PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Drosophila: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Antennapedia Homeodomain Protein: Antennapedia homeodomain protein is a homeobox protein involved in limb patterning in ARTHROPODS. Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA.Genes, Homeobox: Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY PATTERNING) and MORPHOGENESIS throughout development. Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS.Drosophila Proteins: Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.Drosophila melanogaster: A species of fruit fly much used in genetics because of the large size of its chromosomes.Nuclear Localization Signals: Short, predominantly basic amino acid sequences identified as nuclear import signals for some proteins. These sequences are believed to interact with specific receptors at the NUCLEAR PORE.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Subcellular Fractions: Components of a cell produced by various separation techniques which, though they disrupt the delicate anatomy of a cell, preserve the structure and physiology of its functioning constituents for biochemical and ultrastructural analysis. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p163)Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Cell Compartmentation: A partitioning within cells due to the selectively permeable membranes which enclose each of the separate parts, e.g., mitochondria, lysosomes, etc.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Euplotes: A genus of ciliate protozoa having a dorsoventrally flattened body with widely spaced rows of short bristle-like cilia on the dorsal surface.Micronucleus, Germline: The smaller, reproductive, transcriptionally inert nucleus in the cells of ciliate protozoans, as distinguished from the larger, vegetative, transcriptionally active MACRONUCLEUS. Micronuclei participate in MEIOSIS and autogamy during GENETIC CONJUGATION.Telomere: A terminal section of a chromosome which has a specialized structure and which is involved in chromosomal replication and stability. Its length is believed to be a few hundred base pairs.Ciliophora: A phylum of EUKARYOTES characterized by the presence of cilia at some time during the life cycle. It comprises three classes: KINETOFRAGMINOPHOREA; OLIGOHYMENOPHOREA; and POLYMENOPHOREA.Urochordata: A subphylum of chordates intermediate between the invertebrates and the true vertebrates. It includes the Ascidians.Ciona intestinalis: The only species of a cosmopolitan ascidian.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Chickens: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.Gene Duplication: Processes occurring in various organisms by which new genes are copied. Gene duplication may result in a MULTIGENE FAMILY; supergenes or PSEUDOGENES.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.ArchivesBiological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Software: Sequential operating programs and data which instruct the functioning of a digital computer.Exonucleases: Enzymes that catalyze the release of mononucleotides by the hydrolysis of the terminal bond of deoxyribonucleotide or ribonucleotide chains.Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Hydrogen Bonding: A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.Phospholipase D: An enzyme found mostly in plant tissue. It hydrolyzes glycerophosphatidates with the formation of a phosphatidic acid and a nitrogenous base such as choline. This enzyme also catalyzes transphosphatidylation reactions. EC 3.1.4.4.Post-Traumatic Headache: Secondary headache attributed to TRAUMA of the HEAD and/or the NECK.Sterol Esterase: An enzyme that catalyzes the hydrolysis of CHOLESTEROL ESTERS and some other sterol esters, to liberate cholesterol plus a fatty acid anion.Methanobacterium: A genus of anaerobic, rod-shaped METHANOBACTERIACEAE. Its organisms are nonmotile and use ammonia as the sole source of nitrogen. These methanogens are found in aquatic sediments, soil, sewage, and the gastrointestinal tract of animals.Haloferax mediterranei: A species of halophilic archaea found in the Mediterranean Sea. It produces bacteriocins active against a range of other halobacteria.Euryarchaeota: A phylum of ARCHAEA comprising at least seven classes: Methanobacteria, Methanococci, Halobacteria (extreme halophiles), Archaeoglobi (sulfate-reducing species), Methanopyri, and the thermophiles: Thermoplasmata, and Thermococci.Alcohol Oxidoreductases: A subclass of enzymes which includes all dehydrogenases acting on primary and secondary alcohols as well as hemiacetals. They are further classified according to the acceptor which can be NAD+ or NADP+ (subclass 1.1.1), cytochrome (1.1.2), oxygen (1.1.3), quinone (1.1.5), or another acceptor (1.1.99).Lactate Dehydrogenases: Alcohol oxidoreductases with substrate specificity for LACTIC ACID.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Molecular Dynamics Simulation: A computer simulation developed to study the motion of molecules over a period of time.Solutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Nuclear Magnetic Resonance, Biomolecular: NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Protein Structure, Secondary: The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.

The Drosophila kismet gene is related to chromatin-remodeling factors and is required for both segmentation and segment identity. (1/15406)

The Drosophila kismet gene was identified in a screen for dominant suppressors of Polycomb, a repressor of homeotic genes. Here we show that kismet mutations suppress the Polycomb mutant phenotype by blocking the ectopic transcription of homeotic genes. Loss of zygotic kismet function causes homeotic transformations similar to those associated with loss-of-function mutations in the homeotic genes Sex combs reduced and Abdominal-B. kismet is also required for proper larval body segmentation. Loss of maternal kismet function causes segmentation defects similar to those caused by mutations in the pair-rule gene even-skipped. The kismet gene encodes several large nuclear proteins that are ubiquitously expressed along the anterior-posterior axis. The Kismet proteins contain a domain conserved in the trithorax group protein Brahma and related chromatin-remodeling factors, providing further evidence that alterations in chromatin structure are required to maintain the spatially restricted patterns of homeotic gene transcription.  (+info)

A Drosophila doublesex-related gene, terra, is involved in somitogenesis in vertebrates. (2/15406)

The Drosophila doublesex (dsx) gene encodes a transcription factor that mediates sex determination. We describe the characterization of a novel zebrafish zinc-finger gene, terra, which contains a DNA binding domain similar to that of the Drosophila dsx gene. However, unlike dsx, terra is transiently expressed in the presomitic mesoderm and newly formed somites. Expression of terra in presomitic mesoderm is restricted to cells that lack expression of MyoD. In vivo, terra expression is reduced by hedgehog but enhanced by BMP signals. Overexpression of terra induces rapid apoptosis both in vitro and in vivo, suggesting that a tight regulation of terra expression is required during embryogenesis. Terra has both human and mouse homologs and is specifically expressed in mouse somites. Taken together, our findings suggest that terra is a highly conserved protein that plays specific roles in early somitogenesis of vertebrates.  (+info)

Telomerase reverse transcriptase gene is a direct target of c-Myc but is not functionally equivalent in cellular transformation. (3/15406)

The telomerase reverse transcriptase component (TERT) is not expressed in most primary somatic human cells and tissues, but is upregulated in the majority of immortalized cell lines and tumors. Here, we identify the c-Myc transcription factor as a direct mediator of telomerase activation in primary human fibroblasts through its ability to specifically induce TERT gene expression. Through the use of a hormone inducible form of c-Myc (c-Myc-ER), we demonstrate that Myc-induced activation of the hTERT promoter requires an evolutionarily conserved E-box and that c-Myc-ER-induced accumulation of hTERT mRNA takes place in the absence of de novo protein synthesis. These findings demonstrate that the TERT gene is a direct transcriptional target of c-Myc. Since telomerase activation frequently correlates with immortalization and telomerase functions to stabilize telomers in cycling cells, we tested whether Myc-induced activation of TERT gene expression represents an important mechanism through which c-Myc acts to immortalize cells. Employing the rat embryo fibroblast cooperation assay, we show that TERT is unable to substitute for c-Myc in the transformation of primary rodent fibroblasts, suggesting that the transforming activities of Myc extend beyond its ability to activate TERT gene expression and hence telomerase activity.  (+info)

Molecular phylogeny of the ETS gene family. (4/15406)

We have constructed a molecular phylogeny of the ETS gene family. By distance and parsimony analysis of the ETS conserved domains we show that the family containing so far 29 different genes in vertebrates can be divided into 13 groups of genes namely ETS, ER71, GABP, PEA3, ERG, ERF, ELK, DETS4, ELF, ESE, TEL, YAN, SPI. Since the three dimensional structure of the ETS domain has revealed a similarity with the winged-helix-turn-helix proteins, we used two of them (CAP and HSF) to root the tree. This allowed us to show that the family can be divided into five subfamilies: ETS, DETS4, ELF, TEL and SPI. The ETS subfamily comprises the ETS, ER71, GABP, PEA3, ERG, ERF and the ELK groups which appear more related to each other than to any other ETS family members. The fact that some members of these subfamilies were identified in early metazoans such as diploblasts and sponges suggests that the diversification of ETS family genes predates the diversification of metazoans. By the combined analysis of both the ETS and the PNT domains, which are conserved in some members of the family, we showed that the GABP group, and not the ERG group, is the one most closely related to the ETS group. We also observed that the speed of accumulation of mutations in the various genes of the family is highly variable. Noticeably, paralogous members of the ELK group exhibit strikingly different evolutionary speed suggesting that the evolutionary pressure they support is very different.  (+info)

A single membrane-embedded negative charge is critical for recognizing positively charged drugs by the Escherichia coli multidrug resistance protein MdfA. (5/15406)

The nature of the broad substrate specificity phenomenon, as manifested by multidrug resistance proteins, is not yet understood. In the Escherichia coli multidrug transporter, MdfA, the hydrophobicity profile and PhoA fusion analysis have so far identified only one membrane-embedded charged amino acid residue (E26). In order to determine whether this negatively charged residue may play a role in multidrug recognition, we evaluated the expression and function of MdfA constructs mutated at this position. Replacing E26 with the positively charged residue lysine abolished the multidrug resistance activity against positively charged drugs, but retained chloramphenicol efflux and resistance. In contrast, when the negative charge was preserved in a mutant with aspartate instead of E26, chloramphenicol recognition and transport were drastically inhibited; however, the mutant exhibited almost wild-type multidrug resistance activity against lipophilic cations. These results suggest that although the negative charge at position 26 is not essential for active transport, it dictates the multidrug resistance character of MdfA. We show that such a negative charge is also found in other drug resistance transporters, and its possible significance regarding multidrug resistance is discussed.  (+info)

A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing. (6/15406)

The assembly pathway of spliceosomal snRNPs in yeast is poorly understood. We devised a screen to identify mutations blocking the assembly of newly synthesized U4 snRNA into a functional snRNP. Fifteen mutant strains failing either to accumulate the newly synthesized U4 snRNA or to assemble a U4/U6 particle were identified and categorized into 13 complementation groups. Thirteen previously identified splicing-defective prp mutants were also assayed for U4 snRNP assembly defects. Mutations in the U4/U6 snRNP components Prp3p, Prp4p, and Prp24p led to disassembly of the U4/U6 snRNP particle and degradation of the U6 snRNA, while prp17-1 and prp19-1 strains accumulated free U4 and U6 snRNA. A detailed analysis of a newly identified mutant, the sad1-1 mutant, is presented. In addition to having the snRNP assembly defect, the sad1-1 mutant is severely impaired in splicing at the restrictive temperature: the RP29 pre-mRNA strongly accumulates and splicing-dependent production of beta-galactosidase from reporter constructs is abolished, while extracts prepared from sad1-1 strains fail to splice pre-mRNA substrates in vitro. The sad1-1 mutant is the only splicing-defective mutant analyzed whose mutation preferentially affects assembly of newly synthesized U4 snRNA into the U4/U6 particle. SAD1 encodes a novel protein of 52 kDa which is essential for cell viability. Sad1p localizes to the nucleus and is not stably associated with any of the U snRNAs. Sad1p contains a putative zinc finger and is phylogenetically highly conserved, with homologues identified in human, Caenorhabditis elegans, Arabidospis, and Drosophila.  (+info)

The highly conserved beta-hairpin of the paired DNA-binding domain is required for assembly of Pax-Ets ternary complexes. (7/15406)

Pax family transcription factors bind DNA through the paired domain. This domain, which is comprised of two helix-turn-helix motifs and a beta-hairpin structure, is a target of mutations in congenital disorders of mice and humans. Previously, we showed that Pax-5 (B-cell-specific activator protein) recruits proteins of the Ets proto-oncogene family to bind a composite DNA site that is essential for efficient transcription of the early-B-cell-specific mb-1 promoter. Here, evidence is provided for specific interactions between Ets-1 and the amino-terminal subdomains of Pax proteins. By tethering deletion fragments of Pax-5 to a heterologous DNA-binding domain, we show that 73 amino acids (amino acids 12 to 84) of its amino-terminal subdomain can recruit the ETS domain of Ets-1 to bind the composite site. Furthermore, an amino acid (Gln22) within the highly conserved beta-hairpin motif of Pax-5 is essential for efficient recruitment of Ets-1. The ability to recruit Ets proteins to bind DNA is a shared property of Pax proteins, as demonstrated by cooperative DNA binding of Ets-1 with sequences derived from the paired domains of Pax-2 and Pax-3. The strict conservation of sequences required for recruitment of Ets proteins suggests that Pax-Ets interactions are important for regulating transcription in diverse tissues during cellular differentiation.  (+info)

Analysis of a ubiquitous promoter element in a primitive eukaryote: early evolution of the initiator element. (8/15406)

Typical metazoan core promoter elements, such as TATA boxes and Inr motifs, have yet to be identified in early-evolving eukaryotes, underscoring the extensive divergence of these organisms. Towards the identification of core promoters in protists, we have studied transcription of protein-encoding genes in one of the earliest-diverging lineages of Eukaryota, that represented by the parasitic protist Trichomonas vaginalis. A highly conserved element, comprised of a motif similar to a metazoan initiator (Inr) element, surrounds the start site of transcription in all examined T. vaginalis genes. In contrast, a metazoan-like TATA element appears to be absent in trichomonad promoters. We demonstrate that the conserved motif found in T. vaginalis protein-encoding genes is an Inr promoter element. This trichomonad Inr is essential for transcription, responsible for accurate start site selection, and interchangeable between genes, demonstrating its role as a core promoter element. The sequence requirements of the trichomonad Inr are similar to metazoan Inrs and can be replaced by a mammalian Inr. These studies show that the Inr is a ubiquitous, core promoter element for protein-encoding genes in an early-evolving eukaryote. Functional and structural similarities between this protist Inr and the metazoan Inr strongly indicate that the Inr promoter element evolved early in eukaryotic evolution.  (+info)

Ultraconserved elements (UCEs), stretches of DNA that are identical between distantly related species, are enigmatic genomic features whose function is not well understood. First identified and characterized in mammals, UCEs have been proposed to play important roles in gene regulation, RNA processing, and maintaining genome integrity. However, because all of these functions can tolerate some sequence variation, their ultraconserved and ultraselected nature is not explained. We investigated whether there are highly conserved DNA elements without genic function in distantly related plant genomes. We compared the genomes of Arabidopsis thaliana and Vitis vinifera; species that diverged ∼115 million years ago (Mya). We identified 36 highly conserved elements with at least 85% similarity that are longer than 55 bp. Interestingly, these elements exhibit properties similar to mammalian UCEs, such that we named them UCE-like elements (ULEs). ULEs are located in intergenic or intronic regions and are ...
There are 481 segments longer than 200 base pairs (bp) that are absolutely conserved (100% identity with no insertions or deletions) between orthologous regions of the human, rat, and mouse genomes. Nearly all of these segments are also conserved in the chicken and dog genomes, with an average of 95 and 99% identity, respectively. Many are also significantly conserved in fish. These ultraconserved elements of the human genome are most often located either overlapping exons in genes involved in RNA processing or in introns or nearby genes involved in the regulation of transcription and development. Along with more than 5000 sequences of over 100 bp that are absolutely conserved among the three sequenced mammals, these represent a class of genetic elements whose functions and evolutionary origins are yet to be determined, but which are more highly conserved between these species than are proteins and appear to be essential for the ontogeny of mammals and other vertebrates.
Distribution of gene conservation across the Parcubacteria genomes. Shaded subsections represent degree of conservation across all genomes, with the lowest blac
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I am interested in determining if the secondary structure of several large (500bp+) sequences is conserved, with an ultimate goal of demonstrating greater divergence between the NTRs (the sequences here) versus ORFs between species. That is the coding regions have greater conservation than the non-coding. To do this I have been considering using the ViennaRNA services structure conservation analysis (SCA). However, after running the program I am finding the interpretation of the results not obvious to me.. The results can be found here: http://rna.tbi.univie.ac.at/cgi-bin/SCA.cgi?PAGE=3&ID=zwPrc7kAK8&r=36. For example the measure Basepair distance, pairwise provides a z-score of -7.045 with a p-value of zero. Obviously I can reject the null that my sequences are not different than the random sampling performed, but the sign of the value and how it related to conservation is where I am unsure. I pulled some of the papers they cite for the man pages of these programs and my thoughts are coming ...
Conservation has a cascading effect with numerous benefits, says a local biologist. Two entities in Stark County are furthering their missions of conservation in their own ways, but each wants to increase ties with the community and get people involved in conservation.
All references with links attached are the resources I used myself, other resources in plain black are additional resources.. References. Andolfatto, P. 2005. Adaptive evolution of non-coding DNA in Drosophila. Nature 437: 1149-1152.. Batten, D. 1998. Junk DNA (again). Creation Ex Nihilo Technical Journal 12: 5.. Beaton, M.J. and T. Cavalier-Smith. 1999. Eukaryotic non-coding DNA is functional: evidence from the differential scaling of cryptomonad genomes. Proceedings of the Royal Society of London, Series B 266: 2053-2059.. Bejerano, G., M. Pheasant, I. Makunin, S. Stephen, W.J. Kent, J.S. Mattick, and D. Haussler. 2004. Ultraconserved elements in the human genome. Science 304: 1321-1325.. Bennett, M.D. 1982. Nucleotypic basis of the spatial ordering of chromosomes in eukaryotes and the implications of the order for genome evolution and phenotypic variation. In Genome Evolution (eds. G.A. Dover and R.B. Flavell), pp. 239-261. Academic Press, New York.. Bergman, J. 2001. The functions of ...
Residue conservation is an important, established method for inferring protein function, modularity and specificity. It is important to recognize that it is the 3D spatial orientation of residues that drives sequence conservation. Considering this, we have built a new computational tool, VENN that allows researchers to interactively and graphically titrate sequence homology onto surface representations of protein structures. Our proposed titration strategies reveal critical details that are not readily identified using other existing tools. Analyses of a bZIP transcription factor and receptor recognition of Fibroblast Growth Factor using VENN revealed key specificity determinants. Weblink: http://sbtools.uchc.edu/venn/.
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Michael J. Conroy, John P. Carroll, Quantitative Conservation of Vertebrates 2009 | ISBN-10: 1405190981, 1405182288 | 352 pages | PDF | 5,4 MB This
It is suggested that parity conservation in the strong interactions may be a consequence of the bootstrap hypothesis. A model is presented to illustrate how this might come about. ...
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G-protein coupled receptors (GPCRs) belong to biologically important and functionally diverse and largest super family of membrane proteins. Co-clustered GPCRs from human and other genomes, organized as 32 clusters, were employed to study the amino acid conservation patterns and species-specific or cluster-specific motifs. Critical analysis on sequence composition and properties provide clues to connect functional relevance within and across genome for vast practical applications such as design of mutations and understanding of disease-causing genetic abnormalities. and GPCRs, leading to 32 clusters of eight major types as explained in our previous publication [9], we report the analysis of AAS and conserved motifs in all 32 492445-28-0 IC50 clusters of GPCRs. This 492445-28-0 IC50 study was further extended to a cross-genome analysis of and GPCRs. Methodology Physique 1 summarizes stepwise procedure for the identification of conserved AA (motifs) and residues exchanged at each position on MSA. ...
A gene is a locatable region of genomic sequence, corresponding to a unit of inheritance, which is associated with regulatory regions, transcribed regions and/or other functional sequence regions.[1][2] The physical development and phenotype of organisms can be thought of as a product of genes interacting with each other and with the environment.[3] A concise definition of a gene, taking into account complex patterns of regulation and transcription, genic conservation and non-coding RNA genes, has been proposed by Gerstein et al.[4] "A gene is a union of genomic sequences encoding a coherent set of potentially overlapping functional products". Colloquially, the term gene is often used to refer to an inheritable trait which is usually accompanied by a phenotype as in ("tall genes" or "bad genes") -- the proper scientific term for this is allele. In cells, genes consist of a long strand of DNA that contains a promoter, which controls the activity of a gene, and coding and non-coding sequence. ...
The highly-conserved Notch signaling pathway is unique, as both the Notch receptor and most of its respective ligands (canonically the DSL or Delta/Serrate/...
The Conservation Leadership through Learning (CLTL) program is a masters degree which prepares leaders to address complex conservation issues.
Pathway expression conservation and divergence. (a) Top conserved and (b) diverged pathway responses as revealed by the soft clustering approach. Each pathway i
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Evolutionary relationships among birds in Neoaves, the clade comprising the vast majority of avian diversity, have vexed systematists due to the ancient, rapid radiation of numerous lineages. We applied a new phylogenomic approach to resolve relationships in Neoaves using target enrichment (sequence capture) and high-throughput sequencing of ultraconserved elements (UCEs) in avian genomes. We collected sequence data from UCE loci for 32 members of Neoaves and one outgroup (chicken) and analyzed data sets that differed in their amount of missing data. An alignment of 1,541 loci that allowed missing data was 87% complete and resulted in a highly resolved phylogeny with broad agreement between the Bayesian and maximum-likelihood (ML) trees. Although results from the 100% complete matrix of 416 UCE loci were similar, the Bayesian and ML trees differed to a greater extent in this analysis, suggesting that increasing from 416 to 1,541 loci led to increased stability and resolution of the tree. Novel results
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AcylCoA binding protein (ACBP) is a highly-conserved protein found in the cells of all eukaryotes from yeast to humans. The protein binds activated fatt...
Download Thermodynamics, Conservation Of Energy notes PDF, DOC & PPT.This section provides the schedule of Thermodynamics, Conservation Of Energy lecture topics, lecture presentations
Vanhalst K، Kools P، Vanden Eynde E، van Roy F (2001). "The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number". FEBS Lett. 495 (1-2): 120-5. PMID 11322959. doi:10.1016/S0014-5793(01)02372-9. ...
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Transcription factors (TFs) regulate gene transcription and play pivotal roles in various biological processes such as development, cell cycle progression, cell differentiation and tumor suppression. Identifying cis-regulatory elements associated with TF-encoding genes is a crucial step in understanding gene regulatory networks. To this end, we have used a comparative genomics approach to identify putative cis-regulatory elements associated with TF-encoding genes in vertebrates. We have created a database named TFCONES (T ranscription F actor Genes & Associated CO nserved N oncoding E lementS) ( http://tfcones.fugu-sg.org ) which contains all human, mouse and fugu TF-encoding genes and conserved noncoding elements (CNEs) associated with them. The CNEs were identified by gene-by-gene alignments of orthologous TF-encoding gene loci using MLAGAN. We also predicted putative transcription factor binding sites within the CNEs. A significant proportion
Strategic Habitat Conservation Final Report of the National Ecological Assessment Team Forest Breeding Bird DST July 2006 Strategic Habitat Conservation A Report from the National Ecological Assessment Team ~ June 29, 2006 ~ 1 2 TABLE OF CONTENTS Preface Executive Summary Chapter I. The Changing Nature of Conservation Introduction The Catalysts of Change The Science and Practice of Conservation Thriving Amidst Change Chapter II. The Strategic Habitat Conservation Framework Introduction Strategic Habitat Conservation - A Tool, Not a Rule Element 1 - Biological Planning Element 2 - Conservation Design Element 3 - Conservation Delivery Element 4 - Monitoring and Research Chapter III. Building Joint Capability for the FWS and USGS A Direction for Change Strengthening Institutional Relationships Strengthening Operational Relationships Chapter IV. Recommendations Introduction Recommended Actions Glossary Appendix A The National Ecological Assessment Team Charter Appendix B Draft MOU between the FWS ...
Strategic Habitat Conservation Final Report of the National Ecological Assessment Team Forest Breeding Bird DST July 2006 Strategic Habitat Conservation A Report from the National Ecological Assessment Team ~ June 29, 2006 ~ 1 2 TABLE OF CONTENTS Preface Executive Summary Chapter I. The Changing Nature of Conservation Introduction The Catalysts of Change The Science and Practice of Conservation Thriving Amidst Change Chapter II. The Strategic Habitat Conservation Framework Introduction Strategic Habitat Conservation - A Tool, Not a Rule Element 1 - Biological Planning Element 2 - Conservation Design Element 3 - Conservation Delivery Element 4 - Monitoring and Research Chapter III. Building Joint Capability for the FWS and USGS A Direction for Change Strengthening Institutional Relationships Strengthening Operational Relationships Chapter IV. Recommendations Introduction Recommended Actions Glossary Appendix A The National Ecological Assessment Team Charter Appendix B Draft MOU between the FWS ...
The Conservation Register holds detailed information on conservation-restoration practices from across the UK and Ireland. The operation of the Conservation Register is guided by an Advisory Board
Jalview 2.10.1 is now available from www.jalview.org. This is a minor release in the 2.10 series, and brings a range of bug fixes and minor new features including batch BioJS HTML page generation, interactive selection from structure highlights, and alignment conservation analysis. Jalview 2.10.1 is also significantly more memory efficient when working with very wide alignments.. With the release of Jalview 2.10.1, we also welcome Kira Mourão to the Jalview Authors. Kira joined Jalviews core development team in October 2016, and this is the first release to include her contributions.. As usual, please get in contact via our email lists or issue tracker if you have bugs, issues, new features or want to contribute to Jalviews development !. ...
Jalview 2.10.1 is now available from www.jalview.org. This is a minor release in the 2.10 series, and brings a range of bug fixes and minor new features including batch BioJS HTML page generation, interactive selection from structure highlights, and alignment conservation analysis. Jalview 2.10.1 is also significantly more memory efficient when working with very wide alignments.. With the release of Jalview 2.10.1, we also welcome Kira Mourão to the Jalview Authors. Kira joined Jalviews core development team in October 2016, and this is the first release to include her contributions.. As usual, please get in contact via our email lists or issue tracker if you have bugs, issues, new features or want to contribute to Jalviews development !. ...
A group of conservation-minded farmers in the Sheboygan River watershed practice no-till, planting into green to boost soil health.
The Iowa Power Farming Show in Des Moines has about seven acres of floor space dedicated to the latest farm technology, but some of its devoted to a subject thats old as dirt. Healthy soils normally contain abundant organic matter, which aids in proper drainage and infiltration of water.
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Alamo Resource Conservation & Development Area Inc - View photos and videos of Alamo Resource Conservation & Development Area Inc on GreatNonprofits.org by staff, volunteers, donors and clients.
The local offices of the U.S. Department of Agriculture, the Natural Resources Conservation Service and the Eastern Connecticut Conservation District
One provision in the conservation title of the new Farm Bill re-couples federal crop insurance with conservation compliance, but only on highly erodible ground or wetlands.
S. 754. A bill to encourage partnerships among public agencies and other interested parties to promote fish conservation, and for other purposes. In GovTrack.us, a database of bills in the U.S. Congress.
The Conservation Gateway is for the conservation practitioner, scientist and decision-maker. Here we share the best and most up-to-date information we use to inform our work at The Nature Conservancy.
I have analysed the functions of a novel, conserved metalloprotease named Invadolysin, previously reported by the Heck laboratory to be involved in mitosis and cell migration. I carried out a second site non-complementation screen in Drosophila melanogaster to identify the interactors of Invadolysin utilizing the availability of a collection of genome-wide deficiency stocks. As a result of this screen, I identified non-stop, a ubiquitin protease, as a genetic interactor of invadolysin. I characterized similar mutant phenotypes of invadolysin and non-stop and showed that the abnormal chromosomal architecture observed in both mutants might be a result of histone ubiquitination. I also investigated the involvement of Invadolysin in Notch pathway. The Notch extracellular domain levels were normal in the invadolysin mutants, but the intracellular domain levels were greatly reduced suggesting that the Notch pathway was inactive, or compromised. The levels of the Notch ligand Delta were abnormally high ...
Aberrant pre-mRNA splicing can be more detrimental to the function of a gene than changes in the length or nature of the encoded amino acid sequence. Although predicting the effects of changes in consensus 5 and 3 splice sites near intron:exon boundaries is relatively straightforward, predicting the possible effects of changes in exonic splicing enhancers (ESEs) remains a challenge. As an initial step toward determining which ESEs predicted by the web-based tool ESEfinder in the breast cancer susceptibility gene BRCA1 are likely to be functional, we have determined their evolutionary conservation and compared their location with known BRCA1 sequence variants. Using the default settings of ESEfinder, we initially detected 669 potential ESEs in the coding region of the BRCA1 gene. Increasing the threshold score reduced the total number to 464, while taking into consideration the proximity to splice donor and acceptor sites reduced the number to 211. Approximately 11% of these ESEs (23/211) either are
0377]Accili, D. A note of caution on the Knockout Mouse Project. Nat Genet 36, 1132 (2004). [0378]Adams, D. J. et al. A genome-wide, end-sequenced 129Sv BAC library resource for targeting vector construction. Genomics 86, 753-8 (2005). [0379]Adams, D. J. et al. Mutagenic insertion and chromosome engineering resource (MICER). Nat Genet 36, 867-71 (2004). [0380]Angrand, P. O., Daigle, N., van der Hoeven, F., Scholer, H. R. & Stewart, A. F. Simplified generation of targeting constructs using ET recombination. Nucleic Acids Res 27, e16 (1999). [0381]Austin, C. P. et al. The knockout mouse project. Nat Genet 36, 921-4 (2004). [0382]Auwerx, J. et al. The European dimension for the mouse genome mutagenesis program. Nat Genet 36, 925-7 (2004). [0383]Baudin, A., Ozier-Kalogeropoulos, O., Denouel, A., Lacroute, F. & Cullin, C. A simple and efficient method for direct gene deletion in Saccharomyces cerevisiae. Nucleic Acids Res 21, 3329-30 (1993). [0384]Bejerano, G. et al. Ultraconserved elements in the ...
Errk. Make that Archelosauria... On Mon, Nov 17, 2014 at 8:14 AM, Ben Creisler ,[email protected], wrote: , Some buzz on Twitter about this paper today, which creates the , Achelosauria. The paper is now in open access but is still in , manuscript form. , , , , On Tue, Nov 4, 2014 at 8:31 AM, Ben Creisler ,[email protected], wrote: ,, Ben Creisler ,, [email protected] ,, ,, ,, A new online paper: ,, ,, Nicholas G. Crawford, James F. Parham, Anna B. Sellas, Brant C. ,, Faircloth, Travis C. Glenn, Theodore J. Papenfuss, James B. Henderson, ,, Madison H. Hansen & W. Brian Simison (2014) ,, A phylogenomic analysis of turtles. ,, Molecular Phylogenetics and Evolution (advance online publication) ,, DOI: 10.1016/j.ympev.2014.10.021 ,, http://www.sciencedirect.com/science/article/pii/S1055790314003819 ,, ,, ,, Highlights ,, ,, 2,004 Ultraconserved element (UCE) loci resolve relationships among ,, living turtles. ,, The UCE phylogeny is used to test and development a phylogenetic ,, nomenclature. ...
Cross-species comparison revealed that conservation of NF-κB family - related TFBS motifs is much higher in the Early genes group than in the Late genes group. The highest numbers of common DNA binding motifs considered were found in the locations where the adjusted promoter sequences were highly conserved. For almost all Early genes, the NF-κB-family related TFBS motifs were conserved between most pairs of species, with the exception of comparison between mouse and cattle in TNF. As we presumed the best promoter sequence conservation and interspecies conservation of TF binding motifs persisted between human and chimp, followed in many cases by that between human and cattle. In the case of two Early genes, REL and TNFAIP3 comparison, no conserved NF-κB-family related TFBS were found between chimpanzee or mouse and cattle. In human versus cattle comparison two single non-overlapping binding sites were found, but this is a low score in comparison with the number of conserved TFBS found in other ...
Compared to protein-coding sequences, the evolution of noncoding sequences and the selective constraints placed on these sequences is not well characterized. To compare the evolution of coding and noncoding sequences, we have conducted a survey for DNA polymorphism at five randomly chosen loci among …
Background Oligodendrocytes are specialized cells from the anxious system that make the myelin sheaths encircling the axons of neurons. sequences in the lengthy exercises of adjacent non-coding DNA that flank predicated on a combined mix of bioinformatics metrics that included evolutionary conservation across multiple vertebrate genomes the current presence of potential transcription aspect binding sites as well as the lifetime of ultraconserved components. Among our computational predictions carries a area previously defined as the basal promoter recommending our criterion symbolized features of known regulatory locations. Within this research we examined one applicant regulatory area for its capability to modulate the basal promoter and discovered that it represses appearance in undifferentiated embryonic stem cells. Conclusions/Significance The regulatory area we discovered modifies the appearance regulated with the basal promoter in a way in keeping with our current knowledge of appearance ...
It has been quite some time since the last update to the Quotes of interest series on junk DNA. Most of the posts have sought to demonstrate that the exhausting cliché that scientists dismissed possible functions for non-coding DNA until recently is false. Therefore, I have provided many quotes indicating that many (if not most) biologists continued to consider possible functions for various non-coding elements throughout the mythical period of neglect. This time, I want to discuss an example in which a particular kind of non-coding sequence was considered as probably non-functional - but because of knowledge about its biology, not because no function could be imagined.. The elements under discussion are endogenous retroviruses (ERVs) which, as the name suggests, are viral-like sequences that exist within the genome. Depending on who you ask, they are either very similar to or are interchangeable with long terminal repeat (LTR) retrotransposons. ERVs make up approximately 8% of the human ...
The U.S. Fish and Wildlife Service and the NOAA Fisheries are actively working to engage conservation partners and the public in the search for improved and innovative ways to conserve and protect imperiled species, even before they are listed under the Endangered Species Act (ESA).. The agencies are committed to strengthening the delivery of voluntary conservation tools, such as Candidate Conservation Agreements with Assurances (CCAA), by making it easier to work together on conservation efforts, thus are soliciting public review and comment on whether to revise the existing CCAA policy and accompanying regulations.. Candidate Conservation Agreements with Assurances are designed to provide an incentive to landowners to implement specific conservation measures for declining species that are not currently listed under the ESA. To participate in a CCAA, non-federal property owners can voluntarily implement specific conservation measures that reduce or eliminate threats on their land to species ...
Definition of conservation of energy in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is conservation of energy? Meaning of conservation of energy as a legal term. What does conservation of energy mean in law?
Up until relatively recently, researchers believed that the non-coding DNA sequences in the genomes of living things, including the human genome, had little, if any, function at all. Indeed, this non-coding DNA was often referred to as
Crystal Divers had a massive push for Shark Conservation and collected over 1000 signatures for the Project Aware shark conservation petition! An enormous thankyou to all of our staff, interns, divemaster trainees and IDC candidates for making a huge effort to help Project Aware to protect our Sharks!
What do you think of when you hear the term conservation? Admittedly the first things that jumps to my mind are trail work and invasive species removal because thats all Ive known for so many years.
Our Dimmable LEDs are compatible with many popular switches. To view switches that will work for your bulbs Download a Dimmer Compatibility Guide. ...
The SFLD is a database links evolutionarily related sequences and structures from mechanistically diverse superfamilies of enzymes to their chemical reactions.
The SFLD is a database links evolutionarily related sequences and structures from mechanistically diverse superfamilies of enzymes to their chemical reactions.
Vegetarian, nature lover, wildlife enthusiast and more than a little obsessive when it comes to conservation, Hollie enjoys writing about the...
Andolfatto took a different approach toward identifying functional non-coding sequences. He looked at coding and non-coding sequences from twelve D. melanogaster individuals and one D. simulans individual from the X-chromosome. He divided the non-coding sequences into 5 classes: 5 UTRs, 3 UTRs, introns, intergenic sequences within 2kb of a gene, and intergenic sequences more than 4kb from a gene. He then calculated a variety of population genetics statistics based on these sequences to determine if any of the non-coding DNA displays signatures of natural selection. I would expect that the UTRs (sequences that are transcribed, but not translated) are under more functional constraint than the intergenic regions and probably also display more signatures of positive selection. I also would expect that the introns would be constrained and have more evidence of positive selection (due to regulatory elements located within), and that the intergenic sequences located closer to genes are under more ...
This track shows multiple alignments of 100 vertebrate species and measurements of evolutionary conservation using two methods (phastCons and phyloP) from the PHAST package, for all species. The multiple alignments were generated using multiz and other tools in the UCSC/Penn State Bioinformatics comparative genomics alignment pipeline. Conserved elements identified by phastCons are also displayed in this track. PHAST/Multiz are built from chains ("alignable") and nets ("syntenic"), see the documentation of the Chain/Net tracks for a description of the complete alignment process. PhastCons is a hidden Markov model-based method that estimates the probability that each nucleotide belongs to a conserved element, based on the multiple alignment. It considers not just each individual alignment column, but also its flanking columns. By contrast, phyloP separately measures conservation at individual columns, ignoring the effects of their neighbors. As a consequence, the phyloP plots have a less smooth ...
This track shows multiple alignments of 100 vertebrate species and measurements of evolutionary conservation using two methods (phastCons and phyloP) from the PHAST package, for all species. The multiple alignments were generated using multiz and other tools in the UCSC/Penn State Bioinformatics comparative genomics alignment pipeline. Conserved elements identified by phastCons are also displayed in this track. PHAST/Multiz are built from chains ("alignable") and nets ("syntenic"), see the documentation of the Chain/Net tracks for a description of the complete alignment process. PhastCons is a hidden Markov model-based method that estimates the probability that each nucleotide belongs to a conserved element, based on the multiple alignment. It considers not just each individual alignment column, but also its flanking columns. By contrast, phyloP separately measures conservation at individual columns, ignoring the effects of their neighbors. As a consequence, the phyloP plots have a less smooth ...
This track shows multiple alignments of 100 vertebrate species and measurements of evolutionary conservation using two methods (phastCons and phyloP) from the PHAST package, for all species. The multiple alignments were generated using multiz and other tools in the UCSC/Penn State Bioinformatics comparative genomics alignment pipeline. Conserved elements identified by phastCons are also displayed in this track. PHAST/Multiz are built from chains ("alignable") and nets ("syntenic"), see the documentation of the Chain/Net tracks for a description of the complete alignment process. PhastCons is a hidden Markov model-based method that estimates the probability that each nucleotide belongs to a conserved element, based on the multiple alignment. It considers not just each individual alignment column, but also its flanking columns. By contrast, phyloP separately measures conservation at individual columns, ignoring the effects of their neighbors. As a consequence, the phyloP plots have a less smooth ...
Leading the Way in Wildlife Conservation One of the largest zoo-based conservation and science programs in the country, Lincoln Park Zoos Conservation & Science Department is dedicated to improving animal management and wildlife conservation. Zoo scientists combine expertise in a range of disciplines to identify threats to zoo and wild populations and develop strategies to ensure their continued existence.
... From Newtons third law of motion we can know about the conservation principle of momentum. Principle of conservation of momentum is equally applicable for all bodies- small or large, earthly or terrestrial. From Newtons first law of motion we know that if net applied force on a
Le laboratoire de la conservation des matériaux organiques (Département de la Conservation des antiquités et des œuvres dart - TEI dAthènes) cherche toujours à améliorer léducation en donnant aux étudiants des cycles supérieurs la possibilité de participer à des projets internationaux de recherche et dinnovation. Ce document analyse les objectifs éducatifs et les acquis dapprentissage des mesures susmentionnées et présente les résultats dune enquête réalisée par des questionnaires adressés aux étudiants.
The relentless exploitation and unsustainable use of wildlife, whether for food, medicine or other uses, is a key concern for conservationists worldwide. Indeed, wildlife conservation and sustainable use have recently become centrepieces in conservation and development research.
Government departments and statutory bodies of use to people responsible for the conservation, restoration and repair of historic buildings and places
Now, I gotta tell you, if youre thinking "But how can you GAINZZZ muscle when youre not taking in protein for one or several days at a time?," Im wondering the same damn thing.. He says that in long fasts, the body goes into Protein Conservation Mode, and stops shitting out old protein, instead keeping it within the body for recycling into newly needed proteins. Obviously, at some point, you have to take in protein if you want to GAINZZZ MAZZZ. And also, that Protein Conservation Mode seems to happen, if I have this right, after like 4 or 5 days. (I have previously read that the weightlifters worries about catabolisis -- muscle-eating, when no protein is available -- is overstated and does not happen for a day or two.). So honestly, I dont really understand this myself. I guess maybe I can fast until a lifting day then eat extra protein post-workout? Thus having the protein available when my HGH is still kind of high?. I dont know.. The other thing Im doing this for is that supposedly on ...
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We present a method for prediction of functional sites in a set of aligned protein sequences. The method selects sites which are both well conserved and clustered together in space, as inferred from the 3D structures of proteins included in the alignment. We tested the method using 86 alignments from the NCBI CDD database, where the sites of experimentally determined ligand and/or macromolecular interactions are annotated. In agreement with earlier investigations, we found that functional site predictions are most successful when overall background sequence conservation is low, such that sites under evolutionary constraint become apparent. In addition, we found that averaging of conservation values across spatially clustered sites improves predictions under certain conditions: that is, when overall conservation is relatively high and when the site in question involves a large macromolecular binding interface. Under these conditions it is better to look for clusters of conserved sites than to ...
Briefly, this freely-available tool performed a multiple sequence alignment of the input sequence and based on this alignment assigned residues a conservation score of 1 to 10. The structure of reduced OhrR (colored based on the output of this server) is available to the left with residues colored similar to output script files from ConSurf. Red spheres indicates the most highly conserved residues (10). Bright pink spheres indicate highly conserved residues (9). Light pink spheres indicate residues that are highly conserved but are more likely to substitution than those colored in bright pink. The most conserved region of OhrR Xc is the helix-turn-helix region. This is not surprising in that this is a transcription factor and if it is unable to bind DNA, then this function has been severely inhibited. What was surprising, however, is that the reactive cysteine (C22) of the protein and the residues it interacted with (C127) were not highly conserved. The conservation score for C22 was 7 (out of ...
Scientists in the USA have found a novel noncoding gene that alters proliferation in cancer cells to help tumour development.. The team, at the University of Michigan in Ann Arbor, identified THOR (Testis-associated Highly-conserved Oncogenic long noncoding RNA) while investigating an unexplored area of the genome harbouring a class of genes called long non-coding RNAs (ribonucleic acid) (lncRNAs). These genes do not contain information to make proteins, therefore they have long been regarded as junk DNA. More recently, non-coding regions of the genome have proved to have diverse functions in health and disease.. The study, published in Cell, demonstrates that the newly discovered non-coding gene is highly conserved in different species, including humans, mice and zebrafish. Genes that are evolutionarily conserved are likely important for biological processes. The fact that we found THOR to be a highly conserved IncRNA was exciting, said Dr Arul Chinnaiyan, who led the team.. When the ...
Nonsense-mediated mRNA decay (NMD) is a cellular RNA surveillance systemthat recognizes transcripts with premature termination codons and degradesthem. We previously discovered large numbers of natural alternative spliceforms that appear to be targets for NMD, and we speculated that this mightbe a mode of gene regulation which we termed RUST (regulated unproductivesplicing and
OKLAHOMA CONSERVATION COMMISSION CONSERVATION COST-SHARE PROGRAM Locally Led - Program Year 12 Allocation Period: December 7, 2009 - June 30, 2010 Program Year Completed: June 30, 2011 PREPARED BY OKLAHOMA CONSERVATION COMMISSION CONSERVATION PROGRAMS DIVISION This publication is issued by the Oklahoma Conservation Commission as authorized by Mike Thralls, executive director. Copies have not been printed but are available through the agency website, http:/conservation.ok.gov. BY AREA AREA I AMOUNT AMOUNT UNOBLIGATED ALLOCATED OBLIGATED AMOUNT DISTRICT PY 12 PY 12 PY 12 Alfalfa $ 20,500.00 $ 13,174.03 $ 7,325.97 Beaver $ 20,500.00 $ 20,683.96 $ (183.96) Blaine $ 12,300.00 $ 12,241.25 $ 58.75 Central North Canadian River $ 10,250.00 $ 10,000.00 $ 250.00 Cimarron County $ 12,300.00 $ 9,305.00 $ 2,995.00 Cimarron Valley $ 16,400.00 $ 4,755.00 $ 11,645.00 Dewey $ 20,500.00 $ 20,500.00 $ - East Canadian $ 12,300.00 $ 12,036.09 $ 263.91 East Woods $ 12,300.00 $ 9,730.00 $ 2,570.00 Ellis $ 20,500.00 $ ...
Sequence Conservation Within and Among Genomes:Quantitative Evolutionary, Comparative, and Biomedical Genomics The Units research is aimed at development of theoretical and computational tools for decoding genome sequences. We are especially interested on the impact of linkage, recombination, and epistasis on sequence conservation, and how they affect inference of selective pressure.
It is the relationship between the gene and the endo-environment of the organism, which it participates in the creation of, that mediates the activity of the gene. The study of the gene must also include the study of all that might happen the gene, which is a set of possibilities constrained and shaped by the organisms internal environment, which in turn is mediated by its external environment. Furthermore, the expression of the gene is moderated by the non-coding DNA in the chromosomes of the organisms (which may act as an analogue for the systems of organisation between people if we continue to stretch the metaphor) thus we can imagine contrasting mutations in the non-coding DNA with cultural adaptations, and imagine them also diffusing across the boundaries of societies, regulating the activities of people, who are akin to individual genes, in the Neo-Darwinian frame ...
NEGATIVE- When two colored bands appear on the membrane and one band appears in the control region (C) and another band appears in the test region (T).. Certain lines may appear lighter or thinner than other lines.. Each line is to be considered a clear reading whether it be faint, light or dark.. POSITIVE- When only one colored band appears in the control region (C). No apparent colored band appears in the test region (T).. INVALID RESULT- An invalid result is when a control band completely fails to appear.. ...
Whats the deal with animal biotechnology? From Eric Hallerman, PhD, Professor and Head of the Department of Fish and Wildlife Conservation at Virginia Tech University:
The purpose of CCA is to advise and educate the public on conservation of marine resources. The objective of CCA is to conserve, promote, and enhance the present and future availability of those coastal resources for the benefit and enjoyment of the general public.
Hard-working pupils from Clavering Primary School have battled through the elements to complete conservation work in a Hartlepool park.
by Elio | An exome is the collection of exons, the sequences within the primary mRNA transcripts of an organism that are eventually used for making proteins. The rest, non-coding sequences, called introns, are removed by RNA splicing. (Note that there is no introme, at least not yet.)
Buy Lineco Edinborough Archival Conservation Mounting Board (22 x 28", 2-Ply, Soft White, 25-Pack) featuring 2-Ply Archival Board, Made from Purified Alpha Cellulose Fiber Buffered with 3% Calcium Carbonate. Review Lineco
The red kite is subject to the longest continuous conservation project in the world. The RSPB is thought to have been involved continuously since 1905. Read more
Mount Kenya Environmental Conservation is active and undertakes projects in the following fields of work: Reforestation, and water catchment rehabilitation,
US – An environmental law will slow the adoption of conservation practices on farms, the House Agriculture Subcommittee heard last week.
1. MEET.5.1:Motif Element Estimation Tools - MEET 5.1 is an R-package that includes a set of models, aprox. 550, and tools for the detection of cis-regulatory sequences ...
Jan 26, 2016 - Session 3 Exploration of Models in A Story of Units Time: 30 minutes each Description Examine and practice use of models as they appear in A Story of Units. Numbers Through 10 (Number Towers, Number ...
BirdLife is the world leader in Bird Conservation. Rigorous science and projects in important sites and habitats for the conservation of birds and all nature.
IUCN Patron of Nature, Salley Ranney, accompanied by businessman, environmentalist and philanthropist Ted Turner, paid a recent visit to IUCNs office in...
London Life Coach & Relationship Expert Sloan Sheridan-Williams writes about the Voluntour package from STA Travel. This time we look at elephant conservation in Sri Lanka.
Class I has two highly conserved sequence motifs. It aminoacylates at the 2'-OH of a terminal adenosine nucleotide on tRNA, and ... Class II has three highly conserved sequence motifs. It aminoacylates at the 3'-OH of a terminal adenosine on tRNA, and is ... This new domain's functionality is conserved from that point on.[13] Application in biotechnology[edit]. In some of the ... For instance, one can start with the gene for a protein that binds a certain sequence of DNA, and, by directing an unnatural ...
The MADS box is a conserved sequence motif. The genes which contain this motif are called the MADS-box gene family.[1] The MADS ... The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box.[2] MADS-domain proteins ... MEF2-like MADS-domain proteins in animals and fungi have the MEF2 domain as a second conserved domain.[14] In plants, the MEF2- ... There is evidence that the MADS domain evolved from a sequence stretch of a type II topoisomerase in a common ancestor of all ...
Its sequences is highly conserved in different vertebrate species. SPP cleaves remnant signal peptides left behind in membrane ... It is an intramembrane aspartyl protease with the conserved active site motifs 'YD' and 'GxGD' in adjacent transmembrane ... as well as proteins with homologous leader sequences that are essential components of the general secretion pathway found in a ...
There is a conserved sequence in roughly three quarters of all ORs. This is a tripodal metal-ion binding site,[15] and Suslick ... The primary gene sequences for thousands of olfactory receptors are known for the genomes of more than a dozen organisms. They ...
"Evolutionary placement of Xanthomonadales based on conserved protein signature sequences". Mol Phylogenet Evol. 54 (2): 524-34 ... 2005). "The genome sequence of Xanthomonas oryzae pathovar oryzae KACC10331, the bacterial blight pathogen of rice". Nucleic ... Chen J, Xie G, Han S, Chertkov O, Sims D, Civerolo EL (2010). "Whole genome sequences of two Xylella fastidiosa strains (M12 ... The families can be distinguished from one another on the basis of conserved signature indels found among a variety of proteins ...
... they are not conserved in transcription. In other words, even when the sequence of a human lncRNA is conserved in another ... Large-scale sequencing of cDNA libraries and more recently transcriptomic sequencing by next generation sequencing indicate ... Initial studies into lncRNA conservation noted that as a class, they were enriched for conserved sequence elements, depleted in ... November 2006). "In vivo enhancer analysis of human conserved non-coding sequences". Nature. 444 (7118): 499-502. Bibcode: ...
All family members contain one or more repeats of the conserved amino acid sequence: CX7CX4-5CX10-13CXCX8GXRC ... This sequence contains 6 cysteine residues that form three intramolecular disulfide bonds. Disulfide bond formation generates ...
"Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences". Gene. 294 (1-2): 35-44. ... 2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40-5. doi:10.1038/ ... The ZNF366 gene was first identified in a DNA comparison study between 85 kb of Fugu rubripes sequence containing 17 genes with ... "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A ...
Its amino acid sequence is highly conserved in eukaryotes, differing by only a few residues. In more than thirty species, 34 of ... Many higher-order organisms possess a chain of 104 amino acids.[9] The sequences of cytochrome c in humans is identical to that ... Ambler RP (May 1991). "Sequence variability in bacterial cytochromes c". Biochimica et Biophysica Acta. 1058 (1): 42-7. doi: ... Amino acid sequences in cytochrome c proteins from different species, adapted from Strahler, Arthur; Science and Earth History ...
The conserved stem-loop was predicted within the HBV PRE sequence and confirmed by mutagenesis.[1][2] ... "The hepatitis B virus post-transcriptional regulatory element contains two conserved RNA stem-loops which are required for ...
Conserved sequence Ott, Alban; Idali Anouar; Marchais Antonin; Gautheret Daniel (Jan 2012). "NAPP: the Nucleic Acid ... The Nucleic acid phylogenetic profiling (NAPP) is a database of coding and non-coding sequences according to their pattern of ...
A highly conserved sequence (. . .PRCGXPD. . .) is present in the propeptide. Removal of the propeptide by proteolysis results ... The hemopexin-like domain of MMPs is highly conserved and shows sequence similarity to the plasma protein, hemopexin. The ... Most members of the MMP family are organized into three basic, distinctive, and well-conserved domains based on structural ... the three histidine residues that coordinate with the catalytic zinc are conserved among all the MMPs. Little is known about ...
An unusual coding sequence from a Drosophila clock gene is conserved in vertebrates. Nature. 1985, 317 (6036): 445-8. PMID ...
... they found Histone IV sequence to be highly conserved between peas and calf thymus.[22] However, their work on the biochemical ... 3. Complete amino acid sequence of pea seedling histone IV; comparison with the homologous calf thymus histone". The Journal of ... The 4 'core' histones (H2A, H2B, H3 and H4) are relatively similar in structure and are highly conserved through evolution, all ... In the early 1960s, before the types of histones were known and before histones were known to be highly conserved across ...
Although CYP51's mode of action has been well conserved, the protein's sequence varies considerably between biological kingdoms ... sequence alignment analysis reveals that there are six regions in the protein that are highly conserved in eukaryotes.[7] These ... the active site contains a heme prosthetic group in which the iron is tethered to a thiolate ligand on a conserved cysteine ... The cytochrome P450 isoenzymes are a conserved group of proteins that serve as key players in the metabolism of organic ...
... and were separated by a non-conserved region of variable length. This indicated the importance of these two sequence motifs ( ... The SM1 sequence motif corresponds to the β1, β2, β3 strands, and the SM2 sequence motif corresponds to the β4 and β5 strands. ... Sequence alignment between the various LSm homologs are the appropriate tool for this, such as multiple sequence alignment of ... "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". ...
... of amino acid sequence conserved) and STIM2 (31% identical; 46% of amino acid sequence conserved). Unicellular eukaryotes such ... Their N-terminal regions share 66% similarity over 577 aas (85% of the amino acid sequence of STIM1). Only the extreme of the C ... It shows a significant sequence divergence between both isoforms and in STIM1, the C-terminal region is essential for the ... Ercan E, Momburg F, Engel U, Temmerman K, Nickel W, Seedorf M (December 2009). "A conserved, lipid-mediated sorting mechanism ...
LepA has a highly conserved sequence. LepA orthologs have been found in bacteria and almost all eukaryotes. The conservation in ... The amino acid sequence of LepA indicates that it is a G protein, which consists of five known domains. The first four domains ... However, Domain IV of EF-G has been shown through several studies to occupy the decoding sequence of the A site after the tRNAs ... March PE, Inouye M (November 1985). "GTP-binding membrane protein of Escherichia coli with sequence homology to initiation ...
The Conserved Domain database (CDD) of protein contains sequence profiles that characterize highly conserved domains within ... BLAST is an algorithm used for calculating sequence similarity between biological sequences such as nucleotide sequences of DNA ... and amino acid sequences of proteins.[6] BLAST is a powerful tool for finding sequences similar to the query sequence within ... NCBI distributed the first version of Entrez in 1991, composed of nucleotide sequences from PDB and GenBank, protein sequences ...
The conserved sequence motif 'AUACAAnACCC' was boxed. The phylogenetic tree of sRNA-Xcc1 homologs based on multiple alignments ...
These domains are highly conserved monomeric sequences. The second group consists of only the Caenorhabditis elegans protein ... Thorough analysis of the TOG3 domain in zyg-9 provides a basic understanding of this domain that is conserved throughout all ... The XMAP215/Dis1 family is a highly conserved group of microtubule-associated proteins (MAPs) in eukaryotic organisms. These ... Cullen, C. Fiona; Peter Deák; David Glover; Hiroyuki Ohkura (September 1999). "A Gene Encoding a Conserved Microtubule- ...
The sequence on the carboxy terminal side of the conserved region is a well-known site for cleavage in neuropeptides.[7] ... Sequences found in transmembrane spanning regions one, four, and seven are all very highly conserved throughout species. ... Each of these fragments has a similar conserved region at the C-terminal sequence consisting of ten amino acids.[7] ... Also within this conserved family is a C-terminus that has an amide added to it. This family which kisspeptin includes ...
"Sequence of cDNAs for mammalian H2A.Z, an evolutionarily diverged but highly conserved basal histone H2A isoprotein species" ... RNA polymerase II core promoter proximal region sequence-specific DNA binding. • RNA polymerase II distal enhancer sequence- ... RNA polymerase II core promoter sequence-specific DNA binding. • protein heterodimerization activity. ... "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A ...
... a Robust Tool for Conserved Sequence Identification". Bioinformatics. 21 (24): 4420-4422. doi:10.1093/bioinformatics/bti719. ... Numerous short DNA capture sequences were designed , and used to both type and subtype influenza A viruses by taking advantage ... Dawson, Erica D.; Rowlen, Kathy L. (February 2010). FluChip: Robust Sequence Selection Method for a Diagnostic Influenza ... "Robust Sequence Selection Method Used To Develop the FluChip Diagnostic Microarray for Influenza Virus". Journal of Clinical ...
"Identification and characterization of multi-species conserved sequences". Genome Research. 13 (12): 2507-18. doi:10.1101/gr. ... His research focuses on developing new algorithms for the detection of functional regions in DNA sequences. Blanchette studied ... His research focuses on developing computational methods for detecting functional regions in DNA sequences. His postdoctoral ... 2003). "Comparative analyses of multi-species sequences from targeted genomic regions". Nature. 424 (6950): 788-93. doi:10.1038 ...
RNA polymerase II regulatory region sequence-specific DNA binding. • DNA binding. • sequence-specific DNA binding. • ... The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in ... transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. • RNA ... "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A ...
conserved noncoding sequence. TFBS. transcription factor binding site. CMM. Comparative Motif Mapping. FDR. false discovery ... Inference of Transcriptional Networks in Arabidopsis through Conserved Noncoding Sequence Analysis. Jan Van de Velde, Ken S. ... Inference of Transcriptional Networks in Arabidopsis through Conserved Noncoding Sequence Analysis. Jan Van de Velde, Ken S. ... Inference of Transcriptional Networks in Arabidopsis through Conserved Noncoding Sequence Analysis. Jan Van de Velde, Ken S. ...
The bromodomain: a conserved sequence found in human, Drosophila and yeast proteins.. Haynes SR1, Dollard C, Winston F, Beck S ...
This sequence predicts that sifB encodes a 10-aa protein. To determine the sequence of sifB, DNA sequences containing sifB were ... A conserved amino acid sequence directing intracellular type III secretion by Salmonella typhimurium. Edward A. Miao and Samuel ... SspH1 and SlrP both contain a conserved sequence, MFNIXNXQ, at the amino terminus, whereas the remainder of the family contains ... PCR and DNA sequence analyses were performed as described (16). sseI was sequenced from pEM55 (which was cloned from a size- ...
I. Conserved genetic and nucleic acid base sequence homologies. D Dubnau, I Smith, P Morell, and J Marmur ...
Identifying conserved sequences can be used to discover and predict functional sequences such as genes. Conserved sequences ... Sequences may also recombine or be deleted due to chromosomal rearrangements. Conserved sequences are sequences which persist ... Highly conserved DNA sequences are thought to have functional value, although the role for many highly conserved non-coding DNA ... In evolutionary biology, conserved sequences are similar or identical sequences in nucleic acids (DNA and RNA) or proteins ...
Rapid identification of flaviviruses based on conserved NS5 gene sequences.. Fulop L1, Barrett AD, Phillpotts R, Martin K, ... Two conserved regions in the sequence of the NS5 gene of Flaviviruses were identified. Primers were designed from the consensus ... The authenticity of the amplified fragment was confirmed by nucleotide sequencing. A band of the expected size was also ... sequence of these regions and were used in a reverse transcription/polymerase chain reaction (RT/PCR) to amplify a region of ...
A conserved DNA sequence in homoeotic genes of the Drosophila Antennapedia and bithorax complexes.. McGinnis W, Levine MS, ... A repetitive DNA sequence has been identified in the Drosophila melanogaster genome that appears to be localized specifically ... Initially identified in cloned copies of the genes Antennapedia, Ultrabithorax and fushi tarazu, the sequence is also contained ...
Untranslated regulatory sequences need to be conserved, for example. But regulatory sequences have more error tolerance than ... Conserved Non-Genic Sequences WhatsNEW. There are about 60,000 CNGs in the human genome, about twice the number of coding ... "conserved non-genic sequences" (CNGs) of unknown function that are better conserved than genes, and twice as abundant. It was ... Len A. Pennacchio et al., "In vivo enhancer analysis of human conserved non-coding sequences" [text], 10.1038/nature05295, p ...
A conserved non-coding sequence (CNS) is a DNA sequence of noncoding DNA that is evolutionarily conserved. These sequences are ... Conserved non-coding sequences can be important sites of evolutionary divergence as mutations in these regions may alter the ... Jan 2005). "Plant conserved non-coding sequences and paralogue evolution". Trends in Genetics. 21 (1): 60-65. doi:10.1016/j.tig ... Intron sequences may be conserved, often because they contain expression regulating elements that put functional constraints on ...
Genomes and Genes about Experts and Doctors on conserved sequence in Kagoshima, Japan ... Experts and Doctors on conserved sequence in Kagoshima, Japan. Summary. Locale: Kagoshima, Japan ... You are here: Locale , Japan , Experts and Doctors on conserved sequence in Kagoshima, Japan ... These results and phylogenetic analysis suggested that the medaka neu3a is an evolutionally conserved sialidase with regard to ...
Amino Acid Sequence, Cells, Computational Biology, Conserved Sequence, Databases, Protein, Protein Sorting Signals, Protein ... We found that a simple measure for sequence similarity accounting for pairwise sequence identity and alignment length, the HSSP ... The subcellular compartment is generally more conserved than what might have been expected given that short sequence motifs ... The more proteins diverged in sequence, the more difficult it becomes for bioinformatics to infer similarities of protein ...
Functional importance of a conserved sequence motif in FhaC, a prototypic member of the TpsB/Omp85 superfamily.. Delattre AS1, ... This motif is conserved in a predicted loop between two β-barrel strands in more distant relatives of FhaC involved in protein ... The VRGY tetrad is highly conserved in the TpsB family and, in FhaC, it is located at the tip of L6 reaching the periplasm. ... Replacement of the conserved Tyr affects the channel properties, but not the secretion activity, suggesting that this residue ...
A conserved AU sequence from the 3 untranslated region of GM-CSF mRNA mediates selective mRNA degradation.. Shaw G, Kamen R. ... We introduced a 51 nucleotide AT sequence from a human lymphokine gene, GM-CSF, into the 3 untranslated region of the rabbit ... The instability conferred by the AU sequence in the mRNA was partially alleviated by treatment of the cells with cycloheximide ... We propose that the AU sequences are the recognition signal for an mRNA processing pathway which specifically degrades the ...
Conserved DNA sequences adjacent to chromosome fragmentation and telomere addition sites in Euplotes crassus.. Klobutcher LA1, ... we have defined a 10 bp conserved sequence element (E-Cbs, 5-HATTGAAaHH-3, H = A, C or T) near chromosome fragmentation sites ... In this study, the sequences of 58 macronuclear DNA termini and eight regions of the micronuclear genome containing chromosome ... The identification of adjacent macronuclear-destined sequences that overlap by 6 bp provides support for the model. Finally, ...
DNA Ultra-Conserved Sequences Found Between Humans, Mice Rats Comparisons between the DNA sequences of humans, mice, rats, and ... The first indication of the existence of ultra-conserved sequence regions was found in the initial comparison of the human and ... Researchers have found precisely the same sequences in the genomes of humans, rats, and mice; sequences that are 95 to 99 ... Comparison between the genomes of humans, mice, and rats showed many identical sequences. Most of those sequences do not code ...
Evolutionary Discrimination of Mammalian Conserved Non-Genic Sequences (CNGs) Message Subject. (Your Name) has forwarded a page ... Evolutionary Discrimination of Mammalian Conserved Non-Genic Sequences (CNGs). By Emmanouil T. Dermitzakis, Alexandre Reymond, ... Evolutionary Discrimination of Mammalian Conserved Non-Genic Sequences (CNGs). By Emmanouil T. Dermitzakis, Alexandre Reymond, ... Analysis of the human and mouse genomes identified an abundance of conserved non-genic sequences (CNGs). The significance and ...
... Saikat Chakrabarti, Christopher J. Lanczycki, Anna R. ... A block model represents conserved sequence/structure regions which are highly unlikely to contain gaps and are common to all ... Realignment of each sequence can correct misalignments between a given sequence and the rest of the profile and at the same ... Realignment of each sequence can correct misalignments between a given sequence and the rest of the profile by shifting the ...
A slippery sequence, U UUU UUA, and a stem-loop are well-defined RNA features modulating −1 frameshifting in HIV-1. The GGG ... This GGG codon is highly conserved in natural isolates of HIV. When the natural intercodon was replaced with a stop codon two ... glycine codon immediately following the slippery sequence (the intercodon) contributes structurally to the start of the stem- ...
Sets of EcoRI fragments containing ribosomal RNA sequences are conserved among different strains of Listeria monocytogenes. J L ... Sets of EcoRI fragments containing ribosomal RNA sequences are conserved among different strains of Listeria monocytogenes - ... Sets of EcoRI fragments containing ribosomal RNA sequences are conserved among different strains of Listeria monocytogenes ... Sets of EcoRI fragments containing ribosomal RNA sequences are conserved among different strains of Listeria monocytogenes ...
... E V Koonin and M P Deutscher ... Sequence analysis of the Escherichia coli dnaE gene. J Bacteriol. 1987 Dec;169(12):5735-5744. [PMC free article] [PubMed] ... Sequence and transcriptional analysis of the Escherichia coli rnt gene encoding RNase T. J Biol Chem. 1992 Dec 15;267(35):25609 ...
Three-dimensional structure of Schistosoma japonicum glutathione S-transferase fused with a six-amino acid conserved ... THE THREE-DIMENSIONAL STRUCTURE OF GLUTATHIONE S-TRANSFERASE OF SCHISTOSOMA JAPONICUM FUSED WITH A CONSERVED NEUTRALIZING ... Structures of protein chains with identical sequences (sequence identity > 95%) are aligned, superimposed and clustered. ... Sequence Similarity Clusters for the Entities in PDB 1GNE Legend Entity #1 , Chains: A GLUTATHIONE S-TRANSFERASE protein, ...
In conclusion, the binding of PSI and dsx pre-mRNA are generally conserved in both B. mori and S. litura. These findings ... "P-element Somatic Inhibitor Protein Binding a Target Sequence in dsx Pre-mRNA Conserved in Bombyx mori and Spodoptera litura." ... P-element Somatic Inhibitor Protein Binding a Target Sequence in dsx Pre-mRNA Conserved in Bombyx mori and Spodoptera litura ... P-element Somatic Inhibitor Protein Binding a Target Sequence in dsx Pre-mRNA Conserved in Bombyx mori and Spodoptera litura. ...
STRUCTURE AND FUNCTION OF THE CATALYTIC SITE MUTANT ASP99ASN OF PHOSPHOLIPASE A2: ABSENCE OF CONSERVED STRUCTURAL WATER. ... Structures of protein chains with identical sequences (sequence identity > 95%) are aligned, superimposed and clustered. ... Sequence Similarity Clusters for the Entities in PDB 1CEH Legend Entity #1 , Chains: A PHOSPHOLIPASE A2 protein, length: 123 ( ... Blast this sequence against all of PDB Archive.. Rank. In each cluster, the chains are sorted (i.e. ranked) according to the ...
Novel aromatic inhibitors of influenza virus neuraminidase make selective interactions with conserved residues and water ... NOVEL AROMATIC INHIBITORS OF INFLUENZA VIRUS NEURAMINIDASE MAKE SELECTIVE INTERACTIONS WITH CONSERVED RESIDUES AND WATER ... Sequence database residues 83-467 11320 3.2.1.18 , Details 6 3SAL 1 A, B Neuraminidase UNP residues 79-473 11320 3.2.1.18 , ... Structures of protein chains with identical sequences (sequence identity > 95%) are aligned, superimposed and clustered. ...
Sequence Similarity Clusters for the Entities in PDB 1I36 Legend Entity #1 , Chains: A,B CONSERVED HYPOTHETICAL PROTEIN MTH1747 ... Structures of protein chains with identical sequences (sequence identity > 95%) are aligned, superimposed and clustered. ... Blast this sequence against all of PDB Archive.. Rank. In each cluster, the chains are sorted (i.e. ranked) according to the ... Sequence Similarity Cutoff. Rank. Chains in Cluster. Cluster ID / Name. Structural variation in cluster. ...
  • The results suggest that, regardless of domestication selection pressure to develop breeds having extreme differences in skeletal size, the FGFR3 gene is conserved. (biomedcentral.com)
  • Although its function is unknown, the observation that this gene is conserved in the mouse implies it has some function. (wikipedia.org)
  • The aim of this study was to identify conserved and novel miRNAs in grass carp in response to GCRV infection, as well as attempt to reveal the mechanism underlying GCRV pathogenesis and hemorrhagic symptoms. (biomedcentral.com)
  • To classify Listeria monocytogenes using taxonomic characters derived from the rRNA operons and their flanking sequences, we studied a sample of 1346 strains within the taxon. (pnas.org)
  • At the same time, it has often been noted that the 16s rRNA gene is too conserved to separate between prokaryotes at finer taxonomic levels. (biomedcentral.com)
  • Using a method developed by Hunt, Shine and Dalgarno showed that the nucleotide tract at the 3' end of E. coli 16S ribosomal RNA (rRNA) is pyrimidine-rich and has the sequence -PyACCUCCUUA 3' OH. (wikipedia.org)
  • We have isolated and analyzed human CTCF cDNA clones and show here that the ubiquitously expressed 11-zinc-finger factor CTCF is an exceptionally highly conserved protein displaying 93% identity between avian and human amino acid sequences. (asm.org)
  • cDNA sequence, tissue-specific expression, and chromosomal mapping of the human slow-twitch skeletal muscle isoform of troponin I". Genomics. (wikipedia.org)
  • Analysis of 2,086 conserved sequence blocks (CSBs), identified from 135 characterized enhancers, reveals most CSBs consist of shorter overlapping/adjacent elements that are either enhancer type-specific or common to enhancers with divergent regulatory behaviors. (biomedcentral.com)
  • Close inspection of enhancer MCSs reveals that these sequences are made up of smaller blocks of conserved sequences, designated here as 'conserved sequence blocks' (CSBs). (biomedcentral.com)