A comprehensive map of the physical interconnections of an organism's neural networks. This modular organization of neuronal architecture is believed to underlie disease mechanisms and the biological development of the CENTRAL NERVOUS SYSTEM.
Birth defect that results in a partial or complete absence of the CORPUS CALLOSUM. It may be isolated or a part of a syndrome (e.g., AICARDI'S SYNDROME; ACROCALLOSAL SYNDROME; ANDERMANN SYNDROME; and HOLOPROSENCEPHALY). Clinical manifestations include neuromotor skill impairment and INTELLECTUAL DISABILITY of variable severity.
A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.
Neural tracts connecting one part of the nervous system with another.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
The most common clinical form of FRONTOTEMPORAL LOBAR DEGENERATION, this dementia presents with personality and behavioral changes often associated with disinhibition, apathy, and lack of insight.
An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.
Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.
A form of MACULAR DEGENERATION also known as dry macular degeneration marked by occurrence of a well-defined progressive lesion or atrophy in the central part of the RETINA called the MACULA LUTEA. It is distinguishable from WET MACULAR DEGENERATION in that the latter involves neovascular exudates.
A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)
Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surface-based atlases. (1/116)

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Cortical parcellations of the macaque monkey analyzed on surface-based atlases. (2/116)

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The anatomical distance of functional connections predicts brain network topology in health and schizophrenia. (3/116)

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Functional organization of the neural language system: dorsal and ventral pathways are critical for syntax. (4/116)

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Identifying behavioral circuits in Drosophila melanogaster: moving targets in a flying insect. (5/116)

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Functional connectivity measured with magnetoencephalography identifies persons with HIV disease. (6/116)

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The Human Connectome Project: a data acquisition perspective. (7/116)

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Building retinal connectomes. (8/116)

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TY - JOUR. T1 - Connectome organization is related to longitudinal changes in general functioning, symptoms and IQ in chronic schizophrenia. AU - Collin, G.. AU - de Nijs, J.. AU - Hulshoff Pol, H. E.. AU - Cahn, W.. AU - van den Heuvel, M. P.. PY - 2016/6/1. Y1 - 2016/6/1. N2 - Emerging evidence suggests schizophrenia to involve widespread alterations in the macroscale wiring architecture of the human connectome. Recent findings of attenuated connectome alterations in unaffected siblings of schizophrenia patients suggest that altered connectome organization may relate to the vulnerability to develop the disorder, but whether it relates to progression of illness after disease onset is currently unknown. Here, we examined the interaction between connectome structure and longitudinal changes in general functioning, clinical symptoms and IQ in the 3 years following MRI assessment in a group of chronically ill schizophrenia patients. Effects in patients were compared to associations between ...
The functioning of the human brain relies on the interplay and integration of numerous individual units within a complex network. To identify network configurations characteristic of specific cognitive tasks or mental illnesses, functional connectomes can be constructed based on the assessment of synchronous fMRI activity at separate brain sites, and then analyzed using graph-theoretical concepts. In most previous studies, relatively coarse parcellations of the brain were used to define regions as graphical nodes. Such parcellated connectomes are highly dependent on parcellation quality because regional and functional boundaries need to be relatively consistent for the results to be interpretable. In contrast, dense connectomes are not subject to this limitation, since the parcellation inherent to the data is used to define graphical nodes, also allowing for a more detailed spatial mapping of connectivity patterns. However, dense connectomes are associated with considerable computational demands in
TY - JOUR. T1 - Functional connectome of the striatal medium spiny neuron. AU - Chuhma, Nao. AU - Tanaka, Kenji F.. AU - Hen, René. AU - Rayport, Stephen. PY - 2011/1/26. Y1 - 2011/1/26. N2 - Dopamine system disorders ranging from movement disorders to addiction and schizophrenia involve striatal medium spiny neurons (MSNs), yet their functional connectivity has been difficult to determine comprehensively. We generated a mouse with conditional channelrhodopsin-2 expression restricted to medium spiny neurons and assessed the specificity and strength of their intrinsic connections in the striatum and their projections to the globus pallidus and the substantia nigra. In the striatum, medium spiny neurons connected with other MSNs and tonically active cholinergic interneurons, but not with fast-spiking GABA interneurons. In the globus pallidus, medium spiny neurons connected strongly with one class of electrophysiologically identified neurons, but weakly with the other. In the substantia nigra, ...
The member universities of the Human Connectome Project take privacy very seriously, whether dealing with participant data or the data of those visiting this website. The participant data from our research into the Human Connectome that is stored in our XNAT server is de-identified, and contains no personal health information (PHI). Our website collects names and email addresses via our contact form. This information is used solely by the administrators and members of the HCP website and is not shared, traded or sold to third parties under any circumstances. Our website may also collect non-personal data about site visits, sessions, and IP addresses. This information is only used for diagnostic or debugging purposes, to help us optimize our websites performance, and is not shared externally. This is a standard practice for most websites, and this data is never linked with personally identifiable information. This website contains links to other websites whose content we think is relevant. ...
The member universities of the Human Connectome Project take privacy very seriously, whether dealing with participant data or the data of those visiting this website. The participant data from our research into the Human Connectome that is stored in our XNAT server is de-identified, and contains no personal health information (PHI). Our website collects names and email addresses via our contact form. This information is used solely by the administrators and members of the HCP website and is not shared, traded or sold to third parties under any circumstances. Our website may also collect non-personal data about site visits, sessions, and IP addresses. This information is only used for diagnostic or debugging purposes, to help us optimize our websites performance, and is not shared externally. This is a standard practice for most websites, and this data is never linked with personally identifiable information. This website contains links to other websites whose content we think is relevant. ...
The developing Human Connectome Project (dHCP) aims to create a detailed 4-dimensional connectome of early life spanning 20-45 weeks post-menstrual age. This is being achieved through the acquisition of multi-modal MRI data from over 1000 in- and ex-utero subjects combined with the development of optimised pre-processing pipelines. In this paper we present an automated and robust pipeline to minimally pre-process highly confounded neonatal resting-state fMRI data, robustly, with low failure rates and high quality-assurance. The pipeline has been designed to specifically address the challenges that neonatal data presents including low and variable contrast and high levels of head motion. We provide a detailed description and evaluation of the pipeline which includes integrated slice-to-volume motion correction and dynamic susceptibility distortion correction, a robust multimodal registration approach, bespoke ICA-based denoising, and an automated QC framework. We assess these components on a ...
The Human Connectome Project (HCP) has developed protocols, standard operating and quality control procedures, and a suite of informatics tools to enable high throughput data collection, data sharing, automated data processing and analysis, and data mining and visualization. Quality control procedures include methods to maintain data collection consistency over time, to measure head motion, and to establish quantitative modality-specific overall quality assessments. Database services developed as customizations of the XNAT imaging informatics platform support both internal daily operations and open access data sharing. The Connectome Workbench visualization environment enables user interaction with HCP data and is increasingly integrated with the HCPs database services. Here we describe the current state of these procedures and tools and their application in the ongoing HCP study. © 2013 Elsevier Inc.
Spontaneous fluctuations in activity in different parts of the brain can be used to study functional brain networks. We review the use of resting-state functional MRI (rfMRI) for the purpose of mapping the macroscopic functional connectome. After describing MRI acquisition and image-processing methods commonly used to generate data in a form amenable to connectomics network analysis, we discuss different approaches for estimating network structure from that data. Finally, we describe new possibilities resulting from the high-quality rfMRI data being generated by the Human Connectome Project and highlight some upcoming challenges in functional connectomics.
The Human Connectome Project (HCP) seeks to map the structural and functional connections between network elements in the human brain. Magnetoencephalography (MEG) provides a temporally rich source of information on brain network dynamics and represents one source of functional connectivity data to be provided by the HCP. High quality MEG data will be collected from 50 twin pairs both in the resting state and during performance of motor, working memory and language tasks. These data will be available to the general community. Additionally, using the cortical parcellation scheme common to all imaging modalities, the HCP will provide processing pipelines for calculating connection matrices as a function of time and frequency. Together with structural and functional data generated using magnetic resonance imaging methods, these data represent a unique opportunity to investigate brain network connectivity in a large cohort of normal adult human subjects. The analysis pipeline software and the dynamic
The Human Connectome Project (HCP) relies primarily on three complementary magnetic resonance (MR) methods. These are: 1) resting state functional MR imaging (rfMRI) which uses correlations in the temporal fluctuations in an fMRI time series to deduce functional connectivity; 2) diffusion imaging (dMRI), which provides the input for tractography algorithms used for the reconstruction of the complex axonal fiber architecture; and 3) task based fMRI (tfMRI), which is employed to identify functional parcellation in the human brain in order to assist analyses of data obtained with the first two methods. We describe technical improvements and optimization of these methods as well as instrumental choices that impact speed of acquisition of fMRI and dMRI images at 3T, leading to whole brain coverage with 2 mm isotropic resolution in 0.7 s for fMRI, and 1.25 mm isotropic resolution dMRI data for tractography analysis with three-fold reduction in total dMRI data acquisition time. Ongoing technical developments
Analysing computations in neural circuits often uses simplified models because the actual neuronal implementation is not known. For example, a problem in vision, how the eye detects image motion, has long been analysed using Hassenstein-Reichardt (HR) detector or Barlow-Levick (BL) models. These both simulate motion detection well, but the exact neuronal circuits undertaking these tasks remain elusive. We reconstructed a comprehensive connectome of the circuits of Drosophilas motion-sensing T4 cells using a novel EM technique. We uncover complex T4 inputs and reveal that putative excitatory inputs cluster at T4s dendrite shafts, while inhibitory inputs localize to the bases. Consistent with our previous study, we reveal that Mi1 and Tm3 cells provide most synaptic contacts onto T4. We are, however, unable to reproduce the spatial offset between these cells reported previously. Our comprehensive connectome reveals complex circuits that include candidate anatomical substrates for both HR and BL ...
Additional notes. Improved atlas surfaces and myelin maps. The Conte69 atlas dataset was derived from Freesurfer segmentation, surface reconstruction, and registration to the fsaverage left and right hemispheres, followed by interhemispheric registration to the left-right hybrid atlas, bringing the two hemispheres into geographic correspondence (Ref 1). The current data release benefits from several refinements in surface generation and in the myelin mapping algorithm compared to the published data (Refs 1, 2). Connectome Workbench data format. The Conte69 atlas dataset is also available in the new Connectome Workbench data format being developed for the Human Connectome Project. A beta-release of Connectome Workbench will be made available in the summer of 2012. REFERENCES. ...
Additional notes. Improved atlas surfaces and myelin maps. The Conte69 atlas dataset was derived from Freesurfer segmentation, surface reconstruction, and registration to the fsaverage left and right hemispheres, followed by interhemispheric registration to the left-right hybrid atlas, bringing the two hemispheres into geographic correspondence [1]. The current data release benefits from several refinements in surface generation and in the myelin mapping algorithm compared to the published data [1, 2]. Connectome Workbench data format. The Conte69 atlas dataset is also available in the new Connectome Workbench data format being developed for the Human Connectome Project. A beta-release of Connectome Workbench will be made available in the summer of 2012. REFERENCES. ...
The primate connectome, possessing a characteristic global topology and specific regional connectivity profiles, is well organized to support both segregated and integrated brain function. However, the organization mechanisms shaping the characteristic connectivity and its relationship to functional requirements remain unclear. The primate brain connectome is shaped by metabolic economy as well as functional values. Here, we explored the influence of two competing factors and additional advanced functional requirements on the primate connectome employing an optimal trade-off model between neural wiring cost and the representative functional requirement of processing efficiency. Moreover, we compared this model with a generative model combining spatial distance and topological similarity, with the objective of statistically reproducing multiple topological features of the network. The primate connectome indeed displays a cost-efficiency trade-off and that up to 67% of the connections were ...
This proposal is a continuation of our efforts to create a three-dimensional, Google Earth-like, digital Connectome atlas of the C57Black/6J mouse brain. Curren...
We interview Alastair Marriott with his work and life partner Jonathan Howells to talk choreography and neuroscience. The pair met as students at the Royal Ballet School but only began working together on professional projects recently. As choreographer, Marriott takes the lead while a work is initially developed. He explores ideas on his own before sharing them with dancers in a studio where their reactions influence the work. Once the principal shape of the choreography is determined Howells takes over and directs rehearsals. He must learn all the dancers movements and communicate Marriotts desired nuances and aesthetic. This allows to Marriott take some distance during rehearsals; keeping his eye sharp for fine-tuning.. Marriotts ballet, Connectome, explores the theory that every individual has a unique mental map that is shaped and coloured by events in their life. As a project of neuroscience, mental mapping remains largely underdeveloped so as creative stimulus it provides huge scope for ...
Recently the relation among activated human brain regions has drawn interests and has been investigated The imaging technique of functional magnetic resonance imagimg (fMRI) can be used to observe by changes in cerebral blood oxygenation and therefore brain connectivity To understand how white matter (WM) tractography influences brain connectivity we use diffusion magnetic resonance imagimg (dMRI) technique and algorithm to calculate WM map The connectivity measurement combining fMRI and dMRI datasets is called anatomically weighted functional connectivity (awFC) Finally the results show that when using awFC datasets the clusters have higher functional connectivity (FC) and structural connectivity (SC) strength when using awFC datasets ...
You are unique, just like everyone else.. Connectomics is the study of the structural and functional connections among brain cells; its product is the connectome, a detailed map of those connections. The idea is that such information will be monumental in our understanding of the healthy and diseased brain. Sebastian Seung thinks that a complete connectome of the human brain will be one of the great prizes in 21st-century neuroscience.. Efforts to construct brain connectomes are split into two categories: ones that use imaging techniques like MRI, PET, and DT, thus focusing on macroscopic connections or tracts; and those that use electron microscopy to map the tinniest of axons (0.2-20 microns in diameter) and individual synapses.. While this may sound daunting, it also seems the obvious thing to do in order to really understand how the brain works. After all, dont all our memories, personalities, and behaviors dependent on the structure of the brain, down to the microscopic level? So why is ...
TY - JOUR. T1 - The beginning of connectomics. T2 - A commentary on White et al. (1986) The structure of the nervous system of the nematode Caenorhabditis elegans. AU - Emmons, Scott W.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - The article Structure of the nervous system of the nematode Caenorhabditis elegans (aka The mind of a worm) by White et al., published for the first time the complete set of synaptic connections in the nervous system of an animal. The work was carried out as part of a programme to begin to understand how genes determine the structure of a nervous system and how a nervous system creates behaviour. It became a major stimulus to the field of C. elegans research, which has since contributed insights into all areas of biology. Twenty-six years elapsed before developments, notably more powerful computers, made new studies of this kind possible. It is hoped that one day knowledge of synaptic structure, the connectome, together with results of many other investigations, will lead ...
While maps of young adult brains will be informative, several audience members expressed interest in seeing a developmental time course of brain connectivity. At the moment, looking at younger brains or healthy older brains is beyond the scope of the project, said Story Landis, who directs the National Institute for Neurological Disorders and Stroke. If the community embraces the current database, however, future projects to look at connectivity in other populations might get funded, she added. Since equipment and infrastructure are now in place, such add-on projects would have a smaller price tag, Landis pointed out. Many researchers in the Alzheimers field have shown that brain connectivity in key regions decreases as the disease advances, making this a hot topic for AD research (see ARF related news story; ARF news story; and ARF news story).. This project will be an important step in developing connectivity methods that can be used in AD research. The methods have great potential, and a ...
The exploration of the human connectome, a term denoting the global structural connectivity of the brain, is accessible to MRI at millimeter and centimeter scales. In this paper, we propose a methodology to map the connectome by constructing normalized whole-brain structural connection matrices derived from diffusion spectrum MRI tractography. Using a template-based approach, we propose a robust method that allows a) the selection of identical cortical regions of interest in different subjects with identification of the associated fiber tracts, b) a straightforward construction and interpretation of anatomically organized whole-brain connection matrices, and c) a statistical inter-subject comparison of brain connectivity.. Keywords: LTS5 ; diffusion MRI ; tractography ; connectivity. ...
In this work, we applied a multi-objective evolutionary approach to rewire brain networks and place them within an efficiency-complexity morphospace. Using various Pareto-optimal selection criteria, we were able to explore how brain networks evolve when subject to distinct selection pressures. Furthermore, the approach allowed us to investigate relationships and trade-offs between distinct topological traits associated with the principal axes of the morphospace, Ediff, Erout and CN. Our results demonstrate that the empirical networks we used as seed points for evolution are surrounded by a large space of variant network topologies, even when holding wiring cost constant, including networks that combine a higher capacity to support efficient communication with higher neural complexity.. Our work attempts to make several methodological contributions. First, building on fundamental work in evolutionary theory [44,51,52], we extend the morphospace analysis framework into the realm of human brain ...
Much of the CD4+ T-cell death that occurs during HIV infection may be caused by direct delivery of the virus from neighboring cells, a study shows.. 0 Comments. ...
Manipulate the default connectome provided with TVB to see how structural lesions effect brain dynamics. In this hands-on session you will insert lesions into the connectome within the TVB graphical user interface. Afterwards the modified connectome will be used for simulations and the resulting activity will be analysed using functional connectivity. ...
Manipulate the default connectome provided with TVB to see how structural lesions effect brain dynamics. In this hands-on session you will insert lesions into the connectome within the TVB graphical user interface. Afterwards the modified connectome will be used for simulations and the resulting activity will be analysed using functional connectivity. ...
We have just published a manuscript in PLoS Biology where we describe how to build a complete and accurate neural network. This of course is one of the long standing holy grails in neuroscience. So, this effort meets two goals: 1) It meets the goals of building a complete neural connectome (well be finished collecting all of the data with cell identity, physiologic response and all synaptic connectivity in approximately six days) and 2) It defines a workflow whereby investigators from around the planet can download and use the tools we are providing to build their own connectome projects using existing infrastructure. We are making those tools available here to enable other groups to assemble, browse and annotate the terabyte sized datasets required of connectome level projects.. The breakthroughs in this effort have largely centered on building a framework that can deal with ultrastructural image capture using Transmission Electron Microscopy (TEM) but greatly accelerates the data capture and ...
I would like to propose a metaphor for the relationship between neural activity and connectivity. Neural activity is constantly changing. Its like the water of the stream; it never sits still. The connections of the brains neural network determines the pathways along which neural activity flows. And so the connectome is like bed of the stream; but the metaphor is richer than that, because its true that the stream bed guides the flow of the water, but over long timescales, the water also reshapes the bed of the stream. And as I told you just now, neural activity can change the connectome. And if youll allow me to ascend to metaphorical heights, I will remind you that neural activity is the physical basis - or so neuroscientists think - of thoughts, feelings and perceptions. And so we might even speak of the stream of consciousness. Neural activity is its water, and the connectome is its bed ...
Despite recent advances, the tissue clearing technologies have a fundamental limitation: the working distance of optical microscopy. Without physical sectioning, an objective lens with high numerical aperture (≥1.2) for resolving submicron-resolution details does not have enough working distance (≥0.28 mm) to visualize cellular structures that are more than several millimeters deep. This limitation can be partially addressed by shrinkage-mediated imaging, which reduces the tissue volume after clearing (Pan et al., 2016). However, serial sectioning is still required for 3D imaging and reconstruction of large tissues.. Serial sectioning has been used with transmission EM to reconstruct the whole-body connectome of Caenorhabditis elegans (White et al., 1986; Xu et al., 2013) and larval Drosophila (Ohyama et al., 2015) as well as the partial optic medulla connectome in Drosophila (Takemura et al., 2013). However, the use of transmission EM in connectome reconstruction is limited by the ...
Because of the unique position of the topologically central role of densely interconnected brain hubs, our study aimed to investigate whether these regions and their related connections would be...
Abnormal rich-club metrics are a characteristic feature of PI-related to disease severity. These metrics provide potential clues to PI pathogenesis and may be useful as diagnostic markers and for assessment of treatment response.
For example, one discipline that has been quickly expanding and receiving much attention from the media is connectomics. The aim of this field is to create detailed maps, or connectomes, of all synaptic connections among neurons. This stands in contrast to other more conventional approaches that interrogate specific pathways and networks of connections among a restricted group of neurons. The generation of these connectomes has been strongly pursued through the development of techniques for high-resolution, high-throughput reconstruction of small volumes of nervous tissue. For example, recent work by Kasthuri et al (2015) shows the potential of new electron microscopy (EM) techniques for expanding our understanding of the connections and structure of the brain. Unlike other forms of histology that rely on fluorescence to visualize cells, EM generates high-resolution images that reveal all membranous structures. Kasthuri and colleagues have imaged a square volume of brain slice after brain slice, ...
The DiCIPHR lab focuses on understanding the structural and functional connectivity in the brain when it is healthy, and the ways the connectivity is altered as a result of disease. This is achieved by developing advanced mathematical and computational tools for various aspects of diffusion MRI analysis, as well as multimodal connectomics with applications in the clinic. These tools have enabled investigations in sex differences, healthy brain development, communication scheme brain assumes, autism, brain cancer, and traumatic brain injury. In addition to population-based studies that elucidate imaging patterns of disease, the lab aims to develop subject-specific imaging biomarkers paving the way for precision imaging. Twitter: https://twitter.com/DiCIPHR ...
Markett, S., Montag, C., Heeren, B., Saryiska, R., Lachmann, B., Weber, B., & Reuter, M. (2016). Voxelwise eigenvector centrality mapping of the human functional connectome reveals an influence of the catechol-O-methyltransferase val158met polymorphism on the default mode and somatomotor network. Brain Structure and Function, 221(5), 2755-2765 ...
Mendes, N.; Oligschläger, S.; Lauckner, M.; Golchert, J.; Huntenburg, J. M.; Falkiewicz, M.; Ellamil, M.; Krause , S.; Baczkowski, B.; Cozatl, R. et al.; Osoianu, A.; Kumral, D.; Pool, J.; Golz, L.; Paerisch, M.; Haueis, P.; Jost , R.; Kramarenko, Y.; Engen, H. G.; Ohrnberger, K.; Gorgolewski, K. J.; Farrugia, N.; Babayan, A.; Reiter, A.; Schaare, H. L.; Reinelt, J.; Röbbig, J.; Uhlig, M.; Erbey, M.; Gaebler, M.; Smallwood, J.; Villringer, A.; Margulies, D. S.: A functional connectome phenotyping dataset including cognitive state and personality measures. Scientific Data 6, 180307 (2019 ...
Neurons and their processes, color-coded to distinguish one from another. Credit: Lichtman Lab / Harvard University. The scale of the problem. Since the end of that project, Lichtmans lab has improved further the automation of imaging and analysis, and now, Lichtman says, could reconstruct the same-sized volume of brain tissue (0.0000015 cubic millimeters, or roughly one cell-width across) in a matter of months, not years.. Still, that is only a very tiny volume, on the order of a billionth of a whole mouse brain-or less than a trillionth of a human brain.. The enormity of the connectomics challenge is also apparent when one looks at the data storage requirements. The annotated imagery generated in Lichtmans project required about 3 trillion bytes (terabytes) of storage. According to Kasthuri, mapping a full human brain connectome would require more than 1021 bytes (one zettabyte), which represents a large fraction of the total storage capacity on Earth at present.. Connectomics research ...
Cerebral small vessel disease (SVD) is an important cause of vascular cognitive impairment. Recent studies have demonstrated that structural connectivity of brain networks in SVD is disrupted. However, little is known about the extent and location of the reduced connectivity in SVD. Here they invest …
Nodes were more prone to disease when they were linked by shorter or stronger functional connections. In other words, the transneuronal spread model best fit disease progression.. While Seeleys group started with the data and asked what models best fit, Raj and colleagues came at it from the opposite direction. They built a biophysical model and fit to it MRI data from healthy, AD, and FTD brains. These scientists propose that toxic proteins diffuse through the brain in a classic mechanism whereby concentration gradients drive their random dispersion. This, they posit, follows brain connectivity networks. Their so-called network diffusion model precisely recapitulated the pattern of atrophy progression of AD and behavioral variant frontotemporal dementia. It might even be able to predict what brain regions will atrophy in the future based on baseline MRI morphometrics, Raj and colleagues write.. How can these new models help researchers? Can they aid in diagnosis or prognosis? The authors claim ...
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A new paper in the open access journal PLoS Biology describes a new way to model the human brain using diffusion spectrum imaging. Since were in the omics age of science, you shouldnt be surprised that this map is dubbed the connectome. The semantics of the connectome is similar to genome, proteome, metabalome, transcriptome --…
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Case #1: The Toll-like receptor 3 (TLR3) gene, discovered in the Casanova lab years earlier, causes the life-threatening brain inflammation herpes simplex virus 1 encephalitis (HSE) in children. TLR3 controls innate immunity, impairing a specific interferon.. The human gene connectome produced results both expected and not. We took 2 patients who had HSE and had very recently been discovered to have a disease-causing gene called TBK1, Dr. Itan told me. So we thought if we take gene variations and run them by their distance to TLR3, would TBK1 show up? In both patients, it showed up first, purely based on this computational prediction. The TLR3-specific connectome revealed two novel TLR3 pathway genes prior to their experimental validation - EFGR and SRC.. In a second test case, a mutation in a collagen gene that causes a form of Ehlers-Danlos syndrome pulled out 26 other genes associated with the Ehlers-Danlos syndrome and its genetic pathway.. Finding new genes behind what was thought to be ...
This study examined functional neural predictors of response to EX/RP therapy in unmedicated patients with OCD using a nonaffective cognitive control task. Using up-to-date acquisition and processing methods in line with large-scale studies (e.g., Human Connectome Project [HCP]), group differences in conflict-related responses did not withstand rigorous multiple comparisons correction. However, greater conflict-related activity predicted greater EX/RP response in 36 parcels/regions (of the 374 tested), mainly within cingulo-opercular (e.g., anterior insula, anterior cingulate) and default mode network (DMN; e.g., posterior cingulate, angular gyrus) regions, as well as the DLPFC, pallidum, and areas of visual cortex. Moreover, conflict-related activity on its own predicted which patients achieved remission (operationalized as posttreatment Y-BOCS score ≤ 12) with relatively high sensitivity and specificity. This increased even further to nearly complete separation of which patients achieved ...
TY - JOUR. T1 - Personality and resting state networks in children. T2 - A longitudinal EEG study. AU - Knyazev, Gennady G.. AU - Savostyanov, Alexander N.. AU - Bocharov, Andrey V.. AU - Slobodskaya, Helena R.. AU - Bairova, Nadezhda B.. PY - 2017/11/1. Y1 - 2017/11/1. N2 - The association of personality with resting state networks has been investigated in the mature brain, but its development has not been investigated, particularly in longitudinal design. Besides, all existing evidence is obtained using functional magnetic resonance imaging and there are no data on electrophysiological underpinning of these associations. We have acquired three yearly recordings of resting state EEG data in primary school children. Parental ratings of childs personality were obtained in the third wave. Seed-based oscillatory power envelope correlation analysis in conjunction with beamformer spatial filtering were used to obtain electrophysiological signatures of the default mode network (DMN) associated with ...
The goal of our research is to understand use-driven brain network plasticity in children with brain injury, in order to develop novel neurorehabilitative treatments. To this end, we are studying childrens brains using resting state functional connectivity MRI (rs-fcMRI) and task-based functional MRI (fMRI). We are focused on pushing structural and functional MRI acquisition and analysis methodology to the level of individual patients. In order to create and annotate the connectomes of individuals (Individuomes) we must first improve the signal-to-noise, spatial resolution and replicability of fMRI and rs-fcMRI data. High-fidelity Individuomes should help accelerate fMRI-based diagnostics and neurofeedback rehabilitation therapy.. One of the main complications for rs-fcMRI and fMRI in children is excessive head movement, which introduces systematic distortions. Post-hoc data censoring methods can remove movement artifact from rs-fcMRI data, but in children post-hoc censoring leads to ...
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We have a new publication out (Direct Link, Free Open Access), Retinal Remodeling in Human Retinitis Pigmentosa authored by Bryan W. Jones, Rebecca Pfeiffer, Drew Ferrell, Carl Watt, Michael Marmor and Robert Marc.. Abstract: Retinitis Pigmentosa (RP) in the human is a progressive, currently irreversible neural degenerative disease usually caused by gene defects that disrupt the function or architecture of the photoreceptors. While RP can initially be a disease of photoreceptors, there is increasing evidence that the inner retina becomes progressively disorganized as the outer retina degenerates. These alterations have been extensively described in animal models, but remodeling in humans has not been as well characterized. This study, using computational molecular phenotyping (CMP) seeks to advance our understanding of the retinal remodeling process in humans. We describe cone mediated preservation of overall topology, retinal reprogramming in the earliest stages of the disease in retinal ...
We have a new manuscript out in Clinical Neurophysiology, An Update on Retinal Prostheses. PubMedDirect Link PDF here.. Authors: Lauren N. Ayton, Nick Barnes, Gislin Dagnelie, Takashi Fujikado, Georges Goetz, Ralf Hornig, Bryan W. Jones, Mahiul M.K. Muqit, Daniel L. Rathbun, Katarina Stingl, James D. Weiland, Matthew A. Petoe.. Abstract: Retinal prostheses are designed to restore a basic sense of sight to people with profound vision loss. They require a relatively intact posterior visual pathway (optic nerve, lateral geniculate nucleus and visual cor- tex). Retinal implants are options for people with severe stages of retinal degenerative disease such as retinitis pigmentosa and age-related macular degeneration.. There have now been three regulatory-approved retinal prostheses. Over five hundred patients have been implanted globally over the past 15 years. Devices generally provide an improved ability to localize high-contrast objects, navigate, and perform basic orientation tasks. Adverse ...
Methodology to annotate the multiple origins of axonal projections in dense electron microscopy data of mammalian nervous tissue without the need of chemical label conversion is reported.
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This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by J Scott Lauritzen, Noah T. Nelson, Crystal L. Sigulinsky, Nathan Sherbotie, John Hoang, Rebecca L. Pfeiffer, James R. Anderson, Carl B. Watt, myself and Robert E. Marc.. Purpose: Despite large-scale efforts aimed at mapping the mammalian nervous system, the entire synaptic cohort of a single mammalian neuron of any class has never been mapped. To this end we reconstructed all chemical and electrical synaptic partners of a single ON cone bipolar cell in the inner plexiform layer (IPL) of the rabbit retina. We then searched all members of the same cell class for repeating network motifs and explored postsynaptic cell sampling topologies from this bipolar cell.. Methods: Cells in retinal connectome 1 (RC1) were annotated with Viking viewer, and explored via graph visualization of connectivity and 3D rendering (Anderson et al., 2011 J Microscopy). Small molecule ...
BRAIN SCIENTISTS the world over have tinkered with capturing a complete model of the human brain for the purposes of achieve a full understanding its how it functions. The amount of information required about the human brain operations has exploded. From image captures focused on individual neurons to whole scale network tracings of the brain connectome, and from the creative and destructive roles of glial cells, numerous efforts are underway to achieve computational representation of the brains 10^11 neurons, each with 10^4 synapses, and the action potentials 100 billion neurons.. A lingering related question is what would happen if a fully specified computational model - a simulation - of the human brain was built? More precisely, what would happen if it were turned on? Would it, or more precisely could it, perceive consciousness? Could it be taught? What would it think about? What would it think about itself? What would think about us?. There has been success in building simulations of ...
Biologically-reliable computer simulation of the nervous system is the cross-disciplinary area of research which is quite novel and mostly related to neurobiology, neurocybernetics and artificial intelligence. The main idea is to study the mechanisms of brain functioning by means of investigation of its work in details at neuronal and subneuronal level (membranes, neurites, neuromediators, ion channels etc.) and implementation of this data and knowledge within a dynamic model. Its quite obvious to start from the most simple organism to test the overall conception, and continue with more complex ones in case of success. For this purpose C. elegans nematode is currently the only animal with almost known neural network architecture (connectome). Moreover, its structure, including neurons positions, morphological features and interneuron connections is invariant for all animals of one sex. Relative simplicity but still quite complex behavioral patterns, as well as abilities for learning and memory ...
Large-scale neural model of visual short term memory embedded into a 998-node connectome. The model simulates electrical activity across neuronal populations of a number of brain regions and converts that activity into fMRI and MEG time-series. The model uses a neural simulator developed at the Brain Imaging and Modeling Section of the National Institutes of Health ...
Large-scale neural model of visual short term memory embedded into a 998-node connectome. The model simulates electrical activity across neuronal populations of a number of brain regions and converts that activity into fMRI and MEG time-series. The model uses a neural simulator developed at the Brain Imaging and Modeling Section of the National Institutes of Health ...
Whitaker, K. J.; Vértes, P. E.; Romero-Garcia, R.; Vása, F.; Moutoussis, M.; Prahub, G.; Weiskopf, N.; Callaghan, M. F.; Wagstyl, K.; Rittmann, T. et al.; Tait, R.; Ooi, C.; Suckling, J.; Inkster, B.; Fonagy, P.; Dolan, R. J.; Jones, P. B.; Goodyer, I. M.; the NSPN Consortium; Bullmore, E. T.: Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome. Proceedings of the National Academy of Sciences of the United States of America 113 (32), pp. 9105 - 9110 (2016 ...
Mechling AE, Arefin T, Lee H-L, Bienert T, Reisert M, Ben Hamida S, Darcq E, Ehrlich A, Gaveriaux-Ruff C, Parent MJ et al.. 2016. Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome.. Proc Natl Acad Sci U S A. 113(41):11603-11608. ...
Mechling AE, Arefin T, Lee H-L, Bienert T, Reisert M, Ben Hamida S, Darcq E, Ehrlich A, Gaveriaux-Ruff C, Parent MJ et al.. 2016. Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome.. Proc Natl Acad Sci U S A. 113(41):11603-11608. ...
Todays Water Cooler: Impeachment v. trade bill, France v. US, US v. China, Biden, Buttigieg, Sanders, Warren, Jewish-Americans, Stacey Abrams, employment, manufacturing, services, shipping, potatoes, another IoT debacle, P4HCAF, prison staffing, slavery, the connectome, the Dead
杭州师范大学静息态功能磁共振影像免费培训(第四期). 2019年04月14日(周日) 13:00-17:00. 主办单位:. 杭州师范大学心理科学研究院. 杭州师范大学附属医院认知与脑疾病研究中心. 浙江省认知障碍评估技术研究重点实验室. 承办单位:. 杭州拾睿科技有限公司. 为了加强社会服务,杭州师范大学拟针对静息态功能磁共振影像研究者开展免费培训服务,暂定每月一次。. 第四期讲座的题目为Resting-state fMRI and state fMRI Design: data analysis and application,时间定于2019年04月14日13:00-17:00。本次讲座主要面向心理学领域从事静息态功能磁共振影像或拟采用state任务fMRI设计的研究者,通过QQ网络的方式进行。感兴趣的朋友请填写附件中的报名表格,并发送邮件至贾熙泽([email protected])。. 讲者及简介:. 1. 题目:Resting-state fMRI and state fMRI ...
Connectomics and Cortical Transistors Margie shares; German scientists have recently discovered a precise nerve cell connectivity pattern (nerve cell circuits) in part of the cerebral cortex, which is responsible for orienting us in space. These grid cells provide a very particular representation of the space around the individual human and are known to be active when we are located at highly ordered grid-like locations in a room or a large space.. Read more within the following articles and research;. ...
This work was supported by National Institutes of Health DC 016293 and USAFOSR FA9550-17-1-0117 to A.M.D.; Howard Hughes Medical Institute Janelia Research Campus Visiting Scientist Program project to A.M.D. and K.E.C.; and Wellcome Trust Collaborative Award 203261/Z/16/Z and National Institutes of Health RF1 MH120679 01 Award to D.D.B. The Howard Hughes Medical Institute supported the generation and hosting of the FAFB dataset. We thank the FAFB tracing community for helpful insights and contributions of neuron tracings; Tom Kazimiers and Andrew Champion for CATMAID development; Peter Li for development of the autosegmented instance of the FAFB dataset; Eric Perlman for making the autosegmented dataset available in CATMAID; the Cambridge Drosophila Connectomics group, especially Greg Jefferis, Marta Costa, Philipp Schlegel, Alex Bates, Ruairi Roberts, Robert Turnbull, Lisa Marin, and Nik Drummond for use of hundreds of neuron reconstructions, assistance with custom analyses, and facilitating ...
Alison Calder, raised and partly educated in Saskatoon, is now a professor of literature at the University of Manitoba and a poet and critic with numerous publications to her credit. In the fascinating Connectomics she writes of neural pathways, where various emotions and memories are stored in the brain, and how we go about mapping that still mysterious organ in our skulls.. Whats most fascinating about this small collection is not the science itself, which has its appeal, but the way in which Calder toys with the idea of how to describe a place so important to us but to which so very few of us go, or even care to know. The brain, to most people, is just the brain until something goes wrong with it, but right now thousands of scientists are mapping it and trying to understand its functions. In Infinity Calder opens, After we exhausted wonder/ we shut down the computers, turned off/ the lights. Everything/ was known, and ends, We grew our knowledge right up to the end./ When we got to the ...
Focused Ion Beam Scanning Electron Microscopy (FIB-SEM) can automatically generate 3D images with superior z-axis resolution, yielding data that needs minimal image registration and related post-processing. Obstacles blocking wider adoption of FIB-SEM include slow imaging speed and lack of long-term system stability, which caps the maximum possible acquisition volume. Here we present techniques that accelerate image acquisition while greatly improving FIB-SEM reliability, allowing the system to operate for months and generating continuously imaged volumes , 10(6) µm(3). These volumes are large enough for connectomics, where the excellent z resolution can help in tracing of small neuronal processes and accelerate the tedious and time-consuming human proofreading effort. Even higher resolution can be achieved on smaller volumes. We present example data sets from mammalian neural tissue, Drosophila brain, and Chlamydomonas reinhardtii to illustrate the power of this novel high-resolution technique ...
Researchers have developed reconstruction software that allows them to gain an about 10-fold speedup for data analysis in connectomics.
Genomics was driven by increasing technology and was addictive, because, it is not too cynical to say, it was thought-free, meat-grinder, factory science. It was lucrative, did indeed teach us a lot about what genes and genomes do, and found a modest number of important causal genes. Its success, at least in the fashion and funding senses, understandably spawned other hypothesis-free blind technological approaches, cashing in on the cachet of the omics word and its rejection of the need for actual prior hypotheses to design studies: nutriomics, connectomics, metabolomics, microbiomics, immunomics, epigenomics, and more. How much of this was because the same people who were promising us that successful disease prediction with genetics was right around the corner realized that this just wasnt true, and needed to figure out ways to keep their labs running we cant say, but we certainly are a fad-following, money-following research culture and we know this is part of the story. To be fair, when ...
Interest in brain connectivity inference has become ubiquitous and is now increasingly adopted in experimental investigations of clinical, behavioral, and experimental neurosciences. Methods in Brain
How does the brain integrate multiple sources of information to support normal sensorimotor and cognitive functions? To investigate this question we present an overall brain architecture (called
Provides the latest translational research discoveries in brain mapping, modeling, novel research techniques, and more in the rapidly advancing field of connectivity research at the systems and network levels.
Principal Investigator:Matsumoto Riki, Project Period (FY):2014-04-01 - 2016-03-31, Research Category:Grant-in-Aid for Challenging Exploratory Research, Research Field:Brain biometrics
An anonymous reader writes Researchers in the Midwest are developing microelectronic circuitry to guide the growth of axons in a brain damaged by trauma. The goal is to rewire the brain connectivity and bypass the damaged region in order to restore normal behavior and movement. The device, which [...
At a press event in New York today, IFC announced that it has renewed freshman news show Onion News Network for a second season. Additionally, IFC has greenlit four new original docu series: Commercial Kings from Reveille; Young, Broke & Beautiful, produced by 44 Pictures; Whisker Wars, produced...
Bodyguards Keely Hawes, Veeps Sally Phillips and Three Girls Jill Halfpenny have joined IFC and C4s comedy series Year of the Rabbit.
To watch full episodes, you must have a cable provider that supports IFCs full episode service and you must have IFC as part of your cable package.. ...
Connectome[edit]. Drosophila is one of the few animals (C. elegans being another) where detailed neural circuits (a connectome ... Detailed circuit-level connectomes exist for the lamina[83][84] and a medulla[85] column, both in the visual system of the ... In 2020, a dense connectome of half the central brain of Drosophila was released,[89] along with a web site that allows queries ... A high-level connectome, at the level of brain compartments and interconnecting tracts of neurons, exists for the full fly ...
More recently, he has pioneered a new approach to connectome mapping using the methods of molecular biology, which may ... CS1 maint: discouraged parameter (link) "Sequencing the Connectome: Will DNA Bar Codes and a Sneaky Virus Change the Way ... "Sequencing the Connectome". PLOS Biology. 10 (10): e1001411. doi:10.1371/journal.pbio.1001411. PMC 3479097. PMID 23109909. ...
Dick, Anthony Steven; Bernal, Byron; Tremblay, Pascale (15 December 2013). "The Language Connectome". The Neuroscientist. 20 (5 ...
An Interactive Connectome". Frontiers in Neuroinformatics. 5: 7. doi:10.3389/fninf.2011.00007. ISSN 1662-5196. PMC 3147162. ...
Connectome Connectomics Human Connectome Project Brain mapping Tractography Chord diagram Irimia, Andrei; Chambers, M.C.; ... "Human Connectome Project". NIH. "Hard Cell". The Economist. 9 March 2013. Retrieved 11 March 2013. CS1 maint: discouraged ... Most other representations of the connectome use 3 dimensions, and therefore require an interactive graphical user interface. ... "Imaging human connectomes at the macroscale". Nature Methods. 10 (6): 524-39. doi:10.1038/nmeth.2482. PMC 4096321. PMID ...
Leergaard, Trygve (2011). Mapping the Connectome. Frontiers. p. 135. ISBN 978-2889191079. "Center for Peacemaking Practice". ...
... "functional connectome", as well as new technologies that will have to be developed in the course of the project. They indicated ... "Sequencing the Connectome". PLOS Biology. 10 (10): e1001411. doi:10.1371/journal.pbio.1001411. PMC 3479097. PMID 23109909. "NIH ... Therapeutic Scientific Summit Human Connectome Project List of animals by number of neurons List of neuroscience databases ...
Kucyi, A, Davis KD (2015). "The dynamic pain connectome.". Trends Neurosci. 38 (2): 86-95. Kucyi, A., Salomons, T. V., Davis, K ... The other concept is called the Dynamic Pain Connectome which emphasizes that spatiotemporal representation of pain in the ... S2CID 43326133.CS1 maint: uses authors parameter (link) Kucyi, A, Davis KD (February 2015). "The dynamic pain connectome.]". ... From Single-Cell Electrophysiology to the Dynamic Pain Connectome.]". Neuroscientist. 23 (4): 397-414. doi:10.1177/ ...
"Muse Launch Social Connectome , Altsounds.com News". Hangout.altsounds.com. 21 September 2012. Archived from the original on 23 ... The album's cover art, taken from the Human Connectome Project, represents the map of the human brain's pathways, "tracking the ... The artwork was subsequently used by Muse in a social Connectome Project on 21 September 2012. As more fans joined the online ... which was taken from the Human Connectome Project. Recording of the album took place in four different studios, began in ...
As well as work directly within her research group, she is a collaborator on the developing Human Connectome Project (dHCP), a ... "Teams and Collaborators , The Developing Human Connectome Project". www.developingconnectome.org. "Scientific Committee". www. ...
Picchioni, Dante; Duyn, Jeff H.; Horovitz, Silvina G. (2013-10-15). "Sleep and the functional connectome". NeuroImage. 80: 387- ... "The structural-functional connectome and the default mode network of the human brain". NeuroImage. 102: 142-151. doi:10.1016/j. ...
Bibliome Connectome Cytome Editome Embryome Epigenome Methylome Exposome Envirome Toxome Foodome Microbiome Sociome Genome ... Kopell, Nancy J.; Gritton, Howard J.; Whittington, Miles A.; Kramer, Mark A. (2014-09-17). "Beyond the connectome: the dynome ... DeFelipe, Javier (2010-11-26). "From the Connectome to the Synaptome: An Epic Love Story". Science. 330 (6008): 1198-1201. ... Moleculome Glycome Ionome Lipidome Metabolome Volatilome Metallome Proteome Obesidome Organome Phenome Physiome Connectome ...
Functional Connectome of the Fetal Brain. J Neurosci. 2019 Dec 4;39(49):9716-9724. doi: 10.1523/JNEUROSCI.2891-18.2019. Epub ...
It is then possible to trace each motor axon and its synaptic contacts to construct a complete connectome of the muscle. More ... Lichtman, Jeff; Jean Livet; Joshua Sanes (June 2008). "A technicolour approach to the connectome". Nature Reviews Neuroscience ...
Lichtman JW, Livet J, Sanes JR (2008). "A technicolour approach to the connectome". Nat Rev Neurosci. 9 (6): 417-22. doi: ... Sample I (7 May 2012). "Quest for the connectome: scientists investigate ways of mapping the brain". The Guardian. Retrieved 9 ... to construct a full connectome of the mouse retina. The lab is also interested in inhibitory interneurons in the prefrontal ...
"Parameterizable consensus connectomes from the Human Connectome Project: the Budapest Reference Connectome Server v3.0". ... "How to Direct the Edges of the Connectomes: Dynamics of the Consensus Connectomes and the Development of the Connections in the ... The connectome can be constructed from diffusion MRI data: the vertices of the graph correspond to anatomically labelled gray ... The Consensus Connectome Dynamics (CCD) is a remarkable phenomenon that was discovered by continuously decreasing the minimum ...
"Multimodal mapping of the face connectome". Nature Human Behavior. 4: 397-411. Jankowiak, J., Albert, M.L., 1994. Lesion ...
... forms a parallel wireless connectome whose topological features and modes of interaction with the wired connectome could be ... "The Multilayer Connectome of Caenorhabditis elegans". PLOS Computational Biology. 12 (12): e1005283. arXiv:1608.08793. Bibcode: ... elegans neural connectome. In particular, he recognised that neuromodulatory signaling, being largely extrasynaptic, ... "Network control principles predict neuron function in the Caenorhabditis elegans connectome". Nature. 550 (7677): 519-523. ...
April 2014). "A mesoscale connectome of the mouse brain". Nature. 508 (7495): 207-14. Bibcode:2014Natur.508..207O. doi:10.1038/ ...
At higher resolutions brain maps are called connectomes. These maps incorporate individual neural connections in the brain and ... Shi, Y (May 2017). "Connectome imaging for mapping human brain pathways". Nature. 22 (9): 1230-1240. doi:10.1038/mp.2017.92. ... brain Brain Mapping Foundation BrainMaps Project Center for Computational Biology Connectogram FreeSurfer Human Connectome ...
Connectome Neuroanatomy Stereotaxic atlas Stereotaxy Beliveau, Vincent; Ganz, Melanie; Feng, Ling; Ozenne, Brice; Højgaard, ...
"Parameterizable consensus connectomes from the Human Connectome Project: the Budapest Reference Connectome Server v3.0". ... The connectome, or the braingraph, can be constructed from diffusion MRI data: the vertices of the graph correspond to ... The Budapest Reference Connectome Server depicts the cerebral connections of n=418 subjects with a frequency-parameter k: For ... The Consensus Connectome Dynamics (CCD) is a remarkable phenomenon that was discovered by continuously decreasing the minimum ...
... and other uses in biology connectome, proteome; biome, rhizome, vacuome -on < electron an elementary particle or quasiparticle ...
Andrews AM (May 2013). "The BRAIN Initiative: toward a chemical connectome". ACS Chemical Neuroscience. 4 (5): 645. doi:10.1021 ...
Melodic for ICA), CONN, C-PAC, and Connectome Computation System (CCS). There are many methods of both acquiring and processing ... "Resting-state fMRI in the Human Connectome Project". NeuroImage. 80: 144-168. doi:10.1016/j.neuroimage.2013.05.039. ISSN 1053- ... "Consistency of network modules in resting-state FMRI connectome data". PLOS ONE. 7 (8): e44428. Bibcode:2012PLoSO...744428M. ...
The connectome scanner generates a map of the axons in white matter, connections of the brain, by measuring the nearby movement ... CS1 maint: discouraged parameter (link) Scott, Tom; Jones, Derek (24 July 2017). Connectome Scanning: Looking at the Brain's ... Official website Tour of CUBRIC Building Simple Explanation of Connectome Scanning Delivery of 7T MRI Scanner. ... laboratories 10 cognitive method laboratories the first connectome scanner outside the United States, a Siemens 3 Tesla ...
This data release introduced the first on-line tools to query the connectome. Connectomes of higher organism's brains requires ... The connectome of C. elegans was the seminal work in this field. This circuit was obtained with great effort using manually cut ... A specific example of this technology is the NeuPrint interface to the connectomes generate at HHMI. This mimics the ... PMID 20833533.CS1 maint: multiple names: authors list (link) Jason Pipkin (Oct 8, 2020). "Connectomes: Mapping the mind of a ...
Marc RE, Anderson JR, Jones BW, Sigulinsky CL, Lauritzen JS (4 September 2014). "The AII amacrine cell connectome: a dense ...
Pavlou HJ, Goodwin SF (February 2013). "Courtship behavior in Drosophila melanogaster: towards a 'courtship connectome'". ...
The use of functional connectomes to predict individual differences is known as "functional connectome fingerprinting" and ... For example, a recent line of research has demonstrated that individual differences in functional connectomes, which are ... Functional connectomes can be distilled into constituent intrinsic brain networks that are present during sleep, at rest, and ... "Functional Connectome of the Five-Factor Model of Personality". Personality Neuroscience. 1: e2. doi:10.1017/pen.2017.2. ISSN ...
AS Seeds Featured Blogger of the week, I have written a short article about the Human Connectome Project, in response to a ... Part of the problem is that there is no such thing as "the connectome". The STG that Bjorn mentions is a perfect example. ... Also, I wonder what you make of these publications on connectomes:. * Hagmann P, Kurant M, Gigandet X, Thiran P, Wedeen VJ, ... Part of the problem is that there is no such thing as "the connectome". The STG that Bjorn mentions is a perfect example. ...
The connectome can be studied as a network by means of network science and graph theory. In case of a micro-scale connectome, ... The term "connectome" was more recently popularized by Sebastian Seungs I am my Connectome speech given at the 2010 TED ... The Budapest Reference Connectome has led the researchers to the discovery of the Consensus Connectome Dynamics of the human ... Brain connectivity estimators Drosophila connectome Human Connectome Project Interactome List of animals by number of neurons ...
Building on methodological advances from the Human Connectome Project (HCP) and elsewhere, the HCP-style paradigm applies to ... particularly from the Human Connectome Project (HCP). The HCP-style paradigm has seven core tenets: (i) collect multimodal ... The Human Connectome Projects neuroimaging approach. *Matthew F Glasser. 1. , *Stephen M Smith ORCID: orcid.org/0000-0001-8166 ... Glasser, M., Smith, S., Marcus, D. et al. The Human Connectome Projects neuroimaging approach. Nat Neurosci 19, 1175-1187 ( ...
A natural question is whether the connectome will allow simulation of the flys behavior. However, the connectome alone is not ... Detailed circuit-level connectomes exist for the lamina and a medulla column, both in the visual system of the fruit fly, and ... The Drosophila connectome, once completed, will be a complete list of the roughly 135,000 neurons in the brain of the fruit fly ... A full connectome of a large portion of the central brain is likewise available. Many of the 76 compartments of the Drosophila ...
The U.S. governments Human Connectome Project moves into its second phase-and its brain scans are being used to predict ... Advances in medical imaging allow the Human Connectome Project to map neural connections ...
Lichtman, J., Livet, J. & Sanes, J. A technicolour approach to the connectome. Nat Rev Neurosci 9, 417-422 (2008). https://doi. ...
The Baby Connectome Project (BCP) is a four-year study of children from birth through five years of age, intended to provide a ... The BCP is one of several programs that build upon the NIHs Human Connectome Project (HCP), an ambitious effort to map the ... Coordinate with other components of the Human Connectome Project.. Results & Accomplishments. Media. UNC Press Release ( ... Wyeth Nutrition Press Release (July 6, 2016):National Institutes of Healths Baby Connectome Project Advances with Support from ...
Sex differences in structural connectome. Madhura Ingalhalikar, Alex Smith, Drew Parker, Theodore D. Satterthwaite, Mark A. ... Sex differences in structural connectome. Madhura Ingalhalikar, Alex Smith, Drew Parker, Theodore D. Satterthwaite, Mark A. ... Sex differences in the structural connectome of the human brain. Madhura Ingalhalikar, Alex Smith, Drew Parker, Theodore D. ... In this work, we modeled the structural connectome using diffusion tensor imaging in a sample of 949 youths (aged 8-22 y, 428 ...
Sporns, O., Tononi, G., & Kötter, R. (2005). The human connectome: A structural description of the human brain. PLoS ...
NIH Human Connectome Project RFA * Home page of the Human Connectome Project consortium centered at Washington University and ... The connectome at the large scale. There are several established empirical approaches that allow the construction of connectome ... The future of the connectome. While the full connectome at cellular resolution seems presently out of reach, at least for the ... The connectome is the complete description of the structural connectivity (the physical wiring) of an organisms nervous system ...
Mapping The Structural Connectome in Autism. March 1st, 2013 John Hewitt Neurology, News, Radiology ... Study in NeuroImage: The structural connectome of the human brain in agenesis of the corpus callosum ...
Mathematics of the Human Brain Connectome Mathematics of the Human Brain Connectome ... The human brain connectome is an ambitious project to provide a complete map of neural connectivity and a recent source of ... the human connectome is a result of a similar union. The technology in question is that of diffusion magnetic resonance imaging ...
I will present recent works that show (1) how manifolds learning techniques applied to whole-brain diffusion MRI connectomes ... Here, I present novel approaches to model structural connectome data based on cutting edge manifold learning techniques that ... how they can index connectome-level perturbations in autism spectrum conditions, a prevalent and persistent condition of brain ... Structural connectome manifolds in typical and atypical development Recording of Presentation. Video of Feindel Virtual Brain ...
The brains connectome - from branch to branch. Max Planck scientists develop new analytical tools for the fast and accurate ... the connectome - and to reconstruct it in a three-dimensional map. Since no computer is powerful enough yet for the task, ...
We call this neuronal ensemble the "gut connectome" and summarize the work from a food sensory perspective. ...
The C. elegans connectome should be discussed more completely, as it is the only connectome that has been found so far. ... The "connectome" article should be rewritten to truly focus on connections. Right now the only method for finding connectomes ... Id like to call for a more careful definition of the term "connectome." For this we need a more precise definition of ... Heres another way to think about it: The connectome follows the tradition of Brenner...though he hates the word :) The ...
Q: Do you foresee the efforts to map the human connectome shedding light any time soon on the tendency of Alzheimers, ... "Network Epicenters" in Healthy Connectome Predict Dementia. Tuesday, April 10, 2012 at 12:00 AM US EDT. ... Could scientists even foretell where and when pathology will surface just by looking at the connectome of a healthy person? ...
C. elegans connectome. The filled nodes are the previously-known neurons involved in the worms response to gentle touch. ... Network control principles predict neuron function in the Caenorhabditis elegans connectome.. Yan G1,2, Vértes PE3, Towlson EK1 ... c) The C. elegans connectome used in our study, consisting of 279 neurons (the 282 nonpharyngeal neurons, excluding CANL/R and ... Here we fill this gap by applying a control framework to the connectome of the nematode Caenorhabditis elegans, allowing us to ...
Furthermore, the functional connectome is thought to be more flexible, while the anatomical connectome is relatively stable [25 ... The anatomical connectome exhibited typical features of small-word topology no matter pre- or post-ECT. However, no significant ... Reorganization of Anatomical Connectome following Electroconvulsive Therapy in Major Depressive Disorder. Jinkun Zeng. ,1 ... O. Sporns, G. Tononi, and R. Kötter, "The human connectome: a structural description of the human brain," PLoS Computational ...
A probabilistic atlas of human brainstem pathways based on connectome imaging data.. Tang Y1, Sun W2, Toga AW2, Ringman JM3, ... With the release of high-resolution data from the Human Connectome Project (HCP), there is increasing interest in mapping human ... Finally, we leveraged our novel connectome modeling techniques including high order fiber orientation distribution (FOD) ...
Connectome-Specific Harmonic Waves. Artificial Neural Networks. Neuroscience. CSHW. Meditation. Enlightenment. Cybernetics. ... E]igendecomposition of the Laplace operator means finding the harmonics of the connectome. Unstated in this sentence is the ... Selen Atasoy and her lab have confirmed resonance of brainwaves bouncing through the connectome. The neurons in a single ... In 2016, Selen Atasoy published a paper in Nature Communications titled Human brain networks function in connectome-specific ...
The Human Connectome Project intends to map the neural pathways that underlie human brain function. This week NIH has awarded ... Human Connectome Project Starts Mapping the Human Brains Connections. September 20th, 2010 Wouter Stomp Neurology, News ... The Human Connectome Project intends to map the neural pathways that underlie human brain function. This week NIH has awarded ... Processed data from the project will become web accessible via a customized Connectome Database Neuroinformatics Platform.. ...
Human Connectome Project, Jeff Lichtman, mapping the brain, Mapping the Connectome, memory, molecular biology, neurobiology, ... Human Connectome Project, Jeff Lichtman, mapping the brain, Mapping the Connectome, memory, molecular biology, neurobiology, ... Human Connectome Project, Jeff Lichtman, mapping the brain, Mapping the Connectome, memory, molecular biology, neurobiology, ... Jeff, whats the Connectome? JEFF LICHTMAN, BIOLOGIST: Well, on this stage you have four people who would probably have a ...
But one of the most ambitious programs in all of neuroscience, the Human Connectome Project, has just yielded a ... But one of the most ambitious programs in all of neuroscience, the Human Connectome Project, has just yielded a "network map" ... Join leading neuroscientists and psychologists as they explore how the connectome promises to revolutionize treatments for ...
Filed Under: Technology & Innovation Tagged With: brain, Connectome, neural, neural pathways, Neurons ... Brain Researchers Start Mapping the Human Connectome. July 2, 2012. by SharpBrains ...
Connectome-wide, genome-wide scan discovers SPON1. Neda Jahanshad, Priya Rajagopalan, Xue Hua, Derrek P. Hibar, Talia M. Nir, ... Connectome-wide, genome-wide scan discovers SPON1. Neda Jahanshad, Priya Rajagopalan, Xue Hua, Derrek P. Hibar, Talia M. Nir, ... Connectome-wide, genome-wide screening offers substantial promise to discover genes affecting brain connectivity and risk for ... Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Neda Jahanshad, Priya ...
... Nat Hum Behav. 2020 Apr;4(4):397-411. doi: 10.1038/s41562-019-0811-3. Epub 2020 Jan ... anatomical and functional connectivity measurements with behavioural assays to create a global model of the face connectome. We ...
... Neuroimage. 2017 Dec;163:41-54. doi: 10.1016/ ... We used two independent cohorts of participants from the Human Connectome Project, each of which had data from four imaging ...
The mammalian AII retinal amacrine cell is a narrow-field, multistratified glycinergic neuron best known for its role in collecting scotopic signals from rod bipolar cells and distributing them to ON and OFF cone pathways in a crossover network via a
Creator & director : email [email protected] Cryonics-for-Connectomes or Connectome-Cryonics are equivalent terms for ... in uploading by definition but rather reversible suspended animation which does require proof of survival of connectomes ...
  • This effort is pursued by the Human Connectome Project, sponsored by the National Institutes of Health (NIH), whose focus is to build a network map of the human brain in healthy, living adults. (wikipedia.org)
  • AS Seed's Featured Blogger of the week, I have written a short article about the Human Connectome Project , in response to a news story on the magazine's website, called Mapping the brain's highways , by Azeen Ghorayshi. (scienceblogs.com)
  • Several weeks ago, the National Institutes of Health announced the Human Connectome Project, an ambitious $30 million five-year initiative, which aims to map the connectivity of the human brain. (scienceblogs.com)
  • Any comments, about either of the articles or about the connectome project itself, should be posted here. (scienceblogs.com)
  • This paper presents an integrated approach to data acquisition, analysis and sharing that builds upon recent advances, particularly from the Human Connectome Project (HCP). (nature.com)
  • The WU-Minn Human Connectome Project: an overview. (nature.com)
  • Pushing spatial and temporal resolution for functional and diffusion MRI in the Human Connectome Project. (nature.com)
  • The minimal preprocessing pipelines for the Human Connectome Project. (nature.com)
  • The Baby Connectome Project (BCP) is a four-year study of children from birth through five years of age, intended to provide a better understanding of how the brain develops from infancy through early childhood and the factors that contribute to healthy brain development. (fnih.org)
  • The BCP is one of several programs that build upon the NIH's Human Connectome Project (HCP), an ambitious effort to map the neural pathways that underlie human brain function. (fnih.org)
  • Coordinate with other components of the Human Connectome Project. (fnih.org)
  • The human brain connectome is an ambitious project to provide a complete map of neural connectivity and a recent source of excitement in the neuroscience community. (princeton.edu)
  • The Human Connectome Project intends to map the neural pathways that underlie human brain function. (medgadget.com)
  • Processed data from the project will become web accessible via a customized Connectome Database Neuroinformatics Platform. (medgadget.com)
  • But one of the most ambitious programs in all of neuroscience, the Human Connectome Project, has just yielded a "network map" that is shedding light on the intricate connectivity in the brain. (worldsciencefestival.com)
  • Identifying every one of these cortical areas became a major objective of the Human Connectome Project, the HCP, needing the effort of a master mapmaker. (worldsciencefestival.com)
  • We used two independent cohorts of participants from the Human Connectome Project, each of which had data from four imaging modalities. (nih.gov)
  • This Funding Opportunity Announcement (FOA) invites applications to build on the data collected using the very well defined experimental protocols of the Human Connectome Project (HCP) ( http://www.neuroscienceblueprint.nih.gov/connectome/ ). (nih.gov)
  • Prior to the Human Connectome Project (HCP), little neural connectivity data from humans was available. (nih.gov)
  • The Human Connectome Project (HCP) has tackled one of the great scientific challenges of the 21st century: mapping the human brain, aiming to connect its structure to function and behavior. (humanconnectome.org)
  • In this study, we investigated these three directions using publicly available resting-state functional magnetic resonance imaging data from the Human Connectome Project. (springer.com)
  • Smith, S.M.: Resting-state fMRI in the human connectome project. (springer.com)
  • The Human Connectome Project and Connectome Coordination Facility are funded by the National Institutes of Health, and all information in this site is available to the public domain. (humanconnectome.org)
  • The member universities of the Human Connectome Project take privacy very seriously, whether dealing with participant data or the data of those visiting this website. (humanconnectome.org)
  • We tested this hypothesis by investigating effective connectivity in a large-scale fMRI dataset from the Human Connectome Project. (harvard.edu)
  • We applied advanced diffusion MRI fiber tractography to a population-based atlas constructed with data from a total of 488 subjects from the Human Connectome Project-488. (ovid.com)
  • The purpose of this Notice is to clarify issues regarding the collection of genotype data and the use of professional project management for RFA-MH-10-020 "The Human Connectome Project," which was issued on July 15, 2009. (nih.gov)
  • Professional project management is paramount to the performance of the Human Connectome Project. (nih.gov)
  • The International Neuroimaging Data-Sharing Initiative (INDI) announces the public release of the 'Attention Deficit Hyperactivity Disorder (ADHD)-200 Sample' via the 1000 Functional Connectomes Project. (nitrc.org)
  • In accordance with HIPAA guidelines and 1000 Functional Connectomes Project protocols, all datasets are fully anonymous, with no protected health information included. (nitrc.org)
  • The Developing Human Connectome Project is funded through a Synergy Grant by the European Research Council (ERC) under the European Union's Seventh Framework Programme (FP/2007-2013) / ERC Grant Agreement n. 319456. (developingconnectome.org)
  • The Developing Human Connectome Project (dHCP) is a study to map the growth of the baby's brain during pregnancy and how it continues to develop after birth. (developingconnectome.org)
  • The science behind the project: what is a connectome? (developingconnectome.org)
  • We unified the connectomes of 96 people (computed from MRI datasets of the Human Connectome Project) into a reference brain graph, which can be downloaded and visualized using this site. (pitgroup.org)
  • Balázs Szalkai, Csaba Kerepesi, Bálint Varga, Vince Grolmusz, Parameterizable Consensus Connectomes from the Human Connectome Project: The Budapest Reference Connectome Server v3.0, , Cognitive Neurodynamics , (2016), http://dx.doi.org/10.1007/s11571-016-9407-z . (pitgroup.org)
  • The Baby Connectome Project (BCP) will investigate the physical changes taking place in a baby or child's brain. (studypages.com)
  • The developing Human Connectome Project (dHCP) aims to create a detailed 4-dimensional connectome of early life spanning 20-45 weeks post-menstrual age. (kcl.ac.uk)
  • Heritability of fractional anisotropy in human white matter: a comparison of Human Connectome Project and ENIGMA-DTI data. (ox.ac.uk)
  • The NIH-funded Human Connectome Project (HCP) is providing data valuable for analyzing the degree of genetic influence underlying brain connectivity revealed by state-of-the-art neuroimaging methods. (ox.ac.uk)
  • A new project, dubbed " The Human Connectome ," will take few years and cost $30 Million, will map out approximately 100 billion neurons and 150 trillion synapses. (wordpress.com)
  • Select the "Rat Neurome Project" page under the "Connectome" link on the menu at the top. (larrywswanson.com)
  • In this communication, we combined data from the detailed mappings of early twentieth century cytoarchitectonic pioneers Von Economo and Koskinas (1925) on the microscale cellular structure of the human cortex with data on macroscale connectome wiring as derived from high-resolution diffusion imaging data from the Human Connectome Project. (harvard.edu)
  • The MGH-USC CONNECTOM MRI scanner housed at the Massachusetts General Hospital (MGH) is a major hardware innovation of the Human Connectome Project (HCP). (harvard.edu)
  • QandA: What is the Open Connectome Project - Descarga este documento en PDF. (duhnnae.com)
  • The production and study of connectomes, known as connectomics, may range in scale from a detailed map of the full set of neurons and synapses within part or all of the nervous system of an organism to a macro scale description of the functional and structural connectivity between all cortical areas and subcortical structures. (wikipedia.org)
  • The Drosophila connectome, once completed, will be a complete list of the roughly 135,000 neurons in the brain of the fruit fly Drosophila melanogaster, along with all of the connections (synapses) between these neurons. (wikipedia.org)
  • A high-level connectome, at the level of brain compartments and interconnecting tracts of neurons, exists for the full fly brain. (wikipedia.org)
  • The connectome naturally places strong constraints on which neurons or neural populations can interact, or how strong or direct their interactions are. (scholarpedia.org)
  • Here we present a theoretical framework and a data-driven algorithmic strategy to digitally reconstruct the complete synaptic connectivity between the different types of neurons in a small well-defined volume of tissue-the micro-scale connectome of a neural microcircuit. (frontiersin.org)
  • The connectome, Seung explained, is the totality of the connections among the human brain's 100 billion neurons . (cleveland.com)
  • More recently, some scientists have championed the importance of connectomes- detailed wiring diagrams of all the connections between neurons in a given nervous system or brain . (scientificamerican.com)
  • The standard way of making a connectome is serial electron microscopy-chopping up an animal's brain into thin sheets, taking photos of all the resident neurons through an electron microscope and using those photos to painstakingly reconstruct the connections between neurons. (scientificamerican.com)
  • Since mammalian brains contain millions or billions of neurons and billions or trillions of synapses, depending on the species, researchers are searching for faster and cheaper ways to create connectomes. (scientificamerican.com)
  • Curiously, the connectome of the mouse interscutularis - a muscle also found in dogs, rats, and other mammals that readily move their ears - reveals that some of its neurons are as much as 25 percent longer than is necessary. (harvard.edu)
  • The completed connectome of C. elegans maps its 300 neurons and roughly seven thousand synaptic connections. (news-medical.net)
  • The connectome gives the anatomical underpinning of the graded tensions elicited by motor neurons according to Henneman's size principle. (blogspot.com)
  • The connectome will significantly increase our understanding of how functional brain states emerge from their underlying structural substrate, and will provide new mechanistic insights into how brain function is affected if this structural substrate is disrupted. (wikipedia.org)
  • Regardless of the anatomical connectivity-i.e., patterns of morphological synaptic connections-there is so much functional plasticity that the anatomical connectome tells you almost nothing of functional relevance. (scienceblogs.com)
  • Despite such complex and variable structure-function mappings, the connectome is an indispensable basis for the mechanistic interpretation of dynamic brain data, from single-cell recordings to functional neuroimaging . (scholarpedia.org)
  • Here we integrate anatomical and functional connectivity measurements with behavioural assays to create a global model of the face connectome. (nih.gov)
  • Functional connectomes reveal biomarkers of individual psychological or clinical traits. (inria.fr)
  • Here, we consider a specific type of studies, using predictive models on the edge weights of functional connectomes, for which we highlight the best modeling choices. (inria.fr)
  • For each step we benchmark typical choices: 8 different ways of defining regions -either pre-defined or generated from the rest-fMRI data- 3 measures to build functional connectomes from the extracted time-series, and 10 classification models to compare functional interactions across subjects. (inria.fr)
  • The ability to uniquely characterize individual subjects based on their functional connectome (FC) is a key requirement for progress towards precision neuroscience . (springer.com)
  • Functional connectome fingerprinting: identifying individuals using patterns of brain connectivity. (springer.com)
  • Connectotyping: model based fingerprinting of the functional connectome. (springer.com)
  • Li K., Atluri G. (2018) Towards Effective Functional Connectome Fingerprinting. (springer.com)
  • However, little is known about the topological properties of the functional brain connectome of patients with OSA. (dovepress.com)
  • This study aimed to use the graph theory approaches to investigate the topological properties and functional connectivity (FC) of the functional connectome in patients with OSA, based on resting-state functional magnetic resonance imaging (rs-fMRI). (dovepress.com)
  • The automated anatomical labeling (AAL) atlas was used to construct the functional brain connectome. (dovepress.com)
  • The findings suggest that the functional connectome of patients with OSA exhibited disrupted functional integration and segregation, and functional disconnections of the DMN, SN, and CEN. (dovepress.com)
  • Here, we present an extensive functional connectome of Drosophila melanogaster's central complex at cell-type resolution. (elifesciences.org)
  • We illustrate the physiological relevance of the learned prior, that can be identified as a functional connectivity atlas, based on an experiment on 46 subjects of the Human Connectome Dataset. (springer.com)
  • Much of the human brain connectome has been assessed using magnetic resonance imaging (MRI) where functional MRI and diffusion MRI (dMRI) can measure correlated neural activity and structural connectivity of the brain in vivo, respectively [ 1 , 2 ]. (biomedcentral.com)
  • Connectomics is the study of the brain's structural and functional connections between cells, which is visualized as a connectome. (news-medical.net)
  • In order to understand how each nerve cell integrates into the functional organization of a neural circuit, it is necessary to obtain the complete wiring diagram (connectome) of the circuit by tracing out all the neural processes in the sample. (blogspot.com)
  • This work will be integral part of the collaborative HCP effort to construct a map of the human connectome that represents the structural and functional connections in vivo within a brain and across individuals. (grantome.com)
  • Led by Michael Hart , a PhD candidate at the Brain Mapping Unit in the Department of Psychiatry, the team from Cambridge conducted a series of resting-state functional MRI studies to construct the connectome , or the 'wiring diagram' of the brain in a group of patients with brain tumours. (cam.ac.uk)
  • Connectomics" (Hagmann, 2005) has been defined as the science concerned with assembling and analyzing connectome data sets. (wikipedia.org)
  • Connectome research (connectomics) has a number of competing objectives. (wikipedia.org)
  • Berning and colleagues from the Department of Connectomics at the Frankfurt-based Max Planck Institute for Brain Research developed a novel toolset, called SegEM, which speeds up connectome analysis by more than 10-fold. (neurosciencenews.com)
  • This meeting will explore how connectomes can be best utilized by bringing together experts spanning the range of expertise required to make use of connectomics, including systems neuroscientists, computational modelers, and theoreticians. (janelia.org)
  • Recent successes in the field of connectomics will be covered as well as computational methods for modeling connectomes, ranging from statistical modeling of graphs and networks to dynamical neural network modeling. (janelia.org)
  • and -a big one- linking genetics and connectomics (what are the genes that rule our connectome? (dutchconnectomelab.nl)
  • The connectome is a map of all neural connections in a brain and connectomics is the mapping of these connections. (news-medical.net)
  • The C. elegans connectome was later revised and expanded across development. (wikipedia.org)
  • The C. elegans connectome should be discussed more completely, as it is the only connectome that has been found so far. (scholarpedia.org)
  • Network control principles predict neuron function in the Caenorhabditis elegans connectome. (nih.gov)
  • C. elegans connectome. (nih.gov)
  • We conclude that an algorithmic approach to the connectome can serve as a tool to accelerate experimental mapping, indicating the minimal dataset required to make useful predictions, identifying the datasets required to improve their accuracy, testing the feasibility of experimental measurements, and making it possible to test hypotheses of synaptic connectivity. (frontiersin.org)
  • In a similar manner, one could consider the brain connectome, set of all neuronal connections, as one single entity, thus emphasizing the fact that the huge brain neuronal communication capacity and computational power critically relies on this subtle and incredibly complex connectivity architecture. (wikipedia.org)
  • The online macaque cortex connectivity tool CoCoMac (Kötter, 2004) and the temporal lobe connectome of the rat are prominent examples of such a database. (wikipedia.org)
  • In the human brain, the significance of the connectome stems from the realization that the structure and function of the human brain are intricately linked, through multiple levels and modes of brain connectivity. (wikipedia.org)
  • In this work, we modeled the structural connectome using diffusion tensor imaging in a sample of 949 youths (aged 8-22 y, 428 males and 521 females) and discovered unique sex differences in brain connectivity during the course of development. (pnas.org)
  • The connectome is the complete description of the structural connectivity (the physical wiring) of an organism's nervous system . (scholarpedia.org)
  • It has been suggested, simultaneously and independently by Sporns and Hagmann, to call the full connectivity structure (the connection set) of an organism's brain the connectome (Sporns et al. (scholarpedia.org)
  • I will present recent works that show (1) how manifolds learning techniques applied to whole-brain diffusion MRI connectomes can identify smooth gradients of structural connectivity variations and how they can predict time-varying changes in neural function. (mcgill.ca)
  • I will furthermore show (2) how they can be used for tracking neurodevelopment and for the prediction of cognitive maturation during adolescence, and finally (3) how they can index connectome-level perturbations in autism spectrum conditions, a prevalent and persistent condition of brain connectivity. (mcgill.ca)
  • The global structural connectivity of the brain, the human connectome, is now accessible at millimeter scale with the use of MRI. (epfl.ch)
  • The dutch connectome lab is a group of neuroscience enthusiasts with all kinds of backgrounds (biology, physics, math, medicine, artificial intelligence) working at the Complex Trait Genetics Lab and the center for neurogenomics and cognitive research , part of the Neurocience Campus Amsterdam, VU Amsterdam and Amsterdam UMC. (dutchconnectomelab.nl)
  • Appearances of Martijn van den Heuvel and the Dutch Connectome Lab in the media. (dutchconnectomelab.nl)
  • Get in touch with the Dutch Connectome Lab. (dutchconnectomelab.nl)
  • We propose to call this dataset the human "connectome," and we argue that it is fundamentally important in cognitive neuroscience and neuropsychology. (wikipedia.org)
  • Here, we compared structural brain connectomes defined by probabilistic tracts using diffusion magnetic resonance imaging data in Alzheimer's Disease Neuroimaging Initiative database and a brain transcriptome dataset covering 17 brain regions. (biomedcentral.com)
  • To demonstrate the capability of the novel gradient system, data of healthy adult participants were acquired for this MGH-USC Adult Diffusion Dataset ( N = 35), minimally preprocessed, and shared through the Laboratory of Neuro Imaging Image Data Archive (LONI IDA) and the WU-Minn Connectome Database (ConnectomeDB). (harvard.edu)
  • As of 2020, the Drosophila connectome is a work in progress, being obtained by the methods of neural circuit reconstruction. (wikipedia.org)
  • In 2020, a dense connectome of half the central brain of Drosophila was released, along with a web site that allows queries and exploration of this data. (wikipedia.org)
  • This work is highly significant because it studies a very large population of 949 youths (8-22 y, 428 males and 521 females) using the diffusion-based structural connectome of the brain, identifying novel sex differences. (pnas.org)
  • In this paper, we describe an approach to map the connectome by constructing normalized whole-brain structural connection matrices derived from diffusion MRI tractography at 5 different scales. (epfl.ch)
  • This is why Seung describes the effort to map the human connectome as "one of the greatest technological challenges of all time," and asserts that it will "take generations to succeed. (biomedicalcomputationreview.org)
  • Five years later, Seung elaborates in "Connectome," his bracing, mind-expanding report from neuroscience's razor edge. (cleveland.com)
  • Accessible, witty, imminently logical and at times poetic, "Connectome" establishes Seung as an important new researcher, philosopher and popularizer of brain science. (cleveland.com)
  • Since the connectome defines the pathways along which neural activity can flow, we might regard it as the streambed of consciousness," Seung writes. (cleveland.com)
  • Even more than our genome, our connectome shapes who we are, says Seung, who outlines his vision for connectome research in a new book, Connectome , published this month by Houghton Mifflin Harcourt. (scitechdaily.com)
  • We call this neuronal ensemble the "gut connectome" and summarize the work from a food sensory perspective. (jci.org)
  • Socioeconomic disadvantage is associated with atypical development in specific brain regions, yet the relation between poverty and whole brain network organization (i.e., the connectome, a set of brain regions connected with neuronal pathways) has not been characterized. (escholarship.org)
  • The key is integrating normal behaviors into the connectome, to see neuronal activity during normal states. (news-medical.net)
  • Research has successfully constructed the full connectome of one animal: the roundworm Caenorhabditis elegans, beginning with the first electron micrographs published by White, Brenner et al. (wikipedia.org)
  • A full connectome of a large portion of the central brain is likewise available. (wikipedia.org)
  • By understanding individual connectomes, they hope to gain a better understanding of how people become who they are. (scitechdaily.com)
  • How the edge weights from the individual connectomes will be combined. (pitgroup.org)
  • Many of the 76 compartments of the Drosophila brain have connectomes available, and the remainders are subjects of ongoing study. (wikipedia.org)
  • The comprehensive connectome of a neural substrate for 'ON' motion detection in Drosophila. (janelia.org)
  • Balázs Szalkai, Csaba Kerepesi, Bálint Varga, Vince Grolmusz, The Budapest Reference Connectome Server v2.0 , Neuroscience Letters , Vol. 595 (2015), Pages 60-62, http://dx.doi.org/10.1016/j.neulet.2015.03.071 . (pitgroup.org)
  • Workbench Command is a set of command-line tools that can be used to perform simple and complex operations within Connectome Workbench. (humanconnectome.org)
  • This post is a tutorial for getting started with Connectome Workbench 1.2.3 . (blogspot.se)
  • Our comprehensive connectome reveals complex circuits that include candidate anatomical substrates for both HR and BL types of motion detectors. (janelia.org)
  • These first-ever mammalian "connectomes," or complete neural circuit diagrams, reveal that neural wiring can vary widely even in paired tissues on the left and right sides of the same animal. (harvard.edu)
  • I published first work on the rich-club organization of the human connectome, describing a central backbone hub network in the mammalian brain that is not only well-connected to other parts of the brain but also amongst itself. (dutchconnectomelab.nl)
  • LICHTMAN: The word 'connectome' implies that the fundamentally important thing about brains is connections. (worldsciencefestival.com)
  • A connectome is also sometimes called a wiring diagram, wherein the brains axons and dendrites are analogous to wires and the neuron bodies to components. (news-medical.net)
  • Lichtman and Lu's work represents only the second connectome to date, following one for the worm Caenorhabditis elegans. (harvard.edu)
  • Comparison of each neuron and its counterpart on the opposite side of the animal revealed that each connectome was unique," Lichtman says, "demonstrating wiring diagrams that differ substantially in form, even within a common genetic background. (harvard.edu)
  • The connections between the cells are critical for brain function, so neuroscientists are keen to understand the structure of these circuits - the connectome - and to reconstruct it in a three-dimensional map. (mpg.de)
  • The generation of cellular resolution connectomes is rapidly advancing with recent examples of wiring diagrams from a variety of neural circuits and species. (janelia.org)
  • We reconstructed a comprehensive connectome of the circuits of Drosophila's motion-sensing T4 cells using a novel EM technique. (janelia.org)
  • Connectome" begins with a history lesson, recapping the 19th-century obsession among phrenologists to link the brain's size to intelligence, and moving into the 20th-century advances in deciphering neuron-to-neuron cross talk. (cleveland.com)
  • More broadly, a connectome would include the mapping of all neural connections within an organism's nervous system. (wikipedia.org)
  • In 2005, Dr. Olaf Sporns at Indiana University and Dr. Patric Hagmann at Lausanne University Hospital independently and simultaneously suggested the term "connectome" to refer to a map of the neural connections within the brain. (wikipedia.org)
  • The "connectome" article should be rewritten to truly focus on connections. (scholarpedia.org)
  • Our predictions are robust to deletions of weak connections, missing connections, and rewired connections in the current connectome, indicating the potential applicability of this analytical framework to larger and less well-characterized connectomes. (nih.gov)
  • The Connectome Coordination Facility (CCF) houses and distributes public research data for a series of studies that focus on the connections within the human brain. (humanconnectome.org)
  • Here we give an in-depth characterization of this connectome and propose a generative network model which utilizes two elemental organizational principles: proximal attachment ‒ outgoing connections are more likely to attach to nearby nodes than to distant ones, and source growth ‒ nodes with many outgoing connections are likely to form new outgoing connections. (elifesciences.org)
  • This map of the connections in the brain is called a connectome and it will allow doctors and scientists to better understand how the brain normally grows and also how problems might arise. (developingconnectome.org)
  • However, a connectome can provide a starting point by showing the static physical connections in place which underlie activity. (news-medical.net)
  • This file should contain one line per subject (Group1 + Group2), one column with the subject filename (only the file name, eg: file_for_Subj1.csv) and one extra column per regressor The Connectome Analyzer will select the best model that fits the values of each connection with the regressors, and remove the contribution of the regressors from the connections. (cmtk.org)
  • Join leading neuroscientists and psychologists as they explore how the connectome promises to revolutionize treatments for psychiatric and neurological disorders, answer profound questions regarding the electrochemical roots of memory and behavior, and clarify the link between our upbringing and brain development. (worldsciencefestival.com)
  • Here we fill this gap by applying a control framework to the connectome of the nematode Caenorhabditis elegans, allowing us to predict the involvement of each C. elegans neuron in locomotor behaviours. (nih.gov)
  • Budapest Reference Connectome version 2.0 is a parameterizable consensus brain graph. (pitgroup.org)
  • Click Download graph to download the reference connectome as CSV or GraphML. (pitgroup.org)
  • Click Download graph to download your custom connectome. (pitgroup.org)
  • View a parameterizable connectome (brain graph). (pitgroup.org)
  • Analyzing the adult mouse connectome revealed a number of unexpected properties. (elifesciences.org)
  • Using this information, Henriksen, Pang and Wronkiewicz attempted to 'grow' a virtual mouse connectome from scratch using two simple rules deduced from the properties of the adult connectome. (elifesciences.org)
  • Could scientists even foretell where and when pathology will surface just by looking at the connectome of a healthy person? (alzforum.org)
  • Some scientists question the wisdom of devoting scarce resources to the pursuit of the human connectome when the task remains well beyond the scope of currently available technologies. (biomedicalcomputationreview.org)
  • Scientists so far have managed to map the connectome of only one organism: the humble, raindrop-small roundworm C. elegans . (cleveland.com)
  • The scientists created the connectome, or map of brain circuitry, by performing an MRI scan of the brain of a healthy mouse at spatial resolution more than 100,000 times greater than that of a conventional clinical MRI. (healthcanal.com)
  • Duke researchers are currently building an online portal for scientists around the world to access the connectome to guide their own research into mouse neurocircuitry. (healthcanal.com)
  • Some scientists even believe that by constructing a connectome, an individual's memories could be recalled. (news-medical.net)
  • Right now the only method for finding connectomes is 3d electron microscopy. (scholarpedia.org)
  • By stitching together 2-D cross sections of the tiny brain segment taken with a powerful electron microscope, a 3-D model of this bit of the rabbit connectome emerged. (cleveland.com)
  • Electron microscopy was used to build the connectome of C. elegans . (news-medical.net)
  • The exponential improvement in electron microscopy and artificial intelligence in visual discrimination makes the future of human connectomes positive. (news-medical.net)
  • While everyone's connectomes are different, extreme differences may account for mental disorders such as autism and schizophrenia. (scitechdaily.com)
  • The Royal Ballet's Connectome fuses abstract narrative with impressive visuals and vigorous athleticism. (crane.tv)
  • Here, I present novel approaches to model structural connectome data based on cutting edge manifold learning techniques that can capture gradients of macroscale neural organization. (mcgill.ca)
  • Applications are sought that will apply the Human Connectome data collection protocol to disease/disorder cohorts of interest to the Institutes and Centers that are participating in this FOA. (nih.gov)
  • We have released and maintain a set of open-source Connectome software that supports browsing, download, exploration, visualization and analysis of HCP data. (humanconnectome.org)
  • The participant data from our research into the Human Connectome that is stored in our XNAT server is de-identified, and contains no personal health information (PHI). (humanconnectome.org)
  • In this work, we propose a simple yet effective solution to the problem of connectome inference in calcium imaging data. (arxiv.org)
  • With at our disposal a steadily growing volume of publicly available neuroimaging data, it is however possible to improve the estimation procedures involved in connectome mapping. (springer.com)
  • This suggests that gyrification-based connectomes could be a means to generate systems-based measures from anatomic data to advance the prediction of transition to psychosis in clinical high-risk (CHR) individuals. (psychiatryadvisor.com)
  • Analysis of the brain connectome by genomic data, tissue-tissue transcriptional synchronization between 17 brain regions, indicates that the regions connected by AD-associated tracts were likely connected at the transcriptome level with high number of tissue-to-tissue correlated (TTC) gene pairs ( P = 0.03). (biomedcentral.com)
  • In summary, our study suggests that brain connectomes defined by MRI and transcriptome data overlap with each other. (biomedcentral.com)
  • Use of MR Imaging-defined Connectome to Predict the Recovery of Patients after Cardiac Arrest. (diva-portal.org)
  • Third, by using topologic measures of the gyrification connectome, the researchers were able to predict the future outcome of a transition to psychosis with 81.34% balanced accuracy. (psychiatryadvisor.com)
  • Connectomes from a mouse's two interscutularis muscles depict dramatically different neural circuitry even within mirror-image tissues from the same animal. (harvard.edu)
  • Axons in the connectomes of the left and right interscutularis muscles of a 1-month old animal were colour-coded based on the rank-order of their motor unit sizes (the number of muscle fibres innervated by each axon) in each connectome. (blogspot.com)
  • Home / School of Clinical Medicine / Department of Psychiatry / News / Mapping the brain connectome before neurosurgery. (cam.ac.uk)
  • The human brain is structurally and functionally organized into connectome [ 13 , 14 ]. (hindawi.com)
  • In their 2005 paper, "The Human Connectome, a structural description of the human brain", Sporns et al. (wikipedia.org)
  • In a new essay, Anthony Zador of Cold Spring Harbor Laboratory has outlined what could be the fastest and cheapest way to construct a connectome yet-if he and his teammates surmount some significant hurdles. (scientificamerican.com)
  • Childhood poverty and the organization of structural brain connectome. (escholarship.org)
  • The term "connectome" is used primarily in scientific efforts to capture, map, and understand the organization of neural interactions within the brain. (wikipedia.org)