General agreement or collective opinion; the judgment arrived at by most of those concerned.
A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.
Presentations of summary statements representing the majority agreement of physicians, scientists, and other professionals convening for the purpose of reaching a consensus--often with findings and recommendations--on a subject of interest. The Conference, consisting of participants representing the scientific and lay viewpoints, is a significant means of evaluating current medical thought and reflects the latest advances in research for the respective field being addressed.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
An iterative questionnaire designed to measure consensus among individual responses. In the classic Delphi approach, there is no interaction between responder and interviewer.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Articles on conferences sponsored by NIH presenting summary statements representing the majority agreement of physicians, scientists, and other professionals convening for the purpose of reaching a consensus on a subject of interest. This heading is used for NIH consensus conferences as a means of scientific communication. In indexing it is viewed as a type of review article and as a tag for any article appearing in any publication of the NIH Office of Medical Applications of Research (OMAR).
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Societies whose membership is limited to physicians.
Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
Nucleic acid sequences involved in regulating the expression of genes.
Established cell cultures that have the potential to propagate indefinitely.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes.
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
Proteins found in any species of bacterium.
Presentation of pertinent data by one with special skill or knowledge representing mastery of a particular subject.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
The relationships of groups of organisms as reflected by their genetic makeup.
Proteins prepared by recombinant DNA technology.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
The functional hereditary units of BACTERIA.
A systematic statement of policy rules or principles. Guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by convening expert panels. The text may be cursive or in outline form but is generally a comprehensive guide to problems and approaches in any field of activity. For guidelines in the field of health care and clinical medicine, PRACTICE GUIDELINES AS TOPIC is available.
Any method used for determining the location of and relative distances between genes on a chromosome.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
A group of deoxyribonucleotides (up to 12) in which the phosphate residues of each deoxyribonucleotide act as bridges in forming diester linkages between the deoxyribose moieties.
Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.
Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promoter and enhancer regions.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Deletion of sequences of nucleic acids from the genetic material of an individual.
Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.
Sequential operating programs and data which instruct the functioning of a digital computer.
The ultimate exclusion of nonsense sequences or intervening sequences (introns) before the final RNA transcript is sent to the cytoplasm.
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
A family of transcription factors that share an N-terminal HELIX-TURN-HELIX MOTIF and bind INTERFERON-inducible promoters to control GENE expression. IRF proteins bind specific DNA sequences such as interferon-stimulated response elements, interferon regulatory elements, and the interferon consensus sequence.
A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Biochemical identification of mutational changes in a nucleotide sequence.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Transport proteins that carry specific substances in the blood or across cell membranes.
The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.
Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.
An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.
Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Deoxyribonucleic acid that makes up the genetic material of viruses.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
Elements of limited time intervals, contributing to particular results or situations.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.
An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.
A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information.
The rate dynamics in chemical or physical systems.
Deoxyribonucleic acid that makes up the genetic material of fungi.
The quality or state of relating to or affecting two or more nations. (After Merriam-Webster Collegiate Dictionary, 10th ed)
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)
A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.
A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Recommendations for directing health planning functions and policies. These may be mandated by PL93-641 and issued by the Department of Health and Human Services for use by state and local planning agencies.
Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
A conserved A-T rich sequence which is contained in promoters for RNA polymerase II. The segment is seven base pairs long and the nucleotides most commonly found are TATAAAA.
A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
Genotypic differences observed among individuals in a population.
A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
The field which deals with illustrative clarification of biomedical concepts, as in the use of diagrams and drawings. The illustration may be produced by hand, photography, computer, or other electronic or mechanical methods.
A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.
A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
The functional hereditary units of FUNGI.
Proteins found in any species of fungus.
A form of GENE LIBRARY containing the complete DNA sequences present in the genome of a given organism. It contrasts with a cDNA library which contains only sequences utilized in protein coding (lacking introns).
Proteins found in any species of virus.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Two-dimensional separation and analysis of nucleotides.
Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
A sequential pattern of amino acids occurring more than once in the same protein sequence.
A subspecialty of medical oncology and radiology concerned with the radiotherapy of cancer.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
The administration of nutrients for assimilation and utilization by a patient by means other than normal eating. It does not include FLUID THERAPY which normalizes body fluids to restore WATER-ELECTROLYTE BALANCE.
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
The first nucleotide of a transcribed DNA sequence where RNA polymerase (DNA-DIRECTED RNA POLYMERASE) begins synthesizing the RNA transcript.
Nucleotide sequences located at the ends of EXONS and recognized in pre-messenger RNA by SPLICEOSOMES. They are joined during the RNA SPLICING reaction, forming the junctions between exons.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.
A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.
Proteins obtained from ESCHERICHIA COLI.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
RNA transcripts of the DNA that are in some unfinished stage of post-transcriptional processing (RNA PROCESSING, POST-TRANSCRIPTIONAL) required for function. RNA precursors may undergo several steps of RNA SPLICING during which the phosphodiester bonds at exon-intron boundaries are cleaved and the introns are excised. Consequently a new bond is formed between the ends of the exons. Resulting mature RNAs can then be used; for example, mature mRNA (RNA, MESSENGER) is used as a template for protein production.
The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.
A broad approach to appropriate coordination of the entire disease treatment process that often involves shifting away from more expensive inpatient and acute care to areas such as preventive medicine, patient counseling and education, and outpatient care. This concept includes implications of appropriate versus inappropriate therapy on the overall cost and clinical outcome of a particular disease. (From Hosp Pharm 1995 Jul;30(7):596)
The sequence at the 5' end of the messenger RNA that does not code for product. This sequence contains the ribosome binding site and other transcription and translation regulating sequences.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
Patterns of practice related to diagnosis and treatment as especially influenced by cost of the service requested and provided.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.
In eukaryotes, a genetic unit consisting of a noncontiguous group of genes under the control of a single regulator gene. In bacteria, regulons are global regulatory systems involved in the interplay of pleiotropic regulatory domains and consist of several OPERONS.
Ribonucleic acid that makes up the genetic material of viruses.
Conformity in fulfilling or following official, recognized, or institutional requirements, guidelines, recommendations, protocols, pathways, or other standards.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.
Activities and programs intended to assure or improve the quality of care in either a defined medical setting or a program. The concept includes the assessment or evaluation of the quality of care; identification of problems or shortcomings in the delivery of care; designing activities to overcome these deficiencies; and follow-up monitoring to ensure effectiveness of corrective steps.
Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).
Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.
Published materials which provide an examination of recent or current literature. Review articles can cover a wide range of subject matter at various levels of completeness and comprehensiveness based on analyses of literature that may include research findings. The review may reflect the state of the art. It also includes reviews as a literary form.
A protein which is a subunit of RNA polymerase. It effects initiation of specific RNA chains from DNA.
Research that involves the application of the natural sciences, especially biology and physiology, to medicine.

Ethical considerations in international HIV vaccine trials: summary of a consultative process conducted by the Joint United Nations Programme on HIV/AIDS (UNAIDS). (1/739)

Research that is initiated, designed or funded by sponsor agencies based in countries with relatively high social and economic development, and conducted in countries that are relatively less developed, gives rise to many important ethical challenges. Although clinical trials of HIV vaccines began ten years ago in the US and Europe, an increasing number of trials are now being conducted or planned in other countries, including several that are considered "developing" countries. Safeguarding the rights and welfare of individuals participating as research subjects in developing countries is a priority. In September, 1997, the Joint United Nations Programme on HIV/AIDS (UNAIDS) embarked on a process of international consultation; its purpose was further to define the important ethical issues and to formulate guidance that might facilitate the ethical design and conduct of HIV vaccine trials in international contexts. This paper summarises the major outcomes of the UNAIDS consultative process.  (+info)

Clinical ethics committees and the formulation of health care policy. (2/739)

For some time, clinical ethics committees (CECs) have been a prominent feature of hospitals in North America. Such committees are less common in the United Kingdom and Europe. Focusing on the UK, this paper evaluates why CECs have taken so long to evolve and assesses the roles that they should play in health care policy and clinical decision making. Substantive and procedural moral issues in medicine are differentiated, the former concerning ethicolegal principles and their paradigmatic application to clinical practice and the latter dealing with how such application should be negotiated in the face of disagreement and/or uncertainty. It will be argued that the role of CECs is both substantive and procedural. Provided that they do not overstep their appropriate moral and professional boundaries, CECs will be shown to have an important and positive function in improving hospital care within the UK and elsewhere.  (+info)

Quality and methods of developing practice guidelines. (3/739)

BACKGROUND: It is not known whether there are differences in the quality and recommendations between evidence-based (EB) and consensus-based (CB) guidelines. We used breast cancer guidelines as a case study to assess for these differences. METHODS: Five different instruments to evaluate the quality of guidelines were identified by a literature search. We also searched MEDLINE and the Internet to locate 8 breast cancer guidelines. These guidelines were classified in three categories: evidence based, consensus based and consensus based with no explicit consideration of evidence (CB-EB). Each guideline was evaluated by three of the authors using each of the instruments. For each guideline we assessed the agreement among 14 decision points which were selected from the NCCN (National Cancer Comprehensive Network) guidelines algorithm. For each decision point we recorded the level of the quality of the information used to support it. A regression analysis was performed to assess if the percentage of high quality evidence used in the guidelines development was related to the overall quality of the guidelines. RESULTS: Three guidelines were classified as EB, three as CB-EB and two as CB. The EB guidelines scored better than CB, with the CB-EB scoring in the middle among all instruments for guidelines quality assessment. No major disagreement in recommendations was detected among the guidelines regardless of the method used for development, but the EB guidelines had a better agreement with the benchmark guideline for any decision point. When the source of evidence used to support decision were of high quality, we found a higher level of full agreement among the guidelines' recommendations. Up to 94% of variation in the quality score among guidelines could be explained by the quality of evidence used for guidelines development. CONCLUSION: EB guidelines have a better quality than CB guidelines and CB-EB guidelines. Explicit use of high quality evidence can lead to a better agreement among recommendations. However, no major disagreement among guidelines was noted regardless of the method for their development.  (+info)

Inter-rater agreement in the scoring of abstracts submitted to a primary care research conference. (4/739)

BACKGROUND: Checklists for peer review aim to guide referees when assessing the quality of papers, but little evidence exists on the extent to which referees agree when evaluating the same paper. The aim of this study was to investigate agreement on dimensions of a checklist between two referees when evaluating abstracts submitted for a primary care conference. METHODS: Anonymised abstracts were scored using a structured assessment comprising seven categories. Between one (poor) and four (excellent) marks were awarded for each category, giving a maximum possible score of 28 marks. Every abstract was assessed independently by two referees and agreement measured using intraclass correlation coefficients. Mean total scores of abstracts accepted and rejected for the meeting were compared using an unpaired t test. RESULTS: Of 52 abstracts, agreement between reviewers was greater for three components relating to study design (adjusted intraclass correlation coefficients 0.40 to 0.45) compared to four components relating to more subjective elements such as the importance of the study and likelihood of provoking discussion (0.01 to 0.25). Mean score for accepted abstracts was significantly greater than those that were rejected (17.4 versus 14.6, 95% CI for difference 1.3 to 4.1, p = 0.0003). CONCLUSIONS: The findings suggest that inclusion of subjective components in a review checklist may result in greater disagreement between reviewers. However in terms of overall quality scores, abstracts accepted for the meeting were rated significantly higher than those that were rejected.  (+info)

Priority setting for new technologies in medicine: a transdisciplinary study. (5/739)

BACKGROUND: Decision makers in health care organizations struggle with how to set priorities for new technologies in medicine. Traditional approaches to priority setting for new technologies in medicine are insufficient and there is no widely accepted model that can guide decision makers. DISCUSSION: Daniels and Sabin have developed an ethically based account about how priority setting decisions should be made. We have developed an empirically based account of how priority setting decisions are made. In this paper, we integrate these two accounts into a transdisciplinary model of priority setting for new technologies in medicine that is both ethically and empirically based. SUMMARY: We have developed a transdisciplinary model of priority setting that provides guidance to decision makers that they can operationalize to help address priority setting problems in their institution.  (+info)

Consensus guidelines on analgesia and sedation in dying intensive care unit patients. (6/739)

BACKGROUND: Intensivists must provide enough analgesia and sedation to ensure dying patients receive good palliative care. However, if it is perceived that too much is given, they risk prosecution for committing euthanasia. The goal of this study is to develop consensus guidelines on analgesia and sedation in dying intensive care unit patients that help distinguish palliative care from euthanasia. METHODS: Using the Delphi technique, panelists rated levels of agreement with statements describing how analgesics and sedatives should be given to dying ICU patients and how palliative care should be distinguished from euthanasia. Participants were drawn from 3 panels: 1) Canadian Academic Adult Intensive Care Fellowship program directors and Intensive Care division chiefs (N = 9); 2) Deputy chief provincial coroners (N = 5); 3) Validation panel of Intensivists attending the Canadian Critical Care Trials Group meeting (N = 12). RESULTS: After three Delphi rounds, consensus was achieved on 16 statements encompassing the role of palliative care in the intensive care unit, the management of pain and suffering, current areas of controversy, and ways of improving palliative care in the ICU. CONCLUSION: Consensus guidelines were developed to guide the administration of analgesics and sedatives to dying ICU patients and to help distinguish palliative care from euthanasia.  (+info)

Development of the Knee Standardized Clinical Interview: a research tool for studying the primary care clinical epidemiology of knee problems in older adults. (7/739)

OBJECTIVE: To develop a standardized clinical interview, incorporating the perspectives of general practitioners (GPs) and rheumatologists, for primary care clinical epidemiological studies of adults aged 50 yr and over with knee problems. METHODS: Two parallel, consensus development studies using a modified nominal group technique involving GPs (n=5) and consultant rheumatologists (n=4) from North Staffordshire with reference panels of GPs (n=28) and rheumatologists (n=11) from selected centres in Great Britain, respectively. A single standardized clinical interview was formed using the clinical history questions identified in the consensus development studies and its feasibility was tested in a small sample of patients. RESULTS: In the GP consensus development study, 115 clinical history questions were identified, of which 71 were of agreed importance following postal rating, face-to-face discussion and re-rating. In the rheumatologist study, 158 questions were identified, of which 47 were of agreed importance. There was considerable overlap in the clinical history questions independently developed by the two studies. A single standardized clinical interview containing 74 questions was formed. It contained questions on the history, onset and recent course of the complaint; nature, location and severity of current knee symptoms; impact of knee problem; past history of knee problems; family history; comorbidity; previous/current investigations and treatment; ideas, concerns and expectations. In preliminary testing it took 20-45 min to conduct and was comprehensible to patients. CONCLUSIONS: A research tool-the Knee Standardized Clinical Interview (KNE-SCI)-has been formed from consensus development studies involving GPs and rheumatologists. In preliminary testing, it is comprehensible to patients, and forms a coherent clinical interview for research data collection. However, further evaluation is required to determine its accuracy and reliability and its usefulness for clinical epidemiological research.  (+info)

Building consensus on nomenclature and disease classification for ankylosing spondylitis: results and discussion of a questionnaire prepared for the International Workshop on New Treatment Strategies in Ankylosing Spondylitis, Berlin, Germany, 18-19 January 2002. (8/739)

BACKGROUND: There is currently no universal consensus on nomenclature for spondyloarthropathy (SpA), or on activity and severity criteria for ankylosing spondylitis (AS). METHOD: Points of agreement and majority opinions among 28 international experts in the field were identified by questionnaire. Agreement was defined as >80% concurrence, clear majority as >60% concurrence, and a majority or trend as >50% concurrence. RESULTS: Respondents agreed on the need for one term that reflects the inflammatory nature of the disease, but no agreement was reached on a specific term. Agreement included subdivision of patients with SpA into AS, psoriatic arthritis, inflammatory bowel disease associated arthritis, and undifferentiated spondyloarthritis/spondyloarthropathy. A majority of experts defined active disease as fulfilling classification criteria for AS and/or a SpA, and disease activity measured by a Bath AS Disease Activity Index (BASDAI) score >4 determined by two patient visits during a two month period, but no maximum radiographic score. The majority of participants considered failure of treatment response to non-steroidal anti-inflammatory drugs (NSAIDs) alone to be a prerequisite for active/severe AS, and 15/28 (54%) thought that NSAID treatment failure should be defined as lack of response to two or more NSAIDs. CONCLUSIONS: Respondents agreed that a two to five year study is the ethical method to demonstrate effects of anti-tumour necrosis factor alpha (TNFalpha) therapy on radiographic progression of AS, and that inclusion criteria should include a certain level of disease activity (measured by BASDAI) and failure of certain treatments. After the efficacy of anti-TNFalpha therapy in AS and psoriatic arthritis is proved, respondents agreed that more studies will be needed to show efficacy for other SpA subsets.  (+info)

November 6, 2008 - Lantheus Medical Imaging Inc. welcomes the Consensus Statement on the Clinical Applications of Ultrasound Contrast released by the American Society of Echocardiography (ASE) published in the November issue of the Journal of the American Society of Echocardiography.. Developed by members of the U.S. echocardiography community, ASEs consensus statement outlines when and how ultrasound contrast agents are to be used appropriately and efficiently to enhance the diagnostic capability of echocardiography.. We applaud the American Society of Echocardiography for its leadership in addressing the effective use of contrast ultrasound by authoring the Contrast Consensus Statement guidance document for the echocardiography community. This important consensus statement speaks to the clinical relevance of contrast and guides clinicians towards a team-approach to care for effective contrast use, said Don Kiepert, president and CEO, Lantheus Medical Imaging. The release of this ...
Lopez-Olivo, M. A., Kallen, M. A., Ortiz, Z., Skidmore, B. and Suarez-Almazor, M. E. (2008), Quality appraisal of clinical practice guidelines and consensus statements on the use of biologic agents in rheumatoid arthritis: A systematic review. Arthritis & Rheumatism, 59: 1625-1638. doi: 10.1002/art.24207 ...
Validation of non-invasive central blood pressure devices: ARTERY Society task force consensus statement on protocol standardization
AbstractThe burden of peripheral artery disease (PAD) and diabetes in Asia is projected to increase. Asia also has the highest incidence and prevalence of end-stage renal disease (ESRD) in the world. Therefore, most Asian patients with PAD might have diabetic PAD or ESRD-related PAD. Given these pandemic conditions, critical limb ischemia (CLI) with diabetes or ESRD, the most advanced and challenging subset of PAD, is an emerging public health issue in Asian countries. Given that diabetic and ESRD-related CLI have complex pathophysiology that involve arterial insufficiency, bacterial infection, neuropathy, and foot deformity, a coordinated approach that involves endovascular therapy and wound care is vital. Recently, there is increasing interaction among cardiologists, vascular surgeons, radiologists, orthopedic surgeons, and plastic surgeons beyond specialty and country boundaries in Asia. This article is intended to share practical Asian multidisciplinary consensus statement on the ...
TY - JOUR. T1 - Conclusions. T2 - A consensus statement on growth hormone therapy. AU - Rosenfeld, R.. AU - Hochberg, Z.. AU - Albertsson-Wikland, K.. AU - Gluckman, P. D.. AU - Kastrup, K.. AU - Kauli, R.. AU - Pescovitz, O. H.. AU - Price, D. A.. AU - Ranke, M. B.. AU - Rappaport, R.. AU - Reiter, E. O.. AU - Saenger, P.. AU - Vanderschueren-Lodeweyckx, M.. AU - Van-Wyk, J. J.. AU - Werther, G. A.. AU - Zadik, Z.. AU - Zachmann, M.. PY - 1990/1/1. Y1 - 1990/1/1. UR - http://www.scopus.com/inward/record.url?scp=0025298296&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0025298296&partnerID=8YFLogxK. M3 - Article. C2 - 2220383. AN - SCOPUS:0025298296. VL - 79. SP - 177. EP - 178. JO - Acta Paediatrica Scandinavica, Supplement. JF - Acta Paediatrica Scandinavica, Supplement. SN - 0300-8843. IS - 367. ER - ...
Despite numerous guidelines on the management of anaemia in surgical patients, there is no pragmatic guidance for the diagnosis and management of anaemia and iron deficiency in the postoperative period. A number of experienced researchers and clinicians took part in a two-day expert workshop and developed the following consensus statement. After presentation of our own research data and local policies and procedures, appropriate relevant literature was reviewed and discussed. We developed a series of best-practice and evidence-based statements to advise on patient care with respect to anaemia and iron deficiency in the postoperative period. These statements include: a diagnostic approach to iron deficiency and anaemia in surgical patients; identification of patients appropriate for treatment; and advice on practical management and follow-up that is easy to implement. Available data allow the fulfilment of the requirements of Pillar 1 of Patient Blood Management. We urge national and ...
The two- and one-half-day conference brought together experts in the field of relevant medical research and health care as well as representatives from the public. After listening to presentations and audience discussion at the conference, the panel, chaired by David J. Kupfer, M.D., Western Psychiatric Institute and Clinic, University of Pittsburgh, Pa., developed the statement.. The consensus statement can be found on the NIH Web site at http://odp.od.nih.gov/consensus/. The document can also be obtained from the NIH Consensus Program Information Center, P.O. Box 2577, Kensington, MD 20891; telephone: 888-644-2667.. ADHD is noted in the report to be the most commonly diagnosed behavioral disorder in childhood and represents a major public health problem. It is estimated that it affects 3 to 5 percent of all school-age children.. The report emphasizes that the impact of ADHD on the individuals with this disorder, their families and society is great. Children with ADHD cannot sit still and pay ...
This is a page with useful consensus documents and standards for people interested in clinical flow cytometry. The standards are listed in alphabetical order . If we are missing something, please feel free to contribute by adding it here. 2006 Bethesda International Consensus Recommendations on Immunophenotypic Analysis of Hematolymphoid Neoplasia by Flow Cytometry. Cytometry Part B, 2007. 2006 Bethesda International Consensus Recommendations on the Immunophenotypic Analysis of Hematolymphoid Neoplasia by Flow Cytometry: Recommendations for Training and Education to Perform Clinical Flow Cytometry, Cytometry Part B 2007 Clinical Flow Cytometric Analysis of Hematolymphoid Cells; Approved Guideline - Second Edition H43-A2 Clinical and Laboratory Standards Institute (CLSI) 2007 Enumeration of Immunologically Defined Cell Populations by Flow Cytometry; Approved Guideline-Second Edition H42-A2 Clinical and Laboratory Standards Institute (CLSI) 2007. MMWR 2003: Guidelines for Performing ...
A study contrasting the CDC Fukuda case definition with the International Consensus Criteria (ICC) for ME finds the ICC selects for a more physicall
A consensus statement is a comprehensive analysis by a panel of experts (i.e., consensus panel) of a scientific or medical issue related to diabetes. A consensus statement is developed immediately after a consensus conference at which presentations are made on the issue under review. The statement represents the panels collective analysis, evaluation, and opinion based, in part, on the conference proceedings. The need for a consensus statement arises when clinicians or scientists desire guidance on a subject for which there is a relative deficiency of comprehensive evidence that might otherwise allow for a more definitive statement to be made.. Consensus statements are published in American Diabetes Association journals and other scientific/medical journals, as appropriate. Once written by the panel, a consensus statement is not subject to subsequent review or approval and does not represent official association opinion. Listed below are recent consensus statements.. Postprandial Blood Glucose ...
An international consensus document on acellular matrix products in the treatment of hard-to-heal wounds such as diabetic foot ulcers, venous leg ulcers and pressure ulcers. Currently there is no definitive paper or guideline on the use of acellular matrices in acute and chronic wounds. To.... ...
Objectives: The aim of the present publication was to report on the EAO Workshop group-4 discussions and consensus statements on the five reviews previously prepared. These reviews provided the scientific evidence on the effect of crown-to-implant ratio, on reconstructions with cantilevers in fully and partially edentulous patients, on biological and technical complications of tilted in comparison with straight implants, and on the effects of osseointegrated implants functioning in a residual dentition. Material and Methods: The group discussed, evaluated, corrected where deemed appropriate, and made recommendations to the authors regarding the following five reviews submitted: (a) Is there an effect of crown-to-implant ratio on implant treatment outcomes?; (b) Implant-supported cantilevered fixed dental rehabilitations in fully edentulous patients; (c) and in partially edentulous patients; (d) Biological and technical complications of tilted implants in comparison with straight implants ...
The National Consensus Statement: Essential elements for safe and high-quality end-of-life care (the Consensus Statement) was endorsed by Australian Health Ministers in May 2015.. Clinicians, health service executives and managers, policy-makers, educators and training providers can use the principles and ten essential elements of the Consensus Statement as a guide to improving the safety and quality of end-of-life care.. The consensus statement was developed in partnership with health consumers and carers, experts in the field, representatives from public and private hospitals and health services, professional colleges, state and territory health departments, and other government health agencies. Please contact the Commission if you would like more details on the consultation process.. Preliminary scoping work undertaken prior to developing the consensus statement is summarised in Safety and Quality of End-of-Life Care in Acute Hospitals: A Background Paper. This paper presents a précis of the ...
Though recently bolstered by the results of the PIONEER AF-PCI trial, the evidence base on how to manage antithrombotic therapy in patients with A-fib undergoing PCI remains limited and clinical uncertainty abounds. Now, an updated North American consensus document aims to provide some guidance to clinicians wondering what to do with this hard-to-treat population.. Since the last iteration of the document was published in 2011, new evidence regarding the management of antiplatelet and anticoagulant therapies in patients requiring both has emerged in the form of the WOEST and ISAR-TRIPLE trials. PIONEER AF-PCI provides even more information but was released too recently-just 2 weeks ago at the American Heart Association Scientific Sessions-to be incorporated into the new consensus document, which was published online November 1, 2016, ahead of print in Circulation: Cardiovascular Interventions and discussed during a presentation at TCT 2016.. Clinicians have little to go on when deciding how to ...
Most functional test procedures are based on closed skill tasks (eg, single or triple hop, T drill, figure 8 runs), but sport requires open skills in addition to closed skills. Open skills have a reactive element to execute the motor task, usually in addition to decision-making, often in a fatigued state. Therefore, relying on closed skill tasks alone in determining readiness to RTS is not optimal. Gradual and sequential introduction of sport-specific training can be used as functional tests that include an element of protected reactive decision-making (ideally context specific).19-21 Any battery of tests assessing the athletes readiness to RTS should consider both open and closed skills, although in some clinical contexts this may be difficult because of factors including time, space and resources. If this is the case, assessment of closed skills in conjunction with other impairment-based and functional parameters gives the clinician and the athlete a minimum level of information for RTS ...
Lateral ankle sprains (LASs) are the most prevalent musculoskeletal injury in physically active populations. They also have a high prevalence in the general population and pose a substantial healthcare burden. The recurrence rates of LASs are high, leading to a large percentage of patients with LAS …
Paul Kidd from the HIV Legal Working Group (VAC and Positive Life VIC) launched a recently published consensus statement about HIV and the law at the ASHM hub during the afternoon break on Wednesday. The consensus statement was written by leading HIV
For the present, TNF blockade should be reserved for patients with RA whose symptoms and signs are resistant to disease modifying antirheumatic drug (DMARD) treatment. It is generally agreed that all patients with active disease should be treated with DMARDs, as such treatment ameliorates symptoms and slows progression of structural damage.2 However, long term efficacy of DMARDs is limited and toxicity accumulates.3 Currently, two TNF-blocking agents, etanercept and infliximab, have received regulatory authority approval for the treatment of RA. Both compounds, alone or in combination with methotrexate, have proved to be successful in significantly reducing inflammatory activity and increasing the quality of life.4-8 In addition, infliximab in combination with methotrexate has been shown to arrest radiographic progression over one year in up to 50% of patients,9 while etanercept has been shown to retard radiographic progression significantly in DMARD-naive patients.10 Nevertheless, in early RA, ...
Future progress on understanding and treating infections caused by equine herpesvirus-1 will depend on research into viral pathogenesis
Thank you for your interest in spreading the word about Diabetes Care.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
The Team Physician Consensus Conference is a project-based alliance. The group meets annually to produce a consensus statement, which is a blend of evidence-based research and expert consensus.
This cohort study uses health system and research cohort data to compare the ability of existing vs new clinical criteria for sepsis to identify intensive care
There is no consensus on the pathologic conditions or severity implied by the term hippocampal sclerosis (HS). In this study, a panel of experienced neuropathologists evaluated inter-rater agreement for pathologic diagnoses in the hippocampus and proposes consensus recommendations on the use of the term HS. In a group of 251 cases of HS selected from a large autopsy cohort (1,388; 18%), a coordinating group identified 5 patterns of degenerative or vascular pathology. Four independent neuropathologists assessed a single set of hematoxylin and eosin-stained sections following descriptive definitions to classify the appearances and assign the diagnosis of HS, if appropriate. Diagnostic agreement (range, 36%-70%) was highest for vascular lesions. Subsequent joint review of all cases highlighted the need to identify neurodegenerative lesions using immunohistochemistry. Initial agreement in assigning the diagnosis of HS varied from 0% to 86%. After a joint review, the group recommended that the ...
A recent study suggests that while the ICC does select for more ME/CFS-like patients it also selects for patients with more psychiatric disorders.
The European Association for the Study of Diabetes (EASD) and the American Diabetes Association (ADA) have produced an updated consensus statement on
Stamatakis and colleagues from University College present comprehensive data about overweight and obesity trends from 1974 to 2003 in English children. The data are disturbing, but not surprising. They mimic information from many other countries. For example, the rates of obesity for boys aged 5-7 years increased from 1.0% in 1974 to 5.2% in 2002-03. For obesity, there was a five to six fold increase for all groups (boys and girls aged 5-7 and 8-10 years), and a near doubling in the prevalence of overweight children (18.5% to 27.1%). Sadly, the rate of change was substantially greater between 2000-01 and 2002-03 than between 1974 and 2000. In a companion perspective, Rudolf, Hochberg, and Speiser describe the conclusions of a recent International Consensus Statement on childhood obesity. The statement addresses definition, preventive strategies, screening, assessment, and treatment. The authors discuss the implications of this statement for the UK.. A recent brouhaha occurred in the US with ...
Leading Diabetes Organizations Issue Consensus Statement Defining Health Outcomes beyond HbA1c --The Type 1 Diabetes Outcomes Program, organized by JDRF, has identified and defined clinically meaningful
The link below is to the 2015 Consensus document about BCG and alternatives. Consensus statement on best practice management regarding the use of intravesical...
Orlandi RR, Kingdom TT, Hwang PH, Smith TL, Alt JA, Baroody FM, Batra PS, Bernal-Sprekelsen M, Bhattacharyya N, Chandra RK, Chiu A, Citardi MJ, Cohen NA, DelGaudio J, Desrosiers M, Dhong HJ, Douglas R, Ferguson B, Fokkens WJ, Georgalas C, Goldberg A, Gosepath J, Hamilos DL, Han JK, Harvey R, Hellings P, Hopkins C, Jankowski R, Javer AR, Kern R, Kountakis S, Kowalski ML, Lane A, Lanza DC, Lebowitz R, Lee HM, Lin SY, Lund V, Luong A, Mann W, Marple BF, McMains KC, Metson R, Naclerio R, Nayak JV, Otori N, Palmer JN, Parikh SR, Passali D, Peters A, Piccirillo J, Poetker DM, Psaltis AJ, Ramadan HH, Ramakrishnan VR, Riechelmann H, Roh HJ, Rudmik L, Sacks R, Schlosser RJ, Senior BA, Sindwani R, Stankiewicz JA, Stewart M, Tan BK, Toskala E, Voegels R, Wang de Y, Weitzel EK, Wise S, Woodworth BA, Wormald PJ, Wright ED, Zhou B, Kennedy DW. International Consensus Statement on Allergy and Rhinology: Rhinosinusitis. Int Forum Allergy Rhinol. 2016 Feb; 6 Suppl 1:S22-209. PMID: 26889651. ...
Management of anaemia and iron deficiency in patients with cancer • Management of infusion reactions to systemic anticancer therapy • Management of toxicities from immunotherapy • Management of febrile neutropaenia • MASCC and ESMO consensus guidelines for the prevention of chemotherapy and radiotherapy-induced nausea and vomiting • Treatment of dyspnoea in advanced cancer patients • Central venous access in oncology • Management of oral and gastrointestinal mucosal injury • Management of refractory symptoms at the end of life and the use of palliative sedation • Advanced care planning in palliative care • Bone health in cancer patients • Cancer, fertility and pregnancy • Management of chemotherapy extravasation • Cardiovascular toxicity induced by chemotherapy, targeted agents and radiotherapy • Management of cancer pain • Management of venous thromboembolism in cancer patients. ...
What should be the recommendations regarding the type (IV versus PO) and length of postoperative antibiotic treatment when a one-stage revision arthroplasty is performed for subacute/chronic shoulder PJI of the shoulder caused by an indolent organism (P. acnes, coag neg staph spec ...
What is the optimal management (Masquelet technique, bone transfer) of post-infective bone defects in different long bones (tibia, femur, humerus etc.)? How does this vary by type of defect (conical vs. cylindrical ...
Since the 2001 update of the American Heart Association (AHA)/American College of Cardiology (ACC) consensus statement on secondary prevention,1 important evidence from clinical trials has emerged that further supports and broadens the merits of aggressive risk-reduction therapies for patients with established coronary and other atherosclerotic vascular disease, including peripheral arterial disease, atherosclerotic aortic disease, and carotid artery disease. This growing body of evidence confirms that aggressive comprehensive risk factor management improves survival, reduces recurrent events and the need for interventional procedures, and improves quality of life for these patients.. Compelling evidence from recent clinical trials and revised practice guidelines provided the impetus for this update of the 2001 recommendations with evidence-based results (Table 1⇓). Classification of Recommendations and Level of Evidence are expressed in ACC/AHA format, as detailed in Tables 2 and 3⇓. ...
1996 - CDC, ACOG, and AAP publish the first consensus statement on GBS National Prevention Guidelines, June - GBSA publishes new patient education pamphlet based on new medical guidelines - Vaccine Officers prepare for first widespread clinical trials of GBS vaccine - GBSA expands National Medical Advisory Board to include researchers on adult GBS - GBSA has twelve State Medical Advisory Boards - GBSI (Group B Strep Initiative) Vaccine researchers enter last year of five year NIH (National Institutes of Health) grant - GBSA awarded $10,000 grant to work with CDC on GBS awareness among medical professionals working with at-risk African American women in inner city Atlanta ...
Nicole Artz, MD, a hospitalist and Assistant Professor of Medicine at the University of Chicago Hospital, discusses implications of hyperglycemia in hospitalized patients. References and Resources ACE/ADA Task Force on Inpatient Diabetes. American College of Endocrinology and American Diabetes Association Consensus statement on inpatient...
BACKGROUND AND OBJECTIVES: There are no widely accepted criteria for the definition of hematopoietic stem cell transplant -associated microangiopathy (TAM). An International Working Group was formed to develop a consensus formulation of criteria for diagnosing clinically significant TAM. DESIGN AND METHODS: The participants proposed a list of candidate criteria, selected those considered necessary, and ranked those considered optional to identify a core set of criteria. Three obligatory criteria and four optional criteria that ranked highest formed a core set. In an appropriateness panel process, the participants scored the diagnosis of 16 patient profiles as appropriate or not appropriate for TAM. Using the experts ratings on the patient profiles as a gold standard, the sensitivity and specificity of 24 candidate definitions of the disorder developed from the core set of criteria were evaluated. A nominal group technique was used to facilitate consensus formation. The definition of TAM with ...
I am not aware of any robust epidemiology studies investigating the possible effects of GBH exposures on endocrine-related diseases such as cancer, IQ loss, thyroid hormone perturbations, and organ changes. As stated in the international scientists consensus statement on glyphosate and its formulations, there are large gaps in our knowledge about such effects and more studies need to be carried out. Of course the absence of such published research is not a sign that GBHs do not cause endocrine effects. We have the technology and the scientists to do such work - but the latter apparently lack financial support and/or are worried about industry criticism and intimidation if the results show that GBHs should be banned.. ...
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The gTLD Registries Stakeholder Group (RySG) is a recognized entity within the Generic Names Supporting Organization (GNSO) formed according to Article X, Section 5 (September 009) of the Internet Corporation for Assigned Names and Numbers (ICANN) Bylaws.. The primary role of the RySG is to represent the interests of gTLD registry operators (or sponsors in the case of sponsored gTLDs) (Registries) (i) that are currently under contract with ICANN to provide gTLD registry services in support of one or more gTLDs; (ii) who agree to be bound by consensus policies in that contract; and (iii) who voluntarily choose to be members of the RySG. The RySG may include Interest Groups as defined by Article IV. The RySG represents the views of the RySG to the GNSO Council and the ICANN Board of Directors with particular emphasis on ICANN consensus policies that relate to interoperability, technical reliability and stable operation of the Internet or domain name system.. The guiding principles for the RySG, ...
Participants: In April 2004, a panel of physicians convened in New York City to discuss recommendations for clinical management of and additional research on SRI discontinuation syndrome. Evidence: Previous guidance for management of SRI discontinuation syndrome was proposed in 1997 in a consensus meeting also chaired by Alan F. Schatzberg. A literature search of the PubMed database was conducted to identify articles on SRI discontinuation syndrome that have been published since 1997 ...
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This text was prepared by the Task Force for the Safety of Novel Foods and Feeds to provide an introduction to the consensus documents of the OECDs Task Force. It explains, amongst other things, why the Task Force decided to prepare consensus documents as part of its programme of work. It describes their purpose and their use as a practical contribution to the risk/safety assessment of foods and feeds derived from transgenic. ...
List of publications by the Neuro-MIG network (COST Action CA16118) from 2017 to present:Biallelic DAB1 Variants Are Associated With Mild Lissencephaly and Cerebellar Hypoplasia. Daphne J. Smits, Rachel Schot, Martina Wilke, Marjon van Slegtenhorst, Marie Claire Y. de Wit, Marjolein H.G. Dremmen, William B. Dobyns, A. James Barkovich, Grazia M.S. Mancini. Neurology April 2021;
Lively debate ensued regarding the merits and otherwise of these techniques. The need to be innovative and to review what could be done better was a common theme. There was consensus that all clinical trials should also be testing the various biomarkers currently available. There was acute awareness that over the next five years there could well be a therapy available for some types of ALS/MND and it will be vital to ensure people have access as early as possible in the disease process. For some people with the familial form a reliable and objective biomarker could pick up disease progression before the person experiences any symptoms ...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
EDITORIAL International Angiology 2012 August;31(4):307-9. New oral anticoagulant in atrial fibrillation: are they comparable?. Kalodiki E., Lewis B., Fareed J.. PDF. ORIGINAL ARTICLES International Angiology 2012 August;31(4):310-5. Meta-analysis of the impact of the principal venoactive drugs agents on malleolar venous edema. Allaert F. A.. Abstract PDF. ORIGINAL ARTICLES International Angiology 2012 August;31(4):316-29. Chronic edema of the lower extremities: international consensus recommendations for compression therapy clinical research trials. Stout N., Partsch H., Szolnoky G., Forner-Cordero I., Mosti G., Mortimer P., Flour M., Damstra R., Piller N., Geyer M. J., Benigni J. P., Moffat C., Cornu-Thenard A., Schingale F., Clark M., Chauveau M.. Abstract PDF. ORIGINAL ARTICLES International Angiology 2012 August;31(4):330-9. Comparison of efficacy and safety of dabigatran, rivaroxaban and apixaban in patients with atrial fibrillation using network meta-analysis. Harenberg J., Marx S., ...
The European Academy of Allergy and Clinical Immunology, EAACI, is an association including 47 European National Societies, more than 8,000 academicians, research investigators and clinicians.
May 5, 2011 (Updated August 1, 2011) - Genetic testing is increasingly important in determining potential cardiac conditions in patients and is used in clinical settings more than ever before. To ensure that physicians have up-to-date knowledge of the evolving role of genetic testing for sudden death predisposing, genetic heart diseases in cardiology, which can be life-saving for some patients, the Heart Rhythm Society and the European Heart Rhythm Association have prepared HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies. The consensus statement was released at Heart Rhythm 2011, the Heart Rhythm Societys 32nd Annual Scientific Sessions.
We have read with interest the consensus document on the use of the polypill1 and the editorial by González-Juanatey et al.2 The authors should be congratulated for their initiative in producing a document that helps to increase our knowledge of this therapy and, moreover, defines the situations in which its use can be beneficial. The European Society of Cardiology indicates that reducing the frequency of administration is the most effective way to improve treatment adherence, and it reportedly could reduce cardiovascular events by 75%. However, in our opinion, this document does not deal with an aspect that we consider of vital importance in secondary prevention. Both the consensus document and the editorial underline the need to control hypertension and cholesterol, stressing high-risk patients, but make no mention of patients with coronary stents. We feel that they should include some comment on this subject, especially concerning drug-eluting stents, therapeutic devices used in most ...
TY - JOUR. T1 - ISHLT consensus statement on donor organ acceptability and management in pediatric heart transplantation. AU - Kirk, Richard. AU - Dipchand, Anne I.. AU - Davies, Ryan R.. AU - Miera, Oliver. AU - Chapman, Gretchen. AU - Conway, Jennifer. AU - Denfield, Susan. AU - Gossett, Jeffrey G.. AU - Johnson, Jonathan. AU - McCulloch, Michael. AU - Schweiger, Martin. AU - Zimpfer, Daniel. AU - Ablonczy, László. AU - Adachi, Iki. AU - Albert, Dimpna. AU - Alexander, Peta. AU - Amdani, Shahnawaz. AU - Amodeo, Antonio. AU - Azeka, Estela. AU - Ballweg, Jean. AU - Beasley, Gary. AU - Böhmer, Jens. AU - Butler, Alison. AU - Camino, Manuela. AU - Castro, Javier. AU - Chen, Sharon. AU - Chrisant, Maryanne. AU - Christen, Urs. AU - Danziger-Isakov, Lara. AU - Das, Bibhuti. AU - Everitt, Melanie. AU - Feingold, Brian. AU - Fenton, Matthew. AU - Garcia-Guereta, Luis. AU - Godown, Justin. AU - Gupta, Dipankar. AU - Irving, Claire. AU - Joong, Anna. AU - Kemna, Mariska. AU - Khulbey, Sanjeev ...
There is a need for a clear definition of exacerbations used in clinical trials in patients with bronchiectasis. An expert conference was convened to develop a consensus definition of an exacerbation for use in clinical research.. A systematic review of exacerbation definitions used in clinical trials from January 2000 until December 2015 and involving adults with bronchiectasis was conducted. A Delphi process followed by a round-table meeting involving bronchiectasis experts was organised to reach a consensus definition. These experts came from Europe (representing the European Multicentre Bronchiectasis Research Collaboration), North America (representing the US Bronchiectasis Research Registry/COPD Foundation), Australasia and South Africa.. The definition was unanimously approved by the working group as: a person with bronchiectasis with a deterioration in three or more of the following key symptoms for at least 48 h: cough; sputum volume and/or consistency; sputum purulence; breathlessness ...
In a review of research papers published in the period 1966 to 2005, Pluim et al1 showed that reported incidences of tennis injuries ranged over two orders of magnitude (0.04 to 3 injuries/1000 player-hours). Although some of this variation can be accounted for by the different sample populations used in the studies, the authors stated that the main reason for the differences was more likely to be due to the variation in injury definitions and protocols employed in the studies. Consensus statements for cricket,2 football3 and rugby union4 have previously outlined the benefits associated with developing and implementing consistent definitions, data-collection procedures and methods of reporting results in injury surveillance studies. Although these consensus statements were specifically developed for team sports, the International Olympic Committee (IOC) and the International Association of Athletics Federations (IAAF) demonstrated that the principles were also relevant to individual sports.5 6 ...
While many studies have reported that providing parenteral nutrition (PN) can change nutritional outcomes, there are limited data that demonstrate that PN influences clinically-important end points in critically-ill patients. The purpose of the present paper is to systematically review and critically appraise the literature to examine the relationship between PN and morbidity and mortality in the critically-ill patient. Studies comparing enteral nutrition (EN) with PN and studies comparing PN with no PN were reviewed. The results suggest that EN is associated with reduced infectious complications in some critically-ill subgroups. PN, on the other hand, is associated with increased morbidity and mortality in critically-ill patients. When nutritional support is indicated, EN should be used preferentially over PN. Further studies are needed to define the optimal timing and composition of PN in patients not tolerating sufficient EN. Strategies to optimize EN delivery and minimize PN utilization in ...
Abbara S1, Blanke P2, Maroules CD, et al. SCCT guidelines for the performance and acquisition of coronary computed tomographic angiography: A report of the society of Cardiovascular Computed Tomography Guidelines Committee: Endorsed by the North American Society for Cardiovascular Imaging (NASCI). J Cardiovasc Comput Tomogr. 2016;10(6):435-449. PMID: 27780758 www.ncbi.nlm.nih.gov/pubmed/27780758. Abraham NS, Hlatky MA, Antman EM, et al. ACCF/ACG/AHA 2010 Expert Consensus Document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: a report of the American College of Cardiology Foundation Task Force on Expert Consensus Documents. Circulation. 2010;122(24):2619-2633. PMID: 21060077 www.ncbi.nlm.nih.gov/pubmed/21060077. Brilakis ES, Patel VG, Banerjee S. Medical management after coronary stent implantation: a review. JAMA. ...
TY - JOUR. T1 - Personalizing the treatment of women with early breast cancer. T2 - Highlights of the st gallen international expert consensus on the primary therapy of early breast Cancer 2013. AU - Goldhirsch, A.. AU - Winer, E. P.. AU - Coates, A. S.. AU - Gelber, R. D.. AU - Piccart-Gebhart, M.. AU - Thürlimann, B.. AU - Senn, H. J.. AU - Albain, Kathy S.. AU - André, Fabrice. AU - Bergh, Jonas. AU - Bonnefoi, Hervé. AU - Bretel-Morales, Denisse. AU - Burstein, Harold. AU - Cardoso, Fatima. AU - Castiglione-Gertsch, Monica. AU - Coates, Alan S.. AU - Colleoni, Marco. AU - Costa, Alberto. AU - Curigliano, Giuseppe. AU - Davidson, Nancy E.. AU - Leo, Angelo Di. AU - Ejlertsen, Bent. AU - Forbes, John F.. AU - Gelber, Richard D.. AU - Gnant, Michael. AU - Goldhirsch, Aron. AU - Goodwin, Pamela. AU - Goss, Paul E.. AU - Harris, Jay R.. AU - Hayes, Daniel F.. AU - Hudis, Clifford A.. AU - Ingle, James N.. AU - Jassem, Jacek. AU - Jiang, Zefei. AU - Karlsson, Per. AU - Loibl, Sibylle. AU - ...
Background/Aims: A large amount of new data on the treatment of chronic hepatitis B has become available such that the 2003 consensus statement requires revision and update.. Methods: New data were presented, discussed and debated in an expert pre-meeting to draft a revision. The revised contents were finalized after discussion in a general meeting of APASL.. Results: Conceptual background, including the efficacy and safety profile of currently available and emerging drugs, was reviewed. Nineteen recommendations were formed and unresolved issues and areas for further study were suggested.. Conclusion: The current therapy of chronic hepatitis B is modestly effective but not satisfactory. The development of new drugs and new strategies is required to further improve the outcomes of treatment. ...
Orthopedics Today reported that ankle surgeons around the world met at the International Consensus Meeting on Cartilage Repair of the Ankle, where they discussed the best ways to treat ankle cartilage injuries and established a consensus for all surgeons. John G. Kennedy, MD, foot and ankle surgeon at HSS and co-founder of the International Soc...
Welcome to Fats of Life. This is a hub for health on the benefits of EPA and DHA omega-3s intended only for medical practitioners.. If you are a patient researching omega-3s please visit our consumer website alwaysomega3s.com. ...
Welcome to Fats of Life. This is a hub for health on the benefits of EPA and DHA omega-3s intended only for medical practitioners.. If you are a patient researching omega-3s please visit our consumer website alwaysomega3s.com. ...
Key clinical point: A group of hematology specialists provided consensus statements on the evaluation of bleeding in patients with acquired hemophilia.Major finding: If expert hematologist consultation is not available, and the bleeding event is life‐threatening, the emergency physician should initiate treatment in accordance with local or national recommendations.Study details: Consensus recommendations provided by 36 global experts in acquired hemophilia.
The Delphi method is widely used in education as a technique to lead individual expert opinions to group consensus [22]. Although criticised within the literature for its lack of scientific merit [23], the Delphi method continues to be widely used as a valuable tool to establish guidelines, standards, policy documents and for predicting trends [24, 25]. Typically, the Delphi process comprises of a series of three rounds to 1) present the information and allow respondents the flexibility to elaborate on the content and make suggestions; 2) feed results back and present more specific information and 3) feed results back and give the respondent the opportunity to comment on why their opinion remains outside the consensus.. To apply the Delphi technique to the aims and objectives of creating standards for training content in postgraduate respiratory physiotherapy, three broad elements were considered in the design and presentation of this process:. 1. Nomination of the expert panel and number of ...
Ackerman MJ., Priori SG., Willems S., Berul C., Brugada R., Calkins H., Camm AJ., Ellinor PT., Gollob M., Hamilton R., Hershberger RE., Judge DP., Le Marec H., McKenna WJ., Schulze-Bahr E., Semsarian C., Towbin JA., Watkins H., Wilde A., Wolpert C., Zipes DP., Heart Rhythm Society (HRS) None., European Heart Rhythm Association (EHRA) None ...
Society for Translational Medicine expert consensus on training and certification standards for surgeons and assistants in minimally invasive surgery for lung cancer
Background:Women with autoimmune rheumatic diseases (ARDs) find it difficult to get information and support with family planning, pregnancy, and early parenting. A systematic approach to prioritising research is required to accelerate development and evaluation of interventions to meet the complex needs of this population. Methods:A Nominal Group Technique (NGT) exercise was carried out with lay and professional stakeholders (n=29). Stakeholders were prepared for debate through presentation of available evidence. Stakeholders completed three tasks to develop, individually rank, and reach consensus on research priorities: Task 1 - mapping challenges and services using visual timelines; Task 2 - identifying research topics; Task 3 - individually ranking research topics in priority order. Results of the ranking exercise were fed back to the group for comment. Results:The main themes emerging from Task 1 were the need for provision of information, multi-disciplinary care, and social and peer ...
Background/objectives: This paper is part of the international consensus guidelines on chronic pancreatitis, presenting for interventional endoscopy. Methods: An international working group with experts on interventional endoscopy evaluated 26 statements generated from evidence on 9 clinically relevant questions. The Grading of Recommendations Assessment, Development, and Evaluation approach was used to evaluate the level of evidence. To determine the level of agreement, a nine-point Likert scale was used for voting on the statements. Results: Strong consensus was obtained for 15 statements relating to nine questions including the recommendation that endoscopic intervention should be offered to patients with persistent severe pain but not to those without pain. Endoscopic decompression of the pancreatic duct could be used for immediate pain relief, and then offered surgery if this fails or needs repeated endoscopy. Endoscopic drainage is preferred for portal-splenic vein thrombosis and ...
WASHINGTON, D.C., and DALLAS (March 17, 2014) - The increasing number of percutaneous coronary interventions (PCIs) being performed at low-volume centers without on-site cardiac surgery backup has driven the need for new safety and quality protocols, according to an expert consensus document released today and written by a committee representing the Society for Cardiovascular Angiography and Interventions (SCAI), the American College of Cardiology Foundation (ACCF) and the American Heart Association (AHA). The document outlines steps hospitals can take to provide the safest possible environment for PCI when the facility does not provide cardiac surgery as a backup should complications occur.
Therefore, European Liver Patients Association (ELPA) invited leading psychologists, psychiatrists and hepatologists to an expert conference in 2011. Martin Schaefer MD and his colleagues reviewed the scientific data and discussed their experience in the treatment of hepatitis C related psychiatric problems. The results were first presented at the EASL conference in Berlin in 2011. Since the conference, the recommendations were refined and updated further to include the new antiviral treatments, and will now be published as a European Expert Consensus Statement in the Journal of Hepatology ...
These Expert Consensus Statements (ECS) were developed by the AAO-HNSF. ECS reflect opinions synthesized from an organized group of…
October 15, 2012 -- The European Society of Gastrointestinal and Abdominal Radiology (ESGAR) has published its first update on CT colonography (CTC) guidelines since 2007. Its working group on CTC has endorsed 86 statements, reaching near-complete agreement on 71 of the 86 items relating to critical practice areas affecting CTC.. Agreement was most consistent in the areas of colon distension, scan parameters, use of intravenous contrast agents, patient preparation, and the role of computer-aided detection (CAD) and lesion measurement. Less than unanimous accord was seen in the use of spasmolytics, decubitus positioning and the number of CT data acquisitions, fecal tagging, 2D versus 3D reading, and reporting.. Over the last five years, expansion of the CT colonography literature has continued and several important studies, including multicenter studies, have been published, wrote Dr. Emanuele Neri and colleagues from six EU countries on behalf of the ESGAR CTC working group. These new data ...
This is a clinical practice guideline on the appropriate use of immunotherapy for the treatment of patients with bladder cancer, specifically non-muscle invasive bladder cancer, muscle invasive bladder cancer, and advanced bladder cancer. The guideline addresses issues related to the definition of risk categories, patient selection, toxicity management, clinical endpoints, as well as the combination and sequencing of therapies. The guideline also highlights areas for future direction and development to advance the use of immunotherapy in bladder cancer treatment.. ...
TY - JOUR. T1 - International consensus on preliminary definitions of improvement in adult and juvenile myositis. AU - Rider, Lisa G.. AU - Giannini, Edward H.. AU - Brunner, Hermine I.. AU - Ruperto, Nicola. AU - James-Newton, Laura. AU - Reed, Ann M.. AU - Lachenbruch, Peter A.. AU - Miller, Frederick W.. PY - 2004/7. Y1 - 2004/7. N2 - Objective. To use a core set of outcome measures to develop preliminary definitions of improvement for adult and juvenile myositis as composite end points for therapeutic trials. Methods. Twenty-nine experts in the assessment of myositis achieved consensus on 102 adult and 102 juvenile paper patient profiles as clinically improved or not improved. Two hundred twenty-seven candidate definitions of improvement were developed using the experts consensus ratings as a gold standard and their judgment of clinically meaningful change in the core set of measures. Seventeen additional candidate definitions of improvement were developed from classification and regression ...
Make better use of current drugs and treat as soon as possible, says Dr Alexandre Mebazaa, lead author of new European recommendations on acute heart failure.
The main strategy for preventing VTE-related mortality is thromboprophylaxis, but guidance regarding its use differs across specialties and organizations. For this reason, the National Partnership for Maternal Safety (NPMS), a group made up of a variety of leaders in womens health care, has created a safety bundle to review current guidance and make recommendations regarding venous thromboembolism during pregnancy.
Patients suffering from cardiovascular autonomic failure often develop neurogenic supine hypertension (nSH), i.e., high blood pressure (BP) in the supine p
Roy Freeman;Wouter Wieling;Felicia Axelrod;David Benditt;Eduardo Benarroch;Italo Biaggioni;William Cheshire;Thomas Chelimsky;Pietro Cortelli;Christopher Gibbons;David Goldstein;Roger Hainsworth;Max Hilz;Giris Jacob;Horacio Kaufmann;Jens Jordan;Lewis Lipsitz;Benjamin Levine;Phillip Low;Christopher Mathias;Satish Raj;David Robertson;Paola Sandroni;Irwin Schatz;Ron Schondorff;Julian Stewart;Gert van Dijk; + Author Information ...
ADI aims to provide the public with an improved understanding of the benefits of implantology, and Members with the benefits of continuous skills development and safeguarding of standards.
TY - JOUR. T1 - OARSI recommendations for the management of hip and knee osteoarthritis, Part II. T2 - OARSI evidence-based, expert consensus guidelines. AU - Zhang, W.. AU - Moskowitz, R. W.. AU - Nuki, G.. AU - Abramson, S.. AU - Altman, R. D.. AU - Arden, N.. AU - Bierma-Zeinstra, S.. AU - Brandt, K. D.. AU - Croft, P.. AU - Doherty, M.. AU - Dougados, M.. AU - Hochberg, M.. AU - Hunter, D. J.. AU - Kwoh, K.. AU - Lohmander, L. S.. AU - Tugwell, P.. PY - 2008/2. Y1 - 2008/2. N2 - Purpose: To develop concise, patient-focussed, up to date, evidence-based, expert consensus recommendations for the management of hip and knee osteoarthritis (OA), which are adaptable and designed to assist physicians and allied health care professionals in general and specialist practise throughout the world. Methods: Sixteen experts from four medical disciplines (primary care, rheumatology, orthopaedics and evidence-based medicine), two continents and six countries (USA, UK, France, Netherlands, Sweden and Canada) ...
August 28, 2013 - Experts have found that radiation dosage can have serious complications for patients with cancer. Cancer patients who receive chest radiation should be evaluated for heart disease before beginning radiation, and every five to 10 years afterward, according to the American Society of Echocardiography (ASE) and the European Assn. of Cardiovascular Imaging (EACVI) of the European Society of Cardiology (ESC). This expert consensus statement on the use of imaging to detect radiation-induced heart disease (RIHD) will be published in the September issue of the Journal of the American Society of Echocardiography (JASE). The writing group was co-chaired by Vuyisile Nkomo, M.D., an echocardiographer from the renowned Mayo Clinic in Rochester, Minn.. When asked about the need for this expert consensus statement, Nkomo said, In the past, patients received high doses of radiation to the chest to treat breast cancer or lymphoma or esophageal cancer, but without adequate shielding of the ...
Dr Ileana Piña discusses a new guideline on atrial fibrillation and a consensus statement addressing cardiovascular toxicity in cancer treatment.
Table of Contents Table of Contents 1. Introduction 2. Consensus Statements on Ridge Augmentation and Review of the Literature 2.1. Consensus Statements and Treatment Guidelines Formulated at the 2008 ITI Consensus Conference 2.1.1. Consensus Statement...
The Delphi process, which was carried out over a period of nine months consisted of a pilot round, two written rounds and a final face-to-face meeting. Sixty infectious disease experts who were national experts in the field of infectious diseases who working at senior levels nationally and internationally, and represented their country on the Advisory Forum of the European Centre for Disease Control, Stockholm (ECDC) were approached. Of the 60, 47 accepted the invitation-written consent was obtained from them. Thirty-eight experts (from 22 countries) participated in the 1st written round and 28 experts (from 19 countries) in the 2nd written round; and 11 newly recruited experts with similar expertise as the participants from the written rounds (as five panellists invited from the written rounds were not able to participate ) from 9 countries participated in the face-to-face meeting. A possible explanation for this is that as national experts, they were extremely busy, and also the panelists were ...
Health,... Patient safety in hospitals focus of 48 NQF-endorsed measures ...WASHINGTON May 15 -- Recognizing that patient... It has been difficult to make real progress in patient safety in this...NQF-endorsed voluntary consensus standards are widely viewed as the g...,National,Quality,Forum,Endorses,Consensus,Standards,for,Quality,of,Hospital,Care,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
BACKGROUND AND PURPOSE: Transcranial color-coded duplex sonography has become a standard diagnostic technique to assess the intracranial arterial status in acute stroke. It is increasingly used for the evaluation of prognosis and the success of revascularization in multicenter trials. The aim of this international consensus procedure was to develop recommendations on the methodology and documentation to be used for assessment of intracranial occlusion and for monitoring of recanalization. METHODS: Thirty-five experts participated in the consensus process. The presented recommendations were approved during a meeting of the consensus group in October 2008 in Giessen, Germany. The project was an initiative of the German Competence Network Stroke and performed under the auspices of the Neurosonology Research Group of the World Federation of Neurology. RESULTS: Recommendations are given on how examinations should be performed in the time-limited situation of acute stroke, including criteria to assess ...
Governmental and private organizations often develop recommendations for the prevention, diagnosis, and treatment of various disorders. These recommendations regarding appropriate clinical decisions are usually made by a group of experts after they assess the available evidence. Recommendations may be published as consensus statements developed at a conference or as clinical practice guidelines (sometimes called practice parameters) developed over time. In either case, publication of the recommendations should identify the sponsor and the participating experts, explain how the participants were selected, describe the evidence that supports the recommendations, and explain the process for achieving consensus in reaching the conclusions. Structured abstracts
CIPO is pleased to be part of a coalition of Canadian Patient organizations that came together through the International Federation on Ageing (IFA), to discuss adult influenza vaccination. On September 5 the IFA is pleased to release the consensus statement Uniting Diverse Groups to Improve Adult Influenza Vaccination in Canada as a result of the Adult Influenza Vaccination: Calling Canadian Patient Organizations to Action expert meeting held in June 2019. This consensus statement is an important step forward in forming a cohesive voice that supports improvements in vaccination practices in Canada.. Press Release - Consensus Statement. Consensus Statement - Uniting Diverse Groups to Improve Adult Influenza Vaccination. ...
TY - JOUR. T1 - Comparison of four methods for assessing the importance of attitudinal beliefs. T2 - An international Delphi study in intensive care settings. AU - Francis, Jill J. AU - Duncan, Eilidh M. AU - Prior, Maria E. AU - Maclennan, Graeme. AU - Marshall, Andrea P. AU - Wells, Elisabeth C. AU - Todd, Laura. AU - Rose, Louise. AU - Campbell, Marion K. AU - Webster, Fiona. AU - Eccles, Martin P. AU - Bellingan, Geoff. AU - Seppelt, Ian M. AU - Grimshaw, Jeremy M. AU - Cuthbertson, Brian H. AU - for the SuDDICU study groups. N1 - © 2013 The British Psychological Society.. PY - 2014/5. Y1 - 2014/5. N2 - Behaviour change interventions often target important beliefs. The literature proposes four methods for assessing importance of attitudinal beliefs: elicitation frequency, importance ratings, and strength of prediction (bivariate and multivariate). We tested congruence between these methods in a Delphi study about selective decontamination of the digestive tract (SDD). SDD improves ...
Recommendations for the practical management of CRT patients have been set out for the first time in an international consensus statement on cardiac resynchronization therapy (CRT) in heart failure.
TY - JOUR. T1 - Position Paper on laboratory testing for patients on direct oral anticoagulants. A Consensus Document from the SISET, FCSA, SIBioC and SIPMeL. AU - Tripodi, Armando. AU - Ageno, Walter. AU - Ciaccio, Marcello. AU - Legnani, Cristina. AU - Lippi, Giuseppe. AU - Manotti, Cesare. AU - Marcucci, Rossella. AU - Moia, Marco. AU - Morelli, Benedetto. AU - Poli, Daniela. AU - Steffan, Agostino. AU - Testa, Sophie. PY - 2018/9. Y1 - 2018/9. N2 - Although direct oral anticoagulants (DOAC) do not require dose-adjustment on the basis of laboratory test results, the measurement of their anticoagulant effect is useful in special situations. This position paper issued by the Italian Scientific Societies that are mainly involved in the management of patients on DOAC is aimed at providing guidance to care-givers on which tests should be used and the situations in which testing is useful. The guidance is based on the data from the literature so far available and/or on consensus among ...
Barnhart K, van Mello NM, Bourne T, Kirk E, Van Calster B, Bottomley C, Chung K, Condous G, Goldstein S, Hajenius PJ, Mol BW, Molinaro T, OFlynn OBrien KL, Husicka R, Sammel M, Timmerman D. Pregnancy of unknown location: A consensus statement of nomenclature, definitions, and outcome. Fertil Steril 2011; 95(3): 857-866. PMCID: PMC 3032825. U.S. National Library of Medicine abstract ...
Peters SE, Johnston V, Coppieters M, and Ross M. Journal of Hand Surgery (European Volume) 2017; 42(2):127-136. DOI: 10.1177/1753193416669263 This Delphi study aimed to reach consensus on important facilitators and barriers for return-to-work (RTW) following surgery for non-traumatic upper extremity (UE) conditions. In Round 1, experts (n=42) listed 134 factors, which were appraised in Round [...] ...
The Trauma Hemostasis and Oxygenation Research (THOR) Network has developed a consensus statement on the role of permissive hypotension in remote damage control resuscitation (RDCR). A summary of the evidence on permissive hypotension follows the THOR Network position on the topic. In RDCR, the burden of time in the care of the patients suffering from noncompressible hemorrhage affects outcomes. Despite the lack of published evidence, and based on clinical experience and expertise, it is the THOR Networks opinion that the increase in prehospital time leads to an increased burden of shock, which poses a greater risk to the patient than the risk of rebleeding due to slightly increased blood pressure, especially when blood products are available as part of prehospital resuscitation.The THOR Networks consensus statement is, In a casualty with life-threatening hemorrhage, shock should be reversed as soon as possible using a blood-based HR fluid. Whole blood is preferred to blood components. As a part of
Lansang P, Lara-Corrales I, Bergman JN, Hong CH, Joseph M, Kim VHD, Lam JM, Landells I, Marcoux D, Prajapati VH, Ramien ML, Spring S. Approach to the Assessment and Management of Pediatric Patients With Atopic Dermatitis: A Consensus Document. Section IV: Consensus Statements on the Assessment and Management of Pediatric Atopic Dermatitis. J Cutan Med Surg. 2019 Nov/Dec; 23(5_suppl):32S-39S ...
William (Bill) Hordern". Consensus. 35 (2). art. 2. Retrieved February 15, 2019. Kamminga, Menno R. (2012). "Structure and Sin ...
Nation state 319-323.......Political Geography 327...........Sovereignty 328.2.........Consensus. Consent of the governed 328.6 ...
Enns, Elaine L. (2016). "Trauma and Memory: Challenges to Settler Solidarity". Consensus. 37. Smith, p. 314-315. The Makhnos of ... Accessed from: https://scholars.wlu.ca/cgi/viewcontent.cgi?article=1335&context=consensus Epp, Marlene Mennonite Women in ...
London : S.P.C.K. "The historic episcopate in Anglican ecclesiology the esse perspective". Consensus. 12 (1). 1986. ISSN 2369- ...
"Consensus! Engineering students need more management education." Journal of Management in Engineering 12.6 (1996): 17-29. " ...
Tucker, Ansley (1986). "The Historic Episcopate in Anglican Ecclesiology: The Esse Perspective". Consensus. 12 (1): 99-115. ...
"Hunger and Malnutrition". Copenhagen Consensus. Retrieved 2 September 2018. Behrman, Jere; Hoddinott, John (2005). "Program ... Hoddinott together with Jere Behrman and Harold Alderman authored a report for the Copenhagen Consensus that attempted to ...
"Scientific Consensus , LymeScience". LymeScience. Retrieved April 22, 2021. Fishburn, Alison (February 11, 2020). "Avril ...
Dye C, Scheele S, Dolin P, Pathania V, Raviglione MC (August 1999). "Consensus statement. Global burden of tuberculosis: ...
Consensus Economics, publisher of Consensus Forecasts, a monthly publication with macroeconomic forecasts of 85 countries based ... in some cases comparing these to consensus forecasts such as those published by Consensus Economics.[citation needed] A 2000 ... "The IMF and OECD versus Consensus Forecasts" (PDF). Consensus Economics. Archived from the original (PDF) on October 28, 2015. ... A 2001 paper by Roy Batchelor of City University Business School, London compared the Consensus Forecasts with forecasts made ...
"Scientific Consensus , LymeScience". LymeScience. Retrieved April 22, 2021. "Gigi Hadid wins $25,000 for charity in cooking ...
Jakobson, Leo (31 December 2019). "Justin Sun's BitTorrent buys DLive streaming platform". Modern Consensus. Archived from the ...
"How does Nunavut's consensus government work?". CBC News. 28 October 2017. Retrieved 20 March 2020. "Consensus Government , ... The Legislative Assembly of Nunavut is a public government and operates on the consensus model. Members of the Legislative ...
"10 Smartest NFL Players". College Consensus. December 20, 2018. Retrieved September 18, 2019. Cwalinski, Jamie (April 10, 2006 ...
"Copenhagen Consensus 2012 - Outcomes". Copenhagen Consensus. Retrieved 14 May 2012. "World Malaria Report 2011". World Health ... As part of the Copenhagen Consensus 2012, a panel of leading economists concluded that the AMFm was "one of the best returns on ...
Dublin, Consensus. "The Dublin Consensus Statement on vital issues relating to the collection of blood and plasma and the ... and Dublin Consensus (2010). The IFBDO was founded in Luxembourg on December 4, 1955. The Headquarters are established in ...
Vowles, Jack (2013). Towards Consensus?: The 1993 Election and Referendum in New Zealand and the Transition to Proportional ...
"Thomas Schelling". Copenhagen Consensus. Retrieved January 16, 2016. "NAS Award for Behavior Research Relevant to the ... Schelling was a contributing participant of the Copenhagen Consensus. In 1977, Schelling received The Frank E. Seidman ...
The goal is to rule by a consensus decision making process. Strong local coalitions are considered a prerequisite to higher- ... "Spinifex 4, Newsletter of the 2001 Global Greens Congress" (PDF). Consensus Productions. "Alain LIPIETZ à BOGOTA du 3 au 5 mars ... based on direct citizen involvement and consensus decision making, wherever it is feasible. Green politics also encourages ...
CS1 maint: discouraged parameter (link) "Spinifex, Newsletter of the Global Greens 2001 Conference" (PDF). Consensus ...
The present consensus is that there is no evidence of human activity at the Calico Early Man site. This consensus developed ... 2015). "[1]"...Current Consensus. Calico Mountains Archaeological Site from the Friends of Calico History portal Paleontology ... The general scientific consensus is that the subsurface items are geofacts. The artifactual character of the Calico lithic ...
The goal of consensus conferences is for members of the lay audience to deliberate and reach a consensus over a particular ... Assembly on Electoral Reform Local Health Integration Network MASS LBP The Danish consensus conference model Consensus ... Consensus conferences originated in Denmark in the 1980s and are one of the earliest attempts by policymakers to include the ... The purpose of consensus conferences is "to qualify people's attitudes, inasmuch as they are given all the information they ...
In 2002, the consensus conferences in France and in the USA raised the possibility of treating patients with chronic hepatitis ... Consensus conference statements recommended liver biopsy in the management of almost all patients with hepatitis C and B. ... November 2002). "Recommendations from the National Institutes of Health consensus development conference statement: management ... "Consensus conference. Treatment of hepatitis C". Gastroenterol. Clin. Biol. 26 (Spec No 2): B303-20. PMID 12180305. ( ...
The consensus . . . appears to be that patents should not be issuing for new business methods." The Supreme Court affirmed the ...
Phase 3 in the Mapping Process is critical because "if we don't have consensus on where we want to go, we will never get there ... A development of a consensus map (also called an essential map, core map, district map, or master map) takes places in Phase 3 ... By the daily trial and error that is inherent in an individual map, resources might be suggested to the consensus map. There ... While the standard is the same and would be represented on the consensus map (as would the common assessments), the individual ...
Final consensus statements, editorial notes and executive summary] Modi, SJ; Pollock, NW (2006); Development of the DAN breath- ... Freiberger, JJ; Lyman, SJ; Peiper, CF; Vann, RD (2004); Consensus factors used by experts in the diagnosis of DCI. Richardson, ... Freiberger, JJ; Lyman, SJ; Peiper, CF; Vann, RD (2004). "Consensus factors used by experts in the diagnosis of DCI". Undersea ... Contents; Dedication About DAN Acknowledgments; 2002 Consensus guidelines for flying after recreational diving; Executive ...
See templates for discussion to help reach a consensus. › Deprescribing is a feasible and safe intervention. Deprescribing ... Consensus validation". International Journal of Clinical Pharmacology and Therapeutics. 46 (2): 72-83. doi:10.5414/cpp46072. ... consensus recommendations from a multidisciplinary expert panel". Internal Medicine Journal. 46 (10): 1189-1197. doi:10.1111/ ... Consensus recommendations from an interdisciplinary panel of experts". International Pharmaceutical Federation (FIP) World ...
Winnipeg Consensus. April 8-10, 2010. Retrieved September 17, 2019. "Winnipeg Consensus". Winnipeg Consensus. Retrieved ... In this role, he also participated in the Winnipeg Consensus, which began with an unprecedented meeting held in October 2009, ... Carr's earlier work on the Winnipeg Consensus formed the basis for Generation Energy, his signature initiative as Minister of ...
The one thing the Emmys is still very good at? Creating consensus. But maybe that's the problem. This year, the consensus was ...
In more recent years, a consensus has evolved in both countries on the importance of developing good relations, as well as a ... Copenhagen Consensus. Archived from the original on 16 April 2016. Retrieved 7 April 2016. "Statistics". UNICEF. 18 December ... "Bangladesh Priorities: Poverty, Sulaiman and Misha , Copenhagen Consensus Center". copenhagenconsensus.com. ...
Both the process and outcome of consensus decision-making are referred to as consensus (e.g. "by consensus" and "a consensus" ... Consensus decision-making or consensus politics (often abbreviated to consensus) is group decision-making processes in which ... "Consensus Decision Making Articles for learning how to use consensus process - Adapted from Randy Schutt". Consensus Decision- ... Consensus[edit]. The word consensus comes from Latin meaning "agreement, accord", which in turn comes from consentire, meaning ...
Published in Print: March 27, 2002, as Reaching Consensus Related Stories. * Return to the main story, Negotiators Retain ...
Consensus momentum regarding action on climate change? Phony, contrived talking points, unscientific propositions, and a scorn ... Consensus momentum regarding action on climate change? Phony, contrived talking points, unscientific propositions, and a scorn ... So where did that famous "consensus" claim that "98% of all scientists believe in global warming" come from? It originated from ... So where did that famous "consensus" claim that "98% of all scientists believe in global warming" come from? It originated from ...
The CCDS database identifies a core set of human protein coding regions that are consistently annotated by multiple public resources and pass quality tests.
... By Catherine Gewertz. - September 22, 2008 , Corrected: February 22, 2019 15 min read ... A version of this article appeared in the September 24, 2008 edition of Education Week as Consensus on Learning Time Builds ...
President-hawk George W. Bush arrived in Beijing 30 years after president-hawk Nixons visit - this is a day-to-day coincidence. Is it possible to find ano...
The GNU consensus community gathers on the Freenode IRC channel #consensus. GNU consensus Wiki. Work in progress is available ... The GNU consensus may produce software: when it does, it is free software; you can redistribute it and/or modify it under the ... Due to the nature and youth of the project, we currently provide a unique list ,consensus@gnu.org,. As the project evolves, ... GNU consensus is currently being maintained by hellekin. Please use the mailing lists for contact.. Licensing. ...
But what kind of consensus would you find if you skipped reading thoroughly vetted research papers and just walked up to ... You are free to disagree with my characterization of the consensus as "virtually unanimous," if you feel 99.83 percent doesnt ... and found that none disagreed with the consensus about man-made climate change. ...
Speaking at a news conference in the capital, Brasilia, Roberto Azevedo said hed strive to build consensus between developed ... without imposing views on anyone and trying to forge all possible consensuses." ... nudge opposing sides into sitting down together and said that he personally has demonstrated a similar capacity for consensus ...
An international panel of obesity experts has issued a joint consensus statement calling for an end to the "pervasive, ... Nonetheless, she said, "Overall, I think this consensus statement is good. We dont want people to feel embarrassed or ashamed ... Cite this: International Consensus Statement Combats Obesity Stigma - Medscape - Mar 06, 2020. ... With respect to healthcare, the consensus statement warns against "negative attitudes about obesity, including stereotypes that ...
Consensus on preventing osteoporosis. Br Med J (Clin Res Ed) 1987; 295 :872 ... Consensus on preventing osteoporosis.. Br Med J (Clin Res Ed) 1987; 295 doi: https://doi.org/10.1136/bmj.295.6603.872 ( ...
Based on consensus-based distributed support vector machines, we present a new consensus-based privacy-preserving algorithm to ... Based on consensus-based distributed support vector machines, we present a new consensus-based privacy-preserving algorithm to ... Li H., Xu F. (2019) Consensus-Based Privacy-Preserving Algorithm. In: Liang Q., Mu J., Jia M., Wang W., Feng X., Zhang B. (eds ... Forero, P.A., Cano, A., Giannakis, G.B.: Consensus-based distributed support vector machines. J. Mach. Learn. Res. 11, 1663- ...
The group meets annually to produce a consensus statement, which is a blend of evidence-based research and expert consensus. ... The Team Physician Consensus Conference is a project-based alliance. ... Team Physician Consensus Statement , 2013 Update *The Team Physician and the Return-to-Play Decision: A Consensus Statement , ... About Team Physician Consensus Conference Statements. Definition:. The Team Physician Consensus Conference (TPCC) is a project- ...
SOSORT consensus paper: school screening for scoliosis. Where are we today? This report is the SOSORT Consensus Paper on School ... SOSORT 2012 consensus paper: reducing x-ray exposure in pediatric patients with scoliosis This 2012 Consensus paper reviews the ... 8th SOSORT consensus paper This report is the SOSORT Consensus Paper on Terminology for use in the treatment of conservative ... SOSORT 2005 Consensus paper Medicine is a scientific art: once science is not clear, choices are made according to individual ...
A consensus statement is a comprehensive analysis by a panel of experts (i.e., consensus panel) of a scientific or medical ... A consensus statement is developed immediately after a consensus conference at which presentations are made on the issue under ... Proceedings of a Consensus Development Conference on Standardized Measures in Diabetic Neuropathy Diabetes Care 15:1080-1107, ... The need for a consensus statement arises when clinicians or scientists desire guidance on a subject for which there is a ...
How can this be reconciled with the above -"professor " - understanding of consensus?]" Consensus, consensus building ("style ... This group-made set of choices is said to be the consensus of the group. The group consensus is then relayed back to the rest ... The Signed Consensus Statement on Climate Change by 18 Associations. Signed Consensus Statement on Climate Change by 11 ... I agree with Matt I think on consensus. I am quite sure that deniers havent thought through the steps to consensus and come to ...
Yue J. (2018) The 1990s: Washington Consensus in China?. In: Chinas Rise in the Age of Globalization. Palgrave Studies in ...
Re: [LAZY CONSENSUS] Definining Apache NetBeans D... Neil C Smith. * *Re: [LAZY CONSENSUS] Definining Apache NetBea... Geertjan ... Re: [LAZY CONSENSUS] Definining Apache NetBeans D... Antonio. * *Re: [LAZY CONSENSUS] Definining Apache NetBea... mark stephens ... Re: [LAZY CONSENSUS] Definining Apache NetBeans D... Bertrand Delacretaz. * *Re: [LAZY CONSENSUS] Definining Apache NetBea... ... LAZY CONSENSUS] Definining Apache NetBeans Days Geertjan Wielenga. * *Re: [LAZY CONSENSUS] Definining Apache NetBeans D... ...
Indian telecom operators are negotiating with the government on a framework for BlackBerry usage that will allow the Indian market to expand but also meet concerns for national security.
Nuclear targeting sequences--a consensus?. Dingwall C1, Laskey RA.. Author information. 1. Wellcome Trust/Cancer Research ... We suggest in this review that, despite this diversity, a consensus bipartite motif can be identified. ...
Abstract: In 2011, one in three women who gave birth in the United States did so by cesarean delivery. Cesarean birth can be life-saving for the fetus, the mother, or both in certain cases. However, the rapid increase in cesarean birth rates from 1996 to 2011 without clear evidence of concomitant decreases in maternal or neonatal morbidity or mortality raises significant concern that cesarean delivery is overused. Variation in the rates of nulliparous, term, singleton, vertex cesarean births also indicates that clinical practice patterns affect the number of cesarean births performed. The mos... ...
... World Allergy Organ J. 2014 May 30;7(1):9. doi: 10.1186/1939-4551-7-9. ...
You are here Research , Research Groups , Environmental Governance , Projects , CONSENSUS CONSENSUS: Consumption, Environment ... Phase I of CONSENSUS examined four key areas of household consumption that currently impact negatively on the environment and ... CONSENSUS has generated a suite of tangible data and recommendations for public, private and civil society actors in Ireland ... Phase II of CONSENSUS featured three complementary work packages that apply lifestyle segmentation profiling, living laboratory ...
books.google.comhttps://books.google.com/books/about/Animal_experimentation.html?id=k6pqAAAAMAAJ&utm_source=gb-gplus-shareAnimal experimentation ...
Title: PP - Financial Instability1 FINISHED, Author: Copenhagen Consensus Center, Name: PP - Financial Instability1 FINISHED, ... This paper was produced for the Copenhagen Consensus 2004 project. The final version of this paper can be found in the book, ... Copenhagen Consensus Comments on the Challenge Paper on Communicable Diseases Jacques van der Gaag March 2004 ... Copenhagen Consensus Opponent Note Not to be released before 16 April 2004 ...
These oligonucleotides contain consensus DNA-binding sites for individual transcription factors and have 5´ OH blunt ends, ... NF-κB Consensus Oligonucleotide. NF-κB transcription factor consensus oligonucleotide. Component of Gel Shift Assay System. ... AP1 Consensus Oligonucleotide. AP1 transcription factor consensus oligonucleotide. Component of Gel Shift Assay System. ... AP2 Consensus Oligonucleotide. AP2 transcription factor consensus oligonucleotide. Component of Gel Shift Assay System. ...
Day Time Consensus Est Last PeriodT 10:00 April Consumer Confidence 105.0% 107.2%10:00 March Existing Home Sales 6.40 mil 6.69 ...
... TCP Home. My Ratings. Rate Abstracts. FAQ. Visualization. Search. ...
  • Yue J. (2018) The 1990s: Washington Consensus in China? (springer.com)
  • Based on consensus-based distributed support vector machines, we present a new consensus-based privacy-preserving algorithm to conduct secure multi-party computation. (springer.com)
  • In the second algorithm, sensors iteratively reach consensus on the average (cross-) covariances of locally available per-sensor data vectors with the corresponding AP-tosensor channel matrices, which constitute sufficient statistics for maximum likelihood demodulation. (psu.edu)
  • Raft is a consensus algorithm for managing a replicated log. (usenix.org)
  • That Scientific Global Warming Consensus. (forbes.com)
  • For the Wikipedia policy on consensus, see Wikipedia:Consensus . (wikipedia.org)
  • ARTICLE{Zhu10distributedconsensus-based, author = {Hao Zhu and Student Member and Alfonso Cano and Student Member and Georgios B. Giannakis}, title = {Distributed consensus-based demodulation: algorithms and error analysis}, journal = {IEEE Trans. (psu.edu)
  • A good reference for discrete time consensus algorithms and theoretical explanation for consensus of multi-agent systems using nearest neighbor rules. (caltech.edu)
  • A good reference for continuous time consensus algorithms. (caltech.edu)
  • In the blockchain world, the techniques utilized to achieve agreement and make the network harder to attack are typically referred to as consensus algorithms. (tibco.com)
  • Speaking at a news conference in the capital, Brasilia, Roberto Azevedo said he'd strive to build consensus between developed and developing countries in hopes of resuming the so-called Doha Round of talks that began in 2001 but have not reached agreement. (yahoo.com)
  • Turkey's Prime Minister Recep Tayyip Erdogan has promised to build consensus with opposition parties, after securing a third term in office. (bbc.com)
  • A smaller meta-study, conducted by Naomi Oreskes in 2005, reviewed 985 papers published between 1993 and 2003, and found that none disagreed with the consensus about man-made climate change. (huffingtonpost.com)
  • Authors of seven climate consensus studies - including Naomi Oreskes , Peter Doran , William Anderegg , Bart Verheggen , Ed Maibach , J. Stuart Carlton , and John Cook - co-authored a paper that should settle this question once and for all. (skepticalscience.com)
  • BETHESDA, Md. -- Nov. 16, 2017 -- The Association for Molecular Pathology (AMP), the premier global, non-profit molecular diagnostics professional society, today published 17 consensus recommendations to help clinical laboratory professionals achieve high-quality sequencing results and deliver better patient care. (eurekalert.org)
  • AMP members are among the early adopters and users of NGS technology in a clinical setting and these best practice consensus standards and guidelines are based on our collective knowledge and expertise," said Alexis B. Carter, MD, Physician Informaticist at Children's Healthcare of Atlanta, Working Group Member, 2017 AMP Informatics Subdivision Chair, and AMP Board Member. (eurekalert.org)
  • Key methodological issues in using the methods are discussed, along with the distinct contribution of consensus methods as aids to decision making, both in clinical practice and in health service development. (bmj.com)
  • His answers reflected, in part, a broad consensus laid out in a September 2016 memo prepared by the National Intelligence Council, which advises U.S. intelligence agencies, and said that climate change presents risks to stability, human health, and food supplies. (reuters.com)
  • An international panel of obesity experts has issued a joint consensus statement calling for an end to the "pervasive, resilient form of social stigma" associated with the disease. (medscape.com)
  • With respect to healthcare, the consensus statement warns against "negative attitudes about obesity, including stereotypes that affected patients are lazy, lack self-control and willpower, are personally to blame for their weight, and are noncompliant with treatment. (medscape.com)
  • The group meets annually to produce a consensus statement, which is a blend of evidence-based research and expert consensus. (acsm.org)
  • A consensus statement is a comprehensive analysis by a panel of experts (i.e., consensus panel) of a scientific or medical issue related to diabetes. (diabetesjournals.org)
  • A consensus statement is developed immediately after a consensus conference at which presentations are made on the issue under review. (diabetesjournals.org)
  • The need for a consensus statement arises when clinicians or scientists desire guidance on a subject for which there is a relative deficiency of comprehensive evidence that might otherwise allow for a more definitive statement to be made. (diabetesjournals.org)
  • These consensus probabilities are different from the average of the subjective probabilities which is used in the conventional way of combining individually held opinions into a collective group statement. (repec.org)
  • AACE and ACE conduct bring together key experts and thought leaders on particular endocrine topics to review data and research to ultimately develop a consensus statement. (aace.com)
  • Tell students if they are unable to reach consensus they may alter the phrasing of the statement in order to do so. (readwritethink.org)
  • That is according to the consensus statement released June 3 by the American College of Veterinary Internal Medicine on the disease, which draws together current knowledge on the disease. (avma.org)
  • The consensus statement concludes: 'Our understanding of the features of EHV-1 is increasing, but there is more to learn before we can best address the challenges that this virus presents. (avma.org)
  • The consensus statement was aimed at updating quality standards for CTC based on a literature review and the opinions of CTC experts on the ESGAR panel. (auntminnie.com)
  • A 1- or 2-paragraph statement describing aspects of the consensus conference that are unique and compelling. (saem.org)
  • The consensus statement begins by offering important background information on the prevalence of AAOCA among young people and the risk for SCD. (eurekalert.org)
  • The International Consensus Statement on Concussion in Sport was created using the latest scientific evidence to give players and medical staff the best tools for handling concussions on a case-by-case basis. (consumeraffairs.com)
  • The consensus statement discusses at length how doctors and health professionals should care for athletes at various levels of competition - from children under the age of 12 all the way up to adult athletes. (consumeraffairs.com)
  • In the ensuing weeks, ACSM's TPCC Executive Committee reviews the paper again, along with the consultant, experts and ACSM's chief science officer to ensure references are correct and that all statements are backed by evidence-based literature or expert consensus. (acsm.org)
  • Consensus statements are published in American Diabetes Association journals and other scientific/medical journals, as appropriate. (diabetesjournals.org)
  • Listed below are recent consensus statements. (diabetesjournals.org)
  • Consensus statements examine several issues that are addressed in order to provide physicians information to guide them in treating their patients. (aace.com)
  • In those instances, PHA's Scientific Leadership Council (SLC) convenes to analyze the issue, and from those interactions, Consensus Statements are developed. (phassociation.org)
  • CONSENSUS has generated a suite of tangible data and recommendations for public, private and civil society actors in Ireland and Europe to support low carbon development that combines efficiency gains with a socially just allocation of resources. (tcd.ie)
  • Most of our recommendations rely on consensus from international experts because there is a relatively small amount of evidence available. (eurekalert.org)
  • Professor Jon Kalman (Australia), APHRS co-chairperson of the writing group, said: "A number of international recommendations overlap with this consensus document but this is the first time that guidance on the management of ventricular arrhythmias has been compiled in one place. (eurekalert.org)
  • The recommendations are based on expert consensus opinion as well as on the best available evidence," explained lead author James S. Tweddell, MD, Executive Co-Director of the Heart Institute and Professor of Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. (eurekalert.org)
  • Scientists change their minds on the basis of the evidence, and a consensus emerges over time. (skepticalscience.com)
  • Generally such rules assume a certain number of participants and thus would satisfy consensus thresholds stated in percentage terms. (wikipedia.org)
  • A plurality rule was chosen over majority consensus because it is more inclusive for pattern matching purposes and does not assign strict thresholds for the dominant virus phase in the sample. (cdc.gov)
  • The coverage table will also be amended when consensus alleles fail to pass thresholds. (cdc.gov)
  • Consensus paper of the WFSBP Task Force on Biological Markers of Dementia: the role of CSF and blood analysis in the early and differential diagnosis of dementia. (gu.se)
  • So where did that famous "consensus" claim that "98% of all scientists believe in global warming" come from? (forbes.com)
  • The IPCC, as the committee is known, represents a consensus view of hundreds of scientists around the world. (npr.org)
  • Science achieves a consensus when scientists stop arguing. (skepticalscience.com)
  • In the scientific field of climate studies - which is informed by many different disciplines - the consensus is demonstrated by the number of scientists who have stopped arguing about what is causing climate change - and that's nearly all of them. (skepticalscience.com)
  • 1) Depending on exactly how you measure the expert consensus, it's somewhere between 90% and 100% that agree humans are responsible for climate change , with most of our studies finding 97% consensus among publishing climate scientists. (skepticalscience.com)
  • most people defer to the expert consensus of climate scientists. (skepticalscience.com)
  • For instance, some scientists have told me that at some point , if the virus is widespread enough, there is no choice but to let it burn its way through the population (not saying we are there yet, probably not according to the consensus of experts I am seeing). (econlib.org)
  • It has become apparent that a disconnect exists between the understood level of agreement, or the Scientific Consensus , on climate change within the scientific community and that of the rest of humanity. (skepticalscience.com)
  • The current level of Scientific Consensus on climate change was expressed most recently by the National Academy of Science in their publication Advancing the Science of Climate Change . (skepticalscience.com)
  • He's been part of the IPCC since its early days in the 1990s and is an outspoken defender of the scientific consensus on climate change. (npr.org)
  • But what kind of consensus would you find if you skipped reading thoroughly vetted research papers and just walked up to members of the climate science community to ask them their convictions? (huffingtonpost.com)
  • The GNU consensus community gathers on the Freenode IRC channel #consensus . (gnu.org)
  • Consensus gathers experiences from the whole group. (cohousing.org)
  • WASHINGTON (Reuters) - U.S. President Donald Trump relies far more than his recent predecessors on advisers with a military background, but his apparent disregard for climate science is at odds with the U.S. military's consensus on the risks of climate change to security. (reuters.com)
  • SAO PAULO (Reuters) - Brazilian President Jair Bolsonaro said on Wednesday he will talk to Congress leaders and his economic team on Thursday to try to reach a consensus regarding the pension reform proposal the government plans to send to the parliament. (reuters.com)
  • April 25 - The Fed economic projections show a strong consensus that the Fed won't move till 2014 at the earliest, says Reuters Columnist James Saft. (reuters.com)
  • Prime Minister Manmohan Singh's [ Images ] visit to China will further consolidate the foundation of friendly cooperation between the two neighbours, who now have more consensus than differences due to efforts to boost mutual trust, a leading official daily said in Beijing [ Images ] on Friday. (rediff.com)
  • The report is the strongest show yet of the scientific consensus on the occurrence and implications of anthropogenic climate change, but it is unlikely to stir up any political action in proportion to the science. (thenation.com)
  • There was wide agreement that the AMSP is a good document but there is also strong consensus that - due to its 2015 to 2025 timeframe - it might be time to revise parts of the strategy. (arctic-council.org)
  • By the end of last week, it had became clear that the effort to achieve consensus necessitated serious compromises. (rferl.org)
  • It said the five permanent members of the Security Council, plus Germany, have failed to achieve consensus on Iran's 'peaceful' nuclear program. (rferl.org)
  • Practical Byzantine Fault Tolerance (PBFT / Hyperledger Fabric), Federated Byzantine Agreement (FBA / Stellar), and Delegated Byzantine Fault Tolerance (dBFT / Neo) are all protocols that have been introduced in an attempt to achieve consensus in this distributed, non-centralized world. (tibco.com)
  • Research in this area has subsequently led to various other related approaches, with the overall goal being to achieve consensus in an environment where machines may fail at any time or behave maliciously. (tibco.com)
  • IRMA uses both the average consensus allele quality score as well as the consensus allele coverage depth. (cdc.gov)
  • Plurality consensus sequences are returned in the main folder and are named after the virus genome or gene segment class label, see the IRMA output page for more details . (cdc.gov)
  • These sequences are modifications to the plurality consensus. (cdc.gov)
  • The general consensus of the sequences. (psu.edu)
  • will appear in main folder for the plurality alignment and also in the amended_consensus folder. (cdc.gov)
  • We will be seeking consensus with the main opposition, the opposition, parties outside of parliament, the media, NGOs, with academics, with anyone who has something to say. (bbc.com)
  • This 2012 Consensus paper reviews the literature on side effects of x-ray exposure in the pediatric population as it relates to scoliosis evaluation and treatment. (biomedcentral.com)
  • This report is the SOSORT Consensus Paper on Terminology for use in the treatment of conservative spinal deformities. (biomedcentral.com)
  • This paper was produced for the Copenhagen Consensus 2004 project. (issuu.com)
  • A new consensus paper was launched during the annual meeting of the EASD in Berlin following a review of the latest evidence - including a range of recent trials of drug and lifestyle interventions. (springer.com)
  • A single 10,000-word consensus conference paper will, if high quality, be strongly considered for publication in AEM by the editor-in-chief. (saem.org)
  • The consensus development conference will not be covered in this paper because it requires resources beyond those at the disposal of most researchers (unlike the other two methods), is commonly organised within defined programmes (for example, by the King's Fund in Britain and the National Institutes of Health in the United States), and has been discussed at length elsewhere. (bmj.com)
  • The scientific consensus is clearly expressed in the reports of the Intergovernmental Panel on Climate Change (IPCC). (sciencemag.org)
  • In its most recent assessment, IPCC states unequivocally that the consensus of scientific opinion is that Earth's climate is being affected by human activities: "Human activities … are modifying the concentration of atmospheric constituents … that absorb or scatter radiant energy. (sciencemag.org)
  • The focus on establishing agreement of the supermajority and avoiding unproductive opinion, differentiates consensus from unanimity , which requires all participants to support a decision. (wikipedia.org)
  • Consensus is not synonymous with "unanimity"- though that may be a rule agreed to in a decision making process. (wikipedia.org)
  • That is, if a majority of nine may override three in a group of twelve, that is a 75% consensus threshold but it is also a "unanimity minus three" threshold, and may be stated either or both ways, as in "75% or unanimity minus three whichever is harder to achieve", in a group's constitution. (wikipedia.org)
  • The focus of consensus methods lies where unanimity of opinion does not exist owing to a lack of scientific evidence or where there is contradictory evidence on an issue. (bmj.com)
  • Rawls elaborates that the existence of an overlapping consensus on conceptions of justice among major social groups holding differing-yet reasonable-comprehensive doctrines is a necessary and distinctive characteristic of political liberalism. (wikipedia.org)
  • Chiang's pledge plays right into the KMT's insistence on abiding by the controversial consensus, whose existence is denied by both the Democratic Progressive Party (DPP) and former president Lee Teng-hui (李登輝), who was in office at the time the agreement was alleged to have been struck. (taipeitimes.com)
  • That's why those who oppose taking action to curb climate change have engaged in a misinformation campaign to deny the existence of the expert consensus. (skepticalscience.com)
  • Referring to the consensus reached by the two neighbours over climate change and energy supply, the article said both governments had realised that the strategic and cooperative partnership between China and India was in their interests and "is conducive to peace, stability and prosperity of Asia and the world. (rediff.com)
  • But when it comes to communicating the consensus of climate science, it does not. (skepticalscience.com)
  • And while these days he's a staunch advocate for the scientific consensus, his first foray into climate science was a cut across the grain. (npr.org)
  • There's a strong correlation between consensus and climate science expertise. (skepticalscience.com)
  • Five state finance ministers Mint spoke to confirmed the 1 July deadline, signifying political consensus across political parties. (livemint.com)
  • New Perspectives on Distributive Justice: Deep Disagreements, Pluralism, and the Problem of Consensus. (wikipedia.org)
  • Below is all of the content on our site that has been tagged Consensus . (cohousing.org)
  • Participants in an effective consensus process should strive to reach the best possible decision for the group and all of its members, rather than competing for personal preferences. (wikipedia.org)
  • Networks of agents that exchange information to reach consensus include: physiological systems, gene networks, large-scale energy systems and fleets of vehicles on land, in the air or in space. (wikipedia.org)
  • Kemal Derviş and Abigail Jones outline a number of concrete ways to overcome several key sticking points that have marred previous efforts to reach consensus on a post-2012 climate agreement in the short months preceding the negotiations in Copenhagen. (brookings.edu)
  • A report commissioned by the Vatican in 2006 to try and resolve the issue was shelved after the group failed to reach a consensus. (telegraph.co.uk)
  • the goal is to reach consensus through critical discussion. (readwritethink.org)
  • The agreement protocol or consensus protocol is an unforced dynamical system that is governed by the interconnection topology and the initial condition for each agent. (wikipedia.org)
  • Consensus problems in networks of agents with switching topology and time-delays , R. Olfati-Saber and R. M. Murray, IEEE Transactions on Automatic Control, vol. 49, 1520-1533, Sept. 2004. (caltech.edu)
  • This expert consensus provides the best knowledge presently available on how clinicians should evaluate and treat patients with the entire spectrum of ventricular arrhythmias. (eurekalert.org)
  • The Team Physician Consensus Conference (TPCC) is a project-based alliance with partners including the American Academy of Family Physicians, American Academy of Orthopaedic Surgeons, American Medical Society for Sports Medicine, American Orthopaedic Society for Sports Medicine and the American Osteopathic Academy of Sports Medicine. (acsm.org)
  • In advance of the 15th annual Conference of the Parties to the United Nations Framework Convention on Climate Change in Copenhagen this December, world leaders will convene at a number of high-level forums in the hopes of building consensus around key elements of a post-2012 climate change agreement. (brookings.edu)
  • The Society for Academic Emergency Medicine is accepting proposals for the 2021 SAEM consensus conference, to be held May 11, 2021 at SAEM21 in Atlanta, GA. (saem.org)
  • The primary objective of the SAEM Consensus Conference will be to generate a research agenda for important, unanswered questions facing emergency care, to lead to high-quality, funded research projects of varying scopes from a variety of funding sources. (saem.org)
  • The secondary objectives of the SAEM Consensus Conference will include networking between junior and senior researchers, meaningful engagement with stakeholders, and drawing thought leaders to the SAEM Annual Meeting. (saem.org)
  • The consensus conference is not a "state of the art" lecture series, but is intended primarily to create the research agenda that is needed to advance our knowledge of the topic area. (saem.org)
  • The format of the conference will emphasize interactive multi-stakeholder engagement and real-time consensus building. (saem.org)
  • survey instruments) may be created at the discretion of the Consensus Conference leaders, with appropriate extramural funding if needed. (saem.org)
  • If the Consensus Conference will leverage existing meeting planning and organizational resources, it may not need extramural funding (assuming that projected registration fees cover the cost of space/networking events). (saem.org)
  • Consensus Conference title. (saem.org)
  • Additionally, up to 10 planning committee members will receive complimentary registration to the consensus conference only. (saem.org)
  • The three best known consensus methods are the Delphi process, the nominal group technique (also known as the expert panel), and the consensus development conference. (bmj.com)
  • While most people recover in the initial 10-14 day time period following injury, in some cases individuals may have symptoms that persist," said Dr. Willem Meeuwisse, co-chair of the consensus conference and a sport medicine physician and epidemiologist. (consumeraffairs.com)
  • Such random variable R a p p {\displaystyle R_{app}} is called a consensus estimate: "Consensus" means that, with high probability, a single agent cannot influence the outcome, so that there is an agreement between the outcomes with or without the agent. (wikipedia.org)
  • Outcomes are inconsistent, ill-defined and lack consensus limiting the value of published data. (mendeley.com)
  • Consensus estimate is a technique for designing truthful mechanisms in a prior-free mechanism design setting. (wikipedia.org)
  • As a first attempt of a consensus-estimate, let R a p p = ⌊ R m a x ⌋ {\displaystyle R_{app}=\lfloor R_{max}\rfloor } = the value of R m a x {\displaystyle R_{max}} rounded to the nearest integer below it. (wikipedia.org)
  • The disadvantages of using a consensus estimate are: It does not give us the optimal profit - but it gives us an approximately-optimal profit. (wikipedia.org)
  • In the case of digital goods, using this consensus-estimate allows us to attain at least 1/3.39 of the optimal profit, even in worst-case scenarios. (wikipedia.org)
  • Consensus decision-making or consensus politics (often abbreviated to consensus ) is group decision-making processes in which participants develop and decide on proposals with the aim, or requirement, of acceptance by all. (wikipedia.org)
  • [2] Both the process and outcome of consensus decision-making are referred to as consensus (e.g. " by consensus" and " a consensus" respectively). (wikipedia.org)
  • All members of a consensus decision-making body should be afforded, as much as possible, equal input into the process. (wikipedia.org)
  • As many stakeholders as possible should be involved in the consensus decision-making process. (wikipedia.org)
  • The consensus process should actively solicit the input and participation of all decision-makers. (wikipedia.org)
  • Consensus decision-making is an alternative to commonly practiced group decision-making processes. (wikipedia.org)
  • Consensus decision-making attempts to address the beliefs of such problems. (wikipedia.org)
  • Students are introduced to Consensus Decision Making through a critical discussion of a text's central ideas. (readwritethink.org)
  • Consensus decision making is predicated on sociocultural learning theory, specifically the notion that knowledge is fundamentally socially constructed. (readwritethink.org)
  • Consensus decision making provides a scaffold for critical dialogue between the student and the text, the author, and their peers. (readwritethink.org)
  • As per this interpretation, the decision to go for consensus reflects not the desire to uphold fiscal federalism as much as an olive branch extended to the states in order to achieve an early closure. (livemint.com)
  • Searching for Policy-Consensus/Decision Making in the Cohousing-L email archives. (cohousing.org)
  • Cooperative decision-making Decisions are made on a consensus basis. (cohousing.org)
  • Consensus All membership meetings shall operate using a consensus decision making process, except, upon a vote of 75% of the voting interests present at the meeting to break consensus, decision may be made by an affirmative vote of 75% of the voting interests of the Association. (cohousing.org)
  • CONSENSUS DECISION MAKING Consensus is different from most other kinds of decision making because it stresses group members working together to co-operatively develop a decision. (cohousing.org)
  • Consensus-Oriented Decision-Making is the first book to offer groups (and group facilitators) a clear and efficient path togenerating widespread agreement while fostering full participation and true collaboration. (newsociety.com)
  • Business, government, non-profit, social and community organizations can all benefit from Consensus-Oriented Decision-Making . (newsociety.com)
  • This practical and intelligent guide to consensus-oriented decision-making is a must read for people of good will who are engaged in decision-making and progress. (newsociety.com)
  • Tim Hartnett gets it right when he calls consensus an "orientation" rather than a rigid rule or method for decision making. (newsociety.com)
  • Yet it reflects a growing consensus amongst theologians that the stance now adopted by the Pope can be morally justified. (telegraph.co.uk)
  • The plurality consensus sequence is very useful when used with the BAM file to look at minor variants, since the most frequent allele will appear in the reference. (cdc.gov)
  • The final plurality consensus and the final reference are the same sequence! (cdc.gov)
  • and family conservations allow the identification of the most probable consensus sequence element when more than one is present. (pnas.org)
  • Employing these features we have screened the protein sequence data base of the Protein Identification Resource and have identified only known GTP-binding proteins with the exception of protein 2C from foot-and-mouth disease virus as matching the consensus sequence. (pnas.org)
  • This group-made set of choices is said to be the consensus of the group. (skepticalscience.com)
  • The group consensus is then relayed back to the rest of the people, either by the individual members of the committee or by an appointed representative of the committee. (skepticalscience.com)
  • Bought that consensus that group led by Bernanke that expects and 2014 or beyond they've scaled -- back a little bit. (reuters.com)
  • The 928 papers were divided into six categories: explicit endorsement of the consensus position, evaluation of impacts, mitigation proposals, methods, paleoclimate analysis, and rejection of the consensus position. (sciencemag.org)
  • I expect the Sendai Dialogue to help form a consensus on the need to mainstream disaster risk management in all aspects of development processes. (worldbank.org)
  • Consensus delivered to the public from scientific organizations worldwide on climate change is met with derision, vitriol and dismissal. (skepticalscience.com)
  • we'll assume lazy consensus and implement the above proposal. (mail-archive.com)
  • The term overlapping consensus refers to how supporters of different comprehensive normative doctrines-that entail apparently inconsistent conceptions of justice-can agree on particular principles of justice that underwrite a political community's basic social institutions. (wikipedia.org)
  • Scoliosis and Spinal Disorders , the official publication of the Society on Scoliosis Orthopaedic and Rehabilitation Treatment (SOSORT), has published several key consensus & guidelines articles from society meetings and workshops over the years. (biomedcentral.com)
  • Upon being re-elected chairman of the Straits Exchange Foundation (SEF) on Friday, Chiang Pin-kung (江丙坤) vowed to forge ahead with negotiations under the so-called "1992 consensus," a clear sign, if one was needed, that Beijing and the Chinese Nationalist Party (KMT) intend to leave no room for the emergence of alternative approaches to cross-strait talks. (taipeitimes.com)
  • For example, while discussing a major U.S. Environmental Protection Agency report on the risks of climate change, then-EPA administrator Christine Whitman argued, "As [the report] went through review, there was less consensus on the science and conclusions on climate change" ( 1 ). (sciencemag.org)
  • Barcelona, Spain - Saturday 30 August 2014: The first expert consensus on ventricular arrhythmias is published today. (eurekalert.org)
  • The "EHRA/HRS/APHRS Expert Consensus on Ventricular Arrhythmias" is published today on-line in EP Europace (1). (eurekalert.org)
  • 1) EHRA/HRS/APHRS Expert Consensus on Ventricular Arrhythmias. (eurekalert.org)
  • Expert consensus results on the question of human-caused global warming among the previous studies published by the co-authors of Cook et al. (skepticalscience.com)
  • Expert consensus is a powerful thing. (skepticalscience.com)
  • If all you have is one expert, you can't conclude that there's a consensus. (econlib.org)
  • To compile the review, an expert panel was convened to provide a consensus. (hindawi.com)
  • Please read the GNU consensus Manifesto . (gnu.org)