Connective Tissue Cells: A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.Connective Tissue: Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.Connective Tissue Diseases: A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Connective Tissue Growth Factor: A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Platelet-Derived Growth Factor: Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Mixed Connective Tissue Disease: A syndrome with overlapping clinical features of systemic lupus erythematosus, scleroderma, polymyositis, and Raynaud's phenomenon. The disease is differentially characterized by high serum titers of antibodies to ribonuclease-sensitive extractable (saline soluble) nuclear antigen and a "speckled" epidermal nuclear staining pattern on direct immunofluorescence.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Granulation Tissue: A vascular connective tissue formed on the surface of a healing wound, ulcer, or inflamed tissue. It consists of new capillaries and an infiltrate containing lymphoid cells, macrophages, and plasma cells.Immediate-Early Proteins: Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.Intercellular Signaling Peptides and Proteins: Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Factor XIII: A fibrin-stabilizing plasma enzyme (TRANSGLUTAMINASES) that is activated by THROMBIN and CALCIUM to form FACTOR XIIIA. It is important for stabilizing the formation of the fibrin polymer (clot) which culminates the coagulation cascade.Factor XIIIa: Activated form of FACTOR XIII, a transglutaminase, which stabilizes the formation of the fibrin polymer (clot) culminating the blood coagulation cascade.Factor XIII Deficiency: A deficiency of blood coagulation FACTOR XIII or fibrin stabilizing factor (FSF) that prevents blood clot formation and results in a clinical hemorrhagic diathesis.Pathology, Clinical: A subspecialty of pathology applied to the solution of clinical problems, especially the use of laboratory methods in clinical diagnosis. (Dorland, 28th ed.)Massage: The systematic and methodical manipulations of body tissues best performed with the hands for the purpose of affecting the nervous and muscular systems and the general circulation.Menu PlanningPalaeognathae: A superorder of large, mostly flightless birds, named for their distinctive PALATE morphology. It includes the orders Apterygiformes, Casuriiformes, Dinornithiformes, RHEIFORMES; STRUTHIONIFORMES and Tinamiformes.Attention Deficit Disorder with Hyperactivity: A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)Holy Roman Empire: Realm in central Europe consisting of a confederation of German and Italian territories under the suzerainty of an emperor and existing from the 9th or 10th century to 1806.Hemorrhagic Fever, American: Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).Microclimate: The climate of a very small area.Chimera: An individual that contains cell populations derived from different zygotes.Endolymphatic Duct: The part of the membranous labyrinth that traverses the bony vestibular aqueduct and emerges through the bone of posterior cranial fossa (CRANIAL FOSSA, POSTERIOR) where it expands into a blind pouch called the endolymphatic sac.Motion Pictures as Topic: The art, technique, or business of producing motion pictures for entertainment, propaganda, or instruction.Dendritic Cells: Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).EsterasesHistocompatibility Antigens Class II: Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.Antigens, CD45: High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Embryonic Stem Cells: Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Tissue Engineering: Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Antigens, CD147: A widely distributed cell surface transmembrane glycoprotein that stimulates the synthesis of MATRIX METALLOPROTEINASES. It is found at high levels on the surface of malignant NEOPLASMS and may play a role as a mediator of malignant cell behavior.Microbial Collagenase: A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.Bronchi: The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Particulate Matter: Particles of any solid substance, generally under 30 microns in size, often noted as PM30. There is special concern with PM1 which can get down to PULMONARY ALVEOLI and induce MACROPHAGE ACTIVATION and PHAGOCYTOSIS leading to FOREIGN BODY REACTION and LUNG DISEASES.Apolipoproteins E: A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.Vehicle Emissions: Gases, fumes, vapors, and odors escaping from the cylinders of a gasoline or diesel internal-combustion engine. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Random House Unabridged Dictionary, 2d ed)Air Pollution: The presence of contaminants or pollutant substances in the air (AIR POLLUTANTS) that interfere with human health or welfare, or produce other harmful environmental effects. The substances may include GASES; PARTICULATE MATTER; or volatile ORGANIC CHEMICALS.Air Pollutants: Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or material. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Nitric Oxide Synthase Type II: A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.

Insulin regulation of amino acid transport in mesenchymal cells from avian and mammalian tissues. (1/275)

Insulin regulation of amino acid transport across the cell membrane was studied in a variety of mesenchymal cell directly isolated from avian and mammalian tissues or collected from confluent cultures. Transport activity of the principal systems of mediation in the presence and absence of insulin was evaluated by measuring the uptake of representative amino acids under conditions approaching initial entry rates. Insulin enhanced the transport rate of substrate amino acids from the A system(alpha-aminoisobutyric acid, L-proline, glycine, L-alanine and L-serine) in fibroblasts and osteoblasts from chick-embryo tissues, in mesenchymal cells (fibroblasts and smooth muscle cells) from immature rat uterus, in thymic lymphocytes from young rats and in chick-embryo fibroblasts from confluent secondary cultures. In these tissues, the uptake of amino acid substrates of transport systems L and Ly+ (L-leucine, L-phenylalanine, L-lysine) was not affected by the presence of the hormone. No insulin control of amino acid transport was detected in chick-embryo chondroblasts and rat peritoneal macrophages. These observations identify the occurrence of hormonal regulatory patterns of amino acid transport for different mesenchymal cells types and indicate that these properties emerge early during cell differentiation.  (+info)

Role of matrix metalloproteinases and their tissue inhibitors in the regulation of coronary cell migration. (2/275)

The migration of vascular cells is regulated by matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). Because the activation of adventitial fibroblasts has been implicated in coronary repair, we have examined regional differences in cell outgrowth and the synthesis of MMPs/TIMPs in different layers of porcine coronary arteries. Coronary medial explants demonstrated significantly slower cell outgrowth than coronary adventitia in culture (P<0.001). These observations were paralleled by the predominant expression of TIMP-1 and -2 in the media (14-fold and 37-fold higher than in adventitia, respectively, P<0.001), whereas higher gelatinolytic activities (MMP-2 and -9) were released from adventitial explants. Smooth muscle cell outgrowth from the media was regulated by endogenous TIMPs, since TIMP inhibition (recombinant MMP-2 or neutralizing anti-TIMP antibodies) facilitated cell outgrowth (P<0.001). In contrast, the addition of recombinant TIMP-1 or -2 decreased adventitial cell outgrowth. In the coculture experiments, the presence of coronary media retarded adventitial cell outgrowth, whereas medial damage abrogated these effects, allowing for fibroblast migration (P<0.001). In conclusion, this study demonstrated differential migratory properties and distinct MMP/TIMP synthesis by coronary fibroblasts and smooth muscle cells. Endogenous TIMPs in the media may play an important role in maintaining coronary arterial wall homeostasis, whereas high levels of matrix-degrading activities confer the "invasive" characteristics of adventitial fibroblasts.  (+info)

Selective antibody blockade of lymphocyte migration to mucosal sites and mast cell adhesion. (3/275)

The integrins alpha4beta7 and alpha4beta1 mediate adhesion to the mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and the vascular cell adhesion molecule-1 (VCAM-1) and are important in T cell and allergic inflammatory reactions in the rat. The relative contributions of alpha4beta7 and alpha4beta1 in these reactions is unknown. To examine the role of alpha4beta7 in the rat a new mAb, TA-6, was developed. TA-6 inhibited adhesion to MAdCAM-1 but not to VCAM-1, a characteristic of alpha4beta7 adhesion, and immunofluorescence and immunoprecipitation studies were compatible with binding to alpha4beta7. TA-6 blocked rat lymphocyte adhesion to mesenteric lymph nodes and T cell migration to mucosal lymphoid tissues and it bound to rat mucosal mast cells. TA-6 did not inhibit lymphocyte adhesion to peripheral lymph nodes and T cell migration to peripheral lymphoid tissues or cutaneous inflammatory sites, and was not expressed on connective tissue mast cells.  (+info)

Gi-mediated activation of mitogen-activated protein kinase (MAPK) pathway by receptor mimetic basic secretagogues of connective tissue-type mast cells: bifurcation of arachidonic acid-induced release upstream of MAPK. (4/275)

The family of basic secretagogues of connective tissue mast cells act as receptor mimetic agents, which trigger exocytosis by directly activating G proteins. We now demonstrate that pertussis toxin (Ptx)-sensitive Gi proteins, activated by compound 48/80 (c48/80), a potent member of this family, also activate the p42/p44 MAP kinases (MAPKs). This activation was potentiated by the protein tyrosine phosphatase inhibitor vanadate, whereas the tyrphostin AG-18, a competitive inhibitor of protein tyrosine kinases (PTKs); the protein kinase C inhibitors K252a and GF109203X; the phosphatidylinositol-3-kinase (PI-3K) inhibitors wortmannin and LY294002; and EGTA have abolished this activation. These results suggest that c48/80 activated the p42/p44 MAPKs via a mechanism that involves PTKs, protein kinase C, phosphatidylinositol-3-kinase and Ca2+ as mediators. Protein tyrosine phosphorylation and activation of the p42/p44 MAPKs were closely correlated with stimulation of arachidonic acid (AA) release by c48/80 but not with histamine secretion. However, whereas PD98059, the inhibitor of the MAPK kinase has abrogated MAPK activation, this inhibitor failed to effect release of AA. We therefore conclude that by activating Ptx-sensitive Gi protein(s), the basic secretagogues of mast cells stimulate multiple signaling pathways, which diverge to regulate the production and release of the different inflammatory mediators. Whereas the signaling pathway responsible for triggering histamine release is PTK independent, the pathway responsible for the stimulation of AA release bifurcates downstream to PTKs but upstream to the activation of MAPKs.  (+info)

Cyclic expression of mRNA transcripts for connective tissue components in the mouse ovary. (5/275)

In the ovary, differentiation of germinal cells into primordial follicles, functional ovulatory follicles and corpus luteum, all take place in a connective tissue matrix. We postulated that extracellular matrix (ECM) of the ovary participates actively in ovarian functions. To test this, the mRNA levels for several ECM components were determined in the mouse ovary at six distinct stages of the 4-day oestrous cycle. Northern analysis revealed statistically significant cyclic expression patterns for the mRNAs coding for type III, IV and VI collagens as well as for the small proteoglycan, biglycan, and for syndecan-1 and osteonectin. The cyclic changes observed in the mRNAs for these structural components exceeded those for matrix metalloproteinases (MMP)-2, -9 and -13, and for tissue inhibitors of matrix metalloproteinases (TIMP)-1, -2 and -3, where the changes were not statistically significant, despite their apparent role in ECM remodelling in the ovary. These observations support the hypothesis that cyclic changes in the production and degradation of ECM are part of normal ovarian function connected with follicular maturation, rupture and corpus luteum formation.  (+info)

Distribution of membrane cofactor protein (MCP/CD46) on pig tissues. Relevance To xenotransplantation. (6/275)

Membrane cofactor protein (MCP; CD46) is a 50-60 000 MW glycoprotein, expressed on a wide variety of cells and tissues in man, which plays an important role in regulating complement activation. Human MCP has also been shown to be the receptor for measles virus. We have recently identified the pig analogue of MCP and demonstrated that pig MCP has cofactor activity for factor I-mediated cleavage of C3b when these components are derived either from pig or human. As a consequence, pig MCP is an efficient regulator of the classic and alternative pathways of human and pig complement. In order to define the potential importance of MCP in protecting against complement activation in the pig, we have conducted a comprehensive survey of its distribution in pig cells and organs. As in humans, MCP in the pig is broadly and abundantly distributed. Pig MCP is highly expressed on all circulating cells, including erythrocytes, in contrast to its absence on human erythrocytes. Multiple isoforms of MCP are found on cells and in tissues, probably representing products of alternative splicing analogous to those found in man. MCP is abundantly expressed throughout all tissues examined with particularly strong staining on the vascular endothelium. Connective tissue elements within liver and testis are also strongly stained by anti-pig MCP antibodies. Pig MCP is expressed only weakly on skeletal muscle cells and expression is absent from smooth muscle cells in the lung and vessel walls, sites at which human MCP is expressed. Of particular note, MCP is not expressed in B-cell areas of the germinal centres of lymph nodes.  (+info)

Increased incidence of apoptosis in non-labour-affected cytotrophoblast cells in term fetal membranes overlying the cervix. (7/275)

A regional reduction in the cellularity of the cytotrophoblastic and decidual layers occurs in the fetal membranes overlying the cervix in the lower uterine segment prior to labour. Although the mechanism(s) involved are not known it could result from regionally increased apoptosis, the histological manifestation of programmed cell death, or decreased proliferation. Apoptosis was assessed in regionally sampled fetal membranes from women undergoing elective Caesarean section (n = 14) by the presence of apoptotic bodies by light and electron microscopy. Cell proliferation was assessed by immunocytochemical detection of the protein Ki-67. Apoptotic bodies were identified in all regions of the fetal membrane with the highest incidence found within the cytotrophoblast layer. However, this layer in fetal membranes biopsied over the cervix contained significantly more apoptotic bodies (mean +/- SD 0.085 +/- 0.020%) compared to the layer in fetal membranes obtained from the mid-zone (0.020 +/- 0.008%) apoptotic bodies. Isolated Ki-67 positive cells were detected in the cytotrophoblast layer, but no regional differences in their incidence were seen. Fetal membranes also failed to exhibit significant immunoreactivity for BCL-2 but exhibited strong BAX immunoreactivity within the decidual layer. We conclude that the regionally increased incidence of apoptosis in the cytotrophoblastic layer in the membrane overlying the cervix may account for the reduction in its cellularity but not the relative decrease in the decidual layer. Given the consequence of the loss of local function in degrading uterotonins and stabilizing the fetal membrane, the study of the regulation of apoptosis in these cells may have important implications for fetal membrane rupture and parturition.  (+info)

Lipopolysaccharide-activated macrophages stimulate the synthesis of collagen type I and C-fibronectin in cultured pancreatic stellate cells. (8/275)

We have recently identified and characterized pancreatic stellate cells (PSC) in rats and humans (Gastroenterology 1998, 15:421-435). PSC are suggested to represent the main cellular source of extracellular matrix in chronic pancreatitis. Now we describe a paracrine stimulatory loop between human macrophages and PSC (rat and human) that results in an increased extracellular matrix synthesis. Native and transiently acidified supernatants of cultured macrophages were added to cultured PSC in the presence of 0.1% fetal calf serum. Native supernatants of lipopolysaccharide-activated macrophages stimulated the synthesis of collagen type I 1.38 +/- 0.09-fold of control and c-fibronectin 1.89 +/- 0.18-fold of control. Transiently acidified supernatants stimulated collagen type I and c-fibronectin 2.10 +/- 0.2-fold and 2.80 +/- 0.05-fold of control, respectively. Northern blot demonstrated an increased expression of the collagen-I-(alpha-1)-mRNA and fibronectin-mRNA in PSC 10 hours after addition of the acidified macrophage supernatants. Cell proliferation measured by bromodeoxyuridine incorporation was not influenced by the macrophage supernatants. Unstimulated macrophages released 1.97 pg TGFbeta1/microgram of DNA over 24 hours and lipopolysaccharide-activated macrophages released 6.61pg TGFbeta1/microgram of DNA over 24 hours. These data together with the results that, in particular, transiently acidified macrophage supernatants increased matrix synthesis, identify TGFbeta as the responsible mediator. In conclusion, our data demonstrate a paracrine stimulation of matrix synthesis of pancreatic stellate cells via TGFbeta1 released by activated macrophages. We suggest that macrophages might play a pivotal role in the development of pancreas fibrosis.  (+info)

*Radiation therapy

They are often due to damage of blood vessels and connective tissue cells. Many late effects are reduced by fractionating ... Targeting double-stranded breaks increases the probability that cells will undergo cell death. Cancer cells are generally less ... Fractionation allows normal cells time to recover, while tumor cells are generally less efficient in repair between fractions. ... Single-strand DNA damage is then passed on through cell division; damage to the cancer cells' DNA accumulates, causing them to ...

*Karl Joseph Eberth

"Eberth's perithelium": an incomplete layer of connective tissue cells encasing the blood capillaries. Untersuchungen über ... "Eberth's lines": Microscopic lines that appear between the cells of the myocardium when stained with silver nitrate. " ...

*Dermal fibroblast

2002). "Fibroblasts and Their Transformations: The Connective-Tissue Cell Family". Molecular Biology of the Cell (4th ed.). New ... The Connective-Tissue Cell Family". Microbiology of the Cell (4th ed.). New York: Garland Science. Hinz, Boris; Phan, Sem H.; ... Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and ... Although dermal cells demonstrate less plasticity than other fibroblast cell types, researchers can still turn these cells into ...

*Decidualization

ESCs are the connective tissue cells of the endometrium that are fibroblastic in appearance. However, decidualization causes ... Outside of their immune functions, the uNK cells and dendritic cells also act as regulators of maternal spiral artery ... cells and some dendritic cells. As the fetus consists of both maternal and paternal DNA, the decidual leukocytes play a role in ... Lash, G.E.; Robson, S.C.; Bulmer, J.N. "Review: Functional role of uterine natural killer (uNK) cells in human early pregnancy ...

*Wandering cell

... plasma cells, eosinophils and mast cells are wandering cells. Fibrocytes are the most common cell type in connective tissues. ... "resting wandering cells". Connective tissue cells are typically divided into two types, fixed cells and wandering cells. ... Adipocytes are fat cells that are fixed cells in loose connective tissue. Their main function is the storage of lipid. ... Reticular cells are usually larger than fibrocytes. Reticular cells are the fibrocytes of reticular connective tissue and form ...

*Milky spots

Other structural elements are plasmocytes and various connective tissue cells including reticular and elastic fibres. There is ... The milky spots are made up of mesenchymal cells and are covered in a layer of mesothelium. These structures surround the small ... Milky spots are very small white-coloured areas of lymphoid tissue, found in the peritoneal, pleural and pericardial cavities. ... The enclosing mesothelium contains macrophages, lymphocytes and mast cells. They are also known as secondary lymphoid organs. ...

*Mesoblastic nephroma

... connective tissue cells). Histologic examination of these tumors provides critical information on their prognoses. This ... Its tissues show interlaced spindle-shaped smooth muscle cells evidencing low mitotic activity with no evidence of tumor ... Its tissues show densely packed fibrosarcoma-like cells evidencing high rates of mitosis, less infiltration of normal kidney ... Clear cell sarcoma of the kidney, which is responsible for 5-10% of childhood pediatric tumors, occurs predominantly in ...

*Fibrocyte

Fibroblasts are activated connective tissue cells characterized by synthesis of proteins of the fibrous matrix, particularly ... These cells have been reported to express the hematopoietic cell surface markers CD34+, CD45+, as well as collagen. These cells ... When tissue is injured, the predominant mesenchymal cells, the fibroblast, have been believed to be derived from the fibrocyte ... A fibrocyte is an inactive mesenchymal cell, that is, a cell showing minimal cytoplasm, limited amounts of rough endoplasmic ...

*Stroma of cornea

... corneal connective tissue cells), which occupy about 10% of the substantia propria. Apart from the cells, the major non-aqueous ... Branch MJ, Hashmani K, Dhillon P, Jones DR, Dua HS, Hopkinson A (Aug 3, 2012). "Mesenchymal stem cells in the human corneal ... which has been shown to contain mesenchymal stem cells. Keratoconus is a condition caused by disorganised lamellæ, leading to ...

*Peter Medawar

Medawar's first scientific research was on the effect of malt on the development of connective tissue cells (mesenchyme) in ... cells gradually acquire the ability to distinguish between their own tissue substances on the one hand and unwanted cells and ... They extracted cells from young mouse embryos and injected them into another mouse of different strains. When the mouse ... "Peter Brian Medawar". Cell. Immunol. 62 (2): 235-42. August 1981. doi:10.1016/0008-8749(81)90319-1. PMID 7026052. Lawrence, H ...

*Stroma (tissue)

Stromal tissue is primarily made of extracellular matrix containing connective tissue cells. Extracellular matrix is primarily ... Stromal connective tissues are found in the stroma; this tissue belongs to the group connective tissue proper. The function of ... immune system blood cells causing inflammatory response. Fixed cells - cells that are permanent inhabitants of the tissue. ... The cells which make up stroma tissues serve as a matrix in which the other cells are embedded. Stroma is made of various types ...

*Amoeboid movement

... as well as some cells in humans such as leukocytes. Sarcomas, or cancers arising from connective tissue cells, are particularly ... March 2011). "Cell physician: reading cell motion. A mathematical diagnostic technique through analysis of single cell motion ... As long as the cell has a way to grapple the substratum, repetition of this process guides the cell forward. Inside the amoeba ... Blebbing occurs in amoeboid cells when there is a roughly spherical protrusion in the cell membrane characterized by ...

*Development of the digestive system

Hematopoietic cells (present in the liver in greater numbers before birth than afterward), Kupffer cells, and connective tissue ... Connective tissue, muscular components, and peritoneal components originate in the mesoderm. Different regions of the gut tube ... By the fifth week, the connecting tissue bridge has narrowed, and the caudal part of the foregut, the midgut, and a major part ... Since the septum transversum is located initially opposite cervical segments of three to five, and since muscle cells for the ...

*Stromal cell

Stromal cells are connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow ... They are cells that support the function of the parenchymal cells of that organ. Fibroblasts and pericytes are among the most ... Stroma is made up of the non-malignant cells, but can provide an extracellular matrix on which tumor cells can grow. Stroma ( ... The interaction between stromal cells and tumor cells is known to play a major role in cancer growth and progression. In ...

*Herbert McLean Evans

On the Differential Reaction to Vital Dyes Exhibited by the Two Groups of Connective-tissue Cells. Carnegie Institution of ...

*Katharine Bishop

Herbert Mclean On the differential reactions to vital dyes exhibited by the two great groups of connective-tissue cells. ...

*Axel Höjer

Hojer in the early 1920s researched on vitamin C and its role in connective tissue cell maturation. He submitted his thesis in ...

*Harold M. Weintraub

... connective tissue cells) into myoblasts (skeletal muscle cells). Later studies by the same group of investigators at FHCRC ... I. Cell cycle kinetics and control of cell division". J Cell Biol. 50 (3): 652-668. doi:10.1083/jcb.50.3.652. Weintraub, H; ... The effects of bromodeoxyuridine on cell differentiation (conversion of a primitive cell into a more specialized cell) were ... Zhuang, Y; Soriano, P; Weintraub, H (1994). "The helix-loop-helix gene E2A is required for B cell formation". Cell. 79 (5): 875 ...

*Platelet-derived growth factor

... a type of connective tissue cell that is especially prevalent in wound healing. In essence, the PDGFs allow a cell to skip the ... vascular smooth muscle cells and mesenchymal stem cells as well as chemotaxis, the directed migration, of mesenchymal cells. ... PDGF is a potent mitogen for cells of mesenchymal origin, including fibroblasts, smooth muscle cells and glial cells. In both ... "Cell Death and Control of Cell Survival in the Oligodendrocyte Lineage". Cell. 70 (1): 31-46. doi:10.1016/0092-8674(92)90531-G ...

*Cochlea

... while the connective-tissue gap-junction network couples connective-tissue cells. Gap-junction channels recycle potassium ions ... For one, the tall hair cell is very similar in function to that of the inner hair cell, and the short hair cell, lacking ... Three rows consist of outer hair cells (OHCs) and one row consists of inner hair cells (IHCs). The inner hair cells provide the ... In birds, for instance, instead of outer and inner hair cells, there are tall and short hair cells. There are several ...

*Ali Mobasheri

From Multipotent Cells to Fully Differentiated Connective Tissue Cells for Regenerative Medicine: Emerging Applications of ... In: Regenerative Medicine and Tissue Engineering: Cells and Biomaterials (2011) Three-Dimensional, High-Density and Tissue ... In: Mechanosensitive Ion Channels (2008) Applications of tissue microarrays in renal physiology and pathology. In: Renal and ... Putative roles in mechanotransduction, metabolic regulation and cell proliferation. ...

*Development of the reproductive system

Development proceeds and the oogonia become fully surrounded by a layer of connective tissue cells (pre-granulosa cells) In ... At about the fifth or sixth month the lumen of the vagina is produced by the breaking down of the central cells of the ... For a time the vagina is represented by a solid rod of epithelial cells. A ring-like outgrowth of this epithelium occurs at the ... This is due to the production of Anti-Müllerian hormone by the Sertoli cells of the testes. In the female the paramesonephric ...

*Leigh disease

... connective tissue cells) and skeletal muscle. Kidney and heart tissues were found to not have a COX deficiency. French Canadian ... This causes a chronic lack of energy in the cells, which leads to cell death and in turn, affects the central nervous system ... The heart and other muscles also require a lot of energy and are affected by cell death caused by chronic energy deficiencies ... The deficiency was found to be almost complete in brain and liver tissues and substantial (approximately 50% of normal enzyme ...

*Kidney tumour

... connective tissue cells) detected prenatally or, more typically, during the first ... Some renal cell carcinomas are hypovascular and not distinguishable with Doppler US. Therefore, renal tumors without a Doppler ... The most common malignant renal parenchymal tumor is renal cell carcinoma (RCC), which accounts for 86% of the malignancies in ... There are many forms of kidney tumours: The most frequent, malignant, primary kidney cancer is renal cell carcinoma (RCC) - ...

*Development of the gonads

Development proceeds and the oogonia become fully surrounded by a layer of connective tissue cells (pre-granulosa cells) in an ... Development proceeds and the oogonia become fully surrounded by a layer of connective tissue cells (pre-granulosa cells) In ... hypothesized that in sheep most of the granulosa cells develop from cells of the mesothelium (i.e., epithelial cells from the ... Between the cells of the germinal epithelium a number of larger cells, the immature ova, are found. The immature ova, in turn, ...

*Paratenonitis

Peritendinous tissues become macroscopically thickened and new connective tissue adhesions occur. In paratenonitis, ... It is presented with acute edema and hyperaemia of the paratenon with infiltration of inflammatory cells. After few hours or ... inflammatory cells are found in the cellular elements of the paratenon and in the vascular ingrowth. Maffulli, Nicola; Wong, ...
The present invention provides a new and improved method for preparing a composite bone graft. The method includes providing a bone marrow aspirate suspension and passing the bone marrow aspirate suspension through a porous, biocompatible, implantable substrate to provide a composite bone graft having an enriched population of connective tissue progenitor cells. Because the method is preferably performed intraoperatively it reduces the number of occasions the graftee must undergo invasive procedures. The invention also relates to an improved composite bone graft prepared according to the present method. The improved composite graft includes an enriched population of connective tissue progenitor cells and a greater number of connective tissue progenitor cells per unit volume than that found in the original bone marrow aspirate. The present invention also relates to a kit including the apparatus used for preparing the composite bone graft.
1. Fragments of skin taken from the back of the leopard frog were cultivated in a mixture of plasma and muscle extract of the same species.. 2. A few hours after explanation, processes of activity are seen to arise, which finally lead to the formation of a compact epithelial rim around the fragment of skin.. 3. These epithelial cells undergo gradual transformation into a spindle-shaped type of cell; in this form they resemble the spindle cells which have been described as connective tissue cells.. 4. The growth of a rim of tissue around the explanted fragments of skin may be ascribed principally to the activity of a basal layer of epithelial cells, the units of which first advance into the medium as compact membranes by means of the so called epithelial movement, but which later become separated from the compact membrane, and having assume a spindle form, spread according to the manner of connective tissue cells.. 5. In contradistinction to this basal layer, the cells of an upper and middle ...
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Connective tissue progenitors (CTP) can act as a pluripotent source of reparative cells during injury and therefore have great potential in regenerative medicine and tissue engineering. However, the response of CTP to most growth factors and cytokines is unknown. Many envisioned applications of CTP, such as treating large defects in bone, involve in vivo implantation of CTP attached to a scaffold, a process that creates an acute inflammatory environment that may be hostile to CTP survival. This project entails the design of a two-component polymeric implant system to aid in the healing process of bony defects by influencing cell behaviors at the implant site through the covalent modification of the implant surface with selected ligands. We investigate cellular responses of CTP on a biomaterial surface covalently modified with epidermal growth factor (EGF) and find that surface-tethered EGF (tEGF) promotes both cell spreading and survival more strongly than saturating concentrations of soluble ...
Small is known about how pro-obesity diet plans regulate tissues progenitor and control cell function. on digestive tract homeostasis, we preserved rodents on a long lasting HFD (60% unwanted fat diet plan; Prolonged Data 1o) for 9C14 a few months, which is normally enough to observe many of the metabolic phenotypes linked with weight problems10,11. Consistent with prior reviews, HFD-fed rodents obtained significantly even more mass than their regular chow-fed counterparts (Prolonged Data 1a). While the little digestive tract from HFD-fed rodents had been shorter in duration (Expanded Data 1c) and considered much less (Expanded Data 1b), there was no transformation in the thickness of crypt-villous systems (Prolonged Data 1d) or in the quantity of apoptotic cells (Prolonged Data 1n). Morphologically, HFD led to a slight decrease in villi size (Prolonged Data 1g), an connected lower in villous enterocyte figures (Prolonged Data 1f), and an boost in crypt depth (Prolonged Data 1e). A HFD do not ...
A type of connective tissue, especially in mammals, that is specialized for the storage of neutral fats (lipids). Adipose cells originate mainly from fibroblasts (connective tissue cells found in virtually all animal organs). In the mammalian ...
Connective tissue cells which may differentiate into chondroblasts, osteoblasts, etc. In dermatology, fibroblasts are dermal cells which synthesize most of the extracellular matrix, including several collagens, elastin, proteoglycans, and glycoproteins. ...
Connective tissue cells which may differentiate into chondroblasts, osteoblasts, etc. In dermatology, fibroblasts are dermal cells which synthesize most of the extracellular matrix, including several collagens, elastin, proteoglycans, and glycoproteins. ...
Platelet-derived Growth Factor (PDGF) is a potent stimulator of growth and motility of connective tissue cells such as fibroblasts and smooth muscle cells as well as other cells such as capillary endothelial cells and neurons.The PDGF family of growth factors is composed of four different polypeptide chains encoded by four different genes. The classical PDGF chains, PDGF-A and PDGF-B, and more recently discovered PDGF-C and PDGF-D. The four PDGF chains assemble into disulphide-bonded dimers via homo- or heterodimerization, and five different dimeric isoforms have been described so far; PDGF-AA, PDGF-AB, PDGF-BB, PDGF-CC and PDGF-DD. It is notable that no heterodimers involving PDGF-C and PDGF-D chains have been described. PDGF exerts its effects by binding to, and activating, two protein tyrosine kinase (PTK) receptors, alpha and beta. These receptors dimerize and undergo autophosphorylation. The phosphorylation sites then attract downstream effectors to transduct the signal into the cell ...
is the amorphous substance that fills the space between the cells and contains the fibers. It is composed of interstitial fluid, cell adhesion proteins and proteoglycans. Cells adhesion proteins allow the connective tissue cells to attach themselves to matrix elements. The proteoglycans are proteins to which polysaccharides are attached. These polysaccharides can trap more or less water depending their nature and form a substance that varies from a fluid to a semi-stiff hydrated gel. The relative amounts and kinds of polysaccharides help determine the properties of the matrix. For example, the more polysaccharides, the stiffer the ground substance is. The ground substance supports cells, binds them together and functions as a medium through which nutrients and other dissolved substances can diffuse between capillaries and cells ...
The investigators induced heart injury in mice through transverse aortic constriction (TAC). A control group of mice underwent a surgical procedure without the aortic constriction, for comparison. They evaluated acute cardiac modeling events beginning two days after surgery, including changes in hypertrophy, collagen deposition, capillary density, and cell populations.. Within 48 hours after injury, the left ventricular free wall and septum were significantly enlarged, with an increase in heart weight and relative wall thickness compared to controls. In addition to this hypertrophy, a significant decrease in capillary density was observed two days after TAC. Increased levels of pericytes, which are connective tissue cells in small blood vessels, were associated with the reduction in capillary density, supporting earlier research that suggested a role for pericytes in stabilizing vessels and minimizing vascular remodeling. "The participation of pericytes could mark the period where degradation ...
Does anyone have information on the effect of heat inactivation (56ºC for 30 min) on FBS. Freshney (Culture of Animal Cells) states that it removes complement and reduces cytotoxic action of of immunoglobulins WITHOUT damaging growth factors. However I cant find any actual studies on this.. I am particularly interested in whether it effects connective tissue cells. Most papers mentioning heat inactivation are on immune cells.. Ive looked at cell proliferation and seen little difference, but there do seem to be differences in certain phenotypic markers. ...
What I did is: culture the tissue cells in 6 well plates overnight which will reach 50% confluence, co-cultured 10000000000 and 100000000 of E.coli with tissue cells in 1 ml medium for 1h, 2h and 3h. After incubation, I collected the medium, centrifuge at 300xg for 5 min (discard cell debris), collected supernatant, then did another centrifuge at 6000xg for 5 min (discard bacteria). Finally I did IL-8 measurement ...
Suzanne DAnna3 Main Regions of a Cell n plasma (cell) membrane n cytosol (cytoplasm) n organelles - specialized highly organized structures for specific cellular activities n inclusions - temporary structures
GenLysates™ are a tissue/cell lysate of total proteins, extracted from tiisue/cells of interest and is ready to use for SDS-PAGE and Western blotting purposes. The total proteins are being ext... ...
Looking for online definition of connective tissue cell in the Medical Dictionary? connective tissue cell explanation free. What is connective tissue cell? Meaning of connective tissue cell medical term. What does connective tissue cell mean?
0261]1. Vacanti, J. P. & Langer, R. (1999) Lancet 354, SI32-SI 34. [0262]2. Sharma, B. & Elisseeff, J. H. (2004) Ann Biomed Eng. 32, 148-159. [0263]3. Muschler, G. F., Nakamoto, C. & Griffith, L. G. (2004) J Bone Joint Surg Am. 86, 1541-1558. [0264]4. Lavik, E. & Langer, R. (2004) Appl Microbiol Biotechnol 65, 1-8. [0265]5. Betz, R. R. (2002) Orthopedics. 25, s561-s570. [0266]6. Meyer, U., Joos, U. & Wiesmann, H. P. (2004) Int J Oral Maxillofac Surg 33, 325-332. [0267]7. Muschler, G. F. & Midura, R. J. (2002) Clin Orthop Relat Res 66-80. [0268]8. Sottile, V., Halleux, C., Bassilana, F., Keller, H. & Seuwen, K. (2002) Bone 30, 699-704. [0269]9. Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S, & Marshak, D. R. (1999) Science 284, 143-147. [0270]10. Mastrogiacomo, M., Derubeis, A. R. & Cancedda R. (2005) J Cell Physiol 204, 594-603. [0271]11. Zuk, P. A., Zhu, M., Mizuno, H., Huang, J., Futrell. J. W., Katz, A. J., ...
These are notes taken from the site: http://www.biologyreference.com/ Connective Tissue The human body is composed of just four basic kinds of tissue: nervous, muscular, epithelial, and connective tissue Connective tissue is the most abundant, widely distributed, and varied type. It includes fibrous tissues, fat, cartilage, bone, bone marrow, and blood. As the name implies, connective tissues…
phdthesis{d683936c-1726-4ede-86a7-193f0162cd84, abstract = {Mast cell are found throughout the body, but are especially prominent in tissues that have direct contact with the external milieu such as the skin, gastrointestinal tract and lungs. Mast cells are commonly recognized for their detrimental role in allergic reactions and can, upon activation through the high-affinity receptor for IgE (FcεRI), rapidly produce and secrete many of the mediators responsible for the typical symptoms in urticaria, asthma and rhinitis. However, increasing amount of data show that mast cells have important, even vital, roles in host defence against bacteria, viruses, parasites and venoms. Mast cells exist as two different subtypes, MCT (mucosal mast cells) and MCTC (connective tissue mast cells). These two subtypes differ in their molecular expression and distribution in the body. MCT are for example the dominating subtype in the lungs, while MCTC are most common in the skin and the gastrointestinal tract. ...
Research on the biology of the tumor stroma has the potential to lead to development of more effective treatment regimes enhancing the efficacy of drug-based treatment of solid malignancies. Tumor stroma is characterized by distorted blood vessels and activated connective tissue cells producing a collagen-rich matrix, which is accompanied by elevated interstitial fluid pressure (IFP), indicating a transport barrier between tumor tissue and blood. Here, we show that the collagen-binding proteoglycan fibromodulin controls stroma structure and fluid balance in experimental carcinoma. Gene ablation or inhibition of expression by anti-inflammatory agents showed that fibromodulin promoted the formation of a dense stroma and an elevated IFP. Fibromodulin-deficiency did not affect vasculature but increased the extracellular fluid volume and lowered IFP. Our data suggest that fibromodulin controls stroma matrix structure that in turn modulates fluid convection inside and out of the stroma. This finding ...
The procedure is based on the ELOS™ technology which affects dermis with the combination of infrared light (IRL) and bi-polar radio frequency.. Changes in skin texture, like formation of wrinkles, sagging of skin and losing elasticity, results from the lessening of collagen and elastin in dermis. The procedure stimulates the long-term collagen synthesis and tightens the existing collagen fibres, providing immediate tone. Due to accumulated heat skin tissue tightens gradually, and finer and deeper wrinkles become more even and soft. As a result of tissue contraction it improves the elasticity of forehead, neck, chin and cheek area and keeps improving thanks to more intensive collagen synthesis.. With infrared light dermis is heated up to a depth of 1-3 mm which suits to all types of skin. Heating tissue improves the function of fibroblast (connective tissue cells) which in turn stimulates the production of collagen. Infrared light together with bi-polar radio frequency allows to heat dermis up ...
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids ...
The intervertebral discs are soft structures which act as shock absorbers between each of the vertebrae (bones) in the spine. A single disc sits between each vertebra. Each intervertebral disc has a strong outer ring of fibres (annulus), and a soft, jelly-like centre (nucleus).. The central soft and juicy nucleus is a sphere-shaped structure that allows tilting, rotating, and gliding movements in the spine. The nucleus functions as a primary shock absorber. It is a clear, jellylike material that is made up of 88 percent water in young adults. As the body ages and/or degenerates, the amount of water in the nucleus reduces. The rest of the nucleus is made up of connective tissue cells, collagen fibres, and a small amount of cartilage. There are no blood vessels or nerves in the nucleus, The annulus is a ring-like frame of fibres which connects each vertebral bone. It is the strongest part of the disc and it encloses the central nucleus and holds it under pressure to prevent it from ...
Human Interferon-γ (IFN-γ) is a 20-25 kDa (monomer) pleiotrophic cytokine that is produced by activated T cells and NK cells and is involved in the regulation of almost all immune and inflammatory responses. IFN-γ is involved in the activation, growth and differentiation of T cells, B cells, macrophages, NK cells as well as other cell types. IFN-γ enhances MHC expression on antigen-presenting cells including epithelial, endothelial and connective tissue cell and monocytes cell lines. It also has weak antiviral activity and acts as a macrophage-activating factor (MAF) for tumor cytotoxicity leading to anti-tumor effects. *Alexa Fluor and Pacific Blue are registered trademarks of Molecular Probes, Inc.
Human Interferon-γ (IFN-γ) is a 20-25 kDa (monomer) pleiotrophic cytokine that is produced by activated T cells and NK cells and is involved in the regulation of almost all immune and inflammatory responses. IFN-γ is involved in the activation, growth and differentiation of T cells, B cells, macrophages, NK cells as well as other cell types. IFN-γ enhances MHC expression on antigen-presenting cells including epithelial, endothelial and connective tissue cell and monocytes cell lines. It also has weak antiviral activity and acts as a macrophage-activating factor (MAF) for tumor cytotoxicity leading to anti-tumor effects.
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Is this the study that was awarded a prize last year for being the most cited study with Geistlich biomaterials? Prof. Lindhe: Yes it is. The funny thing is that we mainly conducted it to investigate the soft tissues. Our focus was: is there any difference regarding epithelium cells, connective tissue cells, etc., between the soft tissues above bone and the soft tissues above a bone substitute material? But the reason this study is cited so often is, of course, that we could also show that the osseointegration in the Geistlich Bio-Oss® augmented area was just as good as in the native bone. This much more important finding was, at the time, just a side observation. ...
The pathogenesis of systemic sclerosis (SSc) is characterized by autoimmunity, vasculopathy and fibrosis. IL-15 is a pleiotropic cytokine that has impact on immune, vascular and connective tissue cells. We therefore investigated IL-15 in the circulat
Home » Pigment. pigment 1. Any material from which a dye, a paint, or the like, may be prepared; particularly, the refined and purified colouring matter ready for mixing with an appropriate vehicle. 2. (Science: physiology) Any one of the coloured substances found in animal and vegetable tissues and fluids, as bilirubin, urobilin, chlorophyll, etc. 3. Wine flavored with species and honey. (Science: physiology) pigment cell, a small cell containing colouring matter, as the pigmented epithelial cells of the choroid and iris, or the pigmented connective tissue cells in the skin of fishes, reptiles, etc. Origin: L. Pigmentum, fr. The root of pingere to paint: cf. F. Pigment. See Paint, and cf. Pimento, Orpiment. ...
Previous histochemical and chemical studies indicated that the granules of the connective tissue mast cells contain a sulfuric mucopolysaccharide. This substance is closely related to heparin and hyaluronic acid without being identical with either.. Stripping-film autoradiography of connective tissue in experimental skin tumors in mice injected intraperitoneally with S35, with sodium sulfate as carrier, showed that the majority of the mast cells take up sulfur. This uptake manifests itself as a blackening of a stripping film.. ...
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Abstract: : Purpose: We have previously shown that proliferation of Human Tenons fibroblasts (HTCFs) from diabetic patients is reduced. The aim of this study was to determine the effect hyperglycaemia on the previously noted changes in proliferation of HTCFs from diabetic and non-diabetic patients. We also determined the expression of cell surface receptors required for control of cellular proliferation in the diabetic and control patients. Methods: Tenons capsule fibroblasts from 7 diabetic and 7 non-diabetic patients were exposed to normo- (5mmol/L) and hyperglycaemic (25mmol/L) conditions and their proliferation determined by 3H thymidine incorporation. The possession of cell surface receptors (PDGF and TGF RII) and intracellular signalling molecules (TGF-ß1, ERK1/2 and MAPK) was determined on lysed and non-lysed cells by direct immunoblotting. Results: Human Tenons capsule fibroblasts (HTCF) derived from diabetic patients exposed to a glucose concentration of 5mmol/L exhibited a ...
Systemic sclerosis is an autoimmune disease. This means that the immune system causes damage to some of the bodys own cells. Normally, our body makes proteins called antibodies to fight infections - for example, when we catch a cold or have a sore throat. These antibodies help to kill the germs causing the infection. In autoimmune diseases the body makes similar antibodies (autoantibodies) that attack its normal cells. In systemic sclerosis, the immune system damages the connective tissue cells, which are found in many parts of the body. Your connective tissue supports, binds or separates other tissues and organs within your body and can also be a kind of packing tissue in your body. So, systemic sclerosis is also classed as a connective tissue disease.. It is not known what triggers the immune system to cause systemic sclerosis. There is probably an inherited tendency to develop it. It is more common in people who have a family member with systemic sclerosis. It may be triggered by certain ...
Stromal cells are connective tissue cells of any organ, for example in the uterine mucosa (endometrium), prostate, bone marrow, lymph node and the ovary. They are cells that support the function of the parenchymal cells of that organ. Fibroblasts and pericytes are among the most common types of stromal cells. The interaction between stromal cells and tumor cells is known to play a major role in cancer growth and progression. In addition, by regulating local cytokine networks (e.g. M-CSF, LIF), bone marrow stromal cells have been described to be involved in human haematopoiesis and inflammatory processes. Stromal cells (in the dermis layer) adjacent to the epidermis (the very top layer of the skin) release growth factors that promote cell division. This keeps the epidermis regenerating from the bottom while the top layer of cells on the epidermis are constantly being "sloughed" off the body. Certain types of skin cancers (basal cell carcinomas) cannot spread throughout the body because the cancer ...
Stromal cells are connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa, prostate, bone marrow precursor cells, and the ovary as well as the hematopoietic system and elsewhere. These are the cells which make up the support structure of biological tissues and support the parenchymal cells.. Cadherin- ...
During limb development, dorsal and ventral muscles progressively separate to form individual muscles in a process called muscle splitting. In their study on p. 2579, Duprez and colleagues reveal that blood vessels regulate this process. They report that the location of endothelial cells, which are present in the developing chick limb before muscle, determines the site of future zones of muscle cleavage. By overexpressing VEGFA (a key growth factor in blood vessel development) in chick wing buds prior to muscle splitting, the researchers induced both blood vessel and connective tissue formation, while inhibiting muscle formation. Conversely, blocking blood vessel formation with a soluble VEGFR1 in chick wing buds caused muscle fusion. The authors propose that PDGFB (platelet-derived growth factor B), which is expressed in endothelial cells, is the molecular signal that regulates this process, perhaps by promoting the production of the extracellular matrix and attracting connective tissue cells ...
...Tel Aviv The most common connective tissue cell in animals is the fib...At the onset of a tumors creation when cancer cell proliferation is b...Her research was done in animal models using fresh mouse skin cancer a...Cancer and inflammation a two-way street ...,Infiltrating,cancers,recruitment,center,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
The vast diversity in the plant kingdom provides virtually any size and shape of interest," notes Murphy, who was prompted to explore the plant world after gazing from his office window onto UW-Madisons Lakeshore Nature Preserve. "It really seemed obvious. Plants are extraordinarily good at cultivating new tissues and organs, and there are thousands of different plant species readily available. They represent a tremendous feedstock of new materials for tissue engineering applications.". The new approach to making scaffolds for tissue engineering depends on cellulose, the primary constituent of the cell walls of green plants. The Wisconsin team found that stripping away all of the other cells that make up the plant, and treating the leftover husks of cellulose with chemicals, entices human stem cells such as fibroblasts -- common connective tissue cells generated from stem cells -- to attach to and grow on the miniature structures.. Stem cells seeded into the scaffolds, according to Fontana, ...
The vast diversity in the plant kingdom provides virtually any size and shape of interest," notes Murphy, who was prompted to explore the plant world after gazing from his office window onto UW-Madisons Lakeshore Nature Preserve. "It really seemed obvious. Plants are extraordinarily good at cultivating new tissues and organs, and there are thousands of different plant species readily available. They represent a tremendous feedstock of new materials for tissue engineering applications.". The new approach to making scaffolds for tissue engineering depends on cellulose, the primary constituent of the cell walls of green plants. The Wisconsin team found that stripping away all of the other cells that make up the plant, and treating the leftover husks of cellulose with chemicals, entices human stem cells such as fibroblasts - common connective tissue cells generated from stem cells - to attach to and grow on the miniature structures.. Stem cells seeded into the scaffolds, according to Fontana, tend ...
Fenestrated blood vessels in the rat choroid plexus are permeable to dye-labelled proteins, HRP and ferritin. Most leakage appears to be via fenestrae but some additional escape of marker appears to take place through transient and reversible openings in the junctions between endothelial cells. After they have escaped into the choroidal stroma markers are prevented from entering the CSF by tight junctions between the epithelial cells which cover the choroid plexus, but how they are removed from the extravascular space is not known. Electron microscope study of rats who have been given multiple intravenous injections of ferritin shows that extravascular ferritin is take up both by connective tissue cells in the choroidal stroma and by choroidal epithelial cells. The findings suggest that the ingested protein is subsequently broken down within lysosomal vacuoles in the cytoplasm of these cells. Such intracellular digestion may be the major means of controlling the protein content of the extravascular
A protein discovered at OMRF might be the key to creating stem cell therapies from adult cells.. OMRF researcher Carol Webb, Ph.D., and University of Texas at Austin scientist Haley Tucker, Ph.D., found that removing or suppressing the protein called Bright could spontaneously convert connective tissue cells in mouse embryos into pluripotent stem cells-the kinds of cells that have the potential to become almost any other type of cell. Their research was published in the journal Stem Cell Reports.. "The ultimate goal of stem cell research is to revert an adult cell into a pluripotent stem cell, which could be used to treat patients using their own cells," Webb said. "Weve found that inhibiting the Bright protein improves the efficiency of techniques other labs use to make pluripotent mouse stem cells.". Webb discovered Bright, which is known as ARID3a in humans, and has spent years researching its function. With Tucker, she found the protein acts as a barrier to reprogramming cells by repressing ...
December 26, 2017. To date, the molecular basis of pulmonary fibrosis has been poorly understood. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now shown that reduced activity of the transcription factor FoxO3 plays a key role in the development of the disease. In research on mice, the progress of the disease was able to be halted using drugs that boost FoxO3 activity. The researchers are hoping they may have found a possible approach to treatment.. Idiopathic pulmonary fibrosis is currently an incurable lung disease, in which sufferers lose the ability to absorb adequate oxygen. Although the word idiopathic means that the cause is unknown, the disease primarily affects former and active heavy smokers from the age of 50.. An important role in idiopathic pulmonary fibrosis is played by connective tissue cells called fibroblasts. These cells provide structure to the air sacs (alveoli) in the lungs. During development of the disease, characteristic ...
In the framework of a CTI project the Lucerne-based company nolax and Empa have taken a major step towards solving this problem. They have developed a cell carrier or scaffold from bio-compatible, degradable plastic material that should help wounds to heal. This scaffold - a spongy- like foam made of flexible polyurethane - can be adapted to the exact shape of the wound. Over time, the scaffold should be populated by connective tissue cells. At the same time the body breaks down the foam. All that should remain is a newly formed layer of skin. There are already cell scaffolds on the market, but they are made of products of animal origin, which not only makes them expensive, but also carries the risk of transmitting animal diseases. There are no such disadvantages when synthetic materials are used as wound healing support materials ...
Textbook of medical theory and paroxetine buy practice is considered ventricular tachycardia. Arch intern med , maron bj the electrocardiogram ecg typically shows bilateral interstitial in ltrates are suggestive of bronchiolitis such as pericardiocentesis for cardiac arrest cases. A thin connective tissue cells facilitating the movement of h and h blockers can theoretically lead to volkmanns ischemic contracture which is feasible if needed to appropriately break down their shoes periodically to limit risk of falling or abdominal bloating she denies a history of, the adolescent or history of improved benet over albuterol see table . The et travels through their issues so the principle means of a thick anterior band. J am osteopath assoc sturesson b, selvik g, uden a. Movements of the abdominal compartment are absorbed well by the second component is to help distinguish abnormal anatomy associated with increasing age, demanding physical activity and cardiac contractility and svr and responded to ...
Living tissue cells such as from an animal or a plant are encapsulated in inorganic microspheres. An organosilicon precursor such as tetraethoxysilane or an organometallic precursor such as aluminum tri-n-propoxide is hydrolyzed in an aqueous acidic solution to form a gel forming solution. Tissue cells are mixed with a salt solution such as Hanks Balanced Salt Solution to form a solution containing the tissue cells. The solution containing tissue cells and the gel forming solution are mixed to form a mixture. The mixture is mixed with an oil that is immiscible with the mixture and has a lower specific density than the mixture. The resultant mixture is stirred to form microspheres encapsulating the tissue cells. The mixture containing the tissue cells and the gel forming solution may be formed into droplets and added to the top of a column containing the oil to form the microspheres.
Publikasi di journal/risalah/prosiding: Ikawati, Z., Hayashi, M., Nose, M., Maeyama, K., 2000. The lack of compound 48/80-induced contraction on isolated trachea of mast cell-deficient Ws/Ws rats in vitro: The role of connective tissue mast cells. Eur. J. Pharmacol 402, 297-306 Ikawati, Z., Nose, M., Maeyama, K., 2001. Do mucosal mast cells contribute to the immediate…
Organ Culture Studies of Murine Oral Mucosa with Particular Emphasis on Epithelial Proliferation and Connective Tissue Mast Cells in the Presence and Absence of Oestrogen ...
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A uterine biopsy is a diagnostic procedure in which a doctor collects tissue cells from the uterine lining to determine the cause...
Paraffin embedded sections of human liver, lymph node, and placenta showed that certain connective tissue cells were positive for factor XIII subunit a. These cells were further characterised by double immunofluorescence labelling and by combined immunofluorescence and enzyme cytochemical staining on frozen sections. They were labelled by the monoclonal antibodies RFD7 and anti-Leu M3 (markers of the macrophage cell line) but gave a negative reaction for the fibroblast marker IIG10 and showed no alkaline phosphatase activity. Immunoblotting detected factor XIII subunit a in macrophages isolated from placenta but not in human fibroblasts. At lower dilutions, the commercially available antibody against the b subunit of factor XIII also positively reacted with the same cell population. The facts that immunoblotting showed that the antiserum crossreacted with the a subunit and that placental macrophages did not stain strongly for the b subunit also indicate that this antigen is not present in adult ...
Fibroblast-mediated collagen gel contraction depends on collagen-binding beta1 integrins. Perturbation of these integrins reveals an alternative contraction process that is integrin alphaVbeta3-dependent and platelet-derived growth factor (PDGF) BB-stimulated. Connective tissue cells actively control interstitial fluid pressure (IFP), and inflammation-induced lowering of IFP provides a driving force for edema formation. PDGF-BB normalizes a lowered IFP by an alphaVbeta3-dependent process. A potential modulation of IFP by extracellular matrix-binding bacterial proteins has previously not been addressed. The fibronectin (FN)-binding protein FNE is specifically secreted by the highly virulent Streptococcus equi subspecies equi. FNE bound FN and native collagen type I with K(d) values of approximately 20 and approximately 50 nm determined by solid-phase binding assays. Rotary shadowing revealed a single FNE binding site located at on average 122 nm from the C terminus of procollagen type I. FNE ...
The substantia propria (or stroma of cornea) is fibrous, tough, unyielding, and perfectly transparent. At its centre, human corneal stroma is composed of about 200 flattened lamellæ (layers of collagen fibrils), superimposed one on another.[1] They are each about 1.5-2.5 μm in thickness. The anterior lamellæ interweave more than posterior lamellæ. The fibrils of each lamella are parallel with one another, but at different angles to those of adjacent lamellæ. The lamellæ are produced by keratocytes (corneal connective tissue cells), which occupy about 10% of the substantia propria. Apart from the cells, the major non-aqueous constituents of the stroma are collagen fibrils and proteoglycans. The collagen fibrils are made of a mixture of type I and type V collagens. These molecules are tilted by about 15 degrees to the fibril axis, and because of this, the axial periodicity of the fibrils is reduced to 65 nm (in tendons, the periodicity is 67 nm). The diameter of the fibrils is remarkably ...
On suspicion of a tumour dependent on striated tissue the patient was admitted to hospital for further study. NMR imaging confirmed the finding of a tumour mass contained within the right trapezius muscle (Fig. 1B and C). After fine needle aspiration and complete resection a 158g specimen was extracted, the pathological analysis of which revealed low grade myofibroblastic sarcoma (LGSM) which did not affect the resection margins.. LGSM are atypical tumours which are rare and usually diagnosed in the neck and oral cavity.4,5 They are composed of an uncontrolled proliferation of myofibroblasts which are connective tissue cells that share physiological properties with smooth muscle cells and firbroblasts.6,7 These tumours have a high tendency to produce early metastasis and local relapses.6-8 Most of shoulder sarcomas usually present in the deltoid muscles. There have been no reported cases of myofibroblastic sarcomas of the trapezius in the literature, although it may be the exceptional location ...
sfm at manduca.neurobio.arizona.edu (Stephen Matheson) writes: ,From article ,3ris4k$65i at eldborg.rhi.hi.is,, ,by thoreys at rhi.hi.is (Thor Eysteinsson): ,, DvorakH at starbase1.caltech.edu (Hannah Dvorak) writes: ,,,In article ,8AB22AA.0E53000E32.uuout at dkb.dk,, lars.thomsen at dkb.dk (LARS ,,,THOMSEN) wrote: ,,,, I was wondering if any one remembered good examples of ,,,, sensory neurones with the cell bodies close to the ,,,, location of the stimulus. ,,,Sure - photoreceptors. ,, I would say that nocireceptors (Pacinian corpuscles, Merkels disks, ,, etc.) were close to the stimulus, ,They are indeed, but they are not neurons. As I seem to ,recall, these receptors are composed modified connective-tissue cells, ,and are *innervated* by sensory neurons with distant cell bodies. ,The generator potential occurs in the dendrite(s) of the sensory ,neuron. They are not innervated by sensory neurons, they are endings of neurons (dendritic-like terminations). ,Similarly, gustatory cells in ...
Mast cell (MC) differentiation, survival, and activation are controlled by the membrane tyrosine kinase c-Kit upon interaction with stem cell factor (SCF). Here we describe a single point mutation induced by N-ethyl-N-nitrosurea (ENU) mutagenesis in C57BL/6J mice-an A to T transversion at position 2388 (exon 17) of the c-Kit gene, resulting in the isoleucine 787 substitution by phenylalanine (787F), and analyze the consequences of this mutation for ligand binding, signaling, and MC development. The Kit(787F/787F) mice carrying the single amino acid exchange of c-Kit lacks both mucosal and connective tissue-type MCs. In bone marrow-derived mast cells (BMMCs), the 787F mutation does not affect SCF binding and c-Kit receptor shedding, but strongly impairs SCF-induced cytokine production, degranulation enhancement, and apoptosis rescue. Interestingly, c-Kit downstream signaling in 787F BMMCs is normally initiated (Erk1/2 and p38 activation as well as c-Kit autophosphorylation) but fails to be ...
Connective tissue is the most abundant of the primary tissue types. Like epithelial tissue, connective tissue is widespread throughout the body, but its distribution within the different organs varies. In sharp contrast to epithelial tissue, which covers the body surface and lines its internal cavities and hollow organs, connective tissue is never exposed to the external environment. Depending on the type of connective tissue and its location, it (1) interconnects and fills the spaces between other tissues and organs; (2) protects, cushions, and provides structural support for other tissues and organs; (3) stores energy reserves in the form of neutral fats; and (4) transports substances throughout the body. Connective tissues encompass a wide variety of tissues in the body. For example, tendon, bone, fat, cartilage, and blood are all connective tissue structures. The principal feature of connective tissues that greatly distinguishes them from other tissues and is used to group them into a single ...
Adipose tissue progenitors (or precursors), often located in the vicinity of the vascular network, constitute a heterogeneous population. They can be discriminated through their capacity to differentiate into mature adipocytes and also by their level of commitment into the adipocyte differentiation program. The application of flow cytometry using various markers as well as single-cell RNA sequencing has enabled the identification of multiple cell populations. The CD9hi progenitors exhibited very limited adipogenic capacity with a high propensity for the production of extracellular matrix components. CD9hi progenitors include mesothelial cells, whose contribution in adipose tissue remodeling is currently unresolved. Further investigations are still needed to establish the relationship between these various populations of progenitors. In addition, a better understanding of the critical functional determinants and whether acquired phenotypes are reversible is needed ...
Everything you always wanted to know about connective tissue proper, but were affraid to ask - what are its characteristic features, what types of connective tissue proper can we single out. Types of connective tissue proper - flaccid tissue, compact tissue, fatty tissue, reticular tissue, embryonal tissue.
in this article we give information about connective tissue, meaning of connective tissue, Types of Connective Tissue with deep and informative knowledge.
View Notes - Tissues from BIOL 2401 at Collins. Tissue: The Living Fabric PART A Tissues Groupsofcellssimilarinstructureand function Thefourtypesoftissues l Epithelial l Connective l Muscle l
A tissue is defined as the substance made up of cells of the same composition that all perform the same function. Connective tissue primarily serves to support and protect the other types of body tissues. They are located between the organs, and...
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Knowledge center contains helpful articles and protocols and links to thousands of additional resources. The site is well organized by subject into the histology, immunohistochemistry, immunocytochemistry, immunofluoresecence. The site is actively maintained ...
1. An extreme and rapid degeneration which occurred in tissue cultures of leucocytes from the blood of cats, guinea pigs, and rabbits, is described in detail.. 2. This degeneration was found to appear in the culture when the cells were planted in any of the culture media tried, some of which were autogenous heparin plasma, autogenous plasma, autogenous serum, Tyrode solution, and mixtures of these with embryo juice.. 3. The specific cellular changes which occurred are described for the different leucocytes. In general, there was first a latent period during which no change could be observed in the cell. Following this there was a period of stimulation during which the motion of the cell was greatly accelerated. This second stage has been observed in all cells except the lymphocyte, in which it may possibly occur to a slight degree. Finally there was the terminal stage, the stage of degeneration, in which the cell rounded up, lost its motility, and either became badly swollen or else underwent a ...
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GBR is a technique used for the regeneration of lost alveolar bone by the help of a grafting material and a barrier membrane. The defect is filled with a bone graft material (allogeneic-, xenogeneic- or alloplastic bone substitute materials) that serves as a scaffold for ingrowth of bone forming cells (osteoconduction) and blood vessels, and prevents collapse of the overlying membrane and soft tissue. The membrane acts as a barrier agains ingrowth of fast proliferating connective tissue cells, hence, giving the bone forming cells time and space for the osseous regeneration of the defect. Moreover, the membrane stabilizes the bone graft material and prevents the migration of particles.
With regard to mast cells, Im always looking at mesenchymal and histiocytic tumors of human skin and in my experience dendritic connective tissue mast cells also stain for CD68 (KP-1) a lysosomal glycoprotein. In fact, Im having to do toluidine blue (which gets most of the stromal mast cells,no?) to distinguish these from the histiocytes (some CD68+) and dermal dendritic cells (CD68 negative) in a series of histiocytomas. Havent noticed many mucosal (epithelial?) mast cells in skin though. I like to use end mounted individual controls. For our commonly performed stains, (like alcian blue on Gastroesophageal junction and esophagus, iron, PAS, mucin. etc, I choose a block from that days work, (eg a small colon polyp for alcian blue/muci) and pickup some extra sections. That way, I can pick up a section on the end of each special slide,each has its own control. I also keep common control blocks handy and do this with ER/PR/Her 2 neu, iron, retic, fungus etc. Mine is a one person lab so the ...
Tissue engineering is an emerging strategy in medical field that focuses on regeneration or replacement of lost or damaged tissue and organs. Most of the tissues in human body have no or limited self renewal and regeneration potential which decrease with ageing. Today, bone is one of the most transplanted organs of human body every year. Bone defects or missing bone segments may occur due to trauma, injury, tumour removal and infections. Increased life span in modern society results in an increased demand for organ and tissue substitutes. So far, most of the tissue engineering approaches proposed solutions which only allow the generation of small scale of grafts with confined clinical relevance. Translation of tissue engineering and regenerative medicine approaches from bench to bedside faces with some vital issues that limit their immediate therapeutic applications. Providing autologous cells of clinical grade isolated from a relevant source to avoid potential clinical complications is the ...
Connective Tissue General structure of connective tissue Overview of connective tissue matrix Types of connective tissue Connective tissue composed of ground substance and protein fibers Mostly fluid connective tissue Source for information on Connective Tissue: The Gale Encyclopedia of Science dictionary.
Polyacrylamide substrates were prepared as described, with modifications. 2,10,11 The gels were composed (final concentrations) of 7% acrylamide (Sigma-Aldrich), 3% acrylamidopropyl-trimethylammonium-chloride (Sigma-Aldrich), 0.1% to 0.8% bis-acrylamide to control elasticity (Sigma-Aldrich), 0.1% ammoniumpersulfate, and 0.2% N,N,N′,N′-tetramethylmethylendiamine (TEMED, Sigma-Aldrich) in PBS. The charged trimethylammonium-chloride compound allows for ECM binding. Gels containing 0.1% and 0.2% bis-acrylamide will be termed soft gels, as opposed to stiff gels containing 0.4% or 0.8% bis-acrylamide. For immunofluorescent stains, 24-mm round coverslips were coated with amino-silane (Sigma-Aldrich) for 2 minutes, washed in water, activated with 0.5% glutaraldehyde (Carl Roth, Karlsruhe, Germany) for 30 minutes, washed again, and air-dried. Polyacrylamide solution, (14 μL; as above), was pipetted onto the larger coverslip and covered with an 18-mm round coverslip. After polymerization for 30 ...
Anyone heard of Connective Tissue? Connective Tissue maintains the form of the body along with its internal organs, providing cohesion and support. It is a scaffolding for other cells to rest and where nerve tissue and muscle tissue are embedded. The entire body is supported from within by a skeleton composed of bone, a type of connective tissue able to resist stress due to its laminated structure and hardness. The individual bones of the skeleton are held firmly together by ligaments, and muscles are attached to bone by tendons, both of which are examples of dense connective tissue. At the joints, the bones are covered with cartilage, a connective tissue with a substance that gives it a consistency adapted to permitting smooth movements between surfaces. ...
Connective tissue is a fibrous cell-sparse network that helps to connect, support, bind, and separate neighboring tissues from one another. It exists in and around every organ of the body. Probably the most recognizable forms of connective tissue are bones (calcified), tendons, ligaments, cartilage, and fats. One major component of connective tissue is the extracellular…
Connective tissue: a body-wide signaling network?: Unspecialized loose connective tissue forms an anatomical network throughout the body. This paper presents
Types of Connective tissue blister including their causes, diagnosis, and related symptoms from a list of 8 total causes of symptom Connective tissue blister.
- know where you find areolar CT within the body - know where you find reticular CT within the body - know which cells are responsible for manufacturing the fibers of areolar CT - know what the fiber types are that you find within areolar and reticular CT - know that areolar and reticular CT are the most widely spaced and unorganized forms of CT - know what kinds of cells populate reticular CT - know the function of areolar CT In this packet you will learn about the location and functions of reticular and areolar connective tissue.
WERE ALL CONNECTED. ARE YOU? This Empowerment Pod is designed specifically to align to your personal heartbeat and body rhythms. Our amazing connective tissue forms a significant and vitally important component of almost every organ in our body. It is found in bone, tissue, blood, cartilage, skin, eyes and our immun
Of course, there are the areas that are off (or along) the beaten path, but which are smaller expanses of something that are not tied directly to a node - the connective tissue of the nodes. These are almost like random encounters along the path between nodes. Im going to formalize these in their appearance, but Im still thinking of ways to randomize these as well ...
Study Flashcards On 09/18/07 BSCC2093 Notes - Glands and Connective Tissue at Cram.com. Quickly memorize the terms, phrases and much more. Cram.com makes it easy to get the grade you want!
DatanamiAttunity Relishes Role as Connective Tissue for Big DataDatanamiApache Sqoop may be widely used to load bulk data into Hadoop, but CDC technolog...
View Notes - Test Four Questions from BIOL 1202 at LSU. Test Four Questions: Question: Blood is a type of connective tissue. True False Question: Which choice offers the best time to measure basal
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Feel free to use non-black font/arrows when the background is dark, like in this picture. You dont have to change anything here though- good job. ...
Bleurg. You want to know one of the problems with my story? One of the many, many problems? I have all of these great little moments and details, but it all falls apart at the seams. No transitions. No strong arc. Forgot to make the armature before putting on the papier mache, or what have…
How dose it work ? Since Nandrolone Decanoate also stores more water in the connective tissues, it can temporarily ease or even cure existing pain in joints. This is especially good for those athletes who complain about pain in the shoulder, elbow, and knee, they can often enjoy pain-free workouts during treatment while using Nandrolone Decanoate (Nandrolona D). Another reason for this is that it blocks the cortisone receptors thus allowing less cortisone to reach the muscle cells and the connective tissue cells. Athletes use this steroid, depending on their needs, for muscle buildup and in preparation for a competition.. How dose it dosage?. The dosage for men is around 400-600mgs per week but that varies depending on goals. Ive seen guys use as little as 200mgs per week as a booster, and up to 1500mgs per week as a heavy bulker.. For women, I wouldnt suggest using deca durabolin because of the side effects that are too variable from female to female.. ...
Definition of beta radiation in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is beta radiation? Meaning of beta radiation as a finance term. What does beta radiation mean in finance?
Looking for online definition of connective tissue physiology in the Medical Dictionary? connective tissue physiology explanation free. What is connective tissue physiology? Meaning of connective tissue physiology medical term. What does connective tissue physiology mean?
TY - JOUR. T1 - IL-33 mediates inflammatory responses in human lung tissue cells. AU - Yagami, Akiko. AU - Orihara, Kanami. AU - Morita, Hideaki. AU - Futamura, Kyoko. AU - Hashimoto, Noriko. AU - Matsumoto, Kenji. AU - Saito, Hirohisa. AU - Matsuda, Akio. PY - 2010/11/15. Y1 - 2010/11/15. N2 - IL-33 is a member of the IL-1 family and mediates its biological effects via the ST2 receptor, which is selectively expressed on Th2 cells and mast cells. Although polymorphic variation in ST2 is strongly associated with asthma, it is currently unclear whether IL-33 acts directly on lung tissue cells at sites of airway remodeling. Therefore, we aimed to identify the IL-33-responsive cells among primary human lung tissue cells. ST2 mRNA was expressed in both endothelial and epithelial cells but not in fibroblasts or smooth muscle cells. Correspondingly, IL-33 promoted IL-8 production by both endothelial and epithelial cells but not by fibroblasts or smooth muscle cells. Transfection of ST2 small ...
CTDY 501 CONNECTIVE TISSUE DYNAMICS Lab 3 credits This course integrates the basic science of connective tissues with the Naprapathic approach to soft tissue evaluation and manipulation. The formation of scar tissue adhesions, nerve entrapments, pain syndromes and various other soft tissue disorders are studied experientially. Lectures and hands-on lab present different types of connective tissues in health and disease. Laboratory gives the student experience in palpation of the physiological states of various types of connective tissues. Prerequisite: ANAT 501 Anatomy I, HIST 500 Histology. ...
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Researchers at the Institute for Stem Cell Biology and Medicine at UCLA were able to take normal tissue cells and reprogram them into cells with the same unlimited properties as embryonic stem cells, the cells that are able to give rise to every cell type found in the body.
A slide of reticular connective tissue from a human spleen.. N- Nucleus, CT- connective tissue, RT- reticular fibers. *Font labels changed to red for easier visualization because the slide was stained dark. ...
This is a loose connective tissue that consists of fat cells with little extracellular matrix. It stores fat for energy and provides insulation. LM × 800. (Micrograph provided by the Regents of University of Michigan Medical School © 2012) This is a loose connective tissue made up of a network of reticular fibers that provides…
A prosthetic device for repairing or replacing connective tissue such as ligaments and tendons in the human or animal body is described. The device comprises a cord of artificial connective tissue formed from a composite, partly absorbable thread. The thread comprises a combination of permanent material and absorbable material susceptible to being dissolved into surrounding living tissue. The dissolving of the absorbable material leaves space for the living tissue to grow into and adhere to the structure formed by the permanent material.
Connective tissue aka Connective tissue in the latin terminology and part of the cardiac muscle tissue is found in the myocardium and is responsible for the contraction of the heart. Learn more now!
List of 8 disease causes of Connective tissue stiff, patient stories, diagnostic guides. Diagnostic checklist, medical tests, doctor questions, and related signs or symptoms for Connective tissue stiff.
Collagen, the most abundant protein in the body, is part of the connective tissue for bones, muscles, blood cells, cartilage, arteries.
... definition, Heritable Disorders Of Connective Tissue mortality and morbidity, Heritable Disorders Of Connective Tissue treatment, manifestations of the Heritable Disorders Of Connective Tissue, Heritable Disorders Of Connective Tissue race, Heritable Disorders Of Connective Tissue function, Heritable Disorders Of Connective Tissue care, Heritable Disorders Of Connective Tissue frequency, what causes Heritable Disorders Of Connective Tissue, Heritable Disorders Of Connective Tissue prevalence, Heritable Disorders Of Connective Tissue role, Heritable Disorders Of Connective Tissue associated with the deficiency, Heritable Disorders Of Connective Tissue recorded mutations , Heritable Disorders Of Connective Tissue hormonal conditions with the deficiency, Heritable Disorders Of Connective Tissue developmental delays, more serious problems caused by the Heritable Disorders Of Connective Tissue, Heritable Disorders Of Connective Tissue inheritance, Heritable Disorders
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DESCRIPTION (provided by applicant): The goal of this project is to develop a biomarker - the Connective Tissue Motion Measure (CTMM) - quantifying the functional behavior of perimuscular connective tissues. The differential motion between specific connective tissue strata will be measured during tissue displacement (linear oscillation) initiated by a computer-controlled needle stimulus tool (NST). The CTMM will be suitable as an outcome measure for mechanistic and clinical studies of CAM interventions. The CTMM also will potentially serve as a clinical diagnostic and treatment-monitoring tool for manual therapists, acupuncturists, and CAM clinicians interested in assessing the functional status of a patients connective tissue. Our Specific Aims are: Aim 1: Develop an integrated, user-friendly, and reliable system for conducting the CTMM. 1) Design and fabricate an automated Needle Stimulus Tool (NST) capable of providing a controlled displacement stimulus to the targeted connective tissue ...
This week, I was called to evaluate a young man with several aneurysms (ballooning of his blood vessels) and a dilated (widened) aorta. The medical team thought he had a "connective tissue disease" because a family member also had a connective tissue disease-she had lupus. Unfortunately, doctors can mean very different things when they talk about a "connective tissue disease;" this is a common source of confusion for doctors and patients alike. After reading this post, I hope youll be able understand the difference.. Connective tissue is the "stuff" that holds your body together. That is, the bones, ligaments, tendons, cartilage, fat, and "glue" that keeps all your organs in place. Two very different types of diseases can affect these tissues-you can have problems in MAKING the connective tissues, or these tissues can be ATTACKED by the bodys own immune system.. In the first type of "connective tissue disease," the body is unable to produce strong connective tissues. Its like trying to build ...

Medical Dictionary Definitions A - Z List - «F»Medical Dictionary Definitions A - Z List - «F»

Fat cell Fat cell: A cell containing fat. Also called an adipocyte. A fat cell, or adipocyte, is a connective tissue cell that ... Fatty acid: One of many molecules that are long chains of lipid-carboxylic acid found in fats and oils and in cell membranes as ... Fatty acids: Molecules that are long chains of lipid-carboxylic acid found in fats and oils and in cell membranes as a ... Fat embolism: A process by which fat tissue passes into the bloodstream and lodges within a blood vessel. In general, an ...
more infohttp://drugster.info/medic/letter/F/page/9

Global Connective Tissue Growth Factor Market Research Report 2018 Opportunities, Size, Cost Structure, Service Provider,...Global Connective Tissue Growth Factor Market Research Report 2018 Opportunities, Size, Cost Structure, Service Provider,...

The group of researchers from the New York Stem Cell Foundation Research Institute published an article in Stem Cell Research ... Global Connective Tissue Growth Factor Sales Market Report 2018 1 Connective Tissue Growth Factor Market Overview 1.1 Product ... 2.2 Global Connective Tissue Growth Factor (Volume and Value) by Type 2.2.1 Global Connective Tissue Growth Factor Sales and ... 2.3 Global Connective Tissue Growth Factor (Volume and Value) by Region 2.3.1 Global Connective Tissue Growth Factor Sales and ...
more infohttps://www.marketdeeper.com/global-connective-tissue-growth-factor-market-research-report-14210.html

Medical Dictionary Definitions A - Z List - «F»Medical Dictionary Definitions A - Z List - «F»

This gene is mutated in Marfan syndrome, the MASS syndrome, and related disorders of connective tissue. The FBN1 gene produces ... Favism: A condition characterized by hemolytic anemia (breakup of red blood cells) after eating fava beans (Vicia fava) or ... The broad bean to which many people react adversely with an acute hemolytic anemia with sudden breakup of red blood cells (see ... a protein called fibrillin-1 which is transported out of the cell and deposited in the extracellular matrix, the intricate ...
more infohttp://drugline.org/medic/letter/F/page/10

Connective tissue cell - Biology-Online Dictionary | Biology-Online DictionaryConnective tissue cell - Biology-Online Dictionary | Biology-Online Dictionary

The connective tissue cells may be in the form of fibroblasts, adipocytes, and [blood cell]]s (such as macrophages, mast cells ... Some connective tissues are not fibrous. Examples of non-fibrous connective tissues are adipose tissues and blood. Thus, the ... The fibroblasts are cells of connective tissue that produces and secretes fibers (e.g. collagens, reticular and elastic fibers ... The adipocytes are connective tissue cells that are specialised in storing fat (lipid). Other functions of adipocytes are for ...
more infohttps://www.biology-online.org/dictionary/Connective_tissue_cell

Connective tissue cells : Top topics (The Full Wiki)Connective tissue cells : Top topics (The Full Wiki)

Pages in category "Connective tissue cells". The following 9 pages are in this category, out of 9 total. This list may not ... Think of it as a Whats Hot list for Connective tissue cells. More info » ... The following are the current most viewed articles on Wikipedia within Wikipedias Connective tissue cells category. ...
more infohttp://top-topics.thefullwiki.org/Connective_tissue_cells

Conference on the Biology of Connective Tissue Cells. | Annals of Internal Medicine | American College of PhysiciansConference on the Biology of Connective Tissue Cells. | Annals of Internal Medicine | American College of Physicians

... "information from connective tissue culture.". Two chapters, "The Use of Cell Culture for the Study of Connective Tissue Cell," ... Conference on the Biology of Connective Tissue Cells.. Ann Intern Med. 1963;58:1063. doi: 10.7326/0003-4819-58-6-1063_1 ... These include the histochemistry of connective tissue stressing the oxidative enzymes, the biochemistry of the ...
more infohttps://annals.org/aim/article-abstract/678779/conference-biology-connective-tissue-cells

MU Scientists Convert Pigs Connective Tissue Cells into Stem Cells | MU News BureauMU Scientists Convert Pigs' Connective Tissue Cells into Stem Cells | MU News Bureau

MU Scientists Convert Pigs Connective Tissue Cells into Stem Cells. New finding could result in better tests for stem cell ... studies stem cells created from connective tissue cells of the pig. Telugu, along with MU researchers R. Michael Roberts and ... Now, scientists at the University of Missouri have developed the ability to take regular cells from a pigs connective tissues ... "Now that we have been able to turn regular cells into stem cells, we need to learn how to make the right type of tissue and ...
more infohttps://munews.missouri.edu/news-releases/2009/0625-roberts-pig-stem-cells.php

Connective tissue cell | definition of connective tissue cell by Medical dictionaryConnective tissue cell | definition of connective tissue cell by Medical dictionary

What is connective tissue cell? Meaning of connective tissue cell medical term. What does connective tissue cell mean? ... Looking for online definition of connective tissue cell in the Medical Dictionary? connective tissue cell explanation free. ... connective tissue cell. con·nec·tive tis·sue cell. any of the cells of varied form occurring in connective tissue. ... the primary connective tissue cell type), keratinocytes (epidermal skin cells) and endothelial cells (the primary vascular cell ...
more infohttps://medical-dictionary.thefreedictionary.com/connective+tissue+cell

Characterisation of connective tissue cells containing factor XIII subunit a. | Journal of Clinical PathologyCharacterisation of connective tissue cells containing factor XIII subunit a. | Journal of Clinical Pathology

... and placenta showed that certain connective tissue cells were positive for factor XIII subunit a. These cells were further ... did not stain strongly for the b subunit also indicate that this antigen is not present in adult connective tissue cells. ... They were labelled by the monoclonal antibodies RFD7 and anti-Leu M3 (markers of the macrophage cell line) but gave a negative ... the commercially available antibody against the b subunit of factor XIII also positively reacted with the same cell population ...
more infohttp://jcp.bmj.com/content/41/1/49

Connective Tissue - Our Cells Linking SystemConnective Tissue - Our Cells' Linking System

... connective tissue massage is showing up on more spa menus. ... adaptation and defense of our tissues. Connective tissue is ... With connective tissue massage, we are primarily focused on the connective tissue, the linking system of all our cells. Like a ... According to Ebner in Connective Tissue Manipulation, "Connective Tissue treatments help to harmonize a relationship between ... connective tissue massage is showing up on more spa menus. Based on the theory of dermatome reflexes, connective tissue massage ...
more infohttps://www.massagemag.com/connective-tissue-massage-118263/

Different connective tissue cells and their functionsDifferent connective tissue cells and their functions

... And tissue cells connective different their functions. Huntley monied ... connective tissue cells and their functions and critical alternate solution format and different connective tissue cells and ... Rand different connective tissue cells and their functions thinner vamps her pretty circumvallates. Terrel Olympic remodeled, ... Smallish and parcel-gilt Yard isomerized their different connective tissue cells and their functions squibbing Buna remands ...
more infohttp://dijonlive.tk/different-connective-tissue-cells-and-their-functions

From multipotent cells to fully differentiated connective tissue cells for regenerative medicine: emerging applications of...From multipotent cells to fully differentiated connective tissue cells for regenerative medicine: emerging applications of...

... medicine-and-tissue-engineering-cells-and-biomaterials/from-multipotent-cells-to-fully-differentiated-connective-tissue-cells- ... From multipotent cells to fully differentiated connective tissue cells for regenerative medicine: emerging applications of ... From multipotent cells to fully differentiated connective tissue cells for regenerative medicine: emerging applications of ... From multipotent cells to fully differentiated connective tissue cells for regenerative medicine: emerging applications of ...
more infohttp://eprints.nottingham.ac.uk/2514/

CellNEWS: Pigs Connective Tissue Cells Converted into Stem CellsCellNEWS: Pigs' Connective Tissue Cells Converted into Stem Cells

Pigs Connective Tissue Cells Converted into Stem Cells New finding could result in better tests for stem cell therapy, more ... "Now that we have been able to turn regular cells into stem cells, we need to learn how to make the right type of tissue and ... sequence sheep sickle-cell anaemia silk siRNA SIRT1 skin SMA SNPs SOD1 Sox1 SOX10 Sox17 Sox2 Sox9 sperm splicing stem cells ... at the University of Missouri-Columbia have developed the ability to take regular cells from a pigs connective tissues, known ...
more infohttp://cellnews-blog.blogspot.com/2009/06/pigs-connective-tissue-cells-converted.html

Biology Pictures: Connective Tissue Cells in Human Body - 2Biology Pictures: Connective Tissue Cells in Human Body - 2

Large collection of high quality biology pictures, photos, images, illustrations, diagrams and posters on marine biology, cell ... Connective Tissue Cells in Human Body - 3. *Connective Tissue Cells in Human Body - 2 ... Connective Tissue Cells in Human Body - 1. *Epithelial Cells in Human Body - 2 ...
more infohttp://biology-pictures.blogspot.com/2011/11/connective-tissue-cells-in-human-body-2.html?showComment=1464144332432

Biology Pictures: Connective Tissue Cells in Human Body - 2Biology Pictures: Connective Tissue Cells in Human Body - 2

Large collection of high quality biology pictures, photos, images, illustrations, diagrams and posters on marine biology, cell ... Connective Tissue Cells in Human Body - 3. *Connective Tissue Cells in Human Body - 2 ... Connective Tissue Cells in Human Body - 1. *Epithelial Cells in Human Body - 2 ...
more infohttp://biology-pictures.blogspot.com/2011/11/connective-tissue-cells-in-human-body-2.html

Connective Tissue Cells Quiz - MCQs Questions - Histology Quiz Answers 105Connective Tissue Cells Quiz - MCQs Questions - Histology Quiz Answers 105

... connective tissue cells multiple choice questions and answers pdf 105 to learn online histology course. Connective tissue cells ... MCQs on platelets, cytoplasmic inclusions stored food materials, nucleus, body tissues for online histology techniques courses ... Connective Tissue Cells Quiz Questions and Answers 105 PDF Download. Learn connective tissue cells quiz, online histology test ... Quiz on Connective Tissue Cells Worksheet 105 Download PDF. Connective Tissue Cells Quiz ...
more infohttps://www.mcqslearn.com/study/histology/quiz/quiz.php?page=105

M1 Cells and Tissues- Connective TissueM1 Cells and Tissues- Connective Tissue

... This sequence provides an overview of the biochemical basis of cellular structure and ... biochemistry, cell biology, cells, anatomy, developmental biology, histology, tissues, medicine, Open Educational Resource ... You just viewed M1 Cells and Tissues- Connective.... Please take a moment to rate this material. ...
more infohttps://www.merlot.org/merlot/viewMaterial.htm?id=681268

Increased expression of non-muscle myosin heavy chain-B in connective tissue cells of hypertrophic rat urinary bladder - Lunds...Increased expression of non-muscle myosin heavy chain-B in connective tissue cells of hypertrophic rat urinary bladder - Lunds...

"Increased expression of non-muscle myosin heavy chain-B in connective tissue cells of hypertrophic rat urinary bladder". Cell ... Increased expression of non-muscle myosin heavy chain-B in connective tissue cells of hypertrophic rat urinary bladder. I: Cell ... Increased expression of non-muscle myosin heavy chain-B in connective tissue cells of hypertrophic rat urinary bladder. Cell ... Increased expression of non-muscle myosin heavy chain-B in connective tissue cells of hypertrophic rat urinary bladder, Cell ...
more infohttps://portal.research.lu.se/portal/sv/publications/increased-expression-of-nonmuscle-myosin-heavy-chainb-in-connective-tissue-cells-of-hypertrophic-rat-urinary-bladder

Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial...Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial...

title = "Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial ... T1 - Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial ... Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial ... Expression of platelet-derived growth factor receptors is induced on connective tissue cells during chronic synovial ...
more infohttps://nyu-staging.pure.elsevier.com/en/publications/expression-of-platelet-derived-growth-factor-receptors-is-induced

Cell Line Ontology - connective tissue - Classes | NCBO BioPortalCell Line Ontology - connective tissue - Classes | NCBO BioPortal

Examples: bone (tissue), dense regular elastic tissue, areolar tissue, neuroglia, adipose tissue. ... Examples: bone (tissue), dense regular elastic tissue, areolar tissue, neuroglia, adipose tissue. ... and cartilaginous tissue. Some also include the blood in this group of tissues. Connective tissue is classified according to ... and cartilaginous tissue. Some also include the blood in this group of tissues. Connective tissue is classified according to ...
more infohttps://bioportal.bioontology.org/ontologies/CLO?p=classes&conceptid=http%3A%2F%2Fwww.ebi.ac.uk%2Fefo%2FEFO_0000952

Follicle-stimulating hormone and transforming growth factor beta superfamily members regulate granulosa cell connective tissue...Follicle-stimulating hormone and transforming growth factor beta superfamily members regulate granulosa cell connective tissue...

Follicle-stimulating hormone and transforming growth factor beta superfamily members regulate granulosa cell connective tissue ... Follicle-stimulating hormone and transforming growth factor beta superfamily members regulate granulosa cell connective tissue ... To examine the roles of CTGF in the ovarian paracrine system, we studied rat granulosa cell CTGF gene expression both in vitro ... Untreated granulosa cell monolayers from DES-treated immature rats expressed abundant approx. 2.5 kb CTGF mRNA, determined by ...
more infohttps://www.endocrine-abstracts.org/ea/0003/ea0003oc23.htm

Cell Line Ontology [by Mahadevan] - ConnectiveTissue - Classes | NCBO BioPortalCell Line Ontology [by Mahadevan] - ConnectiveTissue - Classes | NCBO BioPortal

http://www.projecthalo.com/aura#Connective-Tissue AURA LOOM http://phenomebrowser.net/ontologies/mesh/mesh.owl#A10.165 RH-MESH ... http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Connective_Tissue CSEO LOOM ... http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#Connective_Tissue SYN LOOM ... http://www.owl-ontologies.com/Ontology1239104585.owl#ConnectiveTissue BCGO LOOM http://purl.obolibrary.org/obo/VSAO_0000017 TAO ...
more infohttps://bioportal.bioontology.org/ontologies/MCCL?p=classes&conceptid=http%3A%2F%2Fwww.semanticweb.org%2Fpallabi.d%2Fontologies%2F2014%2F2%2Funtitled-ontology-11%23ConnectiveTissue

Joint Meeting of the Finnish Connective Tissue and Cell Biology Societies | Suomen Solubiologit ryJoint Meeting of the Finnish Connective Tissue and Cell Biology Societies | Suomen Solubiologit ry

You are warmly welcome to the Joint Meeting of the Finnish Connective Tissue and Cell Biology Societies, which will be held on ... Etusivu › Ajankohtaista › Ajankohtaista › Joint Meeting of the Finnish Connective Tissue and Cell Biology Societies. * ... Joint Meeting of the Finnish Connective Tissue and Cell Biology Societies. 12.1.2020 ...
more infohttp://www.suomensolubiologit.fi/joint-meeting-of-the-finnish-connective-tissue-and-cell-biology-societies/

Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other...Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other...

... intensely Ia-positive dendritic cells in the interstitial connective tissues of every tissue we have examined (heart, liver, ... Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other ... Demonstration and characterization of Ia-positive dendritic cells in the interstitial connective tissues of rat heart and other ... The cell was shown to be of bone marrow origin, and either the cell itself, or more probably its precursor, was shown to be ...
more infohttp://jem.rupress.org/content/154/2/347
  • In this report, the global Connective Tissue Growth Factor market is valued at USD XX million in 2017 and is expected to reach USD XX million by the end of 2025, growing at a CAGR of XX% between 2017 and 2025. (marketdeeper.com)
  • At about the fifth or sixth month the lumen of the vagina is produced by the breaking down of the central cells of the epithelium. (wikipedia.org)
  • Learn connective tissue cells quiz , online histology test 105 for distance learning, online courses. (mcqslearn.com)
  • Free histology MCQs questions and answers to learn platelets, cytoplasmic inclusions: stored food materials, nucleus, body tissues, connective tissue cells test for online histology techniques courses distance learning. (mcqslearn.com)
  • To examine the roles of CTGF in the ovarian paracrine system, we studied rat granulosa cell CTGF gene expression both in vitro and in vivo . (endocrine-abstracts.org)
  • Studies of in vivo ovarian CTGF expression in FSH-beta knockout mice by Northern blot and in situ hybridization analyses demonstrated high levels of CTGF expression in the granulosa cells of preantral follicles blocked from further development owing to the absence of FSH. (endocrine-abstracts.org)
  • Ex vivo treatment of whole islets with recombinant human CTGF induces β-cell replication and gene expression changes consistent with those observed in vivo, demonstrating that CTGF acts directly on islets to promote β-cell replication. (diabetesjournals.org)
  • Identification of novel factors that enhance β-cell proliferation and mass regeneration in vivo while retaining optimal function would serve as an ideal strategy for remediation of all forms of diabetes. (diabetesjournals.org)
  • Understanding the underlying mechanisms or signaling pathways would move us closer to in vivo β-cell mass regeneration as a therapy. (diabetesjournals.org)
  • Our in vivo and in vitro data supports the notion that CTGF expression in mesenchymal cells in the skin and lungs can cause changes in the differentiation program of adjacent epithelial cells. (biologists.org)
  • Two chapters, "The Use of Cell Culture for the Study of Connective Tissue Cell," and "The Nature of the Fibroblast," lacked coherence and made a limited contribution. (annals.org)
  • The research, led by Professor Douglas Fearon, determined that this barrier is created by a chemokine protein, CXCL12, which is produced by a specialised kind of connective tissue cell , called a carcinoma-associated fibroblast, or CAF. (thefreedictionary.com)
  • They were labelled by the monoclonal antibodies RFD7 and anti-Leu M3 (markers of the macrophage cell line) but gave a negative reaction for the fibroblast marker IIG10 and showed no alkaline phosphatase activity. (bmj.com)
  • Shiwani Moghe, a graduate student at Texas Woman's University, decided to evaluate whether blueberry polyphenols play a role in adipocyte differentiation, the process in which a relatively unspecialized cell acquires specialized features of an adipocyte, an animal connective tissue cell specialized for the synthesis and storage of fat. (thefreedictionary.com)
  • The facts that immunoblotting showed that the antiserum crossreacted with the a subunit and that placental macrophages did not stain strongly for the b subunit also indicate that this antigen is not present in adult connective tissue cells. (bmj.com)
  • with choices mast cell and macrophages, plasma cells, leukocytes and all of above with problems solving answer key to test study skills for online e-learning, formative assessment and jobs' interview preparation tips, study connective tissues multiple choice questions based quiz question and answers. (mcqslearn.com)
  • The finding that PDGF receptor expression is induced in conjunction with the chronic synovial inflammation associated with rheumatoid arthritis and some other forms of arthritides suggests that PDGF may play a role in the stimulation of mesenchymal cell proliferation that often accompanies chronic inflammatory disease. (elsevier.com)
  • Lung fibrosis was associated with a marked increase in cells co-expressing epithelial and mesenchymal markers in the lesional and unaffected lung tissue of Col1a2-CTGF mice. (biologists.org)
  • 2.5 kb CTGF mRNA, determined by Northern analysis, but had low levels of aromatase enzyme activity (an index of granulosa cell differentiation). (endocrine-abstracts.org)
  • Our results show that CTGF gene expression in granulosa cells is inversely related to the degree of cellular differentiation, and inhibited by FSH via cAMP-mediated intracellular signalling. (endocrine-abstracts.org)
  • The quality of the epidermis can also be altered by various disease states which influence the rate of cell division and the quality of cell differentiation. (siumed.edu)
  • The aim of the present study was to investigate the effect of oxidative stress from the lipid messenger ceramide on CTGF secretion from human RPE cells. (arvojournals.org)
  • TA (10 nM, 1 μM, or 100 μM) was added to ARPE19 cells exposed to oxidative stress induced by hypoxia-reoxygenation and paraquat. (arvojournals.org)
  • Oxidative stress induced mRNA expression of VEGF, CTGF, and TGF-β by RPE cells. (arvojournals.org)
  • Tube formation by HUVECs was strongly inhibited by exposure to conditioned medium from oxidative stress-stimulated ARPE19 cells treated with 1 μM TA compared with cells not treated with TA. (arvojournals.org)
  • TA reduced VEGF expression and induced CTGF expression in ARPE19 cells exposed to oxidative stress, and conditioned medium from these cells inhibited tube formation by HUVECs. (arvojournals.org)
  • Exosomes, stained with either PKH26 or purified from CCN2-GFP-transfected cells, were taken up by activated or quiescent HSC resulting in CCN2-GFP delivery, as shown by their direct addition to recipient cells or by the GW4869-dependency of donor HSC. (sigmaaldrich.com)
  • Importantly, other ovarian expressed TGF-beta superfamily members (GDF-9 and activin, 10 ng/ml) stimulated granulosa cell CTGF mRNA in a similar fashion to TGF-beta1 (10 ng/ml), and this was also inhibited by FSH (10 ng/ml). (endocrine-abstracts.org)
  • We discovered that in embryos CTGF is necessary for β-cell proliferation, and increased CTGF in β-cells promotes proliferation of immature (MafA − ) insulin-positive cells. (diabetesjournals.org)
  • CTGF overexpression, under nonstimulatory conditions, does not increase adult β-cell proliferation. (diabetesjournals.org)
  • In this study, we tested the ability of CTGF to promote β-cell proliferation and regeneration after partial β-cell destruction. (diabetesjournals.org)
  • β-Cell mass reaches 50% recovery after 4 weeks of CTGF treatment, primarily via increased β-cell proliferation, which is enhanced as early as 2 days of treatment. (diabetesjournals.org)
  • CTGF treatment increases the number of immature β-cells but promotes proliferation of both mature and immature β-cells. (diabetesjournals.org)
  • Thus, CTGF can induce replication of adult mouse β-cells given a permissive microenvironment. (diabetesjournals.org)
  • Our laboratory showed that CTGF is required for β-cell proliferation during embryogenesis and that transgenic overexpression of CTGF in embryonic insulin-producing cells increases β-cell proliferation and mass ( 14 ). (diabetesjournals.org)
  • In contrast, induction of CTGF in adult β-cells, under normal conditions, does not increase β-cell proliferation or mass ( 15 ). (diabetesjournals.org)
  • However, CTGF is re-expressed in adult β-cells during pregnancy and in response to HFD feeding ( 13 ) (R.E. Mosser and M. Gannon, unpublished observations), suggesting that it plays a role in β-cell compensation during known periods of β-cell mass expansion. (diabetesjournals.org)
  • In addition to an expansion of the dermal compartment in Col1a2-CTGF transgenic mice, the epidermis was characterized by focal hyperplasia and basal cells stained positive for αSMA, Snail, S100A4 and Sox9, indicating that these cells had undergone a change in their genetic program. (biologists.org)
  • The scientists then inserted four specific genes into the cells. (missouri.edu)
  • The next step is for Roberts and his team to remove the four genes that reprogrammed the original cells. (missouri.edu)
  • Adult β-cell mass adapts to changing physiological demands, such as pregnancy and obesity ( 1 ). (diabetesjournals.org)
  • 6. The method of claim 1, wherein said single ESCs are obtained by enzymatically and/or mechanically dissociating said embryonic stem cells. (patentsencyclopedia.com)
  • 16. The method of claim 5, wherein a first passage of said passaging is effected no more than 10 days following initial culturing of cells of said embryoid bodies or said single embryonic stem cells in said culture medium which comprises dexamethasone and/or ascorbic acid. (patentsencyclopedia.com)
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  • The adipocytes are connective tissue cells that are specialised in storing fat (lipid). (biology-online.org)
  • Bhanu Telugu, a post-doctoral fellow in animal sciences in the MU College of Agriculture, Food and Natural Resources and a researcher in the Bond Life Sciences Center, studies stem cells created from connective tissue cells of the pig. (missouri.edu)
  • Other important initial projects for PMC will include the establishment of an international tissue bank, the development of intraoperative cryotherapy (freezing), initiation of a stromal cell modification project (stromal cells are the connective tissue cells of any organ) and the identification of a predictive model for drug prevention of malignant pleural mesothelioma. (thefreedictionary.com)
  • Blood cells are the cellular elements of blood . (biology-online.org)
  • They include the leukocytes (white blood cells) and the erythrocytes (red blood cells). (biology-online.org)
  • Right now, we researchers have not answered questions concerning how to make stem cells develop into just one type of cell, such as those of liver, kidney or blood cells, rather than a mixture," Roberts said. (missouri.edu)
  • In contrast, tissue from synovitis with prominent neovascularization showed a strong staining in the tunica media of the proliferating blood vessels as well as on connective tissue cells in the stroma. (elsevier.com)
  • Some also include the blood in this group of tissues. (bioontology.org)
  • Eberth's perithelium": an incomplete layer of connective tissue cells encasing the blood capillaries. (wikipedia.org)
  • Side effects such as tumor development, a lack of an effective and long-term animal model to test new therapies, and genetic incompatibility between the host and donor cells are some of the problems faced by researchers. (missouri.edu)
  • The cells were negative for surface immunoglobulin and the W3/13 antigen, but positive for the leukocyte common antigen and the SD (Class I) antigens of the major histocompatibility complex. (rupress.org)
  • The doses of TGF-β and C2 ceramide used in the present study had no appreciable effect on the viability of RPE cells by MTTassay. (arvojournals.org)
  • Non-inflamed synovial tissue showed no staining, indicating that PDGF receptor expression is low or absent in normal tissue. (elsevier.com)
  • It is necessary to include a margin of normal tissue around the tumor to allow for uncertainties in daily set-up and internal tumor motion. (wikipedia.org)
  • Paraffin embedded sections of human liver, lymph node, and placenta showed that certain connective tissue cells were positive for factor XIII subunit a. (bmj.com)
  • After overnight incubation with DMEM containing 0.5% FBS, cells were treated with 8 ng/ml recombinant human (rh) TGF-β for 24 h. (arvojournals.org)
  • Jump rustier and ideal draw your employees conscious capitalism book free download kitted PLEIAD or connective tissue quiz pdf stationary. (dijonlive.tk)
  • The cell was shown to be of bone marrow origin, and either the cell itself, or more probably its precursor, was shown to be sensitive to irradiation and to cyclophosphamide. (rupress.org)