Consensus: General agreement or collective opinion; the judgment arrived at by most of those concerned.Consensus Sequence: A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.Consensus Development Conferences as Topic: Presentations of summary statements representing the majority agreement of physicians, scientists, and other professionals convening for the purpose of reaching a consensus--often with findings and recommendations--on a subject of interest. The Conference, consisting of participants representing the scientific and lay viewpoints, is a significant means of evaluating current medical thought and reflects the latest advances in research for the respective field being addressed.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Delphi Technique: An iterative questionnaire designed to measure consensus among individual responses. In the classic Delphi approach, there is no interaction between responder and interviewer.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Consensus Development Conferences, NIH as Topic: Articles on conferences sponsored by NIH presenting summary statements representing the majority agreement of physicians, scientists, and other professionals convening for the purpose of reaching a consensus on a subject of interest. This heading is used for NIH consensus conferences as a means of scientific communication. In indexing it is viewed as a type of review article and as a tag for any article appearing in any publication of the NIH Office of Medical Applications of Research (OMAR).Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Sequence Homology, Nucleic Acid: The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Societies, Medical: Societies whose membership is limited to physicians.Practice Guidelines as Topic: Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Mutagenesis, Site-Directed: Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.Regulatory Sequences, Nucleic Acid: Nucleic acid sequences involved in regulating the expression of genes.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Restriction Mapping: Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Amino Acid Motifs: Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Introns: Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes.Dothiepin: A tricyclic antidepressant with some tranquilizing action.Evidence-Based Medicine: An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)Haemophilus somnus: A species of gram-negative bacteria (currently incertae sedis) causing multisystem disease in CATTLE.Conserved Sequence: A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.Bacterial Proteins: Proteins found in any species of bacterium.Expert Testimony: Presentation of pertinent data by one with special skill or knowledge representing mastery of a particular subject.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Recombinant Fusion Proteins: Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.DNA Cleavage: A reaction that severs one of the covalent sugar-phosphate linkages between NUCLEOTIDES that compose the sugar phosphate backbone of DNA. It is catalyzed enzymatically, chemically or by radiation. Cleavage may be exonucleolytic - removing the end nucleotide, or endonucleolytic - splitting the strand in two.DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Repressor Proteins: Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.Genes, Bacterial: The functional hereditary units of BACTERIA.Guidelines as Topic: A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Antigens, CD1d: A major histocompatibily complex class I-like protein that plays a unique role in the presentation of lipid ANTIGENS to NATURAL KILLER T-CELLS.Exons: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Nucleic Acid Conformation: The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.Transcriptional Activation: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.Electrophoretic Mobility Shift Assay: An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.Phosphorylation: The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.Oligodeoxyribonucleotides: A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.Enhancer Elements, Genetic: Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.Response Elements: Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.Gene Expression Regulation, Bacterial: Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Sequence Deletion: Deletion of sequences of nucleic acids from the genetic material of an individual.Genes, Reporter: Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.Software: Sequential operating programs and data which instruct the functioning of a digital computer.RNA Splicing: The ultimate exclusion of nonsense sequences or intervening sequences (introns) before the final RNA transcript is sent to the cytoplasm.Sp1 Transcription Factor: Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Trans-Activators: Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.Interferon Regulatory Factors: A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression. IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence.DNA Footprinting: A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.International Cooperation: The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.EuropeSaccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.Gene Library: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.Oligonucleotide Probes: Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.Mutagenesis: Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.Open Reading Frames: A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Observer Variation: The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).Operon: In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.Chloramphenicol O-Acetyltransferase: An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.Zinc Fingers: Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.DNA, Viral: Deoxyribonucleic acid that makes up the genetic material of viruses.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.United StatesRNA: A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Multigene Family: A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)Genes, Regulator: Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.Deoxyribonuclease I: An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.Sequence Analysis: A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information.Kinetics: The rate dynamics in chemical or physical systems.DNA, Fungal: Deoxyribonucleic acid that makes up the genetic material of fungi.Internationality: The quality or state of relating to or affecting two or more nations. (After Merriam-Webster Collegiate Dictionary, 10th ed)Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Oligonucleotides: Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)Point Mutation: A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Models, Genetic: Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Health Planning Guidelines: Recommendations for directing health planning functions and policies. These may be mandated by PL93-641 and issued by the Department of Health and Human Services for use by state and local planning agencies.Blotting, Northern: Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.CycloheptanesPeptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Alternative Splicing: A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.TATA Box: A conserved A-T rich sequence which is contained in promoters for RNA polymerase II. The segment is seven base pairs long and the nucleotides most commonly found are TATAAAA.Peptide Library: A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Canada: The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.Glycosylation: The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.Genetic Variation: Genotypic differences observed among individuals in a population.Serine: A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.Clinical Trials as Topic: Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.Medical Illustration: The field which deals with illustrative clarification of biomedical concepts, as in the use of diagrams and drawings. The illustration may be produced by hand, photography, computer, or other electronic or mechanical methods.Furin: A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.Blotting, Southern: A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.Membrane Proteins: Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.Protein Processing, Post-Translational: Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.Research Design: A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.Gene Expression Regulation, Enzymologic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.Genes, Fungal: The functional hereditary units of FUNGI.Fungal Proteins: Proteins found in any species of fungus.Genomic Library: A form of GENE LIBRARY containing the complete DNA sequences present in the genome of a given organism. It contrasts with a cDNA library which contains only sequences utilized in protein coding (lacking introns).Viral Proteins: Proteins found in any species of virus.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.Nucleotide Mapping: Two-dimensional separation and analysis of nucleotides.Luciferases: Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.Cluster Analysis: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.Repetitive Sequences, Amino Acid: A sequential pattern of amino acids occurring more than once in the same protein sequence.Radiation Oncology: A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.Amino Acid Substitution: The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.Nutritional Support: The administration of nutrients for assimilation and utilization by a patient by means other than normal eating. It does not include FLUID THERAPY which normalizes body fluids to restore WATER-ELECTROLYTE BALANCE.DNA Transposable Elements: Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Saccharomyces cerevisiae Proteins: Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.Transcription Initiation Site: The first nucleotide of a transcribed DNA sequence where RNA polymerase (DNA-DIRECTED RNA POLYMERASE) begins synthesizing the RNA transcript.RNA Splice Sites: Nucleotide sequences located at the ends of EXONS and recognized in pre-messenger RNA by SPLICEOSOMES. They are joined during the RNA SPLICING reaction, forming the junctions between exons.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Protein Biosynthesis: The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.RNA-Binding Proteins: Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.Binding, Competitive: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.DNA Probes: Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Chromatin Immunoprecipitation: A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.Reference Standards: A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.Escherichia coli Proteins: Proteins obtained from ESCHERICHIA COLI.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.RNA Precursors: RNA transcripts of the DNA that are in some unfinished stage of post-transcriptional processing (RNA PROCESSING, POST-TRANSCRIPTIONAL) required for function. RNA precursors may undergo several steps of RNA SPLICING during which the phosphodiester bonds at exon-intron boundaries are cleaved and the introns are excised. Consequently a new bond is formed between the ends of the exons. Resulting mature RNAs can then be used; for example, mature mRNA (RNA, MESSENGER) is used as a template for protein production.Decision Making: The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.Disease Management: A broad approach to appropriate coordination of the entire disease treatment process that often involves shifting away from more expensive inpatient and acute care to areas such as preventive medicine, patient counseling and education, and outpatient care. This concept includes implications of appropriate versus inappropriate therapy on the overall cost and clinical outcome of a particular disease. (From Hosp Pharm 1995 Jul;30(7):596)5' Untranslated Regions: The sequence at the 5' end of the messenger RNA that does not code for product. This sequence contains the ribosome binding site and other transcription and translation regulating sequences.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Expressed Sequence Tags: Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.DNA Restriction Enzymes: Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.Physician's Practice Patterns: Patterns of practice related to diagnosis and treatment as especially influenced by cost of the service requested and provided.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Nucleic Acid Hybridization: Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)COS Cells: CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Genome, Viral: The complete genetic complement contained in a DNA or RNA molecule in a virus.Dental Scaling: Removal of dental plaque and dental calculus from the surface of a tooth, from the surface of a tooth apical to the gingival margin accumulated in periodontal pockets, or from the surface coronal to the gingival margin.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.PhosphoproteinsBase Composition: The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.Regulon: In eukaryotes, a genetic unit consisting of a noncontiguous group of genes under the control of a single regulator gene. In bacteria, regulons are global regulatory systems involved in the interplay of pleiotropic regulatory domains and consist of several OPERONS.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Guideline Adherence: Conformity in fulfilling or following official, recognized, or institutional requirements, guidelines, recommendations, protocols, pathways, or other standards.Databases, Factual: Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Dentition, Mixed: The complement of teeth in the jaws after the eruption of some of the permanent teeth but before all the deciduous teeth are absent. (Boucher's Clinical Dental Terminology, 4th ed)Great Britain3T3 Cells: Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.Quality Assurance, Health Care: Activities and programs intended to assure or improve the quality of care in either a defined medical setting or a program. The concept includes the assessment or evaluation of the quality of care; identification of problems or shortcomings in the delivery of care; designing activities to overcome these deficiencies; and follow-up monitoring to ensure effectiveness of corrective steps.DNA-Directed RNA Polymerases: Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).Organ Specificity: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Transcription Factor AP-2: A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.Review Literature as Topic: Published materials which provide an examination of recent or current literature. Review articles can cover a wide range of subject matter at various levels of completeness and comprehensiveness based on analyses of literature that may include research findings. The review may reflect the state of the art. It also includes reviews as a literary form.Sigma Factor: A protein which is a subunit of RNA polymerase. It effects initiation of specific RNA chains from DNA.

Ethical considerations in international HIV vaccine trials: summary of a consultative process conducted by the Joint United Nations Programme on HIV/AIDS (UNAIDS). (1/739)

Research that is initiated, designed or funded by sponsor agencies based in countries with relatively high social and economic development, and conducted in countries that are relatively less developed, gives rise to many important ethical challenges. Although clinical trials of HIV vaccines began ten years ago in the US and Europe, an increasing number of trials are now being conducted or planned in other countries, including several that are considered "developing" countries. Safeguarding the rights and welfare of individuals participating as research subjects in developing countries is a priority. In September, 1997, the Joint United Nations Programme on HIV/AIDS (UNAIDS) embarked on a process of international consultation; its purpose was further to define the important ethical issues and to formulate guidance that might facilitate the ethical design and conduct of HIV vaccine trials in international contexts. This paper summarises the major outcomes of the UNAIDS consultative process.  (+info)

Clinical ethics committees and the formulation of health care policy. (2/739)

For some time, clinical ethics committees (CECs) have been a prominent feature of hospitals in North America. Such committees are less common in the United Kingdom and Europe. Focusing on the UK, this paper evaluates why CECs have taken so long to evolve and assesses the roles that they should play in health care policy and clinical decision making. Substantive and procedural moral issues in medicine are differentiated, the former concerning ethicolegal principles and their paradigmatic application to clinical practice and the latter dealing with how such application should be negotiated in the face of disagreement and/or uncertainty. It will be argued that the role of CECs is both substantive and procedural. Provided that they do not overstep their appropriate moral and professional boundaries, CECs will be shown to have an important and positive function in improving hospital care within the UK and elsewhere.  (+info)

Quality and methods of developing practice guidelines. (3/739)

BACKGROUND: It is not known whether there are differences in the quality and recommendations between evidence-based (EB) and consensus-based (CB) guidelines. We used breast cancer guidelines as a case study to assess for these differences. METHODS: Five different instruments to evaluate the quality of guidelines were identified by a literature search. We also searched MEDLINE and the Internet to locate 8 breast cancer guidelines. These guidelines were classified in three categories: evidence based, consensus based and consensus based with no explicit consideration of evidence (CB-EB). Each guideline was evaluated by three of the authors using each of the instruments. For each guideline we assessed the agreement among 14 decision points which were selected from the NCCN (National Cancer Comprehensive Network) guidelines algorithm. For each decision point we recorded the level of the quality of the information used to support it. A regression analysis was performed to assess if the percentage of high quality evidence used in the guidelines development was related to the overall quality of the guidelines. RESULTS: Three guidelines were classified as EB, three as CB-EB and two as CB. The EB guidelines scored better than CB, with the CB-EB scoring in the middle among all instruments for guidelines quality assessment. No major disagreement in recommendations was detected among the guidelines regardless of the method used for development, but the EB guidelines had a better agreement with the benchmark guideline for any decision point. When the source of evidence used to support decision were of high quality, we found a higher level of full agreement among the guidelines' recommendations. Up to 94% of variation in the quality score among guidelines could be explained by the quality of evidence used for guidelines development. CONCLUSION: EB guidelines have a better quality than CB guidelines and CB-EB guidelines. Explicit use of high quality evidence can lead to a better agreement among recommendations. However, no major disagreement among guidelines was noted regardless of the method for their development.  (+info)

Inter-rater agreement in the scoring of abstracts submitted to a primary care research conference. (4/739)

BACKGROUND: Checklists for peer review aim to guide referees when assessing the quality of papers, but little evidence exists on the extent to which referees agree when evaluating the same paper. The aim of this study was to investigate agreement on dimensions of a checklist between two referees when evaluating abstracts submitted for a primary care conference. METHODS: Anonymised abstracts were scored using a structured assessment comprising seven categories. Between one (poor) and four (excellent) marks were awarded for each category, giving a maximum possible score of 28 marks. Every abstract was assessed independently by two referees and agreement measured using intraclass correlation coefficients. Mean total scores of abstracts accepted and rejected for the meeting were compared using an unpaired t test. RESULTS: Of 52 abstracts, agreement between reviewers was greater for three components relating to study design (adjusted intraclass correlation coefficients 0.40 to 0.45) compared to four components relating to more subjective elements such as the importance of the study and likelihood of provoking discussion (0.01 to 0.25). Mean score for accepted abstracts was significantly greater than those that were rejected (17.4 versus 14.6, 95% CI for difference 1.3 to 4.1, p = 0.0003). CONCLUSIONS: The findings suggest that inclusion of subjective components in a review checklist may result in greater disagreement between reviewers. However in terms of overall quality scores, abstracts accepted for the meeting were rated significantly higher than those that were rejected.  (+info)

Priority setting for new technologies in medicine: a transdisciplinary study. (5/739)

BACKGROUND: Decision makers in health care organizations struggle with how to set priorities for new technologies in medicine. Traditional approaches to priority setting for new technologies in medicine are insufficient and there is no widely accepted model that can guide decision makers. DISCUSSION: Daniels and Sabin have developed an ethically based account about how priority setting decisions should be made. We have developed an empirically based account of how priority setting decisions are made. In this paper, we integrate these two accounts into a transdisciplinary model of priority setting for new technologies in medicine that is both ethically and empirically based. SUMMARY: We have developed a transdisciplinary model of priority setting that provides guidance to decision makers that they can operationalize to help address priority setting problems in their institution.  (+info)

Consensus guidelines on analgesia and sedation in dying intensive care unit patients. (6/739)

BACKGROUND: Intensivists must provide enough analgesia and sedation to ensure dying patients receive good palliative care. However, if it is perceived that too much is given, they risk prosecution for committing euthanasia. The goal of this study is to develop consensus guidelines on analgesia and sedation in dying intensive care unit patients that help distinguish palliative care from euthanasia. METHODS: Using the Delphi technique, panelists rated levels of agreement with statements describing how analgesics and sedatives should be given to dying ICU patients and how palliative care should be distinguished from euthanasia. Participants were drawn from 3 panels: 1) Canadian Academic Adult Intensive Care Fellowship program directors and Intensive Care division chiefs (N = 9); 2) Deputy chief provincial coroners (N = 5); 3) Validation panel of Intensivists attending the Canadian Critical Care Trials Group meeting (N = 12). RESULTS: After three Delphi rounds, consensus was achieved on 16 statements encompassing the role of palliative care in the intensive care unit, the management of pain and suffering, current areas of controversy, and ways of improving palliative care in the ICU. CONCLUSION: Consensus guidelines were developed to guide the administration of analgesics and sedatives to dying ICU patients and to help distinguish palliative care from euthanasia.  (+info)

Development of the Knee Standardized Clinical Interview: a research tool for studying the primary care clinical epidemiology of knee problems in older adults. (7/739)

OBJECTIVE: To develop a standardized clinical interview, incorporating the perspectives of general practitioners (GPs) and rheumatologists, for primary care clinical epidemiological studies of adults aged 50 yr and over with knee problems. METHODS: Two parallel, consensus development studies using a modified nominal group technique involving GPs (n=5) and consultant rheumatologists (n=4) from North Staffordshire with reference panels of GPs (n=28) and rheumatologists (n=11) from selected centres in Great Britain, respectively. A single standardized clinical interview was formed using the clinical history questions identified in the consensus development studies and its feasibility was tested in a small sample of patients. RESULTS: In the GP consensus development study, 115 clinical history questions were identified, of which 71 were of agreed importance following postal rating, face-to-face discussion and re-rating. In the rheumatologist study, 158 questions were identified, of which 47 were of agreed importance. There was considerable overlap in the clinical history questions independently developed by the two studies. A single standardized clinical interview containing 74 questions was formed. It contained questions on the history, onset and recent course of the complaint; nature, location and severity of current knee symptoms; impact of knee problem; past history of knee problems; family history; comorbidity; previous/current investigations and treatment; ideas, concerns and expectations. In preliminary testing it took 20-45 min to conduct and was comprehensible to patients. CONCLUSIONS: A research tool-the Knee Standardized Clinical Interview (KNE-SCI)-has been formed from consensus development studies involving GPs and rheumatologists. In preliminary testing, it is comprehensible to patients, and forms a coherent clinical interview for research data collection. However, further evaluation is required to determine its accuracy and reliability and its usefulness for clinical epidemiological research.  (+info)

Building consensus on nomenclature and disease classification for ankylosing spondylitis: results and discussion of a questionnaire prepared for the International Workshop on New Treatment Strategies in Ankylosing Spondylitis, Berlin, Germany, 18-19 January 2002. (8/739)

BACKGROUND: There is currently no universal consensus on nomenclature for spondyloarthropathy (SpA), or on activity and severity criteria for ankylosing spondylitis (AS). METHOD: Points of agreement and majority opinions among 28 international experts in the field were identified by questionnaire. Agreement was defined as >80% concurrence, clear majority as >60% concurrence, and a majority or trend as >50% concurrence. RESULTS: Respondents agreed on the need for one term that reflects the inflammatory nature of the disease, but no agreement was reached on a specific term. Agreement included subdivision of patients with SpA into AS, psoriatic arthritis, inflammatory bowel disease associated arthritis, and undifferentiated spondyloarthritis/spondyloarthropathy. A majority of experts defined active disease as fulfilling classification criteria for AS and/or a SpA, and disease activity measured by a Bath AS Disease Activity Index (BASDAI) score >4 determined by two patient visits during a two month period, but no maximum radiographic score. The majority of participants considered failure of treatment response to non-steroidal anti-inflammatory drugs (NSAIDs) alone to be a prerequisite for active/severe AS, and 15/28 (54%) thought that NSAID treatment failure should be defined as lack of response to two or more NSAIDs. CONCLUSIONS: Respondents agreed that a two to five year study is the ethical method to demonstrate effects of anti-tumour necrosis factor alpha (TNFalpha) therapy on radiographic progression of AS, and that inclusion criteria should include a certain level of disease activity (measured by BASDAI) and failure of certain treatments. After the efficacy of anti-TNFalpha therapy in AS and psoriatic arthritis is proved, respondents agreed that more studies will be needed to show efficacy for other SpA subsets.  (+info)

*Helvetic Consensus

Calvinism portal The Helvetic Consensus (Latin: Formula consensus ecclesiarum Helveticarum) is a Swiss Reformed symbol drawn up ... The Consensus consists of a preface and twenty-five canons, and states clearly the difference between strict Calvinism and the ... Although the Helvetic Consensus was introduced everywhere in the Reformed Church of Switzerland, it did not long hold its ... 1914). "Helvetic Consensus". New Schaff-Herzog Encyclopedia of Religious Knowledge (third ed.). London and New York: Funk and ...

*Consensus estimate

Such random variable R a p p {\displaystyle R_{app}} is called a consensus estimate: "Consensus" means that, with high ... As a first attempt of a consensus-estimate, let R a p p = ⌊ R m a x ⌋ {\displaystyle R_{app}=\lfloor R_{max}\rfloor } = the ... Consensus estimate is a technique for designing truthful mechanisms in a prior-free mechanism design setting. The technique was ... In the case of digital goods, using this consensus-estimate allows us to attain at least 1/3.39 of the optimal profit, even in ...

*Consensus sequence

Thus a consensus sequence is a model for a putative DNA binding site: it is obtained by aligning all known examples of a ... This is a graphical representation of the consensus sequence, in which the size of a symbol is related to the frequency that a ... Any mutation allowing a mutated nucleotide in the core promoter sequence to look more like the consensus sequence is known as ... A protein binding site, represented by a consensus sequence, may be a short sequence of nucleotides which is found several ...

*Mumbai Consensus

... the discussion will be less about the Washington Consensus or the Beijing Consensus, than about the Mumbai Consensus - a third ... a feature that contradicts both the Washington Consensus in terms of its pace and the Beijing Consensus in terms of its focus. ... The Mumbai Consensus is a term used to refer to India's particular model of economic development, with a "people-centric" ... Instead, a Mumbai Consensus based on the idea of a democratic developmental state, driven not by a mercantilist emphasis on ...

*Consensus reality

... is that which is generally agreed to be reality, based on a consensus view. The appeal to consensus arises ... We can, however, seek to obtain some form of consensus, with others, of what is real. We can use this consensus as a pragmatic ... consensus reality for people who follow a particular theocentric religion is different from consensus reality for those who ... Consensus reality therefore refers to the agreed-upon concepts of reality which people in the world, or a culture or group, ...

*Nassarius consensus

... , common name the striate nassa, is a species of sea snail, a marine gastropod mollusk in the family ... Nassarius consensus (Ravenel, 1861). Retrieved through: World Register of Marine Species on 23 October 2012. Mansfield, W. C. ...

*Consensus Tigurinus

The Consensus Tigurinus or Consensus of Zurich was a document intended to bring unity to the Protestant churches on their ... "The Consensus of Zurich. A.D. 1549". Creeds of Christendom, with a History and Critical notes. I. p. 472. Schaff, pp. 472-3. ... Text of the 1549 Consensus with introductory commentary by Lutherans. ...

*Consensus dynamics

Consensus (computer science) Ren, Wei; Beard, R. W.; Atkins, E. M. (8-10 June 2005). "A survey of consensus problems in multi- ... Consensus dynamics or agreement dynamics is an area of research lying at the intersection of systems theory and graph theory. A ... The agreement protocol or consensus protocol is an unforced dynamical system that is governed by the interconnection topology ... Networks of agents that exchange information to reach consensus include: physiological systems, gene networks, large-scale ...

*Consensus theorem

In Boolean algebra, the consensus theorem or rule of consensus is the identity: x y ∨ x ¯ z ∨ y z = x y ∨ x ¯ z {\displaystyle ... In digital logic, including the consensus term in a circuit can eliminate race hazards. The concept of consensus was introduced ... The consensus is undefined if there is more than one opposition. For the conjunctive dual of the rule, the consensus y ∨ z {\ ... The consensus or consensus term of two conjunctive terms of a disjunction is defined when one term contains the literal a {\ ...

*Overlapping consensus

... is a term coined by John Rawls in A Theory of Justice and developed in Political Liberalism. The term " ... The overlapping consensus could in sum be said to "depend, in effect, on there being a morally significant core of commitments ... Rawls also explains that the overlapping consensus on principles of justice is itself a moral conception and is supported by ... These latter features distinguish his idea of an overlapping consensus from a mere modus vivendi, which is a strategic ...

*Copenhagen Consensus

Published by the Copenhagen Consensus Center. ISBN 978-1-940-00300-9 The Copenhagen Consensus website The Copenhagen Consensus ... One of the Copenhagen Consensus panel experts later distanced himself from the way in which the Consensus results have been ... Copenhagen Consensus 2008 - The world's best investment: Vitamins for undernourished children Copenhagen Consensus 2012 " ... criticised the way this issue was handled in the Consensus project.[citation needed] The 2004 Copenhagen Consensus attracted ...

*Consensus forecast

Consensus-based assessment Consensus decision-making Delphi method Economic forecasting Ensemble averaging Quantile Regression ... In recent decades, consensus forecasts have attracted much interest, backed by the publication of a huge swathe of academic ... One of the advantages of using consensus forecasts is that it can prove useful if there is a high degree of uncertainty or risk ... In sum, the usefulness of the consensus forecast technique has been supported by a wealth of empirical studies in recent ...

*Uniform consensus

In computer science, Uniform consensus is a distributed computing problem that is a similar to the consensus problem with one ... "Uniform consensus is harder than consensus". Journal of Algorithms. 51 (1): 15-37. doi:10.1016/j.jalgor.2003.11.001. ...

*Consensus democracy

On Conflict and Consensus - A Handbook on Formal Consensus Decisionmaking. Consensus voting, the Modified Borda Count (MBC). ... Consensus democracy is the application of consensus decision-making to the process of legislation in a democracy. It is ... Anticipatory democracy Bioregional democracy Confessionalism (politics) Consensus decision-making Consensus voting - the ... Consensus (non-party) government operates in Guernsey in the Channel Islands. Guernsey also operates a non-ministerial system ...

*Consensus conferences

The goal of consensus conferences is for members of the lay audience to deliberate and reach a consensus over a particular ... Missing or empty ,title= (help) The Danish consensus conference model Consensus Conference Manual The Loka Institute - Tracking ... Consensus conferences originated in Denmark in the 1980s and are one of the earliest attempts by policymakers to include the ... The purpose of consensus conferences is "to qualify people's attitudes, inasmuch as they are given all the information they ...

*Scientific consensus

Appeal to authority Consensus reality CUDOS Empiricism Medical consensus Paradigm Status quaestionis "Scientific Consensus". ... Consensus implies general agreement, though not necessarily unanimity. Consensus is normally achieved through communication at ... Scientific consensus is the collective judgment, position, and opinion of the community of scientists in a particular field of ... Scientific consensus may be invoked in popular or political debate on subjects that are controversial within the public sphere ...

*Beutelsbach consensus

Until today Beutelsbach Consensus is of high importance. It is not permissible to catch pupils unprepared or unaware - by ... This is not the case since what is involved here is not a search for a maximum consensus, but the search for a minimal ... The Beutelsbach Consensus constitutes a kind of minimum standard of civic (Politische Bildung) and religious education ( ... consensus. Translated from: Das Konsensproblem in der Politischen Bildung ed. by S. Schiele and H. Schneider, Stuttgart 1977 ( ...

*Taiwan consensus

The DPP hopes to get a "Taiwan Consensus" (a consensus amongst the people) to displace the 1992 consensus, which would be ... This new consensus should then form the basis for negotiations with the PRC. Tsai states further that the Taiwan consensus "is ... The DPP further states, that a "consensus" among the Taiwanese people about the "1992 consensus" does not exist. ... that is the true spirit of the Taiwan consensus". Cross-Strait relations One Country on Each Side 1992 consensus "Tsai details ...

*Washington Consensus

In his article "The Post Washington Consensus Consensus", he claims that the Washington consensus policies failed to ... "The Post Washington Consensus Consensus" (PDF). policydialogue.org. The Initiative for Policy Dialogue. Retrieved April 24, ... The Economics of Empire - Notes on the Washington Consensus, by William Finnegan. Unraveling the Washington Consensus, An ... attacked the Washington Consensus. There never was a real consensus for such policies, he said, and today "a good number of ...

*1992 Consensus

The "1992 Consensus" or "Consensus of 1992" (One China Consensus) is a political term coined by politician Su Chi, referring to ... The 1992 Consensus has been described by Lee Teng-hui, the ROC president between 1988 and 2000, as a consensus without a ... Whether such a Consensus exists is under dispute in Taiwan. The Kuomintang (KMT) proclaims that such consensus exists, while ... Su, Chi: "I created the 1992 Consensus" (Chinese) People's Daily Backgrounder No 1992 consensus, MAC chief says Lu: Taiwan ...

*Consensus clustering

4. Bayesian consensus clustering (BCC) BCC defines a fully Bayesian model for soft consensus clustering in which multiple ... Consensus clustering provides a method that represents the consensus across multiple runs of a clustering algorithm, to ... Consensus clustering has emerged as an important elaboration of the classical clustering problem. Consensus clustering, also ... consensus) clustering which is a better fit in some sense than the existing clusterings. Consensus clustering is thus the ...

*Strasbourg Consensus

The Strasbourg Consensus was a joint statement of doctrine by Reformed and Lutheran theologians, signed in Strasbourg in March ... The signing of the Strasbourg Consensus resolved the open struggles in Stasbourg, with both factions signing a joint statement ... Instead, the handshake would signify two things: that Zanchi accepted the Consensus' formulation of doctrine, and that he ... Simon Sulzer and the Consequences of the 1563 Strasbourg Consensus in Switzerland. Archive for Reformation History 83: 154-179 ...

*Consensus theory

... is concerned with the maintenance or continuation of social order in society. Consensus theory serves as a ... Under consensus theory the absence of conflict is seen as the equilibrium state of society and that there is a general or ... Consensus theory is a social theory that holds a particular political or economic system is a fair system, and that social ... In consensus theory, the rules are seen as integrative, and whoever doesn't respect them is a deviant person. Under conflict ...

*Popular Consensus

... (Spanish: Consenso Popular, CP) was a Bolivian political party founded in 2009. CP founder Óscar Ortiz Antelo ... In the 2009 national election, the party formed an electoral alliance with the National Unity Front, the Consensus Alliance for ...

*Consensus (disambiguation)

Consensus theory of truth, truth as determined by consensus rather than or before other criteria. False-consensus effect, a ... Consensus democracy, democracy where consensus decision-making is used to create, amend or repeal legislation. Consensus-based ... Consensus theorem, an identity in Boolean algebra. Consensus or resolvent term, defined in the consensus theorem. Scientific ... Consensus reality, reality as defined by consensus, particularly popular consensus, rather than or before other (philosophical ...
November 6, 2008 - Lantheus Medical Imaging Inc. welcomes the "Consensus Statement on the Clinical Applications of Ultrasound Contrast" released by the American Society of Echocardiography (ASE) published in the November issue of the Journal of the American Society of Echocardiography.. Developed by members of the U.S. echocardiography community, ASEs consensus statement outlines when and how ultrasound contrast agents are to be used appropriately and efficiently to enhance the diagnostic capability of echocardiography.. "We applaud the American Society of Echocardiography for its leadership in addressing the effective use of contrast ultrasound by authoring the Contrast Consensus Statement guidance document for the echocardiography community. This important consensus statement speaks to the clinical relevance of contrast and guides clinicians towards a team-approach to care for effective contrast use," said Don Kiepert, president and CEO, Lantheus Medical Imaging. "The release of this ...
Lopez-Olivo, M. A., Kallen, M. A., Ortiz, Z., Skidmore, B. and Suarez-Almazor, M. E. (2008), Quality appraisal of clinical practice guidelines and consensus statements on the use of biologic agents in rheumatoid arthritis: A systematic review. Arthritis & Rheumatism, 59: 1625-1638. doi: 10.1002/art.24207 ...
Validation of non-invasive central blood pressure devices: ARTERY Society task force consensus statement on protocol standardization
Despite numerous guidelines on the management of anaemia in surgical patients, there is no pragmatic guidance for the diagnosis and management of anaemia and iron deficiency in the postoperative period. A number of experienced researchers and clinicians took part in a two-day expert workshop and developed the following consensus statement. After presentation of our own research data and local policies and procedures, appropriate relevant literature was reviewed and discussed. We developed a series of best-practice and evidence-based statements to advise on patient care with respect to anaemia and iron deficiency in the postoperative period. These statements include: a diagnostic approach to iron deficiency and anaemia in surgical patients; identification of patients appropriate for treatment; and advice on practical management and follow-up that is easy to implement. Available data allow the fulfilment of the requirements of Pillar 1 of Patient Blood Management. We urge national and ...
The two- and one-half-day conference brought together experts in the field of relevant medical research and health care as well as representatives from the public. After listening to presentations and audience discussion at the conference, the panel, chaired by David J. Kupfer, M.D., Western Psychiatric Institute and Clinic, University of Pittsburgh, Pa., developed the statement.. The consensus statement can be found on the NIH Web site at http://odp.od.nih.gov/consensus/. The document can also be obtained from the NIH Consensus Program Information Center, P.O. Box 2577, Kensington, MD 20891; telephone: 888-644-2667.. ADHD is noted in the report to be the most commonly diagnosed behavioral disorder in childhood and represents a major public health problem. It is estimated that it affects 3 to 5 percent of all school-age children.. The report emphasizes that the impact of ADHD on the individuals with this disorder, their families and society is great. Children with ADHD cannot sit still and pay ...
This is a page with useful consensus documents and standards for people interested in clinical flow cytometry. The standards are listed in alphabetical order . If we are missing something, please feel free to contribute by adding it here. 2006 Bethesda International Consensus Recommendations on Immunophenotypic Analysis of Hematolymphoid Neoplasia by Flow Cytometry. Cytometry Part B, 2007. 2006 Bethesda International Consensus Recommendations on the Immunophenotypic Analysis of Hematolymphoid Neoplasia by Flow Cytometry: Recommendations for Training and Education to Perform Clinical Flow Cytometry, Cytometry Part B 2007 Clinical Flow Cytometric Analysis of Hematolymphoid Cells; Approved Guideline - Second Edition H43-A2 Clinical and Laboratory Standards Institute (CLSI) 2007 Enumeration of Immunologically Defined Cell Populations by Flow Cytometry; Approved Guideline-Second Edition H42-A2 Clinical and Laboratory Standards Institute (CLSI) 2007. MMWR 2003: Guidelines for Performing ...
A study contrasting the CDC Fukuda case definition with the International Consensus Criteria (ICC) for ME finds the ICC selects for a more physicall
A consensus statement is a comprehensive analysis by a panel of experts (i.e., consensus panel) of a scientific or medical issue related to diabetes. A consensus statement is developed immediately after a consensus conference at which presentations are made on the issue under review. The statement represents the panels collective analysis, evaluation, and opinion based, in part, on the conference proceedings. The need for a consensus statement arises when clinicians or scientists desire guidance on a subject for which there is a relative deficiency of comprehensive evidence that might otherwise allow for a more definitive statement to be made.. Consensus statements are published in American Diabetes Association journals and other scientific/medical journals, as appropriate. Once written by the panel, a consensus statement is not subject to subsequent review or approval and does not represent official association opinion. Listed below are recent consensus statements.. Postprandial Blood Glucose ...
An international consensus document on acellular matrix products in the treatment of hard-to-heal wounds such as diabetic foot ulcers, venous leg ulcers and pressure ulcers. Currently there is no definitive paper or guideline on the use of acellular matrices in acute and chronic wounds. To.... ...
The National Consensus Statement: Essential elements for safe and high-quality end-of-life care (the Consensus Statement) was endorsed by Australian Health Ministers in May 2015.. Clinicians, health service executives and managers, policy-makers, educators and training providers can use the principles and ten essential elements of the Consensus Statement as a guide to improving the safety and quality of end-of-life care.. The consensus statement was developed in partnership with health consumers and carers, experts in the field, representatives from public and private hospitals and health services, professional colleges, state and territory health departments, and other government health agencies. Please contact the Commission if you would like more details on the consultation process.. Preliminary scoping work undertaken prior to developing the consensus statement is summarised in Safety and Quality of End-of-Life Care in Acute Hospitals: A Background Paper. This paper presents a précis of the ...
Though recently bolstered by the results of the PIONEER AF-PCI trial, the evidence base on how to manage antithrombotic therapy in patients with A-fib undergoing PCI remains limited and clinical uncertainty abounds. Now, an updated North American consensus document aims to provide some guidance to clinicians wondering what to do with this hard-to-treat population.. Since the last iteration of the document was published in 2011, new evidence regarding the management of antiplatelet and anticoagulant therapies in patients requiring both has emerged in the form of the WOEST and ISAR-TRIPLE trials. PIONEER AF-PCI provides even more information but was released too recently-just 2 weeks ago at the American Heart Association Scientific Sessions-to be incorporated into the new consensus document, which was published online November 1, 2016, ahead of print in Circulation: Cardiovascular Interventions and discussed during a presentation at TCT 2016.. Clinicians have little to go on when deciding how to ...
Most functional test procedures are based on closed skill tasks (eg, single or triple hop, T drill, figure 8 runs), but sport requires open skills in addition to closed skills. Open skills have a reactive element to execute the motor task, usually in addition to decision-making, often in a fatigued state. Therefore, relying on closed skill tasks alone in determining readiness to RTS is not optimal. Gradual and sequential introduction of sport-specific training can be used as functional tests that include an element of protected reactive decision-making (ideally context specific).19-21 Any battery of tests assessing the athletes readiness to RTS should consider both open and closed skills, although in some clinical contexts this may be difficult because of factors including time, space and resources. If this is the case, assessment of closed skills in conjunction with other impairment-based and functional parameters gives the clinician and the athlete a minimum level of information for RTS ...
Lateral ankle sprains (LASs) are the most prevalent musculoskeletal injury in physically active populations. They also have a high prevalence in the general population and pose a substantial healthcare burden. The recurrence rates of LASs are high, leading to a large percentage of patients with LAS …
For the present, TNF blockade should be reserved for patients with RA whose symptoms and signs are resistant to disease modifying antirheumatic drug (DMARD) treatment. It is generally agreed that all patients with active disease should be treated with DMARDs, as such treatment ameliorates symptoms and slows progression of structural damage.2 However, long term efficacy of DMARDs is limited and toxicity accumulates.3 Currently, two TNF-blocking agents, etanercept and infliximab, have received regulatory authority approval for the treatment of RA. Both compounds, alone or in combination with methotrexate, have proved to be successful in significantly reducing inflammatory activity and increasing the quality of life.4-8 In addition, infliximab in combination with methotrexate has been shown to arrest radiographic progression over one year in up to 50% of patients,9 while etanercept has been shown to retard radiographic progression significantly in DMARD-naive patients.10 Nevertheless, in early RA, ...
Future progress on understanding and treating infections caused by equine herpesvirus-1 will depend on research into viral pathogenesis
There is no consensus on the pathologic conditions or severity implied by the term "hippocampal sclerosis" (HS). In this study, a panel of experienced neuropathologists evaluated inter-rater agreement for pathologic diagnoses in the hippocampus and proposes consensus recommendations on the use of the term "HS." In a group of 251 cases of HS selected from a large autopsy cohort (1,388; 18%), a coordinating group identified 5 patterns of degenerative or vascular pathology. Four independent neuropathologists assessed a single set of hematoxylin and eosin-stained sections following descriptive definitions to classify the appearances and assign the diagnosis of HS, if appropriate. Diagnostic agreement (range, 36%-70%) was highest for vascular lesions. Subsequent joint review of all cases highlighted the need to identify neurodegenerative lesions using immunohistochemistry. Initial agreement in assigning the diagnosis of HS varied from 0% to 86%. After a joint review, the group recommended that the ...
Stamatakis and colleagues from University College present comprehensive data about overweight and obesity trends from 1974 to 2003 in English children. The data are disturbing, but not surprising. They mimic information from many other countries. For example, the rates of obesity for boys aged 5-7 years increased from 1.0% in 1974 to 5.2% in 2002-03. For obesity, there was a five to six fold increase for all groups (boys and girls aged 5-7 and 8-10 years), and a near doubling in the prevalence of overweight children (18.5% to 27.1%). Sadly, the rate of change was substantially greater between 2000-01 and 2002-03 than between 1974 and 2000. In a companion perspective, Rudolf, Hochberg, and Speiser describe the conclusions of a recent International Consensus Statement on childhood obesity. The statement addresses definition, preventive strategies, screening, assessment, and treatment. The authors discuss the implications of this statement for the UK.. A recent brouhaha occurred in the US with ...
Leading Diabetes Organizations Issue Consensus Statement Defining Health Outcomes beyond HbA1c --The Type 1 Diabetes Outcomes Program, organized by JDRF, has identified and defined clinically meaningful
Orlandi RR, Kingdom TT, Hwang PH, Smith TL, Alt JA, Baroody FM, Batra PS, Bernal-Sprekelsen M, Bhattacharyya N, Chandra RK, Chiu A, Citardi MJ, Cohen NA, DelGaudio J, Desrosiers M, Dhong HJ, Douglas R, Ferguson B, Fokkens WJ, Georgalas C, Goldberg A, Gosepath J, Hamilos DL, Han JK, Harvey R, Hellings P, Hopkins C, Jankowski R, Javer AR, Kern R, Kountakis S, Kowalski ML, Lane A, Lanza DC, Lebowitz R, Lee HM, Lin SY, Lund V, Luong A, Mann W, Marple BF, McMains KC, Metson R, Naclerio R, Nayak JV, Otori N, Palmer JN, Parikh SR, Passali D, Peters A, Piccirillo J, Poetker DM, Psaltis AJ, Ramadan HH, Ramakrishnan VR, Riechelmann H, Roh HJ, Rudmik L, Sacks R, Schlosser RJ, Senior BA, Sindwani R, Stankiewicz JA, Stewart M, Tan BK, Toskala E, Voegels R, Wang de Y, Weitzel EK, Wise S, Woodworth BA, Wormald PJ, Wright ED, Zhou B, Kennedy DW. International Consensus Statement on Allergy and Rhinology: Rhinosinusitis. Int Forum Allergy Rhinol. 2016 Feb; 6 Suppl 1:S22-209. PMID: 26889651. ...
Management of anaemia and iron deficiency in patients with cancer • Management of infusion reactions to systemic anticancer therapy • Management of toxicities from immunotherapy • Management of febrile neutropaenia • MASCC and ESMO consensus guidelines for the prevention of chemotherapy and radiotherapy-induced nausea and vomiting • Treatment of dyspnoea in advanced cancer patients • Central venous access in oncology • Management of oral and gastrointestinal mucosal injury • Management of refractory symptoms at the end of life and the use of palliative sedation • Advanced care planning in palliative care • Bone health in cancer patients • Cancer, fertility and pregnancy • Management of chemotherapy extravasation • Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy • Management of cancer pain • Management of venous thromboembolism in cancer patients. ...
What should be the recommendations regarding the type (IV versus PO) and length of postoperative antibiotic treatment when a one-stage revision arthroplasty is performed for subacute/chronic shoulder PJI of the shoulder caused by an indolent organism (P. acnes, coag neg staph spec ...
What is the optimal management (Masquelet technique, bone transfer) of post-infective bone defects in different long bones (tibia, femur, humerus etc.)? How does this vary by type of defect (conical vs. cylindrical ...
Since the 2001 update of the American Heart Association (AHA)/American College of Cardiology (ACC) consensus statement on secondary prevention,1 important evidence from clinical trials has emerged that further supports and broadens the merits of aggressive risk-reduction therapies for patients with established coronary and other atherosclerotic vascular disease, including peripheral arterial disease, atherosclerotic aortic disease, and carotid artery disease. This growing body of evidence confirms that aggressive comprehensive risk factor management improves survival, reduces recurrent events and the need for interventional procedures, and improves quality of life for these patients.. Compelling evidence from recent clinical trials and revised practice guidelines provided the impetus for this update of the 2001 recommendations with evidence-based results (Table 1⇓). Classification of Recommendations and Level of Evidence are expressed in ACC/AHA format, as detailed in Tables 2 and 3⇓. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
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The gTLD Registries Stakeholder Group (RySG) is a recognized entity within the Generic Names Supporting Organization (GNSO) formed according to Article X, Section 5 (September 009) of the Internet Corporation for Assigned Names and Numbers (ICANN) Bylaws.. The primary role of the RySG is to represent the interests of gTLD registry operators (or sponsors in the case of sponsored gTLDs) (Registries) (i) that are currently under contract with ICANN to provide gTLD registry services in support of one or more gTLDs; (ii) who agree to be bound by consensus policies in that contract; and (iii) who voluntarily choose to be members of the RySG. The RySG may include Interest Groups as defined by Article IV. The RySG represents the views of the RySG to the GNSO Council and the ICANN Board of Directors with particular emphasis on ICANN consensus policies that relate to interoperability, technical reliability and stable operation of the Internet or domain name system.. The guiding principles for the RySG, ...
Participants: In April 2004, a panel of physicians convened in New York City to discuss recommendations for clinical management of and additional research on SRI discontinuation syndrome. Evidence: Previous guidance for management of SRI discontinuation syndrome was proposed in 1997 in a consensus meeting also chaired by Alan F. Schatzberg. A literature search of the PubMed database was conducted to identify articles on SRI discontinuation syndrome that have been published since 1997 ...
This text was prepared by the Task Force for the Safety of Novel Foods and Feeds to provide an introduction to the consensus documents of the OECDs Task Force. It explains, amongst other things, why the Task Force decided to prepare consensus documents as part of its programme of work. It describes their purpose and their use as a practical contribution to the risk/safety assessment of foods and feeds derived from transgenic. ...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
ORIGINAL ARTICLES International Angiology 2012 August;31(4):316-29. Chronic edema of the lower extremities: international consensus recommendations for compression therapy clinical research trials. Stout N., Partsch H., Szolnoky G., Forner-Cordero I., Mosti G., Mortimer P., Flour M., Damstra R., Piller N., Geyer M. J., Benigni J. P., Moffat C., Cornu-Thenard A., Schingale F., Clark M., Chauveau M. ...
The European Academy of Allergy and Clinical Immunology, EAACI, is an association including 47 European National Societies, more than 8,000 academicians, research investigators and clinicians.
The stock of Ambev SA (ADR) (NYSE:ABEV) gapped up by $0.01 today and has $5.95 target or 3.00% above todays $5.78 share price. The 8 months technical chart setup indicates low risk for the $88.33 billion company. The gap was reported on Apr, 17 by Barchart.com. If the $5.95 price target is reached, the company will be worth $2.65 billion more. About 5.95 million shares traded. Ambev SA (ADR) (NYSE:ABEV) has declined 9.94% since September 8, 2016 and is downtrending. It has underperformed by 16.70% the S&P500.. (Wolcott Daily). Itau Unibanco Holding SA (ADR) (NYSE:ITUB) is currently trading with the volume of 5.62 Million. The Stock opened todays session at $11.97 and currently the price is hovering at $12.36 by showing increase of 4.97 percent. Itau Unibanco Holding S.A. has 1 year price target of $11.67. The stock gained a consensus recommendation of 2 on Zacks Investment Research where the scale runs from 1 to 5, 1 representing Strong buy and 5 showing Strong Sell. The company reported its ...
This consensus document addresses compositional considerations for new varieties of tomato by identifying the key food and feed nutrients, toxicants and allergens. A general description of these components is provided. As well, there is background material on the production, processing and uses of tomato and considerations to be taken when assessing new tomato varieties. Constituents to be analysed, related to food use and to feed. ...
Just hours after Kris Aquino confirmed that she is leaving ABS-CBN, the network released a statement thanking Aquino for her years of service as a Kapamilya.
CSIRO announced days ago that they are growing GM wheat in the ACT, and that they will judge whether its fit for human trials in less than two years, e.g.
This publication provides an overview of the activities of the Expert Group on Future Skills Needs in 2016.. Annual Activity Statement 2016.pdf (size 364.6 KB) ...
No abstract is available; but the full text article can be downloaded by clciking on the link on the right side. This article can be cited as: R. Egel, On the Misgivings of Anthropomorphic Consensus Polling in Defining the Complexity of LifeJ. Biomo
Bitcoin Blasts Through $15,000 - Its A Consensus Hallucination by Tyler Durden Dec 7, 2017 5:13 AM In the last 36 hours, Bitcoin has blasted through $12,000, $13,000, $14,000, and now $15,000 levels in an unprecedented 28% surge...
Bitcoin Blasts Through $15,000 - Its A Consensus Hallucination by Tyler Durden Dec 7, 2017 5:13 AM In the last 36 hours, Bitcoin has blasted through $12,000, $13,000, $14,000, and now $15,000 levels in an unprecedented 28% surge...
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Statements on this website have not been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease. Those seeking treatment for a specific disease should consider consulting a licensed health care provider familiar with natural and holistic products. ...
If the ADJUST=T option is specified in an ESTIMATE statement, and a CONTRAST statement is also specified in PROC GLIMMIX, the contrast results are incorrect.
Select one of the four (4) financial statement analysis reports below to view the ratio analysis report for your selected company ...
Select one of the four (4) financial statement analysis reports below to view the ratio analysis report for your selected company ...
Alnylams third quarter 2013 loss of 48 cents per share was wider than the Zacks Consensus Estimate of a loss of 38 cents per share.
May 5, 2011 (Updated August 1, 2011) - Genetic testing is increasingly important in determining potential cardiac conditions in patients and is used in clinical settings more than ever before. To ensure that physicians have up-to-date knowledge of the evolving role of genetic testing for sudden death predisposing, genetic heart diseases in cardiology, which can be life-saving for some patients, the Heart Rhythm Society and the European Heart Rhythm Association have prepared HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies. The consensus statement was released at Heart Rhythm 2011, the Heart Rhythm Societys 32nd Annual Scientific Sessions.
There is a need for a clear definition of exacerbations used in clinical trials in patients with bronchiectasis. An expert conference was convened to develop a consensus definition of an exacerbation for use in clinical research.. A systematic review of exacerbation definitions used in clinical trials from January 2000 until December 2015 and involving adults with bronchiectasis was conducted. A Delphi process followed by a round-table meeting involving bronchiectasis experts was organised to reach a consensus definition. These experts came from Europe (representing the European Multicentre Bronchiectasis Research Collaboration), North America (representing the US Bronchiectasis Research Registry/COPD Foundation), Australasia and South Africa.. The definition was unanimously approved by the working group as: a person with bronchiectasis with a deterioration in three or more of the following key symptoms for at least 48 h: cough; sputum volume and/or consistency; sputum purulence; breathlessness ...
In a review of research papers published in the period 1966 to 2005, Pluim et al1 showed that reported incidences of tennis injuries ranged over two orders of magnitude (0.04 to 3 injuries/1000 player-hours). Although some of this variation can be accounted for by the different sample populations used in the studies, the authors stated that the main reason for the differences was more likely to be due to the variation in injury definitions and protocols employed in the studies. Consensus statements for cricket,2 football3 and rugby union4 have previously outlined the benefits associated with developing and implementing consistent definitions, data-collection procedures and methods of reporting results in injury surveillance studies. Although these consensus statements were specifically developed for team sports, the International Olympic Committee (IOC) and the International Association of Athletics Federations (IAAF) demonstrated that the principles were also relevant to individual sports.5 6 ...
Abbara S1, Blanke P2, Maroules CD, et al. SCCT guidelines for the performance and acquisition of coronary computed tomographic angiography: A report of the society of Cardiovascular Computed Tomography Guidelines Committee: Endorsed by the North American Society for Cardiovascular Imaging (NASCI). J Cardiovasc Comput Tomogr. 2016;10(6):435-449. PMID: 27780758 www.ncbi.nlm.nih.gov/pubmed/27780758. Abraham NS, Hlatky MA, Antman EM, et al. ACCF/ACG/AHA 2010 Expert Consensus Document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. Circulation. 2010;122(24):2619-2633. PMID: 21060077 www.ncbi.nlm.nih.gov/pubmed/21060077. Brilakis ES, Patel VG, Banerjee S. Medical management after coronary stent implantation: a review. JAMA. ...
Background/Aims: A large amount of new data on the treatment of chronic hepatitis B has become available such that the 2003 consensus statement requires revision and update.. Methods: New data were presented, discussed and debated in an expert pre-meeting to draft a revision. The revised contents were finalized after discussion in a general meeting of APASL.. Results: Conceptual background, including the efficacy and safety profile of currently available and emerging drugs, was reviewed. Nineteen recommendations were formed and unresolved issues and areas for further study were suggested.. Conclusion: The current therapy of chronic hepatitis B is modestly effective but not satisfactory. The development of new drugs and new strategies is required to further improve the outcomes of treatment. ...
Orthopedics Today reported that ankle surgeons around the world met at the International Consensus Meeting on Cartilage Repair of the Ankle, where they discussed the best ways to treat ankle cartilage injuries and established a consensus for all surgeons. John G. Kennedy, MD, foot and ankle surgeon at HSS and co-founder of the International Soc...
WASHINGTON, D.C., and DALLAS (March 17, 2014) - The increasing number of percutaneous coronary interventions (PCIs) being performed at low-volume centers without on-site cardiac surgery backup has driven the need for new safety and quality protocols, according to an expert consensus document released today and written by a committee representing the Society for Cardiovascular Angiography and Interventions (SCAI), the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA). The document outlines steps hospitals can take to provide the safest possible environment for PCI when the facility does not provide cardiac surgery as a backup should complications occur.
Therefore, European Liver Patients Association (ELPA) invited leading psychologists, psychiatrists and hepatologists to an expert conference in 2011. Martin Schaefer MD and his colleagues reviewed the scientific data and discussed their experience in the treatment of hepatitis C related psychiatric problems. The results were first presented at the EASL conference in Berlin in 2011. Since the conference, the recommendations were refined and updated further to include the new antiviral treatments, and will now be published as a "European Expert Consensus Statement" in the Journal of Hepatology ...
October 15, 2012 -- The European Society of Gastrointestinal and Abdominal Radiology (ESGAR) has published its first update on CT colonography (CTC) guidelines since 2007. Its working group on CTC has endorsed 86 statements, reaching near-complete agreement on 71 of the 86 items relating to critical practice areas affecting CTC.. Agreement was most consistent in the areas of colon distension, scan parameters, use of intravenous contrast agents, patient preparation, and the role of computer-aided detection (CAD) and lesion measurement. Less than unanimous accord was seen in the use of spasmolytics, decubitus positioning and the number of CT data acquisitions, fecal tagging, 2D versus 3D reading, and reporting.. "Over the last five years, expansion of the CT colonography literature has continued and several important studies, including multicenter studies, have been published," wrote Dr. Emanuele Neri and colleagues from six EU countries on behalf of the ESGAR CTC working group. "These new data ...
TY - JOUR. T1 - International consensus on preliminary definitions of improvement in adult and juvenile myositis. AU - Rider, Lisa G.. AU - Giannini, Edward H.. AU - Brunner, Hermine I.. AU - Ruperto, Nicola. AU - James-Newton, Laura. AU - Reed, Ann M.. AU - Lachenbruch, Peter A.. AU - Miller, Frederick W.. PY - 2004/7. Y1 - 2004/7. N2 - Objective. To use a core set of outcome measures to develop preliminary definitions of improvement for adult and juvenile myositis as composite end points for therapeutic trials. Methods. Twenty-nine experts in the assessment of myositis achieved consensus on 102 adult and 102 juvenile paper patient profiles as clinically improved or not improved. Two hundred twenty-seven candidate definitions of improvement were developed using the experts consensus ratings as a gold standard and their judgment of clinically meaningful change in the core set of measures. Seventeen additional candidate definitions of improvement were developed from classification and regression ...
Make better use of current drugs and treat as soon as possible, says Dr Alexandre Mebazaa, lead author of new European recommendations on acute heart failure.
Roy Freeman;Wouter Wieling;Felicia Axelrod;David Benditt;Eduardo Benarroch;Italo Biaggioni;William Cheshire;Thomas Chelimsky;Pietro Cortelli;Christopher Gibbons;David Goldstein;Roger Hainsworth;Max Hilz;Giris Jacob;Horacio Kaufmann;Jens Jordan;Lewis Lipsitz;Benjamin Levine;Phillip Low;Christopher Mathias;Satish Raj;David Robertson;Paola Sandroni;Irwin Schatz;Ron Schondorff;Julian Stewart;Gert van Dijk; + Author Information ...
ADI aims to provide the public with an improved understanding of the benefits of implantology, and Members with the benefits of continuous skills development and safeguarding of standards.
August 28, 2013 - Experts have found that radiation dosage can have serious complications for patients with cancer. Cancer patients who receive chest radiation should be evaluated for heart disease before beginning radiation, and every five to 10 years afterward, according to the American Society of Echocardiography (ASE) and the European Assn. of Cardiovascular Imaging (EACVI) of the European Society of Cardiology (ESC). This expert consensus statement on the use of imaging to detect radiation-induced heart disease (RIHD) will be published in the September issue of the Journal of the American Society of Echocardiography (JASE). The writing group was co-chaired by Vuyisile Nkomo, M.D., an echocardiographer from the renowned Mayo Clinic in Rochester, Minn.. When asked about the need for this expert consensus statement, Nkomo said, "In the past, patients received high doses of radiation to the chest to treat breast cancer or lymphoma or esophageal cancer, but without adequate shielding of the ...
Table of Contents Table of Contents 1. Introduction 2. Consensus Statements on Ridge Augmentation and Review of the Literature 2.1. Consensus Statements and Treatment Guidelines Formulated at the 2008 ITI Consensus Conference 2.1.1. Consensus Statement...
Health,... Patient safety in hospitals focus of 48 NQF-endorsed measures ...WASHINGTON May 15 -- Recognizing that patient... It has been difficult to make real progress in patient safety in this...NQF-endorsed voluntary consensus standards are widely viewed as the g...,National,Quality,Forum,Endorses,Consensus,Standards,for,Quality,of,Hospital,Care,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
BACKGROUND AND PURPOSE: Transcranial color-coded duplex sonography has become a standard diagnostic technique to assess the intracranial arterial status in acute stroke. It is increasingly used for the evaluation of prognosis and the success of revascularization in multicenter trials. The aim of this international consensus procedure was to develop recommendations on the methodology and documentation to be used for assessment of intracranial occlusion and for monitoring of recanalization. METHODS: Thirty-five experts participated in the consensus process. The presented recommendations were approved during a meeting of the consensus group in October 2008 in Giessen, Germany. The project was an initiative of the German Competence Network Stroke and performed under the auspices of the Neurosonology Research Group of the World Federation of Neurology. RESULTS: Recommendations are given on how examinations should be performed in the time-limited situation of acute stroke, including criteria to assess ...
Governmental and private organizations often develop recommendations for the prevention, diagnosis, and treatment of various disorders. These recommendations regarding appropriate clinical decisions are usually made by a group of experts after they assess the available evidence. Recommendations may be published as consensus statements developed at a conference or as clinical practice guidelines (sometimes called practice parameters) developed over time. In either case, publication of the recommendations should identify the sponsor and the participating experts, explain how the participants were selected, describe the evidence that supports the recommendations, and explain the process for achieving consensus in reaching the conclusions. Structured abstracts
CIPO is pleased to be part of a coalition of Canadian Patient organizations that came together through the International Federation on Ageing (IFA), to discuss adult influenza vaccination. On September 5 the IFA is pleased to release the consensus statement Uniting Diverse Groups to Improve Adult Influenza Vaccination in Canada as a result of the "Adult Influenza Vaccination: Calling Canadian Patient Organizations to Action" expert meeting held in June 2019. This consensus statement is an important step forward in forming a cohesive voice that supports improvements in vaccination practices in Canada.. Press Release - Consensus Statement. Consensus Statement - Uniting Diverse Groups to Improve Adult Influenza Vaccination. ...
TY - JOUR. T1 - Comparison of four methods for assessing the importance of attitudinal beliefs. T2 - An international Delphi study in intensive care settings. AU - Francis, Jill J. AU - Duncan, Eilidh M. AU - Prior, Maria E. AU - Maclennan, Graeme. AU - Marshall, Andrea P. AU - Wells, Elisabeth C. AU - Todd, Laura. AU - Rose, Louise. AU - Campbell, Marion K. AU - Webster, Fiona. AU - Eccles, Martin P. AU - Bellingan, Geoff. AU - Seppelt, Ian M. AU - Grimshaw, Jeremy M. AU - Cuthbertson, Brian H. AU - for the SuDDICU study groups. N1 - © 2013 The British Psychological Society.. PY - 2014/5. Y1 - 2014/5. N2 - Behaviour change interventions often target important beliefs. The literature proposes four methods for assessing importance of attitudinal beliefs: elicitation frequency, importance ratings, and strength of prediction (bivariate and multivariate). We tested congruence between these methods in a Delphi study about selective decontamination of the digestive tract (SDD). SDD improves ...
Recommendations for the practical management of CRT patients have been set out for the first time in an international consensus statement on cardiac resynchronization therapy (CRT) in heart failure.
TY - JOUR. T1 - Position Paper on laboratory testing for patients on direct oral anticoagulants. A Consensus Document from the SISET, FCSA, SIBioC and SIPMeL. AU - Tripodi, Armando. AU - Ageno, Walter. AU - Ciaccio, Marcello. AU - Legnani, Cristina. AU - Lippi, Giuseppe. AU - Manotti, Cesare. AU - Marcucci, Rossella. AU - Moia, Marco. AU - Morelli, Benedetto. AU - Poli, Daniela. AU - Steffan, Agostino. AU - Testa, Sophie. PY - 2018/9. Y1 - 2018/9. N2 - Although direct oral anticoagulants (DOAC) do not require dose-adjustment on the basis of laboratory test results, the measurement of their anticoagulant effect is useful in special situations. This position paper issued by the Italian Scientific Societies that are mainly involved in the management of patients on DOAC is aimed at providing guidance to care-givers on which tests should be used and the situations in which testing is useful. The guidance is based on the data from the literature so far available and/or on consensus among ...
Barnhart K, van Mello NM, Bourne T, Kirk E, Van Calster B, Bottomley C, Chung K, Condous G, Goldstein S, Hajenius PJ, Mol BW, Molinaro T, OFlynn OBrien KL, Husicka R, Sammel M, Timmerman D. Pregnancy of unknown location: A consensus statement of nomenclature, definitions, and outcome. Fertil Steril 2011; 95(3): 857-866. PMCID: PMC 3032825. U.S. National Library of Medicine abstract ...
Peters SE, Johnston V, Coppieters M, and Ross M. Journal of Hand Surgery (European Volume) 2017; 42(2):127-136. DOI: 10.1177/1753193416669263 This Delphi study aimed to reach consensus on important facilitators and barriers for return-to-work (RTW) following surgery for non-traumatic upper extremity (UE) conditions. In Round 1, experts (n=42) listed 134 factors, which were appraised in Round [...] ...
Home , International guidelines for the selection of lung transplant candidates: 2006 update--a consensus report from the Pulmonary Scientific Council of the International Society for Heart and Lung ...
Despite the fact that PCR for the detection of Aspergillus in human specimens exists for almost two decades, the technique was not included in the European Organisation for Research and Treatment of Cancer and the Mycoses Study Group (EORTC/MSG) consensus definitions for diagnosing invasive fungal diseases (IFD) because of the lack of standardisation. In 2006, the UK Fungal PCR Consensus group published an agreed methodology for PCR aided diagnosis of IA within the UK and Ireland. Then, at the meeting of the International Society for Human and Animal Mycoses (ISHAM) in Paris in September 2006, a group of mainly European experts founded the European Aspergillus PCR Initiative (EAPCRI) involving more than 60 centres across Europe and centres in Australia and the Middle East.. The EAPCRI agreed to collaborate to develop a standard for Aspergillus PCR methodology and to validate this in clinical trials so that PCR could be incorporated into future consensus definitions for diagnosing IFD.. The ...
A medical guideline (also called a clinical guideline, clinical protocol or clinical practice guideline) is a document with the aim of guiding decisions and criteria regarding diagnosis, management, and treatment in specific areas of healthcare. Such documents have been in use for thousands of years during the entire history of medicine.. However, in contrast to previous approaches, which were often based on tradition or authority, modern medical guidelines are based on an examination of current evidence within the paradigm of evidence-based medicine. They usually include summarized consensus statements on best practice in healthcare. A healthcare provider is obliged to know the medical guidelines of his or her profession, and has to decide whether or not to follow the recommendations of a guideline for an individual treatment.. Modern clinical guidelines identify, summarize and evaluate the highest quality evidence and most current data about prevention, diagnosis, prognosis, therapy including ...
On 22 April 2010, Australian Health Ministers endorsed the National Consensus Statement: Essential Elements for Recognising and Responding to Clinical Deterioration (PDF 1013 kb) as the national approach for recognising and responding to clinical deterioration in Australian acute care facilities.. Healthcare facilities need to have systems in place that address all elements of the Consensus Statement to ensure that all patients who deteriorate receive a timely and appropriate treatment response. A suite of resources has been developed to support healthcare organisations to implement recognition and response systems:. ...
The journal focuses on neuroimmunology and neuroinflammation, and the coverage extends to other basic and clinical studies related to neuroscience including molecular biology, psychology, pathology, physiology, endocrinology, pharmacology, oncology, etc.
It was lost on no one that the Comedy Central faux news anchor delivered his off-color rant against the backdrop of the House canceling floor votes for the rest of this week as Democratic leaders struggle to reach consensus on how to move a simple stopgap spending bill that will prevent the government from shutting down on Oct. 1 ...
Until recently, there has been controversy regarding the classification of OVMs, which reflects a poor understanding of the origin of these lesions and may complicate treatment decisions. In 1999 the Orbital Society published a consensus statement on the terminology of OVMs [2]. Vascular malformations were classified as no flow malformations (e.g. lymphangiomas), arterial flow malformations (e.g. arteriovenous malformations) or venous flow malformations according to communications with the systemic vascular system. Venous flow malformations are weakened segments of the orbital venous system of variable complexity. This group is further classified as distensible (clinical or radiological evidence of distensibility with increased venous pressure), or nondistensible. Distensible lesions have direct and rich communication with the venous circulation and nondistensible lesions have a direct communication but to a much lesser extent ...
The Peoples Charter for Health is a statement of the shared vision, goals, principles and calls for action that unite all the members of the PHM coalition. It is most widely endorsed consensus document on health since the Alma Ata Declaration. The Peoples Health Charter was formulated and endorsed by the participants of the First Peoples Health Assembly held at Dhaka, Bangladesh in December 2000.. In 1978, at the Alma-Ata Conference, ministers from 134 countries in association with WHO and UNICEF called for Health for All by the Year 2000 and selected Primary Health Care as the best tool to achieve it.. Unfortunately, that dream never came true. The health status of Third World populations has not improved. In many cases it has deteriorated further. Currently, we are facing a global health crisis, characterised by growing inequalities within and between countries. New threats to health are continually emerging. This is compounded by negative forces of globalisation which prevent the ...
INTRODUCTION: Emergency general surgery (EGS) is responsible for 80-90% of surgical in-hospital deaths and the early management of these unwell patients is critical to improving outcomes. Unfortunately care for EGS patients is often fragmented and important care processes are frequently omitted. METHODS: This study aimed to define a group of important processes during EGS admission and assess their reliability. Literature review and semi-structured interviews were used to define a draft list of processes, which was refined and validated using the Delphi consensus methodology. A prospective cohort study of the 22 included processes was performed in 315 patients across 5 acute hospitals. RESULTS: Prospective study of the 22 selected processes demonstrated omission of 1130/5668 (19.9%) processes. Only 6 (1.9%) patients had all relevant processes performed correctly. Administration of oxygen to hypoxic patients (82/129, 64%), consultant review (202/313, 65%) and administration of antibiotics within 3 h for
The gTLD Registries Stakeholder Group (RySG) is a recognized entity within the Generic Names Supporting Organization (GNSO) formed according to Article X, Section 5 (September 2009) of the Internet Corporation for Assigned Names and Numbers (ICANN) Bylaws.. The primary role of the RySG is to represent the interests of gTLD registry operators (or sponsors in the case of sponsored gTLDs) ("Registries") (i) that are currently under contract with ICANN to provide gTLD registry services in support of one or more gTLDs; (ii) who agree to be bound by consensus policies in that contract; and (iii) who voluntarily choose to be members of the RySG. The RySG may include Interest Groups as defined by Article IV. The RySG represents the views of the RySG to the GNSO Council and the ICANN Board of Directors with particular emphasis on ICANN consensus policies that relate to interoperability, technical reliability and stable operation of the Internet or domain name system.. The guiding principles for the RySG, ...
OBJECTIVE: To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS).. METHODS: At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants.. RESULTS: We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted 24 focus groups with 130 patients from 7 countries representing 5 continents to identify patient domains. We achieved consensus through 2 rounds of separate surveys with 50 patients and 75 physicians, and a nominal group technique meeting with 12 patients and 12 physicians. We conducted a workshop and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA ...
on a variety of topics of interest to the environmental measurement community. TNI also hosts two regularly scheduled meetings per year, typically in January and August. Both are a week long and involve open meetings of TNI committees as well as training courses and other special sessions.. ...
This standard is relevant to medical devices and is recognized on its scientific and technical merit and/or because it supports existing regulatory policies. ...
How do you think these new selection criteria might potentially impact current clinical practice?. Evidence-based guidelines have the potential to change clinical practice and further validate the safety and efficacy of APBI. I believe lowering the age should continue to expand the number of eligible patients who can benefit from APBI. This increase could go as high as 20 to 30% in some cases.. In regards to APBI techniques, how were the recommendations ranked?. The recommendations were based on a systematic review of 7 randomized and 5 prospective trials. Each technique was reviewed and assigned a ranking of evidence that ranges from strong to weak and includes a recommendation on utilization of either off and on protocol or strictly on protocol.. Which APBI techniques are recommended by the society for general use and why? Interstitial brachytherapy has an impressive body of long-term follow up and randomized data however it is the most technically complex to perform. Applicator based ...
Nevertheless, our study has at least seven limitations. Firstly, the investigators knew the results of the Manchester study in which SB, who moderated the NZ meetings, was involved. However, the NZ panel did not know these results (which had not yet been published) nor did they know that the criteria rated in round 2 in the UK had been used to inform the criteria they were asked to rate in round 1 in NZ. Previous assessments of interpanel reliability have involved panels in rating the same criteria, although from round 1.13 29. Secondly, we revised the wording of the appropriateness scale used in the Manchester study. However, we changed the description of the task rather than the task itself, and very few final criteria describe inappropriate actions. Almost all the criteria reported in our study and the UK study result from necessity ratings on a scale that was identical in both studies. Consequently, this paper has focused mainly on the necessity criteria.. Thirdly, we have assumed that the ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
We assist in providing health education to villages. Primarily in the area of water, hygiene, sanitation and diarrhoea management. - hetv.org
In 2000, the American Thoracic Society and European Respiratory Society published an international consensus statement with guidelines for the diagnosis and treatment of IPF [6]. The guidelines recommended that until adequate studies were conducted to define the best treatment for patients with IPF, they should be treated with a combined therapy of corticosteroids and an immunosuppressive agent (e.g. azathioprine or cyclophosphamide). In 2003, a Cochrane review was published on the use of corticosteroids in IPF [7]. This review highlighted that there were no placebo-controlled clinical trials analysing the efficacy of corticosteroid therapy in IPF patients and, therefore, there was no existing evidence to support the efficacy of corticosteroids alone in the treatment of IPF.. Moreover, Davies et al. [8] published a Cochrane review in 2003 on the use of immunomodulatory agents in IPF. The authors found four randomised controlled clinical studies suitable for a meta-analysis [9-12]; however, these ...
Regarding [http://wikitravel.org/wiki/en/index.php?title=Wikitravel_talk:Deletion_policy&diff=prev&oldid=1031686], the purpose of discussions is not for people to "take sides". Its to attempt to reach consensus through addressing others arguments and attempting to find common ground. Feel free to delete this message, Ill know that youve read it (-: Cheers, JYolkowski 18:13, 8 January 2009 (EST) :I do know it is not about sides per se. And I am not keeping count on whos on what side all I am saying is that everyone was on Peters side or ignoring it but now there is real discussion and people are saying no to Peter thankfully. color="#339989">edmontonenthusiast [ee</font>]] <sup><small><font color="#8848d7">.T.A.L.K.</font></small></sup> 18:15, 8 January 2009 (EST).
The European Cystic Fibrosis Society is an international community of scientific and clinical professionals committed to improving survival and quality of life for people with CF by promoting high quality research, education and care.
Methods Recommendations were developed by a group of 40 specialists made up of rheumatologists and members of other medical disciplines. A systematic review of articles, meta-analyses and guidelines for the management of hand, hip and knee OA published from 2008 and January 2014 was done. The level of evidence and strength of recommendation were classified according to the Jadad scale (3).The level of agreement was established through a Delphi technique. ...
Sanderson, Tessa and Morris, Marianne and Calnan, Michael .W. and Richardson, P.J. and Hewlett, Sarah (2008) The use of nominal groups to develop a patient-generated core set of treatment outcomes in rheumatoid arthritis. Arthritis and Rheumatism , 58 (9). S863-S863. ISSN 0004-3591. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) ...
In the past several decades, the importance of careful scientific evaluation of routines of care has been recognized. The use of traditional "expert consensus" methods of developing clinical recommendations has given way to a systematic and explicit process for reviewing evidence and linking recommendations directly to the quality of the scientific findings.102-104 The CTF and USPSTF grew out of this new understanding. Increasing sophistication of the process of systematic review has led to the use of explicit strategies for searching for and evaluating evidence.. Of the recommendations reviewed for this report, those of the USPSTF, the CTF, and the AAFP are explicitly based on systematic reviews of the evidence. GAPS and the ICSI state that evidence was reviewed, but the methods and content of the evidence reviews are not available for independent appraisal. Recommendations of the AAP and Bright Futures are based on expert consensus, without explicit reference to the evidence. We found widely ...
Khong TY, Mooney EE, Ariel I, Balmus NC, Boyd TK, Brundler MA, Derricott H,Evans MJ, Faye-Petersen OM, Gillan JE, Heazell AE, Heller DS, Jacques SM, KeatingS, Kelehan P, Maes A, McKay EM, Morgan TK, Nikkels PG, Parks WT, Redline RW,Scheimberg I, Schoots MH, Sebire NJ, Timmer A, Turowski G, van der Voorn JP, van Lijnschoten I, Gordijn SJ. Sampling and Definitions of Placental Lesions:Amsterdam Placental Workshop Group Consensus Statement. Arch Pathol Lab Med. 2016Jul;140(7):698-713. doi: 10.5858/arpa.2015-0225-CC. Epub 2016 May 25. PubMedPMID: 27223167. https://www.ncbi.nlm.nih.gov/pubmed/27223167 ...
The quality of health care in the United States varies greatly.1-3 A study in 2003 showed that Americans receive "recommended care" just over 50% of the time.4 In response to growing national consensus among key provider, payer, and employer stakeholders about the inadequate pace of change, the Institute for Healthcare Improvement launched the 100 000 Lives Campaign in December 2004. Since then the institute, a not-for-profit organisation whose mission is to accelerate the improvement of health care in the US and internationally, has engaged over 3000 US hospitals (representing over 80% of total US hospital discharges) in this national initiative. The campaign aims to avoid 100 000 unnecessary deaths in US hospitals over the 18 months from January 2005 to June 2006, largely through encouraging and helping hospitals to adopt six evidence based interventions that are known to significantly reduce harm and death when implemented reliably (box 1).56 ...
Journal of Medical Internet Research - International Scientific Journal for Medical Research, Information and Communication on the Internet
This Web site provides information and clinical tools from the PEACE (Prepare, Embrace, Attend, Communicate, and Empower) Project. The PEACE Project developed quality measures for hospice and palliative care organizations to assess quality of care and target areas for improvement. The tools, covering all domains of quality of care included in the National Consensus Project for Quality Palliative Care and endorsed by the National Quality Forum, include:. ...
This document brings together essential knowledge about infant and young child feeding that health professionals should acquire. It focuses on nutritional needs and feeding practices in children less than two years of age. ...
The Consensus Document on Alternatives to Allogenic Blood Transfusion (AABT) has been drawn up by a panel of experts from 5 scientific societies. The Seville Consensus Document on Alternatives to Allogenic Blood Transfusion
TY - JOUR. T1 - 2012 American College of Cardiology Foundation/Society for Cardiovascular Angiography and Interventions Expert Consensus Document on Cardiac Catheterization Laboratory Standards update. T2 - A report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. AU - Bashore, Thomas M.. AU - Balter, Stephen. AU - Barac, Ana. AU - Byrne, John G.. AU - Cavendish, Jeffrey J.. AU - Chambers, Charles E.. AU - Hermiller, James Bernard. AU - Kinlay, Scott. AU - Landzberg, Joel S.. AU - Laskey, Warren K.. AU - McKay, Charles R.. AU - Miller, Julie M.. AU - Moliterno, David J.. AU - Moore, John W.M.. AU - Oliver-Mcneil, Sandra M.. AU - Popma, Jeffrey J.. AU - Tommaso, Carl L.. PY - 2012/6/12. Y1 - 2012/6/12. N2 - The last expert consensus document on cardiac catheterization laboratory standards was published in 2001 (1). Since then, many changes have occurred as the setting has evolved from being primarily diagnostic based into a therapeutic environment. ...
2012 Writing Committee Members, Jneid H, Anderson JL, et al. 2012 ACCF/AHA focused update of the guideline for the management of patients with unstable angina/Non-ST-elevation myocardial infarction (updating the 2007 guideline and replacing the 2011 focused update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on practice guidelines. Circulation. 2012;126(7):875-910. PMID: 22800849 www.ncbi.nlm.nih.gov/pubmed/22800849. Abraham NS, Hlatky MA, Antman EM, et al. ACCF/ACG/AHA 2010 Expert Consensus Document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. Circulation. 2010;122(24):2619-2633. PMID: 21060077 www.ncbi.nlm.nih.gov/pubmed/21060077. American College of Emergency Physicians; ...
Thienopyridine therapy has been evaluated as an alternative to or in addition to aspirin treatment ("dual antiplatelet therapy") to reduce CV events. The absolute risk reduction from thienopyridines is greater in patients at higher CV risk, particularly those with acute coronary syndromes (ACS) or patients who have had a coronary stent implanted.. In patients with ACS without ST-segment elevation, dual antiplatelet therapy with clopidogrel plus aspirin reduced the risk of cardiac death, myocardial infarction (MI), or stroke from 11.4% to 9.3%, compared with aspirin alone, irrespective of whether patients were revascularized or treated medically3 but increased major bleeding from 2.7% to 3.7%. In patients with ST-segment elevation MI treated with fibrinolytics, the addition of clopidogrel to aspirin reduced major CV events over 30 days from 10.9% to 9.1% but increased major bleeding from 1.7% to 1.9%.4,5. Dual antiplatelet therapy with aspirin and clopidogrel reduces stent thrombosis following ...
DNAH5: dynein, axonemal, heavy chain 5 gene; DNAI1: dynein, axonemal, intermediate chain 1 gene; DNAH11: dynein, axonemal, heavy chain 11 gene; TXNDC3: thioredoxin domain containing 3 (spermatozoa) gene; DNAI2: dynein, axonemal, intermediate chain 2 gene; KTU: chromosome 14 open reading frame 104 gene; RPGR: retinitis pigmentosa guanosine triphosphatase regulator gene; OFD1: oral-facial-digital syndrome 1 gene; RSPH9: radial spoke head 9 homologue (Chlamydomonas) gene; RSPH4A: radial spoke head 4 homologue A (Chlamydomonas) gene; ODA: outer dynein arm; IDA: inner dynein arm; CP: central pair; c.: cDNA sequence; del: deletion; T: thymidine; IVS: intervening sequence; ins: insertion; G: guanine; A: adenine; KS: Kartageners syndrome. ...
TY - JOUR. T1 - Kyoto global consensus report on Helicobacter pylori gastritis. AU - faculty members of Kyoto Global Consensus Conference. AU - Sugano, Kentaro. AU - Tack, Jan. AU - Kuipers, Ernst J.. AU - Graham, David Y.. AU - El-Omar, Emad M.. AU - Miura, Soichiro. AU - Haruma, Ken. AU - Asaka, Masahiro. AU - Uemura, Naomi. AU - Malfertheiner, Peter. AU - Azuma, Takeshi. AU - Bazzoli, Franco. AU - Chan, Francis Ka Leung. AU - Chen, Minhu. AU - Chiba, Naoki. AU - Chiba, Tsutomu. AU - Vas Coelho, Luiz Gonzaga. AU - Di Mario, Francesco. AU - Fock, Kwong Ming. AU - Fukuda, Yasuhiro. AU - Genta, Robert Maximilian. AU - Goh, Khean Lee. AU - Katelaris, Peter Harry. AU - Kato, Mototsugu. AU - Kawai, Takashi. AU - Kushima, Ryuji. AU - Mahachai, Varocha. AU - Matsuhisa, Takeshi. AU - Miwa, Hiroto. AU - Murakami, Kazunari. AU - OMorain, Colm Antoine. AU - Rugge, Massimo. AU - Sato, Kiichi. AU - Shimoyama, Tadashi. AU - Sugiyama, Toshiro. AU - Suzuki, Hidekazu. AU - Yagi, Kazuyoshi. AU - Wu, Ming ...
Heats stroke (HS) is severe sunstroke caused by a rapid increase in ones core temperature in excess of 40 °C from exposure to a hot and humid environment. HS is accompanied by serious clinical syndromes that damage multiple organ systems. These syndromes include burning skin and impaired awareness, such as delirium, convulsions, and loss of consciousness.. Exertional heat stroke (EHS) is caused by a rapid increase in ones core temperature in excess of 40 °C from high intensity physical exercise in a hot and humid environment. EHS is accompanied by extremely serious clinical syndromes that damage multiple organs and multiple systems. Syndromes include impaired awareness, rhabdomyolysis, disseminated intravascular coagulation (DIC), acute liver damage, and acute renal damage. EHS is the most severe type of sunstroke and is characterized by acute onset and rapid progression The case fatality rate can reach more than 50 % if effective treatment is not received in a timely manner. EHS is commonly ...
Preface, vii List of contributors, ix. VeniceChart task force composition, xxxiii. List of abbreviations, xxxvii. 1 Anatomy of structures relevant to atrial fibrillation ablation, 1. 2 Pathophysiology of atrial fibrillation, 20. 3 Techniques and technologies for atrial fibrillation catheter ablation, 35. 4 Endpoints of catheter ablation for atrial fibrillation, 61. 5 Patient management pre-, during-, and postablation, 70. 6 Periprocedural and long-term anticoagulation, 77. 7 Periprocedural and late complications, 85. 8 Short- and long-term efficacy of catheter ablation procedures for atrial fibrillation, 118. 9 Indications to atrial fibrillation ablation and cost-effectiveness, 127. 10 Clinical trials on atrial fibrillation/future perspectives, 137. 11 Surgical approach/ablation, 161. 12 Hospital equipment and facilities, personnel, training requirements, and competences, 176. Index, 184. ...

A Comeback for VBAC? - Cesarean RatesA Comeback for VBAC? - Cesarean Rates

Institutes of Health Consensus Development Conference in Bethesda, MD to explore the precipitous drop in vaginal birth after ... Both the NIH Consensus and the ACOG Practice Bulletin concurred that a majority of women with a prior cesarean delivery (CD) ... Potential VBAC candidates should be given access to the recent NIH Consensus Statement and ACOG guidelines. Many women have ... The year 2010 saw the gathering of national experts at the National Institutes of Health Consensus Development Conference in ...
more infohttps://www.cesareanrates.com/unnecesareanblogarchive/2011/5/11/a-comeback-for-vbac.html

ANA PatternsANA Patterns

Nuclear speckled pattern with striking variability in intensity with the strongest staining in G2 phase and weakest/negative staining in G1. The centromeres are positive only in prometaphase and metaphase, revealing multiple aligned small and faint dots. Prometaphase cells frequently show a weak staining of the nuclear envelope. During anaphase and telophase, some sera demonstrate intense staining in the ring located at the midzone (i.e. mid-body, stem body) where the division of the daughter cells is taking place. The surrounding cytoplasm of the mitotic cells is diffusely stained ...
more infohttps://anapatterns.org/nuclear_patterns.php

That Scientific Global Warming Consensus...Not!That Scientific Global Warming Consensus...Not!

Consensus momentum regarding action on climate change? Phony, contrived talking points, unscientific propositions, and a scorn ... Consensus momentum regarding action on climate change? Phony, contrived talking points, unscientific propositions, and a scorn ... So where did that famous "consensus" claim that "98% of all scientists believe in global warming" come from? It originated from ... So where did that famous "consensus" claim that "98% of all scientists believe in global warming" come from? It originated from ...
more infohttps://www.forbes.com/sites/larrybell/2012/07/17/that-scientific-global-warming-consensus-not/?commentId=comment_blogAndPostId/blog/comment/1302-1222-2154

That Scientific Global Warming Consensus...Not!That Scientific Global Warming Consensus...Not!

Consensus momentum regarding action on climate change? Phony, contrived talking points, unscientific propositions, and a scorn ... Consensus momentum regarding action on climate change? Phony, contrived talking points, unscientific propositions, and a scorn ... So where did that famous "consensus" claim that "98% of all scientists believe in global warming" come from? It originated from ... So where did that famous "consensus" claim that "98% of all scientists believe in global warming" come from? It originated from ...
more infohttps://www.forbes.com/sites/larrybell/2012/07/17/that-scientific-global-warming-consensus-not/?commentId=comment_blogAndPostId/blog/comment/1302-1222-2155

Consensus Statements | Diabetes CareConsensus Statements | Diabetes Care

A consensus statement is a comprehensive analysis by a panel of experts (i.e., consensus panel) of a scientific or medical ... A consensus statement is developed immediately after a consensus conference at which presentations are made on the issue under ... Proceedings of a Consensus Development Conference on Standardized Measures in Diabetic Neuropathy Diabetes Care 15:1080-1107, ... The need for a consensus statement arises when clinicians or scientists desire guidance on a subject for which there is a ...
more infohttp://care.diabetesjournals.org/content/26/suppl_1/s148

SOSORT consensus & guidelines articlesSOSORT consensus & guidelines articles

SOSORT consensus paper: school screening for scoliosis. Where are we today? This report is the SOSORT Consensus Paper on School ... SOSORT 2012 consensus paper: reducing x-ray exposure in pediatric patients with scoliosis This 2012 Consensus paper reviews the ... 8th SOSORT consensus paper This report is the SOSORT Consensus Paper on Terminology for use in the treatment of conservative ... SOSORT 2005 Consensus paper Medicine is a scientific art: once science is not clear, choices are made according to individual ...
more infohttps://www.biomedcentral.com/collections/sosort

Consensus Estimate - BarronsConsensus Estimate - Barron's

Day Time Consensus Est Last PeriodT 10:00 April Consumer Confidence 105.0% 107.2%10:00 March Existing Home Sales 6.40 mil 6.69 ...
more infohttps://www.barrons.com/articles/SB117704186979876662

DNA consensus seqsDNA consensus seq's

DNA consensus seqs. Mike Cherry cherry at GENOME.STANFORD.EDU Tue Oct 5 18:48:43 EST 1993 *Previous message: DNA consensus ...
more infohttp://www.bio.net/bionet/mm/yeast/1993-October/000399.html

The Consensus ProjectThe Consensus Project

... TCP Home. My Ratings. Rate Abstracts. FAQ. Visualization. Search. ...
more infohttps://skepticalscience.com/tcp.php?p=14&t=8269&t=search&s=a&c=&e=4

CCDS Report for Consensus CDSCCDS Report for Consensus CDS

The CCDS database identifies a core set of human protein coding regions that are consistently annotated by multiple public resources and pass quality tests.
more infohttps://www.ncbi.nlm.nih.gov/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS14529.1

CCDS Report for Consensus CDSCCDS Report for Consensus CDS

The CCDS database identifies a core set of human protein coding regions that are consistently annotated by multiple public resources and pass quality tests.
more infohttps://www.ncbi.nlm.nih.gov/CCDS/CcdsBrowse.cgi?REQUEST=CCDS&GO=MainBrowse&DATA=CCDS17318.1

Obstetric Care Consensus Series - ACOGObstetric Care Consensus Series - ACOG

Abstract: In 2011, one in three women who gave birth in the United States did so by cesarean delivery. Cesarean birth can be life-saving for the fetus, the mother, or both in certain cases. However, the rapid increase in cesarean birth rates from 1996 to 2011 without clear evidence of concomitant decreases in maternal or neonatal morbidity or mortality raises significant concern that cesarean delivery is overused. Variation in the rates of nulliparous, term, singleton, vertex cesarean births also indicates that clinical practice patterns affect the number of cesarean births performed. The mos... ...
more infohttps://www.acog.org/Clinical-Guidance-and-Publications/Obstetric-Care-Consensus-Series?DateRange=olderthansixmonths&Topics=16779859-83fb-4663-ae3a-6d1651db79f2

Obstetric Care Consensus Series - ACOGObstetric Care Consensus Series - ACOG

ABSTRACT: Approximately 0.5% of all births occur before the third trimester of pregnancy, and these very early deliveries result in the majority of neonatal deaths and more than 40% of infant deaths. A recent executive summary of proceedings from a joint workshop defined periviable birth as delivery occurring from 20 0/7 weeks to 25 6/7 weeks of gestation. When delivery is anticipated near the limit of viability, families and health care teams are faced with complex and ethically challenging decisions. Multiple factors have been found to be associated with short-term and long-term outcomes of... ...
more infohttps://www.acog.org/Clinical-Guidance-and-Publications/Obstetric-Care-Consensus-Series?DateRange=lastsixmonths

Climate Change Consensus Is Virtually Unanimous | HuffPostClimate Change Consensus Is Virtually Unanimous | HuffPost

But what kind of consensus would you find if you skipped reading thoroughly vetted research papers and just walked up to ... You are free to disagree with my characterization of the consensus as "virtually unanimous," if you feel 99.83 percent doesnt ... and found that none disagreed with the consensus about man-made climate change. ...
more infohttps://www.huffingtonpost.com/neil-wagner/climate-change-consensus-_b_2273715.html

Brazils WTO candidate to focus on consensusBrazil's WTO candidate to focus on consensus

Speaking at a news conference in the capital, Brasilia, Roberto Azevedo said hed strive to build consensus between developed ... without imposing views on anyone and trying to forge all possible consensuses." ... nudge opposing sides into sitting down together and said that he personally has demonstrated a similar capacity for consensus ...
more infohttps://www.yahoo.com/news/brazils-wto-candidate-focus-consensus-174501556.html?ref=gs

A Healthy Bladder: A Consensus StatementA Healthy Bladder: A Consensus Statement

... and behavioral therapy present a consensus statement on the importance of maintaining bladder health. ... For BPS/IC in particular, there remains a lack of consensus on diagnosis based on the lack of a diagnostic instrument to ... Potential Benefits of the Consensus Statement on Bladder Health. This statement is intended to raise awareness of bladder ... An anticipated benefit from this consensus statement is to raise awareness among the Public Health world regarding bladder ...
more infohttps://www.medscape.com/viewarticle/750519_3

GNU consensus - GNU Project - Free Software FoundationGNU consensus - GNU Project - Free Software Foundation

The GNU consensus community gathers on the Freenode IRC channel #consensus. GNU consensus Wiki. Work in progress is available ... The GNU consensus may produce software: when it does, it is free software; you can redistribute it and/or modify it under the ... Due to the nature and youth of the project, we currently provide a unique list ,consensus@gnu.org,. As the project evolves, ... GNU consensus is currently being maintained by hellekin. Please use the mailing lists for contact.. Licensing. ...
more infohttp://www.gnu.org/consensus/

Consensus on preventing osteoporosis. | The BMJConsensus on preventing osteoporosis. | The BMJ

Consensus on preventing osteoporosis. Br Med J (Clin Res Ed) 1987; 295 :872 ... Consensus on preventing osteoporosis.. Br Med J (Clin Res Ed) 1987; 295 doi: https://doi.org/10.1136/bmj.295.6603.872 ( ...
more infohttp://www.bmj.com/content/295/6603/872

Consensus-Based Privacy-Preserving Algorithm | SpringerLinkConsensus-Based Privacy-Preserving Algorithm | SpringerLink

Based on consensus-based distributed support vector machines, we present a new consensus-based privacy-preserving algorithm to ... Based on consensus-based distributed support vector machines, we present a new consensus-based privacy-preserving algorithm to ... Li H., Xu F. (2019) Consensus-Based Privacy-Preserving Algorithm. In: Liang Q., Mu J., Jia M., Wang W., Feng X., Zhang B. (eds ... Forero, P.A., Cano, A., Giannakis, G.B.: Consensus-based distributed support vector machines. J. Mach. Learn. Res. 11, 1663- ...
more infohttps://link.springer.com/chapter/10.1007%2F978-981-10-6571-2_203

Protein consensus sequence motifs | SpringerLinkProtein consensus sequence motifs | SpringerLink

The large number of protein consensus sequences that may be recognized without computer analysis are reviewed. These include ... The large number of protein consensus sequences that may be recognized without computer analysis are reviewed. These include ... Aitken, A. (1995) Protein chemistry methods, posttranslational modification, consensus sequences, in Proteins Labfax (Price, N ... and consensus sequences that may be carried out on the internet. ... Protein consensus sequences motifs protein-protein interaction ...
more infohttps://link.springer.com/article/10.1385%2FMB%3A12%3A3%3A241

Consensus | The Cohousing AssociationConsensus | The Cohousing Association

Consensus Below is all of the content on our site that has been tagged Consensus. Dont see what youre looking for? Try:. * ...
more infohttp://www.cohousing.org/taxonomy/term/55?page=1

Tol quote on consensusTol quote on consensus

... Quote from Tol (2014):. "There is no doubt in my mind that the literature on climate change ... I have very little reason to doubt that the consensus is indeed correct." ...
more infohttps://skepticalscience.com/graphics.php?g=111

MCPS TAH: Conflict and ConsensusMCPS TAH: Conflict and Consensus

Teaching American History: Conflict and Consensus: Key Moments in U.S. History. ...
more infohttp://chnm.gmu.edu/mcpstah/
  • A smaller meta-study, conducted by Naomi Oreskes in 2005, reviewed 985 papers published between 1993 and 2003, and found that none disagreed with the consensus about man-made climate change. (huffingtonpost.com)
  • A Summary of the Wang-Koo Talks published by the SEF in August 1993 stated that the consensus reached by ARATS and SEF were quite clear: both sides had worked hard to seek common points while reserving differences in explaining the political content of one China. (chinadaily.com.cn)
  • Consensus estimate is a technique for designing truthful mechanisms in a prior-free mechanism design setting. (wikipedia.org)
  • As a first attempt of a consensus-estimate, let R a p p = ⌊ R m a x ⌋ {\displaystyle R_{app}=\lfloor R_{max}\rfloor } = the value of R m a x {\displaystyle R_{max}} rounded to the nearest integer below it. (wikipedia.org)
  • Such random variable R a p p {\displaystyle R_{app}} is called a consensus estimate: "Consensus" means that, with high probability, a single agent cannot influence the outcome, so that there is an agreement between the outcomes with or without the agent. (wikipedia.org)
  • The disadvantages of using a consensus estimate are: It does not give us the optimal profit - but it gives us an approximately-optimal profit. (wikipedia.org)
  • In the case of digital goods, using this consensus-estimate allows us to attain at least 1/3.39 of the optimal profit, even in worst-case scenarios. (wikipedia.org)
  • The large number of protein consensus sequences that may be recognized without computer analysis are reviewed. (springer.com)
  • This article includes an introduction to accessing the many suites of programs for analysis of protein structure, signatures of protein families, and consensus sequences that may be carried out on the internet. (springer.com)
  • A good reference for discrete time consensus algorithms and theoretical explanation for consensus of multi-agent systems using nearest neighbor rules. (caltech.edu)
  • Consensus seeking in multi-agent systems under dynamically changing interaction topologies , W. Ren and R. W. Beard, IEEE Transactions on Automatic Control, vol. 50, issue 5, 655-661, May 2005. (caltech.edu)
  • A major topic of investigation is the agreement or consensus problem in multi-agent systems that concerns processes by which a collection of interacting agents achieve a common goal. (wikipedia.org)
  • the goal is to reach consensus through critical discussion. (readwritethink.org)
  • From Oct. 28 to 30, 1992, the ARATS and SEF held negotiations over the use of notarized documents across the Strait in Hong Kong,and each side proposed five definitions about the ways to express the issue of adherence to the "one-China" principle, but failed to reach a consensus. (chinadaily.com.cn)
  • Networks of agents that exchange information to reach consensus include: physiological systems, gene networks, large-scale energy systems and fleets of vehicles on land, in the air or in space. (wikipedia.org)
  • So where did that famous "consensus" claim that "98% of all scientists believe in global warming" come from? (forbes.com)
  • But what kind of consensus would you find if you skipped reading thoroughly vetted research papers and just walked up to members of the climate science community to ask them their convictions? (huffingtonpost.com)
  • Consensus dynamics or agreement dynamics is an area of research lying at the intersection of systems theory and graph theory. (wikipedia.org)
  • Calvinism portal The Helvetic Consensus (Latin: Formula consensus ecclesiarum Helveticarum) is a Swiss Reformed symbol drawn up in 1675 to guard against doctrines taught at the French Academy of Saumur, especially Amyraldism. (wikipedia.org)
  • This 2012 Consensus paper reviews the literature on side effects of x-ray exposure in the pediatric population as it relates to scoliosis evaluation and treatment. (biomedcentral.com)
  • This report is the SOSORT Consensus Paper on Terminology for use in the treatment of conservative spinal deformities. (biomedcentral.com)
  • Recorded for Medscape France at the European Society of Cardiology meeting in London, United Kingdom, the following is a translation of a commentary by Dr Alexandre Mebazaa, lead author of a consensus paper from the Heart Failure Association of the European Society of Cardiology, the European Society for Emergency Medicine, and the Society for Academic Emergency Medicine on the management of acute heart failure. (medscape.com)
  • Consensus statements are published in American Diabetes Association journals and other scientific/medical journals, as appropriate. (diabetesjournals.org)
  • The "1992 Consensus", on the "one-China" principle and its respective verbal wording of both sides, was reached in a meeting in November 1992 held in Hong Kong by the Association for Relations Across Taiwan Straits (ARATS) of the mainland, headed by Wang Daohan, and the Straits Exchange Foundation (SEF) of Taiwan, led by Koo Chen-fu. (chinadaily.com.cn)
  • That Scientific Global Warming Consensus. (forbes.com)
  • Scoliosis and Spinal Disorders , the official publication of the Society on Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT), has published several key consensus & guidelines articles from society meetings and workshops over the years. (biomedcentral.com)
  • The consensus in society is that fucking children is bad, yet the sentient garbage fire that is Milo Yiannopoulos professed his belief that old men having sex with 13-year-old girls was a goddamn great thing. (thethinkingatheist.com)
  • In 1649, Alexander Morus, the successor of Spanheim, but suspected of belonging to the liberal party, was compelled by the magistrates of Geneva to subscribe to a series of articles in the form of theses and antitheses, the first germ of the Formula consensus. (wikipedia.org)
  • I was ridiculed elsewhere on this forum for saying that I don't care what the consensus says. (thethinkingatheist.com)
  • The only consensus to be found here is that of those people who have held a conversation with you that cared enough to rep you didn't like you very much. (thethinkingatheist.com)
  • He referred to a "calculated campaign of disinformation", which he said "…has steadily beaten back the consensus momentum [italics added] for action on climate change and replaced it with timidity proponents in the face of millions of dollars of phony, contrived 'talking points', illogical and wholly unscientific propositions, and a general scorn for the truth wrapped in false threats about job loss and tax increase. (forbes.com)
  • Therefore, it's fundamental that the future director general be able to move easily among the different groups of countries, regardless of their level of development, without imposing views on anyone and trying to forge all possible consensuses. (yahoo.com)
  • Development of GNU consensus , and GNU in general, is a volunteer effort, and you can contribute. (gnu.org)
  • The GNU consensus recommends participant projects to provide their source code under either the GNU Affero General Public License , or the GNU General Public License , either version 3 of each license, or (at your option) any later version. (gnu.org)
  • Trying to equate the "consensus" (10 people on the internet constitutes a consensus now apparently) that you're a cunt to those that supported slavery is vulgar and just bloody stupid. (thethinkingatheist.com)
  • You are free to disagree with my characterization of the consensus as "virtually unanimous," if you feel 99.83 percent doesn't qualify. (huffingtonpost.com)