A comprehensive map of the physical interconnections of an organism's neural networks. This modular organization of neuronal architecture is believed to underlie disease mechanisms and the biological development of the CENTRAL NERVOUS SYSTEM.
Birth defect that results in a partial or complete absence of the CORPUS CALLOSUM. It may be isolated or a part of a syndrome (e.g., AICARDI'S SYNDROME; ACROCALLOSAL SYNDROME; ANDERMANN SYNDROME; and HOLOPROSENCEPHALY). Clinical manifestations include neuromotor skill impairment and INTELLECTUAL DISABILITY of variable severity.
A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.
Neural tracts connecting one part of the nervous system with another.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.

Parcellations and hemispheric asymmetries of human cerebral cortex analyzed on surface-based atlases. (1/116)

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Cortical parcellations of the macaque monkey analyzed on surface-based atlases. (2/116)

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The anatomical distance of functional connections predicts brain network topology in health and schizophrenia. (3/116)

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Functional organization of the neural language system: dorsal and ventral pathways are critical for syntax. (4/116)

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Identifying behavioral circuits in Drosophila melanogaster: moving targets in a flying insect. (5/116)

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Functional connectivity measured with magnetoencephalography identifies persons with HIV disease. (6/116)

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The Human Connectome Project: a data acquisition perspective. (7/116)

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Building retinal connectomes. (8/116)

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TY - JOUR. T1 - Connectome organization is related to longitudinal changes in general functioning, symptoms and IQ in chronic schizophrenia. AU - Collin, G.. AU - de Nijs, J.. AU - Hulshoff Pol, H. E.. AU - Cahn, W.. AU - van den Heuvel, M. P.. PY - 2016/6/1. Y1 - 2016/6/1. N2 - Emerging evidence suggests schizophrenia to involve widespread alterations in the macroscale wiring architecture of the human connectome. Recent findings of attenuated connectome alterations in unaffected siblings of schizophrenia patients suggest that altered connectome organization may relate to the vulnerability to develop the disorder, but whether it relates to progression of illness after disease onset is currently unknown. Here, we examined the interaction between connectome structure and longitudinal changes in general functioning, clinical symptoms and IQ in the 3 years following MRI assessment in a group of chronically ill schizophrenia patients. Effects in patients were compared to associations between ...
The functioning of the human brain relies on the interplay and integration of numerous individual units within a complex network. To identify network configurations characteristic of specific cognitive tasks or mental illnesses, functional connectomes can be constructed based on the assessment of synchronous fMRI activity at separate brain sites, and then analyzed using graph-theoretical concepts. In most previous studies, relatively coarse parcellations of the brain were used to define regions as graphical nodes. Such parcellated connectomes are highly dependent on parcellation quality because regional and functional boundaries need to be relatively consistent for the results to be interpretable. In contrast, dense connectomes are not subject to this limitation, since the parcellation inherent to the data is used to define graphical nodes, also allowing for a more detailed spatial mapping of connectivity patterns. However, dense connectomes are associated with considerable computational demands in
TY - JOUR. T1 - Functional connectome of the striatal medium spiny neuron. AU - Chuhma, Nao. AU - Tanaka, Kenji F.. AU - Hen, René. AU - Rayport, Stephen. PY - 2011/1/26. Y1 - 2011/1/26. N2 - Dopamine system disorders ranging from movement disorders to addiction and schizophrenia involve striatal medium spiny neurons (MSNs), yet their functional connectivity has been difficult to determine comprehensively. We generated a mouse with conditional channelrhodopsin-2 expression restricted to medium spiny neurons and assessed the specificity and strength of their intrinsic connections in the striatum and their projections to the globus pallidus and the substantia nigra. In the striatum, medium spiny neurons connected with other MSNs and tonically active cholinergic interneurons, but not with fast-spiking GABA interneurons. In the globus pallidus, medium spiny neurons connected strongly with one class of electrophysiologically identified neurons, but weakly with the other. In the substantia nigra, ...
The member universities of the Human Connectome Project take privacy very seriously, whether dealing with participant data or the data of those visiting this website. The participant data from our research into the Human Connectome that is stored in our XNAT server is de-identified, and contains no personal health information (PHI). Our website collects names and email addresses via our contact form. This information is used solely by the administrators and members of the HCP website and is not shared, traded or sold to third parties under any circumstances. Our website may also collect non-personal data about site visits, sessions, and IP addresses. This information is only used for diagnostic or debugging purposes, to help us optimize our websites performance, and is not shared externally. This is a standard practice for most websites, and this data is never linked with personally identifiable information. This website contains links to other websites whose content we think is relevant. ...
The member universities of the Human Connectome Project take privacy very seriously, whether dealing with participant data or the data of those visiting this website. The participant data from our research into the Human Connectome that is stored in our XNAT server is de-identified, and contains no personal health information (PHI). Our website collects names and email addresses via our contact form. This information is used solely by the administrators and members of the HCP website and is not shared, traded or sold to third parties under any circumstances. Our website may also collect non-personal data about site visits, sessions, and IP addresses. This information is only used for diagnostic or debugging purposes, to help us optimize our websites performance, and is not shared externally. This is a standard practice for most websites, and this data is never linked with personally identifiable information. This website contains links to other websites whose content we think is relevant. ...
The developing Human Connectome Project (dHCP) aims to create a detailed 4-dimensional connectome of early life spanning 20-45 weeks post-menstrual age. This is being achieved through the acquisition of multi-modal MRI data from over 1000 in- and ex-utero subjects combined with the development of optimised pre-processing pipelines. In this paper we present an automated and robust pipeline to minimally pre-process highly confounded neonatal resting-state fMRI data, robustly, with low failure rates and high quality-assurance. The pipeline has been designed to specifically address the challenges that neonatal data presents including low and variable contrast and high levels of head motion. We provide a detailed description and evaluation of the pipeline which includes integrated slice-to-volume motion correction and dynamic susceptibility distortion correction, a robust multimodal registration approach, bespoke ICA-based denoising, and an automated QC framework. We assess these components on a ...
The Human Connectome Project (HCP) has developed protocols, standard operating and quality control procedures, and a suite of informatics tools to enable high throughput data collection, data sharing, automated data processing and analysis, and data mining and visualization. Quality control procedures include methods to maintain data collection consistency over time, to measure head motion, and to establish quantitative modality-specific overall quality assessments. Database services developed as customizations of the XNAT imaging informatics platform support both internal daily operations and open access data sharing. The Connectome Workbench visualization environment enables user interaction with HCP data and is increasingly integrated with the HCPs database services. Here we describe the current state of these procedures and tools and their application in the ongoing HCP study. © 2013 Elsevier Inc.
Spontaneous fluctuations in activity in different parts of the brain can be used to study functional brain networks. We review the use of resting-state functional MRI (rfMRI) for the purpose of mapping the macroscopic functional connectome. After describing MRI acquisition and image-processing methods commonly used to generate data in a form amenable to connectomics network analysis, we discuss different approaches for estimating network structure from that data. Finally, we describe new possibilities resulting from the high-quality rfMRI data being generated by the Human Connectome Project and highlight some upcoming challenges in functional connectomics.
The Human Connectome Project (HCP) seeks to map the structural and functional connections between network elements in the human brain. Magnetoencephalography (MEG) provides a temporally rich source of information on brain network dynamics and represents one source of functional connectivity data to be provided by the HCP. High quality MEG data will be collected from 50 twin pairs both in the resting state and during performance of motor, working memory and language tasks. These data will be available to the general community. Additionally, using the cortical parcellation scheme common to all imaging modalities, the HCP will provide processing pipelines for calculating connection matrices as a function of time and frequency. Together with structural and functional data generated using magnetic resonance imaging methods, these data represent a unique opportunity to investigate brain network connectivity in a large cohort of normal adult human subjects. The analysis pipeline software and the dynamic
The Human Connectome Project (HCP) relies primarily on three complementary magnetic resonance (MR) methods. These are: 1) resting state functional MR imaging (rfMRI) which uses correlations in the temporal fluctuations in an fMRI time series to deduce functional connectivity; 2) diffusion imaging (dMRI), which provides the input for tractography algorithms used for the reconstruction of the complex axonal fiber architecture; and 3) task based fMRI (tfMRI), which is employed to identify functional parcellation in the human brain in order to assist analyses of data obtained with the first two methods. We describe technical improvements and optimization of these methods as well as instrumental choices that impact speed of acquisition of fMRI and dMRI images at 3T, leading to whole brain coverage with 2 mm isotropic resolution in 0.7 s for fMRI, and 1.25 mm isotropic resolution dMRI data for tractography analysis with three-fold reduction in total dMRI data acquisition time. Ongoing technical developments
The brain is a large-scale complex network often referred to as the connectome. Exploring the dynamic behavior of the connectome is a challenging issue as both excellent time and space resolution is required. In this context, Magneto/Electroencephalography (M/EEG) are effective neuroimaging techniques allowing for analysis of the dynamics of functional brain networks at scalp level and/or at reconstructed sources. However, a tool that can cover all the processing steps of identifying brain networks from M/EEG data is still missing. In this paper, we report a novel software package, called EEGNET, running under MATLAB (Math works, inc), and allowing for analysis and visualization of functional brain networks from M/EEG recordings. EEGNET is developed to analyze networks either at the level of scalp electrodes or at the level of reconstructed cortical sources. It includes i) Basic steps in preprocessing M/EEG signals, ii) the solution of the inverse problem to localize/reconstruct the cortical ...
Analysing computations in neural circuits often uses simplified models because the actual neuronal implementation is not known. For example, a problem in vision, how the eye detects image motion, has long been analysed using Hassenstein-Reichardt (HR) detector or Barlow-Levick (BL) models. These both simulate motion detection well, but the exact neuronal circuits undertaking these tasks remain elusive. We reconstructed a comprehensive connectome of the circuits of Drosophilas motion-sensing T4 cells using a novel EM technique. We uncover complex T4 inputs and reveal that putative excitatory inputs cluster at T4s dendrite shafts, while inhibitory inputs localize to the bases. Consistent with our previous study, we reveal that Mi1 and Tm3 cells provide most synaptic contacts onto T4. We are, however, unable to reproduce the spatial offset between these cells reported previously. Our comprehensive connectome reveals complex circuits that include candidate anatomical substrates for both HR and BL ...
Additional notes. Improved atlas surfaces and myelin maps. The Conte69 atlas dataset was derived from Freesurfer segmentation, surface reconstruction, and registration to the fsaverage left and right hemispheres, followed by interhemispheric registration to the left-right hybrid atlas, bringing the two hemispheres into geographic correspondence [1]. The current data release benefits from several refinements in surface generation and in the myelin mapping algorithm compared to the published data [1, 2]. Connectome Workbench data format. The Conte69 atlas dataset is also available in the new Connectome Workbench data format being developed for the Human Connectome Project. A beta-release of Connectome Workbench will be made available in the summer of 2012. REFERENCES. ...
Additional notes. Improved atlas surfaces and myelin maps. The Conte69 atlas dataset was derived from Freesurfer segmentation, surface reconstruction, and registration to the fsaverage left and right hemispheres, followed by interhemispheric registration to the left-right hybrid atlas, bringing the two hemispheres into geographic correspondence [1]. The current data release benefits from several refinements in surface generation and in the myelin mapping algorithm compared to the published data [1, 2]. Connectome Workbench data format. The Conte69 atlas dataset is also available in the new Connectome Workbench data format being developed for the Human Connectome Project. A beta-release of Connectome Workbench will be made available in the summer of 2012. REFERENCES. ...
The primate connectome, possessing a characteristic global topology and specific regional connectivity profiles, is well organized to support both segregated and integrated brain function. However, the organization mechanisms shaping the characteristic connectivity and its relationship to functional requirements remain unclear. The primate brain connectome is shaped by metabolic economy as well as functional values. Here, we explored the influence of two competing factors and additional advanced functional requirements on the primate connectome employing an optimal trade-off model between neural wiring cost and the representative functional requirement of processing efficiency. Moreover, we compared this model with a generative model combining spatial distance and topological similarity, with the objective of statistically reproducing multiple topological features of the network. The primate connectome indeed displays a cost-efficiency trade-off and that up to 67% of the connections were ...
This proposal is a continuation of our efforts to create a three-dimensional, Google Earth-like, digital Connectome atlas of the C57Black/6J mouse brain. Curren...
We interview Alastair Marriott with his work and life partner Jonathan Howells to talk choreography and neuroscience. The pair met as students at the Royal Ballet School but only began working together on professional projects recently. As choreographer, Marriott takes the lead while a work is initially developed. He explores ideas on his own before sharing them with dancers in a studio where their reactions influence the work. Once the principal shape of the choreography is determined Howells takes over and directs rehearsals. He must learn all the dancers movements and communicate Marriotts desired nuances and aesthetic. This allows to Marriott take some distance during rehearsals; keeping his eye sharp for fine-tuning.. Marriotts ballet, Connectome, explores the theory that every individual has a unique mental map that is shaped and coloured by events in their life. As a project of neuroscience, mental mapping remains largely underdeveloped so as creative stimulus it provides huge scope for ...
Recently the relation among activated human brain regions has drawn interests and has been investigated The imaging technique of functional magnetic resonance imagimg (fMRI) can be used to observe by changes in cerebral blood oxygenation and therefore brain connectivity To understand how white matter (WM) tractography influences brain connectivity we use diffusion magnetic resonance imagimg (dMRI) technique and algorithm to calculate WM map The connectivity measurement combining fMRI and dMRI datasets is called anatomically weighted functional connectivity (awFC) Finally the results show that when using awFC datasets the clusters have higher functional connectivity (FC) and structural connectivity (SC) strength when using awFC datasets ...
You are unique, just like everyone else.. Connectomics is the study of the structural and functional connections among brain cells; its product is the connectome, a detailed map of those connections. The idea is that such information will be monumental in our understanding of the healthy and diseased brain. Sebastian Seung thinks that a complete connectome of the human brain will be one of the great prizes in 21st-century neuroscience.. Efforts to construct brain connectomes are split into two categories: ones that use imaging techniques like MRI, PET, and DT, thus focusing on macroscopic connections or tracts; and those that use electron microscopy to map the tinniest of axons (0.2-20 microns in diameter) and individual synapses.. While this may sound daunting, it also seems the obvious thing to do in order to really understand how the brain works. After all, dont all our memories, personalities, and behaviors dependent on the structure of the brain, down to the microscopic level? So why is ...
TY - JOUR. T1 - The beginning of connectomics. T2 - A commentary on White et al. (1986) The structure of the nervous system of the nematode Caenorhabditis elegans. AU - Emmons, Scott W.. PY - 2015/1/1. Y1 - 2015/1/1. N2 - The article Structure of the nervous system of the nematode Caenorhabditis elegans (aka The mind of a worm) by White et al., published for the first time the complete set of synaptic connections in the nervous system of an animal. The work was carried out as part of a programme to begin to understand how genes determine the structure of a nervous system and how a nervous system creates behaviour. It became a major stimulus to the field of C. elegans research, which has since contributed insights into all areas of biology. Twenty-six years elapsed before developments, notably more powerful computers, made new studies of this kind possible. It is hoped that one day knowledge of synaptic structure, the connectome, together with results of many other investigations, will lead ...
While maps of young adult brains will be informative, several audience members expressed interest in seeing a developmental time course of brain connectivity. At the moment, looking at younger brains or healthy older brains is beyond the scope of the project, said Story Landis, who directs the National Institute for Neurological Disorders and Stroke. If the community embraces the current database, however, future projects to look at connectivity in other populations might get funded, she added. Since equipment and infrastructure are now in place, such add-on projects would have a smaller price tag, Landis pointed out. Many researchers in the Alzheimers field have shown that brain connectivity in key regions decreases as the disease advances, making this a hot topic for AD research (see ARF related news story; ARF news story; and ARF news story).. This project will be an important step in developing connectivity methods that can be used in AD research. The methods have great potential, and a ...
The exploration of the human connectome, a term denoting the global structural connectivity of the brain, is accessible to MRI at millimeter and centimeter scales. In this paper, we propose a methodology to map the connectome by constructing normalized whole-brain structural connection matrices derived from diffusion spectrum MRI tractography. Using a template-based approach, we propose a robust method that allows a) the selection of identical cortical regions of interest in different subjects with identification of the associated fiber tracts, b) a straightforward construction and interpretation of anatomically organized whole-brain connection matrices, and c) a statistical inter-subject comparison of brain connectivity.. Keywords: LTS5 ; diffusion MRI ; tractography ; connectivity. ...
In this work, we applied a multi-objective evolutionary approach to rewire brain networks and place them within an efficiency-complexity morphospace. Using various Pareto-optimal selection criteria, we were able to explore how brain networks evolve when subject to distinct selection pressures. Furthermore, the approach allowed us to investigate relationships and trade-offs between distinct topological traits associated with the principal axes of the morphospace, Ediff, Erout and CN. Our results demonstrate that the empirical networks we used as seed points for evolution are surrounded by a large space of variant network topologies, even when holding wiring cost constant, including networks that combine a higher capacity to support efficient communication with higher neural complexity.. Our work attempts to make several methodological contributions. First, building on fundamental work in evolutionary theory [44,51,52], we extend the morphospace analysis framework into the realm of human brain ...
Much of the CD4+ T-cell death that occurs during HIV infection may be caused by direct delivery of the virus from neighboring cells, a study shows.. 0 Comments. ...
Manipulate the default connectome provided with TVB to see how structural lesions effect brain dynamics. In this hands-on session you will insert lesions into the connectome within the TVB graphical user interface. Afterwards the modified connectome will be used for simulations and the resulting activity will be analysed using functional connectivity. ...
Manipulate the default connectome provided with TVB to see how structural lesions effect brain dynamics. In this hands-on session you will insert lesions into the connectome within the TVB graphical user interface. Afterwards the modified connectome will be used for simulations and the resulting activity will be analysed using functional connectivity. ...
We have just published a manuscript in PLoS Biology where we describe how to build a complete and accurate neural network. This of course is one of the long standing holy grails in neuroscience. So, this effort meets two goals: 1) It meets the goals of building a complete neural connectome (well be finished collecting all of the data with cell identity, physiologic response and all synaptic connectivity in approximately six days) and 2) It defines a workflow whereby investigators from around the planet can download and use the tools we are providing to build their own connectome projects using existing infrastructure. We are making those tools available here to enable other groups to assemble, browse and annotate the terabyte sized datasets required of connectome level projects.. The breakthroughs in this effort have largely centered on building a framework that can deal with ultrastructural image capture using Transmission Electron Microscopy (TEM) but greatly accelerates the data capture and ...
I would like to propose a metaphor for the relationship between neural activity and connectivity. Neural activity is constantly changing. Its like the water of the stream; it never sits still. The connections of the brains neural network determines the pathways along which neural activity flows. And so the connectome is like bed of the stream; but the metaphor is richer than that, because its true that the stream bed guides the flow of the water, but over long timescales, the water also reshapes the bed of the stream. And as I told you just now, neural activity can change the connectome. And if youll allow me to ascend to metaphorical heights, I will remind you that neural activity is the physical basis - or so neuroscientists think - of thoughts, feelings and perceptions. And so we might even speak of the stream of consciousness. Neural activity is its water, and the connectome is its bed ...
Despite recent advances, the tissue clearing technologies have a fundamental limitation: the working distance of optical microscopy. Without physical sectioning, an objective lens with high numerical aperture (≥1.2) for resolving submicron-resolution details does not have enough working distance (≥0.28 mm) to visualize cellular structures that are more than several millimeters deep. This limitation can be partially addressed by shrinkage-mediated imaging, which reduces the tissue volume after clearing (Pan et al., 2016). However, serial sectioning is still required for 3D imaging and reconstruction of large tissues.. Serial sectioning has been used with transmission EM to reconstruct the whole-body connectome of Caenorhabditis elegans (White et al., 1986; Xu et al., 2013) and larval Drosophila (Ohyama et al., 2015) as well as the partial optic medulla connectome in Drosophila (Takemura et al., 2013). However, the use of transmission EM in connectome reconstruction is limited by the ...
Because of the unique position of the topologically central role of densely interconnected brain hubs, our study aimed to investigate whether these regions and their related connections would be...
Abnormal rich-club metrics are a characteristic feature of PI-related to disease severity. These metrics provide potential clues to PI pathogenesis and may be useful as diagnostic markers and for assessment of treatment response.
For example, one discipline that has been quickly expanding and receiving much attention from the media is connectomics. The aim of this field is to create detailed maps, or connectomes, of all synaptic connections among neurons. This stands in contrast to other more conventional approaches that interrogate specific pathways and networks of connections among a restricted group of neurons. The generation of these connectomes has been strongly pursued through the development of techniques for high-resolution, high-throughput reconstruction of small volumes of nervous tissue. For example, recent work by Kasthuri et al (2015) shows the potential of new electron microscopy (EM) techniques for expanding our understanding of the connections and structure of the brain. Unlike other forms of histology that rely on fluorescence to visualize cells, EM generates high-resolution images that reveal all membranous structures. Kasthuri and colleagues have imaged a square volume of brain slice after brain slice, ...
The DiCIPHR lab focuses on understanding the structural and functional connectivity in the brain when it is healthy, and the ways the connectivity is altered as a result of disease. This is achieved by developing advanced mathematical and computational tools for various aspects of diffusion MRI analysis, as well as multimodal connectomics with applications in the clinic. These tools have enabled investigations in sex differences, healthy brain development, communication scheme brain assumes, autism, brain cancer, and traumatic brain injury. In addition to population-based studies that elucidate imaging patterns of disease, the lab aims to develop subject-specific imaging biomarkers paving the way for precision imaging. Twitter: https://twitter.com/DiCIPHR ...
Markett, S., Montag, C., Heeren, B., Saryiska, R., Lachmann, B., Weber, B., & Reuter, M. (2016). Voxelwise eigenvector centrality mapping of the human functional connectome reveals an influence of the catechol-O-methyltransferase val158met polymorphism on the default mode and somatomotor network. Brain Structure and Function, 221(5), 2755-2765 ...
Mendes, N.; Oligschläger, S.; Lauckner, M.; Golchert, J.; Huntenburg, J. M.; Falkiewicz, M.; Ellamil, M.; Krause , S.; Baczkowski, B.; Cozatl, R. et al.; Osoianu, A.; Kumral, D.; Pool, J.; Golz, L.; Paerisch, M.; Haueis, P.; Jost , R.; Kramarenko, Y.; Engen, H. G.; Ohrnberger, K.; Gorgolewski, K. J.; Farrugia, N.; Babayan, A.; Reiter, A.; Schaare, H. L.; Reinelt, J.; Röbbig, J.; Uhlig, M.; Erbey, M.; Gaebler, M.; Smallwood, J.; Villringer, A.; Margulies, D. S.: A functional connectome phenotyping dataset including cognitive state and personality measures. Scientific Data 6, 180307 (2019 ...
Cerebral small vessel disease (SVD) is an important cause of vascular cognitive impairment. Recent studies have demonstrated that structural connectivity of brain networks in SVD is disrupted. However, little is known about the extent and location of the reduced connectivity in SVD. Here they invest …
Nodes were more prone to disease when they were linked by shorter or stronger functional connections. In other words, the transneuronal spread model best fit disease progression.. While Seeleys group started with the data and asked what models best fit, Raj and colleagues came at it from the opposite direction. They built a biophysical model and fit to it MRI data from healthy, AD, and FTD brains. These scientists propose that toxic proteins diffuse through the brain in a classic mechanism whereby concentration gradients drive their random dispersion. This, they posit, follows brain connectivity networks. Their so-called network diffusion model precisely recapitulated the pattern of atrophy progression of AD and behavioral variant frontotemporal dementia. It might even be able to predict what brain regions will atrophy in the future based on baseline MRI morphometrics, Raj and colleagues write.. How can these new models help researchers? Can they aid in diagnosis or prognosis? The authors claim ...
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A new paper in the open access journal PLoS Biology describes a new way to model the human brain using diffusion spectrum imaging. Since were in the omics age of science, you shouldnt be surprised that this map is dubbed the connectome. The semantics of the connectome is similar to genome, proteome, metabalome, transcriptome --…
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Case #1: The Toll-like receptor 3 (TLR3) gene, discovered in the Casanova lab years earlier, causes the life-threatening brain inflammation herpes simplex virus 1 encephalitis (HSE) in children. TLR3 controls innate immunity, impairing a specific interferon.. The human gene connectome produced results both expected and not. We took 2 patients who had HSE and had very recently been discovered to have a disease-causing gene called TBK1, Dr. Itan told me. So we thought if we take gene variations and run them by their distance to TLR3, would TBK1 show up? In both patients, it showed up first, purely based on this computational prediction. The TLR3-specific connectome revealed two novel TLR3 pathway genes prior to their experimental validation - EFGR and SRC.. In a second test case, a mutation in a collagen gene that causes a form of Ehlers-Danlos syndrome pulled out 26 other genes associated with the Ehlers-Danlos syndrome and its genetic pathway.. Finding new genes behind what was thought to be ...
Every first Friday, 3:30 PM in CIRC 120. We will discuss new ideas and techniques in brain imaging. List of speakers in Visual Brain Core Seminar Series Past Seminars Nov 21, 2014: White Matter in the Older Brain is More Plastic than in the Younger Brain Speaker: Yuka Sasaki, PhD, Department of Cognitive, Linguistic and Psychological Sciences, Brown University. Jan 9, 2014 : UAB Research Computing Resources for Neuroimaging Research Speakers: John-Paul Robinson, Mike Hanby, Thomas Anthony Feb 6, 2015: High Gradient Diffusion MRI from the Human Connectome Project Speaker: Koene Van Dijk, PhD, Department of Radiology, Harvard Medical School. March 6, 2015: How do we measure functional connectivity? An interactive discussion of functional connectivity methods Speaker: Kristina Visscher, PhD, University of Alabama at Birmingham. Future Seminars April 3, 2015: Generalized Psychophysical Interactions (gPPI): What are they and What they can tell us Speaker: Donald McLaren, PhD, Department of ...
This study examined functional neural predictors of response to EX/RP therapy in unmedicated patients with OCD using a nonaffective cognitive control task. Using up-to-date acquisition and processing methods in line with large-scale studies (e.g., Human Connectome Project [HCP]), group differences in conflict-related responses did not withstand rigorous multiple comparisons correction. However, greater conflict-related activity predicted greater EX/RP response in 36 parcels/regions (of the 374 tested), mainly within cingulo-opercular (e.g., anterior insula, anterior cingulate) and default mode network (DMN; e.g., posterior cingulate, angular gyrus) regions, as well as the DLPFC, pallidum, and areas of visual cortex. Moreover, conflict-related activity on its own predicted which patients achieved remission (operationalized as posttreatment Y-BOCS score ≤ 12) with relatively high sensitivity and specificity. This increased even further to nearly complete separation of which patients achieved ...
TY - JOUR. T1 - Personality and resting state networks in children. T2 - A longitudinal EEG study. AU - Knyazev, Gennady G.. AU - Savostyanov, Alexander N.. AU - Bocharov, Andrey V.. AU - Slobodskaya, Helena R.. AU - Bairova, Nadezhda B.. PY - 2017/11/1. Y1 - 2017/11/1. N2 - The association of personality with resting state networks has been investigated in the mature brain, but its development has not been investigated, particularly in longitudinal design. Besides, all existing evidence is obtained using functional magnetic resonance imaging and there are no data on electrophysiological underpinning of these associations. We have acquired three yearly recordings of resting state EEG data in primary school children. Parental ratings of childs personality were obtained in the third wave. Seed-based oscillatory power envelope correlation analysis in conjunction with beamformer spatial filtering were used to obtain electrophysiological signatures of the default mode network (DMN) associated with ...
The goal of our research is to understand use-driven brain network plasticity in children with brain injury, in order to develop novel neurorehabilitative treatments. To this end, we are studying childrens brains using resting state functional connectivity MRI (rs-fcMRI) and task-based functional MRI (fMRI). We are focused on pushing structural and functional MRI acquisition and analysis methodology to the level of individual patients. In order to create and annotate the connectomes of individuals (Individuomes) we must first improve the signal-to-noise, spatial resolution and replicability of fMRI and rs-fcMRI data. High-fidelity Individuomes should help accelerate fMRI-based diagnostics and neurofeedback rehabilitation therapy.. One of the main complications for rs-fcMRI and fMRI in children is excessive head movement, which introduces systematic distortions. Post-hoc data censoring methods can remove movement artifact from rs-fcMRI data, but in children post-hoc censoring leads to ...
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We have a new publication out (Direct Link, Free Open Access), Retinal Remodeling in Human Retinitis Pigmentosa authored by Bryan W. Jones, Rebecca Pfeiffer, Drew Ferrell, Carl Watt, Michael Marmor and Robert Marc.. Abstract: Retinitis Pigmentosa (RP) in the human is a progressive, currently irreversible neural degenerative disease usually caused by gene defects that disrupt the function or architecture of the photoreceptors. While RP can initially be a disease of photoreceptors, there is increasing evidence that the inner retina becomes progressively disorganized as the outer retina degenerates. These alterations have been extensively described in animal models, but remodeling in humans has not been as well characterized. This study, using computational molecular phenotyping (CMP) seeks to advance our understanding of the retinal remodeling process in humans. We describe cone mediated preservation of overall topology, retinal reprogramming in the earliest stages of the disease in retinal ...
We have a new manuscript out in Clinical Neurophysiology, An Update on Retinal Prostheses. PubMedDirect Link PDF here.. Authors: Lauren N. Ayton, Nick Barnes, Gislin Dagnelie, Takashi Fujikado, Georges Goetz, Ralf Hornig, Bryan W. Jones, Mahiul M.K. Muqit, Daniel L. Rathbun, Katarina Stingl, James D. Weiland, Matthew A. Petoe.. Abstract: Retinal prostheses are designed to restore a basic sense of sight to people with profound vision loss. They require a relatively intact posterior visual pathway (optic nerve, lateral geniculate nucleus and visual cor- tex). Retinal implants are options for people with severe stages of retinal degenerative disease such as retinitis pigmentosa and age-related macular degeneration.. There have now been three regulatory-approved retinal prostheses. Over five hundred patients have been implanted globally over the past 15 years. Devices generally provide an improved ability to localize high-contrast objects, navigate, and perform basic orientation tasks. Adverse ...
Methodology to annotate the multiple origins of axonal projections in dense electron microscopy data of mammalian nervous tissue without the need of chemical label conversion is reported.
The Society for Human Resource Management (SHRM) is the leading voice of the human resource profession, representing the interests of over 60,000 professional and 6,000 student members around the world.. SHRM provides its members with educational and informational services, conferences and seminars, government and media representation, and publications that equip human resource professionals for their roles as leaders and decision-makers within their organizations. The society is a founding member and Secretariat of the World Federation of Personnel Management Associations (WFPMA), which links human resource associations in 55 nations.. As a national student member of the society, you will learn about the real world of human resource management (HRM) through award-winning publications and educational opportunities. Join one of over 300 student chapters located at colleges and universities throughout the United States and Puerto Rico. Participate in activities that will build your knowledge of ...
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This abstract was presented today at the 2014 Association for Research in Vision and Opthalmology (ARVO) meetings in Orlando, Florida by J Scott Lauritzen, Noah T. Nelson, Crystal L. Sigulinsky, Nathan Sherbotie, John Hoang, Rebecca L. Pfeiffer, James R. Anderson, Carl B. Watt, myself and Robert E. Marc.. Purpose: Despite large-scale efforts aimed at mapping the mammalian nervous system, the entire synaptic cohort of a single mammalian neuron of any class has never been mapped. To this end we reconstructed all chemical and electrical synaptic partners of a single ON cone bipolar cell in the inner plexiform layer (IPL) of the rabbit retina. We then searched all members of the same cell class for repeating network motifs and explored postsynaptic cell sampling topologies from this bipolar cell.. Methods: Cells in retinal connectome 1 (RC1) were annotated with Viking viewer, and explored via graph visualization of connectivity and 3D rendering (Anderson et al., 2011 J Microscopy). Small molecule ...
BRAIN SCIENTISTS the world over have tinkered with capturing a complete model of the human brain for the purposes of achieve a full understanding its how it functions. The amount of information required about the human brain operations has exploded. From image captures focused on individual neurons to whole scale network tracings of the brain connectome, and from the creative and destructive roles of glial cells, numerous efforts are underway to achieve computational representation of the brains 10^11 neurons, each with 10^4 synapses, and the action potentials 100 billion neurons.. A lingering related question is what would happen if a fully specified computational model - a simulation - of the human brain was built? More precisely, what would happen if it were turned on? Would it, or more precisely could it, perceive consciousness? Could it be taught? What would it think about? What would it think about itself? What would think about us?. There has been success in building simulations of ...
Biologically-reliable computer simulation of the nervous system is the cross-disciplinary area of research which is quite novel and mostly related to neurobiology, neurocybernetics and artificial intelligence. The main idea is to study the mechanisms of brain functioning by means of investigation of its work in details at neuronal and subneuronal level (membranes, neurites, neuromediators, ion channels etc.) and implementation of this data and knowledge within a dynamic model. Its quite obvious to start from the most simple organism to test the overall conception, and continue with more complex ones in case of success. For this purpose C. elegans nematode is currently the only animal with almost known neural network architecture (connectome). Moreover, its structure, including neurons positions, morphological features and interneuron connections is invariant for all animals of one sex. Relative simplicity but still quite complex behavioral patterns, as well as abilities for learning and memory ...
Large-scale neural model of visual short term memory embedded into a 998-node connectome. The model simulates electrical activity across neuronal populations of a number of brain regions and converts that activity into fMRI and MEG time-series. The model uses a neural simulator developed at the Brain Imaging and Modeling Section of the National Institutes of Health ...
Large-scale neural model of visual short term memory embedded into a 998-node connectome. The model simulates electrical activity across neuronal populations of a number of brain regions and converts that activity into fMRI and MEG time-series. The model uses a neural simulator developed at the Brain Imaging and Modeling Section of the National Institutes of Health ...
Whitaker, K. J.; Vértes, P. E.; Romero-Garcia, R.; Vása, F.; Moutoussis, M.; Prahub, G.; Weiskopf, N.; Callaghan, M. F.; Wagstyl, K.; Rittmann, T. et al.; Tait, R.; Ooi, C.; Suckling, J.; Inkster, B.; Fonagy, P.; Dolan, R. J.; Jones, P. B.; Goodyer, I. M.; the NSPN Consortium; Bullmore, E. T.: Adolescence is associated with genomically patterned consolidation of the hubs of the human brain connectome. Proceedings of the National Academy of Sciences of the United States of America 113 (32), pp. 9105 - 9110 (2016 ...
Mechling AE, Arefin T, Lee H-L, Bienert T, Reisert M, Ben Hamida S, Darcq E, Ehrlich A, Gaveriaux-Ruff C, Parent MJ et al.. 2016. Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome.. Proc Natl Acad Sci U S A. 113(41):11603-11608. ...
Mechling AE, Arefin T, Lee H-L, Bienert T, Reisert M, Ben Hamida S, Darcq E, Ehrlich A, Gaveriaux-Ruff C, Parent MJ et al.. 2016. Deletion of the mu opioid receptor gene in mice reshapes the reward-aversion connectome.. Proc Natl Acad Sci U S A. 113(41):11603-11608. ...
Todays Water Cooler: Impeachment v. trade bill, France v. US, US v. China, Biden, Buttigieg, Sanders, Warren, Jewish-Americans, Stacey Abrams, employment, manufacturing, services, shipping, potatoes, another IoT debacle, P4HCAF, prison staffing, slavery, the connectome, the Dead
杭州师范大学静息态功能磁共振影像免费培训(第四期). 2019年04月14日(周日) 13:00-17:00. 主办单位:. 杭州师范大学心理科学研究院. 杭州师范大学附属医院认知与脑疾病研究中心. 浙江省认知障碍评估技术研究重点实验室. 承办单位:. 杭州拾睿科技有限公司. 为了加强社会服务,杭州师范大学拟针对静息态功能磁共振影像研究者开展免费培训服务,暂定每月一次。. 第四期讲座的题目为Resting-state fMRI and state fMRI Design: data analysis and application,时间定于2019年04月14日13:00-17:00。本次讲座主要面向心理学领域从事静息态功能磁共振影像或拟采用state任务fMRI设计的研究者,通过QQ网络的方式进行。感兴趣的朋友请填写附件中的报名表格,并发送邮件至贾熙泽([email protected])。. 讲者及简介:. 1. 题目:Resting-state fMRI and state fMRI ...
Connectomics and Cortical Transistors Margie shares; German scientists have recently discovered a precise nerve cell connectivity pattern (nerve cell circuits) in part of the cerebral cortex, which is responsible for orienting us in space. These grid cells provide a very particular representation of the space around the individual human and are known to be active when we are located at highly ordered grid-like locations in a room or a large space.. Read more within the following articles and research;. ...
This work was supported by National Institutes of Health DC 016293 and USAFOSR FA9550-17-1-0117 to A.M.D.; Howard Hughes Medical Institute Janelia Research Campus Visiting Scientist Program project to A.M.D. and K.E.C.; and Wellcome Trust Collaborative Award 203261/Z/16/Z and National Institutes of Health RF1 MH120679 01 Award to D.D.B. The Howard Hughes Medical Institute supported the generation and hosting of the FAFB dataset. We thank the FAFB tracing community for helpful insights and contributions of neuron tracings; Tom Kazimiers and Andrew Champion for CATMAID development; Peter Li for development of the autosegmented instance of the FAFB dataset; Eric Perlman for making the autosegmented dataset available in CATMAID; the Cambridge Drosophila Connectomics group, especially Greg Jefferis, Marta Costa, Philipp Schlegel, Alex Bates, Ruairi Roberts, Robert Turnbull, Lisa Marin, and Nik Drummond for use of hundreds of neuron reconstructions, assistance with custom analyses, and facilitating ...
Alison Calder, raised and partly educated in Saskatoon, is now a professor of literature at the University of Manitoba and a poet and critic with numerous publications to her credit. In the fascinating Connectomics she writes of neural pathways, where various emotions and memories are stored in the brain, and how we go about mapping that still mysterious organ in our skulls.. Whats most fascinating about this small collection is not the science itself, which has its appeal, but the way in which Calder toys with the idea of how to describe a place so important to us but to which so very few of us go, or even care to know. The brain, to most people, is just the brain until something goes wrong with it, but right now thousands of scientists are mapping it and trying to understand its functions. In Infinity Calder opens, After we exhausted wonder/ we shut down the computers, turned off/ the lights. Everything/ was known, and ends, We grew our knowledge right up to the end./ When we got to the ...
Focused Ion Beam Scanning Electron Microscopy (FIB-SEM) can automatically generate 3D images with superior z-axis resolution, yielding data that needs minimal image registration and related post-processing. Obstacles blocking wider adoption of FIB-SEM include slow imaging speed and lack of long-term system stability, which caps the maximum possible acquisition volume. Here we present techniques that accelerate image acquisition while greatly improving FIB-SEM reliability, allowing the system to operate for months and generating continuously imaged volumes , 10(6) µm(3). These volumes are large enough for connectomics, where the excellent z resolution can help in tracing of small neuronal processes and accelerate the tedious and time-consuming human proofreading effort. Even higher resolution can be achieved on smaller volumes. We present example data sets from mammalian neural tissue, Drosophila brain, and Chlamydomonas reinhardtii to illustrate the power of this novel high-resolution technique ...
Researchers have developed reconstruction software that allows them to gain an about 10-fold speedup for data analysis in connectomics.
Genomics was driven by increasing technology and was addictive, because, it is not too cynical to say, it was thought-free, meat-grinder, factory science. It was lucrative, did indeed teach us a lot about what genes and genomes do, and found a modest number of important causal genes. Its success, at least in the fashion and funding senses, understandably spawned other hypothesis-free blind technological approaches, cashing in on the cachet of the omics word and its rejection of the need for actual prior hypotheses to design studies: nutriomics, connectomics, metabolomics, microbiomics, immunomics, epigenomics, and more. How much of this was because the same people who were promising us that successful disease prediction with genetics was right around the corner realized that this just wasnt true, and needed to figure out ways to keep their labs running we cant say, but we certainly are a fad-following, money-following research culture and we know this is part of the story. To be fair, when ...
Interest in brain connectivity inference has become ubiquitous and is now increasingly adopted in experimental investigations of clinical, behavioral, and experimental neurosciences. Methods in Brain
How does the brain integrate multiple sources of information to support normal sensorimotor and cognitive functions? To investigate this question we present an overall brain architecture (called
Provides the latest translational research discoveries in brain mapping, modeling, novel research techniques, and more in the rapidly advancing field of connectivity research at the systems and network levels.
Principal Investigator:Matsumoto Riki, Project Period (FY):2014-04-01 - 2016-03-31, Research Category:Grant-in-Aid for Challenging Exploratory Research, Research Field:Brain biometrics
Improve the performance of your progressive scan video sources with the Universal 3 Component Video Cable. The oxygen-free copper center conductor and foam PE dielectric maintain a 75 Ohm characteristic impedance, and offer efficient signal transmissio
通常情况下,任务会选择高通滤波,选择的频点是0.008HZ,也就是每128s一周期。静息状态下一般选择带通滤波,具体选哪段,不好说,没有统一的标准。你用脑电的频段对fMRI数据滤波,这个没道理。通常情况下,fMRI数据全脑扫描高频率也不会超过1HZ,你取1HZ以上的频段,是没有信号的,自然什么结果都没有。. ...
The connectome can be studied as a network by means of network science and graph theory. In case of a micro-scale connectome, ... The term "connectome" was more recently popularized by Sebastian Seung's I am my Connectome speech given at the 2010 TED ... The Budapest Reference Connectome has led the researchers to the discovery of the Consensus Connectome Dynamics of the human ... Other developmental connectomes, such as the muscle connectome, retain some global network properties even though the number of ...
A natural question is whether the connectome will allow simulation of the fly's behavior. However, the connectome alone is not ... Detailed circuit-level connectomes exist for the lamina and a medulla column, both in the visual system of the fruit fly, and ... The Drosophila connectome, once completed, will be a complete list of the roughly 135,000 neurons in the brain of the fruit fly ... A full connectome of a large portion of the central brain is likewise available. Many of the 76 compartments of the Drosophila ...
... a human being's connectome could be simulated and 'uploaded' onto a computer". Daniel Levitin praised Connectome as "the best ... Connectome, p. 169 Seung reviews the history of mapping the Caenorhabditis elegans connectome by Sydney Brenner and colleagues ... Connectome: How the Brain's Wiring Makes Us Who We Are (2012) is a book by Sebastian Seung. It introduces basic concepts in ... You are your connectome." Seung introduces the 19th-century idea of phrenology and its modern-day counterpart, which he calls " ...
"Connectome - HCP Lifespan Studies". www.humanconnectome.org. Retrieved 2017-12-13. UpAndRunning. "Connectome - Human Connectome ... The studies fall into three categories: Healthy Adult Connectomes, Lifespan Connectome Data, and Connectomes Related to Human ... Related Connectome Projects The umbrella site for all Human Connectome Project work funded by the NIH Open Connectome Project ... The goal of the Human Connectome Project is to build a "network map" (connectome) that will shed light on the anatomical and ...
"Parameterizable consensus connectomes from the Human Connectome Project: the Budapest Reference Connectome Server v3.0". ... The Budapest Reference Connectome has led the researchers to the discovery of the Consensus Connectome Dynamics of the human ... It has been prepared from diffusion MRI datasets of the Human Connectome Project into a reference connectome (or brain graph), ... There is an option for viewing and comparing the female or male reference connectomes. The connectomes of women contain ...
"Sequencing the Connectome: Will DNA Bar Codes and a Sneaky Virus Change the Way Scientists Map the Brain?". Scientific American ... Zador AM, Dubnau J, Oyibo HK, Zhan H, Cao G, Peikon ID (2012). "Sequencing the Connectome". PLOS Biology. 10 (10): e1001411. ... More recently, he has pioneered a new approach to connectome mapping using the methods of molecular biology, which may ...
Zador AM, Dubnau J, Oyibo HK, Zhan H, Cao G, Peikon ID (2012). "Sequencing the connectome". PLOS Biology. 10 (10): e1001411. ... Colon-Perez LM, Tanner JJ, Couret M, Goicochea S, Mareci TH, Price CC (March 1, 2018). "Cognition and connectomes in ... The macroscopic scale is best suited for mapping and annotating human connectomes, a comprehensive map of neural connections, ... Leergaard TB, Hilgetag CC, Sporns O (2012). "Mapping the connectome: multi-level analysis of brain connectivity". Frontiers in ...
Dick, Anthony Steven; Bernal, Byron; Tremblay, Pascale (15 December 2013). "The Language Connectome". The Neuroscientist. 20 (5 ...
An Interactive Connectome". Frontiers in Neuroinformatics. 5: 7. doi:10.3389/fninf.2011.00007. ISSN 1662-5196. PMC 3147162. ...
Connectome Connectomics Human Connectome Project Brain mapping Tractography Chord diagram (information visualization) Irimia, ... "Human Connectome Project". NIH. "Hard Cell". The Economist. 9 March 2013. Retrieved 11 March 2013. "Introduction to Circos, ... Most other representations of the connectome use 3 dimensions, and therefore require an interactive graphical user interface. ... "Imaging human connectomes at the macroscale". Nature Methods. 10 (6): 524-39. doi:10.1038/nmeth.2482. PMC 4096321. PMID ...
Leergaard, Trygve (2011). Mapping the Connectome. Frontiers. p. 135. ISBN 978-2889191079. "Center for Peacemaking Practice". ...
... "functional connectome", as well as new technologies that will have to be developed in the course of the project. They indicated ... "Sequencing the Connectome". PLOS Biology. 10 (10): e1001411. doi:10.1371/journal.pbio.1001411. PMC 3479097. PMID 23109909. "NIH ... Therapeutic Scientific Summit Human Connectome Project List of animals by number of neurons List of neuroscience databases ...
Barch is a Principal Investigator of the Human Connectome Project-Development, which aims to map the development of brain ... "HCP Development - Connectome - Publications". www.humanconnectome.org. Retrieved 2022-07-19. "Deanna Barch, PhD Developmental ...
The other concept is called the Dynamic Pain Connectome which emphasizes that spatiotemporal representation of pain in the ... Kucyi, Aaron; Davis, Karen D. (1 February 2015). "The dynamic pain connectome". Trends in Neurosciences. 38 (2): 86-95. doi: ... "The dynamic pain connectome.]". Trends Neurosci. 38 (2): 86-95. doi:10.1016/j.tins.2014.11.006. PMID 25541287. S2CID 745129.{{ ... From Single-Cell Electrophysiology to the Dynamic Pain Connectome.]". Neuroscientist. 23 (4): 397-414. doi:10.1177/ ...
"Muse Launch Social Connectome , Altsounds.com News". Hangout.altsounds.com. 21 September 2012. Archived from the original on 23 ... The album's cover art features a map of the human brain's pathways, which was taken from the Human Connectome Project. The ... The album's cover art, taken from the Human Connectome Project, represents the map of the human brain's pathways, "tracking the ... The artwork was subsequently used by Muse in a social Connectome Project on 21 September 2012. As more fans joined the online ...
As well as work directly within her research group, she is a collaborator on the developing Human Connectome Project (dHCP), a ... "Teams and Collaborators , The Developing Human Connectome Project". www.developingconnectome.org. "Scientific Committee". www. ...
Picchioni, Dante; Duyn, Jeff H.; Horovitz, Silvina G. (15 October 2013). "Sleep and the functional connectome". NeuroImage. 80 ... "The structural-functional connectome and the default mode network of the human brain". NeuroImage. 102: 142-151. doi:10.1016/j. ...
To see one of the first micro-connectomes at full-resolution, visit the Open Connectome Project, which is hosting several ... The larger eigengap shows that the female connectome is better expander graph than the connectome of males. The better ... The human connectome can be viewed as a graph, and the rich tools, definitions and algorithms of the Graph theory can be ... Dynamic Functional Connectivity List of Functional Connectivity Software Human Connectome Project Budapest Reference Connectome ...
Bibliome Connectome Cytome Editome Embryome Epigenome Methylome Exposome Envirome Toxome Foodome Microbiome Sociome Genome ... Kopell, Nancy J.; Gritton, Howard J.; Whittington, Miles A.; Kramer, Mark A. (2014-09-17). "Beyond the connectome: the dynome ... DeFelipe, Javier (2010-11-26). "From the Connectome to the Synaptome: An Epic Love Story". Science. 330 (6008): 1198-1201. ... Moleculome Glycome Ionome Lipidome Metabolome Volatilome Metallome Proteome Obesidome Organome Phenome Physiome Connectome ...
Functional Connectome of the Fetal Brain. J Neurosci. 2019 Dec 4;39(49):9716-9724. doi: 10.1523/JNEUROSCI.2891-18.2019. Epub ...
It is then possible to trace each motor axon and its synaptic contacts to construct a complete connectome of the muscle. More ... Lichtman, Jeff; Jean Livet; Joshua Sanes (June 2008). "A technicolour approach to the connectome". Nature Reviews Neuroscience ...
Lichtman JW, Livet J, Sanes JR (2008). "A technicolour approach to the connectome". Nat Rev Neurosci. 9 (6): 417-22. doi: ... Sample I (7 May 2012). "Quest for the connectome: scientists investigate ways of mapping the brain". The Guardian. Retrieved 9 ... to construct a full connectome of the mouse retina. The lab is also interested in inhibitory interneurons in the prefrontal ...
"Parameterizable consensus connectomes from the Human Connectome Project: the Budapest Reference Connectome Server v3.0". ... "How to Direct the Edges of the Connectomes: Dynamics of the Consensus Connectomes and the Development of the Connections in the ... The connectome can be constructed from diffusion MRI data: the vertices of the graph correspond to anatomically labelled gray ... The Consensus Connectome Dynamics (CCD) is a remarkable phenomenon that was discovered by continuously decreasing the minimum ...
"Multimodal mapping of the face connectome". Nature Human Behaviour. 4 (4): 397-411. doi:10.1038/s41562-019-0811-3. PMC 7167350 ...
... forms a parallel wireless connectome whose topological features and modes of interaction with the wired connectome could be ... "The Multilayer Connectome of Caenorhabditis elegans". PLOS Computational Biology. 12 (12): e1005283. arXiv:1608.08793. Bibcode: ... elegans neural connectome. In particular, he recognised that neuromodulatory signaling, being largely extrasynaptic, ... "Network control principles predict neuron function in the Caenorhabditis elegans connectome". Nature. 550 (7677): 519-523. ...
April 2014). "A mesoscale connectome of the mouse brain". Nature. 508 (7495): 207-14. Bibcode:2014Natur.508..207O. doi:10.1038/ ...
In 2021, the first connectome that shows how an animal's brain changes throughout its lifetime was reported. Scientists mapped ... At higher resolutions brain maps are called connectomes. These maps incorporate individual neural connections in the brain and ... Shi, Y (May 2017). "Connectome imaging for mapping human brain pathways". Nature. 22 (9): 1230-1240. doi:10.1038/mp.2017.92. ... "Connectomes across development reveal principles of brain maturation". Nature. 596 (7871): 257-261. Bibcode:2021Natur.596..257W ...
Varoquaux, Gaël; Craddock, R. Cameron (October 2013). "Learning and comparing functional connectomes across subjects". ... Connectome Neuroanatomy Stereotaxic atlas Stereotaxy Beliveau, Vincent; Ganz, Melanie; Feng, Ling; Ozenne, Brice; Højgaard, ...
"Parameterizable consensus connectomes from the Human Connectome Project: the Budapest Reference Connectome Server v3.0". ... The connectome, or the braingraph, can be constructed from diffusion MRI data: the vertices of the graph correspond to ... The Budapest Reference Connectome Server depicts the cerebral connections of n=418 subjects with a frequency-parameter k: For ... The Consensus Connectome Dynamics (CCD) is a remarkable phenomenon that was discovered by continuously decreasing the minimum ...
... and other uses in biology connectome, proteome; biome, rhizome, vacuome -on < electron (see also -tron) an elementary particle ...
Connectome Newsletter. Register now to receive our Connectome - News several times a year. ...
a comprehensive map of neural connections in the brain; may be thought of as the brains wiring diagram. Three musical reflections on the possible futures that the wiring of the human brain might eventually lead us to. ...
This neurochemical connectome is terminologically consistent and shares several network invariants with mouse and macaque ... ChemNetDB provides the first whole-brain, multiscale, and consistently collated rat connectome database. ChemNetDB also ...
SfN Global Connectome. Join us for the SfN Global Connectome from January 11 to 13. Our colleagues from PCO-Tech will be glad ...
Connectome is a mind-bending adventure story, told with great passion and authority. It presents a daring scientific and ... Seung explains how this new map of a human "connectome" might even enable us to "upload" our brains into a computer, making us ... Connectome: How the Brains Wiring Makes Us Who We Are. December 5, 2011. ...
Get Connectome Workbench!. Version 1.5.0 of the Connectome Workbench is now publicly available for download for Mac, Windows ... The Human Connectome Project and Connectome Coordination Facility are funded by the National Institutes of Health, and all ... Privacy Statement for the Human Connectome Project and Connectome Coordination Facility. Privacy Statement. The member ... CONNECTOME DB BACKEND COMMAND FOR CIFTI AVERAGE DENSE ROI -backend-average-roi-correlation CONNECTOME DB BACKEND COMMAND FOR ...
Deep Brain Stimulation induced normalization of the human functional connectome in Parkinsons Disease. View ORCID Profile ... The recently defined framework of the human connectome allows to globally analyse parts of the brain and their ... Deep Brain Stimulation induced normalization of the human functional connectome in Parkinsons Disease ... Deep Brain Stimulation induced normalization of the human functional connectome in Parkinsons Disease ...
The Human Connectome Project and Connectome Coordination Facility are funded by the National Institutes of Health, and all ... Privacy Statement for the Human Connectome Project and Connectome Coordination Facility. Privacy Statement. The member ... BANDA: Connectomes Related to Anxiety & Depression * Changes in Visual Cortical Connectivity Following Central Visual Field ... Mapping Connectomes for Disordered Mental States * Neural Disconnection & Errant Visual Perception in Psychotic Psychopathology ...
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Title:What makes us humans: Differences in the critical dynamics underlying the human and fruit-fly connectome. Authors:Géza ... Now we investigate this on the largest available brain network, the $21.662$ node fruit-fly connectome, using the Kuramoto ... Abstract: Previous simulation studies on human connectomes suggested, that critical dynamics emerge subcrititcally in the so ... but much smaller than as for the KKI-18 human connectome. This demonstrates the effect of modular structure and dimension on ...
These first-ever mammalian connectomes, or complete neural circuit diagrams, reveal that neural wiring can vary widely even ... Diverse connectomes hint at genes limits in the nervous system. Axons in the connectomes of the left and right ... in each connectome. Thus each axon and its contralateral counterpart can be identified in the connectomes, and subsequently ... Curiously, the connectome of the mouse interscutularis -- a muscle also found in dogs, rats, and other mammals that readily ...
Our comprehensive connectome reveals complex circuits that include candidate anatomical substrates for both HR and BL types of ... We reconstructed a comprehensive connectome of the circuits of Drosophilas motion-sensing T4 cells using a novel EM technique ... The comprehensive connectome of a neural substrate for ON motion detection in Drosophila. ... The comprehensive connectome of a neural substrate for ON motion detection in Drosophila ...
Using lesions masks and structural connectome template to estimate structural connectomes in a stroke population where we can ... Damage to the structural connectome reflected in resting-state fMRI functional connectivity In Special Collection: CogNet ... The resulting model of structural connectivity shown in Figure 1 is referred to as the structural connectome (SC). We use the ... Virtual tractography is a new approach (Kuceyeski et al., 2013; Pustina et al., 2017) to estimating structural connectomes in a ...
Home > PATIENT-TAILORED PREDICTIONS OF GRAY MATTER ATROPHY IN ALZHEIMERS DISEASE BASED ON BASELINE FLORTAUCIPIR AND CONNECTOME ... PATIENT-TAILORED PREDICTIONS OF GRAY MATTER ATROPHY IN ALZHEIMERS DISEASE BASED ON BASELINE FLORTAUCIPIR AND CONNECTOME-BASED ... PATIENT-TAILORED PREDICTIONS OF GRAY MATTER ATROPHY IN ALZHEIMERS DISEASE BASED ON BASELINE FLORTAUCIPIR AND CONNECTOME-BASED ...
... to infer connectomes, or functional networks, from the corrected ROIs. Here, we apply the correction to simulated MEG ... Computer Simulation, Connectome, Data Interpretation, Statistical, Humans, Magnetoencephalography, Nerve Net, Signal Processing ... to infer connectomes, or functional networks, from the corrected ROIs. Here, we apply the correction to simulated MEG ...
microsculpted gold leaf painting of the Chaotic Connectome by Dr. Greg Dunn. ... Chaotic Connectome is the first microetching ever produced, and is of an abstract neural landscape. This piece was initially ... Chaotic Connectome is illuminated by three colors of light embedded within a custom shadowbox used to present the microetching ...
The model is based on Human Connectome and 7 Tesla Magnetic Resonance Imaging (MRI) data. We envision that the proposed virtual ... The model is based on Human Connectome and 7 Tesla Magnetic Resonance Imaging (MRI) data. We envision that the proposed virtual ... Psychiatry Neuroimaging Laboratory / Publications / Research Area / A Virtual Patient Simulator Based on Human Connectome and 7 ... A Virtual Patient Simulator Based on Human Connectome and 7 T MRI for Deep Brain Stimulation ...
... and functional connectome (derived from resting-state fMRI). However, most published connectome studies have focused on either ... With the advent of connectomics, the primary graphs or networks of interest are structural connectome (derived from DTI ... Title: Unified Embeddings of Structural and Functional Connectome via a Function-Constrained Structural Graph Variational Auto- ... capable of incorporating information from both functional and structural connectome in an unsupervised fashion. This leads to a ...
The Connectome: A Road Map to Brain Circuitry From Interactive Marketing & Web ... Bryan Jones, Ph.D., an investigator at the Moran Eye Center, talks about his research building a connectome of the retina. He ...
StarCluster and CPAC for Human Connectome. Leave a reply The Human Connectome Project aims to provide an unparalleled ... We got a chance to work with projects "Human Connectome" and we were using CPAC for processing datasets of Functional Magnetic ... The Configurable Pipeline for the Analysis of Connectomes (C-PAC) is an open-source software pipeline for automated ...
Nature: Connectomes make the map. October 2, 2015. This article in the journal Nature explains how the Developing Human ... The Developing Human Connectome Project is funded through a Synergy Grant by the European Research Council (ERC) under the ... Launch of iFIND and Connectome On 3rd February over 50 people gathered in the Central Hall at St Thomas Hospital for the ... Connectome Project (dHCP) will play a significant role in the future of neuroscience. The ground-breaking techniques developed ...
Building a Nanoscale Bushy Cell Connectome: Wiring Diagrams, Big Data Challenges and Hearing In Silico ... Building a Nanoscale Bushy Cell Connectome: Wiring Diagrams, Big Data Challenges and Hearing In Silico ...
Heritability of fractional anisotropy in human white matter: A comparison of Human Connectome Project and ENIGMA-DTI data. ...
The complete set of connections in the brain is called our connectome. Over the last 20 years we have found out more about how ... More information can also be found in my book Changing Connectomes (MIT Press, 2020; https://mitpress.mit.edu/changing- ... Event Link: https://www.eventbrite.co.uk/e/changing-connectomes-improving-brain-connectivity-tickets-371954795807 ...
Functional Connectome of the Fetal Brain. Turk E, van den Heuvel MI, Benders MJ, de Heus R, Franx A, Manning JH, Hect JL, ... The dutch connectome lab is a group of neuroscience enthusiasts with all kinds of backgrounds (biology, physics, math, medicine ... Linking connectomes from various modalities (EEG, resting state fMRI, DTI). *Studying different modalities of the developing ... Data as used in the paper "Edge-centric perspective on the human connectome: link communities in the brain", De Reus et al. ...
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  • This article in the journal Nature explains how the Developing Human Connectome Project (dHCP) will play a significant role in the future of neuroscience. (developingconnectome.org)
  • The Developing Human Connectome Project is funded through a Synergy Grant by the European Research Council (ERC) under the European Union's Seventh Framework Programme (FP/2007-2013) / ERC Grant Agreement n. 319456. (developingconnectome.org)
  • We have launched a new website for our Developing Human Connectome Project funded by an ERC Synergy Grant. (brain-development.org)
  • We found fMRI-BOLD partial correlation was altered at more edges as a function of the structural connectome (SC) damage, relative to the correlation. (mit.edu)
  • Partial correlation reflects structural connectome damage in 24% of edges tested. (mit.edu)
  • With the advent of connectomics, the primary graphs or networks of interest are structural connectome (derived from DTI tractography) and functional connectome (derived from resting-state fMRI). (arxiv.org)
  • However, most published connectome studies have focused on either structural or functional connectome, yet complementary information between them, when available in the same dataset, can be jointly leveraged to improve our understanding of the brain. (arxiv.org)
  • To this end, we propose a function-constrained structural graph variational autoencoder (FCS-GVAE) capable of incorporating information from both functional and structural connectome in an unsupervised fashion. (arxiv.org)
  • Purpose: To investigate the structural brain connectome in patients with Parkinson disease (PD) and mild cognitive impairment (MCI) and in patients with PD without MCI. (vumc.nl)
  • The individual structural brain connectome of 170 patients with PD (54 with MCI, 116 without MCI) and 41 healthy control subjects was obtained by using deterministic diffusion-tensor tractography. (vumc.nl)
  • Diffusion MRI reflects the random diffusion of water molecules, which is affected by the microscopic structure of tissue, here the human brain, enabling us to infer the microarchitecture of these tissues en term of local density and structural organization. (cnrs.fr)
  • In 2014 , we published a first article under the lead of Felix Blankenburg describing the effort of a first structural-functional MNI connectome . (netstim.org)
  • We will generate a structural connectome for quintessential Human Connectome Project subject 100307. (mrtrix.org)
  • Predicting sex, age, general cognition and mental health with machine learning on brain structural connectomes. (bvsalud.org)
  • We modelled N = 8183 structural connectomes from UK Biobank using six different structural network weightings obtained from diffusion MRI . (bvsalud.org)
  • This highlights that model complexity is unlikely to improve detection of associations between structural connectomes and complex phenotypes with the current sample size . (bvsalud.org)
  • Members of our centre at the UK DRI Connectome 2019. (kcl.ac.uk)
  • Our results show that rs-fMRI may be acquired in DBS ON and OFF conditions on clinical MRI hardware and that data is useful to gain additional insight into how DBS modulates the functional connectome of the human brain. (biorxiv.org)
  • The Configurable Pipeline for the Analysis of Connectomes (C-PAC) is an open-source software pipeline for automated preprocessing and analysis of resting-state fMRI data. (capsunlock.net)
  • We got a chance to work with projects " Human Connectome " and we were using CPAC for processing datasets of Functional Magnetic Resonance Imaging (fMRI). (capsunlock.net)
  • Combining connectome gradient and stepwise connectivity analysis based on task-free functional magnetic resonance imaging (fMRI), we demonstrated atypical connectivity transitions between sensory and higher-order default mode regions in a large cohort of individuals with autism relative to typically-developing controls. (combinelab.net)
  • This fMRI study aimed to construct a reliable prediction model of personality in a large sample by using connectome-based predictive modeling, a recently developed machine learning approach. (medscape.com)
  • Script to convert baby connectome project to BIDS? (neurostars.org)
  • I'm downloading the UNC/UMN Baby Connectome Project from the NDA and wondering if anyone has a script they'd be willing to share to convert dataset to BIDS? (neurostars.org)
  • The LifeSpan Baby Connectome Project (BCP) will explore human brain development from birth through early childhood, focusing on factors that contribute to healthy brain development. (neurostars.org)
  • The recently defined framework of the 'human connectome' allows to globally analyse parts of the brain and their interconnections. (biorxiv.org)
  • Now we investigate this on the largest available brain network, the $21.662$ node fruit-fly connectome, using the Kuramoto synchronization model. (arxiv.org)
  • The Human Connectome Project aims to provide an unparalleled compilation of neural data, an interface to graphically navigate this data and the opportunity to achieve never before realized conclusions about the living human brain. (capsunlock.net)
  • The complete set of connections in the brain is called our connectome. (nottingham.ac.uk)
  • When you start to explain how difficult it would be to find the connectome of an entire brain, people ask, 'What's the point? (wanderlustmind.org)
  • Fiber tracking using data from the Human Connectome Project has been conducted to elucidate the complex anatomy of the brain pathways. (labsolver.org)
  • The connectome allowed the researchers to analyze all the possible neural connections for every fruit fly brain cell. (medicalnewstoday.com)
  • Our project deals with this new framework of the modern neuroscience, the connectomics, which examines the anatomical organization and the functioning of the brain through the connectome to relate it with the cognitive functioning. (cnrs.fr)
  • If you happen to be interested in brain science then Sebastian Seung's Connectome is a book for you. (blogspot.com)
  • Reading Connectome may not be enough to turn one into a neurosurgeon, but it will certainly help readers to pick up some basic knowledge of how the brain works. (blogspot.com)
  • Based on diffusion-weighted or resting-state functional MRI data of large cohorts of subjects/patients, this line of work focused on running whole-brain tractography or functional connectivity analyses, warping individual connectomes into standard space and then averaging the results across the group of subjects. (netstim.org)
  • A second article published under the lead of Michael D Fox explored connectivity profiles of literature based deep brain stimulation targets using normative connectomes. (netstim.org)
  • Aerobic fitness explains individual differences in the functional brain connectome of healthy young adults. (illinois.edu)
  • Neuroanatomy content in the Central Nervous System tree [A08.186] was updated to reflect the current progress in neurobiomedical science and to accommodate search and retrieval of literature in brain connectome and related disciplines. (bvsalud.org)
  • SfN Global Connectome: A Virtual Event will be held January 11-13. (sfn.org)
  • The Human Connectome Project and Connectome Coordination Facility are funded by the National Institutes of Health, and all information in this site is available to the public domain. (humanconnectome.org)
  • The member universities of the Human Connectome Project take privacy very seriously, whether dealing with participant data or the data of those visiting this website. (humanconnectome.org)
  • The Northwestern University study draws on a 10-year project that produced the connectome , the first full map of neural pathways in an animal. (medicalnewstoday.com)
  • This novel connectome in use here was based on high-quality multishell diffusion data acquired within the human connectome project ( Setsompop 2013 ). (netstim.org)
  • This made use of a 1000-healthy subject functional connectome based on data off the Harvard genomic superstruct project that is also used on neurosynth.org and was both preprocessed and provided by Thomas Yeo ( Yeo 2011 ). (netstim.org)
  • Powered by a free Atlassian Confluence Open Source Project License granted to Human Connectome Project. (humanconnectome.org)
  • ConnectomeDB shares raw and preprocessed data from the Young Adult Human Connectome Project. (wustl.edu)
  • Seung explains how this new map of a human "connectome" might even enable us to "upload" our brains into a computer, making us effectively immortal. (kurzweilai.net)
  • Even more than our genome, our connectome shapes who we are, says Seung, who outlines his vision for connectome research in a new book, Connectome, published this month by Houghton Mifflin Harcourt. (wanderlustmind.org)
  • In 2017 , a first article under the lead of Andrea A Kühn made use of such normative connectomes by combining connectivity measures with electrophysiological recordings of the subcortex. (netstim.org)
  • Normative connectomes cannot replace patient/subject-specific connectivity information but are useful in scenarios where subject-specific data is not available and cannot be acquired. (netstim.org)
  • If researchers are interested in how connectivity was before the stroke event, normative connectomes may at least give a useful hint (e.g. (netstim.org)
  • Biomarkers were automatically extracted and used to generate time series for 27 regions of interest within the cartilage map to create a connectivity matrix (connectome). (ismrm.org)
  • Workbench Command is a set of command-line tools that can be used to perform simple and complex operations within Connectome Workbench. (humanconnectome.org)
  • Get Connectome Workbench! (humanconnectome.org)
  • Version 1.5.0 of the Connectome Workbench is now publicly available for download for Mac, Windows and Linux. (humanconnectome.org)
  • Connectome Workbench is the key visualization and analysis tool for 'HCP-style' studies. (wustl.edu)
  • We reconstructed a comprehensive connectome of the circuits of Drosophila 's motion-sensing T4 cells using a novel EM technique. (elifesciences.org)
  • Drosophila circuits underlying identified behaviors are being reconstructed in the pipeline with the goal of generating a complete Drosophila connectome. (janelia.org)
  • Atypical functional connectome hierarchy in autism", Nature Communications. (combinelab.net)
  • 2016 , we replicated results based on a much larger cohort of healthy subjects and validated the use of such normative connectomes by replicating multiple connectomic studies directly within template space and based on the group connectome only. (netstim.org)
  • Axons in the connectomes of the left and right interscutularis muscles of a 1-month old animal were color-coded based on the rank-order of their motor unit sizes (the number of muscle fibers innervated by each axon) in each connectome. (medicalxpress.com)
  • First, the connectome is principally about structure, about the extensive but finite set of physical links between the neurons, namely the axons. (cnrs.fr)
  • The dutch connectome lab is a group of neuroscience enthusiasts with all kinds of backgrounds (biology, physics, math, medicine, artificial intelligence) working at the Complex Trait Genetics Lab and the center for neurogenomics and cognitive research , part of the Neurocience Campus Amsterdam, VU Amsterdam and Amsterdam UMC. (dutchconnectomelab.nl)
  • Providing the Connectome Framework, we can allow anyone to create an instance of a connectome, connect sensory data to the instance and allow the user to define the output. (connectomeengine.com)
  • This complex wiring system, termed the connectome, reflects the necessary connective architecture for the neural dynamics that give rise to nearly all cognitive functions. (labsolver.org)
  • Comparison of each neuron and its counterpart on the opposite side of the animal revealed that each connectome was unique," Lichtman says, "demonstrating wiring diagrams that differ substantially in form, even within a common genetic background. (medicalxpress.com)
  • In this paper, the authors describe a connectome-based model that may effectively predict loneliness at the individual level. (medscape.com)
  • Our comprehensive connectome reveals complex circuits that include candidate anatomical substrates for both HR and BL types of motion detectors. (elifesciences.org)
  • The participant data from our research into the Human Connectome that is stored in our XNAT server is de-identified, and contains no personal health information (PHI). (humanconnectome.org)
  • The model is based on Human Connectome and 7 Tesla Magnetic Resonance Imaging (MRI) data. (harvard.edu)
  • There is a small additional article associated with the data release of this first connectome. (netstim.org)
  • The human connectome: a complex network. (bvsalud.org)
  • Saba L, Hoffman P, Tabakoff B. Using Baseline Transcriptional Connectomes in Rat to Identify Genetic Pathways Associated with Predisposition to Complex Traits. (ucdenver.edu)
  • Bryan Jones , Ph.D., an investigator at the Moran Eye Center, talks about his research building a connectome of the retina. (kaltura.com)
  • This process enables the straightforward application of network modelling methods, including partial correlation or multivariate autoregressive modelling, to infer connectomes, or functional networks, from the corrected ROIs. (ox.ac.uk)
  • Previous simulation studies on human connectomes suggested, that critical dynamics emerge subcrititcally in the so called Griffiths Phases. (arxiv.org)
  • Chaotic Connectome is the first microetching ever produced, and is of an abstract neural landscape. (gregadunn.com)
  • In order to understand how each nerve cell integrates into the functional organization of a neural circuit, it is necessary to obtain the complete wiring diagram (connectome) of the circuit by tracing out all the neural processes in the sample. (medicalxpress.com)
  • These first-ever mammalian "connectomes," or complete neural circuit diagrams, reveal that neural wiring can vary widely even in paired tissues on the left and right sides of the same animal. (medicalxpress.com)
  • A complete map of the cerebral connections, the connectome, is required for interpreting measurements of the signals transmitted between neurons. (cnrs.fr)
  • Curiously, the connectome of the mouse interscutularis -- a muscle also found in dogs, rats, and other mammals that readily move their ears -- reveals that some of its neurons are as much as 25 percent longer than is necessary. (medicalxpress.com)