General agreement or collective opinion; the judgment arrived at by most of those concerned.
A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.
Presentations of summary statements representing the majority agreement of physicians, scientists, and other professionals convening for the purpose of reaching a consensus--often with findings and recommendations--on a subject of interest. The Conference, consisting of participants representing the scientific and lay viewpoints, is a significant means of evaluating current medical thought and reflects the latest advances in research for the respective field being addressed.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
An iterative questionnaire designed to measure consensus among individual responses. In the classic Delphi approach, there is no interaction between responder and interviewer.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Articles on conferences sponsored by NIH presenting summary statements representing the majority agreement of physicians, scientists, and other professionals convening for the purpose of reaching a consensus on a subject of interest. This heading is used for NIH consensus conferences as a means of scientific communication. In indexing it is viewed as a type of review article and as a tag for any article appearing in any publication of the NIH Office of Medical Applications of Research (OMAR).
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Societies whose membership is limited to physicians.
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
Nucleic acid sequences involved in regulating the expression of genes.
Established cell cultures that have the potential to propagate indefinitely.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes.
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
Proteins found in any species of bacterium.
Presentation of pertinent data by one with special skill or knowledge representing mastery of a particular subject.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
The relationships of groups of organisms as reflected by their genetic makeup.
Proteins prepared by recombinant DNA technology.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
The functional hereditary units of BACTERIA.
A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.
Any method used for determining the location of and relative distances between genes on a chromosome.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Deletion of sequences of nucleic acids from the genetic material of an individual.
Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
Sequential operating programs and data which instruct the functioning of a digital computer.
The ultimate exclusion of nonsense sequences or intervening sequences (introns) before the final RNA transcript is sent to the cytoplasm.
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression. IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence.
A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Biochemical identification of mutational changes in a nucleotide sequence.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Transport proteins that carry specific substances in the blood or across cell membranes.
The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.
Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.
An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Deoxyribonucleic acid that makes up the genetic material of viruses.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Elements of limited time intervals, contributing to particular results or situations.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information.
The rate dynamics in chemical or physical systems.
Deoxyribonucleic acid that makes up the genetic material of fungi.
The quality or state of relating to or affecting two or more nations. (After Merriam-Webster Collegiate Dictionary, 10th ed)
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)
A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.
A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Recommendations for directing health planning functions and policies. These may be mandated by PL93-641 and issued by the Department of Health and Human Services for use by state and local planning agencies.
Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
A conserved A-T rich sequence which is contained in promoters for RNA polymerase II. The segment is seven base pairs long and the nucleotides most commonly found are TATAAAA.
A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
Genotypic differences observed among individuals in a population.
A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
The field which deals with illustrative clarification of biomedical concepts, as in the use of diagrams and drawings. The illustration may be produced by hand, photography, computer, or other electronic or mechanical methods.
A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.
A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
The functional hereditary units of FUNGI.
Proteins found in any species of fungus.
A form of GENE LIBRARY containing the complete DNA sequences present in the genome of a given organism. It contrasts with a cDNA library which contains only sequences utilized in protein coding (lacking introns).
Proteins found in any species of virus.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Two-dimensional separation and analysis of nucleotides.
Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
A sequential pattern of amino acids occurring more than once in the same protein sequence.
A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
The administration of nutrients for assimilation and utilization by a patient by means other than normal eating. It does not include FLUID THERAPY which normalizes body fluids to restore WATER-ELECTROLYTE BALANCE.
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
The first nucleotide of a transcribed DNA sequence where RNA polymerase (DNA-DIRECTED RNA POLYMERASE) begins synthesizing the RNA transcript.
Nucleotide sequences located at the ends of EXONS and recognized in pre-messenger RNA by SPLICEOSOMES. They are joined during the RNA SPLICING reaction, forming the junctions between exons.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.
Proteins obtained from ESCHERICHIA COLI.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
RNA transcripts of the DNA that are in some unfinished stage of post-transcriptional processing (RNA PROCESSING, POST-TRANSCRIPTIONAL) required for function. RNA precursors may undergo several steps of RNA SPLICING during which the phosphodiester bonds at exon-intron boundaries are cleaved and the introns are excised. Consequently a new bond is formed between the ends of the exons. Resulting mature RNAs can then be used; for example, mature mRNA (RNA, MESSENGER) is used as a template for protein production.
The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.
A broad approach to appropriate coordination of the entire disease treatment process that often involves shifting away from more expensive inpatient and acute care to areas such as preventive medicine, patient counseling and education, and outpatient care. This concept includes implications of appropriate versus inappropriate therapy on the overall cost and clinical outcome of a particular disease. (From Hosp Pharm 1995 Jul;30(7):596)
The sequence at the 5' end of the messenger RNA that does not code for product. This sequence contains the ribosome binding site and other transcription and translation regulating sequences.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
Patterns of practice related to diagnosis and treatment as especially influenced by cost of the service requested and provided.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.
In eukaryotes, a genetic unit consisting of a noncontiguous group of genes under the control of a single regulator gene. In bacteria, regulons are global regulatory systems involved in the interplay of pleiotropic regulatory domains and consist of several OPERONS.
Ribonucleic acid that makes up the genetic material of viruses.
Conformity in fulfilling or following official, recognized, or institutional requirements, guidelines, recommendations, protocols, pathways, or other standards.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.
Activities and programs intended to assure or improve the quality of care in either a defined medical setting or a program. The concept includes the assessment or evaluation of the quality of care; identification of problems or shortcomings in the delivery of care; designing activities to overcome these deficiencies; and follow-up monitoring to ensure effectiveness of corrective steps.
Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.
Published materials which provide an examination of recent or current literature. Review articles can cover a wide range of subject matter at various levels of completeness and comprehensiveness based on analyses of literature that may include research findings. The review may reflect the state of the art. It also includes reviews as a literary form.
A protein which is a subunit of RNA polymerase. It effects initiation of specific RNA chains from DNA.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.

Ethical considerations in international HIV vaccine trials: summary of a consultative process conducted by the Joint United Nations Programme on HIV/AIDS (UNAIDS). (1/739)

Research that is initiated, designed or funded by sponsor agencies based in countries with relatively high social and economic development, and conducted in countries that are relatively less developed, gives rise to many important ethical challenges. Although clinical trials of HIV vaccines began ten years ago in the US and Europe, an increasing number of trials are now being conducted or planned in other countries, including several that are considered "developing" countries. Safeguarding the rights and welfare of individuals participating as research subjects in developing countries is a priority. In September, 1997, the Joint United Nations Programme on HIV/AIDS (UNAIDS) embarked on a process of international consultation; its purpose was further to define the important ethical issues and to formulate guidance that might facilitate the ethical design and conduct of HIV vaccine trials in international contexts. This paper summarises the major outcomes of the UNAIDS consultative process.  (+info)

Clinical ethics committees and the formulation of health care policy. (2/739)

For some time, clinical ethics committees (CECs) have been a prominent feature of hospitals in North America. Such committees are less common in the United Kingdom and Europe. Focusing on the UK, this paper evaluates why CECs have taken so long to evolve and assesses the roles that they should play in health care policy and clinical decision making. Substantive and procedural moral issues in medicine are differentiated, the former concerning ethicolegal principles and their paradigmatic application to clinical practice and the latter dealing with how such application should be negotiated in the face of disagreement and/or uncertainty. It will be argued that the role of CECs is both substantive and procedural. Provided that they do not overstep their appropriate moral and professional boundaries, CECs will be shown to have an important and positive function in improving hospital care within the UK and elsewhere.  (+info)

Quality and methods of developing practice guidelines. (3/739)

BACKGROUND: It is not known whether there are differences in the quality and recommendations between evidence-based (EB) and consensus-based (CB) guidelines. We used breast cancer guidelines as a case study to assess for these differences. METHODS: Five different instruments to evaluate the quality of guidelines were identified by a literature search. We also searched MEDLINE and the Internet to locate 8 breast cancer guidelines. These guidelines were classified in three categories: evidence based, consensus based and consensus based with no explicit consideration of evidence (CB-EB). Each guideline was evaluated by three of the authors using each of the instruments. For each guideline we assessed the agreement among 14 decision points which were selected from the NCCN (National Cancer Comprehensive Network) guidelines algorithm. For each decision point we recorded the level of the quality of the information used to support it. A regression analysis was performed to assess if the percentage of high quality evidence used in the guidelines development was related to the overall quality of the guidelines. RESULTS: Three guidelines were classified as EB, three as CB-EB and two as CB. The EB guidelines scored better than CB, with the CB-EB scoring in the middle among all instruments for guidelines quality assessment. No major disagreement in recommendations was detected among the guidelines regardless of the method used for development, but the EB guidelines had a better agreement with the benchmark guideline for any decision point. When the source of evidence used to support decision were of high quality, we found a higher level of full agreement among the guidelines' recommendations. Up to 94% of variation in the quality score among guidelines could be explained by the quality of evidence used for guidelines development. CONCLUSION: EB guidelines have a better quality than CB guidelines and CB-EB guidelines. Explicit use of high quality evidence can lead to a better agreement among recommendations. However, no major disagreement among guidelines was noted regardless of the method for their development.  (+info)

Inter-rater agreement in the scoring of abstracts submitted to a primary care research conference. (4/739)

BACKGROUND: Checklists for peer review aim to guide referees when assessing the quality of papers, but little evidence exists on the extent to which referees agree when evaluating the same paper. The aim of this study was to investigate agreement on dimensions of a checklist between two referees when evaluating abstracts submitted for a primary care conference. METHODS: Anonymised abstracts were scored using a structured assessment comprising seven categories. Between one (poor) and four (excellent) marks were awarded for each category, giving a maximum possible score of 28 marks. Every abstract was assessed independently by two referees and agreement measured using intraclass correlation coefficients. Mean total scores of abstracts accepted and rejected for the meeting were compared using an unpaired t test. RESULTS: Of 52 abstracts, agreement between reviewers was greater for three components relating to study design (adjusted intraclass correlation coefficients 0.40 to 0.45) compared to four components relating to more subjective elements such as the importance of the study and likelihood of provoking discussion (0.01 to 0.25). Mean score for accepted abstracts was significantly greater than those that were rejected (17.4 versus 14.6, 95% CI for difference 1.3 to 4.1, p = 0.0003). CONCLUSIONS: The findings suggest that inclusion of subjective components in a review checklist may result in greater disagreement between reviewers. However in terms of overall quality scores, abstracts accepted for the meeting were rated significantly higher than those that were rejected.  (+info)

Priority setting for new technologies in medicine: a transdisciplinary study. (5/739)

BACKGROUND: Decision makers in health care organizations struggle with how to set priorities for new technologies in medicine. Traditional approaches to priority setting for new technologies in medicine are insufficient and there is no widely accepted model that can guide decision makers. DISCUSSION: Daniels and Sabin have developed an ethically based account about how priority setting decisions should be made. We have developed an empirically based account of how priority setting decisions are made. In this paper, we integrate these two accounts into a transdisciplinary model of priority setting for new technologies in medicine that is both ethically and empirically based. SUMMARY: We have developed a transdisciplinary model of priority setting that provides guidance to decision makers that they can operationalize to help address priority setting problems in their institution.  (+info)

Consensus guidelines on analgesia and sedation in dying intensive care unit patients. (6/739)

BACKGROUND: Intensivists must provide enough analgesia and sedation to ensure dying patients receive good palliative care. However, if it is perceived that too much is given, they risk prosecution for committing euthanasia. The goal of this study is to develop consensus guidelines on analgesia and sedation in dying intensive care unit patients that help distinguish palliative care from euthanasia. METHODS: Using the Delphi technique, panelists rated levels of agreement with statements describing how analgesics and sedatives should be given to dying ICU patients and how palliative care should be distinguished from euthanasia. Participants were drawn from 3 panels: 1) Canadian Academic Adult Intensive Care Fellowship program directors and Intensive Care division chiefs (N = 9); 2) Deputy chief provincial coroners (N = 5); 3) Validation panel of Intensivists attending the Canadian Critical Care Trials Group meeting (N = 12). RESULTS: After three Delphi rounds, consensus was achieved on 16 statements encompassing the role of palliative care in the intensive care unit, the management of pain and suffering, current areas of controversy, and ways of improving palliative care in the ICU. CONCLUSION: Consensus guidelines were developed to guide the administration of analgesics and sedatives to dying ICU patients and to help distinguish palliative care from euthanasia.  (+info)

Development of the Knee Standardized Clinical Interview: a research tool for studying the primary care clinical epidemiology of knee problems in older adults. (7/739)

OBJECTIVE: To develop a standardized clinical interview, incorporating the perspectives of general practitioners (GPs) and rheumatologists, for primary care clinical epidemiological studies of adults aged 50 yr and over with knee problems. METHODS: Two parallel, consensus development studies using a modified nominal group technique involving GPs (n=5) and consultant rheumatologists (n=4) from North Staffordshire with reference panels of GPs (n=28) and rheumatologists (n=11) from selected centres in Great Britain, respectively. A single standardized clinical interview was formed using the clinical history questions identified in the consensus development studies and its feasibility was tested in a small sample of patients. RESULTS: In the GP consensus development study, 115 clinical history questions were identified, of which 71 were of agreed importance following postal rating, face-to-face discussion and re-rating. In the rheumatologist study, 158 questions were identified, of which 47 were of agreed importance. There was considerable overlap in the clinical history questions independently developed by the two studies. A single standardized clinical interview containing 74 questions was formed. It contained questions on the history, onset and recent course of the complaint; nature, location and severity of current knee symptoms; impact of knee problem; past history of knee problems; family history; comorbidity; previous/current investigations and treatment; ideas, concerns and expectations. In preliminary testing it took 20-45 min to conduct and was comprehensible to patients. CONCLUSIONS: A research tool-the Knee Standardized Clinical Interview (KNE-SCI)-has been formed from consensus development studies involving GPs and rheumatologists. In preliminary testing, it is comprehensible to patients, and forms a coherent clinical interview for research data collection. However, further evaluation is required to determine its accuracy and reliability and its usefulness for clinical epidemiological research.  (+info)

Building consensus on nomenclature and disease classification for ankylosing spondylitis: results and discussion of a questionnaire prepared for the International Workshop on New Treatment Strategies in Ankylosing Spondylitis, Berlin, Germany, 18-19 January 2002. (8/739)

BACKGROUND: There is currently no universal consensus on nomenclature for spondyloarthropathy (SpA), or on activity and severity criteria for ankylosing spondylitis (AS). METHOD: Points of agreement and majority opinions among 28 international experts in the field were identified by questionnaire. Agreement was defined as >80% concurrence, clear majority as >60% concurrence, and a majority or trend as >50% concurrence. RESULTS: Respondents agreed on the need for one term that reflects the inflammatory nature of the disease, but no agreement was reached on a specific term. Agreement included subdivision of patients with SpA into AS, psoriatic arthritis, inflammatory bowel disease associated arthritis, and undifferentiated spondyloarthritis/spondyloarthropathy. A majority of experts defined active disease as fulfilling classification criteria for AS and/or a SpA, and disease activity measured by a Bath AS Disease Activity Index (BASDAI) score >4 determined by two patient visits during a two month period, but no maximum radiographic score. The majority of participants considered failure of treatment response to non-steroidal anti-inflammatory drugs (NSAIDs) alone to be a prerequisite for active/severe AS, and 15/28 (54%) thought that NSAID treatment failure should be defined as lack of response to two or more NSAIDs. CONCLUSIONS: Respondents agreed that a two to five year study is the ethical method to demonstrate effects of anti-tumour necrosis factor alpha (TNFalpha) therapy on radiographic progression of AS, and that inclusion criteria should include a certain level of disease activity (measured by BASDAI) and failure of certain treatments. After the efficacy of anti-TNFalpha therapy in AS and psoriatic arthritis is proved, respondents agreed that more studies will be needed to show efficacy for other SpA subsets.  (+info)

November 6, 2008 - Lantheus Medical Imaging Inc. welcomes the Consensus Statement on the Clinical Applications of Ultrasound Contrast released by the American Society of Echocardiography (ASE) published in the November issue of the Journal of the American Society of Echocardiography.. Developed by members of the U.S. echocardiography community, ASEs consensus statement outlines when and how ultrasound contrast agents are to be used appropriately and efficiently to enhance the diagnostic capability of echocardiography.. We applaud the American Society of Echocardiography for its leadership in addressing the effective use of contrast ultrasound by authoring the Contrast Consensus Statement guidance document for the echocardiography community. This important consensus statement speaks to the clinical relevance of contrast and guides clinicians towards a team-approach to care for effective contrast use, said Don Kiepert, president and CEO, Lantheus Medical Imaging. The release of this ...
Lopez-Olivo, M. A., Kallen, M. A., Ortiz, Z., Skidmore, B. and Suarez-Almazor, M. E. (2008), Quality appraisal of clinical practice guidelines and consensus statements on the use of biologic agents in rheumatoid arthritis: A systematic review. Arthritis & Rheumatism, 59: 1625-1638. doi: 10.1002/art.24207 ...
Validation of non-invasive central blood pressure devices: ARTERY Society task force consensus statement on protocol standardization
AbstractThe burden of peripheral artery disease (PAD) and diabetes in Asia is projected to increase. Asia also has the highest incidence and prevalence of end-stage renal disease (ESRD) in the world. Therefore, most Asian patients with PAD might have diabetic PAD or ESRD-related PAD. Given these pandemic conditions, critical limb ischemia (CLI) with diabetes or ESRD, the most advanced and challenging subset of PAD, is an emerging public health issue in Asian countries. Given that diabetic and ESRD-related CLI have complex pathophysiology that involve arterial insufficiency, bacterial infection, neuropathy, and foot deformity, a coordinated approach that involves endovascular therapy and wound care is vital. Recently, there is increasing interaction among cardiologists, vascular surgeons, radiologists, orthopedic surgeons, and plastic surgeons beyond specialty and country boundaries in Asia. This article is intended to share practical Asian multidisciplinary consensus statement on the ...
TY - JOUR. T1 - Conclusions. T2 - A consensus statement on growth hormone therapy. AU - Rosenfeld, R.. AU - Hochberg, Z.. AU - Albertsson-Wikland, K.. AU - Gluckman, P. D.. AU - Kastrup, K.. AU - Kauli, R.. AU - Pescovitz, O. H.. AU - Price, D. A.. AU - Ranke, M. B.. AU - Rappaport, R.. AU - Reiter, E. O.. AU - Saenger, P.. AU - Vanderschueren-Lodeweyckx, M.. AU - Van-Wyk, J. J.. AU - Werther, G. A.. AU - Zadik, Z.. AU - Zachmann, M.. PY - 1990/1/1. Y1 - 1990/1/1. UR - UR - M3 - Article. C2 - 2220383. AN - SCOPUS:0025298296. VL - 79. SP - 177. EP - 178. JO - Acta Paediatrica Scandinavica, Supplement. JF - Acta Paediatrica Scandinavica, Supplement. SN - 0300-8843. IS - 367. ER - ...
Despite numerous guidelines on the management of anaemia in surgical patients, there is no pragmatic guidance for the diagnosis and management of anaemia and iron deficiency in the postoperative period. A number of experienced researchers and clinicians took part in a two-day expert workshop and developed the following consensus statement. After presentation of our own research data and local policies and procedures, appropriate relevant literature was reviewed and discussed. We developed a series of best-practice and evidence-based statements to advise on patient care with respect to anaemia and iron deficiency in the postoperative period. These statements include: a diagnostic approach to iron deficiency and anaemia in surgical patients; identification of patients appropriate for treatment; and advice on practical management and follow-up that is easy to implement. Available data allow the fulfilment of the requirements of Pillar 1 of Patient Blood Management. We urge national and ...
The two- and one-half-day conference brought together experts in the field of relevant medical research and health care as well as representatives from the public. After listening to presentations and audience discussion at the conference, the panel, chaired by David J. Kupfer, M.D., Western Psychiatric Institute and Clinic, University of Pittsburgh, Pa., developed the statement.. The consensus statement can be found on the NIH Web site at The document can also be obtained from the NIH Consensus Program Information Center, P.O. Box 2577, Kensington, MD 20891; telephone: 888-644-2667.. ADHD is noted in the report to be the most commonly diagnosed behavioral disorder in childhood and represents a major public health problem. It is estimated that it affects 3 to 5 percent of all school-age children.. The report emphasizes that the impact of ADHD on the individuals with this disorder, their families and society is great. Children with ADHD cannot sit still and pay ...
This is a page with useful consensus documents and standards for people interested in clinical flow cytometry. The standards are listed in alphabetical order . If we are missing something, please feel free to contribute by adding it here. 2006 Bethesda International Consensus Recommendations on Immunophenotypic Analysis of Hematolymphoid Neoplasia by Flow Cytometry. Cytometry Part B, 2007. 2006 Bethesda International Consensus Recommendations on the Immunophenotypic Analysis of Hematolymphoid Neoplasia by Flow Cytometry: Recommendations for Training and Education to Perform Clinical Flow Cytometry, Cytometry Part B 2007 Clinical Flow Cytometric Analysis of Hematolymphoid Cells; Approved Guideline - Second Edition H43-A2 Clinical and Laboratory Standards Institute (CLSI) 2007 Enumeration of Immunologically Defined Cell Populations by Flow Cytometry; Approved Guideline-Second Edition H42-A2 Clinical and Laboratory Standards Institute (CLSI) 2007. MMWR 2003: Guidelines for Performing ...
A study contrasting the CDC Fukuda case definition with the International Consensus Criteria (ICC) for ME finds the ICC selects for a more physicall
A consensus statement is a comprehensive analysis by a panel of experts (i.e., consensus panel) of a scientific or medical issue related to diabetes. A consensus statement is developed immediately after a consensus conference at which presentations are made on the issue under review. The statement represents the panels collective analysis, evaluation, and opinion based, in part, on the conference proceedings. The need for a consensus statement arises when clinicians or scientists desire guidance on a subject for which there is a relative deficiency of comprehensive evidence that might otherwise allow for a more definitive statement to be made.. Consensus statements are published in American Diabetes Association journals and other scientific/medical journals, as appropriate. Once written by the panel, a consensus statement is not subject to subsequent review or approval and does not represent official association opinion. Listed below are recent consensus statements.. Postprandial Blood Glucose ...
An international consensus document on acellular matrix products in the treatment of hard-to-heal wounds such as diabetic foot ulcers, venous leg ulcers and pressure ulcers. Currently there is no definitive paper or guideline on the use of acellular matrices in acute and chronic wounds. To.... ...
Objectives: The aim of the present publication was to report on the EAO Workshop group-4 discussions and consensus statements on the five reviews previously prepared. These reviews provided the scientific evidence on the effect of crown-to-implant ratio, on reconstructions with cantilevers in fully and partially edentulous patients, on biological and technical complications of tilted in comparison with straight implants, and on the effects of osseointegrated implants functioning in a residual dentition. Material and Methods: The group discussed, evaluated, corrected where deemed appropriate, and made recommendations to the authors regarding the following five reviews submitted: (a) Is there an effect of crown-to-implant ratio on implant treatment outcomes?; (b) Implant-supported cantilevered fixed dental rehabilitations in fully edentulous patients; (c) and in partially edentulous patients; (d) Biological and technical complications of tilted implants in comparison with straight implants ...
The National Consensus Statement: Essential elements for safe and high-quality end-of-life care (the Consensus Statement) was endorsed by Australian Health Ministers in May 2015.. Clinicians, health service executives and managers, policy-makers, educators and training providers can use the principles and ten essential elements of the Consensus Statement as a guide to improving the safety and quality of end-of-life care.. The consensus statement was developed in partnership with health consumers and carers, experts in the field, representatives from public and private hospitals and health services, professional colleges, state and territory health departments, and other government health agencies. Please contact the Commission if you would like more details on the consultation process.. Preliminary scoping work undertaken prior to developing the consensus statement is summarised in Safety and Quality of End-of-Life Care in Acute Hospitals: A Background Paper. This paper presents a précis of the ...
Though recently bolstered by the results of the PIONEER AF-PCI trial, the evidence base on how to manage antithrombotic therapy in patients with A-fib undergoing PCI remains limited and clinical uncertainty abounds. Now, an updated North American consensus document aims to provide some guidance to clinicians wondering what to do with this hard-to-treat population.. Since the last iteration of the document was published in 2011, new evidence regarding the management of antiplatelet and anticoagulant therapies in patients requiring both has emerged in the form of the WOEST and ISAR-TRIPLE trials. PIONEER AF-PCI provides even more information but was released too recently-just 2 weeks ago at the American Heart Association Scientific Sessions-to be incorporated into the new consensus document, which was published online November 1, 2016, ahead of print in Circulation: Cardiovascular Interventions and discussed during a presentation at TCT 2016.. Clinicians have little to go on when deciding how to ...
Most functional test procedures are based on closed skill tasks (eg, single or triple hop, T drill, figure 8 runs), but sport requires open skills in addition to closed skills. Open skills have a reactive element to execute the motor task, usually in addition to decision-making, often in a fatigued state. Therefore, relying on closed skill tasks alone in determining readiness to RTS is not optimal. Gradual and sequential introduction of sport-specific training can be used as functional tests that include an element of protected reactive decision-making (ideally context specific).19-21 Any battery of tests assessing the athletes readiness to RTS should consider both open and closed skills, although in some clinical contexts this may be difficult because of factors including time, space and resources. If this is the case, assessment of closed skills in conjunction with other impairment-based and functional parameters gives the clinician and the athlete a minimum level of information for RTS ...
Lateral ankle sprains (LASs) are the most prevalent musculoskeletal injury in physically active populations. They also have a high prevalence in the general population and pose a substantial healthcare burden. The recurrence rates of LASs are high, leading to a large percentage of patients with LAS …
Paul Kidd from the HIV Legal Working Group (VAC and Positive Life VIC) launched a recently published consensus statement about HIV and the law at the ASHM hub during the afternoon break on Wednesday. The consensus statement was written by leading HIV
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For the present, TNF blockade should be reserved for patients with RA whose symptoms and signs are resistant to disease modifying antirheumatic drug (DMARD) treatment. It is generally agreed that all patients with active disease should be treated with DMARDs, as such treatment ameliorates symptoms and slows progression of structural damage.2 However, long term efficacy of DMARDs is limited and toxicity accumulates.3 Currently, two TNF-blocking agents, etanercept and infliximab, have received regulatory authority approval for the treatment of RA. Both compounds, alone or in combination with methotrexate, have proved to be successful in significantly reducing inflammatory activity and increasing the quality of life.4-8 In addition, infliximab in combination with methotrexate has been shown to arrest radiographic progression over one year in up to 50% of patients,9 while etanercept has been shown to retard radiographic progression significantly in DMARD-naive patients.10 Nevertheless, in early RA, ...
Future progress on understanding and treating infections caused by equine herpesvirus-1 will depend on research into viral pathogenesis
Thank you for your interest in spreading the word about Diabetes Care.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
The Team Physician Consensus Conference is a project-based alliance. The group meets annually to produce a consensus statement, which is a blend of evidence-based research and expert consensus.
This cohort study uses health system and research cohort data to compare the ability of existing vs new clinical criteria for sepsis to identify intensive care
There is no consensus on the pathologic conditions or severity implied by the term hippocampal sclerosis (HS). In this study, a panel of experienced neuropathologists evaluated inter-rater agreement for pathologic diagnoses in the hippocampus and proposes consensus recommendations on the use of the term HS. In a group of 251 cases of HS selected from a large autopsy cohort (1,388; 18%), a coordinating group identified 5 patterns of degenerative or vascular pathology. Four independent neuropathologists assessed a single set of hematoxylin and eosin-stained sections following descriptive definitions to classify the appearances and assign the diagnosis of HS, if appropriate. Diagnostic agreement (range, 36%-70%) was highest for vascular lesions. Subsequent joint review of all cases highlighted the need to identify neurodegenerative lesions using immunohistochemistry. Initial agreement in assigning the diagnosis of HS varied from 0% to 86%. After a joint review, the group recommended that the ...
A recent study suggests that while the ICC does select for more ME/CFS-like patients it also selects for patients with more psychiatric disorders.
The European Association for the Study of Diabetes (EASD) and the American Diabetes Association (ADA) have produced an updated consensus statement on
Stamatakis and colleagues from University College present comprehensive data about overweight and obesity trends from 1974 to 2003 in English children. The data are disturbing, but not surprising. They mimic information from many other countries. For example, the rates of obesity for boys aged 5-7 years increased from 1.0% in 1974 to 5.2% in 2002-03. For obesity, there was a five to six fold increase for all groups (boys and girls aged 5-7 and 8-10 years), and a near doubling in the prevalence of overweight children (18.5% to 27.1%). Sadly, the rate of change was substantially greater between 2000-01 and 2002-03 than between 1974 and 2000. In a companion perspective, Rudolf, Hochberg, and Speiser describe the conclusions of a recent International Consensus Statement on childhood obesity. The statement addresses definition, preventive strategies, screening, assessment, and treatment. The authors discuss the implications of this statement for the UK.. A recent brouhaha occurred in the US with ...
Leading Diabetes Organizations Issue Consensus Statement Defining Health Outcomes beyond HbA1c --The Type 1 Diabetes Outcomes Program, organized by JDRF, has identified and defined clinically meaningful
The link below is to the 2015 Consensus document about BCG and alternatives. Consensus statement on best practice management regarding the use of intravesical...
Orlandi RR, Kingdom TT, Hwang PH, Smith TL, Alt JA, Baroody FM, Batra PS, Bernal-Sprekelsen M, Bhattacharyya N, Chandra RK, Chiu A, Citardi MJ, Cohen NA, DelGaudio J, Desrosiers M, Dhong HJ, Douglas R, Ferguson B, Fokkens WJ, Georgalas C, Goldberg A, Gosepath J, Hamilos DL, Han JK, Harvey R, Hellings P, Hopkins C, Jankowski R, Javer AR, Kern R, Kountakis S, Kowalski ML, Lane A, Lanza DC, Lebowitz R, Lee HM, Lin SY, Lund V, Luong A, Mann W, Marple BF, McMains KC, Metson R, Naclerio R, Nayak JV, Otori N, Palmer JN, Parikh SR, Passali D, Peters A, Piccirillo J, Poetker DM, Psaltis AJ, Ramadan HH, Ramakrishnan VR, Riechelmann H, Roh HJ, Rudmik L, Sacks R, Schlosser RJ, Senior BA, Sindwani R, Stankiewicz JA, Stewart M, Tan BK, Toskala E, Voegels R, Wang de Y, Weitzel EK, Wise S, Woodworth BA, Wormald PJ, Wright ED, Zhou B, Kennedy DW. International Consensus Statement on Allergy and Rhinology: Rhinosinusitis. Int Forum Allergy Rhinol. 2016 Feb; 6 Suppl 1:S22-209. PMID: 26889651. ...
Management of anaemia and iron deficiency in patients with cancer • Management of infusion reactions to systemic anticancer therapy • Management of toxicities from immunotherapy • Management of febrile neutropaenia • MASCC and ESMO consensus guidelines for the prevention of chemotherapy and radiotherapy-induced nausea and vomiting • Treatment of dyspnoea in advanced cancer patients • Central venous access in oncology • Management of oral and gastrointestinal mucosal injury • Management of refractory symptoms at the end of life and the use of palliative sedation • Advanced care planning in palliative care • Bone health in cancer patients • Cancer, fertility and pregnancy • Management of chemotherapy extravasation • Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy • Management of cancer pain • Management of venous thromboembolism in cancer patients. ...
What should be the recommendations regarding the type (IV versus PO) and length of postoperative antibiotic treatment when a one-stage revision arthroplasty is performed for subacute/chronic shoulder PJI of the shoulder caused by an indolent organism (P. acnes, coag neg staph spec ...
What is the optimal management (Masquelet technique, bone transfer) of post-infective bone defects in different long bones (tibia, femur, humerus etc.)? How does this vary by type of defect (conical vs. cylindrical ...
Since the 2001 update of the American Heart Association (AHA)/American College of Cardiology (ACC) consensus statement on secondary prevention,1 important evidence from clinical trials has emerged that further supports and broadens the merits of aggressive risk-reduction therapies for patients with established coronary and other atherosclerotic vascular disease, including peripheral arterial disease, atherosclerotic aortic disease, and carotid artery disease. This growing body of evidence confirms that aggressive comprehensive risk factor management improves survival, reduces recurrent events and the need for interventional procedures, and improves quality of life for these patients.. Compelling evidence from recent clinical trials and revised practice guidelines provided the impetus for this update of the 2001 recommendations with evidence-based results (Table 1⇓). Classification of Recommendations and Level of Evidence are expressed in ACC/AHA format, as detailed in Tables 2 and 3⇓. ...
1996 - CDC, ACOG, and AAP publish the first consensus statement on GBS National Prevention Guidelines, June - GBSA publishes new patient education pamphlet based on new medical guidelines - Vaccine Officers prepare for first widespread clinical trials of GBS vaccine - GBSA expands National Medical Advisory Board to include researchers on adult GBS - GBSA has twelve State Medical Advisory Boards - GBSI (Group B Strep Initiative) Vaccine researchers enter last year of five year NIH (National Institutes of Health) grant - GBSA awarded $10,000 grant to work with CDC on GBS awareness among medical professionals working with at-risk African American women in inner city Atlanta ...
Nicole Artz, MD, a hospitalist and Assistant Professor of Medicine at the University of Chicago Hospital, discusses implications of hyperglycemia in hospitalized patients. References and Resources ACE/ADA Task Force on Inpatient Diabetes. American College of Endocrinology and American Diabetes Association Consensus statement on inpatient...
BACKGROUND AND OBJECTIVES: There are no widely accepted criteria for the definition of hematopoietic stem cell transplant -associated microangiopathy (TAM). An International Working Group was formed to develop a consensus formulation of criteria for diagnosing clinically significant TAM. DESIGN AND METHODS: The participants proposed a list of candidate criteria, selected those considered necessary, and ranked those considered optional to identify a core set of criteria. Three obligatory criteria and four optional criteria that ranked highest formed a core set. In an appropriateness panel process, the participants scored the diagnosis of 16 patient profiles as appropriate or not appropriate for TAM. Using the experts ratings on the patient profiles as a gold standard, the sensitivity and specificity of 24 candidate definitions of the disorder developed from the core set of criteria were evaluated. A nominal group technique was used to facilitate consensus formation. The definition of TAM with ...
I am not aware of any robust epidemiology studies investigating the possible effects of GBH exposures on endocrine-related diseases such as cancer, IQ loss, thyroid hormone perturbations, and organ changes. As stated in the international scientists consensus statement on glyphosate and its formulations, there are large gaps in our knowledge about such effects and more studies need to be carried out. Of course the absence of such published research is not a sign that GBHs do not cause endocrine effects. We have the technology and the scientists to do such work - but the latter apparently lack financial support and/or are worried about industry criticism and intimidation if the results show that GBHs should be banned.. ...
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The gTLD Registries Stakeholder Group (RySG) is a recognized entity within the Generic Names Supporting Organization (GNSO) formed according to Article X, Section 5 (September 009) of the Internet Corporation for Assigned Names and Numbers (ICANN) Bylaws.. The primary role of the RySG is to represent the interests of gTLD registry operators (or sponsors in the case of sponsored gTLDs) (Registries) (i) that are currently under contract with ICANN to provide gTLD registry services in support of one or more gTLDs; (ii) who agree to be bound by consensus policies in that contract; and (iii) who voluntarily choose to be members of the RySG. The RySG may include Interest Groups as defined by Article IV. The RySG represents the views of the RySG to the GNSO Council and the ICANN Board of Directors with particular emphasis on ICANN consensus policies that relate to interoperability, technical reliability and stable operation of the Internet or domain name system.. The guiding principles for the RySG, ...
Participants: In April 2004, a panel of physicians convened in New York City to discuss recommendations for clinical management of and additional research on SRI discontinuation syndrome. Evidence: Previous guidance for management of SRI discontinuation syndrome was proposed in 1997 in a consensus meeting also chaired by Alan F. Schatzberg. A literature search of the PubMed database was conducted to identify articles on SRI discontinuation syndrome that have been published since 1997 ...
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This text was prepared by the Task Force for the Safety of Novel Foods and Feeds to provide an introduction to the consensus documents of the OECDs Task Force. It explains, amongst other things, why the Task Force decided to prepare consensus documents as part of its programme of work. It describes their purpose and their use as a practical contribution to the risk/safety assessment of foods and feeds derived from transgenic. ...
List of publications by the Neuro-MIG network (COST Action CA16118) from 2017 to present:Biallelic DAB1 Variants Are Associated With Mild Lissencephaly and Cerebellar Hypoplasia. Daphne J. Smits, Rachel Schot, Martina Wilke, Marjon van Slegtenhorst, Marie Claire Y. de Wit, Marjolein H.G. Dremmen, William B. Dobyns, A. James Barkovich, Grazia M.S. Mancini. Neurology April 2021;
Lively debate ensued regarding the merits and otherwise of these techniques. The need to be innovative and to review what could be done better was a common theme. There was consensus that all clinical trials should also be testing the various biomarkers currently available. There was acute awareness that over the next five years there could well be a therapy available for some types of ALS/MND and it will be vital to ensure people have access as early as possible in the disease process. For some people with the familial form a reliable and objective biomarker could pick up disease progression before the person experiences any symptoms ...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
EDITORIAL International Angiology 2012 August;31(4):307-9. New oral anticoagulant in atrial fibrillation: are they comparable?. Kalodiki E., Lewis B., Fareed J.. PDF. ORIGINAL ARTICLES International Angiology 2012 August;31(4):310-5. Meta-analysis of the impact of the principal venoactive drugs agents on malleolar venous edema. Allaert F. A.. Abstract PDF. ORIGINAL ARTICLES International Angiology 2012 August;31(4):316-29. Chronic edema of the lower extremities: international consensus recommendations for compression therapy clinical research trials. Stout N., Partsch H., Szolnoky G., Forner-Cordero I., Mosti G., Mortimer P., Flour M., Damstra R., Piller N., Geyer M. J., Benigni J. P., Moffat C., Cornu-Thenard A., Schingale F., Clark M., Chauveau M.. Abstract PDF. ORIGINAL ARTICLES International Angiology 2012 August;31(4):330-9. Comparison of efficacy and safety of dabigatran, rivaroxaban and apixaban in patients with atrial fibrillation using network meta-analysis. Harenberg J., Marx S., ...
May 5, 2011 (Updated August 1, 2011) - Genetic testing is increasingly important in determining potential cardiac conditions in patients and is used in clinical settings more than ever before. To ensure that physicians have up-to-date knowledge of the evolving role of genetic testing for sudden death predisposing, genetic heart diseases in cardiology, which can be life-saving for some patients, the Heart Rhythm Society and the European Heart Rhythm Association have prepared HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies. The consensus statement was released at Heart Rhythm 2011, the Heart Rhythm Societys 32nd Annual Scientific Sessions.
We have read with interest the consensus document on the use of the polypill1 and the editorial by González-Juanatey et al.2 The authors should be congratulated for their initiative in producing a document that helps to increase our knowledge of this therapy and, moreover, defines the situations in which its use can be beneficial. The European Society of Cardiology indicates that reducing the frequency of administration is the most effective way to improve treatment adherence, and it reportedly could reduce cardiovascular events by 75%. However, in our opinion, this document does not deal with an aspect that we consider of vital importance in secondary prevention. Both the consensus document and the editorial underline the need to control hypertension and cholesterol, stressing high-risk patients, but make no mention of patients with coronary stents. We feel that they should include some comment on this subject, especially concerning drug-eluting stents, therapeutic devices used in most ...
Participants are required to be continually involved in answering a similar question in multiple rounds. The experts are allowed to adjust their answers in subsequent rounds, based on how they interpret the group response that has been provided to them. 3. : /ˈdɛlfaɪ/ del-fy) is a structured communication technique, originally developed as a systematic, interactive forecasting method which relies on a panel of experts. Delphi Technique: The name Delphi indicates a shrine at which the ancient Greeks used to pray for information about the future. 4. (iii) This technique eliminates the sense of motivation that arises in a face to face interacting group. Overview of the Delphi technique and some of its advantages and disadvantages. In the last 30 years, the application of the Delphi technique has been increasing. Recommended Articles. Several rounds of questionnaires are sent out to the group of experts, and the anonymous responses are aggregated and shared with the group after each round. You ...
TY - JOUR. T1 - ISHLT consensus statement on donor organ acceptability and management in pediatric heart transplantation. AU - Kirk, Richard. AU - Dipchand, Anne I.. AU - Davies, Ryan R.. AU - Miera, Oliver. AU - Chapman, Gretchen. AU - Conway, Jennifer. AU - Denfield, Susan. AU - Gossett, Jeffrey G.. AU - Johnson, Jonathan. AU - McCulloch, Michael. AU - Schweiger, Martin. AU - Zimpfer, Daniel. AU - Ablonczy, László. AU - Adachi, Iki. AU - Albert, Dimpna. AU - Alexander, Peta. AU - Amdani, Shahnawaz. AU - Amodeo, Antonio. AU - Azeka, Estela. AU - Ballweg, Jean. AU - Beasley, Gary. AU - Böhmer, Jens. AU - Butler, Alison. AU - Camino, Manuela. AU - Castro, Javier. AU - Chen, Sharon. AU - Chrisant, Maryanne. AU - Christen, Urs. AU - Danziger-Isakov, Lara. AU - Das, Bibhuti. AU - Everitt, Melanie. AU - Feingold, Brian. AU - Fenton, Matthew. AU - Garcia-Guereta, Luis. AU - Godown, Justin. AU - Gupta, Dipankar. AU - Irving, Claire. AU - Joong, Anna. AU - Kemna, Mariska. AU - Khulbey, Sanjeev ...
There is a need for a clear definition of exacerbations used in clinical trials in patients with bronchiectasis. An expert conference was convened to develop a consensus definition of an exacerbation for use in clinical research.. A systematic review of exacerbation definitions used in clinical trials from January 2000 until December 2015 and involving adults with bronchiectasis was conducted. A Delphi process followed by a round-table meeting involving bronchiectasis experts was organised to reach a consensus definition. These experts came from Europe (representing the European Multicentre Bronchiectasis Research Collaboration), North America (representing the US Bronchiectasis Research Registry/COPD Foundation), Australasia and South Africa.. The definition was unanimously approved by the working group as: a person with bronchiectasis with a deterioration in three or more of the following key symptoms for at least 48 h: cough; sputum volume and/or consistency; sputum purulence; breathlessness ...
In a review of research papers published in the period 1966 to 2005, Pluim et al1 showed that reported incidences of tennis injuries ranged over two orders of magnitude (0.04 to 3 injuries/1000 player-hours). Although some of this variation can be accounted for by the different sample populations used in the studies, the authors stated that the main reason for the differences was more likely to be due to the variation in injury definitions and protocols employed in the studies. Consensus statements for cricket,2 football3 and rugby union4 have previously outlined the benefits associated with developing and implementing consistent definitions, data-collection procedures and methods of reporting results in injury surveillance studies. Although these consensus statements were specifically developed for team sports, the International Olympic Committee (IOC) and the International Association of Athletics Federations (IAAF) demonstrated that the principles were also relevant to individual sports.5 6 ...
While many studies have reported that providing parenteral nutrition (PN) can change nutritional outcomes, there are limited data that demonstrate that PN influences clinically-important end points in critically-ill patients. The purpose of the present paper is to systematically review and critically appraise the literature to examine the relationship between PN and morbidity and mortality in the critically-ill patient. Studies comparing enteral nutrition (EN) with PN and studies comparing PN with no PN were reviewed. The results suggest that EN is associated with reduced infectious complications in some critically-ill subgroups. PN, on the other hand, is associated with increased morbidity and mortality in critically-ill patients. When nutritional support is indicated, EN should be used preferentially over PN. Further studies are needed to define the optimal timing and composition of PN in patients not tolerating sufficient EN. Strategies to optimize EN delivery and minimize PN utilization in ...
Abbara S1, Blanke P2, Maroules CD, et al. SCCT guidelines for the performance and acquisition of coronary computed tomographic angiography: A report of the society of Cardiovascular Computed Tomography Guidelines Committee: Endorsed by the North American Society for Cardiovascular Imaging (NASCI). J Cardiovasc Comput Tomogr. 2016;10(6):435-449. PMID: 27780758 Abraham NS, Hlatky MA, Antman EM, et al. ACCF/ACG/AHA 2010 Expert Consensus Document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. Circulation. 2010;122(24):2619-2633. PMID: 21060077 Brilakis ES, Patel VG, Banerjee S. Medical management after coronary stent implantation: a review. JAMA. ...
TY - JOUR. T1 - Personalizing the treatment of women with early breast cancer. T2 - Highlights of the st gallen international expert consensus on the primary therapy of early breast Cancer 2013. AU - Goldhirsch, A.. AU - Winer, E. P.. AU - Coates, A. S.. AU - Gelber, R. D.. AU - Piccart-Gebhart, M.. AU - Thürlimann, B.. AU - Senn, H. J.. AU - Albain, Kathy S.. AU - André, Fabrice. AU - Bergh, Jonas. AU - Bonnefoi, Hervé. AU - Bretel-Morales, Denisse. AU - Burstein, Harold. AU - Cardoso, Fatima. AU - Castiglione-Gertsch, Monica. AU - Coates, Alan S.. AU - Colleoni, Marco. AU - Costa, Alberto. AU - Curigliano, Giuseppe. AU - Davidson, Nancy E.. AU - Leo, Angelo Di. AU - Ejlertsen, Bent. AU - Forbes, John F.. AU - Gelber, Richard D.. AU - Gnant, Michael. AU - Goldhirsch, Aron. AU - Goodwin, Pamela. AU - Goss, Paul E.. AU - Harris, Jay R.. AU - Hayes, Daniel F.. AU - Hudis, Clifford A.. AU - Ingle, James N.. AU - Jassem, Jacek. AU - Jiang, Zefei. AU - Karlsson, Per. AU - Loibl, Sibylle. AU - ...
Background/Aims: A large amount of new data on the treatment of chronic hepatitis B has become available such that the 2003 consensus statement requires revision and update.. Methods: New data were presented, discussed and debated in an expert pre-meeting to draft a revision. The revised contents were finalized after discussion in a general meeting of APASL.. Results: Conceptual background, including the efficacy and safety profile of currently available and emerging drugs, was reviewed. Nineteen recommendations were formed and unresolved issues and areas for further study were suggested.. Conclusion: The current therapy of chronic hepatitis B is modestly effective but not satisfactory. The development of new drugs and new strategies is required to further improve the outcomes of treatment. ...
Orthopedics Today reported that ankle surgeons around the world met at the International Consensus Meeting on Cartilage Repair of the Ankle, where they discussed the best ways to treat ankle cartilage injuries and established a consensus for all surgeons. John G. Kennedy, MD, foot and ankle surgeon at HSS and co-founder of the International Soc...
Welcome to Fats of Life. This is a hub for health on the benefits of EPA and DHA omega-3s intended only for medical practitioners.. If you are a patient researching omega-3s please visit our consumer website ...
Welcome to Fats of Life. This is a hub for health on the benefits of EPA and DHA omega-3s intended only for medical practitioners.. If you are a patient researching omega-3s please visit our consumer website ...
Key clinical point: A group of hematology specialists provided consensus statements on the evaluation of bleeding in patients with acquired hemophilia.Major finding: If expert hematologist consultation is not available, and the bleeding event is life‐threatening, the emergency physician should initiate treatment in accordance with local or national recommendations.Study details: Consensus recommendations provided by 36 global experts in acquired hemophilia.
The Delphi method is widely used in education as a technique to lead individual expert opinions to group consensus [22]. Although criticised within the literature for its lack of scientific merit [23], the Delphi method continues to be widely used as a valuable tool to establish guidelines, standards, policy documents and for predicting trends [24, 25]. Typically, the Delphi process comprises of a series of three rounds to 1) present the information and allow respondents the flexibility to elaborate on the content and make suggestions; 2) feed results back and present more specific information and 3) feed results back and give the respondent the opportunity to comment on why their opinion remains outside the consensus.. To apply the Delphi technique to the aims and objectives of creating standards for training content in postgraduate respiratory physiotherapy, three broad elements were considered in the design and presentation of this process:. 1. Nomination of the expert panel and number of ...
Ackerman MJ., Priori SG., Willems S., Berul C., Brugada R., Calkins H., Camm AJ., Ellinor PT., Gollob M., Hamilton R., Hershberger RE., Judge DP., Le Marec H., McKenna WJ., Schulze-Bahr E., Semsarian C., Towbin JA., Watkins H., Wilde A., Wolpert C., Zipes DP., Heart Rhythm Society (HRS) None., European Heart Rhythm Association (EHRA) None ...
Society for Translational Medicine expert consensus on training and certification standards for surgeons and assistants in minimally invasive surgery for lung cancer
Background:Women with autoimmune rheumatic diseases (ARDs) find it difficult to get information and support with family planning, pregnancy, and early parenting. A systematic approach to prioritising research is required to accelerate development and evaluation of interventions to meet the complex needs of this population. Methods:A Nominal Group Technique (NGT) exercise was carried out with lay and professional stakeholders (n=29). Stakeholders were prepared for debate through presentation of available evidence. Stakeholders completed three tasks to develop, individually rank, and reach consensus on research priorities: Task 1 - mapping challenges and services using visual timelines; Task 2 - identifying research topics; Task 3 - individually ranking research topics in priority order. Results of the ranking exercise were fed back to the group for comment. Results:The main themes emerging from Task 1 were the need for provision of information, multi-disciplinary care, and social and peer ...
On December 7, 2020, cannabis industry leaders, former federal government officials, and leading state regulators met for a Virtual Public Policy Summit,
Background/objectives: This paper is part of the international consensus guidelines on chronic pancreatitis, presenting for interventional endoscopy. Methods: An international working group with experts on interventional endoscopy evaluated 26 statements generated from evidence on 9 clinically relevant questions. The Grading of Recommendations Assessment, Development, and Evaluation approach was used to evaluate the level of evidence. To determine the level of agreement, a nine-point Likert scale was used for voting on the statements. Results: Strong consensus was obtained for 15 statements relating to nine questions including the recommendation that endoscopic intervention should be offered to patients with persistent severe pain but not to those without pain. Endoscopic decompression of the pancreatic duct could be used for immediate pain relief, and then offered surgery if this fails or needs repeated endoscopy. Endoscopic drainage is preferred for portal-splenic vein thrombosis and ...
WASHINGTON, D.C., and DALLAS (March 17, 2014) - The increasing number of percutaneous coronary interventions (PCIs) being performed at low-volume centers without on-site cardiac surgery backup has driven the need for new safety and quality protocols, according to an expert consensus document released today and written by a committee representing the Society for Cardiovascular Angiography and Interventions (SCAI), the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA). The document outlines steps hospitals can take to provide the safest possible environment for PCI when the facility does not provide cardiac surgery as a backup should complications occur.
Therefore, European Liver Patients Association (ELPA) invited leading psychologists, psychiatrists and hepatologists to an expert conference in 2011. Martin Schaefer MD and his colleagues reviewed the scientific data and discussed their experience in the treatment of hepatitis C related psychiatric problems. The results were first presented at the EASL conference in Berlin in 2011. Since the conference, the recommendations were refined and updated further to include the new antiviral treatments, and will now be published as a European Expert Consensus Statement in the Journal of Hepatology ...
These Expert Consensus Statements (ECS) were developed by the AAO-HNSF. ECS reflect opinions synthesized from an organized group of…
October 15, 2012 -- The European Society of Gastrointestinal and Abdominal Radiology (ESGAR) has published its first update on CT colonography (CTC) guidelines since 2007. Its working group on CTC has endorsed 86 statements, reaching near-complete agreement on 71 of the 86 items relating to critical practice areas affecting CTC.. Agreement was most consistent in the areas of colon distension, scan parameters, use of intravenous contrast agents, patient preparation, and the role of computer-aided detection (CAD) and lesion measurement. Less than unanimous accord was seen in the use of spasmolytics, decubitus positioning and the number of CT data acquisitions, fecal tagging, 2D versus 3D reading, and reporting.. Over the last five years, expansion of the CT colonography literature has continued and several important studies, including multicenter studies, have been published, wrote Dr. Emanuele Neri and colleagues from six EU countries on behalf of the ESGAR CTC working group. These new data ...
This is a clinical practice guideline on the appropriate use of immunotherapy for the treatment of patients with bladder cancer, specifically non-muscle invasive bladder cancer, muscle invasive bladder cancer, and advanced bladder cancer. The guideline addresses issues related to the definition of risk categories, patient selection, toxicity management, clinical endpoints, as well as the combination and sequencing of therapies. The guideline also highlights areas for future direction and development to advance the use of immunotherapy in bladder cancer treatment.. ...
TY - JOUR. T1 - International consensus on preliminary definitions of improvement in adult and juvenile myositis. AU - Rider, Lisa G.. AU - Giannini, Edward H.. AU - Brunner, Hermine I.. AU - Ruperto, Nicola. AU - James-Newton, Laura. AU - Reed, Ann M.. AU - Lachenbruch, Peter A.. AU - Miller, Frederick W.. PY - 2004/7. Y1 - 2004/7. N2 - Objective. To use a core set of outcome measures to develop preliminary definitions of improvement for adult and juvenile myositis as composite end points for therapeutic trials. Methods. Twenty-nine experts in the assessment of myositis achieved consensus on 102 adult and 102 juvenile paper patient profiles as clinically improved or not improved. Two hundred twenty-seven candidate definitions of improvement were developed using the experts consensus ratings as a gold standard and their judgment of clinically meaningful change in the core set of measures. Seventeen additional candidate definitions of improvement were developed from classification and regression ...
Make better use of current drugs and treat as soon as possible, says Dr Alexandre Mebazaa, lead author of new European recommendations on acute heart failure.
The main strategy for preventing VTE-related mortality is thromboprophylaxis, but guidance regarding its use differs across specialties and organizations. For this reason, the National Partnership for Maternal Safety (NPMS), a group made up of a variety of leaders in womens health care, has created a safety bundle to review current guidance and make recommendations regarding venous thromboembolism during pregnancy.
Patients suffering from cardiovascular autonomic failure often develop neurogenic supine hypertension (nSH), i.e., high blood pressure (BP) in the supine p
Roy Freeman;Wouter Wieling;Felicia Axelrod;David Benditt;Eduardo Benarroch;Italo Biaggioni;William Cheshire;Thomas Chelimsky;Pietro Cortelli;Christopher Gibbons;David Goldstein;Roger Hainsworth;Max Hilz;Giris Jacob;Horacio Kaufmann;Jens Jordan;Lewis Lipsitz;Benjamin Levine;Phillip Low;Christopher Mathias;Satish Raj;David Robertson;Paola Sandroni;Irwin Schatz;Ron Schondorff;Julian Stewart;Gert van Dijk; + Author Information ...
ADI aims to provide the public with an improved understanding of the benefits of implantology, and Members with the benefits of continuous skills development and safeguarding of standards.
TY - JOUR. T1 - OARSI recommendations for the management of hip and knee osteoarthritis, Part II. T2 - OARSI evidence-based, expert consensus guidelines. AU - Zhang, W.. AU - Moskowitz, R. W.. AU - Nuki, G.. AU - Abramson, S.. AU - Altman, R. D.. AU - Arden, N.. AU - Bierma-Zeinstra, S.. AU - Brandt, K. D.. AU - Croft, P.. AU - Doherty, M.. AU - Dougados, M.. AU - Hochberg, M.. AU - Hunter, D. J.. AU - Kwoh, K.. AU - Lohmander, L. S.. AU - Tugwell, P.. PY - 2008/2. Y1 - 2008/2. N2 - Purpose: To develop concise, patient-focussed, up to date, evidence-based, expert consensus recommendations for the management of hip and knee osteoarthritis (OA), which are adaptable and designed to assist physicians and allied health care professionals in general and specialist practise throughout the world. Methods: Sixteen experts from four medical disciplines (primary care, rheumatology, orthopaedics and evidence-based medicine), two continents and six countries (USA, UK, France, Netherlands, Sweden and Canada) ...
August 28, 2013 - Experts have found that radiation dosage can have serious complications for patients with cancer. Cancer patients who receive chest radiation should be evaluated for heart disease before beginning radiation, and every five to 10 years afterward, according to the American Society of Echocardiography (ASE) and the European Assn. of Cardiovascular Imaging (EACVI) of the European Society of Cardiology (ESC). This expert consensus statement on the use of imaging to detect radiation-induced heart disease (RIHD) will be published in the September issue of the Journal of the American Society of Echocardiography (JASE). The writing group was co-chaired by Vuyisile Nkomo, M.D., an echocardiographer from the renowned Mayo Clinic in Rochester, Minn.. When asked about the need for this expert consensus statement, Nkomo said, In the past, patients received high doses of radiation to the chest to treat breast cancer or lymphoma or esophageal cancer, but without adequate shielding of the ...
Dr Ileana Piña discusses a new guideline on atrial fibrillation and a consensus statement addressing cardiovascular toxicity in cancer treatment.
Table of Contents Table of Contents 1. Introduction 2. Consensus Statements on Ridge Augmentation and Review of the Literature 2.1. Consensus Statements and Treatment Guidelines Formulated at the 2008 ITI Consensus Conference 2.1.1. Consensus Statement...
The Delphi process, which was carried out over a period of nine months consisted of a pilot round, two written rounds and a final face-to-face meeting. Sixty infectious disease experts who were national experts in the field of infectious diseases who working at senior levels nationally and internationally, and represented their country on the Advisory Forum of the European Centre for Disease Control, Stockholm (ECDC) were approached. Of the 60, 47 accepted the invitation-written consent was obtained from them. Thirty-eight experts (from 22 countries) participated in the 1st written round and 28 experts (from 19 countries) in the 2nd written round; and 11 newly recruited experts with similar expertise as the participants from the written rounds (as five panellists invited from the written rounds were not able to participate ) from 9 countries participated in the face-to-face meeting. A possible explanation for this is that as national experts, they were extremely busy, and also the panelists were ...
Health,... Patient safety in hospitals focus of 48 NQF-endorsed measures ...WASHINGTON May 15 -- Recognizing that patient... It has been difficult to make real progress in patient safety in this...NQF-endorsed voluntary consensus standards are widely viewed as the g...,National,Quality,Forum,Endorses,Consensus,Standards,for,Quality,of,Hospital,Care,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
BACKGROUND AND PURPOSE: Transcranial color-coded duplex sonography has become a standard diagnostic technique to assess the intracranial arterial status in acute stroke. It is increasingly used for the evaluation of prognosis and the success of revascularization in multicenter trials. The aim of this international consensus procedure was to develop recommendations on the methodology and documentation to be used for assessment of intracranial occlusion and for monitoring of recanalization. METHODS: Thirty-five experts participated in the consensus process. The presented recommendations were approved during a meeting of the consensus group in October 2008 in Giessen, Germany. The project was an initiative of the German Competence Network Stroke and performed under the auspices of the Neurosonology Research Group of the World Federation of Neurology. RESULTS: Recommendations are given on how examinations should be performed in the time-limited situation of acute stroke, including criteria to assess ...
Now that ISO-55000 has been published, many individuals and organizations are questioning if they should adopt it. Here is one more reason for companies to investigate ISO-55000 and see if it has application in their business. It is Office of Management and Budget (OMB) Circular No. A-119 ( . What is the purpose of this document? It clearly states in section 1 that this Circular directs agencies to use voluntary consensus standards in lieu of government-unique standards. ISO-55000 is considered a voluntary consensus standard. Some other points in the circular that I found interesting: 1. Section 6 - All federal agencies must use voluntary consensus standards in lieu of government-unique standards in their procurement and regulatory activities, except where inconsistent with law or otherwise impractical. Consider OSHA, EPA, FDA, etc. 2. Section 6a - Your agency must use voluntary consensus standards, both domestic and international, in its ...
Second international consensus on the methodology and criteria of evaluation of angiogenesis quantification in solid human tumours ...
Governmental and private organizations often develop recommendations for the prevention, diagnosis, and treatment of various disorders. These recommendations regarding appropriate clinical decisions are usually made by a group of experts after they assess the available evidence. Recommendations may be published as consensus statements developed at a conference or as clinical practice guidelines (sometimes called practice parameters) developed over time. In either case, publication of the recommendations should identify the sponsor and the participating experts, explain how the participants were selected, describe the evidence that supports the recommendations, and explain the process for achieving consensus in reaching the conclusions. Structured abstracts
CIPO is pleased to be part of a coalition of Canadian Patient organizations that came together through the International Federation on Ageing (IFA), to discuss adult influenza vaccination. On September 5 the IFA is pleased to release the consensus statement Uniting Diverse Groups to Improve Adult Influenza Vaccination in Canada as a result of the Adult Influenza Vaccination: Calling Canadian Patient Organizations to Action expert meeting held in June 2019. This consensus statement is an important step forward in forming a cohesive voice that supports improvements in vaccination practices in Canada.. Press Release - Consensus Statement. Consensus Statement - Uniting Diverse Groups to Improve Adult Influenza Vaccination. ...
TY - JOUR. T1 - 2014 Consensus Statement from the first Economics of Physical Inactivity Consensus (EPIC) Conference (Vancouver). AU - Davis, J.C.. AU - Verhagen, E.A.L.M.. AU - Bryan, S.. AU - Liu-Ambrose, T.. AU - Borland, J.. AU - Buchner, D.. AU - Hendriks, M.R.C.. AU - Weiler, R.. AU - Morrow, J.R.. AU - van Mechelen, W.. AU - Blair, S.N.. AU - Pratt, M.. AU - Windt, J.. AU - al-Tunaiji, H.. AU - Macri, E.. AU - Khan, K.M.. PY - 2014. Y1 - 2014. U2 - 10.1136/bjsports-2014-093575. DO - 10.1136/bjsports-2014-093575. M3 - Article. C2 - 24859181. VL - 48. SP - 947. EP - 951. JO - British Journal of Sports Medicine. JF - British Journal of Sports Medicine. SN - 0306-3674. IS - 12. ER - ...
TY - JOUR. T1 - Comparison of four methods for assessing the importance of attitudinal beliefs. T2 - An international Delphi study in intensive care settings. AU - Francis, Jill J. AU - Duncan, Eilidh M. AU - Prior, Maria E. AU - Maclennan, Graeme. AU - Marshall, Andrea P. AU - Wells, Elisabeth C. AU - Todd, Laura. AU - Rose, Louise. AU - Campbell, Marion K. AU - Webster, Fiona. AU - Eccles, Martin P. AU - Bellingan, Geoff. AU - Seppelt, Ian M. AU - Grimshaw, Jeremy M. AU - Cuthbertson, Brian H. AU - for the SuDDICU study groups. N1 - © 2013 The British Psychological Society.. PY - 2014/5. Y1 - 2014/5. N2 - Behaviour change interventions often target important beliefs. The literature proposes four methods for assessing importance of attitudinal beliefs: elicitation frequency, importance ratings, and strength of prediction (bivariate and multivariate). We tested congruence between these methods in a Delphi study about selective decontamination of the digestive tract (SDD). SDD improves ...
Recommendations for the practical management of CRT patients have been set out for the first time in an international consensus statement on cardiac resynchronization therapy (CRT) in heart failure.
William (Bill) Hordern". Consensus. 35 (2). art. 2. Retrieved February 15, 2019. Kamminga, Menno R. (2012). "Structure and Sin ...
Enns, Elaine L. (2016). "Trauma and Memory: Challenges to Settler Solidarity". Consensus. 37 (1): 1-11. ISSN 2369-2685. OCLC ...
Consensus. Retrieved 12 October 2022. Mohammad, Ali Shomali (2008). Shi'i Islam.pdf "The Meaning of the term Shi'a" (PDF). The ...
Erb, Peter (1996-11-01). "Dialectic and narrative in Aquinas; The soul as virgin wife; On evil (3 books)". Consensus. 22 (2). ...
Consensus decision-making False-consensus effect Groupthink Pluralistic ignorance Robert, Henry M. (2011). Robert's Rules of ... Robert's Rules of Order notes that this was part of the impetus for switching from consensus to majority as the voting basis in ... A pseudoconsensus is a false consensus, reached most commonly when members of a group feel they are expected to go along with ... Tools to Grow Ecovillages identifies pseudoconsensus as a problem that can occur in communal environments with a consensus ...
Nation state 319-323.......Political Geography 327...........Sovereignty 328.2.........Consensus. Consent of the governed 328.6 ...
Tucker, Ansley (1986). "The Historic Episcopate in Anglican Ecclesiology: The Esse Perspective". Consensus. 12 (1): 99-115. ...
Enns, Elaine L. (2016). "Trauma and Memory: Challenges to Settler Solidarity". Consensus. 37. Smith, p. 314-315. The Makhnos of ... Accessed from: Epp, Marlene Mennonite Women in ...
London : S.P.C.K. "The historic episcopate in Anglican ecclesiology the esse perspective". Consensus. 12 (1). 1986. ISSN 2369- ...
"Consensus! Engineering students need more management education." Journal of Management in Engineering 12.6 (1996): 17-29. " ...
"Hunger and Malnutrition". Copenhagen Consensus. Retrieved 2 September 2018. Behrman, Jere; Hoddinott, John (2005). "Program ... Hoddinott together with Jere Behrman and Harold Alderman authored a report for the Copenhagen Consensus that attempted to ...
"Kedarnath Population Census 2011 - 2022". Consensus 2011. "Pilgrim influx to Kedarnath Dham crosses 10.08 lakh, breaks all ...
Copenhagen Consensus. Archived from the original on 16 April 2016. Retrieved 7 April 2016. "Statistics". UNICEF. 18 December ... "Bangladesh Priorities: Poverty, Sulaiman and Misha , Copenhagen Consensus Center". ...
Critical Consensus. Retrieved October 17, 2017. Ebert 2008, p. 282. Ebert, Roger (June 28, 2011). "Woody Allen meets Jean-Luc ...
"Scientific Consensus , LymeScience". LymeScience. Archived from the original on October 21, 2021. Retrieved April 22, 2021. ...
... is a method of avoiding the consensus trap, in which the lack of consensus leads to inaction. Scott McNealy ... "Consensus trap , World Problems & Global Issues". The Encyclopedia of World Problems. Retrieved July 3, 2017. Lencioni, Patrick ... Great teams avoid the consensus trap by embracing a concept that Intel, the legendary microchip manufacturer, calls "disagree ...
Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC (August 1999). "Consensus statement. Global burden of tuberculosis: ...
Consensus Economics, publisher of Consensus Forecasts, a monthly publication with macroeconomic forecasts of 85 countries based ... Batchelor, Roy (August 2000). "The IMF and OECD versus Consensus Forecasts" (PDF). Consensus Economics. Archived from the ... in some cases comparing these to consensus forecasts such as those published by Consensus Economics.[citation needed] A 2000 ... A 2001 paper by Roy Batchelor of City University Business School, London compared the Consensus Forecasts with forecasts made ...
"Scientific Consensus , LymeScience". LymeScience. Retrieved April 22, 2021. "Gigi Hadid wins $25,000 for charity in cooking ...
The Consensus Tigurinus lays out an explanation of the doctrine of the Sacraments in general, and specifically, that of Holy ... Growing Consensus II: Church Dialogues in the United States, 1992-2004. Bishop's Committee for Ecumenical and Interreligious ... in seeking to come to consensus about the Real Presence, the churches have written: During the Reformation both Reformed and ... ". "Consensus Tigurinus". Archived from the original on 2 October 2009. Reasoning From The Scriptures, Watch Tower Bible & ...
Jakobson, Leo (31 December 2019). "Justin Sun's BitTorrent buys DLive streaming platform". Modern Consensus. Archived from the ...
"How does Nunavut's consensus government work?". CBC News. 28 October 2017. Retrieved 20 March 2020. "Consensus Government , ... The Legislative Assembly of Nunavut is a public government and operates on the consensus model. Members of the Legislative ...
"Psychonauts 2 is vintage Double Fine in strengths and flaws , Critical Consensus". August 24, 2021. Celia Pearce (March 7, 2003 ...
"10 Smartest NFL Players". College Consensus. December 20, 2018. Archived from the original on June 24, 2019. Retrieved ...
"Copenhagen Consensus 2012 - Outcomes". Copenhagen Consensus. Retrieved 14 May 2012. "World Malaria Report 2011". World Health ... As part of the Copenhagen Consensus 2012, a panel of leading economists concluded that the AMFm was "one of the best returns on ...
Dublin, Consensus. "The Dublin Consensus Statement on vital issues relating to the collection of blood and plasma and the ... and Dublin Consensus (2010). The IFBDO was founded in Luxembourg on December 4, 1955. The Headquarters are established in ...
Vowles, Jack (2013). Towards Consensus?: The 1993 Election and Referendum in New Zealand and the Transition to Proportional ...
"Thomas Schelling". Copenhagen Consensus. Retrieved January 16, 2016. "NAS Award for Behavior Research Relevant to the ... Schelling was a contributing participant of the Copenhagen Consensus. In 1977, Schelling received The Frank E. Seidman ...
The goal is to rule by a consensus decision making process. Strong local coalitions are considered a prerequisite to higher- ... "Spinifex 4, Newsletter of the 2001 Global Greens Congress" (PDF). Consensus Productions. "Alain LIPIETZ à BOGOTA du 3 au 5 mars ... based on direct citizen involvement and consensus decision making, wherever it is feasible. Green politics also encourages ...
Arctic Consensus 2018. Lindstrøm 2020. Veirum 2020: "chokerende stort omfang". Sermitsiaq 2021. Søndergaard & Fallesen 2021. ... Arctic Consensus. 25 April 2018. Retrieved 3 December 2021. "Om filmen" [About the film]. Kampen om Grønland. Retrieved 3 ...
The baker is a daemon that executes Tezos consensus algorithm. The baker runs on behalf of one or more specified accounts or, ... Sometimes there is no consensus at a round, so it is worth considering also baking rights at higher rounds, like 2 in the ... A minimal active stake of 6kꜩ is required for participating in consensus and in governance. ... and emits consensus operations like endorsements. It does so whenever the associated accounts have the necessary rights. ...
This survey is aimed at collecting some basic information on the degree of awareness and consensus of people involved with ...
Appropriate Use of Voluntary Consensus Standards in Premarket Submissions for Medical Devices - Guidance for Industry and Food ...
The consensus statement was published online today in JAMA Dermatology.. The Need for Guidance Although focusing melanoma ... Melanoma Screening: Consensus Statement Offers Greater Clarity * Neoantigen Vaccine With Pembrolizumab Has Clear Benefit in ... The panel then came together for a consensus conference, which included 51 experts who discussed their approach to the various ... However, the panelists did not reach consensus on the role for gene expression profile (GEP) testing in clinical decision- ...
7) When consensus is declared hurriedly or before it even exists.. A well-rooted scientific consensus, like a mature oak, ... A scientific consensus should be based on scientific evidence. But a consensus is not itself the evidence. And with really well ... When scientists rush to declare a consensus, particularly when they claim a consensus that has yet to form, this should give ... Even without the scandal, the very idea of scientific consensus should give us pause. "Consensus," according to Merriam-Webster ...
... Plurality consensus sequences are returned in the main folder and are named after the virus genome or ... The second type of base amendment is for consensus allele quality control. IRMA uses both the average consensus allele quality ... amended_consensus. sub-folder depending on the configuration. These sequences are modifications to the plurality consensus. ... It can be useful to differentiate these regions from deletions in the amended consensus. If one sets PADDED_CONSENSUS=1. ( ...
Momentum are being attacked because they threaten Westminsters consensus. Corbyns strength comes from his wider support in ... for a new and genuine left and a rejection of the failed Westminster consensus. It therefore has the potential to pose one of ...
Appropriate Use of Voluntary Consensus Standards in Premarket Submissions for Medical Devices - Guidance for Industry and Food ...
Title:Learning the Exact Topology of Undirected Consensus Networks. Authors:Saurav Talukdar, Deepjyoti Deka, Sandeep Attree, ... The main contribution of this work is to show that in the case of undirected consensus networks, all spurious links obtained ... To the best of our knowledge this is the first approach that provably reconstructs the structure of undirected consensus ... we present a method to learn the interaction topology of a network of agents undergoing linear consensus updates in a non ...
He has participated in various roles since 2004 in the Copenhagen Consensus project, ranging from author of challenge papers to ... The Post-2015 Consensus project brings together 60 teams of economists with NGOs, international agencies and businesses to ...
In it, the team lays out what they call "consensus on consensus" and draws from seven independent consensus studies by the co- ... Consensus on Consensus. Expertise Matters in Agreement Over Human-Caused Climate Change. ... There are many surveys about climate change consensus. The problem with some surveys, Green points out, is that they are biased ... "Whats important is that this is not just one study-its the consensus of multiple studies," Green says. This consistency ...
The GNU consensus community gathers on the Freenode IRC channel #consensus. GNU consensus Wiki. Work in progress is available ... The GNU consensus may produce software: when it does, it is free software; you can redistribute it and/or modify it under the ... Due to the nature and youth of the project, we currently provide a unique list ,,. As the project evolves, ... GNU consensus is currently being maintained by hellekin. Please use the mailing lists for contact.. Licensing. ...
2001)‎. Consensus Report on STI, HIV and AIDS Epidemiology : Malaysia, 2001. WHO Regional Office for the Western Pacific. https ...
2010)‎. Data sharing: reaching consensus. Bulletin of the World Health Organization, 88 (‎6)‎, 468. World Health Organization. ...
The consensus statement, highlighted in the last issue of Nature Energy, updates the ISOS protocols for the stability ... A consensus statement establishes the protocols to assess and report stability of perovskite photovoltaic devices Peer-Reviewed ... A consensus statement establishes the protocols to assess and report stability of perovskite photovoltaic devices. Skolkovo ... The result of the discussion is a consensus statement published in Nature Energy and highlighted in the journal editorial. The ...
... TCP Home. My Ratings. Rate Abstracts. FAQ. Visualization. Search. ...
Filed Under: Blog, President Posts Tagged With: consensus, guidelines, president, technology, value assessment, w. scott melvin ...
Today, the National Academies of Sciences, Engineering, and Medicine published a Consensus Study Report, Frameworks for ... Release of National Academies Consensus Study Report on Protecting Workers and the Public from Inhalation Hazards. ...
Source URL (modified on 2019-01-07 12:50): ...
U.S. Senate Report: CONSENSUS EXPOSED, PART 3: HIDE THE DECLINE Read the Full Article ...
Overwatch 2 , Critical Consensus The follow up to the 2016 hero shooter is here but critics debate whether it feels like a full ...
blockchainconsensus. Contact author(s). runting @ gmail com History. 2020-11-12: last of 4 revisions. 2018-04-03: received. See ... Rethinking Large-Scale Consensus. Rafael Pass and Elaine Shi Abstract. In this position paper, we initiate a systematic ... Finally, we survey recent results including how to avoid well-known painpoints in permissionless consensus, and how to apply ... We prove several simple but hopefully insightful lower bounds that demonstrate exactly why reaching consensus in a ...
... "consensus," a general agreement) by a group or culture. That is, if enough people believe some concept is "real," whether it is ... be a form of consensus reality. There is now a belief that educated and influential people knew the Earth was spherical, and ...
Consensus is a crucial concept in understanding blockchain and cryptocurrency. Read more about consensus here. ... What role does consensus play in blockchain and cryptocurrency?. Consensus is used by several cryptocurrencies, including ... What is consensus?. In blockchain technology, the consensus mechanism formalizes an agreement in which the majority, or at ... Pros and cons of consensus. One of the most important features of consensus is that it helps synchronize data through the ...
By now an outgrowth, manufacturing consensus has become a science, a way to leverage computational propaganda to spin ... information flows over social media. We are introduced here to a dazzling array of systems of manufacturing consensus in the ...
... "systematically influenced the Fed Reserve presidents in their voting behavior towards a consensus." ...
This website uses cookies so that we can provide you with the best user experience possible. Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful.. ...
The consensus view of crime regards crime as "illegal behavior defined by existing criminal law," as described by Dr. Larry J. ... In the consensus view, what is defined as crime emerges from general agreement among the citizenry. The lawmakers criminalize ... What Is the Consensus View of Crime?. By Staff WriterLast Updated April 03, 2020 ... The consensus view contrasts significantly with the conflict and interactionist views, which both hold that the definition of ...
consensus. Reuters. Court and legislatures in the Americas have increasingly found that defamation should be a civil matter. ...
  • Appropriate Use of Voluntary Consensus Standards in Premarket Submissions for Medical Devices - Guidance for Industry and Food and Drug Administration Staff, issued September 2018. (
  • TL;DR - Who/What/Where/When/Why of Consensus 2018. (
  • Consensus 2018, put on by CoinDesk , is the 4th iteration of the annual blockchain technology summit. (
  • Consensus 2018 will feature more than 250 speakers, 4,000 attendees, as well as many leaders from financial institutions, academic/policy groups, and investment entities. (
  • Simply put, when it occurs, Consensus 2018 will be the largest cryptocurrency event yet seen in North America. (
  • Consensus Model Retrieved September 2018 from Consensus Model for APRN Regulation. (
  • On November 17, 2022, Ethereum developers gathered for their 98th Consensus Layer (CL) call. (
  • IMSEAR at SEARO: Consensus statement on evaluation of hematuria. (
  • IMSEAR at SEARO: Consensus Statement of the Indian Academy of Pediatrics on Integrated Management of Severe Acute Malnutrition. (
  • What role does consensus play in blockchain and cryptocurrency? (
  • Every cryptocurrency relies on consensus to legitimize the transactions. (
  • The consensus mechanism influences the validation of cryptocurrency transactions, network fees, the efficiency of transactions, and how many resources are used to complete those transactions. (
  • Consensus is a unique event in the cryptocurrency and blockchain space on a number of levels, not the least of which being the sheer size and scope of the event itself. (
  • Member countries of the Group of 20 (G20) have announced a plan to build consensus on cryptocurrency policy. (
  • Member countries of the Group of 20 (G20) are currently considering creating a policy consensus on cryptocurrency, following the fiasco in the industry spurred by the collapse of Sam Bankman-Fried's crypto exchange, FTX. (
  • Many of the doubt-inducing climate scientists and their media acolytes attribute this rising skepticism to the stupidity of Americans, philistines unable to appreciate that there is "a scientific consensus on climate change. (
  • One of the benefits of the recent Climategate scandal, which revealed leading climate scientists manipulating data, methods, and peer review to exaggerate the evidence of significant global warming, may be to permanently deflate the rhetorical value of the phrase "scientific consensus. (
  • Even without the scandal, the very idea of scientific consensus should give us pause. (
  • We want to know whether a scientific consensus is based on solid evidence and sound reasoning, or social pressure and groupthink. (
  • No matter how well founded a scientific consensus, there's someone somewhere - easily accessible online - that thinks it's all hokum. (
  • Are we obligated to trust whatever we're told is based on a scientific consensus unless we can study the science ourselves? (
  • I don't know of any exhaustive list of signs of suspicion, but, using climate change as a test study, I propose this checklist as a rough-and-ready list of signs for when to consider doubting a scientific "consensus," whatever the subject. (
  • Only 12 percent of the US public are aware there is such strong scientific agreement in this area, and those who reject mainstream climate science continue to claim that there is a lack of scientific consensus. (
  • The progress made at the United Nations Climate Change Conference (COP21) in Paris late last year indicates that countries are now well and truly behind the scientific consensus, too," Cook says. (
  • The new law is set to go into effect on January 1 and doctors who disseminate information that diverges from the "contemporary scientific consensus" will face persecution. (
  • The doctors argue that "contemporary scientific consensus" is "undefined in the law and undefinable as a matter of logic. (
  • A Scientific Consensus on Global Warming? (
  • Today's climate alert offers a detailed debunking of the notion of a "scientific consensus" on global warming. (
  • The phrase "scientific consensus" suggests something approaching unanimous agreement among scientists. (
  • The theme of scientific consensus creeps into documents such as the Arctic Climate Impact Assessment Overview Report (2004) and the UN Intergovernmental Panel on Climate Change's (IPCC) Third Assessment Report (2001). (
  • Republicans sometimes like to present their support for the individual mandate as a youthful indiscretion, but as late as June 2009, Charles Grassley, the ranking Republican on the Senate Finance Committee, was telling Fox News that "there is a bipartisan consensus to have an individual mandate. (
  • Public Policy Polling: Bipartisan Consensus! (
  • Bipartisan Consensus! (
  • Tawafuq ' as an idea refers to decision-making not through formal processes relying on potentially divisive majorities but rather informal processes relying on tacit acceptance and consensus, with all stakeholders driven by the interests of each and every citizen. (
  • If the majority or certain stakeholders agree, that can mean consensus. (
  • Objectives: To critically evaluate the current global evidence to formulate a consensus among stakeholders regarding diagnosis and management of SAM. (
  • In blockchain technology, the consensus mechanism formalizes an agreement in which the majority, or at least 51%, of network nodes agree that a particular digital transaction was executed and completed in the blockchain network. (
  • One of the most important features of consensus is that it helps synchronize data through the network, building trust in a blockchain. (
  • Located in the heart of New York City, Consensus not only will provide high-quality content and opportunity for structured networking events, but also act as a draw for blockchain events throughout the week. (
  • Detecting melanoma early, when it is easier to treat, remains a "paramount goal," but guidelines surrounding optimal melanoma screening practices and diagnostic evaluations need greater clarity, according to the authors of a new consensus statement . (
  • The consensus statement was published online today in JAMA Dermatology . (
  • The consensus statement, highlighted in the last issue of Nature Energy , updates the ISOS protocols for the stability assessment of perovskite photovoltaics with additional procedures to account for properties specific to this technology. (
  • The result of the discussion is a consensus statement published in Nature Energy and highlighted in the journal editorial. (
  • Dalwai Samir, Choudhury Panna, Bavdekar Sandeep B, Dalal Rupal, Kapil Umesh, Dubey A P, Ugra Deepak, Agnani Manohar Sachdev H P S. Consensus Statement of the Indian Academy of Pediatrics on Integrated Management of Severe Acute Malnutrition. (
  • A Writing Committee was formed and was entrusted with the task of drawing a Consensus Statement on the basis of these Recommendations. (
  • After multiple deliberations, the following Consensus Statement was adopted. (
  • Occlusal Vertical Dimension: Best Evidence Consensus Statement. (
  • Is the American Venous Forum Consensus Statement on Lymphedema Helpful? (
  • Linda Girgis, MD, discusses the trials and treatment of congenital lymphedema, considering the American Venous Forum consensus statement. (
  • A modified Delphi process based on the integration of evidence provided by the literature and expert opinions-using a sequential approach to avoid biases and misinterpretations-was used to generate the final consensus statement. (
  • Conclusions We present a consensus statement and clinical practice recommendations on fluid therapy for neurointensive care patients. (
  • Social consensus prevented Bitcoin being stripped of its integrity even when technically the transaction could be reversed. (
  • In 1996, Consensus Orthopedics acquired US Medical Products becoming a global manufacturer of reliable large joint orthopedic devices. (
  • Since 1996, Consensus Orthopedics has been providing the orthopedic industry with exceptional hip and knee joint replacement devices. (
  • However, stubborn insistence on an eccentric position, with refusal to consider other viewpoints in good faith, is not justified under Wikipedia's consensus practice. (
  • Many of us use consensus-style decision making in our free/open source projects such as Apache's lazy consensus model, but often we have a practice or even a governance of having things end up in a majority-wins voting process. (
  • Clinical practice guidelines on pediatric acute respiratory distress syndrome from the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) were published in February 2023 in Pediatric Critical Care Medicine . (
  • Fluid therapy in neurointensive care patients: ESICM consensus and clinical practice recom. (
  • Objective To report the ESICM consensus and clinical practice recommendations on fluid therapy in neurointensive care patients. (
  • The stimulus for this consensus conference was that, despite previous guidelines, recommendations regarding appropriate testing before therapy were commonly not followed, and testing after therapy was also not recommended for practitioners in the United States," Hashem El-Serag, MD, from the Michael E. DeBakey VA Medical Center, Houston, Texas, and colleagues write. (
  • International Consensus Guidelines for Risk Factors in Chronic Pancreatitis. (
  • This report summarizes these deliberations and details the consensus guidelines. (
  • There are many surveys about climate change consensus. (
  • He says consensus studies have helped change political dialogue around climate change. (
  • Co-author Naomi Oreskes from Harvard University originally pursued consensus data about climate change in 2004 and co-wrote Merchants of Doubt, which was turned into a documentary in 2014. (
  • Adapted from "Consensus Doesn't Mean Everyone Agrees," Linda Finkle, Incedo Group, (
  • There's not much Democrats and Republicans agree on these days but in a time where politicians are pretty universally unpopular there's a consensus across party lines about one thing- they want to keep their elected leaders moving. (
  • However, the panelists did not reach consensus on the role for gene expression profile (GEP) testing in clinical decision-making, citing the need for these assays to be validated in large randomized clinical trials. (
  • To provide consensus recommendations on optimal screening practices, prebiopsy and postbiopsy diagnostics, and prognostic assessment of cutaneous melanoma, a group of 42 panelists voted on hypothetical scenarios via an emailed survey. (
  • The panelists reached a consensus, with 70% agreement, to support a risk-stratified approach to melanoma screening in clinical settings and public screening events. (
  • In the prebiopsy setting, panelists reached consensus that visual and dermoscopic examination was appropriate for evaluating patients with "no new, changing, or unusual skin lesions or with a new lesion that is not visually concerning. (
  • The panelists also reached consensus that lesions deemed clinically suspicious for cancer or showing features of cancer on reflectance confocal microscopy should be biopsied. (
  • Although panelists agreed that a low-risk prognostic GEP score should not outweigh concerning histologic features when patients are selected to undergo sentinel lymph node biopsy (SLNB), they did not reach consensus for imaging recommendations in the setting of a high-risk prognostic GEP score and low-risk histology and/or negative nodal status. (
  • A series of clinical scenarios centered on 1 or the 3 etiologic groups (IPAH, CTD-associated PAH, and portopulmonary hypertension) were presented to the panelists for the development of the consensus. (
  • Overall, a total of 14 consensus statements on the use of oral prostacyclin pathway agents that included 13 clinical scenarios where selexipag may be considered were discussed by the panelists. (
  • Please read the GNU consensus Manifesto . (
  • In fact, one of the priorities that has been put on the table is to help countries reach consensus on the policy approach to crypto assets. (
  • Results of an expert consensus survey on the treatment of pulmonary arterial hypertension with oral prostacyclin pathway agents [published online November 16, 2019]. (
  • Plurality consensus sequences are returned in the main folder and are named after the virus genome or gene segment class label, see the IRMA output page for more details . (
  • IRMA uses both the average consensus allele quality score as well as the consensus allele coverage depth. (
  • The plurality consensus sequence is very useful when used with the BAM file to look at minor variants, since the most frequent allele will appear in the reference. (
  • The final plurality consensus and the final reference are the same sequence! (
  • 0 denotes a consensus sequence with no quasispecies analysis. (
  • The panel then came together for a consensus conference, which included 51 experts who discussed their approach to the various clinical case scenarios. (
  • To the best of our knowledge this is the first approach that provably reconstructs the structure of undirected consensus networks with correlated noise. (
  • This coalition of interests, in a sense, mirrors the consensus-based approach of Javanese society. (
  • This paper challenges that conventional wisdom with que sera consensus QSC, an approach to consensus that cleanly decomposes the agreement problem from that of network asynchrony. (
  • The consensus would likely influence global approach to regulating digital currencies, according to India's federal economic affairs secretary, Ajay Seth. (
  • Today, the National Academies of Sciences, Engineering, and Medicine published a Consensus Study Report, Frameworks for Protecting Workers and the Public from Inhalation Hazards external icon , to provide recommendations for the oversight and guidance of respiratory protection in the United States. (
  • A working group of 25 representatives from major academic medical centers and research, government, military, public health and emergency management institutions and agencies developed consensus-based recommendations for measures to be taken by medical and public health professionals following the use of tularemia as a biological weapon against a civilian population. (
  • All other policy recommendations must pass through consensus. (
  • Results The final consensus comprises a total of 32 statements, including 13 strong recommendations and 17 weak recommendations. (
  • Many false ideas enjoyed consensus opinion at one time. (
  • No one can know, at any given time, the 'consensus' of doctors and scientists on various matters related to prevention and treatment of COVID-19," the complaint adds. (
  • Most of the time consensus is reached as a natural product of the editing process. (
  • If we find that a particular consensus happens often, we write it down as a guideline , to save people the time having to discuss the same principles over and over. (
  • If you want 100% consensus before you make a decision, chances are you'll be waiting a long time. (
  • Oddly, when the consensus view is positive on a stock, it may be time to sell. (
  • For some the position taken in the book will be controversial as it amounts to a radical rehabilitation of the two-state consensus at a time when many believe that the settlement dynamic has proceeded past the point of reversibility and the Israeli leadership is positioning itself step by step to embrace a Zionist version of a unilaterally imposed one-state solution to the conflict. (
  • CPU usage, memory usage, disk usage, network bandwidth, synchronization time and number of peers) of the main five consensus clients (i.e. (
  • The Cairo consensus : the right agenda for the right time / Adrienne Germain, Rachel Kyte. (
  • Our results demonstrate for the first time that the consensus IDV HEF DNA vaccine can elicit complete protection against infection from two lineages of IDV in the guinea pig model. (
  • Through this new collaboration, multiple consensus researchers-and their data gathered from different approaches-lead to essentially the same conclusion. (
  • Neonatal sepsis: need for consensus definition, collaboration and core outcomes. (
  • Control for calculating consensus trees is found under the trees menu. (
  • A plurality rule was chosen over majority consensus because it is more inclusive for pattern matching purposes and does not assign strict thresholds for the dominant virus phase in the sample. (
  • Prof. Koh also pointed out that changing the ASEAN consensus-based decision-making process to one that is based on majority vote is impractical and unnecessary, which threatens ASEAN unity. (
  • John Cook from the University of Queensland uses media clips, street interviews and data from his latest paper to demonstrate the consensus gap between experts, non-experts and the public. (
  • We prove several simple but hopefully insightful lower bounds that demonstrate exactly why reaching consensus in a permissionless setting is fundamentally more difficult than the classical, permissioned setting. (
  • This article documents the consensus of an expert group of surgeons from the Second International Trans-anal Total Mesorectal Excision (TaTME) Conference held in Paris in July 2014. (
  • Consensus Conference Next Week! (
  • A new consensus document defining who should be tested and treated for Helicobacter pylori ( H pylori ) infection has been issued by 11 experts after their participation in the Houston Consensus Conference on Testing for H. pylori Infection in the United States. (
  • The unfortunate and inaccurate characterization of consensus is used as a rhetorical bludgeon of skeptics and is the basis of a push for industrialized nations to "do something" to reduce the atmosphere's greenhouse gas concentration. (
  • Sports, Sports Illustrated, CBS Sports, Walter Football, and theScore in order to put together a concensus ranking from experts across the sports world. (
  • These experts discussed the importance of introducing conjugate vaccines for pilgrims and travellers, and elaborated a consensus recommendation to support healthcare professionals and decision-makers. (
  • Avec l'introduction d'une nouvelle génération de vaccins antiméningococciques conjugués quadrivalents (Menveo, Menactra et autres licences en attente) et leur récente mise en œuvre en Arabie saoudite, des experts de 11 pays de la Région du Moyen-Orient se sont réunis au Meningococcal Leadership Forum, à Dubaï, en mai 2010 pour échanger sur la maladie méningococcique et les stratégies de prévention. (
  • Design A consensus committee comprising 22 international experts met in October 2016 during ESICM LIVES2016. (
  • Practices for which insufficient evidence or no consensus regarding efficacy exists. (
  • In this study, we designed a DNA vaccine expressing consensus hemagglutinin-esterase fusion (HEF) protein (FluD-Vax) and tested its protective efficacy against two lineages of IDV (D/OK and D/660) in guinea pigs. (
  • The authors say in their report that Mr. Greenspan, who led the central bank from 1987 to 2006, "systematically influenced the Fed Reserve presidents in their voting behavior towards a consensus. (
  • The consensus view of crime regards crime as "illegal behavior defined by existing criminal law," as described by Dr. Larry J. Siegel in his book, "Criminology. (
  • The consensus view, along with the interactionist and conflict views, are the three perspectives that criminologists take on crime and criminal behavior. (
  • A minimal active stake of 6kꜩ is required for participating in consensus and in governance. (
  • This survey is aimed at collecting some basic information on the degree of awareness and consensus of people involved with science and innovation towards Responsible Research and Innovation (RRI) and Open Science (OS) (for more information, see and ). (
  • Consensus report: Aggressive periodontitis. (
  • The purpose of this project is to perform an external, objective and unbiased evaluation of the different Ethereum Consensus Layer Clients in order to create targets for client decentralization. (
  • We will evaluate the hardware resource consumption of all Ethereum Consensus Layer Clients as well as many other different metrics related to their network bandwidth consumption, number of peers, syncing speed, storage requirements, among many other metrics. (
  • We thought that we would do a small supporter meetup during Consensus because New York, similar to London, is a city with a massive population of both people and pubs. (
  • What Is the Consensus View of Crime? (
  • In the consensus view, what is defined as crime emerges from general agreement among the citizenry. (
  • The consensus view contrasts significantly with the conflict and interactionist views, which both hold that the definition of crime is associated with power in some way. (
  • It is assumed that editors working toward consensus are pursuing a consensus that is consistent with the consensus on how to do things on a wider scale - especially the neutral point of view (NPOV) . (
  • As a result, it is sometimes hard to determine what the consensus is in such processes. (
  • Consensus," according to Merriam-Webster, means both "general agreement" and "group solidarity in sentiment and belief. (
  • A vast group of scientists with Prof. Pavel A. Troshin representing Skoltech has reached a consensus on the suitable procedures and the variables to be reported in stability studies of this kind of solar cells. (
  • Consensus Intl is a company established by a group of experienced consultants who were passionate about solving their clients' problems. (
  • To create the consensus statements, the panel used the RAND/University of California Los Angeles Appropriateness Method, which incorporates the Delphi method and the nominal group technique. (
  • Thus, the consensus group singled out target populations who should be considered for testing and treatment, the intention being to provide practical advice for physicians in the United States who manage patients with potential H pylori infection. (
  • Before the first phase of this project, a consensus process was conducted with a group of safety and health professionals to determine topics and learning objectives for the course. (
  • Williamson proposed the term 'Washington Consensus' to refer to the lowest common denominator of policy advice being addressed by the Washington based institutions. (
  • The Evolution Of The Term 'Washington Consensus' ," Journal of Economic Surveys , Wiley Blackwell, vol. 23(2), pages 350-384, April. (
  • The term "national consensus standard" is specifically defined. (
  • These sequences are modifications to the plurality consensus. (
  • Was Shock Therapy Consistent with the Washington Consensus? (
  • This is how consensus is used as a continuous method to validate which digital wallet owns which assets. (
  • After many years of continuous growth, Consensus has helped more than +900 companies around the world to simplify, streamline and automate their organizations. (
  • With a focus on evidence based medicine, Consensus Orthopedics is changing patient care and the future of orthopedics. (
  • AIMS: The aim of this consensus paper is to review the available evidence on the association between moderate alcohol use, health and disease and to provide a working document to the scientific and health professional communities. (
  • This is where Amir Taaki, a thought leader in crypto space tweeted , "… Strongest evidence yet that crypto is based on social consensus, not purely technical. (
  • Strongest evidence yet that crypto is based on social consensus, not purely technical. (
  • will appear in main folder for the plurality alignment and also in the amended_consensus folder. (
  • The main contribution of this work is to show that in the case of undirected consensus networks, all spurious links obtained using Wiener filtering can be identified using frequency response of the Wiener filters. (
  • Momentum is founded on an enthusiasm, felt by hundreds of thousands of people, for a new and genuine left and a rejection of the failed Westminster consensus. (
  • The consensus mechanism is used to make sure the miners agree on the completed transaction and the information for the new block is distributed to all miners. (
  • For the second route we make consensus trees. (
  • There is another kind of consensus we could make, and for this I have used two different kinds of starting trees, shown in the third row. (
  • To compensate for this, people first simply check if the criterion of supermajority is achieved, and on that basis make a first order assumption on how close one is to rough consensus. (
  • If you create a policy and you are looking for consensus, make sure that you follow these steps before proceeding. (
  • Only the site admin, Joe Beaudoin Jr. , can make a policy official/active without consensus. (
  • The APO Board will make the final selection on a consensus basis during their meeting in June. (
  • Your best bet is to look at the process that produced, maintains, and communicates the ostensible consensus. (
  • The network's nodes must reach an agreement to complete the digital transaction process, and this agreement is achieved through a mechanism called consensus. (
  • Instead - through consensus between actors on all sides - an informal, political process was agreed upon to lay the groundwork for a proper beginning to the democratic transition. (
  • Consensus is an inherent part of the wiki process. (
  • Occupy Wall Street (OWS) has given the consensus decision-making process a new lease on life by introducing the procedure to a new generation of organizers as well as thousands of older activists. (
  • I examine the historical development and the symbolic significance of consensus to suggest that process is a tension point that reveals significant differences in vision and strategy among sectors of the US Left. (
  • Philippine Ambassador to Singapore Antonio A. Morales believes that ASEAN's decision-making process by consensus is important in keeping the unity of the regional organization, which marks its golden jubilee this year. (
  • The "building capacity" consensus process. (
  • A formal consensus process was held and included an online survey and also a faceto- face meeting. (
  • Teleconferences and electronic-based discussions between the members of the committee subsequently served to discuss and develop the consensus process. (
  • In this article, we present a method to learn the interaction topology of a network of agents undergoing linear consensus updates in a non invasive manner. (
  • it is not uncommon to see both sides in an edit war claiming a consensus for its version of the article. (
  • The aim of this article is describing the applied methodology in the elaboration of this Latin-American Obesity Consensus, its contents and the governamental policies that are being developed to reduce the prevalence of obesity. (
  • Finally, we survey recent results including how to avoid well-known painpoints in permissionless consensus, and how to apply core ideas behind blockchains to solve consensus in the classical, permissioned setting and meanwhile achieve new properties that are not attained by classical approaches. (
  • Items considered less important according to predefined consensus criteria were dropped and a second survey was developed. (
  • A new consensus survey of expert opinions was published regarding the use of oral prostacyclin pathway agents in patients with various forms of pulmonary arterial hypertension (PAH) who received dual endothelin receptor antagonist (ERA)/phosphodiesterase type 5 inhibitor (PDE5i) therapy. (
  • I also consider why the Reagan-era antitrust consensus is currently vulnerable to displacement. (
  • A faculty webpage of the Department of Sociology and Anthropology at the University of North Carolina at Charlotte clarifies the differences between the consensus, interactionist and conflict views. (
  • With a deep understanding of the orthopedic industry, Consensus launched its innovative TracPatch Technology division focusing on orthopedic wearable technology, which combines Consensus Orthopedics 25 years of orthopedic experience with innovative Big Data capabilities. (
  • Hence, the purpose of this consensus document is to examine available data related to IOD, RVD, and alteration of the OVD. (
  • The long-discussed, highly controversial reservation of the names and acronyms of various intergovernmental and non-governmental organizations has become official ICANN Consensus Policy and will be binding on all gTLD registries and registrars from August this year. (
  • It's the 14th Consensus Policy to be added to ICANN's statute book since the organization was formed 20 year ago. (