor cell. We show that Tnc suppresses the expression of MBP in oligodendrocytes both in vitro and in vivo during postnatal forebrain development, confirming its biological significance. The underlying signaling cascade requires the cell surface receptor Cntn1 and the associated Fyn kinase, and involves the regulation of the signaling adaptor and splice regulator Sam68. We further document ...
Background The aetiological role of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) has been widely researched for more than three decades, with conflicting findings. In the absence of a large, adequately powered single case-control study, a meta-analysis of all available case-control studies is the most rigorous way of identifying any potential association between HPV and OSCC. We present the first global meta-analysis of case-control studies investigating the role of HPV in OSCC. Methods Case-control studies investigating OSCC tissue for presence of HPV DNA were identified. 21 case-control studies analyzing a total of 1223 cases and 1415 controls, met our inclusion criteria. HPV detection rates were tabulated for each study and all studies were assessed for quality. The random effects method was used to pool the odds ratios (OR). Results From all OSCC specimens included in this meta-analysis, 35% (426/1223) were positive for HPV DNA. The pooled OR for an HPV-OSCC association
BACKGROUND: A neuroinflammatory response is suggested to play an important role in delirium, a common complication in older hospitalized patients. We examined whether hip fracture patients who develop postoperative delirium have a different proteome in cerebrospinal fluid (CSF) prior to surgery. METHODS: Patients (≥ 75 years) were admitted for hip ... read more fracture surgery. CSF was collected during spinal anaesthesia; proteins were separated using gel electrophoresis and identified with mass spectrometry. We compared the proteome of patients with and without postoperative delirium. Findings were validated in an independent, comparable cohort using immuno-assays. RESULTS: In the derivation cohort 53 patients were included, 35.8% developed postoperative delirium. We identified differences in levels of eight CSF proteins between patients with and without subsequent delirium: complement factor C3, contactin-1, fibulin-1 and I-beta-1,3-N-acetylglucosaminyltransferase were significantly lower ...
A 20-month-old boy - offspring of consanguinous parents, whose mother presumably had subclinical myopathy - presented with clinical signs of congenital non-progressive myopathy, neurogenic-myogenic...
A new technically suitable feature regarding gliomas will be the really infiltrative development style. Hence, PTPs which are regarded or believed to be linked to adhesion along with migration connected with cellular material have earned particular attention. Several of your PTP genes that show transformed concept stages in the extremely dangerous GBM subtype have already been linked to cellular bond: PTPRD, PTPRM plus DUSP26. Additionally, PTPRZ, DUSP1, PTP4A3 and also CDKN3, just about all suggested as a factor Calcitriol inside management of cell phone migration, exhibit aberrant term quantities with GBM specimens. It can be appealing to invest these particular variations help with the glues as well as migratory modifications with glioma cellular material. Confounding issues around glioma exploration At this point, the attained advice about your molecular elements underlying gliomagenesis hasnt but resulted in significantly improved remedy techniques for GBM clients. Various motives may be ...
Cells may be positioned in precise, predetermined patterns by a technique, termed cytoscribing, in which cell adhesion proteins are deposited on a substratum under computer control. Using standard office equipment, cells may be positioned within a cell diameter with the techniques described. Cytoscr …
A genetic defect causing autism and epilepsy involving the contactin associatedprotein-like 2 gene (CNTNAP2) has been discovered in a selected cohort of Amishchildren. These children were found to have focal seizures and autisticregression. Surgical biopsy of the anterior temporal lobe of two such childrenrevealed cortical dysplasia and a single nucleotide polymorphismmutation of this gene. The present case is that of a related but geographically distant probandwith a similar phenotype but a single-base-pair deletion in the CNTNAP2 gene.This patient exhibited the additional features of periventricular leukomalaciaand hepatomegaly ...
Oesophageal cancer has a high metastatic potential and poor prognosis, with a significant risk of recurrence after radical resection. However, resected pancreatic metastasis from oesophageal cancer is rare. Eleven years prior, a seventy-year-old woman had been treated with transthoracic radical oesophagectomy for oesophageal squamous cell carcinoma. Four years prior, she had undergone chemotherapy for lymph node recurrence at the splenic hilum and achieved a partial response. She had also received chemoradiotherapy for lymph node recurrence at the splenic hilum 3 years prior; a complete response was achieved. However, routine follow-up with abdominal computed tomography recently revealed a tumour at the pancreatic tail and swollen lymph nodes. The patient underwent distal pancreatectomy on the basis of a pre-operative diagnosis of primary pancreatic cancer, although a histological examination of the surgical specimen revealed metastatic squamous cell carcinoma that was compatible with metachronous
Oesophageal Squamous Cell Carcinoma African Prevention Research (ESCCAPE): a collaborative research effort to investigate the etiological epidemiology of squamous cell oesophageal carcinoma in the high-incidence belt in East Africa; major case-control studies are ongoing in Eldoret (Kenya), in Moshi, Kilimanjaro (the United Republic of Tanzania), and in Blantyre (Malawi) with further pilot work being conducted in Ethiopia (http://esccape.iarc.fr ...
Design The authors used transgenic mice in which the Hh receptor Patched1 (Ptch1) could be conditionally inactivated in a body-wide manner and mice in which Gli1 could be induced specifically in the epithelium of the skin and oesophagus. Effects on epithelial homeostasis of the oesophagus were examined using immunohistochemistry, in situ hybridisation, transmission electron microscopy and real-time PCR. Hh signalling was examined in patients with oesophageal squamous cell carcinoma (SCC) by quantitative real-time PCR.. ...
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Results High reactivity to contactin-1 by ELISA was found in four patients with chronic inflammatory demyelinating polyradiculoneuropathy and in none of the patients with Guillain-Barré syndrome, which was confirmed by cell binding assays in all four patients. The four patients presented with a typical clinical picture, namely acute onset of disease and severe motor symptoms, with three patients manifesting action tremor. Immunofluorescence-labelling of paranodal proteins of dermal myelinated fibres revealed disruption of paranodal architecture. Semithin sections showed axonal damage but no classical signs of demyelination. ...
PTPRG (protein tyrosine phosphatase, receptor type, G), Authors: Cornelis P Tensen, Remco van Doorn. Published in: Atlas Genet Cytogenet Oncol Haematol.
Fungus Mrc1 ortholog of metazoan Claspin is normally both a central element of regular DNA replication forks and a mediator from the S phase checkpoint. replication devices should be sequentially set up and specifically programmed in a way that S stage is normally appropriately built-into the cell routine. Development and Set up take place through the M/G1 stages from the cell routine. Furthermore the replication devices must be covered during S stage because progress from the replication machine along the template while sequential isnt constant. Replication forks stall regularly either Rabbit Polyclonal to CNTN2. in difficult-to-replicate parts of the genome or because of exogenous environmental disturbance. Preventing replication forks from irreversibly collapsing in S stage when de novo set ML 786 dihydrochloride up is normally no longer allowed becomes a remarkable question. Cells will need to have a system to stabilize the replication equipment in situ until aberrant buildings can be taken ...
... such as tenascin R and the cell-adhesion molecules neurofascin and contactin. Contactin is also present at nodes in the CNS and ... At CNS nodes, the axonal proteins also include contactin; however, Schwann cell microvilli are replaced by astrocyte perinodal ... The size of the nodes span from 1-2 μm whereas the internodes can be up to (and occasionally even greater than)1.5 millimetres ... 30 (1): 91-104. doi:10.1016/S0896-6273(01)00265-3. PMID 11343647. S2CID 7168889.[permanent dead link] Lambert S, Davis JQ, ...
Contactin-associated protein-like 2 is a protein that in humans is encoded by the CNTNAP2 gene. Since the most recent reference ... "Entrez Gene: CNTNAP2 contactin associated protein-like 2". Ashley, Euan A. (16 August 2016). "Towards precision medicine". ... Nakabayashi K, Scherer SW (April 2001). "The human contactin-associated protein-like 2 gene (CNTNAP2) spans over 2 Mb of DNA at ... Overview of all the structural information available in the PDB for UniProt: Q9UHC6 (Contactin-associated protein-like 2) at ...
... members also bind "heterophilically" to members of the contactin or CNTN1 family. L1 family members bind to many ... doi:10.1007/978-1-4614-8090-7_9. PMID 25300138. Wei CH, Ryu SE (July 2012). "Homophilic interaction of the L1 family of cell ... NrCAM and neurofascin both have class 1 PDZ domain binding motifs at their COOH termini. NrCAM can bind to SAP102 and other ...
"Contactin-Associated Protein (Caspr) and Contactin Form a Complex That Is Targeted to the Paranodal Junctions during ... CASPR also known as Contactin associated protein 1, Paranodin and CASPR1 is a protein that in humans is encoded by the CNTNAP1 ... The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino ... "Entrez Gene: Contactin associated protein 1". "OMIM Entry- * 602346 - CONTACTIN-ASSOCIATED PROTEIN 1; CNTNAP1". omim.org. ...
This extracellular region is similar to the cell adhesion molecule contactin and other cell adhesion molecules. It is believed ... GEFS+ type 1 is a subtype of GEFS+ in which there are mutations in SCN1B, a gene encoding a sodium channel β subunit. The β ... 116 (1): 37-48. doi:10.1016/S0306-4522(02)00698-X. PMID 12535936. Singh R, Andermann E, Whitehouse W, Harvey A, Keene D, Seni M ... 53 (1-2): 107-17. doi:10.1016/S0920-1211(02)00259-0. PMID 12576172. Barela A, Waddy S, Lickfett J, Hunter J, Anido A, Helmers S ...
Contactin, also known as F3 or F11, associates with beta 1 as shown via co-immunoprecipitation. Fibronectin-like (FN-like) ... Shah BS, Rush AM, Liu S, Tyrrell L, Black JA, Dib-Hajj SD, Waxman SG (August 2004). "Contactin associates with sodium channel ... "Contactin associates with Na+ channels and increases their functional expression". The Journal of Neuroscience. 21 (19): 7517- ... 26 (1): 13-25. doi:10.1016/S0896-6273(00)81133-2. PMID 10798388. S2CID 17928749. Isom LL, De Jongh KS, Patton DE, Reber BF, ...
5 had antibodies against Contactin-2 and 18 (19%) had antibodies with unknown specificity. Of the patients with Contactin-2 ... 19 had antibodies reacting with Contactin-associated protein 2 (CASPR 2), ... anti-LGI-1 encephalitis: Patients with anti-LGI1 encephalitis have limbic encephalitis with amnesia and/or confusion (100%) and ... The number of patients with anti-LGI1 antibodies and tumours have been reported to be between 0 and 11% in anti-LGI-1 antibody ...
Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene. This gene product belongs to ... "Entrez Gene: CNTNAP4 contactin associated protein-like 4". Human CNTNAP4 genome location and CNTNAP4 gene details page in the ... 16 (1): 55-65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial ...
Schuko is an abbreviation for the German word Schutzkontakt, which means "Protective contact" - in this case "protective" ... CEE 7/1 wall socket, accepts CEE 7/2 (unearthed) plug and also CEE 7/4, CEE 7/6 and CEE 7/7 (earthed) plugs Power bar with CEE ... CEE 7/1 sockets accept CEE 7/4, CEE 7/6 and CEE 7/7 plugs without providing an earth connection. The earthed CEE 7/3 and CEE 7/ ... CEE 7/1 and CEE 7/4 are still occasionally found in less used areas of some older homes, particularly in outbuildings or hot ...
... contactin associated protein 1 (CASPR1) and gliomedin. All of them nodal and paranodal proteins. Several anti-TNF drugs like ... 60 (1): 27-30. doi:10.1136/jnnp.60.1.27. PMC 486185. PMID 8558146. Li R, Patterson KR, Bar-Or A (2018). "Reassessing B cell ... 182 (1): 195-9. doi:10.2214/ajr.182.1.1820195. PMID 14684539. Reindl M; Di Pauli F; Rostásy K; Berger T (August 2013). "The ... ISBN 978-1-85317-506-0. Hartung HP, Grossman RI (May 2001). "ADEM: distinct disease or part of the MS spectrum?". Neurology. 56 ...
Autoantibodies to components of the Ranvier nodes, specially autoantibodies the Contactin-associated protein 1 (CASPR), cause a ... contactin-1 and caspr-1. These cases are special not only because of their pathology, but also because they are non-responsive ... 129 (1): 232-237. doi:10.1016/j.clinph.2017.10.040. PMID 29202391. S2CID 24416887. Goedee, H. Stephan; van der Pol, W. Ludo; ... 115 (1-2): 4-18. doi:10.1016/S0165-5728(01)00266-1. PMC 1073940. PMID 11282149. van Doorn, Pieter A.; Garssen, Marcel P.J. ( ...
Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: ... 69 (1): 113-9. doi:10.1006/geno.2000.6310. PMID 11013081. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. ( ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Padilla PI, Pacheco-Rodriguez G, Moss J, Vaughan M (Mar 2004). "Nuclear ... Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene. ADP- ...
... contactin 1 (CNTN1), contactin associated protein 1 (CASPR1) and gliomedin. All of them nodal and paranodal proteins. Anti-TNF ... 26 (1): 27-40. doi:10.1111/ene.13819. PMID 30300457. Lublin, F. D.; Reingold, S. C.; Cohen, J. A.; Cutter, G. R.; Sorensen, P. ... 286 (1-2): 99-103. doi:10.1016/j.jns.2009.05.028. PMC 2760629. PMID 19539954. Voskuhl, Rhonda R; Wang, HeJing; Wu, T C Jackson ... 266 (1-2): 25-30. doi:10.1016/j.jns.2007.08.023. PMID 17870094. S2CID 24283817. Krishnan C, Kaplin AI, Brodsky RA, et al. (June ...
Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K (Oct 2000). "Human NB-2 of the contactin subgroup molecules: ... 36 (1): 69-76. doi:10.1038/ng1276. PMID 14647276. Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, ... 69 (1): 113-9. doi:10.1006/geno.2000.6310. PMID 11013081. Pacheco-Rodriguez G, Moss J, Vaughan M (2002). "BIG1 and BIG2: ... Kuroda F, Moss J, Vaughan M (Feb 2007). "Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and ...
Shah BS, Rush AM, Liu S, Tyrrell L, Black JA, Dib-Hajj SD, Waxman SG (August 2004). "Contactin associates with sodium channel ... 264 (1): 113-22. doi:10.1016/S0378-1119(00)00594-1. PMID 11245985. Whitaker WR, Faull RL, Dragunow M, Mee EW, Emson PC, Clare ... 10 (1): 67-70. doi:10.1007/BF02737087. PMID 9589372. S2CID 2533542. Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O ( ... 7 (1): 65-73. doi:10.1093/dnares/7.1.65. PMID 10718198. Gotthardt M, Trommsdorff M, Nevitt MF, Shelton J, Richardson JA, ...
... such as F3/contactin. In the nematode C. elegans, two genes encode homologous proteins, glp-1 and lin-12. There has been at ... 266 (1): 161-77. doi:10.1016/j.ydbio.2003.10.017. PMID 14729486. Huang EJ, Li H, Tang AA, Wiggins AK, Neve RL, Zhong W, Jan LY ... 23 (1): 14-25. doi:10.1128/MCB.23.1.14-25.2003. PMC 140667. PMID 12482957. Grego-Bessa J, Luna-Zurita L, del Monte G, Bolós V, ... Notch 1, for example, has 36 of these repeats. Each EGF-like repeat is composed of approximately 40 amino acids, and its ...
... beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Wang J, Robinson JF, O'Neil CH, et al. (2006). "Ankyrin G overexpression in ... 27 (1): 189-91. doi:10.1006/geno.1995.1023. PMID 7665168. Lambert S, Davis JQ, Bennett V (September 1997). "Morphogenesis of ... 78 (1): 78-88. doi:10.1086/498851. PMC 1380225. PMID 16385451. Stabach PR, Devarajan P, Stankewich MC, et al. (2008). "Ankyrin ...
CNTN4: Contactin 4. *COL7A1: Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) ... 978-1-136-84407-2. .. *^ a b c Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). ... SFMBT1: Scm-like with four mbt domains 1. *SLC25A20: solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 ... TRAK1: trafficking kinesin-binding protein 1. *TRANK1: encoding protein Tetratricopeptide repeat and ankyrin repeat containing ...
... as well as the neuronal molecules contactin and Thy-1 (CD90). Quite surprisingly, the alpha toxin of C. septicum is not related ... 66 (1): 63-66. doi:10.1016/0002-9343(79)90483-2. PMID 420252. Liechti, ME; Schob, O; Kacl, GM; Caduff, B (2003). "Clostridium ... 4 (4): 1-9. doi:10.1371/journal.ppat.1000045. PMC 2275794. PMID 18404211. Ballard, J; Bryant, A; Stevens, D; Tweten, RK (1992 ... 63 (1): 340-344. doi:10.1128/IAI.63.1.340-344.1995. PMC 172997. PMID 7806374. Melton-Witt, JA; Bensten, LM; Tweten, RK (2006 ...
1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine ... 12 (1): 1-10. doi:10.1017/S1461145708009127. PMID 18664314. Grumet M (1997). "Nr-CAM: a cell adhesion molecule with ligand and ... 154 (1): 187-96. doi:10.1083/jcb.200104038. PMC 2196853. PMID 11449000. Dry K, Kenwrick S, Rosenthal A, Platzer M (2001). "The ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Hutcheson HB, Olson LM, Bradford Y, et al. (2004). "Examination of NRCAM, ...
Leucine-rich, glioma inactivated 1, also known as LGI1, is a protein which in humans is encoded by the LGI1 gene. It may be a ... 10 (1): 56-60. doi:10.1038/ng0595-56. PMC 2823475. PMID 7647791. Wilson MH, Puranam RS, Ottman R, Gilliam C, Limbird LE, George ... 51 (6): 1730-1. doi:10.1212/wnl.51.6.1730. PMID 9855534. S2CID 85601127. Kalachikov S, Evgrafov O, Ross B, Winawer M, Barker- ... The leucine-rich glioma inactivated -1 gene is rearranged as a result of translocations in glioblastoma cell lines. The protein ...
2001). «Contactin associates with Na+ channels and increases their functional expression.». J. Neurosci. 21 (19): 7517-25. PMID ... 2001). «Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent.». Eur. J. ... Berglund EO, Ranscht B (1994). «Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome ... Berglund EO, Ranscht B (1994). «Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome ...
کانتکتین ۱ (انگلیسی: Contactin 1) یک پروتئین است که در انسان توسط ژن «CNTN۱» کُدگذاری می‌شود. پروتئینی که توسط این ژن ساخته ... Contactin 1. ». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۸ آوریل ۲۰۱۸. ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ...
A Pitt-Hopkins-like phenotype has been assigned to autosomal recessive mutations of the contactin associated protein like 2 ( ... CNTNAP2) gene on the long arm of chromosome 7 (7q33-q36) and the neurexin 1 alpha (NRXN1) gene on the short arm of chromosome 2 ...
Contactin 4 COL7A1: Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) CRBN: Cereblon ... ISBN 978-1-136-84407-2. Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). Last ... ISBN 978-1-4673-1921-8. S2CID 16666470. "p": Short arm; "q": Long arm. For cytogenetic banding nomenclature, see article locus ... Partial list of the genes located on p-arm (short arm) of human chromosome 3: ALAS1: aminolevulinate, delta-, synthase 1 APEH: ...
... www.bbspy.co.uk/cbb11/news/0123/more-outside-contact-in-viewers-venom-task-opinions-celeb-bb-2013 [2] "Vanessa Feltz, Danielle ... 1][dead link] Harp, Justin (25 August 2012). "CBB: Jasmine Lennard's mum Marilyn fails secret task". Digital Spy. Retrieved 26 ... http://www.bbspy.co.uk/cbb11/news/0123/more-outside-contact-in-viewers-venom-task-opinions-celeb-bb-2013 http:// ... 1 September 2015. Retrieved 26 January 2016. "Day 7: Watch the sabotaged royal interview". Channel 5. 2 September 2015. ...
CONTACT- in-house magazine of OTC. Masterton, R and Prances M; Invisible Bridges, Australia and International ... 1 April: The first commercial use of Moree SES came on this day when news stations in Melbourne broadcast US President Lyndon ... 1 October: OTC and AWA Ltd signed a Caretaker and Management Agreement under which AWA continued to control and operate radio ... 1 April: Ownership and control of Cable and Wireless Ltd's assets in Australia passed to OTC. All staff except those hired ...
Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the ... The subgroup consists of six members now referred to as contactin 1-6, but historically they had different names as shown in ... "Contactins". Cell Adh Migr. 3 (1): 64-70. PMC 2675151. PMID 19262165. This set index page lists chemical compounds articles ... the table below: Shimoda, Yasushi; Watanabe, Kazutada (1 January 2009). " ...
Contactin-3 is a protein that in humans is encoded by the CNTN3 gene. GRCh38: Ensembl release 89: ENSG00000113805 - Ensembl, ... "Entrez Gene: CNTN3 contactin 3 (plasmacytoma associated)". Human CNTN3 genome location and CNTN3 gene details page in the UCSC ... 2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression ... 69 (1): 113-9. doi:10.1006/geno.2000.6310. PMID 11013081. Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the ...
... , also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene. The protein encoded by this gene ... "Entrez Gene: CNTN1 contactin 1". CS1 maint: discouraged parameter (link) Sakurai T, Lustig M, Nativ M, Hemperly JJ, ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ...
... to be a gas or aerosol providing a harmless way of rendering characters temporarily unconscious without physical contact - in ... 14-. ISBN 978-1-4772-7589-4. Cite error: The named reference Summary1958 was invoked but never defined (see the help page). ... At the time, the gas was reported to be an unknown incapacitating agent called "Kolokol-1". The Russian Health Minister Yuri ... Sharad S. Chauhan (January 1, 2004). Biological Weapons. APH Publishing. pp. 121-. ISBN 978-81-7648-732-0. Hersh, Seymour (1967 ...
Schuko is an abbreviation for the German word Schutzkontakt, which means "Protective contact" - in this case "protective" ... IEC 60884-1 ed3.2, Plugs and socket-outlets for household and similar purposes - Part 1: General requirements, CH: ... 1 August 2011. Retrieved 2017-05-26.. *^ "Einsatzende der Steckdosen Typ 12" (PDF) (official journal). Bulletin Electrosuisse/ ... CEE 7/1 socket & CEE 7/2 plug. 10 A. 16 A. 250 V. No[d]. No. No. No. Yes. ...
... beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ... 81 (1-2): 187-90. doi:10.1016/S0169-328X(00)00145-5. PMID 11000491. Kasai N, Fukushima K, Ueki Y, et al. (2001). "Genomic ... 303 (1): 53-8. doi:10.1016/0014-5793(92)80476-W. PMID 1317301. S2CID 29330026. Ahmed CM, Ware DH, Lee SC, et al. (1992). " ... 264 (1): 113-22. doi:10.1016/S0378-1119(00)00594-1. PMID 11245985. Malacarne M, Gennaro E, Madia F, et al. (2001). "Benign ...
https://thesaucersthattimeforgot.blogspot.com/2019/06/ufos-contact-in-comics-from-1964.html Comics Kingdom Toonopedia entry NCS ... Distributed by King Features Syndicate, it had a run from November 1, 1943 to October 7, 1989. The last strip signed by Crane ... The first volume covers the daily strips from 1 November 1943 (the first strip) until 5 October 1945 (when Buz leaves the Navy ...
"Contactin-4 mediates axon-target specificity and functional development of the accessory optic system". Neuron. 86 (4): 985-999 ... 31 (1): 479-509. doi:10.1146/annurev.neuro.31.060407.125533. PMC 2655105. PMID 18558864. CS1 maint: discouraged parameter (link ...
Bakkaloglu B, O'Roak BJ, Louvi A et al.. Molecular cytogenetic analysis and resequencing of Contactin Associated Protein-Like 2 ... 2007;12(1):2-22. doi:10.1038/sj.mp.4001896. PMID 17033636. Sykes NH, Lamb JA. Autism: the quest for the genes. Expert Rev Mol ... 2003;40(1):4e-4. doi:10.1136/jmg.40.1.e4. PMID 12525552. Auranen M, Varilo T, Alen R, et al.. Evidence for allelic association ... 2006;87(1):75-83. doi:10.1016/j.ygeno.2005.09.008. PMID 16311013. Skaar DA, Shao Y, Haines JL, et al.. Analysis of the RELN ...
... neurogranin and contactin-2. The CBAS team is well established and internationally recognized, and has multiple international ... Andel R (1 December 2014). "Aging in the Czech republic". The Gerontologist. 54 (6): 893-900. doi:10.1093/geront/gnu047. PMID ...
CASPR2 and Contactin-2, within neurons, glia and the nerve-muscle junction in the pathogenesis of above-mentioned diseases. She ... Retrieved 1 July 2010. "Prizes awarded by the British Neuroscience Association , The British Neuroscience Association". www.bna ...
Since his performance material often involves themes of mortality and spirit contact-in addition to demonstrations of telepathy ... wgntv-morning-news-1 Houdini's Halloween[permanent dead link] from WGN-TV and Red Eye, October 28, 2005 His Magic Helps Kids ...
... beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on interactions with contactin and ... Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene. Voltage-gated sodium channels are ... 148 (1): 164-74. doi:10.1016/j.neuroscience.2007.05.038. PMID 17629415. S2CID 36136731. GeneReviews/NIH/NCBI/UW entry on ... Biochemically, they consist of a large alpha subunit and 1 or 2 smaller beta subunits, such as SCN1B. The alpha subunit alone ...
Contactin 1, also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene. The protein encoded by this gene ... "Entrez Gene: CNTN1 contactin 1". CS1 maint: discouraged parameter (link) Sakurai T, Lustig M, Nativ M, Hemperly JJ, ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ... Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on ...
In association with contactin, it may have a role in the signaling between axons and myelinating glial cells [PMID: 9118959, ... Contactin-associated protein 1 (also known as paranodin or caspr1) has a key role in the formation of the paranodal junctions ... Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4- ... Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein ...
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo- ... IPR036992. Contactin-1. IPR003961. FN3_dom. IPR036116. FN3_sf. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig ... IPR036992. Contactin-1. IPR003961. FN3_dom. IPR036116. FN3_sf. IPR007110. Ig-like_dom. IPR036179. Ig-like_dom_sf. IPR013783. Ig ... Cluster: Contactin-1. 140. Q12860-3. UPI000B541AE2. UPI000643459F. UPI0002C47707. UPI00054040F8. UPI0003F17F70. UPI000703EA1B. ...
View our 9 Contactin-1 products for your research including Contactin-1 Primary Antibodies, Proteins and Enzymes, cDNA Clones, ... Contactin-5 (NB-2), and Contactin-6 (NB-3) form the contactin subgroup of cell adhesion molecules within the immunoglobulin ... also known as Contactin in human, F3 in rodent, and F11 in chicken), Contactin-2 (TAX-1 in human, TAG1 in rat, and Axonin-1 in ... Contactin-1 and -2 are differentially expressed in a number of neuronal tissues during development and interact with several ...
Contactin-associated protein like 5-1Add BLAST. 1281. Amino acid modifications. Feature key. Position(s). DescriptionActions. ... sp,Q0V8T6,CTP5A_RAT Contactin-associated protein like 5-1 OS=Rattus norvegicus OX=10116 GN=Cntnap5a PE=2 SV=1 ... 1 - 24. Sequence analysisAdd BLAST. 24. ,p>This subsection of the PTM / Processing section describes the extent of a ... SSF56496 SSF56496, 1 hit. PROSITEi. View protein in PROSITE. PS50026 EGF_3, 2 hits. PS01285 FA58C_1, 1 hit. PS50022 FA58C_3 ...
Anti-contactin-1-associated neuropathy does not meet morphological criteria of demyelinating neuropathy and therefore, might ... Methods We used ELISA to detect autoantibodies against contactin-1. Specificity of the autoantibodies was confirmed by ... Results High reactivity to contactin-1 by ELISA was found in four patients with chronic inflammatory demyelinating ... Interpretation We conclude that anti-contactin-1-related neuropathy constitutes a presumably autoantibody-mediated form of ...
Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 ... Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 ...
Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse ... CNTN1 / gp135 / Contactin 1 Antibody (aa81‑130, FITC) LS‑C466250 Species: Human, Chimpanzee, Orangutan, Gibbon, Monkey, Rat, ... Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse ... Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse ...
Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). Validated ... CNTN1 / gp135 / Contactin 1 Antibody (aa81‑130, FITC) LS‑C466250 Species: Human, Chimpanzee, Orangutan, Gibbon, Monkey, Rat, ... Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). Validated ... Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). Validated ...
Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA - 10 µg - OriGene ... home , products , origene , myc-ddk-tagged orf clone of homo sapiens contactin 1 (cntn1), transcript variant 1 as transfection- ... Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA - RC214706 - 10 µg ... TrueORF Myc-DDK-tagged ORF clone of Homo sapiens contactin 1 (CNTN1), transcript variant 1 as transfection-ready DNA ...
Contactin-3 is a protein that in humans is encoded by the CNTN3 gene. GRCh38: Ensembl release 89: ENSG00000113805 - Ensembl, ... "Entrez Gene: CNTN3 contactin 3 (plasmacytoma associated)". Human CNTN3 genome location and CNTN3 gene details page in the UCSC ... 2001). "Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression ... 69 (1): 113-9. doi:10.1006/geno.2000.6310. PMID 11013081. Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the ...
Contactin is required for L1- and laminin-induced Fyn activation. A, Expression of contactin and Fyn and the level of Fyn ... Note that the contactin siRNAs reduce protein expression at all time points. B, Survival of OPCs transfected with contactin or ... Contactin expression in oligodendrocytes. A, Western blot for contactin expression in OPCs at the time of plating or after ... Contactin is required for integrin- and L1-mediated oligodendrocyte survival. A, Contactin expression in cultured OPCs 1-4 d ...
Contactin-1. Yeast two-hybrid. Rat. 1-432. Human. Fetal brain. cDNA library. 17074976. ... Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo- ... suppl 1 (2011): D356-D361. *Young-Cheul Shin, Soo-Yong Shin, Jung Nyeo Chun, Hyeon Sung Cho, Jin Muk Lim, Hong-Gee Kim, Insuk ... Genet.. May 2000;25(1):25-9. World Wide Web URL: http://www.geneontology.org/ ...
KDs: contactin 4-APP, 17 nM; contactin 4-APLP1, 28 nM; contactin 3-APP, 22 nM; contactin 3-APLP1, 35 nM; and contactin 5-APLP1 ... Our studies show that APP binds both contactin 3 and 4. APLP1 was found to bind contactins 3 and 4, and also contactin 5. These ... On contactin 4, the APP-binding site localizes to the FN-like domains, which could leave the Ig domains of contactin free to ... APP and APLP1 bind to specific contactin family members. (A) AP fusion proteins were tested for binding to contactin-Fc fusion ...
Browse our Contactin-2/TAG1 Lysate catalog backed by our Guarantee+. ... contactin 2 (axonal) lysate, contactin 2 (transiently expressed) lysate, contactin-2 lysate, DKFZp781D102 lysate, FLJ37193 ... Our Contactin-2/TAG1 Lysates can be used in a variety of model species. Use the list below to choose the Contactin-2/TAG1 ... We offer Contactin-2/TAG1 Lysates for use in common research applications: Western Blot. Each Contactin-2/TAG1 Lysate is fully ...
Contactin 1) ELISA Kit OSCAR DIAGNOSTIC SERVICES PVT. LTD.is an India based Company in Delhi. ... Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 (Contactin 1) ELISA Kit ... Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 ... Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 (Contactin 1) ELISA Kit Porcine CNTN1 ...
Recombinant Contactin 2 (Axonal) (CNTN2) Protein (His tag). Species: Human. Source: Escherichia coli (E. coli). Order product ... Contactin 2 (Axonal) (CNTN2) (AA 877-1040) protein (His tag) Protein CNTN2 Origin: Human Source: Escherichia coli (E. coli) ... Contactin 2 (Axonal) (CNTN2) (AA 802-1008) protein (T7 tag,His tag) Protein ... 1 877 302 8632. Fax:. +1 888 205 9894 (Toll-free). E-Mail:. [email protected] ...
Plagge, A; Sendtner-Voelderndorff, L; Sirim, P; Freigang, J; Rader, C; Sonderegger, P; Brümmendorf, T (2001). The contactin- ... FAR-2 is a novel neural member of the Ig superfamily, which is related to F11/F3/contactin and axonin-1/TAG-1. This protein is ... FAR-2 is a novel neural member of the Ig superfamily, which is related to F11/F3/contactin and axonin-1/TAG-1. This protein is ... The contactin-related protein FAR-2 defines purkinje cell clusters and labels subpopulations of climbing fibers in the ...
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus. ... Cntnap4 interacts with 174 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All ... 8 phenotypes from 1 allele in 1 genetic background 5 phenotype references ...
contactin-1. (redirected from F11). Also found in: Acronyms, Wikipedia. contactin-1. A 130-kD glycoprotein cell adhesion ... Contactin-1 is differentially expressed in various neuronal tissues during development and interacts with several ligands-Nr- ... Sources pointed out CDA had built libraries and gyms in street No 58 sector I8/1, sector G8/2, sector F11 and sector G11 at ...
Invitrogen Anti-Contactin 5 Polyclonal, Catalog # PA5-58814. Tested in Western Blot (WB), Immunofluorescence (IF), ... Cite Contactin 5 Polyclonal Antibody. The following product was used in this experiment: Contactin 5 Polyclonal Antibody from ... Immunofluorescent staining of Contactin 5 in human cell line U-2 OS shows positivity in cytoplasm. Samples were probed using a ... Immunohistochemical staining of Contactin 5 in human kidney tissue shows strong cytoplasmic positivity in tubular cells. ...
Unconjugated Contactin 1, Polyclonal, Invitrogen™ Primary Antibodies Ci to Cx ...
Contactin 6 / NB-3 (mouse aa160-172) Antibody (internal region), Peptide-affinity purified goat antibody validated in E ( ... Contactin-6, Neural recognition molecule NB-3, hNB-3, CNTN6. Format 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with ... Contactin 6 / NB-3 (mouse aa160-172) Antibody (internal region) is for research use only and not for use in diagnostic or ... home , Products , Primary Antibodies , Antibody Collections , Goat Antibodies , Contactin 6 / NB-3 (mouse aa160-172) Antibody ( ...
CNTN4: Contactin 4. *COL7A1: Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) ... 978-1-136-84407-2. .. *^ a b c Genome Decoration Page, NCBI. Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3). ... SFMBT1: Scm-like with four mbt domains 1. *SLC25A20: solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 ... TRAK1: trafficking kinesin-binding protein 1. *TRANK1: encoding protein Tetratricopeptide repeat and ankyrin repeat containing ...
CANCER CONTACT - In the same boat??????. I am in the boat. I am in a simular situation. Stage IV Andoeocarcinoma. We are at MD ... 1. What do I know (or think I know) about cancer (after 6 weeks study -offen 12-14 hours a day) - nearly nothing because I am ... 1. I am an early retired CPA and former equity partner (64) from Denmark and despite my education I should start from scratch ... 1. I have - as mentioned - during the last 6 weeks been reading books, articles on the internet, seen vidoes etc. (also about ...
2000 Antifreeze Proteins by Bill Nye for National Science Foundation.oga 1 min 3 s; 508 KB. ... 2ph1 pdb gallery nucleotide binding-protein-2 (MinD homolog).svg 1 101 × 745; 302 KB. ... 2L6X Active Site Visualization E.Vitureira.png 1 054 × 770; 275 KB. ... У гэтай катэгорыі ёсць наступныя 200 файлаў з агульнага ліку 1 125. ...
Contactin-1. Rituximab. Additional relevant MeSH terms:. Layout table for MeSH terms. ... Serum antibody titers of IgG4 (CNTN-1 and NF-155) and these IgG subclass [ Time Frame: Up to 52 weeks ]. Serum titers (CNTN-1 ... R-ODS is consist of a 24-item questionnaire about daily living task with 3 response options: (0) impossible to perform, (1) ... i) Patients with positive serum IgG4 autoantibody (CNTN-1 or NF-155) confirmed by the time of enrollment in the study ...
... myr-PTPα/contactin (myr-α/cont), or PTPα/contactin (α/cont) were probed for PTPα and contactin. (B) Whole cell lysates (WCL) ... myr-PTPα/contactin (myr-α/cont), or PTPα/contactin (α/cont) were probed for PTPα and contactin. (B) Whole cell lysates (WCL) ... Coclusters of contactin and PTPα could also be induced by 4D1 mAb specific for contactin ( Fig. 3C and Fig. D). Clusters of ... PTPα and Contactin Are Associated in Chick Brain. Contactin and PTPα immunoprecipitates from embryonic chick brain lysates were ...
... is an axonal cell adhesion molecule that belongs to the contactin family. This protein has the ability to promote neurite ... Contactin family proteins exist as membranebound proteins, but can also be released as soluble proteins by GPIspecific ... Rat hippocampal neurons grown on microplates pre-coated with human Contactin-4 ... Rat hippocampal neurons grown on microplates pre-coated with human Contactin-4 ...
2001). «Contactin associates with Na+ channels and increases their functional expression.». J. Neurosci. 21 (19): 7517-25. PMID ... 2001). «Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent.». Eur. J. ... Berglund EO, Ranscht B (1994). «Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome ... Berglund EO, Ranscht B (1994). «Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome ...
  • Contactin 1, also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene. (wikipedia.org)
  • Contactin 1 antibody LS-C386882 is an unconjugated rabbit polyclonal antibody to Contactin 1 (CNTN1 / gp135) from human, mouse and rat. (lsbio.com)
  • Contactin 1 antibody LS-C723253 is a PE-conjugated rabbit polyclonal antibody to human Contactin 1 (CNTN1 / gp135). (lsbio.com)
  • The contactin family comprises six members (CNTN1/F3, CNTN2/TAG1, CNTN3/BIG1, CNTN4/BIG2, CNTN5/NB2 and CNTN6/NB3) and are characterized by the presence of six Ig like domains, four fibronectin type III like repeats, and a glycosylphosphatidylinositol (GPI) anchoring domain. (neuromics.com)
  • CNTN1 (contactin 1), a protein involved in oligodendrocyte maturation (Hu et al. (wikipathways.org)
  • Three cell adhesion molecules, contactin-1 (CNTN1) and contactin-associated protein-1 (CASPR1) in the axons, and neurofascin155 (NF155) in the myelin are responsible for the adhesion and the formation of septate-like junctions (also known as transverse bands) (FIG. 1). (docme.ru)
  • 2017) demonstrated detachment of terminal myelin loops from the axolemma without classical macrophage-mediated demyelination antibodies in 1 patient with CNTN1 antibodies. (docme.ru)
  • Contactin-associated protein 1 (also known as paranodin or caspr1) has a key role in the formation of the paranodal junctions and is required for normal saltatory conduction [ PMID: 11395000 ]. (ebi.ac.uk)
  • Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions. (ebi.ac.uk)
  • Contactin-associated protein 1 (Caspr1) regulates the traffic and synaptic content of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors. (ebi.ac.uk)
  • Contactin 1 Polyclonal Antibody detects endogenous levels of Contactin 1 protein. (lsbio.com)
  • Contactin-3 is a protein that in humans is encoded by the CNTN3 gene. (wikipedia.org)
  • In vitro binding studies revealed direct interactions among multiple members of the APP and contactin protein families. (biologists.org)
  • The contactin-related protein FAR-2 defines purkinje cell clusters and labels subpopulations of climbing fibers in the developing cerebellum. (uzh.ch)
  • The protein encoded by this gene is a member of the immunoglobulin superfamily, and contactin family, which mediate cell surface interactions during nervous system development. (thermofisher.com)
  • Recombinant Human Contactin-4 or CNTN4 Protein. (neuromics.com)
  • Association of Leucine-Rich Glioma Inactivated Protein 1, Contactin-Associated Protein 2, and Contactin 2 Antibodies With Clinical Features and Patient-Reported Pain in Acquired Neuromyotonia. (ox.ac.uk)
  • Importance: Although acquired autoimmune neuromyotonia (NMT) is associated with voltage-gated potassium channel (VGKC)-complex antibodies, to date there has been no systematic study of autoantibodies to the specific antigens leucine-rich glioma inactivated protein 1 (LGI1), contactin-associated protein 2 (CASPR2), and contactin 2 together with the full clinical syndrome, particularly pain and autonomic and central nervous system involvement. (ox.ac.uk)
  • Antibodies to Kv1 potassium channel-complex proteins leucine-rich, glioma inactivated 1 protein and contactin-associated protein-2 in limbic encephalitis, Morvan's syndrome and acquired neuromyotonia. (ox.ac.uk)
  • and (iii) Tag-1/contactin-2 that associates with contactin-associated protein-2. (ox.ac.uk)
  • Antibodies to Kv1 subunits were found in three sera, to contactin-associated protein-2 in 19 sera, to leucine-rich, glioma inactivated 1 protein in 55 sera and to contactin-2 in five sera, four of which were also positive for the other antibodies. (ox.ac.uk)
  • The responses to immunomodulatory therapies, defined by changes in modified Rankin scores, were good except in the patients with tumours, who all had contactin-associated-2 protein antibodies. (ox.ac.uk)
  • furthermore, detection of contactin-associated protein-2 antibodies should help identify the risk of an underlying tumour and a poor prognosis in future patients. (ox.ac.uk)
  • Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. (semanticscholar.org)
  • Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. (nature.com)
  • In sciatic nerve, the expression of contactin, receptor protein tyrosine phosphatase β, and the Na + -channel β 1 subunit, paranodal caspr and nodal ankyrin G was unaltered in 2-month type 1 diabetic BB/Wor rats but significantly decreased after 8 months of diabetes. (diabetesjournals.org)
  • CNTN2 (Contactin 2) is a Protein Coding gene. (genecards.org)
  • An important gene associated with Autism 15 is CNTNAP2 (Contactin Associated Protein Like 2). (malacards.org)
  • Investigators identified an antibody in the serum of MS patients that targeted a brain protein - contactin-2/transiently expressed axonal glycoprotein (TAG-1) - that seems to trigger gray matter demyelination, and they think it could be a useful new model for targeted therapies for multiple sclerosis. (lww.com)
  • Tobias Derfuss, MD, and his colleagues at the Max Planck Institute of Neurobiology in Germany, identified an antibody in the serum of MS patients that targeted a brain protein - contactin-2/transiently expressed axonal glycoprotein (TAG-1). (lww.com)
  • Results from the European study suggest that "immune-mediated inflammation targeted at the protein contactin-2 on or near gray matter endothelial cells opens the blood-brain barrier or alters endothelial cells in the gray matter, permitting effectors of demyelination (such as antibodies to myelin proteins) to gain access to gray matter," Drs. Trapp and Rudick wrote in their editorial. (lww.com)
  • There are 5 Contactin 3 protein produced in house with high quality which are covering various species. (sinobiological.com)
  • Among these Contactin 3 proteins, there are 2 Human Contactin 3 protein, 1 Mouse Contactin 3 protein, 2 Rat Contactin 3 protein. (sinobiological.com)
  • All these Contactin 3 protein are expressed by different host cells. (sinobiological.com)
  • TAG-1/axonin-1 is a high-affinity ligand of neurocan, phosphacan/protein-tyrosine phosphatase-zeta/beta, and N-CAM. (semanticscholar.org)
  • An international group headed by medical scientist Professor Edgar Meinl of LMU Munich has now discovered a possible connection: The protein Contactin-2 is produced both in the myelin sheathing and by neurons in the gray matter - and is attacked by misdirected immune factors. (uni-muenchen.de)
  • In an animal model, autoresponsive T-cells responded to TAG-1, the animal protein analogous to human Contactin-2. (uni-muenchen.de)
  • Background: The solute carrier family 39 (zinc transporter) member 7 (SLC39A7, ZIP7) is an ER and Golgi membrane protein that regulates cellular zinc homeostasis by controlling release of zinc from these organelles to the cytoplasm (1,2). (cellsignal.com)
  • Protein-tyrosine phosphatase receptor type G (RPTPγ/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycophosphatidylinositol-anchored cell adhesion molecules involved in the wiring of the nervous system. (rcsb.org)
  • The Abs are directed against membrane receptors and ion channel-associated proteins that are expressed on the surface of neurons in the CNS, such as N -methyl D-aspartate receptors and leucine-rich, glioma inactivated 1 protein and contactin-associated protein like 2, that are associated with voltage-gated potassium channels. (springer.com)
  • Insomnia and Dysautonomia with Contactin-Associated Protein 2 and Leucine-Rich Glioma Inactivated Protein 1 Antibodies: A "Forme Fruste" of Morvan Syndrome? (annals.org)
  • Contactin4 (CNTN4), also known as BIG2 (Brainderived Immunoglobulin Superfamily molecule 2), is an axonal cell adhesion molecule that belongs to the contactin family, a subfamily of the Ig superfamily (1 3). (neuromics.com)
  • Disruption of Contactin 4 (CNTN4) results in developmental delay and other features of 3p deletion syndrome. (semanticscholar.org)
  • 2000). «Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression. (wikipedia.org)
  • This gene encodes a member of the contactin family of proteins, part of the immunoglobulin superfamily of cell adhesion molecules. (genecards.org)
  • Co-precipitation from these tissues and tandem mass spectrometry led to the identification of two associated proteins: contactin 4 and NgCAM. (biologists.org)
  • Functional assays revealed regulatory effects of both APP and contactin 4 on NgCAM-dependent growth of cultured retinal axons, demonstrating specific functional interactions among these proteins. (biologists.org)
  • These studies identify novel binding and functional interactions among proteins of the APP, contactin and L1CAM families, with general implications for mechanisms of APP action in neural development and disease. (biologists.org)
  • Contactin family proteins exist as membranebound proteins, but can also be released as soluble proteins by GPIspecific phospholipase D. Soluble Contactins are functionsl proteins that are able to promote neurite outgrowth. (neuromics.com)
  • Most of the initially described anti-neural autoantibodies are directed against intracellular proteins like Hu, Yo, Ri, Ta, GAD, and amphiphysin ( 1 ). (frontiersin.org)
  • These Contactin 3 proteins are produced with different tags, such as His Tag, Fc Tag. (sinobiological.com)
  • Sophisticated approaches have recently led to the identification of novel autoantigens associated with Multiple Sclerosis (MuS), e.g. neurofascin, contactin, CNPase, and other T-cell receptor membrane anchored proteins. (mcponline.org)
  • Proteomic analysis of the immunoreactive bands, involving MALDI and MS/MS techniques, revealed the presence of four proteins distinguishable by their mass: alpha fodrin, alpha actinin 1, creatine kinase, and CNPase. (mcponline.org)
  • Background: Bone morphogenetic proteins (BMPs) were first identified as molecules that can induce ectopic bone and cartilage formation (1,2). (cellsignal.com)
  • Contactin-2 triggers an immune response in which T-cells and antibodies turn against this molecule," reports Meinl. (uni-muenchen.de)
  • Contactin-1 and Neurofascin-155/-186 Are Not Targets of Auto-Antibodies in Multifocal Motor Neuropathy. (uni-muenchen.de)
  • We did not detect IgM anti-neurofascin-186 or anti-contactin-1 antibodies in this cohort. (uni-muenchen.de)
  • 2001). «Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent. (wikipedia.org)
  • Downregulationof pregnancy-specific beta-1-glycoprotein 9 (PSG9) in the LOPE group was confirmed by ELISA. (peerj.com)
  • Results High reactivity to contactin-1 by ELISA was found in four patients with chronic inflammatory demyelinating polyradiculoneuropathy and in none of the patients with Guillain-Barré syndrome, which was confirmed by cell binding assays in all four patients. (bmj.com)
  • In direct ELISAs and Western blots, approximately 15% cross-reactivity with recombinant mouse Coagulation Factor VII and less than 1% cross-reactivity with recombinant human Coagulation Factor XA is observed. (novusbio.com)
  • The European team said that the finding suggests that a contactin-2 specific T-cell response contributes to the gray matter pathology that occurs in MS. The investigators mined human brain tissue from MS patients and controls looking for antibody reactivity against select glycoproteins. (lww.com)
  • C ontactin-1 (also known as Contactin in human, F3 in rodent, and F11 in chicken), Contactin-2 (TAX-1 in human, TAG1 in rat, and Axonin-1 in chicken), Contactin-4 (BIG-1), Contactin-5 (NB-2), and Contactin-6 (NB-3) form the contactin subgroup of cell adhesion molecules within the immunoglobulin superfamily. (rndsystems.com)
  • 2002). «Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members. (wikipedia.org)
  • We first demonstrate that the Ig superfamily molecule contactin is associated in oligodendrocytes with integrins, extracellular matrix receptors that regulate target-dependent survival by amplification of growth factor signaling. (jneurosci.org)
  • FAR-2 is a novel neural member of the Ig superfamily, which is related to F11/F3/contactin and axonin-1/TAG-1. (uzh.ch)
  • The most highly enriched transcript in Purkinje fibers encoded Contactin-2 ( Cntn2 ), a cell adhesion molecule critical for neuronal patterning and ion channel clustering. (scialert.net)
  • Die Arbeit basiert auf den aktuellen Leitlinien und einer selektiven Literaturrecherche in PubMed nach gro en Kohortenstudien sowie randomisierten kontrollierten Studien von 2000 2017 mit Fokus auf den nichtheredit ren Formen der Polyneuropathie. (aerzteblatt.de)
  • 2017 Jul 13;10(1):333. (gene-tools.com)
  • We demonstrate that PTPα, an RPTP that dephosphorylates and activates src family kinases, forms a novel membrane-spanning complex with the neuronal GPI-anchored receptor contactin. (rupress.org)
  • Multiple neural autoantibodies are associated with autonomic disorders (ganglionic nicotinic acetylcholine receptor antibody, ANNA-1, P/Q and N-type VGCCs, NMDA, CASPR2, DPPX). (medscape.com)
  • Contactin is a noncanonical Notch receptor ligand that mediates oligodendrocyte differentiation. (jci.org)
  • In contrast, the presence of L1-Fc, the extracellular portion of a contactin ligand expressed on axons, enhanced survival and additionally promoted myelination in cocultures of neurons and oligodendrocytes. (jneurosci.org)
  • Homology modeling using axonin-1 as a template reveals that the four aminoterminal Ig domains of FAR-2 form a compact U-shaped structure, which is likely to contain functionally important ligand-binding sites. (uzh.ch)
  • This amplification is inhibited by small interfering RNA-mediated knockdown of contactin in oligodendrocytes. (jneurosci.org)
  • Knockdown of contactin-1 expression suppresses invasion and metastasis of lung adenocarcinoma. (nature.com)
  • The β 1 -subunit of the Na + -channel complex and ankyrin G interact with the L1-family cell adhesion molecule (CAM) neurofascin, Nr-CAM, N-cadherin, and L1 at the node ( 14 , 19 , 20 ), thereby mediating contacts with Schwann cell microvilli ( 18 ). (diabetesjournals.org)
  • Loss of laminin alpha 1 results in multiple structural defects and divergent effects on adhesion during vertebrate optic cup morphogenesis. (semanticscholar.org)
  • Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. (gu.se)
  • The following product was used in this experiment: Contactin 5 Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-58814, RRID AB_2640053. (thermofisher.com)
  • We describe the clinical phenotype and histopathological changes of paranodal architecture of patients with autoantibodies against contactin-1, identified from a cohort with chronic inflammatory demyelinating polyradiculoneuropathy (n=53) and Guillain-Barré syndrome (n=21). (bmj.com)
  • Methods We used ELISA to detect autoantibodies against contactin-1. (bmj.com)
  • Specificity of the autoantibodies was confirmed by immunoblot assay, binding to contactin-1-transfected human embryonic kidney cells, binding to paranodes of murine teased fibres and preabsorption experiments. (bmj.com)
  • [ 48 ] Profound insomnia is a characteristic feature of Morvan's syndrome, associated with CASPR2 or LGI-1 autoantibodies. (medscape.com)
  • They discovered that contactin-2/TAG-1 was recognized by both autoantibodies and T-helper cells. (lww.com)
  • Additionally they shared two unusual features, a poor response to intravenous immunoglobulins (IVIg) and the finding that the autoantibodies were predominantly of the IgG4 isotype (Table 1). (docme.ru)
  • Methods In the present study, we screened a large cohort of patients (n=140) with inflammatory neuropathies for IgM autoantibodies against neurofascin-155, neurofascin-186 or contactin-1. (uni-muenchen.de)
  • Contactin-1 and -2 are differentially expressed in a number of neuronal tissues during development and interact with several ligands including Nr-CAM, L1, NCAM, neurocan, phosphacan, and tenascin. (rndsystems.com)
  • We offer Contactin-2/TAG1 Lysates for use in common research applications: Western Blot. (novusbio.com)
  • 2001). «Contactin associates with Na+ channels and increases their functional expression. (wikipedia.org)
  • Synthesized peptide derived from human Contactin 1. (lsbio.com)
  • show that Contactin is abundantly expressed on demyelinated axons in human chronic MS lesions and that Notch1 is activated in oligodendrocyte precursor cells (see the related article beginning on page 169). (jci.org)
  • Our Contactin-2/TAG1 Lysates can be used in a variety of model species. (novusbio.com)
  • Contactins mediate cell surface interactions during nervous system development. (uniprot.org)
  • Interactions between contactin, ankyrin G , and the β-subunits are critical to Na + -channel α-subunit enrichment and localization at the node ( 16 - 18 ) ( Fig. 1 ). (diabetesjournals.org)
  • In association with contactin, it may have a role in the signaling between axons and myelinating glial cells [ PMID: 9118959 , PMID: 9292722 , PMID: 9396755 , PMID: 9786343 ]. (ebi.ac.uk)
  • Nodes of Ranvier are known as the gaps (about 1 micrometer in diameter) formed between myelin sheath cells along axons or nerve fibers. (bionity.com)
  • The transmembrane and catalytic nature of PTPα indicate that it likely forms the transducing element of the complex, and we postulate that the role of contactin is to assemble a phosphorylation-competent system at the cell surface, conferring a dynamic signal transduction capability to the recognition element. (rupress.org)
  • Main Outcomes and Measures: Clinical data and scores on the modified Rankin Scale (mRS), which measures disability on a range of 0 to 6, with 0 indicating normal and 6 indicating death, before and after treatments were combined with CASPR2, LGI1, and contactin 2 antibody status. (ox.ac.uk)
  • Each Contactin-2/TAG1 Lysate is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Choose from our Contactin-2/TAG1 Lysates. (novusbio.com)
  • To explore the molecular abnormalities underlying the degeneration of the node of Ranvier, a characteristic aberration of type 1 diabetic neuropathy, we examined in type 1 BB/Wor and type 2 BBZDR/Wor rats changes in expression of key molecules that make up the nodal and paranodal apparatus of peripheral nerve. (diabetesjournals.org)
  • Expression of a contactin family member within the CCS may provide a mechanistic basis for patterning of the conduction system network and the organization of ion channels within Purkinje cells. (scialert.net)
  • Topographic restriction of TAG-1 expression in the developing retinotectal pathway and target dependent reexpression during axon regeneration. (semanticscholar.org)
  • This mode of membrane attachment precludes direct transfer of signals into the cell, but allows high mobility in the plane of the membrane, and as such ideally suits contactin for responding to macromolecular stimuli presented to the cell ( Vaughan 1996 ). (rupress.org)
  • They consist of the pore-forming α-subunit and two auxiliary subunits, β 1 and β 2 , which act as cell adhesive anchors ( 15 ). (diabetesjournals.org)
  • Murine Tsc1/2 have been shown to negatively regulate the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway in most tissues, and this pathway has been shown to be essential for proper oligodendrocytes/Schwann cell differentiation and myelination. (frontiersin.org)
  • PTPα and contactin associate in a lateral (cis) complex mediated through the extracellular region of PTPα. (rupress.org)
  • Molecular and Cellular Neuroscience, 18(1):91-107. (uzh.ch)
  • These data describe for the first time the progressive molecular aberrations underlying nodal and paranodal degenerative changes in type 1 diabetic neuropathy and demonstrate that they are preventable by insulinomimetic C-peptide. (diabetesjournals.org)
  • Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif. (wikipathways.org)
  • In the course of their investigations, they identified Contactin-2 as a new autoantigen - a molecular structure that belongs to the body but which provokes an immune response. (uni-muenchen.de)