Tumors or cancer of the CONJUNCTIVA.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Neoplasms containing cyst-like formations or producing mucin or serum.
Tumors or cancer of the SKIN.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Tumors or cancers of the KIDNEY.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Tumors or cancer of the THYROID GLAND.
Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.
An educational process that provides information and advice to individuals or families about a genetic condition that may affect them. The purpose is to help individuals make informed decisions about marriage, reproduction, and other health management issues based on information about the genetic disease, the available diagnostic tests, and management programs. Psychosocial support is usually offered.
Chemicals administered to patients in order to diagnose or study the pathology of medical conditions, diseases, or syndromes.
The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.
The ability to understand the nature and effect of the act in which the individual is engaged. (From Black's Law Dictionary, 6th ed).
Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.
Behaviors expressed by individuals to protect, maintain or promote their health status. For example, proper diet, and appropriate exercise are activities perceived to influence health status. Life style is closely associated with health behavior and factors influencing life style are socioeconomic, educational, and cultural.
Extracorporeal ULTRAFILTRATION technique without HEMODIALYSIS for treatment of fluid overload and electrolyte disturbances affecting renal, cardiac, or pulmonary function.
Tumors or cancer of the LIVER.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.
Excision of all or part of the liver. (Dorland, 28th ed)
Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.
Prospective patient listings for appointments or treatments.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.
An involuntary movement or exercise of function in a part, excited in response to a stimulus applied to the periphery and transmitted to the brain or spinal cord.
Diseases affecting the eye.
Tumors or cancer of the EYE.
A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
Misalignment of the visual axes of the eyes. In comitant strabismus the degree of ocular misalignment does not vary with the direction of gaze. In noncomitant strabismus the degree of misalignment varies depending on direction of gaze or which eye is fixating on the target. (Miller, Walsh & Hoyt's Clinical Neuro-Ophthalmology, 4th ed, p641)
Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.
Procedures used to reconstruct, restore, or improve defective, damaged, or missing structures.
Polymeric materials (usually organic) of large molecular weight which can be shaped by flow. Plastic usually refers to the final product with fillers, plasticizers, pigments, and stabilizers included (versus the resin, the homogeneous polymeric starting material). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The branch of surgery concerned with restoration, reconstruction, or improvement of defective, damaged, or missing structures.
A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
A nevus containing melanin. The term is usually restricted to nevocytic nevi (round or oval collections of melanin-containing nevus cells occurring at the dermoepidermal junction of the skin or in the dermis proper) or moles, but may be applied to other pigmented nevi.
Disorders of increased melanin pigmentation that develop without preceding inflammatory disease.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
A circumscribed stable malformation of the skin and occasionally of the oral mucosa, which is not due to external causes and therefore presumed to be of hereditary origin.
Clinically atypical nevi (usually exceeding 5 mm in diameter and having variable pigmentation and ill defined borders) with an increased risk for development of non-familial cutaneous malignant melanoma. Biopsies show melanocytic dysplasia. Nevi are clinically and histologically identical to the precursor lesions for melanoma in the B-K mole syndrome. (Stedman, 25th ed)
A tumor consisting of displaced ectodermal structures along the lines of embryonic fusion, the wall being formed of epithelium-lined connective tissue, including skin appendages, and containing keratin, sebum, and hair. (Stedman, 25th ed)
A malignant tumor composed of cells showing differentiation toward sebaceous epithelium. The tumor is solitary, firm, somewhat raised, more or less translucent, and covered with normal or slightly verrucose epidermis. It may be yellow or orange. The face and scalp are the commonest sites. The growth can be slow or rapid but metastasis is uncommon. Surgery cures most of the cases. (From Rook et al., Textbook of Dermatology, 4th ed, pp2403-4)
Neoplasms of the bony orbit and contents except the eyeball.
Tumors of cancer of the EYELIDS.
A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)
The mucous membrane that covers the posterior surface of the eyelids and the anterior pericorneal surface of the eyeball.
A mucosal tumor of the urinary bladder or nasal cavity in which proliferating epithelium is invaginated beneath the surface and is more smoothly rounded than in other papillomas. (Stedman, 25th ed)
A small, often impalpable benign papilloma arising in a lactiferous duct and frequently causing bleeding from the nipple. (Stedman, 25th ed)
A usually benign neoplasm that arises from the cuboidal epithelium of the choroid plexus and takes the form of an enlarged CHOROID PLEXUS, which may be associated with oversecretion of CSF. The tumor usually presents in the first decade of life with signs of increased intracranial pressure including HEADACHES; ATAXIA; DIPLOPIA; and alterations of mental status. In children it is most common in the lateral ventricles and in adults it tends to arise in the fourth ventricle. Malignant transformation to choroid plexus carcinomas may rarely occur. (Adams et al., Principles of Neurology, 6th ed, p667; DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072)
The conic organs which usually give outlet to milk from the mammary glands.

Immunoglobulin VH gene expression among extranodal marginal zone B-cell lymphomas of the ocular adnexa. (1/169)

PURPOSE: Most lymphomas of the ocular adnexa are primary extranodal non-Hodgkin's lymphomas of the B-cell type, with the most common lymphoma subtype being the extranodal marginal-zone B-cell lymphoma (EMZL). Analysis of somatic mutations in the variable (V) region of the Ig heavy (H)-chain gene segment suggests that EMZL development in other locations is dependent on antigen stimulation. The purpose of this study was to analyze the presence of somatic hypermutations in clonally rearranged Ig H-chain V genes of this lymphoma entity in the ocular adnexa and to estimate whether the mutation pattern is compatible with antigen selection. METHODS: Twenty-six cases of EMZL of the ocular adnexa were diagnosed on the basis of morphology, histology, and immunohistology. A nested polymerase chain reaction (PCR) was performed on DNA extracted from paraffin sections. The isolated PCR products were sequenced and compared with published VH germline segments to determine the number of somatic mutations in the complementarity-determining region (CDR) 2 and framework (FW) region 3. RESULTS: The number of somatic mutations in the cases of EMZL varied between 0 and 24: Five cases involved 0 to 3 somatic mutations, and the remaining 21 cases involved 4 to 24 mutations. Based on the ratio of replacement (R) to silent (S) mutations in the CDR2 or FW3 regions, antigen selection seems to have occurred in 60% of ocular adnexal EMZL. The VH3 family was the most commonly expressed germline VH family (54%), followed by VH4 (23%), with biased usage of the latter. Some germline VH1 genes used included DP-8, DP-10, DP-53, DP-63 (VH4.21), and DP-49, which are frequently used by autoantibodies (e.g., rheumatoid factors) and natural autoantibodies. CONCLUSIONS: EMZLs of the ocular adnexa have an Ig H-chain mutation pattern that supports the concept that they represent a clonal expansion of post-germinal-center memory B-cells in most instances. In two thirds of cases, antigen selection may have occurred, and autoantibodies may have a role in their development.  (+info)

Intraepithelial and invasive squamous cell carcinoma of the conjunctiva: analysis of 60 cases. (2/169)

AIM: To evaluate the clinical features, treatment results, and recurrence rates in patients with either intraepithelial or invasive squamous cell carcinoma of the conjunctiva. METHODS: Retrospective analysis of 60 cases (22 conjunctival intraepithelial and 38 invasive squamous cell carcinomas) to determine patterns of clinical presentation, aetiological factors, and treatment results. The mean patient age was 64 years old. 70% of the patients were male. Patients were treated with a variety of therapies, depending on the degree of tumour involvement; most cases were treated with frozen section controlled excision and adjunctive cryotherapy. Modified eye wall resection or enucleation was done for intraocular invasion and exenteration was done for orbital involvement. RESULTS: Red eye (68%) and ocular irritation (57%) were the most common presenting symptoms. 44% of the patients had other eye findings consistent with extensive solar exposure. 20% of the patients had a history of malignant skin tumours. Visceral malignancies developed in 8%. Scleral involvement was present in 14 (37%), intraocular involvement in five (13%), and orbital invasion in four (11%) cases with invasive squamous cell carcinoma. After a mean follow up of 56 months (18-226 months) the rate of new or recurrent tumours was 4.5% for intraepithelial squamous carcinoma and 5.3% for invasive squamous cell carcinoma. No patient developed metastases or tumour related deaths. CONCLUSION: Excision with intraoperative control of the surgical margins and adjunctive cryotherapy results in good tumour control rates.  (+info)

Conjunctival squamous cell carcinoma in Tanzania. (3/169)

AIMS: To assess changes in incidence of conjunctival squamous cell carcinoma over a 22 year period in Tanzania and to analyse possible reasons for change. METHODS: Retrospective analysis of records from a Tanzanian pathology department serving north and central Tanzania from 1976 to 1997; medical record analysis of cases of conjunctival squamous cell carcinoma presenting in the last 2 years of the study. RESULTS: There was a sharp rise in the incidence of conjunctival squamous cell carcinoma in the last 3 years of the study (1995-7). The mean age of patients presenting with the condition over the full period was 44.7 years (95% confidence interval 42.4-46.9 years). In the final 2 years of the study the mean length of history on presentation was 3.1 months (2.1-4.0 months). Several patients had a previous history of chronic conjunctival disease such as allergic conjunctivitis and trachoma; one had had a conjunctival papilloma excised previously. Only five patients had been tested for HIV status, but of these four were positive. CONCLUSION: Tanzania is experiencing an epidemic of conjunctival squamous cell carcinoma similar to that seen in other African countries. Often the tumours are aggressive and occur in patients of relatively young age. The epidemic appears to be related to HIV infection, on a background of ultraviolet light exposure. Previous chronic conjunctival disease and exposure to human papillomavirus may also have a role.  (+info)

Conjunctival MALT lymphoma: an usual cause of red eye. (4/169)

We describe a patient presenting with a red eye who was found to have conjunctival non-Hodgkin's lymphoma of the mucosa-associated lymphoid tissue (MALT) type.  (+info)

Treatment of conjunctival squamous cell carcinoma with topical 5-fluorouracil. (5/169)

AIM: To evaluate the efficacy of topical 5-fluorouracil (5-FU) alone, without concurrent surgery or radiotherapy, for the treatment of conjunctival squamous cell carcinoma. METHODS: Eight patients affected by conjunctival squamous cell carcinoma (three recurrent cases, three incompletely excised, and two untreated cases) were treated with 1% 5-FU eye drops. Topical 1% 5-FU was administered four times daily for 4 weeks (one course). Clinical examination (biomicroscopy and photography) and morphological evaluation of conjunctival cytological specimens were used to monitor the efficacy of local chemotherapy, side effects, and recurrences. RESULTS: All patients showed clinical regression of conjunctival carcinoma after topical 1% 5-FU treatment. Neoplastic conjunctiva was completely replaced by normal epithelium within 3 months. Mean follow up was 27 months. One patient needed two courses of local chemotherapy for recurrent disease. An acute transient toxic keratoconjunctivitis was observed in all treated cases; it was easily controlled with topical therapy. No long term side effects were found. CONCLUSIONS: Topical 1% 5-FU is effective in the treatment of recurrent, incompletely excised, and selected untreated conjunctival squamous cell carcinomas. Topical 1% 5-FU has no major complications. This study suggests that topical conjunctival chemotherapy with 1% 5-FU may be useful, at least as adjunctive therapy, in the treatment of conjunctival squamous cell carcinoma.  (+info)

Indeterminate melanocytic proliferations of the conjunctiva. (6/169)

PURPOSE: The purpose of this study is to test the hypothesis that a subset of conjunctival melanocytic proliferations exists that cannot be reproducibly classified as benign, malignant, or indeterminate. METHODS: Three groups of excisional biopsy specimens of conjunctival melanocytic proliferations were evaluated by 5 ophthalmic pathologists. These groups included lesions that were considered by the authors to represent benign (Group 1, n = 5), malignant (Group 2, n = 5) and indeterminate melanocytic proliferations (Group 3, n = 5). The panel classified the same sections in all 3 groups in a randomized, masked fashion, first without and then with a clinical history of patient age, sex and race. The kappa statistic (k) was used to quantify the degree of agreement among observers. RESULTS: There was strong concordance among the panel for both Group 1 (benign, k = 0.76) and Group 2 (malignant, k = 0.70) melanocytic proliferations. There was no concordance of the panel for Group 3 (indeterminate) lesions (k = -0.045). The concordance for Groups 1 and 2 and lack of concordance for Group 3 lesions were independent of knowledge of clinical history of age, sex, and race. CONCLUSIONS: A subset of melanocytic proliferations of the conjunctiva exists that cannot be reproducibly classified by pathologists as benign, malignant, or indeterminate.  (+info)

Combined nevi of the conjunctiva. (7/169)

PURPOSE: To report the clinical and histologic features of combined nevi of the conjunctiva, a type of nevus that is not uncommon in the skin but has rarely been reported in the conjunctiva. METHODS: Conjunctival nevi and melanomas from the files of the University of California, San Francisco, eye pathology laboratory were reviewed from 1984 to 1999 for the presence of features of both standard nevocytic nevi and blue nevi. Clinical histories and, when available, clinical photographs were obtained. RESULTS: Thirty-one combined nevi were discovered during the 15-year period between 1984 and 1999. One case before 1984 had been incorrectly diagnosed as a junctional nevus. The dendritic and spindle-shaped blue nevus cells had been overlooked because they were not recognized as distinct from the standard nevocytic nevus cells. The recognition of a blue as well as a brown color, a deep as well as a superficial component in the lesion, or a history of pigmentation since birth may help to establish the correct clinical diagnosis and prevent an unnecessarily deep surgical resection. Although growth of the lesion or "satellites" in some patients may favor a clinical diagnosis of melanoma, none of the lesions in this series were malignant. CONCLUSION: Despite a paucity of reports of combined nevi of the conjunctiva in the medical literature, this type of nevus--a combination of a nevocytic and a blue nevus--is common and has been overlooked in the past.  (+info)

Evaluation of ocular tumors with technetium-99m-MIBI: planar pinhole technique or SPECT? (8/169)

OBJECTIVE: This study compares 2 imaging protocols, planar pinhole technique (PPHT) and SPECT, for evaluating ocular masses with 99mTc-MIBI. METHODS: Sixteen patients with ocular lesions were studied. Planar images were acquired 10 min after the injection of 740 MBq 99mTc-MIBI with an LFOV camera fitted with a pinhole collimator (5.0 mm). A SPECT study was performed immediately after the planar study, using a 360 degrees orbit, 64 steps, 20 s/stop, a 128 x 128 matrix, and a low-energy high-resolution (LEHR) collimator. Twelve lesions (9.5-18.0 mm) proved to be malignant: 8 primary tumors (ocular melanoma); 3 local relapses of different tumors of the conjunctiva; and 1 ocular metastasis from breast cancer. The remaining 4 lesions (10.0-16.0 mm) were benign: 1 inflammatory lesion; 1 benign intraocular calcification; and 2 naevi. RESULTS: SPECT images showed 11 of 12 malignant lesions (91.6%), whereas the planar technique demonstrated only 4 of the 12 lesions (33.3%). One false-positive result, the inflammatory lesion, was visualized by both techniques. The remaining benign lesions were not detected with either method. CONCLUSION: Technetium-99m-MIBI SPECT is a sensitive technique for detecting malignant ocular tumors. SPECT imaging is a better alternative to planar imaging for ocular tumors.  (+info)

a) What is conjunctival melanoma? Melanomas are tumours which come from pigmented cells in our body. As well as growing on the skin, they can grow on the conjunctiva of the eye. Conjunctival melanoma accounts for 2% of eye cancers. It arises most commonly form primary acquired melanosis, or from a naevus (freckle) already present on the eye. Least commonly it arises on its own; this is known as primary conjunctival melanoma. This cancer can spread to other organs in the body, most commonly, the liver.. b) What does conjunctival melanoma look like?. Conjunctival melanoma looks like an uneven, raised, grey or pink lump growing on white conjunctiva or from a pigmented area on the conjunctiva. This may cause irritation and watering from the eye.. c) What are the risks of getting conjunctival melanoma?. The following increase your risk of developing conjunctival melanoma:. • Having pale skin. • Red or blond hair. • Blue eyes. • Over 50 years of age. • Large number of moles or ...
The relationship between Human Papillomavirus (HPV) infection and conjunctiva cancer is controversial. HPV detection will provide more information about the role of this infectious agent in the biology of conjunctiva cancer. In the present study, DNA extracted and purified from 36 Conjunctival Squamous Cell Carcinomas (CSCC) was evaluated by PCR for HPV DNA sequences. The results were correlated with the clinical and histopathological variables. The results showed that HPV DNA was present in 8 CSCC samples (22%); HPV16 was the sole type detected. Significant association was found between HPV detection and the limbus tumor subtype (p = 0.03). All the samples were non-metastatic squamous cell carcinoma. The HPV presence in CSCC from Mexican patients is not a common event.
As part of a larger investigation of cancer in Uganda, we conducted a case-control study of conjunctival squamous cell carcinoma in adults presenting at hospitals in Kampala. Participants were interviewed about social and lifestyle factors and had blood tested for antibodies to HIV, KSHV and HPV-16, -18 and -45. The odds of each factor among 60 people with conjunctival cancer was compared to that among 1214 controls with other cancer sites or types, using odds ratios, estimated with unconditional logistic regression. Conjunctival cancer was associated with HIV infection (OR 10.1, 95% confidence intervals [CI] 5.2-19.4; P|0.001), and was less common in those with a higher personal income (OR=0.4, 95% CI 0.3-0.7; P|0.001)[corrected]. The risk of conjunctival cancer increased with increasing time spent in cultivation and therefore in direct sunlight (chi2 trend=3.9, P=0.05), but decreased with decreasing age at leaving home (chi2 trend=3.9, P=0.05), perhaps reflecting less exposure to sunlight consequent
An electron microscopic study was performed on a conjunctival squamous cell carcinoma in an 82-year-old man. Biopsies were taken before and during beta-irradiation and the morphologic features of nonirradiated tumor cells were compared to those after application of 10,000 rad. There occur striking changes in the nucleus and the cytoplasm after irradiation. The nuclei show hypertrophic and electron-dense nucleoli as well as altered chromatin structures. The cytoplasm of many cells appears destroyed and contains numerous vacuole-like structures, as well as swollen mitochondria. It is of interest that numerous normal lymphoid cells were present within the irradiated tumor.
The incidence of conjunctival melanoma is about 0.2-0.8/1 000 000 cases each year.1 2 As a consequence our knowledge about this tumour is limited, but cell lines derived from these tumours will give more information about them. So far only three conjunctival melanoma cell lines have been described.3 4 The first cell line, IPC 292, was described in 1993 by Aubert et al.4 Recently, Nareyeck et al developed two additional conjunctival melanoma cell lines (CRMM1 and CRMM2).3 We wish to report a further, fourth, conjunctival melanoma cell line, CM2005.1.. The conjunctival melanoma cell line CM2005.1 was established from tumour material derived from a 84-year-old male. The primary tumour was located at the medial side of the inner ...
Two hundred and seventeen cases were diagnosed clinically as PT (91.13%) and 21 as P (9.87%); 56.54% of all P/PT patients were male. The average age at diagnosis was 53.4±15.54 years. The overall incidence of OSSN in these P/PT cases was 6.65% (P: 19.04% PT: 5.55%); 56.25% of this cohort were female. The average age of patients with P/PT and OSSN was similar to non-OSSN P/PT patients (P,0.05). The OSSN were diagnosed as conjunctival intraepithelial neoplasia (CIN) I (68.75%), CIN II (12.5%), CIN III (12.5%), and actinic keratosis (6.25%). ML included one primary acquired melanosis without atypia and one with mild atypia (a 41-year old woman and a 60-year old male, respectively).. ...
Purpose : The role of Human papilloma virus (HPV) in ocular surface squamous neoplasia (OSSN) from HIV sero-positive (HSP) patients is controversial. Our hypothesis was that OSSN in HSP patients would be driven by HPV and thus would demonstrate p16 expression, a well-established biomarker of HPV-associated squamous neoplasms. We studied the hypothesis by retrospectively surveying OSSN from a large HIV sero-positive cohort from Mozambique. Methods : A total of 75 patients from Mozambique were selected. Forty-seven were female and 28 were male. The age ranged from 21 to 70. Formalin fixed, paraffin-embedded tissue blocks from biopsies and resections were cut and stained with hematoxylin and eosin (H&E). We reviewed the H&E slides and assigned diagnoses. All cases were evaluated with p16 immunohistochemistry. Cases were classified as positive when the neoplastic cells showed strong nuclear and cytoplasmic expression. These cases were further subdivided by HIV status, diagnosis, gender, and age and ...
TY - JOUR. T1 - Role of high resolution optical coherence tomography in diagnosing ocular surface squamous neoplasia with coexisting ocular surface diseases. AU - Atallah, Marwan. AU - Joag, Madhura. AU - Galor, Anat. AU - Amescua, Guillermo. AU - Nanji, Afshan. AU - Wang, Jianhua. AU - Perez, Victor L.. AU - Dubovy, Sander. AU - Karp, Carol L.. N1 - Funding Information: Supported by the NIH Center Core Grant P30EY014801 , RPB Unrestricted Award and Career Development Awards, Department of Defense (DOD- Grant# W81XWH-09-1-0675 ), Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Clinical Sciences Research EPID-006-15S (Dr. Galor), The Ronald and Alicia Lepke Grant, The Lee and Claire Hager Grant, The Jimmy and Gaye Bryan Grant, The Azar Family Grant, The Robert Baer Family Grant, The Gordon Charitable Foundation, The H. Scott Huizenga Grant, The Grant and Diana Stanton-Thornbrough Grant, The Mark Feldberg Family Grant, and supported in part by an ...
There are problems with many of the studies investigating the possible causes of CIN. They vary significantly in terms of study design, quality, consistency and directness.. A small number of eyes have been examined in the majority of the studies. This could be because this condition is rare, and it was very rare until recently. Most of the researchers have attempted to match cases and controls in terms of age and sex in an attempt to reduce the numbers of confounding factors and gain results with the highest statistical significance. As Napora et al7 explained, case-control studies permit the investigation of multiple exposures and are therefore appropriate for the study of relatively rare diseases.. The data on sun exposure are largely based on studies of SCC. Newton et al21 showed evidence of a dose-response gradient. There are, however, likely to be multiple confounding factors in their interpretation of the difference in incidence of SCC in Uganda and the United Kingdom. They have ...
Conjunctival melanoma is a relatively rare malignancy. It is usually a pigmented, unilateral lesion, often in the perilimbal interpalpebral bulbar conjunctiva, mostly arising from primary acquired melanosis. An 81-year-old male,...
ENCODES a protein that exhibits metalloendopeptidase activity (inferred); metallopeptidase activity (inferred); INVOLVED IN binding of sperm to zona pellucida; fertilization; flagellated sperm motility; ASSOCIATED WITH impaired binding of sperm to zona pellucida; impaired fertilization; male infertility; ASSOCIATED WITH brain glioma (ortholog); conjunctival squamous cell carcinoma (ortholog); Hepatomegaly (ortholog); FOUND IN cell surface; membrane raft; plasma membrane; INTERACTS WITH 1,2-dichloroethane; 3,4-methylenedioxymethamphetamine; bis(2-chloroethyl) sulfide
Studies of the aetiology and pathogenesis of conjunctival melanoma have been hampered by the rarity of the disease resulting in many investigations analysing a limited number of patient samples. Despite this several genetic studies have revealed the presence of frequent BRAF mutation; in addition, the common, non-random genetic abnormalities of chromosomes 3, 6 and 8, that occur in uveal melanomas, are not found in conjunctival melanoma suggesting, a more similar pathogenesis to cutaneous melanoma. Studies performed by LOORG demonstrated common amplification of CDKN1A and RUNX2 in primary conjunctival melanomas. In metastases amplification of MLH1, TIMP2 and chromosome 20q were also common in addition to deletion of MGMT and ECHS1 ...
PURPOSE: To report the application of a novel imaging technique, pump-probe microscopy, to analyze patterns of pigment chemistry of conjunctival melanocytic lesion biopsies. METHODS: Histopathologic specimens of eight previously excised conjunctival melanocytic lesions were analyzed with pump-probe microscopy. The technique uses a laser scanning microscope with a two-color pulsed laser source to distinguish hemoglobin, eumelanin, and pheomelanin pigment based on differences in transient excited state and ground state photodynamics. The pump-probe signatures of conjunctival melanins were compared with cutaneous melanins. The distributions of hemoglobin, eumelanin, and pheomelanin were analyzed, and pump-probe images were correlated with adjacent hematoxylin and eosin (H&E)-stained sections. RESULTS: The pump-probe signatures of conjunctival melanins are similar, but not identical to cutaneous melanins. In addition, there are qualitative and quantitative differences in the structure and pigment ...
Dr. Finger introduces and describes conjunctival tumors. What are they, and are there causes, symptoms, and/or treatments for this cancer?
Numerous other conditions may present in a similar fashion, including trachoma, cicatricial conjunctivitis secondary to chronic topical medications (especially pilocarpine, phospholine iodide and antiviral agents), chemical burn, and radiation treatment. In addition to the entities mentioned above, the possibility of a malignant process (eg, conjunctival intraepithelial neoplasia and squamous cell carcinoma) should always be considered, particularly in older patients with risk factors ...
Ocular surface squamous neoplasia treatment. ■ Acupuncture as treatment for glaucoma. ■ Punctal plug retention rates in treatment of dry eye. ■
Trans conjunctival cyst excision Soosan Jacob verrugas de papiloma en la cara Hpv genitalwarzen behandlung papilloma virus effetto sugli uomini, infeccion por virus papiloma humano sintomas hormonal cancer what is. Oocyte activation.
The method used for the detection of HPV was real time polymerase chain reaction. Infectia nefiind legata de modalitatea de parturitie.
Scopurile tratamentului sunt de a distruge negii și papiloamele și de a stimula răspunsul sistemului imunitar al organismului împotriva virusului. Si as mai dori sa aflu de ce sotul meu, avind relatii sexuale cu mine, nu prezinta nici un simptom de Herpes Simplex? Conjunctival papillomas schimb, infectiile genitale transmise sexual si papiloamele laringeale sint de mare importanta clinica.
Caracterul cameleonic al virusului HPV reflecta durata conjunctival papilloma a infectiei HPV si reinfectia secventiala prin noi parteneri.
All other ophthalmological findings were normal. Negii sunt formaţiuni benigne, dar extrem de neplăcute. Excisional Biopsy of Pigmented Conjunctival Lesion hpv by mouth Papilloma virus dolore pelvico ombladon cheia de sub pres, abdominal cancer symptoms male cancer de prostata ciclo de krebs.
Primary conjunctival malignant melanomas that arise from junctional or compound nevi are probably analo- gous to the cutaneous superficial spreading malignant melanoma.1987).
Seward County Community College observed its annual service awards Monday, with 30 employees receiving recognition for years in education.. This is a celebration of why our work matters, said SCCC President, Dr. Ken Trzaska. As days and years in our work pass, we are achieving something meaningful.. Special guest, Liberal Area Chamber of Commerce director Rozelle Webb presented instructor Russ Reglin with the 2017/18 Teacher of the Year award from the Chamber.. The whole town of Liberal admires SCCC for what it does, she said. The college provides an excellent education to our youth as well as people across the community, and that is because of its excellent instructors.. Instructor Cody Pickering received an award from the Cimarron Valley Veterans and First Responders group, in recognition of his many years of work as a volunteer.. Members of the SCCC Executive team - Vice President of Finance and Operations Dennis Sander, Vice President of Student Services Celeste Donovan, Vice ...
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The recommended CCSDS 131.2-B-1 standard introduces a Serial Concatenated Convolutional Code (SCCC). Main goal of this code is to allow an efficient use ...
SCCC provides support for housing, next steps As the COVID-19 pandemic unfolds, its impact is felt by student-athletes who rely on collegiate athletics to guide their course. In concert with its national and state governing bodies (NJCAA and KJCCC), Seward… Read More ›. ...
Dormant or slow-cycling tumor cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery and adjuvant therapy. We have adapted the pulse-chase expression of H2BeGFP for labeling and isolating slow-cycling cancer cells (SCCCs). SCCCs showed cancer initiation potential and enhanced chemoresistance. Cells at this slow-cycling status presented a distinctive nongenetic and cell-autonomous gene expression profile shared across different tumor types. We identified TET2 epigenetic enzyme as a key factor controlling SCCC numbers, survival, and tumor recurrence. 5-Hydroxymethylcytosine (5hmC), generated by TET2 enzymatic activity, labeled the SCCC genome in carcinomas and was a predictive biomarker of relapse and survival in cancer patients. We have shown the enhanced chemoresistance of SCCCs and revealed 5hmC as a biomarker for their clinical identification and TET2 as a potential drug target for SCCC elimination that could extend patients ...
Dormant or slow-cycling tumor cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery and adjuvant therapy. We have adapted the pulse-chase expression of H2BeGFP for labeling and isolating slow-cycling cancer cells (SCCCs). SCCCs showed cancer initiation potential and enhanced chemoresistance. Cells at this slow-cycling status presented a distinctive nongenetic and cell-autonomous gene expression profile shared across different tumor types. We identified TET2 epigenetic enzyme as a key factor controlling SCCC numbers, survival, and tumor recurrence. 5-Hydroxymethylcytosine (5hmC), generated by TET2 enzymatic activity, labeled the SCCC genome in carcinomas and was a predictive biomarker of relapse and survival in cancer patients. We have shown the enhanced chemoresistance of SCCCs and revealed 5hmC as a biomarker for their clinical identification and TET2 as a potential drug target for SCCC elimination that could extend patients ...
A conjunctival melanocytic nevus may on occasion be difficult to distinguish from melanoma both clinically and histopathologically. An unambiguous correct diagnosis is critical because of major differences in management and prognosis. We evaluated a fluorescence in situ hybridization (FISH) assay, which has previously been shown to be of value for the diagnosis of melanocytic nevi and melanomas of the skin, using probes targeting 6p25 (RREB1), 6q23 (MYB), 11q13 (CCND1) and centromere 6 (CEP6), for its potential to assist in the distinction of conjunctival melanocytic nevi from melanomas. Four melanocytic nevi and eight melanomas of the conjunctiva were analyzed. Two of the melanomas were diagnostically problematic because of suboptimal histopathology. None of the conjunctival melanocytic nevi showed a level of chromosomal aberrations that met FISH criteria for a diagnosis of melanoma. All eight conjunctival melanomas (six unequivocal and two suspicious lesions) met FISH criteria for melanoma. ...
Cancer de laringe causas cancer de col uterin stadiul 2 b, simptome cancer colon femei definition of anthelmintic in pharmacy. Shannon Wong, MD which hpv virus causes common warts Papilloma virus e tumore-collo-utero cancer de prostata numeros, hpv virus conjunctival papillomas saliva respiratory papillomatosis in newborns. Conjunctival Nevus Excision pancreatic cancer quora E-mail: moc.
Cheapest Forzest areas Page 284 пTable -4 lesion Clinical Comparison Chaepest Youth Adulthood Youth Congenital Middle age of Conjunctival Area Small Patchy or diffuse Cheapest Forzest, cystic Patchy or diffuse Patchy or diffuse Pigmentary location Conjunctiva Conjunctiva Conjunctiva Fьrzest Conjunctiva Lesions No No Low (conjunctival melanoma) Yes (skin, conjunctival, orbital melanoma) Yes (conjunctival melanoma) Freckle Benign acquired melanosis Conjunctival nevus Ocular and oculodermal melanocytosis Primary acquired melanosis uveal, CHAPTER 11 Clinical Approach to Neoplastic Disorders. Cheapest Forzest eye movements and eye blink artifacts identification was based on the correlation between EOG electrodes andor certain EEG derivations. Key intermediates for preparation of Cheapets Cheapest Forzest antagonists. (2002) G9a CCheapest methyltransferase plays a dominant role in euchromatic his- tone H3 lysine 9 methylation and is essential for early embryogenesis.
In general, papilloma is a histopathological term describing tumors with specific morphology. They take on a classic finger like or cauliflower like appearance. Papillomatous lesions often are lobulated with a central vascular core. Irrelevant of its cytology, a neoplasm of epithelial origin with this form of growth is also called papilloma. Papillomas can be benign or malignant and can be found in numerous anatomical locations (eg, skin, conjunctiva, cervix, breast duct). Specifically, conjunctival papillomas are benign squamous epithelial tumors with minimal propensity toward malignancy.
Treatment: In general a biopsy is required for proper diagnosis of PAM. A biopsy yields prognostic information. If the lesion is small complete excision may be possible on initial biopsy and that is preferred. Extirpation has been reported with topical mitomycin; chemotherapy was found to induce regression of conjunctival melanoma and primary acquired melanosis with atypia. Cryotherapy, laser ablation, and radiation may be indicated to treat large areas of affected conjunctiva and thus spare patients the potential complications of symblepharon and dry eye associated with large conjunctiva excision. Exenteration of the orbit is not indicated for PAM, a condition that by definition is entirely intraepithelial. Often PAM exists for many years and patients undergo many biopsies ...
In addition to providing complete descriptions of the tumors and tumor-like lesions in the various compartments of the eye and ocular adnexa, the authors correlate the pathologic features with epidemiologic and pathogenetic observations, clinical features, differential diagnosis, and special studies including immunohistochemistry and various molecular approaches. Each anatomic site has a section on normal anatomy and histology, and there is a separate chapter on the pathologic examination of ocular specimens, so that the general pathologist can approach these uncommonly encountered specimens with confidence. Because of its scholarly, practical, well illustrated and well referenced approach, this work will appeal to pathologists and ophthalmologists alike ...
Read the AMA CPT® Assistant newsletter article titled: Surgery-Eye and Ocular Adnexa (August 2009) - Subscription required
Synonyms for conjunctiva in Free Thesaurus. Antonyms for conjunctiva. 16 words related to conjunctiva: eye, oculus, optic, eyelid, lid, palpebra, bulbar conjunctiva, conjunctival layer of bulb, tunica conjunctiva bulbi.... What are synonyms for conjunctiva?
The marginal zone (MZ) was originally defined as an anatomical compartment within the spleen located around primary or secondary follicles and containing B cells with distinct phenotypic and functional characteristics. The MZ of the spleen is believed to be positioned in such a way that it primarily encounters blood borne pathogens. Later, primary mucosa-associated lymphoid tissues (MALT) of e.g. Waldeyers ring, Peyers patches and appendix, locations known for a significant influx of Ags, were also found to contain a marginal zone. MZ B cells in mice and rats express essentially unmutated IgV genes and are supposed to be non-recirculating.29 On the other hand, human MZ B cells of both spleen and Peyers patches do harbor mutated IgV genes and recirculate (Figure 2).30-32 Human splenic MZ B cells are IgM IgD and co-express the B-cell markers CD20, CD22 and CD79a/b, the memory B-cell marker CD27, the complement receptors CD18/CD11b, CD21 and CD35, and the anti-apoptotic molecule BCL-2. MZ B ...
Information on MALT lymphoma, (extranodal marginal zone B-cell lymphoma) including diagnosis, treatments, possible side effects and getting support.
Orbital Oncology and Ophthalmic Plastic Surgery is a subspecialty that focuses on the surgical treatment of tumors of the eye, orbit, eyelid, conjunctiva and other ocular adnexal structures, as well as reconstructive surgery in the periocular region in cancer patients. At MD Anderson, the primary goals of this subspecialty are surgical elimination of ocular and orbital cancers while preserving the eye and vision, and restoring function and cosmesis in the periocular region.. In this subspecialty within the Plastic Surgery department, Bita Esmaeli, M.D., professor of Ophthalmology, sees approximately 350 new patients and consultations each year. Among these are patients with rare cancers of the ocular and orbital area that require multidisciplinary expertise offered by departments across MD Anderson. Specific diseases and cancers treated by physicians in this subspecialty include conjunctival tumors, eyelid cancers, lacrimal gland tumors, orbital tumors and uveal melanoma.. Dr. Esmaeli sees ...
Histopathology exam showed a moderate differentiated keratinized squamous cell carcinoma conjunctival papilloma pathology the conjunctiva without koilocytosis [Figs. He has been treated for the last 2 months with dexamethasone eye drops for scleritis by another ophthalmologist.
Papilloma histopathology method for HPV histopathology papilloma virus was immunohistochemistry for p16 protein, which is a specific capsid protein of HPV 16 type, so we cannot certify the presence of HPV genome in all specimens studied. The patient admits being a heavy smoker for almost 30 years conjunctival papilloma histology that in his free time he practices agriculture without using sunglasses. Pathology of the Vulva and Vagina introduces the topic with a stylishly illustrated description of the embryology and development which is fundamental to understanding the pathogenesis and symptomatology.
Figure 1A: Bulbar conjunctiva of the left eye imaged in a 50 degrees red-free mode with the RFI. Temporal conjunctiva of the patients left eye with microangiopa
The Flow Cytometry Shared Resource (FCSR) at the Sylvester Comprehensive Cancer Center (SCCC) provides researchers with sophisticated methods for the analysis and preparative sorting of both normal and tumor cells. The facility helps researchers measure apoptosis, gene expression, drug metabolism, immune responses and pathways of cellular activation, both normal and tumor-related. The shared resource maintains instruments, computer work-stations for data analysis and related equipment to support scientists affiliated with Sylvesters multidisciplinary research programs, as well as researchers in a wide variety of cancer-related research projects.. The facility also provides training to investigators in flow cytometric applications, mass cytometry and cell sorting technologies.. ...
If you name a club, hes in it. If there is a school event happening, hes there. Seward County Community College sophomore, Emmanuel (Manny) Serrano, is the most involved student around campus. Serrano is a Liberal native that came to SCCC after attending Fellowship Baptist School and received a scholarship from SCCC that is offered...
Conjunctiva (of the eye) - a thin delicate mucous membrane that covers the front of the eyes and also lines the insides of the eyelids. The thickness and other characteristics of the conjunctiva vary according to location across the front of these eye.
On Saturday, October 20th, counselors, alumni, staff and members of the Board gathered at SCCCs Mid-City campus to reconnect and celebrate SCCCs past, present and future. The 70s themed event paid homage to the Southern California Counseling Centers history, celebrating 1974 - the year that 6515 W. Pico Blvd. became home. SCCC Ribbon Cutting Circa 1974 A big THANK YOU to Marisa Ice for organizing the event as well as counselors Adrienne Rusk, Karly Meola, Jaclyn Lieber and Syd Peterson for their hard work in planning the day ...
Marginal Zone B-Cell Lymphoma. In: Lichtman MA, Kaushansky K, Prchal JT, Levi MM, Burns LJ, Armitage JO. Lichtman M.A., Kaushansky K, Prchal J.T., Levi M.M., Burns L.J., Armitage J.O. Eds. Marshall A. Lichtman, et al.eds. Williams Manual of Hematology, 9e New York, NY: McGraw-Hill; . http://hemonc.mhmedical.com/content.aspx?bookid=1889§ionid=137390297. Accessed January 22, 2018 ...
Mayo, R. Nair, R. Gheith, S. (2016, Sept). An Unusual Case of IgG4 Associated Marginal Zone B-cell Lymphoma Presenting as Subcutaneous Nodules Mimicking Lipomas. Poster Presented at: POSH, Harrisburg, Pa.. ...
• Seven cases of subcutaneous epithelioid granulomas caused by silica and involving the eyelids and periorbital region are described. Histologically, all cases
Topical bevacizumab administration in clinical studies: 1% (10mg/ml) bevacizumab 4 times/day; 0,5% (5 mg/ml) bevacizumab for 0,5-12 months (5 times/day), 1% topical bevacizumab for 2-4 times/day for 3 weeks. Topical 5 mg/ml 4 times daily during 8 weeks can be used as reductive treatment for squamous neoplasia of conjunctiva and cornea. Subconjunctival bevacizumab application: 2,5 mg/0,1 ml; 3 injections of 2,5 mg/0,1 ml bevacizumab. Intrastromal application: 1-2 subconjunctival詻歪쭫ꉦ� injections (1,25 mg/0,05 mL) at 1-month intervals, deep intrastromal (2,5 mg/0,1 mL) bevacizumab after deep anterior keratoplasty; 27-gauge needle 2,5 mg/0,1 ml deep intrastromal paracentral injection ...
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Bradley KT, Arber DA, Brown MS, Chang CC, Coupland SE, de Baca ME, Ellis DW, Foucar K, Hsi ED, Jaffe ES, Lill MC, McClure SP, Medeiros LJ, Perkins SL, Hussong JW. Protocol for the examination of specimens from patients with hematopoietic neoplasms of the ocular adnexa. Arch Pathol Lab Med. 2010 Mar; 134(3):336-40 ...
See a picture of and learn about transient neonatal pustular melanosis, a type of skin condition, in the eMedicineHealth Image Collection Gallery.
I have a doctor who documented 3 nevi back. 1% lido with epi anesth, #15 blade excision. Discussed wound care. Upper, mid and lower back specime
... conjunctival neoplasms MeSH C11.319.421 - eyelid neoplasms MeSH C11.319.457 - orbital neoplasms MeSH C11.319.475 - retinal ... iris neoplasms MeSH C11.941.375.385 - iritis MeSH C11.941.855 - uveal neoplasms MeSH C11.941.855.198 - choroid neoplasms MeSH ... uveal neoplasms MeSH C11.319.494.198 - choroid neoplasms MeSH C11.319.494.400 - iris neoplasms MeSH C11.338.133 - blepharitis ... MeSH C11.187.169 - conjunctival neoplasms MeSH C11.187.183 - conjunctivitis MeSH C11.187.183.200 - conjunctivitis, allergic ...
Aniridia, a developmental anomaly of the iris, disrupts the normal barrier of the cornea to the conjunctival epithelial cells ... The limbus is a common site for the occurrence of corneal epithelial neoplasm. The limbus contains radially-oriented ...
Berman JJ (November 2004). "Tumor taxonomy for the developmental lineage classification of neoplasms". BMC Cancer. 4: 88. doi: ... Conjunctival squamous cell carcinoma (conjunctival SCC) and corneal intraepithelial neoplasia comprise what are called ocular ... Treatment of conjunctival SCC is usually surgical excision followed by cryotherapy. After this procedure, Conjunctival SCC can ... Mortality for conjunctival SCC ranges from 0-8%. Diagnosis is often made by biopsy, as well as CT (in the case of invasive SCC ...
"Conjunctival Kaposi's Sarcoma - The Eye Cancer Network". Archived from the original on 2010-11-24. Retrieved 2010-03-10. " ... Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be ... "Pigmented Conjunctival Tumors - The Eye Cancer Network". Archived from the original on 2009-08-20. Retrieved 2010-03-10. " ... "General Information: Malignant Conjunctival Tumors - The Eye Cancer Network". Archived from the original on 2010-11-24. ...
"Conjunctival Kaposi's Sarcoma - The Eye Cancer Network". Retrieved 2010-03-10.. *^ "Epibulbar Dermoid - The Eye Cancer Network" ... "Pigmented Conjunctival Tumors - The Eye Cancer Network". Retrieved 2010-03-10.. *^ "Pingueculum - The Eye Cancer Network". ... Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be ... "General Information: Malignant Conjunctival Tumors - The Eye Cancer Network". Retrieved 2010-03-10.. ...
"A Transmissible Avian Neoplasm (Sarcoma of the Common Fowl)". Journal of Experimental Medicine. 12 (5): 696-705. doi:10.1084/ ... "Human Transcriptome Subtraction by Using Short Sequence Tags To Search for Tumor Viruses in Conjunctival Carcinoma". Journal ...
Eye neoplasm Carol Lally Shields Archived 2008-07-06 at the Wayback Machine biography at the University of Notre Dame Athletics ... and Atlas of Eyelid and Conjunctival Tumors. She is also co- editor of a comprehensive book entitled, "Retinoblastoma", ...
... conjunctival neoplasms MeSH C04.588.364.659 - orbital neoplasms MeSH C04.588.364.818 - retinal neoplasms MeSH C04.588.364.818. ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588.274.120.250.250 - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ... femoral neoplasms MeSH C04.588.149.721 - skull neoplasms MeSH C04.588.149.721.450 - jaw neoplasms MeSH C04.588.149.721.450.583 ...
... s represent from 10% to 25% of all intracranial neoplasms and the estimated prevalence rate in the general ... short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) - another type of ...
Neoplasm should be considered in any patient presenting with nasolacrimal duct obstruction. In patients with atypical ... the examiner instills fluorescein into the conjunctival fornices of each eye and then observes the tear film, preferably with ... Bloody punctual discharge or lacrimal sac distension above the medial canthal tendon is also highly suggestive of neoplasm. ...
... attributed to intracranial neoplasm Headache attributed to increased intracranial pressure or hydrocephalus caused by neoplasm ... tension-type headache Cluster headache Paroxysmal hemicrania Short-lasting unilateral neuralgiform headache with conjunctival ... Headache attributed directly to neoplasm Headache attributed to carcinomatous meningitis Headache attributed to hypothalamic or ...
STEWART, SE; EDDY, BE; BORGESE, N (June 1958). "Neoplasms in mice inoculated with a tumor agent carried in tissue culture". ... October 2007). "Human Transcriptome Subtraction by Using Short Sequence Tags To Search for Tumor Viruses in Conjunctival ... Rous, Peyton (1910). "A Transmissible Avian Neoplasm (Sarcoma of the Common Fowl)". Journal of Experimental Medicine. 12 (5): ...
List of human cell types derived from the germ layers Hodges, R.R.; Dartt, D.A. (2010). "Conjunctival Goblet Cells". ... McCusker, ME; Coté, TR; Clegg, LX; Sobin, LH (2002). "Primary malignant neoplasms of the appendix: a population-based study ...
Patients present with conjunctival (25% of cases) or intra-orbital (75% of cases) lesions which typically involve one eye but ... "The 2016 revision of the World Health Organization classification of lymphoid neoplasms". Blood. 127 (20): 2375-90. doi:10.1182 ... Tanenbaum RE, Galor A, Dubovy SR, Karp CL (2019). "Classification, diagnosis, and management of conjunctival lymphoma". Eye and ... in 10-15% of cases, particularly in conjunctival cases, involve both eyes. Conjunctiva lesions usually present as a salmon red ...
Gear H, Williams H, Kemp EG, Roberts F (August 2004). "BRAF mutations in conjunctival melanoma". Investigative Ophthalmology & ... a benign but locally infiltrative odontogenic neoplasm. The V600E mutation may also be linked, as a single-driver mutation (a ...
Conjunctivitis, irritation inflammation, edema, ulceration of conjunctival sacs No studies Blood No studies Decrease in RBC ... found no consistent evidence of excess risks of neoplasms that could have some link to DU, and that "[t]he overall incidence of ...
Tumors: Skin neoplasm, nevi and melanomas (C43/D22, 172/216, ICD-O 8720-8799) ...
Neoplasms. Carcinoma in Situ. Carcinoma. Neoplasms, Glandular and Epithelial. Neoplasms by Histologic Type. Interferons. ... Conjunctival Intraepithelial Neoplasia Corneal Intraepithelial Neoplasia Drug: Mitomycin C Drug: Interferon Alfa-2b Phase 4 ... Topical Interferon Alfa 2b and Mitomycin C in Conjunctival-Corneal Intraepithelial Neoplasia. The safety and scientific ... Recurrence of conjunctival-corneal intraepithelial neoplasia [ Time Frame: One year ]. Watch at least one year after the ...
Variants studied for benign conjunctival neoplasm Included ClinVar conditions (4):*Epidermal nevus syndrome ...
We have extended the concept of autologous conjunctival transplantation for corneal resurfacing as recommended by Thoft to ... neoplasms (3), degenerative diseases (5), trauma (1), and developmental anomalies (1). Large, free conjunctival grafts from ... Reconstruction of the periocular mucous membrane by autologous conjunctival transplantation Ophthalmology. 1982 Sep;89(9):1072- ... The use of free conjunctival grafts provides significant advantage over the use of buccal mucous membrane grafts. The ...
Malignant Conjunctival Neoplasm. *Melanoma (Skin). *Biological: incomplete Freund's adjuvant. *Biological: multi-epitope ... Number of Patients with Sentinel Lymph Node (SLN) Positivity in Conjunctival/eyelid Melanomas ...
"Conjunctival Kaposis Sarcoma - The Eye Cancer Network". Retrieved 2010-03-10.. *^ "Epibulbar Dermoid - The Eye Cancer Network" ... "Pigmented Conjunctival Tumors - The Eye Cancer Network". Retrieved 2010-03-10.. *^ "Pingueculum - The Eye Cancer Network". ... Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be ... "General Information: Malignant Conjunctival Tumors - The Eye Cancer Network". Retrieved 2010-03-10.. ...
Mitomycin C is effective in inducing regression of corneal conjunctival intraepithelial neoplasia. Complications are common but ... Conjunctival Neoplasms / drug therapy* * Corneal Diseases / drug therapy* * Eye Neoplasms / drug therapy ... Use of mitomycin C in the treatment of corneal conjunctival intraepithelial neoplasia Clin Exp Ophthalmol. 2002 Apr;30(2):94-8. ... Purpose: To evaluate the efficacy of topical mitomycin C as a treatment of corneal conjunctival intraepithelial neoplasia. ...
Eyelid and Conjunctival Neoplasms. Pages 423-438. Wagner, Lilly (et al.). Preview Buy Chapter $29.95 ...
Eye Neoplasms. NLM Class: WW 149. LC Class: RC280. Abstract: Written by internationally renowned experts, Clinical Ophthalmic ... In this volume, the examination techniques, classification, and differential diagnosis of eyelid tumors and conjunctival and ... Eyelid and Conjunctival Tumors : Peer, Jacob : : Books ... Clinical Ophthalmic Oncology: Eyelid and Conjunctival Tumors. ...
Conjunctival neoplasms (e.g. lymphoma) with secondary haemorrhage. Kaposis sarcoma (red or purple lesions under conjunctiva) ... Sub-conjunctival haemorrhage. Version 11. Date of search 26.02.19;. Date of revision 24.04.19;. Date of publication 10.07.19;. ... Sub-conjunctival haemorrhage. The CMGs are guidelines on the diagnosis and management of a range of common and rare, but ... Sub-conjunctival haemorrhage (S-CH) is a common condition which is usually unimportant but very occasionally indicates a ...
Conjunctival squamous cell neoplasms can cause significant morbidity. Early diagnosis and intervention can prevent major eye ... Conjunctival Squamous Cell Carcinoma, A Rare Entity: Case Report of 2 Cases Nishtha Saini1, Sonia Hasija2*, Manpreet Kaur Gill1 ... Conjunctival congestion was seen and sentinel vessels were seen feeding the tumour. Visual acuity in his right eye was 6/18 and ... Squamous conjunctival carcinoma typically occurs on the bulbar conjunctiva, originating at the limbus, and often spreads onto ...
OR Conjunctival Diseases[tiab] OR CONJUNCTIVAL HAEMORRHAGE[tiab] OR Conjunctival Injury[tiab] OR CONJUNCTIVAL ULCERATION[tiab] ... OR Eye Neoplasm[tiab] OR Eye Neoplasms[tiab] OR EYE PAIN[tiab] OR Eye swelling[tiab] OR Eyelid Disease[tiab] OR Eyelid Diseases ... Development of conjunctival hyperemia with the use of a fixed combination of latanoprost/timolol: systematic review and meta- ... Conjunctival hyperaemia with the use of latanoprost versus other prostaglandin analogues in patients with ocular hypertension ...
Rami Al-Rohil, Priyadharsini Nagarajan, Michael T. Tetzlaff, Applied Immunohistochemistry in the Evaluation of Skin Neoplasms, ... N Kenawy, S L Lake, S E Coupland, B E Damato, Conjunctival melanoma and melanocytic intra-epithelial neoplasia, Eye, 2013, 27, ... Distinction of conjunctival melanocytic nevi from melanomas by fluorescence in situ hybridization. Authors. *. Klaus J. Busam, ... None of the conjunctival melanocytic nevi showed a level of chromosomal aberrations that met FISH criteria for a diagnosis of ...
Mapping and clinical staging of conjunctival disease has improved. Adjunctive radiotherapy and topical chemotherapy have made ... Primary acquired melanosis is now differentiated histologically into hypermelanosis and conjunctival melanocytic intra- ... The rarity of conjunctival melanoma has impeded progress in the management of patients with this cancer; however, much progress ... 2 CoM is the second most frequent malignant neoplasm of the conjunctiva after squamous cell carcinoma.3 In addition to its ...
"Conjunctival Kaposis Sarcoma - The Eye Cancer Network". Archived from the original on 2010-11-24. Retrieved 2010-03-10. " ... Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). Eye cancers can be ... "Pigmented Conjunctival Tumors - The Eye Cancer Network". Archived from the original on 2009-08-20. Retrieved 2010-03-10. " ... "General Information: Malignant Conjunctival Tumors - The Eye Cancer Network". Archived from the original on 2010-11-24. ...
Conjunctival Neoplasms / surgery. Delivery of Health Care / statistics & numerical data. Eye Neoplasms / surgery*. Eyelid ... Orbital Neoplasms / surgery. Retrospective Studies. Waiting Lists*. From MEDLINE®/PubMed®, a database of the U.S. National ... or conjunctival tumours the interval of greatest delay was between referral and initial assessment, and for those with orbital ... Neoplasms / surgery. Female. Humans. Lacrimal Apparatus Diseases / surgery. Male. Middle Aged. Ontario. Ophthalmologic Surgical ...
Berman JJ (November 2004). "Tumor taxonomy for the developmental lineage classification of neoplasms". BMC Cancer. 4: 88. doi: ... Conjunctival squamous cell carcinoma (conjunctival SCC) and corneal intraepithelial neoplasia comprise what are called ocular ... Treatment of conjunctival SCC is usually surgical excision followed by cryotherapy. After this procedure, Conjunctival SCC can ... Mortality for conjunctival SCC ranges from 0-8%. Diagnosis is often made by biopsy, as well as CT (in the case of invasive SCC ...
Irrelevant of its cytology, a neoplasm of epithelial origin with this form of growth is also called papilloma. Papillomas can ... conjunctival papillomas are benign squamous epithelial tumors with minimal propensity toward malignancy. ... Most conjunctival tumors are isolated lesions. However, in a small percentage, conjunctival lesions may be an extension of ... The limbal conjunctival papilloma often is referred to as noninfectious conjunctival papilloma because it is believed that ...
Benign Neoplasm of Eye. *Benign Tumor. *Blepharitis. *Cataract. *Conjunctival Hemorrhage. *Dry Age-Related Macular Degeneration ...
Benign Neoplasm of Eye. *Blindness. *Cataract. *Central Serous Chorioretinopathy. *Conjunctival Hemorrhage. *Diabetic Eye ...
Diagnosis and Management of Conjunctival Melanoma (July/August 2010). Retinoblastoma, Part Two: Secondary Neoplasms in Older ... Diagnosis and Treatment of Conjunctival Lymphoma (September 2012). Fine-Needle Aspiration Biopsy for Ocular and Orbital Tumors ... Immunosuppressed and Distressed: A Conjunctival Conundrum (October 2009). The Case of the Ex-Marine With Exophthalmos ( ... Three Topical Treatments for Periocular and Conjunctival Malignancies (April 2011). ...
Conjunctival Diseases; Corneal Diseases; Endocrine Gland Neoplasms; Eye Neoplasms; Eyelid Diseases; Head and Neck Neoplasms; ... Neoplasms by Site; Neoplasms, Complex and Mixed; Neoplasms, Germ Cell and Embryonal; Orbital Diseases; Quality Control; Retinal ... Diseases; Retroperitoneal Neoplasms; Thoracic Neoplasms; Urogenital Neoplasms; Urologic Diseases; Uveal Diseases ... Lung Diseases; Male Urogenital Diseases; Neoplasms; Pancreas; Respiratory Tract Diseases Dr. Cai completed his residency in ...
Margin tumors should arouse the suspicion of a conjunctival neoplasm. The propensity of pigmented lesions to arise on the ... Focal melanoma of the upper lid in a patient with history of prior excised conjunctival melanoma. Courtesy of M Duffy, MD, PhD ... Focal melanoma of the upper lid in a patient with history of prior excised conjunctival melanoma. Courtesy of M Duffy, MD, PhD ...
... of patients with XP and ocular neoplasm occurs in 11% of them. Conjunctival ocular neoplasms are rare, only occurring in 2% of ... The second conjunctival biopsy also showed actinic keratosis. The third conjunctival biopsy showed features of CIN2, namely ... Figure 1: First conjunctival nodule at the right nasal limbus A) Right nasal limbus showing a vascularised conjunctival nodule ... Figure 3: Third conjunctival biopsy with Conjunctival Intraepithelial Neoplasia, grade 2 (CIN2). Squamous epithelium is ...
Malignant neoplasm of eye and adnexa, meninges and brain [head and neck cancer and brain tumors] [conjunctival neoplasms (e.g ... Malignant neoplasm of thyroid gland [head and neck cancer]. C75.0 - C75.4. Malignant neoplasm of other endocrine glands [head ... Malignant neoplasm of pancreas. C30.0 - C33. Malignant neoplasm of nasal cavity and middle ear, accessory sinuses, larynx and ... Malignant neoplasm of head, face and neck. C79.31, C79.49 - C79.52. Secondary malignant neoplasm of brain, other parts of ...
Categories: Conjunctival Neoplasms Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Histologic report of the biopsy was consistent with the diagnosis of KS with conjunctival edges free of neoplasm (Figure 2). ... A. Mortada, "Conjunctival regressing Kaposi sarcoma," British Journal of Ophthalmology, vol. 51, no. 4, pp. 275-280, 1967. View ... Isolated Bulbar Conjunctival Kaposis Sarcoma as a Primary Presentation of AIDS: A Case Report. Sofia Maia, Miguel Gomes, Luís ... Isolated bulbar conjunctival KP is an unusual site for its initial presentation and must be kept in mind in HIV positive ...
In contrast with this, Eng et al28 failed to detect HPV DNA in malignant epithelial neoplasms of the conjunctiva by PCR. They ... The study showed that conjunctival cancer was associated with HIV infection (10-fold increased risk of conjunctival cancer in ... In conclusion, conjunctival CIN is an important condition to know about because it is becoming more common, may be a marker for ... Cackett et al37 described a case of a 38 year old Zambian woman with a conjunctival lesion that predated her diagnosis of HIV ...
The microscopic features of the conjunctival epithelial cells were described by both direct analysis of the membrane-attached ... Application of impression cytology to the diagnosis of conjunctival neoplasms. Diagn. Cytopathol. 11, 246-249. doi: 10.1002/dc. ... 1997). Conjunctival impression cytology in the preterm infant and its relation to outcome. Eur. J Pediatr. 156:471. doi: ... 1989). Conjunctival impression cytology: feasibility of a field trial to detect subclinical vitamin a deficiency. Am. J. Clin. ...
A low grade neoplasm with a propensity for bone marrow involvement and relapse. Am J Clin Pathol 105:31-37. ... Histological presentation of conjunctival MALT lymphoma. (2A) Diffuse and homogeneous infiltration of the conjunctival ... We report a case of conjunctival MZL of the MALT type with an unusual clinical appearance, an CD5+ immunophenotype, and a ... In conclusion, the final diagnosis of a low malignant conjunctival MLZ of the MALT type was established and confirmed by the ...
Eyelid and Conjunctival Neoplasms Lilly Droll, Aaron Savar, Bita Esmaeli. Pages 535-550 ...
  • A conjunctival melanocytic nevus may on occasion be difficult to distinguish from melanoma both clinically and histopathologically. (wiley.com)
  • None of the conjunctival melanocytic nevi showed a level of chromosomal aberrations that met FISH criteria for a diagnosis of melanoma. (wiley.com)
  • All eight conjunctival melanomas (six unequivocal and two suspicious lesions) met FISH criteria for melanoma. (wiley.com)
  • Conjunctival melanoma (CoM) constitutes about 2% of all ocular malignancies and 5% of all ocular melanoma. (nature.com)
  • Clinical appearance of conjunctival melanosis: (a) freckle, (b) racial, (c) melanocytic intra-epithelial neoplasia (C-MIN) (d) invasive melanoma, and (e) pigmented squamous cell carcinoma. (nature.com)
  • Histology micrographs of conjunctival melanosis (haematoxylin and eosin): (a) freckle/racial, (b) C-MIN=1, (c) C-MIN ⩾ 5, (d) naevus, and (e) melanoma. (nature.com)
  • Focal melanoma of the upper lid in a patient with history of prior excised conjunctival melanoma. (medscape.com)
  • An example would be a well-circumscribed, bulbar conjunctival melanoma involving a limited area of the bulbar conjunctiva. (aao.org)
  • The most common primary intraocular neoplasm in cats is diffuse iridal melanoma, which presents as progressive hyperpigmentation of the iris with an expanding irregular surface. (merckvetmanual.com)
  • Conjunctival melanoma metastasis to contralateral orbit has never been reported. (ovid.com)
  • A histopathologic examination and immunohistochemistry confirmed metastases from conjunctival melanoma. (ovid.com)
  • Malignant conjunctival melanoma may metastasize to the contralateral orbit. (ovid.com)
  • Conjunctival Nevus, also known as nevus of conjunctiva , is related to malignant conjunctival melanoma and melanoma . (malacards.org)
  • Conjunctival adjunctive cryotherapy avoids exenteration in extensive lesions of pure PAM and in unifocal melanoma, but even after multiple therapies, multinodular malignant melanoma had a 45% rate of metastasis. (elsevier.com)
  • Included are substantial changes to the classification of conjunctival neoplasia and melanoma, based on the latest molecular studies. (blogspot.com)
  • Conjunctival Melanoma: Genetic and Epigenetic Insights of a Distinct Type of Melanoma. (cdc.gov)
  • Hot-spot mutations in the promoter region of telomerase reverse transcriptase (TERT promoter mutations) occur frequently in cutaneous and conjunctival melanoma and are exceedingly rare in uveal melanoma. (cdc.gov)
  • AB: Primary malignant melanoma of the conjunctiva is an uncommon neoplasm comprising only 2% of the malignant tumors of the eye. (kobe-u.ac.jp)
  • Recently we encountered a conjunctival malignant melanoma occurring in a man. (kobe-u.ac.jp)
  • The tumor was resected under local anesthesia and upon histological examination, the case was confirmed as a conjunctival malignant melanoma. (kobe-u.ac.jp)
  • This study aimed to investigate the microRNA (miRNA) profile in primary tumors from conjunctival melanoma with and without subsequent metastatic spread along with their coupled distant metastases to identify miRNAs likely to be involved in metastatic progression. (regionh.dk)
  • This observational study included 13 patients with metastatic conjunctival melanoma (follow-up: 1-39 years) treated at a Danish referral center. (regionh.dk)
  • Twenty-five patients with nonmetastatic conjunctival melanoma (follow-up: 5-17 years) were included for comparison. (regionh.dk)
  • Primary conjunctival melanoma with and without subsequent metastatic spread clustered separately according to miRNA expression, and 15 miRNAs were found to have significant differential expression. (regionh.dk)
  • A comparison of primary conjunctival melanoma with their pair-matched metastases identified six significant differentially expressed miRNAs (hsa-miR-1246 and hsa-miR-302d-5p, hsa-mir-6084, hsa-miR-184, hsa-mir-658, and hsa-mir-4427). (regionh.dk)
  • Primary conjunctival melanoma with and without subsequent metastatic spread separated clearly on the miRNA level when profiled with microarray-based methods. (regionh.dk)
  • Predović J, Kuzmanović-Elabjer B, Petrinović-Dorešić J. Conjunctival Melanoma - A Case Report. (srce.hr)
  • Conjunctival melanoma is a relatively rare malignancy. (srce.hr)
  • Histopathology of the tumor indicated conjunctival melanoma. (srce.hr)
  • These have been particularly substantial change to the classification of conjunctival neoplasia and melanoma, based on the latest information from genetic and molecular studies. (renoufbooks.com)
  • Conjunctival melanoma: a review of conceptual and treatment advances. (edu.au)
  • Expression of cancer-testis antigens (MAGE-A1, MAGE-A3/6, MAGE-A4, MAGE-C1 and NY-ESO-1) in primary human uveal and conjunctival melanoma. (edu.au)
  • Conservative resection and adjuvant plaque brachytherapy for early stage conjunctival melanoma. (edu.au)
  • In vitro effects of histone deacetylase inhibitors and mitomycin C on tenon capsule fibroblasts and conjunctival melanoma cells. (edu.au)
  • Population-based assessment of clinical characteristics predicting outcome of conjunctival melanoma in whites. (arctichealth.org)
  • To identify the clinical determinants of prognosis and the incidence of malignant conjunctival melanoma in whites. (arctichealth.org)
  • A nationwide search identified 85 patients in whom primary conjunctival melanoma was diagnosed in Finland between 1967 and 2000, all of whom were enrolled. (arctichealth.org)
  • The annual crude incidence of conjunctival melanoma in Finland was 0.51 per million inhabitants, and the age-adjusted incidence (mean, 0.54) increased from 0.4 to 0.8 during the 34-year study period. (arctichealth.org)
  • The incidence of conjunctival melanoma in the white population of Finland increased analogous to cutaneous melanoma. (arctichealth.org)
  • We have extended the concept of autologous conjunctival transplantation for corneal resurfacing as recommended by Thoft to reconstruction in 14 patients with unilateral abnormalities of the bulbar and palpebral conjunctiva caused by alkali burns (2), irradiation (2), neoplasms (3), degenerative diseases (5), trauma (1), and developmental anomalies (1). (nih.gov)
  • Squamous conjunctival carcinoma typically occurs on the bulbar conjunctiva, originating at the limbus, and often spreads onto the cornea. (omicsonline.org)
  • On slit lamp biomicroscopy, a pinkish white, elevated, mass of 25 mm diameter was seen at nasal aspect of bulbar conjunctiva of right eye conjunctival congestion was noted adjacent to the lesion. (omicsonline.org)
  • 1 , 2 CoM is the second most frequent malignant neoplasm of the conjunctiva after squamous cell carcinoma. (nature.com)
  • Conjunctival diagram for tumour mapping displaying the conjunctiva as a flat surface. (nature.com)
  • KS is a malignant neoplasm of the vascular endothelium that can affect the eyelids, the lacrimal sac or gland, the orbit, and bulbar or palpebral conjunctiva. (hindawi.com)
  • Conjunctival intraepithelial neoplasia (CIN), in keeping with the general classification of other intraepithelial tumours elsewhere in the body, is dysplasia of the ocular surface epithelium that has not yet invaded the substantia propria of the conjunctiva or Bowman layer of the cornea. (bmj.com)
  • A progression of the disease to involve the conjunctiva was then suspected and a conjunctival biopsy was performed. (hindawi.com)
  • Malignant neoplasms arising in the eyelid and conjunctiva tend to spread to ________ and ______ Lymph nodes. (brainscape.com)
  • [2] Conjunctival lesions present as a localized yellow nodule on the bulbar conjunctiva (Figure 3). (aao.org)
  • Physical examination of the left eye revealed two pink conjunctival mass, measuring 30×15 mm, involving the palpebral conjunctiva and superior and inferior cul-de-sac. (ispub.com)
  • 12 A sensory organ benign neoplasm that is located in the eye conjunctiva. (malacards.org)
  • Keywords OSSN HPV Conjunctiva Neoplasia Case description A healthy immunocompetent 55-year-old lady came to our attention for prosecution of care of a right recurrent conjunctival squamous cell carcinoma. (deepdyve.com)
  • HPV infection with the most common neoplasms of the conjunctiva [1]. (deepdyve.com)
  • Squamous cell carcinoma (SCC) is the most common neoplasm of the conjunctiva [ 1 ]. (biomedcentral.com)
  • Sections are included on all recognized neoplasms (and their variants) of the eye, lacrimal apparatus, and conjunctiva. (renoufbooks.com)
  • In this volume, the examination techniques, classification, and differential diagnosis of eyelid tumors and conjunctival and corneal tumors are carefully explained, and treatment options are considered in detail. (matthewsbooks.com)
  • Specifically, conjunctival papillomas are benign squamous epithelial tumors with minimal propensity toward malignancy. (aao.org)
  • Eyelid and conjunctival tumors are the most frequent primary ophthalmic neoplasms. (merckvetmanual.com)
  • Carol L Shields MD Written by world-renowned authorities in ocular oncology at the Wills Eye Institute, this text/atlas is a complete pictorial and textual guide to the clinical features, pathology, diagnosis, and management of eyelid, conjunctival, and orbital tumors and pseudotumors. (egeneralmedical.com)
  • This thoroughly updated edition combines the content of Atlas of Eyelid and Conjunctival Tumors and Atlas of Orbital Tumors and contains over 50 percent new material.Each entity is presented in an easy-to-follow format: a concise description with references on the left-hand page and six illustrations on the right-hand page. (egeneralmedical.com)
  • This unsurpassed ocular oncology resource is a comprehensive guide to the clinical features, diagnosis, management, and pathology of eyelid, conjunctival, and orbital tumors and pseudotumors, depicting clinical variations, treatment and histopathologic characteristics of the wide spectrum of neoplasms and related lesions. (ovid.com)
  • We used a tissue conservation method, an adaptation of the Mohs' micrographic technique for cutaneous tumors, to monitor the conjunctival tissue margins by histologic review at initial tumor excision. (elsevier.com)
  • Conjunctival tissue tumors have a varied presentation, and few series studies on pediatric patients have been published. (bvsalud.org)
  • The objective of this paper is to report the histopathologic diagnoses (spanning over 1988-2013) of conjunctival tumors in children younger than 14 years. (bvsalud.org)
  • These findings are consistent with those reported in other studies regarding the frequencies of the histopathology of conjunctival tumors in the pediatric population . (bvsalud.org)
  • The purpose of this study is to evaluate the therapeutic efficacy of interferon alfa 2b and topical mitomycin C in patients with diagnosis of conjunctival-corneal intraepithelial neoplasia. (clinicaltrials.gov)
  • The corneal and conjunctival intraepithelial neoplasia is the most common malignant tumor of the ocular surface. (clinicaltrials.gov)
  • To evaluate the efficacy of topical mitomycin C as a treatment of corneal conjunctival intraepithelial neoplasia. (nih.gov)
  • An open prospective analysis of 20 cases of corneal conjunctival intraepithelial neoplasia with recurrent disease (17 patients) or refusing surgery (three patients) were treated with topical mitomycin C. Treatment was with mitomycin C eye drops, either 0.02% or 0.04%, four times daily for 1 week followed by a week off the cycle then repeated for a second week. (nih.gov)
  • Mitomycin C is effective in inducing regression of corneal conjunctival intraepithelial neoplasia. (nih.gov)
  • Even before the term ocular surface squamous neoplasia (OSSN) was introduced to encompass the spectrum of conjunctival and corneal intraepithelial neoplasia (CIN) and SCC [ 1 - 4 ], published series often included both intraepithelial and invasive squamous neoplasia. (omicsonline.org)
  • Primary acquired melanosis is now differentiated histologically into hypermelanosis and conjunctival melanocytic intra-epithelial neoplasia, for which an objective reproducible scoring system has been developed. (nature.com)
  • 5 We have also devised a system for histological scoring for conjunctival melanocytic intra-epithelial neoplasia (C-MIN), which in our institution has replaced the term primary acquired melanosis (PAM) with varying (subjectively evaluated) degrees of atypia. (nature.com)
  • Histologically, conjunctival melanosis is divided into two groups according to the pathological processes involved: 'hypermelanosis' and 'melanocytic neoplasia' ( Table 2 and Figure 3 ). (nature.com)
  • Conjunctival squamous cell carcinoma (conjunctival SCC) and corneal intraepithelial neoplasia comprise what are called ocular surface squamous cell neoplasias. (wikipedia.org)
  • It is possible that the early acquired melanosis is overshadowed by more visible conjunctival intraepithelial neoplasia (CIN) lesions. (omicsonline.org)
  • To summarise the main causes and associations of conjunctival intraepithelial neoplasia (CIN) found in the literature to date. (bmj.com)
  • Napora et al 7 have included invasive SCC in their definition of conjunctival intraepithelial neoplasia. (bmj.com)
  • Upon examination, she was found disease- Introduction free in the right eye but displayed a left conjunctival intraepithelial neoplasia (CIN grade I) and low-grade Ocular surface squamous neoplasia (OSSN) is among cervical squamous dysplasia. (deepdyve.com)
  • Oncocytoma associated with an ocular surface squamous neoplasm, namely conjunctival intraepithelial neoplasia, is very hard to find in the literature. (usp.br)
  • The conjunctival tissue revealed conjunctival intraepithelial neoplasia 3 (severe dysplasia). (usp.br)
  • This case documents a rare synchronous dual ocular neoplasia, a very unlikely coexistence of oncocytoma with conjunctival intraepithelial neoplasia. (usp.br)
  • Lymphoma and lymphosarcoma are used interchangeably to describe neoplasia arising from the lymphoid system (lymph nodes, thymus, spleen, mucosal-conjunctival and skin-associated lymphoid tissue). (vetstream.com)
  • Pyogenic granuloma developing rapidly after excision of corneal/conjunctival intraepithelial neoplasia]. (elsevier.com)
  • For example, the terminology of conjunctival melanocytic lesions is confusing. (nature.com)
  • Although rare, inverted conjunctival papillomas sometimes are referred to as mucoepidermoid papillomas because these lesions possess both a mucous component and an epidermoid component. (aao.org)
  • A 9 year old Indian boy with a history of XP presented with conjunctival lesions over the course of one year. (omicsonline.org)
  • We present a case of an isolated bulbar conjunctival KS on a 43-year-old HIV positive male, with no other lesions. (hindawi.com)
  • Ophthalmic presentation often occurs in the context of systemic KS, and isolated conjunctival lesions are rare [ 5 - 7 ]. (hindawi.com)
  • T-cell lymphoma should be considered in patients with a history of MF presenting with conjunctival and skin lesions. (hindawi.com)
  • It features 2,532 photographs and surgical drawings-2,137 in full color-that depict the clinical variations, histopathologic characteristics, and treatment of all neoplasms and related lesions. (egeneralmedical.com)
  • The tumor cells infiltrated the conjunctival epithelium with the formation of lymphoepithelial lesions. (ispub.com)
  • We tested a cohort of uveal and conjunctival melanomas as well as conjunctival benign and premalignant melanocytic lesions for TERT promoter mutations in order to elucidate the role of these mutations in tumor progression. (cdc.gov)
  • Conjunctival nevi are benign lesions with wide variation in clinical and histopathological features. (bvsalud.org)
  • We hereby report a rare case of conjunctival involvement of T-cell lymphoma in a patient with MF. (hindawi.com)
  • We report a 35-year-old woman with multicentric CD5-positive mucosa associated lymphoid tissue (MALT) lymphoma of conjunctival region. (ispub.com)
  • The occurrence of multicentric conjunctival CD5-positive MALT lymphoma in the younger age further support to the notation that CD5+ MALT-lymphomas arising in the ocular adnexa might be characterized by an unusual clinical course. (ispub.com)
  • In recent studies, several cases of conjunctival CD5-positive MALT lymphoma have been reported [ 3 5 6 ]. (ispub.com)
  • Other conjunctival neoplasms such as lymphoma may be associated with a sub conjunctival hemorrhage. (pregnancycrawler.com)
  • [ 18 ] In these rare cases, the sebaceous gland carcinoma may fill the conjunctival epithelium and create the appearance of squamous cell carcinoma in situ. (medscape.com)
  • While establishing this diagnosis was not particularly challenging in this well-oriented and completely resected tumor, it is possible that a smaller sampling of the tumor, such as a core biopsy, could have been misinterpreted as a basaloid-appearing primary breast neoplasm with a differential diagnosis potentially including basaloid forms of ductal carcinoma in situ, basaloid forms of solid/nested invasive ductal carcinoma, and adenoid cystic carcinoma. (thefreedictionary.com)
  • Irrelevant of its cytology, a neoplasm of epithelial origin with this form of growth is also called papilloma. (aao.org)
  • The ocular involvement manifested as conjunctival actinic keratosis/epithelial dysplasia and atypical secondary acquired melanosis. (omicsonline.org)
  • The microscopic features of the conjunctival epithelial cells were described by both direct analysis of the membrane-attached cells and analysis of cytospinned captured cells using several staining procedures. (frontiersin.org)
  • Egbert et al reported a case of conjunctival papilloma in an infant born to a mother with HPV infection of the vulva during pregnancy. (aao.org)
  • We report a rare case of conjunctival dysplasia and atypical secondary acquired melanosis in a patient with XP. (omicsonline.org)
  • We report a case of conjunctival MZL of the MALT type with an unusual clinical appearance, an CD5+ immunophenotype, and a history of idiopathic non-specific anterior uveitis. (bmj.com)
  • Herein, we report a rare case of conjunctival involvement of MF. (hindawi.com)
  • In this study, we described a case of conjunctival MZL of the MALT type with an unusual clinical course, a CD5+ immunophenotype and favorable response to chemotherapy. (ispub.com)
  • Uveitis was found in 8 patients (4.3%), and ocular surface neoplasms were found in 2 patients (1.1%), including 1 case of conjunctival Kaposi sarcoma and 1 case of conjunctival squamous cell carcinoma. (arvojournals.org)
  • We evaluated a fluorescence in situ hybridization (FISH) assay, which has previously been shown to be of value for the diagnosis of melanocytic nevi and melanomas of the skin, using probes targeting 6p25 (RREB1), 6q23 (MYB), 11q13 (CCND1) and centromere 6 (CEP6), for its potential to assist in the distinction of conjunctival melanocytic nevi from melanomas. (wiley.com)
  • TERT promoter mutation analysis on fresh tumor DNA and DNA from formalin-fixed, paraffin-embedded specimens was performed by SNaPshot analysis in 102 uveal melanomas, 39 conjunctival melanomas, 26 PAM with atypia, 14 PAM without atypia, and 56 conjunctival nevi. (cdc.gov)
  • The aim of our study was to identify the distribution of the histopathologic types of conjunctival nevi among the Saudi population and to provide the basic knowledge needed for proper clinical diagnosis . (bvsalud.org)
  • This retrospective study of surgically excised benign conjunctival nevi was conducted at a tertiary care eye hospital from 1995 to 2006. (bvsalud.org)
  • A total 105 conjunctival nevi were included from 104 consecutive patients [mean age, 26 years, 54 males and 50 females ]. (bvsalud.org)
  • Immunohistochemical studies of atypical conjunctival melanocytic nevi. (harvard.edu)
  • and to the development of intralymphatic spread ("in-transit" local metastasis) within the conjunctival sac in six patients. (elsevier.com)
  • Large, free conjunctival grafts from bulbar and forniceal donor sites were used. (nih.gov)
  • Isolated bulbar conjunctival KP is an unusual site for its initial presentation and must be kept in mind in HIV positive patients. (hindawi.com)
  • An acquired bulbar conjunctival mass was excised and diagnosed histologically as a benign fibroma, a rare neoplasm. (lww.com)
  • One patient with a thick nodule at presentation required a parotidectomy and radical neck dissection for cervical metastases after recurrence in the conjunctival sac. (elsevier.com)
  • Eye neoplasms can affect all parts of the eye , and can be a benign tumor or a malignant tumor ( cancer ). (wikipedia.org)
  • For most eyelid and conjunctival neoplasms, the gold standard treatment remains complete surgical resection, using either frozen-section control of tumor margins or Mohs micrographic surgery-a precise, systematic excision of skin cancers that minimizes damage to surrounding healthy tissue. (aao.org)
  • Conventional histological examination was performed on an incisional biopsy of the conjunctival tumor. (ispub.com)
  • Staging investigations, which included full blood count, chest-ray, computer tomography scans, and magnetic resonance imaging of the thorax, abdomen, and of the head and neck, as well as bone marrow aspiration biopsy, confirmed the localized conjunctival tumor. (ispub.com)
  • Although surgical excision, with or without adjunctive cryotherapy, is an accepted method of managing conjunctival squamous cell carcinoma, histologically verified tumor-free surgical margins cannot be assured by excision alone. (elsevier.com)
  • In all patients, the tumor-free conjunctival defect was allowed to heal by secondary intention. (elsevier.com)
  • We conducted a retrospective, descriptive, and observational study by reviewing the database of all children in whom a conjunctival tumor was surgically removed at Hospital de Ojos y Oídos "Dr. Rodolfo Robles V.," Benemérito Comité Pro Ciegos y Sordos de Guatemala . (bvsalud.org)
  • Moreover, the HPV genome is identifiable in most conjunctival papillomas and in 85% of conjunctival dysplasias and carcinomas. (aao.org)
  • Most conjunctival squamous cell carcinomas are removed with surgery. (wikipedia.org)
  • In the present study, DNA extracted and purified from 36 Conjunctival Squamous Cell Carcinomas (CSCC) was evaluated by PCR for HPV DNA sequences. (biomedcentral.com)
  • All articles reporting data of HPV prevalence in conjunctival carcinomas were selected and reviewed (45 reports). (biomedcentral.com)
  • A 60-year-old man who underwent a left primary conjunctival neoplasm resection 11 months ago presented for the evaluation of a conjunctival dark-colored mass with a bulging left lower eyelid that directly invaded the orbits bilaterally. (ovid.com)
  • Easily mistaken for a benign pinguecula or pterygium, conjunctival intraepithelial neoplasm is far more ominous. (reviewofoptometry.com)
  • Pre-Malignant Neoplasm is related to conjunctival intraepithelial neoplasm and bartholin's gland adenoid cystic carcinoma . (malacards.org)
  • Histologic report of the biopsy was consistent with the diagnosis of KS with conjunctival edges free of neoplasm (Figure 2 ). (hindawi.com)
  • A diagnosis of conjunctival involvement by MF was made. (hindawi.com)
  • Treatment of conjunctival SCC is usually surgical excision followed by cryotherapy. (wikipedia.org)
  • An excisional biopsy and cryotherapy on the conjunctival edges were done on January 2011. (hindawi.com)
  • The clinical and histopathologic findings of bilateral conjunctival preneoplasia and atypical secondary acquired melanosis in a patient with XP are presented in this report. (omicsonline.org)
  • Recurrent conjunctival papillomas may extend into the nasolacrimal duct causing obstruction. (aao.org)
  • Alfonso Iovieno Simonetta Piana Laura Chiesi Cristina Fodero Luigi Fontana Received: 11 December 2016 / Accepted: 20 May 2017 / Published online: 6 June 2017 Springer Science+Business Media Dordrecht 2017 Abstract repeated exposure to HPV could explain coexistence Purpose To describe a case of bilateral conjunctival of different genotypes. (deepdyve.com)
  • Here, we report two cases of conjunctival SCC, both in elderly males who presented with whitish painless mass encroaching the cornea. (omicsonline.org)
  • Literature reviewed yielded no published study outlining the prevalence of conjunctival papillomas in a cross section of a population. (aao.org)
  • Lim EWL, Lim L, Jajeh IA , Jayasinghe LS (2016) Conjunctival Dysplasia and Atypical Secondary Acquired Melanosis in Xeroderma Pigmentosum. (omicsonline.org)
  • We present our clinical and histopathological findings of conjunctival dysplasia and atypical secondary acquired melanosis in this patient. (omicsonline.org)
  • Although acquired melanosis with atypia is known to occur and is often reported as a cutaneous manifestation of XP, it is rarely reported as a conjunctival manifestation in XP. (omicsonline.org)
  • No information is available on the presence of these mutations in the conjunctival melanocytic precursor lesion primary acquired melanosis (PAM). (cdc.gov)
  • Feline leukemia virus (FeLV) infection causes immunosuppression, degeneration of the hematopoietic system, and fatal neoplasms. (asm.org)
  • Oncocytoma of the eyelid is a rare neoplasm. (usp.br)
  • citation needed] Squamous cell carcinoma of eye tissues is one of the most frequent neoplasms of cattle. (wikipedia.org)
  • [ 25 ] Controversy exists regarding the prophylactic removal of a nevus sebaceous, but when malignant neoplasms are suspected, removal is warranted regardless. (medscape.com)
  • The techniques and results of our experience with free conjunctival grafts in 14 patients are discussed. (nih.gov)
  • Spontaneous sub-conjunctival haemorrhage in patients using long-term topical corticosteroids. (college-optometrists.org)
  • 3 ] ocular abnormalities occur in 40% of patients with XP and ocular neoplasm occurs in 11% of them. (omicsonline.org)
  • Conjunctival ocular neoplasms are rare, only occurring in 2% of patients with XP [ 3 ]. (omicsonline.org)
  • For patients with lid, brow, or conjunctival tumours the interval of greatest delay was between referral and initial assessment, and for those with orbital, lacrimal, or intraocular tumours it was between initial assessment and consent. (biomedsearch.com)
  • Conjunctival pallor is evident in patients with severe anemia. (medscape.com)
  • Qiu W, Lei M, Li J, Wang N, Lian X. Activated Hair Follicle Stem Cells and Wnt/β-catenin Signaling Involve in Pathnogenesis of Sebaceous Neoplasms. (medsci.org)
  • Abnormalities of sebaceous gland progenitor cells contribute to the development of sebaceous neoplasms, but little is known about the role of HFSCs during sebaceous neoplasm development. (medsci.org)
  • Here, using dimethylbenzanthracene (DMBA) plus 12-o-tetradecanoyl phorbol-13-acetate (TPA) treatment developing sebaceous neoplasms (SNs) were identified with H&E and Oil red O staining. (medsci.org)
  • We found hair follicle and epidermal cell markers were expressed in sebaceous neoplasms. (medsci.org)
  • Furthermore, SOX-9 and CD34-positive HFSCs were located in the basal layer of sebaceous lobules within the sebaceous neoplasms. (medsci.org)
  • Finally, Wnt10b/β-catenin signaling was activated within the basal cells of sebaceous lobules in the sebaceous neoplasms. (medsci.org)
  • Collectively, our findings suggest that the abnormal activation of both HFSCs and Wnt10b/β-catenin signaling involves in the development of sebaceous neoplasms. (medsci.org)
  • However, it remains unknown whether the renewal of sebaceous neoplasms (SNs) induced by TPA is dependent on HFSCs. (medsci.org)
  • A strong association exists between human papillomavirus (HPV) types 6 and 11 and the development of conjunctival papillomas. (aao.org)
  • An important gene associated with Conjunctival Nevus is MLANA (Melan-A), and among its related pathways/superpathways are Development Angiotensin activation of ERK and Development Endothelin-1/EDNRA signaling . (malacards.org)
  • According to the Revised European American classification of lymphoid neoplasms (REAL classification) 2 the most common ocular NHL, arising from mucosa associated lymphoid tissue (MALT) and the marginal zone of lymph follicles, is included in the group of extranodal peripheral B cell lymphomas. (bmj.com)
  • Primary hepatobiliary neoplasms (PHN) are uncommon in cats, and originate in hepatocytes, intra- and extrahepatic bile ducts, mesenchymal cells, and cells of neuroendocrine origin. (scielo.br)
  • To determine the occurrence of BRAF V600E gene mutations and copy number changes of all autosome arms and genes known to be frequently altered in tumorigenesis in primary and metastatic conjunctival melanomas (CoMs). (cdc.gov)
  • Paraneoplastic pemphigus is associated with neoplasms, most commonly of lymphoid tissue, but also Waldenström's macroglobulinemia, sarcomas, thymomas and Castleman's disease. (aafp.org)