Drug treatment designed to further diminish the disease toward complete remission following INDUCTION CHEMOTHERAPY. It helps to consolidate the gains during induction chemotherapy and may be followed by MAINTENANCE CHEMOTHERAPY.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
A pyrimidine nucleoside analog that is used mainly in the treatment of leukemia, especially acute non-lymphoblastic leukemia. Cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. Its actions are specific for the S phase of the cell cycle. It also has antiviral and immunosuppressant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p472)
A very toxic anthracycline aminoglycoside antineoplastic isolated from Streptomyces peucetius and others, used in treatment of LEUKEMIA and other NEOPLASMS.
Therapeutic act or process that initiates a response to a complete or partial remission level.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA.
An aminoacridine derivative that intercalates into DNA and is used as an antineoplastic agent.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
An anthracenedione-derived antineoplastic agent.
Form of leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors (MYELOID PROGENITOR CELLS) in the bone marrow and other sites.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Transplantation of an individual's own tissue from one site to another site.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias.
An acute myeloid leukemia in which abnormal PROMYELOCYTES predominate. It is frequently associated with DISSEMINATED INTRAVASCULAR COAGULATION.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
A decrease in the number of NEUTROPHILS found in the blood.
Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Disease having a short and relatively severe course.
Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The persistence to perform a learned behavior (facts or experiences) after an interval has elapsed in which there has been no performance or practice of the behavior.
The affective response to an actual current external danger which subsides with the elimination of the threatening condition.
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Initial drug treatment designed to bring about REMISSION INDUCTION. It is typically a short-term and high-dose drug treatment that is followed by CONSOLIDATION CHEMOTHERAPY and then MAINTENANCE CHEMOTHERAPY.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Tumors or cancer of the human BREAST.
Elements of limited time intervals, contributing to particular results or situations.
Learning that takes place when a conditioned stimulus is paired with an unconditioned stimulus.
A response to a cue that is instrumental in avoiding a noxious experience.
Remembrance of information from 3 or more years previously.
Tumors or cancer of the LUNG.
An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
A readily reversible suspension of sensorimotor interaction with the environment, usually associated with recumbency and immobility.
Relatively permanent change in behavior that is the result of past experience or practice. The concept includes the acquisition of knowledge.
An organoplatinum compound that possesses antineoplastic activity.
A general term referring to the learning of some particular response.
Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.
A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.
Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.
The principle that items experienced together enter into a connection, so that one tends to reinstate the other.
An induced response to threatening stimuli characterized by the cessation of body movements, except for those that are involved with BREATHING, and the maintenance of an immobile POSTURE.
Antimetabolites that are useful in cancer chemotherapy.
Positional isomer of CYCLOPHOSPHAMIDE which is active as an alkylating agent and an immunosuppressive agent.
A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.
The process whereby a representation of past experience is elicited.
Organic compounds that have a tetrahydronaphthacenedione ring structure attached by a glycosidic linkage to the amino sugar daunosamine.
Induction of a stress reaction in experimental subjects by means of an electrical shock; applies to either convulsive or non-convulsive states.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
Bone lengthening by gradual mechanical distraction. An external fixation device produces the distraction across the bone plate. The technique was originally applied to long bones but in recent years the method has been adapted for use with mandibular implants in maxillofacial surgery.
The combining of administrative and organizational resources of two or more health care facilities.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
A class of drugs that differs from other alkylating agents used clinically in that they are monofunctional and thus unable to cross-link cellular macromolecules. Among their common properties are a requirement for metabolic activation to intermediates with antitumor efficacy and the presence in their chemical structures of N-methyl groups, that after metabolism, can covalently modify cellular DNA. The precise mechanisms by which each of these drugs acts to kill tumor cells are not completely understood. (From AMA, Drug Evaluations Annual, 1994, p2026)
Organic compounds which contain platinum as an integral part of the molecule.
Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
The procedure of presenting the conditioned stimulus without REINFORCEMENT to an organism previously conditioned. It refers also to the diminution of a conditioned response resulting from this procedure.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
An antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Learning the correct route through a maze to obtain reinforcement. It is used for human or animal populations. (Thesaurus of Psychological Index Terms, 6th ed)
The relationship between the dose of an administered drug and the response of the organism to the drug.
The return of a sign, symptom, or disease after a remission.
Neoplasm drug therapy involving an extracorporeal circuit with temporary exclusion of the tumor-bearing area from the general circulation during which high concentrations of the drug are perfused to the isolated part.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)
Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
A hydrolase enzyme that converts L-asparagine and water to L-aspartate and NH3. EC 3.5.1.1.
Vinblastine derivative with antineoplastic activity against CANCER. Major side effects are myelosuppression and neurotoxicity. Vindesine is used extensively in chemotherapy protocols (ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS).
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
Treatment designed to help prevent a relapse of a disease following the successful primary treatments (INDUCTION CHEMOTHERAPY and CONSOLIDATION CHEMOTHERAPY) with a long-term low-dose drug therapy.
The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.
Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564)
The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.
The forcible expulsion of the contents of the STOMACH through the MOUTH.
A malignant epithelial tumor with a glandular organization.
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
The knowledge or perception that someone or something present has been previously encountered.
Performance of complex motor acts.
Tumors or cancer located in bone tissue or specific BONES.
The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.
A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Antibodies obtained from a single clone of cells grown in mice or rats.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Pathologic partial or complete loss of the ability to recall past experiences (AMNESIA, RETROGRADE) or to form new memories (AMNESIA, ANTEROGRADE). This condition may be of organic or psychologic origin. Organic forms of amnesia are usually associated with dysfunction of the DIENCEPHALON or HIPPOCAMPUS. (From Adams et al., Principles of Neurology, 6th ed, pp426-7)
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.
A hexamethyl-2,4,6-triamine derivative of 1,3,5-triazine.
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
Periods of sleep manifested by changes in EEG activity and certain behavioral correlates; includes Stage 1: sleep onset, drowsy sleep; Stage 2: light sleep; Stages 3 and 4: delta sleep, light sleep, deep sleep, telencephalic sleep.
Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ layers of the EMBRYO, MAMMALIAN. The concept does not refer to neoplasms located in the gonads or present in an embryo or FETUS.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
The observable response an animal makes to any situation.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
An alkylating agent of value against both hematologic malignancies and solid tumors.
Reactions of an individual or groups of individuals with relation to the immediate surrounding area including the animate or inanimate objects within that area.
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Antibodies produced by a single clone of cells.
The exposure of the head to roentgen rays or other forms of radioactivity for therapeutic or preventive purposes.
Inorganic compounds which contain platinum as the central atom.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
Regional infusion of drugs via an arterial catheter. Often a pump is used to impel the drug through the catheter. Used in therapy of cancer, upper gastrointestinal hemorrhage, infection, and peripheral vascular disease.
A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Drugs used to prevent NAUSEA or VOMITING.
A general term for various neoplastic diseases of the lymphoid tissue.
An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.
A subspecialty of internal medicine concerned with the study of neoplasms.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Disturbances in registering an impression, in the retention of an acquired impression, or in the recall of an impression. Memory impairments are associated with DEMENTIA; CRANIOCEREBRAL TRAUMA; ENCEPHALITIS; ALCOHOLISM (see also ALCOHOL AMNESTIC DISORDER); SCHIZOPHRENIA; and other conditions.
Treatment that combines chemotherapy with radiotherapy.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
A series of thoughts, images, or emotions occurring during sleep which are dissociated from the usual stream of consciousness of the waking state.
Tumors or cancer of the LIVER.
Tumors or cancer of the PERITONEUM.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Tumors or cancer of the STOMACH.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Congener of FLUOROURACIL with comparable antineoplastic action. It has been suggested especially for the treatment of breast neoplasms.
Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)
X-ray visualization of the chest and organs of the thoracic cavity. It is not restricted to visualization of the lungs.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
A subnormal level of BLOOD PLATELETS.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
The tendency to explore or investigate a novel environment. It is considered a motivation not clearly distinguishable from curiosity.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
A malignant neoplasm of the germinal tissue of the GONADS; MEDIASTINUM; or pineal region. Germinomas are uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular eosinophilic-staining cytoplasm. (Stedman, 265th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1642-3)
A cell line derived from cultured tumor cells.
Those federal and state laws, and their enforcement, that protect trade and commerce from unlawful restraints and monopolies or unfair business practices.
The state of being deprived of sleep under experimental conditions, due to life events, or from a wide variety of pathophysiologic causes such as medication effect, chronic illness, psychiatric illness, or sleep disorder.
A stage of sleep characterized by rapid movements of the eye and low voltage fast pattern EEG. It is usually associated with dreaming.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
Benign and malignant neoplastic processes that arise from or secondarily involve the brain, spinal cord, or meninges.
Type of declarative memory, consisting of personal memory in contrast to general knowledge.
Tumors or cancer of the MEDIASTINUM.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. The pattern is predominantly diffuse. Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation.
An anti-inflammatory 9-fluoro-glucocorticoid.
Transplant comprised of an individual's own tissue, transferred from one part of the body to another.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.
The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Loss of the ability to recall information that had been previously encoded in memory prior to a specified or approximate point in time. This process may be organic or psychogenic in origin. Organic forms may be associated with CRANIOCEREBRAL TRAUMA; CEREBROVASCULAR ACCIDENTS; SEIZURES; DEMENTIA; and a wide variety of other conditions that impair cerebral function. (From Adams et al., Principles of Neurology, 6th ed, pp426-9)
Cyclic hydrocarbons that contain multiple rings and share one or more atoms.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
Malignant lymphoma in which the lymphomatous cells are clustered into identifiable nodules within the LYMPH NODES. The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES.
Abnormally high temperature intentionally induced in living things regionally or whole body. It is most often induced by radiation (heat waves, infra-red), ultrasound, or drugs.
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
The injection of very small amounts of fluid, often with the aid of a microscope and microsyringes.
Platinum. A heavy, soft, whitish metal, resembling tin, atomic number 78, atomic weight 195.09, symbol Pt. (From Dorland, 28th ed) It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as "alutiae".
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Learning that is manifested in the ability to respond differentially to various stimuli.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Increase in the longest dimension of a bone to correct anatomical deficiencies, congenital, traumatic, or as a result of disease. The lengthening is not restricted to long bones. The usual surgical methods are internal fixation and distraction.
A professional society in the United States whose membership is composed of hospitals.
The effort of two or more parties to secure the business of a third party by offering, usually under fair or equitable rules of business practice, the most favorable terms.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
Works about comparative studies to verify the effectiveness of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques determined in phase II studies. During these trials, patients are monitored closely by physicians to identify any adverse reactions from long-term use. These studies are performed on groups of patients large enough to identify clinically significant responses and usually last about three years. This concept includes phase III studies conducted in both the U.S. and in other countries.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Works about studies that are usually controlled to assess the effectiveness and dosage (if appropriate) of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques. These studies are performed on several hundred volunteers, including a limited number of patients with the target disease or disorder, and last about two years. This concept includes phase II studies conducted in both the U.S. and in other countries.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.

Treatment of acute promyelocytic leukemia for older patients. (1/34)

Acute promyelocytic leukemia (APL) represents a remarkable disease in which leukemogenesis is driven by the PML-RARalpha oncogene and for which targeted treatment with all-trans retinoic acid (ATRA)-based therapy allows substantial chance of cure. APL is seen in a small subset of older patients, with age representing one of the most important prognostic factors for outcome of treatment. Unlike other acute leukemias, the inferior outcomes for APL in older patients relates less to changes in disease biology and more to the increased toxicity of ATRA and the chemotherapy combination regimens used to induce hematologic and molecular responses. Risk-adapted strategies that use less-toxic agents, such as arsenic trioxide, allow treatment of older patients, with greater efficiency and better chances of cure.  (+info)

High-dose chemotherapy consolidation for chemosensitive advanced soft tissue sarcoma patients: an open-label, randomized controlled trial. (2/34)

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Results of the APML3 trial incorporating all-trans-retinoic acid and idarubicin in both induction and consolidation as initial therapy for patients with acute promyelocytic leukemia. (3/34)

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Identifying clinical improvement in consolidation single-arm phase 2 trials in patients with ovarian cancer in second or greater clinical remission. (4/34)

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Curing all patients with acute promyelocytic leukemia: are we there yet? (5/34)

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Updated survival and outcomes for older adults with inoperable stage III non-small-cell lung cancer treated with cisplatin, etoposide, and concurrent chest radiation with or without consolidation docetaxel: analysis of a phase III trial from the Hoosier Oncology Group (HOG) and US Oncology. (6/34)

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Immunochemotherapy with intensive consolidation for primary CNS lymphoma: a pilot study and prognostic assessment by diffusion-weighted MRI. (7/34)

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Predictors of prolonged survival after allogeneic hematopoietic stem cell transplantation for multiple myeloma. (8/34)

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The goal of this clinical research study is to learn if clofarabine when given in combination with cytarabine can help to control myelodysplastic syndrome (MDS) after the disease could not be controlled with standard therapy. The safety of this treatment will also be studied. Clofarabine is designed to interfere with the growth and development of cancer cells. Cytarabine is designed to insert itself into DNA (the genetic material of cells) of cancer cells and stop the DNA from repairing itself.
Define consolidation chemotherapy. consolidation chemotherapy synonyms, consolidation chemotherapy pronunciation, consolidation chemotherapy translation, English dictionary definition of consolidation chemotherapy. n. 1. The treatment of cancer using specific chemical agents or drugs that are selectively destructive to malignant cells and tissues. 2. The treatment of...
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Key players in the global hyperconverged integrated systems market include Nutanix, Pivot3, Hewlett Packard Enterprise, Scale Computing, VMware, Inc.
The Japanese Ministry of Health, Labour and Welfare has approved brentuximab vedotin (Adcetris) in combination with doxorubicin, vinblastine, and dacarbazine as a frontline treatment option for CD30-positive Hodgkin lymphoma (HL). The approval was based on the phase 3 ECHELON-1 trial. Result from ECHELON-1 were presented at the 2017 ASH Annual Meeting and simultaneously published in The New England Journal of Medicine. In this trial, researchers compared brentuximab vedotin plus doxorubicin, vinblastine, and dacarbazine (A+AVD) to doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) as frontline treatment for 1334 patients with advanced HL. The primary endpoint was modified progression-free survival (PFS), which was defined as time to progression, death, or evidence of non-complete response after completion of frontline therapy followed by subsequent anticancer therapy. According to an independent review committee, A+AVD provided a significant improvement in modified PFS compared to ABVD. ...
Richard W. Joseph, MD, notes that current treatment guidelines for melanoma recommend anti-PD-1 agents as front line therapy and discusses payer coverage for first-line use of these agents.
Introduction to consolidation concept - The odometer test -Compressibility characteristics - The e-log10бv carve and casagrandepreconsoldation pressure -Teraghi theory for 1-D consolidation - Degree of consolidation - Consolidation settlement and secondary compression - coefficient of consolidation by Taylo and Casagrande method - ...
This morning began a whole new phase of this adventure: consolidation chemotherapy, on an outpatient basis (yay!). We arrived dutifully at 8:15 for our 8:30 appointment. A little before 9:00 a nurse came and got me and took me to the room where they draw blood samples, then led me back to the waiting area. Some undetermined amount of time later-felt like forever, was probably something like 15 or 20 minutes-another nurse came and ushered me into what I think they call the Infusion Room-a large, open room with hardwood floors (!) and 16 big soft leather reclining chairs. She sat me down, and very quickly realized we hadnt received even rudimentary patient education in what was about to happen; so, patiently, she described the process, explained the potential side-effects (ugh), etc., etc. She gave me an anti-nausea drug, then, at about 10:30, finally started the chemo going. Anna sat in the next chair with her laptop, working hard on a major presentation in between calls to our nutritionist and ...
The availability of effective TKIs for patients with metastatic NSCLC with targetable oncogenes such as EGFR, ALK, ROS1, and BRAF has transformed the treatment ...
Hello and welcome back. If you found this idea helpful, please leave a like. EURUSD is in an area where we could go into consolidation. It was unable to go higher last week. From a directional standpoint, if I were to choose a side, I see lower prices targeting the lows at 1.1685 and if we run hard, 1.1615. It is very hard for me to gauge anything due to the current environment we are in right now with the U.S election and so forth. Overall, if I were to choose a side, I see this going lower. …
A process of formation consolidation is provided wherein the formation is heated and a substance which acts as a bonding agent when heated is then flowed into the formation. To insure a clean bonding surface, in situ combustion may be initiated in the area to be consolidated prior to injection of the bonding substance. Heat may be supplied to the formation after injection of the bonding substance.
The consolidation with 2.4 cm cavitation is also seen in approximately one third of patients with pulmonary NTM. (2,3,4) Also seen on the inferior aspect of the
The success of data center consolidation initiatives will be determined more by culture and management issues than technology, according to federal managers and industry experts speaking at a recent conference on data center optimization.
PRIMARY OBJECTIVES:. I. To evaluate the safety, tolerability, and pharmacokinetic (PK) and pharmacodynamic (PD) profile of AMG 386 (trebananib) when administered alone and in combination with low-dose cytarabine in adult patients with: untreated AML considered ineligible for standard induction chemotherapy; refractory and/or relapsed AML following at least one cycle of prior therapy who are not currently eligible for stem cell transplantation.. SECONDARY OBJECTIVES:. I. To evaluate clinical responses in AML patients following AMG 386 therapy alone or in combination with low-dose cytarabine therapy.. II. To characterize the biological changes occurring in AML patients treated with AMG 386 alone or in combination with low-dose cytarabine, specifically: alteration in angiopoietin (Ang)1, Ang2, Tie2, vascular endothelial growth factor (VEGF), and VEGF receptor (VEGFR) expression; changes in bone marrow vascularization and hypoxia; changes in gene and/or micro ribonucleic acid (microRNA) expression; ...
Clinical trial for childhood ALL | leukemia , Hyper-CVAD Regimen in Sequential Combination With Blinatumomab as Frontline Therapy for Adults With B-Cell Lineage Acute Lymphocytic Leukemia
This study consists of three portions: The first portion- Phase 1, or dose-escalation portion, that will evaluate the safety and pharmacokinetic profile of
with trilineage dysplasia (AML-TD). High dose (HD) lenalidomide (50 mg) has activity as frontline therapy in elderly AML but ... included patients with RR HR-MDS or AML-TD at 2 doses of lenalidomide (15 or 50 mg) on days 1-28 of 42-day cycles. The primary endpoint .... Research Article last updated 11/02/2016 - 9:17am.. ...
Physician reviewed clofarabine patient information - includes clofarabine description, dosage and directions.Print coupons and compare prices.
An era of consolidation is on the cards for local media, after the industry watchdog Ofcom proposed a relaxation of ownership rules.The regulator has
The decision to move from one platform to another; or to unify an office full of IT equipment can be challenging as well as financially draining on your business. Our Migration/Consolidation solutions offer you a complete package which takes the burden away from you.
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Market and regulatory factors have unleashed a wave of merger, acquisition, and partnership activity that is changing the delivery of healthcare services.
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In the continuing consolidation in the enterprise content management space, Stellent moves to acquire Optika for $59 million in stock and cash.
This trial will investigate the efficacy and tolerability of clofarabine [Clolar; Genzyme Corporation] and cyclophosphamide [Cytoxan, Neosar] in patients with
TREATMENT WITH LOW-DOSE CYTARABINE IN ELDERLY PATIENTS (AGE 70 YEARS OR OLDER) WITH ACUTE MYELOID LEUKEMIA: A SINGLE INSTITUTION EXPERIENCE
The investigators will prospectively determine whether the relapse-free and overall survival in patients who have cleared their leukemia-associated mutations treated with standard consolidation chemotherapy is superior to what is expected based on historical controls. The investigators will also prospectively determine the relapse-free and overall survival of patients who have not cleared their mutations. Because the relapse rate of patients with persistent mutations is expected to be high, treatment with either standard of care consolidation therapy alone or alloSCT will be permitted, at the discretion of the treating physician. Location: University of Rochester Medical ...
The purpose of this study is to determine the therapeutic efficacy and complications of systemic consolidation therapy with paclitaxel plus carboplatin following primary chemoradiation for locally advanced cervical cancer.
Conclusions: The intensified treatment paradigm of XELOX concurrent chemoradiation followed by one cycle of consolidation chemotherapy was well tolerated in our cohort and provided a promising long-term oncologic outcome, which warranted further investigation in a randomize trails....
Ahead of this months Softworld exhibition, FDs can become preoccupied with seeing their software vendor being gobbled up. Our reporter looks at how to protect finance functions from the ravages of IT consolidation ...
85. Assessment of Foreign Qualifications Act, cf. Consolidation Act No. 74 of 24 January 2003, with the amendments following from Act No. 315 of 30 March 2007, (2007).. ...
After a median follow-up of 4 years, the actuarial risk of leukemic relapse was considerably lower in the transplant group than in the group treated with consolidation chemotherapy (32% +/- 26% v 60% +/- 14%; P = .05). Treatment-related mortality, however, was much higher in the group treated with BMT (32% v 6%, P = .002). The actuarial disease-free survival at 5 years was not significantly different for the two groups (45% +/- 24% v 38% +/- 14%). Conclusions: ...
Gemtuzumab ozogamicin was withdrawn from the market after being evaluated in combination with chemotherapy in the frontline treatment of patients aged 18 to 60 years with acute myeloid leukaemia (AML). More-recent randomised trials demonstrate that low doses of gemtuzumab added to cytarabine and anthracycline-based chemotherapy benefit patients with better-risk AML. This article was first published [more]
Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥65 years) patients in the phase 3 AZA-AML-001 trial had newly diagnosed AML-MRC. We compared clinical outcomes for patients with AML-MRC treated with azacitidine or conventional care regimens (CCR; induction chemotherapy, low-dose cytarabine, or supportive care only) overall and within patient subgroups defined by cytogenetic risk (intermediate or poor) and age (65-74 years or ≥75 years). The same analyses were used to compare azacitidine with low-dose cytarabine in patients who had been preselected to low-dose cytarabine before they were randomized to receive azacitidine or CCR (ie, low-dose cytarabine). Median overall survival was significantly prolonged with azacitidine (n = 129) versus CCR (n
Prospective, multicenter, uncontrolled cohort study to analyze the efficacy of a risk adapted treatment strategy, including gemtuzumab ozogamicin (GO) d
BACKGROUND: Treatment-free remission in chronic myeloid leukaemia-ie, achievement of a sustained deep molecular response leading to discontinuation of BCR-ABL1 tyrosine kinase inhibitor (TKI) therapy-has become a potential aim of therapy. Highly priced second-generation TKIs might offer deep molecular response status more quickly and for more patients than imatinib; however, with the availability and lower cost of generic imatinib, the value of second-generation TKIs as frontline therapy for this particular treatment endpoint remains unknown. We aimed to assess the potential value of second-generation TKIs used as frontline therapy in patients with chronic myeloid leukaemia in chronic phase in relation to the probability of achieving sustained deep molecular responses compared with generic imatinib, and the associated cost of each modality. METHODS: We used a decision analytic model to consider the value of different TKI approaches from the payers perspective. The proportion of patients ...
With the improvement of treatments and the heterogeneity of responses, it has become evident that prognosis factors should be now defined to help in therapeutic decision making. Classification systems have evolved to predict outcomes in MCL. Blastoid histology, high expression of Ki-67, and CDKN2A/TP53 deletions have been clearly associated with unfavorable prognosis.9-12 Additionally, recently developed is an MCL-specific clinical prognostic tool-the Mantle Cell International Prognostic Index (MIPI)- based on 4 independent prognostic factors: age, performance status, lactate dehydrogenase, and leukocyte count.13,14 The MIPI separates patients with MCL into 3 risk groups: high (including patients relapsing during the year after end of treatment); intermediate (including patients with an incidence of relapse of 10% to 15% per year); and low (including almost 30% of patients with a complete response [CR] lasting 5 years or more).7,15 The proliferation index Ki-67 was then incorporated into the ...
INDUCTION/RE-INDUCTIONI: Patients receive vorinostat PO TID on days 1-3, high-dose cytarabine IV continuously on days 4-7, and idarubicin IV over 15 minutes on days 4-6. Patients with residual blasts may receive re-induction treatment beginning on day 28. Patients achieving CR or CRi may proceed to allogeneic HSCT or to consolidation therapy.. CONSOLIDATION: Patients receive vorinostat PO TID on days 1-3, cytarabine IV continuously on days 4-6, and idarubicin IV over 15 minutes on days 4-5.. TRANSPLANT: Patients may undergo an allogeneic transplant after induction therapy or consolidation therapy. (Permanently closed to accrual, effective 6/2/2015) Patients previously randomized to Arm III may continue treatment with or without vorinostat. ...
At data cut-off, patients who achieved a partial response survived a median of 14.4 months, while those who achieved complete response attained 19.7 months. Further data collection on these patients will be included in future studies. Overall survival for this group nearly tripled compared to previous studies evaluating other treatments in this patient population, up from 3.3 months to 9.3 months.. In this early study, the survival benefit of nine months in patients with advanced relapsed or treatment-resistant disease is very significant, noted Dr. Stein. We are further encouraged to see that there we so few serious adverse events for these patients.. Adverse events included increased bilirubin, nausea, IDH-DS (a buildup of fluid in the body and/or lungs), and a proliferation of white blood cells known as leukocytosis. Two participants who experienced IDH-DS died in the course of treatment.. Further trials to assess enasidenib as a frontline therapy, in combination with standard AML ...
(KudoZ) English to German translation of Audit Consolidation Questionnaire: Fragebogen zur Prüfung des Konzernabschlusses [Accounting (Bus/Financial)].
In the first regime (surpluses/consolidation) the average growth rate is m1 = -1.006% per month while in the second regime (deficits/expansion) the average growth rate is m2 = 0.072%. In other terms, the estimates associate state 1 (consolidation) with a 1% decrease in the primary deficits and state 2 (expansion) with a 0.07% increase in the primary deficits. The estimates also show that each regime is highy persistent. The probability that a consolidation will be followed by another month of consolidation is p11 = 0.983, so that this regime will persist on average for 1/(1-p11) = 59 months. The probability that an expansion will be followed by another month of expansion is p22 = 0.983, and this regime will persist on average for 1/(1-p22) = 42 months. In other terms, these probabilities indicate that if the system is in either state 1 or state 2, it is likely to stay in that state. The top panel of figure 1 plots the primary deficit in Brazil in percentage of GDP. The bottom panel plots the ...
When we breathe in, the inhaled air enters the trachea, the branches, and through progressively smaller airways reaches the alveoli - microscopic bubbles, where ...
The USD/JPY made a diving board pattern straight from 111.70 zone and it is consolidating now at 38.2 of the previous swing low. The price is supported by 38.2, D L3, W H4 and double bottom within 112.30-40 zone.
Joe Terranova says consolidation and M&A in the space is the reason to own these cyber-security stocks. Click here for details.
Surgery remains a critical intervention in the care of ovarian cancer patients. The three goals of surgery are establishing the diagnosis, determining the extent or stage of disease, and removing the maximal amount of tumor possible. As noted above, the new optimal has become cytoreduction to no gross disease. Staging is critical in patients who have disease apparently confined to the ovary as microscopic involvement of the lymph nodes, omentum, and other surfaces occurs in up to one third of patients.. The preferred route of frontline therapy has seen continued debate. Intraperitoneal therapy, despite three randomized positive trials that showed significant survival advantages in optimally cytoreduced patients, continues to be underutilized throughout the world. The Japanese Gynecologic Oncology Group (GOG) is conducting a validating randomized trial for intraperitoneal therapy.. Likewise the schedule of frontline therapy continues to evolve. Two GOG trials are attempting to establish the ...
Acute myeloid leukaemia (AML) is a term used to represent a heterogeneous group of diseases resulting from a malignant change in the haematopoietic stem cells. In the USA, the overall incidence rate and the death rate are 3.6 and 2.8 per 100 000 people per year, respectively. The incidence increases with age, with 40% of cases occurring in adults aged below 60 years and more than 50% in patients aged 60 years and above. Overall, the 5-year survival rate for adults is 23.4%.1 Complete remission (CR) was achieved in 35%-40% of adult patients aged 60 years or younger and 5%-15% among patients older than 60 years of age.2 Mortality in patients with AML can result from treatment-related causes, relapse or primary refractoriness. The mortality rate is approximately 50% in patients aged 60 years or younger and about 80% in patients aged 60 years and above.3 4. Prognostic factors can be subdivided into two categories: patient-associated factors and disease-related factors. Patient-associated factors, ...
Looking for online definition of clofarabine in the Medical Dictionary? clofarabine explanation free. What is clofarabine? Meaning of clofarabine medical term. What does clofarabine mean?
The study recruited MCL patients older than 65 years from 29 Italian centers, totaling 57 patients all of whom received at least two cycles of treatment.
The mainstay of treatment for leukemia is chemotherapy. Cytotoxic agents are introduced into the body which affect rapidly dividing cells, including cancer cells, resulting in their death. A patient will often undergo several cycles of chemotherapy, administered according to strict protocols. For example, AML is commonly treated with induction chemotherapy (under the 7:3 protocol), and then several cycles of consolidation chemotherapy (under the HiDAC protocol). Chemotherapy is often administered into the spinal cord and brain through intrathecal chemotherapy, particularly for ALL. These affect rapidly dividing cells, including not only leukemia cells, but also normal blood cells, hair, and the mucosal surfaces lining the gastrointestinal tract. This produces a number of side effects, including a pancytopenia (high risk of infection and bleeding), nausea, vomiting, diarrhoea and hair loss. The mortality rate from chemotherapy is approximately 3-4%, the majority of these deaths due to infection. ...
Assistant Professor of Biochemistry and Molecular Genetics and Medicine (Hematology and Oncology). The Ntziachristos laboratory studies the mechanistic aspects of oncogenesis with an emphasis on transcriptional and epigenetic regulation of acute leukemia. Up to 25% of children with Acute Lymphoblastic Leukemia will fail frontline therapy and their prognosis is dismal. Cure rates for patients relapsing on therapy are approximate 20%. While patients with later relapses have a better prognosis, the majority eventually succumbs to the disease (overall cure rate 40 to 50%). Important questions in our laboratory are related to how oncogenes interact with each other and with epigenetic modulators …. ...
Tytu : Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia. ...
TREATMENT WITH LOW-DOSE CYTARABINE IN ELDERLY PATIENTS (AGE 70 YEARS OR OLDER) WITH ACUTE MYELOID LEUKEMIA: A SINGLE INSTITUTION EXPERIENCE
Consolidation therapy with bortezomib/lenalidomide/dexamethasone (VRD) followed by maintenance with lenalidomide until progression or toxicity showed promising results over maintenance alone for patients with transplant-eligible multiple myeloma (NDMM) up to 65 years old, according to a final analysis of the EMN02 trial.
Consistent with other studies, we found that successful consolidations focused on reducing social transfers, which in the American context means entitlements, and also on cuts to the size and pay of the government work force. A 1996 International Monetary Fund study concluded that fiscal consolidation that concentrates on the expenditure side, and especially on transfers and government wages, is more likely to succeed in reducing the public debt ratio than tax-based consolidation. For example, in the U.Ks 1997 consolidation, cuts to transfers made up 32% of expenditure cuts, and cuts to government wages made up 21%. ...
A Moderate Drug Interaction exists between cladribine and clofarabine. View detailed information regarding this drug interaction.
Consolidation, Service and Minimums A vital part of the Royal Advantage is order consolidation. As a high capacity provider of an extremely broad product line, Royal allows customers to maximize order consolidation, resulting in significant savings of both time and money. With low minimums, free freight, same-day shipments, 99% fill rates, and one of the broadest product lines in the industry, buying direct from Royal is more advantageous than ever!. ...
Learn more about cytarabine. We enable science by offering product choice, services, process excellence and our people make it happen.
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As part of its multinational expansion and consolidation, Inteligensa, founded in 1997 by Venanzio Cipollitti and founding member of Intelcav in 2000,
Consolidation treatment often entails a repetition of induction chemotherapy or the intensification chemotherapy with ... induction phase of chemotherapy. Such combination chemotherapy usually offers the benefits of early remission and a lower risk ... Consolidation therapy or intensification therapy to eliminate any remaining leukemia cells. There are many different approaches ... Dental work is recommended before chemotherapy or radiation therapy. Those in remission can be treated per normal. The success ...
Chemotherapy can be used alone or in combination with other therapies. Chemotherapy can be given either as a pill to swallow ... Consolidation/Intensification is used to kill any remaining cells that have the potential to become cancerous. It consists of ... "Chemotherapy to Treat Cancer". National Cancer Institute. 2015-04-29. Retrieved 2018-12-13. "High-dose Chemotherapy and Stem ... Consolidation begins after remission is obtained and is aimed at killing any remaining cancer cells. It will again vary ...
Further studies on the usefulness of radiation, chemotherapy, bone marrow transplantation, and newer non-chemotherapy drugs ... for induction therapy and SMILE for consolidation therapy followed by autologous hemotopoietic stem cell transplantation. Two ... The disease can also occur in those who have had an organ transplantation or chemotherapy treatment or are presumed to have age ... In these cases, surgical removal appears to be the treatment of choice; the role of radiation and chemotherapy here is not well ...
Two other studies that included bortezomib in their chemotherapy regimens likewise found that the addition of autologous stem- ... drug regimen such as borezomib-lenalidomide-dexamethasone followed by autologous stem-cell transplantion and consolidation/ ... In one study, patients receiving intensive chemotherapy plus autologous stem-cell transplantation had a median survival of 34 ... months while those receiving chemotherapy alone had a median survival of 11 months. ...
... pulmonary consolidation, a mass, or a nodule". Pathologically, a cavity is "usually produced by the expulsion or drainage of a ... if a lung cancer develops cavitation after chemotherapy and radiofrequency ablation, that indicates a good response to ...
... in combination with chemotherapy. The drug is approved for use with a companion diagnostic, the LeukoStrat CDx FLT3 Mutation ... high-dose C consolidation (consol), and as maintenance (maint) therapy in newly diagnosed acute myeloid leukemia (AML) patients ... was found to prolong survival of FLT3-mutated AML patients when combined with conventional induction and consolidation ...
... chemotherapy - chemotherapy-induced peripheral neuropathy - chest x-ray - chiasma - child-life worker - chitin - chlorambucil ... consolidation therapy - contiguous lymphoma - continent reservoir - contingency management - continuous hyperthermic peritoneal ... high-dose chemotherapy - high-dose-rate remote brachytherapy - high-dose-rate remote radiation therapy - high-energy photon ... systemic chemotherapy - systemic disease - systemic lupus erythematosus - systemic therapy T cell - T-3 - T-cell depletion - T- ...
Consolidation treatment often entails a repetition of induction chemotherapy or the intensification chemotherapy with ... Chemotherapy, radiation therapy, targeted therapy, bone marrow transplant, supportive care[3]. Prognosis. Five-year survival ... Consolidation therapy or intensification therapy to eliminate any remaining leukemia cells. There are many different approaches ... Such combination chemotherapy usually offers the benefits of early remission and a lower risk of disease resistance. ...
Consolidation/intensification Use high doses of chemotherapy to further reduce tumor burden Typical protocols use the following ... ChemotherapyEdit. Chemotherapy is the initial treatment of choice, and most people with ALL receive a combination of ... In general, cytotoxic chemotherapy for ALL combines multiple antileukemic drugs tailored to each person. Chemotherapy for ALL ... Chemotherapy, stem cell transplantation, radiation therapy, targeted therapy[1]. Prognosis. Children: 90% five-year survival ...
Intensification chemotherapy is identical to consolidation chemotherapy but a different drug than the induction chemotherapy is ... Chemotherapy. A woman being treated with docetaxel chemotherapy for breast cancer. Cold mittens and wine coolers are placed on ... The term chemotherapy[edit]. The word chemotherapy without a modifier usually refers to cancer treatment, but its historical ... Consolidation chemotherapy is given after remission in order to prolong the overall disease-free time and improve overall ...
Induction with chemotherapy (Daunorubicin + Cytarabine), followed by consolidation chemotherapy (High dose cytarabine). Stem ... Intensive chemotherapy phase for initial 6 months and maintenance chemotherapy for 2 years. Prophylactic cranial and stem cell ... Treatment options include radiation, chemotherapy, and surgery.[58]. Stomach cancer. Treatment options include chemotherapy, ... Chemotherapy with ABVD or BEACOPP regimen and Involved field radiation therapy (IFRT).[71]. Non-Hodgkin lymphoma (NHL). Chemo- ...
... two or more cycles of a platinum-based chemotherapy were randomly assigned to receive durvalumab or a placebo as consolidation ... or metastatic urothelial carcinoma who either have disease progression during or following platinum-containing chemotherapy or ... have disease progression within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy. ...
The neutrophils, bacteria, and fluid from surrounding blood vessels fill the alveoli, resulting in the consolidation seen on ... chemotherapy treatment, or home care. HCAP is sometimes called MCAP (medical care-associated pneumonia). People may become ... Laterolateral chest radiographs can increase the diagnostic accuracy of lung consolidation and pleural effusion. A CT scan can ... Bacterial, community-acquired pneumonia classically show lung consolidation of one lung segmental lobe, which is known as lobar ...
Cases with inhomogeneous-appearing consolidation on CT have been reported, as well as aerogenous, lepidic-type spread. Some ... In numerous clinical trials conducted in NSCLC, several different platinum-based chemotherapy regimens have been shown to be ... Taxane-based (paclitaxel, docetaxel) chemotherapy was shown to induce a complete and sustained response in a liver metastasis ... or palliative chemotherapy and/or radiotherapy, depending on the disease stage and performance status of the individual patient ...
A randomized comparison of all transretinoic acid (ATRA) followed by chemotherapy and ATRA plus chemotherapy and the role of ... Core-binding factor acute myeloid leukemia: can we improve on HiDAC consolidation?. „Hematology Am Soc Hematol Educ Program". ... Intensive postremission chemotherapy in adults with acute myeloid leukemia. Cancer and Leukemia Group B. „N Engl J Med". 331 ( ... A tribute to Sidney Farber-- the father of modern chemotherapy. „Br J Haematol". 134 (1), s. 20-6, 2006. DOI: 10.1111/j.1365- ...
Common chemotherapy treatments are genotoxic. These treatments are ineffective in cancer tumor that have mutated p53 since they ... More than 500 of these CpG sites are de-methylated in neuron DNA during memory formation and memory consolidation in the ... DSBs and Memory Reconsolidation While accumulation of DSBs generally inhibits long term memory consolidation, the process of ... involved in memory consolidation. Rapid expression of egr-1, c-Fos, and Arc IEGs have been observed in response to increased ...
No signs and symptoms of lobar consolidation, meaning that the infection is restricted to small areas, rather than involving a ... Journal of Chemotherapy. 19 (Suppl 1): 17-23. PMID 18073166. [permanent dead link] Diseases Database Causes of atypical ... In addition, this form of pneumonia is atypical in presentation with only moderate amounts of sputum, no consolidation, only ... a dry irritating cough followed later by a productive cough with radiographs showing consolidation), there are in general few ...
consolidation therapy A therapy given to consolidate the gains from induction therapy. In cancer, this means chasing after any ... by drugs: pharmacotherapy, chemotherapy (also, medical therapy often means specifically pharmacotherapy). *by medical devices: ... Often multiple therapies may be tried simultaneously (combination therapy or polytherapy). Thus combination chemotherapy is ... are called neoadjuvant chemotherapy, not premedication, whereas things like anesthetics or prophylactic antibiotics before ...
The use of either radiotherapy or surgery in addition to an ALK inhibitor is known as local consolidation therapy, and as of ... It demonstrated a clear benefit against both first-line chemotherapy and first-line crizotinib. This was based on the phase 3 ... It provided good brain penetrance and a significant progression-free survival benefit against chemotherapy in the first line as ... March 4, 2017). "First-line ceritinib versus platinum-based chemotherapy in advanced ALK-rearranged non-small-cell lung cancer ...
Luke's president: Study consolidation". Cedar Rapids Gazette. Retrieved 28 June 2018. CS1 maint: discouraged parameter (link) ... Mercy also provides cardiology, dialysis and chemotherapy outreach services at rural hospitals in those seven counties. As ... 86,000-square-feet facility with 27 infusion chairs or beds for chemotherapy and 16 exam rooms. Mercy was the second hospital ...
"No more chemotherapy for Cory, says close family friend". GMA News. July 2, 2009. Retrieved July 2, 2009. Agence France Presse ... Ban paid tribute to the former president for her "exceptional courage and pivotal role in the restoration and consolidation of ... Aquino pursued chemotherapy. Following the announcement, Malacañan Palace was saddened at the disclosure, while Senators ... Her son, Benigno III, said that his mother would undergo such unspecified set of procedures before taking chemotherapy. Some ...
Treatment with chemotherapy has been used with some success, particularly using lomustine, prednisone, doxorubicin, and ... sometimes leading to lung lobe consolidation and pleural effusion.[6] Signs and symptoms include cough, loss of appetite, ...
Their active immunotherapy, BiovaxID, is a cancer vaccine whose first indication is intended to be consolidation/adjuvant ... blood following chemotherapy, and improve the duration of complete remissions by a median of 15.4 months relative to control. ... and recruiting the patient's own immune system to destroy micro-pockets of cancer cells that may remain following chemotherapy ...
Memory consolidation.[31] Signals via Gi/o inhibition of adenylyl cyclase. ... The enterochromaffin cells not only react to bad food but are also very sensitive to irradiation and cancer chemotherapy. Drugs ... They are particularly important in treating the nausea and vomiting that occur during anticancer chemotherapy using cytotoxic ... Gonzalez R, Chávez-Pascacio K, Meneses A (September 2013). "Role of 5-HT5A receptors in the consolidation of memory". ...
A systematic review from 2014 found that low doses of amphetamine also improve memory consolidation, in turn leading to ... British Journal of Pharmacology and Chemotherapy. 20: 278-284. doi:10.1111/j.1476-5381.1963.tb01467.x. PMC 1703637. PMID ... Amphetamine has been shown to improve consolidation of information (0.02 ≥ P ≤ 0.05), leading to improved recall. Devous MD, ...
... such as chemotherapy) or in acute radiation syndrome (though deuterium is not radioactive), and is due to deuterium's action in ... and third phase saw consolidation and a shift towards improvement in production and energy conservation. ... As in chemotherapy, deuterium-poisoned mammals die of a failure of bone marrow (bleeding and infection) and intestinal-barrier ...
Chemotherapy[edit]. The chemotherapy regimen depends on the tumor type.[6] Small-cell lung carcinoma (SCLC), even relatively ... consolidation (pneumonia) or pleural effusion.[7] CT imaging is typically used to provide more information about the type and ... Adjuvant chemotherapy refers to the use of chemotherapy after apparently curative surgery to improve the outcome. In NSCLC, ... Chemotherapy may be combined with palliative care in the treatment of the NSCLC. In advanced cases, appropriate chemotherapy ...
... such as chemotherapy) or in acute radiation syndrome (though deuterium is not radioactive), and is due to deuterium's action in ... and third phase saw consolidation and a shift towards improvement in production and energy conservation. ... As in chemotherapy, deuterium-poisoned mammals die of a failure of bone marrow (bleeding and infection) and intestinal-barrier ...
April 2016). "Sex-specific effects of cytotoxic chemotherapy agents cyclophosphamide and mitomycin C on gene expression, ... and it has been demonstrated that older adults experience impairments in memory consolidation as their medial prefrontal ... and the parahippoccampal cortex.These brain areas are implicated in memory retrieval and consolidation, language processing, ...
Vertes, Robert P.; Eastman, KE (2000). "The case against memory consolidation in REM sleep". Behavioral and Brain Sciences 23 ( ... "Tuberculosis chemotherapy with hydrazine derivatives of isonicotinic acid". Chest 21 (4): 385-438. doi:10.1378/chest.21.4.385 ...
Vertes, Robert P.; Eastman, KE (2000). "The case against memory consolidation in REM sleep". Behavioral and Brain Sciences. 23 ... "Tuberculosis chemotherapy with hydrazine derivatives of isonicotinic acid". Chest. 21 (4): 385-438. doi:10.1378/chest.21.4.385 ...
It is a condition where the alveoli are deflated down to little or no volume, as distinct from pulmonary consolidation, in ... If a tumor is blocking the airway, relieving the obstruction by surgery, radiation therapy, chemotherapy, or laser therapy may ...
In mice lacking SHARP1/BHLHE41 and SHARP2, IGF-2 is elevated and leads to enhanced memory consolidation.[29] ... Research is currently examining whether BHLHE40 and BHLHE41 can be used as target genes for chemotherapy.[34] ... "Enhanced memory consolidation in mice lacking the circadian modulators Sharp1 and -2 caused by elevated Igf2 signaling in the ...
consolidation chemotherapy synonyms, consolidation chemotherapy pronunciation, consolidation chemotherapy translation, English ... dictionary definition of consolidation chemotherapy. n. 1. The treatment of cancer using specific chemical agents or drugs that ... Related to consolidation chemotherapy: induction chemotherapy, salvage chemotherapy, platinum chemotherapy che·mo·ther·a·py. ( ... chemotherapy. (redirected from consolidation chemotherapy). Also found in: Thesaurus, Medical, Encyclopedia. ...
Consolidation Chemotherapies. All MeSH CategoriesAnalytical, Diagnostic and Therapeutic Techniques and Equipment Category ... Consolidation Chemotherapy. Drug treatment designed to further diminish the disease toward complete remission following ... It helps to consolidate the gains during induction chemotherapy and may be followed by MAINTENANCE CHEMOTHERAPY. ...
A 64-year-old man with acute myelogenous leukemia (FAB classification, M7) in remission received consolidation chemotherapy ... Bacillus cereus sepsis and subarachnoid hemorrhage following consolidation chemotherapy for acute myelogenous leukemia].. [ ... which developed at nadir following chemotherapy for leukemia patients. Because of the aggressive clinical course of B. cereus ... cereus sepsis would be important in the management of leukemia patients after chemotherapy. ...
Venetoclax in Combination With Intensive Induction and Consolidation Chemotherapy in Treatment Naïve AML. The safety and ... Phase 1b Study of Venetoclax in Combination With Intensive Induction and Consolidation Chemotherapy in Treatment Naïve Subjects ... of combining venetoclax with standard induction and consolidation chemotherapy for AML.. *Partial Response Rate [ Time Frame: 2 ... response rate data as to the efficacy of combining venetoclax with standard induction and consolidation chemotherapy for AML. ...
... it is not yet known whether chemotherapy and radiation therapy are more effective when given with consolidation chemotherapy in ... Trial of Postoperative Chemoradiotherapy With or Without Consolidation Chemotherapy for Cervical Cancer Patients. The safety ... The purpose of this study is to determine the efficacy and safety of consolidation chemotherapy with paclitaxel plus cisplatin ... Phase III Randomized Study of Concurrent Paclitaxel/Cisplatin Chemotherapy and Radiotherapy With or Without Consolidation ...
Consolidation chemotherapy After neoadjuvant chemoradiotherapy, patients will receive three cycles of chemotherapy. Thereafter ... Consolidation Chemotherapy for Locally Advanced Mid or Low Rectal Cancer After Neoadjuvant Concurrent Chemoradiotherapy. The ... KCSP Trial of cONsolidation Chemotherapy for Locally Advanced Mid or Low Rectal Cancer After neoadjUvant Concurrent ... Korean Society of Coloproctology (KSCP) trial of cONsolidation Chemotherapy for Locally advanced mid or low rectal cancer after ...
... standard DA consolidation treatment of acute myeloid leukemia ... of this study is to determine whether Azacitidine consolidation ... Azacitidine Compared to Conventional Chemotherapy in Consolidation of Elderly Patients (65 Years or Older) With AML in First ... Azacitidine Compared to Conventional Chemotherapy in Consolidation of Elderly Patients (65 Years or Older) With AML in First ... 1. Subjects who are not considered to be candidates to complete the consolidation. therapy due to medical or psychological ...
A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid ... A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid ... parameters of ASP2215 concomitant with induction and consolidation chemotherapy as well as evaluate the PK parameters of ... Treatment of AML in Phase 1 part is composed of 3 periods of therapy: remission induction, consolidation, and maintenance. The ...
Announces Updated Data from Phase 1 Study of Ivosidenib or Enasidenib in Combination with Standard Induction and Consolidation ... Chemotherapy in Newly Diagnosed AML Patients With an IDH Mutation ... received up to four cycles of consolidation chemotherapy while ... "These data demonstrate that combining full doses of standard induction and consolidation chemotherapy with ivosidenib or ... registration-enabling trial combining ivosidenib or enasidenib with standard induction and consolidation chemotherapy followed ...
A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid ... A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid ... A Phase 1/2 Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed ... parameters of ASP2215 concomitant with induction and consolidation chemotherapy as well as evaluate the PK parameters of ...
HEAD START 4: A Study of Different Regimens of Induction and Consolidation Chemotherapy with Stem Cell Rescue for Children ... Clinical and Molecular Risk-Tailored Intensive and Compressed Induction Chemotherapy Followed by Consolidation with ... patients will be randomly assigned to receive either one or three cycles of consolidation chemotherapy. Children with low-risk ... After the stem cells have been collected, they will be stored and then given again after the consolidation phase, to help the ...
Treatment of children with AML in first remission with either autologous bone marrow transplantation or intensive chemotherapy ... We compared autologous bone marrow transplantation with intensive consolidation chemotherapy as treatments for children with ... Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood. ... The event-free survival at three years for the nonrandomized intensive-chemotherapy group was 39 +/- 5.1 percent, and for a ...
Bone marrow transplantation versus high-dose cytarabine-based consolidation chemotherapy for acute myelogenous leukemia in ... cytarabine-based consolidation chemotherapy. Results:. After a median follow-up of 4 years, the actuarial risk of leukemic ... In this study we analyzed the results of one or more cycles of high-dose cytarabine-based consolidation chemotherapy as ... relapse was considerably lower in the transplant group than in the group treated with consolidation chemotherapy (32% +/- 26% v ...
The intensified treatment paradigm of XELOX concurrent chemoradiation followed by one cycle of consolidation chemotherapy was ... of intensified full-dose XELOX chemotherapy concomitant to radiotherapy and then resting-period consolidation chemotherapy in ... The intensified treatment paradigm of XELOX concurrent chemoradiation followed by one cycle of consolidation chemotherapy was ... More News: Adenocarcinoma , Cancer , Cancer & Oncology , Chemotherapy , Eloxatin , Intensity-Modulated Radiation Therapy , ...
Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation/ ... and in elderly patients in combination with conventional chemotherapy and as consolidation/maintenance therapy in young and ... Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation/ ... "Multiple Myeloma Treated With Thalidomide Before Autotransplant or With Conventional Chemotherapy and as Consolidation/ ...
Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute ... Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute ... Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute ... LR-ALL patients were randomized to receive or not early consolidation chemotherapy (C-1). After receiving C-1, IR patients were ...
A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With ... A Pilot Trial of Sequential Chemotherapy With Antimetabolite Induction, High-Dose Alkylating Agent Consolidation With ... as a chemotherapy backbone onto which a companion immunotherapy protocol will be offered.. An identical chemotherapy regimen ... Patients will then receive consolidation therapy with. three cycles of high-dose alkylating agents. First, patients will ...
Syed A. Abutalib, MD, and Nelli Bejanyan, MD, on Adult ALL and Consolidation Chemotherapy: Results From a CIBMTR Study 2016 ASH ...
... consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 ... designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, ... Study of Crenolanib vs Midostaurin Following Induction Chemotherapy and Consolidation Therapy in Newly Diagnosed FLT3 Mutated ... consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. About 510 ...
For AML patients undergoing outpatient-based intensive consolidation chemotherapy with antibiotic prophylaxis, the second cycle ... of consolidation on an ambulatory basis. Antimicrobial prophylaxis consisted of ciprofloxacin, amoxicillin and fluconazole. ... Ambulatory consolidation chemotherapy for acute myeloid leukemia (AML) is frequently associated with bloodstream infections but ... of bacteremias and their respective antibiotic susceptibility patterns in AML patients receiving ambulatory-based consolidation ...
Consolidation treatment for AML is given soon after induction treatment to keep leukemia cells from coming back. Learn about ... Chemotherapy. Chemotherapy is the main consolidation treatment for AML. Chemotherapy is given soon after remission has been ... A targeted therapy drug called a tyrosine kinase inhibitor may be added to the consolidation chemotherapy regimen for people ... Consolidation treatments for acute myelogenous leukemia. Consolidation treatment is also called post-remission therapy. The ...
... and intensive consolidation chemotherapy (CCT). Assessment was made by patient questionnaire via the treating centers for ... compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. ... and intensive consolidation chemotherapy (CCT). Assessment was made by patient questionnaire via the treating centers for ... compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. ...
Chemotherapy safety. *Learn how to keep you and your family safe while you are having anticancer drugs. ... Consolidation 5-2 ida (cytarabine, idarubicin). This treatment may be given for up to two cycles. Your doctor will advise you ... This treatment involves having chemotherapy through a central venous access device (CVAD). Your doctor or nurse will explain ... Ask your doctor or nurse for eviQ patient information - Memory changes and chemotherapy (chemo brain). ...
Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy in patients ... N2 - Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy in ... AB - Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy in ... abstract = "Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy ...
Latest: FDA Approves Adcetris (brentuximab vedotin) in Combination with Chemotherapy for Adults with Previously Untreated ... Classical Hodgkin Lymphoma Consolidation. 1.8 mg/kg up to a maximum of 180 mg. Intravenous infusion over 30 minutes. Initiate ... cHL consolidation. Adcetris is indicated for the treatment of adult patients with cHL at high risk of relapse or progression as ... Table 10: Efficacy Results in Patients with Classical Hodgkin Lymphoma Post-auto-HSCT Consolidation (Study 3: AETHERA). * Not ...
Table 10: Efficacy Results in Patients with Classical Hodgkin Lymphoma Post-auto-HSCT Consolidation (Study 3: AETHERA). ... 1.2 mg/kg up to a maximum of 120 mg in combination with chemotherapy. Intravenous infusion over 30 minutes. Administer every 2 ... Classical Hodgkin Lymphoma Consolidation. 1.8 mg/kg up to a maximum of 180 mg. Intravenous infusion over 30 minutes. Initiate ... cHL consolidation. ADCETRIS is indicated for the treatment of adult patients with cHL at high risk of relapse or progression as ...
A randomized comparison of ATRA followed by chemotherapy and ATRA plus chemotherapy, and the role of maintenance therapy in ... we decided to omit cytarabine and etoposide from consolidation therapy and used an anthracycline-based consolidation with the ... Consolidation Therapy. Molecular response.. Of the 109 patients who achieved HCR, 92 have at present completed the 3 ... Consolidation treatment was associated with very low toxicity and no deaths in remission were recorded. Molecular assessment of ...
... treatment for ALL typically consists of two phases of induction and consolidation. Chemotherapy and adequate supportive care ... Chemotherapy during this phase is given intravenously or orally in combination. Some chemotherapy medication may also be ... Chemotherapy is advised in those with active, symptomatic disease.. Chemotherapy agents include alkylating agents (chlorambucil ... Consolidation stage for AML. The aim of this phase is to kill the remaining leukemia cells in the body. Treatment involves ...
Acute myeloid leukemia consolidation therapy involves multiple courses of chemotherapy or high-dose chemotherapy with stem cell ... Consolidation Chemotherapy. Consolidation chemotherapy typically consists of 3 to 4 cycles of cytarabine given in high doses ... Consolidation therapy can be accomplished with multiple courses of chemotherapy or high-dose chemotherapy with autologous or ... New Consolidation Chemotherapy Regimens: Development of new multi-drug chemotherapy treatment regimens that incorporate new or ...
... with chemotherapy may be classified into two phases: induction of remission and post-remission therapy. ... In terms of drugs, the key difference between consolidation chemotherapy and induction chemotherapy is that in induction ... Consolidation therapy involves intensive chemotherapy given right after recovery from induction. It is administered as quickly ... In case of younger patients, key options for consolidation therapy are (a) multiple cycles of high-intensity chemotherapy using ...
  • Drug treatment designed to further diminish the disease toward complete remission following INDUCTION CHEMOTHERAPY. (nih.gov)
  • A 64-year-old man with acute myelogenous leukemia (FAB classification, M7) in remission received consolidation chemotherapy with mitoxantrone/cytosine arabinoside. (nih.gov)
  • 1. To obtain preliminary data as to the efficacy (Complete Remission (CR), Complete remission with incomplete platelet recovery (CRp), Complete remission with incomplete hematologic recovery (CRi), and minimal residual disease (MRD) negative CR) of combining venetoclax with standard induction and consolidation chemotherapy for AML. (clinicaltrials.gov)
  • Treatment of AML in Phase 1 part is composed of 3 periods of therapy: remission induction, consolidation, and maintenance. (centerwatch.com)
  • We compared autologous bone marrow transplantation with intensive consolidation chemotherapy as treatments for children with AML in first remission. (nih.gov)
  • Treatment of children with AML in first remission with either autologous bone marrow transplantation or intensive chemotherapy prolongs event-free survival equally. (nih.gov)
  • In this study we analyzed the results of one or more cycles of high-dose cytarabine-based consolidation chemotherapy as compared with allogeneic BMT in first remission. (uni-bonn.de)
  • The results in 28 adult patients, aged 16 to 45 years, who underwent a closely HLA-matched BMT for AML in first remission were compared with those in 54 consecutive, age-matched, adult patients treated with one or more cycles of high-dose, cytarabine-based consolidation chemotherapy. (uni-bonn.de)
  • Our results show that BMT in first remission AML did not offer a disease-free survival advantage over intensive postremission consolidation chemotherapy. (uni-bonn.de)
  • Consolidation treatment is also called post-remission therapy. (cancer.ca)
  • Chemotherapy is given soon after remission has been reached (2-3 weeks after blood cell counts return to normal). (cancer.ca)
  • METHODS: A cross-sectional study of sexual health and infertility was conducted in 479 patients with acute myeloid leukemia (AML) in first complete remission (CR) who were entered into the UK MRC AML 10 trial comparing allogeneic BMT (Allo-BMT), autologous BMT (A-BMT), and intensive consolidation chemotherapy (CCT). (ox.ac.uk)
  • Consolidation treatment was associated with very low toxicity and no deaths in remission were recorded. (bloodjournal.org)
  • 2 (2) The best therapy results, in terms of complete remission (CR) and disease-free survival (DFS), have been obtained using ATRA and chemotherapy for remission induction. (bloodjournal.org)
  • Chemotherapy and adequate supportive care results in complete remission rates of about 98% for children and 85% for adults. (news-medical.net)
  • Common regimens for consolidation in childhood ALL include high dose methotrexate with mercaptopurine, high dose asparaginase over an extended period and a repetition of the initial induction therapy in the first few months of remission. (news-medical.net)
  • The treatment of acute myeloid leukemia (AML) is divided into two phases: remission induction and consolidation/maintenance. (texasoncology.com)
  • Remission induction chemotherapy is administered to produce a complete remission in the bone marrow. (texasoncology.com)
  • To prevent recurrence of leukemia, intensive therapy, called consolidation, is given immediately after recovery from remission induction therapy. (texasoncology.com)
  • Patients with newly diagnosed AML who achieve a complete remission following remission induction therapy have historically been advised to receive consolidation treatment with either high-dose chemotherapy supported by an allogeneic HLA-matched sibling stem cell transplant, high-dose chemotherapy and autologous stem cell transplant, or conventional-dose chemotherapy delivered without stem cell support. (texasoncology.com)
  • Treatment of acute myeloid leukemia (AML) with chemotherapy may be classified into two phases: induction of remission and post-remission therapy. (news-medical.net)
  • Once complete remission is achieved, post remission therapy is started and it involves consolidation therapy and maintenance. (news-medical.net)
  • While induction chemotherapy aims to lower the number of AML cells, the main aim of post remission therapy is to prevent disease recurrence. (news-medical.net)
  • Post-remission therapy of adult acute myeloid leukemia: high dose cytosine-arabinoside versus other consolidation regimens/Konsolidaciona terapija akutne mijeloidne leukemije: visoke doze citozinarabinozida naspram drugih konsolidacionih rezima sa citozin-arabinozidom. (thefreelibrary.com)
  • Once your leukemia is in remission, the next phase of treatment is consolidation. (ahealthyme.com)
  • ATRA alone can often put APL into remission, but combining it with chemotherapy (usually daunorubicin and cytarabine) gives better long-term results. (cancer.org)
  • The aim of this study was to evaluate the role of consolidation radiotherapy (RT) in advanced-stage Hodgkin's disease (HD) with initial bulky sites after radiological complete remission (CR) or partial response (PR) with positron emission tomography-negative (metabolic CR) following standard chemotherapy (ABVD [Adriamycin, bleomycin, vinblastine, and dacarbazine]) six to eight cycles. (dovepress.com)
  • OBJECTIVES: - Determine, preliminarily, the safety of incorporating arsenic trioxide (ATO) into cytarabine and daunorubicin hydrochloride-based consolidation therapy followed by tretinoin maintenance therapy in patients receiving induction tretinoin and daunorubicin hydrochloride with acute promyelocytic leukemia (APL) induced into remission with tretinoin and daunorubicin hydrochloride. (ichgcp.net)
  • The goal of chemotherapy is to damage or kill cancer cells so there's either no sign of illness (remission) or the disease's progress is slowed. (lls.org)
  • Chemotherapy can produce long-term remission or outright cure for many persons, depending on the cancer type and its extent. (lls.org)
  • If APL returns, most children can be put into a second remission using arsenic trioxide, alone or combined with chemotherapy and stem cell transplantation. (stjude.org)
  • Remission induction therapy uses chemotherapy to kill the existing leukemia cells in your body. (healthline.com)
  • Consolidation therapy, which is also known as post-remission therapy, is crucial for keeping AML in remission and preventing a relapse. (healthline.com)
  • Or it can be used for leukemia that doesn't go into remission by the end of consolidation. (ahealthyme.com)
  • The customary treatment for AML involves an initial "induction" phase that uses a combination of chemotherapy agents to put the disease into a first remission. (bio-medicine.org)
  • When should patients receive consolidation chemotherapy before allogeneic hematopoietic cell transplantation for acute myeloid leukemia in first complete remission? (lww.com)
  • ALL is typically treated initially with chemotherapy aimed at bringing about remission . (wikipedia.org)
  • After the disease is in remission, they are then given consolidation therapy. (mskcc.org)
  • More than 3 decades ago, the first trials of autologous hematopoietic cell transplantation as consolidation therapy for acute myeloid leukemia (AML) in first remission were conducted. (ascopost.com)
  • Concurrent radiotherapy with cisplatin-based chemotherapy has become the standard treatment for patients with cervical cancer. (clinicaltrials.gov)
  • Therefore, the investigators are going to perform the efficacy and safety study of postoperative concurrent paclitaxel/cisplatin chemotherapy and radiotherapy with consolidation chemotherapy in high-risk patients with early-stage cervical cancer following radical hysterectomy. (clinicaltrials.gov)
  • Purpose: The optimal combination of chemotherapy and radiotherapy (RT) and the role of consolidation chemotherapy in patients with locally advanced non-small-cell lung cancer (NSCLC) are unknown. (elsevier.com)
  • Seung, SK & Ross, HJ 2009, ' Phase II Trial of Combined Modality Therapy With Concurrent Topotecan Plus Radiotherapy Followed by Consolidation Chemotherapy for Unresectable Stage III and Selected Stage IV Non-Small-Lung Cancer ', International Journal of Radiation Oncology Biology Physics , vol. 73, no. 3, pp. 802-809. (elsevier.com)
  • Before transplantation can take place, the person receiving the transplant will be given aggressive high-dose chemotherapy and radiotherapy to destroy any cancerous cells in their body. (news-medical.net)
  • Standard treatments involve chemotherapy and radiotherapy. (wikipedia.org)
  • One hundred and thirteen patients who received radiotherapy (RT) as consolidation postchemotherapy (RT group) were compared to 79 patients who did not receive RT (non-RT group). (dovepress.com)
  • Additionally, chemotherapy and/or radiotherapy have shown the roles to improve oncologic outcomes by controlling local recurrence. (beds.ac.uk)
  • So far, no reliable molecular or pathologic biomarkers to foster pathologic complete response (pCR), which means complete regression of the tumor after radiotherapy and/or chemotherapy, was identified. (beds.ac.uk)
  • We suggest that high-dose MVP chemotherapy followed by an early response-adapted intensification strategy may be effective and minimize the number of patients who receive radiotherapy or ASCT in the early course of treatment. (yonsei.ac.kr)
  • Treatments for acute lymphoblastic leukaemia usually involve a combination of chemotherapy and radiotherapy. (nhsinform.scot)
  • PMID 6406037 , 1983 (1974-78) - "A randomized study of radiotherapy versus radiotherapy plus chemotherapy in stage I-II non-Hodgkin's lymphomas. (wikibooks.org)
  • If the leukemia has spread to the CNS, treatment may include chemotherapy given directly into the spinal fluid (called intrathecal chemotherapy). (cancer.ca)
  • The drug used in intrathecal chemotherapy is methotrexate or cytarabine. (cancer.ca)
  • Radiation therapy is sometimes given to the brain and spinal cord along with intrathecal chemotherapy. (cancer.ca)
  • They need CNS prophylaxis in the form of cranial irradiation (less commonly used now), intrathecal (methotrexate, cytarabine, steroids) and high-dose systemic chemotherapy (methotrexate, cytarabine, L-asparaginase). (news-medical.net)
  • APL rarely spreads to the brain or spinal cord, so intrathecal chemotherapy is usually not needed. (cancer.org)
  • The same needle can be used to insert medicines to prevent or treat leukemia in the brain or spinal cord (intrathecal chemotherapy). (chop.edu)
  • This is called intrathecal chemotherapy. (ucsfhealth.org)
  • Patients are routinely given six or more injections of intrathecal chemotherapy to prevent recurrence of ALL. (ucsfhealth.org)
  • CNS therapy is given as intrathecal chemotherapy, where drugs are given directly into the cerebrospinal fluid (CSF) around the spinal cord. (cancer.ca)
  • [2] Additional treatments may include intrathecal chemotherapy or radiation therapy if spread to the brain has occurred. (wikipedia.org)
  • This process is called intrathecal chemotherapy. (mskcc.org)
  • If the patient has not had cranial irradiation, intrathecal chemotherapy for CNS prophylaxis is continued in the maintenance phase. (pediatriconcall.com)
  • Chemotherapy, usually with methotrexate, is also given into the spinal fluid (known as intrathecal chemo) for at least 4 doses, each separated by a week. (cancer.org)
  • In this research study, the investigators are combining the use of venetoclax (the investigational drug being studied) with chemotherapy drugs daunorubicin and cytarabine. (clinicaltrials.gov)
  • The purpose of phase 1 part in this study is to determine the maximum tolerated dose (MTD) and/or recommended expansion dose (RED) of ASP2215 concomitant with cytarabine/idarubicin as induction chemotherapy based on the status of the onset of dose-limiting toxicity (DLT) in newly diagnosed Acute Myeloid Leukemia (AML) subjects. (centerwatch.com)
  • Phase 1 part will also evaluate safety and tolerability and characterize the pharmacokinetic (PK) parameters of ASP2215 concomitant with induction and consolidation chemotherapy as well as evaluate the PK parameters of cytarabine concomitant with ASP2215. (centerwatch.com)
  • As of the August 1, 2018 data cut-off, 60 newly diagnosed AML patients with mIDH1 received 500 mg of ivosidenib and standard induction chemotherapy (daunorubicin 60 mg/m2/day or idarubicin 12 mg/m2/day x 3 days with cytarabine 200 mg/m2/day x 7 days) and 93 newly diagnosed AML patients with mIDH2 received 100 mg of enasidenib and standard induction chemotherapy. (tmcnet.com)
  • The Spanish PETHEMA group designed a protocol for newly diagnosed PML/RAR-positive acute promyelocytic leukemia (APL) in which induction and consolidation followed the original AIDA regimen, except for the omission of cytarabine and etoposide from consolidation. (bloodjournal.org)
  • 3) The additional benefit, if any, provided by cytarabine administered in induction and/or in consolidation remains unclear. (bloodjournal.org)
  • In fact, although randomized trials comparing different chemotherapy induction regimens in APL have not been performed, the inclusion of cytarabine in addition to daunorubicin, with or without other chemotherapy agents (eg, thioguanine, etoposide), does not appear to significantly affect disease outcome, 10 nor does it seem to provide better results than those obtained with high-dose daunorubicin 11-14 or idarubicin alone. (bloodjournal.org)
  • In case of younger patients, key options for consolidation therapy are (a) multiple cycles of high-intensity chemotherapy using cytarabine and (b) allogeneic or autologous stem cell transplant. (news-medical.net)
  • In terms of drugs, the key difference between consolidation chemotherapy and induction chemotherapy is that in induction therapy cytarabine and anthracycline are used, while in consolidation only cytarabine is used. (news-medical.net)
  • They may be treated with low intensity chemotherapy usually involving 1 to 2 cycles of cytarabine or 1 to 2 cycles of standard dose cytarabine usually along with daunorubicin or idarubicin. (news-medical.net)
  • This is usually similar to induction, using both ATRA and chemotherapy (daunorubicin, sometimes along with cytarabine). (cancer.org)
  • This trial is looking at using liposomal daunorubicin, mitoxantrone, fludarabine and cytarabine to improve chemotherapy for acute myeloid leukaemia. (cancerresearchuk.org)
  • High dose cytarabine (HD Ara-C) is one of the standard treatments that doctors use for consolidation chemotherapy. (cancerresearchuk.org)
  • They think that the combination of fludarabine and cytarabine might work better as consolidation chemotherapy than HD Ara-C for people who have standard risk of their leukaemia coming back. (cancerresearchuk.org)
  • Consolidation therapy: Patients receive cytarabine IV continuously on days 1-3, daunorubicin hydrochloride IV on days 1-3, and arsenic trioxide IV over 1-2 hours once daily, 5 days a week, beginning on day 8 and continuing for 6 weeks. (ichgcp.net)
  • This phase II trial compares three chemotherapy regimens consisting of bendamustine, rituximab, high dose cytarabine, and acalabrutinib and studies how well they work in treating patients with newly diagnosed mantle cell lymphoma. (rochester.edu)
  • The injection is a form of chemotherapy called ARAC (Cytarabine). (caringbridge.org)
  • In addition, it is not yet known whether chemotherapy and radiation therapy are more effective when given with consolidation chemotherapy in treating cervical cancer. (clinicaltrials.gov)
  • Patients may not have previously received chemotherapy or radiation therapy. (mskcc.org)
  • Treatment may involve some combination of chemotherapy, radiation therapy, targeted therapy, and bone marrow transplant, in addition to supportive care and palliative care as needed. (wikipedia.org)
  • The phase III PROCLAIM study evaluated overall survival (OS) of concurrent pemetrexed-cisplatin and thoracic radiation therapy (TRT) followed by consolidation pemetrexed, versus etoposide-cisplatin and TRT followed by nonpemetrexed doublet consolidation therapy. (elsevier.com)
  • Today's treatments for leukemia, lymphoma and myeloma sometimes combine chemotherapy with radiation therapy. (lls.org)
  • A procedure in which bone marrow or peripheral blood stem cells from a donor (usually related) are collected, stored, and infused into a patient (recipient) following high-dose chemotherapy and/or radiation therapy. (themmrf.org)
  • Giving alisertib alone or with chemotherapy and radiation therapy may be effective in treating patients with rhabdoid tumors. (cancer.gov)
  • All participants on this study will have surgery to remove as much of the primary tumor as safely possible, radiation therapy, and chemotherapy. (stanford.edu)
  • The amount of radiation therapy and type of chemotherapy received will be determined by the participant's treatment stratum. (stanford.edu)
  • For high-risk stage II and III patients, this chemotherapy regimen (without genetic manipulation of PBPCs) will serve as a chemotherapy backbone onto which a companion immunotherapy protocol will be offered. (knowcancer.com)
  • An identical chemotherapy regimen will be offered to stage four patients as a backbone for a trial of retroviral transduction of the MDR1 and NeoR genes into harvested PBPCs. (knowcancer.com)
  • A targeted therapy drug called a tyrosine kinase inhibitor may be added to the consolidation chemotherapy regimen for people with leukemia cells that have a certain genetic mutation called FLT3. (cancer.ca)
  • The duration of ZARXIO therapy needed to attenuate chemotherapy-induced neutropenia may be dependent on the myelosuppressive potential of the chemotherapy regimen employed. (rxlist.com)
  • Any change in a chemotherapy protocol (delaying courses, dose reduction, or changing the drugs) may impact on the prognosis of acute leukemia patients.13,14 Despite many data on the mortality rates of invasive fungal diseases in hematology patients, there has been no study which looks at their impact in survivors of the event on the application of the acute leukemia chemotherapy regimen which had been initially planned. (haematologica.org)
  • Adcetris is indicated for the treatment of adult patients with cHL at high risk of relapse or progression as post-autologous hematopoietic stem cell transplantation (auto-HSCT) consolidation. (drugs.com)
  • Studies have shown that stem cell transplants are more effective than chemotherapy in reducing the risk of disease relapse. (news-medical.net)
  • The objective of this study was to compare the survival rate and the relapse rate among the patients who received HDAC during consolidation therapy and among the patients who did not receive HDAC during consolidation therapy. (thefreelibrary.com)
  • Several reports have suggested inferior survival in patients with DLBCL who have residual PET scan positivity at the end of chemotherapy and other studies have shown that patients who have a positive interim PET scan (after 2-4 cycles of therapy) predict higher risk of subsequent relapse. (medscape.com)
  • To prevent relapse at this location, chemotherapy must be injected directly into the fluid that bathes the spinal column. (ucsfhealth.org)
  • Treatment designed to help prevent a relapse of a disease following the successful primary treatments (INDUCTION CHEMOTHERAPY and CONSOLIDATION CHEMOTHERAPY) with a long-term low-dose drug therapy. (bioportfolio.com)
  • ATRA and chemotherapy are given for about a year to avoid a relapse of APL. (stjude.org)
  • Among 116 eligible patients, MRD status after the second consolidation rather than induction or first consolidation could discriminate high-risk relapse patients ( P = .001). (bloodjournal.org)
  • disease-free survival [DFS]: 61.7% vs 19.6%, P = .001), whereas chemotherapy/auto-HSCT achieved a low relapse rate (5.3%) and high DFS (94.7%) for low-risk patients. (bloodjournal.org)
  • Even though most of the cancer was killed in the Induction phase, without further chemotherapy Josh would quickly relapse. (caringbridge.org)
  • A bone marrow transplant, also known as a stem cell transplant, may be used as consolidation therapy in people at high risk of relapse or for treating relapse when it occurs. (mayoclinic.org)
  • 1. Subjects who are not considered to be candidates to complete the consolidation therapy due to medical or psychological reasons. (knowcancer.com)
  • Phase 2 cohort will also evaluate safety and characterize the PK parameters of ASP2215 in combination with induction and consolidation therapy followed by maintenance therapy in newly diagnosed FLT3-mutated AML subjects. (centerwatch.com)
  • The addition of an IDH inhibitor to induction and consolidation followed administration as single-agent maintenance therapy for patients with newly diagnosed AML will be evaluated further in a Phase 3 randomized study. (tmcnet.com)
  • HOVON 150 AML/AMLSG 29-18 is an intergroup sponsored, global, registration-enabling trial combining ivosidenib or enasidenib with standard induction and consolidation chemotherapy followed by a maintenance therapy period in frontline AML patients with an IDH1 or IDH2 mutation, respectively. (tmcnet.com)
  • The DLT assessment period for making a decision of whether or not to proceed to the next dose is defined as the shorter of the following 2 periods: 39 days from the start of the treatment with ASP2215 in the induction period or days between the start of induction therapy and the start of the first consolidation therapy. (clinicaltrials.gov)
  • For safety assessment during the expansion part, the DLT assessment period includes Cycle 1 of consolidation therapy in addition to the period defined above. (clinicaltrials.gov)
  • Children with low-risk medulloblastoma will all receive a single cycle of consolidation therapy. (mskcc.org)
  • multiple myeloma as induction treatment in young patients, with Dexamethasone before autotransplant, and in elderly patients in combination with conventional chemotherapy and as consolidation/maintenance therapy in young and elderly patients at plateau-phase. (bioportfolio.com)
  • Patients will then receive consolidation therapy with three cycles of high-dose alkylating agents. (knowcancer.com)
  • You may be offered a stem cell transplant for consolidation therapy for AML. (cancer.ca)
  • In consolidation phase Imatinib (a tyrosine kinase inhibitor) has also been used as a single agent or part of combination therapy. (news-medical.net)
  • The more intensive the chemotherapy and the closer together the courses of therapy are given, the less chance the leukemia has of returning. (texasoncology.com)
  • Consolidation therapy can be accomplished with multiple courses of chemotherapy or high-dose chemotherapy with autologous or allogeneic stem cell transplantation. (texasoncology.com)
  • Despite the initial choice of consolidation therapy, it is important to determine the availability of a marrow or stem cell donor as soon as possible following the initial diagnosis of AML. (texasoncology.com)
  • Consolidation therapy involves intensive chemotherapy given right after recovery from induction. (news-medical.net)
  • The efficacy and safety of lenalidomide (LEN) consolidation therapy and subsequent LEN maintenance therapy after high-dose therapy with autologous peripheral blood stem cell transplantation (auto-PBSCT) were evaluated in patients with newly diagnosed symptomatic multiple myeloma (MM). Forty-one patients were enrolled and received high-dose dexamethasone (DEX) therapy as an initial induction. (springer.com)
  • One hundred days after auto-PBSCT, patients received consolidation therapy consisting two cycles of LEN plus low-dose DEX (Ld) and LEN maintenance therapy. (springer.com)
  • These observations suggest that LEN consolidation and maintenance therapy are effective and safe, and provide favorable response rates in patients with MM. (springer.com)
  • High-dose therapy with single autologous transplantation versus chemotherapy for newly diagnosed multiple myeloma: a systematic review and meta-analysis of randomized controlled trials. (springer.com)
  • Consolidation (intensification) therapy. (ahealthyme.com)
  • ATRA plus ATO is also being studied as an option for consolidation therapy. (cancer.org)
  • What is the role of consolidation therapy in the treatment of primary mediastinal B-cell lymphoma (PMBCL)? (medscape.com)
  • Prior to the wide use and adaptability to PET scans, most patients underwent consolidative RT or high-dose chemotherapy and autologous hematopoietic stem cell transplantation (auto-HSCT) after completion of systemic therapy. (medscape.com)
  • Further, when PET-positive patients received RT consolidation, no significant difference in outcome was observed between PET-positive and PET-negative patients, suggesting that some patients can avoid undergoing RT when PET is used to guide therapy. (medscape.com)
  • Prolongation of progression-free survival and overall survival have been reported with consolidation therapy after first-line chemotherapy in non-small cell lung cancer, but only a few pharmacoeconomic analyses have been performed. (naver.com)
  • We performed a pharmacoeconomic analysis to assess the cost-effectiveness of consolidation therapy with pemetrexed compared with non-consolidation therapy. (naver.com)
  • We developed a Markov model to evaluate the incremental cost-effectiveness ratio (ICER) of consolidation therapy with pemetrexed compared with non-consolidation therapy based on previous reports. (naver.com)
  • The ICER for consolidation therapy with pemetrexed was about US$ 109,024/life years gained (LYG) (JPY 12.5 million/LYG) and US$ 203,022/quality-adjusted life years (QALY) (JPY 23.3 million/QALY) for all histology. (naver.com)
  • This result indicates that it is difficult to use consolidation therapy as the standard of care in Japan while being covered by general medical insurance. (naver.com)
  • YUHSpace: Early response to high-dose methotrexate, vincristine, and procarbazine chemotherapy-adapted strategy for primary CNS lymphoma: no consolidation therapy for patients achieving early complete response. (yonsei.ac.kr)
  • Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised phase 3 study. (qxmd.com)
  • Patients are evaluated between days 60-67 and proceed to consolidation therapy. (ichgcp.net)
  • The introduction of all- trans retinoic acid (ATRA) therapy resulted in terminal differentiation of APL cells and a 90-95% CR rate in patients ( 1 , 4 ), and subsequent combination of ATRA with chemotherapy raised the 5-year disease-free survival (DFS) rate up to 74% ( 5 ). (pnas.org)
  • In a previous study with a median follow-up of 18 months, we randomized patients to receive either ATRA or ATO singly, or ATRA/ATO-based regimens incorporating chemotherapy treatment as a frontline therapy for new APL cases. (pnas.org)
  • 1999 ), maintenance therapy, and consolidation chemotherapy (Rossi et al. (springer.com)
  • However, a phase II trial of sorafenib in conjunction with chemotherapy as maintenance therapy in extensive-stage small-cell lung cancer showed that combination therapy has significant toxicity at current dose levels and is associated with disappointing efficacy data (Sharma et al. (springer.com)
  • The goal of consolidation therapy is to destroy any remaining leukemia cells. (healthline.com)
  • Treatment for recurrent childhood ALL usually includes giving induction chemotherapy again (called reinduction therapy). (cancer.ca)
  • It is followed by consolidation and maintenance therapy. (cancer.ca)
  • These are induction therapy, consolidation therapy and symptom control. (macmillan.org.uk)
  • Induction therapy includes chemotherapy, targeted therapies and steroids. (macmillan.org.uk)
  • Consolidation therapy is high-dose treatment and a stem cell transplant. (macmillan.org.uk)
  • Data from a clinical trial in patients with acute lymphoblastic leukemia (ALL) supports the use of teniposide as consolidation therapy in adults with ALL, in combination with other chemotherapy agents [Linker 1991] . (drugs.com)
  • Others may need chemotherapy as part of their consolidation therapy. (mskcc.org)
  • After consolidation therapy, people with high-risk disease may stay on maintenance therapy for a few years to keep the cancer from coming back. (mskcc.org)
  • This therapy is given intermittently and combines ATRA and low-dose chemotherapy. (mskcc.org)
  • Patients with invasive fungal disease, even though they initially survive, undergo significant changes to their chemotherapy therapy. (haematologica.org)
  • Risk-directed therapy included recommending allogeneic hematopoietic stem cell transplantation (allo-HSCT) for high-risk patients and chemotherapy/autologous-HSCT (auto-HSCT) for low-risk patients. (bloodjournal.org)
  • Chemotherapy, which uses drugs to kill cancer cells, is typically used as an induction therapy for children and adults with acute lymphocytic leukemia. (mayoclinic.org)
  • Targeted therapy may be used during or after chemotherapy. (mayoclinic.org)
  • Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood. (nih.gov)
  • of the remaining 343 patients, 232 were randomly assigned to receive six courses of intensive chemotherapy (117 patients) or autologous transplantation (115 patients). (nih.gov)
  • 0.001) but a higher rate of treatment-related mortality (15 percent vs. 2.7 percent, P = 0.005) in the group treated with autologous transplantation than in the intensive-chemotherapy group. (nih.gov)
  • A phase III randomized multi-center study designed to compare the efficacy of crenolanib with that of midostaurin when administered following induction chemotherapy, consolidation chemotherapy and bone marrow transplantation in newly diagnosed AML subjects with FLT3 mutation. (roswellpark.org)
  • About 510 subjects will be randomized in a 1:1 ratio to receive either crenolanib in addition to standard first line treatment of AML (chemotherapy and if eligible, transplantation) (arm A) or midostaurin and standard treatment (arm B). Potentially eligible subjects will be registered and tested for the presence of FLT3 mutation. (roswellpark.org)
  • Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. (ox.ac.uk)
  • Stem cell transplantation is used to intensify the chemotherapies and radiotherapies as it replaces destroyed stem cells. (news-medical.net)
  • Patients under age 60 without an allogeneic donor were treated with either autologous stem cell transplantation, or non-stem cell supported conventional-dose chemotherapy consolidation. (texasoncology.com)
  • The patients treated with allogeneic or autologous stem cell transplantation were more likely to be cured of their disease than the patients receiving conventional-dose consolidation chemotherapy. (texasoncology.com)
  • Evaluation at 4 years from initial treatment revealed that patients treated with allogeneic stem cell transplantation had a 55% chance of being alive without evidence of disease recurrence and patients treated with autologous stem cell transplantation had a 48% chance of being alive without evidence of disease recurrence, compared to only 30% for patients treated with conventional-dose consolidation chemotherapy. (texasoncology.com)
  • It can be risky due to the high intensity chemotherapy or radiation given prior to stem cell transplantation. (news-medical.net)
  • A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma: intergroupe francais du myeloma. (springer.com)
  • Phase I/II study of tandem high-dose chemotherapy with autologous peripheral blood stem cell transplantation for advanced multiple myeloma. (springer.com)
  • ZARXIO is indicated to reduce the duration of neutropenia and neutropenia-related clinical sequelae ‚ e.g.‚ febrile neutropenia, in patients with nonmyeloid malignancies undergoing myeloablative chemotherapy followed by bone marrow transplantation [see Clinical Studies ]. (rxlist.com)
  • Very high dose chemotherapy followed by stem cell transplantation can also be used. (lls.org)
  • Attempts have been made to improve prognosis of DH-DLBCL patients with intensified chemotherapy schemes like DA-EPOCH-R, standard treatment of Burkitt lymphoma with high dose multi-agent chemotherapy (R-CODOX-M/R-IVAC) and autologous stem cell transplantation. (centerwatch.com)
  • All patients had a probable or proven invasive fungal disease, were treated within or according to a given protocol of chemotherapy, survived at least four weeks after the invasive fungal disease diagnosis, and were not transplanted, either because they had no indication of hematopoietic cell transplantation (HCT) or they had no donor. (haematologica.org)
  • In the study, adult patients under 60 years of age with newly-diagnosed FLT3-mutated acute myeloid leukemia (AML) who received the investigational compound PKC412 (midostaurin) plus standard induction and consolidation chemotherapy experienced a 23% improvement in overall survival (OS) (hazard ratio HR = 0. (thefreedictionary.com)
  • Bacillus cereus sepsis and subarachnoid hemorrhage following consolidation chemotherapy for acute myelogenous leukemia]. (nih.gov)
  • Fatal subarachnoid hemorrhage has been reported to be associated with B. cereus sepsis, which developed at nadir following chemotherapy for leukemia patients. (nih.gov)
  • Because of the aggressive clinical course of B. cereus sepsis, including the risk for subarachnoid hemorrhage, early treatment with effective antibiotics for B. cereus sepsis would be important in the management of leukemia patients after chemotherapy. (nih.gov)
  • This research study is studying the combination of venetoclax and chemotherapy as a possible treatment for acute myelogenous leukemia (AML). (clinicaltrials.gov)
  • A Study of ASP2215 in Combination With Induction and Consolidation Chemotherapy in Patients With Newly Diagnosed Acute Myeloid Leukemia. (centerwatch.com)
  • SAN DIEGO, Dec. 03, 2018 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (NASDAQ:AGIO), a leader in the field of cellular metabolism to treat cancer and rare genetic diseases, today presented data from a Phase 1 study evaluating ivosidenib or enasidenib in combination with standard induction and consolidation chemotherapy in patients with newly diagnosed acute myeloid leukemia (AML) and an isocitrate dehydrogenase (IDH)1 or IDH2 mutation. (tmcnet.com)
  • These data demonstrate that combining full doses of standard induction and consolidation chemotherapy with ivosidenib or enasidenib is well tolerated and has the potential to provide benefit for AML patients in the frontline setting," said Eytan Stein, M.D., study investigator and attending physician in the leukemia service at Memorial Sloan Kettering Cancer Center. (tmcnet.com)
  • Early and delayed consolidation chemotherapy significantly improves the outcome of children with intermediate risk acute lymphoblastic leukemia. (haematologica.org)
  • BACKGROUND AND OBJECTIVES: To evaluate the impact of early and delayed consolidation chemotherapy on the outcome of children with acute lymphoblastic leukemia (ALL) stratified according to risk groups. (haematologica.org)
  • The goal of consolidation treatment for acute myelogenous leukemia (AML) is to prevent leukemia cells from coming back. (cancer.ca)
  • Treatment for AML carried out in two stages - the initial stage or induction stage to kill the leukemia cells of the bone marrow and the consolidation stage to kill any remaining leukemia cells that may be present in the body. (news-medical.net)
  • The following is a general overview of the treatment of the consolidation treatment options for acute myeloid leukemia. (texasoncology.com)
  • The closer together induction and consolidation are given, the lesser the chance of leukemia recurrence. (news-medical.net)
  • ZARXIO is indicated for reducing the time to neutrophil recovery and the duration of fever, following induction or consolidation chemotherapy treatment of patients with acute myeloid leukemia ( AML ) [see Clinical Studies ]. (rxlist.com)
  • Chemotherapy is the main treatment for nearly all people with acute lymphocytic leukemia (AML). (ahealthyme.com)
  • If there are still leukemia cells in your bone marrow, you may have a second course of chemotherapy. (ahealthyme.com)
  • PURPOSE: This phase II trial is studying how well giving combination chemotherapy works in treating patients with acute promyelocytic leukemia. (ichgcp.net)
  • The first two phases use intensive chemotherapy medications designed to kill the leukemia cells that grow quickly. (ucsfhealth.org)
  • Also, children with inherited immune system problems and children who have chemotherapy to treat some other types of cancer have an increased risk of developing leukemia. (baptisthealth.net)
  • Find out more about chemotherapy for childhood leukemia . (cancer.ca)
  • Chemotherapy normally works by killing cells that grow quickly, such as leukemia cells. (ahealthyme.com)
  • Children who get chemotherapy or radiation to treat other types of cancer have an increased risk of developing leukemia later on. (chop.edu)
  • Patients with acute leukemia who initially survive invasive fungal disease must receive chemotherapy or go on to transplant. (haematologica.org)
  • The objectives of this study were to assess the impact of invasive fungal diseases on the application of chemotherapy regimens in patients with acute leukemia surviving invasive fungal diseases, and the possible impact of these changes on the event-free (EFS) and overall survival (OS). (haematologica.org)
  • All acute leukemia patients aged 60 years or under were housed in laminar-air flow (LAF) rooms during the chemotherapy courses with an expected neutropenia of over ten days. (haematologica.org)
  • PRINCETON, N.J.--( BUSINESS WIRE )-- Bristol-Myers Squibb Company (NYSE:BMY) today announced the U.S. Food and Drug Administration (FDA) has expanded the indication for Sprycel ® (dasatinib) tablets to include the treatment of pediatric patients one year of age and older with newly diagnosed Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) in combination with chemotherapy. (businesswire.com)
  • This randomized phase II / III trial studies how well combination chemotherapy with or without rituximab works in treating younger patients with stage III-IV non-Hodgkin lymphoma or B-cell acute leukemia. (cancer.gov)
  • It is not yet known whether combination chemotherapy together with rituximab is more effective in treating patients with non-Hodgkin lymphoma or B-cell acute leukemia. (cancer.gov)
  • A bone marrow transplant begins with high doses of chemotherapy or radiation to destroy any leukemia-producing bone marrow. (mayoclinic.org)
  • Allogeneic stem cell transplant involves the transfer of stem cells from a healthy donor to the patient's body after intensive radiation or chemotherapy. (news-medical.net)
  • The investigators are looking to determine the highest dose of venetoclax that can be given safely in combination with these chemotherapy drugs. (clinicaltrials.gov)
  • In the expansion part of Phase 1 part, a maximum of 3 subjects will receive ASP2215 at RED that has been recommended in the dose-evaluation part and the safety will be assessed based on the onset of DLTs during Cycle 1 of the induction and consolidation periods. (centerwatch.com)
  • A DLT is defined as any Grade ≥ 3 non-hematologic or extramedullary toxicity or any events that require dose reduction of ASP2215 that occur during the DLT assessment period, and that is considered to be possibly, probably, or definitely related to induction or consolidation therapies including the study drugs. (clinicaltrials.gov)
  • After PBSC harvesting, high-dose chemotherapy of melphalan with auto-PBSCT was performed. (springer.com)
  • Consider dose escalation in increments of 5 mcg/kg for each chemotherapy cycle‚ according to the duration and severity of the absolute neutrophil count (ANC) nadir . (rxlist.com)
  • Another option may be very high-dose chemotherapy along with a stem cell transplant. (ahealthyme.com)
  • One way might be to increase the dose of chemotherapy. (cancerresearchuk.org)
  • In this study, we investigated the treatment outcomes and prognostic factors of high-dose methotrexate, vincristine, and procarbazine (MVP) chemotherapy followed by an interim response-adapted intensification strategy in immunocompetent patients with PCNSL. (yonsei.ac.kr)
  • Ten (25 %) patients who achieved complete response (CR) in the interim analysis did not receive any additional consolidation treatment after completion of planned high-dose MVP chemotherapy. (yonsei.ac.kr)
  • 2002 ). To improve the survival outcome, a number of therapeutic approaches have been tried, such as dose dense chemotherapy (Masutani et al. (springer.com)
  • 2000 ), high-dose chemotherapy (Leyvraz et al. (springer.com)
  • To improve the prognosis for patients with metastatic Ewing sarcoma/primitive neuroectodermal tumors (ES/PNET) using conventional chemotherapy and consolidation high-dose chemotherapy (HDCT) containing busulfan and melphalan. (ovid.com)
  • This stratified clinical and molecular treatment approach will be used to evaluate the following: - To find out if participants with low-risk WNT tumors can be treated with a lower dose of radiation to the brain and spine, and a lower dose of the chemotherapy drug cyclophosphamide while still achieving the same survival rate as past St. Jude studies with fewer side effects. (stanford.edu)
  • In addition, paclitaxel/cisplatin combination chemotherapy was demonstrated to have superior progression-free survival than platinum alone in some phase Ⅱ studies. (clinicaltrials.gov)
  • The event-free survival at three years for the nonrandomized intensive-chemotherapy group was 39 +/- 5.1 percent, and for a contemporaneous group of patients each of whom received a histocompatible bone marrow transplant from a sibling, it was 52 +/- 8.0 percent. (nih.gov)
  • 120 days) on survival among patients with stage I to III breast cancer treated with surgery and adjuvant chemotherapy from 2010 to 2014. (thefreedictionary.com)
  • our study shows that CRT with 5-FU and cisplatin, with or without consolidation chemotherapy, was well tolerated and proved highly encouraging in terms of long-term survival and the preservation of anal function in ASCC. (beds.ac.uk)
  • Several efforts have been tried to improve survival of patients who treated with neoadjuvant CRT and to achieve more pCR including adding cytotoxic chemotherapeutic agents, chronologic modification of chemotherapy schedule or adding chemotherapy during the perioperative period. (beds.ac.uk)
  • The progress in treatment and survival for patients with blood cancers is largely due to the development of chemotherapy drugs over the past 40 years. (lls.org)
  • Around 1980, several small trials demonstrated that adding chemotherapy after RT improved survival. (wikibooks.org)
  • The survival advantage conferred by adding oxaliplatin to adjuvant chemotherapy with fluorouracil (5-FU) in stage III colon cancer, as previously shown in patients in randomized controlled trials, extends to patients in the general population, including older and minority group patients and those. (ascopost.com)
  • In the study, Sprycel plus chemotherapy demonstrated a three-year event-free survival benefit. (businesswire.com)
  • A device surgically implanted beneath the scalp that is used to deliver chemotherapy drugs directly into the cerebrospinal fluid (CSF) around the brain and spinal cord. (cancer.ca)
  • A method of treating patients with repetitive, low doses of chemotherapy drugs over a longer period of time. (bcm.edu)
  • RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. (ichgcp.net)
  • Chemotherapy is the use of potent drugs or chemicals, often in combinations or intervals, to kill or damage cancer cells in the body. (lls.org)
  • Chemotherapy drugs are often called anticancer agents. (lls.org)
  • All chemotherapy drugs interfere with cancer cells' ability to grow or multiply. (lls.org)
  • That's why it's essential that the disease be accurately diagnosed: Certain chemotherapy drugs are used only for certain disease cell types. (lls.org)
  • Both new chemotherapy drugs and new ways to attack cancer cells continue to emerge as research progresses. (lls.org)
  • Many chemotherapy drugs attack cancer cells by interacting with the cancer cell's DNA or RNA (genetic makeup). (lls.org)
  • Some doctors believe it may be related to exposure to certain chemicals, radiation , and even drugs used for chemotherapy . (healthline.com)
  • Its intensity can be reduced by steroids, chemotherapy, proteasome inhibitors, immunomodulatory drugs such as thalidomide or lenalidomide, and stem cell transplants. (newsmaker.com.au)
  • Chemotherapy is given in 3 phases (induction, consolidation, and maintenance) using many chemo drugs. (cancer.org)
  • It is given as 3 phases of chemotherapy (induction, consolidation, and maintenance) using many drugs, and it lasts for about 2 years. (cancer.org)
  • Studies are being done to determine whether adding other drugs to chemotherapy might make treatment more effective. (cancer.org)
  • Treatment for these lymphomas usually consists of chemotherapy with 4 or more drugs given for about 3 to 6 months. (cancer.org)
  • He will get the standard chemotherapy that is treated the same way throughout the country, plus additonal treatment and drugs that are part of this study to further the research to lower the risk of the cancer coming back. (caringbridge.org)
  • In this type of treatment, chemotherapy drugs are often injected directly into the fluid that covers the spinal cord. (mayoclinic.org)
  • Chemotherapy drugs can also be used in the consolidation and maintenance phases. (mayoclinic.org)
  • 3-9 As shown in a randomized study, 9 simultaneous combination is more effective than sequential administration of ATRA and chemotherapy. (bloodjournal.org)
  • Children with APL get a non-chemotherapy drug similar to vitamin A called all-trans retinoic acid (ATRA) . (cancer.org)
  • This phase often includes giving all-trans retinoic acid (ATRA), which is similar to vitamin A. It is combined with standard chemotherapy. (stjude.org)
  • In this phase, ATRA, a drug known as arsenic trioxide and chemotherapy are given together. (stjude.org)
  • In this phase, ATRA is often given along with either a chemotherapy medicine and/ or with ATO. (ahealthyme.com)
  • This trial is to assess the efficacy and feasibility of consolidation chemotherapy after neoadjuvant chemoradiotherapy for locally advanced mid or low rectal cancer. (clinicaltrials.gov)
  • After neoadjuvant chemoradiotherapy, patients will receive surgery followed by eight cycles of chemotherapy. (clinicaltrials.gov)
  • After neoadjuvant chemoradiotherapy, patients will receive three cycles of chemotherapy. (clinicaltrials.gov)
  • Results: Of the 20 patients, 19 completed induction chemoradiotherapy and 13 completed consolidation. (elsevier.com)
  • Conclusion: Pemetrexed-cisplatin combined with TRT followed by consolidation pemetrexed was not superior to standard chemoradiotherapy for stage III unresectable nonsquamous non-small-cell lung cancer. (elsevier.com)
  • The objectives of this study were to evaluate long-term results of concurrent chemoradiotherapy (CRT) with 5-fluorouracil and cisplatin and the potential benefit of consolidation chemotherapy in patients with anal squamous cell carcinoma (ASCC). (beds.ac.uk)
  • The purpose of this study is to evaluate the outcomes of neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy followed by minimally invasive esophagectomy on patients with locally. (bioportfolio.com)
  • This differs from most standard chemotherapy treatments which are given at high doses for short periods of time. (bcm.edu)
  • A type of chemotherapy which is given intravenously (into a vein). (themmrf.org)
  • Bone marrow and stem cell transplants are an alternative option in patients who do not respond to chemotherapy. (news-medical.net)
  • Among all ovarian cancers, the worst prognosis is seen in ovarian clear cell carcinomas (OCCC) which typically don't respond to chemotherapy. (genengnews.com)
  • 2002 ). Patients with lower pretreatment circulating VEGF levels were more likely to respond to chemotherapy compared to those with higher levels of VEGF (Salven et al. (springer.com)
  • Depending on when the participant join the study, the participant may participate in part 1 (induction with venetoclax escalation), part 2 (consolidation with venetoclax escalation), or part 3 (an expansion cohort utilizing the maximum tolerated doses identified in parts 1 and 2). (clinicaltrials.gov)
  • You may get higher doses of chemotherapy medicines for several days. (ahealthyme.com)
  • Chemotherapy for AML is typically given in high doses. (ahealthyme.com)
  • A stem cell transplant that includes lower doses of chemotherapy and/or radiation than is standard. (bcm.edu)
  • Twenty-one (67.7%) received consolidation chemotherapy with the same doses of 5-fluorouracil and cisplatin, repeated every 4 weeks for maximum 4 cycles. (beds.ac.uk)
  • Compared with conventional chemotherapy, HDCT may yield benefits for patients with lung-only metastases or bone metastases. (ovid.com)
  • Patients who have a rapid reduction in the leukemic cells in the bone marrow within 7-14 days following multiagent chemotherapy have a better prognosis. (pediatriconcall.com)
  • A CR was achieved in 100% of patients with R/R HCL treated with the chemotherapy-free combination of vemurafenib plus rituximab. (clinicaloptions.com)
  • After recovery, intensification with natural product chemotherapy will be administered, consisting of four cycles of paclitaxel given as a 24-hour infusion followed by four cycles of single agent doxorubicin. (knowcancer.com)
  • Previously untreated Stage III or IV classical Hodgkin lymphoma (cHL), in combination with chemotherapy. (drugs.com)
  • Chemotherapy during this phase is given intravenously or orally in combination. (news-medical.net)
  • Giving more than one drug (combination chemotherapy) may kill more cancer cells. (ichgcp.net)
  • The efficacy of Sprycel tablets in combination with chemotherapy was evaluated in a single cohort of the Phase 2, multicenter, single-arm CA180-372 study, which included 78 pediatric patients with newly diagnosed B-cell precursor Ph+ ALL. (businesswire.com)
  • Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. (naver.com)
  • A higher percentage of radical resection is reported in studies using neoadjuvant chemotherapy followed by surgery versus surgery alone for esophageal cancer. (bioportfolio.com)
  • Some people with higher-risk disease may be given chemotherapy directly into the fluid that surrounds the spinal cord and brain. (mskcc.org)
  • KONCLUDE trial aims to investigate whether consolidation chemotherapy shows better pCR and 3-year DFS than adjuvant chemotherapy alone for the patients who received neoadjuvant CRT for locally advanced rectal cancer. (beds.ac.uk)
  • The chemotherapy and/or radiation given to patients as part of a stem cell transplant. (bcm.edu)
  • This type of stem cell transplant is most commonly used in situations where the patient has underlying conditions that might make the chemotherapy/radiation excessively toxic to them. (bcm.edu)
  • A stem cell transplant may also be used when ALL comes back after a second course of chemotherapy. (cancer.ca)
  • For AML with "good-risk" chromosome changes, additional chemotherapy or an autologous transplant is usually recommended. (bio-medicine.org)
  • Further trials with a larger patient population are warranted in order to evaluate the potential role of consolidation chemotherapy. (beds.ac.uk)
  • INTERPRETATION AND CONCLUSIONS: In this study, early consolidation seemed to improve the prognosis of children with LR-ALL, but differences in EFS were not significant. (haematologica.org)
  • Patients without progression underwent consolidation chemotherapy with etoposide and a platinum agent for one cycle followed by two cycles of docetaxel. (elsevier.com)
  • The purpose of this study is to determine the efficacy and safety of consolidation chemotherapy with paclitaxel plus cisplatin (2 cycles per 3 weeks) following radical hysterectomy and adjuvant chemoradiation (2 cycles per 4 weeks) for high risk early stage cervical cancer. (clinicaltrials.gov)
  • The purpose of this study is to determine whether docetaxel, cisplatin, and capecitabine (DCX) are effective as the neoadjuvant chemotherapy before esophagectomy in patients with loco-regi. (bioportfolio.com)
  • They will be randomized and assigned to undergo TME followed by 8 cycles of adjuvant chemotherapy (control arm) or receive 3 cycles of consolidation chemotherapy before TME, and receive 5 cycles of adjuvant chemotherapy (experimental arm). (beds.ac.uk)
  • Thereafter, they will receive surgery followed by five cycles of chemotherapy. (clinicaltrials.gov)
  • Patients will receive three cycles of chemotherapy (five if there is still residual tumor remaining after three cycles). (mskcc.org)
  • Consolidation chemotherapy is adding several cycles of chemotherapy between neoadjuvant CRT and TME. (beds.ac.uk)
  • Patients who had surgery to remove their cancer must begin induction chemotherapy within 4 weeks of the surgical procedure. (mskcc.org)
  • Chemotherapy uses anticancer medicines to kill cancer cells. (ahealthyme.com)
  • Chemotherapy medicines are designed to attack and kill cells that divide quickly, including cancer cells. (ahealthyme.com)
  • Chemotherapy refers to medicines that help fight cancer. (chop.edu)
  • Skeletal Muscle Loss during Neoadjuvant Chemotherapy Is an Independent Risk Factor for Postoperative Infectious Complications in Patients with Advanced Esophageal Cancer. (bioportfolio.com)
  • Neoadjuvant chemotherapy in local-regionally advanced nasopharyngeal carcinoma: A National Cancer Database analysis. (bioportfolio.com)
  • To evaluate the efficacy of maintenance apatinib after chemotherapy for extensive-stage (ED) small-cell lung cancer (SCLC). (springer.com)
  • A prospective, open-label phase 2 trial in metastatic pancreatic cancer subjects who have failed at least one line of any prior chemotherapy. (rochester.edu)
  • Chemotherapy for other forms of cancer. (encyclopedia.com)