Consciousness Disorders
Unconsciousness
Persistent Vegetative State
Coma
Bipolar Disorder
Mental Disorders
Electroencephalography
Propofol
Anesthetics, Intravenous
Diagnostic and Statistical Manual of Mental Disorders
Glasgow head injury outcome prediction program: an independent assessment. (1/148)
Using an independent data set, the utility of the Glasgow Head Injury Outcome Prediction Program was investigated in terms of possible frequency of use and reliability of outcome prediction in patients with severe head injury, or haematoma requiring evacuation, or coma lasting 6 hours or more, in whom outcome had been reliably assessed at 6 to 24 months after injury. Predictions were calculated on admission, before evacuation of a haematoma, or 24 hours, 3 days, and 7 days after onset of coma lasting 6 hours or more. Three hundred and twenty four patients provided 426 predictions which were possible in 76%, 97%, 19%, 34%, and 53% of patients on admission, before operation, 24 hours, 3 days, and 7 days respectively. Major reasons for non-feasible predictions were that patients were paralysed/ventilated as part of resuscitation or management. Overall, 75.8% of predictions were correct, 14.6% were pessimistic (outcome better than predicted), and 9.6% optimistic (outcome worse than predicted). Of 197 patients (267 predictions) whose eventual outcome was good or moderate, 84.3% of predictions were correct. For death or vegetative survival (96 patients with 110 predictions), 83.6% of predictions were correct but for severe disability (31 patients with 49 predictions), only 12.2% were correctly predicted. The utility of the Glasgow Head Injury Outcome Prediction Program compares favourably with other outcome prediction algorithms for patients with head injury. (+info)High yield criteria for emergency cranial computed tomography in adult patients with no history of head injury. (2/148)
OBJECTIVES: A recent American study identified clinical factors which effectively predicted those patients who would have significant findings on cranial computed tomography. It was proposed to apply these criteria in a UK setting and to determine whether modifications could be made to improve their efficiency. METHODS: A prospective observational study was conducted over a four month period including all non-trauma adult patients referred from the accident and emergency (A&E) department for urgent cranial computed tomography. Presenting symptoms and signs were analysed for ability to predict clinically significant computed tomography findings, namely: acute infarct, malignancy, acute hydrocephalus, intracranial haemorrhage, or intracranial infection. RESULTS: Sixty two patients were included; 22 (35%) had significant findings on computed tomography. Applying the original criteria (any of: age 60 years or older, focal neurology, headache with nausea or vomiting, altered mental status) to the study population showed that no clinically significant tomograms would have been omitted but only 11% fewer performed. Modifying the criteria by removing "age 60 years or older" and replacing "altered mental status" with a Glasgow coma score <14, still ensured 100% sensitivity and would have resulted in 19% fewer scans being performed. CONCLUSION: Simple clinical criteria can be usefully applied to patients presenting to an A&E department in this country to target patients most likely to have clinically significant findings on urgent cranial computed tomography. (+info)Sedation with "non-sedating" antihistamines: four prescription-event monitoring studies in general practice. (3/148)
OBJECTIVES: To investigate the frequency with which sedation was reported in post-marketing surveillance studies of four second generation antihistamines: loratadine, cetirizine, fexofenadine, and acrivastine. DESIGN: Prescription-event monitoring studies. SETTING: Prescriptions were obtained for each cohort in the immediate post-marketing period. SUBJECTS: Event data were obtained for a total of 43 363 patients. MAIN OUTCOME MEASURES: Reporting of sedation or drowsiness. RESULTS: The odds ratios (adjusted for age and sex) for the incidence of sedation were 0.63 (95% confidence interval 0.36 to 1.11; P=0.1) for fexofenadine; 2.79 (1.69 to 4.58; P<0.0001) for acrivastine, and 3.53 (2.07 to 5.42; P<0.0001) for cetirizine compared with loratadine. No increased risk of accident or injury was evident with any of the four drugs. CONCLUSIONS: Although the risk of sedation was low with all four drugs, fexofenadine and loratadine may be more appropriate for people working in safety critical jobs. (+info)A case of sinus pause due to the proarrhythmia of pilsicainide. (4/148)
A 74-year-old man received oral administration of pilsicainide, a pure sodium channel blocker with slow recovery kinetics, to convert paroxysmal atrial fibrillation to sinus rhythm and developed loss of consciousness two days later. The ECG monitoring revealed sinus pause with markedly prolonged PQ interval and QRS width. Two days after the drug was discontinued, the duration of the QRS complex was normalized. This drug is rapidly absorbed from the gastrointestinal tract, most of which is excreted from the kidney. The plasma concentration of pilsicainide, although not measured, must have been very high, since his renal function was impaired. When pilsicainide is prescribed in patients with coronary artery disease or renal dysfunction, close attention must be paid to avoid life-threatening arrhythmias due to high plasma concentrations of the drug. This is an interesting case because the proarrhthmia of the drug was not tachyarrhythmia, such as ventricular tachycardia or torsades de pointes, but sinus pause. (+info)Early predictors of 30-day mortality in supratentorial ischemic stroke patients--first episode. (5/148)
INTRODUCTION: Prognostic factors following stroke remain to be established. The aim of this study was to determine early prognostic factors related with a 30-day mortality in first episode ischemic stroke patients. MATERIALS AND METHODS: The study group comprised 329 consecutive patients, aged between 33 and 99 years (mean age +/- SD 69 +/- 12.6) admitted within 24 hours following their first supratentorial ischemic stroke, confirmed either by computer tomography (CT) and/or autopsy. The following data were assessed within 24 hours of hospitalization: gender, age, history of diabetes mellitus, history of ischemic heart disease, obesity, the neurological deficit at entry and after one day, level of consciousness at entry and after one day, electrocardiographic dysrhythmia at entry, blood pressure at entry and body temperature on the first day following stroke. We also assessed particular serum biochemical and hematological markers including: hematocrit, fibrinogen concentration, platelet count, white blood cell (WBC) count, gamma globulin level, glucose level, cholesterol level, the erythrocyte sedimentation rate (ESR), and creatinine kinase (CK) level. The end-point for assessment was early death (within 30 days). Statistical analysis consisted of univariate analysis and multiple regression. RESULTS: Univariate analysis demonstrated that an older age, increased neurological deficit at entry and on the next day, decreased consciousness at entry and on the next day, electrocardiographic dysrhythmia, increased body temperature and glucose level, decreased cholesterol level and increased CK level were significantly associated with death after 30 days (p < or = 0.05). During multivariate analysis, only a severe neurological deficit (Scandinavian Stroke Scale < or = 15 points) both at entry and on the next day (OR = 8.3; 95% CI: 2.83-24.35), decreased consciousness within the first 24 hours of hospitalization (OR = 19.2; 95% CI: 2.84-127.77) and electrocardiographic dysrhythmia (OR = 5.2; 95% CI: 2.37-13.77) were associated with death after 30 days. CONCLUSION: A severe neurological deficit lasting 24 hours, decreased consciousness within 24 hours of hospitalization and electrocardiographic dysrhythmia are the most important indicators of 30-day mortality in patients with first-time ischemic stroke. (+info)Rhinospirography in evaluation of respiratory disorders in patients with central nervous system tumors. (6/148)
The aim of the study was to define respiratory disorders caused by central nervous system tumors. We investigated 51 patients (31 men, 20 women, mean age 58). They were divided into the following groups: patients with supra-, infratentorial and cranio-vertebral junction lesions. We analyzed: the localization of tumors based on CT and MRI examinations and intraoperative observation, the status of consciousness by GCS scale, neurological status and histological findings. For the estimation of dynamics of the respiratory changes, rhinospirography examination was repeated several times in the course of observation. The alterations of respiration were clearly visible in many cases. We have confirmed that respiratory disorders found by rhinospirography provide a source of important clinical information on the effect of the treatment and prognosis. We have also confirmed that changes in respiration are observed earlier than changes of consciousness. (+info)Measuring plasma paracetamol concentrations in all patients with drug overdose or altered consciousness: does it change outcome? (7/148)
OBJECTIVE: To assess whether measuring plasma paracetamol concentrations in all patients with drug overdose or collapse (altered consciousness) changes outcome. METHOD: A retrospective survey was performed of all patients attending the Accident and Emergency Department at Guy's Hospital, London over a 12 month period who had plasma paracetamol concentrations measured (it is hospital policy that patients presenting after any drug overdose, or with a collapse/altered consciousness have a plasma paracetamol concentration). RESULTS: A total of 440 patients were identified who had plasma paracetamol concentrations measured, of whom 411 were eligible for the study. Altogether 115 patients presented after a collapse and paracetamol was detected in four of these. A total of 296 patients presented after a drug overdose-136 denied overdose with a paracetamol containing product and paracetamol was not detected in any of these 136 cases. Of the remaining 160 patients who gave a positive history for overdose with paracetamol, 122 presented within 24 hours and 94 had detectable paracetamol values with 16 cases above the treatment line, 12 presented more than 24 hours after ingestion, and 26 presented with a staggered overdose. One patient died as a result of paracetamol overdose. CONCLUSIONS: This is the first study in the United Kingdom to evaluate the clinical value of routine paracetamol levels in patients presenting to the emergency department after any overdose or a collapse. Taking blood samples for plasma paracetamol estimation in patients who deny taking paracetamol is of little clinical value. However, there is the potential for missing significant paracetamol poisoning in patients presenting with collapse and so screening with a plasma paracetamol concentration is clinically justified in these patients. Such an approach can only be justified in a country in which paracetamol poisoning is prevalent, such as the United Kingdom. (+info)Type II (adult onset) citrullinaemia: clinical pictures and the therapeutic effect of liver transplantation. (8/148)
OBJECTIVE: Adult onset type II citrullinemia is an inherited disorder of amino acid metabolism caused by a deficiency of liver specific argininosuccinate synthetase activity. Most of the patients with this disease were reported in Japan and therefore, this disease has not been well recognised outside this country. The detailed clinical pictures of the patients with type II citrullinaemia are reported and their outcomes after liver transplantation referred to. METHODS: Ten patients with this disease were evaluated. Seven of them underwent liver transplants using a graft obtained from a healthy family member. RESULTS: There were six men and four women; the age of onset of encephalopathy ranged from 17 to 51 years. The initial symptom in nine patients was sudden onset disturbance of consciousness, and one patient had long been regarded as having a chronic progressive psychotic illness. High concentrations of plasma citrulline and ammonia were commonly seen on admission. Although brain CT or MRI lacked any consistent findings, the EEG was abnormal in all patients, showing diffuse slow waves. Additionally, in five patients chronic pancreatitis preceded the onset of encephalopathy. After liver transplantation the metabolic abnormalities, including abnormal plasma concentrations of citrulline and ammonia, were immediately corrected and all neuropsychic symptoms soon disappeared, except for impaired cognitive function in one patient. Six out of these seven patients returned to their previous social lives, including work. CONCLUSIONS: The clinical concept of adult onset type II citrullinaemia coincides well with the range of hepatic encephalopathy, and liver transplantation is a very promising therapeutic approach. (+info)Consciousness disorders refer to a range of conditions that affect an individual's level of awareness, attention, and responsiveness to their environment. These disorders can be caused by a variety of factors, including brain injury, brain disease, metabolic imbalances, and drug or alcohol intoxication. Some common types of consciousness disorders include: 1. Coma: A state of prolonged unconsciousness in which a person is unresponsive to their environment and cannot be awakened. 2. Vegetative state: A condition in which a person is awake but unresponsive to their environment, with no evidence of awareness or consciousness. 3. Minimally conscious state: A condition in which a person is awake but has only minimal awareness or responsiveness to their environment. 4. Delirium: A state of acute confusion and disorientation that can occur as a result of a variety of medical conditions, including infections, medications, and brain injury. 5. Amnesia: A condition in which a person has difficulty forming new memories or recalling existing ones. Consciousness disorders can be difficult to diagnose and treat, as they often require a thorough evaluation of a person's neurological function and medical history. Treatment may involve medications, physical therapy, and other interventions, depending on the underlying cause of the disorder.
In the medical field, consciousness refers to an individual's awareness of their surroundings, thoughts, and emotions. It is the subjective experience of being awake and aware of one's environment, thoughts, and feelings. Consciousness is often assessed through various clinical measures, such as the Glasgow Coma Scale, which evaluates a patient's level of consciousness based on their eye opening, verbal response, and motor response to stimuli. Consciousness is a complex and multifaceted phenomenon that is not yet fully understood by scientists. It is thought to involve the activity of various brain regions, including the prefrontal cortex, thalamus, and brainstem. Disorders of consciousness, such as coma, vegetative state, and minimally conscious state, can result from damage to these brain regions and can have significant implications for a patient's quality of life and prognosis.
In the medical field, unconsciousness refers to a state of altered mental awareness in which a person is not aware of their surroundings, unable to respond to stimuli, and unable to communicate. This can occur due to a variety of factors, including head injury, stroke, drug overdose, or lack of oxygen to the brain. During unconsciousness, a person may appear to be asleep, but they are not responding to attempts to wake them up. They may also have abnormal muscle tone, such as rigidity or flaccidity, and their breathing and heart rate may be altered. Unconsciousness can be classified into different levels, ranging from mild sedation to deep coma. The level of unconsciousness can be assessed using various tools, such as the Glasgow Coma Scale, which evaluates a person's eye opening, verbal response, and motor response. Treatment for unconsciousness depends on the underlying cause and may involve medications, surgery, or supportive care to maintain vital functions. In some cases, unconsciousness may be a temporary state, while in others, it may be a permanent condition.
A Persistent Vegetative State (PVS) is a medical condition in which a person is in a coma-like state and has no awareness of their surroundings or ability to communicate. The person's brainstem and brainstem reflexes are intact, but higher brain functions such as consciousness, awareness, and communication are lost. In a PVS, a person's eyes may be open, but they do not respond to visual stimuli or follow objects with their eyes. They may also have some basic reflexes, such as swallowing and coughing, but they do not have any voluntary movements or responses to touch or sound. A PVS is often caused by severe brain injury, such as a stroke, head trauma, or infection. It can also be caused by certain medical conditions, such as encephalitis or anoxia. The diagnosis of PVS is typically made by a team of medical professionals, including neurologists, neurosurgeons, and neuropsychologists. Treatment for PVS typically involves supportive care, such as nutrition and hydration, and may include physical therapy and rehabilitation to maintain muscle tone and prevent complications such as pneumonia or pressure ulcers.
In the medical field, a coma is a state of prolonged unconsciousness in which a person is unresponsive to their environment and cannot be awakened. Comas can be caused by a variety of factors, including head injuries, brain infections, drug overdose, and certain medical conditions such as stroke or heart attack. During a coma, a person's brain activity is significantly reduced, and they may show little to no signs of awareness or responsiveness. They may also experience changes in their vital signs, such as a slower heart rate and lower blood pressure. The duration of a coma can vary widely, from a few hours to several weeks or even months. In some cases, a person may emerge from a coma with no lasting effects, while in other cases, they may experience permanent brain damage or disability. Treatment for a coma typically involves addressing the underlying cause and providing supportive care to help the person's body recover.
Bipolar disorder, also known as manic-depressive illness, is a mental health condition characterized by extreme mood swings that include episodes of mania or hypomania (abnormally elevated or irritable mood) and depression. These mood swings can be severe and can significantly impact a person's daily life, relationships, and ability to function. Bipolar disorder is typically diagnosed based on a person's symptoms, medical history, and a physical examination. There are several different types of bipolar disorder, including bipolar I disorder, bipolar II disorder, cyclothymic disorder, and other specified bipolar and related disorders. Treatment for bipolar disorder typically involves a combination of medication and therapy. Medications used to treat bipolar disorder may include mood stabilizers, antipsychotics, and antidepressants. Therapy may include cognitive-behavioral therapy, interpersonal and social rhythm therapy, and family-focused therapy. It is important to note that bipolar disorder is a serious medical condition that requires ongoing treatment and management. With proper treatment, many people with bipolar disorder are able to manage their symptoms and lead fulfilling lives.
In the medical field, mental disorders are conditions that affect a person's thoughts, feelings, and behaviors, causing significant distress or impairment in daily functioning. Mental disorders are diagnosed based on a set of criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which is published by the American Psychiatric Association. The DSM-5 categorizes mental disorders into several broad categories, including: 1. Anxiety disorders: conditions characterized by excessive fear or worry, such as generalized anxiety disorder, panic disorder, and social anxiety disorder. 2. Mood disorders: conditions characterized by significant changes in mood, such as major depressive disorder, bipolar disorder, and dysthymia. 3. Schizophrenia spectrum and other psychotic disorders: conditions characterized by delusions, hallucinations, disorganized thinking, and abnormal behavior, such as schizophrenia, schizoaffective disorder, and delusional disorder. 4. Neurodevelopmental disorders: conditions that begin in childhood and affect cognitive and social development, such as autism spectrum disorder and attention-deficit/hyperactivity disorder (ADHD). 5. Personality disorders: conditions characterized by enduring patterns of thoughts, feelings, and behaviors that deviate from societal norms and cause significant distress or impairment, such as borderline personality disorder, narcissistic personality disorder, and antisocial personality disorder. 6. Substance-related and addictive disorders: conditions characterized by the use of substances or behaviors that cause significant impairment in daily functioning, such as alcohol use disorder, opioid use disorder, and gambling disorder. 7. Eating disorders: conditions characterized by abnormal eating behaviors that cause significant distress or impairment, such as anorexia nervosa, bulimia nervosa, and binge eating disorder. Mental disorders can be caused by a combination of genetic, environmental, and psychological factors, and they can have a significant impact on a person's quality of life. Treatment for mental disorders typically involves a combination of medication, therapy, and lifestyle changes.
Propofol is a medication that is commonly used in the medical field for anesthesia. It is a short-acting sedative-hypnotic drug that is administered intravenously to induce and maintain general anesthesia. Propofol works by binding to specific receptors in the brain, which leads to a loss of consciousness and muscle relaxation. It is often used in combination with other anesthetic drugs and is also used to manage pain and anxiety in intensive care units and during medical procedures. Propofol is a powerful drug and can cause serious side effects if not administered properly, so it is typically only used by trained medical professionals in a controlled setting.
Anxiety disorders are a group of mental health conditions characterized by excessive and persistent feelings of worry, fear, and unease. These disorders can interfere with a person's daily life, relationships, and ability to function normally. Anxiety disorders can be classified into several categories, including generalized anxiety disorder, panic disorder, social anxiety disorder, specific phobia, and obsessive-compulsive disorder (OCD). Treatment for anxiety disorders typically involves a combination of medication and therapy, such as cognitive-behavioral therapy (CBT).
Mood disorders are a group of mental health conditions characterized by significant disturbances in mood, emotions, and behavior. These disorders are typically classified into two main categories: depressive disorders and bipolar disorders. Depressive disorders include major depressive disorder (MDD), persistent depressive disorder (PDD), and dysthymia. These disorders are characterized by persistent feelings of sadness, hopelessness, and loss of interest in activities that were once enjoyable. Symptoms may also include changes in appetite and sleep patterns, fatigue, and difficulty concentrating. Bipolar disorders, on the other hand, are characterized by extreme mood swings that alternate between periods of mania or hypomania (elevated or irritable mood, increased energy, and decreased need for sleep) and periods of depression. The most common bipolar disorder is bipolar I disorder, which is characterized by at least one manic episode, while bipolar II disorder is characterized by at least one hypomanic episode and one major depressive episode. Other mood disorders include seasonal affective disorder (SAD), which is a type of depression that occurs during the winter months, and premenstrual dysphoric disorder (PMDD), which is a severe form of premenstrual syndrome (PMS) that affects mood and behavior. Mood disorders can have a significant impact on a person's quality of life, relationships, and ability to function in daily activities. Treatment typically involves a combination of medication, psychotherapy, and lifestyle changes.
Intravenous anesthetics are medications that are administered directly into a patient's bloodstream through a vein to induce anesthesia. These medications work by altering the patient's consciousness and reducing their awareness of pain and other sensations during surgery or other medical procedures. There are several types of intravenous anesthetics, including: 1. Barbiturates: These medications are commonly used to induce anesthesia and to maintain anesthesia during surgery. They work by slowing down the central nervous system and reducing consciousness. 2. Benzodiazepines: These medications are often used in combination with other anesthetics to reduce anxiety and to produce a deeper level of anesthesia. 3. Propofol: This medication is commonly used to induce anesthesia and to maintain anesthesia during surgery. It works by slowing down the central nervous system and reducing consciousness. 4. Ketamine: This medication is often used to induce anesthesia in emergency situations or in patients who are difficult to anesthetize. It works by altering the patient's perception of pain and reducing their awareness of their surroundings. Intravenous anesthetics are typically administered by a trained healthcare professional, such as an anesthesiologist or a nurse anesthetist, in a hospital or surgical setting. The dosage and type of anesthetic used will depend on the patient's age, weight, medical history, and the type of procedure being performed.
In the medical field, "Consciousness Monitors" refer to devices or systems used to assess a patient's level of consciousness. These monitors are typically used in critical care settings, such as intensive care units (ICUs), to continuously monitor a patient's level of consciousness and provide real-time feedback to healthcare providers. There are several types of consciousness monitors, including: 1. Glasgow Coma Scale (GCS): A standardized tool used to assess a patient's level of consciousness by evaluating their eye opening, verbal response, and motor response. 2. Brain Function Monitoring (BFM): A non-invasive technique that uses electrodes placed on the scalp to measure electrical activity in the brain. This can help detect changes in brain function that may indicate changes in consciousness. 3. Near-Infrared Spectroscopy (NIRS): A non-invasive technique that uses near-infrared light to measure changes in blood flow and oxygenation in the brain. This can help detect changes in brain function that may indicate changes in consciousness. 4. Functional MRI (fMRI): A non-invasive imaging technique that uses magnetic fields and radio waves to measure changes in blood flow in the brain. This can help detect changes in brain function that may indicate changes in consciousness. Overall, consciousness monitors are an important tool in the medical field for assessing and monitoring a patient's level of consciousness, particularly in critical care settings.
Disorders of consciousness
Depersonalization-derealization disorder
Dissociative disorder
Stress-related disorders
Consciousness
Network neuroscience
Neuroethics
Edmund Rolls
Brain-computer interface
Clouding of consciousness
Psychedelic treatments for trauma-related disorders
Complex post-traumatic stress disorder
Complications of traumatic brain injury
Minimally conscious state
Body image (neuroscience)
Executive dysfunction
Folie à deux
Occupational lung disease
Do not resuscitate
Philip David Zelazo
John Pickard (neurosurgeon)
Adrian Owen
Affect consciousness
Jana Iverson
Hal Blumenfeld
Mary K. Rothbart
Neuroscience
Other specified dissociative disorder
Altered level of consciousness
Ken A. Paller
Psychedelic Treatment for Consciousness Disorders? - Dana Foundation
Characterization and monitoring of vigilance fluctuation in disorders of consciousness | ADOC | Project | Fact sheet | H2020 |...
Sleep in patients with disorders of consciousness characterized by means of machine learning | PLOS ONE
Consciousness - Brain, Spinal Cord, and Nerve Disorders - Merck Manuals Consumer Version
Overview of Coma and Impaired Consciousness - Neurologic Disorders - MSD Manual Professional Edition
Circadian Body Temp Linked to Consciousness After Brain Injury
Raw data-Multimodal neuroimaging approach to variability of functional connectivity in disorders of consciousness. A PET/MRI...
Disorders of consciousness | MedLink Neurology
Practice resources
Wernicke Korsakoff syndrome - Disorders of consciousness and memory
Prolonged disorders of consciousness following sudden onset brain inju - RCP London
Neural correlates of consciousness - Scholarpedia
YNNN Fyraftensmøde: Disorders of consciousness - The acute and chronic course - Yngre Neurologer, Neurokirurger og...
Functional neuroanatomy of altered states of consciousness: the transient hypofrontality hypothesis
Dissociative Identity Disorder: How I Manage
Courageously Raising Consciousness About Body Image and Eating Disorders | The Nurse Keith Show, EPS 338 | Nurse Keith
Medication - wikidoc
Pediatric Conversion Disorder: Overview, Background and Nomenclature, Diagnostic Criteria
Disruptions in effective connectivity within and between default mode network and anterior forebrain mesocircuit in prolonged...
A problem shared is a problem halved? Comparing burdens arising for family caregivers of patients with disorders of...
Krabbe disease: MedlinePlus Medical Encyclopedia
Table 1 - Severe Leptospirosis in Hospitalized Patients, Guadeloupe - Volume 16, Number 2-February 2010 - Emerging Infectious...
Electrophysiological evidence of preserved hearing at the end of life | Scientific Reports
Clinical Neurology MSc | 2024 | Postgraduate
Frontiers | Functional Connectivity Substrates for tDCS Response in Minimally Conscious State Patients
Simple 'sniff test' reliably predicts recovery of severely brain-injured patients | University of Cambridge
Waking the unconscious: the latest science on awakenings | TIME.com
Docs on the Move: Jernejcic to Lead Trailblazing Hospital in China
Cerebral Aneurysms | National Institute of Neurological Disorders and Stroke
What is Consciousness? - Spirituality meets Quantum Physics | Udemy
Coma4
- The mechanism for coma or impaired consciousness involves dysfunction of both cerebral hemispheres or of the reticular activating system (also known as the ascending arousal system). (msdmanuals.com)
- Investigators assessed patients by using the Coma Recovery Scale-Revised (CRS-R), a behavioral assessment tool for patients' consciousness levels, which consists of 23 items in six subscales that address auditory, visual, motor, oromotor, communication, and arousal functions. (medscape.com)
- Patients with VS/UWS and MCS have severe brain damage who survive initial periods of coma (usually 1 to 3 weeks), can maintain brainstem functions, do not require mechanical respiratory support, and redevelop sleep-wake cycles, including prolonged periods of eye-opening, but have no (vegetative state) or intermittent but definite clinical evidence of consciousness (MCS). (medlink.com)
- Coma is a complete loss of consciousness in which the eyes remain closed and there are no sleep-wake cycles. (time.com)
Cognitive4
- The content of consciousness depends on mental (cognitive) function and involves understanding and processing what is experienced and encountered. (merckmanuals.com)
- Cognitive-motor dissociation has been shown to occur in approximately 15% to 20% of clinically unresponsive patients with both acute and chronic disorders of consciousness. (medlink.com)
- Using an evolutionary approach, consciousness is conceptualized as hierarchically ordered cognitive function. (nih.gov)
- The hallmark of altered states of consciousness is the subtle modification of behavioral and cognitive functions that are typically ascribed to the prefrontal cortex. (nih.gov)
Patients22
- The proposal to use psychedelics as a treatment for patients with consciousness disorders is based on the theoretical concept of brain complexity . (dana.org)
- From this, it follows that psychedelics might increase brain complexity in patients with consciousness disorders, leading to heightened levels of conscious awareness. (dana.org)
- In a forthcoming paper, bioethicist Andrew Peterson of George Mason University and his colleagues discuss the ethics of using psychedelic drugs on patients with consciousness disorders. (dana.org)
- This prospective exploratory study will aim at characterizing vigilance fluctuation in patients with disorders of consciousness (as defined by a change in diurnal behavioral response over time) using neurophysiological parameters. (europa.eu)
- A new study shows that circadian body temperature rhythms are related to the level of consciousness in patients with a severe brain injury. (medscape.com)
- The results suggest that circadian rhythm may represent a therapeutic target in patients who have a disorder of consciousness (DOC). (medscape.com)
- However, functional neuroimaging and electrophysiological studies suggest that some degree of consciousness or awareness that has not been or could not be determined by behavioral evaluations alone may be present in some of these patients who, hence, have covert consciousness. (medlink.com)
- Functional neuroimaging and electrophysiological technologies may indicate consciousness through neural correlates, surrogates, or proxies in patients without behavioral evidence of consciousness owing to loss of appropriate motor function. (medlink.com)
- Prolonged recovery in patients with disorders of consciousness is not infrequent, particularly in minimally conscious state patients, and most patients may benefit from continued aggressive physical therapies. (medlink.com)
- The advent of modern intensive care in the 1960s allowed for continuing and prolonged cardiorespiratory support of critically ill patients, one consequence of which was recognition of various clinical disorders of consciousness. (medlink.com)
- These disorders of consciousness are often temporary evolutionary syndromes that exist on a continuum, with some patients transitioning sequentially from VS/UWS to MCS and then, possibly, to higher states of consciousness. (medlink.com)
- A particular burden arises from the care for patients with disorders of consciousness (DOC). (biomedcentral.com)
- Given the wide range of prevalence data, in addition to the fact that neither study included patients being taken care of at home, the actual prevalence of these disorders remains basically unknown. (biomedcentral.com)
- Transcranial direct current stimulation (tDCS) is a non-invasive technique recently employed in disorders of consciousness, and determining a transitory recovery of signs of consciousness in almost half of minimally conscious state (MCS) patients. (frontiersin.org)
- Our findings suggest that a prior high connectivity with regions belonging to ECN can facilitate transitory recovery of consciousness in a subgroup of MCS patients that underwent tDCS treatment. (frontiersin.org)
- Moreover, although the efforts spent to identify patients that could emerge from this state and recover consciousness (e.g. (frontiersin.org)
- A simple, inexpensive 'sniff test' could help doctors to accurately diagnose and determine treatment plans for patients with disorders of consciousness. (cam.ac.uk)
- It found that 100% of patients who reacted to the sniff test went on to regain consciousness, and over 91% of these patients were still alive three and a half years after injury. (cam.ac.uk)
- This new and simple method to assess the likelihood of recovery should be immediately incorporated in the diagnostic tools for patients with disorders of consciousness. (cam.ac.uk)
- Though Ambien won't have the same effect on most patients with impaired consciousness, it can help an estimated one in 15, according to one small-scale trial published in 2009. (time.com)
- Patients may recover or progress to another disorder of consciousness. (time.com)
- The Questionnaire is useful for investigating alcohol consumption in patients with schizoaffective disorder. (medscape.com)
Brain9
- Scientists here and elsewhere are busy studying how psychedelics affect the brain and conducting human clinical trials testing their efficacy as treatments for everything from treatment-resistant depression to post-traumatic stress disorder (PTSD). (dana.org)
- Disorders of consciousness typically occur following severe acquired traumatic brain injury that disrupts the brain systems involved in arousal and conscious awareness. (dana.org)
- Some theorists link measures of brain complexity to levels of conscious awareness , and predict that complexity should be at high levels during the normal waking state and lower in states in which consciousness is lost. (dana.org)
- Secondary brain ischemia may affect the RAS or both cerebral hemispheres, impairing consciousness. (msdmanuals.com)
- The causes of disorders of consciousness include traumatic brain injuries, diffuse cerebral ischemia or hypoxia as can follow cardiac arrest, or cerebral infarction or hemorrhage. (medlink.com)
- A science of consciousness must strive to explain the exact relationship between phenomenal, mental states and brain states. (scholarpedia.org)
- Brain scientists are exploiting a number of empirical approaches to shed light on the neural basis of consciousness. (scholarpedia.org)
- The above definition of Neural Correlates of Consciousness stresses the attribute minimal because the entire brain is clearly sufficient to give rise to consciousness. (scholarpedia.org)
- It is often difficult for doctors to determine a patient's state of consciousness after a severe brain injury. (cam.ac.uk)
Lethargy1
- Less severely impaired levels of consciousness are often labeled as lethargy or, if more severe, obtundation. (msdmanuals.com)
Term consciousness1
- There are two common, but quite distinct, usages of the term consciousness, one revolving around arousal and states of consciousness and another one around the content of consciousness and conscious states . (scholarpedia.org)
Psychiatric1
- Conversion disorder is included in a newly defined category in the fifth edition of the American Psychiatric Association's (APA) Diagnostic and Statistical Manual of Mental Disorders (DSM-5) called Somatic Symptom and Related Disorders. (medscape.com)
Neuroscience2
- The paper , published in the journal Neuroscience of Consciousness this month, includes a list of questions which they hope would help guide such a trial. (dana.org)
- The present paper analyzes processes involved in these deficiencies through both naturalistic and constructivist approaches in areas such as Philosophy, Neuroscience, Child Development and Autistic Disorder. (bvsalud.org)
Symptoms4
- One of the reasons DID is so hard to diagnose is because it shares a lot of symptoms with other disorders. (healthline.com)
- Until the fourth edition ( DSM-IV ), somatoform disorders were characterized by persistent physical symptoms without an identifiable medical or physiologic explanation and symptoms that were supposed to be linked to psychological factors or conflicts. (medscape.com)
- However, when physical symptoms are persistent and a child's functioning deteriorates, a somatic symptom disorder can be considered. (medscape.com)
- Contact your provider if your child develops symptoms of this disorder. (medlineplus.gov)
Functional3
- Raw data-Multimodal neuroimaging approach to variability of functional connectivity in disorders of consciousness. (mendeley.com)
- Although this implies a holistic approach to consciousness, such a functional hierarchy localizes the most sophisticated layers of consciousness in the zenithal higher-order structure: the prefrontal cortex. (nih.gov)
- Recent research indicates prolonged disorders of consciousness (PDOC) result from structural and functional impairments to key cortical and subcortical networks, including the default mode network (DMN) and the anterior forebrain mesocircuit (AFM). (birmingham.ac.uk)
Abnormal1
- Other signs include ptosis, abnormal pupillary reactions and altered consciousness. (brainkart.com)
Occur1
- At the same time, arousal is necessary for consciousness to occur. (medscape.com)
Insights2
- This module provides practical exposure to expert specialist clinics in conditions such as TIA, stroke and epilepsy, in combination with lectures covering key aspects of these disorders and recent research insights. (sheffield.ac.uk)
- The study, published in the new journal eLife , is part of a surge of new research that provides insights into what doctors call "disorders of consciousness" and could potentially lead some of those trapped in these states to function more fully on their own. (time.com)
Neural10
- Figure 1: The Neuronal Correlates of Consciousness (NCC) are the minimal set of neural events and structures - here synchronized action potentials in neocortical pyramidal neurons - sufficient for a specific conscious percept or a conscious (explicit) memory . (scholarpedia.org)
- The Neural Correlates of Consciousness (NCC) can be defined as the minimal neuronal mechanisms jointly sufficient for any one specific conscious percept (Crick & Koch 1990). (scholarpedia.org)
- For instance, it is likely that neural activity in the cerebellum does not underlie any conscious perception, and thus is not part of the Neural Correlates of Consciousness. (scholarpedia.org)
- Every phenomenal, subjective state will have associated Neural Correlates of Consciousness: one for seeing a red patch, another one for seeing grandmother, yet a third one for hearing a siren, etc. (scholarpedia.org)
- Perturbing or inactivating the Neural Correlates of Consciousness for any one specific conscious experience will affect the percept or cause it to disappear. (scholarpedia.org)
- If the Neural Correlates of Consciousness could be induced artificially, for instance by cortical microstimulation in a prosthetic device or during neurosurgery, the subject would experience the associated percept. (scholarpedia.org)
- What are the communalities between the Neural Correlates of Consciousness for seeing and for hearing? (scholarpedia.org)
- Will the Neural Correlates of Consciousness involve all pyramidal neurons in cortex at any given point in time? (scholarpedia.org)
- It should be noted that discovering and characterizing the Neural Correlates of Consciousness in brains is not the same as a theory of consciousness . (scholarpedia.org)
- However, understanding the Neural Correlates of Consciousness is a necessary step toward such a theory. (scholarpedia.org)
Post-traumati1
- I have been formally diagnosed with dissociative identity disorder (DID) and post-traumatic stress disorder (PTSD) . (healthline.com)
Classification2
- Disorders of consciousness: Classification, diagnostics, and epidemiology. (ynnn.dk)
- Schizoaffective disorder can be defined according to either Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition ( DSM-5 ) , criteria (see below) or International Classification of Diseases, Tenth Revision ( ICD-10 ) coding. (medscape.com)
Chronic1
- A dissociative disorder is when dissociation becomes a chronic reaction to one or more traumas. (healthline.com)
Wakefulness1
- Impaired wakefulness is often called impaired consciousness. (merckmanuals.com)
Loss1
- Drinking alcohol whilst taking Vendal retard may make you feel more sleepy or increase the risk of serious side effects such as shal ow breathing with a risk of stopping breathing, and loss of consciousness. (who.int)
Cerebral3
- Therefore, the mechanism of impaired consciousness must involve both cerebral hemispheres or dysfunction of the RAS. (msdmanuals.com)
- unilateral cerebral hemisphere disorders are not sufficient, although they may cause severe neurologic deficits. (msdmanuals.com)
- However, rarely, a unilateral massive hemispheric focal lesion (eg, left middle cerebral artery stroke) impairs consciousness if the contralateral hemisphere is already compromised or if it results in compression of the contralateral hemisphere (eg, by causing edema). (msdmanuals.com)
Diurnal1
- In healthy individuals, consciousness varies rhythmically with the sleep-wake cycle, during which behaviorally detectable consciousness fades and recovers on a diurnal basis. (medscape.com)
Digestive1
- The Chengdu hospital will encompass patient-focused centers of excellence for cancer care, orthopedics, sports medicine, neurology and neurosurgery, heart and vascular treatments, ophthalmology, and digestive disorders, which will be integrated into UPMC's global network. (medscape.com)
Research3
- In April 2019, Imperial College London launched the world's first Centre for Psychedelic Research , and in September, Johns Hopkins University launched its own for Psychedelic and Consciousness Research . (dana.org)
- Earlier this year, Robin Carhart-Harris, director of the Centre for Psychedelic Research at Imperial, and his colleague Gregory Scott, proposed using psilocybin - the psychoactive ingredient found in 'magic' mushrooms - as a treatment for disorders of consciousness . (dana.org)
- Disorders of Consciousness: Evolving Research on Prognosis and Treatment. (ynnn.dk)
Bipolar1
- In the past, I was incorrectly diagnosed with borderline personality disorder (BPD), attention deficit hyperactivity disorder (ADHD), and bipolar disorder before we discovered that I had DID. (healthline.com)
Nervous1
- Krabbe disease is a rare genetic disorder of the nervous system. (medlineplus.gov)
Peripheral1
- Katirji B. Disorders of peripheral nerves. (medlineplus.gov)
Suffer2
Depends1
- Selection of medications to treat schizoaffective disorder depends on whether the depressive or manic subtype is present. (medscape.com)
Level2
- Obtundation is a reduced level of alertness or consciousness. (msdmanuals.com)
- When the sniff response is functioning normally it shows that the patient might still have some level of consciousness even when all other signs are absent," said Dr Tristan Bekinschtein in the University of Cambridge's Department of Psychology, who was involved in the study. (cam.ac.uk)
Diagnosis3
- Introduction Diagnosis of infantile thiamine deficiency disorders (TDD) is challenging due to the non-specific, highly variable clinical presentation, often leading to misdiagnosis. (bmj.com)
- The diagnosis of schizoaffective disorder is made when the patient has features of both schizophrenia and a mood disorder but does not strictly meet diagnostic criteria for either alone. (medscape.com)
- Psychological testing (eg, Structured Clinical Interview for Axis I DSM-IV Disorders [SCID-1]) is warranted to assist with diagnosis. (medscape.com)
Diagnostic Criteria1
- The first step in evaluation is to obtain a complete medical history, keeping in mind the diagnostic criteria for schizoaffective disorder. (medscape.com)
Mental7
- It is the central hypothesis of this paper that the mental states commonly referred to as altered states of consciousness are principally due to transient prefrontal cortex deregulation. (nih.gov)
- DID has a reputation for being the most difficult mental disorder to diagnose. (healthline.com)
- Disorders-of-consciousness (DOC) are rare conditions leading to very severe physical and mental disabilities. (biomedcentral.com)
- Around the same time, Myers and Janet developed psychological frameworks for understanding "psychological automatisms," which emphasized the coexistence of separate mental systems that would normally be integrated into person's consciousness, identity, and physical self. (medscape.com)
- Schizoaffective disorder is a perplexing mental illness that has both features of schizophrenia and features of a mood disorder. (medscape.com)
- Organic mental disorders in which there is impairment of the ability to maintain awareness of self and environment and to respond to environmental stimuli. (bvsalud.org)
- Manual of Mental Disorders ( 3 ). (who.int)
State2
- Consciousness is a puzzling, state-dependent property of certain types of complex , biological, adaptive, and highly interconnected systems. (scholarpedia.org)
- Alterations in the state of consciousness. (who.int)
Treatment1
- Psychedelic Treatment for Consciousness Disorders? (dana.org)