Connective Tissue Diseases: A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.Mixed Connective Tissue Disease: A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.Connective Tissue: Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Raynaud Disease: An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.Collagen Diseases: Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Connective Tissue Growth Factor: A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.Autoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Skin and Connective Tissue Diseases: A collective term for diseases of the skin and its appendages and of connective tissue.Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.Lung Diseases, Interstitial: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.snRNP Core Proteins: The protein components that constitute the common core of small nuclear ribonucleoprotein particles. These proteins are commonly referred as Sm nuclear antigens due to their antigenic nature.CREST Syndrome: A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.Dermatomyositis: A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)Connective Tissue Cells: A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.Hypertension, Pulmonary: Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.Rheumatic Diseases: Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.Breast Implants: Implants used to reconstruct and/or cosmetically enhance the female breast. They have an outer shell or envelope of silicone elastomer and are filled with either saline or silicone gel. The outer shell may be either smooth or textured.Myositis: Inflammation of a muscle or muscle tissue.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Ribonucleoprotein, U1 Small Nuclear: A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U1 snRNP along with other small nuclear ribonucleoproteins (U2, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction.Autoantigens: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.Polymyositis: Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)Polyarteritis Nodosa: A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.Scleroderma, Localized: A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Mucinoses: Mucoid states characterized by the elevated deposition and accumulation of mucin (mucopolysaccharides) in dermal tissue. The fibroblasts are responsible for the production of acid mucopolysaccharides (GLYCOSAMINOGLYCANS) in the ground substance of the connective tissue system. When fibroblasts produce abnormally large quantities of mucopolysaccharides as hyaluronic acid, chondroitin sulfate, or heparin, they accumulate in large amounts in the dermis.Ribonucleoproteins, Small Nuclear: Highly conserved nuclear RNA-protein complexes that function in RNA processing in the nucleus, including pre-mRNA splicing and pre-mRNA 3'-end processing in the nucleoplasm, and pre-rRNA processing in the nucleolus (see RIBONUCLEOPROTEINS, SMALL NUCLEOLAR).Ribonucleoproteins: Complexes of RNA-binding proteins with ribonucleic acids (RNA).Vasculitis: Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.Nails: The thin, horny plates that cover the dorsal surfaces of the distal phalanges of the fingers and toes of primates.Silicones: A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)Idiopathic Interstitial Pneumonias: A group of interstitial lung diseases with no known etiology. There are several entities with varying patterns of inflammation and fibrosis. They are classified by their distinct clinical-radiological-pathological features and prognosis. They include IDIOPATHIC PULMONARY FIBROSIS; CRYPTOGENIC ORGANIZING PNEUMONIA; and others.Marfan Syndrome: An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.Microscopic Angioscopy: The noninvasive microscopic examination of the microcirculation, commonly done in the nailbed or conjunctiva. In addition to the capillaries themselves, observations can be made of passing blood cells or intravenously injected substances. This is not the same as endoscopic examination of blood vessels (ANGIOSCOPY).Toes: Any one of five terminal digits of the vertebrate FOOT.Surgery, Plastic: The branch of surgery concerned with restoration, reconstruction, or improvement of defective, damaged, or missing structures.Humerus: Bone in humans and primates extending from the SHOULDER JOINT to the ELBOW JOINT.ArthritisRNA, Small Cytoplasmic: Small RNAs found in the cytoplasm usually complexed with proteins in scRNPs (RIBONUCLEOPROTEINS, SMALL CYTOPLASMIC).Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Hydroxychloroquine: A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)Rheumatoid Nodule: Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.Pericardial Effusion: Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.Cranial Nerve Diseases: Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disorders of the brain stem nuclei from which the cranial nerves originate or terminate.Rheumatoid Factor: Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.DNA, Single-Stranded: A single chain of deoxyribonucleotides that occurs in some bacteria and viruses. It usually exists as a covalently closed circle.Microscopic Polyangiitis: A primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Cryptogenic Organizing Pneumonia: An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.Esophageal Motility Disorders: Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).Fingers: Four or five slender jointed digits in humans and primates, attached to each HAND.Scleritis: Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Eubacterium: A genus of gram-positive, rod-shaped bacteria found in cavities of man and animals, animal and plant products, infections of soft tissue, and soil. Some species may be pathogenic. No endospores are produced. The genus Eubacterium should not be confused with EUBACTERIA, one of the three domains of life.Nucleoproteins: Proteins conjugated with nucleic acids.Antibody Specificity: The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.Antigens, Nuclear: Immunologically detectable substances found in the CELL NUCLEUS.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Respiratory Function Tests: Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.Immediate-Early Proteins: Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Skin DiseasesBehcet Syndrome: Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.Cardiac Tamponade: Compression of the heart by accumulated fluid (PERICARDIAL EFFUSION) or blood (HEMOPERICARDIUM) in the PERICARDIUM surrounding the heart. The affected cardiac functions and CARDIAC OUTPUT can range from minimal to total hemodynamic collapse.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Intercellular Signaling Peptides and Proteins: Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.Immunoblotting: Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.Methylprednisolone: A PREDNISOLONE derivative with similar anti-inflammatory action.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Silicone breast implants: epidemiological evidence of sequelae. (1/463)

Skeptics may certainly find fault with the third study (the only one to report a significant finding) or with all or any of the statistics described. But few could argue, after examining these studies, that the relative risk for a known and well-defined connective tissue disease is likely greater than 2. Another possibility has been raised, one that calls to mind other difficult-to-study syndromes linked to exposures. In a study addressing Gulf War syndrome, signs and symptoms were often mentioned that proved difficult to describe systematically and therefore difficult to study. What if a suspected silicone exposure syndrome were so mild and transient that it did not warrant a physician visit (as in the Mayo Clinic study). receive a diagnosis (as in the Nurses' Health Study), or require admission to a hospital (as in the Danish and Swedish studies)? And if such a disorder were, in fact, mild and transient, should it merit the concern that has been shown and the compensation that has been awarded in the silicone implant litigation cases to date? We suggest that neither a well-described disorder with a relative risk of less than 2 nor a transient and mild disorder seems compatible with the number of litigants over silicone implants and the apparent seriousness of their complaints. Some 400,000 women joined in one class action suit for damages, and 170,000 joined in another. Even if there had been 2 million implants undertaken in the United States over the 3 decades in which implant surgery has been practiced (and some estimates put the number closer to 1 million), there is no conceivable way in which a relative risk of 2 or 3 (or even 4) for each of the rare syndromes reported could explain so many exposed women being affected. At most, 2200 out of 2 million unexposed women would be expected to have had any one of the listed forms of connective tissue disorders, most of which are very rare. Doubling the risk among the exposed population yields 4400, and increasing the risk 20-fold produces 44,000. At this rate, there is no way in which 400,000 litigants could all be affected. Extensions of the already-completed studies are ongoing, at least 1 of which is government funded; apparently it is thought in the United States (though not in the United Kingdom or elsewhere) that there is still room for reasonable doubt as to the supposed causal relationships. But if epidemiology is invoked in the interest of public health to prevent the many uses of silicone, the weight of the evidence abstracted here supports the inference that silicone breast implants have not been proved guilty of causing connective tissue disorders.  (+info)

Pulmonary artery pressure variation in patients with connective tissue disease: 24 hour ambulatory pulmonary artery pressure monitoring. (2/463)

BACKGROUND: The specific contribution of secondary pulmonary hypertension to the morbidity and mortality of patients with underlying lung disease can be difficult to assess from single measurements of pulmonary artery pressure. We have studied patients with secondary pulmonary hypertension using an ambulatory system for measuring continuous pulmonary artery pressure (PAP). We chose to study patients with connective tissue disease because they represent a group at high risk of pulmonary vascular disease, but with little disturbance of lung function. METHODS: Six patients (five with progressive systemic sclerosis and one with systemic lupus erythematosis) were studied. They underwent preliminary cardiopulmonary investigations followed by Doppler echocardiography, right heart catheterisation, and ambulatory pulmonary artery pressure monitoring to measure changes in pressure over a 24 hour period including during a formal exercise test. RESULTS: All patients had pulmonary hypertension as measured by Doppler echocardiography with estimated pulmonary artery systolic pressures of 40-100 mm Hg. Pulmonary function testing revealed virtually normal spirometric values (mean FEV1 86.9% predicted) but marked reduction in CO gas transfer factor (KCO 57.8% predicted). Exercise responses were impaired with mean VO2max 50.6% predicted. Ambulatory PAP monitoring indicated significant changes in pressures with variation in posture and activity throughout 24 hours. Resting PAP did not predict the change in PAP seen on exercise. CONCLUSION: Conventional methods of assessment of the pulmonary circulation based on single measurements in the supine position may underestimate the stresses faced by the right side of the circulation. This ambulatory system allows monitoring of pulmonary haemodynamics continuously over 24 hours during normal activities of daily living. These measurements may increase our understanding of the contribution made by secondary pulmonary hypertension to the morbidity and mortality of the underlying lung disease.  (+info)

Petroleum distillate solvents as risk factors for undifferentiated connective tissue disease (UCTD). (3/463)

Occupational solvent exposure may increase the risk of connective tissue disease (CTD). The objective of this case-control study was to investigate the relation between undifferentiated connective tissue disease (UCTD) and solvent exposure in Michigan and Ohio. Women were considered to have UCTD if they did not meet the American College of Rheumatology classification criteria for any CTD but had at least two documented signs, symptoms, or laboratory abnormalities suggestive of a CTD. Detailed information on solvent exposure was ascertained from 205 cases, diagnosed between 1980 and 1992, and 2,095 population-based controls. Age-adjusted odds ratios (OR) and 95 percent confidence intervals (CI) were calculated for all exposures. Among 16 self-reported occupational activities with potential solvent exposure, furniture refinishing (OR = 9.73, 95 percent CI 1.48-63.90), perfume, cosmetic, or drug manufacturing (OR = 7.71, 95 percent CI 2.24-26.56), rubber product manufacturing (OR = 4.70, 95 percent CI 1.75-12.61), work in a medical diagnostic or pathology laboratory (OR = 4.52, 95 percent CI 2.27-8.97), and painting or paint manufacturing (OR = 2.87, 95 percent CI 1.06-7.76) were significantly associated with UCTD. After expert review of self-reported exposure to ten specific solvents, paint thinners or removers (OR = 2.73, 95 percent CI 1.80-4.16) and mineral spirits (OR = 1.81, 95 percent CI 1.09-3.02) were associated with UCTD. These results suggest that exposure to petroleum distillates increases the risk of developing UCTD.  (+info)

Up-regulation of intercellular adhesion molecule-1 (ICAM-1), endothelial leucocyte adhesion molecule-1 (ELAM-1) and class II MHC molecules on pulmonary artery endothelial cells by antibodies against U1-ribonucleoprotein. (4/463)

In order to elucidate the pathogenic role(s) of autoantibodies in connective tissue disease (CTD), we examined whether autoantibodies against U1-ribonucleoprotein (RNP) and double-stranded (ds) DNA can up-regulate ICAM-1, ELAM-1 and class I and II MHC molecule expression on pulmonary artery endothelial cells (HPAEC). ICAM-1, ELAM-1 and class II MHC molecule expression on HPAEC cultured in the presence of anti-U1-RNP-containing and anti-dsDNA-containing IgG from CTD patients was up-regulated significantly in comparison with that on HPAEC cultured with IgG from normal healthy volunteers. Affinity chromatographic enrichment and depletion of the anti-U1-RNP antibody content of anti-U1-RNP-containing IgG confirmed that the anti-U1-RNP antibody did up-regulate ICAM-1, ELAM-1 and class II MHC molecule expression. The finding that an IgG F(ab')2-purified anti-U1-RNP antibody also up-regulated expression of these molecules may indicate that mechanisms other than Fc receptor-mediated stimulation are involved. These in vitro findings suggest that autoantibodies against U1-RNP and dsDNA play important roles in the immunopathological processes leading to the proliferative pulmonary arterial vasculopathy observed in CTD patients with pulmonary hypertension by up-regulating adhesion and class II MHC molecule expression on endothelial cells.  (+info)

T cell receptor beta-chain third complementarity-determining region gene usage is highly restricted among Sm-B autoantigen-specific human T cell clones derived from patients with connective tissue disease. (5/463)

OBJECTIVE: To determine the structure of T cell receptors (TCR) used by Sm-B-reactive human T cell clones, to map T cell epitopes on the Sm-B autoantigen, and to determine the HLA restriction element used in the recognition of Sm-B by T cells. METHODS: Sm-B-reactive T cell clones were generated from patients with connective tissue disease by using either a recombinant fusion protein or synthetic peptides. The TCR structure was defined with the use of polymerase chain reaction and DNA sequencing. Synthetic peptides were used to map T cell epitopes on Sm-B. HLA restriction element usage was defined by using monoclonal antibody blocking. RESULTS: Usage of the TCR third complementarity-determining region (CDR3) was highly restricted among Sm-B autoantigen-specific human T cell clones. Only amino acids 48-96 of the Sm-B2 autoantigen were recognized by T cells, and this occurred in the context of HLA-DR. CONCLUSION: TCR CDR3 gene usage is highly conserved by Sm-B autoantigen-specific T cell clones, and this appears to be related to the recognition of a limited number of T cell epitopes on the Sm-B autoantigen presented in the context of HLA-DR.  (+info)

Pneumocystis carinii pneumonia in patients with connective tissue diseases: the role of hospital experience in diagnosis and mortality. (6/463)

OBJECTIVE: Pneumonia due to Pneumocystis carinii has been increasingly reported in patients with connective tissue diseases, but the frequency of this complication is not known. We sought to determine the frequency of P carinii pneumonia (PCP) in patients with connective tissue diseases, and to determine the role that a hospital's acquired immunodeficiency syndrome (AIDS)-related experience may have in the diagnosis of PCP in these patients. METHODS: We used a state hospitalization registry to identify all patients with PCP and either rheumatoid arthritis, systemic lupus erythematosus, Wegener's granulomatosis, polymyositis, dermatomyositis, polyarteritis nodosa, or scleroderma who had an emergent or urgent hospitalization in California from 1983 to 1994. We compared patient and hospital characteristics between these patients and patients with connective tissue diseases hospitalized with other types of pneumonia. RESULTS: Two hundred twenty-three patients with connective tissue diseases were diagnosed with PCP in the 12-year study period. The frequency of PCP ranged from 89 cases/10,000 hospitalizations/year in patients with Wegener's granulomatosis to 2 cases/10,000 hospitalizations/year in patients with rheumatoid arthritis. Compared with 5,457 patients with connective tissue diseases and pneumonia due to other organisms, patients with PCP were more likely to be younger, to be male, to have private medical insurance, and to have systemic lupus erythematosus, Wegener's granulomatosis, inflammatory myopathy, or polyarteritis nodosa rather than rheumatoid arthritis, and were less likely to be African American. Hospital size, teaching status, urban/rural location, proportion of admissions due to AIDS or PCP, and proportion of patients with pneumonia undergoing bronchoscopy were each associated with the likelihood of diagnosis of PCP in univariate analyses, but only the number of patients with PCP being treated at a hospital (odds ratio [OR] 1.03 for each additional 10 cases/year, 95% confidence interval [95% CI] 1.01-1.05) was associated with the likelihood of diagnosis of PCP in multivariate analyses. Patients were also somewhat more likely to be diagnosed with PCP if there had previously been a case of PCP in a patient with a connective tissue disease at the same hospital (OR 135, 95% CI 0.98-1.85). In-hospital mortality was 45.7%, and was unrelated to hospital characteristics. CONCLUSION: PCP is an uncommon, but often fatal, occurrence in patients with connective tissue disease. A hospital's prior experience with patients with PCP is associated with the likelihood that this condition is diagnosed in patients with connective tissue diseases who present with pneumonia, suggesting that diagnostic suspicion is an important factor in the correct identification of affected patients.  (+info)

Joint hypermobility and genetic collagen disorders: are they related? (7/463)

The HDCTs constitute a heterogeneous group of rare genetically determined diseases, the best known of which are Ehlers-Danlos and Marfan syndromes and osteogenesis imperfecta. Hypermobility is a feature common to them all, but it is also a feature that is highly prevalent in the population at large. Symptomatic hypermobile subjects (whose symptoms are attributable to their hypermobility) are said to be suffering from the benign joint hypermobility syndrome, which has many features that overlap with the HDCTs. It is not yet known whether there is a variety of hypermobility (symptomatic or otherwise) that is not part of a connective tissue disorder.  (+info)

111Indium antimyosin antibody imaging of primary myocardial involvement in systemic diseases. (8/463)

OBJECTIVE: The diagnosis of primary myocardial involvement in systemic diseases is clinically relevant but difficult in the absence of specific criteria. Whatever the underlying disease, myocytes degeneration is observed during the active phase of myocardial damage. The aim of this study was to assess the diagnostic value of scintigraphic imaging with 111Indium antimyosin antibody (AM), a specific marker of the damaged myocyte, for ongoing myocardial damage related to systemic diseases. METHODS: 40 patients with histologically confirmed systemic diseases were studied. They were classified into two groups according to the presence (group 1, n = 30), or the absence (group 2, n = 10) of clinical, electrocardiographic (ECG) or echocardiographic signs suggestive of myocardial involvement. Planar and tomographic acquisitions were obtained 48 hours after injection of AM (90 MBq). Rest 201thallium (T1) scintigraphy was also performed to assess myocardial perfusion and scarring. Clinical, ECG, and echocardiographic +/- scintigraphic evaluations were repeated during follow up (17 +/- 19 months) in 36 of 40 patients. RESULTS: In group 1, 13 of 30 patients (43%) showed diffuse significant AM uptake throughout the left ventricle (LV), and no or mild T1 abnormality. Two of these were asymptomatic, four had normal ECG, and two had no clinical or echographic LV dysfunction. All patients in group 2 had negative AMA scintigraphy and normal T1 scintigraphy. During follow up of 12 AM positive patients, cardiac status improved after immunosuppressive treatment was intensified in nine cases, worsened in two cases, and remained stable in one. During follow up of 24 AM negative patients, cardiac status remained stable in 23 cases despite treatment not being increased in 20, including two patients with sequellary myocardial involvement. The last patient developed mild LV dysfunction after 36 months. CONCLUSION: AM scintigraphy allows detection of active myocardial damage related to systemic diseases, with increased specificity compared with conventional methods, and increased sensitivity in some cases. Further studies are needed to assess the potential value of AM scintigraphy as a therapeutic guide.  (+info)

*Connective tissue disease

A connective tissue disease is any disease that has the connective tissues of the body as a target of pathology. Connective ... Mixed connective tissue disease - Mixed connective-tissue disease (MCTD) is a disorder in which features of various connective- ... William C. Shiel Jr.,Connective Tissue Disease Bodolay E, Szegedi G (May 2009). "Undifferentiated connective tissue disease". ... Undifferentiated connective tissue disease (UCTD) is a disease in which the body mistakenly attacks its own tissues. It is ...

*Undifferentiated connective tissue disease

... (UCTD) is a disease in which the body mistakenly attacks its own tissues. It is ... Mixed connective tissue disease. In: George C. Tsokos. Modern Therapeutics in Rheumatic Diseases. Humana Press; 2002. doi: ... June 2011). "Undifferentiated connective tissue disease presenting with prevalent interstitial lung disease: Case report and ... August 2009). "Undifferentiated connective tissue disease: a seven-center cross-sectional study of 184 patients". 28 (8). ...

*Mixed connective tissue disease

"mixed connective tissue disease" at Dorland's Medical Dictionary "Mixed Connective Tissue Disease (MCTD): Autoimmune Disorders ... Mixed connective tissue disease (also known as Sharp's syndrome), commonly abbreviated as MCTD, is an autoimmune disease ... "Mixed connective tissue disease--an apparently distinct rheumatic disease syndrome associated with a specific antibody to an ... It is sometimes said to be the same as undifferentiated connective tissue disease, but other experts specifically reject this ...

*ICD-10 Chapter XIII: Diseases of the musculoskeletal system and connective tissue

Systemic involvement of connective tissue, unspecified (M36) Systemic disorders of connective tissue in diseases classified ... diseases of the musculoskeletal system and connective tissue WHO , International Classification of Diseases (ICD). ... Other overlap syndromes Mixed connective tissue disease (M35.2) Behçet's disease (M35.3) Polymyalgia rheumatica (M35.4) Diffuse ... Diseases of the musculoskeletal system and connective tissue. (M00) Pyogenic arthritis (M01) Direct infections of joint in ...

*List of ICD-9 codes 710-739: diseases of the musculoskeletal system and connective tissue

710) Diffuse diseases of connective tissue (710.0) Systemic lupus erythematosus (710.2) Sjögren's syndrome (710.3) ... Connective tissue disease, unspec. (711) Arthropathy associated with infections (712) Crystal arthropathies (712.1) ... Diseases of the musculoskeletal system and connective tissue. ... Other disorders of soft tissues (729.0) Rheumatism unspecified ... Degenerative disc disease, thoracic (722.52) Degenerative disc disease, lumbar (722.6) Degeneration of intervertebral disc, ...

*Raynaud syndrome

... rheumatoid arthritis Sjögren's syndrome dermatomyositis polymyositis mixed connective tissue disease cold agglutinin disease ... "Connective Tissue Diseases". Rheumatology. London: Manson Publishing. p. 117. ISBN 978-1-84076-173-3. Smith CR, Rodeheffer RJ ( ... Secondary Raynaud's can occur due to a connective tissue disorder, such as scleroderma or lupus, injuries to the hands, ... Secondary Raynaud's has a number of associations: Connective tissue disorders: scleroderma systemic lupus erythematosus ...

*Anti-nuclear antibody

In addition to SLE, these antibodies are highly associated with mixed connective tissue disease. Anti-nRNP antibodies recognise ... They are highly associated with polymyositis and dermatomyositis, and are rarely found in other connective tissue diseases. ... A significant number of patients are diagnosed as systemic lupus erythematosus or undifferentiated connective tissue disease ... Venables PJ (2006). "Mixed connective tissue disease". Lupus. 15 (3): 132-7. doi:10.1191/0961203306lu2283rr. PMID 16634365. ...

*Ribonucleoprotein

"Mixed Connective Tissue Disease (MCTD) , Cleveland Clinic". my.clevelandclinic.org. Retrieved 2016-11-07. Ribonucleoproteins at ... Anti-RNP antibodies are autoantibodies associated with mixed connective tissue disease and are also detected in nearly 40% of ... "RNA-binding proteins in human genetic disease". Trends in genetics: TIG. 24 (8): 416-425. doi:10.1016/j.tig.2008.05.004. ISSN ...

*Overlap syndrome

Examples of overlap syndromes include mixed connective tissue disease and scleromyositis. Diagnosis depends on which diseases ... An overlap syndrome is an autoimmune disease of connective tissue in which a person presents with symptoms of two or more ... Autoimmune Mixed connective tissue disease The Myositis Association Overlap Syndrome 2011 Conference Presentation Maddison PJ ... 1991). "Overlap syndromes and mixed connective tissue disease". Current Opinion in Rheumatology. 3 (6): 995-1000. doi:10.1097/ ...

*Immunoadsorption

Hohenstein, B.; Bornstein, S.R.; Aringer, M. (2013). "Immunoadsorption for connective tissue disease". Atherosclerosis ... "Highly efficient removal of antibodies in diseases with impaired immune response". Fresenius. HW Jr Snyder; Cochran, SK; Balint ...

*Cocaine

Trozak D, Gould W (1984). "Cocaine abuse and connective tissue disease". J Am Acad Dermatol. 10 (3): 525. doi:10.1016/S0190- ... Cocaine may also greatly increase this risk of developing rare autoimmune or connective tissue diseases such as lupus, ... Moore PM, Richardson B (1998). "Neurology of the vasculitides and connective tissue diseases". J. Neurol. Neurosurg. Psychiatry ... It can also cause a wide array of kidney diseases and kidney failure. Cocaine use leads to an increased risk of hemorrhagic and ...

*Stimulant

Trozak D, Gould W (1984). "Cocaine abuse and connective tissue disease". J Am Acad Dermatol. 10 (3): 525. doi:10.1016/S0190- ... Moore PM, Richardson B (1998). "Neurology of the vasculitides and connective tissue diseases". J. Neurol. Neurosurg. Psychiatry ... and pathological restricting of lung tissue. Cocaine may also increase risk for autoimmune disease and damage nasal cartilage. ... Moderate coffee consumption may decrease the risk of cardiovascular disease, and it may somewhat reduce the risk of type 2 ...

*Braverman's sign

They may be associated with connective tissue diseases. Braverman IM. Skin signs of systemic disease. New York: Elsevier; 2008 ... ISBN 9780721637457 Patel LM, Lambert PJ, Gagna CE, Maghari A, Lambert WC (2011). "Cutaneous signs of systemic disease". Clin. ...

*Achard syndrome

Parish JG (1967). "Skeletal hand charts in inherited connective tissue disease". J Med Genet. 4 (4): 227-38. doi:10.1136/jmg. ...

*Aortic valve repair

50mm and connective tissue disease Ascending aortic aneurysm > 50mm and risk factors and connective tissue disease The goal of ... Cusp tissue is resected of detached where it is grossly abnormal. Using patch tissue the cusps are enlarged so they reach the ... Tissue of the aortic valve is removed or detached from the aorta in places where it is clearly abnormal. The location of a ... Tissue redundancy through stretching is corrected by sutures. A) Key problem The unicuspid aortic valve may not only result in ...

*Poco Bueno

An inherited connective tissue disease in the horse. Kadash, Kathy "Poco Bueno: Preserving the Past for the Future" Western ... Poco Bueno is the stallion that is linked to the genetic disease Hereditary Equine Regional Dermal Asthenia (HERDA) in stock ...

*Pulmonary hemorrhage

Common causes include autoimmune diseases and connective tissue diseases. Hemoptysis Pulmonary Hemorrhage Intensive Care ...

*Disseminated disease

The term may sometimes also characterize connective tissue disease. A disseminated infection, for example, has extended beyond ... Disseminated disease refers to a diffuse disease-process, generally either infectious or neoplastic. ...

*Gastric antral vascular ectasia

A connective tissue disease has been suspected in some cases. Autoimmunity may have something to do with it, as 25% of all ... Watermelon disease was first diagnosed by Wheeler et al. in 1979, and definitively described in four living patients by Jabbari ... Some of the discussed modalities have been used in GAVE patients with another underlying disease rather than SSc; they are ... The Genetic and Rare Diseases Information Center (GARD) states that pernicious anemia is one of the conditions associated with ...

*SnRNP70

Antibodies towards snRNP70 are associated with mixed connective tissue disease. GRCh38: Ensembl release 89: ENSG00000104852 - ... are associated with central neuropsychiatric manifestations in systemic lupus erythematosus and mixed connective tissue disease ...

*Myofascial pain syndrome

Some systemic diseases, such as connective tissue disease, can cause MPS. Poor posture and emotional disturbance might also ... Myofascial pain is pain in muscles or fascia (a type of connective tissue that surrounds muscles). It can occur in distinct, ... connective tissue) constrictions. It can appear in any body part. Characteristic features of a myofascial trigger points ...

*Anti-nRNP

Anti-snRNP70 antibodies can be elevated in mixed connective tissue disease. Migliorini P, Baldini C, Rocchi V, Bombardieri S ( ...

*The Marfan Foundation

Marfan syndrome Connective tissue disease "Charity Navigator Rating - The Marfan Foundation". Charity Navigator. Retrieved 2014 ... of saving lives and improving the quality of life for people affected by the condition which is a genetic connective tissue ...

*Collagen disease

Collagenopathy, types II and XI Connective tissue disease Coburn, Alvin (1974). Commitment Total. United States of America: ... which is a component of the connective tissue. The term "collagen disease" was coined by Dr. Alvin F. Coburn in 1932, on his ... Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus ... ISBN 0-8027-0449-2. Collagen disease entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public ...

*Dermatopolymyositis

Tymms KE, Webb J (December 1985). "Dermatopolymyositis and other connective tissue diseases: a review of 105 cases". J. ...

*Skin and skin structure infection

... is an infection of skin and associated soft tissues (such as loose connective tissue and mucous membranes). The pathogen ... The Infectious Diseases Society of America (IDSA) has retained the term "skin and soft tissue infection". List of cutaneous ... "Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases ... A skin and skin structure infection (SSSI), also referred to as skin and soft tissue infection (SSTI) or acute bacterial skin ...
P1: Possibility when comparing CTD-ILD group and UCTD-ILD group. P2: Possibility when comparing CTD-ILD group and IPF group. P3: Possibility when comparing UCTD-ILD group and IPF group ...
There are complex interactions between connective tissue disease (CTD) and interstitial lung disease (ILD), particularly in the PH patient. Clinicians that care for these patients will benefit from a deeper understanding of CTD and the ILD aspects of this diverse spectrum of disease. There are many clinical dilemmas to address and this course will focus on an approach to the evaluation and management of CTD-associated ILD.
(Update) Donna C: Undifferentiated Connective Tissue Disease (UCTD) For the most part I have still been doing very good. Some little setbacks here and there...
Objective. To review the diagnoses after 5 years in patients who were identified within 12 months of the onset of well established and undifferentiated connective tissue diseases CTD ; to examine death rates and disease remissions in these patients. Methods. This inception cohort of 410 patients was identified in 10 academic rheumatology...
Undifferentiated Connective Tissue Disease stories from our community of patients. Read how these patients from all walks of life got back into their game of life.
Objective: To investigate the timing and complications of lung transplantation for the treatment of connective tissue disease-associated interstitial lung disease (CTD-ILD). Method: The clinical data of connective tissue-associated disease lung transplantation recipients from September, 2015 to February, 2017 were collected. Results: 11 patients with CTD-ILD were evaluated by lung transplantation and were treated with lung transplantation. Including 2 cases dermatomyositis/polymyositis and interstitial lung disease (PM/DM-ILD), 4 cases rheumatoid arthritis and interstitial lung disease (RA-ILD), 4 cases of primary Sjgrens syndrome and interstitial lung disease (pSS-ILD), 1 case of systemic sclerosis and interstitial lung disease (SSc-ILD ...
Dr. Antin-Ozerkis received her Bachelors degree from Princeton University. She went on to complete her medical degree, residency, and fellowship in Pulmonary and Critical Care Medicine at the University of Pennsylvania, where she pursued advanced fellowship training in the evaluation and management of advanced lung disease and lung transplant patients. She came to Yale in 2006. Dr. Antin-Ozerkis is Medical Director of the Yale Interstitial Lung Disease Center of Excellence. Her specific area of clinical expertise is the diagnosis and treatment of interstitial lung diseases (ILD), with a focus on idiopathic pulmonary fibrosis (IPF) and connective tissue disease-associated interstitial lung disease (CTD-ILD). She leads a multidisciplinary group which meets weekly to review patient cases, offering consensus opinions on diagnosis and management. As part of a comprehensive approach to patient care, Yale ILD offers clinical drug trials for patients with IPF and other forms of pulmonary fibrosis. Dr. ...
ICD M30-M36 Systemic connective tissue disorders  autoimmune disease NOS collagen (vascular) disease NOS systemic autoimmune disease systemic collagen
Trigeminal neuralgia - Connective tissue disease Factor. Last reviewed for CCPS 10 March 1995.. Preliminary questions [8154]. 8603 [1] there is some evidence that a connective tissue disease may be a factor in the development of the condition under consideration.. 8184 - the veteran has suffered from a connective tissue disease at some time.. 6563 [2] the veteran has had scleroderma at some time.. or. 8615 [3] the veteran has had Sjogrens syndrome at some time.. or. 2576 [4] the veteran has had systemic lupus erythematosus at some time.. or. [5]8616. the veteran has had dermatomyositis at some time.. or. 8617 [6] the veteran has had mixed connective tissue disease at some time.. 8186 [7] the veteran suffered from the identified illness or injury, a connective tissue disease, prior to the clinical onset of trigeminal neuralgia. [8]. 8187 - the veteran has established the causal connection between the identified illness or injury, a connective tissue disease, and operational service for the ...
This week, I was called to evaluate a young man with several aneurysms (ballooning of his blood vessels) and a dilated (widened) aorta. The medical team thought he had a "connective tissue disease" because a family member also had a connective tissue disease-she had lupus. Unfortunately, doctors can mean very different things when they talk about a "connective tissue disease;" this is a common source of confusion for doctors and patients alike. After reading this post, I hope youll be able understand the difference.. Connective tissue is the "stuff" that holds your body together. That is, the bones, ligaments, tendons, cartilage, fat, and "glue" that keeps all your organs in place. Two very different types of diseases can affect these tissues-you can have problems in MAKING the connective tissues, or these tissues can be ATTACKED by the bodys own immune system.. In the first type of "connective tissue disease," the body is unable to produce strong connective tissues. Its like trying to build ...
Complex Treatment of Children Affected by Undifferentiated Connective Tissue Dysplasia Combined with Bone Mineral Density Reduction
Complex Treatment of Children Affected by Undifferentiated Connective Tissue Dysplasia Combined with Bone Mineral Density Reduction
The conceptual study of connective tissue diseases as one of causative factors in Interstitial lung diseases (ILDs) : both modern and ayurveda perspective ;patients with ILDs come with the onset of progressive exertional dyspnea or a persistent nonproductive cough. Hemoptysis , wheezing and chest pain may be present. Often , the identification of interstitial opacities on chest X-ray focuses the diagnostic approach on one of the ILDs. Rheumatoid arthritis is one of connective and autoimmune diseases which cause ILDs.. inflammation in the air space and alveolar walls and interstitial fibrosis are present due to autoimmunity.. the presence of jts pain , stiffness and deformity like swan neck etc with +ve antinuclear antibodies and anti- immunoglobulin antibodies ( RA factors ) confirm the diagnosis , however these tests are +ve even in absence of defined connective tissue diseases. ILDs are characterized as a significant part of a multiorgan process , as may occur in the connective tissue diseases ...
A total of 187 specimens from 142 subjects with rheumatoid arthritis, systemic lupus erythematosus, other connective tissue diseases, and controls were placed in cell culture. Specimens from 119 of the subjects grew, lasting over 2 yr in several instances. No evidence of virus infection has been found by a variety of sensitive methods, including cell fusion. Other approaches have likewise failed thus far to implicate any virus in the pathogenesis of rheumatoid arthritis.. ...
Connective tissue diseases by Graham R. V. Hughes; 4 editions; First published in 1977; Subjects: Collagen diseases, Connective Tissue Diseases, Connective Tissue, Diseases, Connective tissues, Internet Archive Wishlist
TY - JOUR. T1 - The short-term role of corticosteroid therapy for pulmonary arterial hypertension associated with connective tissue diseases. T2 - Report of five cases and a literature review. AU - Kato, M.. AU - Kataoka, H.. AU - Odani, T.. AU - Fujieda, Y.. AU - Otomo, Kotaro. AU - Oku, K.. AU - Horita, T.. AU - Yasuda, S.. AU - Atsumi, T.. AU - Ohira, H.. AU - Tsujino, I.. AU - Nishimura, M.. AU - Koike, T.. PY - 2011/10/1. Y1 - 2011/10/1. N2 - Pulmonary arterial hypertension (PAH) is a life-threatening complication in connective tissue diseases (CTD). It remains controversial whether immunosuppressive therapy is useful for PAH associated with CTD (PAH-CTD). The Dana Point algorithm does not refer such treatments in patients with PAH-CTD due to the lack of evidence. However, some case reports have shown the potential efficacy of immunosuppression for PAH-CTD. Here we report five cases of PAH-CTD treated with corticosteroids and discuss the current management of PAH-CTD with immunosuppressive ...
Aortic stenosis, hypertrophic obstructive cardiomyopathy, cerebrovascular and cardiovascular diseases (including cerebrovascular insufficiency, coronary heart disease, coronary insufficiency - a risk of excessive blood pressure lowering and concomitant ischemia). Severe autoimmune systemic connective tissue disease (including systemic lupus erythematosus, scleroderma), inhibition of bone marrow hematopoiesis in patients receiving immunosuppressive drugs (increasing the likelihood of neutropenia). Renovascular • Read More ». ...
Results 215 pregnancies in 184 women were included and classified according to mothers autoimmune disease: 52 (24,2%) Primary Antiphospholipid Syndrome (PAPS), 26 (12,1%) with only Antiphospholipid Antibodies (APA), 27 (12,6%) Systemic Erythematosus Lupus (SLE), 28 (13%) SLE with APA, 44 (20,5%) Undifferentiated Connective Tissue Disease (UCTD) and 38 (17,7%) UCTD with APA. A total of 41 (19,06%) miscarriages were reported, 32 (14,8%) in the first 10 weeks of pregnancy and 9 (4.18%) beyond that 10th week. Risk factors for miscarriages in the univariate analysis were mothers age, lupus anticoagulant, IgG and IgM anticardiolipin antibodies, previous miscarriages and PAPS, while UCTD was a protective factor. In the multivariate model only mothers age (OR 0.9, IC 95% 0.8-0.98), lupus anticoagulant (OR 2.5, IC 95% 1.1-5.4), IgG anticardiolipin (OR 4.0, IC 95% 1.8-9.0) and previous miscarriages (OR 2.8, IC 95% 1.2-6.5) were predictors. A Miscarriage Risk Score ranging between 0 and 11 points was ...
I lost my Mariel to Interstitial Lung Disease caused by Undifferentiated Connective Tissue Disease. Barely six weeks after we checked with a dermatologist to complain about some ordinary rashes and fever. ( We were even discharged earlier at another hospital for what they thought was merely a viral infection, after ruling out Dengue ). C3…
This multicenter study will attempt to determine the epidemiologic, clinical, serologic and immunogenetic factors associated with patients who develop scleroderma/systemic sclerosis after silicone prosthesis implantation or silicone injection. This will be accomplished by comparing these patients to groups of appropriately matched patients with idiopathic scleroderma/systemic sclerosis without silicone exposure, and appropriately matched volunteers who have received similar silicone implants or injections and have not developed symptoms, physical examination findings, or laboratory abnormalities associated with autoimmune/connective tissue diseases. Patient and physician questionnaires will be self-administered, and will collect data regarding: the number and types of implanted silicone devices or injections; the indications for and nature of the surgical procedures; peri- and post-operative complications; initial and subsequent clinical presentations; and therapy and clinical course of the ...
Hello, I havent posted in a long time - my official diagnosis is undifferentiated connective tissue disease with signed of lupus and Sjögrens syndrome. My last rheumatology check up was almost a...
She has masters degrees in applied, clinical early signs of pregnancy in my dog community ssigns. i want to bookmark everything you ever write. Be sure your schedule is coordinated with other teachers in the school. But the real trouble do a force much larger than they are-one which they cant even pinpoint, and so have little chance to fight. Your babys size may make you feel uncomfortable. Then they were born and their parents wouldnt let you. Plan for some decompression time between conferences. A doctor can sgns you from this requirement. One question that single parents often have is how to make quality time for their children, despite their exhaustion. O quality of education. A recent Consumers Research magazine report on the risk to health from some fluorescent lamps suggested new probes by industry and the government. Your tips are super helpful, thank you. In case undifferentiated connective tissue disease and pregnancy are on the look-out for schools in Punjabi Bagh from the best ...
Background Pulmonary hypertension (PH) can develop in connective tissue disease associated interstitial lung disease (CTD-ILD), and contributes to increased morbidity and mortality. However, except...
Rodriguez et al were the first to report autoantibodies directed against the Golgi complex identified in the serum of a patient with Sjögrens syndrome (SS).1 Since then, several isolated reports have described the presence of anti-Golgi antibodies (AGAs) in several connective tissue diseases (CTDs).1-7 In addition, immunoblotting and immunoprecipitation studies have suggested that there are at least 14 different Golgi complex autoantigens, and their molecular masses range from 35 to 260 kDa.5 However, few reports describe the association between the clinical features of CTD and AGAs. In this letter we present a case of rheumatoid arthritis (RA) associated with AGAs and review several reported cases.. The patient was a woman born in 1939 who developed seropositive RA in 1990. She was admitted to our hospital in March 1998 because of high grade fever, cough, sore throat, chest pain, and severe arthralgia. Systemic laboratory examination disclosed no antinuclear antibody, anti-DNA antibody, or ...
To determine the clinical significance of anticentromere (ACA) and anti Scl-70 antibodies in an English population with connective tissue diseases, we examined the sera of 150 patients, including 40...
Background Interstitial pneumonia in connective tissue diseases (CTD-IP) featuring inflammation and fibrosis is usually a leading cause of death in CTD-IP individuals. by histology, circulation cytometry and molecular biology. Capital t cell subsets included in the procedure of CTD-IP had been described, while the regulatory features of MSCs separated from the bone tissue marrow of regular people (HBMSCs) on cytotoxic Capital t cells and CTD-UIP HLFs had been looked into in vitro. Outcomes Higher frequencies of cytotoxic Capital t cells had been noticed in the lung and peripheral bloodstream of CTD-IP individuals, followed with a decreased regulatory Capital t cell (Treg) level. CTD-UIP HLFs secreted proinflammatory cytokines in mixture with upregulation of -clean muscle mass actin (-SMA). The addition of HBMSCs in vitro improved Tregs SC-514 concomitant with decreased cytotoxic Capital t cells in an fresh cell model with prominent cytotoxic Capital t cells, and advertised Tregs growth in ...
Background: Connective tissue disease (CTD) is a group of inflammatory disorders of unknown aetiology. Patients with CID often report hypersensitivity to nickel. We examined the frequency of delayed type hypersensitivity (DTH) (Type IV allergy) to metals in patients with CTD. Methods: Thirty-eight patients; 9 with systemic lupus erythematosus (SLE), 16 with rheumatoid arthritis (RA), and 13 with Sjogrens syndrome (SS) and a control group of 43 healthy age- and sex-matched subjects were included in the study. A detailed metal exposure history was collected by questionnaire. Metal hypersensitivity was evaluated using the optimised lymphocyte transformation test LTT-MELISA (R) (Memory Lymphocyte Immuno Stimulation Assay). Results: In all subjects, the main source of metal exposure was dental metal restorations. The majority of patients (87%) had a positive lymphocyte reaction to at least one metal and 63% reacted to two or more metals tested. Within the control group, 43% of healthy subjects ...
This article reviews the associations of occupational and environmental exposures relevant to connective tissue diseases, and in particular systemic sclerosis.
This article will inform you about lupus and connective tissue disease as well as other similar disorders that are interconnected with the disease.
Get to know the muscle and connective tissue diseases and learn more about lipoma, fibroids and duchenne muscular dystrophy. Epidemiology and clinical presentation of soft tissue pathology ✓, treatment of primary systemic amyloidosis ✓, myoma and myosarcoma ✓. Read more here!
University of Minnesota Health physicians are available to help you with some of the most advanced treatments to relieve pain from connective tissue disease and improve your quality of life.
A Herculean process really and you need to be applauded for locating something that mixes the three issues together in one go. Every cell in the body needs iodine. Unlike hierarchical data structure that require specific entrance points to find records in a hierarchy, network data structures can by entered and traversed more flexibly. I like to recommend counting calories and holding a diet journal at the least as soon as in your life for a minimum of 4-12 consecutive weeks or till you obtain unconscious competence. This way you will be able to determine what you are giving your pet. Foodstuffs that are rich in soluble fibres embrace seasonal fruits, beans, lentils, oat bran, dried peas, leafy greens connective tissue disease and nutrition barley. What should you eat and drink to produce enough milk and to get enough nutrients for your baby and yourself. We love using spinach as a base for a salad, and youll reap the greatest dietary advantages when its raw. By comparing the prices you could ...
Study Connective Tissue Disease flashcards from Rebecca Thomas's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
In an effort to understand the reasons behind people of any age, including children, being struck down with Rheumatoid Arthritis (RA) and other connective tissue diseases, we have delved and found some valuable and exciting conventional medical research.. The book The New Arthritis Breakthrough chronicles some 50 years of research and successful treatment of over 10,000 patients by the eminent US doctor Thomas McPherson Brown. It cites clinical trials that have repeatedly shown the link between bacteria and the inflammatory process that causes RA and other connective tissue diseases. Trial results show how these debilitating conditions are responsive to low dose antibiotic therapy. Patient reports in the book tell how antibiotic therapy has allowed them to discontinue cortisone, anti inflammatories and immuno-suppressant medications and regain a normal life after years of pain, debility, surgery, unemployment and untold difficulty.. In addition to results that are thought impossible for ...
For Patients: Helpful Information For Patients, The CTD-ILD Program is an integrative, patient-oriented program, which affords patients with CTD-ILD the opportunity receive comprehensive and coordinated care by experts in CTD-ILD
Rheumatoid arthritis is a connective tissue disorder which manifests in various clinical presentations. Before anything is discussed about it, we ought to know what a connective tissue disorder is
Connective tissue is the material that supports the organs in your body. It gives your tissues shape and strength. There are over 200 disorders that affect connective tissue. Together, they are known as connective tissue disorders, or CTDs.
This sounds as if you were born with an auto-immune (self attacking self) connective tissue disease. Connective tissue is what holds your cells together, and there are a few connective tissue diseases. In my family, we get red, inflammed connective tissue and like you, it hurts to lay or sit or get touched or anything. I was born with it, it is genetic. I would suggest that you research connective tissue diseases or find a specialist and a good teaching hospital (like a university medical center) that would be willing to do the work and tests for you. Bless you, what a life that is. ...
Heritable disorders of connective tissue are a heterogenous group of genetic conditions caused by defects of extracellular matrix elements such as collagen, elastin, mucopolysaccharides or related biomolecules. The genetic cause of many connective tissue disorders has been elucidated, while others are yet to be discovered or further defined. While clinical diagnostic criteria have been established for several of the connective tissue syndromes, many share features that overlap the known descriptions of other connective tissue disorders. Therefore, further characterization and phenotype/genotype correlation is needed to adequately diagnose and find treatments for these yet-to-be genotyped disorders.. An aim of this work is the examination of the cardiovascular, musculoskeletal and neurological complications of heritable connective tissue disorders (HDCT) and the natural history of these complications. Through mutational analysis for genes known to cause the HDCT, as well as identification of new ...
Modern Topics in Rheumatology. Hughes GRV 1976. (Heinemann). ISBN: 0-433-15560-4. Connective Tissue Disease. Hughes GRV 1977. Blackwell Scientific Publications. 4 Editions (including Spanish edition). ISBN: 0-632-00821-0. Systemic Lupus Erythematosus. Hughes GRV 1982. WB Saunders (In: Clinics in the Rheumatic Diseases). ISBN: 0307-742X. Lecture Notes in Rheumatology. Edmonds J & Hughes GRV 1986. Blackwells Scientific Publications. ISBN: (Out of print). Phospholipid-binding antibodies. Harris EN, Exner T, Hughes GRV 1991. CRC Press. ISBN: 0-8493-5536-2. Autoimmune Connective Tissue Diseases. Khamashta MA, Font J, Hughes GRV 1993. Doyma SA. Understanding Lupus. Hughes GRV 1996. Julia Schofield Consultants Ltd. ISBN: 1-901298-00-0. Hughes Syndrome : A Patients Guide to the Anti-phospholipid Syndrome. Hughes GRV 1997. Adrian Press Ltd, Ilford, Essex. Available from Lupus UK. Lupus. The Facts. Hughes GRV 2000. Oxford University Press. ISBN: 0-19-163145-4. Hughes Syndrome. A patients Guide. Hughes ...
Expert Team: Our team includes pulmonologists, rheumatologists, radiologists, pathologists, statisticians, nurses and staff members, who are all dedicated to improving your health care.
Connective Tissue Disorders: If you have a CTD such as Lupus, Rheumatoid Arthritis, Sjogrens or MCTD you may qualify for long term disability (LTD) benefits
Learn about Musculoskeletal and Connective Tissue Disorders symptoms, diagnosis and treatment in the Merck Manual. HCP and Vet versions too!
Welcome to the video course on Musculoskeletal and Connective Tissue Disorders. This self-study video course will help you hone your clinical and disease…
A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides ...
Systemic Lupus Erythematosus (SLE) is an immunologically mediated disease occurring most frequently in a female population of child-bearing age with target organs potentially in any body system. Several recent publications have brought to attention the fact that the fetus of a mother with systemic lupus erythematosus is also at risk to develop complications of its mothers disease. Most offspring of the mothers are normal, but transient as well as permanent residua have been observed, including the well-recognized phenomenon of discoid rash, leukopenia, thrombocytopenia, and Coombs-positive hemolytic anemia with LE cells and antinuclear antibodies. These transient phenomena occur at or soon ...
The present study shows that survival in patients with PAH is influenced by several factors. Although highly relevant baseline clinical characteristics are strong determinants of outcome, estimation of survival is also subject to several biases, including presence of associated conditions and interval from diagnosis to study enrolment. This strongly suggests that analysis of incident cohorts of homogeneous PAH populations should be recommended in future survival studies.. As previously described, associated conditions may dramatically influence survival rates in PAH cohorts 5-14. Our results confirm that patients with PAH complicating the course of congenital heart disease are more likely to survive to 3 yrs compared to patients that develop PAH in the setting of connective tissue diseases, such as systemic sclerosis, despite similar management approaches 5, 9, 10. Therefore, we recommend that PAH cases with associated conditions (e.g. connective tissue disease, portal hypertension, HIV ...
Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.
Case 2 had a number of features which are more closely associated with SLE. Firstly, there was a history of sun exposure. In this context, it is noteworthy that anti-Ro and anti-La antibodies, which were positive in this patient, are particularly associated with photosensitivity (Sontheimer et al. 1979). One model of the pathogenesis of photosensitivity in SLE proposes that exposure of keratinocytes to ultraviolet light increases the surface expression of Ro antigen. Anti-Ro antibodies would then bind these receptors and precipitate a cutaneous reaction which then begets a systemic reaction (Furukawa et al. 1999). It is tempting to speculate that such a mechanism may have triggered the final illness in Case 2, but this cannot be known for certain. This case showed vascular thrombosis in the affected lymph nodes, a feature which is seen in SLE.. Case 2 also showed focal evidence of haemophagocytosis in the lymph nodes. This was an interesting observation, but one whose significance is uncertain. ...
Diseases of the lung are classified as obstructive lung diseases like chronic obstructive pulmonary disease or cystic fibrosis, and restrictive lung diseases.
Welcome to the Rheumatology Department at North Devon District Hospital. We provide high quality care to patients with connective tissue diseases such as rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis and many more.. We are a multidisciplinary team comprising of two rheumatology consultants and four clinical nurse specialists, as well as physiotherapists, occupational therapists and many other staff who support the department (around 20 staff in all).. We treat over 3000 patients across the North Devon area with connective tissue diseases. We run clinics in North Devon District Hospital as well as satellite community clinics in Bideford and South Molton.. Use the links on the left to find out more about the services we offer or access patient information about conditions and medications.. ...
Major research interests of the centre focus on understanding the molecular and cell biology of connective tissue diseases, including tissue repair and remodeling processes, degenerative joint disease (osteoarthritis), and the genetic and molecular mechanisms underlying tissue scarring and replacement fibrosis (scleroderma). We pioneered the development and use of in vivo systems of human disease (transgenic and genetically modified conventional and conditional knock-out mice) as pre-clinical models to investigate disease pathogenesis and also discovery and validation programmes.. Our research programme uses tissue biopsies and in vitro systems to investigate critical mechanisms of disease pathogenesis, utilising control and patient-derived tissues and cells and in vivo models. Key regulatory pathways are examined, leading to a better understanding of disease pathogenesis, and improved management and treatment of connective tissue diseases ...
Low magnesium levels are often found in people with type 1 diabetes. skin and soft tissue infection Prevalence of Osteomyelitis in Diabetic Foot Ulcers et al. Diabetes And Zika Virus Arriva Medical Care Club bronze Diabetes However detail diabetes is not promptly treated it extends to the next phase.. About Chris; Media ; Clinic ; Contact; Connect. Data from two national surveys indicate that 28 % of individuals with diabetes were overweight and 59 % were obese.1 Furthermore a rise in body mass index (BMI) Connective tissue diseases Psoriatic Arthritis Gout It has a high association with other disorders such as diabetes Diabetes And Zika Virus Arriva Medical Care Club Connective tissue diseases Hypothyroidism Diabetes ::The 3 Step Trick that Reverses Diabetes Permanently in As Little as 11 Days.[ HYPOTHYROIDISM DIABETES ] The REAL cause of Diabetes Overview; Surgical Assistant; Physician Assistant; Athletic You can verify the license/certificate below. Diabetes Care Recognition Diabetes Diet ...
Many family members, friends and neighbours do not recognise themselves as carers because they see their role as being a spouse, partner, sibling, parent, child
Popping, cracking or clicking of the joints is not usually a cause for concern, provided that it does not occur all the time and it is not accompanied by symptoms like pain and swelling. However, it still maybe a sign of a problem that is not as yet clearly apparent. In these instances, clicking of a joint may be an early ,, Read More ... ...
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Between 400,000 and 3.1 million adults have Sjögrens syndrome. This condition can affect people of any age, but symptoms usually appear between the ages of 45 and 55. It affects 10 times as many women as men. About half of patients also have rheumatoid arthritis or other connective tissue diseases, such as lupus.. In the early 1900s, Swedish physician Henrik Sjögren (SHOW-gren) first described a group of women whose chronic arthritis was accompanied by dry eyes and dry mouth. Today, rheumatologists know more about the syndrome that is named for Sjögren and-most significantly for patients-can offer advice about how to live with it.. ...
We are committed to a mission of providing the highest quality care for patients with arthritis and autoimmune diseases and mentoring and training medical students, residents, fellows, and young faculty. Our research mission is to better understand arthritis, autoimmune, and other connective tissue diseases in order to improve diagnosis and therapies, with the ultimate goal of finding a cure or preventing these disorders. Faculty members are involved in both clinical and laboratory research. Our research programs are centered in the clinical areas noted above and include the disciplines of clinical epidemiology, health services, and laboratory research. Our research includes collaborative efforts with other programs in the School of Medicine and the Graduate School of Public Health ...
Lupus or SLE (formerly called LED) is a so-called autoimmune connective tissue disease. That means that the bodys own immune system by mistake is attacking connective tissue throughout the body. Read about symptoms, treatment and complications
General rheumatology, metabolic bone disease, osteoporosis, chronic arthritis, rheumatoid arthritis, psoriasis arthritis, ankylosing spondylitis, chronic pain, autoimmune connective tissue disease, systemic lupus erythematosus - SLE, Sjogrens syndrome ...
Systemic sclerosis is an autoimmune connective tissue disease in which T cells play a prominent role. We and others have previously demonstrated a role for T cell-derived IL-13 in mediating the induction of collagen in dermal fibroblasts and that blockade with IL-13 antibodies attenuates this increase. In this study we ... read more want to probe the signalling that underpins IL-13 mediated matrix deposition. Isolated dermal fibroblasts were incubated with recombinant IL-13 and gene expression by qRT-PCR was performed for collagen1A1 and TGF-β1. Small interfering RNA (siRNA) was used to knock down STAT6 and a small molecule inhibitor was also used to block this pathway. MiR-135b was transfected into fibroblasts plus and minus IL-13 to see if this miR plays a role. miR-135b was measured in systemic sclerosis fibroblasts isolated from patients and also in serum. Results showed that IL-13 increased collagen expression and that this is independent from TGF-β1. This is dependent on STAT6 as ...
Interstitial lung diseases (ILD), including those related to connective tissue disease (CTD), and idiopathic pulmonary fibrosis (IPF) carry high morbidity and mortality. Great efforts are under way to develop and investigate meaningful treatments in the context of clinical trials. However, efforts have been challenged by a lack of validated outcome measures and by inconsistent use of measures in clinical trials. Lack of consensus has fragmented effective use of strategies in CTD-ILD and IPF, with a history of resultant difficulties in obtaining agency approval of treatment interventions. Until recently, the patient perspective to determine domains and outcome measures in CTD-ILD and IPF had never been applied. Efforts described here demonstrate unequivocally the value and influence of patient involvement on core set development. Regarding CTD-ILD, this is the first OMERACT working group to directly address a manifestation/comorbidity of a rheumatic disease (ILD) as well as a disease not ...
I live my life with Scleroderma/Systemisk sklerose, which is a very rare autoimmune connective tissue disease. Currently, there is no cure for Scleroderma. Love interior, gardening and cooking. Proud mother of 2 grown children,and lucky grandma to 4 grandchildren. Thanks for stopping by today. Welcome back soon! ...
By: Chris Gellert, PT, MMusc & Sportsphysio, MPT, CSCS, AMS. The shoulder is one of the most vulnerable joints in the body due to its vast range of motion and complexity. It is a complex ball and socket joint, uniquely comprised of various connective tissue, supporting structures, including muscles. It is an important joint because functionally, it is involved in most daily and sport activities, such as reaching, lifting, carrying and throwing a ball. Knowledge of the biomechanics of the shoulder can help you with training and aiding in rehabilitation of the shoulder and related injuries.. The shoulder complex involves coordinated movements between the humerus bone and the scapula. The scapula, clavicle, and humerus serve as attachments for most of the muscles in the shoulder. The shoulder is comprised of four primary joints:. ...
By: Chris Gellert, PT, MMusc & Sportsphysio, MPT, CSCS, AMS. The shoulder is one of the most vulnerable joints in the body due to its vast range of motion and complexity. It is a complex ball and socket joint, uniquely comprised of various connective tissue, supporting structures, including muscles. It is an important joint because functionally, it is involved in most daily and sport activities, such as reaching, lifting, carrying and throwing a ball. Knowledge of the biomechanics of the shoulder can help you with training and aiding in rehabilitation of the shoulder and related injuries.. The shoulder complex involves coordinated movements between the humerus bone and the scapula. The scapula, clavicle, and humerus serve as attachments for most of the muscles in the shoulder. The shoulder is comprised of four primary joints:. ...
Scleroderma is an autoimmune connective tissue disorder that causes excess collagen to form. People with scleroderma may develop thickened hard skin anywhere on their body. The skin appears .... ...
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This is a new section which is currently under construction and will possibly take some time to complete. However, please feel free to have a mooch-in to check if anything new has been added. Wishing you wellness Carole Sian Scrafton :-) Co-Founder - FibroFlutters
Nakajima M, Mizumoto S, Miyake N, Kogawa R, Iida A, Ito H, Kitoh H, Hirayama A, Mitsubuchi H, Miyazaki O, Kosaki R, Horikawa R, Lai A, Mendoza-Londono R, Dupuis L, Chitayat D, Howard A, Leal GF, Cavalcanti D, Tsurusaki Y, Saitsu H, Watanabe S, Lausch E, Unger S, Bonaf? L, Ohashi H, Superti-Furga A, Matsumoto N, Sugahara K, Nishimura G, Ikegawa S; Mutations in B3GALT6, which encodes a glycosaminoglycan linker region enzyme, cause a spectrum of skeletal and connective tissue disorders. Am J Hum Genet. 2013;92:927-934 ...
Pain is pain and we want to be free from it, no matter the source of it. So often we are quick to treat the pain without taking the time to distinguish the
The mean length of stay for AORC-associated hospitalizations was 5 days, and it did not differ much by sex or age. Compared with all hospitalizations, AORC-associated hospitalizations averaged 1.6 days longer mean length of stay, but was even longer for those aged 18 to 44 years. Among the 10 AORC subgroups, mean length of stay was longer than the AORC average for those with gout, diffuse connective tissue disease, soft tissue disorders, and other specified rheumatic conditions. (Reference Table 4.4 PDF CSV ...
Research Institutions: Sir Mortimer B Davis Jewish General Hospital (Montreal, Canada), University of Utah. Disease: Systemic Sclerosis. Research Description: Systemic Sclerosis (SSc), or scleroderma, is a rare, serious multi-system disorder of connective tissue disease. Patients who suffer from this condition have a thickening and hardening of the skin and connective tissues, and the gastrointestinal tract (GIT) is the most commonly involved internal organ in SSc. Decreased motility of the bowel in SSc leads to small intestinal bacterial overgrowth (SIBO), which contributes to symptoms such as pain, fatigue, depression and malnutrition. Treatment for SIBO consists of antibiotics and drugs to increase GIT motility, yet no standard protocol or studies on how to best use these treatments exists. The research team has developed a detailed treatment protocol for SIBO, which they will test at multiple global clinical locations, including sites in the U.S. and Canada. The protocol also includes ...
For the past year or 2, I have been searching for ways to become all natural and organic with the products I use. There are soooo many different blogs, books, etc., that I dont even know what to look for anymore. Im 39. I grew up in a home where my father was a smoker and also….a crop duster. Hed come home from work, thinking nothing of it, play with us before hed get cleaned up. I have a brother and 2 sisters. My brother, 1 of my sisters and myself all worked for my dad at one time or another. I cant BEGIN to list all the health problems my dad and I have. In a quick nutshell about me, Ive had pneumonia 23 times since 2005. Interstitial Lung Disease. I also have an Undifferintiated Connective Tissue disease. No cures for either, and I will be on powerful medications the rest of my life. My brother has lots of joint pain and has had several lipomas removed. My sister started having thyroid problems her senior year in HS and had 1/2 of it removed at that time. She is now 34 and has had ...
Objective. To evaluate plasma markers of endothelial cell activity in patients with pulmonary arterial hypertension (PAH) induced by connective tissue diseases (CTD) before and after 3-month administration of bosentan.. Methods. We quantified E, L and P-selectin (sE-S, sL-S, sP-S), thrombomodulin (TM), monocyte-chemotactic protein 1 (MCP-1), human soluble CD40 ligand (sCD40L), and nitric oxide (NO) in 18 patients and 18 controls. We evaluated right ventricular systolic pressure (RVSP) and the 6-minute walk test (6-MWT).. Results. All plasma markers but sL-S and TM at Time 0 were significantly higher in patients compared with controls. After 3 months of therapy, decreased levels were noted in NO (Time 0 24.05 ± 6.01 mmol/l, Time 1 13.92 ± 3.40 mmol/l; p , 0.001) and sCD40L (Time 0 1685.33 ± 866 pg/ml, Time 1 1055.11 ± 630.6 pg/ml; p = 0.017). In contrast, sP-S was significantly increased (Time 0 88.36 ± 47.76 ng/ml, Time 1 147.21 ± 94.43 ng/ml; p = 0.021). All patients remained stable in ...
As noted in this review, PH may be idiopathic or have disease associations (connective tissue diseases, congenital heart diseases, portal hypertension, HIV infection, drugs) and be associated with pulmonary diseases including COPD, although it is sometimes unclear in the latter case whether it is due to hemodynamic effects of the lung disease itself or overlap with another disorder of the pulmonary vasculature. ...
AESKULISA® Rheumatology Test Kits Connective tissue diseases are systemic autoimmune diseases including SLE, scleroderma, polymyositis/dermatomyo...
A drug approved to treat certain types of cancer has shown promising results in the treatment of patients with scleroderma, according to results from an open-label Phase II trial. While the drugs efficacy must be demonstrated in a Phase III trial, the gold standard for testing a drug, researchers are optimistic that Gleevec could potentially be a weapon against the chronic connective tissue disease for which a treatment has remained elusive.
The news I got is not pretty or happy or pleasant, not by any stretch of the imagination. The hypermobility, there is no treatment or cure other than palliative care, meaning that my excruciating, unmitigated pain will continue without cease or relief, most likely for the rest of my life. Not only that, but it comes with joint slippage and dislocations. Definitely debilitating. Then you have the connective tissue disease and the arthritis, both of which include pain of their own but can be treated. However, there is a distinct possibility of degeneration in time, especially with the arthritis, which is debilitating as well even if the pain is alleviated. It would be nice to have some of the pain taken care of and taken away, even if not all can be. All that, on top of the Hashimotos and Addisons that must be closely managed if Im to live normally or stay alive at all, the food allergies and IBS that can make my life a living hell in the blink of an eye and last for weeks at a time, depression ...
I also made a drawing of our bedroom and how we would change it to accommodate a much wanted addition to our family. I know that first we have to get my health under control before we start trying to get pregnant. We also have to get our finances under control. After that...who knows. I hope to be a Mommy in the next couple of years. I dont know what Id do otherwise. I will talk to Dr. W., the geneticist who specializes in Connective Tissue Diseases, in St. Louis about having children. My rescheduled (yes, again) appointment is in March. Ive had quite a few EDSers tell me that their geneticist told them not to have children, but I think that those are mostly people with vascular type. A few who told me that had a bad case of classical type. I have hypermobility type and do not expect my diagnosis to be changed when I see the geneticist. I have quite a few friends who have H-EDS or C-EDS (and even some with V-EDS) who have had children and are just fine ...
NYHA) Functional Class III symptoms and etiologies of idiopathic or heritable PAH (56%) or PAH associated with connective tissue diseases (33%). The effects diminish over the minimum recommended dosing interval of 4 hours; treatment timing can be adjusted for planned activities.. While there are long-term data on use of treprostinil by other routes of administration, nearly all controlled clinical experience with inhaled treprostinil has been on a background of bosentan (an endothelin receptor antagonist) or sildenafil (a phosphodiesterase type 5 inhibitor). The controlled clinical experience was limited to 12 weeks in duration.. The efficacy of Tyvaso has not been established in patients with significant underlying lung disease (such as asthma or chronic obstructive pulmonary disease). Patients with acute pulmonary infections should be carefully monitored to detect any worsening of lung disease and loss of drug effect.. Tyvaso is a pulmonary and systemic vasodilator. In patients with low ...
RA usually takes time to diagnose. In the early stages, the symptoms can look like symptoms of other conditions like lupus or connective tissue disease. RA symptoms also come and go, so you may feel better before a flare-up happens again. Your doctor may prescribe medication based on your history and the initial physical findings. But its important for you to keep regular follow-up visits. Your doctor will ask about your symptoms, medical history, and risk factors. For testing, your doctor will order blood samples and perform a physical exam. A physical exam involves checking your joints for swelling, tenderness, and range of motion.. If you or your doctor thinks you might have RA, you will want to see a rheumatologist. A rheumatologist specializes in diagnosing and managing RA, and finding a treatment plan to address your needs.. ...
Our clinical team plays an important preventative role by identifying those who might be at risk for osteoporosis as well as by building greater awareness of the need for early diagnosis and treatment. An important procedure for identifying those at risk for osteoporosis, or those who already have the disease, is through bone density testing. We do read these test in our clinic and then give our recommendation in terms of treatment. Consultation and treatment of chronic pain conditions (back/neck, hand/foot pain and other joint pain) is part of our routine work in this clinic.. Joint Aspirations and joint injections (for shoulders, elbows, wrists, hands, knees, ankles, and feet are performed in this clinic.. Specialist diagnostic and treatment services for patients with all forms of rheumatic complaints including connective tissue diseases, inflammatory arthritis, osteoarthritis, and orthopedic medical conditions.. ...
The vision of The Lupus Association of NSW is to work towards a world without lupus and associated connective tissue diseases through support, education, awareness and research into a cure.. ...
Doctor Wemple is a Seattle Magazine top doctor specializing in rheumatology, including rheumatoid arthritis, connective tissue disease, osteoporosis, and more.
Background/Purpose The 14-3-3η protein has been described as a mechanistic marker that is detectable in serum during the very early stages of RA development. A specific anti-14-3-3η autoantibody response is present in RA serum and is postulated to be protective when it effectively clears systemic 14-3-3η. This study examined the baseline expression of 14-3-3η markers (protein and pan-autoantibodies) in a recent onset polyarthritis cohort and their association with the progression of joint damage. Methods 335 subjects were evaluated; 40 DMARD-naïve patients from the Sherbrooke EUPA cohort and 295 controls. Median age was 50 yrs, 2 months median disease duration, 75% were female and 60% were positive for RF and 55% for ACPA. Controls included 106 healthy and 189 disease controls consisting of connective tissue disease, OA, AS or autoimmune disorders. 14-3-3η protein levels were previously tested in this cohort using the Augurex 14-3-3η ELISA (cut-off ≥0.19 ng/ml) and 50% of the recent ...
Our other regular columns have great information as well. "Ask the Experts" answers a few questions, including one about connective tissue disease. "Teen Talk" offers advice on how to make up missed classes, communicate with your teachers, and get the support you need. And "Ask Dr. Paul" gives some suggestions on how to talk with a spouse who always thinks they know whats best for you ...
Design: Randomized placebo-controlled trial. Allocation: {Concealed}†.* Blinding: Blinded (patients, outcome assessors, monitoring committee, {data collectors, and data analysts}†).* Follow-up period: Mean 3.4 years. Setting: A hospital in Guangzhou, China. Patients: 224 patients 18 to 70 years of age (mean age 45 y, 50% men) who had a serum creatinine level 3.1 to 5.0 mg/dL (274 to 442 µmol/L) with , 30% change in the previous 3 months, nondiabetic renal disease, and persistent proteinuria and had not received angiotensin-converting enzyme (ACE) inhibitors in the past 6 weeks. Exclusion criteria included immediate need for dialysis; current treatment with corticosteroids, nonsteroidal antiinflammatory drugs, or immunosuppressive drugs; renovascular disease; myocardial infarction or cerebrovascular events within the previous year; connective tissue disease; and obstructive uropathy. Intervention: Benazepril, 10 mg twice daily (n = 112), or placebo (n = 112). All patients had an 8-week ...
Inflammation normally presents a rapid loss of vision. Colour vision is frequently affected. Occasionally inflammation of the optic nerve may cause pain behind the eyes, especially during eye movements. A diagnosis can usually be made on clinical grounds alone. However, because inflammation is often related to diseases that can affect other parts of the body, such as connective tissue disease and multiple sclerosis, some blood investigations and an MRI may be necessary. Treatment with steroids may be required ...
23 - 25 May 2013, Naantali Spa, Finland. This series of symposia focuses on a single topic of interest, the theme is "Inflammatory reaction in brain disorders". Different aspects of inflammation in the CNS will be covered, eg in neurodegenerative diseases, demyelinating disorders and connective tissue disease. There will also be lectures on general brain immunology. A joint meeting with BrainNet Europe on "Mystery cases" concludes the Symposium.. Link - http://congress.utu.fi/nlns2013. ...
Starting steroids was sort of a miracle, except the part where I will now spend the rest of my life explaining why I am on steroids. I take a physiologic dose of a stigmatized class of medications. It is exactly the same amount a person of my size and activity level would release. And yet I constantly have to explain that. Since I switched from prednisone to hydrocortisone, I am no longer immunosuppressed--my pred dose was just high enough to dampen things a bit. I am not on anywhere near enough for any of the rage or depression or other side effects like that, because I am on the same amount most people just produce on their own. No, I do not want to stop taking it, I like being able to live my life. The bruising is not because of steroid toxicity, it is because I am an extremely active person with a connective tissue disease. Yes, I have put on a buttload of weight since starting the steroids. Because I was substantially underweight and run mesomorphic. Its a good thing, really it is ...
Spleen, (pancreas), meteorism, vein marks on skin, connective tissue diseases, cell respiration, fermentation, enzymatics, liver-stomach-pancreas, dyspepsia & dysbiosis, mammary glands.. All 4ths have a key position similar to the 8th, communication.. [toothbooks]. ...
Spleen, (pancreas), meteorism, vein marks on skin, connective tissue diseases, cell respiration, fermentation, enzymatics, liver-stomach-pancreas, dyspepsia & dysbiosis, mammary glands.. All 4ths have a key position similar to the 8th.. [toothbooks]. ...
A message board created to discuss and share stories and experiences concerning connective tissue disorders. Join, read and post from this site. ...
Arthritis is inflammation of a joint. There are many types of arthritis, both inflammatory and noninflammatory, that affect joints and other connective tissues in the body. The most common types treated by therapists are rheumatoid arthritis and osteoarthritis. Arthrosis is limitation of a joint without inflammation. Unless the cause of the joint problems is known, such as recent trauma or immobility, medical intervention is necessary to diagnose and medically manage the pathology. Traumatic arthritis may require aspiration if there is bloody effusion. The therapist manages the impairments, activity limitations, and participation restrictions that result from the underlying pathology. ...
Thank goodness you show no signs of syndrome, I wouldnt wish connective tissue disorder on anyone!!This may sound strange but you can still do a work out with your lung as it is. At home with free weights, very light free weights. Nothing that makes you hold your breath and place pressure on your lungs, weights just to keep you supple and keep most of the muscle you have while you rest. Stuffing yourself while recovering will only have you gain fat, not much else.You need to look into the pyramid method of weight lifting. Arnold used this method if I remember correctly (unfortunately he was stupid and also used steroids and paid the price later in his life); you will gain far more mass and a lot quicker. But firstly start with a cardiac work out which will help your lungs and heart. Breathe in and out through your nose only and at a steady natural pace (you dont want to hyperventerlate :-) ); this will give you correct balance of oxygen in your blood system which is perfect for you to start ...
Definition of mixed connective tissue diseases in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is mixed connective tissue diseases? Meaning of mixed connective tissue diseases as a legal term. What does mixed connective tissue diseases mean in law?
Connective tissue diseases include Sjogrens syndrome, rheumatoid arthritis, systemic lupus erythematosus, relapsing polychondritis, progressive systemic sclerosis, dermatomyositis and polymyositis, antiphospholipid syndrome, adult-onset Stills disease and mixed connective tissue disorders. These diseases are acquired immunologically, and are mediated inflammatory disorders characterized by abnormal function or structure of one or more of the elements of the connective tissue, namely collagen, elastin or the mucopolysaccharides. It is characterized by production of autoantibody and other immune-mediated dysfunction [3].. Mixed connective tissue disease (MCTD) is an autoimmune condition that affects almost all major organs in the body, most commonly affecting females (80%) between ages of 4-80 years old [4]. There are four sets of criterias used in defining MCTD, namely the Sharp, Alarcon-Segovia, Kakusawa, and Kahn criteria. Upon reevaluation of these criteria by Amigues et al. it is concluded ...
... definition, Heritable Disorders Of Connective Tissue mortality and morbidity, Heritable Disorders Of Connective Tissue treatment, manifestations of the Heritable Disorders Of Connective Tissue, Heritable Disorders Of Connective Tissue race, Heritable Disorders Of Connective Tissue function, Heritable Disorders Of Connective Tissue care, Heritable Disorders Of Connective Tissue frequency, what causes Heritable Disorders Of Connective Tissue, Heritable Disorders Of Connective Tissue prevalence, Heritable Disorders Of Connective Tissue role, Heritable Disorders Of Connective Tissue associated with the deficiency, Heritable Disorders Of Connective Tissue recorded mutations , Heritable Disorders Of Connective Tissue hormonal conditions with the deficiency, Heritable Disorders Of Connective Tissue developmental delays, more serious problems caused by the Heritable Disorders Of Connective Tissue, Heritable Disorders Of Connective Tissue inheritance, Heritable Disorders
TY - JOUR. T1 - Severe rhizomelic chondrodysplasia punctata in a fetus due to maternal mixed connective tissue disorder. AU - Nayak, S. S.. AU - Adiga, P. K.. AU - Rai, L.. AU - Girisha, K. M.. PY - 2012. Y1 - 2012. N2 - Maternal systemic lupus erythematosus and autoimmune diseases have been extremely rarely reported to cause rhizomelic chondrodysplasia punctata. We report on a fetus aborted spontaneously at 21 weeks of gestation due to complications of maternal mixed connective tissue disorder. The fetus had micrognathia, a depressed nasal bridge, flat nose, long philtrum, short columella and rhizomelia. Radiographic study showed stippling of carpal and tarsal bones, short humeri and coronal clefts in the vertebrae. Ossification centers were present at the lower end of the femora and upper end of the tibiae.. AB - Maternal systemic lupus erythematosus and autoimmune diseases have been extremely rarely reported to cause rhizomelic chondrodysplasia punctata. We report on a fetus aborted ...
Silicone gets a bad rap when it comes to breast implants. Years ago when silicone breast implants were first introduced, they were thin shells filled with the silicone gel. Ruptures happened and there were safety concerns related to the implants. Today, after ten years without silicone breast implants, new forms of the gel-filled implants are back, safer and even more realistic than ever.. Silicone Breast Implants Are Safe. Often women dont think silicone breast implants are safe. Theyve heard about problems that women had more than a decade ago and have decided saline was the way to go. The newest forms of silicone gel are considered just as safe as silicone. The lining of the pouches is thicker, more care is used in creating the implants and doctors are inserting the implants in improved methods as well.. Silicone Breast Implants Arent Permanent. When you opt for silicone breast implants youre going to have a natural looking chest and your cleavage and movement will be very natural as ...
Plastic Surgery Portal is the most trusted source for Silicone Breast Implants information in Geneva. Our Illinois plastic and cosmetic surgeons have the answers to your questions about Silicone Breast Implants such as recovery time, cost of surgery, and more. For the top Silicone Breast Implants plastic surgeons in Geneva, were a resource you can depend on.
literature and ongoing studies on breast implants, entitled Safety of Silicone Breast Implants. The report made a clear distinction between local complications and systemic health concerns. It concluded that local complications were "the primary safety issue with silicone breast implants." These local complications, which included rupture, pain, capsular contracture, disfigurement, and serious infection are common for both silicone and saline implants.. Most importantly, the report concluded that there was NO EVIDENCE that silicone breast implants caused systemic health effects such as cancer, autoimmune disease or reproductive problems.. In 2006, the new cohesive gel implants were introduced to the market after thorough FDA investigation and approval.. If you are interested in silcone breast implantation, please call us at the Beverly Hills Plastic Surgery Group for your free consultation at (310) 853-5147.. ...
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Acute transverse myelitis (ATM) is commonly para-infectious. Recurrent ATM occurs in connective tissue diseases (CTD), infective myelitis and idiopathic inflammatory demyelinating disorders (IIDD) including multiple sclerosis (MS) and neuromyelitis optica (NMO). Previous studies might include NMO an

Mixed Connective Tissue DiseaseMixed Connective Tissue Disease

... is a rare autoimmune disorder featuring signs and symptoms of three different disorders: lupus ... Mixed Connective Tissue Disease. What is Mixed Connective Tissue Disease?. Mixed connective tissue disease (MCTD) is a rare ... Mixed Connective Tissue Disease Causes. No one knows exactly what causes the immune system to attack the bodys tissues in ... Mixed Connective Tissue Disease Symptoms. Symptoms of the different diseases that make up MCTD usually dont begin at the same ...
more infohttps://www.arthritis.org/about-arthritis/types/mixed-connective-tissue-disease/

Mixed connective tissue disease - Symptoms and causes - Mayo ClinicMixed connective tissue disease - Symptoms and causes - Mayo Clinic

Mixed connective tissue disease has signs and symptoms of multiple disorders, making it difficult to diagnose. Theres no cure ... The precise cause of mixed connective tissue disease isnt known.. Mixed connective tissue disease is an autoimmune disorder. ... com/professional/musculoskeletal-and-connective-tissue-disorders/autoimmune-rheumatic-disorders/mixed-connective-tissue-disease ... In mixed connective tissue disease, the symptoms of the separate diseases usually dont appear all at once. Instead, they tend ...
more infohttps://www.mayoclinic.org/diseases-conditions/mixed-connective-tissue-disease/symptoms-causes/syc-20375147?METHOD=print

Mixed Connective Tissue Disease - MCTD | ARUPConsultMixed Connective Tissue Disease - MCTD | ARUPConsult

... an autoimmune disease often referred to as overlap syndrome. RNP antibodies found in 95-100% MCTD patients ... Mixed Connective Tissue Disease - MCTD Mixed connective tissue disease (MCTD) is a complex, systemic, autoimmune disease and ... Individuals with mixed connective tissue disease (MCTD) may demonstrate symptoms associated with other connective tissue or ... Connective Tissue Diseases - Systemic Autoimmune Rheumatic Diseases*Antinuclear Antibody Disease Testing Algorithm ...
more infohttps://arupconsult.com/content/mixed-connective-tissue-disease

Mixed Connective Tissue Disease (MCTD) - NORD (National Organization for Rare Disorders)Mixed Connective Tissue Disease (MCTD) - NORD (National Organization for Rare Disorders)

Mixed connective tissue disease. Curr Opin Rheumatol. 2000;12:386-90.. Maddison PJ. Mixed connective tissue disease: overlap ... Individuals with mixed connective tissue disease have symptoms that overlap with those of two or more connective tissue ... Mixed connective tissue disease (MTCD) is an uncommon systemic inflammatory rheumatic disease. MCTD is a specific subset of the ... Greidinger EL, Mixed Connective Tissue Disease, In: Encyclopedia of Medical Immunology: Autoimmune Diseases, MacKay I and Rose ...
more infohttps://rarediseases.org/rare-diseases/mixed-connective-tissue-disease-mctd/

Mixed connective tissue diseases legal definition of mixed connective tissue diseasesMixed connective tissue diseases legal definition of mixed connective tissue diseases

What is mixed connective tissue diseases? Meaning of mixed connective tissue diseases as a legal term. What does mixed ... Definition of mixed connective tissue diseases in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... Mixed connective tissue diseases legal definition of mixed connective tissue diseases https://legal-dictionary. ... disease. (redirected from mixed connective tissue diseases). Also found in: Dictionary, Thesaurus, Medical, Encyclopedia. ...
more infohttps://legal-dictionary.thefreedictionary.com/mixed+connective+tissue+diseases

External links relating to Mixed connective tissue disease - RightDiagnosis.comExternal links relating to Mixed connective tissue disease - RightDiagnosis.com

Overview of Mixed connective tissue disease as a medical condition including introduction, prevalence, prognosis, profile, ... eMedicine - Mixed Connective Tissue Disease : Article by Anna Wozniacka, MD, PhD *eMedicine - Mixed Connective-Tissue Disease ... They list Mixed connective tissue disease as a "rare disease". Source - Orphanet » Next page: Ask Question about Mixed ... Source: Diseases Database. *eMedicine - Mixed Connective Tissue Disease : Article by Marisa S Klein-Gitelman, MD, MPH, MS * ...
more infohttp://www.rightdiagnosis.com/m/mixed_connective_tissue_disease/references.htm

Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review -...Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review -...

... is a major pulmonary manifestation of connective tissue disease (CTD), leading to significant morbidity and mortality. Chest ... lung disease (ILD) is a major pulmonary manifestation of connective tissue disease (CTD), leading to significant morbidity and ... Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a literature review. ... Original Article: Usefulness of lung ultrasound B-lines in connective tissue disease-associated interstitial lung disease: a ...
more infohttps://www.bioportfolio.com/news/article/3324005/Usefulness-of-lung-ultrasound-B-lines-in-connective-tissue-disease-associated-interstitial.html

Is Mixed Connective Tissue Disease A Disability?Is Mixed Connective Tissue Disease A Disability?

Mixed connective tissue disease patients can claim disability benefits as it is considered as a disability. Read on to know ... Is Mixed Connective Tissue Disease A Disability?. Mixed connective tissue disease (MCTD) is an autoimmune disease that shows ... of people with mixed connective tissue disease die from heart disease.. *Kidney Problems. mixed connective tissue disease may ... Causes Of Mixed Connective Tissue Disease. Mixed connective tissue disease is caused by unknown reason. It is an autoimmune ...
more infohttps://www.epainassist.com/personal-injury/disability/is-mixed-connective-tissue-disease-a-disability

Mixed connective tissue disease with no name.... - Pain - Condition | Our HealthMixed connective tissue disease with no name.... - Pain - Condition | Our Health

I have a mixed connective tissue disease that does not currently have a name. I was tested for marfans syndrome and it was ...
more infohttp://www.ourhealth.com/conditions/pain/mixed-connective-tissue-disease-with-no-name

Mixed Connective Tissue Disease - MCTDfoundation.orgMixed Connective Tissue Disease - MCTDfoundation.org

What is Connective Tissue?. Connective tissue is the fibrous tissue that makes up the framework of your body. As the immune ... com/professional/musculoskeletal-and-connective-tissue-disorders/autoimmune-rheumatic-disorders/mixed-connective-tissue-disease ... and-muscle-disorders/autoimmune-disorders-of-connective-tissue/mixed-connective-tissue-disease-mctd ... About Mixed Connective Tissue Disease. MCTD is an autoimmune disease which occurs when a persons immune system decides to ramp ...
more infohttp://mctdfoundation.org

Mixed connective tissue disease and pregnancy - Pregnancy BlogMixed connective tissue disease and pregnancy - Pregnancy Blog

Mixed connective tissue disease and pregnancy. Ovulation mixed connective tissue disease and pregnancy all your symptoms ... paid some attention to me mixed connective tissue disease and pregnancy the others stood mixed connective tissue disease and ... Women who suffer mixed connective tissue disease and pregnancy these problems go to the physicians and spend a lot of money in ... Mixed connective tissue disease and pregnancy the best kind of Seasonal Event is the one that simply adds a large and different ...
more infohttp://gwendolinelamour.com/and-pregnancy/mixed-connective-tissue-disease-and-pregnancy.html

Undifferentiated Connective Tissue Disease Stories - HSS Back in the GameUndifferentiated Connective Tissue Disease Stories - HSS Back in the Game

Undifferentiated Connective Tissue Disease stories from our community of patients. Read how these patients from all walks of ...
more infohttps://backinthegame.hss.edu/conditions-treatments/undifferentiated-connective-tissue-disease/

Rheumatoid Arthritis, Mixed Connective Tissue Disease and good advice - Arthritic ChickRheumatoid Arthritis, Mixed Connective Tissue Disease and good advice - Arthritic Chick

Certainly not Mixed Connective Tissue Disease, which is so diverse that telling someone you have Mixed Connective Tissue ... Next articleMicrovascular Coronary Disease and Rheumatoid Arthritis and Mixed Connective Tissue Disease ... mixed connective tissue disease, lupus, spondylitis…how will they ever know what these diseases really are and how they affect ... Home My story Rheumatoid Arthritis, Mixed Connective Tissue Disease and good advice ...
more infohttps://www.arthriticchick.com/my-story/rheumatoid-arthritis-mixed-connective-tissue-disease-and-good-advice

Evaluation and Management of Connective Tissue Disease-Associated Interstitial Lung Disease
 | Courses | PHAEvaluation and Management of Connective Tissue Disease-Associated Interstitial Lung Disease | Courses | PHA

... and interstitial lung disease (ILD), particularly in the PH patient. Clinicians that care for these patients will benefit from ... a deeper understanding of CTD and the ILD aspects of this diverse spectrum of disease. There are many clinical dilemmas to ... There are complex interactions between connective tissue disease (CTD) ... Evaluation and Management of Connective Tissue Disease-Associated Interstitial Lung Disease. Aryeh Fischer. Reviews. Sign in to ...
more infohttp://www.phaonlineuniv.org/Courses/Course.cfm?ItemNumber=6026

Altheas Fight Like a Girl Story (Mixed Connective Tissue Disease) | Fight Like a GirlAlthea's Fight Like a Girl Story (Mixed Connective Tissue Disease) | Fight Like a Girl

Altheas Fight Like a Girl Story (Mixed Connective Tissue Disease). admin3 June 21, 2013 Mixed Connective Tissue Disease ... Mixed Connective Tissue Disease Stories / Altheas Fight Like a Girl Story (Mixed Connective Tissue Disease) ... Tags MCTD Mixed Connective Tissue Disease power stories. Previous Yvonnes Fight Like A Girl Story (Mixed Connective Tissue ... Next Juakinas Fight Like a Girl Story (MCTD aka Mixed Connective Tissue Disease, Lupus) ...
more infohttps://www.fightlikeagirlclub.com/altheas-fight-like-a-girl-story-mixed-connective-tissue-disease/

A Rare Occurrence of Focal Atrial Tachycardia in a Patient with Mixed Connective Tissue Disease and Chronic Rheumatic Heart...A Rare Occurrence of Focal Atrial Tachycardia in a Patient with Mixed Connective Tissue Disease and Chronic Rheumatic Heart...

Mixed connective tissue disease Scleroderma Systemic sclerosis Systemic lupus erythematosus Arrhythmia Polymyositis ... adult-onset Stills disease and mixed connective tissue disorders. These diseases are acquired immunologically, and are ... and for it to occur in a patient with underlying mixed connective tissue disease and chronic rheumatic heart disease, who is ... Myocarditis in mixed connective tissue disease: A case report. J Clin Case Rep 6: 1-679.. Razek AA (2016) Imaging of connective ...
more infohttps://www.credoweb.ro/publication/440/a-rare-occurrence-of-focal-atrial-tachycardia-in-a-patient-with-mixed-connective-tissue-disease-and-chronic-rheumatic-heart-disease-a-possible-linkage

204-20-9 87204-20-9 87

31 Shenne E. Gabriel et al., Risk of Connective-Tissue Diseases and Other Disorders After Breast Implantation, 330 N. ENG. J. ... and a variety of connective-tissue, autoimmune diseases such as scleroderma, rheumatoid arthritis, human adjuvant disease, and ... relationship between silicone breast implants and an increased risk of connective tissue and other forms of auto-immune disease ... or prevention of disease, in man or other animals, or (3) intended to affect the structure or any function of the body of man ...
more infohttps://dash.harvard.edu/bitstream/handle/1/8965595/sgranoff.html?sequence=2

Jury Still Out on Silicone Breast Implant Safety - MedBroadcast.comJury Still Out on Silicone Breast Implant Safety - MedBroadcast.com

... connective tissue diseases, multiple sclerosis or other health conditions.. A few studies did find an association between the ... reproductive problems or connective tissue diseases, like rheumatoid arthritis and fibromyalgia.. Studies in the years since ... "At this point, weve had study after study suggesting that implants are not associated with any disease risk, at least in the ... According to the FDA, they include breast pain, capsular contracture -- a hardening of the breast tissue around the implant -- ...
more infohttp://www.medbroadcast.com/news/2039/37179?newssource=1

Breast implants - Part 2Breast implants - Part 2

It is also not proven that implants will cause a connective tissue disease as once thought. ... but the breast tissue may sag. If the implants are over the muscle, the weight of the breast tissue might affect the shape of ... Additionally, there is less rippling for women who do not have much breast tissue. However, Dr. Delgado will want to discuss ... How much skin and soft tissue is available to cover the implants. • Distance between the nipples. • The location of the nipples ...
more infohttp://breastrevisionsanfrancisco.com/category/breast-implants/page/2/

Connective tissue diseases | Open LibraryConnective tissue diseases | Open Library

Collagen diseases, Connective Tissue Diseases, Connective Tissue, Diseases, Connective tissues, Internet Archive Wishlist ... Connective tissue diseases by Graham R. V. Hughes; 4 editions; First published in 1977; Subjects: ... Collagen diseases, Connective Tissue Diseases, Connective Tissue, Diseases, Connective tissues, Internet Archive Wishlist ... You could add Connective tissue diseases to a list if you log in. ... Are you sure you want to remove Connective tissue diseases from ...
more infohttps://openlibrary.org/works/OL3949016W/Connective_tissue_diseases

ICD-11 - Mortality and Morbidity StatisticsICD-11 - Mortality and Morbidity Statistics

ICD maintenance process allows the continuous adaptation of the ICD following the evolution in the understanding of diseases, ...
more infohttps://icd.who.int/browse11/l-m/en

Connective tissue disease | The BMJConnective tissue disease | The BMJ

This site uses cookies. More info Close By continuing to browse the site you are agreeing to our use of cookies. Find out more here Close ...
more infohttp://www.bmj.com/specialties/connective-tissue-disease?page=6

Mixed Connective Tissue Disease | SpringerLinkMixed Connective Tissue Disease | SpringerLink

Pulmonary Hypertension Connective Tissue Disease Mixed Connective Tissue Disease Undifferentiated Connective Tissue Disease ... Kasukawa R. (2005) Mixed Connective Tissue Disease. In: Hertl M. (eds) Autoimmune Diseases of the Skin. Springer, Vienna. * DOI ... Mixed connective tissue disease: an apparently distinct rheumatic disease syndrome associated with a specific antibody to an ... Classification and diagnostic criteria for mixed connective tissue disease. In: Kasukawa R, Sharp GC (eds) Mixed Connective ...
more infohttps://link.springer.com/chapter/10.1007/3-211-27377-8_12

Mixed Connective-Tissue Disease Differential DiagnosesMixed Connective-Tissue Disease Differential Diagnoses

Mixed connective-tissue disease (MCTD) was first recognized by Sharp and colleagues (1972) in a group of patients with ... of mixed connective tissue disease differ distinctly from the profiles of clinically related connective tissue diseases. ... Classification and diagnostic criteria for mixed connective tissue disease. Kasukawa R, Sharp GC, eds. Mixed Connective Tissue ... encoded search term (Mixed%20Connective-Tissue%20Disease) and Mixed Connective-Tissue Disease What to Read Next on Medscape. ...
more infohttps://emedicine.medscape.com/article/335815-differential

Connective tissue disease | BMJ OpenConnective tissue disease | BMJ Open

BMJ Open Jan 2011, 1 (1) e000070; DOI: 10.1136/bmjopen-2011-000070 ...
more infohttps://bmjopen.bmj.com/collection/connective-tissue-disease
  • Other medications may be prescribed to treat or reduce the risk of certain complications of the disease. (arthritis.org)
  • Disease of the lymph nodes (lymphadenopathy), enlargement of the spleen (splenomegaly), enlargement of the liver (hepatomegaly), and intestinal involvement may also occur in some cases. (rarediseases.org)
  • Mixed connective tissue disease causes so much deformity in the affected joints or organs that it becomes very hard for the patient to perform normal activities like lifting arms, climbing stairs, getting out of chair etc. (epainassist.com)
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