A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.
Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.
Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
A collective term for diseases of the skin and its appendages and of connective tissue.
Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
The protein components that constitute the common core of small nuclear ribonucleoprotein particles. These proteins are commonly referred as Sm nuclear antigens due to their antigenic nature.
A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.
A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.
Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.
Implants used to reconstruct and/or cosmetically enhance the female breast. They have an outer shell or envelope of silicone elastomer and are filled with either saline or silicone gel. The outer shell may be either smooth or textured.
Inflammation of a muscle or muscle tissue.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U1 snRNP along with other small nuclear ribonucleoproteins (U2, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction.
Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.
Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)
A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.
A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
Mucoid states characterized by the elevated deposition and accumulation of mucin (mucopolysaccharides) in dermal tissue. The fibroblasts are responsible for the production of acid mucopolysaccharides (GLYCOSAMINOGLYCANS) in the ground substance of the connective tissue system. When fibroblasts produce abnormally large quantities of mucopolysaccharides as hyaluronic acid, chondroitin sulfate, or heparin, they accumulate in large amounts in the dermis.
Highly conserved nuclear RNA-protein complexes that function in RNA processing in the nucleus, including pre-mRNA splicing and pre-mRNA 3'-end processing in the nucleoplasm, and pre-rRNA processing in the nucleolus (see RIBONUCLEOPROTEINS, SMALL NUCLEOLAR).
Complexes of RNA-binding proteins with ribonucleic acids (RNA).
Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.
The thin, horny plates that cover the dorsal surfaces of the distal phalanges of the fingers and toes of primates.
A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)
A group of interstitial lung diseases with no known etiology. There are several entities with varying patterns of inflammation and fibrosis. They are classified by their distinct clinical-radiological-pathological features and prognosis. They include IDIOPATHIC PULMONARY FIBROSIS; CRYPTOGENIC ORGANIZING PNEUMONIA; and others.
An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
The noninvasive microscopic examination of the microcirculation, commonly done in the nailbed or conjunctiva. In addition to the capillaries themselves, observations can be made of passing blood cells or intravenously injected substances. This is not the same as endoscopic examination of blood vessels (ANGIOSCOPY).
Any one of five terminal digits of the vertebrate FOOT.
The branch of surgery concerned with restoration, reconstruction, or improvement of defective, damaged, or missing structures.
A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and kidneys. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against neutrophil proteinase-3 (WEGENER AUTOANTIGEN).
Small RNAs found in the cytoplasm usually complexed with proteins in scRNPs (RIBONUCLEOPROTEINS, SMALL CYTOPLASMIC).
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.
Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.
Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disorders of the brain stem nuclei from which the cranial nerves originate or terminate.
Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.
Immunoelectrophoresis in which immunoprecipitation occurs when antigen at the cathode is caused to migrate in an electric field through a suitable medium of diffusion against a stream of antibody migrating from the anode as a result of endosmotic flow.
A primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.
Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).
Four or five slender jointed digits in humans and primates, attached to each HAND.
Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.
Proteins conjugated with nucleic acids.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Immunologically detectable substances found in the CELL NUCLEUS.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.
Compression of the heart by accumulated fluid (PERICARDIAL EFFUSION) or blood (HEMOPERICARDIUM) in the PERICARDIUM surrounding the heart. The affected cardiac functions and CARDIAC OUTPUT can range from minimal to total hemodynamic collapse.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
A PREDNISOLONE derivative with similar anti-inflammatory action.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Silicone breast implants: epidemiological evidence of sequelae. (1/463)

Skeptics may certainly find fault with the third study (the only one to report a significant finding) or with all or any of the statistics described. But few could argue, after examining these studies, that the relative risk for a known and well-defined connective tissue disease is likely greater than 2. Another possibility has been raised, one that calls to mind other difficult-to-study syndromes linked to exposures. In a study addressing Gulf War syndrome, signs and symptoms were often mentioned that proved difficult to describe systematically and therefore difficult to study. What if a suspected silicone exposure syndrome were so mild and transient that it did not warrant a physician visit (as in the Mayo Clinic study). receive a diagnosis (as in the Nurses' Health Study), or require admission to a hospital (as in the Danish and Swedish studies)? And if such a disorder were, in fact, mild and transient, should it merit the concern that has been shown and the compensation that has been awarded in the silicone implant litigation cases to date? We suggest that neither a well-described disorder with a relative risk of less than 2 nor a transient and mild disorder seems compatible with the number of litigants over silicone implants and the apparent seriousness of their complaints. Some 400,000 women joined in one class action suit for damages, and 170,000 joined in another. Even if there had been 2 million implants undertaken in the United States over the 3 decades in which implant surgery has been practiced (and some estimates put the number closer to 1 million), there is no conceivable way in which a relative risk of 2 or 3 (or even 4) for each of the rare syndromes reported could explain so many exposed women being affected. At most, 2200 out of 2 million unexposed women would be expected to have had any one of the listed forms of connective tissue disorders, most of which are very rare. Doubling the risk among the exposed population yields 4400, and increasing the risk 20-fold produces 44,000. At this rate, there is no way in which 400,000 litigants could all be affected. Extensions of the already-completed studies are ongoing, at least 1 of which is government funded; apparently it is thought in the United States (though not in the United Kingdom or elsewhere) that there is still room for reasonable doubt as to the supposed causal relationships. But if epidemiology is invoked in the interest of public health to prevent the many uses of silicone, the weight of the evidence abstracted here supports the inference that silicone breast implants have not been proved guilty of causing connective tissue disorders.  (+info)

Pulmonary artery pressure variation in patients with connective tissue disease: 24 hour ambulatory pulmonary artery pressure monitoring. (2/463)

BACKGROUND: The specific contribution of secondary pulmonary hypertension to the morbidity and mortality of patients with underlying lung disease can be difficult to assess from single measurements of pulmonary artery pressure. We have studied patients with secondary pulmonary hypertension using an ambulatory system for measuring continuous pulmonary artery pressure (PAP). We chose to study patients with connective tissue disease because they represent a group at high risk of pulmonary vascular disease, but with little disturbance of lung function. METHODS: Six patients (five with progressive systemic sclerosis and one with systemic lupus erythematosis) were studied. They underwent preliminary cardiopulmonary investigations followed by Doppler echocardiography, right heart catheterisation, and ambulatory pulmonary artery pressure monitoring to measure changes in pressure over a 24 hour period including during a formal exercise test. RESULTS: All patients had pulmonary hypertension as measured by Doppler echocardiography with estimated pulmonary artery systolic pressures of 40-100 mm Hg. Pulmonary function testing revealed virtually normal spirometric values (mean FEV1 86.9% predicted) but marked reduction in CO gas transfer factor (KCO 57.8% predicted). Exercise responses were impaired with mean VO2max 50.6% predicted. Ambulatory PAP monitoring indicated significant changes in pressures with variation in posture and activity throughout 24 hours. Resting PAP did not predict the change in PAP seen on exercise. CONCLUSION: Conventional methods of assessment of the pulmonary circulation based on single measurements in the supine position may underestimate the stresses faced by the right side of the circulation. This ambulatory system allows monitoring of pulmonary haemodynamics continuously over 24 hours during normal activities of daily living. These measurements may increase our understanding of the contribution made by secondary pulmonary hypertension to the morbidity and mortality of the underlying lung disease.  (+info)

Petroleum distillate solvents as risk factors for undifferentiated connective tissue disease (UCTD). (3/463)

Occupational solvent exposure may increase the risk of connective tissue disease (CTD). The objective of this case-control study was to investigate the relation between undifferentiated connective tissue disease (UCTD) and solvent exposure in Michigan and Ohio. Women were considered to have UCTD if they did not meet the American College of Rheumatology classification criteria for any CTD but had at least two documented signs, symptoms, or laboratory abnormalities suggestive of a CTD. Detailed information on solvent exposure was ascertained from 205 cases, diagnosed between 1980 and 1992, and 2,095 population-based controls. Age-adjusted odds ratios (OR) and 95 percent confidence intervals (CI) were calculated for all exposures. Among 16 self-reported occupational activities with potential solvent exposure, furniture refinishing (OR = 9.73, 95 percent CI 1.48-63.90), perfume, cosmetic, or drug manufacturing (OR = 7.71, 95 percent CI 2.24-26.56), rubber product manufacturing (OR = 4.70, 95 percent CI 1.75-12.61), work in a medical diagnostic or pathology laboratory (OR = 4.52, 95 percent CI 2.27-8.97), and painting or paint manufacturing (OR = 2.87, 95 percent CI 1.06-7.76) were significantly associated with UCTD. After expert review of self-reported exposure to ten specific solvents, paint thinners or removers (OR = 2.73, 95 percent CI 1.80-4.16) and mineral spirits (OR = 1.81, 95 percent CI 1.09-3.02) were associated with UCTD. These results suggest that exposure to petroleum distillates increases the risk of developing UCTD.  (+info)

Up-regulation of intercellular adhesion molecule-1 (ICAM-1), endothelial leucocyte adhesion molecule-1 (ELAM-1) and class II MHC molecules on pulmonary artery endothelial cells by antibodies against U1-ribonucleoprotein. (4/463)

In order to elucidate the pathogenic role(s) of autoantibodies in connective tissue disease (CTD), we examined whether autoantibodies against U1-ribonucleoprotein (RNP) and double-stranded (ds) DNA can up-regulate ICAM-1, ELAM-1 and class I and II MHC molecule expression on pulmonary artery endothelial cells (HPAEC). ICAM-1, ELAM-1 and class II MHC molecule expression on HPAEC cultured in the presence of anti-U1-RNP-containing and anti-dsDNA-containing IgG from CTD patients was up-regulated significantly in comparison with that on HPAEC cultured with IgG from normal healthy volunteers. Affinity chromatographic enrichment and depletion of the anti-U1-RNP antibody content of anti-U1-RNP-containing IgG confirmed that the anti-U1-RNP antibody did up-regulate ICAM-1, ELAM-1 and class II MHC molecule expression. The finding that an IgG F(ab')2-purified anti-U1-RNP antibody also up-regulated expression of these molecules may indicate that mechanisms other than Fc receptor-mediated stimulation are involved. These in vitro findings suggest that autoantibodies against U1-RNP and dsDNA play important roles in the immunopathological processes leading to the proliferative pulmonary arterial vasculopathy observed in CTD patients with pulmonary hypertension by up-regulating adhesion and class II MHC molecule expression on endothelial cells.  (+info)

T cell receptor beta-chain third complementarity-determining region gene usage is highly restricted among Sm-B autoantigen-specific human T cell clones derived from patients with connective tissue disease. (5/463)

OBJECTIVE: To determine the structure of T cell receptors (TCR) used by Sm-B-reactive human T cell clones, to map T cell epitopes on the Sm-B autoantigen, and to determine the HLA restriction element used in the recognition of Sm-B by T cells. METHODS: Sm-B-reactive T cell clones were generated from patients with connective tissue disease by using either a recombinant fusion protein or synthetic peptides. The TCR structure was defined with the use of polymerase chain reaction and DNA sequencing. Synthetic peptides were used to map T cell epitopes on Sm-B. HLA restriction element usage was defined by using monoclonal antibody blocking. RESULTS: Usage of the TCR third complementarity-determining region (CDR3) was highly restricted among Sm-B autoantigen-specific human T cell clones. Only amino acids 48-96 of the Sm-B2 autoantigen were recognized by T cells, and this occurred in the context of HLA-DR. CONCLUSION: TCR CDR3 gene usage is highly conserved by Sm-B autoantigen-specific T cell clones, and this appears to be related to the recognition of a limited number of T cell epitopes on the Sm-B autoantigen presented in the context of HLA-DR.  (+info)

Pneumocystis carinii pneumonia in patients with connective tissue diseases: the role of hospital experience in diagnosis and mortality. (6/463)

OBJECTIVE: Pneumonia due to Pneumocystis carinii has been increasingly reported in patients with connective tissue diseases, but the frequency of this complication is not known. We sought to determine the frequency of P carinii pneumonia (PCP) in patients with connective tissue diseases, and to determine the role that a hospital's acquired immunodeficiency syndrome (AIDS)-related experience may have in the diagnosis of PCP in these patients. METHODS: We used a state hospitalization registry to identify all patients with PCP and either rheumatoid arthritis, systemic lupus erythematosus, Wegener's granulomatosis, polymyositis, dermatomyositis, polyarteritis nodosa, or scleroderma who had an emergent or urgent hospitalization in California from 1983 to 1994. We compared patient and hospital characteristics between these patients and patients with connective tissue diseases hospitalized with other types of pneumonia. RESULTS: Two hundred twenty-three patients with connective tissue diseases were diagnosed with PCP in the 12-year study period. The frequency of PCP ranged from 89 cases/10,000 hospitalizations/year in patients with Wegener's granulomatosis to 2 cases/10,000 hospitalizations/year in patients with rheumatoid arthritis. Compared with 5,457 patients with connective tissue diseases and pneumonia due to other organisms, patients with PCP were more likely to be younger, to be male, to have private medical insurance, and to have systemic lupus erythematosus, Wegener's granulomatosis, inflammatory myopathy, or polyarteritis nodosa rather than rheumatoid arthritis, and were less likely to be African American. Hospital size, teaching status, urban/rural location, proportion of admissions due to AIDS or PCP, and proportion of patients with pneumonia undergoing bronchoscopy were each associated with the likelihood of diagnosis of PCP in univariate analyses, but only the number of patients with PCP being treated at a hospital (odds ratio [OR] 1.03 for each additional 10 cases/year, 95% confidence interval [95% CI] 1.01-1.05) was associated with the likelihood of diagnosis of PCP in multivariate analyses. Patients were also somewhat more likely to be diagnosed with PCP if there had previously been a case of PCP in a patient with a connective tissue disease at the same hospital (OR 135, 95% CI 0.98-1.85). In-hospital mortality was 45.7%, and was unrelated to hospital characteristics. CONCLUSION: PCP is an uncommon, but often fatal, occurrence in patients with connective tissue disease. A hospital's prior experience with patients with PCP is associated with the likelihood that this condition is diagnosed in patients with connective tissue diseases who present with pneumonia, suggesting that diagnostic suspicion is an important factor in the correct identification of affected patients.  (+info)

Joint hypermobility and genetic collagen disorders: are they related? (7/463)

The HDCTs constitute a heterogeneous group of rare genetically determined diseases, the best known of which are Ehlers-Danlos and Marfan syndromes and osteogenesis imperfecta. Hypermobility is a feature common to them all, but it is also a feature that is highly prevalent in the population at large. Symptomatic hypermobile subjects (whose symptoms are attributable to their hypermobility) are said to be suffering from the benign joint hypermobility syndrome, which has many features that overlap with the HDCTs. It is not yet known whether there is a variety of hypermobility (symptomatic or otherwise) that is not part of a connective tissue disorder.  (+info)

111Indium antimyosin antibody imaging of primary myocardial involvement in systemic diseases. (8/463)

OBJECTIVE: The diagnosis of primary myocardial involvement in systemic diseases is clinically relevant but difficult in the absence of specific criteria. Whatever the underlying disease, myocytes degeneration is observed during the active phase of myocardial damage. The aim of this study was to assess the diagnostic value of scintigraphic imaging with 111Indium antimyosin antibody (AM), a specific marker of the damaged myocyte, for ongoing myocardial damage related to systemic diseases. METHODS: 40 patients with histologically confirmed systemic diseases were studied. They were classified into two groups according to the presence (group 1, n = 30), or the absence (group 2, n = 10) of clinical, electrocardiographic (ECG) or echocardiographic signs suggestive of myocardial involvement. Planar and tomographic acquisitions were obtained 48 hours after injection of AM (90 MBq). Rest 201thallium (T1) scintigraphy was also performed to assess myocardial perfusion and scarring. Clinical, ECG, and echocardiographic +/- scintigraphic evaluations were repeated during follow up (17 +/- 19 months) in 36 of 40 patients. RESULTS: In group 1, 13 of 30 patients (43%) showed diffuse significant AM uptake throughout the left ventricle (LV), and no or mild T1 abnormality. Two of these were asymptomatic, four had normal ECG, and two had no clinical or echographic LV dysfunction. All patients in group 2 had negative AMA scintigraphy and normal T1 scintigraphy. During follow up of 12 AM positive patients, cardiac status improved after immunosuppressive treatment was intensified in nine cases, worsened in two cases, and remained stable in one. During follow up of 24 AM negative patients, cardiac status remained stable in 23 cases despite treatment not being increased in 20, including two patients with sequellary myocardial involvement. The last patient developed mild LV dysfunction after 36 months. CONCLUSION: AM scintigraphy allows detection of active myocardial damage related to systemic diseases, with increased specificity compared with conventional methods, and increased sensitivity in some cases. Further studies are needed to assess the potential value of AM scintigraphy as a therapeutic guide.  (+info)

TY - JOUR. T1 - Connective tissue disease-associated interstitial lung diseases (CTD-ILD) - Report from OMERACT CTD-ILD working group. AU - Khanna, Dinesh. AU - Mittoo, Shikha. AU - Aggarwal, Rohit. AU - Proudman, Susanna M.. AU - Dalbeth, Nicola. AU - Matteson, Eric L.. AU - Brown, Kevin. AU - Flaherty, Kevin. AU - Wells, Athol U.. AU - Seibold, James R.. AU - Strand, Vibeke. N1 - Publisher Copyright: The Journal of Rheumatology Copyright © 2015. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.. PY - 2015/11. Y1 - 2015/11. N2 - Objective. Interstitial lung disease (ILD) is common in connective tissue disease (CTD) and is the leading cause of mortality. Investigators have used certain outcome measures in randomized controlled trials (RCT) in CTD-ILD, but the lack of a systematically developed, CTD-specific index that captures all measures relevant and meaningful to patients with CTD-ILD has left a large and conspicuous gap in CTD-ILD research. Methods. The ...
P1: Possibility when comparing CTD-ILD group and UCTD-ILD group. P2: Possibility when comparing CTD-ILD group and IPF group. P3: Possibility when comparing UCTD-ILD group and IPF group ...
There are complex interactions between connective tissue disease (CTD) and interstitial lung disease (ILD), particularly in the PH patient. Clinicians that care for these patients will benefit from a deeper understanding of CTD and the ILD aspects of this diverse spectrum of disease. There are many clinical dilemmas to address and this course will focus on an approach to the evaluation and management of CTD-associated ILD.
From BioPortfolio: Interstitial lung disease (ILD) is a major pulmonary manifestation of connective tissue disease (CTD), leading to significant morbidity and mortality. Chest hig...
Undifferentiated connective tissue diseases (UCTDs) are clinical entities characterised by signs and symptoms suggestive of a systemic autoimmune disease, which do not fulfil the diagnostic criteria for a defined connective tissue disease. Lung involvement can complicate the course and management of the disease, often determining a worse outcome. Respiratory dysfunction as the first clinical manifestation has seldom been reported. We describe a case of a female patient who developed significant respiratory dysfunction as the principal clinical sign. Video-assisted thoracoscopy was performed and a histological pattern of nonspecific interstitial pneumonia (NSIP) was found. A pathological diagnosis suggested careful follow-up with extensive immunological screening which then detected Raynauds phenomenon and positivity of antinuclear antibodies. After a multidisciplinary discussion (pneumologist, radiologist, pathologist and rheumatologist) a final diagnosis of NSIP associated with UCTD was made. The
What is CTD-ILD? Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a lung disease that may happen to some people with a connective tissue disease.
How undifferentiated connective tissue disease (UCTD) is diagnosed through its symptoms, family history, physical examination, x-rays, and CT scans.
(Update) Donna C: Undifferentiated Connective Tissue Disease (UCTD) For the most part I have still been doing very good. Some little setbacks here and there...
Objective. To review the diagnoses after 5 years in patients who were identified within 12 months of the onset of well established and undifferentiated connective tissue diseases CTD ; to examine death rates and disease remissions in these patients. Methods. This inception cohort of 410 patients was identified in 10 academic rheumatology...
Undifferentiated Connective Tissue Disease stories from our community of patients. Read how these patients from all walks of life got back into their game of life.
Objective: To investigate the timing and complications of lung transplantation for the treatment of connective tissue disease-associated interstitial lung disease (CTD-ILD). Method: The clinical data of connective tissue-associated disease lung transplantation recipients from September, 2015 to February, 2017 were collected. Results: 11 patients with CTD-ILD were evaluated by lung transplantation and were treated with lung transplantation. Including 2 cases dermatomyositis/polymyositis and interstitial lung disease (PM/DM-ILD), 4 cases rheumatoid arthritis and interstitial lung disease (RA-ILD), 4 cases of primary Sjgrens syndrome and interstitial lung disease (pSS-ILD), 1 case of systemic sclerosis and interstitial lung disease (SSc-ILD ...
Dr. Antin-Ozerkis received her Bachelors degree from Princeton University. She went on to complete her medical degree, residency, and fellowship in Pulmonary and Critical Care Medicine at the University of Pennsylvania, where she pursued advanced fellowship training in the evaluation and management of advanced lung disease and lung transplant patients. She came to Yale in 2006. Dr. Antin-Ozerkis is Medical Director of the Yale Interstitial Lung Disease Center of Excellence. Her specific area of clinical expertise is the diagnosis and treatment of interstitial lung diseases (ILD), with a focus on idiopathic pulmonary fibrosis (IPF) and connective tissue disease-associated interstitial lung disease (CTD-ILD). She leads a multidisciplinary group which meets weekly to review patient cases, offering consensus opinions on diagnosis and management. As part of a comprehensive approach to patient care, Yale ILD offers clinical drug trials for patients with IPF and other forms of pulmonary fibrosis. Dr. ...
ICD M30-M36 Systemic connective tissue disorders  autoimmune disease NOS collagen (vascular) disease NOS systemic autoimmune disease systemic collagen
Trigeminal neuralgia - Connective tissue disease Factor. Last reviewed for CCPS 10 March 1995.. Preliminary questions [8154]. 8603 [1] there is some evidence that a connective tissue disease may be a factor in the development of the condition under consideration.. 8184 - the veteran has suffered from a connective tissue disease at some time.. 6563 [2] the veteran has had scleroderma at some time.. or. 8615 [3] the veteran has had Sjogrens syndrome at some time.. or. 2576 [4] the veteran has had systemic lupus erythematosus at some time.. or. [5]8616. the veteran has had dermatomyositis at some time.. or. 8617 [6] the veteran has had mixed connective tissue disease at some time.. 8186 [7] the veteran suffered from the identified illness or injury, a connective tissue disease, prior to the clinical onset of trigeminal neuralgia. [8]. 8187 - the veteran has established the causal connection between the identified illness or injury, a connective tissue disease, and operational service for the ...
Study shows HHV-6 reactivation is disproportionately elevated among patients with autoimmune connective tissue disease. A new study from Italy indicates that HHV-6 reactivation is selectively increased among patients suffering from autoimmune connective tissue diseases (ACTD). Low levels of HHV-6 DNA were detected in the serum of 26% of ACTD patients, which was significantly greater than that observed amongst controls (P , 0.0002). The authors used a highly sensitive assay and the median viral load for these patients was under 100 copies/ml, which would fall below the current level of detection at most clinical laboratories. The group also found a significant association between HHV-6 reactivation and the active disease state for lupus erythematosus (P = 0.021). By contrast, the rate of EBV viremia was similar in patients and controls groups, while CMV, HHV-8, and parvovirus B19 viremia was not detected in any subject.. In the paper, published in the Journal of Medical Virology this month, the ...
This week, I was called to evaluate a young man with several aneurysms (ballooning of his blood vessels) and a dilated (widened) aorta. The medical team thought he had a connective tissue disease because a family member also had a connective tissue disease-she had lupus. Unfortunately, doctors can mean very different things when they talk about a connective tissue disease; this is a common source of confusion for doctors and patients alike. After reading this post, I hope youll be able understand the difference.. Connective tissue is the stuff that holds your body together. That is, the bones, ligaments, tendons, cartilage, fat, and glue that keeps all your organs in place. Two very different types of diseases can affect these tissues-you can have problems in MAKING the connective tissues, or these tissues can be ATTACKED by the bodys own immune system.. In the first type of connective tissue disease, the body is unable to produce strong connective tissues. Its like trying to build ...
Complex Treatment of Children Affected by Undifferentiated Connective Tissue Dysplasia Combined with Bone Mineral Density Reduction
Complex Treatment of Children Affected by Undifferentiated Connective Tissue Dysplasia Combined with Bone Mineral Density Reduction
The conceptual study of connective tissue diseases as one of causative factors in Interstitial lung diseases (ILDs) : both modern and ayurveda perspective ;patients with ILDs come with the onset of progressive exertional dyspnea or a persistent nonproductive cough. Hemoptysis , wheezing and chest pain may be present. Often , the identification of interstitial opacities on chest X-ray focuses the diagnostic approach on one of the ILDs. Rheumatoid arthritis is one of connective and autoimmune diseases which cause ILDs.. inflammation in the air space and alveolar walls and interstitial fibrosis are present due to autoimmunity.. the presence of jts pain , stiffness and deformity like swan neck etc with +ve antinuclear antibodies and anti- immunoglobulin antibodies ( RA factors ) confirm the diagnosis , however these tests are +ve even in absence of defined connective tissue diseases. ILDs are characterized as a significant part of a multiorgan process , as may occur in the connective tissue diseases ...
TY - JOUR. T1 - T cell immunity in connective tissue disease patients targets the RNA binding domain of the U1-70kDa small nuclear ribonucleoprotein. AU - Greidinger, Eric L.. AU - Foecking, Mark F.. AU - Schäfermeyer, Kim R.. AU - Bailey, Craig W.. AU - Primm, Shannon L.. AU - Lee, David R.. AU - Hoffman, Robert W.. PY - 2002/9/15. Y1 - 2002/9/15. N2 - Although the T cell dependence of autoimmune responses in connective tissue diseases has been well established, limited information exists regarding the T cell targeting of self Ags in humans. To characterize the T cell response to a connective tissue disease-associated autoantigen, this study generated T cell clones from patients using a set of peptides encompassing the entire linear sequence of the 70-kDa subunit of U1 snRNP (U1-70kDa) small nuclear ribonucleoprotein. Despite the ability of U1-70kDa to undergo multiple forms of Ag modification that have been correlated with distinct clinical disease phenotypes, a remarkably limited and ...
What exactly is connective tissue disease? Connective tissue diseases are referred to as a group of medical diseases. A connective tissue disease has
A total of 187 specimens from 142 subjects with rheumatoid arthritis, systemic lupus erythematosus, other connective tissue diseases, and controls were placed in cell culture. Specimens from 119 of the subjects grew, lasting over 2 yr in several instances. No evidence of virus infection has been found by a variety of sensitive methods, including cell fusion. Other approaches have likewise failed thus far to implicate any virus in the pathogenesis of rheumatoid arthritis.. ...
Connective tissue diseases by Graham R. V. Hughes; 4 editions; First published in 1977; Subjects: Collagen diseases, Connective Tissue Diseases, Connective Tissue, Diseases, Connective tissues, Internet Archive Wishlist
TY - JOUR. T1 - The short-term role of corticosteroid therapy for pulmonary arterial hypertension associated with connective tissue diseases. T2 - Report of five cases and a literature review. AU - Kato, M.. AU - Kataoka, H.. AU - Odani, T.. AU - Fujieda, Y.. AU - Otomo, Kotaro. AU - Oku, K.. AU - Horita, T.. AU - Yasuda, S.. AU - Atsumi, T.. AU - Ohira, H.. AU - Tsujino, I.. AU - Nishimura, M.. AU - Koike, T.. PY - 2011/10/1. Y1 - 2011/10/1. N2 - Pulmonary arterial hypertension (PAH) is a life-threatening complication in connective tissue diseases (CTD). It remains controversial whether immunosuppressive therapy is useful for PAH associated with CTD (PAH-CTD). The Dana Point algorithm does not refer such treatments in patients with PAH-CTD due to the lack of evidence. However, some case reports have shown the potential efficacy of immunosuppression for PAH-CTD. Here we report five cases of PAH-CTD treated with corticosteroids and discuss the current management of PAH-CTD with immunosuppressive ...
ILD is most commonly found in systemic sclerosis at a prevalence rate of 25% to 90%, Dr. Fischer said. It is also found less frequently in polymyositis and dermatomyositis, RA, Sjögrens syndrome, and systemic lupus erythematosus. If rheumatologists are treating patients with known connective tissue disease, they should take steps to determine if possible ILD is connective tissue disease¬ associated, Dr. Fischer said. Recognition of the exact disease would affect treatment decisions and the prognosis for these patients. Its important for the patients outcome to see where they fit, he said.. ...
Aortic stenosis, hypertrophic obstructive cardiomyopathy, cerebrovascular and cardiovascular diseases (including cerebrovascular insufficiency, coronary heart disease, coronary insufficiency - a risk of excessive blood pressure lowering and concomitant ischemia). Severe autoimmune systemic connective tissue disease (including systemic lupus erythematosus, scleroderma), inhibition of bone marrow hematopoiesis in patients receiving immunosuppressive drugs (increasing the likelihood of neutropenia). Renovascular • Read More ». ...
Garen, Torhild Oddveig; Lerang, Karoline; Hoffmann-Vold, Anna-Maria; Andersson, Anna Helena; Midtvedt, Øyvind; Brunborg, Cathrine; Kilian, Karin Renate; Gudbrandsson, Birgir Mar; Gunnarsson, Ragnar; Norby, Gudrun; Chaudhary, Asad; Thoen, Jørn; Forseth, Karin Maria Øien; Fresjar, Kari; Førre, Øystein Thorleiv; Haugen, Margaretha; Haga, Hans-Jacob; Gran, Jan Tore; Gilboe, Inge-Margrethe; Molberg, Øyvind & Palm, Øyvind (2019). Mortality and causes of death across the systemic connective tissue diseases and the primary systemic vasculitides. Rheumatology. ISSN 1462-0324. 58(2), s 313- 320 . doi: 10.1093/rheumatology/key285 ...
In this study, 82 photomacrographs of nailfold capillary beds from 60 patients with scleroderma spectrum disorders (scleroderma, undifferentiated connective tissue disease, and dermatomyositis) and from 16 normal controls were analyzed blindly, using both semiquantitative and quantitative methods, t …
Results 215 pregnancies in 184 women were included and classified according to mothers autoimmune disease: 52 (24,2%) Primary Antiphospholipid Syndrome (PAPS), 26 (12,1%) with only Antiphospholipid Antibodies (APA), 27 (12,6%) Systemic Erythematosus Lupus (SLE), 28 (13%) SLE with APA, 44 (20,5%) Undifferentiated Connective Tissue Disease (UCTD) and 38 (17,7%) UCTD with APA. A total of 41 (19,06%) miscarriages were reported, 32 (14,8%) in the first 10 weeks of pregnancy and 9 (4.18%) beyond that 10th week. Risk factors for miscarriages in the univariate analysis were mothers age, lupus anticoagulant, IgG and IgM anticardiolipin antibodies, previous miscarriages and PAPS, while UCTD was a protective factor. In the multivariate model only mothers age (OR 0.9, IC 95% 0.8-0.98), lupus anticoagulant (OR 2.5, IC 95% 1.1-5.4), IgG anticardiolipin (OR 4.0, IC 95% 1.8-9.0) and previous miscarriages (OR 2.8, IC 95% 1.2-6.5) were predictors. A Miscarriage Risk Score ranging between 0 and 11 points was ...
Background/Purpose: Patients with Systemic Autoimmune Rheumatic Disease (SARD) often have a prolonged pre-clinical phase during which they are anti-nuclear antibody (ANA) positive but lack clinical symptoms. It has been proposed that progression from asymptomatic autoimmunity to clinical disease is accompanied by immunologic changes that could be used as predictors of disease development. Our objective was to identify cyto/chemokine abnormalities in ANA+individuals who lack sufficient criteria for a diagnosis of SARD. Methods: ANA+ individuals who: 1) lacked clinical symptoms of SARD (ANA No Symptoms, ANS); 2) had a least one clinical symptom of SARD (Undifferentiated Connective Tissue Disease, UCTD); or 3) had a recently diagnosed steroid and immunosuppressive naïve SARD were recruited, and compared with ANA- healthy controls (HC). The levels of 30 cyto/chemokines were measured, 29 by Luminex and one (BAFF) by ELISA. Peripheral blood interferon (IFN)-induced and BAFF gene expression was ...
I lost my Mariel to Interstitial Lung Disease caused by Undifferentiated Connective Tissue Disease. Barely six weeks after we checked with a dermatologist to complain about some ordinary rashes and fever. ( We were even discharged earlier at another hospital for what they thought was merely a viral infection, after ruling out Dengue ). C3…
This multicenter study will attempt to determine the epidemiologic, clinical, serologic and immunogenetic factors associated with patients who develop scleroderma/systemic sclerosis after silicone prosthesis implantation or silicone injection. This will be accomplished by comparing these patients to groups of appropriately matched patients with idiopathic scleroderma/systemic sclerosis without silicone exposure, and appropriately matched volunteers who have received similar silicone implants or injections and have not developed symptoms, physical examination findings, or laboratory abnormalities associated with autoimmune/connective tissue diseases. Patient and physician questionnaires will be self-administered, and will collect data regarding: the number and types of implanted silicone devices or injections; the indications for and nature of the surgical procedures; peri- and post-operative complications; initial and subsequent clinical presentations; and therapy and clinical course of the ...
Non-specific interstitial PNA (NSIP) - basilar-predominant process, ground glass opacities and reticular pattern on imaging, 80% of patients will have fibrotic pattern as well, seen in patients with undifferentiated connective tissue disease, SLE, Sjogrens, Systemic sclerosis, and ...
Hello, I havent posted in a long time - my official diagnosis is undifferentiated connective tissue disease with signed of lupus and Sjögrens syndrome. My last rheumatology check up was almost a...
She has masters degrees in applied, clinical early signs of pregnancy in my dog community ssigns. i want to bookmark everything you ever write. Be sure your schedule is coordinated with other teachers in the school. But the real trouble do a force much larger than they are-one which they cant even pinpoint, and so have little chance to fight. Your babys size may make you feel uncomfortable. Then they were born and their parents wouldnt let you. Plan for some decompression time between conferences. A doctor can sgns you from this requirement. One question that single parents often have is how to make quality time for their children, despite their exhaustion. O quality of education. A recent Consumers Research magazine report on the risk to health from some fluorescent lamps suggested new probes by industry and the government. Your tips are super helpful, thank you. In case undifferentiated connective tissue disease and pregnancy are on the look-out for schools in Punjabi Bagh from the best ...
Background Pulmonary hypertension (PH) can develop in connective tissue disease associated interstitial lung disease (CTD-ILD), and contributes to increased morbidity and mortality. However, except...
Rodriguez et al were the first to report autoantibodies directed against the Golgi complex identified in the serum of a patient with Sjögrens syndrome (SS).1 Since then, several isolated reports have described the presence of anti-Golgi antibodies (AGAs) in several connective tissue diseases (CTDs).1-7 In addition, immunoblotting and immunoprecipitation studies have suggested that there are at least 14 different Golgi complex autoantigens, and their molecular masses range from 35 to 260 kDa.5 However, few reports describe the association between the clinical features of CTD and AGAs. In this letter we present a case of rheumatoid arthritis (RA) associated with AGAs and review several reported cases.. The patient was a woman born in 1939 who developed seropositive RA in 1990. She was admitted to our hospital in March 1998 because of high grade fever, cough, sore throat, chest pain, and severe arthralgia. Systemic laboratory examination disclosed no antinuclear antibody, anti-DNA antibody, or ...
To determine the clinical significance of anticentromere (ACA) and anti Scl-70 antibodies in an English population with connective tissue diseases, we examined the sera of 150 patients, including 40...
Background Interstitial pneumonia in connective tissue diseases (CTD-IP) featuring inflammation and fibrosis is usually a leading cause of death in CTD-IP individuals. by histology, circulation cytometry and molecular biology. Capital t cell subsets included in the procedure of CTD-IP had been described, while the regulatory features of MSCs separated from the bone tissue marrow of regular people (HBMSCs) on cytotoxic Capital t cells and CTD-UIP HLFs had been looked into in vitro. Outcomes Higher frequencies of cytotoxic Capital t cells had been noticed in the lung and peripheral bloodstream of CTD-IP individuals, followed with a decreased regulatory Capital t cell (Treg) level. CTD-UIP HLFs secreted proinflammatory cytokines in mixture with upregulation of -clean muscle mass actin (-SMA). The addition of HBMSCs in vitro improved Tregs SC-514 concomitant with decreased cytotoxic Capital t cells in an fresh cell model with prominent cytotoxic Capital t cells, and advertised Tregs growth in ...
WHO Group 1 PH (PAH, pulmonary arterial hypertension) is a progressive and chronic disease. There currently is no cure. In PAH, the arteries in the lungs become narrow, thickened or stiff, which causes high blood pressure in the lungs. The disease can present in several forms, one of which is PAH associated with connective tissue disease (CTD-PAH), such as scleroderma, CREST syndrome and lupus. Research has found that this particular form of PAH is difficult to treat and patients have worse outcomes compared to people with other types of PAH. Two groups of researchers looked at different approaches to treating CTD-PAH using PH-targeted medications.. Selexipag therapy. The European Respiratory Journal published the findings of one study on the use of selexipag (Uptravi®) in patients with CTD-PAH. (https://www.ncbi.nlm.nih.gov/pubmed/28818881) Sean Gaine, M.D. - National Pulmonary Hypertension Unit, Mater Misericordiae University Hospital in Dublin - led an international team of researchers to ...
Background: Connective tissue disease (CTD) is a group of inflammatory disorders of unknown aetiology. Patients with CID often report hypersensitivity to nickel. We examined the frequency of delayed type hypersensitivity (DTH) (Type IV allergy) to metals in patients with CTD. Methods: Thirty-eight patients; 9 with systemic lupus erythematosus (SLE), 16 with rheumatoid arthritis (RA), and 13 with Sjogrens syndrome (SS) and a control group of 43 healthy age- and sex-matched subjects were included in the study. A detailed metal exposure history was collected by questionnaire. Metal hypersensitivity was evaluated using the optimised lymphocyte transformation test LTT-MELISA (R) (Memory Lymphocyte Immuno Stimulation Assay). Results: In all subjects, the main source of metal exposure was dental metal restorations. The majority of patients (87%) had a positive lymphocyte reaction to at least one metal and 63% reacted to two or more metals tested. Within the control group, 43% of healthy subjects ...
This ACD course teaches, from a dermatological perspective, about the most commonly encountered Connective Tissue Disease including autoimmune disorders such as Lupus, Dermatomyositis and Scleroderma.
This article reviews the associations of occupational and environmental exposures relevant to connective tissue diseases, and in particular systemic sclerosis.
This article will inform you about lupus and connective tissue disease as well as other similar disorders that are interconnected with the disease.
Connective tissue diseases are generally rare with varying prevalence. Accurate diagnosis and specialist care are key to proper management.
Uveitis Caused by Connective Tissue Disease - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.
Get to know the muscle and connective tissue diseases and learn more about lipoma, fibroids and duchenne muscular dystrophy. Epidemiology and clinical presentation of soft tissue pathology ✓, treatment of primary systemic amyloidosis ✓, myoma and myosarcoma ✓. Read more here!
University of Minnesota Health physicians are available to help you with some of the most advanced treatments to relieve pain from connective tissue disease and improve your quality of life.
undifferentiated connective tissue disease answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Definition of mixed connective tissue diseases in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is mixed connective tissue diseases? Meaning of mixed connective tissue diseases as a legal term. What does mixed connective tissue diseases mean in law?
TY - JOUR. T1 - Secretory Diarrhea in Mixed Connective Tissue Disease. AU - Thiele, Dwain L. AU - Krejs, G. J.. N1 - Copyright: Copyright 2016 Elsevier B.V., All rights reserved.. PY - 1985/2. Y1 - 1985/2. N2 - Intractable diarrhea of 2 years duration was evaluated in a patient with mixed connective tissue disease and dilatation of the proximal small bowel. Stool analysis revealed secretory diarrhea. Intestinal perfusion studies showed that the jejunum was secreting water and electrolytes. Chloride and bicarbonate secretion against an electrical gradient suggested active anion secretion. Absorption in the ileum was normal. No evidence for bacterial colonization of the small bowel, protein‐losing enteropathy, or a hormonal cause of intestinal secretion could be found. This case report suggests that water and electrolyte secretion in dilated segments of small bowel may be another cause of diarrhea in cases of gastrointestinal involvement by systemic connective tissue disease.. AB - Intractable ...
Looking for online definition of connective tissue diseases in the Medical Dictionary? connective tissue diseases explanation free. What is connective tissue diseases? Meaning of connective tissue diseases medical term. What does connective tissue diseases mean?
TY - JOUR. T1 - Mixed connective tissue disease. AU - Hoffman, Robert W.. AU - Greidinger, Eric L.. PY - 2000. Y1 - 2000. N2 - A defining feature of mixed connective tissue disease (MCTD) is the presence of antibodies against the U1-ribonucleoprotein (RNP) complex, but other autoantibodies in MCTD have recently been described. Research has also further elucidated the immune responses directed against U1-RNP in humans and in murine models of disease. Hypotheses implicating modified self-antigens and/or infectious agents in the pathogenesis of MCTD have been advanced. Links between the immunologic and clinical phenomena in MCTD are emerging. Longitudinal study of patients with MCTD highlights the impact of pulmonary hypertension on disease outcome. (C) 2000 Lippincott Williams and Wilkins, Inc.. AB - A defining feature of mixed connective tissue disease (MCTD) is the presence of antibodies against the U1-ribonucleoprotein (RNP) complex, but other autoantibodies in MCTD have recently been ...
It is often several years before sufficient signs and symptoms appear to make the diagnosis of MCTD, relative to the more sequential clinical manifestations of SLE, scleroderma, and polymyositis, so often, in the initial phases, the diagnosis most appropriate for patients is undifferentiated connective tissue disease.[19] If the patient has edematous hands and/or swollen fingers in conjunction with elevated titers of antinuclear antibodies, an elevated titre of anti-U1 RNP antibody is a good predictor of progressing to MCTD.[20] The presence of this specific antibody is sine qua non for the diagnosis of MCTD,[19] although its isolated presence does not guarantee that a patient has MCTD or will develop it. If the dominant autoantibodies are antiDNAn, Sm, Scl70 or Ro, it is likely the patient will develop another connective disease distinct from MCTD. The clinical manifestations of MCTD appear correlated more intensely to the antibodies against protein A and 68 kD of the U1 RNP complex. The ...
People with mixed connective tissue disease (MCTD) have systemic lupus erythematosus, scleroderma, and polymyositis. Get information on mixed connective tissue disease (MCTD) symptoms, types, treatment, and prognosis.
Best Treatments for Mixed connective tissue disease in Pune : Find Best Doctors, Book Appointment, Call Now, Get Address & numbers of Best Treatments for Mixed connective tissue disease in Pune
Individuals with mixed connective tissue disease have symptoms that overlap with those of two or more connective tissue diseases. These diseases include systemic lupus erythematosus, polymyositis, scleroderma, and rheumatoid arthritis. (For more information on these disorders, see the Related Disorders section of this report.). A condition known as Raynauds phenomenon may precede the development of additional symptoms of MCTD. Raynauds phenomenon, which is seen also in scleroderma, is characterized by painfully cold fingers and toes with blue and/or white color changes caused by spasm of blood vessels in the hands and feet in response to cold or stress. It occurs in approximately 90 percent of individuals with MCTD.. Pain in multiple joints (polyarthralgia) or inflammation of joints (arthritis) also occurs in the majority of affected individuals. Lupus-like skin inflammation in sun-exposed areas and hair loss are common, as are skin scarring changes on the fingers and face like those seen in ...
is a systemic connective tissue disease characterized by the variable association of cardiovascular, musculoskeletal, ocular, and pulmonary symptoms.
TY - JOUR. T1 - Clinical significance of antibodies to a 68 kDa U1RNP polypeptide in connective tissue disease. AU - McHugh, N. AU - James, I. AU - Maddison, P. PY - 1990. Y1 - 1990. N2 - In a series of 163 patients with systemic lupus erythematosus (SLE) and/or systemic sclerosis and/or mixed connective tissue disease (MCTD), the presence of antibodies to a 68 kDa U1RNP associated polypeptide was more predictive for SLE (88%) than for MCTD (38-68%) using 3 different sets of proposed criteria for the latter condition. In all but one case studied serially the immunoblotting profile remained constant. In SLE recognition of the 68 kDa polypeptide identified a subset with increased vasoreactivity with Raynauds phenomenon (96%, p less than 0.001) and swollen fingers (68%, p less than 0.001) whereas recognition of a 47 kDa La (SSB) polypeptide was associated with photosensitivity (72%, p less than 0.02), less renal involvement (p less than 0.05) and an older age of disease onset (46.6 years +/- 18.3 ...
This dissertation describes the results of a population-based case-control study of risk factors for five connective tissue diseases: systemic lupus erythematosus, Sjogrens syndrome, systemic sclerosis/CREST syndrome, polymyositis/dermatomyositis and mixed connective tissue disease.Cases were female residents of King County, Washington who were diagnosed by a rheumatologist between January 1, 1983 and December 31, 1991 as having a disease of interest. Two control groups were used. The new control group was identified by random digit telephone dialing and was frequency matched to the case group on age at diagnosis and calendar year of diagnosis. Mailed questionnaires were used for concurrent data collection on the cases and on the new control group, with a telephone administered questionnaire for non-respondents. The pre-existing control group had been used for three other epidemiologic studies, and was identified and had in-person interviews before 1992, when mass media attention to the ...
This is a photo of a finger ulcer caused by secondary Raynauds phenomenon in a patient with mixed connective tissue disease (MCTD). The MCTD developed after thyroidectomy.
Test for mixed connective tissue disease, an autoimmune disease often referred to as overlap syndrome. RNP antibodies found in 95-100% MCTD patients
Mixed Connective Tissue Disease (MCTD) - Learn about the causes, symptoms, diagnosis & treatment from the Merck Manuals - Medical Consumer Version.
Statement of Intent. MCTDfoundation.org is a non-profit, online gathering place, for those living with the Mixed Connective Tissue Disease (MCTD), their friends, families, support systems and medical providers.. We strive to present the most current information available on the overlap autoimmune diseases that comprise MCTD, as well as available treatment options.. We sell MCTD awareness merchandise as a fundraising mechanism to ensure the future of the site, as well as providing educational materials.. We provide forums for those afflicted, as well as blog formatted personal stories of those who care to share their personal journey with the disease. Only when we can share symptoms and histories can we start to identify commonalities. As appropriate, photographs of symptoms will also be filed.. An important aspect to be covered on the website is the impact of the Autoimmune Protocol Paleo diet, one of the clean eating plans that has helped modify the disease process for many patients.. Our ...
Tiddens HA, van der Net JJ, de Graeff-Meeder ER, Fiselier TJ, de Rooij DJ, van Luijk WH, Herzberger R, van Suijlekom LW, van Venrooij WJ, Zegers BJ, et al. Juvenile-onset mixed connective tissue disease: longitudinal follow-up. J Pediatr. 1993 Feb;122(2):191-7. [Medline]. ...
Still, they mean well, dont they? So I should accept their advice with grace and just move on. Shouldnt I?. Maybe yes, maybe no. How will they learn what inflammatory arthritis, rheumatoid arthritis, mixed connective tissue disease, lupus, spondylitis…how will they ever know what these diseases really are and how they affect my life, if I dont educate them?. But educating gets tiring. Its hard work raising awareness, one person at a time. So sometimes I just have a giggle at the weird and wonderful (and conflicting) advice I receive regularly. Sometimes totally opposing advice, from the same person within a few days.. Heres a sample…. You just need to push through the pain! You need to develop a higher pain tolerance!. You should rest more. The pain is telling you to rest your body. If you rest more, youll be fine.. Try eating this. Its an anti-inflammatory super food. (Regardless of the fact that I eat it all the time). Dont EVER eat this! Not ever. Its the cause of all your ...
The paper outlines the experience with minimally invasive surgical technologies for esophageal injury in the presence of systemic connective tissue disease. The clinical example clearly demonstrates the importance of timely diagnosis of esophageal stricture in CREST syndrome and suggests that it is necessary to treat these difficult-to-treat patients at large multiprofile hospitals ...
Mixed connective tissue disease is a rare autoimmune disorder featuring signs and symptoms of three different disorders: lupus, scleroderma and polymyositis.
Patients with juvenile mixed connective tissue disease had impaired left and right ventricular function compared with matched controls after a median of 15 years disease duration.
I have a mixed connective tissue disease that does not currently have a name. I was tested for marfans syndrome and it was negitative, but did show a gene mutation. It just wasnt a recognized one. My immediate family was tested at John Hopkins for ehlers danlos syndrome but it was negitative but also showed a gene malformation. They sent my family home with tons of information on eds because even though we dont have that exact kind it is very similar to it. Anybody else have this problem? My medical problems are extensive and it seems its hit or miss in my family as far as severity!! Any help would be appreciated. Thank you ...
There are a few tips, however, that can make a huge difference during a pregnancy. Staying healthy and fit during pregnancy should be a womans prime concern. Hi Bettany, wish you luck and also remember to consult your doctor instead of relying on self-diagnoses, Take care. I had to have extra appointments at the hospital to have my airways measured incase I need an emergency general aneasthetic. Turns out, the Alaska Business Journal is in a couple of electronic databases that most libraries should have. Nothing against doctors, Western Medicine, or advice from fertility experts, but theres one thing they always miss-something that I call the missing link. Thats the only way to know for sure. THURSDAY (Jupiter): you are polite, considerate, and soft-spoken. The female must not indulge in strenuous exercise. Your doctor may want to confirm the pregnancy with an in office test but mixed connective tissue disease and pregnancy are basically the same as the home tests. The second phase is called ...
Mixed connective tissue disease has signs and symptoms of multiple disorders, making it difficult to diagnose. Theres no cure, but medications can help.
Mixed connective tissue disease patients can claim disability benefits as it is considered as a disability. Read on to know more.
Overview of Mixed connective tissue disease as a medical condition including introduction, prevalence, prognosis, profile, symptoms, diagnosis, misdiagnosis, and treatment
Learn about Mixed connective tissue disease. What are the symptoms, the causes and how to treat this condition? What can we do to cope and prevent it...
Hedayati H, Kloetzli N. Mixed connective tissue disease: report of a case with fatal outcome. J Am Osteopath Assoc 1987;87(9):622. doi: https://doi.org/10.7556/jaoa.1987.87.9.622.. Download citation file:. ...
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Ceftriaxone therapy of chronic inflammatory arthritis. A double-blind placebo controlled trial. Arch Intern Med. 1990 Aug;150(8):1677-82.. In a placebo-controlled, double-blind study of 60 patients with inflammatory arthritis - rheumatoid arthritis (RA), psoriatic arthritis (PsA), vasculitis, and undifferentiated connective tissue disease (UCTD) - who were positive for Lyme disease (borrelia burgdorferi), patients were randomized to be in one of two study arms to either receive an inactive placebo or the antibiotic, ceftriaxone, 2 grams/day, intravenously for 2 weeks. Nearly half of the antibiotic group (19/40 patients) experienced improvement as compared with the placebo group (2/20 patients), who were later able to elect to receive ceftriaxone therapy. Of 58 patients who were treated with IV ceftriaxone, 27 were notably improved at follow-up, 13-24 months later, and responses were seen in all forms of arthritis (RA 5/12, PsA 5/8, vasculitis 3/5, and UCTD 14/33). Of these 27 patients, 16 ...
TY - JOUR. T1 - Peripheral sensorimotor and autonomic neuropathy associated with systemic lupus erythematosus. T2 - Clinical, pathological and immunological features. AU - Mccombe, P. A.. AU - Mcleod, J. G.. AU - Pollard, J. D.. AU - Guo, Y. P.. AU - Ingall, T. J.. PY - 1987/4. Y1 - 1987/4. N2 - The clinical features and pathological findings in the sural nerves are described of 7 patients with peripheral neuropathy; in 4 cases the criteria for diagnosis of systemic lupus erythematosus (SLE) were satisfied and in 3 other cases there was serological evidence of an undifferentiated connective tissue disease, most probably SLE. The peripheral neuropathy was of a chronic sensorimotor type with predominantly sensory features and gradual onset. In 2 cases the presentation was asymmetric. One patient had autonomic dysfunction. The pathological findings in the biopsied sural nerves were those of axonal degeneration and vasculitis. In 6 nerves there was increased expression of Class II (Ia) antigen ...
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Background and objectives: The overlap between antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (ANCA-GN) and connective tissue diseases (CTD) has been reported mainly as case series in the literature. Frequency of this association, as well as presentation and outcomes are unknown. Materials and Methods: Patients from the Maine-Anjou ANCA-associated vasculitides (AAV) registry with ANCA-GN diagnosed between 01/01/2000 and 01/01/2018, ANCA positivity, and at least six months of follow-up, were included. Results: 106 out of 142 patients fulfilled the inclusion criteria and were analyzed. CTD was present at ANCA-GN diagnosis in 16 (15.1%) patients. The most common CTD were rheumatoid arthritis, Sjogren syndrome and systemic sclerosis. Compared to the control group, females were more represented in the CTD group (75%, p = 0.001). Renal presentation was comparable between groups, including the pathological analysis of renal biopsies. Patients of CTD group presented a higher rate of
NIH Rare Diseases : 50 arterial tortuosity syndrome is a disorder that affects connective tissue (a tissue that provides strength and flexibility to structures throughout the body). it is characterized by blood vessel abnormalities, particularly abnormal twists and turns (tortuosity) of the blood vessels that carry blood from the heart to the rest of the body (the arteries). other blood vessel abnormalities that may occur in this disorder include constriction (stenosis) and abnormal bulging (aneurysm) of vessels, as well as small clusters of enlarged blood vessels just under the skin (telangiectasia). other features include: joints that are either loose and very flexible (hypermobile) or that have deformities limiting movement (contractures) soft and stretchable skin long, slender fingers and toes (arachnodactyly) curvature of the spine (scoliosis) sunken chest (pectus excavatum) or protruding chest (pectus carinatum) protrusion of organs through gaps in muscles (hernias) elongation of the ...
Connective Tissue Disorder and Disability: undifferentiated or mixed connective tissue disease may qualify for disability if you are unable to work
Osteogenesis imperfecta (OI) is a systemic connective tissue disorder most often caused by mutations in collagen type 1 related genes. Patients with OI suffer from multiple fractures and various...
Hereditary progressive arthro-ophthalmopathy definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
A diagnosis can be difficult to make because the three conditions (SLE, scleroderma, and polymyositis) that can be seen in MCTD usually occur one after the other over a long period of time, rather than at the same time. It may take several years to make an accurate diagnosis of MCTD.. There are four features that point to MCTD rather than another connective tissue disorder:. ...
In general, use of ACE inhibitors significantly reduced the development of proteinuria and/or biopsy-proven lupus nephritis and was associated with a decreased risk of disease activity [86]. Concomitant use of antimalarial drugs (chloroquine and hydroxychloroquine) at diagnosis of lupus nephritis reduced the risk of progression to end-stage renal failure and frequency of hypertension [87].. Specific treatment follows the class of lupus nephritis, which is defined by the revised ISN criteria. Class I and class II require no therapy directed at the kidney in consequence of good long-term renal outcome [88]. In contrast, high-dose steroid therapy rapidly resolved nephrotic syndrome in a majority of SLE patients with minimal change disease either in the absence or with underlying class II lupus nephritis based on renal biopsy findings [82, 83]. Immunosuppressive treatment is required in the management of class III (focal), class IV (diffuse) and class V (membranous nephropathy) lupus nephritis and ...
Heritable connective tissue diseases comprise a heterogeneous group of multisystemic disorders that are characterized by significant morbidity and mortality. These disorders do not merely result from defects in the amount or structure of one of the components of the extracellular matrix, as the extracellular matrix also serves other functions, including sequestration of cytokines, such as transforming growth factor beta (TGFβ). Indeed, disturbed TGFβ signaling was demonstrated in several heritable connective tissue diseases, including syndromic forms such as Marfan or Loeys-Dietz syndrome and non-syndromic presentations of thoracic aortic aneurysm/dissection. Because of these findings, new therapeutic targets have been unveiled, leading to the initiation of large clinical trials with angiotensin II type 1 receptor antagonists that also have an inhibiting effect on TGFβ signaling. Here, we present an overview of the clinical characteristics, the molecular findings, and the therapeutic ...
Clinical trial for SYSTEMIC LUPUS ERYTHEMATOSUS | Connective Tissue Diseases | Autoimmune disease | Dermatomyositis (Connective Tissue Disease) | Lupus Nephritis | CONNECTIVE TISSUE DISEASE | Glomerulonephritis , A Study of KZR-616 in Patients With SLE With and Without Lupus Nephritis
Results. In the group of patients with Raynauds phenomenon mean serum concentration of ET-1, TNF-α, PF-4, and vWF was significantly greater than in the healthy group. In contrast, serum IL-6 and IL-6sR concentrations did not differ significantly between the diseased and healthy groups. In a subgroup of Raynauds phenomenon patients showing particularly high concentration of serum ET-1 (twice as much as mean control concentration), the increase in IL-6, IL-6sR, vWF and c-ANCA concentration exhibited statistical significance in comparison with patients with lower serum ET-1 concentration. The vWF concentration exhibited positive correlation with time interval between the occurrence of clinical symptoms and serum ANA antibodies concentration. The increase in ET-1 synthesis in Raynauds phenomenon patients is dependent on the increase in IL-6 level and c-ANCA antibodies level ...
Reversible vasospasm of the extremities occurs as an isolated symptom in the absence of underlying disease (primary Raynaud phenomenon) or in association with other disorders (secondary Raynaud phenomenon). It has been reported that Raynaud phenomenon is associated with connective tissue diseases, but the frequency and types of diseases that eventually develop are not well established. Spencer-Green conducted a systematic literature search to assess the rates and predictors of transition to secondary disease after a primary diagnosis of Raynaud phenomenon.. A total of 639 patients with primary Raynaud phenomenon were identified from 10 studies. The average length of study follow-up was four years. The average duration of Raynaud phenomenon in the study subjects was 12.3 years. During follow-up, 12.6 percent (81 patients) developed a secondary disorder. Eighty of these cases were connective tissue diseases. Two thirds of the cases of connective tissue disease were attributed to systemic ...
The fact is that biology doesnt conform well to hard and fast rules. The immune system is particularly difficult this way; I used to tell my undergraduate immunology students that every rule they learned in class would have an exception somewhere. Since the immune system itself doesnt follow strict rules, it should come as no great surprise that autoimmune diseases dont either. I regard autoimmune diseases as being points on a continuum, rather than existing as discrete entities. These diseases all share in common the fact that the immune system has lost the ability to tell whether various tissues in the body are part of the body or whether they are invading germs. Specific autoimmune diseases are diagnosed depending on which parts of the body are being attacked, and by which parts of the immune system are doing the attacking ...
For a long time before diagnosis I began to lose strength, I had mentioned in passing at a number of doctors appointments but it was never the main reason for my visit. As I was living quite a sedentary lifestyle it was attributed to this. Once I changed jobs to a more computer based role I started to notice pain in my wrist and fingers. I visited the doctors and they suggested it was a form of repetitive strain injury, tendonitis. At the end of 2014 I was lucky enough to go on a 3 week holiday where I still experienced the pain in my joints and fatigue which could no longer be attributed to work. When I got back home I visited the doctor who booked me in for a blood test and referred me to a rheumatologist. The first one I saw was absolutely useless but the rheumatology nurse was still concerned with my results and escalated it to the consultants meeting. Following the meeting I was called back to the hospital by my current consultant who booked me in for a load of tests (blood work, CT scan, ...
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Mixed connective tissue disease - Mixed connective-tissue disease (MCTD) is a disorder in which features of various connective- ... A connective tissue disease (collagenosis) is any disease that has the connective tissues of the body as a target of pathology ... Undifferentiated connective tissue disease (UCTD) is a disease in which the body mistakenly attacks its own tissues. It is ... Merck Manual: Musculoskeletal and connective tissue disorders Merck Manual: Inherited connective tissue disorders Arthritis ...
Autoimmune diseases, Connective tissue diseases, Systemic connective tissue disorders). ... Undifferentiated connective tissue disease (UCTD) is a disease in which the body mistakenly attacks its own tissues. It is ... June 2011). "Undifferentiated connective tissue disease presenting with prevalent interstitial lung disease: Case report and ... Mixed connective tissue disease". In George C. Tsokos (ed.). Modern Therapeutics in Rheumatic Diseases. Humana Press. pp. 347- ...
"Mixed Connective Tissue Disease, MCTD". The Free Dictionary by Farlex. Nevares AM, Larner R. "Mixed Connective Tissue Disease ( ... "Definition and diagnosis of mixed connective tissue disease". Alves, Marta (2020). ""Mixed connective tissue disease": a ... "Mixed Connective Tissue Disease (MCTD)". MedicineNet.com. Nevares AM, Larner R. "Mixed Connective Tissue Disease (MCTD): ... Connective tissue diseases, Disorders of fascia, Systemic connective tissue disorders, Autoimmune diseases). ...
710 Diffuse diseases of connective tissue 710.0 Systemic lupus erythematosus 710.2 Sjögren's syndrome 710.3 Dermatomyositis ... Diseases of the Musculoskeletal System and Connective Tissue. It covers ICD codes 710 to 739. The full chapter can be found on ... 710.4 Polymyositis 710.5 Eosinophilia myalgia syndrome 710.9 Connective tissue disease, unspec. 711 Arthropathy associated with ... 727.03 Trigger finger, acquired 727.04 de Quervain's disease 727.05 Tenosynovitis, hand/wrist 727.06 Tenosynovitis, foot/ankle ...
Rheumatoid arthritis Sjögren's syndrome Dermatomyositis Polymyositis Mixed connective tissue disease Cold agglutinin disease ... "Connective Tissue Diseases". Rheumatology. London: Manson Publishing. p. 117. ISBN 978-1-84076-173-3. Smith CR, Rodeheffer RJ ( ... Secondary Raynaud's can occur due to a connective-tissue disorder such as scleroderma or lupus, injuries to the hands, ... Nail fold capillary examination or "capillaroscopy" is one of the most sensitive methods to diagnose RS with connective tissue ...
In addition to SLE, these antibodies are highly associated with mixed connective tissue disease. Anti-nRNP antibodies recognise ... They are highly associated with polymyositis and dermatomyositis, and are rarely found in other connective tissue diseases. ... A significant number of patients are diagnosed as systemic lupus erythematosus or undifferentiated connective tissue disease ... Venables PJ (2006). "Mixed connective tissue disease". Lupus. 15 (3): 132-7. doi:10.1191/0961203306lu2283rr. PMID 16634365. ...
"Mixed Connective Tissue Disease (MCTD) , Cleveland Clinic". my.clevelandclinic.org. Retrieved 2016-11-07. Ruigrok, Rob WH; ... Anti-RNP antibodies are autoantibodies associated with mixed connective tissue disease and are also detected in nearly 40% of ... "RNA-binding proteins in human genetic disease". Trends in Genetics. 24 (8): 416-425. doi:10.1016/j.tig.2008.05.004. ISSN 0168- ...
Autoimmune Mixed connective tissue disease Maddison PJ (December 1991). "Overlap syndromes and mixed connective tissue disease ... Examples of overlap syndromes in rheumatology include mixed connective tissue disease and scleromyositis. Diagnosis depends on ... "Overlap connective tissue disease syndromes". Autoimmunity Reviews. 12 (3): 363-73. doi:10.1016/j.autrev.2012.06.004. PMID ... Examples of overlap syndromes can be found in many medical specialties such as overlapping connective tissue disorders in ...
Hohenstein, B.; Bornstein, S.R.; Aringer, M. (2013). "Immunoadsorption for connective tissue disease". Atherosclerosis ... Immunoadsorption could be used in various autoimmune-mediated neurological diseases in order to remove autoimmune antibodies ... "Safety and Tolerability of Plasma Exchange and Immunoadsorption in Neuroinflammatory Diseases". Journal of Clinical Medicine. 9 ...
Neurological manifestations of connective tissue disease. Neurol Clinics 2002;20:151-178. "RR&D Brain Rehabilitation Research ... and neurological manifestations of vasculitis and connective tissue disease. He has been the medical director of two VA Office ...
Trozak D, Gould W (1984). "Cocaine abuse and connective tissue disease". J Am Acad Dermatol. 10 (3): 525. doi:10.1016/S0190- ... Moore PM, Richardson B (1998). "Neurology of the vasculitides and connective tissue diseases". J. Neurol. Neurosurg. Psychiatry ... and pathological restricting of lung tissue. Cocaine may also increase risk for autoimmune disease and damage nasal cartilage. ... Moderate coffee consumption may decrease the risk of cardiovascular disease, and it may somewhat reduce the risk of type 2 ...
Autoimmune diseases, Systemic connective tissue disorders). ... Systemic vasculitides are a group of heterogeneous diseases ... Some examples of this group include granulomatosis with polyangiitis, polyarteritis nodosa, Behçet's disease, and HSP. Gonzalez ...
Connective tissue components of Peyronie's disease plaque. Abstract 748. Journal of Urology 163:169, 2000 7. Michael Shaw, Lev ... Peyronie's Disease and its Medical Management in Male Infertility and Sexual Dysfunction. Wayne J.G Hellstrom editor. Springer- ...
Halper J (2014). "Proteoglycans and diseases of soft tissues". Progress in Heritable Soft Connective Tissue Diseases. Adv. Exp ... and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells". The ... Molecular Basis of Disease. 1406 (2): 203-13. doi:10.1016/S0925-4439(98)00005-2. PMID 9573366. Font B, Eichenberger D, ... so non-glycated forms of fibromodulin can accumulate in tissues such as cartilage. Fibromodulin is found in the epidermis of ...
Progress in Heritable Soft Connective Tissue Diseases. Advances in Experimental Medicine and Biology. Vol. 802. pp. 201-30. doi ... In menopausal endometrial tissue, the level of lumican expression decreases and is also low in pathological compared to normal ... Lumican is present in the extracellular matrix of uteral tissues in fertile women. There is an increase of lumican during the ... Lum knockout mice also have abnormal collagen in their heart tissue, with fewer and thicker fibrils. Mice deficient in both ...
AD is more common in those with a history of high blood pressure; a number of connective tissue diseases that affect blood ... Progress in Heritable Soft Connective Tissue Diseases. Advances in Experimental Medicine and Biology. Vol. 802. pp. 77-94. doi: ... Repair may be recommended when greater than 4.5 cm (1.8 in) in size if the person has one of the several connective-tissue ... Aortic dissection is associated with hypertension (high blood pressure) and many connective tissue disorders. Vasculitis ( ...
They may be associated with connective tissue diseases. The sign is named after the dermatologist Irwin M. Braverman. Patel, ... Skin signs of systemic disease. New York: Elsevier; 2008. ISBN 9780721637457 Patel LM, Lambert PJ, Gagna CE, Maghari A, Lambert ... Laju M.; Lambert, Phelps J.; Gagna, Claude E.; Maghari, Amin; Lambert, W. Clark (2011). "Cutaneous signs of systemic disease". ... WC (2011). "Cutaneous signs of systemic disease". Clin. Dermatol. 29 (5): 511-22. doi:10.1016/j.clindermatol.2011.01.019. PMID ...
Parish JG (1967). "Skeletal hand charts in inherited connective tissue disease". Journal of Medical Genetics. 4 (4): 227-38. ...
Marfan syndrome Connective tissue disease "How We Help". The Marfan Foundation. Retrieved 2014-09-14. "Celebrate National ... of saving lives and improving the quality of life for people affected by the condition which is a genetic connective tissue ... "Walk for Victory at TeWinkle Park to honor Rare Disease Day". Daily Pilot. 2020-02-29. Retrieved 2020-09-08. Official website ...
50mm and connective tissue disease Ascending aortic aneurysm > 50mm and risk factors and connective tissue disease The goal of ... Cusp tissue is resected where it is grossly abnormal. Using patch tissue, the cusps are enlarged so they reach the second (new ... Tissue of the aortic valve is removed or detached from the aorta in places where it is clearly abnormal. The location of a ... Tissue redundancy through stretching is corrected by sutures. The unicuspid aortic valve may not only result in relevant ...
... is a skin and connective tissue disease. It is a form of lower extremity panniculitis, an inflammation of ... Fibrotic tissue may predispose the tissue to ulceration. Recurrent ulceration and fat necrosis is associated with ... Sleisenger & Fordtran's Gastrointestinal and Liver Disease, 7th ed . In: . Diseases of the mesentery and omentum. Philadelphia ... Venous disease, such as venous incompetence, venous hypertension, and body mass (obesity) may be relevant to the underlying ...
August 1988). "An inherited connective tissue disease in the horse". Laboratory Investigation. 59 (2): 253-62. PMID 3404977. ... Managed breeding strategy is currently the only option for reducing the incidence of the disease. The disease is found ... is an inherited autosomal recessive connective tissue disorder. It develops from a homozygous recessive mutation that weakens ... The disease first was recognized in 1971. Research of affected animals indicated that 95% of the identified HERDA horses have ...
"IgG4-Related Disease - Musculoskeletal and Connective Tissue Disorders". Merck Manuals Professional Edition. Retrieved 20 July ... Celiac disease: Celiac disease is an autoimmune condition that causes inflammation in the small intestine after gluten is eaten ... For example, if a rectal remnant remains, UC disease can be retained in the small remnant. Active disease feels similar to ... or cancer patients retain disease in the anal canal to remove all remaining disease. When a hand sewn anastomosis is preformed ...
An inherited connective tissue disease in the horse. Kadash, Kathy "Poco Bueno: Preserving the Past for the Future" Western ... Poco Bueno is the stallion that is linked to the genetic disease Hereditary Equine Regional Dermal Asthenia (HERDA) in stock ...
"Mixed connective tissue disease presenting as trigeminal neuropathy". Postgrad Med J. 58 (678): 237-238. doi:10.1136/pgmj. ... Later in his career he became interested in the role of trace elements in the causation of neurological disease, delivering the ...
Common causes include autoimmune diseases and connective tissue diseases. Diagnosis of DAH is often given following observation ... Park, Moo Suk (April 2013). "Diffuse Alveolar Hemorrhage". Tuberculosis and Respiratory Diseases. 74 (4): 151-62. doi:10.4046/ ...
2008). "Vitamin D deficiency in undifferentiated connective tissue disease". Arthritis Res. Ther. 10 (5): R123. doi:10.1186/ ...
The term may sometimes also characterize connective tissue disease. A disseminated infection, for example, has extended beyond ... Disseminated disease refers to a diffuse disease-process, generally either infectious or neoplastic. ... Disseminated disease is often contrasted with localized disease. v t e (Articles lacking sources from July 2018, All articles ... lacking sources, Diseases and disorders, Medical terminology, All stub articles, Disease stubs). ...
... hematologic and neoplastic diseases such as leukemia or bony tumors; and other connective tissue diseases (such as systemic ... Rarely, metabolic diseases, such as Farber disease may also mimic JIA. Patients with Farber disease typically have subcutaneous ... Connective tissue diseases, Inflammatory polyarthropathies, Idiopathic diseases). ... The disease appears to be more common in girls, and is most common in Caucasians. The cause of JIA, as the word "idiopathic" ...
A connective tissue disease has been suspected in some cases. Autoimmunity may have something to do with it, as 25% of all ... Watermelon disease was first diagnosed by Wheeler et al. in 1979, and definitively described in four living patients by Jabbari ... Some of the discussed modalities have been used in GAVE patients with another underlying disease rather than SSc; they are ... The Genetic and Rare Diseases Information Center (GARD) states that pernicious anemia is one of the conditions associated with ...
... can also present in the setting of nontraumatic inflammatory injury of auricular connective tissue such as in ... Diseases of the ear and mastoid process, Ear, Skin conditions resulting from physical factors, Sports injuries, Martial arts ... Consequently, the concave pinna fills with disorganized connective tissue. The cartilage then deforms and kinks, resulting in ... Risk of necrotic tissue is greatest when both posterior and anterior surfaces are involved, although posterior surface ...
Peritendinous tissues become macroscopically thickened and new connective tissue adhesions occur. In paratenonitis, ... Soft tissue, Skeletal system, Tendons, All stub articles, Musculoskeletal disease stubs). ...
Sjorgen's syndrome not associated with other health problems or connective tissue diseases) is hyper-methylated at its CpG ... diseases and can serve as clinical markers of disease severity and/or as therapeutic targets for controlling the diseases. ... On the other hand, the CpG cluster(s) controlling the CMTM5 gene in the blood of individuals with the autoimmune disease of ... Studies have reported that: 1) the levels of CMTM5-v1 in the malignant tissues of patients with prostate cancer are lower than ...
... are infections of skin and associated soft tissues (such as loose connective tissue and mucous membranes).[citation needed] ... "Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections: 2014 Update by the Infectious Diseases ... Skin and skin structure infections (SSSIs), also referred to as skin and soft tissue infections (SSTIs), or acute bacterial ... List of cutaneous conditions Linezolid Tedizolid SSTI is the preferred description of the Infectious Diseases Society of ...
As tendons develop they lay down collagen, which is the main structural protein of connective tissue. As tendons pass near bony ... Diseases and surgery of the globe and orbit". In Gilger, BC (ed.). Equine Ophthalmology (3rd ed.). John Wiley & Sons. p. 151. ... Tendons are cords of connective tissue attaching muscle to bone, cartilage or other tendons. They are a major contributor to ... In equine ovaries, unlike in humans, the vascular tissue is cortical to follicular tissue, so ovulation can only occur at an ...
Occasionally, this inflammation can cause scar tissue to form on Glisson's capsule, a thin layer of connective tissue ... Bacterial diseases, Gynaecologic disorders, Syndromes in females, Rare syndromes, Rare infectious diseases, Gonorrhea). ... Pelvic Inflammatory Disease at eMedicine Pregerson, Brady (2010). Quick Essentials: Emergency Medicine (4th ed.). ISBN 978-0- ... Fitz-Hugh-Curtis syndrome is a rare complication of pelvic inflammatory disease (PID) involving liver capsule inflammation ...
Some systemic diseases, such as connective tissue disease, can cause MPS. Poor posture and emotional disturbance might also ... Myofascial pain is pain in muscles or fascia (a type of connective tissue that surrounds muscles). It can occur in distinct, ... connective tissue) constrictions. It can appear in any body part. Symptoms of a myofascial trigger points include: focal point ... Soft tissue disorders, Ailments of unknown cause, Disorders of fascia, Pain, Chronic pain syndromes, Rheumatology, Urologic ...
... syndrome Congestive heart failure Conjunctivitis ligneous Conjunctivitis with pseudomembrane Conjunctivitis Connective tissue ... Marie-Tooth disease type 1A Charcot-Marie-Tooth disease type 1B Charcot-Marie-Tooth disease type 1C Charcot-Marie-Tooth disease ... Marie-Tooth disease type 2C Charcot-Marie-Tooth disease type 2D Charcot-Marie-Tooth disease type 4A Charcot-Marie-Tooth disease ... Tooth disease Charcot-Marie-Tooth disease Charcot-Marie-Tooth disease deafness dominant type Charcot-Marie-Tooth disease ...
... mixed connective tissue disease, poststreptococcal glomerulonephritis, rheumatoid arthritis, and systemic sclerosis. Less ... Respiratory disease stubs, Disease stubs, Genitourinary system stubs). ... Pulmonary-renal syndromes are most commonly caused by an underlying autoimmune disease. PRS is most commonly due to ANCA- ... associated vasculitides (e.g., granulomatosis with polyangiitis) or due to anti-basement membrane diseases (e.g., Goodpasture's ...
... is an association between familial thoracic aortic aneurysm and Marfan syndrome as well as other hereditary connective tissue ... Diseases of the aorta, Genetic disorders by system). ...
... spindle-shaped or star-shaped fibroblasts and ectatic blood vessels in a dense collagen fiber connective tissue background. In ... and uncommonly in individuals that do not have this genetic disease. One individual with another rare genetic disease that has ... Sobanko JF, Dagum AB, Davis IC, Kriegel DA (June 2007). "Soft tissue tumors of the hand. 1. Benign". Dermatologic Surgery. 33 ( ... The treatment of KTs has varied depending on their size, numbers, locations, symptoms, damage to tissues, and disfiguring ...
As well as glands, the seminal vesicles contain smooth muscle and connective tissue. This fibrous and muscular tissue surrounds ... These diseases are investigated, diagnosed and treated according to the underlying disease. Benign tumours of the seminal ... Diseases of the Seminal vesicles as opposed to that of prostate gland are extremely rare and are infrequently reported in the ... Symptoms due to diseases of the seminal vesicles may be vague and not able to be specifically attributable to the vesicles ...
The segments are separated from each other by layers of connective tissue that forms them into discrete anatomical and ... Tuberculosis of the lung is a common disease in certain parts of the world. A complete course of treatment must be taken under ... Bronchial Asthma is a common disease of the respiratory system. It occurs due to bronchospasm of smooth muscles in the wall of ... Diseases of the Chest. 11 (6): 511-564. doi:10.1378/chest.11.6.511. ISSN 0096-0217. Ugalde, Paula; Camargo, Jose de Jesus; ...
Skeletal muscle includes skeletal muscle fibers, blood vessels, nerve fibers, and connective tissue. Skeletal muscle is wrapped ... Coronary artery disease (narrowed coronary arteries) Arrhythmia (irregular heartbeat) Cardiomyopathy (disease of the heart ... Striated muscle tissue is a muscle tissue that features repeating functional units called sarcomeres. The presence of ... Unlike skeletal and cardiac muscle tissue, smooth muscle tissue is not striated since there are no sarcomeres present. Skeletal ...
... muscle or connective tissue are intact, a skin graft can be used. A skin graft needs healthy, vascularised tissue beneath it to ... In Medieval times, people were convinced that trepanation was a remedy for various diseases.[citation needed] Main reasons for ... The large blood vessels and nerves of the scalp don't pierce this layer.Loose connective tissue between the periosteum and the ... If this is not possible without tension, the surrounding loose connective tissue can be undermined to attain more mobility. ...
... before any genetic or morphological criteria were put in place for bone marrow or connective tissues. Osteoprogenitor cells can ... The disease has symptoms similar to those resulting from Trsp gene knockout. Loss of the regulator, Pten, of the ... These cellular units will then develop into skeletal and other tissues, such as cartilage, tendon, ligament and muscle tissue.[ ... The results of this research was used as a model for Kashin-Beck disease. Kashin-Beck is a result of combinatorial ...
"The subepithelial connective tissue pedicle graft combined with the coronally advanced flap for restoring missing papilla: A ... 5. Periodontal disease and loss of attachment, resulting in recession. 6. Tooth morphology and abnormal crown and restoration ... 3. Gingiva biotype; thick and thin tissues often respond differently to inflammation and trauma, thin gingiva is more liable to ...
Rheumatic disease is an umbrella term for conditions causing chronic pain affecting the joints and/or connective tissue. Common ... and Aaseth has studied and discussed the role of iron chelation in the disease-modifying treatment of Parkinson's disease. ... including Parkinson's disease, Alzheimer's disease, multiple sclerosis, and autism spectrum disorder (ASD). Environmental ... Aaseth has acted as a medical expert for the Supreme Court of Norway in questions regarding occupational disease related to ...
Boyd van Hoeij wrote in Variety, "Though some individual moments work, Delpy's screenplay lacks psychological connective tissue ... After Nádasdy's return from the Ottoman-Hungarian Wars, he succumbs to a disease he contracted abroad and dies. Erzsébet, now ...
Verrucous xanthoma, or histiocytosis Y: a papilloma of the oral mucosa and skin whereby the connective tissue under the ... James WD, Berger TG, Elston DM, Odom RB (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN ... is a deposition of yellowish cholesterol-rich material that can appear anywhere in the body in various disease states. They are ... and within the same disease spectrum as eruptive xanthomata. Other types of xanthoma identified in the Medical Dictionary ...
It is composed of dense irregular connective tissue and areolar connective tissue such as a collagen with elastin arranged in a ... Possible diseases and injuries to the human integumentary system include: Rash Yeast Athlete's foot Infection Sunburn Skin ... loose connective tissue. The reticular layer is the deep layer of the dermis and consists of the dense irregular connective ... and contains connective tissues, vessels, glands, follicles, hair roots, sensory nerve endings, and muscular tissue. Between ...
... bone and connective tissues. Overwhelming disorganization of cellular processes involved in the formation of cartilage and bone ... Rare diseases, Genetic disorders with OMIM but no gene). ... specialized cells that make up fibrous connective tissue, which ... Tissue Engineering. 10 (1-2): 129-37. doi:10.1089/107632704322791772. ISSN 1076-3279. PMID 15009938. (CS1: long volume value, ... causing abnormal fibrous development of cartilage and related tissues. It is a lethal rhizomelic (malformations which result in ...
Connective tissue diseases). ... This disease was first referred to as Atrophoderma of Moulin ... A new disease picture, following the Blaschko lines]". Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte ...
... but also the all components of the loose connective tissue including removing fibrosis in the interstitial space. Ultrasound- ... 2010). Microcannular tumescent liposuction in advanced lipedema and Dercum's disease. Giornale italiano di dermatologia e ... Risk is increased when treated areas cover a greater percentage of the body, incisions are numerous, a large amount of tissue ... Seroma is a pooling of serum, the straw-colored liquid from blood, in areas where tissue has been removed. Paresthesias ( ...
... which breaks down the connective tissue fiber elastin. Besides limiting elastase activity to limit tissue degradation, A1PI ... These antibodies are associated with a more severe disease course, can be observed years before disease onset, and may predict ... Besides liver cells, A1PI is produced in bone marrow, by lymphocytic and monocytic cells in lymphoid tissue, and by the Paneth ... This suggests a role for α1PI not only in locomotion of lymphocytes through tissue, but as a consequence of infection, a ...
It is somewhat similar to other genetic connective tissue disorders such as Ehlers-Danlos syndromes. There is a strong ... "Hypermobile Ehlers-Danlos syndrome , Genetic and Rare Diseases Information Center (GARD) - an NCATS Program". rarediseases.info ... is a heritable connective tissue disorder that affects joints and ligaments. Different forms and sub-types have been ... are diagnosed when individuals have symptomatic joint hypermobility but do not meet the criteria for other connective tissue ...
Ott C, Iwanciw D, Graness A, Giehl K, Goppelt-Struebe M (November 2003). "Modulation of the expression of connective tissue ... tau proteins have also been shown to stabilize microtubules in axons and have been implicated in Alzheimer's disease. The ... this relation exists for connective tissue growth factor. Biology portal Microtentacle Orchestrated objective reduction - a ... The originally identified MAPs from brain tissue can be classified into two groups based on their molecular weight. This first ...
Vertebrate brains are surrounded by a system of connective tissue membranes called meninges that separate the skull from the ... A prion disease called kuru has been traced to this. Brain-computer interface Central nervous system disease List of ... The brains of vertebrates are made of very soft tissue. Living brain tissue is pinkish on the outside and mostly white on the ... Brain tissue in its natural state is too soft to work with, but it can be hardened by immersion in alcohol or other fixatives, ...
... in which unstable fibrous connective tissue is formed instead of bone, and going too slowly can allow premature union to occur ... Drugs and Diseases. Rossini G, Vinci B, Rizzo R, Pinho TM, Deregibus A (November 2016). "Mandibular distraction osteogenesis: a ... correspondence between skeletal and soft tissue was found for sagittal positioning; the dental-to-soft tissue agreement was ... In 2016, a systematic review of papers describing bone and soft tissue outcomes of DO procedures on the lower jawbone was ...
... that pain in her wrist originally thought to be from a sports injury was actually from a connective tissue and bone disease. ...
disease and has_disease_location some (connective tissue or part of some connective tissue) ... connective tissue disorder this grouping excludes some diseases affecting tissues classically considered to be connective ... connective tissue disease. Go to external page http://www.ebi.ac.uk/efo/EFO_1001986 Copy ... A disease involving the connective tissue. [ https://orcid.org/0000-0002-6601-2165 ] ...
Mixed connective-tissue disease (MCTD) was first recognized by Sharp and colleagues (1972) in a group of patients with ... encoded search term (Mixed Connective-Tissue Disease (MCTD)) and Mixed Connective-Tissue Disease (MCTD) What to Read Next on ... The HLA profiles of mixed connective tissue disease differ distinctly from the profiles of clinically related connective tissue ... Classification and diagnostic criteria for mixed connective tissue disease. Kasukawa R, Sharp GC, eds. Mixed Connective Tissue ...
... a case of severe hepatic toxicity for whom TMP-SMZ was prescribed as part of treatment for mixed connective tissue disease ( ... Trimethoprim-Sulfamethoxazole-Induced Hepatitis in Mixed Connective Tissue Disease () Takeshi Sugimoto, Yumiko Nobuhara, Seiji ... "Trimethoprim-Sulfamethoxazole-Induced Hepatitis in Mixed Connective Tissue Disease," International Journal of Clinical Medicine ... a case of severe hepatic toxicity for whom TMP-SMZ was prescribed as part of treatment for mixed connective tissue disease ( ...
Sharp and colleagues first proposed mixed connective tissue disease (MCTD) as a separate autoimmune disorder. The initial ... encoded search term (Pediatric Mixed Connective Tissue Disease) and Pediatric Mixed Connective Tissue Disease What to Read Next ... Classification and diagnostic criteria for mixed connective tissue disease. Kasukawa R, Sharp GC, eds. Mixed Connective Tissue ... Drugs & Diseases , Pediatrics: General Medicine Pediatric Mixed Connective Tissue Disease Treatment & Management. Updated: Jul ...
Glossary: Mixed connective tissue disease. Mixed connective tissue disease (MCTD) is a autoimmune disorder that causes ... overlapping features of three connective tissue disorders: lupus, scleroderma, and polymyositis. MCTD may also have features of ...
Hypertensive disorders of pregnancy predict chronic kidney disease and end-stage renal disease Ayub Akbari ... Beyond genetics: focusing on maternal environment for congenital heart disease prevention Vidu Garg, Madhumita Basu ...
Copyright © 2022 BMJ Publishing Group Ltd & Royal College of Paediatrics and Child Health. All rights reserved.. ...
Connective Tissue Diseases. Vascular Diseases. Cardiovascular Diseases. Hypertension, Pulmonary. Lung Diseases. Respiratory ... Condition or disease Intervention/treatment Phase Connective Tissue Disease-Associated Pulmonary Arterial Hypertension Drug: ... Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial Hypertension - CATALYST. The safety ... Connective Tissue Disease-Associated Pulmonary Arterial Hypertension. Bardoxolone methyl. PAH. RTA 402. 6-minute walk distance ...
I had some early symptoms of Marfan Syndrome, a disease that affects connective tissues and can be fatal if there is leakage to ... a connective tissue disorder. The diagnosis was based on physical observations of Lincoln: the fact that he was much taller ... Peter Roe and the tissues are strong, the aortic rout is clear and my heart is in good shape - as long as my Baltimore Ravens ... Actor With Marfans Connective Tissue Disease Actor With Marfans Connective Tissue Disease ...
Cyclophosphamide for Connective Tissue Disease-Associated Interstitial Lung Disease. * Summit on Connective Tissue Disease- ... Cyclophosphamide for Connective Tissue Disease-Associated Interstitial Lung Disease. *Summit on Connective Tissue Disease- ... Tackle Tricky Lung Complications in Connective Tissue Disease. Tackle Tricky Lung Complications in Connective Tissue Disease. ... A panel of experts on connective tissue-associated ILD spoke at a session titled, "Connective Tissue Disease-Associated ...
Connective tissue disease service > *Visiting the CTD service. In this section. *Connective tissue disease service *CTD clincs ...
Connective tissue disease Inflammatory rheumatic disorders Osteoporosis Pain management Rheumatology Rheumatoid arthritis Soft ... lupus and other auto immune diseases, systemic vasculitis, fibromyalgia. ... tissue rheumatism Special clinical interests: Early inflammatory arthritis, polymyalgia rheumatica, temporal arteritis, gout, ...
In the Rituximab versus Cyclophosphamide for the Treatment of Connective Tissue Disease Associated Interstitial Lung Disease ( ... Rituximab versus Cyclophosphamide for the Treatment of Connective Tissue Disease Associated Interstitial Lung Disease (RECITAL ... Rituximab, Cyclophosphamide Beneficial for Treating Connective Tissue Disease-Related ILD. Emily Pond ... Close more info about Rituximab, Cyclophosphamide Beneficial for Treating Connective Tissue Disease-Related ILD ...
Like a Wasting Disease, Neoliberals, Libertarians & the Right are Eating Away Societys "Connective Tissue" - Part 1. Posted on ... Like a Wasting Disease, Neoliberals, Libertarians & the Right are Eating Away Societys "Connective Tissue" - Part 2 → ... Like a Wasting Disease, Neoliberals, Libertarians & the Right are Eating Away Societys "Connective Tissue" - Part 2 → ... 25 responses to "Like a Wasting Disease, Neoliberals, Libertarians & the Right are Eating Away Societys "Connective Tissue" - ...
It is the worlds largest CME collection for lung diseases and treatment offering high quality e-learning and teaching ... Connective tissue disease and interstitial lung disease. Year: 2013. Pivotal clinical dilemmas in collagen vascular diseases ... Clinico-radiological profile of connective tissue diseases related interstitial lung diseases. M. Agarwal (Jodhpur, India), M. ... Interstitial lung disease in patients with connective tissue diseases - a report of 3 cases. Source: Eur Respir J 2004; 24: ...
... and undifferentiated connective tissue disease (UCTD), n = 85] by indirect immunofluorescence (IIF), protein-IP, and IP-WB to ... of sera from patients with connective tissue disease had a cytoplasmic reticular pattern at IIF, and in 77% (44/57, including ... cholestasis in rheumatic patients.Patients and methodsWe studied sera from 285 patients affected by connective tissue disease [ ... a strict follow-up of these latter patients is warranted for an early diagnosis of the disease. ...
Primary (ie no other connective tissue disease) o Secondary: associated with other connective tissue diseases: Rheumatoid (50% ... Progressive Systemic Sclerosis (PSS) - Connective Tissue Diseases. Polymyositis and Dermatomyositis - Connective Tissue ... Connective tissue disease o Lymphocytes and plasma cells infiltrate secretory glands (also skin, lungs and liver) causing ... Systemic Lupus Erythematosus - Connective Tissue Diseases. Sjogren s Syndrome - Connective Tissue Diseases ...
... linked genetic background between mixed connective tissue disease and systemic lupus erythematosus. Tissue antigens, 41(1), 20- ... linked genetic background between mixed connective tissue disease and systemic lupus erythematosus, Tissue antigens, vol. 41, ... linked genetic background between mixed connective tissue disease and systemic lupus erythematosus. Tissue antigens. 1993 Jan; ... linked genetic background between mixed connective tissue disease and systemic lupus erythematosus. In: Tissue antigens. 1993 ...
Rare Autoimmune/Complex Connective Tissue Diseases ] [ Rare Hereditary Connective Tissue Diseases ] [ Standardization Of Care ... Rare Autoimmune/Complex Connective Tissue Diseases ] [ Rare Hereditary Connective Tissue Diseases ] [ Standardization Of Care ... Rare Autoimmune/Complex Connective Tissue Diseases ] [ Rare Hereditary Connective Tissue Diseases ] [ Standardization Of Care ... Keywords : [ Complex Connective Tissue Diseases ] [ Education ] [ Hta ] [ Knowledge Improvement ] [ Patient Empowerment ] [ ...
Fellows will work under the mentorship of Gideon P. Smith MD PhD, Director of the Connective Tissue Diseases clinic, a combined ... Fellows will also have the opportunity to participate in patient management in the MGH Connective Tissue Diseases Clinic, ... offers a 1-year Fellowship in Connective Tissue Diseases. The fellowship is 1 year and is directed at the career development of ... In addition to mentored clinical time in the MGH Connective Tissue Clinic, fellows may also elect to gain exposure to ...
Mixed connective tissue disease. Mixed connective tissue disease is a clinical diagnosis comprising of systemic sclerosis, ... Connective tissue diseases comprised of systemic sclerosis, lupus erythematosus, mixed connective tissue disease, ... Connective tissue diseases comprised of systemic sclerosis, lupus erythematosus, mixed connective tissue disease, ... making early diagnosis of connective tissue diseases and thus preventing morbidities and sequelae of connective tissue diseases ...
There are over 200 disorders that affect connective tissues. Examples include cellulitis, scars, and osteogenesis imperfecta. ... Connective Tissue Diseases (National Institutes of Health) * ClinicalTrials.gov: Mixed Connective Tissue Disease (National ... Article: Monitoring small airway dysfunction in connective tissue disease-related interstitial lung disease:... ... Cartilage and fat are types of connective tissue.. Over 200 disorders that impact connective tissue. There are different types: ...
A Topographical Approach to Early Cancer and Connective Tissue Disease Detection. December 5, 2021 ...
Connective tissue diseases versus overlap syndrome. Journal of the Association of Physicians of India. 1984 Jul; 32(7): 555-9. ...
See Conditions by Category , Skin and Connective Tissue Diseases. Please enable JavaScript to see the table of Conditions ...
Connective tissue diseases. Scleroderma-associated digital ischemia manifests as increased nail plate curvature, loss of distal ... Mucoid degeneration of connective tissue with metaplasia and proliferation of fibroblasts, leading to excess hyaluronic acid, ... Radiological Imaging of Nail Disorders (PART II) - Radiological Features of Nail Disease : Indian Dermatology Online Journal. ... A spontaneous regression may be present in few cases.[3132] Radiographs show a crescent-shaped soft tissue mass, with a ...
Mixed Connective Tissue Disease. I represent an industrial salesman from Oregon whose application for Social Security ... The claimant was diagnosed with mixed connective tissue disease ("MCTD"). According to the Mayo Clinic, MCTD is an uncommon ... autoimmune disorder that causes overlapping features of primarily three connective tissue diseases - lupus, scleroderma and ...
Products and information presented herein are not intended to diagnose, treat, cure, or prevent disease. If you have any ... Table of Contents , Uses , connective tissue diseases. Herbs and Supplements for connective tissue diseases. ...
Other Connective Tissue Diseases answers are found in the Harrisons Manual of Medicine powered by Unbound Medicine. Available ... Tissue_Diseases. Chapter 164: Other Connective Tissue Diseases [Internet]. In: Kasper DLD, Fauci ASA, Hauser SLS, Longo DLD, ... Diseases. Chapter 164: Other Connective Tissue Diseases. In: Kasper DLD, Fauci ASA, Hauser SLS, et al, eds. Harrisons Manual ... Diseases. Accessed December 8, 2022.. Chapter 164: Other Connective Tissue Diseases. (2017). In Kasper, D. L., Fauci, A. S., ...
  • Mixed connective tissue disease (MCTD) is a autoimmune disorder that causes overlapping features of three connective tissue disorders: lupus, scleroderma, and polymyositis. (lupusresearch.org)
  • Over 200 disorders that impact connective tissue. (medlineplus.gov)
  • There are several disorders that can directly affect the various connective tissues of the body. (factdr.com)
  • This a group of disorders of the connective tissue that arise as a result of defective mutations in the genes. (factdr.com)
  • Collagen Vascular Lung Disease Collagen vascular or connective tissue disorders are a group of autoimmune diseases in which antibodies attack the body's own organs and systems. (stevefrithphotography.com)
  • Connective tissues diseases (CTDs) are a heterogeneous group of disorders that share certain clinical characteristics and disturbed immunoregulation. (archivesofmedicalscience.com)
  • Find out what you know about diseases, disorders, and more. (britannica.com)
  • Microbial imbalance or dysbiosis in the gut microbiome is associated with illness and disorders, including interstitial lung diseases (ILDs) ( 7 - 10 ). (frontiersin.org)
  • ILDs, otherwise called diffuse parenchymal lung diseases, are a group of disorders characterized by chronic inflammation that result in fibrosis (scarring) of the lung ( 13 ). (frontiersin.org)
  • There are between 100-150 rheumatic disease varieties and the term rheumatism is a layperson term describing joint pain and stiffness and not specifically rheumatic disorders. (news-medical.net)
  • Aquatic therapy can help children with a variety of diagnoses, from connective tissue diseases to neurological disorders. (cincinnatichildrens.org)
  • The following aspects of specific occupational diseases were covered in the plans for this fiscal year: behavioral and neurotoxic effects, cancer, reproductive effects, respiratory disease, musculoskeletal and connective tissue disorders, cutaneous disease, sensory disorders, cardiovascular disease, and infective and parasitic disorders. (cdc.gov)
  • Although not fully characterized, the known risk factors for P. jirovecii infection include impaired immunity because of HIV infection, hematologic malignancies, and connective tissue disorders ( 6 ). (cdc.gov)
  • Diffuse proliferative glomerulonephritis (DPGN) is a term used to describe a distinct histologic form of glomerulonephritis common to various types of systemic inflammatory diseases, including autoimmune disorders (eg, systemic lupus erythematosus [SLE]), vasculitis syndromes (eg, granulomatosis with polyangiitis), and infectious processes. (medscape.com)
  • Rheumatologists deal mainly with clinical problems involving joints, soft tissues, autoimmune diseases, vacuities, and heritable connective tissue disorders. (drabhrajitray.com)
  • Many of these diseases are now known to be disorders of the immune system. (drabhrajitray.com)
  • These conditions are very rare and sometimes are attributed to maternal autoimmune disorders (ie, maternal connective tissue disease). (aacnjournals.org)
  • Conclusions: However, given the multifactorial nature of occupational diseases, it is likely that overweight and obesity may act as a predisposing factor in these diseases, interacting and enhancing the effects of other important risk factors for the occurrence of work-related musculoskeletal disorders. (bvsalud.org)
  • 1 Other congenital abnormalities of the aortic valve, degenerative calcific aortic stenosis, aortic insufficiency secondary to connective tissue disorders, and rheumatic aortic valve disease, are also predisposing lesions for infection. (mhmedical.com)
  • Such disorders of the heart, kidneys, bone, and metabolism are known to be associated with diseases characterized by persistent inflammation in patients without HIV. (amfar.org)
  • Overlapping criteria for diagnosis of mixed connective tissue disease (MCTD) have been published by Sharp, Alarcón-Segovia, Kasukawa, and Kahn. (medscape.com)
  • 2019 Diagnostic criteria for mixed connective tissue disease (MCTD): From the Japan research committee of the ministry of health, labor, and welfare for systemic autoimmune diseases. (medscape.com)
  • The most important tools in treatment of mixed connective tissue disease (MCTD) include tailoring the medical regimen, promptly attending to disease flare, and performing careful and frequent clinical and laboratory evaluations to test for new disease manifestations. (medscape.com)
  • We present a case of severe hepatic toxicity for whom TMP-SMZ was prescribed as part of treatment for mixed connective tissue disease (MCTD). (scirp.org)
  • Treatment with cyclophosphamide and rituximab is beneficial for interstitial lung disease (ILD) associated with idiopathic inflammatory myositis (IIM) and mixed connective tissue disease (MCTD) compared with systemic sclerosis (SSc), according to research findings presented at the American College of Rheumatology (ACR) Convergence 2022, held from November 10 to 14, in Philadelphia, Pennsylvania. (infectiousdiseaseadvisor.com)
  • We have typed 64 Japanese patients with mixed connective tissue disease (MCTD) and 53 Japanese patients with systemic lupus erythematosus (SLE) for HLA‐DRB1, DRB3, DRB4, DRB5, DQA1, DQB1, and DPB1 genes by the HLA‐DNA typing method using the PCR‐SSOP technique. (elsevier.com)
  • According to the Mayo Clinic, MCTD is an uncommon autoimmune disorder that causes overlapping features of primarily three connective tissue diseases - lupus, scleroderma and polymyositis, and it also may have features of rheumatoid arthritis. (iwantmydisability.com)
  • Mixed connective tissue disease (MCTD) is a type of connective tissue regards to clinical and imaging features, it can have significant overlap with other connective tissue diseases such as systemic lupus erythematosus and scleroderma is therefore classified as a type of overlap syndrome and at times it even comes under debate as to whether MCTD should exist as a distinct. (stevefrithphotography.com)
  • We described a 69-year-old woman with neurological manifestations due to mixed connective tissue disease (MCTD). (who.int)
  • The aim of the ERN-RECONNET's annual work plan for 2017 is to establish a community to enhance transnational cooperation between different groups (healthcare providers, patients, caregivers and families, stakeholders, etc.) to develop a comprehensive and harmonized approach to rare and complex autoimmune and hereditary connective and musculoskeletal diseases (rCTDs). (europa.eu)
  • 2017. https://harrisons.unboundmedicine.com/harrisons/view/Harrisons-Manual-of-Medicine/623704/all/Chapter_164:_Other_Connective_Tissue_Diseases. (unboundmedicine.com)
  • This meeting was aimed to create collaboration among the Italian HCPs involved in the European Reference Networks (ERN), that as highlighted by Andrzej Jan Rys (Director HelathSystems, Medical Products and Innovation, DG Sante') are virtual networks of specialists officially born in March 2017, dedicated to the diagnosis and treatment of diseases complex or rare. (brains4brain.eu)
  • Aug 16, 2017·Connective Tissue. (geertroovers.nl)
  • d in scleroderma-associated pulmonary hypertension, pulmonary complications of connective tissue disease , idiopathic pulmonary fibrosis and pulmonary hypertension. (hopkinsmedicine.org)
  • Scleroderma is an autoimmune connective tissue and rheumatic disease that causes inflammation in the skin and other areas of the body. (nih.gov)
  • Pulmonary hypertension can occur idiopathically as a primary disorder of the pulmonary circulation or more commonly, it can exist as a haemodynamic manifestation of a wide variety of pulmonary and cardiovascular diseases, including acute lung injury, chronic obstructive lung disease, congenital heart disease, mitral stenosis, chronic left-sided congestive heart failure and connective tissue diseases such as scleroderma. (utmb.edu)
  • The Rheumatology Department at Kernodle Clinic provides evaluation and management of patients with various types of arthritis including rheumatoid arthritis, osteoarthritis, and gout as well as patients with systemic inflammatory diseases such as scleroderma, lupus, polymyalgia rheumatic, and temporal arthritis. (kernodle.com)
  • They quickly diagnosed that I had a mixed connective tissue disease with overlapping lupus and scleroderma. (medlineplus.gov)
  • They also found I had pulmonary arterial hypertension and interstitial lung disease which resulted from the scleroderma. (medlineplus.gov)
  • Amigues JM, Cantagrel A, Abbal M, Mazieres B. Comparative study of 4 diagnosis criteria sets for mixed connective tissue disease in patients with anti-RNP antibodies. (medscape.com)
  • Ortega-Hernandez OD, Shoenfeld Y. Mixed connective tissue disease: An overview of clinical manifestations, diagnosis and treatment. (medscape.com)
  • In view of the strong predictive value of AMA for PBC, a strict follow-up of these latter patients is warranted for an early diagnosis of the disease. (ox.ac.uk)
  • However, in some diseases like retronychia and some nail tumors, radiological findings help clinch the diagnosis. (lww.com)
  • Radiological diagnosis of nail disease is a fast evolving field. (lww.com)
  • In this review, we summarize studies describing the role of the microbiome in interstitial lung disease and discuss the implications of these findings on the diagnosis and treatment of these diseases. (frontiersin.org)
  • However, within specific populations such as at risk groups (e.g., patients with connective tissue disease), we urge increased awareness and adherence to consensus guidelines in terms of screening and diagnosis. (renalandurologynews.com)
  • The differential diagnosis of an acute disease of the spinal cord includes many conditions [6,7]. (who.int)
  • The goal of this review article is to provide an overview of the clinical and radiologic diagnosis of UIP/idiopathic pulmonary fibrosis (IPF) and mimickers of the disease with the main goal being ability to answer the question, "Is it IPF or not? (medscape.com)
  • Early disease diagnosis leads to improved outcomes for patients. (medscape.com)
  • and non-traditional players, like technology companies, ERNs can create a new coordinated way to manage patients affected by rare diseases and optimize access to diagnosis and therapy. (brains4brain.eu)
  • We identified all patients for whom an International Classification of Diseases, 10th Revision (ICD-10), code B59, which corresponds with P. jirovecii infection, was recorded in any of the first 10 diagnosis fields from January 2000 through December 2010. (cdc.gov)
  • Connective tissue diseases: Diagnosis of cognitive impairment in adult and pediatric SLE. (bvsalud.org)
  • The diagnosis of DPGN is often suspected in a patient presenting with a systemic inflammatory disease who manifests hematuria, proteinuria, and active urinary sediment or azotemia (ie, rise in serum urea nitrogen, creatinine). (medscape.com)
  • Histologic findings from kidney biopsy tissue are used to confirm the diagnosis. (medscape.com)
  • Rheumatology is a sub-specialty in internal medicine and pediatrics, devoted to diagnosis and therapy of rheumatic diseases. (drabhrajitray.com)
  • av S Acharya · 2018 · Citerat av 1 - that would facilitate the diagnosis and treatment of patients with BMS in the controls from skin diseases such as rosacea, eczema, dry skin and psoriasis. (web.app)
  • She is familiar with the diagnosis and treatment of a variety of diseases in both outpatient and inpatient settings. (ucfhealth.com)
  • Following clinical usage of the term 'connective tissue disorder' this grouping excludes some diseases affecting tissues classically considered to be connective tissue, such as bone. (ebi.ac.uk)
  • In the early 1960s, a physician published a paper which stated that President Abraham Lincoln had Marfan syndrome, a connective tissue disorder. (dinet.org)
  • Marfan syndrome is a genetic disorder that affects the body's ability to make healthy connective tissue, which supports the bones, muscles, organs, and tissues in your body. (nih.gov)
  • Infection, bone fracture, connective tissue disorder, excessive stress, and certain disease conditions such as rheumatoid arthritis and osteoarthritis can cause ankle arthritis. (davidbeckmd.com)
  • Infection, bone fracture, connective tissue disorder, excessive stress, and certain disease conditions such as rheumatoid arthritis, and osteoarthritis are causes of ankle arthritis. (atlantaorthopaedicinstitute.com)
  • The cause of BAVD is unknown, but it is thought to be caused by a connective tissue disorder, similar to the condition that causes Marfan syndrome. (houstonmethodist.org)
  • The disease commonly affects young adults, particularly men aged between 20 and 40 years.3 Infection is thought to be acquired by traumatic inoculation of fungi or bacteria into the subcutaneous tissue following minor trauma or a penetrating injury, commonly thorn pricks. (who.int)
  • The role of connective tissue, as the name suggests, is to bind, support and connect other tissues and organs together. (factdr.com)
  • These three components come together to form the glue that provides the extracellular matrix for other tissues and organs. (factdr.com)
  • Since connective tissues form the structural framework within our bodies, diseases affecting them will also have an impact on organs and other tissues associated with them. (factdr.com)
  • amyloidosis , disease characterized by the deposition of an abnormal protein called amyloid in the connective tissues and organs of the body that inhibits normal functioning. (britannica.com)
  • Amyloidosis may be systemic (affecting tissues and organs throughout the body), or it may be localized in tumourlike masses within certain organs. (britannica.com)
  • The organs most commonly affected by the disease include the kidneys , heart , liver , spleen , lungs , and skin . (britannica.com)
  • In this case, the white blood cells may begin to attack cells, tissues, and organs. (dragoosoilblends.com)
  • 3. Reticular fibers -provide a network to support blood vessels and support soft tissue of organs.Tissues Class 9 Notes - Chapter 6 Important Points To KnowCBSE Class 9 Science Notes on Tissues. (geertroovers.nl)
  • Multi-morbid fibrotic disease defines groups (clusters) of conditions that occur together and are characterised by scarring in various organs. (ukri.org)
  • We will determine whether the biological pathways which are responsible for lung, liver or bone marrow fibrosis may also lead to scarring in other organs and whether they link expanded clusters of scarring involving the lung, liver, pancreas, kidney, bone marrow, brain, heart, gastrointestinal tract, or whether there are other genes that promote different clusters of scarring disease. (ukri.org)
  • We will then investigate whether medicines that are known to protect against certain fibrotic diseases within these clusters (for example metformin for diabetes and simvastatin for heart disease and stroke) might have beneficial affects across the full spectrum of fibrotic disease by targeting disease pathways that are shared across the different organs. (ukri.org)
  • We will use these data to inform: a) The development of the DEMISTIFI cohort of patients at risk of MMF disease, who will be deeply phenotyped for development of pre-symptomatic multi organ fibrosis using genetics and imaging characteristics of multiple organs linked to physiology and pathobiology. (ukri.org)
  • Endogenous lipoid pneumonia associated with undifferentiated connective tissue disease (UCTD). (medscimonit.com)
  • T. Sugimoto, Y. Nobuhara, S. Kawano and A. Morinobu, "Trimethoprim-Sulfamethoxazole-Induced Hepatitis in Mixed Connective Tissue Disease," International Journal of Clinical Medicine , Vol. 2 No. 5, 2011, pp. 629-632. (scirp.org)
  • Antigen Reactivity and Clinical Significance of Autoantibodies Directed Against the Pyruvate Dehydrogenase Antigen Complex in Patients With Connective Tissue Disease. (ox.ac.uk)
  • In systemic diseases with microvasculature damage as a prominent feature, abnormalities of nailfold capillaries can be appreciated before the onset of clinical disease. (cdriadvlkn.org)
  • In addition to mentored clinical time in the MGH Connective Tissue Clinic, fellows may also elect to gain exposure to rheumatology clinics for joint exam and ultrasound, the PFT evaluation or radiology for CT and MRI for further understanding of these areas. (medresidency.com)
  • However, given the long latency, 20 or more years, of most silica-related health conditions and the fact that fracking did not become widely used until the 2000s, it may be years before health care providers see clinical-related disease in their practices. (cdc.gov)
  • Clinical onset of the Crohn's disease after eradication therapy of Helicobacter pylori infection. (medscimonit.com)
  • One of the most serious connective tissue-associated ILDs is usual interstitial pneumonia (UIP), an idiopathic condition marked by a honeycombing pattern seen on radiographs and fibrosis, Dr. Fischer said. (the-rheumatologist.org)
  • Idiopathic pulmonary arterial hypertension (formerly referred to as primary pulmonary hypertension) is an uncommon yet progressively fatal disease defined by the presence of mean pulmonary artery pressure greater than 25mmHg at rest or greater than 30mmHg with exercise as tested by right heart catheterization in the absence of other etiologies for pulmonary hypertension. (stevefrithphotography.com)
  • Usual interstitial pneumonitis (UIP)/idiopathic pulmonary fibrosis (IPF) is the most common of the idiopathic pulmonary fibrotic diseases and has the worst prognosis with a mean life expectancy of 3.8 years. (medscape.com)
  • Researchers used MEDLINE to perform a systematic literature review of studies between 2008 and 2018 comprising adult patients with connective tissue disease (CTD)-associated PAH and function class (FC) 2 or 3 idiopathic, heritable, repaired congenital heart defect, or drug- or toxin-induced PAH (the latter was considered one etiologic grouping, IPAH+) who were treated with oral prostacyclin pathway agents. (pulmonologyadvisor.com)
  • I have high blood pressure and PCOS, and Rheumatoid Arthritis increases the risk of heart disease as well. (arthriticchick.com)
  • and chronic inflammatory diseases like rheumatoid arthritis ( 16 ). (frontiersin.org)
  • As we get older, NFkB signaling increases and sets the body up for chronic inflammation, which causes greater vulnerability to diseases like Rheumatoid Arthritis, cancer, and Alzheimer's disease. (dragoosoilblends.com)
  • People with few health conditions such as rheumatoid arthritis, neurological, fibromyalgia, orthopedic problems, skin diseases, lung diseases are benefited with whole body cryotherapy . (onlinecancerguide.com)
  • Mixed connective tissue disease--an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). (medscape.com)
  • Other conditions that may be seen in rheumatic disease patients include lymphocytic interstitial pneumonia and, more rarely, severe acute interstitial pneumonia. (the-rheumatologist.org)
  • Diet restrictions are driven by medical therapy and disease manifestations. (medscape.com)
  • Pulmonary Manifestations of Connective Tissue Diseases toms, consistent PFTs and typical radiological find-ings. (stevefrithphotography.com)
  • The presence of classic findings for systemic diseases may suggest renal manifestations. (bmj.com)
  • Infective endocarditis is a disease in which a microorganism colonizes a focus in the heart, producing fever, heart murmur, splenomegaly, embolic manifestations, and bacteremia or fungemia. (mhmedical.com)
  • Neuropsychological assessment in mixed connective tissue disease: comparison with systemic lupus erythematosus. (medscape.com)
  • Systemic Lupus Erythematosus, Sjögren Syndrome, and Mixed Connective Tissue Disease in Children and Adolescents. (medscape.com)
  • 4] Thenceforth, nailfold capillaroscopy become an important diagnostic tool for diagnosing progressive connective tissue diseases such as systemic sclerosis, mixed connective tissue disease, lupus erythematosus, dermatomyositis, and polymyositis, and also in patients with Raynaud's phenomenon. (cdriadvlkn.org)
  • Some connective tissue diseases such as lupus erythematosus are associated with a specific type of hepatitis. (cdc.gov)
  • These exposure levels put workers, particularly sand mover operators and T-belt operators who had the highest levels, at risk of silicosis and the other silica-related conditions of lung cancer, end-stage renal disease, chronic obstructive pulmonary disease, tuberculosis, and connective tissue disease. (cdc.gov)
  • IgG4-related diseases (IgG4-RD) are a group of chronic relapsing remitting inflammatory conditions characterized by tissue infiltration with lymphocytes and IgG4-secreting plasma cells and subsequent tissue fibrosis. (ern-net.eu)
  • Advanced age is associated with chronic kidney disease, underlying renal vascular disease, and other comorbid medical conditions that predispose to AKI. (bmj.com)
  • Risks increase with increasing severity of chronic kidney disease. (bmj.com)
  • AKI incidence rates of 9% to 38% have been reported in patients with diabetes and chronic kidney disease undergoing contrast exposure. (bmj.com)
  • In other words, common things are common-with pulmonary hypertension related to left heart condition (WHO group II) or chronic lung disease/hypoxemia (WHO group III) being the two most common causes of pulmonary hypertension. (renalandurologynews.com)
  • Mycetoma is a chronic, progressively destructive inflammatory disease of the skin, subcutaneous and connective tissue, muscle and bone. (who.int)
  • Chemical imbalances and severe tissue damage may lead to chronic inflammation in one or more areas of the body. (dragoosoilblends.com)
  • As a result, chronic inflammation is believed to play a significant contributory role in in the cause and progression of arthritis, cancer, and Alzheimer's disease. (dragoosoilblends.com)
  • Cartilage and fat are types of connective tissue. (medlineplus.gov)
  • What are the different types of connective tissue diseases? (helpof.com)
  • Immune and inflammatory mechanisms could play a significant role in pulmonary arterial hypertension (PAH) genesis or progression, especially in patients with connective tissue diseases. (stevefrithphotography.com)
  • Does Helicobacter pylori infection interact with natural history of inflammatory bowel diseases? (medscimonit.com)
  • Rheumatic fever and rheumatic heart disease that is caused due to infection and associated inflammatory reactions of the body. (news-medical.net)
  • [ 3 ] Patients with nonuremic calciphylaxis frequently have a history of primary hyperparathyroidism, malignancy, alcoholic liver disease, or underlying connective-tissue disease or pro-inflammatory condition. (medscape.com)
  • IPF is treated with antifibrotic medications, NSIP and S4 are often treated with anti-inflammatory medications, and CHP requires removal of the antigen causing disease. (medscape.com)
  • Nuclear-Factor-Kappa Beta, Cox enzymes, Interleukin-1β, MMP-13, and MMP-2, are all biological agents involved in the inflammatory process that can lead to arthritis, cancer, and Alzheimer's disease. (dragoosoilblends.com)
  • 7] In this article, authors have studied the precision of a dermoscope as a capillaroscopy in evaluating nailfold capillaries in various connective tissue diseases in the skin of color. (cdriadvlkn.org)
  • Rheumatology is a sub-specialty of internal medicine and pediatrics which is concerned with treating conditions affecting joints, connective tissue, soft tissues, autoimmune diseases, and vasculitis. (kernodle.com)
  • Aug 26, 2020·English Chapter 6 Tissues Questions and Answers, Summary, Notes Pdf, KSEEB Solutions for Class 9 Science Karnataka State Board Solutions help you to revise complete Syllabus and score more marks in your examinations. (geertroovers.nl)
  • Examples of connective tissues include cartilage, adipose tissue (fat), blood and bone. (factdr.com)
  • It can exist in liquid form (as in the plasma of blood), gelatinous (in areolar tissue), rubbery (in cartilage) or rigid form (as in bone). (factdr.com)
  • The growth plate is the area of tissue near the ends of long bones in children and teens that determines what length and shape the bone will be once it is done growing. (nih.gov)
  • Performed without a scalpel and sutures, LANAP™ creates an environment for regeneration of the tissues around your teeth (gum, bone, cementum, ligament) that are lost due to periodontal disease. (periocarecarolinas.com)
  • The laser is then used to agitate the healthy tissue, encouraging it to reattach to the bone. (periocarecarolinas.com)
  • However, scarring also affects the heart and kidneys leading to heart and renal failure, the bone marrow leading to blood disease, the pancreas leading to diabetes, the blood vessels leading to strokes and heart attacks and the brain in multiple sclerosis and motor neurone disease. (ukri.org)
  • Some are known such as short telomere syndromes leading to liver, lung and bone marrow scarring and connective tissue disease related scarring in muscle and joint disease. (ukri.org)
  • These studies will address a focused question which will define which groups of scarring diseases are linked by genes that cause telomeres to shorten and cause premature ageing, and are known to be responsible for the known cluster of lung liver and bone marrow scarring. (ukri.org)
  • [1] The disease further leads to gingival bleeding, periodontal pocket formation, connective tissue destruction, and alveolar bone resorption, ultimately causing tooth loss, which is one of the major reasons for tooth loss in adults. (ijohsjournal.org)
  • A connective tissue disease is one that affects tissues such as skin, tendons, and cartilage. (nih.gov)
  • Many studies have shown that WBC can improve the circulation in the skin as well as in the connective tissues, tendons, joints, and muscles. (onlinecancerguide.com)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, 2009: 49pp. (cdc.gov)
  • The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention. (cdc.gov)
  • The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)
  • Advise patients with mixed connective tissue disease to avoid significant cold exposures or to dress accordingly to decrease Raynaud symptoms. (medscape.com)
  • I had some early symptoms of Marfan Syndrome, a disease that affects connective tissues and can be fatal if there is leakage to the vessels that lead to the heart. (dinet.org)
  • What are the symptoms of connective tissue diseases? (helpof.com)
  • Because there are so many different kinds of connective tissue diseases, symptoms may vary and may affect different parts of the body. (helpof.com)
  • The most common symptoms of thyroid disease are red eyes, watery eyes, double vision, bulging eyes, and difficulty closing your eyes. (medium.com)
  • IntroductionAntimitochondrial antibodies (AMAs) are the hallmark of primary biliary cholangitis (PBC) but can be identified also in patients with connective tissue disease, namely, systemic sclerosis (SSc). (ox.ac.uk)
  • Infectious hepatitis includes disease caused by viruses such as A, B, C, and other possible agents of non-A, non-B hepatitis. (cdc.gov)
  • The major cause of liver disease in the United States is ethanol ingestion. (cdc.gov)
  • Purines are in your body's tissues and in foods, such as liver, dried beans and peas, and anchovies. (icdlist.com)
  • Pulmonary arterial hypertension (PAH) is a common and fatal complication of connective tissue diseases (CTDs). (stevefrithphotography.com)
  • Interstitial lung diseases (ILDs), also known as diffuse parenchymal lung diseases, are among the most serious pulmonary complications associated with CTDs. (archivesofmedicalscience.com)
  • A mutation of the body's repair mechanism causes fibrous tissue (including muscle, tendon, and ligament) to be ossified spontaneously or when damaged. (commonplacefacts.com)
  • Katia Bravo Jaimes, M.D., is a board-certified cardiologist with expertise in Adult Congenital Heart Disease. (mayoclinic.org)
  • and Adult Congenital Heart Disease fellowship at the University of California Los Angeles. (mayoclinic.org)
  • Dr. Bravo Jaimes' interest include complex congenital heart disease, heart failure therapies in adults with congenital heart disease, cardio-obstetrics, global health and strategies to mitigate racial disparities in cardiovascular medicine. (mayoclinic.org)
  • IMSEAR at SEARO: Encephalopathy and severe neuropathy due to probable systemic vasculitis as an initial manifestation of mixed connective tissue disease. (who.int)
  • Matsui H, Udaka F, Oda M, Kubori T, Nishinaka K, Kameyama M. Encephalopathy and severe neuropathy due to probable systemic vasculitis as an initial manifestation of mixed connective tissue disease. (who.int)
  • He is a recognized national and international expert on complex medical dermatology, including autoimmune blistering diseases (such as pemphigus and pemphigoid), psoriasis, eczema, rheumatic/connective tissue diseases (such as lupus and dermatomyositis), vasculitis, sarcoidosis, and lichen planus. (ucfhealth.com)
  • Connective tissue disease-associated interstitial lung diseases and interstitial pneumonia with autoimmune features: different entities? (ers-education.org)
  • Studies describing the impact of the microorganisms found in the respiratory tract on lung health have been published and are discussed here in the context of interstitial lung diseases. (frontiersin.org)
  • The four main types are epithelial, muscular, connective and nervous tissues. (factdr.com)
  • Epithelial tissue. (geertroovers.nl)
  • Along with epithelial tissue, muscle tissue, and nervous tissue, connective tissue is one of the four essential forms of animal tissue. (geertroovers.nl)
  • 5. Adipose tissue is also known as: fat cartilage Tissues MCQ Class 9 Science Chapter 6 Simple epithelial tissues are generally classified by the shape of their cells. (geertroovers.nl)
  • The tissue which has minimum intercellular space is epithelial tissue and connective tissue has largest intercellular spaces. (geertroovers.nl)
  • The epithelial tissue has great regeneration power and it is the first evolved tissue. (geertroovers.nl)
  • There can be difficulties relating to the muscles, skin, and joints as a result of connective tissue disease (CTD). (factdr.com)
  • Get the latest scientific news and resources on diseases of the bones, joints, muscles, and skin from the NIAMS. (nih.gov)
  • Diseases characterized by inflammation involving multiple muscles. (bvsalud.org)
  • Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. (bvsalud.org)
  • Fibromyalgia is the disease that affects my muscles and connective tissue amongst other things. (traceysworld.com)
  • Overweight and obesity may act as a permissible factor in musculoskeletal disease, interacting and enhancing the effects of other risk factors, as well as the alignment of the skeleton and the condition of muscles 5-6 . (bvsalud.org)
  • Sjögren's ("SHOW-grins") is a systemic autoimmune disease that affects the entire body. (sjogrens.org)
  • During the opening session the Italian Minister of Health, Beatrice Lorenzin, underlined the huge sense of solitude and loneliness that commonly affects patients with rare diseases and stressed the important role of ERNs in intercepting, helping and taking care of these patients and their families. (brains4brain.eu)
  • Sjögren's syndrome is an autoimmune disease that affects your immune system and parts of the body that produce fluid, such as tears and saliva. (medium.com)
  • Anti-GBM disease is an autoimmune disease in which autoantibodies are directed against type IV collagen in the GBM. (medscape.com)
  • Infiltrative diseases such as sarcoidosis or amyloidosis, and rare genetic diseases such as Wilson disease, primary hemochromatosis, and alpha-1-antitrypsin deficiency, must be excluded. (cdc.gov)
  • Isolated hereditary BBB is an autosomal dominant genetic disease of chromosome 19. (aacnjournals.org)
  • This may reflect advanced disease which is 'beyond repair' or specific genetic interactions with the environmental triggers. (ukri.org)
  • Common genetic, environmental, lifestyle and socioeconomic factors or biological pathways that link these mechanistic clusters aren't readily recognised by conventional disease and organ centred approaches. (ukri.org)
  • ILD is a group of conditions associated with many connective-tissue diseases, said Aryeh Fischer, MD, acting chief of the division of rheumatology at National Jewish Health in Denver. (the-rheumatologist.org)
  • Fellows will work under the mentorship of Gideon P. Smith MD PhD, Director of the Connective Tissue Diseases clinic, a combined effort between the Departments of Dermatology and Rheumatology. (medresidency.com)
  • Fellows will also have the opportunity to participate in patient management in the MGH Connective Tissue Diseases Clinic, collaborating with attendings, fellows, and residents from both dermatology and rheumatology, every week to increase their knowledge of these disease states and to help drive research questions. (medresidency.com)
  • certain localized infections - see body system-related chapters infectious and parasitic diseases complicating pregnancy, childbirth and the puerperium [except obstetrical tetanus] (O98. (who.int)
  • Atypical lymphoid infiltrates arising in cutaneous lesions of connective tissue disease. (ouhsc.edu)
  • Lung diseases -- Physiopathology -- Congresses. (stevefrithphotography.com)
  • Recent studies suggest that the microbiome may serve as a biomarker for disease, a therapeutic target, or provide an explanation for pathophysiology in lung diseases. (frontiersin.org)
  • This paper describes the impact of the microbial communities on the pathogenesis of lung diseases by assessing recent original research and identifying remaining gaps in knowledge. (frontiersin.org)
  • Rituximab and cyclophosphamide were found to be beneficial in the treatment of interstitial lung disease associated with mixed connective tissue disease. (infectiousdiseaseadvisor.com)
  • IMSEAR at SEARO: Connective tissue diseases versus overlap syndrome. (who.int)
  • Overlap connective tissue disease, pulmonary fibrosis, and extensive subcutaneous calcification. (ox.ac.uk)
  • consequently, analyzing biopsied adipose tissue has been used to measure long-term exposure. (cdc.gov)
  • This decrease is evidenced by lower PCB levels reported in human adipose tissue, blood serum, and breast milk [Anderson et al. (cdc.gov)
  • Characterizing the composition of the lung microbiome during disease and elucidating the contribution of the dysbiotic microbiome to disease progression is an area of active research for many respiratory ailments, including ILDs. (frontiersin.org)
  • The objective of the ERN ReCONNET's annual work plan for 2018 is to go on in the work already started during the first year, aimed at improving a community to enhance transnational cooperation between different groups to develop a comprehensive and harmonized approach to rare and complex autoimmune and hereditary connective and musculoskeletal diseases (rCTDs). (europa.eu)
  • Some of these diseases are hereditary. (factdr.com)
  • Some patients have physical findings and laboratory studies that more closely resemble lupus (particularly double-stranded DNA and hypocomplementemia), and treatment should be tailored to treat a lupuslike disease. (medscape.com)
  • Advise patients with mixed connective tissue disease to avoid fatigue. (medscape.com)
  • Depression and anxiety and their association with healthcare utilization in pediatric lupus and mixed connective tissue disease patients: a cross-sectional study. (medscape.com)
  • This study assesses the safety and efficacy of bardoxolone methyl relative to placebo in patients with connective tissue disease-associated pulmonary arterial hypertension to determine the recommended dose range and evaluate the change from baseline in 6-minute walk distance (6MWD) following 24 weeks of study participation. (clinicaltrials.gov)
  • This double-blind, randomized, placebo-controlled trial will study the safety, tolerability, and efficacy of bardoxolone methyl in qualified patients with World Health Organization Group I Connective Tissue Disease Pulmonary Arterial Hypertension (WHO Group I CTD-PAH). (clinicaltrials.gov)
  • WASHINGTON, D.C.-Interstitial lung disease (ILD) is associated with a number of rheumatic diseases, and patients may be referred by pulmonologists to rheumatologists for management. (the-rheumatologist.org)
  • Patients with one of these conditions, especially when associated with connective tissue diseases, often have poor prognoses. (the-rheumatologist.org)
  • If rheumatologists are treating patients with known connective tissue disease, they should take steps to determine if possible ILD is connective tissue disease¬ associated, Dr. Fischer said. (the-rheumatologist.org)
  • Recognition of the exact disease would affect treatment decisions and the prognosis for these patients. (the-rheumatologist.org)
  • Risk factors include patients who are positive for the Scl-70 or U11/U12 RNP antibody and patients with severe esophageal disease, he said. (the-rheumatologist.org)
  • They will revise current pathways recognising what matters in care and the relevance of patients reported outcomes in the disease management. (europa.eu)
  • They will revise current pathways recognizing what matters in care and the relevance of patients reported outcomes in the disease management. (europa.eu)
  • Sixteen consecutive patients with connective tissue diseases were included in the study. (cdriadvlkn.org)
  • In patients with such clinically manifest diseases, changes in the nailfold capillaries may reflect internal organ involvement and helps the clinician to determine the stage of the disease. (cdriadvlkn.org)
  • Pulmonary arterial hypertension is the most common disease-related cause of death in patients with mixed connective tissue disease. (stevefrithphotography.com)
  • Interleukin 9 (IL-9), IL-4 and interferon γ (IFN-γ) - cytokines with important roles in autoimmune disease - were studied in CTD patients and CTD-ILD patients. (archivesofmedicalscience.com)
  • This Editorial introduces the Special Issue on the efficacy and safety of current treatment strategies for patients with connective tissue disease-related interstitial lung disease, including the use of immunosuppressants, such as cyclophosphamide, mycophenolate mofetil and rituximab, and antifibrotic drugs. (zaphod.dev)
  • Given its slow progression, painless nature, ignorance about the disease and its causes, and scarcity of medical and health facilities in the areas where it occurs, many patients present late with advanced disease, when amputation may be the only available treatment. (who.int)
  • The ERNs´/MS National Health Systems/National Plans for Rare Diseases integration is instrumental to define strategies to optimize the cost of management of patients of rare diseases. (brains4brain.eu)
  • This system allows to ensure better performance for a better quality of life for patients and at at the same time lower healthcare costs as highlighted by Paola Facchin (Interregional Table for Rare Diseases) who highlighted the importance of the support provided by the Ministry of Health to the Italian Centers in entering in the European context. (brains4brain.eu)
  • Association of Calcium Phosphorus Product and Coronary Artery Calcification in End Stage Renal Disease Patients on Dialysis. (aimdrjournal.com)
  • Patients with Stage I bladder cancer have a cancer that invades the subepithelial connective tissue, but does not invade the muscle of the bladder and has not spread to lymph nodes. (cancerconnect.com)
  • The Department of Dermatology at Massachusetts General Hospital, a flagship teaching hospital of Harvard Medical School, offers a 1-year Fellowship in Connective Tissue Diseases. (medresidency.com)
  • Yoshida S. Pulmonary arterial hypertension in connective tissue diseases. (medscape.com)
  • When it accompanies other diseases, it is called secondary Raynaud's phenomenon. (medicinenet.com)
  • IPF (n=117), FIP (n=54), iNSIP (n=34), NSIP secondary to connective tissue disease (NSIP_CTD, n=32) and a healthy subjects cohort (n=249) were genotyped for MUC5B rs35705950. (ersjournals.com)
  • Bronchiectasis is an uncommon disease, most often secondary to an infectious process, that results in the abnormal and permanent distortion of one or more of the conducting bronchi or airways. (medscape.com)
  • This is a systemic disease that is also capable of adversely affecting the cardiovascular and respiratory systems. (factdr.com)
  • However, recent advances in microbial sequencing techniques suggest that a variety of microbial organisms dwell in both the upper and lower respiratory tract and that composition of this microbial community is altered in respiratory disease states ( 12 ). (frontiersin.org)