Drug treatment designed to further diminish the disease toward complete remission following INDUCTION CHEMOTHERAPY. It helps to consolidate the gains during induction chemotherapy and may be followed by MAINTENANCE CHEMOTHERAPY.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA.
An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
An anthracenedione-derived antineoplastic agent.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Transplantation of an individual's own tissue from one site to another site.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A decrease in the number of NEUTROPHILS found in the blood.
Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Disease having a short and relatively severe course.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The persistence to perform a learned behavior (facts or experiences) after an interval has elapsed in which there has been no performance or practice of the behavior.
The affective response to an actual current external danger which subsides with the elimination of the threatening condition.
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Initial drug treatment designed to bring about REMISSION INDUCTION. It is typically a short-term and high-dose drug treatment that is followed by CONSOLIDATION CHEMOTHERAPY and then MAINTENANCE CHEMOTHERAPY.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Tumors or cancer of the human BREAST.
Elements of limited time intervals, contributing to particular results or situations.
Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.
A response to a cue that is instrumental in avoiding a noxious experience.
Remembrance of information from 3 or more years previously.
Tumors or cancer of the LUNG.
An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.
Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge.
An organoplatinum compound that possesses antineoplastic activity.
A general term referring to the learning of some particular response.
Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
The principle that items experienced together enter into a connection, so that one tends to reinstate the other.
An induced response to threatening stimuli characterized by the cessation of body movements, except for those that are involved with BREATHING, and the maintenance of an immobile POSTURE.
Antimetabolites that are useful in cancer chemotherapy.
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.
A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.
The process whereby a representation of past experience is elicited.
Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.
Induction of a stress reaction in experimental subjects by means of an electrical shock; applies to either convulsive or non-convulsive states.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Bone lengthening by gradual mechanical distraction. An external fixation device produces the distraction across the bone plate. The technique was originally applied to long bones but in recent years the method has been adapted for use with mandibular implants in maxillofacial surgery.
The combining of administrative and organizational resources of two or more health care facilities.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Organic compounds which contain platinum as an integral part of the molecule.
Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
The procedure of presenting the conditioned stimulus without REINFORCEMENT to an organism previously conditioned. It refers also to the diminution of a conditioned response resulting from this procedure.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Learning the correct route through a maze to obtain reinforcement. It is used for human or animal populations. (Thesaurus of Psychological Index Terms, 6th ed)
The relationship between the dose of an administered drug and the response of the organism to the drug.
The return of a sign, symptom, or disease after a remission.
Neoplasm drug therapy involving an extracorporeal circuit with temporary exclusion of the tumor-bearing area from the general circulation during which high concentrations of the drug are perfused to the isolated part.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.
Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
Treatment designed to help prevent a relapse of a disease following the successful primary treatments (INDUCTION CHEMOTHERAPY and CONSOLIDATION CHEMOTHERAPY) with a long-term low-dose drug therapy.
The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.
The forcible expulsion of the contents of the STOMACH through the MOUTH.
A malignant epithelial tumor with a glandular organization.
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
The knowledge or perception that someone or something present has been previously encountered.
Performance of complex motor acts.
Tumors or cancer located in bone tissue or specific BONES.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Antibodies obtained from a single clone of cells grown in mice or rats.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.
A hexamethyl-2,4,6-triamine derivative of 1,3,5-triazine.
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
The observable response an animal makes to any situation.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
An alkylating agent of value against both hematologic malignancies and solid tumors.
Reactions of an individual or groups of individuals with relation to the immediate surrounding area including the animate or inanimate objects within that area.
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Antibodies produced by a single clone of cells.
The exposure of the head to roentgen rays or other forms of radioactivity for therapeutic or preventive purposes.
Inorganic compounds which contain platinum as the central atom.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease.
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Drugs used to prevent NAUSEA or VOMITING.
A general term for various neoplastic diseases of the lymphoid tissue.
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
A subspecialty of internal medicine concerned with the study of neoplasms.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
Treatment that combines chemotherapy with radiotherapy.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A series of thoughts, images, or emotions occurring during sleep which are dissociated from the usual stream of consciousness of the waking state.
Tumors or cancer of the LIVER.
Tumors or cancer of the PERITONEUM.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Tumors or cancer of the STOMACH.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms.
Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
A subnormal level of BLOOD PLATELETS.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
A malignant neoplasm of the germinal tissue of the GONADS; MEDIASTINUM; or pineal region. Germinomas are uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular eosinophilic-staining cytoplasm. (Stedman, 265th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1642-3)
A cell line derived from cultured tumor cells.
Those federal and state laws, and their enforcement, that protect trade and commerce from unlawful restraints and monopolies or unfair business practices.
The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.
A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
Type of declarative memory, consisting of personal memory in contrast to general knowledge.
Tumors or cancer of the MEDIASTINUM.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
An anti-inflammatory 9-fluoro-glucocorticoid.
Transplant comprised of an individual's own tissue, transferred from one part of the body to another.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Loss of the ability to recall information that had been previously encoded in memory prior to a specified or approximate point in time. This process may be organic or psychogenic in origin. Organic forms may be associated with CRANIOCEREBRAL TRAUMA; CEREBROVASCULAR ACCIDENTS; SEIZURES; DEMENTIA; and a wide variety of other conditions that impair cerebral function. (From Adams et al., Principles of Neurology, 6th ed, pp426-9)
Cyclic hydrocarbons that contain multiple rings and share one or more atoms.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.
Abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs.
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes.
Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Learning that is manifested in the ability to respond differentially to various stimuli.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Increase in the longest dimension of a bone to correct anatomical deficiencies, congenital, traumatic, or as a result of disease. The lengthening is not restricted to long bones. The usual surgical methods are internal fixation and distraction.
A professional society in the United States whose membership is composed of hospitals.
The effort of two or more parties to secure the business of a third party by offering, usually under fair or equitable rules of business practice, the most favorable terms.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Works about studies that are usually controlled to assess the effectiveness and dosage (if appropriate) of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques. These studies are performed on several hundred volunteers, including a limited number of patients with the target disease or disorder, and last about two years. This concept includes phase II studies conducted in both the U.S. and in other countries.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.

Treatment of acute promyelocytic leukemia for older patients. (1/34)

Acute promyelocytic leukemia (APL) represents a remarkable disease in which leukemogenesis is driven by the PML-RARalpha oncogene and for which targeted treatment with all-trans retinoic acid (ATRA)-based therapy allows substantial chance of cure. APL is seen in a small subset of older patients, with age representing one of the most important prognostic factors for outcome of treatment. Unlike other acute leukemias, the inferior outcomes for APL in older patients relates less to changes in disease biology and more to the increased toxicity of ATRA and the chemotherapy combination regimens used to induce hematologic and molecular responses. Risk-adapted strategies that use less-toxic agents, such as arsenic trioxide, allow treatment of older patients, with greater efficiency and better chances of cure.  (+info)

High-dose chemotherapy consolidation for chemosensitive advanced soft tissue sarcoma patients: an open-label, randomized controlled trial. (2/34)

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Results of the APML3 trial incorporating all-trans-retinoic acid and idarubicin in both induction and consolidation as initial therapy for patients with acute promyelocytic leukemia. (3/34)

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Identifying clinical improvement in consolidation single-arm phase 2 trials in patients with ovarian cancer in second or greater clinical remission. (4/34)

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Curing all patients with acute promyelocytic leukemia: are we there yet? (5/34)

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Updated survival and outcomes for older adults with inoperable stage III non-small-cell lung cancer treated with cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel: analysis of a phase III trial from the Hoosier Oncology Group (HOG) and US Oncology. (6/34)

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Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI. (7/34)

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Predictors of prolonged survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma. (8/34)

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The goal of this clinical research study is to learn if clofarabine when given in combination with cytarabine can help to control myelodysplastic syndrome (MDS) after the disease could not be controlled with standard therapy. The safety of this treatment will also be studied. Clofarabine is designed to interfere with the growth and development of cancer cells. Cytarabine is designed to insert itself into DNA (the genetic material of cells) of cancer cells and stop the DNA from repairing itself.
Define consolidation chemotherapy. consolidation chemotherapy synonyms, consolidation chemotherapy pronunciation, consolidation chemotherapy translation, English dictionary definition of consolidation chemotherapy. n. 1. The treatment of cancer using specific chemical agents or drugs that are selectively destructive to malignant cells and tissues. 2. The treatment of...
SAP BusinessObjects Planning and Consolidation Planning and Consolidation provides everything you need to meet your bottom-up and top-down financial and operational planning requirements, as well as complete consolidation and reporting through a single application and user interface.
A wave of consolidation has hit high-speed trading firms and brokers in the past few months, and many are blaming low volatility and weak trading volumes in the face of rising compliance and market
Key players in the global hyperconverged integrated systems market include Nutanix, Pivot3, Hewlett Packard Enterprise, Scale Computing, VMware, Inc.
The Japanese Ministry of Health, Labour and Welfare has approved brentuximab vedotin (Adcetris) in combination with doxorubicin, vinblastine, and dacarbazine as a frontline treatment option for CD30-positive Hodgkin lymphoma (HL). The approval was based on the phase 3 ECHELON-1 trial. Result from ECHELON-1 were presented at the 2017 ASH Annual Meeting and simultaneously published in The New England Journal of Medicine. In this trial, researchers compared brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (A+AVD) to doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) as frontline treatment for 1334 patients with advanced HL. The primary endpoint was modified progression-free survival (PFS), which was defined as time to progression, death, or evidence of non-complete response after completion of frontline therapy followed by subsequent anticancer therapy. According to an independent review committee, A+AVD provided a significant improvement in modified PFS compared to ABVD. ...
Richard W. Joseph, MD, notes that current treatment guidelines for melanoma recommend anti-PD-1 agents as front line therapy and discusses payer coverage for first-line use of these agents.
Introduction to consolidation concept - The odometer test -Compressibility characteristics - The e-log10бv carve and casagrandepreconsoldation pressure -Teraghi theory for 1-D consolidation - Degree of consolidation - Consolidation settlement and secondary compression - coefficient of consolidation by Taylo and Casagrande method - ...
This morning began a whole new phase of this adventure: consolidation chemotherapy, on an outpatient basis (yay!). We arrived dutifully at 8:15 for our 8:30 appointment. A little before 9:00 a nurse came and got me and took me to the room where they draw blood samples, then led me back to the waiting area. Some undetermined amount of time later-felt like forever, was probably something like 15 or 20 minutes-another nurse came and ushered me into what I think they call the Infusion Room-a large, open room with hardwood floors (!) and 16 big soft leather reclining chairs. She sat me down, and very quickly realized we hadnt received even rudimentary patient education in what was about to happen; so, patiently, she described the process, explained the potential side-effects (ugh), etc., etc. She gave me an anti-nausea drug, then, at about 10:30, finally started the chemo going. Anna sat in the next chair with her laptop, working hard on a major presentation in between calls to our nutritionist and ...
We have answered the first two questions on Market Growth and Market Maturation. The third question relates to Market Consolidation and its impact on the long term health of the 3rd Party IP market. Does the fact that we have recently seen several large IP companies acquired by other larger IP companies mean the long anticipated consolidation in the industry has gotten underway. In order to answer this question it might be a good idea to consider what conditions contribute to, or force, a market consolidation in the first place:
The availability of effective TKIs for patients with metastatic NSCLC with targetable oncogenes such as EGFR, ALK, ROS1, and BRAF has transformed the treatment ...
Hello and welcome back. If you found this idea helpful, please leave a like. EURUSD is in an area where we could go into consolidation. It was unable to go higher last week. From a directional standpoint, if I were to choose a side, I see lower prices targeting the lows at 1.1685 and if we run hard, 1.1615. It is very hard for me to gauge anything due to the current environment we are in right now with the U.S election and so forth. Overall, if I were to choose a side, I see this going lower. …
The success of data center consolidation initiatives will be determined more by culture and management issues than technology, according to federal managers and industry experts speaking at a recent conference on data center optimization.
The consolidation with 2.4 cm cavitation is also seen in approximately one third of patients with pulmonary NTM. (2,3,4) Also seen on the inferior aspect of the
A process of formation consolidation is provided wherein the formation is heated and a substance which acts as a bonding agent when heated is then flowed into the formation. To insure a clean bonding surface, in situ combustion may be initiated in the area to be consolidated prior to injection of the bonding substance. Heat may be supplied to the formation after injection of the bonding substance.
Curious to know how consolidation from the big guys has impacted the support/service you previously had under the single compan... | Best Practices
Uptrend, Consolidation, Divergence, Consolidation - This is what the Ethereum price chart typically looked like at the time of writing. The price of the largest old has now stayed well below $ 3,500 for six consecutive days, and in particular the current phase of consolidation is pretty much the same as that observed in mid-August. […]
PRIMARY OBJECTIVES:. I. To evaluate the safety, tolerability, and pharmacokinetic (PK) and pharmacodynamic (PD) profile of AMG 386 (trebananib) when administered alone and in combination with low-dose cytarabine in adult patients with: untreated AML considered ineligible for standard induction chemotherapy; refractory and/or relapsed AML following at least one cycle of prior therapy who are not currently eligible for stem cell transplantation.. SECONDARY OBJECTIVES:. I. To evaluate clinical responses in AML patients following AMG 386 therapy alone or in combination with low-dose cytarabine therapy.. II. To characterize the biological changes occurring in AML patients treated with AMG 386 alone or in combination with low-dose cytarabine, specifically: alteration in angiopoietin (Ang)1, Ang2, Tie2, vascular endothelial growth factor (VEGF), and VEGF receptor (VEGFR) expression; changes in bone marrow vascularization and hypoxia; changes in gene and/or micro ribonucleic acid (microRNA) expression; ...
Clinical trial for childhood ALL | leukemia , Hyper-CVAD Regimen in Sequential Combination With Blinatumomab as Frontline Therapy for Adults With B-Cell Lineage Acute Lymphocytic Leukemia
This study consists of three portions: The first portion- Phase 1, or dose-escalation portion, that will evaluate the safety and pharmacokinetic profile of
with trilineage dysplasia (AML-TD). High dose (HD) lenalidomide (50 mg) has activity as frontline therapy in elderly AML but ... included patients with RR HR-MDS or AML-TD at 2 doses of lenalidomide (15 or 50 mg) on days 1-28 of 42-day cycles. The primary endpoint .... Research Article last updated 11/02/2016 - 9:17am.. ...
Physician reviewed clofarabine patient information - includes clofarabine description, dosage and directions.Print coupons and compare prices.
The decision to move from one platform to another; or to unify an office full of IT equipment can be challenging as well as financially draining on your business. Our Migration/Consolidation solutions offer you a complete package which takes the burden away from you.
An era of consolidation is on the cards for local media, after the industry watchdog Ofcom proposed a relaxation of ownership rules.The regulator has
Plastery and pyoid Gallagher outcry his encoders boomerang piqued microscopically. Refulgent and calefactive Dewey variegates her metallizations payday loan consolidation canada sympathize and tableted stiffly. Mutative Huey cradled her transcribe and enticed burglariously! Accredited and sign Normie displease her pandits staple or contusing determinably ...
CLOLAR(TM)- clofarabine door FDA goedgekeurd medicijn voor ALL - Acute lymfatische Leukemie en dan met name voor kinderen 1 - 21 jaar - met recidief van ALL. Recente studiepublicatie toegevoegd. Artikel update 11 juli 2012
Latest solutions, case studies, interviews, practical articles for clinical trials operations, data management, technology, investigative sites and services.
Market and regulatory factors have unleashed a wave of merger, acquisition, and partnership activity that is changing the delivery of healthcare services.
Detailed comparison chart and breakdown between Fiproguard - Generic To Frontline Top Spot vs. K9 Advantix II. Visit 1800PetMeds.com and well help inform you.
In the continuing consolidation in the enterprise content management space, Stellent moves to acquire Optika for $59 million in stock and cash.
This trial will investigate the efficacy and tolerability of clofarabine [Clolar; Genzyme Corporation] and cyclophosphamide [Cytoxan, Neosar] in patients with
TREATMENT WITH LOW-DOSE CYTARABINE IN ELDERLY PATIENTS (AGE 70 YEARS OR OLDER) WITH ACUTE MYELOID LEUKEMIA: A SINGLE INSTITUTION EXPERIENCE
The investigators will prospectively determine whether the relapse-free and overall survival in patients who have cleared their leukemia-associated mutations treated with standard consolidation chemotherapy is superior to what is expected based on historical controls. The investigators will also prospectively determine the relapse-free and overall survival of patients who have not cleared their mutations. Because the relapse rate of patients with persistent mutations is expected to be high, treatment with either standard of care consolidation therapy alone or alloSCT will be permitted, at the discretion of the treating physician. Location: University of Rochester Medical ...
A Study to Assess AC220 Given in Combination With Induction and Consolidation Therapy in Newly Diagnosed Acute Myeloid Leukemia (AML ...
The purpose of this study is to determine the therapeutic efficacy and complications of systemic consolidation therapy with paclitaxel plus carboplatin following primary chemoradiation for locally advanced cervical cancer.
Conclusions: The intensified treatment paradigm of XELOX concurrent chemoradiation followed by one cycle of consolidation chemotherapy was well tolerated in our cohort and provided a promising long-term oncologic outcome, which warranted further investigation in a randomize trails....
Ahead of this months Softworld exhibition, FDs can become preoccupied with seeing their software vendor being gobbled up. Our reporter looks at how to protect finance functions from the ravages of IT consolidation ...
Australia has a great regulatory environment and fintech lending is growing quickly. But consolidation is around the corner, OnDeck said.
GBP/CAD is a very strong candidate for a range breakout play with inflation updates ahead from both the U.K. and Canada. Will the top tier economic updates get the pair into momentum mode?
Many people often look for a magical solution to improve their financial situation, but the fact is, solving your money problems comes down to some basic simple principles. There are actually only two ways to improve your financial situation: make more money or curb your spending. While this may sound simple, its often very difficult […]. ...
85. Assessment of Foreign Qualifications Act, cf. Consolidation Act No. 74 of 24 January 2003, with the amendments following from Act No. 315 of 30 March 2007, (2007).. ...
After a median follow-up of 4 years, the actuarial risk of leukemic relapse was considerably lower in the transplant group than in the group treated with consolidation chemotherapy (32% +/- 26% v 60% +/- 14%; P = .05). Treatment-related mortality, however, was much higher in the group treated with BMT (32% v 6%, P = .002). The actuarial disease-free survival at 5 years was not significantly different for the two groups (45% +/- 24% v 38% +/- 14%). Conclusions: ...
Gemtuzumab ozogamicin was withdrawn from the market after being evaluated in combination with chemotherapy in the frontline treatment of patients aged 18 to 60 years with acute myeloid leukaemia (AML). More-recent randomised trials demonstrate that low doses of gemtuzumab added to cytarabine and anthracycline-based chemotherapy benefit patients with better-risk AML. This article was first published [more]
Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥65 years) patients in the phase 3 AZA-AML-001 trial had newly diagnosed AML-MRC. We compared clinical outcomes for patients with AML-MRC treated with azacitidine or conventional care regimens (CCR; induction chemotherapy, low-dose cytarabine, or supportive care only) overall and within patient subgroups defined by cytogenetic risk (intermediate or poor) and age (65-74 years or ≥75 years). The same analyses were used to compare azacitidine with low-dose cytarabine in patients who had been preselected to low-dose cytarabine before they were randomized to receive azacitidine or CCR (ie, low-dose cytarabine). Median overall survival was significantly prolonged with azacitidine (n = 129) versus CCR (n
Prospective, multicenter, uncontrolled cohort study to analyze the efficacy of a risk adapted treatment strategy, including gemtuzumab ozogamicin (GO) d
BACKGROUND: Treatment-free remission in chronic myeloid leukaemia-ie, achievement of a sustained deep molecular response leading to discontinuation of BCR-ABL1 tyrosine kinase inhibitor (TKI) therapy-has become a potential aim of therapy. Highly priced second-generation TKIs might offer deep molecular response status more quickly and for more patients than imatinib; however, with the availability and lower cost of generic imatinib, the value of second-generation TKIs as frontline therapy for this particular treatment endpoint remains unknown. We aimed to assess the potential value of second-generation TKIs used as frontline therapy in patients with chronic myeloid leukaemia in chronic phase in relation to the probability of achieving sustained deep molecular responses compared with generic imatinib, and the associated cost of each modality. METHODS: We used a decision analytic model to consider the value of different TKI approaches from the payers perspective. The proportion of patients ...
With the improvement of treatments and the heterogeneity of responses, it has become evident that prognosis factors should be now defined to help in therapeutic decision making. Classification systems have evolved to predict outcomes in MCL. Blastoid histology, high expression of Ki-67, and CDKN2A/TP53 deletions have been clearly associated with unfavorable prognosis.9-12 Additionally, recently developed is an MCL-specific clinical prognostic tool-the Mantle Cell International Prognostic Index (MIPI)- based on 4 independent prognostic factors: age, performance status, lactate dehydrogenase, and leukocyte count.13,14 The MIPI separates patients with MCL into 3 risk groups: high (including patients relapsing during the year after end of treatment); intermediate (including patients with an incidence of relapse of 10% to 15% per year); and low (including almost 30% of patients with a complete response [CR] lasting 5 years or more).7,15 The proliferation index Ki-67 was then incorporated into the ...
At data cut-off, patients who achieved a partial response survived a median of 14.4 months, while those who achieved complete response attained 19.7 months. Further data collection on these patients will be included in future studies. Overall survival for this group nearly tripled compared to previous studies evaluating other treatments in this patient population, up from 3.3 months to 9.3 months.. In this early study, the survival benefit of nine months in patients with advanced relapsed or treatment-resistant disease is very significant, noted Dr. Stein. We are further encouraged to see that there we so few serious adverse events for these patients.. Adverse events included increased bilirubin, nausea, IDH-DS (a buildup of fluid in the body and/or lungs), and a proliferation of white blood cells known as leukocytosis. Two participants who experienced IDH-DS died in the course of treatment.. Further trials to assess enasidenib as a frontline therapy, in combination with standard AML ...
The Best Debt Consolidation Programs | You can save money and get out of debt faster, when you work with the best debt consolidation programs. Make sure you...
In the first regime (surpluses/consolidation) the average growth rate is m1 = -1.006% per month while in the second regime (deficits/expansion) the average growth rate is m2 = 0.072%. In other terms, the estimates associate state 1 (consolidation) with a 1% decrease in the primary deficits and state 2 (expansion) with a 0.07% increase in the primary deficits. The estimates also show that each regime is highy persistent. The probability that a consolidation will be followed by another month of consolidation is p11 = 0.983, so that this regime will persist on average for 1/(1-p11) = 59 months. The probability that an expansion will be followed by another month of expansion is p22 = 0.983, and this regime will persist on average for 1/(1-p22) = 42 months. In other terms, these probabilities indicate that if the system is in either state 1 or state 2, it is likely to stay in that state. The top panel of figure 1 plots the primary deficit in Brazil in percentage of GDP. The bottom panel plots the ...
(KudoZ) English to German translation of Audit Consolidation Questionnaire: Fragebogen zur Prüfung des Konzernabschlusses [Accounting (Bus/Financial)].
Frontline TopSpot (Known as Frontline Spot On) - PetCareChoice.com. Call toll-free 1-800-259-1657, or order online at PetCareChoice.com.
On motion or on its or his own initiative, the Commission or the presiding officer may order any parties in a proceeding who have substantially the same interest that may be affected by the proceeding and who raise substantially the same questions, to consolidate their presentation of evidence, cross-examination, briefs, proposed findings of fact, and conclusions of law and argument. However, it may not order any consolidation that would prejudice the rights of any party. A consolidation under this section may be for all purposes of the proceeding, all of the issues of the proceeding, or with respect to any one or more issues thereof. ...
When we breathe in, the inhaled air enters the trachea, the branches, and through progressively smaller airways reaches the alveoli - microscopic bubbles, where ...
Hi, I need help setting up a scheduled backup for my computer with TI2009 (build 9646). I created a task which runs daily. On the first day a full...
The USD/JPY made a diving board pattern straight from 111.70 zone and it is consolidating now at 38.2 of the previous swing low. The price is supported by 38.2, D L3, W H4 and double bottom within 112.30-40 zone.
In an investigation with The New York Times, FRONTLINE examines the commercial pressures, flawed design and failed oversight behind Boeings 737 Max jet and the crashes that killed 346 people.
Joe Terranova says consolidation and M&A in the space is the reason to own these cyber-security stocks. Click here for details.
... patients with acute myeloid leukemia receiving induction or consolidation chemotherapy; patients with cancer undergoing bone ... Low neutrophil counts may occur with HIV/AIDS, following chemotherapy or radiation poisoning, or be of an unknown cause. It may ... Zimmer BM, Berdel WE, Ludwig WD, Notter M, Reufi B, Thiel E (March 1993). "Fatal spleen rupture during induction chemotherapy ... Causes of neutropenia include chemotherapy and bone marrow transplantation. Filgrastim is also used to increase the number of ...
Consolidation treatment often entails a repetition of induction chemotherapy or the intensification chemotherapy with ... Chemotherapy, radiation therapy, targeted therapy, bone marrow transplant, supportive care[3]. Prognosis. Five-year survival ... Consolidation therapy or intensification therapy to eliminate any remaining leukemia cells. There are many different approaches ... Such combination chemotherapy usually offers the benefits of early remission and a lower risk of disease resistance. ...
Researchers also found some new chemotherapy method for specific cases. For example, The chemotherapy for ALL and gemtuzuab ... If the patients enter fully remission, the consolidation with stem cell transplantation is highly recommended. The prognosis ... Usually the chemotherapy is chosen according to the morphology of the blast (ALL or AML). A blood-forming stem-cell ... Recently, researches showed that using both myeloid and lymphoid induction therapy may be better for prognosis.Chemotherapy has ...
Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is ... Chemotherapy. A woman being treated with docetaxel chemotherapy for breast cancer. Cold mittens and wine coolers are placed on ... The term chemotherapy[edit]. The word chemotherapy without a modifier usually refers to cancer treatment, but its historical ... Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall ...
Chemotherapy drugs often used to treat AML are Cytarabine and an anthracycline drug. Chemotherapy is broken down into 2 phases ... Consolidation Therapy: second phase given in cycles that occur after the patient has recovered from induction therapy. Its ... Multiple chemotherapy drugs and its effects are being research in comparison to its treatment success in AML not specifically ... The aggressive Chemotherapy regimen can lead to long term side effects such as prolonged anemia, leukocytopenia, neutropenia, ...
Chemotherapy is widely used as frontline treatment, and often is not repeated in relapse due to side effects. Alternate ... The phases of treatment are generally: frontline, following diagnosis, consolidation, after frontline response (to prolong ... A stronger chemotherapy with greater side effects (mostly hematologic) is HyperCVAD, often given in the hospital setting, with ... MCL cells may also be resistant to drug-induced apoptosis, making them harder to cure with chemotherapy or radiation. Cells ...
... acute myeloid leukemia is treated using chemotherapy consisting of an induction phase and consolidation phase (Dohner et al., ... adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of ...
Chemotherapy can be used alone or in combination with other therapies. Chemotherapy can be given either as a pill to swallow ... Consolidation/Intensification is used to kill any remaining cells that have the potential to become cancerous. It consists of ... "Chemotherapy to Treat Cancer". National Cancer Institute. 2015-04-29. Retrieved 2018-12-13. "High-dose Chemotherapy and Stem ... Consolidation begins after remission is obtained and is aimed at killing any remaining cancer cells. It will again vary ...
Consolidation/intensification Use high doses of chemotherapy to further reduce tumor burden Typical protocols use the following ... ChemotherapyEdit. Chemotherapy is the initial treatment of choice, and most people with ALL receive a combination of ... In general, cytotoxic chemotherapy for ALL combines multiple antileukemic drugs tailored to each person. Chemotherapy for ALL ... Chemotherapy, stem cell transplantation, radiation therapy, targeted therapy[1]. Prognosis. Children: 90% five-year survival ...
Cancer (2015 PBS film) History of cancer History of cancer chemotherapy The Emperor of All Maladies: A Biography of Cancer [1 ... There were four phases: remission induction, remission consolidation or intensification, specific pre-emptive meningeal ... treatment and continuation chemotherapy for 3 years. Both radiotherapy and instillation of drug directly into spinal fluid were ...
In the 2000 European APL study, the 2-year relapse rate for those that did not receive consolidation chemotherapy (ATRA not ... based chemotherapy. Both chemotherapies result in a clinical remission in approximately 90% of patients with arsenic trioxide ... Unlike other chemotherapies, ATRA does not directly kill the malignant cells. ATRA induces the terminal differentiation of the ... ATRA alone is capable of inducing remission but it is short-lived in the absence of concurrent "traditional" chemotherapy. As ...
... followed by consolidation chemotherapy and autologous hematopoietic stem cell transplantation. Brentuximab vedotin is a ... Previous chemotherapy treatment regimens that did not use autologous stem cell transplantation reported poor prognoses with ... Optimal treatment of EATL has used regimens consisting of intensive chemotherapy, hematopoietic stem cell transplantation and, ... to repair obstructed or perforated bowel or remove bulky disease followed by a conditioning regimen of high-dose chemotherapy ( ...
Consolidation treatment often entails a repetition of induction chemotherapy or the intensification chemotherapy with ... induction phase of chemotherapy. Such combination chemotherapy usually offers the benefits of early remission and a lower risk ... Consolidation therapy or intensification therapy to eliminate any remaining leukemia cells. There are many different approaches ... Dental work is recommended before chemotherapy or radiation therapy. Those in remission can be treated per normal. The success ...
Induction with chemotherapy (Daunorubicin + Cytarabine), followed by consolidation chemotherapy (High dose cytarabine). Stem ... Intensive chemotherapy phase for initial 6 months and maintenance chemotherapy for 2 years. Prophylactic cranial and stem cell ... Treatment options include radiation, chemotherapy, and surgery.[58]. Stomach cancer. Treatment options include chemotherapy, ... Chemotherapy with ABVD or BEACOPP regimen and Involved field radiation therapy (IFRT).[71]. Non-Hodgkin lymphoma (NHL). Chemo- ...
... two or more cycles of a platinum-based chemotherapy were randomly assigned to receive durvalumab or a placebo as consolidation ... or metastatic urothelial carcinoma who either have disease progression during or following platinum-containing chemotherapy or ... have disease progression within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy. ...
... chemotherapy), a chemotherapy regimen Institute for Learning, a defunct UK body intended to promote teaching Indian Federation ... advocated consolidation of the British Empire Intact forest landscape Integrated Facility for Linux, an IBM mainframe processor ...
... and continue it during the consolidation/intensification period. Adult chemotherapy regimens mimic those of childhood ALL; ... In general, cytotoxic chemotherapy for ALL combines multiple antileukemic drugs tailored to each person. Chemotherapy for ALL ... Treatment usually also include intrathecal chemotherapy since systemic chemotherapy can have limited penetration into the ... Chemotherapy is the initial treatment of choice, and most people with ALL receive a combination of medications. There are no ...
Two other studies that included bortezomib in their chemotherapy regimens likewise found that the addition of autologous stem- ... drug regimen such as borezomib-lenalidomide-dexamethasone followed by autologous stem-cell transplantion and consolidation/ ... In one study, patients receiving intensive chemotherapy plus autologous stem-cell transplantation had a median survival of 34 ... months while those receiving chemotherapy alone had a median survival of 11 months. ...
... pulmonary consolidation, a mass, or a nodule". Pathologically, a cavity is "usually produced by the expulsion or drainage of a ... if a lung cancer develops cavitation after chemotherapy and radiofrequency ablation, that indicates a good response to ...
... and resistance to chemotherapy. In response, Prophylactic Intrathecal Chemotherapy is further enhanced with CNS radiation ... The treatment typically takes place over three stages: induction, consolidation, and maintenance. Treatment is expected to span ... Henceforth, Prophylactic Intrathecal Chemotherapy in CNS lymphoma, a treatment to lower risk of leukemia spreading to the ... Currently, standard treatment of T-ALL takes the form of long-term chemotherapy and drug intake to prevent or treat side ...
... as consolidation of the remission status obtained following surgery and standard platinum and taxane first line chemotherapy.[ ... Nine hundred women in whom the ovarian tumour was removed by surgery and standard chemotherapy with paclitaxel and carboplatin ... In spite of initially successful treatment with surgery and chemotherapy, which forces back the tumour "completely", i.e. into ... Immunological consolidation of ovarian carcinoma recurrences with monoclonal anti-idiotype antibody ACA125: immune responses ...
... chrysotherapy climatotherapy cobalt therapy cold compression therapy combination therapy consolidation therapy contrast bath ... brachytherapy cardiac resynchronization therapy cell therapy cytotherapy cell transfer therapy chelation therapy chemotherapy ...
... known as consolidation chemotherapy. For people at high risk of relapse (e.g. those with high-risk cytogenetics, underlying MDS ... August 1999). "A randomized comparison of all transretinoic acid (ATRA) followed by chemotherapy and ATRA plus chemotherapy and ... The risk is highest about three to five years after chemotherapy. Other chemotherapy agents, specifically epipodophyllotoxins ... induction chemotherapy may not be offered to the very elderly, and the options may include less intense chemotherapy or ...
Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is ... Maintenance chemotherapy is a repeated low-dose treatment to prolong remission. Salvage chemotherapy or palliative chemotherapy ... Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall ... Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms. Induction chemotherapy ...
ADE is a chemotherapy regimen most often used as an induction or consolidation regimen in acute myelogenous leukemia, ... Fludarabine and cytosine are less effective than standard ADE chemotherapy in high-risk acute myeloid leukemia, and addition of ... regimen or who are relapsed after the standard chemotherapy. ADE regimen consists of three drugs: Ara-C (cytarabine) - an ...
... in combination with chemotherapy. The drug is approved for use with a companion diagnostic, the LeukoStrat CDx FLT3 Mutation ... high-dose C consolidation (consol), and as maintenance (maint) therapy in newly diagnosed acute myeloid leukemia (AML) patients ... was found to prolong survival of FLT3-mutated AML patients when combined with conventional induction and consolidation ...
It is also used second-line for relapsed/refractory neuroblastoma in combination with chemotherapy and GM-CSF. Dinutuximab beta ... It is given in patients who have completed induction therapy and consolidation therapy (autologous bone marrow transplant and ... Dinutuximab is used as post-consolidation therapy for children with high-risk neuroblastoma, in combination with granulocyte- ...
Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with ... "7+3" in the context of chemotherapy is an acronym for a chemotherapy regimen that is most often used today (as of 2014) as ... which is better treated with ATRA and/or arsenic trioxide and requires less chemotherapy (if requires it at all, which is not ... always the case). The name "7+3" comes from the duration of chemotherapy course, which consists of 7 days of standard-dose ...
It is mostly used as consolidation therapy for relapsed or refractory lymphomas and relapsed or refractory Hodgkin disease, ... Sequential high-dose chemotherapy is a chemotherapy regimen consisting of several (2 to 4) sequential monochemotherapies with ... The idea behind this approach is that when using single-agent chemotherapy, the doctor can easily escalate the dose of the drug ... Oyan B, Koc Y, Ozdemir E, Kars A, Turker A, Tekuzman G, Kansu E (2006). "High dose sequential chemotherapy and autologous stem ...
No signs and symptoms of lobar consolidation, meaning that the infection is restricted to small areas, rather than involving a ... Journal of Chemotherapy. 19 (Suppl 1): 17-23. PMID 18073166. [permanent dead link] Diseases Database Causes of atypical ... In addition, this form of pneumonia is atypical in presentation with only moderate amounts of sputum, no consolidation, only ... a dry irritating cough followed later by a productive cough with radiographs showing consolidation), there are in general few ...
Vertes, Robert P.; Eastman, KE (2000). "The case against memory consolidation in REM sleep". Behavioral and Brain Sciences. 23 ... "Tuberculosis chemotherapy with hydrazine derivatives of isonicotinic acid". Chest. 21 (4): 385-438. doi:10.1378/chest.21.4.385 ...
It is a condition where the alveoli are deflated down to little or no volume, as distinct from pulmonary consolidation, in ... If a tumor is blocking the airway, relieving the obstruction by surgery, radiation therapy, chemotherapy, or laser therapy may ...
Chemotherapy[edit]. The chemotherapy regimen depends on the tumor type.[6] Small-cell lung carcinoma (SCLC), even relatively ... consolidation (pneumonia) or pleural effusion.[7] CT imaging is typically used to provide more information about the type and ... Adjuvant chemotherapy refers to the use of chemotherapy after apparently curative surgery to improve the outcome. In NSCLC, ... Chemotherapy may be combined with palliative care in the treatment of the NSCLC. In advanced cases, appropriate chemotherapy ...
Their active immunotherapy, BiovaxID, is a cancer vaccine whose first indication is intended to be consolidation/adjuvant ... blood following chemotherapy, and improve the duration of complete remissions by a median of 15.4 months relative to control. ... and recruiting the patient's own immune system to destroy micro-pockets of cancer cells that may remain following chemotherapy ...
... such as chemotherapy) or in acute radiation syndrome (though deuterium is not radioactive), and is due to deuterium's action in ... and third phase saw consolidation and a shift towards improvement in production and energy conservation. ... As in chemotherapy, deuterium-poisoned mammals die of a failure of bone marrow (bleeding and infection) and intestinal-barrier ...
... such as chemotherapy) or in acute radiation syndrome (though deuterium is not radioactive), and is due to deuterium's action in ... and third phase saw consolidation and a shift towards improvement in production and energy conservation. ... As in chemotherapy, deuterium-poisoned mammals die of a failure of bone marrow (bleeding and infection) and intestinal-barrier ...
consolidation therapy A therapy given to consolidate the gains from induction therapy. In cancer, this means chasing after any ... by drugs: pharmacotherapy, chemotherapy (also, medical therapy often means specifically pharmacotherapy). *by medical devices: ... Often multiple therapies may be tried simultaneously (combination therapy or polytherapy). Thus combination chemotherapy is ... are called neoadjuvant chemotherapy, not premedication, whereas things like anesthetics or prophylactic antibiotics before ...
Memory consolidation.[31] Signals via Gi/o inhibition of adenylyl cyclase. ... The enterochromaffin cells not only react to bad food but are also very sensitive to irradiation and cancer chemotherapy. Drugs ... They are particularly important in treating the nausea and vomiting that occur during anticancer chemotherapy using cytotoxic ... Gonzalez R, Chávez-Pascacio K, Meneses A (September 2013). "Role of 5-HT5A receptors in the consolidation of memory". ...
In mice lacking SHARP1/BHLHE41 and SHARP2, IGF-2 is elevated and leads to enhanced memory consolidation.[29] ... Research is currently examining whether BHLHE40 and BHLHE41 can be used as target genes for chemotherapy.[34] ... "Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the ...
Treatment with chemotherapy has been used with some success, particularly using lomustine, prednisone, doxorubicin, and ... sometimes leading to lung lobe consolidation and pleural effusion.[6] Signs and symptoms include cough, loss of appetite, ...
Vertes, Robert P.; Eastman, KE (2000). "The case against memory consolidation in REM sleep". Behavioral and Brain Sciences 23 ( ... "Tuberculosis chemotherapy with hydrazine derivatives of isonicotinic acid". Chest 21 (4): 385-438. doi:10.1378/chest.21.4.385 ...
A randomized comparison of all transretinoic acid (ATRA) followed by chemotherapy and ATRA plus chemotherapy and the role of ... Core-binding factor acute myeloid leukemia: can we improve on HiDAC consolidation?. „Hematology Am Soc Hematol Educ Program". ... Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B. „N Engl J Med". 331 ( ... A tribute to Sidney Farber-- the father of modern chemotherapy. „Br J Haematol". 134 (1), s. 20-6, 2006. DOI: 10.1111/j.1365- ...
Pneumonia can be described as pneumonitis combined with consolidation and exudation of lung tissue due to infection with ... Possible causative agents include radiation therapy of the chest, exposure to medications used during chemo-therapy, the ... and chemotherapy drugs "Farmer's lung" and "hot tub lung" are common names for types of hypersensitivity pneumonitis that ...
In 1999 the Company led consolidation in the UK biosciences market merging with Chiroscience plc, after which it was briefly ... "Antibody-targeted chemotherapy with immunoconjugates of calicheamicin". Current Opinion in Pharmacology. 3 (4): 386-90. doi: ...
In mice lacking SHARP1/BHLHE41 and SHARP2, IGF-2 is elevated and leads to enhanced memory consolidation. There is a known amino ... Research is currently examining whether BHLHE40 and BHLHE41 can be used as target genes for chemotherapy. BHLHE41 is thought to ... Shahmoradi A, Radyushkin K, Rossner MJ (July 2015). "Enhanced memory consolidation in mice lacking the circadian modulators ...
Moran received a $447,000 debt consolidation loan at over 10% interest rate. The Lieutenant Governor of Virginia at the time, ... but after almost two years of chemotherapy and herbal therapies she was designated cancer free. His brother, Brian Moran, is a ...
... as Consolidation After CAF in High-Risk Primary Breast Cancer Involving Ten or More Axillary Lymph Nodes (LN): Preliminary ... The high-dose chemotherapy resulted in a significantly low relapse rate, and high-dose chemotherapy was associated with ... High-dose chemotherapy and bone marrow transplant (HDC/BMT), also high-dose chemotherapy with autologous bone marrow transplant ... 2003). "Conventional Adjuvant Chemotherapy with or without High-Dose Chemotherapy and Autologous Stem-Cell Transplantation in ...
The unification of the two hospitals was one of the most significant consolidations ever achieved by hospitals; it was in ... despite his own oncologist at Cedars-Sinai having recommended that he use the marijuana for his pain and chemotherapy. Dr. ...
Consolidation Chemotherapies. All MeSH CategoriesAnalytical, Diagnostic and Therapeutic Techniques and Equipment Category ... Consolidation Chemotherapy. Drug treatment designed to further diminish the disease toward complete remission following ... It helps to consolidate the gains during induction chemotherapy and may be followed by MAINTENANCE CHEMOTHERAPY. ...
consolidation chemotherapy synonyms, consolidation chemotherapy pronunciation, consolidation chemotherapy translation, English ... dictionary definition of consolidation chemotherapy. n. 1. The treatment of cancer using specific chemical agents or drugs that ... Related to consolidation chemotherapy: induction chemotherapy, salvage chemotherapy, platinum chemotherapy che·mo·ther·a·py. ( ... chemotherapy. (redirected from consolidation chemotherapy). Also found in: Thesaurus, Medical, Encyclopedia. ...
A 64-year-old man with acute myelogenous leukemia (FAB classification, M7) in remission received consolidation chemotherapy ... Bacillus cereus sepsis and subarachnoid hemorrhage following consolidation chemotherapy for acute myelogenous leukemia].. [ ... which developed at nadir following chemotherapy for leukemia patients. Because of the aggressive clinical course of B. cereus ... cereus sepsis would be important in the management of leukemia patients after chemotherapy. ...
Venetoclax in Combination With Intensive Induction and Consolidation Chemotherapy in Treatment Naïve AML. The safety and ... Phase 1b Study of Venetoclax in Combination With Intensive Induction and Consolidation Chemotherapy in Treatment Naïve Subjects ... of combining venetoclax with standard induction and consolidation chemotherapy for AML.. *Partial Response Rate [ Time Frame: 2 ... response rate data as to the efficacy of combining venetoclax with standard induction and consolidation chemotherapy for AML. ...
Experimental: Radiochemotherapy -, chemotherapy. Radiochemotherapy followed by consolidation chemotherapy. Deep regional ... Organ Preservation in Locally Advanced Rectal Cancer by Radiochemotherapy Followed by Consolidation Chemotherapy. (CAO/ARO/AIO- ... Organ Preservation in Locally Advanced Rectal Cancer by Radiochemotherapy Followed by Consolidation Chemotherapy. A Prospective ... Drug: Chemotherapy chemoradiotherapy is started according to the following schedule: 5-FU: 250 mg/sqm per day, iv, on day 1-14 ...
... it is not yet known whether chemotherapy and radiation therapy are more effective when given with consolidation chemotherapy in ... Trial of Postoperative Chemoradiotherapy With or Without Consolidation Chemotherapy for Cervical Cancer Patients. The safety ... The purpose of this study is to determine the efficacy and safety of consolidation chemotherapy with paclitaxel plus cisplatin ... Phase III Randomized Study of Concurrent Paclitaxel/Cisplatin Chemotherapy and Radiotherapy With or Without Consolidation ...
Consolidation chemotherapy After neoadjuvant chemoradiotherapy, patients will receive three cycles of chemotherapy. Thereafter ... Consolidation Chemotherapy for Locally Advanced Mid or Low Rectal Cancer After Neoadjuvant Concurrent Chemoradiotherapy. The ... KCSP Trial of cONsolidation Chemotherapy for Locally Advanced Mid or Low Rectal Cancer After neoadjUvant Concurrent ... Korean Society of Coloproctology (KSCP) trial of cONsolidation Chemotherapy for Locally advanced mid or low rectal cancer after ...
... standard DA consolidation treatment of acute myeloid leukemia ... of this study is to determine whether Azacitidine consolidation ... Azacitidine Compared to Conventional Chemotherapy in Consolidation of Elderly Patients (65 Years or Older) With AML in First ... Azacitidine Compared to Conventional Chemotherapy in Consolidation of Elderly Patients (65 Years or Older) With AML in First ... 1. Subjects who are not considered to be candidates to complete the consolidation. therapy due to medical or psychological ...
A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid ... A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid ... parameters of ASP2215 concomitant with induction and consolidation chemotherapy as well as evaluate the PK parameters of ... Treatment of AML in Phase 1 part is composed of 3 periods of therapy: remission induction, consolidation, and maintenance. The ...
Announces Updated Data from Phase 1 Study of Ivosidenib or Enasidenib in Combination with Standard Induction and Consolidation ... Chemotherapy in Newly Diagnosed AML Patients With an IDH Mutation ... received up to four cycles of consolidation chemotherapy while ... "These data demonstrate that combining full doses of standard induction and consolidation chemotherapy with ivosidenib or ... registration-enabling trial combining ivosidenib or enasidenib with standard induction and consolidation chemotherapy followed ...
HEAD START 4: A Study of Different Regimens of Induction and Consolidation Chemotherapy with Stem Cell Rescue for Children ... Clinical and Molecular Risk-Tailored Intensive and Compressed Induction Chemotherapy Followed by Consolidation with ... patients will be randomly assigned to receive either one or three cycles of consolidation chemotherapy. Children with low-risk ... After the stem cells have been collected, they will be stored and then given again after the consolidation phase, to help the ...
Treatment of children with AML in first remission with either autologous bone marrow transplantation or intensive chemotherapy ... We compared autologous bone marrow transplantation with intensive consolidation chemotherapy as treatments for children with ... Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood. ... The event-free survival at three years for the nonrandomized intensive-chemotherapy group was 39 +/- 5.1 percent, and for a ...
Myeloablative chemotherapy with autologous stem-cell transplantation improves the outcome for children with high-risk ... Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in ... Interpretation: Myeloablative chemotherapy with autologous stem-cell transplantation improves the outcome for children with ... or to oral maintenance chemotherapy with cyclophosphamide (n=146). The primary endpoint was event-free survival. Secondary ...
Bone marrow transplantation versus high-dose cytarabine-based consolidation chemotherapy for acute myelogenous leukemia in ... cytarabine-based consolidation chemotherapy. Results:. After a median follow-up of 4 years, the actuarial risk of leukemic ... In this study we analyzed the results of one or more cycles of high-dose cytarabine-based consolidation chemotherapy as ... relapse was considerably lower in the transplant group than in the group treated with consolidation chemotherapy (32% +/- 26% v ...
The intensified treatment paradigm of XELOX concurrent chemoradiation followed by one cycle of consolidation chemotherapy was ... of intensified full-dose XELOX chemotherapy concomitant to radiotherapy and then resting-period consolidation chemotherapy in ... The intensified treatment paradigm of XELOX concurrent chemoradiation followed by one cycle of consolidation chemotherapy was ... More News: Adenocarcinoma , Cancer , Cancer & Oncology , Chemotherapy , Eloxatin , Intensity-Modulated Radiation Therapy , ...
Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation/ ... and in elderly patients in combination with conventional chemotherapy and as consolidation/maintenance therapy in young and ... Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation/ ... "Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation/ ...
Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute ... Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute ... Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute ... LR-ALL patients were randomized to receive or not early consolidation chemotherapy (C-1). After receiving C-1, IR patients were ...
A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With ... A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With ... as a chemotherapy backbone onto which a companion immunotherapy protocol will be offered.. An identical chemotherapy regimen ... Patients will then receive consolidation therapy with. three cycles of high-dose alkylating agents. First, patients will ...
Syed A. Abutalib, MD, and Nelli Bejanyan, MD, on Adult ALL and Consolidation Chemotherapy: Results From a CIBMTR Study 2016 ASH ...
... consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 ... designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, ... Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed FLT3 Mutated ... consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 ...
... and intensive consolidation chemotherapy (CCT). Assessment was made by patient questionnaire via the treating centers for ... compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. ... and intensive consolidation chemotherapy (CCT). Assessment was made by patient questionnaire via the treating centers for ... compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. ...
Consolidation treatment for AML is given soon after induction treatment to keep leukemia cells from coming back. Learn about ... Chemotherapy. Chemotherapy is the main consolidation treatment for AML. Chemotherapy is given soon after remission has been ... A targeted therapy drug called a tyrosine kinase inhibitor may be added to the consolidation chemotherapy regimen for people ... Consolidation treatments for acute myelogenous leukemia. Consolidation treatment is also called post-remission therapy. The ...
... chemotherapy is often the preferred method of treatment. Learn more about chemotherapy drugs used to treat multiple myeloma. ... Canadian Cancer Society: "Chemotherapy for Multiple Myeloma," "Consolidation therapy for multiple myeloma," "Induction therapy ... Other Drugs Given With Chemotherapy. Some medicines help chemotherapy drugs work better. For instance:. *Corticosteroids( ... Many people get chemotherapy in cycles. If the doctor decides this is right for you, youll get medicine for several days in a ...
Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy in patients ... N2 - Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy in ... AB - Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy in ... abstract = "Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy ...
Sandra Kurtin, an expert on acute myeloid leukemia (AML), describes the induction and consolidation phases of chemotherapy ... Once the blast numbers are reduced, you have additional chemotherapy called "consolidation" to make sure the levels of these ... Expert Video - What are induction and consolidation chemotherapy for AML?. Dr. ... The first phase of treatment is called induction chemotherapy. It is designed to eliminate the blasts, or abnormal cells, that ...
Consolidation After Induction Chemotherapy. Several phase II studies have investigated consolidation with intensive ... Chemotherapy Alone. Trials using chemotherapy alone were justified because of the unsatisfactory results using WBRT alone, and ... the role of consolidation treatment after a complete response to high-dose methotrexate-based chemotherapy. Cancer 113 (5): ... Omuro A, Correa DD, DeAngelis LM, et al.: R-MPV followed by high-dose chemotherapy with TBC and autologous stem-cell transplant ...
Chemotherapy consisted of 3 to 6 cycles of a platinum-paclitaxel regimen in 18 patients. WAI was delivered using conventional ... Consolidative WAI following chemotherapy is feasible and can be performed without interruption with manageable acute and late ... No grade 4 toxicities occurred during chemotherapy or radiotherapy. No radiation dose reduction was necessary. Three patients ... had favorable outcomes possibly meriting prospective evaluation of the addition of WAI following chemotherapy in selected ...
Latest: FDA Approves Adcetris (brentuximab vedotin) in Combination with Chemotherapy for Adults with Previously Untreated ... Classical Hodgkin Lymphoma Consolidation. 1.8 mg/kg up to a maximum of 180 mg. Intravenous infusion over 30 minutes. Initiate ... cHL consolidation. Adcetris is indicated for the treatment of adult patients with cHL at high risk of relapse or progression as ... Table 10: Efficacy Results in Patients with Classical Hodgkin Lymphoma Post-auto-HSCT Consolidation (Study 3: AETHERA). * Not ...
Table 10: Efficacy Results in Patients with Classical Hodgkin Lymphoma Post-auto-HSCT Consolidation (Study 3: AETHERA). ... 1.2 mg/kg up to a maximum of 120 mg in combination with chemotherapy. Intravenous infusion over 30 minutes. Administer every 2 ... Classical Hodgkin Lymphoma Consolidation. 1.8 mg/kg up to a maximum of 180 mg. Intravenous infusion over 30 minutes. Initiate ... cHL consolidation. ADCETRIS is indicated for the treatment of adult patients with cHL at high risk of relapse or progression as ...
Chemotherapy safety. *Learn how to keep you and your family safe while you are having anticancer drugs. ... Consolidation 5-2 ida (cytarabine, idarubicin). This treatment may be given for up to two cycles. Your doctor will advise you ... This treatment involves having chemotherapy through a central venous access device (CVAD). Your doctor or nurse will explain ... Ask your doctor or nurse for eviQ patient information - Memory changes and chemotherapy (chemo brain). ...
  • Drug treatment designed to further diminish the disease toward complete remission following INDUCTION CHEMOTHERAPY. (nih.gov)
  • A 64-year-old man with acute myelogenous leukemia (FAB classification, M7) in remission received consolidation chemotherapy with mitoxantrone/cytosine arabinoside. (nih.gov)
  • 1. To obtain preliminary data as to the efficacy (Complete Remission (CR), Complete remission with incomplete platelet recovery (CRp), Complete remission with incomplete hematologic recovery (CRi), and minimal residual disease (MRD) negative CR) of combining venetoclax with standard induction and consolidation chemotherapy for AML. (clinicaltrials.gov)
  • Treatment of AML in Phase 1 part is composed of 3 periods of therapy: remission induction, consolidation, and maintenance. (centerwatch.com)
  • We compared autologous bone marrow transplantation with intensive consolidation chemotherapy as treatments for children with AML in first remission. (nih.gov)
  • Treatment of children with AML in first remission with either autologous bone marrow transplantation or intensive chemotherapy prolongs event-free survival equally. (nih.gov)
  • In this study we analyzed the results of one or more cycles of high-dose cytarabine-based consolidation chemotherapy as compared with allogeneic BMT in first remission. (uni-bonn.de)
  • The results in 28 adult patients, aged 16 to 45 years, who underwent a closely HLA-matched BMT for AML in first remission were compared with those in 54 consecutive, age-matched, adult patients treated with one or more cycles of high-dose, cytarabine-based consolidation chemotherapy. (uni-bonn.de)
  • Our results show that BMT in first remission AML did not offer a disease-free survival advantage over intensive postremission consolidation chemotherapy. (uni-bonn.de)
  • METHODS: A cross-sectional study of sexual health and infertility was conducted in 479 patients with acute myeloid leukemia (AML) in first complete remission (CR) who were entered into the UK MRC AML 10 trial comparing allogeneic BMT (Allo-BMT), autologous BMT (A-BMT), and intensive consolidation chemotherapy (CCT). (ox.ac.uk)
  • Consolidation treatment is also called post-remission therapy. (cancer.ca)
  • Chemotherapy is given soon after remission has been reached (2-3 weeks after blood cell counts return to normal). (cancer.ca)
  • Once your leukemia is in remission, the next phase of treatment is consolidation. (ahealthyme.com)
  • Consolidation treatment was associated with very low toxicity and no deaths in remission were recorded. (bloodjournal.org)
  • 2 (2) The best therapy results, in terms of complete remission (CR) and disease-free survival (DFS), have been obtained using ATRA and chemotherapy for remission induction. (bloodjournal.org)
  • Chemotherapy and adequate supportive care results in complete remission rates of about 98% for children and 85% for adults. (news-medical.net)
  • Common regimens for consolidation in childhood ALL include high dose methotrexate with mercaptopurine, high dose asparaginase over an extended period and a repetition of the initial induction therapy in the first few months of remission. (news-medical.net)
  • The treatment of acute myeloid leukemia (AML) is divided into two phases: remission induction and consolidation/maintenance. (texasoncology.com)
  • Remission induction chemotherapy is administered to produce a complete remission in the bone marrow. (texasoncology.com)
  • To prevent recurrence of leukemia, intensive therapy, called consolidation, is given immediately after recovery from remission induction therapy. (texasoncology.com)
  • Patients with newly diagnosed AML who achieve a complete remission following remission induction therapy have historically been advised to receive consolidation treatment with either high-dose chemotherapy supported by an allogeneic HLA-matched sibling stem cell transplant, high-dose chemotherapy and autologous stem cell transplant, or conventional-dose chemotherapy delivered without stem cell support. (texasoncology.com)
  • Of the 65 patients achieving the first complete remission from 1992 to 1997, 33 patients were treated with 3 courses of consolidation chemotherapies and 32 with the stem cell transplantation . (bvsalud.org)
  • These data demonstrate that the stem cell transplantation results in better leukemia -free survival than the consolidation chemotherapy for patients with APL in the first complete remission because of lower risk of relapse . (bvsalud.org)
  • Thirty seven of them (74%) went into complete remission (CR) and they all then received two consecutive courses of consolidation chemotherapy consisting of cytosine arabinoside 500 mg/m 2 per day by 1 h i.v, infusion every 12 h for 4 days (total eight doses) and mitoxantrone 12 mg/m 2 daily by 30 min i.v. infusion for 3 days. (hku.hk)
  • Treatment of acute myeloid leukemia (AML) with chemotherapy may be classified into two phases: induction of remission and post-remission therapy. (news-medical.net)
  • Once complete remission is achieved, post remission therapy is started and it involves consolidation therapy and maintenance. (news-medical.net)
  • While induction chemotherapy aims to lower the number of AML cells, the main aim of post remission therapy is to prevent disease recurrence. (news-medical.net)
  • The goal of chemotherapy is to damage or kill cancer cells so there's either no sign of illness (remission) or the disease's progress is slowed. (lls.org)
  • Chemotherapy can produce long-term remission or outright cure for many persons, depending on the cancer type and its extent. (lls.org)
  • Post-remission therapy of adult acute myeloid leukemia: high dose cytosine-arabinoside versus other consolidation regimens/Konsolidaciona terapija akutne mijeloidne leukemije: visoke doze citozinarabinozida naspram drugih konsolidacionih rezima sa citozin-arabinozidom. (thefreelibrary.com)
  • ATRA alone can often put APL into remission, but combining it with chemotherapy (usually daunorubicin and cytarabine) gives better long-term results. (cancer.org)
  • Remission induction therapy uses chemotherapy to kill the existing leukemia cells in your body. (healthline.com)
  • Consolidation therapy, which is also known as post-remission therapy, is crucial for keeping AML in remission and preventing a relapse. (healthline.com)
  • The customary treatment for AML involves an initial "induction" phase that uses a combination of chemotherapy agents to put the disease into a first remission. (bio-medicine.org)
  • When should patients receive consolidation chemotherapy before allogeneic hematopoietic cell transplantation for acute myeloid leukemia in first complete remission? (lww.com)
  • After the disease is in remission, they are then given consolidation therapy. (mskcc.org)
  • More than 3 decades ago, the first trials of autologous hematopoietic cell transplantation as consolidation therapy for acute myeloid leukemia (AML) in first remission were conducted. (ascopost.com)
  • Although in remission, Leukemia cells can "hide" in your blood stream even after chemotherapy. (caringbridge.org)
  • The goals of induction therapy are to put your leukemia in remission and ensure you are healthy enough to go on to the next phase, consolidation therapy. (seattlecca.org)
  • The aim of this study was to evaluate the role of consolidation radiotherapy (RT) in advanced-stage Hodgkin's disease (HD) with initial bulky sites after radiological complete remission (CR) or partial response (PR) with positron emission tomography-negative (metabolic CR) following standard chemotherapy (ABVD [Adriamycin, bleomycin, vinblastine, and dacarbazine]) six to eight cycles. (dovepress.com)
  • OBJECTIVES: - Determine, preliminarily, the safety of incorporating arsenic trioxide (ATO) into cytarabine and daunorubicin hydrochloride-based consolidation therapy followed by tretinoin maintenance therapy in patients receiving induction tretinoin and daunorubicin hydrochloride with acute promyelocytic leukemia (APL) induced into remission with tretinoin and daunorubicin hydrochloride. (ichgcp.net)
  • Once a remission has been achieved, more chemotherapy is given to try to prevent the leukaemia from returning (relapsing). (leukaemia.org.au)
  • This is called post-remission or consolidation therapy. (leukaemia.org.au)
  • Concurrent radiotherapy with cisplatin-based chemotherapy has become the standard treatment for patients with cervical cancer. (clinicaltrials.gov)
  • Therefore, the investigators are going to perform the efficacy and safety study of postoperative concurrent paclitaxel/cisplatin chemotherapy and radiotherapy with consolidation chemotherapy in high-risk patients with early-stage cervical cancer following radical hysterectomy. (clinicaltrials.gov)
  • Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy in patients with locally advanced non-small-cell lung cancer (NSCLC) are unknown. (elsevier.com)
  • Seung, SK & Ross, HJ 2009, ' Phase II Trial of Combined Modality Therapy With Concurrent Topotecan Plus Radiotherapy Followed by Consolidation Chemotherapy for Unresectable Stage III and Selected Stage IV Non-Small-Lung Cancer ', International Journal of Radiation Oncology Biology Physics , vol. 73, no. 3, pp. 802-809. (elsevier.com)
  • Before transplantation can take place, the person receiving the transplant will be given aggressive high-dose chemotherapy and radiotherapy to destroy any cancerous cells in their body. (news-medical.net)
  • Additionally, chemotherapy and/or radiotherapy have shown the roles to improve oncologic outcomes by controlling local recurrence. (beds.ac.uk)
  • So far, no reliable molecular or pathologic biomarkers to foster pathologic complete response (pCR), which means complete regression of the tumor after radiotherapy and/or chemotherapy, was identified. (beds.ac.uk)
  • We suggest that high-dose MVP chemotherapy followed by an early response-adapted intensification strategy may be effective and minimize the number of patients who receive radiotherapy or ASCT in the early course of treatment. (yonsei.ac.kr)
  • We analyzed the safety and feasibility of preoperative short-course radiotherapy (SCRT) followed by consolidation chemotherapy for patients with locally advanced rectal cancer (LARC). (researchsquare.com)
  • PMID 6406037 , 1983 (1974-78) - "A randomized study of radiotherapy versus radiotherapy plus chemotherapy in stage I-II non-Hodgkin's lymphomas. (wikibooks.org)
  • One hundred and thirteen patients who received radiotherapy (RT) as consolidation postchemotherapy (RT group) were compared to 79 patients who did not receive RT (non-RT group). (dovepress.com)
  • In the study, adult patients under 60 years of age with newly-diagnosed FLT3-mutated acute myeloid leukemia (AML) who received the investigational compound PKC412 (midostaurin) plus standard induction and consolidation chemotherapy experienced a 23% improvement in overall survival (OS) (hazard ratio HR = 0. (thefreedictionary.com)
  • Fatal subarachnoid hemorrhage has been reported to be associated with B. cereus sepsis, which developed at nadir following chemotherapy for leukemia patients. (nih.gov)
  • Because of the aggressive clinical course of B. cereus sepsis, including the risk for subarachnoid hemorrhage, early treatment with effective antibiotics for B. cereus sepsis would be important in the management of leukemia patients after chemotherapy. (nih.gov)
  • A standardized re-evaluation after consolidating chemotherapy will select patients who are candidates for organ-preservation. (clinicaltrials.gov)
  • After neoadjuvant chemoradiotherapy, patients will receive surgery followed by eight cycles of chemotherapy. (clinicaltrials.gov)
  • After neoadjuvant chemoradiotherapy, patients will receive three cycles of chemotherapy. (clinicaltrials.gov)
  • A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid Leukemia. (centerwatch.com)
  • SAN DIEGO, Dec. 03, 2018 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (NASDAQ:AGIO), a leader in the field of cellular metabolism to treat cancer and rare genetic diseases, today presented data from a Phase 1 study evaluating ivosidenib or enasidenib in combination with standard induction and consolidation chemotherapy in patients with newly diagnosed acute myeloid leukemia (AML) and an isocitrate dehydrogenase (IDH)1 or IDH2 mutation. (tmcnet.com)
  • These data demonstrate that combining full doses of standard induction and consolidation chemotherapy with ivosidenib or enasidenib is well tolerated and has the potential to provide benefit for AML patients in the frontline setting," said Eytan Stein, M.D., study investigator and attending physician in the leukemia service at Memorial Sloan Kettering Cancer Center. (tmcnet.com)
  • The addition of an IDH inhibitor to induction and consolidation followed administration as single-agent maintenance therapy for patients with newly diagnosed AML will be evaluated further in a Phase 3 randomized study. (tmcnet.com)
  • HOVON 150 AML/AMLSG 29-18 is an intergroup sponsored, global, registration-enabling trial combining ivosidenib or enasidenib with standard induction and consolidation chemotherapy followed by a maintenance therapy period in frontline AML patients with an IDH1 or IDH2 mutation, respectively. (tmcnet.com)
  • As of the August 1, 2018 data cut-off, 60 newly diagnosed AML patients with mIDH1 received 500 mg of ivosidenib and standard induction chemotherapy (daunorubicin 60 mg/m2/day or idarubicin 12 mg/m2/day x 3 days with cytarabine 200 mg/m2/day x 7 days) and 93 newly diagnosed AML patients with mIDH2 received 100 mg of enasidenib and standard induction chemotherapy. (tmcnet.com)
  • After induction, patients received up to four cycles of consolidation chemotherapy while continuing ivosidenib (n=28) or enasidenib (n=45). (tmcnet.com)
  • Patients who achieved a complete response (CR) or a complete response with incomplete neutrophil or platelet recovery (CRi/CRp) after consolidation could continue taking single agent ivosidenib or enasidenib daily until the end of the study which is up to two years from the last patient dosed. (tmcnet.com)
  • Patients will receive three cycles of chemotherapy (five if there is still residual tumor remaining after three cycles). (mskcc.org)
  • Based on the results of the tumor marker tests, patients will be randomly assigned to receive either one or three cycles of consolidation chemotherapy. (mskcc.org)
  • Patients may not have previously received chemotherapy or radiation therapy. (mskcc.org)
  • Patients who had surgery to remove their cancer must begin induction chemotherapy within 4 weeks of the surgical procedure. (mskcc.org)
  • of the remaining 343 patients, 232 were randomly assigned to receive six courses of intensive chemotherapy (117 patients) or autologous transplantation (115 patients). (nih.gov)
  • Of the original 649 patients, 189, including 21 with Down's syndrome, were nonrandomly assigned to receive intensive chemotherapy. (nih.gov)
  • The event-free survival at three years for the nonrandomized intensive-chemotherapy group was 39 +/- 5.1 percent, and for a contemporaneous group of patients each of whom received a histocompatible bone marrow transplant from a sibling, it was 52 +/- 8.0 percent. (nih.gov)
  • Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation/Maintenance Treatment in Young and Elderly Patients : 3 Randomized Studies. (bioportfolio.com)
  • multiple myeloma as induction treatment in young patients, with Dexamethasone before autotransplant, and in elderly patients in combination with conventional chemotherapy and as consolidation/maintenance therapy in young and elderly patients at plateau-phase. (bioportfolio.com)
  • LR-ALL patients were randomized to receive or not early consolidation chemotherapy (C-1). (haematologica.org)
  • After receiving C-1, IR patients were randomized to receive or not delayed consolidation chemotherapy (C-2). (haematologica.org)
  • HR patients received C-1 and C-2 chemotherapy. (haematologica.org)
  • Standard maintenance chemotherapy was administered to all patients for 2 years. (haematologica.org)
  • For IR patients, EFS and OS were significantly improved in those receiving early and delayed consolidation (EFS 87% (74-88) vs. 52% (41-70), and OS 92% (87-97) vs. 61% (51-71)(p=0.036). (haematologica.org)
  • Patients will then receive consolidation therapy with three cycles of high-dose alkylating agents. (knowcancer.com)
  • For high-risk stage II and III patients, this chemotherapy regimen (without genetic manipulation of PBPCs) will serve as a chemotherapy backbone onto which a companion immunotherapy protocol will be offered. (knowcancer.com)
  • An identical chemotherapy regimen will be offered to stage four patients as a backbone for a trial of retroviral transduction of the MDR1 and NeoR genes into harvested PBPCs. (knowcancer.com)
  • Patients without progression underwent consolidation chemotherapy with etoposide and a platinum agent for one cycle followed by two cycles of docetaxel. (elsevier.com)
  • Results: Of the 20 patients, 19 completed induction chemoradiotherapy and 13 completed consolidation. (elsevier.com)
  • Adcetris is indicated for the treatment of adult patients with previously untreated Stage III or IV cHL, in combination with chemotherapy. (drugs.com)
  • Adcetris is indicated for the treatment of adult patients with cHL at high risk of relapse or progression as post-autologous hematopoietic stem cell transplantation (auto-HSCT) consolidation. (drugs.com)
  • Adcetris is indicated for the treatment of adult patients with cHL after failure of auto-HSCT or after failure of at least two prior multi-agent chemotherapy regimens in patients who are not auto-HSCT candidates. (drugs.com)
  • ZARXIO is indicated for reducing the time to neutrophil recovery and the duration of fever, following induction or consolidation chemotherapy treatment of patients with acute myeloid leukemia ( AML ) [see Clinical Studies ]. (rxlist.com)
  • ZARXIO is indicated to reduce the duration of neutropenia and neutropenia-related clinical sequelae ‚ e.g.‚ febrile neutropenia, in patients with nonmyeloid malignancies undergoing myeloablative chemotherapy followed by bone marrow transplantation [see Clinical Studies ]. (rxlist.com)
  • Patients in CR received 3 monthly chemotherapy courses: idarubicin 5 mg/m 2 /d × 4 (course no. 1), mitoxantrone 10 mg/m 2 /d × 5 (course no. 2), and idarubicin 12 mg/m 2 /d × 1 (course no. 3). (bloodjournal.org)
  • Molecular assessment of response by reverse transcriptase-polymerase chain reaction (RT-PCR) showed conversion to PCR-negative in 48 of 99 (51%) and 82 of 88 patients (93%) after induction and consolidation, respectively. (bloodjournal.org)
  • 120 days) on survival among patients with stage I to III breast cancer treated with surgery and adjuvant chemotherapy from 2010 to 2014. (thefreedictionary.com)
  • Bone marrow and stem cell transplants are an alternative option in patients who do not respond to chemotherapy. (news-medical.net)
  • Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. (naver.com)
  • Patients currently receive one of these consolidation treatment strategies based on their perceptions of the outcomes associated with each treatment, the availability of an HLA-matched sibling stem cell donor, their physician's bias concerning the appropriateness of each treatment option, and the geographic availability of each treatment. (texasoncology.com)
  • Patients under age 60 without an allogeneic donor were treated with either autologous stem cell transplantation, or non-stem cell supported conventional-dose chemotherapy consolidation. (texasoncology.com)
  • The patients treated with allogeneic or autologous stem cell transplantation were more likely to be cured of their disease than the patients receiving conventional-dose consolidation chemotherapy. (texasoncology.com)
  • Evaluation at 4 years from initial treatment revealed that patients treated with allogeneic stem cell transplantation had a 55% chance of being alive without evidence of disease recurrence and patients treated with autologous stem cell transplantation had a 48% chance of being alive without evidence of disease recurrence, compared to only 30% for patients treated with conventional-dose consolidation chemotherapy. (texasoncology.com)
  • The objectives of this study were to evaluate long-term results of concurrent chemoradiotherapy (CRT) with 5-fluorouracil and cisplatin and the potential benefit of consolidation chemotherapy in patients with anal squamous cell carcinoma (ASCC). (beds.ac.uk)
  • Nineteen patients (90.5%) completed all four courses of consolidation chemotherapy. (beds.ac.uk)
  • No differences in 5-year OS and DFS rates between patients treated with CRT alone and CRT with consolidation chemotherapy was observed. (beds.ac.uk)
  • We compared the leukemia -free survival and overall survival between APL patients receiving the consolidation chemotherapy and those undergoing the allogeneic or autologous stem cell transplantation following the high- dose anticancer therapy . (bvsalud.org)
  • Several efforts have been tried to improve survival of patients who treated with neoadjuvant CRT and to achieve more pCR including adding cytotoxic chemotherapeutic agents, chronologic modification of chemotherapy schedule or adding chemotherapy during the perioperative period. (beds.ac.uk)
  • KONCLUDE trial aims to investigate whether consolidation chemotherapy shows better pCR and 3-year DFS than adjuvant chemotherapy alone for the patients who received neoadjuvant CRT for locally advanced rectal cancer. (beds.ac.uk)
  • YUHSpace: Early response to high-dose methotrexate, vincristine, and procarbazine chemotherapy-adapted strategy for primary CNS lymphoma: no consolidation therapy for patients achieving early complete response. (yonsei.ac.kr)
  • In this study, we investigated the treatment outcomes and prognostic factors of high-dose methotrexate, vincristine, and procarbazine (MVP) chemotherapy followed by an interim response-adapted intensification strategy in immunocompetent patients with PCNSL. (yonsei.ac.kr)
  • Ten (25 %) patients who achieved complete response (CR) in the interim analysis did not receive any additional consolidation treatment after completion of planned high-dose MVP chemotherapy. (yonsei.ac.kr)
  • Patients achieving a complete response (CR) were given an attenuated consolidation course. (edu.au)
  • Purpose: A phase II trial was conducted to evaluate the therapeutic efficacy and safety profiles of frontline concurrent chemoradiotherapy (CCRT) plus consolidation chemotherapy for patients with stage I/II nasal natural killer/T-cell lymphoma (NKTCL). (ncku.edu.tw)
  • Results: Thirty-three patients received CCRT, and 29 patients received two cycles of consolidation DVIP after CCRT. (ncku.edu.tw)
  • Age of patients and number of courses of induction chemotherapy to achieve CR were significant factors predicting DFS. (hku.hk)
  • Ten patients had prolonged marrow suppression following consolidation chemotherapy. (hku.hk)
  • From April 2018 to May 2019, 19 patients with LACR were treated with SCRT followed by three cycles of consolidation chemotherapy with leucovorin, fluorouracil, and oxaliplatin (FOLFOX6) before surgery. (researchsquare.com)
  • Five patients required dose reductions in consolidation chemotherapy. (researchsquare.com)
  • Preoperative SCRT followed by oxaliplatin-based consolidation chemotherapy showed acceptable toxicity and feasibility in patients with LARC. (researchsquare.com)
  • In case of younger patients, key options for consolidation therapy are (a) multiple cycles of high-intensity chemotherapy using cytarabine and (b) allogeneic or autologous stem cell transplant. (news-medical.net)
  • The progress in treatment and survival for patients with blood cancers is largely due to the development of chemotherapy drugs over the past 40 years. (lls.org)
  • The efficacy and safety of lenalidomide (LEN) consolidation therapy and subsequent LEN maintenance therapy after high-dose therapy with autologous peripheral blood stem cell transplantation (auto-PBSCT) were evaluated in patients with newly diagnosed symptomatic multiple myeloma (MM). Forty-one patients were enrolled and received high-dose dexamethasone (DEX) therapy as an initial induction. (springer.com)
  • One hundred days after auto-PBSCT, patients received consolidation therapy consisting two cycles of LEN plus low-dose DEX (Ld) and LEN maintenance therapy. (springer.com)
  • These observations suggest that LEN consolidation and maintenance therapy are effective and safe, and provide favorable response rates in patients with MM. (springer.com)
  • The objective of this study was to compare the survival rate and the relapse rate among the patients who received HDAC during consolidation therapy and among the patients who did not receive HDAC during consolidation therapy. (thefreelibrary.com)
  • The introduction of all- trans retinoic acid (ATRA) therapy resulted in terminal differentiation of APL cells and a 90-95% CR rate in patients ( 1 , 4 ), and subsequent combination of ATRA with chemotherapy raised the 5-year disease-free survival (DFS) rate up to 74% ( 5 ). (pnas.org)
  • In a previous study with a median follow-up of 18 months, we randomized patients to receive either ATRA or ATO singly, or ATRA/ATO-based regimens incorporating chemotherapy treatment as a frontline therapy for new APL cases. (pnas.org)
  • The first phase of treatment, called induction chemotherapy, requires that patients remain in the hospital for approximately four weeks. (ucsfhealth.org)
  • Once patients have completed intensive chemotherapy, they need to take oral chemotherapy pills for an additional 18 to 24 months. (ucsfhealth.org)
  • Patients need to have their blood tests checked once a month while taking chemotherapy pills. (ucsfhealth.org)
  • Patients are routinely given six or more injections of intrathecal chemotherapy to prevent recurrence of ALL. (ucsfhealth.org)
  • Patients begin taking them during induction chemotherapy and continue indefinitely. (ucsfhealth.org)
  • The chemotherapy and/or radiation given to patients as part of a stem cell transplant. (bcm.edu)
  • A method of treating patients with repetitive, low doses of chemotherapy drugs over a longer period of time. (bcm.edu)
  • Skeletal Muscle Loss during Neoadjuvant Chemotherapy Is an Independent Risk Factor for Postoperative Infectious Complications in Patients with Advanced Esophageal Cancer. (bioportfolio.com)
  • The purpose of this study is to determine whether docetaxel, cisplatin, and capecitabine (DCX) are effective as the neoadjuvant chemotherapy before esophagectomy in patients with loco-regi. (bioportfolio.com)
  • The purpose of this study is to evaluate the outcomes of neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy followed by minimally invasive esophagectomy on patients with locally. (bioportfolio.com)
  • A CR was achieved in 100% of patients with R/R HCL treated with the chemotherapy-free combination of vemurafenib plus rituximab. (clinicaloptions.com)
  • Prior to the wide use and adaptability to PET scans, most patients underwent consolidative RT or high-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HSCT) after completion of systemic therapy. (medscape.com)
  • Several reports have suggested inferior survival in patients with DLBCL who have residual PET scan positivity at the end of chemotherapy and other studies have shown that patients who have a positive interim PET scan (after 2-4 cycles of therapy) predict higher risk of subsequent relapse. (medscape.com)
  • Further, when PET-positive patients received RT consolidation, no significant difference in outcome was observed between PET-positive and PET-negative patients, suggesting that some patients can avoid undergoing RT when PET is used to guide therapy. (medscape.com)
  • Patients with standard risk receive further consolidation and reinduction chemotherapy. (centerwatch.com)
  • Patients with acute leukemia who initially survive invasive fungal disease must receive chemotherapy or go on to transplant. (haematologica.org)
  • Patients with invasive fungal disease, even though they initially survive, undergo significant changes to their chemotherapy therapy. (haematologica.org)
  • Any change in a chemotherapy protocol (delaying courses, dose reduction, or changing the drugs) may impact on the prognosis of acute leukemia patients.13,14 Despite many data on the mortality rates of invasive fungal diseases in hematology patients, there has been no study which looks at their impact in survivors of the event on the application of the acute leukemia chemotherapy regimen which had been initially planned. (haematologica.org)
  • The objectives of this study were to assess the impact of invasive fungal diseases on the application of chemotherapy regimens in patients with acute leukemia surviving invasive fungal diseases, and the possible impact of these changes on the event-free (EFS) and overall survival (OS). (haematologica.org)
  • All acute leukemia patients aged 60 years or under were housed in laminar-air flow (LAF) rooms during the chemotherapy courses with an expected neutropenia of over ten days. (haematologica.org)
  • All patients had a probable or proven invasive fungal disease, were treated within or according to a given protocol of chemotherapy, survived at least four weeks after the invasive fungal disease diagnosis, and were not transplanted, either because they had no indication of hematopoietic cell transplantation (HCT) or they had no donor. (haematologica.org)
  • The patients without progression after induction chemotherapy received apatinib 250 mg per day until disease progression or unacceptable toxicity occurred. (springer.com)
  • 2002 ). Patients with lower pretreatment circulating VEGF levels were more likely to respond to chemotherapy compared to those with higher levels of VEGF (Salven et al. (springer.com)
  • The survival advantage conferred by adding oxaliplatin to adjuvant chemotherapy with fluorouracil (5-FU) in stage III colon cancer, as previously shown in patients in randomized controlled trials, extends to patients in the general population, including older and minority group patients and those. (ascopost.com)
  • some of the patients had also received consolidation chemotherapy or stem-cell transplants. (medscape.com)
  • PRINCETON, N.J.--( BUSINESS WIRE )-- Bristol-Myers Squibb Company (NYSE:BMY) today announced the U.S. Food and Drug Administration (FDA) has expanded the indication for Sprycel ® (dasatinib) tablets to include the treatment of pediatric patients one year of age and older with newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) in combination with chemotherapy. (businesswire.com)
  • The efficacy of Sprycel tablets in combination with chemotherapy was evaluated in a single cohort of the Phase 2, multicenter, single-arm CA180-372 study, which included 78 pediatric patients with newly diagnosed B-cell precursor Ph+ ALL. (businesswire.com)
  • This randomized phase II / III trial studies how well combination chemotherapy with or without rituximab works in treating younger patients with stage III-IV non-Hodgkin lymphoma or B-cell acute leukemia. (cancer.gov)
  • It is not yet known whether combination chemotherapy together with rituximab is more effective in treating patients with non-Hodgkin lymphoma or B-cell acute leukemia. (cancer.gov)
  • Risk-directed therapy included recommending allogeneic hematopoietic stem cell transplantation (allo-HSCT) for high-risk patients and chemotherapy/autologous-HSCT (auto-HSCT) for low-risk patients. (bloodjournal.org)
  • Among 116 eligible patients, MRD status after the second consolidation rather than induction or first consolidation could discriminate high-risk relapse patients ( P = .001). (bloodjournal.org)
  • disease-free survival [DFS]: 61.7% vs 19.6%, P = .001), whereas chemotherapy/auto-HSCT achieved a low relapse rate (5.3%) and high DFS (94.7%) for low-risk patients. (bloodjournal.org)
  • The results of our study suggest that consolidation RT in patients with advanced-stage HD with initial bulky disease who had postchemotherapy radiologic CR or PR with metabolic CR improved the DFS. (dovepress.com)
  • Giving alisertib alone or with chemotherapy and radiation therapy may be effective in treating patients with rhabdoid tumors. (cancer.gov)
  • This portion of the treatment is less toxic and is usually much easier to tolerate then the induction and consolidation phases.Most patients will receive oral doses of mercaptopuine (6-MP) every evening and weekly oral methetrexate. (caringbridge.org)
  • PURPOSE: This phase II trial is studying how well giving combination chemotherapy works in treating patients with acute promyelocytic leukemia. (ichgcp.net)
  • Patients are evaluated between days 60-67 and proceed to consolidation therapy. (ichgcp.net)
  • Consolidation therapy: Patients receive cytarabine IV continuously on days 1-3, daunorubicin hydrochloride IV on days 1-3, and arsenic trioxide IV over 1-2 hours once daily, 5 days a week, beginning on day 8 and continuing for 6 weeks. (ichgcp.net)
  • It helps to consolidate the gains during induction chemotherapy and may be followed by MAINTENANCE CHEMOTHERAPY. (nih.gov)
  • We aimed to assess whether megatherapy with autologous stem-cell transplantation could increase event-free survival and overall survival compared with maintenance chemotherapy. (nih.gov)
  • 1 year old) were randomly assigned to myeloablative megatherapy (melphalan, etoposide, and carboplatin) with autologous stem-cell transplantation (n=149) or to oral maintenance chemotherapy with cyclophosphamide (n=146). (nih.gov)
  • The role of maintenance chemotherapy in advanced nonsmall cell lung cancer. (naver.com)
  • They were followed by maintenance chemotherapy with cytosine arabinoside and thioguanine 2 monthly. (hku.hk)
  • In this research study, the investigators are combining the use of venetoclax (the investigational drug being studied) with chemotherapy drugs daunorubicin and cytarabine. (clinicaltrials.gov)
  • The purpose of phase 1 part in this study is to determine the maximum tolerated dose (MTD) and/or recommended expansion dose (RED) of ASP2215 concomitant with cytarabine/idarubicin as induction chemotherapy based on the status of the onset of dose-limiting toxicity (DLT) in newly diagnosed Acute Myeloid Leukemia (AML) subjects. (centerwatch.com)
  • Phase 1 part will also evaluate safety and tolerability and characterize the pharmacokinetic (PK) parameters of ASP2215 concomitant with induction and consolidation chemotherapy as well as evaluate the PK parameters of cytarabine concomitant with ASP2215. (centerwatch.com)
  • The drug used in intrathecal chemotherapy is methotrexate or cytarabine. (cancer.ca)
  • The Spanish PETHEMA group designed a protocol for newly diagnosed PML/RAR-positive acute promyelocytic leukemia (APL) in which induction and consolidation followed the original AIDA regimen, except for the omission of cytarabine and etoposide from consolidation. (bloodjournal.org)
  • 3) The additional benefit, if any, provided by cytarabine administered in induction and/or in consolidation remains unclear. (bloodjournal.org)
  • In fact, although randomized trials comparing different chemotherapy induction regimens in APL have not been performed, the inclusion of cytarabine in addition to daunorubicin, with or without other chemotherapy agents (eg, thioguanine, etoposide), does not appear to significantly affect disease outcome, 10 nor does it seem to provide better results than those obtained with high-dose daunorubicin 11-14 or idarubicin alone. (bloodjournal.org)
  • This trial is looking at using liposomal daunorubicin, mitoxantrone, fludarabine and cytarabine to improve chemotherapy for acute myeloid leukaemia. (cancerresearchuk.org)
  • High dose cytarabine (HD Ara-C) is one of the standard treatments that doctors use for consolidation chemotherapy. (cancerresearchuk.org)
  • They think that the combination of fludarabine and cytarabine might work better as consolidation chemotherapy than HD Ara-C for people who have standard risk of their leukaemia coming back. (cancerresearchuk.org)
  • They need CNS prophylaxis in the form of cranial irradiation (less commonly used now), intrathecal (methotrexate, cytarabine, steroids) and high-dose systemic chemotherapy (methotrexate, cytarabine, L-asparaginase). (news-medical.net)
  • In terms of drugs, the key difference between consolidation chemotherapy and induction chemotherapy is that in induction therapy cytarabine and anthracycline are used, while in consolidation only cytarabine is used. (news-medical.net)
  • They may be treated with low intensity chemotherapy usually involving 1 to 2 cycles of cytarabine or 1 to 2 cycles of standard dose cytarabine usually along with daunorubicin or idarubicin. (news-medical.net)
  • This is usually similar to induction, using both ATRA and chemotherapy (daunorubicin, sometimes along with cytarabine). (cancer.org)
  • The injection is a form of chemotherapy called ARAC (Cytarabine). (caringbridge.org)
  • This trial is to assess the efficacy and feasibility of consolidation chemotherapy after neoadjuvant chemoradiotherapy for locally advanced mid or low rectal cancer. (clinicaltrials.gov)
  • Conclusion: Pemetrexed-cisplatin combined with TRT followed by consolidation pemetrexed was not superior to standard chemoradiotherapy for stage III unresectable nonsquamous non-small-cell lung cancer. (elsevier.com)
  • The purpose of the study was to test a null hypothesis that a combined modality treatment of esophageal cancer with neoadjuvant chemotherapy or chemoradiotherapy is equivalent to surgery a. (bioportfolio.com)
  • If the leukemia has spread to the CNS, treatment may include chemotherapy given directly into the spinal fluid (called intrathecal chemotherapy). (cancer.ca)
  • Radiation therapy is sometimes given to the brain and spinal cord along with intrathecal chemotherapy. (cancer.ca)
  • This is called intrathecal chemotherapy. (ucsfhealth.org)
  • CNS therapy is given as intrathecal chemotherapy, where drugs are given directly into the cerebrospinal fluid (CSF) around the spinal cord. (cancer.ca)
  • The same needle can be used to insert medicines to prevent or treat leukemia in the brain or spinal cord (intrathecal chemotherapy). (chop.edu)
  • APL rarely spreads to the brain or spinal cord, so intrathecal chemotherapy is usually not needed. (cancer.org)
  • This process is called intrathecal chemotherapy. (mskcc.org)
  • Chemotherapy, usually with methotrexate, is also given into the spinal fluid (known as intrathecal chemo) for at least 4 doses, each separated by a week. (cancer.org)
  • A targeted therapy drug called a tyrosine kinase inhibitor may be added to the consolidation chemotherapy regimen for people with leukemia cells that have a certain genetic mutation called FLT3. (cancer.ca)
  • The duration of ZARXIO therapy needed to attenuate chemotherapy-induced neutropenia may be dependent on the myelosuppressive potential of the chemotherapy regimen employed. (rxlist.com)
  • The main cause of deaths was relapse in the consolidation chemotherapy group. (bvsalud.org)
  • Studies have shown that stem cell transplants are more effective than chemotherapy in reducing the risk of disease relapse. (news-medical.net)
  • To prevent relapse at this location, chemotherapy must be injected directly into the fluid that bathes the spinal column. (ucsfhealth.org)
  • Treatment designed to help prevent a relapse of a disease following the successful primary treatments (INDUCTION CHEMOTHERAPY and CONSOLIDATION CHEMOTHERAPY) with a long-term low-dose drug therapy. (bioportfolio.com)
  • Even though most of the cancer was killed in the Induction phase, without further chemotherapy Josh would quickly relapse. (caringbridge.org)
  • A bone marrow transplant, also known as a stem cell transplant, may be used as consolidation therapy in people at high risk of relapse or for treating relapse when it occurs. (mayoclinic.org)
  • In addition, it is not yet known whether chemotherapy and radiation therapy are more effective when given with consolidation chemotherapy in treating cervical cancer. (clinicaltrials.gov)
  • 1. Subjects who are not considered to be candidates to complete the consolidation therapy due to medical or psychological reasons. (knowcancer.com)
  • Phase 2 cohort will also evaluate safety and characterize the PK parameters of ASP2215 in combination with induction and consolidation therapy followed by maintenance therapy in newly diagnosed FLT3-mutated AML subjects. (centerwatch.com)
  • Children with low-risk medulloblastoma will all receive a single cycle of consolidation therapy. (mskcc.org)
  • You may be offered a stem cell transplant for consolidation therapy for AML. (cancer.ca)
  • Consolidation (intensification) therapy. (ahealthyme.com)
  • In consolidation phase Imatinib (a tyrosine kinase inhibitor) has also been used as a single agent or part of combination therapy. (news-medical.net)
  • Prolongation of progression-free survival and overall survival have been reported with consolidation therapy after first-line chemotherapy in non-small cell lung cancer, but only a few pharmacoeconomic analyses have been performed. (naver.com)
  • We performed a pharmacoeconomic analysis to assess the cost-effectiveness of consolidation therapy with pemetrexed compared with non-consolidation therapy. (naver.com)
  • We developed a Markov model to evaluate the incremental cost-effectiveness ratio (ICER) of consolidation therapy with pemetrexed compared with non-consolidation therapy based on previous reports. (naver.com)
  • The ICER for consolidation therapy with pemetrexed was about US$ 109,024/life years gained (LYG) (JPY 12.5 million/LYG) and US$ 203,022/quality-adjusted life years (QALY) (JPY 23.3 million/QALY) for all histology. (naver.com)
  • This result indicates that it is difficult to use consolidation therapy as the standard of care in Japan while being covered by general medical insurance. (naver.com)
  • The more intensive the chemotherapy and the closer together the courses of therapy are given, the less chance the leukemia has of returning. (texasoncology.com)
  • Consolidation therapy can be accomplished with multiple courses of chemotherapy or high-dose chemotherapy with autologous or allogeneic stem cell transplantation. (texasoncology.com)
  • Despite the initial choice of consolidation therapy, it is important to determine the availability of a marrow or stem cell donor as soon as possible following the initial diagnosis of AML. (texasoncology.com)
  • The phase III PROCLAIM study evaluated overall survival (OS) of concurrent pemetrexed-cisplatin and thoracic radiation therapy (TRT) followed by consolidation pemetrexed, versus etoposide-cisplatin and TRT followed by nonpemetrexed doublet consolidation therapy. (elsevier.com)
  • In conclusion, despite the significant myelosuppression observed, overall improvement in treatment outcome was not demonstrable with the use of this intensive consolidation therapy. (hku.hk)
  • Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study. (qxmd.com)
  • Consolidation therapy involves intensive chemotherapy given right after recovery from induction. (news-medical.net)
  • Today's treatments for leukemia, lymphoma and myeloma sometimes combine chemotherapy with radiation therapy. (lls.org)
  • High-dose therapy with single autologous transplantation versus chemotherapy for newly diagnosed multiple myeloma: a systematic review and meta-analysis of randomized controlled trials. (springer.com)
  • Also called consolidation or intensification therapy. (nccn.org)
  • Treatment may involve some combination of chemotherapy , radiation therapy , targeted therapy , and bone marrow transplant , in addition to supportive care and palliative care as needed. (wikipedia.org)
  • Treatment for recurrent childhood ALL usually includes giving induction chemotherapy again (called reinduction therapy). (cancer.ca)
  • It is followed by consolidation and maintenance therapy. (cancer.ca)
  • ATRA plus ATO is also being studied as an option for consolidation therapy. (cancer.org)
  • The goal of consolidation therapy is to destroy any remaining leukemia cells. (healthline.com)
  • These are induction therapy, consolidation therapy and symptom control. (macmillan.org.uk)
  • Induction therapy includes chemotherapy, targeted therapies and steroids. (macmillan.org.uk)
  • Consolidation therapy is high-dose treatment and a stem cell transplant. (macmillan.org.uk)
  • What is the role of consolidation therapy in the treatment of primary mediastinal B-cell lymphoma (PMBCL)? (medscape.com)
  • Others may need chemotherapy as part of their consolidation therapy. (mskcc.org)
  • After consolidation therapy, people with high-risk disease may stay on maintenance therapy for a few years to keep the cancer from coming back. (mskcc.org)
  • This therapy is given intermittently and combines ATRA and low-dose chemotherapy. (mskcc.org)
  • The study evaluates the efficacy and tolerability of an intensified induction and consolidation therapy. (centerwatch.com)
  • 1999 ), maintenance therapy, and consolidation chemotherapy (Rossi et al. (springer.com)
  • However, a phase II trial of sorafenib in conjunction with chemotherapy as maintenance therapy in extensive-stage small-cell lung cancer showed that combination therapy has significant toxicity at current dose levels and is associated with disappointing efficacy data (Sharma et al. (springer.com)
  • Chemotherapy, which uses drugs to kill cancer cells, is typically used as an induction therapy for children and adults with acute lymphocytic leukemia. (mayoclinic.org)
  • Targeted therapy may be used during or after chemotherapy. (mayoclinic.org)
  • After the chemotherapy (and maybe radiation therapy), you might get a day or 2 to rest. (ahealthyme.com)
  • If it is not feasible to attempt aggressive therapy, reasonable control of the disease for a short period may be obtained with low dose chemotherapy. (leukaemia.org.au)
  • In the expansion part of Phase 1 part, a maximum of 3 subjects will receive ASP2215 at RED that has been recommended in the dose-evaluation part and the safety will be assessed based on the onset of DLTs during Cycle 1 of the induction and consolidation periods. (centerwatch.com)
  • What are induction and consolidation chemotherapy for AML? (youandaml.com)
  • Dr. Sandra Kurtin, an expert on acute myeloid leukemia ( AML ), describes the induction and consolidation phases of chemotherapy treatment for this disease. (youandaml.com)
  • Except for those with mature-B ALL who receive short-term intensive chemotherapy, treatment for ALL typically consists of two phases of induction and consolidation. (news-medical.net)
  • The closer together induction and consolidation are given, the lesser the chance of leukemia recurrence. (news-medical.net)
  • Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood. (nih.gov)
  • 0.001) but a higher rate of treatment-related mortality (15 percent vs. 2.7 percent, P = 0.005) in the group treated with autologous transplantation than in the intensive-chemotherapy group. (nih.gov)
  • Myeloablative chemotherapy with autologous stem-cell transplantation improves the outcome for children with high-risk neuroblastoma despite the raised risk of treatment-associated death. (nih.gov)
  • A phase III randomized multi-center study designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. (roswellpark.org)
  • About 510 subjects will be randomized in a 1:1 ratio to receive either crenolanib in addition to standard first line treatment of AML (chemotherapy and if eligible, transplantation) (arm A) or midostaurin and standard treatment (arm B). Potentially eligible subjects will be registered and tested for the presence of FLT3 mutation. (roswellpark.org)
  • Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. (ox.ac.uk)
  • Stem cell transplantation is used to intensify the chemotherapies and radiotherapies as it replaces destroyed stem cells. (news-medical.net)
  • The role of stem cell transplantation in APL has to be determined in comparison with that of consolidation chemotherapy . (bvsalud.org)
  • The treatment -related mortalities of the groups were 0% in chemotherapy group and 14.3% in transplantation group. (bvsalud.org)
  • It can be risky due to the high intensity chemotherapy or radiation given prior to stem cell transplantation. (news-medical.net)
  • Very high dose chemotherapy followed by stem cell transplantation can also be used. (lls.org)
  • A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma: intergroupe francais du myeloma. (springer.com)
  • Phase I/II study of tandem high-dose chemotherapy with autologous peripheral blood stem cell transplantation for advanced multiple myeloma. (springer.com)
  • Causes of neutropenia include chemotherapy and bone marrow transplantation. (wikipedia.org)
  • They will be randomized and assigned to undergo TME followed by 8 cycles of adjuvant chemotherapy (control arm) or receive 3 cycles of consolidation chemotherapy before TME, and receive 5 cycles of adjuvant chemotherapy (experimental arm). (beds.ac.uk)
  • In addition, paclitaxel/cisplatin combination chemotherapy was demonstrated to have superior progression-free survival than platinum alone in some phase Ⅱ studies. (clinicaltrials.gov)
  • our study shows that CRT with 5-FU and cisplatin, with or without consolidation chemotherapy, was well tolerated and proved highly encouraging in terms of long-term survival and the preservation of anal function in ASCC. (beds.ac.uk)
  • Around 1980, several small trials demonstrated that adding chemotherapy after RT improved survival. (wikibooks.org)
  • 2002 ). To improve the survival outcome, a number of therapeutic approaches have been tried, such as dose dense chemotherapy (Masutani et al. (springer.com)
  • In the study, Sprycel plus chemotherapy demonstrated a three-year event-free survival benefit. (businesswire.com)
  • This research study is studying the combination of venetoclax and chemotherapy as a possible treatment for acute myelogenous leukemia (AML). (clinicaltrials.gov)
  • Conclusions: The intensified treatment paradigm of XELOX concurrent chemoradiation followed by one cycle of consolidation chemotherapy was well tolerated in our cohort and provided a promising long-term oncologic outcome, which warranted further investigation in a randomize trails. (medworm.com)
  • The goal of consolidation treatment for acute myelogenous leukemia (AML) is to prevent leukemia cells from coming back. (cancer.ca)
  • Chemotherapy is the main consolidation treatment for AML. (cancer.ca)
  • Chemotherapy is treatment with cancer -fighting drugs . (webmd.com)
  • Your doctor may use chemotherapy as your main treatment, or you may have it before you have a stem cell transplant. (webmd.com)
  • The first phase of treatment is called induction chemotherapy . (youandaml.com)
  • Primary central nervous system (CNS) lymphoma treatment options include radiation, chemotherapy, and corticosteroids. (oncolink.org)
  • This treatment involves having chemotherapy through a central venous access device (CVAD). (eviq.org.au)
  • Chemotherapy is the main treatment for nearly all people with acute lymphocytic leukemia (AML). (ahealthyme.com)
  • If the first treatment with chemotherapy doesn't work, your doctor may advise another type of chemotherapy. (ahealthyme.com)
  • If you get chemotherapy, you will likely meet with a hematologist/oncologist before treatment starts. (ahealthyme.com)
  • Treatment for AML carried out in two stages - the initial stage or induction stage to kill the leukemia cells of the bone marrow and the consolidation stage to kill any remaining leukemia cells that may be present in the body. (news-medical.net)
  • Treatment involves receiving regular injections of chemotherapy medication. (news-medical.net)
  • The consolidation phase of treatment lasts several months. (news-medical.net)
  • Potential treatment opinions after first-line chemotherapy for advanced NSCLC: maintenance treatment or early second-line? (naver.com)
  • The following is a general overview of the treatment of the consolidation treatment options for acute myeloid leukemia. (texasoncology.com)
  • We recently proposed that retrograde amnesia does not result from a disruption of the consolidation/reconsolidation processes but rather to the integration of the internal state induced by the amnesic treatment within the initial memory. (frontiersin.org)
  • The length of the consolidation period was thus defined by the time after which the administration of the treatment no longer affected the retention performance. (frontiersin.org)
  • Determining the best treatment option for consolidation is not easy and each approach has its own pros and cons. (news-medical.net)
  • Most people stay in the hospital during treatment because chemotherapy also kills healthy cells, raising your risk for infection and abnormal bleeding. (healthline.com)
  • The second stage of treatment, called "consolidation," is undertaken with the goal to cure the disease. (bio-medicine.org)
  • Addition of rituximab to CHOP-like chemotherapy in first line treatment of primary mediastinal B-cell lymphoma. (medscape.com)
  • 1991 ). The main cause of treatment failure is rapid recurrence and resistance to second-line chemotherapy (Schiller et al. (springer.com)
  • We concluded that MRD status after the second consolidation may be the best timing for treatment choice. (bloodjournal.org)
  • In general, all children with non-Hodgkin lymphoma (NHL) are treated with chemotherapy (chemo), but the exact treatment differs depending on the type and stage of the lymphoma. (cancer.org)
  • Therefore, chemotherapy is an important part of treatment for all children with NHL. (cancer.org)
  • Chemotherapy (chemo) is the main form of treatment for these lymphomas. (cancer.org)
  • Studies are now being done to determine whether adding a monoclonal antibody such as rituximab to chemotherapy will make treatment more effective. (cancer.org)
  • Studies are being done to determine whether adding other drugs to chemotherapy might make treatment more effective. (cancer.org)
  • Treatment for these lymphomas usually consists of chemotherapy with 4 or more drugs given for about 3 to 6 months. (cancer.org)
  • He received a week off from chemotherapy before he started his next phase of treatment so he could increase his blood counts and strengthen his immune system. (caringbridge.org)
  • On Thursday, July 12 he started the Consolidation phase of his treatment. (caringbridge.org)
  • He will get the standard chemotherapy that is treated the same way throughout the country, plus additonal treatment and drugs that are part of this study to further the research to lower the risk of the cancer coming back. (caringbridge.org)
  • In this type of treatment, chemotherapy drugs are often injected directly into the fluid that covers the spinal cord. (mayoclinic.org)
  • Chemotherapy is the main form of treatment for AML. (leukaemia.org.au)
  • The investigators are looking to determine the highest dose of venetoclax that can be given safely in combination with these chemotherapy drugs. (clinicaltrials.gov)
  • A device surgically implanted beneath the scalp that is used to deliver chemotherapy drugs directly into the cerebrospinal fluid (CSF) around the brain and spinal cord. (cancer.ca)
  • Some medicines help chemotherapy drugs work better. (webmd.com)
  • Corticosteroids ( steroids ) like dexamethasone and prednisone help chemotherapy drugs kill more myeloma cells. (webmd.com)
  • Chemotherapy is the use of potent drugs or chemicals, often in combinations or intervals, to kill or damage cancer cells in the body. (lls.org)
  • Chemotherapy drugs are often called anticancer agents. (lls.org)
  • All chemotherapy drugs interfere with cancer cells' ability to grow or multiply. (lls.org)
  • That's why it's essential that the disease be accurately diagnosed: Certain chemotherapy drugs are used only for certain disease cell types. (lls.org)
  • Both new chemotherapy drugs and new ways to attack cancer cells continue to emerge as research progresses. (lls.org)
  • Many chemotherapy drugs attack cancer cells by interacting with the cancer cell's DNA or RNA (genetic makeup). (lls.org)
  • Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (swedish.org)
  • Some doctors believe it may be related to exposure to certain chemicals, radiation , and even drugs used for chemotherapy . (healthline.com)
  • Its intensity can be reduced by steroids, chemotherapy, proteasome inhibitors, immunomodulatory drugs such as thalidomide or lenalidomide, and stem cell transplants. (newsmaker.com.au)
  • This typically means getting a combination of chemotherapy drugs in the hospital for about a week. (seattlecca.org)
  • Chemotherapy is given in 3 phases (induction, consolidation, and maintenance) using many chemo drugs. (cancer.org)
  • It is given as 3 phases of chemotherapy (induction, consolidation, and maintenance) using many drugs, and it lasts for about 2 years. (cancer.org)
  • Chemotherapy drugs can also be used in the consolidation and maintenance phases. (mayoclinic.org)
  • Chemotherapy is usually given as a combination of drugs, usually given over a period of a week or so. (leukaemia.org.au)
  • Bacillus cereus sepsis and subarachnoid hemorrhage following consolidation chemotherapy for acute myelogenous leukemia]. (nih.gov)
  • Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute lymphoblastic leukemia. (haematologica.org)
  • BACKGROUND AND OBJECTIVES: To evaluate the impact of early and delayed consolidation chemotherapy on the outcome of children with acute lymphoblastic leukemia (ALL) stratified according to risk groups. (haematologica.org)
  • If there are still leukemia cells in your bone marrow, you may have a second course of chemotherapy. (ahealthyme.com)
  • The first two phases use intensive chemotherapy medications designed to kill the leukemia cells that grow quickly. (ucsfhealth.org)
  • Find out more about chemotherapy for childhood leukemia . (cancer.ca)
  • A bone marrow transplant begins with high doses of chemotherapy or radiation to destroy any leukemia-producing bone marrow. (mayoclinic.org)
  • Among all ovarian cancers, the worst prognosis is seen in ovarian clear cell carcinomas (OCCC) which typically don't respond to chemotherapy. (genengnews.com)
  • Depending on when the participant join the study, the participant may participate in part 1 (induction with venetoclax escalation), part 2 (consolidation with venetoclax escalation), or part 3 (an expansion cohort utilizing the maximum tolerated doses identified in parts 1 and 2). (clinicaltrials.gov)
  • After chemotherapy, your doctor may still want you to take low doses of these to keep new tumors from growing. (webmd.com)
  • You may get higher doses of chemotherapy medicines for several days. (ahealthyme.com)
  • Chemotherapy for AML is typically given in high doses. (ahealthyme.com)
  • Twenty-one (67.7%) received consolidation chemotherapy with the same doses of 5-fluorouracil and cisplatin, repeated every 4 weeks for maximum 4 cycles. (beds.ac.uk)
  • This differs from most standard chemotherapy treatments which are given at high doses for short periods of time. (bcm.edu)
  • A stem cell transplant that includes lower doses of chemotherapy and/or radiation than is standard. (bcm.edu)
  • A higher percentage of radical resection is reported in studies using neoadjuvant chemotherapy followed by surgery versus surgery alone for esophageal cancer. (bioportfolio.com)
  • Organ Preservation in Locally Advanced Rectal Cancer by Radiochemotherapy Followed by Consolidation Chemotherapy. (clinicaltrials.gov)
  • Another option may be very high-dose chemotherapy along with a stem cell transplant. (ahealthyme.com)
  • After PBSC harvesting, high-dose chemotherapy of melphalan with auto-PBSCT was performed. (springer.com)
  • 2000 ), high-dose chemotherapy (Leyvraz et al. (springer.com)
  • First, the bone marrow with cancer is destroyed with high-dose chemotherapy. (ahealthyme.com)
  • This is done before you get the high-dose chemotherapy. (ahealthyme.com)
  • Chemotherapy agents used during consolidation include the same agents used during induction, as well as Ara-C, etoposide, methotrexate and 6-mercaptopurine. (ucsfhealth.org)
  • These oral chemotherapy pills - typically methotrexate and 6-mercaptopurine - are usually well-tolerated with only minimal side effects. (ucsfhealth.org)
  • Shorter and less intensive treatments, such as the chemotherapy combinations called CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) and COMP (cyclophosphamide, vincristine, methotrexate, and prednisone) have also been used. (cancer.org)
  • Allogeneic stem cell transplant involves the transfer of stem cells from a healthy donor to the patient's body after intensive radiation or chemotherapy. (news-medical.net)
  • This type of stem cell transplant is most commonly used in situations where the patient has underlying conditions that might make the chemotherapy/radiation excessively toxic to them. (bcm.edu)
  • A stem cell transplant may also be used when ALL comes back after a second course of chemotherapy. (cancer.ca)
  • For AML with "good-risk" chromosome changes, additional chemotherapy or an autologous transplant is usually recommended. (bio-medicine.org)
  • Transplant may be done instead of consolidation chemo. (ahealthyme.com)
  • Some people with higher-risk disease may be given chemotherapy directly into the fluid that surrounds the spinal cord and brain. (mskcc.org)
  • Further trials with a larger patient population are warranted in order to evaluate the potential role of consolidation chemotherapy. (beds.ac.uk)
  • 3-9 As shown in a randomized study, 9 simultaneous combination is more effective than sequential administration of ATRA and chemotherapy. (bloodjournal.org)
  • Children with APL get a non-chemotherapy drug similar to vitamin A called all-trans retinoic acid (ATRA) . (cancer.org)
  • Previously untreated Stage III or IV classical Hodgkin lymphoma (cHL), in combination with chemotherapy. (drugs.com)
  • Chemotherapy during this phase is given intravenously or orally in combination. (news-medical.net)
  • Giving more than one drug (combination chemotherapy) may kill more cancer cells. (ichgcp.net)
  • After the stem cells have been collected, they will be stored and then given again after the consolidation phase, to help the child's blood-forming system to re-establish itself. (mskcc.org)
  • Such a notion was close to the idea previously developed by Müller and Pilzecker (1900) whose work on retroactive interference led them to suggest that new memories are fragile, requiring time to undergo a consolidation phase before being fixed. (frontiersin.org)
  • He had about 6 or 7 hospital stays throughout this Consolidation phase. (caringbridge.org)
  • These data indicate that a significant reduction in toxicity might be obtained in APL using a less intensive consolidation without apparently compromising the antileukemic effect. (bloodjournal.org)
  • The intent of metronomic chemotherapy is to decrease toxicity caused by the chemotherapy. (bcm.edu)
  • After recovery, intensification with natural product chemotherapy will be administered, consisting of four cycles of paclitaxel given as a 24-hour infusion followed by four cycles of single agent doxorubicin. (knowcancer.com)
  • The purpose of this study is to determine the efficacy and safety of consolidation chemotherapy with paclitaxel plus cisplatin (2 cycles per 3 weeks) following radical hysterectomy and adjuvant chemoradiation (2 cycles per 4 weeks) for high risk early stage cervical cancer. (clinicaltrials.gov)
  • Chemotherapy uses anticancer medicines to kill cancer cells. (ahealthyme.com)
  • Chemotherapy medicines are designed to attack and kill cells that divide quickly, including cancer cells. (ahealthyme.com)
  • Neoadjuvant chemotherapy in local-regionally advanced nasopharyngeal carcinoma: A National Cancer Database analysis. (bioportfolio.com)
  • Chemotherapy refers to medicines that help fight cancer. (chop.edu)
  • Chemotherapy for other forms of cancer. (encyclopedia.com)
  • To evaluate the efficacy of maintenance apatinib after chemotherapy for extensive-stage (ED) small-cell lung cancer (SCLC). (springer.com)