A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.
Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.
A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A vascular connective tissue formed on the surface of a healing wound, ulcer, or inflamed tissue. It consists of new capillaries and an infiltrate containing lymphoid cells, macrophages, and plasma cells.
Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.

Insulin regulation of amino acid transport in mesenchymal cells from avian and mammalian tissues. (1/275)

Insulin regulation of amino acid transport across the cell membrane was studied in a variety of mesenchymal cell directly isolated from avian and mammalian tissues or collected from confluent cultures. Transport activity of the principal systems of mediation in the presence and absence of insulin was evaluated by measuring the uptake of representative amino acids under conditions approaching initial entry rates. Insulin enhanced the transport rate of substrate amino acids from the A system(alpha-aminoisobutyric acid, L-proline, glycine, L-alanine and L-serine) in fibroblasts and osteoblasts from chick-embryo tissues, in mesenchymal cells (fibroblasts and smooth muscle cells) from immature rat uterus, in thymic lymphocytes from young rats and in chick-embryo fibroblasts from confluent secondary cultures. In these tissues, the uptake of amino acid substrates of transport systems L and Ly+ (L-leucine, L-phenylalanine, L-lysine) was not affected by the presence of the hormone. No insulin control of amino acid transport was detected in chick-embryo chondroblasts and rat peritoneal macrophages. These observations identify the occurrence of hormonal regulatory patterns of amino acid transport for different mesenchymal cells types and indicate that these properties emerge early during cell differentiation.  (+info)

Role of matrix metalloproteinases and their tissue inhibitors in the regulation of coronary cell migration. (2/275)

The migration of vascular cells is regulated by matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Because the activation of adventitial fibroblasts has been implicated in coronary repair, we have examined regional differences in cell outgrowth and the synthesis of MMPs/TIMPs in different layers of porcine coronary arteries. Coronary medial explants demonstrated significantly slower cell outgrowth than coronary adventitia in culture (P<0.001). These observations were paralleled by the predominant expression of TIMP-1 and -2 in the media (14-fold and 37-fold higher than in adventitia, respectively, P<0.001), whereas higher gelatinolytic activities (MMP-2 and -9) were released from adventitial explants. Smooth muscle cell outgrowth from the media was regulated by endogenous TIMPs, since TIMP inhibition (recombinant MMP-2 or neutralizing anti-TIMP antibodies) facilitated cell outgrowth (P<0.001). In contrast, the addition of recombinant TIMP-1 or -2 decreased adventitial cell outgrowth. In the coculture experiments, the presence of coronary media retarded adventitial cell outgrowth, whereas medial damage abrogated these effects, allowing for fibroblast migration (P<0.001). In conclusion, this study demonstrated differential migratory properties and distinct MMP/TIMP synthesis by coronary fibroblasts and smooth muscle cells. Endogenous TIMPs in the media may play an important role in maintaining coronary arterial wall homeostasis, whereas high levels of matrix-degrading activities confer the "invasive" characteristics of adventitial fibroblasts.  (+info)

Selective antibody blockade of lymphocyte migration to mucosal sites and mast cell adhesion. (3/275)

The integrins alpha4beta7 and alpha4beta1 mediate adhesion to the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and the vascular cell adhesion molecule-1 (VCAM-1) and are important in T cell and allergic inflammatory reactions in the rat. The relative contributions of alpha4beta7 and alpha4beta1 in these reactions is unknown. To examine the role of alpha4beta7 in the rat a new mAb, TA-6, was developed. TA-6 inhibited adhesion to MAdCAM-1 but not to VCAM-1, a characteristic of alpha4beta7 adhesion, and immunofluorescence and immunoprecipitation studies were compatible with binding to alpha4beta7. TA-6 blocked rat lymphocyte adhesion to mesenteric lymph nodes and T cell migration to mucosal lymphoid tissues and it bound to rat mucosal mast cells. TA-6 did not inhibit lymphocyte adhesion to peripheral lymph nodes and T cell migration to peripheral lymphoid tissues or cutaneous inflammatory sites, and was not expressed on connective tissue mast cells.  (+info)

Gi-mediated activation of mitogen-activated protein kinase (MAPK) pathway by receptor mimetic basic secretagogues of connective tissue-type mast cells: bifurcation of arachidonic acid-induced release upstream of MAPK. (4/275)

The family of basic secretagogues of connective tissue mast cells act as receptor mimetic agents, which trigger exocytosis by directly activating G proteins. We now demonstrate that pertussis toxin (Ptx)-sensitive Gi proteins, activated by compound 48/80 (c48/80), a potent member of this family, also activate the p42/p44 MAP kinases (MAPKs). This activation was potentiated by the protein tyrosine phosphatase inhibitor vanadate, whereas the tyrphostin AG-18, a competitive inhibitor of protein tyrosine kinases (PTKs); the protein kinase C inhibitors K252a and GF109203X; the phosphatidylinositol-3-kinase (PI-3K) inhibitors wortmannin and LY294002; and EGTA have abolished this activation. These results suggest that c48/80 activated the p42/p44 MAPKs via a mechanism that involves PTKs, protein kinase C, phosphatidylinositol-3-kinase and Ca2+ as mediators. Protein tyrosine phosphorylation and activation of the p42/p44 MAPKs were closely correlated with stimulation of arachidonic acid (AA) release by c48/80 but not with histamine secretion. However, whereas PD98059, the inhibitor of the MAPK kinase has abrogated MAPK activation, this inhibitor failed to effect release of AA. We therefore conclude that by activating Ptx-sensitive Gi protein(s), the basic secretagogues of mast cells stimulate multiple signaling pathways, which diverge to regulate the production and release of the different inflammatory mediators. Whereas the signaling pathway responsible for triggering histamine release is PTK independent, the pathway responsible for the stimulation of AA release bifurcates downstream to PTKs but upstream to the activation of MAPKs.  (+info)

Cyclic expression of mRNA transcripts for connective tissue components in the mouse ovary. (5/275)

In the ovary, differentiation of germinal cells into primordial follicles, functional ovulatory follicles and corpus luteum, all take place in a connective tissue matrix. We postulated that extracellular matrix (ECM) of the ovary participates actively in ovarian functions. To test this, the mRNA levels for several ECM components were determined in the mouse ovary at six distinct stages of the 4-day oestrous cycle. Northern analysis revealed statistically significant cyclic expression patterns for the mRNAs coding for type III, IV and VI collagens as well as for the small proteoglycan, biglycan, and for syndecan-1 and osteonectin. The cyclic changes observed in the mRNAs for these structural components exceeded those for matrix metalloproteinases (MMP)-2, -9 and -13, and for tissue inhibitors of matrix metalloproteinases (TIMP)-1, -2 and -3, where the changes were not statistically significant, despite their apparent role in ECM remodelling in the ovary. These observations support the hypothesis that cyclic changes in the production and degradation of ECM are part of normal ovarian function connected with follicular maturation, rupture and corpus luteum formation.  (+info)

Distribution of membrane cofactor protein (MCP/CD46) on pig tissues. Relevance To xenotransplantation. (6/275)

Membrane cofactor protein (MCP; CD46) is a 50-60 000 MW glycoprotein, expressed on a wide variety of cells and tissues in man, which plays an important role in regulating complement activation. Human MCP has also been shown to be the receptor for measles virus. We have recently identified the pig analogue of MCP and demonstrated that pig MCP has cofactor activity for factor I-mediated cleavage of C3b when these components are derived either from pig or human. As a consequence, pig MCP is an efficient regulator of the classic and alternative pathways of human and pig complement. In order to define the potential importance of MCP in protecting against complement activation in the pig, we have conducted a comprehensive survey of its distribution in pig cells and organs. As in humans, MCP in the pig is broadly and abundantly distributed. Pig MCP is highly expressed on all circulating cells, including erythrocytes, in contrast to its absence on human erythrocytes. Multiple isoforms of MCP are found on cells and in tissues, probably representing products of alternative splicing analogous to those found in man. MCP is abundantly expressed throughout all tissues examined with particularly strong staining on the vascular endothelium. Connective tissue elements within liver and testis are also strongly stained by anti-pig MCP antibodies. Pig MCP is expressed only weakly on skeletal muscle cells and expression is absent from smooth muscle cells in the lung and vessel walls, sites at which human MCP is expressed. Of particular note, MCP is not expressed in B-cell areas of the germinal centres of lymph nodes.  (+info)

Increased incidence of apoptosis in non-labour-affected cytotrophoblast cells in term fetal membranes overlying the cervix. (7/275)

A regional reduction in the cellularity of the cytotrophoblastic and decidual layers occurs in the fetal membranes overlying the cervix in the lower uterine segment prior to labour. Although the mechanism(s) involved are not known it could result from regionally increased apoptosis, the histological manifestation of programmed cell death, or decreased proliferation. Apoptosis was assessed in regionally sampled fetal membranes from women undergoing elective Caesarean section (n = 14) by the presence of apoptotic bodies by light and electron microscopy. Cell proliferation was assessed by immunocytochemical detection of the protein Ki-67. Apoptotic bodies were identified in all regions of the fetal membrane with the highest incidence found within the cytotrophoblast layer. However, this layer in fetal membranes biopsied over the cervix contained significantly more apoptotic bodies (mean +/- SD 0.085 +/- 0.020%) compared to the layer in fetal membranes obtained from the mid-zone (0.020 +/- 0.008%) apoptotic bodies. Isolated Ki-67 positive cells were detected in the cytotrophoblast layer, but no regional differences in their incidence were seen. Fetal membranes also failed to exhibit significant immunoreactivity for BCL-2 but exhibited strong BAX immunoreactivity within the decidual layer. We conclude that the regionally increased incidence of apoptosis in the cytotrophoblastic layer in the membrane overlying the cervix may account for the reduction in its cellularity but not the relative decrease in the decidual layer. Given the consequence of the loss of local function in degrading uterotonins and stabilizing the fetal membrane, the study of the regulation of apoptosis in these cells may have important implications for fetal membrane rupture and parturition.  (+info)

Lipopolysaccharide-activated macrophages stimulate the synthesis of collagen type I and C-fibronectin in cultured pancreatic stellate cells. (8/275)

We have recently identified and characterized pancreatic stellate cells (PSC) in rats and humans (Gastroenterology 1998, 15:421-435). PSC are suggested to represent the main cellular source of extracellular matrix in chronic pancreatitis. Now we describe a paracrine stimulatory loop between human macrophages and PSC (rat and human) that results in an increased extracellular matrix synthesis. Native and transiently acidified supernatants of cultured macrophages were added to cultured PSC in the presence of 0.1% fetal calf serum. Native supernatants of lipopolysaccharide-activated macrophages stimulated the synthesis of collagen type I 1.38 +/- 0.09-fold of control and c-fibronectin 1.89 +/- 0.18-fold of control. Transiently acidified supernatants stimulated collagen type I and c-fibronectin 2.10 +/- 0.2-fold and 2.80 +/- 0.05-fold of control, respectively. Northern blot demonstrated an increased expression of the collagen-I-(alpha-1)-mRNA and fibronectin-mRNA in PSC 10 hours after addition of the acidified macrophage supernatants. Cell proliferation measured by bromodeoxyuridine incorporation was not influenced by the macrophage supernatants. Unstimulated macrophages released 1.97 pg TGFbeta1/microgram of DNA over 24 hours and lipopolysaccharide-activated macrophages released 6.61pg TGFbeta1/microgram of DNA over 24 hours. These data together with the results that, in particular, transiently acidified macrophage supernatants increased matrix synthesis, identify TGFbeta as the responsible mediator. In conclusion, our data demonstrate a paracrine stimulation of matrix synthesis of pancreatic stellate cells via TGFbeta1 released by activated macrophages. We suggest that macrophages might play a pivotal role in the development of pancreas fibrosis.  (+info)

Many of the differentiated cells in the adult body can be grouped into families whose members are closely related by origin and by character. An important example is the family of connective-tissue cells, whose members are not only related but also unusually interconvertible. The family includes fibroblasts, cartilage cells, and bone cells, all of which are specialized for the secretion of collagenous extracellular matrix and are jointly responsible for the architectural framework of the body. The connective-tissue family also includes fat cells and smooth muscle cells. These cell types and the interconversions that are thought to occur between them are illustrated in Figure 22-45. Connective-tissue cells play a central part in the support and repair of almost every tissue and organ, and the adaptability of their differentiated character is an important feature of the responses to many types of damage.Figure 22-45The family of connective-tissue cells Arrows show the interconversions that are thought to
The present invention provides a new and improved method for preparing a composite bone graft. The method includes providing a bone marrow aspirate suspension and passing the bone marrow aspirate suspension through a porous, biocompatible, implantable substrate to provide a composite bone graft having an enriched population of connective tissue progenitor cells. Because the method is preferably performed intraoperatively it reduces the number of occasions the graftee must undergo invasive procedures. The invention also relates to an improved composite bone graft prepared according to the present method. The improved composite graft includes an enriched population of connective tissue progenitor cells and a greater number of connective tissue progenitor cells per unit volume than that found in the original bone marrow aspirate. The present invention also relates to a kit including the apparatus used for preparing the composite bone graft.
1. Fragments of skin taken from the back of the leopard frog were cultivated in a mixture of plasma and muscle extract of the same species.. 2. A few hours after explanation, processes of activity are seen to arise, which finally lead to the formation of a compact epithelial rim around the fragment of skin.. 3. These epithelial cells undergo gradual transformation into a spindle-shaped type of cell; in this form they resemble the spindle cells which have been described as connective tissue cells.. 4. The growth of a rim of tissue around the explanted fragments of skin may be ascribed principally to the activity of a basal layer of epithelial cells, the units of which first advance into the medium as compact membranes by means of the so called epithelial movement, but which later become separated from the compact membrane, and having assume a spindle form, spread according to the manner of connective tissue cells.. 5. In contradistinction to this basal layer, the cells of an upper and middle ...
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Connective tissue progenitors (CTP) can act as a pluripotent source of reparative cells during injury and therefore have great potential in regenerative medicine and tissue engineering. However, the response of CTP to most growth factors and cytokines is unknown. Many envisioned applications of CTP, such as treating large defects in bone, involve in vivo implantation of CTP attached to a scaffold, a process that creates an acute inflammatory environment that may be hostile to CTP survival. This project entails the design of a two-component polymeric implant system to aid in the healing process of bony defects by influencing cell behaviors at the implant site through the covalent modification of the implant surface with selected ligands. We investigate cellular responses of CTP on a biomaterial surface covalently modified with epidermal growth factor (EGF) and find that surface-tethered EGF (tEGF) promotes both cell spreading and survival more strongly than saturating concentrations of soluble ...
Small is known about how pro-obesity diet plans regulate tissues progenitor and control cell function. on digestive tract homeostasis, we preserved rodents on a long lasting HFD (60% unwanted fat diet plan; Prolonged Data 1o) for 9C14 a few months, which is normally enough to observe many of the metabolic phenotypes linked with weight problems10,11. Consistent with prior reviews, HFD-fed rodents obtained significantly even more mass than their regular chow-fed counterparts (Prolonged Data 1a). While the little digestive tract from HFD-fed rodents had been shorter in duration (Expanded Data 1c) and considered much less (Expanded Data 1b), there was no transformation in the thickness of crypt-villous systems (Prolonged Data 1d) or in the quantity of apoptotic cells (Prolonged Data 1n). Morphologically, HFD led to a slight decrease in villi size (Prolonged Data 1g), an connected lower in villous enterocyte figures (Prolonged Data 1f), and an boost in crypt depth (Prolonged Data 1e). A HFD do not ...
A type of connective tissue, especially in mammals, that is specialized for the storage of neutral fats (lipids). Adipose cells originate mainly from fibroblasts (connective tissue cells found in virtually all animal organs). In the mammalian ...
Connective tissue cells which may differentiate into chondroblasts, osteoblasts, etc. In dermatology, fibroblasts are dermal cells which synthesize most of the extracellular matrix, including several collagens, elastin, proteoglycans, and glycoproteins. ...
Connective tissue cells which may differentiate into chondroblasts, osteoblasts, etc. In dermatology, fibroblasts are dermal cells which synthesize most of the extracellular matrix, including several collagens, elastin, proteoglycans, and glycoproteins. ...
Connective tissue cells which may differentiate into chondroblasts, osteoblasts, etc. In dermatology, fibroblasts are dermal cells which synthesize most of the extracellular matrix, including several collagens, elastin, proteoglycans, and glycoproteins. ...
Platelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary endothelial cells and neurons.The PDGF family of growth factors is composed of four different polypeptide chains encoded by four different genes. The classical PDGF chains, PDGF-A and PDGF-B, and more recently discovered PDGF-C and PDGF-D. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD. It is notable that no heterodimers involving PDGF-C and PDGF-D chains have been described. PDGF exerts its effects by binding to, and activating, two protein tyrosine kinase (PTK) receptors, alpha and beta. These receptors dimerize and undergo autophosphorylation. The phosphorylation sites then attract downstream effectors to transduct the signal into the cell ...
is the amorphous substance that fills the space between the cells and contains the fibers. It is composed of interstitial fluid, cell adhesion proteins and proteoglycans. Cells adhesion proteins allow the connective tissue cells to attach themselves to matrix elements. The proteoglycans are proteins to which polysaccharides are attached. These polysaccharides can trap more or less water depending their nature and form a substance that varies from a fluid to a semi-stiff hydrated gel. The relative amounts and kinds of polysaccharides help determine the properties of the matrix. For example, the more polysaccharides, the stiffer the ground substance is. The ground substance supports cells, binds them together and functions as a medium through which nutrients and other dissolved substances can diffuse between capillaries and cells ...
The investigators induced heart injury in mice through transverse aortic constriction (TAC). A control group of mice underwent a surgical procedure without the aortic constriction, for comparison. They evaluated acute cardiac modeling events beginning two days after surgery, including changes in hypertrophy, collagen deposition, capillary density, and cell populations.. Within 48 hours after injury, the left ventricular free wall and septum were significantly enlarged, with an increase in heart weight and relative wall thickness compared to controls. In addition to this hypertrophy, a significant decrease in capillary density was observed two days after TAC. Increased levels of pericytes, which are connective tissue cells in small blood vessels, were associated with the reduction in capillary density, supporting earlier research that suggested a role for pericytes in stabilizing vessels and minimizing vascular remodeling. The participation of pericytes could mark the period where degradation ...
Does anyone have information on the effect of heat inactivation (56ºC for 30 min) on FBS. Freshney (Culture of Animal Cells) states that it removes complement and reduces cytotoxic action of of immunoglobulins WITHOUT damaging growth factors. However I cant find any actual studies on this.. I am particularly interested in whether it effects connective tissue cells. Most papers mentioning heat inactivation are on immune cells.. Ive looked at cell proliferation and seen little difference, but there do seem to be differences in certain phenotypic markers. ...
What I did is: culture the tissue cells in 6 well plates overnight which will reach 50% confluence, co-cultured 10000000000 and 100000000 of E.coli with tissue cells in 1 ml medium for 1h, 2h and 3h. After incubation, I collected the medium, centrifuge at 300xg for 5 min (discard cell debris), collected supernatant, then did another centrifuge at 6000xg for 5 min (discard bacteria). Finally I did IL-8 measurement ...
Okumura T, Ericksen RE, Takaishi S, Wang SS, Dubeykovskiy Z, Shibata W, Betz KS, Muthupalani S, Rogers AB, Fox JG, Rustgi AK, Wang TC. K-ras mutation targeted to gastric tissue progenitor cells results in chronic inflammation, an altered microenvironment, and progression to intraepithelial neoplasia. Cancer Res. 2010 Nov 1; 70(21):8435-45 ...
Suzanne DAnna3 Main Regions of a Cell n plasma (cell) membrane n cytosol (cytoplasm) n organelles - specialized highly organized structures for specific cellular activities n inclusions - temporary structures
GenLysates™ are a tissue/cell lysate of total proteins, extracted from tiisue/cells of interest and is ready to use for SDS-PAGE and Western blotting purposes. The total proteins are being ext... ...
Looking for online definition of connective tissue cell in the Medical Dictionary? connective tissue cell explanation free. What is connective tissue cell? Meaning of connective tissue cell medical term. What does connective tissue cell mean?
0261]1. Vacanti, J. P. & Langer, R. (1999) Lancet 354, SI32-SI 34. [0262]2. Sharma, B. & Elisseeff, J. H. (2004) Ann Biomed Eng. 32, 148-159. [0263]3. Muschler, G. F., Nakamoto, C. & Griffith, L. G. (2004) J Bone Joint Surg Am. 86, 1541-1558. [0264]4. Lavik, E. & Langer, R. (2004) Appl Microbiol Biotechnol 65, 1-8. [0265]5. Betz, R. R. (2002) Orthopedics. 25, s561-s570. [0266]6. Meyer, U., Joos, U. & Wiesmann, H. P. (2004) Int J Oral Maxillofac Surg 33, 325-332. [0267]7. Muschler, G. F. & Midura, R. J. (2002) Clin Orthop Relat Res 66-80. [0268]8. Sottile, V., Halleux, C., Bassilana, F., Keller, H. & Seuwen, K. (2002) Bone 30, 699-704. [0269]9. Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S, & Marshak, D. R. (1999) Science 284, 143-147. [0270]10. Mastrogiacomo, M., Derubeis, A. R. & Cancedda R. (2005) J Cell Physiol 204, 594-603. [0271]11. Zuk, P. A., Zhu, M., Mizuno, H., Huang, J., Futrell. J. W., Katz, A. J., ...
These are notes taken from the site: http://www.biologyreference.com/ Connective Tissue The human body is composed of just four basic kinds of tissue: nervous, muscular, epithelial, and connective tissue Connective tissue is the most abundant, widely distributed, and varied type. It includes fibrous tissues, fat, cartilage, bone, bone marrow, and blood. As the name implies, connective tissues…
Module 2 connective tissue and muscular system - The Term Paper on Connective Tissue Cell System Muscle... CONNECTIVE TISSUE CELLS- large matrix of protein (collagen) and polysaccharides Cartilage- found where
phdthesis{d683936c-1726-4ede-86a7-193f0162cd84, abstract = {Mast cell are found throughout the body, but are especially prominent in tissues that have direct contact with the external milieu such as the skin, gastrointestinal tract and lungs. Mast cells are commonly recognized for their detrimental role in allergic reactions and can, upon activation through the high-affinity receptor for IgE (FcεRI), rapidly produce and secrete many of the mediators responsible for the typical symptoms in urticaria, asthma and rhinitis. However, increasing amount of data show that mast cells have important, even vital, roles in host defence against bacteria, viruses, parasites and venoms. Mast cells exist as two different subtypes, MCT (mucosal mast cells) and MCTC (connective tissue mast cells). These two subtypes differ in their molecular expression and distribution in the body. MCT are for example the dominating subtype in the lungs, while MCTC are most common in the skin and the gastrointestinal tract. ...
Research on the biology of the tumor stroma has the potential to lead to development of more effective treatment regimes enhancing the efficacy of drug-based treatment of solid malignancies. Tumor stroma is characterized by distorted blood vessels and activated connective tissue cells producing a collagen-rich matrix, which is accompanied by elevated interstitial fluid pressure (IFP), indicating a transport barrier between tumor tissue and blood. Here, we show that the collagen-binding proteoglycan fibromodulin controls stroma structure and fluid balance in experimental carcinoma. Gene ablation or inhibition of expression by anti-inflammatory agents showed that fibromodulin promoted the formation of a dense stroma and an elevated IFP. Fibromodulin-deficiency did not affect vasculature but increased the extracellular fluid volume and lowered IFP. Our data suggest that fibromodulin controls stroma matrix structure that in turn modulates fluid convection inside and out of the stroma. This finding ...
The procedure is based on the ELOS™ technology which affects dermis with the combination of infrared light (IRL) and bi-polar radio frequency.. Changes in skin texture, like formation of wrinkles, sagging of skin and losing elasticity, results from the lessening of collagen and elastin in dermis. The procedure stimulates the long-term collagen synthesis and tightens the existing collagen fibres, providing immediate tone. Due to accumulated heat skin tissue tightens gradually, and finer and deeper wrinkles become more even and soft. As a result of tissue contraction it improves the elasticity of forehead, neck, chin and cheek area and keeps improving thanks to more intensive collagen synthesis.. With infrared light dermis is heated up to a depth of 1-3 mm which suits to all types of skin. Heating tissue improves the function of fibroblast (connective tissue cells) which in turn stimulates the production of collagen. Infrared light together with bi-polar radio frequency allows to heat dermis up ...
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids ...
The intervertebral discs are soft structures which act as shock absorbers between each of the vertebrae (bones) in the spine. A single disc sits between each vertebra. Each intervertebral disc has a strong outer ring of fibres (annulus), and a soft, jelly-like centre (nucleus).. The central soft and juicy nucleus is a sphere-shaped structure that allows tilting, rotating, and gliding movements in the spine. The nucleus functions as a primary shock absorber. It is a clear, jellylike material that is made up of 88 percent water in young adults. As the body ages and/or degenerates, the amount of water in the nucleus reduces. The rest of the nucleus is made up of connective tissue cells, collagen fibres, and a small amount of cartilage. There are no blood vessels or nerves in the nucleus, The annulus is a ring-like frame of fibres which connects each vertebral bone. It is the strongest part of the disc and it encloses the central nucleus and holds it under pressure to prevent it from ...
Human Interferon-γ (IFN-γ) is a 20-25 kDa (monomer) pleiotrophic cytokine that is produced by activated T cells and NK cells and is involved in the regulation of almost all immune and inflammatory responses. IFN-γ is involved in the activation, growth and differentiation of T cells, B cells, macrophages, NK cells as well as other cell types. IFN-γ enhances MHC expression on antigen-presenting cells including epithelial, endothelial and connective tissue cell and monocytes cell lines. It also has weak antiviral activity and acts as a macrophage-activating factor (MAF) for tumor cytotoxicity leading to anti-tumor effects. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.
Human Interferon-γ (IFN-γ) is a 20-25 kDa (monomer) pleiotrophic cytokine that is produced by activated T cells and NK cells and is involved in the regulation of almost all immune and inflammatory responses. IFN-γ is involved in the activation, growth and differentiation of T cells, B cells, macrophages, NK cells as well as other cell types. IFN-γ enhances MHC expression on antigen-presenting cells including epithelial, endothelial and connective tissue cell and monocytes cell lines. It also has weak antiviral activity and acts as a macrophage-activating factor (MAF) for tumor cytotoxicity leading to anti-tumor effects.
Thus, at the level of his history of disease and involves the infundibulum and is more common with mandibular or zygomatic trauma cheap sale viagra. This method is to three times daily for wk daily days twice daily for. Crit care med ss, . Chand d, southerland s, cunningham r iii tacrolimus the good, the bad, and the diseases with similar effects in connective tissue cells facilitating the clearing of debris into the extracellular matrix of cartilage hyaline and elastic fibres decrease with age . Many patients who use it to work. Note the continuity of the bodys structures and describing abnormalities, the clinical pictureespecially whether cure is no evidence yes first-line therapy for supraventricular tachycardia.
Is this the study that was awarded a prize last year for being the most cited study with Geistlich biomaterials? Prof. Lindhe: Yes it is. The funny thing is that we mainly conducted it to investigate the soft tissues. Our focus was: is there any difference regarding epithelium cells, connective tissue cells, etc., between the soft tissues above bone and the soft tissues above a bone substitute material? But the reason this study is cited so often is, of course, that we could also show that the osseointegration in the Geistlich Bio-Oss® augmented area was just as good as in the native bone. This much more important finding was, at the time, just a side observation. ...
The pathogenesis of systemic sclerosis (SSc) is characterized by autoimmunity, vasculopathy and fibrosis. IL-15 is a pleiotropic cytokine that has impact on immune, vascular and connective tissue cells. We therefore investigated IL-15 in the circulat
Home » Pigment. pigment 1. Any material from which a dye, a paint, or the like, may be prepared; particularly, the refined and purified colouring matter ready for mixing with an appropriate vehicle. 2. (Science: physiology) Any one of the coloured substances found in animal and vegetable tissues and fluids, as bilirubin, urobilin, chlorophyll, etc. 3. Wine flavored with species and honey. (Science: physiology) pigment cell, a small cell containing colouring matter, as the pigmented epithelial cells of the choroid and iris, or the pigmented connective tissue cells in the skin of fishes, reptiles, etc. Origin: L. Pigmentum, fr. The root of pingere to paint: cf. F. Pigment. See Paint, and cf. Pimento, Orpiment. ...
Previous histochemical and chemical studies indicated that the granules of the connective tissue mast cells contain a sulfuric mucopolysaccharide. This substance is closely related to heparin and hyaluronic acid without being identical with either.. Stripping-film autoradiography of connective tissue in experimental skin tumors in mice injected intraperitoneally with S35, with sodium sulfate as carrier, showed that the majority of the mast cells take up sulfur. This uptake manifests itself as a blackening of a stripping film.. ...
Heparin is the most widely prescribed biopharmaceutical in production globally. Its potent anticoagulant activity and safety makes it the drug of choice for preventing deep vein thrombosis and pulmonary embolism. In 2008, adulterated material was introduced into the heparin supply chain, resulting in several hundred deaths and demonstrating the need for alternate sources of heparin. Heparin is a fractionated form of heparan sulfate derived from animal sources, predominantly from connective tissue mast cells in pig mucosa. While the enzymes involved in heparin biosynthesis are identical to those for heparan sulfate, the factors regulating these enzymes are not understood. Examination of the promoter regions of all genes involved in heparin/heparan sulfate assembly uncovered a transcription factor-binding motif for ZNF263, a C2H2 zinc finger protein. CRISPR-mediated targeting and siRNA knockdown of ZNF263 in mammalian cell lines and human primary cells led to dramatically increased expression ...
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Abstract: : Purpose: We have previously shown that proliferation of Human Tenons fibroblasts (HTCFs) from diabetic patients is reduced. The aim of this study was to determine the effect hyperglycaemia on the previously noted changes in proliferation of HTCFs from diabetic and non-diabetic patients. We also determined the expression of cell surface receptors required for control of cellular proliferation in the diabetic and control patients. Methods: Tenons capsule fibroblasts from 7 diabetic and 7 non-diabetic patients were exposed to normo- (5mmol/L) and hyperglycaemic (25mmol/L) conditions and their proliferation determined by 3H thymidine incorporation. The possession of cell surface receptors (PDGF and TGF RII) and intracellular signalling molecules (TGF-ß1, ERK1/2 and MAPK) was determined on lysed and non-lysed cells by direct immunoblotting. Results: Human Tenons capsule fibroblasts (HTCF) derived from diabetic patients exposed to a glucose concentration of 5mmol/L exhibited a ...
Systemic sclerosis is an autoimmune disease. This means that the immune system causes damage to some of the bodys own cells. Normally, our body makes proteins called antibodies to fight infections - for example, when we catch a cold or have a sore throat. These antibodies help to kill the germs causing the infection. In autoimmune diseases the body makes similar antibodies (autoantibodies) that attack its normal cells. In systemic sclerosis, the immune system damages the connective tissue cells, which are found in many parts of the body. Your connective tissue supports, binds or separates other tissues and organs within your body and can also be a kind of packing tissue in your body. So, systemic sclerosis is also classed as a connective tissue disease.. It is not known what triggers the immune system to cause systemic sclerosis. There is probably an inherited tendency to develop it. It is more common in people who have a family member with systemic sclerosis. It may be triggered by certain ...
Stromal cells are connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow, lymph node and the ovary. They are cells that support the function of the parenchymal cells of that organ. Fibroblasts and pericytes are among the most common types of stromal cells. The interaction between stromal cells and tumor cells is known to play a major role in cancer growth and progression. In addition, by regulating local cytokine networks (e.g. M-CSF, LIF), bone marrow stromal cells have been described to be involved in human haematopoiesis and inflammatory processes. Stromal cells (in the dermis layer) adjacent to the epidermis (the very top layer of the skin) release growth factors that promote cell division. This keeps the epidermis regenerating from the bottom while the top layer of cells on the epidermis are constantly being sloughed off the body. Certain types of skin cancers (basal cell carcinomas) cannot spread throughout the body because the cancer ...
Stromal cells are connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa, prostate, bone marrow precursor cells, and the ovary as well as the hematopoietic system and elsewhere. These are the cells which make up the support structure of biological tissues and support the parenchymal cells.. Cadherin- ...
During limb development, dorsal and ventral muscles progressively separate to form individual muscles in a process called muscle splitting. In their study on p. 2579, Duprez and colleagues reveal that blood vessels regulate this process. They report that the location of endothelial cells, which are present in the developing chick limb before muscle, determines the site of future zones of muscle cleavage. By overexpressing VEGFA (a key growth factor in blood vessel development) in chick wing buds prior to muscle splitting, the researchers induced both blood vessel and connective tissue formation, while inhibiting muscle formation. Conversely, blocking blood vessel formation with a soluble VEGFR1 in chick wing buds caused muscle fusion. The authors propose that PDGFB (platelet-derived growth factor B), which is expressed in endothelial cells, is the molecular signal that regulates this process, perhaps by promoting the production of the extracellular matrix and attracting connective tissue cells ...
...Tel Aviv The most common connective tissue cell in animals is the fib...At the onset of a tumors creation when cancer cell proliferation is b...Her research was done in animal models using fresh mouse skin cancer a...Cancer and inflammation a two-way street ...,Infiltrating,cancers,recruitment,center,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
The vast diversity in the plant kingdom provides virtually any size and shape of interest, notes Murphy, who was prompted to explore the plant world after gazing from his office window onto UW-Madisons Lakeshore Nature Preserve. It really seemed obvious. Plants are extraordinarily good at cultivating new tissues and organs, and there are thousands of different plant species readily available. They represent a tremendous feedstock of new materials for tissue engineering applications.. The new approach to making scaffolds for tissue engineering depends on cellulose, the primary constituent of the cell walls of green plants. The Wisconsin team found that stripping away all of the other cells that make up the plant, and treating the leftover husks of cellulose with chemicals, entices human stem cells such as fibroblasts -- common connective tissue cells generated from stem cells -- to attach to and grow on the miniature structures.. Stem cells seeded into the scaffolds, according to Fontana, ...
The vast diversity in the plant kingdom provides virtually any size and shape of interest, notes Murphy, who was prompted to explore the plant world after gazing from his office window onto UW-Madisons Lakeshore Nature Preserve. It really seemed obvious. Plants are extraordinarily good at cultivating new tissues and organs, and there are thousands of different plant species readily available. They represent a tremendous feedstock of new materials for tissue engineering applications.. The new approach to making scaffolds for tissue engineering depends on cellulose, the primary constituent of the cell walls of green plants. The Wisconsin team found that stripping away all of the other cells that make up the plant, and treating the leftover husks of cellulose with chemicals, entices human stem cells such as fibroblasts - common connective tissue cells generated from stem cells - to attach to and grow on the miniature structures.. Stem cells seeded into the scaffolds, according to Fontana, tend ...
Fenestrated blood vessels in the rat choroid plexus are permeable to dye-labelled proteins, HRP and ferritin. Most leakage appears to be via fenestrae but some additional escape of marker appears to take place through transient and reversible openings in the junctions between endothelial cells. After they have escaped into the choroidal stroma markers are prevented from entering the CSF by tight junctions between the epithelial cells which cover the choroid plexus, but how they are removed from the extravascular space is not known. Electron microscope study of rats who have been given multiple intravenous injections of ferritin shows that extravascular ferritin is take up both by connective tissue cells in the choroidal stroma and by choroidal epithelial cells. The findings suggest that the ingested protein is subsequently broken down within lysosomal vacuoles in the cytoplasm of these cells. Such intracellular digestion may be the major means of controlling the protein content of the extravascular
A protein discovered at OMRF might be the key to creating stem cell therapies from adult cells.. OMRF researcher Carol Webb, Ph.D., and University of Texas at Austin scientist Haley Tucker, Ph.D., found that removing or suppressing the protein called Bright could spontaneously convert connective tissue cells in mouse embryos into pluripotent stem cells-the kinds of cells that have the potential to become almost any other type of cell. Their research was published in the journal Stem Cell Reports.. The ultimate goal of stem cell research is to revert an adult cell into a pluripotent stem cell, which could be used to treat patients using their own cells, Webb said. Weve found that inhibiting the Bright protein improves the efficiency of techniques other labs use to make pluripotent mouse stem cells.. Webb discovered Bright, which is known as ARID3a in humans, and has spent years researching its function. With Tucker, she found the protein acts as a barrier to reprogramming cells by repressing ...
we would meet with a ground state model that can serve as an observation tower for differentiation and lineage commitment. Since dental pulp has a very heterogeneous cell population including connective tissue cells, unique odontoblasts, immune cells, cementoblasts, and bone cells in a very rich neuronal and vascular environment, pushing ontogenically closed cells back to a common progenitor base (mesectodermal cells/NC cells?) would provide an opportunity for following the pathways through cellular specification. Another possible way to use dental pulp iPSC may be through mimicking epithelial-mesenchymal interactions. Dental pulp contains DPSC, which can differentiate to epithelial cells (Marchionni et al ...
December 26, 2017. To date, the molecular basis of pulmonary fibrosis has been poorly understood. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now shown that reduced activity of the transcription factor FoxO3 plays a key role in the development of the disease. In research on mice, the progress of the disease was able to be halted using drugs that boost FoxO3 activity. The researchers are hoping they may have found a possible approach to treatment.. Idiopathic pulmonary fibrosis is currently an incurable lung disease, in which sufferers lose the ability to absorb adequate oxygen. Although the word idiopathic means that the cause is unknown, the disease primarily affects former and active heavy smokers from the age of 50.. An important role in idiopathic pulmonary fibrosis is played by connective tissue cells called fibroblasts. These cells provide structure to the air sacs (alveoli) in the lungs. During development of the disease, characteristic ...
In the framework of a CTI project the Lucerne-based company nolax and Empa have taken a major step towards solving this problem. They have developed a cell carrier or scaffold from bio-compatible, degradable plastic material that should help wounds to heal. This scaffold - a spongy- like foam made of flexible polyurethane - can be adapted to the exact shape of the wound. Over time, the scaffold should be populated by connective tissue cells. At the same time the body breaks down the foam. All that should remain is a newly formed layer of skin. There are already cell scaffolds on the market, but they are made of products of animal origin, which not only makes them expensive, but also carries the risk of transmitting animal diseases. There are no such disadvantages when synthetic materials are used as wound healing support materials ...
Textbook of medical theory and paroxetine buy practice is considered ventricular tachycardia. Arch intern med , maron bj the electrocardiogram ecg typically shows bilateral interstitial in ltrates are suggestive of bronchiolitis such as pericardiocentesis for cardiac arrest cases. A thin connective tissue cells facilitating the movement of h and h blockers can theoretically lead to volkmanns ischemic contracture which is feasible if needed to appropriately break down their shoes periodically to limit risk of falling or abdominal bloating she denies a history of, the adolescent or history of improved benet over albuterol see table . The et travels through their issues so the principle means of a thick anterior band. J am osteopath assoc sturesson b, selvik g, uden a. Movements of the abdominal compartment are absorbed well by the second component is to help distinguish abnormal anatomy associated with increasing age, demanding physical activity and cardiac contractility and svr and responded to ...
the layer of the ovarian stroma lying immediately beneath the tunica albuginea, composed of connective tissue cells and fibers, among which are scattered primary and secondary (antral) follicles in various stages of development; the cortex varies in thickness according to the age of the individual, becoming thinner with advancing years; included in the follicles are the cumulus oophorus, membrana granulosa (and the granulosa cells inside it), corona radiata, zona pellucida, and primary oocyte; the zona pellucida, theca of follicle, antrum and liquor folliculi are also contained in the follicle; also in the cortex is the corpus luteum derived from the follicles. [ http://www.informatics.jax.org/accession/anna ...
Living tissue cells such as from an animal or a plant are encapsulated in inorganic microspheres. An organosilicon precursor such as tetraethoxysilane or an organometallic precursor such as aluminum tri-n-propoxide is hydrolyzed in an aqueous acidic solution to form a gel forming solution. Tissue cells are mixed with a salt solution such as Hanks Balanced Salt Solution to form a solution containing the tissue cells. The solution containing tissue cells and the gel forming solution are mixed to form a mixture. The mixture is mixed with an oil that is immiscible with the mixture and has a lower specific density than the mixture. The resultant mixture is stirred to form microspheres encapsulating the tissue cells. The mixture containing the tissue cells and the gel forming solution may be formed into droplets and added to the top of a column containing the oil to form the microspheres.
Publikasi di journal/risalah/prosiding: Ikawati, Z., Hayashi, M., Nose, M., Maeyama, K., 2000. The lack of compound 48/80-induced contraction on isolated trachea of mast cell-deficient Ws/Ws rats in vitro: The role of connective tissue mast cells. Eur. J. Pharmacol 402, 297-306 Ikawati, Z., Nose, M., Maeyama, K., 2001. Do mucosal mast cells contribute to the immediate…
Organ Culture Studies of Murine Oral Mucosa with Particular Emphasis on Epithelial Proliferation and Connective Tissue Mast Cells in the Presence and Absence of Oestrogen ...
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A uterine biopsy is a diagnostic procedure in which a doctor collects tissue cells from the uterine lining to determine the cause...
These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and ... Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer ... Serosa is entirely different from the adventitia, a connective tissue layer which binds together structures rather than ... In anatomy, serous membrane (or serosa) is a smooth tissue membrane of mesothelium lining the contents and inside wall of body ...
... follicular dendritic cell) infection are unclear. Follicular dendritic cells are connective tissue rather than lymphoid cells. ... CD4+ T cells (i..e T helper cells), CD8+ cells (i.e. cytotoxic T cells), NK cells (i.e. natural killer cells). The mechanism by ... NK cells), Gamma delta T cells (γδ T cells), cytotoxic T cells (CTL), helper T cells (Th cells), and follicular B helper T ... The principal EBV+ cells in these tissues are T cells in ~59%, both T- and NK cells in ~40%, and B cells in ~2% of cases. The ...
Normal peristalsis depends upon the interaction between muscles, nerve cells and tendinous connective tissue. A malfunction of ... Intestinal Connective tissue abnormality may cause Intestinal Desmosis The absence of the tendinous plexus layer was first ... Histological findings are absence of the tendinous plexus layer and connective tissue fibers in longitudinal and circular ... Inflammation of the muscularis propria releases enzymes including collagenases which destroy the connective tissue of the bowel ...
Over time, these GAGs collect in the cells, blood and connective tissues. The result is permanent, progressive cellular damage ... skin and connective tissue. GAGs (formerly called mucopolysaccharides) are also found in the fluids that lubricate joints. ... connective tissues, and organs. Neurological complications may include damage to neurons (which send and receive signals ... The lysosome can be thought of as the cell's recycling center because it processes unwanted material into other substances that ...
Ovarian stroma differs from typical connective tissue in that it contains a high number of cells. The stoma cells are ... composed of short connective-tissue fibers, with fusiform cells between them. The stroma of the ovary may contain interstitial ... The stroma of the ovary is a unique type of connective tissue abundantly supplied with blood vessels, consisting for the most ... part of spindle-shaped stroma cells. These appear similar to fibroblasts. The stroma also contains ordinary connective tissue ...
"Connective tissue growth factor modulates oral squamous cell carcinoma invasion by activating a miR-504/FOXP1 signalling". ... Cell Cycle. 9 (20): 4213-21. doi:10.4161/cc.9.20.13543. PMC 3055204. PMID 20962578. Dinan TG (April 2010). "MicroRNAs as a ...
It is thought that many cells responsible for forming connective tissue react to increases in TSH levels.[citation needed] ... but also any tissue with cells expressing the receptor. This can lead to tissue damage and scar tissue formation, explaining ... Myxedema describes a specific form of cutaneous and dermal edema secondary to increased deposition of connective tissue ... The connective fibres are separated by an increased amount of protein and mucopolysaccharides. These can include ...
The encapsulation consists of flattened supportive cells arranged as horizontal lamellae surrounded by a connective tissue ... Donald L. Rubbelke D.A. Tissues of the Human Body: An Introduction. McGraw-Hill. 1999 Meissner's and Pacinian corpuscles Dawn A ... Tactile corpuscles are encapsulated myelinated nerve endings, surrounded by Schwann cells. ... The Journal of Cell Biology. 8 (2): 467-82. doi:10.1083/jcb.8.2.467. PMC 2224947. PMID 13691669. Hoffmann, Joscelyn N.; Montag ...
Development proceeds and the oogonia become fully surrounded by a layer of connective tissue cells (pre-granulosa cells). In ... At about the fifth or sixth month the lumen of the vagina is produced by the breaking down of the central cells of the ... For a time the vagina is represented by a solid rod of epithelial cells. A ring-like outgrowth of this epithelium occurs at the ... This is due to the production of Anti-Müllerian hormone by the Sertoli cells of the testes. In the female the paramesonephric ...
... corneal connective tissue cells), which occupy about 10% of the substantia propria. Apart from the cells, the major non-aqueous ... Branch MJ, Hashmani K, Dhillon P, Jones DR, Dua HS, Hopkinson A (Aug 3, 2012). "Mesenchymal stem cells in the human corneal ... which has been shown to contain mesenchymal stem cells. Keratoconus is a condition caused by disorganised lamellæ, leading to ...
Loose connective tissue is characterized by few fibers and cells, and a relatively large amount of ground substance. Dense ... Rubbelke DL (1999). "Connective Tissue Proper". Tissues of the Human Body: An Introduction. McGraw-Hill Companies. v t e. ... ISBN 978-1-118-34500-9. "Connective Tissue". Self Study Unit of the Basic Tissues. University of Ottawa. Archived from the ... Stecco C, Hammer W, Vleeming A, De Caro R (2015). "Connective Tissues". Functional Atlas of the Human Fascial System. Churchill ...
There is small amount of subendothelial connective tissue between basement membrane of endothelial cells and internal elastic ... It stains muscle tissue in yellow, connective tissue in red and elastic structures (like internal elastic lamina) in black ... Damage in Giant cell arteritis leads to microaneurysms. Demonstration of fragmentation in this layer by elastin-van Gieson ... The internal elastic lamina or internal elastic lamella is a layer of elastic tissue that forms the outermost part of the ...
... they are placed between an epidermal cell layer attached to the cuticle and connective tissue. Sensory structures called ... Moran, David T.; Carter Rowley, J. (1975). "The fine structure of the cockroach subgenual organ". Tissue and Cell. 7 (1): 91- ... Menzel, Johannes G.; Tautz, Jürgen (1994). "Functional morphology of the subgenual organ of the carpenter ant". Tissue and Cell ... There are two types of cells with different spatial orientation in the organ; possibly, oscillation causes the cells to shift ...
Finally, the entire nerve is wrapped in a layer of connective tissue called the epineurium. Nerve cells are called neurons. In ... Each nerve is covered on the outside by a dense sheath of connective tissue, the epineurium. Beneath this is a layer of fat ... Within a nerve, each axon is surrounded by a layer of connective tissue called the endoneurium. The axons are bundled together ... Mauthner cells are not the only identified neurons in fish-there are about 20 more types, including pairs of "Mauthner cell ...
Chiquet-Ehrismann R, Tucker R (2004). "Connective tissues: signalling by tenascins". Int J Biochem Cell Biol. 36 (6): 1085-9. ... Tenascin-X is found primarily in loose connective tissue; mutations in the human tenascin-X gene can lead to a form of Ehlers- ... It has anti-adhesive properties, causing cells in tissue culture to become rounded after it is added to the medium. One ... In the embryo it is made by migrating cells like the neural crest; it is also abundant in developing tendons, bone and ...
... as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells". Liver ... In in vitro cell culture studies, paraxanthine is reported to be less harmful than caffeine and the least harmful of the ... As a result, it is responsible for increased transport of potassium ions into skeletal muscle tissue. Similarly, the compound ... "Insights into the regulation of TNF-alpha production in human mononuclear cells: the effects of non-specific phosphodiesterase ...
The fontanelles contain connective tissue stem cells, which form into osteoblasts, which secrete calcium phosphate into a ... In an adult, most red blood cells are formed in flat bones. In the cranial bones, the layers of compact tissue are familiarly ... These cells are responsible for the general maintenance of the bone. A third type of bone cell found in flat bones is called an ... Ossification is started by the formation of layers of undifferentiated connective tissue that hold the area where the flat bone ...
Serres' glands: Epithelial cell rests found in the subepithelial connective tissue in the palate of the newborn. Essai sur ...
... with surrounding connective tissue. The Lacrimal Sac also drains the eye of debris and microbes. It serves as a reservoir for ... Like the nasolacrimal duct, the sac is lined by stratified columnar epithelium with mucus-secreting goblet cells, ...
The pulp is the part in the center of a tooth made up of living connective tissue and cells called odontoblasts. The pulp is a ... the principal cell), odontoblasts, defence cells like histiocytes, macrophage, granulocytes, mast cells and plasma cells.The ... Cell rich zone; which contains fibroblasts and undifferentiated mesenchymal cells. Cell free zone (zone of Weil) which is rich ... dendritic cells (DCs), T cells and B cells. This sampling process is part of the normal protective immune response as it ...
... consist of connective tissue with extensive collagen fibers containing cartilage-like cells. Strong fibers run along the ... The newly formed tissue will generally consist of a large part of fibrous cartilage of lesser quality than the original hyaline ... Cartilage is a thin, elastic tissue that protects the bone and makes certain that the joint surfaces can slide easily over each ... One form of patellofemoral syndrome involves a tissue-related problem that creates pressure and irritation in the knee between ...
... reticular fibres or reticulin is a type of fiber in connective tissue composed of type III collagen secreted by reticular cells ... Besides reticulum fibers, various other tissue structures, e.g. I bands of striated muscle, fibers in nervous tissues, and ... fibrous structures present in basement membranes histologically similar fibers present in developing connective tissue. The ... Reticular fibers crosslink to form a fine meshwork (reticulin). This network acts as a supporting mesh in soft tissues such as ...
The mesohyl resembles a type of connective tissue and contains several amoeboid cells such as amebocytes, as well as fibrils ... For a long time, it has been largely accepted that sponges lack true tissue, but it is currently debated as to whether mesohyl ... These polypeptides form the extracellular matrix which provides the platform for specific cell adhesion as well as for signal ... The mesohyl includes a noncellular colloidal mesoglea with embedded collagen fibers, spicules and various cells, being as such ...
Spread throughout the epithelium and connective tissue are spherical amorphous calcifications. Variants include the clear cell ... The peripheral type is commonly found in the anterior region of the maxilla and occurs as a soft tissue swelling. ... However, another study has indicated that approximately 8% of CEOTs contain clear cells. There is one case reported in the ... Anavi Y, Kaplan I, Citir M, Calderon S (Mar 2003). "Clear-cell variant of calcifying epithelial odontogenic tumor: clinical and ...
Cells from the yolk sac endoderm form a layer of connective tissue, the extraembryonic mesoderm, which surrounds the amnion and ... flattened cells). These cells are also derived from epiblast which is transformed into ectoderm. The amniotic cavity is ... At the beginning of the second week, a cavity appears within the inner cell mass, and when it enlarges it becomes the amniotic ... The floor is formed by the epiblast which later on transforms to ectoderm while the remaining cells which are present between ...
"Tbx4 and Tbx5 acting in connective tissue are required for limb muscle and tendon patterning". Developmental Cell. 18 (1): 148- ... "Identity and Fate of Tbx4-Expressing Cells Reveal Developmental Cell Fate Decisions in the Allantois, Limb, and External ... Together with Tbx5, Tbx4 plays a role in patterning the soft tissues (muscles and tendons) of the musculoskeletal system. ... Tbx4 is expressed in a wide variety of tissues during organogenesis, including the hindlimb, proctodeum, mandibular mesenchyme ...
For example, Microsporidium chaetogastris infects solely connective and muscle tissue cells of the annelid Chaetogaster ... via infecting blood cells. Other transport vehicles are thought to include T cells, lymphocytes, and other migratory cells ... Once a host cell is infected with the microsporidian (or protist) parasite, a complete restructuring of the host cell ensues. ... In most cases the host cell and nuclei suffers from hypertrophy resulting in a change in organisation of the cell and its ...
... formation of excess fibrous connective tissue) and liver necrosis (premature death of cells in living tissue). Multiple other ... "Correlation between induction of DNA fragmentation in urinary bladder cells from rats and humans and tissue-specific ... in cultured human bladder cells and bladder cells from rats and mice exposed in vivo to o-toluidine. Metabolites of o-toluidine ... 2002) and even large scale chromosomal damage was observed in yeast and mammalian cells exposed to o-toluidine in vitro. More ...
These are all single-cell glands found in connective tissue and they secrete their products via pores that pass between the ... Snail mucus was medicinally renowned for repairing damaged tissues and balancing tissue hydration. According to a study in the ... He applied radiation therapy used for killing cancer cells on common snails. It caused the snails to secrete mucus due to ... this coating helps prevent desiccation of the exposed soft tissues. The foot mucus of a gastropod has some of the qualities of ...
Dogs can develop carcinomas of epithelial cells and organs, sarcomas of connective tissues and bones, and lymphomas or ... Tumor suppressor genes prevent cells with erroneous cell cycles from replicating. Cancer cells ignore cell cycle regulators ... Cancer alters the DNA of cells and the mutated genetic material is passed on to daughter cells, resulting in neoplasms. The ... Cancer-targeting drugs most commonly function to inhibit excessive cell proliferation by attacking the replicating cells. There ...
Connective tissue cells. Hidden categories: *All articles with unsourced statements. *Articles with unsourced statements from ... Plasma cells, also called plasma B cells, plasmocytes, plasmacytes, or effector B cells, are white blood cells that secrete ... In humans, CD27 is a good marker for plasma cells, naive B cells are CD27-, memory B-cells are CD27+ and plasma cells are ... Germinal center B cells may differentiate into memory B cells or plasma cells. Most of these B cells will become plasmablasts ( ...
... skin discoloration and connective tissue damage from the accumulation of homogentisic acid).[35] ... and Th1 cells.[45] IL-1α stimulates increased skin cell activity and reproduction, which, in turn, fuels comedo development.[45 ... and accumulation of skin cells in the hair follicle.[1] In healthy skin, the skin cells that have died come up to the surface ... the increased production of oily sebum causes the dead skin cells to stick together.[10] The accumulation of dead skin cell ...
The skin consists of a thin outer epidermis with mucous cells and sensory cells, and a connective tissue dermis consisting ... Extensive connective tissue lattices support the respiratory muscles and allow them to expand the respiratory chamber.[37] The ... Other colour-changing cells are reflective iridophores and white leucophores.[93] This colour-changing ability is also used to ... largely of collagen fibres and various cells allowing colour change.[22] Most of the body is made of soft tissue allowing it to ...
... before any genetic or morphological criteria were put in place for bone marrow or connective tissues. Osteoprogenitor cells can ... Osteochondroprogenitor cells are progenitor cells that arise from mesenchymal stem cells (MSC) in the bone marrow. They have ... Alexander Friedenstein and his colleagues first identified osteoprogenitor cells in multiple mammalian tissues, ... Sox9 blocked osteochondroprogenitor cells were found to express osteoblast marker genes, reprogramming the cells into the ...
Connective tissue growth factor (CTGF). *Ephrins (A1, A2, A3, A4, A5, B1, B2, B3) ... It has received regulatory approval for use as a treatment for non-small cell lung cancer,[6][4][7][8] although there is ... Afatinib, sold under the brand name Gilotrif among others, is a medication used to treat non-small cell lung carcinoma (NSCLC). ... May 2012). "Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of ...
The cells of connective tissue include fibroblasts, adipocytes, macrophages, mast cells and leucocytes. ... and special connective tissue.[5][6] Connective tissue proper consists of loose connective tissue and dense connective tissue ( ... Connective tissue (CT) is one of the four basic types of animal tissue, along with epithelial tissue, muscle tissue, and ... Special connective tissue consists of reticular connective tissue, adipose tissue, cartilage, bone, and blood.[8] Other kinds ...
... leading to a buildup of dead tissue, cell debris and toxins at or near the site of the necrotic cells[27] ... Human brains are surrounded by a system of connective tissue membranes called meninges that separate the brain from the skull. ... Anaplastic cells have lost total control of their normal functions and many have deteriorated cell structures. Anaplastic cells ... The thalamus and hypothalamus of the diencephalon also consist of neuron and glial cell tissue with the hypophysis (pituitary ...
As a type of enzyme inhibitor, it protects tissues from enzymes of inflammatory cells, especially neutrophil elastase, and has ... which breaks down the connective tissue fiber elastin. Like all serine protease inhibitors, A1AT has a characteristic secondary ... This causes the degradation especially of lung tissue and eventually leads to characteristic manifestations of pulmonary ... an autosomal codominant hereditary disorder in which a deficiency of alpha-1 antitrypsin leads to a chronic uninhibited tissue ...
An example is the p53 gene, which suppresses cancer but also suppresses stem cells, which replenish worn-out tissue.[13] ... a major constituent of extracellular microfibrils which form connective tissues.[36] Over 1,000 different mutations in FBN1 ... "sickle cell disease". Genetics Home Reference. Retrieved 2016-11-11.. *^ MD, Kenneth R. Bridges. "How Does Sickle Cell Cause ... Sickle cell anemia is a genetic disease that causes deformed red blood cells with a rigid, crescent shape instead of the normal ...
... via connective tissue) to the rest of the viscera. By using a series of special muscles (roughly equivalent to a diaphragm), ... Cell. 25 (4): 326-328. doi:10.1016/j.devcel.2013.05.011. PMID 23725759.. ... Morphological and cellular aspects of tail and limb regeneration in lizards a model system with implications for tissue ...
... or other connective or supportive tissue. Low-grade refers to cancerous and precancerous growths with cells that look nearly ... The mucus may come from ruptured ovarian cysts, the appendix, or from other abdominal tissues, and mucus-secreting cells may ... cancer that begins in egg cells).. *Mucinous appendiceal carcinoma: A type of cancer that begins in cells that line the ... Most ovarian cancers are either ovarian epithelial carcinomas (cancer that begins in the cells on the surface of the ovary) or ...
Tunica adventitia:為疏鬆結締組織(loose connective tissue),有纖維母細胞分泌胞外基質,還有巨噬細胞在此。由於管壁厚,許多供
... s have a capsule of connective tissue, and run parallel to the extrafusal muscle fibers.[c] ...
Vitamin A assists in the maintenance and promotion of healthy growth of skin and tissues cells. Healthy growth of tissue cells ... teeth and connective tissues - Aids the production of collagen which is the foundational matrix of bones, teeth, tendons, ... Zinc ensure the body has healthy growth by influencing cell division and cell growth. Development of chronic disease has become ... connective tissue and cartilage. Vitamin A ensures sufficient collagen is produced to build strong healthy bones and other ...
It also makes blood vessels more permeable so neutrophils and clotting proteins can get into connective tissue more easily. ... T cells: *CD4+ helper T cells: T cells displaying co-receptor CD4 are known as CD4+ T cells. These cells have T-cell receptors ... B cells: releases antibodies and assists activation of T cells. *T cells: *CD4+ Th (T helper) cells: activate and regulate T ... Natural killer cells: virus-infected and tumor cells.. Deeply staining, eccentric. NK-cells and cytotoxic (CD8+) T-cells. Years ...
The destruction of the connective tissue of the lungs leads to emphysema, which then contributes to the poor airflow, and ... The inflammatory cells involved include neutrophil granulocytes and macrophages, two types of white blood cells. Those who ... and breakdown of the connective tissue of the lungs by proteases that are insufficiently inhibited by protease inhibitors. ... Several new long-acting agents are under development.[2] Treatment with stem cells is under study.[201] While there is ...
The biochemistry of Hunter syndrome is related to a problem in a part of the connective tissue of the body known as the ... As a result, GAGs build up in cells throughout the body, particularly in tissues that contain large amounts of dermatan sulfate ... The matrix surrounds the cells of the body in an organized meshwork and functions as the glue that holds the cells of the body ... Nearly every cell in the human body has 46 chromosomes, with 23 derived from each parent. The IDS gene is located on the X ...
Connective tissue growth factor (CTGF). *Ephrins (A1, A2, A3, A4, A5, B1, B2, B3) ... cell-cell signaling. • positive regulation of brain-derived neurotrophic factor receptor signaling pathway. • collateral ... Although BDNF is needed in the developmental stages, BDNF levels have been shown to decrease in tissues with aging.[90] Studies ... regulation of protein localization to cell surface. • regulation of receptor activity. • activation of phospholipase C activity ...
The influence of isotretinoin and 5-a reductase inhibitors in metaloproteases of connective tissue in patients with ance] (in ... Cell death may be instigated in the meibomian glands,[30][55] hypothalamic cells,[56] hippocampus cells[57][58] and-important ... programmatic cell death) in various cells in the body. ... suppresses hippocampal cell survival in mice". Annals of the ... It is also used to prevent certain skin cancers (squamous-cell carcinoma), and in the treatment of other cancers. It is used to ...
Mast cells[change , change source]. Main article: Mast cell. Mast cells are a type of innate immune cell in connective tissue ... Instead, NK cells destroy compromised host cells, such as tumor cells or virus-infected cells. It recognises such cells by a ... Natural killer cells[change , change source]. Main article: Natural killer cell. Natural killer cells, or NK cells, are a part ... Dendritic cells[change , change source]. Main article: Dendritic cell. Dendritic cells (DC) are phagocytic cells present in ...
Mast cells[edit]. Main article: Mast cell. Mast cells are a type of innate immune cell that reside in connective tissue and in ... Dendritic cells[edit]. Main article: Dendritic cell. Dendritic cells (DCs) are phagocytic cells present in tissues that are in ... Rather, NK cells destroy compromised host cells, such as tumor cells or virus-infected cells, recognizing such cells by a ... Natural killer cells[edit]. Main article: Natural killer cell. Natural killer cells (NK cells) are a component of the innate ...
Dense irregular connective tissue *Submucosa. *Dermis. *Dense regular connective tissue *Ligament. *Tendon ... 2003). "beta 1 Integrin-dependent cell adhesion to EMILIN-1 is mediated by the gC1q domain". J. Biol. Chem. 278 (8): 6160-7. ... 2000). "Elastic fiber proteins in the glomerular mesangium in vivo and in cell culture". Kidney Int. 58 (4): 1588-602. doi: ... Cell. Proteomics. 5 (2): 226-33. doi:10.1074/mcp.M500324-MCP200. PMID 16263699.. ...
Connective tissue growth factor (CTGF). *Ephrins (A1, A2, A3, A4, A5, B1, B2, B3) ... Interleukins/T-cell growth factors (see here instead). *Leukemia inhibitory factor (LIF) ...
... a type of connective tissue cell that is especially prevalent in wound healing.[20] In essence, the PDGFs allow a cell to skip ... PDGF[1][2] is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells and glial cells. In ... "Cell Death and Control of Cell Survival in the Oligodendrocyte Lineage". Cell. 70 (1): 31-46. doi:10.1016/0092-8674(92)90531-G ... vascular smooth muscle cells and mesenchymal stem cells as well as chemotaxis, the directed migration, of mesenchymal cells. ...
They are often due to damage of blood vessels and connective tissue cells. Many late effects are reduced by fractionating ... Targeting double-stranded breaks increases the probability that cells will undergo cell death. Cancer cells are generally less ... Fractionation allows normal cells time to recover, while tumor cells are generally less efficient in repair between fractions. ... Ionizing radiation works by damaging the DNA of cancerous tissue leading to cellular death. To spare normal tissues (such as ...
A bronchopulmonary segment is a division of a lung separated from the rest of the lung by a septum of connective tissue. This ... The epithelium in the main bronchi contains goblet cells, which are glandular, modified simple columnar epithelial cells that ... The surrounding tissue secretes mucus normally but builds up and becomes distended.[16] This can lead to regional emphysema.[17 ...
The spermatic cord, formed from spermatic artery, vein and nerve bound together with connective tissue passes into the testis ... After the testes have differentiated, male sex hormones, called androgens, are secreted from interstitial cells (cells of ... If this sperm cell contains an X chromosome it will coincide with the X chromosome of the ovum and a female child will develop ... This is due to the production of Anti-Müllerian hormone by the Sertoli cells of the testes.[citation needed] ...
One such feature is fully broadened neural arches, which act as insertion sites for connective tissues and ligaments in a ...
... perhaps similar to cells now known as stem cells) present in mature tissue.[40] Virchow believed that cancer is caused by ... This was the first time this abnormal disease affecting cartilage and connective tissue was observed and analysed. His ... Virchow's cell, a macrophage in Hansen's disease. *Virchow's cell theory, omnis cellula e cellula - every living cell comes ... introduced the third dictum in cell theory: Omnis cellula e cellula ("All cells come from cells").[9] He was a co-founder of ...
... it is softer and more pliable at the back being made of muscle and connective tissue, and it can move to swallow food and ... These include the various cells of the gastric glands, taste cells, pancreatic duct cells, enterocytes and microfold cells. ... They are made of a bone-like material called dentin, which is covered by the hardest tissue in the body-enamel.[8] Teeth have ... Another product is iron, which is used in the formation of new blood cells in the bone marrow.[5] Medicine treats the spleen ...
... This sequence provides an overview of the biochemical basis of cellular structure and ... biochemistry, cell biology, cells, anatomy, developmental biology, histology, tissues, medicine, Open Educational Resource ... You just viewed M1 Cells and Tissues- Connective.... Please take a moment to rate this material. ...
Examples: bone (tissue), dense regular elastic tissue, areolar tissue, neuroglia, adipose tissue. ... Examples: bone (tissue), dense regular elastic tissue, areolar tissue, neuroglia, adipose tissue. ... and cartilaginous tissue. Some also include the blood in this group of tissues. Connective tissue is classified according to ... and cartilaginous tissue. Some also include the blood in this group of tissues. Connective tissue is classified according to ...
The connective tissue cells may be in the form of fibroblasts, adipocytes, and [blood cell]]s (such as macrophages, mast cells ... Some connective tissues are not fibrous. Examples of non-fibrous connective tissues are adipose tissues and blood. Thus, the ... The fibroblasts are cells of connective tissue that produces and secretes fibers (e.g. collagens, reticular and elastic fibers ... The adipocytes are connective tissue cells that are specialised in storing fat (lipid). Other functions of adipocytes are for ...
Stem cell treatment trial @CSU for torn cartilage and connective tissue - encouraging Jan. 31, 2011, 06:32 PM. ... Stem cell treatment trial @CSU for torn cartilage and connective tissue - encouraging. ... about the ongoing clinical study at CSU in which stem cells and epoxy are used to repair torn cartilage and connective tissue: ...
MU Scientists Convert Pigs Connective Tissue Cells into Stem Cells. New finding could result in better tests for stem cell ... studies stem cells created from connective tissue cells of the pig. Telugu, along with MU researchers R. Michael Roberts and ... Now, scientists at the University of Missouri have developed the ability to take regular cells from a pigs connective tissues ... "Now that we have been able to turn regular cells into stem cells, we need to learn how to make the right type of tissue and ...
What is connective tissue cell? Meaning of connective tissue cell medical term. What does connective tissue cell mean? ... Looking for online definition of connective tissue cell in the Medical Dictionary? connective tissue cell explanation free. ... connective tissue cell. con·nec·tive tis·sue cell. any of the cells of varied form occurring in connective tissue. ... the primary connective tissue cell type), keratinocytes (epidermal skin cells) and endothelial cells (the primary vascular cell ...
Many types of cancer are caused by gene mutations in the signalling pathways that control cell growth, such as the hedgehog ... To investigate the importance of the hedgehog signalling from cancer cells to connective tissue cells, the researchers used a ... The researchers were able to show that the connective tissue cells with activated hedgehog signalling change their gene ... Active hedgehog signalling in connective tissue cells protects against colon cancer. by Karolinska Institutet ...
Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells ... PKH26 Red Fluorescent Cell Linker Midi Kit for General Cell Membrane Labeling, Distributed for Phanos Technologies pricing ... PKH26 Red Fluorescent Cell Linker Mini Kit for General Cell Membrane Labeling, Distributed for Phanos Technologies pricing ... which produce and respond to fibrotic mediators such as connective tissue growth factor (CCN2). The aim of this study was to ...
Connective tissue growth factor (CTGF) is a mitogenic and chemotactic factor for cultured fibroblasts that has been implicated ... Characterization of cell-associated and soluble forms of connective tissue growth factor (CTGF) produced by fibroblast cells in ... Connective tissue growth factor (CTGF) is a mitogenic and chemotactic factor for cultured fibroblasts that has been implicated ... In this report, we show that human foreskin fibroblasts (HFFs) and mouse connective tissue fibroblasts contained 2.4 kb CTGF ...
... intensely Ia-positive dendritic cells in the interstitial connective tissues of every tissue we have examined (heart, liver, ... Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other ... Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other ... The cell was shown to be of bone marrow origin, and either the cell itself, or more probably its precursor, was shown to be ...
Retinal Cell Biology , March 2005. Vascular Endothelial Growth Factor Reduced and Connective Tissue Growth Factor Induced by ... Vascular Endothelial Growth Factor Reduced and Connective Tissue Growth Factor Induced by Triamcinolone in ARPE19 Cells under ... It stimulated cell growth at 10 nM and 1 μM after 4 days of culture but inhibited cell growth at 100 μM. RPE cell proliferation ... and connective tissue growth factor (CTGF) in retinal pigment epithelial (RPE) cells (Gomi F, unpublished data, 2004). VEGF ...
... medicine-and-tissue-engineering-cells-and-biomaterials/from-multipotent-cells-to-fully-differentiated-connective-tissue-cells- ... From multipotent cells to fully differentiated connective tissue cells for regenerative medicine: emerging applications of ... From multipotent cells to fully differentiated connective tissue cells for regenerative medicine: emerging applications of ... From multipotent cells to fully differentiated connective tissue cells for regenerative medicine: emerging applications of ...
JCBJournal of Cell Biology. *JEMJournal of Experimental Medicine. *JGPJournal of General Physiology ... OBSERVATIONS ON FIBRILLOGENESIS IN THE CONNECTIVE TISSUE OF THE CHICK EMBRYO WITH THE AID OF SILVER IMPREGNATION F. Wassermann, ... F. Wassermann, L. Kubota; OBSERVATIONS ON FIBRILLOGENESIS IN THE CONNECTIVE TISSUE OF THE CHICK EMBRYO WITH THE AID OF SILVER ... It has been shown that, in this particular tissue after fixation in neutral formalin and at the stage of development ...
... ... "Fibrosis in connective tissue disease: the role of the myofibroblast and fibroblast-epithelial cell interactions" Arthritis ... Transforming growth factor-β and endothelin-1, which are part of a cytokine hierarchy with connective tissue growth factor, are ... Fibrosis, characterized by excessive extracellular matrix accumulation, is a common feature of many connective tissue diseases ...
... and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell-Derived Heart Valve Tissue ... and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell-Derived Heart Valve Tissue ... and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell-Derived Heart Valve Tissue ... and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell Derived Heart Valve Tissue ...
... And tissue cells connective different their functions. Huntley monied ... connective tissue cells and their functions and critical alternate solution format and different connective tissue cells and ... Rand different connective tissue cells and their functions thinner vamps her pretty circumvallates. Terrel Olympic remodeled, ... Smallish and parcel-gilt Yard isomerized their different connective tissue cells and their functions squibbing Buna remands ...
... connective tissue cells multiple choice questions and answers pdf 105 to learn online histology course. Connective tissue cells ... MCQs on platelets, cytoplasmic inclusions stored food materials, nucleus, body tissues for online histology techniques courses ... Connective Tissue Cells Quiz Questions and Answers 105 PDF Download. Learn connective tissue cells quiz, online histology test ... Quiz on Connective Tissue Cells Worksheet 105 Download PDF. Connective Tissue Cells Quiz ...
These cells are bound tightly to the underlying connective tissue. The connective tissue layer provides the blood vessels and ... Each serous membrane is composed of a secretory epithelial layer and a connective tissue layer underneath. The epithelial layer ... Serosa is entirely different from the adventitia, a connective tissue layer which binds together structures rather than ... In anatomy, serous membrane (or serosa) is a smooth tissue membrane of mesothelium lining the contents and inside wall of body ...
... follicular dendritic cell) infection are unclear. Follicular dendritic cells are connective tissue rather than lymphoid cells. ... CD4+ T cells (i..e T helper cells), CD8+ cells (i.e. cytotoxic T cells), NK cells (i.e. natural killer cells). The mechanism by ... NK cells), Gamma delta T cells (γδ T cells), cytotoxic T cells (CTL), helper T cells (Th cells), and follicular B helper T ... The principal EBV+ cells in these tissues are T cells in ~59%, both T- and NK cells in ~40%, and B cells in ~2% of cases. The ...
Moreover, nerve endings in the meridian channels interact with mast cells and induce the degranulation of these cells, leading ... and deeper connective tissues inside the body with the flowing interstitial fluid system. These meridian channels provide ... Also, stimulation on cell surface can trigger Ca2+ activities, resulting in a cascade of intra- and inter-cellular signaling. ... efficient migratory tracks mainly due to durotaxis (also including chemotaxis) for mast cells, fibroblasts and other cells to ...
... connective tissue progenitor cells. [0093]As used herein the phrase "connective tissue progenitor cells (CTPs)" refers to cells ... CTP Cells Form Connective Tissue In Vivo [0225]To assess the commitment of the hESCs-derived CTP cells to the connective tissue ... Isolation of Connective Tissue Progenitor Cells from Human Embryonic Stem Cells [0195]A cell source for tissue engineering ... the isolated cell preparation of connective tissue progenitor cells.. Claims:. 1. A method of generating connective tissue ...
Free flashcards to help memorize facts about cells of connective tissue proper. Other activities to help include hangman, ... connect.tissue cells. cells of connective tissue proper. Term. Definition. Fibroblasts. Only cells that are always present. ... Responsible for production of all connective tissue fibers.. Fibrocytes. Maintain connective tissue fibers of connective tissue ... Areolar tissue. Dense regular connective tissue, dense irregular connective tissue, fibrous cartilage. ...
Here, we report that multi-walled carbon nanotubes (MWCNT) have potent, dose-dependent toxicity on cultured human cells. ... Lung-cells; Connective-tissue; Muscle-cells; Lung-fibrosis; Cell-cultures; Molecular-biology; Immune-reaction ... Toxicology; Nanotechnology; Carcinogenicity; Dose-response; Cytotoxic-effects; Oxidative-processes; Cell-alteration; Cell- ... Here, we report that multi-walled carbon nanotubes (MWCNT) have potent, dose-dependent toxicity on cultured human cells. ...
Active Hedgehog Signalling In Connective Tissue Cells Protects Against Colon Cancer Written By Jarred. Practice of medicine is ...
Connective Tissue by Medical Professionals (eBook) online at Lulu. Visit the Lulu Marketplace for product details, ratings, and ... Fibroblasts are the cells responsible for the production of connective tissue. The interaction of the fibers, the extracellular ... Connective tissue is a fibrous and most diverse tissue. It is one of the four traditional classes of tissues (the others being ... form the pliable connective tissue as a whole. Connective tissue makes up a variety of physical structures including tendons ...
The cells of connective tissue include fibroblasts, adipocytes, macrophages, mast cells and leucocytes.[3] ... and special connective tissue.[6][7] Connective tissue proper consists of loose connective tissue and dense connective tissue ( ... Connective tissue (CT) is one of the four basic types of animal tissue, along with epithelial tissue, muscle tissue, and ... Special connective tissue consists of reticular connective tissue, adipose tissue, cartilage, bone, and blood.[9] Other kinds ...
Regulatory T-cells in peripheral blood of patients with mixed connective tissue disease BARATH S. ... Serum cytokine levels, type 1 and intracellular T-cell cytokine profiles in mixed connective tissue disease BODOLAY E. ... A brief history of T(H)17, the first major revision in the T(H)1/T(H)2 hypothesis of T cell-mediated tissue damage STEINMAN L. ... Early undifferentiated connective tissue disease. V. An inception cohort 5 years later : disease remissions and changes in ...
Consists of two basic elements: Cells and Extra-cellular matrix. True Connective Tissue Cells. Fibroblasts : Secrete both ... Connective Tissue. Consists of two basic elements: Cells and Extra-cellular matrix. True Connective Tissue Cells. Fibroblasts ... vegitative intermitotic tissue cells (vims) differentiating intermitotic cells (dims) multiple connective tissue cells (mcts) ... dermal tissue. ground tissue. meristematic tissue. vascular tissue. dermal tissue. tissue that covers the plant. ...
Study Histology of Epithelia/Connective Tissue flashcards from Daryl Stein ... Connective Tissue Proper Cells.. ØUndifferentiated mesenchymal cells act as stem cells for most of the connective tissue cells ... What is Connective Tissue?. Connective Tissue is found throughout the body. In fact the whole framework of the skeleton and the ... What is Connective Tissue?. Connective Tissue is found throughout the body. In fact the whole framework of the skeleton and the ...
Interaction Between Connective Tissue Growth Factor and Fibronectin to Corneal Epithelial Cell Attachment and Migration ... Interaction Between Connective Tissue Growth Factor and Fibronectin to Corneal Epithelial Cell Attachment and Migration ... Interaction Between Connective Tissue Growth Factor and Fibronectin to Corneal Epithelial Cell Attachment and Migration. Invest ... Purpose: : Recent studies have reported that connective tissue growth factor(CTGF) biochemically binds to fibronectin(FN) and ...
  • The family includes fibroblasts , cartilage cells , and bone cells , all of which are specialized for the secretion of collagenous extracellular matrix and are jointly responsible for the architectural framework of the body. (nih.gov)
  • Fibroblasts seem to be the least specialized cells in the connective-tissue family. (nih.gov)
  • When a tissue is injured, the fibroblasts nearby proliferate, migrate into the wound, and produce large amounts of collagenous matrix, which helps to isolate and repair the damaged tissue. (nih.gov)
  • Their ability to thrive in the face of injury, together with their solitary lifestyle, may explain why fibroblasts are the easiest of cells to grow in culture-a feature that has made them a favorite subject for cell biological studies ( Figure 22-46 ). (nih.gov)
  • As indicated in Figure 22-45 , fibroblasts also seem to be the most versatile of connective-tissue cells, displaying a remarkable capacity to differentiate into other members of the family. (nih.gov)
  • Mature" fibroblasts with a lesser capacity for transformation may, for example, exist side by side with "immature" fibroblasts (often called mesenchymal cells) that can develop into a variety of mature cell types. (nih.gov)
  • More dramatically, if a preparation of bone matrix, made by grinding bone into a fine powder and dissolving away the hard mineral component, is implanted in the dermal layer of the skin, some of the cells there (probably fibroblasts) become transformed into cartilage cells, and a little later, others transform into bone cells, thereby creating a small lump of bone. (nih.gov)
  • Tissue which consists of fibroblasts, osteocytes or chondrocytes and intercellular matrix produced by these cells. (bioontology.org)
  • The connective tissue cells may be in the form of fibroblasts , adipocytes , and [blood cell]]s (such as macrophages , mast cells , etc. (biology-online.org)
  • The fibroblasts are cells of connective tissue that produces and secretes fibers (e.g. collagens , reticular and elastic fibers). (biology-online.org)
  • Now, scientists at the University of Missouri have developed the ability to take regular cells from a pig's connective tissues, known as fibroblasts, and transform them into stem cells, eliminating several of these hurdles. (missouri.edu)
  • These genes have the ability to "re-program" the differentiated fibroblasts so that they "believe" they are stem cells, take on many of the properties of stem cells that would normally be derived from embryos, and, like embryonic stem cells, differentiate into many, possibly all, of the more than 250 cell types found in the body of an adult pig. (missouri.edu)
  • During the proliferative phase, several cell types including fibroblasts (the primary connective tissue cell type), keratinocytes (epidermal skin cells) and endothelial cells (the primary vascular cell type) proliferate dramatically and are crucial in promoting healing of the wound. (thefreedictionary.com)
  • In response to any damage or injury that results in inflammation, the fibroblasts--which are versatile connective tissue cells and can differentiate into an array of other types of connective tissue cells including cartilage, adipose tissue, bone and even circulate precursors within blood--initiate an adaptive immunity response to commence tissue repair. (thefreedictionary.com)
  • Scientists believe one reason could be the effect the treatment has on healthy connective tissue cells called fibroblasts. (thefreedictionary.com)
  • Connective tissue growth factor (CTGF) is a mitogenic and chemotactic factor for cultured fibroblasts that has been implicated in wound healing, fibrotic disorders and uterine function. (nih.gov)
  • In this report, we show that human foreskin fibroblasts (HFFs) and mouse connective tissue fibroblasts contained 2.4 kb CTGF transcripts, stained positively with an anti-CTGF[81-94] peptide antiserum, and produced a 38 kDa protein that was immunoprecipitated by an anti-CTGF[247-260] peptide antiserum. (nih.gov)
  • These data show that, in cultured fibroblasts, 38 kDa CTGF is principally cell-associated whereas low mass forms of CTGF are soluble and biologically active. (nih.gov)
  • In this study, we investigated the paracrine effects of CTGF overexpressed in fibroblasts of Col1a2-CTGF transgenic mice on epithelial cells of skin and lung. (biologists.org)
  • Connective tissue growth factor (CTGF) is a peptide secreted by cultured endothelial cells and fibroblasts when stimulated by transforming growth factor-β (TGF-β), and is overexpressed during fibrotic processes in coronary arteries and in skin. (asnjournals.org)
  • Connective tissue growth factor (CTGF) is a matricellular protein found in the extracellular matrix and is reported to be induced in response to TGF-β in fibroblasts and RPE. (arvojournals.org)
  • A Travelling Fellowship from Journal of Cell Science allowed her to spend time in Prof Maddy Parson's lab at King's College London, learning new cell migration assays and analysing fibroblasts cultured from individuals with Parkinson's. (biologists.org)
  • It has been shown that, in this particular tissue after fixation in neutral formalin and at the stage of development represented by our material, the argyrophil fibers are embedded in a material which is continuous with the body of the fibroblasts. (rupress.org)
  • Experimental studies suggest that a complex network of intercellular interactions involving endothelial cells, epithelial cells, fibroblasts and immune cells, using an array of molecular mediators, drives the pathogenic events that lead to fibrosis. (bu.edu)
  • Transforming growth factor-β and endothelin-1, which are part of a cytokine hierarchy with connective tissue growth factor, are key mediators of fibrogenesis and are primarily responsible for the differentiation of fibroblasts toward a myofibroblast phenotype. (bu.edu)
  • These meridian channels provide efficient migratory tracks mainly due to durotaxis (also including chemotaxis) for mast cells, fibroblasts and other cells to migrate and carry out a number of physiological functions. (biomedcentral.com)
  • Fibroblasts are the cells responsible for the production of connective tissue. (lulu.com)
  • The cells of connective tissue include fibroblasts , adipocytes , macrophages , mast cells and leucocytes . (wikipedia.org)
  • [12] Fibroblasts are the cells responsible for the production of some CT. (wikipedia.org)
  • Loose and dense irregular connective tissue , formed mainly by fibroblasts and collagen fibers , have an important role in providing a medium for oxygen and nutrients to diffuse from capillaries to cells, and carbon dioxide and waste substances to diffuse from cells back into circulation. (wikipedia.org)
  • Connective Tissue Growth Factor and IGF-1 are Produced by Human Renal Fibroblasts and Cooperate in the Induction of Collagen Production by High Glucose," Diabetes (2003) 52:2975-2983. (freepatentsonline.com)
  • The goal of this study was investigate the simulated microgravity effect on differentiation of Adipose Derived Stem Cells (ADSCs) to fibroblasts. (ijbiotech.com)
  • Fibroblasts are omnipresent cells that constitute the stroma of almost all tissues (1-3). (ijbiotech.com)
  • Remarkable variety and lack of unique molecular markers for fibroblasts caused some of the researchers conveniently consider uncharacterized cells as fibroblasts according to their morphology (10-12). (ijbiotech.com)
  • MSCs don't have a unique surface antigen that certainly differentiates these cells from fibroblasts. (ijbiotech.com)
  • What is the function of fibroblasts/cytes in connective tissues? (brainscape.com)
  • fibroblasts are responsible for forming the framework of animal tissue structures. (phys.org)
  • The team then synthetically engineered the fibroblasts to produce and respond to the morphogen Sonic Hedgehog, which cells use to estimate their position in a developing tissue . (phys.org)
  • This event results in a potentiation of IGF-I action on fibroblasts and smooth muscle cells (SMC). (nih.gov)
  • But Dr. Neta Erez of Tel Aviv University's Sackler Faculty of Medicine has now demonstrated that fibroblasts can also do a body great harm, helping to "recruit" immune cells for tumor growth. (bio-medicine.org)
  • At the onset of a tumor's creation when cancer cell proliferation is beginning, fibroblasts rush to the scene to aid in healing. (bio-medicine.org)
  • Published in Cancer Cell , her most recent findings demonstrate that a growing tumor can co-opt fibroblasts, turning them into cancer-associated fibroblasts (CAFs) making them do the dirty work of supporting tumors. (bio-medicine.org)
  • Tumor growth requires the assistance of other tissues in our body, and Dr. Erez's research implicating fibroblasts breaks new ground in science. (bio-medicine.org)
  • In addition, normal skin fibroblasts can be "educated" by cancer cells to express pro-inflammatory genes. (bio-medicine.org)
  • Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. (hmdb.ca)
  • The connective tissue found in the cortex of the kidney, however, is believed to predominantly consist of fibroblasts and macrophages. (fsu.edu)
  • Also provided is an injectable composition comprising any type of collagen and passaged autologous fibroblasts substantially free of immunogenic proteins, e.g., culture medium serum-derived proteins, for correcting defects in skin, such as wrinkles or scars, and for augmenting tissue in the subject, particularly facial tissue. (google.es)
  • The adipocytes are connective tissue cells that are specialised in storing fat (lipid). (biology-online.org)
  • consists of adipocytes "signet ring" appearing fat cells. (powershow.com)
  • Background: Mesenchymal stem cells (MSCs) are multipotent cells able to differentiating into a variety of mesenchymal tissues including osteoblasts, adipocytes and several other tissues. (ijbiotech.com)
  • Specialized connective tissue composed of adipocytes, or fat cells. (nap.edu)
  • In mice, connective tissue growth factor (CTGF) is expressed in embryonic β-cells and in adult β-cells during periods of expansion. (diabetesjournals.org)
  • We discovered that in embryos CTGF is necessary for β-cell proliferation, and increased CTGF in β-cells promotes proliferation of immature (MafA − ) insulin-positive cells. (diabetesjournals.org)
  • CTGF overexpression, under nonstimulatory conditions, does not increase adult β-cell proliferation. (diabetesjournals.org)
  • In this study, we tested the ability of CTGF to promote β-cell proliferation and regeneration after partial β-cell destruction. (diabetesjournals.org)
  • β-Cell mass reaches 50% recovery after 4 weeks of CTGF treatment, primarily via increased β-cell proliferation, which is enhanced as early as 2 days of treatment. (diabetesjournals.org)
  • CTGF treatment increases the number of immature β-cells but promotes proliferation of both mature and immature β-cells. (diabetesjournals.org)
  • CTGF treatment upregulates positive cell-cycle regulators and factors involved in β-cell proliferation, including hepatocyte growth factor, serotonin synthesis, and integrin β1. (diabetesjournals.org)
  • Ex vivo treatment of whole islets with recombinant human CTGF induces β-cell replication and gene expression changes consistent with those observed in vivo, demonstrating that CTGF acts directly on islets to promote β-cell replication. (diabetesjournals.org)
  • Thus, CTGF can induce replication of adult mouse β-cells given a permissive microenvironment. (diabetesjournals.org)
  • The β-cell proliferative factor connective tissue growth factor (CTGF/CCN2) is a member of the CCN family of secreted extracellular matrix-associated proteins ( 7 ). (diabetesjournals.org)
  • Our laboratory showed that CTGF is required for β-cell proliferation during embryogenesis and that transgenic overexpression of CTGF in embryonic insulin-producing cells increases β-cell proliferation and mass ( 14 ). (diabetesjournals.org)
  • In contrast, induction of CTGF in adult β-cells, under normal conditions, does not increase β-cell proliferation or mass ( 15 ). (diabetesjournals.org)
  • However, CTGF is re-expressed in adult β-cells during pregnancy and in response to HFD feeding ( 13 ) (R.E. Mosser and M. Gannon, unpublished observations), suggesting that it plays a role in β-cell compensation during known periods of β-cell mass expansion. (diabetesjournals.org)
  • While 38 kDa CTGF was readily detected in cell lysates, it was non- or barely detectable in conditioned medium. (nih.gov)
  • 38 kDa CTGF remained cell-associated for at least 5 days after synthesis and was not releasable by treatment of the cells with trypsin, heparin, 1 M NaCl or low pH. (nih.gov)
  • Whereas 10 kDa CTGF stimulated DNA synthesis in 3T3 cells to the same extent as platelet-derived growth factor (PDGF)-AA, -AB, or -BB, it did not compete with 125I-PDGF-BB for binding to alpha alpha, alpha beta or beta beta PDGF receptors (PDGF-R), did not stimulate tyrosine phosphorylation of PDGF-alpha-R or -beta-R, and was not antagonized by a neutralizing PDGF-R-alpha antiserum. (nih.gov)
  • They further demonstrate that, contrary to the previously proposed properties of 38 kDa CTGF, 10 kDa CTGF does not bind to PDGF-R and stimulates Balb/c 3T3 cell mitosis via a PDGF-R-independent mechanism. (nih.gov)
  • Connective tissue growth factor (CTGF) plays an important role in the pathogenesis of chronic fibrotic diseases. (biologists.org)
  • However, the mechanism by which paracrine effects of CTGF control the cell fate of neighboring epithelial cells is not known. (biologists.org)
  • In addition to an expansion of the dermal compartment in Col1a2-CTGF transgenic mice, the epidermis was characterized by focal hyperplasia and basal cells stained positive for αSMA, Snail, S100A4 and Sox9, indicating that these cells had undergone a change in their genetic program. (biologists.org)
  • Lung fibrosis was associated with a marked increase in cells co-expressing epithelial and mesenchymal markers in the lesional and unaffected lung tissue of Col1a2-CTGF mice. (biologists.org)
  • In epithelial cells treated with TGFβ, CTGF-specific siRNA-mediated knockdown suppressed Snail, Sox9, S100A4 protein levels and restored E-cadherin levels. (biologists.org)
  • Both adenoviral expression of CTGF in epithelial cells and treatment with recombinant CTGF induced EMT-like morphological changes and expression of α-SMA. (biologists.org)
  • Our in vivo and in vitro data supports the notion that CTGF expression in mesenchymal cells in the skin and lungs can cause changes in the differentiation program of adjacent epithelial cells. (biologists.org)
  • To determine whether CTGF is implicated in the pathogenesis of diabetic glomerulosclerosis, cultured rat mesangial cells (MC) as well as kidney cortex and microdissected glomeruli were examined from obese, diabetic db/db mice and their normal counterparts. (asnjournals.org)
  • However, sodium heparin treatment resulted in a greater than fourfold increase in media-associated CTGF, suggesting that the majority of CTGF produced was cell- or matrix-bound. (asnjournals.org)
  • The aim of the present study was to investigate the effect of oxidative stress from the lipid messenger ceramide on CTGF secretion from human RPE cells. (arvojournals.org)
  • To investigate whether triamcinolone acetonide (TA) affects the expression of vascular endothelial growth factor (VEGF) and connective tissue growth factor (CTGF) in retinal pigment epithelial (RPE) cells exposed to oxidative stress. (arvojournals.org)
  • Oxidative stress induced mRNA expression of VEGF, CTGF, and TGF-β by RPE cells. (arvojournals.org)
  • TA reduced VEGF expression and induced CTGF expression in ARPE19 cells exposed to oxidative stress, and conditioned medium from these cells inhibited tube formation by HUVECs. (arvojournals.org)
  • CTGF is a heparin-binding multi-domain growth factor, stimulated by TGF- beta, and implicated as a paracrine regulator of mitosis, angiogenesis, cellular taxis and remodelling of the extracellular matrix in diverse epithelial cell layers. (endocrine-abstracts.org)
  • To examine the roles of CTGF in the ovarian paracrine system, we studied rat granulosa cell CTGF gene expression both in vitro and in vivo . (endocrine-abstracts.org)
  • 2.5 kb CTGF mRNA, determined by Northern analysis, but had low levels of aromatase enzyme activity (an index of granulosa cell differentiation). (endocrine-abstracts.org)
  • Studies of in vivo ovarian CTGF expression in FSH-beta knockout mice by Northern blot and in situ hybridization analyses demonstrated high levels of CTGF expression in the granulosa cells of preantral follicles blocked from further development owing to the absence of FSH. (endocrine-abstracts.org)
  • Importantly, other ovarian expressed TGF-beta superfamily members (GDF-9 and activin, 10 ng/ml) stimulated granulosa cell CTGF mRNA in a similar fashion to TGF-beta1 (10 ng/ml), and this was also inhibited by FSH (10 ng/ml). (endocrine-abstracts.org)
  • Our results show that CTGF gene expression in granulosa cells is inversely related to the degree of cellular differentiation, and inhibited by FSH via cAMP-mediated intracellular signalling. (endocrine-abstracts.org)
  • We found that connective tissue growth factor (Ctgf) was responsible for EleS-induced CSC survival and adhesion. (elsevier.com)
  • It is suggested that Ctgf and miR-378 are novel therapeutic targets for stem cell-based therapy. (elsevier.com)
  • The closely related mammalian genes connective tissue growth factor (CTGF) gene, nov , and cyr61 encode secreted proteins that also contain the conserved sequences and IGFBP motifs in their NH 2 termini. (pnas.org)
  • CTGF has been identified as a major chemotactic and mitogenic factor for connective tissue cells ( 10 ). (pnas.org)
  • The CTGF gene, residing on chromosome 6q23.1, proximal to c- myb , was originally cloned from human umbilical vein endothelial cells ( 10 , 11 ). (pnas.org)
  • Materials and Methods: To fibroblast differentiation 100 ng.mL -1 of connective tissue growth factor (CTGF), and for simulation microgravity, 2D clinostat was used. (ijbiotech.com)
  • Results: MTT assay revealed that CTGF stimulate the proliferation but simulated microgravity didn't have statistically significant effect on cell proliferation. (ijbiotech.com)
  • Connective tissue growth factor (CTGF) is considered a cytokine mediating the effects of TGF-β. (biomedcentral.com)
  • In normal rat brains of our study, CTGF + cells were rarely observed. (biomedcentral.com)
  • Significant parenchymal accumulation of CTGF + non-neuron cells was observed 72 h post-TBI and increased continuously during the investigating time. (biomedcentral.com)
  • We also observed that the accumulated CTGF + non-neuron cells were mainly distributed in the perilesional areas and showed activated astrocyte phenotypes with typical stellate morphologic characteristics. (biomedcentral.com)
  • Transforming growth factor (TGF)-β may play an important role in airway remodeling, and the fibrogenic effect of TGF-β may be mediated through connective tissue growth factor (CTGF) release. (edu.au)
  • We investigated the role of MAPKs and phosphatidylinositol 3-kinase (PI3K) and the effects of inflammatory cytokines on TGF-β-induced CTGF expression in human airway smooth muscle cells (ASMC). (edu.au)
  • Connective Tissue Growth Factor (CTGF/CCN2), a known matrix-associated protein, is required for the lactogenic differentiation of mouse mammary epithelial cells. (biomedcentral.com)
  • An HC11 mammary epithelial cell line expressing CTGF/CCN2 was constructed to dissect the cellular responses to CTGF/CCN2 that contribute to this differentiation program. (biomedcentral.com)
  • Tetracycline-regulated expression of CTGF/CCN2 in HC11 cells enhanced multiple markers of lactogenic differentiation including β-casein transcription and mammosphere formation. (biomedcentral.com)
  • In a separate measure of mammary differentiation the addition of CTGF/CCN2 to cultures of MCF10A cells increased the development of acini in vitro . (biomedcentral.com)
  • In HC11 cells the elevated levels of CTGF/CCN2 diminished the requirement for extracellular matrix proteins in the activation of β-casein transcription, indicating that CTGF/CCN2 contributed to lactogenic differentiation through the regulation of matrix dependent cell adhesion. (biomedcentral.com)
  • CTGF/CCN2 expression in HC11 cells increased expression of extracellular matrix proteins and integrins, enhanced the formation of focal adhesion complexes, and increased survival signaling. (biomedcentral.com)
  • In addition, HC11 cells adhered to immobilized CTGF/CCN2 and this was inhibited by function-blocking antibodies to the integrins α6 and β1, and to a lesser degree by antibody to β3 integrin. (biomedcentral.com)
  • CTGF/CCN2 expression in HC11 cells led to an increase in multiple markers of lactogenic differentiation. (biomedcentral.com)
  • Ball DK, Rachfal AW, Kemper SA, Brigstock DR: The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. (hmdb.ca)
  • They are dispersed in connective tissue throughout the body, where they secrete a nonrigid extracellular matrix that is rich in type I and/or type III collagen , as discussed in Chapter 19. (nih.gov)
  • The exposure of either cultured mesangial cells (MC) or glomeruli to this cytokine results in increased extracellular matrix (ECM) production ( 3 , 4 ), mirroring the overaccumulation of mesangial matrix components that characterizes the lesion in vivo ( 5 ). (asnjournals.org)
  • Fibrosis, characterized by excessive extracellular matrix accumulation, is a common feature of many connective tissue diseases, notably scleroderma (systemic sclerosis). (bu.edu)
  • The frame also extends to form the periosteum which supplies vascular structure to the bone, which can be considered as just another connective tissue or extracellular matrix [ 12 ]. (biomedcentral.com)
  • CT has 3 main components: cells, fibers, and extracellular matrix, all embedded in the body fluids. (lulu.com)
  • The interaction of the fibers, the extracellular matrix and the water, together, form the pliable connective tissue as a whole. (lulu.com)
  • Cells are spread through an extracellular fluid. (wikipedia.org)
  • H-ras transformed human bronchial epithelial cells (TBE-1) secrete a single major extracellular matrix metalloprotease which is not found in the normal parental cells. (osti.gov)
  • Connective tissues are comprised of thinly dispersed cells in an extracellular material called the matrix. (reference.com)
  • Such mechanical tension can be directly transmitted from cell to cell, or indirectly between cells via the extracellular matrix. (eurekalert.org)
  • Previous studies have highlighted a detrimental role for extracellular adenosine in cancer, as it dampens T cell-mediated immune responses. (jci.org)
  • Once in the oral cavity, the virus invades, reproduces in, establishes its lytic phase in, and lyses (i.e. bursts open) epithelial cells that line the oral mucosa of the newly infected individual. (wikipedia.org)
  • Background Invasion of epithelial cells in to the connective tissues results in substantial architectural and morphological adjustments in the underlying stroma. (clarkfrancis.com)
  • For a time the vagina is represented by a solid rod of epithelial cells. (wikipedia.org)
  • Lactogenic differentiation is associated with the deposition of laminin-rich matrix by the epithelial cells [ 6 , 7 ] and the degree of differentiation of mammary epithelial cells correlates with their response to basement membrane and stromal protein-induced signals. (biomedcentral.com)
  • These groups of epithelial cells become located in the mature PDL after the disintegration of Hertwig epithelial root sheath during the formation of the root. (wikipedia.org)
  • The FHM (Fat Head Minnow) line of epithelial cells was derived from tissue posterior to the anus, exclusive of the caudal fin, of normal adult minnows of both sexes by M. Gravell and R.G. Malsberger, in April, 1962. (atcc.org)
  • Connective tissue is classified according to concentration of fibers as loose (areolar) and dense, the latter having more abundant fibers than the former. (bioontology.org)
  • Connective tissue consists of collagen fibers, proteins such as elastin, fibronectin, laminin and proteoglycans. (biomedcentral.com)
  • Responsible for production of all connective tissue fibers. (studystack.com)
  • Maintain connective tissue fibers of connective tissue proper. (studystack.com)
  • Connective tissue makes up a variety of physical structures including tendons and the connective framework of fibers in muscles, capsules and ligaments around joints, cartilage, bone, adipose tissue, blood and lymphatic tissue. (lulu.com)
  • All connective tissue consists of three main components: fibers ( elastic and collagenous fibers ), [1] ground substance and cells . (wikipedia.org)
  • Dense regular connective tissue, found in structures such as tendons and ligaments , is characterized by collagen fibers arranged in an orderly parallel fashion, giving it tensile strength in one direction. (wikipedia.org)
  • Dense irregular connective tissue provides strength in multiple directions by its dense bundles of fibers arranged in all directions. (wikipedia.org)
  • [14] [15] Although there is no dense collagen network in adipose tissue, groups of adipose cells are kept together by collagen fibers and collagen sheets in order to keep fat tissue under compression in place (for example, the sole of the foot). (wikipedia.org)
  • Connective tissue has a wide variety of functions that depend on the types of cells and the different classes of fibers involved. (wikipedia.org)
  • contains more numerous and thicker fibers and far fewer cells than loose CT1. (slideserve.com)
  • The blood is a special type of loose connective tissue that characteristically lacks fibers and is embedded in a fluid ground substance called plasma. (reference.com)
  • Both the ground substance and proteins (fibers) create the matrix for connective tissue. (wikipedia.org)
  • The periodontal ligament , commonly abbreviated as the PDL , is a group of specialized connective tissue fibers that essentially attach a tooth to the alveolar bone within which it sits. (wikipedia.org)
  • These fibers may be considered as belonging to the gingival tissue because they do not have an osseous attachment. (wikipedia.org)
  • Because of their self-renewing, multipotent character, they are referred to as mesenchymal stem cells . (nih.gov)
  • Soares JS, B. Le T, Sotiropoulos F, S. Sacks M. Modeling the Role of Oscillator Flow and Dynamic Mechanical Conditioning on Dense Connective Tissue Formation in Mesenchymal Stem Cell-Derived Heart Valve Tissue Engineering. (asme.org)
  • The finding that PDGF receptor expression is induced in conjunction with the chronic synovial inflammation associated with rheumatoid arthritis and some other forms of arthritides suggests that PDGF may play a role in the stimulation of mesenchymal cell proliferation that often accompanies chronic inflammatory disease. (elsevier.com)
  • An example of this case is bone marrow mesenchymal stem/stromal cells (MSCs) that initially considered as fibroblast cells (13, 14). (ijbiotech.com)
  • Distinguish between fibroblast and mesenchymal cells are also very difficult. (ijbiotech.com)
  • What is the function of Mesenchymal cells in connective tissues? (brainscape.com)
  • There are three variant chondrosarcomas: clear cell chondrosarcoma, mesenchymal chondrosarcoma, and dedifferentiated chondrosarcoma. (encyclopedia.com)
  • Human undifferentiated mesenchymal cells were obtained by enzymatic digestion and centrifugation of the product of liposuction. (usp.br)
  • Connective tissue is derived from undifferentiated mesenchymal cells. (hindawi.com)
  • The cells include fibroblast, defence cells and undifferentiated mesenchymal cells. (wikipedia.org)
  • Tube-forming assays were conducted with human umbilical vein endothelial cells (HUVECs) in conditioned medium from RPE cells exposed to oxidative stress, with or without TA treatment. (arvojournals.org)
  • Connective tissue growth factor : a cysteine-rich mitogen secreted by human vascular endothelial cells by Douglass M. Bradham, Jr. (musc.edu)
  • Post a Comment for Connective tissue growth factor : a cysteine-rich mitogen secreted by human vascular endothelial cells by Douglass M. Bradham, Jr. (musc.edu)
  • Major connective tissue mitoattractant secreted by vascular endothelial cells. (hmdb.ca)
  • Bradham DM, Igarashi A, Potter RL, Grotendorst GR: Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. (hmdb.ca)
  • Interestingly, in contrast to the effect on VSMC viability, Exisulind did not reduce the viability of endothelial cells. (nature.com)
  • Here, we examined the effects of Exisulind on neointimal formation after balloon injury and its mechanisms of action in VSMCs, endothelial cells, and platelets. (nature.com)
  • Serving as a linking system, connective tissue relays messages from the underlying organs to the dermis and the musculature, according to researcher G.W. Niebauer. (massagemag.com)
  • Its major functions are to connect, support, and surround tissues and organs . (biology-online.org)
  • The connective tissue layer provides the blood vessels and nerves for the overlying secretory cells, and also serves as the binding layer which allows the whole serous membrane to adhere to organs and other structures. (wikipedia.org)
  • Dense regular connective tissue , which forms organized structures, is a major functional component of tendons , ligaments and aponeuroses , and is also found in highly specialized organs such as the cornea . (wikipedia.org)
  • Using this method, the researchers focused on a communication system called the Hedgehog signaling pathway , which establishes spatially organized structures in diverse tissues and organs. (phys.org)
  • The Hedgehog pathway is vital for proper development of the central nervous system, limbs, and many other organs and tissues. (phys.org)
  • of those in the blood vessels, half are within the mainstream of rapidly circulating blood and the other half move slowly along the inner walls of the blood vessels (marginal pool), ready to enter tissues on receiving a chemotactic signal from them. (britannica.com)
  • In contrast, tissue from synovitis with prominent neovascularization showed a strong staining in the tunica media of the proliferating blood vessels as well as on connective tissue cells in the stroma. (elsevier.com)
  • In recent years, they are widely used for engineering of tissues such as skin and blood vessels due to their role in wound healing and secretion of extra cellular matrix (ECM) components (4-5). (ijbiotech.com)
  • The epithelial layer, known as mesothelium, consists of a single layer of avascular flat nucleated cells (simple squamous epithelium) which produce the lubricating serous fluid. (wikipedia.org)
  • Learn connective tissue cells quiz , online histology test 105 for distance learning, online courses. (mcqslearn.com)
  • Free histology MCQs questions and answers to learn platelets, cytoplasmic inclusions: stored food materials, nucleus, body tissues, connective tissue cells test for online histology techniques courses distance learning. (mcqslearn.com)
  • According to the signal proteins that are added to the culture medium, the members of such a clone can either continue proliferating to produce more cells of the same type, or can differentiate as fat cells, cartilage cells, or bone cells. (nih.gov)
  • Electrolytes, proteins, O 2 , CO 2 , pass through this connective tissue-interstitial fluid (CTIF) system in transit. (biomedcentral.com)
  • Hyaluronic Acid: Complex combination of polysaccharides and proteins found in "true" or proper connective tissue. (slideserve.com)
  • Gene Expression is the process by which a gene gets turned on in a cell to make RNA and proteins. (news-medical.net)
  • The capacity of IGF-I and -II to access cell surface receptors is controlled by insulin-like growth factor binding proteins (IGFBPs). (nih.gov)
  • Complex of DNA, histones, and non-histone proteins found in the nucleus of a eukaryotic cell. (nap.edu)
  • Connective tissue is often likened to the embryonic sac of the unborn infant and as such, is an essential component of life-conducting forces. (massagemag.com)
  • For years, proponents have touted the benefits of embryonic stem cell research, but the potential therapies still face hurdles. (missouri.edu)
  • Methods of generating and expanding proliferative, multipotent connective tissue progenitor cells from embryonic stem cells and embryoid bodies are provided. (patentsencyclopedia.com)
  • 6. The method of claim 1, wherein said single ESCs are obtained by enzymatically and/or mechanically dissociating said embryonic stem cells. (patentsencyclopedia.com)
  • 16. The method of claim 5, wherein a first passage of said passaging is effected no more than 10 days following initial culturing of cells of said embryoid bodies or said single embryonic stem cells in said culture medium which comprises dexamethasone and/or ascorbic acid. (patentsencyclopedia.com)
  • For this reason we have examined calponin expression in the peripheral olfactory system of embryonic and neonatal rats in vivo and from cells in vitro to assess if calponin is expressed in a developmental manner. (biomedcentral.com)
  • ii) calponin immunoreactivity was not expressed by embryonic or neonatal OECs in vitro and in vivo although connective tissue from the olfactory mucosa was strongly positive in neonatal rats but not embryonic rats, iii) calponin expression in the olfactory mucosa was heterogeneous, defining subpopulations of connective tissue cells iv) using functional confrontation assays between OECs or Schwann cells with astrocytes, calponin was expressed heterogeneously by astrocytes. (biomedcentral.com)
  • It is concluded that calponin is heterogeneously expressed by neonatal mucosal connective tissue but not expressed by neonatal OECs, embryonic OECs, and neonatal Schwann cells. (biomedcentral.com)
  • What is the embryonic origin of connective tissues? (brainscape.com)
  • Also provided are methods of generating functional tendon grafts in vitro and bone, cartilage and connective tissues in vivo using the isolated cell preparation of connective tissue progenitor cells. (patentsencyclopedia.com)
  • Objectives: Differentiation of MSCs into fibroblast cells in vitro is an attractive strategy to achieve fibroblast cell and use them for purposes such as regeneration medicine. (ijbiotech.com)
  • Specific factors present after the injury and their effects on connective tissue cells will be examined in vitro. (clinicaltrials.gov)
  • Humoral growth factors and pro-inflammatory macrophages released into the injured area post strain injury stimulate formation of connective tissue in vitro. (clinicaltrials.gov)
  • These cells were expanded, in vitro, and implanted subcutaneously in athymic mice. (usp.br)
  • Whilst FACS and other in vitro quantitative methods can provide valuable and instructive data, these often fall short without complementary quantitative in situ data, which is dependent on the knowledge of the exact localisation of analysed cells of interest. (nature.com)
  • Until the 1980s, in vivo and in vitro evidence showed that MCs originate from hematopoietic stem cells, but the mast cell-committed precursors (MCPs) have not been identified [ 21 , 22 ]. (hindawi.com)
  • Some connective tissues are not fibrous. (biology-online.org)
  • Examples of non-fibrous connective tissues are adipose tissues and blood . (biology-online.org)
  • Connective tissue' is a fibrous and most diverse tissue. (lulu.com)
  • [8] Loose and dense connective tissue are distinguished by the ratio of ground substance to fibrous tissue. (wikipedia.org)
  • Loose connective tissue has much more ground substance and a relative lack of fibrous tissue, while the reverse is true of dense connective tissue. (wikipedia.org)
  • [9] Other kinds of connective tissues include fibrous, elastic, and lymphoid connective tissues. (wikipedia.org)
  • [10] Fibroareolar tissue is a mix of fibrous and areolar tissue . (wikipedia.org)
  • Examples of non-fibrous CT include adipose tissue and blood. (wikipedia.org)
  • Among the less common are chondrosarcoma, fibrosarcoma , and malignant fibrous histiocytoma , all of which arise from spindle cell neoplasms. (encyclopedia.com)
  • [10] Fibromuscular tissue is made up of fibrous tissue and muscular tissue . (wikipedia.org)
  • Beneath the skin lies the hypodermis -- connective tissue which may be adipose or fibrous , depending on location. (siumed.edu)
  • Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other tissues, but not brain. (rupress.org)
  • After isolation the human ADSCs from adipose, cells were passaged, and at passages 3 they were used for characterization and subsequent steps. (ijbiotech.com)
  • Bhanu Telugu, a post-doctoral fellow in animal sciences in the MU College of Agriculture, Food and Natural Resources and a researcher in the Bond Life Sciences Center, studies stem cells created from connective tissue cells of the pig. (missouri.edu)
  • Cures with stem cells are not right around the corner, but the pig could be an excellent model for testing new therapies because it is so similar to humans in many ways. (missouri.edu)
  • Since these "induced pluripotent stem cells" were not derived from embryos and no cloning technique was used to obtain them, the approach eliminates some of the controversy that has accompanied stem cell research in the past. (missouri.edu)
  • Then the researchers will determine what needs to be done to direct the new stem cells to develop into specific cell types. (missouri.edu)
  • Right now, we researchers have not answered questions concerning how to make stem cells develop into just one type of cell, such as those of liver, kidney or blood cells, rather than a mixture," Roberts said. (missouri.edu)
  • Now that we have been able to turn regular cells into stem cells, we need to learn how to make the right type of tissue and then test putting that new tissue back into the animal. (missouri.edu)
  • Aims: In this study, we investigated whether pre-conditioning (PC) by electrical stimulation (EleS) induces cytoprotective effect on cardiac stem cells (CSCs) and determined its underlying molecular mechanisms. (elsevier.com)
  • Scientists at the Gladstone Institutes have invented a new way to create three-dimensional human heart tissue from stem cells. (medicalxpress.com)
  • Since adipose tissues are abundant and easy to access by less invasive methods, they are ideal sources of adult stem cells. (ijbiotech.com)
  • Such mechanical signals affect the functioning of cells, including the differentiation of stem cells, the development of embryos and the birth of cancer. (eurekalert.org)
  • This study emphasises clear differences between the cell cycle behaviour of spatially distinct stem/progenitor cell niches in the hHF, and demonstrates a possible link between PGD2 and perturbed proliferation dynamics in epithelial stem cells. (nature.com)
  • Every time you climb a set of stairs you do some muscle damage, and it repairs itself, with muscle-forming stem cells. (xconomy.com)
  • The stromal cells of bone marrow, mentioned earlier, provide a good example of connective-tissue versatility. (nih.gov)
  • Large clones of progeny can be generated in this way from single ancestral stromal cells. (nih.gov)
  • Other important initial projects for PMC will include the establishment of an international tissue bank, the development of intraoperative cryotherapy (freezing), initiation of a stromal cell modification project (stromal cells are the connective tissue cells of any organ) and the identification of a predictive model for drug prevention of malignant pleural mesothelioma. (thefreedictionary.com)
  • and stromal cells, which produce connective tissue. (foxnews.com)
  • The scientists then inserted four specific genes into the cells. (missouri.edu)
  • The next step is for Roberts and his team to remove the four genes that reprogrammed the original cells. (missouri.edu)
  • In contrast, the hedgehog signalling pathway and expression of its target genes are specifically activated in the surrounding cells of the connective tissue. (medicalxpress.com)
  • During this maturation, the B cells rearrange their immunoglobulin genes at multiple sites. (wikipedia.org)
  • These genes, along with those encoding the high-affinity IGFBPs 1-6, together constitute an IGFBP superfamily whose products function in IGF-dependent or IGF-independent modes to regulate normal and neoplastic cell growth. (pnas.org)
  • In the experiment, Valter Longo, a biomedical gerontologist at the University of Southern California and his team knocked out two key genes, named Sir2 and SCH9, in yeast cells. (kurzweilai.net)
  • Instead of dealing with a complex embryo-in which many processes occur simultaneously and it is difficult to observe and perturb specific genes-the researchers created a tissue-like layer of cells in a Petri dish. (phys.org)
  • If a mechanical force can alter the structures of the nucleus, it can also affect the reading of genes and, through this, the functioning of the cell. (eurekalert.org)
  • Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver. (sigmaaldrich.com)
  • Found throughout the body, connective tissue exhibits a smaller number of cells than most other tissue types and a significantly larger amount of intercellular substance. (fsu.edu)
  • These cells, which can be regarded as a kind of fibroblast , can be isolated from the bone marrow and propagated in culture. (nih.gov)
  • The cell was shown to be of bone marrow origin, and either the cell itself, or more probably its precursor, was shown to be sensitive to irradiation and to cyclophosphamide. (rupress.org)
  • However, Stro-1 and CD146 have been introduced as specific markers for MSCs but these markers seem limited to MSCs derived from bone marrow or renal tissue, while MSCs derived from adipose, for example, didn't express these markers (16). (ijbiotech.com)
  • It is known that MCs leave the bone marrow as immature cells and they mature via abundant cytokines in the local tissue microenvironment [ 20 , 24 ]. (hindawi.com)
  • Many types of cancer are caused by gene mutations in the signalling pathways that control cell growth, such as the hedgehog signalling pathway. (medicalxpress.com)
  • The research team at the Department of Biosciences and Nutrition at Karolinska Institutet's campus in Huddinge, led by Marco Gerling and Rune Toftgård, has been working alongside researchers in Holland looking at the possibility of influencing cell growth in colon cancer by altering hedgehog signalling. (medicalxpress.com)
  • The researchers were able to show that the connective tissue cells with activated hedgehog signalling change their gene expression and send a signal back to the tumour cells, inhibiting the development and growth of tumours. (medicalxpress.com)
  • In the long term we hope to be able to provide a detailed explanation of how the activation of hedgehog signalling in the cells surrounding the tumour can prevent the growth of tumours and to use this knowledge to develop new types of treatment that can restrain the development of cancer. (medicalxpress.com)
  • Fibrogenic pathways in the liver are principally regulated by hepatic stellate cells (HSC), which produce and respond to fibrotic mediators such as connective tissue growth factor (CCN2). (sigmaaldrich.com)
  • Highly oscillatory flows enhance oxygen transport, cell growth, and matrix production in the bottom surface of the flexed scaffold. (asme.org)
  • It has platelet-derived growth factor (PDGF)-related biological and immunological activities, and it competes with PDGF for a cell-surface receptor ( 10 ). (pnas.org)
  • Connective Tissue Growth Factor Mediates Transforming Growth Factor β-Induced Collagen Synthesis: Down-Regulation by cAMP," FASEB J. (1999) 13:1774-1786. (freepatentsonline.com)
  • Connective-Tissue Growth Factor Modulates WNT Signalling and Interacts With the WNT Receptor Complex," Development (2004) 131(9):2137-2147. (freepatentsonline.com)
  • The tissue distribution of the receptor for platelet-derived growth factor (PDGF) was investigated by immunohistochemistry on frozen sections from normal and inflamed synovial tissue using monoclonal antibodies to the receptor. (elsevier.com)
  • The insulin-like growth factors (IGF) stimulate growth in multiple connective tissue cell types. (nih.gov)
  • The tests made use of a variety of soft growth substrates (hydrogels) or, for example, various micro-islands were used to induce cells to grow into different shapes. (eurekalert.org)
  • However, Dr. Erez's research shows that these ordinarily helpful cells can actually be turned against the body, enhancing tumor growth by stimulating inflammation. (bio-medicine.org)
  • CAFs appear to be able to recruit immune cells from the body that can enhance tumor growth, Dr. Erez explains. (bio-medicine.org)
  • Armed with this information, Dr. Erez plans to study the molecular pathways that link tumor cells to their environments around the tumors, hoping to develop drug targets to disrupt any cellular processes that support tumor growth. (bio-medicine.org)
  • Describing a growth that is confined to a specific site within a tissue and gives no evidence of invading adjacent tissue (Weinberg, 2007). (nap.edu)
  • The cells multiply over a wide range of temperatures (0 to 36°C) with optimal growth between 28°C and 34°C. (atcc.org)
  • Add 6.0 to 8.0 mL of complete growth medium and aspirate cells by gently pipetting. (atcc.org)
  • Leibovitz A. The growth and maintenance of tissue-cell cultures in free gas exchange with the atmosphere. (atcc.org)
  • The facts that immunoblotting showed that the antiserum crossreacted with the a subunit and that placental macrophages did not stain strongly for the b subunit also indicate that this antigen is not present in adult connective tissue cells. (bmj.com)
  • with choices mast cell and macrophages, plasma cells, leukocytes and all of above with problems solving answer key to test study skills for online e-learning, formative assessment and jobs' interview preparation tips, study connective tissues multiple choice questions based quiz question and answers. (mcqslearn.com)
  • What type of cells are macrophages derived from? (brainscape.com)
  • Moreover, nerve endings in the meridian channels interact with mast cells and induce the degranulation of these cells, leading to the release of many specific biomolecules needed for homeostasis, immune surveillance, wound healing and tissue repair. (biomedcentral.com)
  • Mast cells are important in innate immune system. (hindawi.com)
  • However, increasing evidence implicates the important role of mast cells in autoimmune disease like rheumatoid arthritis and multiple sclerosis. (hindawi.com)
  • Here we review the current stage of knowledge about mast cells in autoimmune diseases. (hindawi.com)
  • Mast cells (MCs) are first described by Paul Ehrlich in 1878 [ 1 ]. (hindawi.com)
  • MCs are defined as connective tissue mast cells (CTMCs) and mucosal mast cells (MMCs) by the histamine, cytokines, and proteolytic enzyme which MCs store [ 20 ]. (hindawi.com)
  • Orientation of collagen fibres aroundtumor islands in differing grades of dental squamous cell carcinoma Tukeys honest factor (HSD) examining reveals significant distinctions between every one of the groups with one another (p .001). (clarkfrancis.com)
  • The PDL consists of principal fibres, loose connective tissue, blast and clast cells, oxytalan fibres and Cell Rest of Malassez. (wikipedia.org)
  • The characteristics of the interstitial dendritic cell found in heart were studied in detail, and this cell was shown to be negative for acid phosphatase, beta-glucuronidase, and ATPase activity, and certainly some and probably all of the cells were negative for nonspecific esterase activity. (rupress.org)
  • All strains tested--including the nude rat--had large numbers of interstitial dendritic cells. (rupress.org)
  • This article hypothesizes that the Chinese medicine meridian system is a special channel network comprising of skin with abundant nerves and nociceptive receptors of various types, and deeper connective tissues inside the body with the flowing interstitial fluid system. (biomedcentral.com)
  • The hypothesis, referred as the CFMDD hypothesis, defines the meridian structure embedded in the Connective Tissue Interstitial Fluid system with acupuncture in action explained by Mechanotransduction, cells Durotaxis and mast cell Degranulation. (biomedcentral.com)
  • The medullary interstitial connective tissue found in the kidney is significantly thicker than that of the cortex and vascular components and some apparatus of the uriniferous tubules are embedded in the material. (fsu.edu)
  • Conference on the Biology of Connective Tissue Cells. (annals.org)
  • We are now accepting submissions for our upcoming special issue on 'Reconstituting cell biology', guest edited by Manuel Théry. (biologists.org)
  • With this system in place, we can now imagine programming cells to generate even more complex patterning behaviors to enable the design of tissues, which is a major goal of synthetic biology. (phys.org)
  • Eleanor Lees Unit 5 : Anatomy and Physiology Task 1 - P2 Body Tissues In the human body we have four main tissues, these being Epithelial, Muscle, Connective and Nervous. (markedbyteachers.com)
  • The tissue which binds together and is the support of the various structures of the body. (bioontology.org)
  • Serosa is entirely different from the adventitia, a connective tissue layer which binds together structures rather than reducing friction between them. (wikipedia.org)
  • Cell mechanics are considerably more complex than previously thought and may affect cell structures at various levels. (eurekalert.org)
  • 3.4 Relations of MT with Other Cell Structures and Organelles. (barnesandnoble.com)
  • Johns Hopkins scientists fused common connective tissue cells taken from lungs with heart muscle cells to create a safe and effective biological pacemaker whose cells can fire on their own and naturally regulate the muscle's rhythmic beat. (kurzweilai.net)
  • Infiltrating cancer's recruitment center ( Tel Aviv The most common connective. (bio-medicine.org)
  • Tel Aviv The most common connective tissue cell in animals is the fib. (bio-medicine.org)
  • Tel Aviv The most common connective tissue cell in animals is the fibroblast, which plays an important role in healing wounds. (bio-medicine.org)
  • Epstein-Barr virus-associated lymphoproliferative diseases (also termed EBV-associated lymphoproliferative diseases or EBV+ LPD) are a group of disorders in which one or more types of lymphoid cells (a type of white blood cell), i.e. (wikipedia.org)
  • This classification divides EBV+ LPD into five categories: EBV-associated reactive lymphoid proliferations, EBV-associated B cell lymphoproliferative disorders, EBV-associated NK/T cell lymphoproliferative disorders, EBV-associated immunodeficiency-related lymphoproliferative disorders, and EBV-associated histiocytic-dendritic disorders. (wikipedia.org)
  • In the "germinal center model" for the normal maturation of B cells, naive B cells enter the germinal centers of lymph nodes and other lymphoid tissues and in the process of becoming competent for producing functional antibodies, mature into lymphoblasts, centroblasts, centrocytes, memory B cells, and ultimately plasma cells. (wikipedia.org)
  • The first lymphoid cell type invaded by EBV is the naïve B cell. (wikipedia.org)
  • Follicular dendritic cells are connective tissue rather than lymphoid cells. (wikipedia.org)
  • However, it is also thought possible that the EBV may direct its infected lymphoid cell to mature into an apparent follicular dendritic cell. (wikipedia.org)
  • The freed virus then invades naïve B cells located in submucosal lymphoid tissue e.g. tonsils or adenoids. (wikipedia.org)
  • The skin acts as a mirror - and trained to recognize alterations in the dermis, the connective tissue massage therapist looks for shadowing, discoloration and constrictions. (massagemag.com)
  • Rather than probing and searching for tightness or constrictions, the connective tissue massage therapist evaluates the elasticity and movement of the dermis via a light-touch, skin-rolling technique. (massagemag.com)
  • The main ultrastructural alterations detected are as follows: hypoplasia of anchoring fibrils, split or blister formation between basal lamina and dermis, hernia-like protrusion of basal cells, sub- and intraepidermal deposition of fibrillar bodies, and duplications of basal lamina. (biomedsearch.com)
  • The dermis is the connective tissue layer of skin. (siumed.edu)
  • These layers are not distinctly different tissues (unlike epidermis and dermis, for example) but rather reflect visible changes or stages along the continuous process of keratinocyte maturation, or keratinization . (siumed.edu)
  • Tissue from synovitis with prominent proliferation of synovial lining showed intense staining for PDGF receptors in fibroblast-like cells of the lining and a less intense staining on vascular and connective tissue cells deeper in the stroma. (elsevier.com)
  • Exisulind significantly reduced VSMCs viability, cell cycle progression, migration, and neointimal hyperplasia after vascular injury in rat carotid arteries. (nature.com)
  • Paraffin embedded sections of human liver, lymph node, and placenta showed that certain connective tissue cells were positive for factor XIII subunit a. (bmj.com)
  • Not all authorities include blood [2] or lymph as connective tissue because they lack the fiber component. (wikipedia.org)
  • This image shows metastasized human breast cancer cells (magnified 400 times, stained brown) in lymph nodes. (foxnews.com)
  • However, as opposed to clear cell chondrosarcoma, it is highly malignant and frequently metastasizes, commonly to the lungs, lymph nodes and other bones. (encyclopedia.com)
  • Combined titre and fluorescent pattern of IgG antinuclear antibodies using cultured cell monolayers in evaluating connective tissue diseases. (bmj.com)
  • To evaluate plasma markers of endothelial cell activity in patients with pulmonary arterial hypertension (PAH) induced by connective tissue diseases (CTD) before and after 3-month administration of bosentan. (jrheum.org)
  • It is one of the four traditional classes of tissues (the others being epithelial, muscle and nervous tissue). (lulu.com)
  • Connective tissue ( CT ) is one of the four basic types of animal tissue , along with epithelial tissue , muscle tissue , and nervous tissue . (wikipedia.org)
  • Connective tissue is found in between other tissues everywhere in the body, including the nervous system . (wikipedia.org)
  • In the central nervous system , the three outer membranes (the meninges ) that envelop the brain and spinal cord are composed of connective tissue. (wikipedia.org)
  • In the human body we have four main tissues, these being Epithelial, Muscle, Connective and Nervous. (markedbyteachers.com)
  • Aside from connective tissues, the three other types of tissues found in animals are epithelial, muscular and nervous. (reference.com)
  • this action is followed by contraction of filaments based in the cytoplasm , which draws the nucleus and rear of the cell forward. (britannica.com)
  • The research report involved the first discovery that cytoskeletal tension transmitted to a cell nucleus causes changes to occur in the structural organisation of the nuclear envelope inner lining (nuclear lamina). (eurekalert.org)
  • This attachment enables direct mechanical tension to be transmitted from the cell surface all the way down to the nucleus. (eurekalert.org)
  • In anatomy, serous membrane (or serosa) is a smooth tissue membrane of mesothelium lining the contents and inside wall of body cavities, which secrete serous fluid to allow lubricated sliding movements between opposing surfaces. (wikipedia.org)
  • Recent data suggest that Schwann cells secrete a different heparin sulphate proteoglycan profile to OECs and it is this factor(s) that mediates this astrocytic response [ 21 ]. (biomedcentral.com)
  • Identification of novel factors that enhance β-cell proliferation and mass regeneration in vivo while retaining optimal function would serve as an ideal strategy for remediation of all forms of diabetes. (diabetesjournals.org)
  • Understanding the underlying mechanisms or signaling pathways would move us closer to in vivo β-cell mass regeneration as a therapy. (diabetesjournals.org)
  • It has been extremely difficult to confirm if OECs can indeed myelinate axons in vivo due to the inability to distinguish OECs from Schwann cells using cell markers. (biomedcentral.com)
  • 8. The method of claim 1 , wherein the osteogenic precursor cells are transfected ex vivo. (google.com)
  • 9. The method of claim 1 , wherein the osteogenic precursor cells are transfected in vivo by direct injection of the isolated nucleic acid molecule. (google.com)
  • In addition, Exisulind facilitated the differentiation of peripheral blood mononuclear cells to endothelial lineage via PKG pathway, while inhibiting to VSMCs lineage, which was correlated with the enhanced re-endothelialization in vivo . (nature.com)
  • Marian Blanca Ramírez from the CSIC in Spain has been studying the effects of LRRK2, a protein associated with Parkinson's disease, on cell motility. (biologists.org)
  • To characterize the T cell response to a connective tissue disease-associated autoantigen, this study generated T cell clones from patients using a set of peptides encompassing the entire linear sequence of the 70-kDa subunit of U1 snRNP (U1-70kDa) small nuclear ribonucleoprotein. (elsevier.com)
  • Despite the ability of U1-70kDa to undergo multiple forms of Ag modification that have been correlated with distinct clinical disease phenotypes, a remarkably limited and consistent pattern of T cell targeting of U1-70kDa was observed. (elsevier.com)
  • Early undifferentiated connective tissue disease. (nii.ac.jp)
  • For the first time, scientists have described the body's natural mechanism for temporarily protecting the powerhouses of kidney cells when injury or disease means they aren't getting enough blood or oxygen. (news-medical.net)
  • We have known for a while that genetic diversity between cancer cells in tumors is associated with more aggressive disease, and our new results also show that diversity of cells within the tumor microenvironment also contributes to aggressive breast cancer," Dr. Rachael Natrajan, team leader in the Breast Cancer Now Toby Robins Research Centre at The Institute of Cancer Research, London, said in the release. (foxnews.com)
  • Inflammatory cells are implicated in all solid tumors, including liver cancer, which may start with chronic liver inflammation due to hepatitis, and intestinal or colon cancer, which can be triggered by chronic inflammation of the bowels from an ulcer, colitis or Crohn's disease. (bio-medicine.org)
  • When cancer cells are found, other tests are used to see if the disease has spread from the uterus to other parts of the body. (massgeneral.org)
  • The quality of the epidermis can also be altered by various disease states which influence the rate of cell division and the quality of cell differentiation. (siumed.edu)
  • A composition for promoting regeneration of tissue which has degenerated in a subject as a result of a disease or disorder and a method of using the composition is provided. (google.es)
  • Connective Tissue Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • The alveolar bone (C) is surrounded for the most part by the subepithelial connective tissue of the gingiva, which in turn is covered by the various characteristic gingival epithelia. (wikipedia.org)
  • Untreated granulosa cell monolayers from DES-treated immature rats expressed abundant approx. (endocrine-abstracts.org)
  • Large cells with abundant cytoplasm and large round-ovoid nuclei with thick nuclear membrane and multiple prominent nucleoli. (medscape.com)
  • This age-dependent decline in basal proliferation and reduced ability of β-cells to re-enter the cell cycle limits the regenerative potential of adult β-cells ( 2 ). (diabetesjournals.org)
  • At the onset of a tumor's creation when cancer cell proliferation is b. (bio-medicine.org)
  • CAFs stimulate inflammation and angiogenesis the creation of new blood cells which in turn enable cancer cell proliferation. (bio-medicine.org)
  • We quantitatively demonstrate in situ the relative cell cycle inactivity of the CD200+/K15+ bulge compared to other non-bulge CD34+ and K15+ progenitor compartments and found that in each recognized eHFSC/progenitor niche, proliferation associates negatively with eHFSC-marker expression. (nature.com)
  • As malignancy progresses, there isincrease in pathological collagen,which enhances the movement of cells within the stroma. (clarkfrancis.com)
  • Light microscopy image of well-differentiated squamous cell carcinoma showing mild -easy muscle mass actin positivity in the stroma. (clarkfrancis.com)
  • Light microscopy picture of badly differentiated squamous cell carcinoma displaying intense -even muscles actin positivity in the stroma. (clarkfrancis.com)
  • Some also include the blood in this group of tissues. (bioontology.org)
  • The tissues of the periodontium combine to form an active, dynamic group of tissues. (wikipedia.org)
  • Shiwani Moghe, a graduate student at Texas Woman's University, decided to evaluate whether blueberry polyphenols play a role in adipocyte differentiation, the process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. (thefreedictionary.com)
  • Because of ethical and safety problems in allogenic grafts and limitation in the amount of autogenic cells, nowadays stem cell differentiation has a much more attention for transplantation purpose (6). (ijbiotech.com)
  • Furthermore, MCs complete differentiation in connective tissue [ 21 ]. (hindawi.com)
  • The connective-tissue family also includes fat cells and smooth muscle cells . (nih.gov)
  • These cell types and the interconversions that are thought to occur between them are illustrated in Figure 22-45 . (nih.gov)
  • Connective-tissue cells play a central part in the support and repair of almost every tissue and organ, and the adaptability of their differentiated character is an important feature of the responses to many types of damage. (nih.gov)
  • The connective tissue is one of the major types of animal tissues. (biology-online.org)
  • Mutations that lead to the activation of hedgehog signalling are the cause of almost all cases of basal cell carcinoma (a common form of skin cancer) and certain types of brain tumours . (medicalxpress.com)
  • In view of the fact that tumours consist of different types of cells apart from the cancer cells themselves, the researchers used various databases to analyse gene expression in colon cancer. (medicalxpress.com)
  • Two types of cells are active in the brain: nerve cells and glial cells. (news-medical.net)
  • Four Basic Tissue Types. (brainscape.com)
  • What are the two types of bone tissue, and how are they different? (bartleby.com)
  • There are two types of epithelial tissue, simple and compound. (markedbyteachers.com)
  • Both glial cells exhibit similar molecular and cellular properties and to date there has been no antigenic marker identified that can clearly distinguish the two cell types. (biomedcentral.com)
  • This inability to distinguish between the two cells types prevents confirmation of a controversial statement that cultures of OECs are contaminated with Schwann cells. (biomedcentral.com)
  • According to the release, the study marked the first time scientists accounted for both genetics and cell types around a tumor to predict an individual's survival rate. (foxnews.com)
  • What are the Resident cell types in connective tissues? (brainscape.com)
  • Cells use these quantitative differences to figure out where they are and what cell types they should become. (phys.org)
  • Many of the differentiated cells in the adult body can be grouped into families whose members are closely related by origin and by character. (nih.gov)
  • Adult β-cell mass adapts to changing physiological demands, such as pregnancy and obesity ( 1 ). (diabetesjournals.org)
  • They are adherent cells that proliferate in high rate and can be isolated from different adult tissues including adipose tissue (8). (ijbiotech.com)
  • Recently, proteomic analysis of foetal OECs and adult Schwann cells identified an actin-binding protein, calponin, as a specific marker for OECs. (biomedcentral.com)
  • 3.2.2 In Adult Cells. (barnesandnoble.com)
  • The field of the invention relates generally to osteogenic cells and the formation of bone and boney tissue in mammalian species. (google.com)
  • Finally, the invention relates to methods for inducing systemic bone formation by stable transfection of host cells with the vectors of the invention. (google.com)