Connectome: A comprehensive map of the physical interconnections of an organism's neural networks. This modular organization of neuronal architecture is believed to underlie disease mechanisms and the biological development of the CENTRAL NERVOUS SYSTEM.Agenesis of Corpus Callosum: Birth defect that results in a partial or complete absence of the CORPUS CALLOSUM. It may be isolated or a part of a syndrome (e.g., AICARDI'S SYNDROME; ACROCALLOSAL SYNDROME; ANDERMANN SYNDROME; and HOLOPROSENCEPHALY). Clinical manifestations include neuromotor skill impairment and INTELLECTUAL DISABILITY of variable severity.Nerve Net: A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.Neural Pathways: Neural tracts connecting one part of the nervous system with another.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Models, Neurological: Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Brain Mapping: Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.Diffusion Tensor Imaging: The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.Image Processing, Computer-Assisted: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Frontotemporal Dementia: The most common clinical form of FRONTOTEMPORAL LOBAR DEGENERATION, this dementia presents with personality and behavioral changes often associated with disinhibition, apathy, and lack of insight.Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.Frontotemporal Lobar Degeneration: Heterogeneous group of neurodegenerative disorders characterized by frontal and temporal lobe atrophy associated with neuronal loss, gliosis, and dementia. Patients exhibit progressive changes in social, behavioral, and/or language function. Multiple subtypes or forms are recognized based on presence or absence of TAU PROTEIN inclusions. FTLD includes three clinical syndromes: FRONTOTEMPORAL DEMENTIA, semantic dementia, and PRIMARY PROGRESSIVE NONFLUENT APHASIA.Geographic Atrophy: A form of MACULAR DEGENERATION also known as dry macular degeneration marked by occurrence of a well-defined progressive lesion or atrophy in the central part of the RETINA called the MACULA LUTEA. It is distinguishable from WET MACULAR DEGENERATION in that the latter involves neovascular exudates.Aphasia, Primary Progressive: A progressive form of dementia characterized by the global loss of language abilities and initial preservation of other cognitive functions. Fluent and nonfluent subtypes have been described. Eventually a pattern of global cognitive dysfunction, similar to ALZHEIMER DISEASE, emerges. Pathologically, there are no Alzheimer or PICK DISEASE like changes, however, spongiform changes of cortical layers II and III are present in the TEMPORAL LOBE and FRONTAL LOBE. (From Brain 1998 Jan;121(Pt 1):115-26)Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.Carcinoma, Brown-PearceHIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Allergy and Immunology: A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.HIV-1: The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Biological Evolution: The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Fossils: Remains, impressions, or traces of animals or plants of past geological times which have been preserved in the earth's crust.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Portraits as Topic: Graphic representations, especially of the face, of real persons, usually posed, living or dead. (From Thesaurus for Graphic Materials II, p540, 1995)Neuroanatomy: Study of the anatomy of the nervous system as a specialty or discipline.Neurosciences: The scientific disciplines concerned with the embryology, anatomy, physiology, biochemistry, pharmacology, etc., of the nervous system.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Transducers: Any device or element which converts an input signal into an output signal of a different form. Examples include the microphone, phonographic pickup, loudspeaker, barometer, photoelectric cell, automobile horn, doorbell, and underwater sound transducer. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)Metabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Photography: Method of making images on a sensitized surface by exposure to light or other radiant energy.Biosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.Photons: Discrete concentrations of energy, apparently massless elementary particles, that move at the speed of light. They are the unit or quantum of electromagnetic radiation. Photons are emitted when electrons move from one energy state to another. (From Hawley's Condensed Chemical Dictionary, 11th ed)Newspapers: Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)Mass Media: Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.Hammer Toe Syndrome: A condition characterized by a series of interrelated digital symptoms and joint changes of the lesser digits and METATARSOPHALANGEAL JOINTS of the FOOT. The syndrome can include some or all of the following conditions: hammer toe, claw toe, mallet toe, overlapping fifth toe, curly toe, EXOSTOSIS; HYPEROSTOSIS; interdigital heloma, or contracted toe.Nails: The thin, horny plates that cover the dorsal surfaces of the distal phalanges of the fingers and toes of primates.Nail Diseases: Diseases of the nail plate and tissues surrounding it. The concept is limited to primates.Bone Nails: Rods of bone, metal, or other material used for fixation of the fragments or ends of fractured bones.Construction Industry: The aggregate business enterprise of building.Molecular Dynamics Simulation: A computer simulation developed to study the motion of molecules over a period of time.Caenorhabditis elegans: A species of nematode that is widely used in biological, biochemical, and genetic studies.Caenorhabditis elegans Proteins: Proteins from the nematode species CAENORHABDITIS ELEGANS. The proteins from this species are the subject of scientific interest in the area of multicellular organism MORPHOGENESIS.Nonlinear Dynamics: The study of systems which respond disproportionately (nonlinearly) to initial conditions or perturbing stimuli. Nonlinear systems may exhibit "chaos" which is classically characterized as sensitive dependence on initial conditions. Chaotic systems, while distinguished from more ordered periodic systems, are not random. When their behavior over time is appropriately displayed (in "phase space"), constraints are evident which are described by "strange attractors". Phase space representations of chaotic systems, or strange attractors, usually reveal fractal (FRACTALS) self-similarity across time scales. Natural, including biological, systems often display nonlinear dynamics and chaos.Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Dancing: Rhythmic and patterned body movements which are usually performed to music.Eidetic Imagery: A visual image which is recalled in accurate detail. It is a sort of projection of an image on a mental screen.Tarsal Joints: The articulations between the various TARSAL BONES. This does not include the ANKLE JOINT which consists of the articulations between the TIBIA; FIBULA; and TALUS.Literature, ModernGymnastics: Systematic physical exercise. This includes calisthenics, a system of light gymnastics for promoting strength and grace of carriage.Oligomenorrhea: Abnormally infrequent menstruation.

Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surface-based atlases. (1/116)

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Cortical parcellations of the macaque monkey analyzed on surface-based atlases. (2/116)

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The anatomical distance of functional connections predicts brain network topology in health and schizophrenia. (3/116)

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Functional organization of the neural language system: dorsal and ventral pathways are critical for syntax. (4/116)

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Identifying behavioral circuits in Drosophila melanogaster: moving targets in a flying insect. (5/116)

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Functional connectivity measured with magnetoencephalography identifies persons with HIV disease. (6/116)

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The Human Connectome Project: a data acquisition perspective. (7/116)

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Building retinal connectomes. (8/116)

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The functioning of the human brain relies on the interplay and integration of numerous individual units within a complex network. To identify network configurations characteristic of specific cognitive tasks or mental illnesses, functional connectomes can be constructed based on the assessment of synchronous fMRI activity at separate brain sites, and then analyzed using graph-theoretical concepts. In most previous studies, relatively coarse parcellations of the brain were used to define regions as graphical nodes. Such parcellated connectomes are highly dependent on parcellation quality because regional and functional boundaries need to be relatively consistent for the results to be interpretable. In contrast, dense connectomes are not subject to this limitation, since the parcellation inherent to the data is used to define graphical nodes, also allowing for a more detailed spatial mapping of connectivity patterns. However, dense connectomes are associated with considerable computational demands in
TY - JOUR. T1 - Functional connectome of the striatal medium spiny neuron. AU - Chuhma, Nao. AU - Tanaka, Kenji F.. AU - Hen, René. AU - Rayport, Stephen. PY - 2011/1/26. Y1 - 2011/1/26. N2 - Dopamine system disorders ranging from movement disorders to addiction and schizophrenia involve striatal medium spiny neurons (MSNs), yet their functional connectivity has been difficult to determine comprehensively. We generated a mouse with conditional channelrhodopsin-2 expression restricted to medium spiny neurons and assessed the specificity and strength of their intrinsic connections in the striatum and their projections to the globus pallidus and the substantia nigra. In the striatum, medium spiny neurons connected with other MSNs and tonically active cholinergic interneurons, but not with fast-spiking GABA interneurons. In the globus pallidus, medium spiny neurons connected strongly with one class of electrophysiologically identified neurons, but weakly with the other. In the substantia nigra, ...
The member universities of the Human Connectome Project take privacy very seriously, whether dealing with participant data or the data of those visiting this website. The participant data from our research into the Human Connectome that is stored in our XNAT server is de-identified, and contains no personal health information (PHI). Our website collects names and email addresses via our contact form. This information is used solely by the administrators and members of the HCP website and is not shared, traded or sold to third parties under any circumstances. Our website may also collect non-personal data about site visits, sessions, and IP addresses. This information is only used for diagnostic or debugging purposes, to help us optimize our websites performance, and is not shared externally. This is a standard practice for most websites, and this data is never linked with personally identifiable information. This website contains links to other websites whose content we think is relevant. ...
The member universities of the Human Connectome Project take privacy very seriously, whether dealing with participant data or the data of those visiting this website. The participant data from our research into the Human Connectome that is stored in our XNAT server is de-identified, and contains no personal health information (PHI). Our website collects names and email addresses via our contact form. This information is used solely by the administrators and members of the HCP website and is not shared, traded or sold to third parties under any circumstances. Our website may also collect non-personal data about site visits, sessions, and IP addresses. This information is only used for diagnostic or debugging purposes, to help us optimize our websites performance, and is not shared externally. This is a standard practice for most websites, and this data is never linked with personally identifiable information. This website contains links to other websites whose content we think is relevant. ...
The Human Connectome Project (HCP) has developed protocols, standard operating and quality control procedures, and a suite of informatics tools to enable high throughput data collection, data sharing, automated data processing and analysis, and data mining and visualization. Quality control procedures include methods to maintain data collection consistency over time, to measure head motion, and to establish quantitative modality-specific overall quality assessments. Database services developed as customizations of the XNAT imaging informatics platform support both internal daily operations and open access data sharing. The Connectome Workbench visualization environment enables user interaction with HCP data and is increasingly integrated with the HCPs database services. Here we describe the current state of these procedures and tools and their application in the ongoing HCP study. © 2013 Elsevier Inc.
Spontaneous fluctuations in activity in different parts of the brain can be used to study functional brain networks. We review the use of resting-state functional MRI (rfMRI) for the purpose of mapping the macroscopic functional connectome. After describing MRI acquisition and image-processing methods commonly used to generate data in a form amenable to connectomics network analysis, we discuss different approaches for estimating network structure from that data. Finally, we describe new possibilities resulting from the high-quality rfMRI data being generated by the Human Connectome Project and highlight some upcoming challenges in functional connectomics.
The Human Connectome Project (HCP) relies primarily on three complementary magnetic resonance (MR) methods. These are: 1) resting state functional MR imaging (rfMRI) which uses correlations in the temporal fluctuations in an fMRI time series to deduce functional connectivity; 2) diffusion imaging (dMRI), which provides the input for tractography algorithms used for the reconstruction of the complex axonal fiber architecture; and 3) task based fMRI (tfMRI), which is employed to identify functional parcellation in the human brain in order to assist analyses of data obtained with the first two methods. We describe technical improvements and optimization of these methods as well as instrumental choices that impact speed of acquisition of fMRI and dMRI images at 3T, leading to whole brain coverage with 2 mm isotropic resolution in 0.7 s for fMRI, and 1.25 mm isotropic resolution dMRI data for tractography analysis with three-fold reduction in total dMRI data acquisition time. Ongoing technical developments
Analysing computations in neural circuits often uses simplified models because the actual neuronal implementation is not known. For example, a problem in vision, how the eye detects image motion, has long been analysed using Hassenstein-Reichardt (HR) detector or Barlow-Levick (BL) models. These both simulate motion detection well, but the exact neuronal circuits undertaking these tasks remain elusive. We reconstructed a comprehensive connectome of the circuits of Drosophilas motion-sensing T4 cells using a novel EM technique. We uncover complex T4 inputs and reveal that putative excitatory inputs cluster at T4s dendrite shafts, while inhibitory inputs localize to the bases. Consistent with our previous study, we reveal that Mi1 and Tm3 cells provide most synaptic contacts onto T4. We are, however, unable to reproduce the spatial offset between these cells reported previously. Our comprehensive connectome reveals complex circuits that include candidate anatomical substrates for both HR and BL ...
Additional notes. Improved atlas surfaces and myelin maps. The Conte69 atlas dataset was derived from Freesurfer segmentation, surface reconstruction, and registration to the fsaverage left and right hemispheres, followed by interhemispheric registration to the left-right hybrid atlas, bringing the two hemispheres into geographic correspondence [1]. The current data release benefits from several refinements in surface generation and in the myelin mapping algorithm compared to the published data [1, 2]. Connectome Workbench data format. The Conte69 atlas dataset is also available in the new Connectome Workbench data format being developed for the Human Connectome Project. A beta-release of Connectome Workbench will be made available in the summer of 2012. REFERENCES. ...
We interview Alastair Marriott with his work and life partner Jonathan Howells to talk choreography and neuroscience. The pair met as students at the Royal Ballet School but only began working together on professional projects recently. As choreographer, Marriott takes the lead while a work is initially developed. He explores ideas on his own before sharing them with dancers in a studio where their reactions influence the work. Once the principal shape of the choreography is determined Howells takes over and directs rehearsals. He must learn all the dancers movements and communicate Marriotts desired nuances and aesthetic. This allows to Marriott take some distance during rehearsals; keeping his eye sharp for fine-tuning.. Marriotts ballet, Connectome, explores the theory that every individual has a unique mental map that is shaped and coloured by events in their life. As a project of neuroscience, mental mapping remains largely underdeveloped so as creative stimulus it provides huge scope for ...
Recently the relation among activated human brain regions has drawn interests and has been investigated The imaging technique of functional magnetic resonance imagimg (fMRI) can be used to observe by changes in cerebral blood oxygenation and therefore brain connectivity To understand how white matter (WM) tractography influences brain connectivity we use diffusion magnetic resonance imagimg (dMRI) technique and algorithm to calculate WM map The connectivity measurement combining fMRI and dMRI datasets is called anatomically weighted functional connectivity (awFC) Finally the results show that when using awFC datasets the clusters have higher functional connectivity (FC) and structural connectivity (SC) strength when using awFC datasets ...
You are unique, just like everyone else.. Connectomics is the study of the structural and functional connections among brain cells; its product is the "connectome," a detailed map of those connections. The idea is that such information will be monumental in our understanding of the healthy and diseased brain. Sebastian Seung thinks that a complete connectome of the human brain will be one of the great prizes in 21st-century neuroscience.. Efforts to construct brain connectomes are split into two categories: ones that use imaging techniques like MRI, PET, and DT, thus focusing on macroscopic connections or tracts; and those that use electron microscopy to map the tinniest of axons (0.2-20 microns in diameter) and individual synapses.. While this may sound daunting, it also seems the obvious thing to do in order to really understand how the brain works. After all, dont all our memories, personalities, and behaviors dependent on the structure of the brain, down to the microscopic level? So why is ...
TY - JOUR. T1 - The beginning of connectomics. T2 - A commentary on White et al. (1986) The structure of the nervous system of the nematode Caenorhabditis elegans. AU - Emmons, Scott W.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - The article Structure of the nervous system of the nematode Caenorhabditis elegans (aka The mind of a worm) by White et al., published for the first time the complete set of synaptic connections in the nervous system of an animal. The work was carried out as part of a programme to begin to understand how genes determine the structure of a nervous system and how a nervous system creates behaviour. It became a major stimulus to the field of C. elegans research, which has since contributed insights into all areas of biology. Twenty-six years elapsed before developments, notably more powerful computers, made new studies of this kind possible. It is hoped that one day knowledge of synaptic structure, the connectome, together with results of many other investigations, will lead ...
While maps of young adult brains will be informative, several audience members expressed interest in seeing a developmental time course of brain connectivity. At the moment, looking at younger brains or healthy older brains is beyond the scope of the project, said Story Landis, who directs the National Institute for Neurological Disorders and Stroke. If the community embraces the current database, however, future projects to look at connectivity in other populations might get funded, she added. Since equipment and infrastructure are now in place, such add-on projects would have a smaller price tag, Landis pointed out. Many researchers in the Alzheimers field have shown that brain connectivity in key regions decreases as the disease advances, making this a hot topic for AD research (see ARF related news story; ARF news story; and ARF news story).. This project will be an important step in developing connectivity methods that can be used in AD research. The methods have great potential, and a ...
The exploration of the human connectome, a term denoting the global structural connectivity of the brain, is accessible to MRI at millimeter and centimeter scales. In this paper, we propose a methodology to map the connectome by constructing normalized whole-brain structural connection matrices derived from diffusion spectrum MRI tractography. Using a template-based approach, we propose a robust method that allows a) the selection of identical cortical regions of interest in different subjects with identification of the associated fiber tracts, b) a straightforward construction and interpretation of anatomically organized whole-brain connection matrices, and c) a statistical inter-subject comparison of brain connectivity.. Keywords: LTS5 ; diffusion MRI ; tractography ; connectivity. ...
In this work, we applied a multi-objective evolutionary approach to rewire brain networks and place them within an efficiency-complexity morphospace. Using various Pareto-optimal selection criteria, we were able to explore how brain networks evolve when subject to distinct selection pressures. Furthermore, the approach allowed us to investigate relationships and trade-offs between distinct topological traits associated with the principal axes of the morphospace, Ediff, Erout and CN. Our results demonstrate that the empirical networks we used as seed points for evolution are surrounded by a large space of variant network topologies, even when holding wiring cost constant, including networks that combine a higher capacity to support efficient communication with higher neural complexity.. Our work attempts to make several methodological contributions. First, building on fundamental work in evolutionary theory [44,51,52], we extend the morphospace analysis framework into the realm of human brain ...
Much of the CD4+ T-cell death that occurs during HIV infection may be caused by direct delivery of the virus from neighboring cells, a study shows.. 0 Comments. ...
Manipulate the default connectome provided with TVB to see how structural lesions effect brain dynamics. In this hands-on session you will insert lesions into the connectome within the TVB graphical user interface. Afterwards the modified connectome will be used for simulations and the resulting activity will be analysed using functional connectivity. ...
Manipulate the default connectome provided with TVB to see how structural lesions effect brain dynamics. In this hands-on session you will insert lesions into the connectome within the TVB graphical user interface. Afterwards the modified connectome will be used for simulations and the resulting activity will be analysed using functional connectivity. ...
We have just published a manuscript in PLoS Biology where we describe how to build a complete and accurate neural network. This of course is one of the long standing holy grails in neuroscience. So, this effort meets two goals: 1) It meets the goals of building a complete neural connectome (well be finished collecting all of the data with cell identity, physiologic response and all synaptic connectivity in approximately six days) and 2) It defines a workflow whereby investigators from around the planet can download and use the tools we are providing to build their own connectome projects using existing infrastructure. We are making those tools available here to enable other groups to assemble, browse and annotate the terabyte sized datasets required of connectome level projects.. The breakthroughs in this effort have largely centered on building a framework that can deal with ultrastructural image capture using Transmission Electron Microscopy (TEM) but greatly accelerates the data capture and ...
I would like to propose a metaphor for the relationship between neural activity and connectivity. Neural activity is constantly changing. Its like the water of the stream; it never sits still. The connections of the brains neural network determines the pathways along which neural activity flows. And so the connectome is like bed of the stream; but the metaphor is richer than that, because its true that the stream bed guides the flow of the water, but over long timescales, the water also reshapes the bed of the stream. And as I told you just now, neural activity can change the connectome. And if youll allow me to ascend to metaphorical heights, I will remind you that neural activity is the physical basis - or so neuroscientists think - of thoughts, feelings and perceptions. And so we might even speak of the stream of consciousness. Neural activity is its water, and the connectome is its bed ...
Despite recent advances, the tissue clearing technologies have a fundamental limitation: the working distance of optical microscopy. Without physical sectioning, an objective lens with high numerical aperture (≥1.2) for resolving submicron-resolution details does not have enough working distance (≥0.28 mm) to visualize cellular structures that are more than several millimeters deep. This limitation can be partially addressed by shrinkage-mediated imaging, which reduces the tissue volume after clearing (Pan et al., 2016). However, serial sectioning is still required for 3D imaging and reconstruction of large tissues.. Serial sectioning has been used with transmission EM to reconstruct the whole-body connectome of Caenorhabditis elegans (White et al., 1986; Xu et al., 2013) and larval Drosophila (Ohyama et al., 2015) as well as the partial optic medulla connectome in Drosophila (Takemura et al., 2013). However, the use of transmission EM in connectome reconstruction is limited by the ...
Because of the unique position of the topologically central role of densely interconnected brain hubs, our study aimed to investigate whether these regions and their related connections would be...
Abnormal rich-club metrics are a characteristic feature of PI-related to disease severity. These metrics provide potential clues to PI pathogenesis and may be useful as diagnostic markers and for assessment of treatment response.
For example, one discipline that has been quickly expanding and receiving much attention from the media is connectomics. The aim of this field is to create detailed maps, or connectomes, of all synaptic connections among neurons. This stands in contrast to other more conventional approaches that interrogate specific pathways and networks of connections among a restricted group of neurons. The generation of these connectomes has been strongly pursued through the development of techniques for high-resolution, high-throughput reconstruction of small volumes of nervous tissue. For example, recent work by Kasthuri et al (2015) shows the potential of new electron microscopy (EM) techniques for expanding our understanding of the connections and structure of the brain. Unlike other forms of histology that rely on fluorescence to visualize cells, EM generates high-resolution images that reveal all membranous structures. Kasthuri and colleagues have imaged a square volume of brain slice after brain slice, ...
Markett, S., Montag, C., Heeren, B., Saryiska, R., Lachmann, B., Weber, B., & Reuter, M. (2016). Voxelwise eigenvector centrality mapping of the human functional connectome reveals an influence of the catechol-O-methyltransferase val158met polymorphism on the default mode and somatomotor network. Brain Structure and Function, 221(5), 2755-2765 ...
Neurons and their processes, color-coded to distinguish one from another. Credit: Lichtman Lab / Harvard University. The scale of the problem. Since the end of that project, Lichtmans lab has improved further the automation of imaging and analysis, and now, Lichtman says, could reconstruct the same-sized volume of brain tissue (0.0000015 cubic millimeters, or roughly one cell-width across) in a matter of months, not years.. Still, that is only a very tiny volume, on the order of a billionth of a whole mouse brain-or less than a trillionth of a human brain.. The enormity of the connectomics challenge is also apparent when one looks at the data storage requirements. The annotated imagery generated in Lichtmans project required about 3 trillion bytes (terabytes) of storage. According to Kasthuri, mapping a full human brain connectome would require more than 1021 bytes (one zettabyte), which represents a large fraction of the total storage capacity on Earth at present.. Connectomics research ...
Here, we examined the hypothesis that network controllability in the LIFG is related to language performance in tasks with open- and closed-ended response demands. We explicitly tested this hypothesis by linking variability in the vulnerability of controlled language function to perturbation by TMS to LIFG controllability. In this study, we integrated two separately developing theoretical frameworks from cognitive neuroscience and emerging applications of control theory to human brain networks (Gu et al., 2015). In cognitive neuroscience, the LIFG is identified as a site that mediates controlled language function; however, the mechanisms by which the LIFG executes this role in brain networks are unknown. Network control theory is postulated to be a useful framework to understand the organization for human cognitive control and performance variability based on the role of anatomical regions in the structural connectome (Gu et al., 2015, Tang et al., 2017).. To test this experimentally, we ...
Green Hope High School currently has over 100 different clubs and organizations to choose from. It is our hope that every student will find a group that interests them and gets involved! For further information, please email the Club Advisor listed.. All email addresses are "@wcpss.net" unless otherwise noted.. ...
On July 29, 2016, in the "Mindentudás" ("Omniscience") magazine, Hungarian Television Channel 1 (M1) aired a news block on our research: How to Direct the Edges of the Connectomes: Dynamics of the Consensus Connectomes and the Development of the Connections in the Human Brain ...
Csaba Kerepesi, Balázs Szalkai, Bálint Varga, Vince Grolmusz: How to Direct the Edges of the Connectomes: Dynamics of the Consensus Connectomes and the Development of the Connections in the Human Brain, PLoS One 11(6): e0158680. http://dx.doi.org/10.1371/journal.pone.0158680, June 30, 2016 [impact factor: 3.057 ...
PHILADELPHIA - A new brain connectivity study from Penn Medicine published today in the Proceedings of National Academy of Sciences found striking differences in the neural wiring of men and women thats lending credence to some commonly-held beliefs about their behavior.. In one of the largest studies looking at the "connectomes" of the sexes, Ragini Verma, PhD, an associate professor in the department of Radiology at the Perelman School of Medicine at the University of Pennsylvania, and colleagues found greater neural connectivity from front to back and within one hemisphere in males, suggesting their brains are structured to facilitate connectivity between perception and coordinated action. In contrast, in females, the wiring goes between the left and right hemispheres, suggesting that they facilitate communication between the analytical and intuition.. "These maps show us a stark difference-and complementarity-in the architecture of the human brain that helps provide a potential neural basis ...
(Medical Xpress)-If all you have is a hammer, everything looks like a nail. This so-called law of the instrument has shaped neuroscience to core. It can be rephrased as, if all you have a fancy voltmeter, everything ...
tadpole-spinal-cord-models This is the source code for three compuational models used for generating connectivity and swimming functionality of spinal cord neurons in the Xenopus tadpoles using biological data. 1. The first model uses biological data to reconstruct a complete map of synaptic interactions between spinal neuron (anatomical connectome), in the folder anatomical model. 2. The second model generalizes the anatomical model by averaging a number of anatomical connectomes and thus generating a matrix of connection probabilities between the neurons, in the folder probabilistic model. 3. The third model uses the previous two to generate connectivity between neurons and simulates the dynamics of this circuit using Neuron (tested with version 7.3), in the folder functional model. A README file contained in the folder of each piece of the model explains how to run the simulations and give a description of the models. For a more complete description of these models have a look at ...
If nothing else, this wiring diagram of the brain will provide a lot of data. What you might call big data. You need to look at every cubic millimeter of brain to see every synapse, which is necessary to map the brains connectome in full. "In a cubic millimeter of brain there is about two terabytes of image data," Lichtman says. "I think the original Google Maps was on the range of several terabytes - that was for the whole planet." As of August 2012, it was around 20 petabytes, or 20,500 terabytes, for satellite, aerial, and street imagery combined. A human brain has something on the order of a million cubic millimeters, which means youd need around two million terabytes to store a map of its wires. Two million terabytes is around two thousand petabytes, or two exabytes. "Thats a big number," Lichtman notes. "Even today. Even for Google." Its so big, even, that most people cannot fathom it. Even that 302-neuron C. elegans worm connectome is too much for most people, and its more on the ...
The neural dynamics of the nematode \emph{C. elegans} are experimentally low-dimensional and may be understood as long-timescale transitions between multiple low-dimensional attractors. Previous modeling work has found that dynamic models of the worms full neuronal network are capable of generating reasonable dynamic responses to certain inputs, even when all neurons are treated as identical save for their connectivity. This study investigates such a model of \emph{C. elegans} neuronal dynamics, finding that a wide variety of multistable responses are generated in response to varied inputs. Specifically, we generate bifurcation diagrams for all possible single-neuron inputs, showing the existence of fixed points and limit cycles for different input regimes. The nature of the dynamical response is seen to vary according to the type of neuron receiving input; for example, input into sensory neurons is more likely to drive a bifurcation in the system than input into motor neurons. As a specific example we
Conversely, it has been recently proposed that mental operations follow constrained, topological donutlike trajectories along preferential functional brain railways [20, 21, 22, 23, 24]. Experimental and theoretical clues allow us to conjecture that some brain activities are shaped in guise of a multidimensional torus. The theoretical claims of brain multidimensionality are widespread [3, 25, 26] as an example, models characterized by dimensionality reduction have been used in the study of human central nervous system [27]. It has been demonstrated that high dimensionality brain spontaneous activity structures occur, consisting of multiple, reproducible temporal sequences [28]. It has also been shown that the exceedingly diverse nonlinear selectivity in single-neuron activity in the prefrontal cortex is a signature of high-dimensional neural representations: crucially, this dimensionality is predictive of animal behaviour as it collapses in error trials [29]. In addition, recent findings suggest ...
The connectome is a term, coined in the past decade, that has been used to describe more than one phenomenon in neuroscience. Dr. R Clay Reid explains the basics of structural connections at the micro-, meso- and macroscopic scales.
Scientific discussion meeting organised by Dr John White FRS, Dr Stephen Larson, Dr Andre Brown, Dr William Schafer and Professor Netta Cohen
The Mural Arts Program is the nations largest public art program, dedicated to the belief that art ignites change. For nearly 30 years, the Mural Arts Program has united artists and communities through a collaborative process, rooted in the traditions of mural-making, to create art that transforms public spaces and individual lives. Mural Arts engages communities in 50 to 100 mural and public art projects each year, including a restoration program that maintains the collection. The murals also create unique project-based learning opportunities for thousands of youth and adults in the Art Education for Youth, Restorative Justice, and Behavioral Health programs. Each year, 14,000 residents and visitors tour the Mural Arts Programs outdoor art gallery, which has become part of the citys civic landscape and a source of pride and inspiration. The Mural Arts Program has created over 3,600 murals and works of public art, earning Philadelphia international recognition as the "City of Murals." ...
IV. EFFECTS OF CRYOPRESERVATION ON THE HISTOLOGY OF SELECTED TISSUES (Liver and Kidneys) Histology was evaluated in two animals each from the FIG and FIGP groups, and in one control animal. Only brain histology was evaluated in the straight-frozen control … Continue reading →. ...
Click on the second tab, then choose Volume in the View part of the menu to tell Workbench we want to see volumes (marked by red dots on the right side of the above image). When you click the Volume button the menus will change, but you wont actually see anything: unlike surfaces, you have to turn the volumetric underlay on as a Layer in the Overlay ToolBox. The red arrow points at the proper box: select one of the NIfTI images in the third box, and check its little On checkbox. You should now see a single slice. I wanted to see multiple slices, so clicked the On button in the Montage part of the menu (also marked by red dots in the above image). Try changing the settings in the Slice Plane, Montage, and Slice Indices/Coords parts of the menu to adjust the view (which slices, how many, which axis, etc ...
and squeezing them through apertures. Aperture size is critical as each contains a crossing of rays known as a focus. Large apertures blur: Each object point connects by straight rays to a spray of image points bounded by the upper and lower hole margins, forming a mess of misaligned foci. Decreasing aperture size reduces blurring, but small holes pass few photons and images are dimmed to uselessness. After all, one cannot "turn up" the Sun. And then there is spatial resolution to worry about. A sensor surface on which an image is cast ... whether eye, film or digital camera chip ... is composed of discrete sensing points, and image sharpness requires large sensors. A patch of 1000 sensing points will better define an image than one drawn by 100 points. In the camera obscura, images are enlarged by building bigger rooms. Doubling image area requires enlarging the room width from 10 feet to 14.14 feet from the aperture. But this new image is dimmer, with the same number of photons distributed ...
Diffusion Magnetic Resonance Imaging (MRI) provides unprecedented insights into the wiring of the human brain. This non-invasive imaging technique, introduced in the mid-1980s, uses diffusing water molecules as microscopic probes for the three dimensional structure of axonal pathways. Large international consortia such as the Human Connectome Project (HCP) are currently underway to exploit diffusion MRI, in conjunction with other structural and functional imaging modalities, and ultimately elucidate the brain circuitry. Diffusion MRI raises many mathematical and computational challenges, because of the complexity of the data and the need for adequate models. In this talk, I will give an overview of the basic concepts behind this imaging modality, address topics such as white matter fiber orientation mapping and tractography, and describe their application to the study of neurodegenerative diseases ...
TVB has been designed following a computational modeling paradigm that permits the model-based inference of network-based mechanisms on different brain scales that underlie the generation of macroscopic neuroimaging signals such as fMRI, EEG and MEG. TVB incorporates a biologically realistic, large-scale connectivity of brain regions in the primate brain, that is, the information of white matter neural fibre tracts as identified by tractography based methods (Hagmann et al., 2008, Honey et al., 2009, Bastiani et al., 2012), obtained from CoCoMac neuroinformatics database (Kötter, 2004, Kötter and Wanke, 2005), or from the recently structural connectivity datasets made available thanks to the Human Connectome Project (Essen and Ugurbil, 2012). Also, a realistic cortex model , as extracted from MRI data, is included. This approach allows a detailed spatial sampling, in particular of the cortical surface, resulting in suitable spatial support for an approximation of the neural activity as in ...
This paper in the Journal of Comparative Neurology by J. Scott Lauritzen, James R. Anderson, Bryan W. Jones, Carl B. Watt, Shoeb Mohammed, John V. Hoang and Robert E. Marc is another effort out of the Marc Laboratory For Connectomics that continues to define complete neural circuits to completeness. This paper is another elucidation of data from the first Rabbit Retinal Connectome volume (RC1) that reveals […]. ...
White matter fibres. Computer enhanced 3D diffusion spectral imaging (DSI) scan of the bundles of white matter nerve fibres in the brain. The fibres transmit nerve signals between brain regions and between the brain and the spinal cord. Diffusion spectrum imaging (DSI) is a variant of magnetic resonance imaging (MRI) in which a magnetic field maps the water contained in neuron fibers, thus mapping their criss-crossing patterns. A similar technique called diffusion tensor imaging (DTI) is also used to explore neural data of white matter fibres in the brain. Both methods allow mapping of their orientations and the connections between brain regions. Data/software: NIH Human Connectome Project / www.humanconnectomeproject.org). - Stock Image C018/6391
Understanding the amazingly complex human cerebral cortex requires a map (or parcellation) of its major subdivisions, known as cortical areas. Making an accurate areal map has been a century-old objective in neuroscience. Using multi-modal magnetic resonance imaging from the Human Connectome Project (HCP) and an objective semi-automated neuroanatomical approach, Glasser et al delineated 180 areas per hemisphere bounded by sharp changes in cortical architecture, function, connectivity, and/or topography in a precisely aligned group average of 210 healthy young adults. They characterized 97 new areas and 83 areas previously reported using post-mortem microscopy or other specialized study-specific approaches. To enable automated delineation and identification of these areas in new HCP subjects and in future studies, they trained a machine-learning classifier to recognize the multi-modal fingerprint of each cortical area. This classifier detected the presence of 96.6% of the cortical areas in new ...
My research involves the use of multimodal neuroimaging (MRI, MRA, PET, CT, EEG, MEG) to understand how traumatic brain injury (TBI) alters brain aging. Specific interests include (1) TBI in older adults; (2) aging- and TBI-related reorganization of the human connectome; (3) the relationship between TBI and Alzheimers disease; (4) consequences of aging and TBI upon neural function, cognition and affect (major depressive disorder); (5) cardiovascular disease effects upon brain aging in atypical populations (the Tsimane people of Bolivia ...
ketamine infusion therapy restores the human connectome, signs and symptoms of cerebral palsy cerebral palsy, how addictive behaviour is caused during pregnancy itself, essential pre writing skills i can trace lines liz 39 s, inb instituto de neurobiología unam
A browser check indicates that you do not have the Aspera Connect plugin installed, you have an older version installed that is no longer supported or Aspera has not been allowed to run. The Human Connectome Project is using an Aspera FASP™ server to dramatically boost data transfer speeds. Please install this plugin and allow its use before using any of ConnectomeDBs services, including downloading. (Need help with Aspera install ...
The connectome is extremely complex and not yet well understood. It is the hope of the HCP that by mapping many individuals, they will establish a baseline of normal connectivity and reveal how connectivity differs across individuals displaying psychopathology.. In a recent study published in Nature Neuroscience (Smith et al., 2015), investigators found a significant relationship between the brains default-mode network and personal traits such as IQ, language skills, and life satisfaction. The researchers examined 461 subjects, looking at the correlations between their resting-state functional connectivity and behavioural and demographic measures. They found that the subjects who returned high scores for cognition, memory, education, and income level-as opposed to more "negative" measures such as substance use and aggression-showed higher connectivity in components of their default network. Such connections included the medial frontal and parietal cortex, the temporo-parietal junction, the ...
The function of neural circuits is an emergent property arising from the coordinated activity of large numbers of neurons. To capture this, we propose launching a large-scale, international public effort, the Brain Activity Map Project, aimed at reconstructing the full record of neural activity across complete neural circuits. This technological challenge could prove to be an invaluable step toward understanding fundamental and pathological brain processes.
Video created by Hebrew University of Jerusalem for the course Synapses, Neurons and Brains . Welcome to synapses, neurons and brains! 2000+ courses from schools like Stanford and Yale - no application required. Build career skills in data ...
The Marclab Connectomics Group presents Dr. Eduardo Rosa-Molinar who will deliver a seminar at the Moran Eye Center tomorrow at 4pm on October 8th, 2013 entitled Towards Disentangling Adult Spinal Neural Circuits. His talk will discuss the neurobiology of ultrafast spinal motor networks and imaging networks with field ion beam milling connectomics. What does this have to do with vision? […]. ...
Check out this just published paper by Micah Allen and Gary Williams in the open access journal Frontiers in Psychology. Consciousness is typically construed as being explainable purely in terms of either private, raw feels or higher-order, reflective representations. In contrast to this false dichotomy, we propose a new view of consciousness as an interactive,…
Brain connectivity estimators represent patterns of links in the brain. Connectivity can be considered at different levels of the brains organisation: from neurons, to neural assemblies and brain structures. Brain connectivity involves different concepts such as: neuroanatomical or structural connectivity (pattern of anatomical links), functional connectivity (usually understood as statistical dependencies) and effective connectivity (referring to causal interactions). Neuroanatomical connectivity is inherently difficult to define given the fact that at the microscopic scale of neurons, new synaptic connections or elimination of existing ones are formed dynamically and are largely dependent on the function executed, but may be considered as pathways extending over regions of the brain, which are in accordance with general anatomical knowledge. DTI can be used to provide such information. The distinction between functional and effective connectivity is not always sharp; sometimes causal or ...
The biological validation of human fMRI networks has been challenging, not least because there are fundamental questions outstanding about the biological sources of the BOLD signal itself. We cannot yet securely reduce the basic fMRI observation of inter-regional correlation between pairs of functionally connected BOLD time series to a mechanistic explanation in terms of cellular processes, neuronal physiology, neurovascular coupling or anatomical connectivity. This has made it difficult to test (refute or validate) economical models of human fMRI networks by the classical reductionist logic of explanatory mechanistic coupling between cellular processes, at a micro scale, and network topology metrics, at a macro scale (table 2).. Most of the previous evidence for biological validity of human MRI connectomes has therefore rested on analogical rather than reductionist logic. Informative analogies make comparisons between a poorly understood system and a more certainly or completely understood ...
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Memperkenalkan Persona Elegance baru. Yang lebih baik daripada yang anda harapkan - perjalanan dan pengendalian yang lebih baik, keselesaan yang lebih baik, keselamatan yang lebih baik, prestasi yang lebih baik - dan hanya lebih baik
The STNS is a pre-eminent model system for elucidating a cellular-level understanding of neuronal network operation. All of the STG network neurons are readily recorded intracellularly, they are all physiologically identified, their neurotransmitters and many of their membrane properties are known, and the connectomes are long-established. More than a dozen modulatory transmitters have been localized in projection neuron inputs to the STG from the other STNS ganglia, and an even larger number of peptide hormone modulators are identified in this system. When applied individually, many of these substances elicit distinct versions of the gastric mill and/or pyloric rhythm. Activating different identified modulatory neurons, or the same neurons via distinct input pathways, also elicits distinct rhythms. The unrivaled, detailed STG data library of the circuit consequences of neuromodulation provides an outstanding opportunity to address the 3 issues elucidated above ...
... with Harvard Professor Josh Sanes. Harvard University Professor and Director of Harvards Center for Brain Sciences, Josh Sanes, shares why he thinks understanding synaptic connection networks matter and how mapping the retinal connectome will fundamentally change how we think about the human brain.
Keskeisimmät julkaisut:. Joutsa J*, Shih LC*, Fox MD. Mapping Holmes tremor using the human brain connectome. Ann Neurol 2019. Corp DT*, Joutsa J*, Darby RR et al. Network localisation of cervical dystonia from causal brain lesions. Brain 2019;142(6):1660-74.. Darby RR, Joutsa J, Fox MD. Network localization of heterogeneous neuroimaging findings. Brain 2019;142(1):70-9 ...
Professor, IDG/McGovern Inst for Brain Research, State Key Lab of Cogn Neurosci & Learning, BNU - Cited by 33,075 - Neuroimaging - MRI - Connectome - Network science - Development
So recently I ve been interested in the topic of what a conscious, living creature really is. To quote myself... If Im right, living people are sort of like a computer with the power on. Our brains have an architecture which is the arrangement of our neurons (the connectome.
Circos at the EMBO NGS workshop in Tunis, Sept 15-25. Circos is back for 4rd year at 2014 Bioinformatics and Comparative Genome Analysis course by the Pasteur Institute-Athens, May 7 20 imperatives of information design - BioVis 2012 Another -ome! Circos manages the connectome of 50 brains-NeuroImage 28 Jan Interested in network visualization? Frustrated by hairballs? See my hive plot project. Spunky Scientific Visualization Safely learn about the plague, ebola and marburg at the deadly genomes depot. New England Journal of Medicine animation of E. coli Circos visualization. ...
Circos at the EMBO NGS workshop in Tunis, Sept 15-25. Circos is back for 4rd year at 2014 Bioinformatics and Comparative Genome Analysis course by the Pasteur Institute-Athens, May 7 20 imperatives of information design - BioVis 2012 Another -ome! Circos manages the connectome of 50 brains-NeuroImage 28 Jan Interested in network visualization? Frustrated by hairballs? See my hive plot project. Spunky Scientific Visualization Safely learn about the plague, ebola and marburg at the deadly genomes depot. New England Journal of Medicine animation of E. coli Circos visualization. ...
Development and validation of a pain assessment scale for patients with brain injury and disorders of consciousness. Alterations of the brain´s connectome during recovery from traumatic brain injury: a longitudinal prospective study. Studies in the framework of complex interventions: Dysphagia, patients with COPD. ...
The fight (to the extent that there is a fight), then, is not about whether connectome research is feasible or useful, but about grand challenges and resources. Movshon nailed it when he said people are looking for "gigascience" projects, and that neuroscience has been a "cottage industry." While nobody said it directly, "gigascience" is often about making a sales pitch. People want to be at the forefront of establishing big projects, because the prospect of money is there. Someone made a comment about keeping score, and Movshon said, "The NIH is." Krulwich asked Movshon, "Whats your recruiting pitch? What do you tell the young mavericks to bring them into the field?" (Krulwich occasionally seems to confuse science with the Wild West; also here ...
The HGC is based on what has been discovered about the protein-protein interactions and molecular pathways in which gene products exist and applies a numerical value to how closely connected two genes are. As support of principal the group applied this approach to a disease. They studied the pathogenesis of herpes simplex virus 1 (HSV-1) encephalitis (HSE). Inborn errors of Toll-like receptor 3 (TLR-3) have been shown to be important in HSE pathogenesis, so they developed a TLR-3 specific connectome. The results confirmed what many had previously shown regarding other genes in the molecular pathway which when mutated are also associated with the disease state. In particular, when genetic data from two patients was compared they were both confirmed to have a mutation in TANK-binding kinase which is a biologically close gene and has previously been associated with HSE ...
Of course, all kinds of stuff also happens close to that synapse inside the cell - phosphorylation of all kinds of different proteins, novel expression of other sets of proteins to reduce synapse disassembly, long term changes in scaffolding, possibly recruitment of soluble ribosomes for local mRNA translation, &c&c&c. Changes in the pre-synaptic side is also likely. The connectome is certainly an ambitious undertaking ...
TY - JOUR. T1 - Macroscale variation in resting-state neuronal activity and connectivity assessed by simultaneous calcium imaging, hemodynamic imaging and electrophysiology. AU - Murphy, Matthew. AU - Chan, Kevin C.. AU - Kim, Seong Gi. AU - Vazquez, Alberto L.. PY - 2018/4/1. Y1 - 2018/4/1. N2 - Functional imaging of spontaneous activity continues to play an important role in the field of connectomics. The most common imaging signal used for these experiments is the blood-oxygen-level-dependent (BOLD) functional MRI (fMRI) signal, but how this signal relates to spontaneous neuronal activity remains incompletely understood. Genetically encoded calcium indicators represent a promising tool to study this problem, as they can provide brain-wide measurements of neuronal activity compared to point measurements afforded by electrophysiological recordings. However, the relationship between the calcium signal and neurophysiological parameters at the mesoscopic scale requires further systematic ...
The need to integrate massively increasing amounts of data on the mammalian brain has driven several ambitious neuroscientific database projects that were started during the last decade. Databasing the brains anatomical connectivity as delivered by tracing studies is of particular importance as these data characterize fundamental structural constraints of the complex and poorly understood functional interactions between the components of real neural systems. Previous connectivity databases have been crucial for analysing anatomical brain circuitry in various species and have opened exciting new ways to interpret functional data, both from electrophysiological and from functional imaging studies. The eventual impact and success of connectivity databases, however, will require the resolution of several methodological problems that currently limit their use. These problems comprise four main points: (i) objective representation of coordinate-free, parcellation-based data, (ii) assessment of the ...
To the Editor:. We were pleased to hear that reviewers for our recent submission to eNeuro "Fluorescence-based quantitative synapse analysis for cell-type specific connectomics" found the work potentially suitable for publication. Reviewers recognized that the method could be effective for rapid and large-scale analysis of synaptic connectivity and requested minor clarifications or additional information, which we have now included in our revised manuscript.. Below we respond to specific questions and indicate where revisions have been made in the manuscript. We have added 5 new data panels to Figure 3, and present results from extensive antibody testing for the reviewers here. We hope that this revised version will be judged suitable for publication in eNeuro. Please do not hesitate to contact me if you have any further questions.. Sincerely,. Authors. Response to specific comments. Reviewer 1. 1. "...Could the authors test whether FAPpost could be imaged in vivo with two-photon ...
An unlikely renaissance is occurring in biological imaging, propelled by the ongoing development of serial blockface electron microscopy imaging technologies. Imaging systems based on scanning EM instruments place large-volume automated EM serial imaging within reach of most labs. How best to take advantage of the automation and versatility? Large scale connectomics studies are stunning in their scope and detail. Smaller scale SBFI applications, however, offer academic labs and preclinical researchers opportunities to make new discoveries, measure new outcomes, and detect toxic changes in comparatively unbiased experiments. In this webinar we will discuss todays large volume SBFI technologies, some novel applications that are in current use, and consider how the expanding size of possible specimens is promoting faster throughput imaging.. ...
Dec 22, 2014 Bacterial protein mimetics of neuropeptides at the origin of eating disorders Professor Serguei Fetissov, M.D., Ph.D. Abstract (pdf format, new tab opens) Oct 10, 2014 Development and adult connectomics of cerebral cortex Professor Larry Swanson, Ph. D. Abstract (pdf format, new tab opens) Sep 11, 2014 Direct brain recording in humans and how…
Pape, C, Beier, T, Li, P, Jain, V, Brock, D D and Kreshuk, A (2017). Solving Large Multicut Problems for Connectomics via Domain Decomposition. Bioimage Computing Workshop. ICCV. 1-10 ...
Pape, C, Beier, T, Li, P, Jain, V, Brock, D D and Kreshuk, A (2017). Solving Large Multicut Problems for Connectomics via Domain Decomposition. Bioimage Computing Workshop. ICCV. 1-10 ...
Imagine an exceedingly complex circuit board. Wires often split -- seemingly at random -- and connect in strange and unexpected ways. This is how Princeton University researchers developing a new method for studying brain connectivity see the brain.
Nodes were more prone to disease when they were linked by shorter or stronger functional connections. In other words, the transneuronal spread model best fit disease progression.. While Seeleys group started with the data and asked what models best fit, Raj and colleagues came at it from the opposite direction. They built a biophysical model and fit to it MRI data from healthy, AD, and FTD brains. These scientists propose that toxic proteins diffuse through the brain in a classic mechanism whereby concentration gradients drive their random dispersion. This, they posit, follows brain connectivity networks. Their so-called network diffusion model precisely recapitulated the pattern of atrophy progression of AD and behavioral variant frontotemporal dementia. It might even be able to predict what brain regions will atrophy in the future based on baseline MRI morphometrics, Raj and colleagues write.. How can these new models help researchers? Can they aid in diagnosis or prognosis? The authors claim ...
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A new paper in the open access journal PLoS Biology describes a new way to model the human brain using diffusion spectrum imaging. Since were in the omics age of science, you shouldnt be surprised that this map is dubbed the connectome. The semantics of the connectome is similar to genome, proteome, metabalome, transcriptome --…
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Case #1: The Toll-like receptor 3 (TLR3) gene, discovered in the Casanova lab years earlier, causes the life-threatening brain inflammation herpes simplex virus 1 encephalitis (HSE) in children. TLR3 controls innate immunity, impairing a specific interferon.. The human gene connectome produced results both expected and not. "We took 2 patients who had HSE and had very recently been discovered to have a disease-causing gene called TBK1," Dr. Itan told me. "So we thought if we take gene variations and run them by their distance to TLR3, would TBK1 show up? In both patients, it showed up first, purely based on this computational prediction." The TLR3-specific connectome revealed two novel TLR3 pathway genes prior to their experimental validation - EFGR and SRC.. In a second test case, a mutation in a collagen gene that causes a form of Ehlers-Danlos syndrome pulled out 26 other genes associated with the Ehlers-Danlos syndrome and its genetic pathway.. Finding new genes behind what was thought to be ...
The goal of our research is to understand use-driven brain network plasticity in children with brain injury, in order to develop novel neurorehabilitative treatments. To this end, we are studying childrens brains using resting state functional connectivity MRI (rs-fcMRI) and task-based functional MRI (fMRI). We are focused on pushing structural and functional MRI acquisition and analysis methodology to the level of individual patients. In order to create and annotate the connectomes of individuals (Individuomes) we must first improve the signal-to-noise, spatial resolution and replicability of fMRI and rs-fcMRI data. High-fidelity Individuomes should help accelerate fMRI-based diagnostics and neurofeedback rehabilitation therapy.. One of the main complications for rs-fcMRI and fMRI in children is excessive head movement, which introduces systematic distortions. Post-hoc data censoring methods can remove movement artifact from rs-fcMRI data, but in children post-hoc censoring leads to ...
Methodology to annotate the multiple origins of axonal projections in dense electron microscopy data of mammalian nervous tissue without the need of chemical label conversion is reported.
This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by J Scott Lauritzen, Noah T. Nelson, Crystal L. Sigulinsky, Nathan Sherbotie, John Hoang, Rebecca L. Pfeiffer, James R. Anderson, Carl B. Watt, myself and Robert E. Marc.. Purpose: Despite large-scale efforts aimed at mapping the mammalian nervous system, the entire synaptic cohort of a single mammalian neuron of any class has never been mapped. To this end we reconstructed all chemical and electrical synaptic partners of a single ON cone bipolar cell in the inner plexiform layer (IPL) of the rabbit retina. We then searched all members of the same cell class for repeating network motifs and explored postsynaptic cell sampling topologies from this bipolar cell.. Methods: Cells in retinal connectome 1 (RC1) were annotated with Viking viewer, and explored via graph visualization of connectivity and 3D rendering (Anderson et al., 2011 J Microscopy). Small molecule ...
Biologically-reliable computer simulation of the nervous system is the cross-disciplinary area of research which is quite novel and mostly related to neurobiology, neurocybernetics and artificial intelligence. The main idea is to study the mechanisms of brain functioning by means of investigation of its work in details at neuronal and subneuronal level (membranes, neurites, neuromediators, ion channels etc.) and implementation of this data and knowledge within a dynamic model. Its quite obvious to start from the most simple organism to test the overall conception, and continue with more complex ones in case of success. For this purpose C. elegans nematode is currently the only animal with almost known neural network architecture (connectome). Moreover, its structure, including neurons positions, morphological features and interneuron connections is invariant for all animals of one sex. Relative simplicity but still quite complex behavioral patterns, as well as abilities for learning and memory ...
Whitaker, K. J.; Vértes, P. E.; Romero-Garcia, R.; Vása, F.; Moutoussis, M.; Prahub, G.; Weiskopf, N.; Callaghan, M. F.; Wagstyl, K.; Rittmann, T. et al.; Tait, R.; Ooi, C.; Suckling, J.; Inkster, B.; Fonagy, P.; Dolan, R. J.; Jones, P. B.; Goodyer, I. M.; the NSPN Consortium; Bullmore, E. T.: Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome. Proceedings of the National Academy of Sciences of the United States of America 113 (32), pp. 9105 - 9110 (2016 ...
Mechling AE, Arefin T, Lee H-L, Bienert T, Reisert M, Ben Hamida S, Darcq E, Ehrlich A, Gaveriaux-Ruff C, Parent MJ et al.. 2016. Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome.. Proc Natl Acad Sci U S A. 113(41):11603-11608. ...
Mechling AE, Arefin T, Lee H-L, Bienert T, Reisert M, Ben Hamida S, Darcq E, Ehrlich A, Gaveriaux-Ruff C, Parent MJ et al.. 2016. Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome.. Proc Natl Acad Sci U S A. 113(41):11603-11608. ...
杭州师范大学静息态功能磁共振影像免费培训(第四期). 2019年04月14日(周日) 13:00-17:00. 主办单位:. 杭州师范大学心理科学研究院. 杭州师范大学附属医院认知与脑疾病研究中心. 浙江省认知障碍评估技术研究重点实验室. 承办单位:. 杭州拾睿科技有限公司. 为了加强社会服务,杭州师范大学拟针对静息态功能磁共振影像研究者开展免费培训服务,暂定每月一次。. 第四期讲座的题目为Resting-state fMRI and "state" fMRI Design: data analysis and application,时间定于2019年04月14日13:00-17:00。本次讲座主要面向心理学领域从事静息态功能磁共振影像或拟采用state任务fMRI设计的研究者,通过QQ网络的方式进行。感兴趣的朋友请填写附件中的报名表格,并发送邮件至贾熙泽([email protected])。. 讲者及简介:. 1. 题目:Resting-state fMRI and "state" fMRI ...
Connectomics and Cortical Transistors Margie shares; German scientists have recently discovered a precise nerve cell connectivity pattern (nerve cell circuits) in part of the cerebral cortex, which is responsible for orienting us in space. These grid cells provide a very particular representation of the space around the individual human and are known to be active when we are located at highly ordered grid-like locations in a room or a large space.. Read more within the following articles and research;. ...
Alison Calder, raised and partly educated in Saskatoon, is now a professor of literature at the University of Manitoba and a poet and critic with numerous publications to her credit. In the fascinating Connectomics she writes of neural pathways, where various emotions and memories are stored in the brain, and how we go about mapping that still mysterious organ in our skulls.. Whats most fascinating about this small collection is not the science itself, which has its appeal, but the way in which Calder toys with the idea of how to describe a place so important to us but to which so very few of us go, or even care to know. The brain, to most people, is just the brain until something goes wrong with it, but right now thousands of scientists are mapping it and trying to understand its functions. In Infinity Calder opens, "After we exhausted wonder/ we shut down the computers, turned off/ the lights. Everything/ was known," and ends, "We grew our knowledge right up to the end./ When we got to the ...
Focused Ion Beam Scanning Electron Microscopy (FIB-SEM) can automatically generate 3D images with superior z-axis resolution, yielding data that needs minimal image registration and related post-processing. Obstacles blocking wider adoption of FIB-SEM include slow imaging speed and lack of long-term system stability, which caps the maximum possible acquisition volume. Here we present techniques that accelerate image acquisition while greatly improving FIB-SEM reliability, allowing the system to operate for months and generating continuously imaged volumes , 10(6) µm(3). These volumes are large enough for connectomics, where the excellent z resolution can help in tracing of small neuronal processes and accelerate the tedious and time-consuming human proofreading effort. Even higher resolution can be achieved on smaller volumes. We present example data sets from mammalian neural tissue, Drosophila brain, and Chlamydomonas reinhardtii to illustrate the power of this novel high-resolution technique ...
Genomics was driven by increasing technology and was addictive, because, it is not too cynical to say, it was thought-free, meat-grinder, factory science. It was lucrative, did indeed teach us a lot about what genes and genomes do, and found a modest number of important causal genes. Its success, at least in the fashion and funding senses, understandably spawned other hypothesis-free blind technological approaches, cashing in on the cachet of the omics word and its rejection of the need for actual prior hypotheses to design studies: nutriomics, connectomics, metabolomics, microbiomics, immunomics, epigenomics, and more. How much of this was because the same people who were promising us that successful disease prediction with genetics was right around the corner realized that this just wasnt true, and needed to figure out ways to keep their labs running we cant say, but we certainly are a fad-following, money-following research culture and we know this is part of the story. To be fair, when ...
Interest in brain connectivity inference has become ubiquitous and is now increasingly adopted in experimental investigations of clinical, behavioral, and experimental neurosciences. Methods in Brain
Provides the latest translational research discoveries in brain mapping, modeling, novel research techniques, and more in the rapidly advancing field of connectivity research at the systems and network levels.
Principal Investigator:Matsumoto Riki, Project Period (FY):2014-04-01 - 2016-03-31, Research Category:Grant-in-Aid for Challenging Exploratory Research, Research Field:Brain biometrics
Connectome[edit]. Drosophila is one of the few animals (C. elegans being another) where detailed neural circuits (a connectome ... Detailed circuit-level connectomes exist for the lamina[83][84] and a medulla[85] column, both in the visual system of the ... In 2020, a dense connectome of half the central brain of Drosophila was released,[89] along with a web site that allows queries ... A high-level connectome, at the level of brain compartments and interconnecting tracts of neurons, exists for the full fly ...
"Sequencing the Connectome: Will DNA Bar Codes and a Sneaky Virus Change the Way Scientists Map the Brain?". Scientific American ... Zador AM, Dubnau J, Oyibo HK, Zhan H, Cao G, Peikon ID (2012). "Sequencing the Connectome". PLOS Biology. doi:10.1371/journal. ... More recently, he proposed a new approach to connectome mapping using the methods of molecular biology, which may dramatically ...
Connectome Connectomics Human Connectome Project Brain mapping Tractography Chord diagram Irimia, Andrei; Chambers, M.C.; ... "Human Connectome Project". NIH. "Hard Cell". The Economist. 9 March 2013. Retrieved 11 March 2013. [circos.ca circos.ca] Check ... Most other representations of the connectome use 3 dimensions, and therefore require an interactive graphical user interface. ... "Imaging human connectomes at the macroscale". Nature Methods. 10 (6): 524-39. doi:10.1038/nmeth.2482. PMC 4096321 . PMID ...
Leergaard, Trygve (2011). Mapping the Connectome. Frontiers. p. 135. ISBN 2889191079. Office of the Provost. "Center for Social ...
... "functional connectome", as well as new technologies that will have to be developed in the course of the project. They indicated ... "Sequencing the Connectome". PLoS Biology. 10 (10): e1001411. doi:10.1371/journal.pbio.1001411. PMC 3479097 . PMID 23109909. ... Therapeutic Scientific Summit Human Connectome Project List of animals by number of neurons List of neuroscience databases ...
"The AII amacrine cell connectome: A dense network hub". Frontiers in Neural Circuits. 8: 104. doi:10.3389/fncir.2014.00104 ... "The AII amacrine cell connectome: A dense network hub". Frontiers in Neural Circuits. 8: 104. doi:10.3389/fncir.2014.00104 ...
Kopell, Nancy J.; Gritton, Howard J.; Whittington, Miles A.; Kramer, Mark A. (2014-09-17). "Beyond the connectome: the dynome ... DeFelipe, Javier (2010-11-26). "From the Connectome to the Synaptome: An Epic Love Story". Science. 330 (6008): 1198-1201. doi: ... Membranome Metagenome Moleculome Glycome Ionome Lipidome Metabolome Volatilome Metallome Proteome Phenome Physiome Connectome ...
Text is available under the Creative Commons Attribution/Share-Alike License and the GFDL; additional terms may apply. See Terms of Use for details ...
See also: Connectome. Apart from intrinsic properties of neurons, biological neural network properties are also an important ... Neural oscillation can also arise from interactions between different brain areas coupled through the structural connectome. ...
Several initiatives such as the Human Connectome Project try to build a connectome or a neural connectivity map that will shed ... Melodic for ICA), CONN, C-PAC, and Connectome Computation System (CCS). There are many methods of both acquiring and processing ... link) Van Essen, D. C.; Ugurbil, K. (2012). "The future of the human connectome. [Review]". NeuroImage. 62 (2): 1299-1310. doi: ... "Consistency of network modules in resting-state FMRI connectome data". PLOS ONE. 7 (8): e44428. doi:10.1371/journal.pone. ...
Connectome Diffusion MRI Connectogram Basser, P.; et al. (2000). "In Vivo Fiber Tractography Using DT-MRI Data". Magnetic ... 2016). "Tractography-based connectomes are dominated by false-positive connections". bioRxiv 084137 . PhD thesis on Diffusion ...
It is then possible to trace each motor axon and its synaptic contacts to construct a complete connectome of the muscle. More ... PMC 3226220 . Lichtman, Jeff; Jean Livet; Joshua Sanes (June 2008). "A technicolour approach to the connectome". Nature Reviews ...
... to be the first work in the emerging field of connectomes. More recently his research uses: " two collaborative but distinct ...
Apr 2014). "A mesoscale connectome of the mouse brain". Nature. 508 (7495): 207-14. doi:10.1038/nature13186. PMC 5102064 . PMID ... Apr 2014). "A mesoscale connectome of the mouse brain". Nature. 508 (7495): 207-14. doi:10.1038/nature13186. PMC 5102064 . PMID ...
neuroanatomy stereotaxy Stereotaxic atlas connectome "NeuroMaps Viewer". Neuromaps.braininfo.org:8180. Retrieved 2016-01-30. " ...
"Parameterizable consensus connectomes from the Human Connectome Project: the Budapest Reference Connectome Server v3.0". ... The connectome, or the braingraph, can be constructed from diffusion MRI data: the vertices of the graph correspond to ... The Budapest Reference Connectome Server depicts the cerebral connections of n=418 subjects with a frequency-parameter k: For ... The Consensus Connectome Dynamics (CCD) is a remarkable phenomenon that was discovered by continuously decreasing the minimum ...
"Parameterizable consensus connectomes from the Human Connectome Project: the Budapest Reference Connectome Server v3.0". ... The connectome can be constructed from diffusion MRI data: the vertices of the graph correspond to anatomically labelled gray ... The Consensus Connectome Dynamics (CCD) is a remarkable phenomenon that was discovered by continuously decreasing the minimum ... Kerepesi, Csaba; Szalkai, Balazs; Varga, Balint; Grolmusz, Vince (2016). "How to Direct the Edges of the Connectomes: Dynamics ...
Picchioni, Dante; Duyn, Jeff H.; Horovitz, Silvina G. "Sleep and the functional connectome". NeuroImage. 80: 387-396. doi: ... "The structural-functional connectome and the default mode network of the human brain". NeuroImage. 102: 142-151. doi:10.1016/j. ...
The connectome scanner generates a map of the axons in white matter, connections of the brain, by measuring the nearby movement ... Scott, Tom; Jones, Derek (24 July 2017). Connectome Scanning: Looking at the Brain's Wiring (video). YouTube. Retrieved 24 July ... and the first connectome scanner outside the United States, a Siemens 3 Tesla Connectom system. The centre aims to investigate ...
352 p Archived 2016-01-31 at the Wayback Machine.. (ISBN 978-5-699-81143-4) Seung S. Connectome. 2015. - 440 p. (ISBN 978-5- ...
Leergaard, Trygve B.; Hilgetag, Claus C.; Sporns, Olaf (2012-05-01). "Mapping the Connectome: Multi-Level Analysis of Brain ... Optogenetic activation has been combined with functional magnetic resonance imaging (ofMRI) to elucidate the connectome, a ...
Marc, R. E.; Anderson, J. R.; Jones, B. W.; Sigulinsky, C. L.; Lauritzen, J. S. (2014). "The AII amacrine cell connectome: A ... Marc, R. E.; Anderson, J. R.; Jones, B. W.; Sigulinsky, C. L.; Lauritzen, J. S. (2014). "The AII amacrine cell connectome: A ...
Connectomics: The study of the connectome, the totality of the neural connections in the brain. ...
"Sex differences in the structural connectome of the human brain". PNAS. National Academy of Sciences. 111 (2): 823-828. doi: ...
"Neuronal connectome of a sensory-motor circuit for visual navigation". eLife. 3. doi:10.7554/eLife.02730. Berger, Noel A.; Eeg ...
AS Seeds Featured Blogger of the week, I have written a short article about the Human Connectome Project, in response to a ... Part of the problem is that there is no such thing as "the connectome". The STG that Bjorn mentions is a perfect example. ... Also, I wonder what you make of these publications on connectomes:. * Hagmann P, Kurant M, Gigandet X, Thiran P, Wedeen VJ, ... Part of the problem is that there is no such thing as "the connectome". The STG that Bjorn mentions is a perfect example. ...
The U.S. governments Human Connectome Project moves into its second phase-and its brain scans are being used to predict ... Advances in medical imaging allow the Human Connectome Project to map neural connections ...
The connectome can be studied as a network by means of network science and graph theory. In case of a micro-scale connectome, ... The term "connectome" was more recently popularized by Sebastian Seungs "I am my Connectome" speech given at the 2010 TED ... The Budapest Reference Connectome has led the researchers to the discovery of the Consensus Connectome Dynamics of the human ... I am my connectome EyeWire, a citizen science game to map the retinal connectome MITK Diffusion: Free software for the ...
The Drosophila connectome, once completed, will be a complete list of the roughly 135,000 neurons in the brain of the fruit fly ... Detailed circuit-level connectomes exist for the lamina and a medulla column, both in the visual system of the fruit fly. ... A high-level connectome, at the level of brain compartments and interconnecting tracts of neurons, exists for the full fly ... On the other hand, one of the main uses of a connectome is to relate structure and behavior, so an animal with a large ...
... a human beings connectome could be simulated and uploaded onto a computer". Daniel Levitin praised Connectome as "the best ... Connectome, p. 169 Seung reviews the history of mapping the Caenorhabditis elegans connectome by Sydney Brenner and colleagues ... Connectome: How the Brains Wiring Makes Us Who We Are (2012) is a book by Sebastian Seung. It introduces basic concepts in ... You are your connectome." Seung introduces the 19th-century idea of phrenology and its modern-day counterpart, which he calls " ...
"Parameterizable consensus connectomes from the Human Connectome Project: the Budapest Reference Connectome Server v3.0". ... The Budapest Reference Connectome has led the researchers to the discovery of the Consensus Connectome Dynamics of the human ... It has been prepared from diffusion MRI datasets of the Human Connectome Project into a reference connectome (or brain graph), ... There is an option for viewing and comparing the female or male reference connectomes. The connectomes of women contain ...
Synaptic relationships among amacrine and rod bipolar cells in the Viking connectome viewer. (A) Slice z277: overlay of glycine ... AII cells in connectome RC1. (A) Slice z001 with 5 channel molecular overlay (see Anderson et al., ), 5 rendered AII cells (410 ... Synaptic patterns of AII cell lobules in the Viking connectome viewer. (A) Slice z71 showing annotation overlays for cells ( ... The AII amacrine cell connectome: a dense network hub.. Marc RE1, Anderson JR1, Jones BW1, Sigulinsky CL1, Lauritzen JS1. ...
Sporns, O., Tononi, G., & Kötter, R. (2005). The human connectome: A structural description of the human brain. PLoS ...
NIH Human Connectome Project RFA * Home page of the Human Connectome Project consortium centered at Washington University and ... The connectome at the large scale. There are several established empirical approaches that allow the construction of connectome ... The future of the connectome. While the full connectome at cellular resolution seems presently out of reach, at least for the ... The connectome is the complete description of the structural connectivity (the physical wiring) of an organisms nervous system ...
Mapping The Structural Connectome in Autism. March 1st, 2013 John Hewitt Neurology, News, Radiology ... Study in NeuroImage: The structural connectome of the human brain in agenesis of the corpus callosum ...
Mathematics of the Human Brain Connectome Mathematics of the Human Brain Connectome ... The human brain connectome is an ambitious project to provide a complete map of neural connectivity and a recent source of ... the human connectome is a result of a similar union. The technology in question is that of diffusion magnetic resonance imaging ...
The brains connectome - from branch to branch. Max Planck scientists develop new analytical tools for the fast and accurate ... the connectome - and to reconstruct it in a three-dimensional map. Since no computer is powerful enough yet for the task, ...
We call this neuronal ensemble the "gut connectome" and summarize the work from a food sensory perspective. ...
The C. elegans connectome should be discussed more completely, as it is the only connectome that has been found so far. ... The "connectome" article should be rewritten to truly focus on connections. Right now the only method for finding connectomes ... Id like to call for a more careful definition of the term "connectome." For this we need a more precise definition of ... Heres another way to think about it: The connectome follows the tradition of Brenner...though he hates the word :) The ...
Q: Do you foresee the efforts to map the human connectome shedding light any time soon on the tendency of Alzheimers, ... "Network Epicenters" in Healthy Connectome Predict Dementia. Tuesday, April 10, 2012 at 12:00 AM US EDT. ... Could scientists even foretell where and when pathology will surface just by looking at the connectome of a healthy person? ...
C. elegans connectome. The filled nodes are the previously-known neurons involved in the worms response to gentle touch. ... Network control principles predict neuron function in the Caenorhabditis elegans connectome.. Yan G1,2, Vértes PE3, Towlson EK1 ... c) The C. elegans connectome used in our study, consisting of 279 neurons (the 282 nonpharyngeal neurons, excluding CANL/R and ... Here we fill this gap by applying a control framework to the connectome of the nematode Caenorhabditis elegans, allowing us to ...
Furthermore, the functional connectome is thought to be more flexible, while the anatomical connectome is relatively stable [25 ... The anatomical connectome exhibited typical features of small-word topology no matter pre- or post-ECT. However, no significant ... Reorganization of Anatomical Connectome following Electroconvulsive Therapy in Major Depressive Disorder. Jinkun Zeng. ,1 ... O. Sporns, G. Tononi, and R. Kötter, "The human connectome: a structural description of the human brain," PLoS Computational ...
A probabilistic atlas of human brainstem pathways based on connectome imaging data.. Tang Y1, Sun W2, Toga AW2, Ringman JM3, ... With the release of high-resolution data from the Human Connectome Project (HCP), there is increasing interest in mapping human ... Finally, we leveraged our novel connectome modeling techniques including high order fiber orientation distribution (FOD) ...
The Human Connectome Project intends to map the neural pathways that underlie human brain function. This week NIH has awarded ... Human Connectome Project Starts Mapping the Human Brains Connections. September 20th, 2010 Wouter Stomp Neurology, News ... The Human Connectome Project intends to map the neural pathways that underlie human brain function. This week NIH has awarded ... Processed data from the project will become web accessible via a customized Connectome Database Neuroinformatics Platform.. ...
Connectome-wide, genome-wide scan discovers SPON1. Neda Jahanshad, Priya Rajagopalan, Xue Hua, Derrek P. Hibar, Talia M. Nir, ... Connectome-wide, genome-wide scan discovers SPON1. Neda Jahanshad, Priya Rajagopalan, Xue Hua, Derrek P. Hibar, Talia M. Nir, ... Connectome-wide, genome-wide screening offers substantial promise to discover genes affecting brain connectivity and risk for ... Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity. Neda Jahanshad, Priya ...
The mammalian AII retinal amacrine cell is a narrow-field, multistratified glycinergic neuron best known for its role in collecting scotopic signals from rod bipolar cells and distributing them to ON and OFF cone pathways in a crossover network via a
Creator & director : email [email protected] Cryonics-for-Connectomes or Connectome-Cryonics are equivalent terms for ... in uploading by definition but rather reversible suspended animation which does require proof of survival of connectomes ...
Common Dimensional Reward Deficits Across Mood and Psychotic Disorders: A Connectome-Wide Association Study.. Sharma A1, Wolf ... Connectome-wide analysis using multivariate distance-based matrix regression (MDMR). Template-space functional time series were ... Here, the authors explore the entire functional connectome in relation to reward responsivity across a population of adults ... Connectome-Wide Analysis Reveals Common Dimensional Reward Deficits Across Mood and Psychotic Disorders ...
Towlson EK, Vértes PE, Ahnert SE et al (2013) The rich club of the C. elegans neuronal connectome. J Neurosci 33:6380-6387. doi ... 10), we do not expect them to obscure the systematic properties of the global cortical connectome that we have identified. We ... While additional parameters remain to be tested for their impact on the cortical connectome, our results suggest that some of ... De Reus MA, van den Heuvel MP (2013) Rich club organization and intermodule communication in the cat connectome. J Neurosci 33: ...
Simulating a Human Connectome: Spaun. Worms are one thing, people another. And the amount of time it took Bumbarger to map just ... As Sebastian Seung, PhD, author of Connectome: How the Brains Wiring Makes Us Who We Are, notes in a widely watched TED talk ( ... Building a Connectome at the Microscale. Meanwhile, Mitras Cold Spring colleague Anthony Zador, MD, PhD, co-founder of the ... Building a Connectome by Taking the Middle Road. In 1993, Francis Crick coauthored a Nature article ("Backwardness of Human ...
  • The objective of this study is to evaluate machine learning algorithms aimed at predicting surgical treatment outcomes in groups of patients with temporal lobe epilepsy (TLE) using only the structural brain connectome. (nih.gov)
  • Specifically, the brain connectome is reconstructed using white matter fiber tracts from presurgical diffusion tensor imaging. (nih.gov)
  • In summary, using the unprecedented information provided in the brain connectome, machine learning algorithms may uncover pathological changes in brain network organization and improve outcome forecasting in the context of epilepsy. (nih.gov)
  • Connectome: How the Brain's Wiring Makes Us Who We Are (2012) is a book by Sebastian Seung. (wikipedia.org)
  • The connectome, Seung explained, is the totality of the connections among the human brain's 100 billion neurons . (cleveland.com)
  • Connectome" begins with a history lesson, recapping the 19th-century obsession among phrenologists to link the brain's size to intelligence, and moving into the 20th-century advances in deciphering neuron-to-neuron cross talk. (cleveland.com)
  • Connectome Scanning: Looking at the Brain's Wiring (video). (wikipedia.org)
  • Connectome: How the Brain's Wiring Makes Us Who We Are. (wikipedia.org)
  • Seung has been able to popularize the Connectome Theory through his 2010 Ted Conference speech titled "I Am My Connectome" as well as through his book Connectome: How the Brain's Wiring Makes Us Who We Are released in 2012. (wikipedia.org)
  • He authored a book, Connectome: How the Brain's Wiring Makes Us Who We Are, released in February 2012. (wikipedia.org)
  • Graph-tool can be used to work with very large graphs in a variety of contexts, including simulation of cellular tissue, data mining, analysis of social networks, analysis of P2P systems, large-scale modeling of agent-based systems, study of academic Genealogy trees, theoretical assessment and modeling of network clustering, large-scale call graph analysis, and analysis of the brain's Connectome. (wikipedia.org)
  • Sebastian Seung, Connectome, p. 169 Seung reviews the history of mapping the Caenorhabditis elegans connectome by Sydney Brenner and colleagues, published in 1986. (wikipedia.org)
  • This is why Seung describes the effort to map the human connectome as "one of the greatest technological challenges of all time," and asserts that it will "take generations to succeed. (biomedicalcomputationreview.org)
  • Five years later, Seung elaborates in "Connectome," his bracing, mind-expanding report from neuroscience's razor edge. (cleveland.com)
  • Accessible, witty, imminently logical and at times poetic, "Connectome" establishes Seung as an important new researcher, philosopher and popularizer of brain science. (cleveland.com)
  • Since the connectome defines the pathways along which neural activity can flow, we might regard it as the streambed of consciousness," Seung writes. (cleveland.com)
  • In his 2010 Ted Conference speech, Seung hypothesizes that the essence of a human being is its connectome. (wikipedia.org)
  • Seung proposes that a connectome is like a riverbed. (wikipedia.org)
  • Despite such complex and variable structure-function mappings, the connectome is an indispensable basis for the mechanistic interpretation of dynamic brain data, from single-cell recordings to functional neuroimaging . (scholarpedia.org)
  • A probabilistic atlas of human brainstem pathways based on connectome imaging data. (nih.gov)
  • Applications are sought that will apply the Human Connectome data collection protocol to disease/disorder cohorts of interest to the Institutes and Centers that are participating in this FOA. (nih.gov)
  • The Connectome Coordination Facility (CCF) houses and distributes public research data for a series of studies that focus on the connections within the human brain. (humanconnectome.org)
  • We have released and maintain a set of open-source Connectome software that supports browsing, download, exploration, visualization and analysis of HCP data. (humanconnectome.org)
  • The participant data from our research into the Human Connectome that is stored in our XNAT server is de-identified, and contains no personal health information (PHI). (humanconnectome.org)
  • The memory required to explicitly store dense connectomes in main memory can render their analysis infeasible, especially when considering high-resolution data or analyses across multiple subjects or conditions. (frontiersin.org)
  • In doing so, memory required for a dense connectome is reduced to the amount needed to store the underlying time series data. (frontiersin.org)
  • Since the first release of HCP data became available to purchase on hard drive in March 2013, the Connectome team has shipped almost 8 Petabytes of data on more than 1,100 hard drives. (humanconnectome.org)
  • Published today in Nature Neuroscience is a primer on the Human Connectome Project's style of data collection, processing, analysis, and open-access distribution. (humanconnectome.org)
  • Aim 4 will be to deposit images and behavioral data into the CCF and host the Baby Connectome Website. (humanconnectome.org)
  • Data will be made accessible via a customized Connectome Database Neuroinformatics Platform. (humanconnectome.org)
  • Comparing the connectomes and genetic data of genetically identical twins with fraternal twins will reveal the relative contributions of genes and environment in shaping brain circuitry and pinpoint relevant genetic variation. (humanconnectome.org)
  • Topics will include comprehensive coverage of acquisition protocols, Connectome software tools, and Connectome data. (humanconnectome.org)
  • At the booth, we give live, hands-on demonstrations of our Connectome software tools and teach users about accessing Connectome data. (humanconnectome.org)
  • In this work, we propose a simple yet effective solution to the problem of connectome inference in calcium imaging data. (arxiv.org)
  • With at our disposal a steadily growing volume of publicly available neuroimaging data, it is however possible to improve the estimation procedures involved in connectome mapping. (springer.com)
  • Compared to existing state-of-the-art methods that use VBM data, the proposed two-stage connectome-based prediction framework is a suitable alternative with comparable prediction performance. (nih.gov)
  • This suggests that gyrification-based connectomes could be a means to generate systems-based measures from anatomic data to advance the prediction of transition to psychosis in clinical high-risk (CHR) individuals. (psychiatryadvisor.com)
  • Church is known for his professional contributions in the sequencing of genomes and interpreting such data, in synthetic biology and genome engineering, and in an emerging area of neuroscience that proposes to map brain activity and establish a "functional connectome. (wikipedia.org)
  • Our comprehensive connectome reveals complex circuits that include candidate anatomical substrates for both HR and BL types of motion detectors. (janelia.org)
  • The tools used to build this connectome are revolutionizing neuroanatomy and have been made freely available to all scientists worldwide. (wikipedia.org)
  • Here we fill this gap by applying a control framework to the connectome of the nematode Caenorhabditis elegans, allowing us to predict the involvement of each C. elegans neuron in locomotor behaviours. (nih.gov)
  • Duke researchers are currently building an online portal for scientists around the world to access the connectome to guide their own research into mouse neurocircuitry. (healthcanal.com)
  • Third, by using topologic measures of the gyrification connectome, the researchers were able to predict the future outcome of a transition to psychosis with 81.34% balanced accuracy. (psychiatryadvisor.com)
  • To accomplish this, the Marc Lab built specialized connectome viewing software to allow researchers to see into large images and trace their connections. (wikipedia.org)
  • The connections between the cells are critical for brain function, so neuroscientists are keen to understand the structure of these circuits - the connectome - and to reconstruct it in a three-dimensional map. (mpg.de)
  • We reconstructed a comprehensive connectome of the circuits of Drosophila's motion-sensing T4 cells using a novel EM technique. (janelia.org)
  • Over a long period of time, in the same way that the water of the stream slowly shapes the bed, neural activity changes the connectome. (cleveland.com)
  • The connectome is the riverbed which both guides the neural activity while also being shaped by the water over time. (wikipedia.org)
  • Others have criticized attempts towards a microscale connectome, arguing that we don't have enough knowledge about where to look for insights, or that it cannot be completed within a realistic time frame. (wikipedia.org)