A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.
Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.
Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
A collective term for diseases of the skin and its appendages and of connective tissue.
Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
The protein components that constitute the common core of small nuclear ribonucleoprotein particles. These proteins are commonly referred as Sm nuclear antigens due to their antigenic nature.
A mild form of LIMITED SCLERODERMA, a multi-system disorder. Its features include symptoms of CALCINOSIS; RAYNAUD DISEASE; ESOPHAGEAL MOTILITY DISORDERS; sclerodactyly, and TELANGIECTASIS. When the defect in esophageal function is not prominent, it is known as CRST syndrome.
A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)
A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.
Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES.
Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.
Implants used to reconstruct and/or cosmetically enhance the female breast. They have an outer shell or envelope of silicone elastomer and are filled with either saline or silicone gel. The outer shell may be either smooth or textured.
Inflammation of a muscle or muscle tissue.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U1 snRNP along with other small nuclear ribonucleoproteins (U2, U4-U6, and U5) assemble into SPLICEOSOMES that remove introns from pre-mRNA by splicing. The U1 snRNA forms base pairs with conserved sequence motifs at the 5'-splice site and recognizes both the 5'- and 3'-splice sites and may have a fundamental role in aligning the two sites for the splicing reaction.
Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.
Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)
A form of necrotizing non-granulomatous inflammation occurring primarily in medium-sized ARTERIES, often with microaneurysms. It is characterized by muscle, joint, and abdominal pain resulting from arterial infarction and scarring in affected organs. Polyarteritis nodosa with lung involvement is called CHURG-STRAUSS SYNDROME.
A term used to describe a variety of localized asymmetrical SKIN thickening that is similar to those of SYSTEMIC SCLERODERMA but without the disease features in the multiple internal organs and BLOOD VESSELS. Lesions may be characterized as patches or plaques (morphea), bands (linear), or nodules.
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
Mucoid states characterized by the elevated deposition and accumulation of mucin (mucopolysaccharides) in dermal tissue. The fibroblasts are responsible for the production of acid mucopolysaccharides (GLYCOSAMINOGLYCANS) in the ground substance of the connective tissue system. When fibroblasts produce abnormally large quantities of mucopolysaccharides as hyaluronic acid, chondroitin sulfate, or heparin, they accumulate in large amounts in the dermis.
Highly conserved nuclear RNA-protein complexes that function in RNA processing in the nucleus, including pre-mRNA splicing and pre-mRNA 3'-end processing in the nucleoplasm, and pre-rRNA processing in the nucleolus (see RIBONUCLEOPROTEINS, SMALL NUCLEOLAR).
Complexes of RNA-binding proteins with ribonucleic acids (RNA).
Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.
The thin, horny plates that cover the dorsal surfaces of the distal phalanges of the fingers and toes of primates.
A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)
A group of interstitial lung diseases with no known etiology. There are several entities with varying patterns of inflammation and fibrosis. They are classified by their distinct clinical-radiological-pathological features and prognosis. They include IDIOPATHIC PULMONARY FIBROSIS; CRYPTOGENIC ORGANIZING PNEUMONIA; and others.
An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
The noninvasive microscopic examination of the microcirculation, commonly done in the nailbed or conjunctiva. In addition to the capillaries themselves, observations can be made of passing blood cells or intravenously injected substances. This is not the same as endoscopic examination of blood vessels (ANGIOSCOPY).
Any one of five terminal digits of the vertebrate FOOT.
The branch of surgery concerned with restoration, reconstruction, or improvement of defective, damaged, or missing structures.
A multisystemic disease of a complex genetic background. It is characterized by inflammation of the blood vessels (VASCULITIS) leading to damage in any number of organs. The common features include granulomatous inflammation of the RESPIRATORY TRACT and kidneys. Most patients have measurable autoantibodies (ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES) against neutrophil proteinase-3 (WEGENER AUTOANTIGEN).
Small RNAs found in the cytoplasm usually complexed with proteins in scRNPs (RIBONUCLEOPROTEINS, SMALL CYTOPLASMIC).
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
A chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydroxychloroquine appears to concentrate in food vacuoles of affected protozoa. It inhibits plasmodial heme polymerase. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p970)
Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.
Fluid accumulation within the PERICARDIUM. Serous effusions are associated with pericardial diseases. Hemopericardium is associated with trauma. Lipid-containing effusion (chylopericardium) results from leakage of THORACIC DUCT. Severe cases can lead to CARDIAC TAMPONADE.
Disorders of one or more of the twelve cranial nerves. With the exception of the optic and olfactory nerves, this includes disorders of the brain stem nuclei from which the cranial nerves originate or terminate.
Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.
Immunoelectrophoresis in which immunoprecipitation occurs when antigen at the cathode is caused to migrate in an electric field through a suitable medium of diffusion against a stream of antibody migrating from the anode as a result of endosmotic flow.
A primary systemic vasculitis of small- and some medium-sized vessels. It is characterized by a tropism for kidneys and lungs, positive association with anti-neutrophil cytoplasmic antibodies (ANCA), and a paucity of immunoglobulin deposits in vessel walls.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
An interstitial lung disease of unknown etiology, occurring between 21-80 years of age. It is characterized by a dramatic onset of a "pneumonia-like" illness with cough, fever, malaise, fatigue, and weight loss. Pathological features include prominent interstitial inflammation without collagen fibrosis, diffuse fibroblastic foci, and no microscopic honeycomb change. There is excessive proliferation of granulation tissue within small airways and alveolar ducts.
Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).
Four or five slender jointed digits in humans and primates, attached to each HAND.
Refers to any inflammation of the sclera including episcleritis, a benign condition affecting only the episclera, which is generally short-lived and easily treated. Classic scleritis, on the other hand, affects deeper tissue and is characterized by higher rates of visual acuity loss and even mortality, particularly in necrotizing form. Its characteristic symptom is severe and general head pain. Scleritis has also been associated with systemic collagen disease. Etiology is unknown but is thought to involve a local immune response. Treatment is difficult and includes administration of anti-inflammatory and immunosuppressive agents such as corticosteroids. Inflammation of the sclera may also be secondary to inflammation of adjacent tissues, such as the conjunctiva.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.
Proteins conjugated with nucleic acids.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Immunologically detectable substances found in the CELL NUCLEUS.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.
Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Rare chronic inflammatory disease involving the small blood vessels. It is of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon. The neuro-ocular form may cause blindness and death. SYNOVITIS; THROMBOPHLEBITIS; gastrointestinal ulcerations; RETINAL VASCULITIS; and OPTIC ATROPHY may occur as well.
Compression of the heart by accumulated fluid (PERICARDIAL EFFUSION) or blood (HEMOPERICARDIUM) in the PERICARDIUM surrounding the heart. The affected cardiac functions and CARDIAC OUTPUT can range from minimal to total hemodynamic collapse.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
A PREDNISOLONE derivative with similar anti-inflammatory action.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

Silicone breast implants: epidemiological evidence of sequelae. (1/463)

Skeptics may certainly find fault with the third study (the only one to report a significant finding) or with all or any of the statistics described. But few could argue, after examining these studies, that the relative risk for a known and well-defined connective tissue disease is likely greater than 2. Another possibility has been raised, one that calls to mind other difficult-to-study syndromes linked to exposures. In a study addressing Gulf War syndrome, signs and symptoms were often mentioned that proved difficult to describe systematically and therefore difficult to study. What if a suspected silicone exposure syndrome were so mild and transient that it did not warrant a physician visit (as in the Mayo Clinic study). receive a diagnosis (as in the Nurses' Health Study), or require admission to a hospital (as in the Danish and Swedish studies)? And if such a disorder were, in fact, mild and transient, should it merit the concern that has been shown and the compensation that has been awarded in the silicone implant litigation cases to date? We suggest that neither a well-described disorder with a relative risk of less than 2 nor a transient and mild disorder seems compatible with the number of litigants over silicone implants and the apparent seriousness of their complaints. Some 400,000 women joined in one class action suit for damages, and 170,000 joined in another. Even if there had been 2 million implants undertaken in the United States over the 3 decades in which implant surgery has been practiced (and some estimates put the number closer to 1 million), there is no conceivable way in which a relative risk of 2 or 3 (or even 4) for each of the rare syndromes reported could explain so many exposed women being affected. At most, 2200 out of 2 million unexposed women would be expected to have had any one of the listed forms of connective tissue disorders, most of which are very rare. Doubling the risk among the exposed population yields 4400, and increasing the risk 20-fold produces 44,000. At this rate, there is no way in which 400,000 litigants could all be affected. Extensions of the already-completed studies are ongoing, at least 1 of which is government funded; apparently it is thought in the United States (though not in the United Kingdom or elsewhere) that there is still room for reasonable doubt as to the supposed causal relationships. But if epidemiology is invoked in the interest of public health to prevent the many uses of silicone, the weight of the evidence abstracted here supports the inference that silicone breast implants have not been proved guilty of causing connective tissue disorders.  (+info)

Pulmonary artery pressure variation in patients with connective tissue disease: 24 hour ambulatory pulmonary artery pressure monitoring. (2/463)

BACKGROUND: The specific contribution of secondary pulmonary hypertension to the morbidity and mortality of patients with underlying lung disease can be difficult to assess from single measurements of pulmonary artery pressure. We have studied patients with secondary pulmonary hypertension using an ambulatory system for measuring continuous pulmonary artery pressure (PAP). We chose to study patients with connective tissue disease because they represent a group at high risk of pulmonary vascular disease, but with little disturbance of lung function. METHODS: Six patients (five with progressive systemic sclerosis and one with systemic lupus erythematosis) were studied. They underwent preliminary cardiopulmonary investigations followed by Doppler echocardiography, right heart catheterisation, and ambulatory pulmonary artery pressure monitoring to measure changes in pressure over a 24 hour period including during a formal exercise test. RESULTS: All patients had pulmonary hypertension as measured by Doppler echocardiography with estimated pulmonary artery systolic pressures of 40-100 mm Hg. Pulmonary function testing revealed virtually normal spirometric values (mean FEV1 86.9% predicted) but marked reduction in CO gas transfer factor (KCO 57.8% predicted). Exercise responses were impaired with mean VO2max 50.6% predicted. Ambulatory PAP monitoring indicated significant changes in pressures with variation in posture and activity throughout 24 hours. Resting PAP did not predict the change in PAP seen on exercise. CONCLUSION: Conventional methods of assessment of the pulmonary circulation based on single measurements in the supine position may underestimate the stresses faced by the right side of the circulation. This ambulatory system allows monitoring of pulmonary haemodynamics continuously over 24 hours during normal activities of daily living. These measurements may increase our understanding of the contribution made by secondary pulmonary hypertension to the morbidity and mortality of the underlying lung disease.  (+info)

Petroleum distillate solvents as risk factors for undifferentiated connective tissue disease (UCTD). (3/463)

Occupational solvent exposure may increase the risk of connective tissue disease (CTD). The objective of this case-control study was to investigate the relation between undifferentiated connective tissue disease (UCTD) and solvent exposure in Michigan and Ohio. Women were considered to have UCTD if they did not meet the American College of Rheumatology classification criteria for any CTD but had at least two documented signs, symptoms, or laboratory abnormalities suggestive of a CTD. Detailed information on solvent exposure was ascertained from 205 cases, diagnosed between 1980 and 1992, and 2,095 population-based controls. Age-adjusted odds ratios (OR) and 95 percent confidence intervals (CI) were calculated for all exposures. Among 16 self-reported occupational activities with potential solvent exposure, furniture refinishing (OR = 9.73, 95 percent CI 1.48-63.90), perfume, cosmetic, or drug manufacturing (OR = 7.71, 95 percent CI 2.24-26.56), rubber product manufacturing (OR = 4.70, 95 percent CI 1.75-12.61), work in a medical diagnostic or pathology laboratory (OR = 4.52, 95 percent CI 2.27-8.97), and painting or paint manufacturing (OR = 2.87, 95 percent CI 1.06-7.76) were significantly associated with UCTD. After expert review of self-reported exposure to ten specific solvents, paint thinners or removers (OR = 2.73, 95 percent CI 1.80-4.16) and mineral spirits (OR = 1.81, 95 percent CI 1.09-3.02) were associated with UCTD. These results suggest that exposure to petroleum distillates increases the risk of developing UCTD.  (+info)

Up-regulation of intercellular adhesion molecule-1 (ICAM-1), endothelial leucocyte adhesion molecule-1 (ELAM-1) and class II MHC molecules on pulmonary artery endothelial cells by antibodies against U1-ribonucleoprotein. (4/463)

In order to elucidate the pathogenic role(s) of autoantibodies in connective tissue disease (CTD), we examined whether autoantibodies against U1-ribonucleoprotein (RNP) and double-stranded (ds) DNA can up-regulate ICAM-1, ELAM-1 and class I and II MHC molecule expression on pulmonary artery endothelial cells (HPAEC). ICAM-1, ELAM-1 and class II MHC molecule expression on HPAEC cultured in the presence of anti-U1-RNP-containing and anti-dsDNA-containing IgG from CTD patients was up-regulated significantly in comparison with that on HPAEC cultured with IgG from normal healthy volunteers. Affinity chromatographic enrichment and depletion of the anti-U1-RNP antibody content of anti-U1-RNP-containing IgG confirmed that the anti-U1-RNP antibody did up-regulate ICAM-1, ELAM-1 and class II MHC molecule expression. The finding that an IgG F(ab')2-purified anti-U1-RNP antibody also up-regulated expression of these molecules may indicate that mechanisms other than Fc receptor-mediated stimulation are involved. These in vitro findings suggest that autoantibodies against U1-RNP and dsDNA play important roles in the immunopathological processes leading to the proliferative pulmonary arterial vasculopathy observed in CTD patients with pulmonary hypertension by up-regulating adhesion and class II MHC molecule expression on endothelial cells.  (+info)

T cell receptor beta-chain third complementarity-determining region gene usage is highly restricted among Sm-B autoantigen-specific human T cell clones derived from patients with connective tissue disease. (5/463)

OBJECTIVE: To determine the structure of T cell receptors (TCR) used by Sm-B-reactive human T cell clones, to map T cell epitopes on the Sm-B autoantigen, and to determine the HLA restriction element used in the recognition of Sm-B by T cells. METHODS: Sm-B-reactive T cell clones were generated from patients with connective tissue disease by using either a recombinant fusion protein or synthetic peptides. The TCR structure was defined with the use of polymerase chain reaction and DNA sequencing. Synthetic peptides were used to map T cell epitopes on Sm-B. HLA restriction element usage was defined by using monoclonal antibody blocking. RESULTS: Usage of the TCR third complementarity-determining region (CDR3) was highly restricted among Sm-B autoantigen-specific human T cell clones. Only amino acids 48-96 of the Sm-B2 autoantigen were recognized by T cells, and this occurred in the context of HLA-DR. CONCLUSION: TCR CDR3 gene usage is highly conserved by Sm-B autoantigen-specific T cell clones, and this appears to be related to the recognition of a limited number of T cell epitopes on the Sm-B autoantigen presented in the context of HLA-DR.  (+info)

Pneumocystis carinii pneumonia in patients with connective tissue diseases: the role of hospital experience in diagnosis and mortality. (6/463)

OBJECTIVE: Pneumonia due to Pneumocystis carinii has been increasingly reported in patients with connective tissue diseases, but the frequency of this complication is not known. We sought to determine the frequency of P carinii pneumonia (PCP) in patients with connective tissue diseases, and to determine the role that a hospital's acquired immunodeficiency syndrome (AIDS)-related experience may have in the diagnosis of PCP in these patients. METHODS: We used a state hospitalization registry to identify all patients with PCP and either rheumatoid arthritis, systemic lupus erythematosus, Wegener's granulomatosis, polymyositis, dermatomyositis, polyarteritis nodosa, or scleroderma who had an emergent or urgent hospitalization in California from 1983 to 1994. We compared patient and hospital characteristics between these patients and patients with connective tissue diseases hospitalized with other types of pneumonia. RESULTS: Two hundred twenty-three patients with connective tissue diseases were diagnosed with PCP in the 12-year study period. The frequency of PCP ranged from 89 cases/10,000 hospitalizations/year in patients with Wegener's granulomatosis to 2 cases/10,000 hospitalizations/year in patients with rheumatoid arthritis. Compared with 5,457 patients with connective tissue diseases and pneumonia due to other organisms, patients with PCP were more likely to be younger, to be male, to have private medical insurance, and to have systemic lupus erythematosus, Wegener's granulomatosis, inflammatory myopathy, or polyarteritis nodosa rather than rheumatoid arthritis, and were less likely to be African American. Hospital size, teaching status, urban/rural location, proportion of admissions due to AIDS or PCP, and proportion of patients with pneumonia undergoing bronchoscopy were each associated with the likelihood of diagnosis of PCP in univariate analyses, but only the number of patients with PCP being treated at a hospital (odds ratio [OR] 1.03 for each additional 10 cases/year, 95% confidence interval [95% CI] 1.01-1.05) was associated with the likelihood of diagnosis of PCP in multivariate analyses. Patients were also somewhat more likely to be diagnosed with PCP if there had previously been a case of PCP in a patient with a connective tissue disease at the same hospital (OR 135, 95% CI 0.98-1.85). In-hospital mortality was 45.7%, and was unrelated to hospital characteristics. CONCLUSION: PCP is an uncommon, but often fatal, occurrence in patients with connective tissue disease. A hospital's prior experience with patients with PCP is associated with the likelihood that this condition is diagnosed in patients with connective tissue diseases who present with pneumonia, suggesting that diagnostic suspicion is an important factor in the correct identification of affected patients.  (+info)

Joint hypermobility and genetic collagen disorders: are they related? (7/463)

The HDCTs constitute a heterogeneous group of rare genetically determined diseases, the best known of which are Ehlers-Danlos and Marfan syndromes and osteogenesis imperfecta. Hypermobility is a feature common to them all, but it is also a feature that is highly prevalent in the population at large. Symptomatic hypermobile subjects (whose symptoms are attributable to their hypermobility) are said to be suffering from the benign joint hypermobility syndrome, which has many features that overlap with the HDCTs. It is not yet known whether there is a variety of hypermobility (symptomatic or otherwise) that is not part of a connective tissue disorder.  (+info)

111Indium antimyosin antibody imaging of primary myocardial involvement in systemic diseases. (8/463)

OBJECTIVE: The diagnosis of primary myocardial involvement in systemic diseases is clinically relevant but difficult in the absence of specific criteria. Whatever the underlying disease, myocytes degeneration is observed during the active phase of myocardial damage. The aim of this study was to assess the diagnostic value of scintigraphic imaging with 111Indium antimyosin antibody (AM), a specific marker of the damaged myocyte, for ongoing myocardial damage related to systemic diseases. METHODS: 40 patients with histologically confirmed systemic diseases were studied. They were classified into two groups according to the presence (group 1, n = 30), or the absence (group 2, n = 10) of clinical, electrocardiographic (ECG) or echocardiographic signs suggestive of myocardial involvement. Planar and tomographic acquisitions were obtained 48 hours after injection of AM (90 MBq). Rest 201thallium (T1) scintigraphy was also performed to assess myocardial perfusion and scarring. Clinical, ECG, and echocardiographic +/- scintigraphic evaluations were repeated during follow up (17 +/- 19 months) in 36 of 40 patients. RESULTS: In group 1, 13 of 30 patients (43%) showed diffuse significant AM uptake throughout the left ventricle (LV), and no or mild T1 abnormality. Two of these were asymptomatic, four had normal ECG, and two had no clinical or echographic LV dysfunction. All patients in group 2 had negative AMA scintigraphy and normal T1 scintigraphy. During follow up of 12 AM positive patients, cardiac status improved after immunosuppressive treatment was intensified in nine cases, worsened in two cases, and remained stable in one. During follow up of 24 AM negative patients, cardiac status remained stable in 23 cases despite treatment not being increased in 20, including two patients with sequellary myocardial involvement. The last patient developed mild LV dysfunction after 36 months. CONCLUSION: AM scintigraphy allows detection of active myocardial damage related to systemic diseases, with increased specificity compared with conventional methods, and increased sensitivity in some cases. Further studies are needed to assess the potential value of AM scintigraphy as a therapeutic guide.  (+info)

TY - JOUR. T1 - Connective tissue disease-associated interstitial lung diseases (CTD-ILD) - Report from OMERACT CTD-ILD working group. AU - Khanna, Dinesh. AU - Mittoo, Shikha. AU - Aggarwal, Rohit. AU - Proudman, Susanna M.. AU - Dalbeth, Nicola. AU - Matteson, Eric L.. AU - Brown, Kevin. AU - Flaherty, Kevin. AU - Wells, Athol U.. AU - Seibold, James R.. AU - Strand, Vibeke. N1 - Publisher Copyright: The Journal of Rheumatology Copyright © 2015. All rights reserved. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.. PY - 2015/11. Y1 - 2015/11. N2 - Objective. Interstitial lung disease (ILD) is common in connective tissue disease (CTD) and is the leading cause of mortality. Investigators have used certain outcome measures in randomized controlled trials (RCT) in CTD-ILD, but the lack of a systematically developed, CTD-specific index that captures all measures relevant and meaningful to patients with CTD-ILD has left a large and conspicuous gap in CTD-ILD research. Methods. The ...
P1: Possibility when comparing CTD-ILD group and UCTD-ILD group. P2: Possibility when comparing CTD-ILD group and IPF group. P3: Possibility when comparing UCTD-ILD group and IPF group ...
There are complex interactions between connective tissue disease (CTD) and interstitial lung disease (ILD), particularly in the PH patient. Clinicians that care for these patients will benefit from a deeper understanding of CTD and the ILD aspects of this diverse spectrum of disease. There are many clinical dilemmas to address and this course will focus on an approach to the evaluation and management of CTD-associated ILD.
From BioPortfolio: Interstitial lung disease (ILD) is a major pulmonary manifestation of connective tissue disease (CTD), leading to significant morbidity and mortality. Chest hig...
Undifferentiated connective tissue diseases (UCTDs) are clinical entities characterised by signs and symptoms suggestive of a systemic autoimmune disease, which do not fulfil the diagnostic criteria for a defined connective tissue disease. Lung involvement can complicate the course and management of the disease, often determining a worse outcome. Respiratory dysfunction as the first clinical manifestation has seldom been reported. We describe a case of a female patient who developed significant respiratory dysfunction as the principal clinical sign. Video-assisted thoracoscopy was performed and a histological pattern of nonspecific interstitial pneumonia (NSIP) was found. A pathological diagnosis suggested careful follow-up with extensive immunological screening which then detected Raynauds phenomenon and positivity of antinuclear antibodies. After a multidisciplinary discussion (pneumologist, radiologist, pathologist and rheumatologist) a final diagnosis of NSIP associated with UCTD was made. The
What is CTD-ILD? Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a lung disease that may happen to some people with a connective tissue disease.
How undifferentiated connective tissue disease (UCTD) is diagnosed through its symptoms, family history, physical examination, x-rays, and CT scans.
(Update) Donna C: Undifferentiated Connective Tissue Disease (UCTD) For the most part I have still been doing very good. Some little setbacks here and there...
Objective. To review the diagnoses after 5 years in patients who were identified within 12 months of the onset of well established and undifferentiated connective tissue diseases CTD ; to examine death rates and disease remissions in these patients. Methods. This inception cohort of 410 patients was identified in 10 academic rheumatology...
Undifferentiated Connective Tissue Disease stories from our community of patients. Read how these patients from all walks of life got back into their game of life.
Objective: To investigate the timing and complications of lung transplantation for the treatment of connective tissue disease-associated interstitial lung disease (CTD-ILD). Method: The clinical data of connective tissue-associated disease lung transplantation recipients from September, 2015 to February, 2017 were collected. Results: 11 patients with CTD-ILD were evaluated by lung transplantation and were treated with lung transplantation. Including 2 cases dermatomyositis/polymyositis and interstitial lung disease (PM/DM-ILD), 4 cases rheumatoid arthritis and interstitial lung disease (RA-ILD), 4 cases of primary Sjgrens syndrome and interstitial lung disease (pSS-ILD), 1 case of systemic sclerosis and interstitial lung disease (SSc-ILD ...
Dr. Antin-Ozerkis received her Bachelors degree from Princeton University. She went on to complete her medical degree, residency, and fellowship in Pulmonary and Critical Care Medicine at the University of Pennsylvania, where she pursued advanced fellowship training in the evaluation and management of advanced lung disease and lung transplant patients. She came to Yale in 2006. Dr. Antin-Ozerkis is Medical Director of the Yale Interstitial Lung Disease Center of Excellence. Her specific area of clinical expertise is the diagnosis and treatment of interstitial lung diseases (ILD), with a focus on idiopathic pulmonary fibrosis (IPF) and connective tissue disease-associated interstitial lung disease (CTD-ILD). She leads a multidisciplinary group which meets weekly to review patient cases, offering consensus opinions on diagnosis and management. As part of a comprehensive approach to patient care, Yale ILD offers clinical drug trials for patients with IPF and other forms of pulmonary fibrosis. Dr. ...
ICD M30-M36 Systemic connective tissue disorders  autoimmune disease NOS collagen (vascular) disease NOS systemic autoimmune disease systemic collagen
Trigeminal neuralgia - Connective tissue disease Factor. Last reviewed for CCPS 10 March 1995.. Preliminary questions [8154]. 8603 [1] there is some evidence that a connective tissue disease may be a factor in the development of the condition under consideration.. 8184 - the veteran has suffered from a connective tissue disease at some time.. 6563 [2] the veteran has had scleroderma at some time.. or. 8615 [3] the veteran has had Sjogrens syndrome at some time.. or. 2576 [4] the veteran has had systemic lupus erythematosus at some time.. or. [5]8616. the veteran has had dermatomyositis at some time.. or. 8617 [6] the veteran has had mixed connective tissue disease at some time.. 8186 [7] the veteran suffered from the identified illness or injury, a connective tissue disease, prior to the clinical onset of trigeminal neuralgia. [8]. 8187 - the veteran has established the causal connection between the identified illness or injury, a connective tissue disease, and operational service for the ...
Study shows HHV-6 reactivation is disproportionately elevated among patients with autoimmune connective tissue disease. A new study from Italy indicates that HHV-6 reactivation is selectively increased among patients suffering from autoimmune connective tissue diseases (ACTD). Low levels of HHV-6 DNA were detected in the serum of 26% of ACTD patients, which was significantly greater than that observed amongst controls (P , 0.0002). The authors used a highly sensitive assay and the median viral load for these patients was under 100 copies/ml, which would fall below the current level of detection at most clinical laboratories. The group also found a significant association between HHV-6 reactivation and the active disease state for lupus erythematosus (P = 0.021). By contrast, the rate of EBV viremia was similar in patients and controls groups, while CMV, HHV-8, and parvovirus B19 viremia was not detected in any subject.. In the paper, published in the Journal of Medical Virology this month, the ...
This week, I was called to evaluate a young man with several aneurysms (ballooning of his blood vessels) and a dilated (widened) aorta. The medical team thought he had a connective tissue disease because a family member also had a connective tissue disease-she had lupus. Unfortunately, doctors can mean very different things when they talk about a connective tissue disease; this is a common source of confusion for doctors and patients alike. After reading this post, I hope youll be able understand the difference.. Connective tissue is the stuff that holds your body together. That is, the bones, ligaments, tendons, cartilage, fat, and glue that keeps all your organs in place. Two very different types of diseases can affect these tissues-you can have problems in MAKING the connective tissues, or these tissues can be ATTACKED by the bodys own immune system.. In the first type of connective tissue disease, the body is unable to produce strong connective tissues. Its like trying to build ...
Complex Treatment of Children Affected by Undifferentiated Connective Tissue Dysplasia Combined with Bone Mineral Density Reduction
Complex Treatment of Children Affected by Undifferentiated Connective Tissue Dysplasia Combined with Bone Mineral Density Reduction
The conceptual study of connective tissue diseases as one of causative factors in Interstitial lung diseases (ILDs) : both modern and ayurveda perspective ;patients with ILDs come with the onset of progressive exertional dyspnea or a persistent nonproductive cough. Hemoptysis , wheezing and chest pain may be present. Often , the identification of interstitial opacities on chest X-ray focuses the diagnostic approach on one of the ILDs. Rheumatoid arthritis is one of connective and autoimmune diseases which cause ILDs.. inflammation in the air space and alveolar walls and interstitial fibrosis are present due to autoimmunity.. the presence of jts pain , stiffness and deformity like swan neck etc with +ve antinuclear antibodies and anti- immunoglobulin antibodies ( RA factors ) confirm the diagnosis , however these tests are +ve even in absence of defined connective tissue diseases. ILDs are characterized as a significant part of a multiorgan process , as may occur in the connective tissue diseases ...
TY - JOUR. T1 - T cell immunity in connective tissue disease patients targets the RNA binding domain of the U1-70kDa small nuclear ribonucleoprotein. AU - Greidinger, Eric L.. AU - Foecking, Mark F.. AU - Schäfermeyer, Kim R.. AU - Bailey, Craig W.. AU - Primm, Shannon L.. AU - Lee, David R.. AU - Hoffman, Robert W.. PY - 2002/9/15. Y1 - 2002/9/15. N2 - Although the T cell dependence of autoimmune responses in connective tissue diseases has been well established, limited information exists regarding the T cell targeting of self Ags in humans. To characterize the T cell response to a connective tissue disease-associated autoantigen, this study generated T cell clones from patients using a set of peptides encompassing the entire linear sequence of the 70-kDa subunit of U1 snRNP (U1-70kDa) small nuclear ribonucleoprotein. Despite the ability of U1-70kDa to undergo multiple forms of Ag modification that have been correlated with distinct clinical disease phenotypes, a remarkably limited and ...
What exactly is connective tissue disease? Connective tissue diseases are referred to as a group of medical diseases. A connective tissue disease has
A total of 187 specimens from 142 subjects with rheumatoid arthritis, systemic lupus erythematosus, other connective tissue diseases, and controls were placed in cell culture. Specimens from 119 of the subjects grew, lasting over 2 yr in several instances. No evidence of virus infection has been found by a variety of sensitive methods, including cell fusion. Other approaches have likewise failed thus far to implicate any virus in the pathogenesis of rheumatoid arthritis.. ...
Connective tissue diseases by Graham R. V. Hughes; 4 editions; First published in 1977; Subjects: Collagen diseases, Connective Tissue Diseases, Connective Tissue, Diseases, Connective tissues, Internet Archive Wishlist
TY - JOUR. T1 - The short-term role of corticosteroid therapy for pulmonary arterial hypertension associated with connective tissue diseases. T2 - Report of five cases and a literature review. AU - Kato, M.. AU - Kataoka, H.. AU - Odani, T.. AU - Fujieda, Y.. AU - Otomo, Kotaro. AU - Oku, K.. AU - Horita, T.. AU - Yasuda, S.. AU - Atsumi, T.. AU - Ohira, H.. AU - Tsujino, I.. AU - Nishimura, M.. AU - Koike, T.. PY - 2011/10/1. Y1 - 2011/10/1. N2 - Pulmonary arterial hypertension (PAH) is a life-threatening complication in connective tissue diseases (CTD). It remains controversial whether immunosuppressive therapy is useful for PAH associated with CTD (PAH-CTD). The Dana Point algorithm does not refer such treatments in patients with PAH-CTD due to the lack of evidence. However, some case reports have shown the potential efficacy of immunosuppression for PAH-CTD. Here we report five cases of PAH-CTD treated with corticosteroids and discuss the current management of PAH-CTD with immunosuppressive ...
ILD is most commonly found in systemic sclerosis at a prevalence rate of 25% to 90%, Dr. Fischer said. It is also found less frequently in polymyositis and dermatomyositis, RA, Sjögrens syndrome, and systemic lupus erythematosus. If rheumatologists are treating patients with known connective tissue disease, they should take steps to determine if possible ILD is connective tissue disease¬ associated, Dr. Fischer said. Recognition of the exact disease would affect treatment decisions and the prognosis for these patients. Its important for the patients outcome to see where they fit, he said.. ...
Aortic stenosis, hypertrophic obstructive cardiomyopathy, cerebrovascular and cardiovascular diseases (including cerebrovascular insufficiency, coronary heart disease, coronary insufficiency - a risk of excessive blood pressure lowering and concomitant ischemia). Severe autoimmune systemic connective tissue disease (including systemic lupus erythematosus, scleroderma), inhibition of bone marrow hematopoiesis in patients receiving immunosuppressive drugs (increasing the likelihood of neutropenia). Renovascular • Read More ». ...
Garen, Torhild Oddveig; Lerang, Karoline; Hoffmann-Vold, Anna-Maria; Andersson, Anna Helena; Midtvedt, Øyvind; Brunborg, Cathrine; Kilian, Karin Renate; Gudbrandsson, Birgir Mar; Gunnarsson, Ragnar; Norby, Gudrun; Chaudhary, Asad; Thoen, Jørn; Forseth, Karin Maria Øien; Fresjar, Kari; Førre, Øystein Thorleiv; Haugen, Margaretha; Haga, Hans-Jacob; Gran, Jan Tore; Gilboe, Inge-Margrethe; Molberg, Øyvind & Palm, Øyvind (2019). Mortality and causes of death across the systemic connective tissue diseases and the primary systemic vasculitides. Rheumatology. ISSN 1462-0324. 58(2), s 313- 320 . doi: 10.1093/rheumatology/key285 ...
In this study, 82 photomacrographs of nailfold capillary beds from 60 patients with scleroderma spectrum disorders (scleroderma, undifferentiated connective tissue disease, and dermatomyositis) and from 16 normal controls were analyzed blindly, using both semiquantitative and quantitative methods, t …
Results 215 pregnancies in 184 women were included and classified according to mothers autoimmune disease: 52 (24,2%) Primary Antiphospholipid Syndrome (PAPS), 26 (12,1%) with only Antiphospholipid Antibodies (APA), 27 (12,6%) Systemic Erythematosus Lupus (SLE), 28 (13%) SLE with APA, 44 (20,5%) Undifferentiated Connective Tissue Disease (UCTD) and 38 (17,7%) UCTD with APA. A total of 41 (19,06%) miscarriages were reported, 32 (14,8%) in the first 10 weeks of pregnancy and 9 (4.18%) beyond that 10th week. Risk factors for miscarriages in the univariate analysis were mothers age, lupus anticoagulant, IgG and IgM anticardiolipin antibodies, previous miscarriages and PAPS, while UCTD was a protective factor. In the multivariate model only mothers age (OR 0.9, IC 95% 0.8-0.98), lupus anticoagulant (OR 2.5, IC 95% 1.1-5.4), IgG anticardiolipin (OR 4.0, IC 95% 1.8-9.0) and previous miscarriages (OR 2.8, IC 95% 1.2-6.5) were predictors. A Miscarriage Risk Score ranging between 0 and 11 points was ...
Background/Purpose: Patients with Systemic Autoimmune Rheumatic Disease (SARD) often have a prolonged pre-clinical phase during which they are anti-nuclear antibody (ANA) positive but lack clinical symptoms. It has been proposed that progression from asymptomatic autoimmunity to clinical disease is accompanied by immunologic changes that could be used as predictors of disease development. Our objective was to identify cyto/chemokine abnormalities in ANA+individuals who lack sufficient criteria for a diagnosis of SARD. Methods: ANA+ individuals who: 1) lacked clinical symptoms of SARD (ANA No Symptoms, ANS); 2) had a least one clinical symptom of SARD (Undifferentiated Connective Tissue Disease, UCTD); or 3) had a recently diagnosed steroid and immunosuppressive naïve SARD were recruited, and compared with ANA- healthy controls (HC). The levels of 30 cyto/chemokines were measured, 29 by Luminex and one (BAFF) by ELISA. Peripheral blood interferon (IFN)-induced and BAFF gene expression was ...
I lost my Mariel to Interstitial Lung Disease caused by Undifferentiated Connective Tissue Disease. Barely six weeks after we checked with a dermatologist to complain about some ordinary rashes and fever. ( We were even discharged earlier at another hospital for what they thought was merely a viral infection, after ruling out Dengue ). C3…
This multicenter study will attempt to determine the epidemiologic, clinical, serologic and immunogenetic factors associated with patients who develop scleroderma/systemic sclerosis after silicone prosthesis implantation or silicone injection. This will be accomplished by comparing these patients to groups of appropriately matched patients with idiopathic scleroderma/systemic sclerosis without silicone exposure, and appropriately matched volunteers who have received similar silicone implants or injections and have not developed symptoms, physical examination findings, or laboratory abnormalities associated with autoimmune/connective tissue diseases. Patient and physician questionnaires will be self-administered, and will collect data regarding: the number and types of implanted silicone devices or injections; the indications for and nature of the surgical procedures; peri- and post-operative complications; initial and subsequent clinical presentations; and therapy and clinical course of the ...
Non-specific interstitial PNA (NSIP) - basilar-predominant process, ground glass opacities and reticular pattern on imaging, 80% of patients will have fibrotic pattern as well, seen in patients with undifferentiated connective tissue disease, SLE, Sjogrens, Systemic sclerosis, and ...
Hello, I havent posted in a long time - my official diagnosis is undifferentiated connective tissue disease with signed of lupus and Sjögrens syndrome. My last rheumatology check up was almost a...
She has masters degrees in applied, clinical early signs of pregnancy in my dog community ssigns. i want to bookmark everything you ever write. Be sure your schedule is coordinated with other teachers in the school. But the real trouble do a force much larger than they are-one which they cant even pinpoint, and so have little chance to fight. Your babys size may make you feel uncomfortable. Then they were born and their parents wouldnt let you. Plan for some decompression time between conferences. A doctor can sgns you from this requirement. One question that single parents often have is how to make quality time for their children, despite their exhaustion. O quality of education. A recent Consumers Research magazine report on the risk to health from some fluorescent lamps suggested new probes by industry and the government. Your tips are super helpful, thank you. In case undifferentiated connective tissue disease and pregnancy are on the look-out for schools in Punjabi Bagh from the best ...
Background Pulmonary hypertension (PH) can develop in connective tissue disease associated interstitial lung disease (CTD-ILD), and contributes to increased morbidity and mortality. However, except...
Rodriguez et al were the first to report autoantibodies directed against the Golgi complex identified in the serum of a patient with Sjögrens syndrome (SS).1 Since then, several isolated reports have described the presence of anti-Golgi antibodies (AGAs) in several connective tissue diseases (CTDs).1-7 In addition, immunoblotting and immunoprecipitation studies have suggested that there are at least 14 different Golgi complex autoantigens, and their molecular masses range from 35 to 260 kDa.5 However, few reports describe the association between the clinical features of CTD and AGAs. In this letter we present a case of rheumatoid arthritis (RA) associated with AGAs and review several reported cases.. The patient was a woman born in 1939 who developed seropositive RA in 1990. She was admitted to our hospital in March 1998 because of high grade fever, cough, sore throat, chest pain, and severe arthralgia. Systemic laboratory examination disclosed no antinuclear antibody, anti-DNA antibody, or ...
To determine the clinical significance of anticentromere (ACA) and anti Scl-70 antibodies in an English population with connective tissue diseases, we examined the sera of 150 patients, including 40...
Background Interstitial pneumonia in connective tissue diseases (CTD-IP) featuring inflammation and fibrosis is usually a leading cause of death in CTD-IP individuals. by histology, circulation cytometry and molecular biology. Capital t cell subsets included in the procedure of CTD-IP had been described, while the regulatory features of MSCs separated from the bone tissue marrow of regular people (HBMSCs) on cytotoxic Capital t cells and CTD-UIP HLFs had been looked into in vitro. Outcomes Higher frequencies of cytotoxic Capital t cells had been noticed in the lung and peripheral bloodstream of CTD-IP individuals, followed with a decreased regulatory Capital t cell (Treg) level. CTD-UIP HLFs secreted proinflammatory cytokines in mixture with upregulation of -clean muscle mass actin (-SMA). The addition of HBMSCs in vitro improved Tregs SC-514 concomitant with decreased cytotoxic Capital t cells in an fresh cell model with prominent cytotoxic Capital t cells, and advertised Tregs growth in ...
WHO Group 1 PH (PAH, pulmonary arterial hypertension) is a progressive and chronic disease. There currently is no cure. In PAH, the arteries in the lungs become narrow, thickened or stiff, which causes high blood pressure in the lungs. The disease can present in several forms, one of which is PAH associated with connective tissue disease (CTD-PAH), such as scleroderma, CREST syndrome and lupus. Research has found that this particular form of PAH is difficult to treat and patients have worse outcomes compared to people with other types of PAH. Two groups of researchers looked at different approaches to treating CTD-PAH using PH-targeted medications.. Selexipag therapy. The European Respiratory Journal published the findings of one study on the use of selexipag (Uptravi®) in patients with CTD-PAH. (https://www.ncbi.nlm.nih.gov/pubmed/28818881) Sean Gaine, M.D. - National Pulmonary Hypertension Unit, Mater Misericordiae University Hospital in Dublin - led an international team of researchers to ...
Background: Connective tissue disease (CTD) is a group of inflammatory disorders of unknown aetiology. Patients with CID often report hypersensitivity to nickel. We examined the frequency of delayed type hypersensitivity (DTH) (Type IV allergy) to metals in patients with CTD. Methods: Thirty-eight patients; 9 with systemic lupus erythematosus (SLE), 16 with rheumatoid arthritis (RA), and 13 with Sjogrens syndrome (SS) and a control group of 43 healthy age- and sex-matched subjects were included in the study. A detailed metal exposure history was collected by questionnaire. Metal hypersensitivity was evaluated using the optimised lymphocyte transformation test LTT-MELISA (R) (Memory Lymphocyte Immuno Stimulation Assay). Results: In all subjects, the main source of metal exposure was dental metal restorations. The majority of patients (87%) had a positive lymphocyte reaction to at least one metal and 63% reacted to two or more metals tested. Within the control group, 43% of healthy subjects ...
This ACD course teaches, from a dermatological perspective, about the most commonly encountered Connective Tissue Disease including autoimmune disorders such as Lupus, Dermatomyositis and Scleroderma.
This article reviews the associations of occupational and environmental exposures relevant to connective tissue diseases, and in particular systemic sclerosis.
This article will inform you about lupus and connective tissue disease as well as other similar disorders that are interconnected with the disease.
Connective tissue diseases are generally rare with varying prevalence. Accurate diagnosis and specialist care are key to proper management.
Uveitis Caused by Connective Tissue Disease - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical Professional Version.
Get to know the muscle and connective tissue diseases and learn more about lipoma, fibroids and duchenne muscular dystrophy. Epidemiology and clinical presentation of soft tissue pathology ✓, treatment of primary systemic amyloidosis ✓, myoma and myosarcoma ✓. Read more here!
University of Minnesota Health physicians are available to help you with some of the most advanced treatments to relieve pain from connective tissue disease and improve your quality of life.
undifferentiated connective tissue disease answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad, Android, and Web.
Definition of mixed connective tissue diseases in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is mixed connective tissue diseases? Meaning of mixed connective tissue diseases as a legal term. What does mixed connective tissue diseases mean in law?
TY - JOUR. T1 - Secretory Diarrhea in Mixed Connective Tissue Disease. AU - Thiele, Dwain L. AU - Krejs, G. J.. N1 - Copyright: Copyright 2016 Elsevier B.V., All rights reserved.. PY - 1985/2. Y1 - 1985/2. N2 - Intractable diarrhea of 2 years duration was evaluated in a patient with mixed connective tissue disease and dilatation of the proximal small bowel. Stool analysis revealed secretory diarrhea. Intestinal perfusion studies showed that the jejunum was secreting water and electrolytes. Chloride and bicarbonate secretion against an electrical gradient suggested active anion secretion. Absorption in the ileum was normal. No evidence for bacterial colonization of the small bowel, protein‐losing enteropathy, or a hormonal cause of intestinal secretion could be found. This case report suggests that water and electrolyte secretion in dilated segments of small bowel may be another cause of diarrhea in cases of gastrointestinal involvement by systemic connective tissue disease.. AB - Intractable ...
Looking for online definition of connective tissue diseases in the Medical Dictionary? connective tissue diseases explanation free. What is connective tissue diseases? Meaning of connective tissue diseases medical term. What does connective tissue diseases mean?
TY - JOUR. T1 - Mixed connective tissue disease. AU - Hoffman, Robert W.. AU - Greidinger, Eric L.. PY - 2000. Y1 - 2000. N2 - A defining feature of mixed connective tissue disease (MCTD) is the presence of antibodies against the U1-ribonucleoprotein (RNP) complex, but other autoantibodies in MCTD have recently been described. Research has also further elucidated the immune responses directed against U1-RNP in humans and in murine models of disease. Hypotheses implicating modified self-antigens and/or infectious agents in the pathogenesis of MCTD have been advanced. Links between the immunologic and clinical phenomena in MCTD are emerging. Longitudinal study of patients with MCTD highlights the impact of pulmonary hypertension on disease outcome. (C) 2000 Lippincott Williams and Wilkins, Inc.. AB - A defining feature of mixed connective tissue disease (MCTD) is the presence of antibodies against the U1-ribonucleoprotein (RNP) complex, but other autoantibodies in MCTD have recently been ...
It is often several years before sufficient signs and symptoms appear to make the diagnosis of MCTD, relative to the more sequential clinical manifestations of SLE, scleroderma, and polymyositis, so often, in the initial phases, the diagnosis most appropriate for patients is undifferentiated connective tissue disease.[19] If the patient has edematous hands and/or swollen fingers in conjunction with elevated titers of antinuclear antibodies, an elevated titre of anti-U1 RNP antibody is a good predictor of progressing to MCTD.[20] The presence of this specific antibody is sine qua non for the diagnosis of MCTD,[19] although its isolated presence does not guarantee that a patient has MCTD or will develop it. If the dominant autoantibodies are antiDNAn, Sm, Scl70 or Ro, it is likely the patient will develop another connective disease distinct from MCTD. The clinical manifestations of MCTD appear correlated more intensely to the antibodies against protein A and 68 kD of the U1 RNP complex. The ...
People with mixed connective tissue disease (MCTD) have systemic lupus erythematosus, scleroderma, and polymyositis. Get information on mixed connective tissue disease (MCTD) symptoms, types, treatment, and prognosis.
Best Treatments for Mixed connective tissue disease in Pune : Find Best Doctors, Book Appointment, Call Now, Get Address & numbers of Best Treatments for Mixed connective tissue disease in Pune
Individuals with mixed connective tissue disease have symptoms that overlap with those of two or more connective tissue diseases. These diseases include systemic lupus erythematosus, polymyositis, scleroderma, and rheumatoid arthritis. (For more information on these disorders, see the Related Disorders section of this report.). A condition known as Raynauds phenomenon may precede the development of additional symptoms of MCTD. Raynauds phenomenon, which is seen also in scleroderma, is characterized by painfully cold fingers and toes with blue and/or white color changes caused by spasm of blood vessels in the hands and feet in response to cold or stress. It occurs in approximately 90 percent of individuals with MCTD.. Pain in multiple joints (polyarthralgia) or inflammation of joints (arthritis) also occurs in the majority of affected individuals. Lupus-like skin inflammation in sun-exposed areas and hair loss are common, as are skin scarring changes on the fingers and face like those seen in ...
is a systemic connective tissue disease characterized by the variable association of cardiovascular, musculoskeletal, ocular, and pulmonary symptoms.
TY - JOUR. T1 - Clinical significance of antibodies to a 68 kDa U1RNP polypeptide in connective tissue disease. AU - McHugh, N. AU - James, I. AU - Maddison, P. PY - 1990. Y1 - 1990. N2 - In a series of 163 patients with systemic lupus erythematosus (SLE) and/or systemic sclerosis and/or mixed connective tissue disease (MCTD), the presence of antibodies to a 68 kDa U1RNP associated polypeptide was more predictive for SLE (88%) than for MCTD (38-68%) using 3 different sets of proposed criteria for the latter condition. In all but one case studied serially the immunoblotting profile remained constant. In SLE recognition of the 68 kDa polypeptide identified a subset with increased vasoreactivity with Raynauds phenomenon (96%, p less than 0.001) and swollen fingers (68%, p less than 0.001) whereas recognition of a 47 kDa La (SSB) polypeptide was associated with photosensitivity (72%, p less than 0.02), less renal involvement (p less than 0.05) and an older age of disease onset (46.6 years +/- 18.3 ...
This dissertation describes the results of a population-based case-control study of risk factors for five connective tissue diseases: systemic lupus erythematosus, Sjogrens syndrome, systemic sclerosis/CREST syndrome, polymyositis/dermatomyositis and mixed connective tissue disease.Cases were female residents of King County, Washington who were diagnosed by a rheumatologist between January 1, 1983 and December 31, 1991 as having a disease of interest. Two control groups were used. The new control group was identified by random digit telephone dialing and was frequency matched to the case group on age at diagnosis and calendar year of diagnosis. Mailed questionnaires were used for concurrent data collection on the cases and on the new control group, with a telephone administered questionnaire for non-respondents. The pre-existing control group had been used for three other epidemiologic studies, and was identified and had in-person interviews before 1992, when mass media attention to the ...
This is a photo of a finger ulcer caused by secondary Raynauds phenomenon in a patient with mixed connective tissue disease (MCTD). The MCTD developed after thyroidectomy.
Test for mixed connective tissue disease, an autoimmune disease often referred to as overlap syndrome. RNP antibodies found in 95-100% MCTD patients
Mixed Connective Tissue Disease (MCTD) - Learn about the causes, symptoms, diagnosis & treatment from the Merck Manuals - Medical Consumer Version.
Statement of Intent. MCTDfoundation.org is a non-profit, online gathering place, for those living with the Mixed Connective Tissue Disease (MCTD), their friends, families, support systems and medical providers.. We strive to present the most current information available on the overlap autoimmune diseases that comprise MCTD, as well as available treatment options.. We sell MCTD awareness merchandise as a fundraising mechanism to ensure the future of the site, as well as providing educational materials.. We provide forums for those afflicted, as well as blog formatted personal stories of those who care to share their personal journey with the disease. Only when we can share symptoms and histories can we start to identify commonalities. As appropriate, photographs of symptoms will also be filed.. An important aspect to be covered on the website is the impact of the Autoimmune Protocol Paleo diet, one of the clean eating plans that has helped modify the disease process for many patients.. Our ...
Tiddens HA, van der Net JJ, de Graeff-Meeder ER, Fiselier TJ, de Rooij DJ, van Luijk WH, Herzberger R, van Suijlekom LW, van Venrooij WJ, Zegers BJ, et al. Juvenile-onset mixed connective tissue disease: longitudinal follow-up. J Pediatr. 1993 Feb;122(2):191-7. [Medline]. ...
Still, they mean well, dont they? So I should accept their advice with grace and just move on. Shouldnt I?. Maybe yes, maybe no. How will they learn what inflammatory arthritis, rheumatoid arthritis, mixed connective tissue disease, lupus, spondylitis…how will they ever know what these diseases really are and how they affect my life, if I dont educate them?. But educating gets tiring. Its hard work raising awareness, one person at a time. So sometimes I just have a giggle at the weird and wonderful (and conflicting) advice I receive regularly. Sometimes totally opposing advice, from the same person within a few days.. Heres a sample…. You just need to push through the pain! You need to develop a higher pain tolerance!. You should rest more. The pain is telling you to rest your body. If you rest more, youll be fine.. Try eating this. Its an anti-inflammatory super food. (Regardless of the fact that I eat it all the time). Dont EVER eat this! Not ever. Its the cause of all your ...
The paper outlines the experience with minimally invasive surgical technologies for esophageal injury in the presence of systemic connective tissue disease. The clinical example clearly demonstrates the importance of timely diagnosis of esophageal stricture in CREST syndrome and suggests that it is necessary to treat these difficult-to-treat patients at large multiprofile hospitals ...
Mixed connective tissue disease is a rare autoimmune disorder featuring signs and symptoms of three different disorders: lupus, scleroderma and polymyositis.
Patients with juvenile mixed connective tissue disease had impaired left and right ventricular function compared with matched controls after a median of 15 years disease duration.
I have a mixed connective tissue disease that does not currently have a name. I was tested for marfans syndrome and it was negitative, but did show a gene mutation. It just wasnt a recognized one. My immediate family was tested at John Hopkins for ehlers danlos syndrome but it was negitative but also showed a gene malformation. They sent my family home with tons of information on eds because even though we dont have that exact kind it is very similar to it. Anybody else have this problem? My medical problems are extensive and it seems its hit or miss in my family as far as severity!! Any help would be appreciated. Thank you ...
Mixed connective tissue disease has signs and symptoms of multiple disorders, making it difficult to diagnose. Theres no cure, but medications can help.
There are a few tips, however, that can make a huge difference during a pregnancy. Staying healthy and fit during pregnancy should be a womans prime concern. Hi Bettany, wish you luck and also remember to consult your doctor instead of relying on self-diagnoses, Take care. I had to have extra appointments at the hospital to have my airways measured incase I need an emergency general aneasthetic. Turns out, the Alaska Business Journal is in a couple of electronic databases that most libraries should have. Nothing against doctors, Western Medicine, or advice from fertility experts, but theres one thing they always miss-something that I call the missing link. Thats the only way to know for sure. THURSDAY (Jupiter): you are polite, considerate, and soft-spoken. The female must not indulge in strenuous exercise. Your doctor may want to confirm the pregnancy with an in office test but mixed connective tissue disease and pregnancy are basically the same as the home tests. The second phase is called ...
Mixed connective tissue disease patients can claim disability benefits as it is considered as a disability. Read on to know more.
Overview of Mixed connective tissue disease as a medical condition including introduction, prevalence, prognosis, profile, symptoms, diagnosis, misdiagnosis, and treatment
Learn about Mixed connective tissue disease. What are the symptoms, the causes and how to treat this condition? What can we do to cope and prevent it...
Hedayati H, Kloetzli N. Mixed connective tissue disease: report of a case with fatal outcome. J Am Osteopath Assoc 1987;87(9):622. doi: https://doi.org/10.7556/jaoa.1987.87.9.622.. Download citation file:. ...
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Ceftriaxone therapy of chronic inflammatory arthritis. A double-blind placebo controlled trial. Arch Intern Med. 1990 Aug;150(8):1677-82.. In a placebo-controlled, double-blind study of 60 patients with inflammatory arthritis - rheumatoid arthritis (RA), psoriatic arthritis (PsA), vasculitis, and undifferentiated connective tissue disease (UCTD) - who were positive for Lyme disease (borrelia burgdorferi), patients were randomized to be in one of two study arms to either receive an inactive placebo or the antibiotic, ceftriaxone, 2 grams/day, intravenously for 2 weeks. Nearly half of the antibiotic group (19/40 patients) experienced improvement as compared with the placebo group (2/20 patients), who were later able to elect to receive ceftriaxone therapy. Of 58 patients who were treated with IV ceftriaxone, 27 were notably improved at follow-up, 13-24 months later, and responses were seen in all forms of arthritis (RA 5/12, PsA 5/8, vasculitis 3/5, and UCTD 14/33). Of these 27 patients, 16 ...
TY - JOUR. T1 - Peripheral sensorimotor and autonomic neuropathy associated with systemic lupus erythematosus. T2 - Clinical, pathological and immunological features. AU - Mccombe, P. A.. AU - Mcleod, J. G.. AU - Pollard, J. D.. AU - Guo, Y. P.. AU - Ingall, T. J.. PY - 1987/4. Y1 - 1987/4. N2 - The clinical features and pathological findings in the sural nerves are described of 7 patients with peripheral neuropathy; in 4 cases the criteria for diagnosis of systemic lupus erythematosus (SLE) were satisfied and in 3 other cases there was serological evidence of an undifferentiated connective tissue disease, most probably SLE. The peripheral neuropathy was of a chronic sensorimotor type with predominantly sensory features and gradual onset. In 2 cases the presentation was asymmetric. One patient had autonomic dysfunction. The pathological findings in the biopsied sural nerves were those of axonal degeneration and vasculitis. In 6 nerves there was increased expression of Class II (Ia) antigen ...
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Background and objectives: The overlap between antineutrophil cytoplasmic antibody (ANCA) associated glomerulonephritis (ANCA-GN) and connective tissue diseases (CTD) has been reported mainly as case series in the literature. Frequency of this association, as well as presentation and outcomes are unknown. Materials and Methods: Patients from the Maine-Anjou ANCA-associated vasculitides (AAV) registry with ANCA-GN diagnosed between 01/01/2000 and 01/01/2018, ANCA positivity, and at least six months of follow-up, were included. Results: 106 out of 142 patients fulfilled the inclusion criteria and were analyzed. CTD was present at ANCA-GN diagnosis in 16 (15.1%) patients. The most common CTD were rheumatoid arthritis, Sjogren syndrome and systemic sclerosis. Compared to the control group, females were more represented in the CTD group (75%, p = 0.001). Renal presentation was comparable between groups, including the pathological analysis of renal biopsies. Patients of CTD group presented a higher rate of
NIH Rare Diseases : 50 arterial tortuosity syndrome is a disorder that affects connective tissue (a tissue that provides strength and flexibility to structures throughout the body). it is characterized by blood vessel abnormalities, particularly abnormal twists and turns (tortuosity) of the blood vessels that carry blood from the heart to the rest of the body (the arteries). other blood vessel abnormalities that may occur in this disorder include constriction (stenosis) and abnormal bulging (aneurysm) of vessels, as well as small clusters of enlarged blood vessels just under the skin (telangiectasia). other features include: joints that are either loose and very flexible (hypermobile) or that have deformities limiting movement (contractures) soft and stretchable skin long, slender fingers and toes (arachnodactyly) curvature of the spine (scoliosis) sunken chest (pectus excavatum) or protruding chest (pectus carinatum) protrusion of organs through gaps in muscles (hernias) elongation of the ...
Connective Tissue Disorder and Disability: undifferentiated or mixed connective tissue disease may qualify for disability if you are unable to work
Osteogenesis imperfecta (OI) is a systemic connective tissue disorder most often caused by mutations in collagen type 1 related genes. Patients with OI suffer from multiple fractures and various...
Hereditary progressive arthro-ophthalmopathy definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
A diagnosis can be difficult to make because the three conditions (SLE, scleroderma, and polymyositis) that can be seen in MCTD usually occur one after the other over a long period of time, rather than at the same time. It may take several years to make an accurate diagnosis of MCTD.. There are four features that point to MCTD rather than another connective tissue disorder:. ...
In general, use of ACE inhibitors significantly reduced the development of proteinuria and/or biopsy-proven lupus nephritis and was associated with a decreased risk of disease activity [86]. Concomitant use of antimalarial drugs (chloroquine and hydroxychloroquine) at diagnosis of lupus nephritis reduced the risk of progression to end-stage renal failure and frequency of hypertension [87].. Specific treatment follows the class of lupus nephritis, which is defined by the revised ISN criteria. Class I and class II require no therapy directed at the kidney in consequence of good long-term renal outcome [88]. In contrast, high-dose steroid therapy rapidly resolved nephrotic syndrome in a majority of SLE patients with minimal change disease either in the absence or with underlying class II lupus nephritis based on renal biopsy findings [82, 83]. Immunosuppressive treatment is required in the management of class III (focal), class IV (diffuse) and class V (membranous nephropathy) lupus nephritis and ...
Heritable connective tissue diseases comprise a heterogeneous group of multisystemic disorders that are characterized by significant morbidity and mortality. These disorders do not merely result from defects in the amount or structure of one of the components of the extracellular matrix, as the extracellular matrix also serves other functions, including sequestration of cytokines, such as transforming growth factor beta (TGFβ). Indeed, disturbed TGFβ signaling was demonstrated in several heritable connective tissue diseases, including syndromic forms such as Marfan or Loeys-Dietz syndrome and non-syndromic presentations of thoracic aortic aneurysm/dissection. Because of these findings, new therapeutic targets have been unveiled, leading to the initiation of large clinical trials with angiotensin II type 1 receptor antagonists that also have an inhibiting effect on TGFβ signaling. Here, we present an overview of the clinical characteristics, the molecular findings, and the therapeutic ...
Clinical trial for SYSTEMIC LUPUS ERYTHEMATOSUS | Connective Tissue Diseases | Autoimmune disease | Dermatomyositis (Connective Tissue Disease) | Lupus Nephritis | CONNECTIVE TISSUE DISEASE | Glomerulonephritis , A Study of KZR-616 in Patients With SLE With and Without Lupus Nephritis
Results. In the group of patients with Raynauds phenomenon mean serum concentration of ET-1, TNF-α, PF-4, and vWF was significantly greater than in the healthy group. In contrast, serum IL-6 and IL-6sR concentrations did not differ significantly between the diseased and healthy groups. In a subgroup of Raynauds phenomenon patients showing particularly high concentration of serum ET-1 (twice as much as mean control concentration), the increase in IL-6, IL-6sR, vWF and c-ANCA concentration exhibited statistical significance in comparison with patients with lower serum ET-1 concentration. The vWF concentration exhibited positive correlation with time interval between the occurrence of clinical symptoms and serum ANA antibodies concentration. The increase in ET-1 synthesis in Raynauds phenomenon patients is dependent on the increase in IL-6 level and c-ANCA antibodies level ...
Reversible vasospasm of the extremities occurs as an isolated symptom in the absence of underlying disease (primary Raynaud phenomenon) or in association with other disorders (secondary Raynaud phenomenon). It has been reported that Raynaud phenomenon is associated with connective tissue diseases, but the frequency and types of diseases that eventually develop are not well established. Spencer-Green conducted a systematic literature search to assess the rates and predictors of transition to secondary disease after a primary diagnosis of Raynaud phenomenon.. A total of 639 patients with primary Raynaud phenomenon were identified from 10 studies. The average length of study follow-up was four years. The average duration of Raynaud phenomenon in the study subjects was 12.3 years. During follow-up, 12.6 percent (81 patients) developed a secondary disorder. Eighty of these cases were connective tissue diseases. Two thirds of the cases of connective tissue disease were attributed to systemic ...
The fact is that biology doesnt conform well to hard and fast rules. The immune system is particularly difficult this way; I used to tell my undergraduate immunology students that every rule they learned in class would have an exception somewhere. Since the immune system itself doesnt follow strict rules, it should come as no great surprise that autoimmune diseases dont either. I regard autoimmune diseases as being points on a continuum, rather than existing as discrete entities. These diseases all share in common the fact that the immune system has lost the ability to tell whether various tissues in the body are part of the body or whether they are invading germs. Specific autoimmune diseases are diagnosed depending on which parts of the body are being attacked, and by which parts of the immune system are doing the attacking ...
For a long time before diagnosis I began to lose strength, I had mentioned in passing at a number of doctors appointments but it was never the main reason for my visit. As I was living quite a sedentary lifestyle it was attributed to this. Once I changed jobs to a more computer based role I started to notice pain in my wrist and fingers. I visited the doctors and they suggested it was a form of repetitive strain injury, tendonitis. At the end of 2014 I was lucky enough to go on a 3 week holiday where I still experienced the pain in my joints and fatigue which could no longer be attributed to work. When I got back home I visited the doctor who booked me in for a blood test and referred me to a rheumatologist. The first one I saw was absolutely useless but the rheumatology nurse was still concerned with my results and escalated it to the consultants meeting. Following the meeting I was called back to the hospital by my current consultant who booked me in for a load of tests (blood work, CT scan, ...
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M: Diseases of the musculoskeletal system and connective tissue[edit]. *(M25.1) Fistula of joint ... Diseases Inflammatory bowel disease, more often in the form of Crohn's disease than ulcerative colitis,[6] is the leading cause ... For example, surgical treatment of fistulae in Crohn's disease can be effective, but if the Crohn's disease itself is not ... N: Diseases of the urogenital system[edit]. *(N32.1) Vesicointestinal fistula. *(N36.0) Urethral fistula *Innora:between the ...
Connective-tissue diseases. *Inflammatory conditions. *Nasal fractures. *Naso-orbito-ethmoidal fractures - damages to the nose ... collagenous connective tissue that covers, invests, and forms the terminations of the muscles. ... using intranasal tissues to correct defects of the mucosa; cartilage battens to brace against tissue contraction and depression ... the sesamoid cartilages are adjacent to the upper lateral-cartilages in the fibroareolar connective tissue. ...
In addition to SLE, these antibodies are highly associated with mixed connective tissue disease. Anti-nRNP antibodies recognise ... A significant number of patients are diagnosed as systemic lupus erythematosus or undifferentiated connective tissue disease ... mixed connective tissue disease,[5] polymyositis, dermatomyositis, autoimmune hepatitis[6] and drug induced lupus.[7] ... "Mixed connective tissue disease". Lupus. 15 (3): 132-7. doi:10.1191/0961203306lu2283rr. PMID 16634365. S2CID 25736411.. ...
Trozak D, Gould W (1984). "Cocaine abuse and connective tissue disease". J Am Acad Dermatol. 10 (3): 525. doi:10.1016/S0190- ... "Neurology of the vasculitides and connective tissue diseases". J. Neurol. Neurosurg. Psychiatry. 65 (1): 10-22. doi:10.1136/ ... and pathological restricting of lung tissue.[16] Cocaine may also increase risk for autoimmune disease[17][18][19] and damage ... Muriel P, Arauz J (2010). "Coffee and liver diseases". Fitoterapia. 81 (5): 297-305. doi:10.1016/j.fitote.2009.10.003. PMID ...
Associated conditions:Connective tissue disease, HIV infection, Portal hypertension, Congenital heart diseases, Schistosomiasis ... Associated conditions:connective tissue disease, HIV infection. WHO Group I" - Persistent pulmonary hypertension of the newborn ... Hematologic diseases: chronic hemolytic anemia (including sickle cell disease). *Systemic diseases: sarcoidosis, pulmonary ... Metabolic disorders: glycogen storage disease, Gaucher disease, thyroid diseases. *Others: pulmonary tumoral thrombotic ...
Diseases of the skin and subcutaneous tissue XIII M00-M99 Diseases of the musculoskeletal system and connective tissue ... G00-G99 - Diseases of the nervous system[edit]. (G00-G09) Inflammatory diseases of the central nervous system[edit]. *(G00) ... G30) Alzheimer's disease. *(G31) Other degenerative diseases of nervous system, not elsewhere classified *(G31.0) ... G94) Other disorders of brain in diseases classified elsewhere. *(G95) Other diseases of spinal cord *(G95.0) Syringomyelia and ...
Mixed connective tissue disease (other than systemic sclerosis). *Crohn's disease. *Dermatomyositis. *Idiopathic ... has been shown to prolong lives ... a progressive and fatal disease that has no drug treatment available in the US. ... FDA-approved deflazacort treats rare type of disease affecting boys. CS1 maint: Uses authors parameter (link) ... "progressive and fatal disease" that affects boys.[7] Although deflazacort was approved by the FDA for use in treatment of ...
Halper J (2014). "Proteoglycans and diseases of soft tissues". Progress in Heritable Soft Connective Tissue Diseases. Adv. Exp ... and the non-disease-associated form bind differentially to C-reactive protein, fibromodulin, DNA, and necrotic cells". The ... Molecular Basis of Disease. 1406 (2): 203-13. doi:10.1016/S0925-4439(98)00005-2. PMID 9573366. Font B, Eichenberger D, ... so non-glycated forms of fibromodulin can accumulate in tissues such as cartilage. Fibromodulin is found in the epidermis of ...
Progress in Heritable Soft Connective Tissue Diseases. Advances in Experimental Medicine and Biology. 802. pp. 201-30. doi: ... In menopausal endometrial tissue, the level of lumican expression decreases and is also low in pathological compared to normal ... Lumican is present in the extracellular matrix of uteral tissues in fertile women. There is an increase of lumican during the ... Lum knockout mice also have abnormal collagen in their heart tissue, with fewer and thicker fibrils. Mice deficient in both ...
AD is more common in those with a history of high blood pressure, a number of connective tissue diseases that affect blood ... Progress in Heritable Soft Connective Tissue Diseases. Adv. Exp. Med. Biol. Advances in Experimental Medicine and Biology. 802 ... Repair may be recommended when greater than 4.5 cm (1.8 in) in size if the person has one of the several connective-tissue ... the media contains connective and muscle tissue, and the vessel is protected on the outside by the adventitia, comprising ...
They may be associated with connective tissue diseases. The sign is named after the dermatologist Irwin M. Braverman. Patel, ... Skin signs of systemic disease. New York: Elsevier; 2008. ISBN 9780721637457 Patel LM, Lambert PJ, Gagna CE, Maghari A, Lambert ... Laju M.; Lambert, Phelps J.; Gagna, Claude E.; Maghari, Amin; Lambert, W. Clark (2011). "Cutaneous signs of systemic disease". ... WC (2011). "Cutaneous signs of systemic disease". Clin. Dermatol. 29 (5): 511-22. doi:10.1016/j.clindermatol.2011.01.019. PMID ...
... may also greatly increase the risk of developing rare autoimmune or connective tissue diseases such as lupus, ... Trozak DJ, Gould WM (March 1984). "Cocaine abuse and connective tissue disease". Journal of the American Academy of Dermatology ... Moore PM, Richardson B (July 1998). "Neurology of the vasculitides and connective tissue diseases". Journal of Neurology, ... It can also cause a wide array of kidney diseases and kidney failure. Cocaine use leads to an increased risk of hemorrhagic and ...
Trozak D, Gould W (1984). "Cocaine abuse and connective tissue disease". J Am Acad Dermatol. 10 (3): 525. doi:10.1016/S0190- ... Moore PM, Richardson B (1998). "Neurology of the vasculitides and connective tissue diseases". J. Neurol. Neurosurg. Psychiatry ... and pathological restricting of lung tissue. Cocaine may also increase risk for autoimmune disease and damage nasal cartilage. ... Moderate coffee consumption may decrease the risk of cardiovascular disease, and it may somewhat reduce the risk of type 2 ...
"Mixed Connective Tissue Disease (MCTD) , Cleveland Clinic". my.clevelandclinic.org. Retrieved 2016-11-07. Ruigrok, Rob WH; ... Anti-RNP antibodies are autoantibodies associated with mixed connective tissue disease and are also detected in nearly 40% of ... "RNA-binding proteins in human genetic disease". Trends in Genetics. 24 (8): 416-425. doi:10.1016/j.tig.2008.05.004. ISSN 0168- ...
Autoimmune Mixed connective tissue disease Maddison PJ (December 1991). "Overlap syndromes and mixed connective tissue disease ... Examples of overlap syndromes in rheumatology include mixed connective tissue disease and scleromyositis. Diagnosis depends on ... "Overlap connective tissue disease syndromes". Autoimmunity Reviews. 12 (3): 363-73. doi:10.1016/j.autrev.2012.06.004. PMID ... Examples of overlap syndromes can be found in many medical specialties such as overlapping connective tissue disorders in ...
Hohenstein, B.; Bornstein, S.R.; Aringer, M. (2013). "Immunoadsorption for connective tissue disease". Atherosclerosis ... Stummvoll, G; Aringer, M; Handisurya, A; Derfler, K (September 2017). "Immunoadsorption in Autoimmune Diseases Affecting the ...
Group of autoimmune diseases resulting in abnormal growth of connective tissue. This article is about the disease. For the ... Mixed connective tissue disease, systemic lupus erythematosus, polymyositis, dermatomyositis[1]. Treatment. Supportive care[1] ... "The Prevalence of Atherosclerosis in Those with Inflammatory Connective Tissue Disease by Race, Age, and Traditional Risk ... Eosinophilic fasciitis affects the connective tissue surrounding skeletal muscles, bones, blood vessels, and nerves in the arms ...
Common causes include autoimmune diseases and connective tissue diseases. Diagnosis of DAH is often given following observation ... Park, Moo Suk (April 2013). "Diffuse Alveolar Hemorrhage". Tuberculosis and Respiratory Diseases. 74 (4): 151-62. doi:10.4046/ ...
"Connective Tissue Diseases". Rheumatology. London: Manson Publishing. p. 117. ISBN 978-1-84076-173-3. .. ... Secondary Raynaud's can occur due to a connective-tissue disorder, such as scleroderma or lupus, injuries to the hands, ... if they occur by themselves and not in association with other diseases. Some refer to primary Raynaud's disease as "being ... "Raynaud's disease Treatments and drugs - Mayo Clinic". www.mayoclinic.org. Archived from the original on 12 December 2015. ...
Neurological manifestations of connective tissue disease. Neurol Clinics 2002;20:151-178. "RR&D Brain Rehabilitation Research ... and neurological manifestations of vasculitis and connective tissue disease. He has been the medical director of two VA Office ...
"Silicone Breast Implants in Relation to Connective Tissue Diseases and Immunologic Dysfunction". Archived from the original on ... "Coronary Heart Disease". Weitz & Luxenberg P.C. Archived from the original on May 30, 2013. Retrieved March 20, 2013.. ... Cardiovascular disease associated with COX-2 inhibitors (i.e. Vioxx)[15]. *Deafness and kidney failure associated with ... "Centers for Disease Control and Prevention (CDC). 2018-07-12. Archived from the original on March 17, 2017. Retrieved March 20, ...
Pleural effusions may occur with cancer, sarcoid, connective tissue diseases and lymphangioleiomyomatosis. The presence of a ... peripheral (e.g., cryptogenic fibrosing alveolitis, connective tissue disease, chronic eosinophilic pneumonia, bronchiolitis ... lower (e.g., cryptogenic fibrosing alveolitis, connective tissue disease, asbestosis, drug reactions) ... Disease mimics[edit]. Disease mimics are visual artifacts, normal anatomic structures or harmless variants that may simulate ...
... hematologic and neoplastic diseases such as leukemia or bony tumors; and other connective tissue diseases (such as Systemic ... Rarely, skeletal dysplasias or metabolic diseases, such as Farber disease and forms of Mucopolysaccharidosis, may also mimic ... The disease appears to be more common in girls, and is most common in Caucasians. The cause of JIA, as the word "idiopathic" ... Patients with Farber disease typically have subcutaneous nodules and a hoarse or weak voice due to growth of nodules on the ...
Connective tissue components of Peyronie's disease plaque. Abstract 748. Journal of Urology 163:169, 2000 7. Michael Shaw, Lev ... Peyronie's Disease and its Medical Management in Male Infertility and Sexual Dysfunction. Wayne J.G Hellstrom editor. Springer- ...
This article about a disease of musculoskeletal and connective tissue is a stub. You can help Wikipedia by expanding it. *v ... Platybasia is a spinal disease of a malformed relationship between the occipital bone and cervical spine. It may be caused by ... Paget's disease. Platybasia is also a feature of Gorlin-Goltz syndrome, commonly known as basal cell nevus syndrome. ...
This article about a disease of musculoskeletal and connective tissue is a stub. You can help Wikipedia by expanding it.. *v ... A disc protrusion is a disease condition which can occur in some vertebrates, including humans, in which the outermost layers ...
Some systemic diseases, such as connective tissue disease, can cause MPS. Poor posture and emotional disturbance might also ... Myofascial pain is pain in muscles or fascia (a type of connective tissue that surrounds muscles). It can occur in distinct, ... connective tissue) constrictions. It can appear in any body part. Symptoms of a myofascial trigger points include: focal point ...
Pan Y, Wen X, Hao D, Wang Y, Wang L, He G, Jiang X (February 2020). "The role of IL-37 in skin and connective tissue diseases ... IL-37a,b,c are being expressed in a variety of tissues - thymus, lung, colon, uterus, bone marrow. It is produced by immune ... Wang L, Quan Y, Yue Y, Heng X, Che F (April 2018). "Interleukin-37: A crucial cytokine with multiple roles in disease and ... Some IL-37 isoforms are tissue specific: IL-37a - brain IL-37b - kidney, bone marrow, blood, skin, respiratory and urogenital ...
Tymms KE, Webb J (December 1985). "Dermatopolymyositis and other connective tissue diseases: a review of 105 cases". J. ... It is a rare disease. Chraibi S, Ibnabdeljalil H, Habbal R, Bennis A, Tahiri A, Chraibi N (November 1998). "Pericardial ...
Connective tissue cells. Hidden categories: *All articles with unsourced statements. *Articles with unsourced statements from ... Role in disease[edit]. Plasmacytoma, multiple myeloma, Waldenström macroglobulinemia and plasma cell leukemia are malignant ...
... skin discoloration and connective tissue damage from the accumulation of homogentisic acid).[35] ... This article is about a skin disease common during adolescence. For other acneiform skin diseases, see Acne (disambiguation). ... Disease Primers. 1: 15033. doi:10.1038/nrdp.2015.33. PMID 27227877.. *^ a b "Frequently Asked Questions: Acne" (PDF). U.S. ... Acne, also known as acne vulgaris, is a long-term skin disease that occurs when dead skin cells and oil from the skin clog hair ...
Connective tissue disease. *Drugs-aspirin, fexofenadine, warfarin, clopidogrel, prasugrel, isotretinoin, desmopressin and ... U.S. Centers for Disease Control Published 2001-05-11.. *^ a b c Wackym,, James B. Snow,... P. Ashley (2009). Ballenger's ... Chronic liver disease-cirrhosis causes deficiency of factor II, VII, IX,& X ... Hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome), a rare disease that runs in families ...
The skin consists of a thin outer epidermis with mucous cells and sensory cells, and a connective tissue dermis consisting ... Coccidians in the genus Aggregata living in the gut cause severe disease to the host. Octopuses have an innate immune system, ... Extensive connective tissue lattices support the respiratory muscles and allow them to expand the respiratory chamber.[37] The ... The diseases and parasites that affect octopuses have been little studied, but cephalopods are known to be the intermediate or ...
... before any genetic or morphological criteria were put in place for bone marrow or connective tissues. Osteoprogenitor cells can ... The results of this research was used as a model for Kashin-Beck disease. Kashin-Beck is a result of combinatorial ... These cellular units will then develop into skeletal and other tissues, such as cartilage, tendon, ligament and muscle tissue. ... The disease has symptoms similar to those resulting from Trsp gene knockout.[12] ...
Connective tissue growth factor (CTGF). *Ephrins (A1, A2, A3, A4, A5, B1, B2, B3) ... Interstitial lung disease. Mechanism of action[edit]. Like lapatinib and neratinib, afatinib is a protein kinase inhibitor that ...
Mixed connective tissue disease - a disease of the autoimmune system, also undifferentiated connective tissue disease. ... and special connective tissue.[5][6] Connective tissue proper consists of loose connective tissue and dense connective tissue ( ... Connective tissue (CT) is one of the four basic types of animal tissue, along with epithelial tissue, muscle tissue, and ... Special connective tissue consists of reticular connective tissue, adipose tissue, cartilage, bone, and blood.[8] Other kinds ...
Human brains are surrounded by a system of connective tissue membranes called meninges that separate the brain from the skull. ... Hourigan CS (2006). "The molecular basis of coeliac disease". Clin Exp Med (Review). 6 (2): 53-59. doi:10.1007/s10238-006-0095- ... in the sense that the neoplasm invades the space occupied by adjacent tissue, thereby pushing the other tissue aside and ... they will expand spatially and intrude into the space occupied by other brain tissue and compress those brain tissues); however ...
... which breaks down the connective tissue fiber elastin. Like all serine protease inhibitors, A1AT has a characteristic secondary ... The results of this program were first documented in the Effects of a Disease Management Program in Individuals with Alpha-1 ... As a type of enzyme inhibitor, it protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has ... Axelsson and Laurell first investigated the possibility of allelic variants of A1AT leading to disease in 1965. Alpha 1- ...
... a major constituent of extracellular microfibrils which form connective tissues.[36] Over 1,000 different mutations in FBN1 ... A common example of pleiotropy is the human disease phenylketonuria (PKU). This disease causes mental retardation and reduced ... "Complications and Treatments , Sickle Cell Disease". CDC. Retrieved 2016-11-11.. *^ a b c d "Marfan Syndrome". National ... "sickle cell disease". Genetics Home Reference. Retrieved 2016-11-11.. *^ MD, Kenneth R. Bridges. "How Does Sickle Cell Cause ...
... via connective tissue) to the rest of the viscera. By using a series of special muscles (roughly equivalent to a diaphragm), ... Paterson, Sue (December 17, 2007). Skin Diseases of Exotic Pets. Blackwell Science, Ltd. pp. 74-79. ISBN 9780470752432. .. ... Hellebuyck, Tom; Pasmans, Frank; Haesbrouck, Freddy; Martel, An (July 2012). "Dermatological Diseases in Lizards". The ... Morphological and cellular aspects of tail and limb regeneration in lizards a model system with implications for tissue ...
... or other connective or supportive tissue. Low-grade refers to cancerous and precancerous growths with cells that look nearly ... Diseases treated[edit]. *Thymoma and Thymic carcinoma: These tumors which arise from the thymus gland in the upper part of the ... The goal of surgical cytoreduction is to remove all gross disease including tumors that are in resectable areas of the lung or ... There are other intra-abdominal malignancies that may cross the diaphragm and cause disease in the chest that could be ...
... teeth and connective tissues - Aids the production of collagen which is the foundational matrix of bones, teeth, tendons, ... Maintains mucous cell tissues to ensure a secure barrier against harmful bacteria's and disease (Deen & Hark, 2007) Helps ... connective tissue and cartilage. Vitamin A ensures sufficient collagen is produced to build strong healthy bones and other ... Vitamin A assists in the maintenance and promotion of healthy growth of skin and tissues cells. Healthy growth of tissue cells ...
... connective tissue disease), ହାଇପୋଥାଇରଏଡିଜ୍ମ, ଆଓର୍ଟିକ ରପଚର (aortic rupture) ଓ ହୃତ୍‌ପିଣ୍ଡ ଅପରେଶନ (cardiac surgery) ପରେ ଏହି ରୋଗ ...
It also makes blood vessels more permeable so neutrophils and clotting proteins can get into connective tissue more easily. ... It rises in response to allergies, parasitic infections, collagen diseases, and disease of the spleen and central nervous ... Monocytes migrate from the bloodstream to other tissues and differentiate into tissue resident macrophages, Kupffer cells in ... Chronic inflammation - especially juvenile rheumatoid arthritis, rheumatoid arthritis, Still's disease, Crohn's disease, ...
The destruction of the connective tissue of the lungs leads to emphysema, which then contributes to the poor airflow, and ... Chronic obstructive pulmonary disease. Other names. Chronic obstructive lung disease (COLD), chronic obstructive airway disease ... Most cases of COPD are a mixture of both diseases.. *^ "Chronic obstructive pulmonary disease (COPD)". WHO. Retrieved 5 June ... Wikimedia Commons has media related to Chronic obstructive pulmonary disease.. *Chronic obstructive pulmonary disease at Curlie ...
The biochemistry of Hunter syndrome is related to a problem in a part of the connective tissue of the body known as the ... Hunter syndrome is one of several related lysosomal storage diseases called the MPS diseases. In Hunter syndrome, GAGs build up ... the effects of even mild disease are quite serious. Between the two main forms of disease, and even within them, two of the ... In Gangtok, the 8-year-old son of the editor of 'Voice of Sikkim' also suffers from the disease. A study in the United Kingdom ...
Connective tissue diseases. *Syndromes. *Drug safety. *Adulteration. Hidden categories: *All articles with dead external links ... "Rare Disease Database: Eosinophilia-Myalgia Syndrome". National Organization for Rare Disorders. NORD. Archived from the ... Most patients recover fully, remain stable, or show slow recovery, but the disease is fatal in up to 5% of patients. ... The first case of eosinophilia-myalgia syndrome was reported to the Centers for Disease Control and Prevention (CDC) in ...
Diseases of the skin and subcutaneous tissue XIII M00-M99 Diseases of the musculoskeletal system and connective tissue ... F02) Dementia in other diseases classified elsewhere *(F02.0) Dementia in Pick's disease ... F62) Enduring personality changes, not attributable to brain damage and disease. *(F63) Habit and impulse disorders *(F63.0) ... F06) Other mental disorders due to brain damage and dysfunction and to physical disease *(F06.0) Organic hallucinosis ...
Alzheimer's disease[edit]. Post mortem analysis has shown lowered levels of BDNF in the brain tissues of people with ... Connective tissue growth factor (CTGF). *Ephrins (A1, A2, A3, A4, A5, B1, B2, B3) ... Alzheimer's disease,[71] Huntington's disease,[72] Rett syndrome,[73] and dementia,[74] as well as anorexia nervosa[75] and ... "BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases". Nature Reviews. Neuroscience. 14 (6 ...
The influence of isotretinoin and 5-a reductase inhibitors in metaloproteases of connective tissue in patients with ance] (in ... The drug is associated with inflammatory bowel disease (IBD)-ulcerative colitis, but not Crohn's disease.[51] There are also ... It is used to treat harlequin-type ichthyosis, a usually lethal skin disease, and lamellar ichthyosis. It is a retinoid, ... Among others, actor James Marshall sued Roche over allegedly Accutane-related disease that resulted in removal of his colon.[81 ...
Mast cells are a type of innate immune cell in connective tissue and the mucous membranes. They are intimately associated with ... Stvrtinová, Viera; Ján Jakubovský and Ivan Hulín (1995). Inflammation and fever; from Pathophysiology: principles of disease. ... It sets up a physical barrier against the spread of infection, and promotes healing of damaged tissue after the clearance of ... Dendritic cells (DC) are phagocytic cells present in tissues that are in contact with the external environment, mainly the skin ...
Mast cells are a type of innate immune cell that reside in connective tissue and in the mucous membranes. They are intimately ... "Pathophysiology: Principles of Disease. Computing Centre, Slovak Academy of Sciences: Academic Electronic Press. Archived from ... swelling of affected tissues, such as the upper throat during the common cold or joints affected by rheumatoid arthritis; ... Most leukocytes differ from other cells of the body in that they are not tightly associated with a particular organ or tissue; ...
PDGF is a required element in cellular division for fibroblasts, a type of connective tissue cell that is especially prevalent ... Kumar, Vinay (2010). Robbins and Coltran Pathologic Basis of Disease. China: Elsevier. pp. 88-89. ISBN 978-1-4160-3121-5. .. ... Like many other growth factors that have been linked to disease, PDGF and its receptors have provided a market for receptor ... During later maturation stages, PDGF signalling has been implicated in tissue remodelling and cellular differentiation, and in ...
Another reason for an inflammatory response may be due to an alteration of the dermal connective tissue. This is theorized ... and renal disease to help bolster the diagnosis of Kyrle disease. Other underlying diseases that Kyrle disease is observed with ... Kyrle disease is a rare disease unless there is a high count of patients with chronic renal failure. The disease seems to be ... This causes an inflammatory response which results with the keratin, along with other cellular material and connective tissue, ...
They are often due to damage of blood vessels and connective tissue cells. Many late effects are reduced by fractionating ... Radiation therapy is used to treat early stage Dupuytren's disease and Ledderhose disease. When Dupuytren's disease is at the ... valvular heart disease, coronary artery disease, heart arrhythmia and peripheral artery disease. Radiation-induced fibrosis, ... Cardiovascular disease. Radiation can increase the risk of heart disease and death as observed in previous breast cancer RT ...
心包填塞常見的病因包含癌症、腎衰竭、胸腔損傷(英语:chest trauma)和心包炎[2]。其他病因包括結締組織病(英语
A bronchopulmonary segment is a division of a lung separated from the rest of the lung by a septum of connective tissue. This ... It can have multiple variations and, although usually asymptomatic, it can be the root cause of pulmonary disease such as a ... The surrounding tissue secretes mucus normally but builds up and becomes distended.[16] This can lead to regional emphysema.[17 ... Many sufferers of chronic bronchitis also suffer from chronic obstructive pulmonary disease (COPD), and this is usually ...
One such feature is fully broadened neural arches, which act as insertion sites for connective tissues and ligaments in a ...
This was the first time this abnormal disease affecting cartilage and connective tissue was observed and analysed. His ... Anti-germ theory of diseasesEdit. Virchow did not believe in the germ theory of diseases, as advocated by Louis Pasteur and ... Virchow's disease, leontiasis ossea, now recognized as a symptom rather than a disease ... present in mature tissue.[40] Virchow believed that cancer is caused by severe irritation in the tissues, and his theory came ...
"Mixed Connective Tissue Disease (MCTD)". MedicineNet.com.. *. Nevares AM, Larner R. "Mixed Connective Tissue Disease (MCTD): ... "Mixed Connective Tissue Disease, MCTD". The Free Dictionary by Farlex.. *^ Nevares AM, Larner R. "Mixed Connective Tissue ... Autoimmune Disorders of Connective Tissue". Merck Manual Home Health Handbook.. *^ a b "Mixed connective tissue disease - ... Mixed connective tissue disease commonly abbreviated as MCTD, is an autoimmune disease characterized by the presence of ...
... is a rare autoimmune disorder featuring signs and symptoms of three different disorders: lupus ... Mixed Connective Tissue Disease. What is Mixed Connective Tissue Disease?. Mixed connective tissue disease (MCTD) is a rare ... Mixed Connective Tissue Disease Causes. No one knows exactly what causes the immune system to attack the bodys tissues in ... Mixed Connective Tissue Disease Symptoms. Symptoms of the different diseases that make up MCTD usually dont begin at the same ...
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Mixed connective tissue disease - Mixed connective-tissue disease (MCTD) is a disorder in which features of various connective- ... A connective tissue disease (collagenosis) is any disease that has the connective tissues of the body as a target of pathology ... Undifferentiated connective tissue disease (UCTD) is a disease in which the body mistakenly attacks its own tissues. It is ... Merck Manual: Musculoskeletal and connective tissue disorders Merck Manual: Inherited connective tissue disorders Arthritis ...
Collagen diseases, Connective Tissue Diseases, Connective Tissue, Diseases, Connective tissues, Internet Archive Wishlist ... Connective tissue diseases by Graham R. V. Hughes; 4 editions; First published in 1977; Subjects: ... Collagen diseases, Connective Tissue Diseases, Connective Tissue, Diseases, Connective tissues, Internet Archive Wishlist ... You could add Connective tissue diseases to a list if you log in. ... Are you sure you want to remove Connective tissue diseases from ...
Undifferentiated connective tissue disease (UCTD) is a disease in which the body mistakenly attacks its own tissues. It is ... Mixed connective tissue disease. In: George C. Tsokos. Modern Therapeutics in Rheumatic Diseases. Humana Press; 2002. doi: ... June 2011). "Undifferentiated connective tissue disease presenting with prevalent interstitial lung disease: Case report and ... August 2009). "Undifferentiated connective tissue disease: a seven-center cross-sectional study of 184 patients". Clinical ...
Get information on mixed connective tissue disease (MCTD) symptoms, types, treatment, and prognosis. ... People with mixed connective tissue disease (MCTD) have systemic lupus erythematosus, scleroderma, and polymyositis. ... Mixed Connective Tissue Disease vs. Undifferentiated Connective Tissue Disease). *How Does Mixed Connective Tissue Disease ( ... Connective Tissue (CT) Disease. Connective tissue disease is when the bodys connective tissues come under attack, possibly ...
Get information on mixed connective tissue disease (MCTD) symptoms, types, treatment, and prognosis. MCTD is an overlap of ... What are signs and symptoms of mixed connective tissue disease?. *What types of doctors treat mixed connective tissue disease? ... Mixed connective tissue disease is considered an overlap of three connective tissue diseases, systemic lupus erythematosus, ... Connective tissue diseases are disorders featuring abnormalities involving the collagen and elastin. Connective tissue diseases ...
Connective-tissue disease definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. ... Any of a group of noninheritable diseases that affect the connective tissue, such as rheumatic fever and rheumatoid arthritis, ... connective-tissue disease. .css-7w6khc{padding-top:20px;}. .css-1oucjfz{list-style-type:none;line-height:22px;}. *connection ... connective-tissue disease. in Medicine. .css-e1plaw{font-weight:normal;word-break:break-word;display:inline-block;font-size: ...
Mixed connective tissue disease has signs and symptoms of multiple disorders, making it difficult to diagnose. Theres no cure ... The precise cause of mixed connective tissue disease isnt known.. Mixed connective tissue disease is an autoimmune disorder. ... com/professional/musculoskeletal-and-connective-tissue-disorders/autoimmune-rheumatic-disorders/mixed-connective-tissue-disease ... In mixed connective tissue disease, the symptoms of the separate diseases usually dont appear all at once. Instead, they tend ...
Connective tissue diseases are autoimmune diseases. They include systemic lupus, scleroderma, polymyositis, dermatomyositis, ... Connective tissue diseases are actually a group of medical diseases. A connective tissue disease is any disease that has the ... A common symptom of connective tissue (CT) disease is nonspecific fatigue. Depending on which connective tissue disease is ... Many connective tissue diseases feature abnormal immune system activity with inflammation in tissues as a result of an immune ...
2009 ESC/ERS pulmonary hypertension guidelines and connective tissue disease.. Nakanishi N1; European Society of Cardiology; ... PAH is a common and fatal complication of connective tissue disease (CTD), but pulmonary hypertension in CTD consists of PAH, ... Pulmonary hypertension due to left heart disease; Pulmonary hypertension due to lung disease and/or hypoxia; Chronic ... MalaCards for pulmonary hypertension owing to lung disease and/or hypoxia - The Weizmann Institute of Science GeneCards and ...
Lung involvement is common in patients who have complications of connective tissue disease (CTDs) and causes considerable ... Pulmonary Complications of Connective Tissue Diseases Clin Chest Med. 2008 Mar;29(1):149-64, vii. doi: 10.1016/j.ccm.2007.11. ... Lung involvement is common in patients who have complications of connective tissue disease (CTDs) and causes considerable ...
UCTD stands for Undifferentiated Connective Tissue Disease. UCTD is defined as Undifferentiated Connective Tissue Disease ... Undifferentiated connective tissue disease and its cutaneous manifestations.. Undifferentiated connective tissue disease: a ... of 28 patients with undifferentiated connective tissue disease and interstitial lung disease in one study (Am. ... Given the evidence that solvents might cause scleroderma and undifferentiated connective tissue disease (signs, symptoms and ...
Home , September 2012 - Volume 18 - Issue 6 , Hand Angiography in Connective Tissue Disease ... Hand Angiography in Connective Tissue Disease. Pua, Uei MBBS, MMed, FRCR, FAMS ...
Mixed connective tissue disease. Curr Opin Rheumatol. 2000;12:386-90.. Maddison PJ. Mixed connective tissue disease: overlap ... Individuals with mixed connective tissue disease have symptoms that overlap with those of two or more connective tissue ... Mixed connective tissue disease (MTCD) is an uncommon systemic inflammatory rheumatic disease. MCTD is a specific subset of the ... Greidinger EL, Mixed Connective Tissue Disease, In: Encyclopedia of Medical Immunology: Autoimmune Diseases, MacKay I and Rose ...
... journal that provides a platform for clinicians and basic scientists interested in cerebral circulation and associated diseases ... Because of the wide distribution of connective tissues within the human body, diseases that affect connective tissue cells or ... The connective tissue is a basic type of tissue providing structural and metabolic support for other tissues and organs ... several connective tissue diseases can present with stroke. While some of these diseases have been recognized for decades as ...
Connective tissue diseases include systemic lupus erythematosus, rheumatoid arthritis, scleroderma, polymyositis, and ... Connective Tissue Disease. A connective tissue disease is any disease that has the connective tissues of the body as a primary ... Histopathology of Lung Disease in the Connective Tissue Diseases (CTD). This article will cover the pulmonary pathologies seen ... Connective Tissue Disease (CTD). Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read ...
... a collection of diseases that affect the parts of your body that hold internal structures together. These include autoimmune ... What are connective tissue diseases?. A connective tissue disease is any disease that affects the parts of the body that ... Undifferentiated connective tissue disease(s): Conditions that have characteristics of connective tissue diseases but dont ... What are the symptoms of connective tissue diseases?. Because there are so many different kinds of connective tissue diseases, ...
Connective Tissue by Medical Professionals (eBook) online at Lulu. Visit the Lulu Marketplace for product details, ratings, and ... Buy Complete Medical Guide for Disease Volume IX: ... Complete Medical Guide for Disease Volume IX: Connective Tissue ... Connective tissue is a fibrous and most diverse tissue. It is one of the four traditional classes of tissues (the others being ... form the pliable connective tissue as a whole. Connective tissue makes up a variety of physical structures including tendons ...
Autoimmune Diseases. Connective Tissue Disease. Scleroderma. Silicone Device Implants. Silicone Injection. Idiopathic ... Study of Silicone-Associated Connective Tissue Diseases. The safety and scientific validity of this study is the responsibility ... Clinical spectrum of connective tissue disease after cosmetic surgery. Observations on eighteen patients and a review of the ... Epidemiologic, Immunologic, and Immunogenetic Factors in Silicone-Associated Connective Tissue Diseases. Study Start Date :. ...
Mixed connective tissue disease has features of several connective tissue diseases, such as systemic lupus erythematosus, ... Mixed connective tissue disease presenting as a peculiar myositis with poor muscle regeneration. Mixed connective tissue ... profiles of mixed connective tissue disease (MCTD) differ distinctly from the profiles of clinically related connective tissue ... Mixed Connective Tissue Disease (MCTD). Author: Shelley Ensz. Scleroderma is highly variable. See Types of Scleroderma. Read ...
... mixed connective tissue disease, and multiple autoimmune syndrom were noted. TB was localized in 95% of cases, readily ... during the follow-up of Connective tissue diseases (CTD) is a particular situation often posing real diagnostic problems. This ... The respective medians diagnostic delays for systemic disease and TB were 21 months and 5 months. Tuberculin intradermal ... "Immunosuppressive Treatment of Connective Tissue Disease and Occurrence of Tuberculosis" written by M. Dieng, B. Djiba, B. S. ...
... , such as limited cutaneous systemic ... Pulmonary arterial hypertension is commonly associated with connective tissue diseases, such as limited cutaneous systemic ... Pulmonary vascular disease leading to pulmonary arterial hypertension may occur secondary to interstitial lung disease ( ... The two principal clinical manifestations are interstitial lung disease and pulmonary vascular disease. ...
... and connective tissue disease (CTD) associated interstitial lung disease (CTD-ILD) Bridget Collins, Sheetu Singh, Jyotsna Joshi ... OSA with intertitial lung diseases Sema Saraç, Gulgun Çetintas, Murat Kavas, Özlem Oruç, Özgür Bilgin Topçuoglu, Cüneyt Saltürk ... Which are the interstitial lung diseases where core needle biopsy has diagnostic utility? Maria João Oliveira, Tiago Pereira, ... Gastro-oesophageal dismotility measurements in scleroderma-associated interstitial lung disease: Correlation with respiratory ...
... as a prognostic biomarker in interstitial lung diseases associated with connective tissue diseases Tsutomu Hamada, Takuya ... Interstitial lung disease in the connective tisssue disease Samira Aouadi, Asma Sebai, Houda Gharsalli, Houda Snene, Najla ... Cystic lung disease with pulmonary amyloidosis: Analysis of 21 patients Ana Zamora, Darin White, Anne-Marie Sykes, Joanne Yi, ... Clinical course and outcome of vasculitis related interstitial lung disease Bo Young Lee, Sang Min Lee, Joon Seon Song, Jin Woo ...
Pulmonary Manifestations and Progression of Lung Disease in Juvenile-onset Mixed Connective Tissue Disease.. Hetlevik SO1,2, ... AUTOANTIBODIES; INTERSTITIAL LUNG DISEASE; MIXED CONNECTIVE TISSUE DISEASE; OUTCOME RESEARCH; PEDIATRIC RHEUMATOLOGY; PULMONARY ... To assess the occurrence and extent of interstitial lung disease (ILD) in patients with juvenile mixed connective tissue ... ILD was present in 27% of patients after a mean 16 years of disease duration, mostly as mild disease, and did not progress. ILD ...
A Raas-Rothschild, R Bargal, O Goldman, E Ben-Asher, J E M Groener, A Toutain, E Stemmer, Z Ben-Neriah, H Flusser, F A Beemer, M Penttinen, T Olender, A J J T Rein, G Bach, M Zeigler ...
What is connective tissue disease?. Connective Tissue Disease. A connective tissue disease is any disease that has the ... connective tissue diseases and .... Mixed Connective Tissue Disease. ... In medicine, mixed connective tissue disease (also ... connective tissue disease, asbestosis, drug reactions) central (e.g ... cryptogenic fibrosing alveolitis, connective tissue ... Many connective tissue diseases feature abnormal immune system activity with inflammation in tissues as a result of an immune ...
Talk:Connective tissue disease (transclusion) ‎ (← links). *Connective tissue disease/Related Articles (transclusion) ‎ (← ... Template:Connective tissue disease/Metadata (transclusion) ‎ (← links). *Connective tissue disease/Definition (transclusion) ‎ ... Pages that link to "Template:Connective tissue disease/Metadata". ← Template:Connective tissue disease/Metadata ... The following pages link to Template:Connective tissue disease/Metadata: View (previous 50 , next 50) (20 , 50 , 100 , 250 , ...
  • Mixed connective tissue disease commonly abbreviated as MCTD , is an autoimmune disease characterized by the presence of elevated blood levels of a specific autoantibody, now called anti-U1 ribonucleoprotein (RNP) together with a mix of symptoms of systemic lupus erythematosus (SLE), scleroderma , and polymyositis . (wikipedia.org)
  • MCTD was characterized as an individual disease in 1972 by Sharp et al. (wikipedia.org)
  • It is sometimes said to be the same as undifferentiated connective tissue disease , [1] but other experts specifically reject this idea [7] because undifferentiated connective tissue disease is not necessarily associated with serum antibodies directed against the U1-RNP , and MCTD is associated with a more clearly defined set of signs/symptoms. (wikipedia.org)
  • The absence of severe renal disease is a marker of MCTD. (wikipedia.org)
  • Central nervous system involvement (CNS): The original description of this disease stressed the absence of changes to the CNS, however, there have been trigeminal neuropathies (cranial nerve V), sensorineural hearing loss, and headaches observed in patients with MCTD. (wikipedia.org)
  • Symptoms of the different diseases that make up MCTD usually don't begin at the same time. (arthritis.org)
  • Diagnosing MCTD can be difficult because the symptoms of the three diseases usually occur one after another over a long period of time. (arthritis.org)
  • Treatment for MCTD depends on which organs are involved and the severity of the disease. (arthritis.org)
  • Mixed connective tissue disease ( MCTD ) is a rare autoimmune disorder characterized by certain symptoms shared by lupus , scleroderma , polymyositis or dermatomyositis , and rheumatoid arthritis . (medicinenet.com)
  • Overlapping criteria for diagnosis of mixed connective tissue disease (MCTD) have been published by Sharp, Alarcón-Segovia, Kasukawa, and Kahn. (medscape.com)
  • MCTD (mixed connective tissue disease) is a label attached to an uncommon subset of autoimmune diseases that have variable features of several autoimmune diseases including systemic lupus (SLE), scleroderma, polymyositis, dermatomyositis, and rheumatoid arthritis, but do not fulfill the diagnostic criteria for any of them. (newsmax.com)
  • MCTD may be a recognized autoimmune disease that hasn't fully developed, and it may, or may not, evolve into one of the more defined autoimmune syndromes later on. (newsmax.com)
  • my pcp just told me i have possible mctd, does anyone else experience soft tissue swelling? (healthboards.com)
  • What is the long-term outlook for people with mixed connective tissue disease (MCTD)? (clevelandclinic.org)
  • Since MCTD is comprised of a number of connective tissue disorders, there are many different possible outcomes, depending on the organs affected, the degree of inflammation, and how quickly the disease progresses. (clevelandclinic.org)
  • Mixed Connective Tissue Disease (MCTD) Accessed 6/02/2016. (clevelandclinic.org)
  • MCTD is a specific subset of the broader category of rheumatic "overlap syndromes", a term used to describe when a patient has features of more than one classic inflammatory rheumatic disease. (rarediseases.org)
  • MCTD lung disease may lead to breathing (respiratory) difficulties caused either by high blood pressure in the lungs (pulmonary hypertension) or by causing lung inflammation and scarring in and around the air sacs (interstitial lung disease). (rarediseases.org)
  • Kidney (renal) disease occurs much less often in MCTD than in lupus (10 percent of individuals with MCTD) and is often mild in MCTD. (rarediseases.org)
  • Among patients with MCTD, patterns of organ targeting have been reported that suggest disease subtypes. (rarediseases.org)
  • Mixed connective tissue disease (MCTD) is a rare autoimmune disorder which has overlapping features of various connective tissue diseases â€" lupus, scleroderma and polymyositis, and sometimes rheumatoid arthritis. (drugs.com)
  • The human leukocyte antigen (HLA) profiles of mixed connective tissue disease (MCTD) differ distinctly from the profiles of clinically related connective tissue diseases. (sclero.org)
  • Novel HLA alleles associated with MCTD and disease subsets were identified and DRB1*04:01 was confirmed as a major risk allele. (sclero.org)
  • Altogether, the data reinforce the notion of MCTD as a disease entity distinct from lupus, scleroderma and polymyositis. (sclero.org)
  • Mixed connective tissue disease (MCTD) is a rheumatological disease which has to be distinguished from other entities causing inflammatory myopathy. (sclero.org)
  • Digital (Finger) Ulcer from Mixed Connective Tissue Disease (MCTD). (sclero.org)
  • It was caused by secondary Raynaud's phenomenon, in a patient with Mixed Connective Tissue Disease (MCTD). (sclero.org)
  • Case Report) Scleroderma renal crisis in a newly diagnosed mixed connective tissue disease (MCTD) resulting in dialysis-dependent chronic kidney disease despite angiotensin-converting enzyme inhibition. (sclero.org)
  • Because MCTD is so rare, doctors really didn't know what to look for, and some of the tests now considered crucial for diagnosing this disease had not been developed yet. (infobarrel.com)
  • Population studies in Norway revealed the prevalence rate of MCTD to be 3.8 cases per 100,000 adults and the female-to-male ratio of this disease was 3.3. (infobarrel.com)
  • Undifferentiated connective tissue disease (UCTD) and mixed connective tissue disease (MCTD) are conditions that have some similarities to other systemic autoimmune or connective tissue diseases, but there are distinctions which make them different. (verywellhealth.com)
  • Patient was diagnosed as MCTD with interstitial lung disease. (thefreelibrary.com)
  • In a study by Gunnarasson et al of 126 patients with MCTD, 52% of them had HRCT features consistent with interstitial lung disease. (thefreelibrary.com)
  • Background Nailfold videocapillaroscopy (NVC) changes early appear in connective tissue diseases (CTDs): besides the "scleroderma pattern" of systemic sclerosis (SSc), abnormalities have been reported in mixed connective tissue disease (MCTD) and undifferentiated connective tissue disease (UCTD) [1]. (bmj.com)
  • The aim of our study was to assess the changes in pulmonary functional tests (PFTs) in various CTDs, including anti-synthetase syndrome (SYN), systemic sclerosis (SSc) and mixed connective tissue disorder (MCTD), following the use of rituximab therapy. (uzh.ch)
  • To study the survival rate and prognostic indicators of mixed connective tissue disease (MCTD) in a Hungarian population. (jrheum.org)
  • The prevalence of cardiovascular morbidity and mortality, malignancy, and thrombotic events increased during the disease course of MCTD. (jrheum.org)
  • In the early 1970s a new disease was added to the family of connective tissue diseases, denoted mixed connective tissue disease (MCTD). (jrheum.org)
  • Sharp, et al described MCTD as an "apparently distinct rheumatic disease syndrome associated with high titer of antibody to an extractable nuclear antigen" 1 , 2 . (jrheum.org)
  • In our previous study we reported that MCTD has heterogeneous clinical and serological characteristics, with varying disease course 16 . (jrheum.org)
  • Very little is known about the mortality, morbidity, and factors influencing the disease outcome in patients with MCTD. (jrheum.org)
  • The high number of deaths in MCTD is also associated with involvement of internal organs related to the disease, such as lung and cerebrovascular and renal disease, especially in childhood 24 , 25 . (jrheum.org)
  • [2] The idea behind the "mixed" disease is that this specific autoantibody is also present in other autoimmune diseases such as systemic lupus erythematosus, polymyositis, scleroderma, etc. (wikipedia.org)
  • Mixed connective tissue disease is considered an 'overlap' of three connective tissue diseases, systemic lupus erythematosus , scleroderma , and polymyositis . (rxlist.com)
  • Mixed connective tissue disease, as first described in 1972, is 'classically' considered an 'overlap' of three diseases, systemic lupus erythematosus, scleroderma, and polymyositis. (rxlist.com)
  • Mixed connective tissue disease has signs and symptoms of a combination of disorders - primarily lupus, scleroderma and polymyositis. (mayoclinic.org)
  • Connective tissue diseases are complex illnesses that can affect any part of the body, such as dermatomyositis/polymyositis , lupus , mixed connective tissue disease , rheumatoid arthritis , scleroderma , and Sjogren's . (sclero.org)
  • Mixed Connective Tissue Disease is an overlap of clinical features of systemic lupus erythematosus, systemic sclerosis, and polymyositis, along with very high ribonucleoprotein autoantibodies, but without antibodies for other specific autoimmune diseases. (sclero.org)
  • It's an autoimmune disorder that has features of three other diseases of connective tissue--Systemic Lupus Erythematosus, Scleroderma, and Polymyositis. (infobarrel.com)
  • Polymyositis is a disease which causes the muscles to become weak and inflamed. (ihealthdirectory.com)
  • Although most associated with rheumatoid arthritis, RF can also be seen in Sjogren syndrome, mixed connective tissue disease , mixed cryoglobulinemia, SLE, and polymyositis, as well as nonrheumatic disorders such as chronic infections, inflammatory disorders, and malignancy. (thefreedictionary.com)
  • Interstitial lung disease (ILD) is characterised by inflammation and scarring of the lung and is the leading cause of death in patients with systemic sclerosis, and contributes significantly to morbidity and mortality in many other connective tissue diseases (CTDs) such as polymyositis/dermatomyositis and mixed connective tissue disease. (centerwatch.com)
  • The SARDS include systemic lupus erythematosus (SLE) , Sjögren syndrome , mixed connective tissue disease /undifferentiated connective tissue disease, systemic sclerosis (also referred to as scleroderma), idiopathic inflammatory myopathies ​ (including polymyositis, dermatomyositis, and necrotizing autoimmune), and overlap syndromes (OSs). (arupconsult.com)
  • This is a large group which includes RHEUMATOID ARTHRITIS , STILL'S DISEASE (juvenile rheumatoid arthritis), infective ARTHRITIS , SYSTEMIC LUPUS ERYTHEMATOSUS , PROGRESSIVE SYSTEMIC SCLEROSIS , various forms of ARTERITIS , POLYMYOSITIS and DERMATOMYOSITIS . (thefreedictionary.com)
  • This dissertation describes the results of a population-based case-control study of risk factors for five connective tissue diseases: systemic lupus erythematosus, Sjogren's syndrome, systemic sclerosis/CREST syndrome, polymyositis/dermatomyositis and mixed connective tissue disease.Cases were female residents of King County, Washington who were diagnosed by a rheumatologist between January 1, 1983 and December 31, 1991 as having a disease of interest. (washington.edu)
  • A listing of Dermatomyositis (Connective Tissue Disease) medical research trials actively recruiting patient volunteers. (centerwatch.com)
  • Dermatomyositis (DM) is rare autoimmune disease of the muscles that is characterized by muscle weakness, a rash and inflammation of the muscles. (ihealthdirectory.com)
  • Undifferentiated connective tissue disease (UCTD) is a term suggested by LeRoy 30 years ago to denote autoimmune disease that does not meet criteria for established illnesses such as systemic lupus erythematosus, scleroderma, dermatomyositis, Sjogren's syndrome, vasculitis, or rheumatoid arthritis. (clinicaladvisor.com)
  • Since Raynaud's is a common feature of both UCTD and defined rheumatic disease (SLE, scleroderma, dermatomyositis and rheumatoid arthritis (RA) there have been efforts to define abnormalities morphologically as well as biochemically in the vasculature of these patients. (clinicaladvisor.com)
  • A second group of patients with primary Raynaud's was followed for almost five years and scleroderma loop pattern was seen antedating progression to scleroderma, dermatomyositis, overlap syndrome with scleroderma and mixed connected tissue disease. (clinicaladvisor.com)
  • When he tallied up patients with connective tissue disease -- such as rheumatoid arthritis, lupus, scleroderma or dermatomyositis -- there was a clear connection between CTD and increased risk of atherosclerotic cardiovascular disease. (uchicagomedicine.org)
  • Connective tissue diseases are disorders featuring abnormalities involving the collagen and elastin. (medicinenet.com)
  • In autoimmune disorders, your immune system - responsible for fighting off disease - mistakenly attacks healthy cells. (mayoclinic.org)
  • Cleveland Clinic offers expert diagnosis, treatment and rehabilitation for bone, joint or connective tissue disorders and rheumatic and immunologic diseases. (clevelandclinic.org)
  • Besides arteriopathies and metabolic disorders, several connective tissue diseases can present with stroke. (hindawi.com)
  • This paper discusses each of these connective tissue disorders and their relation with stroke briefly, emphasizing the main clinical features which can lead to their diagnosis. (hindawi.com)
  • or metabolic diseases (Fabry, homocystinuria), several connective tissue disorders (CTD) can involve ischaemic or haemorrhagic stroke as part of the phenotype in young adults. (hindawi.com)
  • Heritable disorders that involve connective tissue are among the most common genetic diseases in humans. (hindawi.com)
  • Classification also tends to overemphasize the aetiologic differences between severe genetic disorders that are apparent in infants or young children and the more common diseases that appear later in life. (hindawi.com)
  • Based on the two major constituents of the connective tissue, collagen and elastin, these disorders can be divided into "collagenopathies" and "elastinopathies" [ 5 , 6 ]. (hindawi.com)
  • Awareness for and recognition of such connective tissue disorders has a broad relevance as their identification has implications not only for counselling, recurrence risk and risk for associated manifestations, but also for management and prognosis. (hindawi.com)
  • This review describes select current biomarkers that aid in the diagnosis and treatment of several major systemic autoimmune connective tissue disorders and also newly proposed biomarkers. (sclero.org)
  • Acute Respiratory Events in Connective Tissue Disorders (CTDs). (sclero.org)
  • Investigation of Lung Involvement in Connective Tissue Disorders (CTD). (sclero.org)
  • These conditions can be caused by family genetics and are often known as heritable disorders of connective tissue. (clevelandclinic.org)
  • Group 3-Healthy volunteers who have had silicone implants or injections and did not develop symptoms or other medical features of connective tissue disorders. (clinicaltrials.gov)
  • Clinical spectrum of connective tissue disorders" (PDF). (wikipedia.org)
  • More than 200 disorders can affect a person's connective tissues. (opiates.com)
  • Infections can cause connective tissue disorders including cellulitis. (opiates.com)
  • The management and treatment of individual connective tissue disorders vary based on the actual disorder and its progression. (opiates.com)
  • To be sure, many of these connective tissue disorders involve pain and long-term suffering. (opiates.com)
  • ICD-9 code 710.8 for Other specified diffuse diseases of connective tissue is a medical classification as listed by WHO under the range -ARTHROPATHIES AND RELATED DISORDERS (710-719). (aapc.com)
  • As a consequence, there has never been more interest in capillaroscopy and contemporary research is actively evaluating both the additional utility of NFC within scleroderma-spectrum disorders as well as in other diseases characterised by microvasculopathy. (intechopen.com)
  • CTDs are a group of inflammatory, immune-mediated disorders that lead to subsequent tissue injury. (thermofisher.com)
  • Our pediatric rheumatology specialists provide highly specialized diagnosis and treatment for children and teens that have auto-immune diseases and disorders of the musculoskeletal system. (spectrumhealth.org)
  • mental confusion ("brain fog"), exhaustion, hair loss, dry eyes, depression, and "flu like symptoms that never go away" are just a few of the commonly reported health problems among women with implants that seem to be caused by connective tissue or autoimmune disorders. (breastimplantinfo.org)
  • At Spire Hartswood Hospital, I see patients with the full spectrum of rheumatic conditions including inflammatory arthritis such as rheumatoid, systemic rheumatic diseases such as lupus, metabolic bone diseases such as osteoporosis, non inflammatory conditions such as osteoarthritis, fibromyalgia and work related disorders. (spirehealthcare.com)
  • OBJECTIVES Interstitial lung disease (ILD) is a key prognostic factor in connective tissue disorders (CTDs). (uzh.ch)
  • Connective-tissue diseases (CTDs) manifest with a wide range of clinical findings and laboratory abnormalities. (medscape.com)
  • Lung involvement is common in patients who have complications of connective tissue disease (CTDs) and causes considerable morbidity and mortality. (nih.gov)
  • Mortality and causes of death across the systemic connective tissue diseases (CTDs) and the primary systemic vasculitides (PSVs). (sclero.org)
  • In CTDs the lungs significantly contribute to morbidity and mortality, since they constitute a common site of disease involvement. (sclero.org)
  • How are cancer and connective tissue diseases (CTDs) related to sarcoidosis? (sclero.org)
  • The association between sarcoidosis and both cancer and CTDs may yield important insights into the immunopathogenesis of all three diseases. (sclero.org)
  • Connective tissue diseases (CTDs) are associated with several interstitial lung diseases. (nih.gov)
  • It is emerging as a useful investigation in other CTDs characterised by microvasculopathy, such as in the idiopathic inflammatory myopathies and mixed connective tissue disease, as well as being studied as a serial investigation in patients to act as a potential biomarker and measure of treatment efficacy. (intechopen.com)
  • NFC can contribute to the earlier identification of patients with CTDs with clinically important complications and if applied accurately, therefore, can help improve outcomes in these often challenging diseases. (intechopen.com)
  • Connective tissue diseases (CTDs) are a group of closely related multisystem disease conditions with many overlapping clinical features. (thermofisher.com)
  • CTDs are generally rare diseases, although prevalence differs extensively. (thermofisher.com)
  • Serological tests reveal that connective tissue diseases (CTDs) are associated with a variety of autoantibodies. (thermofisher.com)
  • Diagnostic tests, in conjunction with a thorough clinical history, can be used to help diagnose CTDs earlier in the course of a patient's disease. (thermofisher.com)
  • We are a leading specialised tertiary centre for the care of patients with connective tissue diseases (CTDs). (royalfree.nhs.uk)
  • CTDs are a group of inflammatory autoimmune conditions that can affect the skin, along with other connective tissues such as joints and internal organs. (royalfree.nhs.uk)
  • Our research is focused on investigating the underlying causes of CTDs, the impact of related skin disease and new treatments. (royalfree.nhs.uk)
  • ILD is a group of conditions associated with many connective-tissue diseases, said Aryeh Fischer, MD, acting chief of the division of rheumatology at National Jewish Health in Denver. (the-rheumatologist.org)
  • I do a weekly connective tissue disease clinic in Basildon, in addition to combined Rheumatology/ Orthopaedics and Paediatrics/Rheumatology clinics. (spirehealthcare.com)
  • A 2016 epidemiological population based study found 3.6 years to be the average amount of time from the first manifestations of the disease until all the criteria for diagnosis were met. (wikipedia.org)
  • Doctors may suspect a diagnosis of mixed connective tissue disease after asking questions about the person's medical history and performing a physical examination. (arthritis.org)
  • Amigues JM, Cantagrel A, Abbal M, Mazieres B, and the Autoimmunity Group of the Hospitals of Toulouse (1996) Comparative study of 4 diagnosis criteria sets in mixed connective tissue disease in patients with anti-RNP antibodies. (springer.com)
  • Diagnosis of mixed connective tissue disease is supported by detecting abnormal antibodies in the blood . (rxlist.com)
  • However, each of these diseases can evolve slowly or rapidly from very subtle abnormalities before demonstrating the classic features that help in the diagnosis. (rxlist.com)
  • The diversity of signs and symptoms frequently complicates the diagnosis of a rheumatic disease. (medscape.com)
  • Its diagnosis is established by clinical features, antibodies to RNP (speckled antinuclear antibody to ribonucleoprotein antigen), hand swelling, joint aches, Raynaud's phenomenon, and the absence of antibodies specific for other autoimmune diseases. (newsmax.com)
  • A specialist in systemic autoimmune diseases, known as a rheumatologist, is usually required to establish the diagnosis. (nationaljewish.org)
  • Frequently, blood testing, X-ray examination, and other tests can help in making a diagnosis of connective tissue disease. (rxlist.com)
  • Most patients will maintain a diagnosis of undifferentiated connective tissue disease. (wikipedia.org)
  • Some diseases share common symptoms, making the diagnosis of a specific rheumatic condition difficult. (opiates.com)
  • It is thought that 30% or fewer patients with undifferentiated connective tissue disease progress to a definitive diagnosis of a connective tissue disease. (verywellhealth.com)
  • In addition to its role in the diagnosis of SSc, highlighted by its inclusion in the most recent ACR/EULAR consensus classification criteria, NFC has been shown to predict disease activity, many organ-specific complications such as digital ulcers, pulmonary hypertension and interstitial lung disease, and even mortality. (intechopen.com)
  • Some patients with ILD may have features of a CTD, but not meet all of the criteria necessary to diagnosis a specific autoimmune disease. (uclahealth.org)
  • i,ii Conventionally, a diagnosis of allergic or autoimmune disease relies on the case history and a physical examination. (thermofisher.com)
  • Undifferentiated Connective Tissue Disease (UCTD) features symptoms of multiple auto-immune diseases, but doesn't fall into a specific diagnosis. (spectrumhealth.org)
  • Exagen also offers its newest panel, Avise SLE+ Connective Tissue, which is a comprehensive connective tissue disease diagnostic specifically created to help provide assistance with differential diagnosis of autoimmune diseases. (thefreedictionary.com)
  • These new assays will provide physicians the tools needed to further differentiate a positive ANA screen and guide them to a more specific Connective Tissue Disease (CTD) diagnosis. (thefreedictionary.com)
  • Concerns are that these at-risk individuals may be discharged prematurely or be observed in an inefficient 'watch and wait' fashion until the diagnosis is clear, by which time the potential to prevent disease and confer the most benefit may be lost," Dr. Yusof and his colleagues wrote in their study. (mdedge.com)
  • Dong RP, Kimura A, Hashimoto H, Akizuki M, Nishimura Y, Sasazuki T (1993) Difference in HLA-linked genetic background between mixed connective tissue disease and systemic lupus erythematosus. (springer.com)
  • Hassfeld W, Steiner G, Studinicka-Benke A, Skriner K, Graninger W, Fisher I, Smolen JS (1995) Autoimmune response to the spliceosome: an immunologic link between rheumatoid arthritis, mixed connective tissue disease, and systemic lupus erythematosus. (springer.com)
  • Unclassifiable symptoms, physical examination findings, or serological results suggestive of a CTD frequently lead to diagnoses such as incomplete lupus, latent lupus, overlap syndrome, and undifferentiated connective-tissue disease (UCTD). (medscape.com)
  • See your doctor if you have signs and symptoms that interfere with your daily routine - particularly if you've already been diagnosed with lupus or another connective tissue disease. (mayoclinic.org)
  • Other diseases of connective tissue cannot be regularly defined by selected gene abnormalities, such as systemic lupus erythematosus or scleroderma . (rxlist.com)
  • Connective tissue diseases include autoimmune diseases like rheumatoid arthritis, scleroderma and lupus. (clevelandclinic.org)
  • The classic collagen vascular diseases include: Systemic lupus erythematosus (SLE) - An inflammation of the connective tissues, SLE can afflict every organ system. (wikipedia.org)
  • It is diagnosed when there is evidence of an existing autoimmune condition which does not meet the criteria for any specific autoimmune disease, such as systemic lupus erythematosus or scleroderma. (wikipedia.org)
  • Lupus is an inflammatory disease that is known to attack several organs. (infobarrel.com)
  • Lupus is an autoimmune disease. (ihealthdirectory.com)
  • Lupus is a type of chronic inflammatory disease which occurs when the body's immune system turns against its own tissues and organs. (ihealthdirectory.com)
  • A total of 187 specimens from 142 subjects with rheumatoid arthritis, systemic lupus erythematosus, other connective tissue diseases, and controls were placed in cell culture. (rupress.org)
  • I also have at least two forms of arthritis, lupus, Fibromyalgia/Chronic Fatigue Syndrome, Sjögren's syndrome( also known as 'Sicca syndrome', is a systemic autoimmune disease in which immune cells attack and destroy the exocrine glands that produce tears), and Raynaud's disease. (experienceproject.com)
  • Neuropsychological assessment in mixed connective tissue disease: comparison with systemic lupus erythematosus. (biomedsearch.com)
  • Systemic Lupus Erythematosus (SLE) is an immunologically mediated disease occurring most frequently in a female population of child-bearing age with target organs potentially in any body system. (annals.org)
  • Several recent publications have brought to attention the fact that the fetus of a mother with systemic lupus erythematosus is also at risk to develop complications of its mother's disease. (annals.org)
  • Systemic Lupus Erythematosus, Sjögren Syndrome, and Mixed Connective Tissue Disease in Children and Adolescents. (annals.org)
  • A study based on medical records from more than a quarter million adult patients found that African-American patients with connective tissue diseases such as lupus or rheumatoid arthritis were twice as likely as white patients to suffer from narrowed or atherosclerotic blood vessels, which increase the risk of a heart attack, stroke or death. (uchicagomedicine.org)
  • Using the 'pre-existing' control group, and with similar adjustment, for any CTD the odds ratio was 1.3 (95% CI: 0.4, 4.1), for systemic lupus erythematosus it was 1.6 (95% CI: 0.3, 7.3), and for Sjogren's syndrome the odds ratio was 1.8 (95% CI: 0.4, 7.8).We found little association between breast implants and the connective tissue diseases studied. (washington.edu)
  • Any of a group of noninheritable diseases that affect the connective tissue, such as rheumatic fever and rheumatoid arthritis, and that are characterized by fever, pain, stiffness, and inflammation. (dictionary.com)
  • The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis . (citizendium.org)
  • Rheumatoid arthritis is one of the most common connective tissue diseases and can be inherited. (clevelandclinic.org)
  • However, about one third of UCTD patients will differentiate to a specific autoimmune disease, like rheumatoid arthritis or systemic sclerosis. (wikipedia.org)
  • Patients with rheumatoid arthritis (RA) and scleroderma and systemic sclerosis (SSc) may develop interstitial lung disease (ILD), which affects a patient's breathing and quality of life. (the-rheumatologist.org)
  • In order to fulfill the criteria for UCTD, antinuclear antibodies must be present, along with a disease duration of at least 3 years. (medscape.com)
  • If the disease duration is less than 3 years, patients may be defined as having an early UCTD. (medscape.com)
  • It is often difficult to diagnose undifferentiated connective tissue disease (UCTD). (nationaljewish.org)
  • Sometimes, in the early stages, doctors simply refer to the 'undifferentiated' condition as a collagen vascular disease or undifferentiated connective tissue disease (UCTD) until more defined symptoms appear. (rxlist.com)
  • Undifferentiated connective tissue disease (UCTD) is a disease in which the body mistakenly attacks its own tissues. (wikipedia.org)
  • It is estimated that up to 25 percent of people with systemic autoimmune disease could be considered to have UCTD. (wikipedia.org)
  • Disease presentation varies widely from patient to patient, as UCTD is by definition nonspecific. (wikipedia.org)
  • Severe vitamin D deficiency has been associated with the progression of UCTD into defined connective tissue diseases. (wikipedia.org)
  • Undifferentiated connective tissue diseases (UCTD): a review of the literature and a proposal for preliminary classification criteria" (PDF). (wikipedia.org)
  • Usually, treatment for UCTD consists of some combination of analgesics and NSAIDs to treat pain, topical corticosteroids for skin and mucous tissue, and Plaquenil (hydroxychloroquine) as a disease-modifying anti-rheumatic drug (DMARD). (verywellhealth.com)
  • Patients with UCTD with low vitamin D levels have been reported to have a higher rate of progression to defined connective tissue disease. (clinicaladvisor.com)
  • Symptoms of undifferentiated connective tissue disease (UCTD) present differently from person to person. (spectrumhealth.org)
  • It can present as pleural effusion , pulmonary hypertension , interstitial lung disease , thromboembolic disease , and others. (wikipedia.org)
  • Esther JH, Sharp GC, Agia G, Hurst DJ, Maricq HR (1981) Pulmonary hypertension in a patient with connective tissue disease and antibody to nuclear ribonucleoprotein. (springer.com)
  • Graziano FM, Friedman LCV, Grossmaen J (1983) Pulmonary hypertension in a patient with mixed connective tissue disease. (springer.com)
  • 2009 ESC/ERS pulmonary hypertension guidelines and connective tissue disease. (nih.gov)
  • PAH is a common and fatal complication of connective tissue disease (CTD), but pulmonary hypertension in CTD consists of PAH, pulmonary hypertension caused by myocardial involvement, pulmonary veno-occlusive disorder, pulmonary hypertension due to interstitial lung disease. (nih.gov)
  • Pulmonary hypertension (PAH) in connective tissue diseases (CTD): an update. (sclero.org)
  • Determining the necessity for right heart catheterization (RHC) in pulmonary hypertension (PH) associated with connective tissue diseases (CTD) assessed by echocardiography. (sclero.org)
  • Mixed Connective Tissue Disease consists of the following core clinical and laboratory features: Raynaud phenomenon, swollen hands, arthritis/arthralgia, acrosclerosis, esophageal dysmotility, myositis, pulmonary hypertension, high level of anti-U1-RNP antibodies, and antibodies against U1-70 kd small nuclear ribonucleoprotein (snRNP). (sclero.org)
  • This session describes the spectrum of connective tissue disease and define the different types of pulmonary hypertension (PH) encountered. (phassociation.org)
  • Given the evidence that solvents might cause scleroderma and undifferentiated connective tissue disease (signs, symptoms and laboratory abnormalities that suggest a connective tissue disease, but which do not meet criteria for any specific rheumatic disease) (4,5), these increased rates of severe RP could be early preclinical scleroderma or another connective tissue disease. (acronymfinder.com)
  • A new study now proposes that patients with systemic sclerosis and overlapping features of another connective tissue disease might form a distinct disease subset. (sclero.org)
  • A nationwide epidemiological survey on diffuse collagen diseases: Estimation of prevalence rate in Japan. (medscape.com)
  • The connective tissues are composed of two major structural molecules, collagen and elastin . (rxlist.com)
  • There are many different collagen proteins that vary in amount in each tissue of the body. (rxlist.com)
  • There are many different types of collagen protein that vary in amount in each of the body's tissues. (rxlist.com)
  • In patients with connective tissue diseases, it is common for collagen and elastin to become injured by inflammation. (rxlist.com)
  • Diseases in which inflammation or weakness of collagen tends to occur are also referred to as collagen diseases. (rxlist.com)
  • Collagen vascular disease is a somewhat antiquated term used to describe diseases of the connective tissues that typically include diseases that can be (but are not necessarily) associated with blood vessel abnormalities. (rxlist.com)
  • While some of these diseases have been recognized for decades as causes of stroke, such as the vascular Ehlers-Danlos syndrome, others only recently came to attention as being involved in stroke pathogenesis, such as those related to Type IV collagen. (hindawi.com)
  • Connective tissues are made up of two proteins: collagen and elastin. (clevelandclinic.org)
  • When a patient has a connective tissue disease, the collagen and elastin are inflamed. (clevelandclinic.org)
  • These tissues form a framework, or matrix, for the body, and are composed of two major structural protein molecules: collagen and elastin. (wikipedia.org)
  • Collagen vascular diseases can be (but are not necessarily) associated with collagen and blood vessel abnormalities and that are autoimmune in nature. (wikipedia.org)
  • Hypermobility spectrum disorder Osteogenesis imperfecta (brittle bone disease) - caused by poor quality collagen, or insufficient amounts of normal collagen (primarily type I), necessary for healthy, strong bones and certain other connective tissues. (wikipedia.org)
  • Alport syndrome - defects in collagen (type IV), found in the renal basement membrane, inner ear and eyes, leading to glomerulonephritis, hearing loss, and eye disease, respectively. (wikipedia.org)
  • The classic collagen vascular diseases have a "classic" presentation with typical findings that doctors can recognize during an examination. (wikipedia.org)
  • The prognosis for this disease is so variable that it's hard to make any prediction of future effects. (newsmax.com)
  • The prognosis for undifferentiated connective tissue disease is surprisingly good. (verywellhealth.com)
  • Another commonly seen ILD in rheumatic diseases is nonspecific interstitial pneumonia, a condition with a better prognosis than UIP. (the-rheumatologist.org)
  • Recognition of the exact disease would affect treatment decisions and the prognosis for these patients. (the-rheumatologist.org)
  • This will be accomplished by comparing these patients to groups of appropriately matched patients with idiopathic scleroderma/systemic sclerosis without silicone exposure, and appropriately matched volunteers who have received similar silicone implants or injections and have not developed symptoms, physical examination findings, or laboratory abnormalities associated with autoimmune/connective tissue diseases. (clinicaltrials.gov)
  • Connective tissue diseases: systemic sclerosis: beyond limited and diffuse subsets? (sclero.org)
  • Pulmonary vascular disease leading to pulmonary arterial hypertension may occur secondary to interstitial lung disease (typically in diffuse cutaneous systemic sclerosis) or as an isolated process (typically in limited cutaneous systemic sclerosis). (kevinmd.com)
  • Pulmonary arterial hypertension is commonly associated with connective tissue diseases, such as limited cutaneous systemic sclerosis. (kevinmd.com)
  • This article reviews the associations of occupational and environmental exposures relevant to connective tissue diseases, and in particular systemic sclerosis. (journals.co.za)
  • Interstitial lung disease. (mayoclinic.org)
  • Nonspecific interstitial pneumonia was present in 4 (9%) of 47 patients with idiopathic interstitial lung disease and in 23 (83%) of 28 patients with undifferentiated connective tissue disease and interstitial lung disease in one study (Am. (acronymfinder.com)
  • Some patients have more myositis manifestations and have higher risk for interstitial lung disease. (rarediseases.org)
  • The most common histopathologic patterns of CTD-related interstitial lung disease are nonspecific interstitial pneumonia, usual interstitial pneumonia, organizing pneumonia, and lymphoid interstitial pneumonia. (sclero.org)
  • Histopathology of Lung Disease in the Connective Tissue Diseases (CTD). (sclero.org)
  • High-resolution CT of the chest shows no evidence of parenchymal lung disease. (kevinmd.com)
  • The two principal clinical manifestations are interstitial lung disease and pulmonary vascular disease. (kevinmd.com)
  • Lymphoid interstitial pneumonia is an interstitial lung disease characterized by lymphocytic infiltration of the pulmonary interstitium. (kevinmd.com)
  • Pulmonary Manifestations and Progression of Lung Disease in Juvenile-onset Mixed Connective Tissue Disease. (nih.gov)
  • Recent classification of interstitial lung disease by the American Thoracic Society has separated NSIP from usual interstitial pneumonitis (UIP). (clinicaladvisor.com)
  • The UCLA Connective Tissue Disease - Interstitial Lung Disease (CTD-ILD) Program is an integrative, patient-oriented program, affording patients the opportunity to receive comprehensive and coordinated care by experts in CTD-ILD. (uclahealth.org)
  • Connective tissue disease-associated interstitial lung disease (CTD-ILD) is a lung disease that may happen to some people with a connective tissue disease. (uclahealth.org)
  • A case of mixed connective tissue disorder with interstitial lung disease: case report. (thefreelibrary.com)
  • Interstitial lung disease, pulmonary vascular disease, aspiration pneumonia and pleurisy are common among which Interstitial Lung Disease is most common with an usual Interstitial Pneumonia (UIP) or Non-Specific Interstitial Pneumonia Pattern (NSIP). (thefreelibrary.com)
  • When ILD is extensive and/or progressive, immunosuppressive medication is often required to stabilize lung disease and alleviate symptoms. (centerwatch.com)
  • WASHINGTON, D.C.-Interstitial lung disease (ILD) is associated with a number of rheumatic diseases, and patients may be referred by pulmonologists to rheumatologists for management. (the-rheumatologist.org)
  • A panel of experts on connective tissue-associated ILD spoke at a session titled, "Connective Tissue Disease-Associated Interstitial Lung Disease," at the 2012 ACR/ARHP Annual Meeting , held here November 9-14. (the-rheumatologist.org)
  • Purpose To determine high resolution computed tomography (HRCT) patterns and pulmonary function indices which are associated with increased mortality in patients with connective tissue disease related fibrotic lung disease (CTD-FLD). (bmj.com)
  • Survival differences exist between idiopathic fibrotic lung disease (fibrotic IIP) and connective tissue disease related fibrotic lung disease (CTD-FLD) and therefore it is unclear if prognostic determinants in fibrotic IIP can be directly translated to CTD-FLD. (bmj.com)
  • 1 , 2 Connective tissue disease related fibrotic lung disease (CTD-FLD) most frequently presents as one of two radiological-histopathological phenotypes-usual interstitial pneumonia (UIP) or fibrotic non-specific interstitial pneumonia (NSIP). (bmj.com)
  • Unfortunately, because connective tissue disease-associated ILD is a rare lung disease, the research in this area is challenged due to the small number of potential participants. (the-rheumatologist.org)
  • Long-term survival of lung transplantation for interstitial lung disease associated with connective tissue diseases: a study of 26 cases from a referral centre. (medworm.com)
  • Elastin is the major component of ligaments (tissues which attach bone to bone). (rxlist.com)
  • The specific signs to suspect this disease is the presence of positive antinuclear antibodies (ANA), specifically anti-RNP, associated with Raynaud's phenomenon. (wikipedia.org)
  • In: Kasukawa R, Sharp GC (eds) Mixed Connective Tissue Disease and Antinuclear Antibodies. (springer.com)
  • Filep JG, Bodolay E, Sipka S, Gyimesi E, Csipoe I, Szegedi G (1995) Plasma endothelin correlate with antiendothelial antibodies in patients with mixed connective tissue disease. (springer.com)
  • Fritzler MJ, Ali R, Tan EM (1984) Antibodies from patients with mixed connective tissue disease react with heterogeneous nuclear ribonucleoprotein or ribonucleic acid (hn RNP/RNA) of the nuclear matrix. (springer.com)
  • Associations between anti-Ro52 antibodies and lung fibrosis in mixed connective tissue disease. (medscape.com)
  • Raynaud's phenomenon, antiphospholipid and antiendothelial cell antibodies, increased serum levels of proinflammatory cytokines and a reduced number of regulatory T cells were found to be associated with sensorineural hearing loss in mixed connective tissue disease patients. (sclero.org)
  • Antinuclear antibodies are supposed to target foreign invaders, but in the case of some autoimmune diseases, they mistakenly attack the proteins within the nucleus of a cell. (infobarrel.com)
  • This was confirmed in animal studies: The heart tissue of IL 11-treated mice showed an increase in connective tissue deposits in the myocardium, while the inhibition of IL 11 activity by antibodies reduced the production of connective tissue proteins. (mdc-berlin.de)
  • The researchers see these antibodies against IL 11 as suitable candidates for the development of an effective medication to prevent excessive connective tissue production. (mdc-berlin.de)
  • Laboratory testing for antinuclear antibodies (ANAs) and specific autoantibodies associated with the presence of SARDs may be useful in the evaluation of these diseases. (arupconsult.com)
  • Because the presence of anti-ENA antibodies is more predictive for SLE than the sole finding of ANAs (21) and because anti-ENA antibodies may be associated with connective tissue diseases other than SLE, we were interested in the sensitivity of IIF to detect ENAs. (thefreedictionary.com)
  • What are genetic risk factors for developing connective tissue disease? (rxlist.com)
  • Dr. Barnes and colleagues reviewed studies published prior to May 2017 and identified four studies that included 495 patients with ILD due to connective tissue disease. (the-rheumatologist.org)
  • Burdt MA, Hoffman RW, Dertscher SL, Wang GS, Johnson JC, Sharp GC (1999) Long-term outcome in mixed connective tissue disease: longitudinal clinical and serological findings. (springer.com)
  • Gendi NS, Welsh KI, van Venrooij WJ, Vancheeswaran R, Girloy J, Black CM (1995) HLA type as a predictor of mixed connective tissue disease differentiation: ten-year clinical and immunologic follow up of 46 patients. (springer.com)
  • Long-term outcome in mixed connective tissue disease: longitudinal clinical and serologic findings. (medscape.com)
  • Clinical and immunologic manifestations of mixed connective tissue disease in a Miami population compared to a Midwestern US Caucasian population. (medscape.com)
  • Each of these diseases has a characteristic presentation with typical clinical findings that doctors can recognize during an examination. (rxlist.com)
  • Clinical manifestations of mixed connective tissue disease. (mayoclinic.org)
  • Connective tissue disorder, that primarily affect women of childbearing age, have a variety of clinical forms, and are characterized by red scaly skin lesions. (citizendium.org)
  • Many of these updates promise to improve clinical care of patients who suffer from dermatologic involvement of these diseases and are the result of research performed by dermatologists. (sclero.org)
  • Clinical characteristics and survival in idiopathic pulmonary fibrosis (IPF) and connective tissue disease-associated usual interstitial pneumonia (CTD-UIP). (sclero.org)
  • A retrospective study was performed to investigate the clinical features and associated factors of invasive mycoses (IM) in patients with connective tissue disease (CTD) from Southern China. (springer.com)
  • The clinical syndrome was first described by Devic and Gault in 1894, and was considered a variant of multiple sclerosis (MS). A resurgence of interest has followed the recent identification of a disease-specific autoantibody, NMO-IgG, and its target antigen, the aquaporin 4 (AQP-4) receptor ( 1 ). (wiley.com)
  • The clinical course is characterized by disease relapse and significant morbidity in more than 90% of cases ( 2 ). (wiley.com)
  • These studies, together with the clinical observations relating to the association of more than one auto-immune disease in the same patient, and the detection of serologic abnormalities and related diseases in first-degree relatives of patients with certain of the connective tissue diseases, have led to new ideas concerning the pathogenesis. (annals.org)
  • If an ANA evaluation results in a negative immunoassay and a positive IFA assay, the reported ANA pattern and titer, along with the patient's clinical history and presentation, may be useful in determining which autoantibody test(s) to perform for disease confirmation. (arupconsult.com)
  • and clinical manifestations of each of the diseases, such as connective tissue diseases , pulmonary vasculitis, pneumonias, and smoking-related diseases, their radiologic patterns, histopathologic features, and management of disease processes. (thefreedictionary.com)
  • The clinical manifestations of IgG4-RD are usually tumor-like masses or organ enlargement, which result from dense tissue infiltration by immune cells and expansion of the extra-cellular matrix. (merckmanuals.com)
  • A disease that can cause inflammation of the connective tissue in every organ of the body, from the brain, skin, blood, to the lungs. (clevelandclinic.org)
  • Undifferentiated connective tissue disease and its cutaneous manifestations. (acronymfinder.com)
  • Imaging of Pulmonary Manifestations of Connective Tissue Diseases (CTD). (sclero.org)
  • This study will examine the possible relationship between silicone implants or injections and the connective tissue diseases scleroderma and myositis. (clinicaltrials.gov)
  • Raynaud's phenomenon is universal and almost always is present at the beginning of the disease course. (wikipedia.org)
  • Cold and numb fingers or toes (Raynaud's disease). (mayoclinic.org)
  • People with severe Raynaud's disease can develop gangrene in the fingers. (mayoclinic.org)
  • Other medications may be prescribed to treat or reduce the risk of certain complications of the disease. (arthritis.org)
  • With treatment mixed connective tissue disease worsens in about 13% of the people, causing potentially fatal complications within 6 to 12 years. (crowdrise.com)
  • Pulmonary complications are prominent and include diffuse pulmonary cysts, pneumothorax, chylous pleural effusions, and obstructive airways disease. (kevinmd.com)
  • Pulmonary complications are common in patients with connective tissue disease and pulmonary fibrosis in particular is an important cause of mortality. (bmj.com)
  • The majority of patients with undifferentiated connective tissue disease, perhaps 80%, have a simple autoantibody profile, often anti-Ro or anti-RNP autoantibodies. (verywellhealth.com)
  • Fibroblasts are the cells responsible for the production of connective tissue. (lulu.com)
  • Connective tissue diseases are often characterized by a variety of immune abnormalities that are common for each particular type of illness. (rxlist.com)
  • Diseases of connective tissue that are strictly inheritable (due to genetic inheritance ) include Marfan syndrome (can have tissue abnormalities in the heart , aorta , lungs , eyes, and skeleton ) and Ehlers-Danlos syndrome (may have loose, fragile skin or loose [ hyperextensible ] joints). (rxlist.com)
  • Other diseases of connective tissue do not have specific gene abnormalities as their sole cause. (rxlist.com)
  • This chapter will detail the relevant underlying scientific principles that underpin the investigation, the methods for performing NFC, the range of abnormalities that can be present and the currently available classification criteria before moving on to discuss the various established and emerging applications as relevant to the connective tissue diseases. (intechopen.com)
  • Treatment is often directed at suppressing the inflammation present in the tissues by using anti-inflammatory and immunosuppressive medications. (medicinenet.com)
  • Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. (citizendium.org)
  • Mixed connective tissue disease (MTCD) is an uncommon systemic inflammatory rheumatic disease. (rarediseases.org)
  • Rheumatic fever is defined as an inflammatory disease caused by the Group A streptococcus bacterium. (ihealthdirectory.com)
  • It is a chronic, inflammatory disease that often progresses to a more complex, systemic disorder that can affect other tissues and organs in the body such as joints, skin, kidneys, lungs, nervous system, and the intestinal tract. (thermofisher.com)
  • IgG4-RD accounts for about 25 to 50% of cases of inflammatory orbital disease (previously called orbital pseudotumor). (merckmanuals.com)
  • In this report we conclude normal inflammatory markers cannot be used as exclusion criteria for the disease. (medworm.com)
  • Uptake pattern of 68GaGa-DOTA-NOC in tissues: implications for inflammatory diseases. (medworm.com)
  • Within tissue variability, an SUVmax greater than the mean +3SD is rarely found amongst patients without a symptomatic chronic inflammatory process but, when found, may highlight a chronic inflammatory condition. (medworm.com)
  • One of the most serious connective tissue-associated ILDs is usual interstitial pneumonia (UIP), an idiopathic condition marked by a honeycombing pattern seen on radiographs and fibrosis, Dr. Fischer said. (the-rheumatologist.org)
  • For patients with connective tissue disease and biopsy proven usual interstitial pneumonia (UIP), survival differences exist between those presenting with a UIP pattern of disease on HRCT, than those without typical features of UIP on HRCT. (bmj.com)
  • What diseases characteristically affect connective tissue? (rxlist.com)
  • Because of the wide distribution of connective tissues within the human body, diseases that affect connective tissue cells or ECM proteins often have systemic effects. (hindawi.com)
  • Connective tissue disease is a group of autoimmune conditions marked by inflammation of the muscle fascias, ligaments and skin . (rxlist.com)
  • Connective tissue makes up a variety of physical structures including tendons and the connective framework of fibers in muscles, capsules and ligaments around joints, cartilage, bone, adipose tissue, blood and lymphatic tissue. (lulu.com)
  • pulmonary manifestation of connective tissue disease (CTD), leading to significant morbidity and mortality. (bioportfolio.com)
  • Treatment largely depends upon individual disease progression and the nature of presenting symptoms. (wikipedia.org)
  • There is a low risk of progression to a well-defined connective tissue disease, especially among patients who experience unchanged undifferentiated connective tissue disease for 5 years or more. (verywellhealth.com)
  • Given the potential for permanent disability following isolated attacks of myelitis or ON, efforts have been made to identify individuals at high risk for disease relapse or progression to full-spectrum NMO. (wiley.com)
  • Despite recent advances in treatment, PAH remains essentially untreatable even if pharmacological trials seem to slow down progression of the disease improving symptoms and quality of life of these patients. (eurekaselect.com)
  • Overlap of interstitial pneumonia with autoimmune features with undifferentiated connective tissue disease and contribution of UIP to mortality. (annals.org)
  • Other conditions that may be seen in rheumatic disease patients include lymphocytic interstitial pneumonia and, more rarely, severe acute interstitial pneumonia. (the-rheumatologist.org)
  • Research suggests there may be a genetic component because the disease may occur more often in people with a family history of the disease. (arthritis.org)
  • Currently, patients with autoimmune disease are believed to have a genetic predisposition. (medscape.com)
  • However, there are genetic patterns that are considered to increase the risk for developing connective tissue diseases. (rxlist.com)
  • It is likely that a combination of genetic risks and environmental factors are necessary for the development of connective tissue disease. (rxlist.com)
  • These connective tissue diseases occur for unknown reasons but may have weaker genetic factors that predispose to their development. (rxlist.com)
  • Though the genetic background of ischaemic and haemorrhagic stroke is often polygenetic or multifactorial, it can in some cases result from a monogenic disease, particularly in young adults. (hindawi.com)
  • Marfan syndrome - a genetic disease causing abnormal fibrillin. (wikipedia.org)
  • Genetic factors may create a predisposition towards developing these autoimmune diseases. (wikipedia.org)
  • The aim of the research genetic study was to investigate the association between variants (C1431T and Pro12Ala) of the peroxisome proliferator-activated receptor ( PPARgamma-2 ) gene, Trp64Arg polymorphism of the beta-3-adrenergic receptor gene and lipid profile in Polish population including group of 103 patients with connective tissue disease (CTD) and 103 sex- and age-matched controls in context of statin use. (dovepress.com)
  • This implies that the characteristic features that are used to define the classic connective tissue disease are not present, but some symptoms or signs of connective disease exist. (rxlist.com)
  • Individuals with undifferentiated connective tissue disease may never develop a fully definable condition or they may eventually develop a classic connective tissue disease. (rxlist.com)
  • These are considered classic connective tissue diseases. (rxlist.com)
  • In the later stages of the disease, the heart, lungs, kidney or other organs may be affected. (arthritis.org)
  • Mild disease usually responds to NSAIDs and anti-malarial drugs, while more aggressive disease that involves major organs may need immune suppressants and corticosteroid treatment. (newsmax.com)
  • The connective tissue is a basic type of tissue providing structural and metabolic support for other tissues and organs throughout the body. (hindawi.com)
  • An autoimmune condition that causes scar tissue to form in the skin, internal organs (including the GI tract), and small blood vessels. (clevelandclinic.org)
  • An autoimmune disease that affects cells in blood vessels in organs throughout the body. (clevelandclinic.org)
  • Connective tissue is any type of biological tissue with an extensive extracellular matrix that supports, binds together, and protects organs. (wikipedia.org)
  • Scleroderma - an activation of immune cells that produces scar tissue in the skin, internal organs, and small blood vessels. (wikipedia.org)
  • Scleroderma causes thickening and hardening of the skin, underlying tissues, and organs. (infobarrel.com)
  • Connective tissue or systemic autoimmune rheumatic diseases (SARDs) are characterized by autoantibodies that can affect tissues and organs throughout the body. (arupconsult.com)
  • Immunoglobulin G4-related disease (IgG4-RD) is a chronic immune-mediated fibroinflammatory disorder that often manifests with tumor-like masses and/or painless enlargement of multiple organs. (merckmanuals.com)
  • The study, published Feb. 4, 2016, in the open access Nature journal , Scientific Reports , also showed that the prevalence of narrowed blood vessels in patients with connective tissues disease (CTD) was particularly high in young African-Americans. (uchicagomedicine.org)
  • Connective tissue disease (CTD) increases risk for cardiovascular problems. (sclero.org)
  • Alarcon-Segovia D, Villarreal M (1987) Classification and diagnostic criteria for mixed connective tissue disease. (springer.com)
  • Alarcon-Segovia D, Cardiel MH (1989) Comparison between three diagnostic criteria for mixed connective tissue disease. (springer.com)
  • Doria A, Ghirardello A, de Zambiasi P, Ruffatti A, Gambari PF (1992) Japanese diagnostic criteria for mixed connective tissue disease in Caucasian patients. (springer.com)
  • Some of these disease criteria overlap, further complicating the diagnostic workup in patients with a potential CTD. (medscape.com)
  • Individuals with an overlap syndrome may, but need not meet, complete diagnostic criteria for one (or more than one) classic rheumatic disease. (rarediseases.org)
  • Diagnostic testing generally aims to determine whether a patient has a definite or undifferentiated connective tissue disease. (wikipedia.org)
  • Which are the interstitial lung diseases where core needle biopsy has diagnostic utility? (ersjournals.com)
  • As part of the diagnostic process for undifferentiated connective tissue disease, a complete medical history, physical examination, and laboratory testing is necessary to exclude the possibility of other rheumatic diseases. (verywellhealth.com)
  • Our objective was to identify the presence of NMOSD in patients with acute myelitis and suspected connective tissue disease (CTD), and to discuss the utility of this distinction in establishing a diagnostic and therapeutic plan. (wiley.com)
  • It relied on rigid diagnostic codes for complex multi-faceted diseases as well as simplified classifications of race. (uchicagomedicine.org)
  • It is hard to accurately determine whether posterior reversible encephalopathy syndrome in this case is a complication of cyclophosphamide or a condition that resulted from the mixed connective tissue disease flare-up. (sclero.org)
  • Alternatively, physicians may prescribe cyclophosphamide to treat patients with severe disease and/or rapidly progressing disease even though the immunosuppressant is associated with multiple side effects and is potentially toxic. (the-rheumatologist.org)
  • A new Cochrane Library review by Hayley Barnes, MBBS, a respiratory medicine physician at Monash University in Australia, and colleagues evaluated whether cyclophosphamide can help preserve lung function in patients with ILD due to connective tissue disease. (the-rheumatologist.org)
  • The team found that patients with ILD associated with connective tissue disease may realize a small benefit from cyclophosphamide treatment. (the-rheumatologist.org)
  • Cardiac involvement in mixed connective tissue disease: a systematic review. (medscape.com)
  • Disease of the lymph nodes (lymphadenopathy), enlargement of the spleen (splenomegaly), enlargement of the liver (hepatomegaly), and intestinal involvement may also occur in some cases. (rarediseases.org)
  • The cognitive deficits observed in connective tissue diseases can be connected with nervous system involvement. (biomedsearch.com)
  • A common symptom of connective tissue (CT) disease is nonspecific fatigue . (rxlist.com)
  • The signs and symptoms of mixed connective tissue disease vary greatly from one individual affected to another. (rxlist.com)
  • Corticosteroids are commonly used to manage the signs and symptoms of mixed connective tissue disease. (mayoclinic.org)
  • Researchers are working to identify proteins produced by the immune system that might cause mixed connective tissue disease. (mayoclinic.org)
  • There are a number of other matrix proteins, where fragmentation and release is increased in joint disease. (lu.se)
  • The term is sometimes used interchangeably with mixed connective tissue disease, an overlap syndrome. (wikipedia.org)
  • Treatment may include corticosteroids to reduce inflammation and immunosuppressive drugs to suppress the immune system and its attack on healthy tissue. (arthritis.org)
  • Dahl M, Chalmers A, Wade J, Calverley D, Munt B (1992) Ten year survival of a patient with advanced hypertension and mixed connective tissue disease treated with immunosuppressive therapy. (springer.com)
  • Patients with connective tissue diseases or acne, on immunosuppressive regimens, and with use of topical steroids within the previous 12 weeks were excluded. (thefreedictionary.com)
  • A connective tissue disease is any disease that has the connective tissues of the body as a primary target of pathology . (rxlist.com)
  • A connective tissue disease (collagenosis) is any disease that has the connective tissues of the body as a target of pathology. (wikipedia.org)