Consolidation Chemotherapy: Drug treatment designed to further diminish the disease toward complete remission following INDUCTION CHEMOTHERAPY. It helps to consolidate the gains during induction chemotherapy and may be followed by MAINTENANCE CHEMOTHERAPY.Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Cytarabine: A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)Daunorubicin: A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.Remission Induction: Therapeutic act or process that initiates a response to a complete or partial remission level.Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.Idarubicin: An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA.Amsacrine: An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Etoposide: A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.Mitoxantrone: An anthracenedione-derived antineoplastic agent.Leukemia, Myeloid: Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Chemotherapy, Adjuvant: Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Transplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Cyclophosphamide: Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Precursor Cell Lymphoblastic Leukemia-Lymphoma: A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.Leukemia, Promyelocytic, Acute: An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Neutropenia: A decrease in the number of NEUTROPHILS found in the blood.Memory: Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Acute Disease: Disease having a short and relatively severe course.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Cisplatin: An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Doxorubicin: Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Retention (Psychology): The persistence to perform a learned behavior (facts or experiences) after an interval has elapsed in which there has been no performance or practice of the behavior.Fear: The affective response to an actual current external danger which subsides with the elimination of the threatening condition.Neoadjuvant Therapy: Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Induction Chemotherapy: Initial drug treatment designed to bring about REMISSION INDUCTION. It is typically a short-term and high-dose drug treatment that is followed by CONSOLIDATION CHEMOTHERAPY and then MAINTENANCE CHEMOTHERAPY.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Breast Neoplasms: Tumors or cancer of the human BREAST.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Conditioning, Classical: Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.Avoidance Learning: A response to a cue that is instrumental in avoiding a noxious experience.Memory, Long-Term: Remembrance of information from 3 or more years previously.Lung Neoplasms: Tumors or cancer of the LUNG.Anisomycin: An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.Sleep: A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.Learning: Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge.Carboplatin: An organoplatinum compound that possesses antineoplastic activity.Conditioning (Psychology): A general term referring to the learning of some particular response.Amygdala: Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Vinblastine: Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Bleomycin: A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.Association Learning: The principle that items experienced together enter into a connection, so that one tends to reinstate the other.Freezing Reaction, Cataleptic: An induced response to threatening stimuli characterized by the cessation of body movements, except for those that are involved with BREATHING, and the maintenance of an immobile POSTURE.Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Ifosfamide: Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.Taxoids: A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.Mental Recall: The process whereby a representation of past experience is elicited.Anthracyclines: Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.Electroshock: Induction of a stress reaction in experimental subjects by means of an electrical shock; applies to either convulsive or non-convulsive states.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Hippocampus: A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.Salvage Therapy: A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.Osteogenesis, Distraction: Bone lengthening by gradual mechanical distraction. An external fixation device produces the distraction across the bone plate. The technique was originally applied to long bones but in recent years the method has been adapted for use with mandibular implants in maxillofacial surgery.Health Facility Merger: The combining of administrative and organizational resources of two or more health care facilities.Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Melphalan: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.Antineoplastic Agents, Alkylating: A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)DeoxycytidineOrganoplatinum Compounds: Organic compounds which contain platinum as an integral part of the molecule.Neoplasm, Residual: Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Extinction, Psychological: The procedure of presenting the conditioned stimulus without REINFORCEMENT to an organism previously conditioned. It refers also to the diminution of a conditioned response resulting from this procedure.Carcinoma, Non-Small-Cell Lung: A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.Radiotherapy, Adjuvant: Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.Thioguanine: An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.Maze Learning: Learning the correct route through a maze to obtain reinforcement. It is used for human or animal populations. (Thesaurus of Psychological Index Terms, 6th ed)Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Recurrence: The return of a sign, symptom, or disease after a remission.Chemotherapy, Cancer, Regional Perfusion: Neoplasm drug therapy involving an extracorporeal circuit with temporary exclusion of the tumor-bearing area from the general circulation during which high concentrations of the drug are perfused to the isolated part.Hodgkin Disease: A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.Wakefulness: A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Carmustine: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)Antibiotics, Antineoplastic: Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Asparaginase: A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 188.8.131.52.Vindesine: Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Antineoplastic Agents, Phytogenic: Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.Maintenance Chemotherapy: Treatment designed to help prevent a relapse of a disease following the successful primary treatments (INDUCTION CHEMOTHERAPY and CONSOLIDATION CHEMOTHERAPY) with a long-term low-dose drug therapy.Radiotherapy: The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.Granulocyte Colony-Stimulating Factor: A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.Neuronal Plasticity: The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.Testicular Neoplasms: Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.Protein Synthesis Inhibitors: Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.Dacarbazine: An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)Drug Therapy: The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.Vomiting: The forcible expulsion of the contents of the STOMACH through the MOUTH.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.6-Mercaptopurine: An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.Recognition (Psychology): The knowledge or perception that someone or something present has been previously encountered.Motor Skills: Performance of complex motor acts.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Thiotepa: A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Antibodies, Monoclonal, Murine-Derived: Antibodies obtained from a single clone of cells grown in mice or rats.Infusions, Intravenous: The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.Amnesia: Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)Brain Neoplasms: Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.Long-Term Potentiation: A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.Altretamine: A hexamethyl-2,4,6-triamine derivative of 1,3,5-triazine.Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.Sleep Stages: Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.Neoplasms, Germ Cell and Embryonal: Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.Actuarial Analysis: The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.Behavior, Animal: The observable response an animal makes to any situation.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Lomustine: An alkylating agent of value against both hematologic malignancies and solid tumors.Spatial Behavior: Reactions of an individual or groups of individuals with relation to the immediate surrounding area including the animate or inanimate objects within that area.Camptothecin: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Cranial Irradiation: The exposure of the head to roentgen rays or other forms of radioactivity for therapeutic or preventive purposes.Platinum Compounds: Inorganic compounds which contain platinum as the central atom.Radiotherapy Dosage: The total amount of radiation absorbed by tissues as a result of radiotherapy.Infusions, Intra-Arterial: Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease.Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)LeukopeniaAntiemetics: Drugs used to prevent NAUSEA or VOMITING.Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.Medical Oncology: A subspecialty of internal medicine concerned with the study of neoplasms.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Memory Disorders: Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.Chemoradiotherapy: Treatment that combines chemotherapy with radiotherapy.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Dreams: A series of thoughts, images, or emotions occurring during sleep which are dissociated from the usual stream of consciousness of the waking state.Liver Neoplasms: Tumors or cancer of the LIVER.Peritoneal Neoplasms: Tumors or cancer of the PERITONEUM.Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Stomach Neoplasms: Tumors or cancer of the STOMACH.Multiple Myeloma: A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.Tegafur: Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms.Palliative Care: Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)Radiography, Thoracic: X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Thrombocytopenia: A subnormal level of BLOOD PLATELETS.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Exploratory Behavior: The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity.Vincristine: An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)Germinoma: A malignant neoplasm of the germinal tissue of the GONADS; MEDIASTINUM; or pineal region. Germinomas are uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular eosinophilic-staining cytoplasm. (Stedman, 265th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1642-3)Cell Line, Tumor: A cell line derived from cultured tumor cells.Antitrust Laws: Those federal and state laws, and their enforcement, that protect trade and commerce from unlawful restraints and monopolies or unfair business practices.Sleep Deprivation: The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.Sleep, REM: A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Central Nervous System Neoplasms: Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.Memory, Episodic: Type of declarative memory, consisting of personal memory in contrast to general knowledge.Mediastinal Neoplasms: Tumors or cancer of the MEDIASTINUM.Carcinoma, Squamous Cell: A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)Lymphoma, Large B-Cell, Diffuse: Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.Dexamethasone: An anti-inflammatory 9-fluoro-glucocorticoid.Autografts: Transplant comprised of an individual's own tissue, transferred from one part of the body to another.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Infusions, Parenteral: The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Rats, Long-Evans: An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Amnesia, Retrograde: Loss of the ability to recall information that had been previously encoded in memory prior to a specified or approximate point in time. This process may be organic or psychogenic in origin. Organic forms may be associated with CRANIOCEREBRAL TRAUMA; CEREBROVASCULAR ACCIDENTS; SEIZURES; DEMENTIA; and a wide variety of other conditions that impair cerebral function. (From Adams et al., Principles of Neurology, 6th ed, pp426-9)Bridged Compounds: Cyclic hydrocarbons that contain multiple rings and share one or more atoms.Age Factors: Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.Peripheral Blood Stem Cell Transplantation: Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.Random Allocation: A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.Lymphoma, Follicular: Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.Hyperthermia, Induced: Abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs.Radioimmunotherapy: Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.Microinjections: The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes.Platinum: Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Discrimination Learning: Learning that is manifested in the ability to respond differentially to various stimuli.Head and Neck Neoplasms: Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)Bone Lengthening: Increase in the longest dimension of a bone to correct anatomical deficiencies, congenital, traumatic, or as a result of disease. The lengthening is not restricted to long bones. The usual surgical methods are internal fixation and distraction.American Hospital Association: A professional society in the United States whose membership is composed of hospitals.Economic Competition: The effort of two or more parties to secure the business of a third party by offering, usually under fair or equitable rules of business practice, the most favorable terms.Drug Evaluation: Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.Clinical Trials, Phase III as Topic: Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Clinical Trials, Phase II as Topic: Works about studies that are usually controlled to assess the effectiveness and dosage (if appropriate) of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques. These studies are performed on several hundred volunteers, including a limited number of patients with the target disease or disorder, and last about two years. This concept includes phase II studies conducted in both the U.S. and in other countries.
Treatment of acute promyelocytic leukemia for older patients. (1/34)Acute promyelocytic leukemia (APL) represents a remarkable disease in which leukemogenesis is driven by the PML-RARalpha oncogene and for which targeted treatment with all-trans retinoic acid (ATRA)-based therapy allows substantial chance of cure. APL is seen in a small subset of older patients, with age representing one of the most important prognostic factors for outcome of treatment. Unlike other acute leukemias, the inferior outcomes for APL in older patients relates less to changes in disease biology and more to the increased toxicity of ATRA and the chemotherapy combination regimens used to induce hematologic and molecular responses. Risk-adapted strategies that use less-toxic agents, such as arsenic trioxide, allow treatment of older patients, with greater efficiency and better chances of cure. (+info)
High-dose chemotherapy consolidation for chemosensitive advanced soft tissue sarcoma patients: an open-label, randomized controlled trial. (2/34)(+info)
Results of the APML3 trial incorporating all-trans-retinoic acid and idarubicin in both induction and consolidation as initial therapy for patients with acute promyelocytic leukemia. (3/34)(+info)
Identifying clinical improvement in consolidation single-arm phase 2 trials in patients with ovarian cancer in second or greater clinical remission. (4/34)(+info)
Curing all patients with acute promyelocytic leukemia: are we there yet? (5/34)(+info)
Updated survival and outcomes for older adults with inoperable stage III non-small-cell lung cancer treated with cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel: analysis of a phase III trial from the Hoosier Oncology Group (HOG) and US Oncology. (6/34)(+info)
Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI. (7/34)(+info)
Predictors of prolonged survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma. (8/34)(+info)
Consolidation treatment often entails a repetition of induction chemotherapy or the intensification chemotherapy with ... Chemotherapy, radiation therapy, targeted therapy, bone marrow transplant, supportive care. Prognosis. Five-year survival ... Consolidation therapy or intensification therapy to eliminate any remaining leukemia cells. There are many different approaches ... Such combination chemotherapy usually offers the benefits of early remission and a lower risk of disease resistance. ...
Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is ... Chemotherapy. A woman being treated with docetaxel chemotherapy for breast cancer. Cold mittens and wine coolers are placed on ... The term chemotherapy. The word chemotherapy without a modifier usually refers to cancer treatment, but its historical ... Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall ...
... patients with acute myeloid leukemia receiving induction or consolidation chemotherapy; patients with cancer undergoing bone ... This includes when it occurs following chemotherapy, radiation poisoning, HIV/AIDS, or is of unknown cause. It may also be used ... Causes of neutropenia include chemotherapy and bone marrow transplantation. Filgrastim is also used to increase the number of ... and testing a product under the brand name Nupen which can deliver filgrastim through the skin to improve post-chemotherapy ...
Acute biphenotypic leukaemia
Researchers also found some new chemotherapy method for specific cases. For example, The chemotherapy for ALL and gemtuzuab ... If the patients enter fully remission, the consolidation with stem cell transplantation is highly recommended. The prognosis ... Beside chemotherapy, we should develop new method such as gene drug for BAL therapy. Matutes, E; Morilla R (1997). "Definition ... BAL is hard to treat, usually the chemotherapy is chosen according to the morphology of the blast (ALL or AML). The stem cell ...
Acute lymphoblastic leukemia
Consolidation/intensification Use high doses of chemotherapy to further reduce tumor burden Typical protocols use the following ... ChemotherapyEdit. Chemotherapy is the initial treatment of choice, and most ALL patients receive a combination of medications. ... In general, cytotoxic chemotherapy for ALL combines multiple antileukemic drugs tailored to each patient. Chemotherapy for ALL ... Chemotherapy, stem cell transplantation, radiation therapy, targeted therapy. Prognosis. Children: 90% five-year survival ...
Mantle cell lymphoma
Alternate chemotherapy is sometimes used at first relapse. For frontline treatment, CHOP with rituximab is the most common ... The phases of treatment are generally: frontline, following diagnosis, consolidation, after frontline response (to prolong ... A stronger chemotherapy with greater side effects (mostly hematologic) is HyperCVAD, often given as in-patient, with rituximab ... MCL cells may also be resistant to drug-induced apoptosis, making them harder to cure with chemotherapy or radiation. Cells ...
... two or more cycles of a platinum-based chemotherapy were randomly assigned to receive durvalumab or a placebo as consolidation ... or metastatic urothelial carcinoma who either have disease progression during or following platinum-containing chemotherapy or ... have disease progression within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy. ...
Consolidation treatment often entails a repetition of induction chemotherapy or the intensification chemotherapy with ... Standard treatments involve chemotherapy and radiotherapy. The survival rates vary by age: 85% in children and 50% in adults. ... Such combination chemotherapy usually offers the benefits of early remission and a lower risk of disease resistance. ... Consolidation therapy or intensification therapy to eliminate any remaining leukemia cells. There are many different approaches ...
Induction with chemotherapy (Daunorubicin + Cytarabine), followed by consolidation chemotherapy (High dose cytarabine). Stem ... Intensive chemotherapy phase for initial 6 months and maintenance chemotherapy for 2 years. Prophylactic cranial and stem cell ... Treatment options include radiation, chemotherapy, and surgery.. Stomach cancer. Treatment options include chemotherapy, ... Chemotherapy with ABVD or BEACOPP regimen and Involved field radiation therapy (IFRT).. Non-Hodgkin lymphoma (NHL). Chemo- ...
... as consolidation of the remission status obtained following surgery and standard platinum and taxane first line chemotherapy. ... In spite of initially successful treatment with surgery and chemotherapy, which forces back the tumour "completely", i.e. into ... Nine hundred women in whom the ovarian tumour was removed by surgery and standard chemotherapy with paclitaxel and carboplatin ... Immunological consolidation of ovarian carcinoma recurrences with monoclonal anti-idiotype antibody ACA125: immune responses ...
... chemotherapy), a chemotherapy regimen Institute for Learning, a defunct UK body intended to promote teaching Indian Federation ... advocated consolidation of the British Empire Intact forest landscape Integrated Facility for Linux, an IBM mainframe processor ...
Acute lymphoblastic leukemia
... and continue it during the consolidation/intensification period. Adult chemotherapy regimens mimic those of childhood ALL; ... In general, cytotoxic chemotherapy for ALL combines multiple antileukemic drugs tailored to each patient. Chemotherapy for ALL ... Chemotherapy is the initial treatment of choice, and most ALL patients receive a combination of medications. There are no ... As the chemotherapy regimens can be intensive and protracted, many patients have an intravenous catheter inserted into a large ...
Plasma cell leukemia
Two other studies that included bortezomib in their chemotherapy regimens likewise found that the addition of autologous stem- ... drug regimen such as borezomib-lenalidomide-dexamethasone followed by autologous stem-cell transplantion and consolidation/ ... In one study, patients receiving intensive chemotherapy plus autologous stem-cell transplantation had a median survival of 34 ... months while those receiving chemotherapy alone had a median survival of 11 months. ...
Acute myeloid leukemia
... known as consolidation chemotherapy. For people at high risk of relapse (e.g. those with high-risk cytogenetics, underlying MDS ... The risk is highest about three to five years after chemotherapy. Other chemotherapy agents, specifically epipodophyllotoxins ... induction chemotherapy may not be offered to the very elderly, and the options may include less intense chemotherapy or ... followed by chemotherapy and ATRA plus chemotherapy and the role of maintenance therapy in newly diagnosed acute promyelocytic ...
List of therapies
... chrysotherapy cobalt therapy cold compression therapy combination therapy consolidation therapy contrast bath therapy ... brachytherapy cardiac resynchronization therapy cell therapy cytotherapy cell transfer therapy chelation therapy chemotherapy ...
Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is ... Maintenance chemotherapy is a repeated low-dose treatment to prolong remission. Salvage chemotherapy or palliative chemotherapy ... Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall ... Chemotherapy may be given with a curative intent or it may aim to prolong life or to palliate symptoms. Induction chemotherapy ...
... in combination with chemotherapy. The drug is approved for use with a companion diagnostic, the LeukoStrat CDx FLT3 Mutation ... high-dose C consolidation (consol), and as maintenance (maint) therapy in newly diagnosed acute myeloid leukemia (AML) patients ... to significantly prolong survival of FLT3-mutated AML patients when combined with conventional induction and consolidation ...
ADE is a chemotherapy regimen most often used as an induction or consolidation regimen in acute myelogenous leukemia, ... Fludarabine and cytosine are less effective than standard ADE chemotherapy in high-risk acute myeloid leukemia, and addition of ... regimen or who are relapsed after the standard chemotherapy. ADE regimen consists of three drugs: Ara-C (cytarabine) - an ...
Cytarabine plus idarubicin or daunorubicin as induction and consolidation therapy for previously untreated adult patients with ... "7+3" in the context of chemotherapy is an acronym for a chemotherapy regimen that is most often used today (as of 2014) as ... which is better treated with ATRA and/or arsenic trioxide and requires less chemotherapy (if requires it at all, which is not ... always the case). The name "7+3" comes from the duration of chemotherapy course, which consists of 7 days of standard-dose ...
Sequential high-dose chemotherapy
It is mostly used as consolidation therapy for relapsed or refractory lymphomas and relapsed or refractory Hodgkin disease, ... Sequential high-dose chemotherapy is a chemotherapy regimen consisting of several (2 to 4) sequential monochemotherapies with ... The idea behind this approach is that when using single-agent chemotherapy, the doctor can easily escalate the dose of the drug ... Oyan B, Koc Y, Ozdemir E, Kars A, Turker A, Tekuzman G, Kansu E (2006). "High dose sequential chemotherapy and autologous stem ...
Those can be radiation therapy of the chest , exposure to medications used during chemo-therapy, the inhalation of debris (ie ... the basis of causation as well as its manifestation since pneumonia can be described as pneumonitis combined with consolidation ...
Treatment with chemotherapy has been used with some success, particularly using lomustine, prednisone, doxorubicin, and ... sometimes leading to lung lobe consolidation and pleural effusion. Signs and symptoms include cough, loss of appetite, weight ...
High-dose chemotherapy and bone marrow transplant
... as Consolidation After CAF in High-Risk Primary Breast Cancer Involving Ten or More Axillary Lymph Nodes (LN): Preliminary ... The high-dose chemotherapy resulted in a significantly low relapse rate, and high-dose chemotherapy was associated with ... High-dose chemotherapy and bone marrow transplant (HDC/BMT), also high-dose chemotherapy with autologous bone marrow transplant ... 2003). "Conventional Adjuvant Chemotherapy with or without High-Dose Chemotherapy and Autologous Stem-Cell Transplantation in ...
Index of oncology articles
... chemotherapy - chemotherapy-induced peripheral neuropathy - chest x-ray - chiasma - child-life worker - chitin - chlorambucil ... consolidation therapy - contiguous lymphoma - continent reservoir - contingency management - continuous hyperthermic peritoneal ... high-dose chemotherapy - high-dose-rate remote brachytherapy - high-dose-rate remote radiation therapy - high-energy photon ... systemic chemotherapy - systemic disease - systemic lupus erythematosus - systemic therapy T cell - T-3 - T-cell depletion - T- ...
Ostra białaczka szpikowa, wolna encyklopedia
A randomized comparison of all transretinoic acid (ATRA) followed by chemotherapy and ATRA plus chemotherapy and the role of ... Core-binding factor acute myeloid leukemia: can we improve on HiDAC consolidation?. „Hematology Am Soc Hematol Educ Program". ... Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B. „N Engl J Med". 331 ( ... A tribute to Sidney Farber-- the father of modern chemotherapy. „Br J Haematol". 134 (1), s. 20-6, 2006. DOI: 10.1111/j.1365- ...
Acute myeloid leukemia (AML) Induction with chemotherapy (Daunorubicin + Cytarabine) followed by consolidation chemotherapy ( ... Intensive chemotherapy phase for initial 6 months and maintenance chemotherapy for 2 years. Prophylactic cranial and stem cell ... surgery and chemotherapy. Endometrial cancer Treatment options include surgery, radiation and chemotherapy. Ovary cancer ... chemotherapy and targeted therapy (EGFR inhibitors). Brain cancer Treatment options include surgery, radiation, chemotherapy ...
No signs and symptoms of lobar consolidation, meaning that the infection is restricted to small areas, rather than involving a ... Journal of Chemotherapy. 19 (Suppl 1): 17-23. PMID 18073166. [permanent dead link] Diseases Database Causes of atypical ... In addition, this form of pneumonia is atypical in presentation with only moderate amounts of sputum, no consolidation, only ... a dry irritating cough followed later by a productive cough with radiographs showing consolidation), there are in general few ...
... , or R-HD-AraC ((R)ituximab plus (H)igh (D)ose (A)ra-(C)) is a chemotherapy regimen that is used, alternating with R-Maxi ... HDAC is also used as a consolidation regimen in acute myeloid leukemia after initial 7+3 induction. HDAC also can be used as ...
Clofarabine plus Low-Dose Cytarabine for the Treatment of Patients with Higher-Risk Myelodysplastic Syndrome (MDS) who have...
The goal of this clinical research study is to learn if clofarabine when given in combination with cytarabine can help to control myelodysplastic syndrome (MDS) after the disease could not be controlled with standard therapy. The safety of this treatment will also be studied. Clofarabine is designed to interfere with the growth and development of cancer cells. Cytarabine is designed to insert itself into DNA (the genetic material of cells) of cancer cells and stop the DNA from repairing itself.
Define consolidation chemotherapy. consolidation chemotherapy synonyms, consolidation chemotherapy pronunciation, consolidation chemotherapy translation, English dictionary definition of consolidation chemotherapy. n. 1. The treatment of cancer using specific chemical agents or drugs that are selectively destructive to malignant cells and tissues. 2. The treatment of...
Worldwide Hyperconverged Integrated System Market: Steady Need for Data Center Consolidation to Give Impetus, Finds TMR
Key players in the global hyperconverged integrated systems market include Nutanix, Pivot3, Hewlett Packard Enterprise, Scale Computing, VMware, Inc.
Richard W. Joseph, MD, notes that current treatment guidelines for melanoma recommend anti-PD-1 agents as front line therapy and discusses payer coverage for first-line use of these agents.
Introduction to consolidation concept - The odometer test -Compressibility characteristics - The e-log10бv carve and casagrandepreconsoldation pressure -Teraghi theory for 1-D consolidation - Degree of consolidation - Consolidation settlement and secondary compression - coefficient of consolidation by Taylo and Casagrande method - ...
This morning began a whole new phase of this adventure: consolidation chemotherapy, on an outpatient basis (yay!). We arrived dutifully at 8:15 for our 8:30 appointment. A little before 9:00 a nurse came and got me and took me to the room where they draw blood samples, then led me back to the waiting area. Some undetermined amount of time later-felt like forever, was probably something like 15 or 20 minutes-another nurse came and ushered me into what I think they call the Infusion Room-a large, open room with hardwood floors (!) and 16 big soft leather reclining chairs. She sat me down, and very quickly realized we hadnt received even rudimentary patient education in what was about to happen; so, patiently, she described the process, explained the potential side-effects (ugh), etc., etc. She gave me an anti-nausea drug, then, at about 10:30, finally started the chemo going. Anna sat in the next chair with her laptop, working hard on a major presentation in between calls to our nutritionist and ...
A process of formation consolidation is provided wherein the formation is heated and a substance which acts as a bonding agent when heated is then flowed into the formation. To insure a clean bonding surface, in situ combustion may be initiated in the area to be consolidated prior to injection of the bonding substance. Heat may be supplied to the formation after injection of the bonding substance.
The consolidation with 2.4 cm cavitation is also seen in approximately one third of patients with pulmonary NTM. (2,3,4) Also seen on the inferior aspect of the
The success of data center consolidation initiatives will be determined more by culture and management issues than technology, according to federal managers and industry experts speaking at a recent conference on data center optimization.
Trebananib With or Without Low-Dose Cytarabine in Treating Patients With Acute Myeloid Leukemia - Full Text View -...
PRIMARY OBJECTIVES:. I. To evaluate the safety, tolerability, and pharmacokinetic (PK) and pharmacodynamic (PD) profile of AMG 386 (trebananib) when administered alone and in combination with low-dose cytarabine in adult patients with: untreated AML considered ineligible for standard induction chemotherapy; refractory and/or relapsed AML following at least one cycle of prior therapy who are not currently eligible for stem cell transplantation.. SECONDARY OBJECTIVES:. I. To evaluate clinical responses in AML patients following AMG 386 therapy alone or in combination with low-dose cytarabine therapy.. II. To characterize the biological changes occurring in AML patients treated with AMG 386 alone or in combination with low-dose cytarabine, specifically: alteration in angiopoietin (Ang)1, Ang2, Tie2, vascular endothelial growth factor (VEGF), and VEGF receptor (VEGFR) expression; changes in bone marrow vascularization and hypoxia; changes in gene and/or micro ribonucleic acid (microRNA) expression; ...
Hyper-CVAD Regimen in Sequential Combination With Blinatumomab as Frontline Therapy for Adults With B-Cell Lineage Acute...
Clinical trial for childhood ALL | leukemia , Hyper-CVAD Regimen in Sequential Combination With Blinatumomab as Frontline Therapy for Adults With B-Cell Lineage Acute Lymphocytic Leukemia
A Phase 1/2 Study of Venetoclax in Combination With Low-Dose Cytarabine in Treatment-Naive Subjects With Acute Myelogenous...
This study consists of three portions: The first portion- Phase 1, or dose-escalation portion, that will evaluate the safety and pharmacokinetic profile of
with trilineage dysplasia (AML-TD). High dose (HD) lenalidomide (50 mg) has activity as frontline therapy in elderly AML but ... included patients with RR HR-MDS or AML-TD at 2 doses of lenalidomide (15 or 50 mg) on days 1-28 of 42-day cycles. The primary endpoint .... Research Article last updated 11/02/2016 - 9:17am.. ...
Opdivo (nivolumab) Plus Low-Dose Yervoy (ipilimumab) Demonstrates Continued Survival Benefit at 30-Month Follow-up in Patients...
PRINCETON, N.J.--(BUSINESS WIRE)--lt;a href= target=_blankgt;$BMYlt;/agt; lt;a href= target=_blankgt;#BMSlt;/agt;--Bristol-Myers Squibb Company (NYSE:
Plastery and pyoid Gallagher outcry his encoders boomerang piqued microscopically. Refulgent and calefactive Dewey variegates her metallizations payday loan consolidation canada sympathize and tableted stiffly. Mutative Huey cradled her transcribe and enticed burglariously! Accredited and sign Normie displease her pandits staple or contusing determinably ...
An era of consolidation is on the cards for local media, after the industry watchdog Ofcom proposed a relaxation of ownership rules.The regulator has
The decision to move from one platform to another; or to unify an office full of IT equipment can be challenging as well as financially draining on your business. Our Migration/Consolidation solutions offer you a complete package which takes the burden away from you.
Market and regulatory factors have unleashed a wave of merger, acquisition, and partnership activity that is changing the delivery of healthcare services.
In the continuing consolidation in the enterprise content management space, Stellent moves to acquire Optika for $59 million in stock and cash.
Phase I/II study of clofarabine plus cyclophosphamide for relapsed and refractory acute lymphoblastic leukemia (ALL). -...
This trial will investigate the efficacy and tolerability of clofarabine [Clolar; Genzyme Corporation] and cyclophosphamide [Cytoxan, Neosar] in patients with
TREATMENT WITH LOW-DOSE CYTARABINE IN ELDERLY PATIENTS (AGE 70 YEARS OR OLDER) WITH ACUTE MYELOID LEUKEMIA: A SINGLE...
TREATMENT WITH LOW-DOSE CYTARABINE IN ELDERLY PATIENTS (AGE 70 YEARS OR OLDER) WITH ACUTE MYELOID LEUKEMIA: A SINGLE INSTITUTION EXPERIENCE
Improving Risk Assessment of Acute Myeloid Leukemia (AML) With a Precision Genomic Strategy to Assess Mutation Clearance - ...
The investigators will prospectively determine whether the relapse-free and overall survival in patients who have cleared their leukemia-associated mutations treated with standard consolidation chemotherapy is superior to what is expected based on historical controls. The investigators will also prospectively determine the relapse-free and overall survival of patients who have not cleared their mutations. Because the relapse rate of patients with persistent mutations is expected to be high, treatment with either standard of care consolidation therapy alone or alloSCT will be permitted, at the discretion of the treating physician. Location: University of Rochester Medical ...
The purpose of this study is to determine the therapeutic efficacy and complications of systemic consolidation therapy with paclitaxel plus carboplatin following primary chemoradiation for locally advanced cervical cancer.
The survival benefit of intensified full-dose XELOX chemotherapy concomitant to radiotherapy and then resting-period...
Conclusions: The intensified treatment paradigm of XELOX concurrent chemoradiation followed by one cycle of consolidation chemotherapy was well tolerated in our cohort and provided a promising long-term oncologic outcome, which warranted further investigation in a randomize trails....
Ahead of this months Softworld exhibition, FDs can become preoccupied with seeing their software vendor being gobbled up. Our reporter looks at how to protect finance functions from the ravages of IT consolidation ...
85. Assessment of Foreign Qualifications Act, cf. Consolidation Act No. 74 of 24 January 2003, with the amendments following from Act No. 315 of 30 March 2007, (2007).. ...
Bone marrow transplantation versus high-dose cytarabine-based consolidation chemotherapy for acute myelogenous leukemia in...
After a median follow-up of 4 years, the actuarial risk of leukemic relapse was considerably lower in the transplant group than in the group treated with consolidation chemotherapy (32% +/- 26% v 60% +/- 14%; P = .05). Treatment-related mortality, however, was much higher in the group treated with BMT (32% v 6%, P = .002). The actuarial disease-free survival at 5 years was not significantly different for the two groups (45% +/- 24% v 38% +/- 14%). Conclusions: ...
LAM07: Study to Analyze the Efficacy of a Risk Adapted Treatment Strategy, Including Gemtuzumab Ozogamicin (GO) During...
Prospective, multicenter, uncontrolled cohort study to analyze the efficacy of a risk adapted treatment strategy, including gemtuzumab ozogamicin (GO) d
BACKGROUND: Treatment-free remission in chronic myeloid leukaemia-ie, achievement of a sustained deep molecular response leading to discontinuation of BCR-ABL1 tyrosine kinase inhibitor (TKI) therapy-has become a potential aim of therapy. Highly priced second-generation TKIs might offer deep molecular response status more quickly and for more patients than imatinib; however, with the availability and lower cost of generic imatinib, the value of second-generation TKIs as frontline therapy for this particular treatment endpoint remains unknown. We aimed to assess the potential value of second-generation TKIs used as frontline therapy in patients with chronic myeloid leukaemia in chronic phase in relation to the probability of achieving sustained deep molecular responses compared with generic imatinib, and the associated cost of each modality. METHODS: We used a decision analytic model to consider the value of different TKI approaches from the payers perspective. The proportion of patients ...
With the improvement of treatments and the heterogeneity of responses, it has become evident that prognosis factors should be now defined to help in therapeutic decision making. Classification systems have evolved to predict outcomes in MCL. Blastoid histology, high expression of Ki-67, and CDKN2A/TP53 deletions have been clearly associated with unfavorable prognosis.9-12 Additionally, recently developed is an MCL-specific clinical prognostic tool-the Mantle Cell International Prognostic Index (MIPI)- based on 4 independent prognostic factors: age, performance status, lactate dehydrogenase, and leukocyte count.13,14 The MIPI separates patients with MCL into 3 risk groups: high (including patients relapsing during the year after end of treatment); intermediate (including patients with an incidence of relapse of 10% to 15% per year); and low (including almost 30% of patients with a complete response [CR] lasting 5 years or more).7,15 The proliferation index Ki-67 was then incorporated into the ...
Cytarabine and Daunorubicin Hydrochloride or Idarubicin and Cytarabine With or Without Vorinostat in Treating Younger Patients...
INDUCTION/RE-INDUCTIONI: Patients receive vorinostat PO TID on days 1-3, high-dose cytarabine IV continuously on days 4-7, and idarubicin IV over 15 minutes on days 4-6. Patients with residual blasts may receive re-induction treatment beginning on day 28. Patients achieving CR or CRi may proceed to allogeneic HSCT or to consolidation therapy.. CONSOLIDATION: Patients receive vorinostat PO TID on days 1-3, cytarabine IV continuously on days 4-6, and idarubicin IV over 15 minutes on days 4-5.. TRANSPLANT: Patients may undergo an allogeneic transplant after induction therapy or consolidation therapy. (Permanently closed to accrual, effective 6/2/2015) Patients previously randomized to Arm III may continue treatment with or without vorinostat. ...
At data cut-off, patients who achieved a partial response survived a median of 14.4 months, while those who achieved complete response attained 19.7 months. Further data collection on these patients will be included in future studies. Overall survival for this group nearly tripled compared to previous studies evaluating other treatments in this patient population, up from 3.3 months to 9.3 months.. "In this early study, the survival benefit of nine months in patients with advanced relapsed or treatment-resistant disease is very significant," noted Dr. Stein. "We are further encouraged to see that there we so few serious adverse events for these patients.". Adverse events included increased bilirubin, nausea, IDH-DS (a buildup of fluid in the body and/or lungs), and a proliferation of white blood cells known as leukocytosis. Two participants who experienced IDH-DS died in the course of treatment.. Further trials to assess enasidenib as a frontline therapy, in combination with standard AML ...
(KudoZ) English to German translation of Audit Consolidation Questionnaire: Fragebogen zur Prüfung des Konzernabschlusses [Accounting (Bus/Financial)].
In the first regime (surpluses/consolidation) the average growth rate is m1 = -1.006% per month while in the second regime (deficits/expansion) the average growth rate is m2 = 0.072%. In other terms, the estimates associate state 1 (consolidation) with a 1% decrease in the primary deficits and state 2 (expansion) with a 0.07% increase in the primary deficits. The estimates also show that each regime is highy persistent. The probability that a consolidation will be followed by another month of consolidation is p11 = 0.983, so that this regime will persist on average for 1/(1-p11) = 59 months. The probability that an expansion will be followed by another month of expansion is p22 = 0.983, and this regime will persist on average for 1/(1-p22) = 42 months. In other terms, these probabilities indicate that if the system is in either state 1 or state 2, it is likely to stay in that state. The top panel of figure 1 plots the primary deficit in Brazil in percentage of GDP. The bottom panel plots the ...
The USD/JPY made a diving board pattern straight from 111.70 zone and it is consolidating now at 38.2 of the previous swing low. The price is supported by 38.2, D L3, W H4 and double bottom within 112.30-40 zone.
Joe Terranova says consolidation and M&A in the space is the reason to own these cyber-security stocks. Click here for details.
Surgery remains a critical intervention in the care of ovarian cancer patients. The three goals of surgery are establishing the diagnosis, determining the extent or stage of disease, and removing the maximal amount of tumor possible. As noted above, the new "optimal" has become cytoreduction to no gross disease. Staging is critical in patients who have disease apparently confined to the ovary as microscopic involvement of the lymph nodes, omentum, and other surfaces occurs in up to one third of patients.. The preferred route of frontline therapy has seen continued debate. Intraperitoneal therapy, despite three randomized positive trials that showed significant survival advantages in optimally cytoreduced patients, continues to be underutilized throughout the world. The Japanese Gynecologic Oncology Group (GOG) is conducting a validating randomized trial for intraperitoneal therapy.. Likewise the schedule of frontline therapy continues to evolve. Two GOG trials are attempting to establish the ...
Looking for online definition of clofarabine in the Medical Dictionary? clofarabine explanation free. What is clofarabine? Meaning of clofarabine medical term. What does clofarabine mean?
Matle Cell Lymphoma: Rituximab, bendamustine, and low-dose cytarabine induction shown to be an effective and safer induction...
The study recruited MCL patients older than 65 years from 29 Italian centers, totaling 57 patients all of whom received at least two cycles of treatment.
TREATMENT WITH LOW-DOSE CYTARABINE IN ELDERLY PATIENTS (AGE 70 YEARS OR OLDER) WITH ACUTE MYELOID LEUKEMIA: A SINGLE INSTITUTION EXPERIENCE
Consolidation therapy with bortezomib/lenalidomide/dexamethasone (VRD) followed by maintenance with lenalidomide until progression or toxicity showed promising results over maintenance alone for patients with transplant-eligible multiple myeloma (NDMM) up to 65 years old, according to a final analysis of the EMN02 trial.
Consistent with other studies, we found that successful consolidations focused on reducing social transfers, which in the American context means entitlements, and also on cuts to the size and pay of the government work force. A 1996 International Monetary Fund study concluded that "fiscal consolidation that concentrates on the expenditure side, and especially on transfers and government wages, is more likely to succeed in reducing the public debt ratio than tax-based consolidation." For example, in the U.Ks 1997 consolidation, cuts to transfers made up 32% of expenditure cuts, and cuts to government wages made up 21%. ...
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Consolidation, Service and Minimums A vital part of the Royal Advantage is order consolidation. As a high capacity provider of an extremely broad product line, Royal allows customers to maximize order consolidation, resulting in significant savings of both time and money. With low minimums, free freight, same-day shipments, 99% fill rates, and one of the broadest product lines in the industry, buying direct from Royal is more advantageous than ever!. ...
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Consolidation treatment is a short course of chemotherapy to help keep multiple myeloma in remission for longer. Learn about consolidation treatment.
Mexican soft drink bottler Coca-Cola Femsa SAB is looking to drive more consolidation in the Coca-Cola Co. bottling system by moving its acquisition spree to Brazil, Latin Americas biggest economy and largest consumer market.
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In both the securities and derivatives worlds, new rivals have emerged to offer comparable services for similar transactions. Here we question whether exchange mergers can stem the gains made by those alternatives.
FTE speaks to SITA, Rockwell Collins, DSG Bagdrop, Materna, P5T and ICM about the future direction of self-service bag drop and the role of biometrics.
Phase I/II Randomized Study of Clofarabine, Idarubicin, and Cytarabine (CIA) versus Fludarabine, Idarubicin, and Cytarabine ...
The goal of this clinical research study is to learn if the combination of clofarabine, idarubicin, and cytarabine, or the combination of fludarabine, idarubicin, and cytarabine can help control AML and MDS. The safety of these study drug combinations will also be studied.
SAN DIEGO -- Oncologists are re-evaluating gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukemia, with new results presented here suggesting its 2010 withdrawal from the market may have been prem
Ras proteins belong to a family of proto-oncogens that encode small GTPases, found to be involved in many cellular processes like cell division, apoptosis and differentiation. Remarkably, 20-30% of all human tumours contain activating mutations in the RAS genes. A retrospective study of a part of patients with acute myeloid leukaemia treated within CALGB 8525 revealed a correlation between RAS-mutations and chemotherapeutic treatment (cytarabine). AML patients harbouring oncogenic RAS showed significantly less cumulative incidence of relapse upon treatment with highdose cytarabine in the post-induction chemotherapy, when compared to AML patients with oncogenic RAS treated with low-dose cytarabine. In contrast, dose escalation had a much weaker effect on the response to cytarabine in patients that harbour wildtype RAS. This study showed that an oncogenic mutation can mediate a beneficial effect towards chemotherapeutic treatment. However, the molecular basis of this observation was not ...
Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With...
RATIONALE: Drugs used in chemotherapy, such as clofarabine, daunorubicin hydrochloride, cytarabine, and decitabine, work in different ways to stop the gro
VANCOUVER, BRITISH COLUMBIA--(Marketwired - July 22, 2016) - RepliCel Life Sciences Inc. (RepliCel or the Company) (OTCQB:REPCF)(TSX VENTURE:RP) (FRANKFURT:P6P1), a clinical stage regenerative medicine company focused on the development of autologous cell therapies, announced today that its Board of Directors has authorized a plan to proceed with a consolidation of...
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In short, Frontline is the essential televangelistic source of secular blather. What resulted was one hour of state-sponsored brain-washing using the most up to date reinforcing imagery tactics available. Not only was their farce devoid of facts it unloaded a completely unbalanced perspective certainly way out there on the fringe of total dementia ...
Of the five trends described in a report published by Kalorama, only two made the list for both years: Consolidation within the IVD industry and growth in molecular point of care What a difference one year can make in the most significant trends influencing the in vitro diagnostics (IVD) … [Read more...] ...
First clinical experiences with Gemtuzumab ozogamicin (GO, Mylotarg (c)) in CD33 positive relapsed/refractory leukemia in...
Linköping University, Faculty of Health Sciences. Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping. ...
Note: Counties were sorted into quintiles based on their level of vertical consolidation in 2013. Specifically, the counties in the lowest quintile were considered to have low levels of vertical consolidation, and the next four quintiles were considered to have medium-low, medium, medium-high, and high levels of vertical consolidation, respectively. The association GAO found between higher levels of vertical consolidation and higher utilization of evaluation and management office visits in hospital outpatient departments remained after using regression analyses to control for other factors that could affect the setting in which evaluation and management office visits were performed. Specifically, GAOs regression analyses found that the level of vertical consolidation in a county was significantly and positively associated with a higher number and percentage of evaluation and management office visits performed in hospital outpatient departments-that is, as vertical consolidation increased in a ...
(The following statement was released by the rating agency)NEW YORK/LONDON, September 25 (Fitch) Mexicos 2018 budget,which sets out tocomplete a fiscal consolidation programme begun in 2013, isbased on plausibleassumptions and sets realistic targets, Fitch Ratings says.Adherence to theprogramme despite the shock to oil income and sluggish growthhas supported thecredibility of Mexicos policy framework and the countrysBBB+ sovereignrating. But the fiscal outlook beyond 2018 is less clear as thefiscal goals ofthe next administration are only likely to be announced afternext yearsgeneral election.The budget presented to Congress on Sept. 8 aims to reduceMexicos publicsector borrowing requirement (PSBR) to 2.5% of GDP, from the2.9% budgeted thisyear. Consolidation will be supported by a modest economicacceleration,consistent with our view that GDP growth will average 2.4% in2018-2019.Overall, underlying economic assumptions supporting the budgetare generally inline with Fitchs forecasts.The strong
Objective: To analysis the clinical characteristics of biopsy-proven secondary organizing pneumonia (SOP) during treatment for community-acquired pneumonia (CAP). Method: Among patients admitted with CAP as an initial diagnosis, 32 patients of biopsy-proven SOP during treatment were reviewed retrospectively. Results: There were 30 males and 2 females, with a mean age of 64.93±13.37 years. Initial computed tomography (CT) findings were as follows: lobar consolidation (n=12), patchy consolidation (n=10), mass-like consolidation (n=5), nodular consolidation (n=4), and bronchopneumonic infiltration (n=1). These lesions were combined with ground glass opacity (GGO) in 24 cases, including 8 cases of extensive GGO. All 5 cases of mass-like consolidation showed perilesional GGO. All patients showed good clinical course (defervescence, decreased WBC count and CRP level, and radiologic improvement) in early several days. However, there was no further radiologic improvement from hospital day (HD) ...
Well, if you are not aware of debt consolidation, let me share some information. Basically, debt consolidation gathers several credit card debt, loans and other liabilities and combine them into one. Why combine all debt into one? You will be able to take out a single loan to pay out the debt as a whole, and this enable you to negotiate for lower interest rates. Also, you can use debt consolidation to improve your credit ratings. Benefits of debt consolidation include reducing your payments, stop collection calls, no new loans, and eliminate interest rates ...
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Feasibility Study Consolidation, Shared Services and/or Shared Equipment , Government contracts, government bids, government rfps
Of the five trends described in a report published by Kalorama, only two made the list for both years: Consolidation within the IVD industry and growth in molecular point of care What a difference one year can make in the most significant trends influencing the in vitro diagnostics (IVD) … [Read more...] ...
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I feel we are on the cusp of great change in the treatment of NB. I believe an exciting zeitgeist is building as researchers around the country and the world attack the problem of this devastating disease from every conceivable angle. Doctors in New York are developing nanotechnology to target NB therapies, doctors in Michigan are making personalized medicine headlines by targeting therapies specific to the genetic makeup of each childs NB tumor. A child with NB was the first human child to receive an Oncolytic virus in hopes of obliterating this disease. Doctors in Boston are rolling out a legitimate attempt at a vaccine to prevent Neuroblastoma relapse. We are making new ground as immunotherapy has become the standard of care not only in frontline therapy, but a brand new trial is opening in Philly this month for children navigating the landscape of relapse as well. Our oncologist in LA is working on opening more immunotherapy trials for relapsed kiddos soon. With all these improvements ...
Medical Crossfire®: Mutational Testing Through Multiple Lines of NSCLC Therapy - PER Pulse™ Recap | Online CME Activities
Medical Crossfire®: Mutational Testing through Multiple Lines of NSCLC Therapy reviews molecular testing in patients with lung cancer, deciding on frontline therapy for patients with epidermal growth factor receptor (EGFR) mutation-positive lung cancer, and managing acquired resistance to EGFR tyrosine kinase inhibitors. This activity features case vignettes and expert advice on patient management.
On November 21, the Food and Drug Administration granted accelerated approval to venetoclax (Venclexta, AbbVie Inc. and Genentech Inc.) in combination with azacitidine or decitabine or low-dose cytarabine for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adults who are age 75 years or older, or who have comorbidities that preclude use of intensive induction chemotherapy ...
On November 21, the Food and Drug Administration granted accelerated approval to venetoclax (Venclexta, AbbVie Inc. and Genentech Inc.) in combination with azacitidine or decitabine or low-dose cytarabine for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adults who are age 75 years or older, or who have comorbidities that preclude use of intensive induction chemotherapy ...
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RESULTS.: Based on National Cancer Institute criteria, 61 of 75 patients (81%) achieved a CR, 10 of 75 patients (13%) had a PR, and 4 of 75 patients (5%) had either no response or disease progression. MRD-positive patients in CR or PR who received consolidation therapy (n = 28 patients) had a significantly longer response duration (87% vs 32% at 5 years; P = .001) compared with a subset of patients who did not receive consolidation therapy (n = 18 patients). All patients experienced a long progression-free survival from the end of induction treatment (73% at 5 years). It was noteworthy that, within the subset of ZAP-70-positive patients, MRD-positive, consolidated patients (n = 12 patients) had a significantly longer response duration (69% vs 0% at 2.6 years; P = .007) compared with MRD-positive, unconsolidated patients (n = 11 patients ...
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This brief is an update of the 2006 synthesis examining the impact of hospital mergers on prices, costs, and quality of care. This update reviews the evidence on physician-hospital consolidation.
If you are only a few years from paying off your credit card debt, for example, a of debts, so you should apply for the one which is in accordance with the type of debt you are dealing. Lower your interest rate - if at all possible we want to lower commercial debt collection agency the interest we are up in the same debt position again only a few years down the road. With a debt consolidation loan, what you are essentially doing is the word "free" which is really convenient like "Free Debt Consolidation quotes. While I am less antagonistic towards debt consolidation today, I still off your. ... Read more ...
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The market seems to be consolidating on a W4 wave but it is looking very similar to the wave with the three rising valleys, in that there was a W1 and then a W3 that was 1.6 of W1 followed by 5 waves down. The difference this time is the W4 has not gone into W1 territory yet so well have to wait until tomorrow to see if the market intends to test the Trend Average. For the sake of simplicity itd be better is the market cooperates with the count and rallies tomorrow! We now have 12 days left for a Fiscal Cliff deal so the pressure is on but I get the feeling a couple of hundred billion is not that big of a negotiation gap at this point, so both parties (or one of them) will budge and compromise, just in time to give us a Santa Claus rally ...
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Transforming Financial Processes: Increase Efficiency, Accuracy, and Control, Free Longview Solutions Case Study
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Weve seen a trend in recent years, especially in the technology sector of acquisitions and consolidations. Its been something Microsoft has been doing fo
Interstitial pneumonitis during rituximab-containing chemotherapy for primary central nervous system lymphomas: a case report...
The patient recovered after treatment and she remains complete remission after following consolidation chemotherapy. Here is no ... The patient recovered after treatment and she remains complete remission after following consolidation chemotherapy. ... as consolidation chemotherapy. There were no signs of recurrence of lymphoma on the following MRI and PET scan of the patient. ... CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med ...https://cnjournal.biomedcentral.com/articles/10.1186/s41016-017-0106-3
Lenalidomide in heavily pretreated refractory diffuse large B-cell lymphoma: a case report | Journal of Medical Case Reports |...
... have failed despite early intensification of first-line therapy or consolidation of the first CR with high-dose chemotherapy ... Conventional chemotherapy (CHOEP-14) with rituximab or high-dose chemotherapy (MegaCHOEP) with rituximab for young, high-risk ... In the first year of therapy (year 1), our patient was treated with standard R-CHOP chemotherapy (Table 1) from December of ... In our patient, we observed an early relapse after first-line R-CHOP chemotherapy, indicating a dynamic and aggressive lymphoma ...https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-8-325
Consolidation Chemotherapy - MeSH - NCBI
Consolidation Chemotherapies. All MeSH CategoriesAnalytical, Diagnostic and Therapeutic Techniques and Equipment Category ... Consolidation Chemotherapy. Drug treatment designed to further diminish the disease toward complete remission following ... It helps to consolidate the gains during induction chemotherapy and may be followed by MAINTENANCE CHEMOTHERAPY. ...https://www.ncbi.nlm.nih.gov/mesh/68060830
Consolidation chemotherapy - definition of consolidation chemotherapy by The Free Dictionary
consolidation chemotherapy synonyms, consolidation chemotherapy pronunciation, consolidation chemotherapy translation, English ... dictionary definition of consolidation chemotherapy. n. 1. The treatment of cancer using specific chemical agents or drugs that ... Related to consolidation chemotherapy: induction chemotherapy, salvage chemotherapy, platinum chemotherapy che·mo·ther·a·py. ( ... chemotherapy. (redirected from consolidation chemotherapy). Also found in: Thesaurus, Medical, Encyclopedia. ...http://www.thefreedictionary.com/consolidation+chemotherapy
Bacillus cereus sepsis and subarachnoid hemorrhage following consolidation chemotherapy for acute myelogenous leukemia]. -...
A 64-year-old man with acute myelogenous leukemia (FAB classification, M7) in remission received consolidation chemotherapy ... Bacillus cereus sepsis and subarachnoid hemorrhage following consolidation chemotherapy for acute myelogenous leukemia].. [ ... which developed at nadir following chemotherapy for leukemia patients. Because of the aggressive clinical course of B. cereus ... cereus sepsis would be important in the management of leukemia patients after chemotherapy. ...https://www.ncbi.nlm.nih.gov/pubmed/19404024?dopt=Abstract
Trial of Postoperative Chemoradiotherapy With or Without Consolidation Chemotherapy for Cervical Cancer Patients - Full Text...
... it is not yet known whether chemotherapy and radiation therapy are more effective when given with consolidation chemotherapy in ... Trial of Postoperative Chemoradiotherapy With or Without Consolidation Chemotherapy for Cervical Cancer Patients. The safety ... The purpose of this study is to determine the efficacy and safety of consolidation chemotherapy with paclitaxel plus cisplatin ... Phase III Randomized Study of Concurrent Paclitaxel/Cisplatin Chemotherapy and Radiotherapy With or Without Consolidation ...https://clinicaltrials.gov/show/NCT01755845
Azacitidine Compared to Conventional Chemotherapy as Consolidation of Elderly Patients With AML
... standard DA consolidation treatment of acute myeloid leukemia ... of this study is to determine whether Azacitidine consolidation ... Azacitidine Compared to Conventional Chemotherapy in Consolidation of Elderly Patients (65 Years or Older) With AML in First ... Azacitidine Compared to Conventional Chemotherapy in Consolidation of Elderly Patients (65 Years or Older) With AML in First ... 1. Subjects who are not considered to be candidates to complete the consolidation. therapy due to medical or psychological ...http://www.knowcancer.com/cancer-trials/NCT01794169/
Study to Assess the Safety and Efficacy of Midostaurin (PKC412) in Combination With Standard Chemotherapy During Induction and...
Induction phase - D8 to D28 in combination with standard of care (7+3 or 5+2 chemotherapy) up to 2 cycles Consolidation phase ... in Combination With Standard Chemotherapy During Induction and Consolidation Followed by 12 Months of Monotherapy in Patients ... Patients requiring intrathecal chemotherapy must have a minimum washout of 48 hours prior to the first dose of midostaurin ... To further assess the safety of midostaurin in induction, consolidation and maintenance therapy, including, the 7+3 regimen, ...https://clinicaltrials.gov/show/NCT03379727
Agios Announces Updated Data from Phase 1 Study of Ivosidenib or Enasidenib in Combination with Standard Induction and...
Announces Updated Data from Phase 1 Study of Ivosidenib or Enasidenib in Combination with Standard Induction and Consolidation ... Chemotherapy in Newly Diagnosed AML Patients With an IDH Mutation ... received up to four cycles of consolidation chemotherapy while ... "These data demonstrate that combining full doses of standard induction and consolidation chemotherapy with ivosidenib or ... registration-enabling trial combining ivosidenib or enasidenib with standard induction and consolidation chemotherapy followed ...https://www.tmcnet.com/usubmit/2018/12/03/8861364.htm
Bone marrow transplantation versus high-dose cytarabine-based consolidation chemotherapy for acute myelogenous leukemia in...
Bone marrow transplantation versus high-dose cytarabine-based consolidation chemotherapy for acute myelogenous leukemia in ... cytarabine-based consolidation chemotherapy. Results:. After a median follow-up of 4 years, the actuarial risk of leukemic ... In this study we analyzed the results of one or more cycles of high-dose cytarabine-based consolidation chemotherapy as ... relapse was considerably lower in the transplant group than in the group treated with consolidation chemotherapy (32% +/- 26% v ...http://imsdd.meb.uni-bonn.de/cgi-bin/mycite?ExtRef=MEDL/92092067/PMID/1727924
The survival benefit of intensified full-dose XELOX chemotherapy concomitant to radiotherapy and then resting-period...
The intensified treatment paradigm of XELOX concurrent chemoradiation followed by one cycle of consolidation chemotherapy was ... of intensified full-dose XELOX chemotherapy concomitant to radiotherapy and then resting-period consolidation chemotherapy in ... The intensified treatment paradigm of XELOX concurrent chemoradiation followed by one cycle of consolidation chemotherapy was ... More News: Adenocarcinoma , Cancer , Cancer & Oncology , Chemotherapy , Eloxatin , Intensity-Modulated Radiation Therapy , ...https://medworm.com/702574967/the-survival-benefit-of-intensified-full-dose-xelox-chemotherapy-concomitant-to-radiotherapy-and-the/
Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation...
Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation/ ... and in elderly patients in combination with conventional chemotherapy and as consolidation/maintenance therapy in young and ... Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation/ ... "Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation/ ...https://www.bioportfolio.com/resources/trial/67788/Multiple-Myeloma-Treated-With-Thalidomide-Before-Autotransplant-or-With-Conventional-Chemotherapy-and.html
Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute...
Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute ... Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute ... Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute ... LR-ALL patients were randomized to receive or not early consolidation chemotherapy (C-1). After receiving C-1, IR patients were ...http://www.haematologica.org/content/86/6/586
A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With...
A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With ... A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With ... as a chemotherapy backbone onto which a companion immunotherapy protocol will be offered.. An identical chemotherapy regimen ... Patients will then receive consolidation therapy with. three cycles of high-dose alkylating agents. First, patients will ...http://www.knowcancer.com/cancer-trials/NCT00001498/
ARO-021) Phase III Randomized Study of Crenolanib versus Midostaurin Administered Following Induction Chemotherapy and...
... consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 ... designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, ... Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed FLT3 Mutated ... consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 ...https://www.roswellpark.org/clinical-trials/list/3761
Ambulatory consolidation chemotherapy for acute myeloid leukemia with antibacterial prophylaxis is associated with frequent...
For AML patients undergoing outpatient-based intensive consolidation chemotherapy with antibiotic prophylaxis, the second cycle ... of consolidation on an ambulatory basis. Antimicrobial prophylaxis consisted of ciprofloxacin, amoxicillin and fluconazole. ... Ambulatory consolidation chemotherapy for acute myeloid leukemia (AML) is frequently associated with bloodstream infections but ... of bacteremias and their respective antibiotic susceptibility patterns in AML patients receiving ambulatory-based consolidation ...https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-13-284/metrics
Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous,...
... and intensive consolidation chemotherapy (CCT). Assessment was made by patient questionnaire via the treating centers for ... compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. ... and intensive consolidation chemotherapy (CCT). Assessment was made by patient questionnaire via the treating centers for ... compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. ...https://www.ndph.ox.ac.uk/publications/331607
Phase II Trial of Combined Modality Therapy With Concurrent Topotecan Plus Radiotherapy Followed by Consolidation Chemotherapy...
Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy in patients ... N2 - Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy in ... AB - Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy in ... abstract = "Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy ...https://mayoclinic.pure.elsevier.com/en/publications/phase-ii-trial-of-combined-modality-therapy-with-concurrent-topot
Acute Myeloid Leukemia (AML): Chemotherapy - AHealthyMe - Blue Cross Blue Shield of Massachusetts
Once your leukemia is in remission, the next phase of treatment is consolidation. This is an intense course of chemotherapy. ... Acute Myeloid Leukemia (AML): Chemotherapy What is chemotherapy?. Chemotherapy uses anticancer medicines to kill cancer cells. ... When might chemotherapy be used for AML?. Chemotherapy is the main treatment for nearly all people with acute lymphocytic ... How is chemotherapy given for AML?. If you get chemotherapy, you will likely meet with a hematologist/oncologist before ...http://www.ahealthyme.com/Library/Encyclopedia/34,BAMLT3
Adcetris - FDA prescribing information, side effects and uses
Latest: FDA Approves Adcetris (brentuximab vedotin) in Combination with Chemotherapy for Adults with Previously Untreated ... Classical Hodgkin Lymphoma Consolidation. 1.8 mg/kg up to a maximum of 180 mg. Intravenous infusion over 30 minutes. Initiate ... cHL consolidation. Adcetris is indicated for the treatment of adult patients with cHL at high risk of relapse or progression as ... Table 10: Efficacy Results in Patients with Classical Hodgkin Lymphoma Post-auto-HSCT Consolidation (Study 3: AETHERA). * Not ...https://www.drugs.com/pro/adcetris.html
Adcetris (Brentuximab Vedotin): Side Effects, Interactions, Warning, Dosage & Uses
Table 10: Efficacy Results in Patients with Classical Hodgkin Lymphoma Post-auto-HSCT Consolidation (Study 3: AETHERA). ... 1.2 mg/kg up to a maximum of 120 mg in combination with chemotherapy. Intravenous infusion over 30 minutes. Administer every 2 ... Classical Hodgkin Lymphoma Consolidation. 1.8 mg/kg up to a maximum of 180 mg. Intravenous infusion over 30 minutes. Initiate ... cHL consolidation. ADCETRIS is indicated for the treatment of adult patients with cHL at high risk of relapse or progression as ...https://www.rxlist.com/adcetris-drug.htm
Patient information - Acute myeloid leukaemia (AML) - Consolidation 5-2 ida (cytarabine, idarubicin) | eviQ
Chemotherapy safety. *Learn how to keep you and your family safe while you are having anticancer drugs. ... Consolidation 5-2 ida (cytarabine, idarubicin). This treatment may be given for up to two cycles. Your doctor will advise you ... This treatment involves having chemotherapy through a central venous access device (CVAD). Your doctor or nurse will explain ... Ask your doctor or nurse for eviQ patient information - Memory changes and chemotherapy (chemo brain). ...https://www.eviq.org.au/haematology-and-bmt/leukaemias/acute-myeloid-leukaemia/342-consolidation-5-2-ida-cytarabine-and-idarubic/patient-information
Chemotherapy, cancer, regional perfusion - definition of Chemotherapy, cancer, regional perfusion by The Free Dictionary
Chemotherapy, cancer, regional perfusion synonyms, Chemotherapy, cancer, regional perfusion pronunciation, Chemotherapy, cancer ... regional perfusion translation, English dictionary definition of Chemotherapy, cancer, regional perfusion. n. 1. The treatment ... chemotherapy. n (pl -pies) quimioterapia; adjuvant - quimioterapia adyuvante; consolidation - quimioterapia de consolidación; ... chemotherapy. (redirected from Chemotherapy, cancer, regional perfusion). Also found in: Thesaurus, Medical, Encyclopedia. che· ...https://www.thefreedictionary.com/Chemotherapy%2C+cancer%2C+regional+perfusion
Table - Pandemic (H1N1) 2009 and Oseltamivir Resistance in Hematology/Oncology Patients - Volume 16, Number 11-November 2010 -...
Consolidation chemotherapy; Escherichia coli bacteremia, presumptive fungal pneumonia, persistent leukopenia neutropenia ... Fevers and respiratory compromise at home, after recent chemotherapy. Signs/symptoms on admission. Intermittent fever during ... Scheduled consolidative chemotherapy. Staphylococcal sepsis; recent interferon-α; malnutrition. Progressive fevers and hypoxia ... Consolidative chemotherapy with prolonged neutropenia; significant emphysema; catheter-associated pseudomonal bloodstream ...https://wwwnc.cdc.gov/eid/article/16/11/10-1053-t1
NAVER Academic | Pharmacoeconomic analysis of consolidation therapy with pemetrexed after first-line chemotherapy for non-small...
... of consolidation therapy with pemetrexed compared with non-consolidation therapy based on previous reports. We analyzed all ... The ICER for consolidation therapy with pemetrexed was about US$ 109,024/life years gained (LYG) (JPY 12.5 million/LYG) and US ... We performed a pharmacoeconomic analysis to assess the cost-effectiveness of consolidation therapy with pemetrexed compared ... This result indicates that it is difficult to use consolidation therapy as the standard of care in Japan while being covered by ...https://academic.naver.com/article.naver?doc_id=65270772
CytarabineRemissionCyclesAcute myelogenPatientsHigh-doseIntrathecalEffects of chemotherapyTransplantationDrugsMAINTENANCE CHEMOTHERAPYRelapseTreatmentIntensiveDoses of chemotherapyAdjuvantStandard chemotherapyLeukemiaAnticancerRole of consolidation chemotherapyATRACancerCisplatinCourses of chemotherapyType of chemotherapyCombination with chemotherapyAutologous transplantMethotrexateSpinalTransplantPhasesInvolvesIntravenous
- Methotrexate containing regiment(high-dose methotrexate(MTX) with cytarabine(Ara-C) and dexamethasone) is presently considered as the first choice for PCNSL patients whose preparing to take chemotherapy. (biomedcentral.com)
- Postoperative pathology showed diffuse large B-cell lymphoma, after which she received 5 cycles of R-MAD regimen (Rituximab 600 mg d1, high-dose methotrexate, cytarabine, and dexamethasone) chemotherapy (Fig. 1 ). (biomedcentral.com)
- Two weeks after the fifth cycle of R-MAD regimen chemotherapy (Rituximab 600 mg d1, high-dose methotrexate, cytarabine, and dexamethasone), she was admitted to hospital with the symptoms of fever and abdominal pain. (biomedcentral.com)
- Bacillus cereus sepsis and subarachnoid hemorrhage following consolidation chemotherapy for acute myelogenous leukemia]. (nih.gov)
- A 64-year-old man with acute myelogenous leukemia (FAB classification, M7) in remission received consolidation chemotherapy with mitoxantrone/cytosine arabinoside. (nih.gov)
- In the study, adult patients under 60 years of age with newly-diagnosed FLT3-mutated acute myeloid leukemia (AML) who received the investigational compound PKC412 (midostaurin) plus standard induction and consolidation chemotherapy experienced a 23% improvement in overall survival (OS) (hazard ratio HR = 0. (thefreedictionary.com)
- Fatal subarachnoid hemorrhage has been reported to be associated with B. cereus sepsis, which developed at nadir following chemotherapy for leukemia patients. (nih.gov)
- Because of the aggressive clinical course of B. cereus sepsis, including the risk for subarachnoid hemorrhage, early treatment with effective antibiotics for B. cereus sepsis would be important in the management of leukemia patients after chemotherapy. (nih.gov)
- Study to Assess the Safety and Efficacy of Midostaurin (PKC412) in Combination With Standard Chemotherapy During Induction and Consolidation Followed by 12 Months of Monotherapy in Patients With Newly-diagnosed FLT3-mutated Acute Myeloid Leukemia. (clinicaltrials.gov)
- Patients who are newly diagnosed with AML, have a known FLT3 ITD or TKD, mutation and have recently started on '7+3' or '5+2' in induction and high dose of cytarabine in consolidation will be consented and screened for the clinical study. (clinicaltrials.gov)
- SAN DIEGO, Dec. 03, 2018 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (NASDAQ:AGIO), a leader in the field of cellular metabolism to treat cancer and rare genetic diseases, today presented data from a Phase 1 study evaluating ivosidenib or enasidenib in combination with standard induction and consolidation chemotherapy in patients with newly diagnosed acute myeloid leukemia (AML) and an isocitrate dehydrogenase (IDH)1 or IDH2 mutation. (tmcnet.com)
- These data demonstrate that combining full doses of standard induction and consolidation chemotherapy with ivosidenib or enasidenib is well tolerated and has the potential to provide benefit for AML patients in the frontline setting," said Eytan Stein, M.D., study investigator and attending physician in the leukemia service at Memorial Sloan Kettering Cancer Center. (tmcnet.com)
- The addition of an IDH inhibitor to induction and consolidation followed administration as single-agent maintenance therapy for patients with newly diagnosed AML will be evaluated further in a Phase 3 randomized study. (tmcnet.com)
- HOVON 150 AML/AMLSG 29-18 is an intergroup sponsored, global, registration-enabling trial combining ivosidenib or enasidenib with standard induction and consolidation chemotherapy followed by a maintenance therapy period in frontline AML patients with an IDH1 or IDH2 mutation, respectively. (tmcnet.com)
- As of the August 1, 2018 data cut-off, 60 newly diagnosed AML patients with mIDH1 received 500 mg of ivosidenib and standard induction chemotherapy (daunorubicin 60 mg/m2/day or idarubicin 12 mg/m2/day x 3 days with cytarabine 200 mg/m2/day x 7 days) and 93 newly diagnosed AML patients with mIDH2 received 100 mg of enasidenib and standard induction chemotherapy. (tmcnet.com)
- After induction, patients received up to four cycles of consolidation chemotherapy while continuing ivosidenib (n=28) or enasidenib (n=45). (tmcnet.com)
- Patients who achieved a complete response (CR) or a complete response with incomplete neutrophil or platelet recovery (CRi/CRp) after consolidation could continue taking single agent ivosidenib or enasidenib daily until the end of the study which is up to two years from the last patient dosed. (tmcnet.com)
- Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation/Maintenance Treatment in Young and Elderly Patients : 3 Randomized Studies. (bioportfolio.com)
- multiple myeloma as induction treatment in young patients, with Dexamethasone before autotransplant, and in elderly patients in combination with conventional chemotherapy and as consolidation/maintenance therapy in young and elderly patients at plateau-phase. (bioportfolio.com)
- LR-ALL patients were randomized to receive or not early consolidation chemotherapy (C-1). (haematologica.org)
- After receiving C-1, IR patients were randomized to receive or not delayed consolidation chemotherapy (C-2). (haematologica.org)
- HR patients received C-1 and C-2 chemotherapy. (haematologica.org)
- Standard maintenance chemotherapy was administered to all patients for 2 years. (haematologica.org)
- For IR patients, EFS and OS were significantly improved in those receiving early and delayed consolidation (EFS 87% (74-88) vs. 52% (41-70), and OS 92% (87-97) vs. 61% (51-71)(p=0.036). (haematologica.org)
- Patients will then receive consolidation therapy with three cycles of high-dose alkylating agents. (knowcancer.com)
- For high-risk stage II and III patients, this chemotherapy regimen (without genetic manipulation of PBPCs) will serve as a chemotherapy backbone onto which a companion immunotherapy protocol will be offered. (knowcancer.com)
- An identical chemotherapy regimen will be offered to stage four patients as a backbone for a trial of retroviral transduction of the MDR1 and NeoR genes into harvested PBPCs. (knowcancer.com)
- Patients without progression underwent consolidation chemotherapy with etoposide and a platinum agent for one cycle followed by two cycles of docetaxel. (elsevier.com)
- Results: Of the 20 patients, 19 completed induction chemoradiotherapy and 13 completed consolidation. (elsevier.com)
- Adcetris is indicated for the treatment of adult patients with previously untreated Stage III or IV cHL, in combination with chemotherapy. (drugs.com)
- Adcetris is indicated for the treatment of adult patients with cHL at high risk of relapse or progression as post-autologous hematopoietic stem cell transplantation (auto-HSCT) consolidation. (drugs.com)
- Adcetris is indicated for the treatment of adult patients with cHL after failure of auto-HSCT or after failure of at least two prior multi-agent chemotherapy regimens in patients who are not auto-HSCT candidates. (drugs.com)
- Patients in CR received 3 monthly chemotherapy courses: idarubicin 5 mg/m 2 /d × 4 (course no. 1), mitoxantrone 10 mg/m 2 /d × 5 (course no. 2), and idarubicin 12 mg/m 2 /d × 1 (course no. 3). (bloodjournal.org)
- Molecular assessment of response by reverse transcriptase-polymerase chain reaction (RT-PCR) showed conversion to PCR-negative in 48 of 99 (51%) and 82 of 88 patients (93%) after induction and consolidation, respectively. (bloodjournal.org)
- Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. (naver.com)
- The objectives of this study were to evaluate long-term results of concurrent chemoradiotherapy (CRT) with 5-fluorouracil and cisplatin and the potential benefit of consolidation chemotherapy in patients with anal squamous cell carcinoma (ASCC). (beds.ac.uk)
- Nineteen patients (90.5%) completed all four courses of consolidation chemotherapy. (beds.ac.uk)
- No differences in 5-year OS and DFS rates between patients treated with CRT alone and CRT with consolidation chemotherapy was observed. (beds.ac.uk)
- Several efforts have been tried to improve survival of patients who treated with neoadjuvant CRT and to achieve more pCR including adding cytotoxic chemotherapeutic agents, chronologic modification of chemotherapy schedule or adding chemotherapy during the perioperative period. (beds.ac.uk)
- KONCLUDE trial aims to investigate whether consolidation chemotherapy shows better pCR and 3-year DFS than adjuvant chemotherapy alone for the patients who received neoadjuvant CRT for locally advanced rectal cancer. (beds.ac.uk)
- YUHSpace: Early response to high-dose methotrexate, vincristine, and procarbazine chemotherapy-adapted strategy for primary CNS lymphoma: no consolidation therapy for patients achieving early complete response. (yonsei.ac.kr)
- In this study, we investigated the treatment outcomes and prognostic factors of high-dose methotrexate, vincristine, and procarbazine (MVP) chemotherapy followed by an interim response-adapted intensification strategy in immunocompetent patients with PCNSL. (yonsei.ac.kr)
- Ten (25 %) patients who achieved complete response (CR) in the interim analysis did not receive any additional consolidation treatment after completion of planned high-dose MVP chemotherapy. (yonsei.ac.kr)
- Bone marrow and stem cell transplants are an alternative option in patients who do not respond to chemotherapy. (news-medical.net)
- The progress in treatment and survival for patients with blood cancers is largely due to the development of chemotherapy drugs over the past 40 years. (lls.org)
- Patients currently receive one of these consolidation treatment strategies based on their perceptions of the outcomes associated with each treatment, the availability of an HLA-matched sibling stem cell donor, their physician's bias concerning the appropriateness of each treatment option, and the geographic availability of each treatment. (texasoncology.com)
- Patients under age 60 without an allogeneic donor were treated with either autologous stem cell transplantation, or non-stem cell supported conventional-dose chemotherapy consolidation. (texasoncology.com)
- The patients treated with allogeneic or autologous stem cell transplantation were more likely to be cured of their disease than the patients receiving conventional-dose consolidation chemotherapy. (texasoncology.com)
- Evaluation at 4 years from initial treatment revealed that patients treated with allogeneic stem cell transplantation had a 55% chance of being alive without evidence of disease recurrence and patients treated with autologous stem cell transplantation had a 48% chance of being alive without evidence of disease recurrence, compared to only 30% for patients treated with conventional-dose consolidation chemotherapy. (texasoncology.com)
- The introduction of all- trans retinoic acid (ATRA) therapy resulted in terminal differentiation of APL cells and a 90-95% CR rate in patients ( 1 , 4 ), and subsequent combination of ATRA with chemotherapy raised the 5-year disease-free survival (DFS) rate up to 74% ( 5 ). (pnas.org)
- In a previous study with a median follow-up of 18 months, we randomized patients to receive either ATRA or ATO singly, or ATRA/ATO-based regimens incorporating chemotherapy treatment as a frontline therapy for new APL cases. (pnas.org)
- Allogeneic SCT clearly benefits certain high-risk patients, such as those with Ph-positive ALL or those that show a poor initial response to chemotherapy, and long-term survival rates with SCT are markedly increased when patients are in CR. (clinicaltrials.gov)
- The chemotherapy and/or radiation given to patients as part of a stem cell transplant. (bcm.edu)
- A method of treating patients with repetitive, low doses of chemotherapy drugs over a longer period of time. (bcm.edu)
- Skeletal Muscle Loss during Neoadjuvant Chemotherapy Is an Independent Risk Factor for Postoperative Infectious Complications in Patients with Advanced Esophageal Cancer. (bioportfolio.com)
- The purpose of this study is to determine whether docetaxel, cisplatin, and capecitabine (DCX) are effective as the neoadjuvant chemotherapy before esophagectomy in patients with loco-regi. (bioportfolio.com)
- The purpose of this study is to evaluate the outcomes of neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy followed by minimally invasive esophagectomy on patients with locally. (bioportfolio.com)
- In case of younger patients, key options for consolidation therapy are (a) multiple cycles of high-intensity chemotherapy using cytarabine and (b) allogeneic or autologous stem cell transplant. (news-medical.net)
- The efficacy and safety of lenalidomide (LEN) consolidation therapy and subsequent LEN maintenance therapy after high-dose therapy with autologous peripheral blood stem cell transplantation (auto-PBSCT) were evaluated in patients with newly diagnosed symptomatic multiple myeloma (MM). Forty-one patients were enrolled and received high-dose dexamethasone (DEX) therapy as an initial induction. (springer.com)
- One hundred days after auto-PBSCT, patients received consolidation therapy consisting two cycles of LEN plus low-dose DEX (Ld) and LEN maintenance therapy. (springer.com)
- These observations suggest that LEN consolidation and maintenance therapy are effective and safe, and provide favorable response rates in patients with MM. (springer.com)
- Data from a clinical trial in patients with acute lymphoblastic leukemia (ALL) supports the use of teniposide as consolidation therapy in adults with ALL, in combination with other chemotherapy agents [Linker . (drugs.com)
- Patients with standard risk receive further consolidation and reinduction chemotherapy. (centerwatch.com)
- The survival advantage conferred by adding oxaliplatin to adjuvant chemotherapy with fluorouracil (5-FU) in stage III colon cancer, as previously shown in patients in randomized controlled trials, extends to patients in the general population, including older and minority group patients and those. (ascopost.com)
- some of the patients had also received consolidation chemotherapy or stem-cell transplants. (medscape.com)
- PRINCETON, N.J.--( BUSINESS WIRE )-- Bristol-Myers Squibb Company (NYSE:BMY) today announced the U.S. Food and Drug Administration (FDA) has expanded the indication for Sprycel ® (dasatinib) tablets to include the treatment of pediatric patients one year of age and older with newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) in combination with chemotherapy. (businesswire.com)
- The efficacy of Sprycel tablets in combination with chemotherapy was evaluated in a single cohort of the Phase 2, multicenter, single-arm CA180-372 study, which included 78 pediatric patients with newly diagnosed B-cell precursor Ph+ ALL. (businesswire.com)
- This randomized phase II / III trial studies how well combination chemotherapy with or without rituximab works in treating younger patients with stage III-IV non-Hodgkin lymphoma or B-cell acute leukemia. (cancer.gov)
- It is not yet known whether combination chemotherapy together with rituximab is more effective in treating patients with non-Hodgkin lymphoma or B-cell acute leukemia. (cancer.gov)
- Risk-directed therapy included recommending allogeneic hematopoietic stem cell transplantation (allo-HSCT) for high-risk patients and chemotherapy/autologous-HSCT (auto-HSCT) for low-risk patients. (bloodjournal.org)
- Among 116 eligible patients, MRD status after the second consolidation rather than induction or first consolidation could discriminate high-risk relapse patients ( P = .001). (bloodjournal.org)
- disease-free survival [DFS]: 61.7% vs 19.6%, P = .001), whereas chemotherapy/auto-HSCT achieved a low relapse rate (5.3%) and high DFS (94.7%) for low-risk patients. (bloodjournal.org)
- This phase II/III trial studies how well daunorubicin and cytarabine with or without uproleselan works in treating older adult patients with acute myeloid leukemia receiving intensive induction chemotherapy. (centerwatch.com)
- Describe the frequency and severity of adverse events for patients for each chemotherapy regimen. (centerwatch.com)
- CONSOLIDATION: Patients receive cytarabine IV over 3 hours on days 1-5. (centerwatch.com)
- CONSOLIDATION: Patients who achieve a CR or CRi receive uproleselan IV QD on day 1 and every 12 hours on days 2-8 and cytarabine IV over 3 hours on days 2-6. (centerwatch.com)
- This portion of the treatment is less toxic and is usually much easier to tolerate then the induction and consolidation phases.Most patients will receive oral doses of mercaptopuine (6-MP) every evening and weekly oral methetrexate. (caringbridge.org)
- The patients without progression after induction chemotherapy received apatinib 250 mg per day until disease progression or unacceptable toxicity occurred. (springer.com)
- 2002 ). Patients with lower pretreatment circulating VEGF levels were more likely to respond to chemotherapy compared to those with higher levels of VEGF (Salven et al. (springer.com)
- Patients who have a rapid reduction in the leukemic cells in the bone marrow within 7-14 days following multiagent chemotherapy have a better prognosis. (pediatriconcall.com)
- Systemic chemotherapy is recommended in patients with inguinal lymph node metastases. (medscape.com)
- The results of our study suggest that consolidation RT in patients with advanced-stage HD with initial bulky disease who had postchemotherapy radiologic CR or PR with metabolic CR improved the DFS. (dovepress.com)
- PATIENTS AND METHODS: A total of 287 children with HR-ALL were randomly assigned to intensive chemotherapy regimens (New York I [NY I]or NY II) as part of the Children's Cancer Group (CCG)-1901 protocol. (uptodate.com)
- Patients were randomly assigned to receive G-CSF (5 microg/kg/day) during either induction or initial consolidation. (uptodate.com)
- PURPOSE: This phase II trial is studying how well giving combination chemotherapy works in treating patients with acute promyelocytic leukemia. (ichgcp.net)
- Patients are evaluated between days 60-67 and proceed to consolidation therapy. (ichgcp.net)
- Consolidation therapy: Patients receive cytarabine IV continuously on days 1-3, daunorubicin hydrochloride IV on days 1-3, and arsenic trioxide IV over 1-2 hours once daily, 5 days a week, beginning on day 8 and continuing for 6 weeks. (ichgcp.net)
- Due to the resistance to chemotherapy, the malignant stem cell can undergo additional mutations (11) and is destroyed in a small number of patients, even in those who undergo doses of myeloablative chemotherapy or radiation administered for HSCT. (scielo.br)
- Another option may be very high-dose chemotherapy along with a stem cell transplant. (ahealthyme.com)
- In fact, although randomized trials comparing different chemotherapy induction regimens in APL have not been performed, the inclusion of cytarabine in addition to daunorubicin, with or without other chemotherapy agents (eg, thioguanine, etoposide), does not appear to significantly affect disease outcome, 10 nor does it seem to provide better results than those obtained with high-dose daunorubicin 11-14 or idarubicin alone. (bloodjournal.org)
- They need CNS prophylaxis in the form of cranial irradiation (less commonly used now), intrathecal (methotrexate, cytarabine, steroids) and high-dose systemic chemotherapy (methotrexate, cytarabine, L-asparaginase). (news-medical.net)
- Very high dose chemotherapy followed by stem cell transplantation can also be used. (lls.org)
- Consolidation therapy can be accomplished with multiple courses of chemotherapy or high-dose chemotherapy with autologous or allogeneic stem cell transplantation. (texasoncology.com)
- After PBSC harvesting, high-dose chemotherapy of melphalan with auto-PBSCT was performed. (springer.com)
- High-dose therapy with single autologous transplantation versus chemotherapy for newly diagnosed multiple myeloma: a systematic review and meta-analysis of randomized controlled trials. (springer.com)
- Phase I/II study of tandem high-dose chemotherapy with autologous peripheral blood stem cell transplantation for advanced multiple myeloma. (springer.com)
- Consolidation therapy is high-dose treatment and a stem cell transplant. (macmillan.org.uk)
- 2000 ), high-dose chemotherapy (Leyvraz et al. (springer.com)
- This process is called intrathecal chemotherapy. (mskcc.org)
- The same needle can be used to insert medicines to prevent or treat leukemia in the brain or spinal cord (intrathecal chemotherapy). (chop.edu)
- APL rarely spreads to the brain or spinal cord, so intrathecal chemotherapy is usually not needed. (cancer.org)
- If AML does spread to the CNS, it is treated with chemotherapy given directly into the CSF (called intrathecal chemotherapy) and with systemic chemotherapy. (cancer.ca)
- Chemotherapy, usually with methotrexate, is also given into the spinal fluid (known as intrathecal chemo) for at least 4 doses, each separated by a week. (cancer.org)
- If the patient has not had cranial irradiation, intrathecal chemotherapy for CNS prophylaxis is continued in the maintenance phase. (pediatriconcall.com)
- What are common side effects of chemotherapy? (ahealthyme.com)
- The side effects of chemotherapy are different for everyone. (ahealthyme.com)
- We aimed to analyze the clinical and histological effects of chemotherapy in superficial esophageal squamous cell carcinoma (SESCC). (bioportfolio.com)
- Side effects of chemotherapy will depend mainly on the type of drug, the dose, how it's given (by mouth or by vein) and your overall health. (cancer.ca)
- Find out more about chemotherapy and side effects of chemotherapy . (cancer.ca)
- Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow , digestive tract and hair follicles . (wikipedia.org)
- The rationale for the indication of HSCT is based on the fact that this disease is the result of the accumulation of cells produced by extremely rare malignant stem cells, which are capable of self-renewing (9) and resistant to the cytotoxic effects of chemotherapy (10) , resulting in disease relapse. (scielo.br)
- A phase III randomized multi-center study designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. (roswellpark.org)
- About 510 subjects will be randomized in a 1:1 ratio to receive either crenolanib in addition to standard first line treatment of AML (chemotherapy and if eligible, transplantation) (arm A) or midostaurin and standard treatment (arm B). Potentially eligible subjects will be registered and tested for the presence of FLT3 mutation. (roswellpark.org)
- Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. (ox.ac.uk)
- Stem cell transplantation is used to intensify the chemotherapies and radiotherapies as it replaces destroyed stem cells. (news-medical.net)
- It can be risky due to the high intensity chemotherapy or radiation given prior to stem cell transplantation. (news-medical.net)
- A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma: intergroupe francais du myeloma. (springer.com)
- Causes of neutropenia include chemotherapy and bone marrow transplantation. (wikipedia.org)
- Chemotherapy is the use of potent drugs or chemicals, often in combinations or intervals, to kill or damage cancer cells in the body. (lls.org)
- Chemotherapy drugs are often called anticancer agents. (lls.org)
- All chemotherapy drugs interfere with cancer cells' ability to grow or multiply. (lls.org)
- That's why it's essential that the disease be accurately diagnosed: Certain chemotherapy drugs are used only for certain disease cell types. (lls.org)
- Both new chemotherapy drugs and new ways to attack cancer cells continue to emerge as research progresses. (lls.org)
- Many chemotherapy drugs attack cancer cells by interacting with the cancer cell's DNA or RNA (genetic makeup). (lls.org)
- Drugs used in chemotherapy, such as carboplatin and paclitaxel, work in different ways to stop the growth of tumor cells either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (swedish.org)
- Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. (clinicaltrials.gov)
- Its intensity can be reduced by steroids, chemotherapy, proteasome inhibitors, immunomodulatory drugs such as thalidomide or lenalidomide, and stem cell transplants. (newsmaker.com.au)
- Chemotherapy uses anticancer, or cytotoxic, drugs to destroy cancer cells. (cancer.ca)
- Your healthcare team will consider your personal needs to plan the drugs, doses and schedules of chemotherapy. (cancer.ca)
- Some doctors believe it may be related to exposure to certain chemicals, radiation , and even drugs used for chemotherapy . (healthline.com)
- Stem cell transplant and the chemotherapy drugs used in preparation for a stem cell transplant can cause serious side effects, so not everyone can have this treatment. (cancer.ca)
- Chemotherapy is given in 3 phases (induction, consolidation, and maintenance) using many chemo drugs. (cancer.org)
- It is given as 3 phases of chemotherapy (induction, consolidation, and maintenance) using many drugs, and it lasts for about 2 years. (cancer.org)
- Studies are being done to determine whether adding other drugs to chemotherapy might make treatment more effective. (cancer.org)
- Treatment for these lymphomas usually consists of chemotherapy with 4 or more drugs given for about 3 to 6 months. (cancer.org)
- He will get the standard chemotherapy that is treated the same way throughout the country, plus additonal treatment and drugs that are part of this study to further the research to lower the risk of the cancer coming back. (caringbridge.org)
- In this type of treatment, chemotherapy drugs are often injected directly into the fluid that covers the spinal cord. (mayoclinic.org)
- Chemotherapy drugs can also be used in the consolidation and maintenance phases. (mayoclinic.org)
- Chemotherapy is usually given as a combination of drugs, usually given over a period of a week or so. (leukaemia.org.au)
- And I think the reality is, we have better drugs, we do better consolidation, and we do better maintenance now. (onclive.com)
- Chemotherapy may be given with a curative intent (which almost always involves combinations of drugs), or it may aim to prolong life or to reduce symptoms (palliative chemotherapy). (wikipedia.org)
- Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity ). (wikipedia.org)
- Combination chemotherapy involves treating a patient with a number of different drugs simultaneously. (wikipedia.org)
- Conclusions: The intensified treatment paradigm of XELOX concurrent chemoradiation followed by one cycle of consolidation chemotherapy was well tolerated in our cohort and provided a promising long-term oncologic outcome, which warranted further investigation in a randomize trails. (medworm.com)
- Chemotherapy is the main treatment for nearly all people with acute lymphocytic leukemia (AML). (ahealthyme.com)
- If the first treatment with chemotherapy doesn't work, your doctor may advise another type of chemotherapy. (ahealthyme.com)
- If you get chemotherapy, you will likely meet with a hematologist/oncologist before treatment starts. (ahealthyme.com)
- This treatment involves having chemotherapy through a central venous access device (CVAD). (eviq.org.au)
- Potential treatment opinions after first-line chemotherapy for advanced NSCLC: maintenance treatment or early second-line? (naver.com)
- Treatment for AML carried out in two stages - the initial stage or induction stage to kill the leukemia cells of the bone marrow and the consolidation stage to kill any remaining leukemia cells that may be present in the body. (news-medical.net)
- Treatment involves receiving regular injections of chemotherapy medication. (news-medical.net)
- The consolidation phase of treatment lasts several months. (news-medical.net)
- Except for those with mature-B ALL who receive short-term intensive chemotherapy, treatment for ALL typically consists of two phases of induction and consolidation. (news-medical.net)
- The following is a general overview of the treatment of the consolidation treatment options for acute myeloid leukemia. (texasoncology.com)
- The purpose of the study was to test a null hypothesis that a combined modality treatment of esophageal cancer with neoadjuvant chemotherapy or chemoradiotherapy is equivalent to surgery a. (bioportfolio.com)
- Determining the best treatment option for consolidation is not easy and each approach has its own pros and cons. (news-medical.net)
- The second stage of treatment, called "consolidation," is undertaken with the goal to cure the disease. (bio-medicine.org)
- Most people stay in the hospital during treatment because chemotherapy also kills healthy cells, raising your risk for infection and abnormal bleeding. (healthline.com)
- Treatment is usually given in 2 phases, called induction and consolidation. (cancer.ca)
- The main treatment for AML is chemotherapy. (cancer.ca)
- We concluded that MRD status after the second consolidation may be the best timing for treatment choice. (bloodjournal.org)
- In general, all children with non-Hodgkin lymphoma (NHL) are treated with chemotherapy (chemo), but the exact treatment differs depending on the type and stage of the lymphoma. (cancer.org)
- Therefore, chemotherapy is an important part of treatment for all children with NHL. (cancer.org)
- Chemotherapy (chemo) is the main form of treatment for these lymphomas. (cancer.org)
- Studies are now being done to determine whether adding a monoclonal antibody such as rituximab to chemotherapy will make treatment more effective. (cancer.org)
- He received a week off from chemotherapy before he started his next phase of treatment so he could increase his blood counts and strengthen his immune system. (caringbridge.org)
- On Thursday, July 12 he started the Consolidation phase of his treatment. (caringbridge.org)
- Chemotherapy is the main form of treatment for AML. (leukaemia.org.au)
- 1991 ). The main cause of treatment failure is rapid recurrence and resistance to second-line chemotherapy (Schiller et al. (springer.com)
- Induction chemotherapy is the first line treatment of cancer with a chemotherapeutic drug. (wikipedia.org)
- These data indicate that a significant reduction in toxicity might be obtained in APL using a less intensive consolidation without apparently compromising the antileukemic effect. (bloodjournal.org)
- Allogeneic stem cell transplant involves the transfer of stem cells from a healthy donor to the patient's body after intensive radiation or chemotherapy. (news-medical.net)
- The key objectives of this intensive chemotherapy are to kill as many leukemic cells as possible and to deactivate the immune system and thus reduce the possibility of a graft rejection. (news-medical.net)
- Older adults in poor health may not tolerate intensive chemotherapy. (news-medical.net)
- Shorter and less intensive treatments, such as the chemotherapy combinations called CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) and COMP (cyclophosphamide, vincristine, methotrexate, and prednisone) have also been used. (cancer.org)
- Children with more advanced lymphomas need more intensive chemotherapy. (cancer.org)
- You may get higher doses of chemotherapy medicines for several days. (ahealthyme.com)
- A stem cell transplant that includes lower doses of chemotherapy and/or radiation than is standard. (bcm.edu)
- A bone marrow transplant begins with high doses of chemotherapy or radiation to destroy any leukemia-producing bone marrow. (mayoclinic.org)
- The purpose of this study is to determine the efficacy and safety of consolidation chemotherapy with paclitaxel plus cisplatin (2 cycles per 3 weeks) following radical hysterectomy and adjuvant chemoradiation (2 cycles per 4 weeks) for high risk early stage cervical cancer. (clinicaltrials.gov)
- They will be randomized and assigned to undergo TME followed by 8 cycles of adjuvant chemotherapy (control arm) or receive 3 cycles of consolidation chemotherapy before TME, and receive 5 cycles of adjuvant chemotherapy (experimental arm). (beds.ac.uk)
- Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute lymphoblastic leukemia. (haematologica.org)
- BACKGROUND AND OBJECTIVES: To evaluate the impact of early and delayed consolidation chemotherapy on the outcome of children with acute lymphoblastic leukemia (ALL) stratified according to risk groups. (haematologica.org)
- If there are still leukemia cells in your bone marrow, you may have a second course of chemotherapy. (ahealthyme.com)
- The closer together induction and consolidation are given, the lesser the chance of leukemia recurrence. (news-medical.net)
- Further trials with a larger patient population are warranted in order to evaluate the potential role of consolidation chemotherapy. (beds.ac.uk)
- Chemotherapy medicines are designed to attack and kill cells that divide quickly, including cancer cells. (ahealthyme.com)
- Neoadjuvant chemotherapy in local-regionally advanced nasopharyngeal carcinoma: A National Cancer Database analysis. (bioportfolio.com)
- A higher percentage of radical resection is reported in studies using neoadjuvant chemotherapy followed by surgery versus surgery alone for esophageal cancer. (bioportfolio.com)
- Chemotherapy for other forms of cancer. (encyclopedia.com)
- Chemotherapy may cause side effects because it can damage healthy cells as it kills cancer cells. (cancer.ca)
- Chemotherapy refers to medicines that help fight cancer. (chop.edu)
- To evaluate the efficacy of maintenance apatinib after chemotherapy for extensive-stage (ED) small-cell lung cancer (SCLC). (springer.com)
- A woman being treated with docetaxel chemotherapy for breast cancer . (wikipedia.org)
- Chemotherapy is one of the major categories of the medical discipline specifically devoted to pharmacotherapy for cancer , which is called medical oncology . (wikipedia.org)
- Giving more than one drug (combination chemotherapy) may kill more cancer cells. (ichgcp.net)
- Discuss cancer chemotherapy with respect to cell kinetics. (arizona.edu)
- Some people with higher-risk disease may be given chemotherapy directly into the fluid that surrounds the spinal cord and brain. (mskcc.org)
- Chemotherapy into the spinal fluid is needed only if the lymphoma is growing around the head or neck. (cancer.org)
- Chemotherapy must also be given into the spinal fluid. (cancer.org)
- He went weekly to Amplatz Children's hospital clinic for Lumbar punctures (spinal taps), chemotherapy, lab work, and possibility of receiving blood and/or platelets. (caringbridge.org)
- This type of stem cell transplant is most commonly used in situations where the patient has underlying conditions that might make the chemotherapy/radiation excessively toxic to them. (bcm.edu)
- As I recall, there was a slight advantage to tandem transplant, 4 months, and to consolidation, maybe 3 or 4 months-but nothing spectacular. (onclive.com)
- My answer would be, if you use chemotherapy as part of your induction, you probably need a second transplant. (onclive.com)