Congenital hypothyroidism. Medical search

A condition in infancy or early childhood due to an in-utero deficiency of THYROID HORMONES that can be caused by genetic or environmental factors, such as thyroid dysgenesis or HYPOTHYROIDISM in infants of mothers treated with THIOURACIL during pregnancy. Endemic cretinism is the result of iodine deficiency. Clinical symptoms include severe MENTAL RETARDATION, impaired skeletal development, short stature, and MYXEDEMA.

A syndrome that results from abnormally low secretion of THYROID HORMONES from the THYROID GLAND, leading to a decrease in BASAL METABOLIC RATE. In its most severe form, there is accumulation of MUCOPOLYSACCHARIDES in the SKIN and EDEMA, known as MYXEDEMA.

Defective development of the THYROID GLAND. This concept includes thyroid agenesis (aplasia), hypoplasia, or an ectopic gland. Clinical signs usually are those of CONGENITAL HYPOTHYROIDISM.

The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.

The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.

A glycoprotein hormone secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Thyrotropin stimulates THYROID GLAND by increasing the iodide transport, synthesis and release of thyroid hormones (THYROXINE and TRIIODOTHYRONINE). Thyrotropin consists of two noncovalently linked subunits, alpha and beta. Within a species, the alpha subunit is common in the pituitary glycoprotein hormones (TSH; LUTEINIZING HORMONE and FSH), but the beta subunit is unique and confers its biological specificity.

Blood tests used to evaluate the functioning of the thyroid gland.

A highly vascularized endocrine gland consisting of two lobes joined by a thin band of tissue with one lobe on each side of the TRACHEA. It secretes THYROID HORMONES from the follicular cells and CALCITONIN from the parafollicular cells thereby regulating METABOLISM and CALCIUM level in blood, respectively.

Natural hormones secreted by the THYROID GLAND, such as THYROXINE, and their synthetic analogs.

An infant during the first month after birth.

Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency (HYPOTHYROIDISM), or hormone overproduction (HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic (GOITER, ENDEMIC).

A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3.

A dehydrated extract of thyroid glands from domesticated animals. After the removal of fat and connective tissue, the extract is dried or lyophilized to yield a yellowish to buff-colored amorphous powder containing 0.17-0.23% of iodine.

A hemeprotein that catalyzes the oxidation of the iodide radical to iodine with the subsequent iodination of many organic compounds, particularly proteins. EC 1.11.1.8.

A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.

Organizations which assume the financial responsibility for the risks of policyholders.

A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, cardiovascular and cerebral circulation, brain, thyroid, and joints.

A beverage prepared from SOYBEANS.

Cell surface proteins that bind pituitary THYROTROPIN (also named thyroid stimulating hormone or TSH) and trigger intracellular changes of the target cells. TSH receptors are present in the nervous system and on target cells in the thyroid gland. Autoantibodies to TSH receptors are implicated in thyroid diseases such as GRAVES DISEASE and Hashimoto disease (THYROIDITIS, AUTOIMMUNE).

Any of six membrane-covered openings between the CRANIAL SUTURES in the incompletely ossified skull of the fetus or newborn infant. The fontanelles normally close sometime after birth.

A group of autosomal recessive disorders marked by a deficiency of the hepatic enzyme PHENYLALANINE HYDROXYLASE or less frequently by reduced activity of DIHYDROPTERIDINE REDUCTASE (i.e., atypical phenylketonuria). Classical phenylketonuria is caused by a severe deficiency of phenylalanine hydroxylase and presents in infancy with developmental delay; SEIZURES; skin HYPOPIGMENTATION; ECZEMA; and demyelination in the central nervous system. (From Adams et al., Principles of Neurology, 6th ed, p952).

Blood proteins that bind to THYROID HORMONES such as THYROXINE and transport them throughout the circulatory system.

A thioureylene antithyroid agent that inhibits the formation of thyroid hormones by interfering with the incorporation of iodine into tyrosyl residues of thyroglobulin. This is done by interfering with the oxidation of iodide ion and iodotyrosyl groups through inhibition of the peroxidase enzyme.

Inorganic binary compounds of iodine or the I- ion.

Predeciduous teeth present at birth. They may be well formed and normal or may represent hornified epithelial structures without roots. They are found on the gingivae over the crest of the ridge and arise from accessory buds of the dental lamina ahead of the deciduous buds or from buds of the accessory dental lamina. (From Jablonski, Dictionary of Dentistry, 1992)

The presence of an excessively large tongue, which may be congenital or may develop as a result of a tumor or edema due to obstruction of lymphatic vessels, or it may occur in association with hyperpituitarism or acromegaly. It also may be associated with malocclusion because of pressure of the tongue on the teeth. (From Jablonski, Dictionary of Dentistry, 1992)

The use of fluorescence spectrometry to obtain quantitative results for the FLUORESCENT ANTIBODY TECHNIQUE. One advantage over the other methods (e.g., radioimmunoassay) is its extreme sensitivity, with a detection limit on the order of tenths of microgram/liter.

Hypersecretion of THYROID HORMONES from the THYROID GLAND. Elevated levels of thyroid hormones increase BASAL METABOLIC RATE.

The ability to learn and to deal with new situations and to deal effectively with tasks involving abstractions.

A mass of histologically normal tissue present in an abnormal location.

Pertechnetate scintigraphy in primary congenital hypothyroidism. (1/303)

Primary congenital hypothyroidism (PCH) is currently detected effectively by heel-stick screening. When elevated thyrotropin (TSH) and/or decreased T4 are found in the blood of neonates, they are recalled, values are confirmed in venous blood and thyroxine replacement therapy (TRT) is immediately instituted, thus cretinism or severe retardation is prevented. However, in a significant percentage of neonates with abnormal blood levels of T4 or TSH, the disorder is transient. To help determine the exact cause of PCH and the possibility of transient PCH, pinhole thyroid imaging is performed 30 min after an intravenous injection of 18.5 MBq (500 microCi) 99mTc-pertechnetate (TcPT). Patients with a nonvisualized gland or patients with images suggesting dyshormonogenesis are reevaluated at age 3-4 y to exclude transient PCH. METHODS: To define the role of TcPT imaging in determining the exact etiology of PCH and the possibility of its being transient, we reviewed data from 103 neonates with PCH who had scintigraphy in our laboratory between 1970 and 1996 and we correlated the results with clinical outcome. RESULTS: Four patterns of thyroid scintigrams were recognized and these determined patient classification: (a) normal in 7 patients with false-positive heel-stick screening but normal venous blood hormone levels; (b) hypoplasia-ectopia in 32 patients requiring lifelong TRT; (c) nonvisualization in 35 patients-32 with agenesis requiring lifelong TRT and 3 with fetal thyroid suppression by maternal antibodies whose TRT was discontinued at a later age; and (d) dyshormonogenesis (markedly increased TcPT concentration) in 29 patients-25 with permanent PCH requiring lifelong TRT and 4 with transient PCH in whom TRT was discontinued. Of the 25 patients with dyshormonogenesis, 12 belonged to five families with two or three siblings having the same disorder. CONCLUSION: TcPT thyroid scintigraphy in the neonate with PCH provides a more specific diagnosis, is useful for selecting patients for re-evaluation to uncover transient PCH and discontinue TRT and defines dyshormonogenesis, which is familial and requires genetic counseling. It is also cost-effective. (+info)

Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism. (2/303)

Pax proteins are transcriptional regulators that play important roles during embryogenesis. These proteins recognize specific DNA sequences via a conserved element: the paired domain (Prd domain). The low level of organized secondary structure, in the free state, is a general feature of Prd domains; however, these proteins undergo a dramatic gain in alpha-helical content upon interaction with DNA ('induced fit'). Pax8 is expressed in the developing thyroid, kidney and several areas of the central nervous system. In humans, mutations of the Pax8 gene, which are mapped to the coding region of the Prd domain, give rise to congenital hypothyroidism. Here, we have investigated the molecular defects caused by a mutation in which leucine at position 62 is substituted for an arginine. Leu62 is conserved among Prd domains, and contributes towards the packing together of helices 1 and 3. The binding affinity of the Leu62Arg mutant for a specific DNA sequence (the C sequence of thyroglobulin promoter) is decreased 60-fold with respect to the wild-type Pax8 Prd domain. However, the affinities with which the wild-type and the mutant proteins bind to a non-specific DNA sequence are very similar. CD spectra demonstrate that, in the absence of DNA, both wild-type Pax8 and the Leu62Arg mutant possess a low alpha-helical content; however, in the Leu62Arg mutant, the gain in alpha-helical content upon interaction with DNA is greatly reduced with respect to the wild-type protein. Thus the molecular defect of the Leu62Arg mutant causes a reduced capability for induced fit upon DNA interaction. (+info)

Early cellular abnormalities induced by RET/PTC1 oncogene in thyroid-targeted transgenic mice. (3/303)

The RET/PTC1 oncogene, a rearranged form of the RET proto-oncogene, has been reported to be associated with human papillary thyroid carcinomas. We have shown that targeted expression of RET/PTC1 in the thyroid gland leads to the development of thyroid carcinomas in transgenic mice with histologic and cytologic similarities to human papillary thyroid carcinoma. To further investigate how RET/PTC1 expression contributes to the pathogenesis of papillary thyroid tumor, the time of tumor onset and the early phenotypic consequences of RET/PTC1 expression in thyrocytes were determined. All high copy transgenic mice developed bilateral thyroid tumors as early as 4 days of age. At embryological days 16-18, increased proliferation rate, distorted thyroid follicle formation and reduced radioiodide concentrating activity were identified in transgenic embryos. The reduced radioiodide concentrating activity was attributed to decreased expression of the sodium-iodide symporter. Our study showed that RET/PTC1 not only increased proliferation of thyrocytes, it also altered morphogenesis and differentiation. These findings provide a model for the role of RET/PTC1 in the formation of abnormal follicles with reduced iodide uptake ability observed in human papillary thyroid carcinoma. (+info)

Intellectual outcome at 12 years of age in congenital hypothyroidism. (4/303)

BACKGROUND: The intellectual outcome in children with congenital hypothyroidism detected by neonatal screening is generally good; however, subtle neurological dysfunctions, subnormal IQ, or both, have been reported. OBJECTIVE: To evaluate the intellectual outcome in 12-year-old patients with congenital hypothyroidism, detected by neonatal screening, in an attempt to identify factors that may affect intellectual development. METHODS: The intelligence quotient (IQ) of 40 children with congenital hypothyroidism was evaluated at 12 years of age, using the Wechsler Intelligence Scale for Children -- Revised, and compared with the IQ of 40 healthy siblings (control group). RESULTS: The mean IQ score (88.4+/-13.1) was not significantly different from that of the control group (93.4+/-10.7). Thirteen patients showed subnormal IQ score (72.4+/-4.9) compared with their siblings (86.7+/-9.6; P<0.0001) and with the other patients (96.1+/-9.6; P<0.0001). The low IQ score was associated with lower serum concentrations of thyroxine at diagnosis, poor treatment compliance during follow-up and lower familial IQ. Interviews with parents of children with congenital hypothyroidism revealed that a refusal to acknowledge the disease was linked to poor attention to the child's emotional life and to poor treatment compliance in some cases (11%). CONCLUSION: Even though the mean IQ score in patients with congenital hypothyroidism falls within normal for the control population, low IQ scores may be present in patients with severe hypothyroidism, inadequate compliance to replacement therapy during follow-up and poor parental pedagogic attitude. (+info)

Iodine and neuropsychological development. (5/303)

The establishment of the essential link among iodine deficiency, thyroid function and brain development has emerged from a fascinating combination of clinical, epidemiologic and experimental studies. The central human phenomenon that focuses this relationship is the condition of endemic cretinism, described from the Middle Ages and characterized in its fully developed form by severe brain damage, deaf mutism and a spastic state of the hands and feet. The demonstration of the prevention of cretinism in a double-blind controlled trial with injections of iodized oil in Papua New Guinea (1966-1970) established the causal role of iodine deficiency in cretinism by an effect on the developing fetal brain. Cretinism could not be prevented unless the iodized oil was given before pregnancy. Iodine deficiency is now regarded by the WHO as the most common preventable cause of brain damage in the world today, with at least 30 million suffering from this preventable condition. Since 1986 the international NGO, the International Council for Control of Iodine Deficiency Disorders, has worked closely as an expert group with WHO and UNICEF in assisting countries with a program of universal salt iodization for the elimination of iodine deficiency as a cause of brain damage by the year 2000. In 1996, WHO reported that 56% of the population of 83 developing countries now had adequate access to iodized salt. This represents an increase of 750 million since 1990 with protection of 12 million children. (+info)

Thyroid stimulating hormone levels in cord blood are not influenced by non-thyroidal mothers' diseases. (6/303)

CONTEXT: Screening programs not only offer the opportunity to trace and treat almost all cases of congenital hypothyroidism but also mean large savings to the health system. However, carefully planned strategies are necessary to extend their benefits and reduce costs. OBJECTIVE: To determine the possible influence of maternal diseases that affect maternal-fetal placenta dynamics on primary thyroid stimulating hormone (TSH) screening for congenital hypothyroidism. DESIGN: Prospective non-randomized clinical trial with at least 3 months of follow-up. SETTING: A public university referral center [CAISM/Hospital das Clinicas, Faculty of Medicine, University of Campinas, Campinas, SP]. PARTICIPANTS: 415 neonates divided into 5 groups: eighty-three infants born from cardiac mothers; 98 from mothers that had toxemia; 54 of the mothers had diabetes mellitus; 40 were HIV positive and 140 had no diseases. INTERVENTION: All newborns had cord blood samples collected on filter paper at birth. MAIN MEASUREMENTS: TSH was measured from dried blood spots using a homemade immunofluorescence assay (sensitivity in dried blood spots = 0.1 mU/L). RESULTS: There was no significant difference in the mean TSH levels among the 5 groups. Moreover, TSH levels were around 5 mU/L in 48% of the newborns, indicating that our region is severely deficient in iodine. CONCLUSIONS: Our results indicate that primary TSH screening programs using cord blood are not affected by maternal diseases. We suggest that, besides its technical advantages over heel punctures with T4 primary approaches, neonatal screening using primary cord blood TSH may also be used as a monitoring tool for evaluation and control of iodine deficiency disorders (IDD). (+info)

Novel mutations of the thyroid peroxidase gene in patients with permanent congenital hypothyroidism. (7/303)

OBJECTIVE: It is suggested that iodide organification defects account for 10% of all cases with congenital hypothyroidism (CH). One candidate gene for these defects is the thyroid peroxidase (TPO) gene. DESIGN: Exons 2, 8-10 and 14 of the TPO gene were examined in 30 patients with permanent CH without a family history of CH. This group was characterized by the presence of an orthotopic thyroid gland and elevated TSH levels. METHODS: The mutational screening was performed by single-strand conformational polymorphism followed by sequence analysis of fragments with abnormal migration patterns and by restriction enzyme analysis. RESULTS: In four patients we were able to identify mutations on both alleles which have not been described so far. One patient was a carrier of a new homozygous point mutation in exon 9 resulting in an exchange from Leu to Pro at codon 458. Another patient was found to be compound heterozygous for two mutations, a 20 bp duplication in exon 2 and a new mutation in exon 9 (Arg491His). Two brothers of consanguineous parents showed a homozygous T deletion in exon 14 at position 2512. CONCLUSIONS: Our findings confirm the genetic heterogeneity of TPO defects and support the suggested prevalence of organification defects. (+info)

Longitudinal growth, sexual maturation and final height in patients with congenital hypothyroidism detected by neonatal screening. (8/303)

OBJECTIVE: To evaluate longitudinal growth, pubertal development and final height in patients with congenital hypothyroidism (CH) detected by a neonatal screening programme, and to identify factors potentially affecting growth outcome. PATIENTS: Fifty-five patients (41 females) detected by neonatal screening and followed longitudinally from the time of diagnosis and treatment (25+/-5 days) up to the age of 17+/-0.5 years were evaluated retrospectively. RESULTS: Pubertal development began and progressed normally in both males and females. In boys, a testicular volume of 4 ml was reached at 11.3+/-1.0 years. In girls breast enlargement (B2) occurred at a mean age of 10.3+/-1.2 years and the mean age of menarche was 12.5+/-1.2 years. The onset and the progression of puberty were independent of the aetiology, the severity of CH and the timing of the beginning of treatment. Girls treated with an initial amount of L-thyroxine (L-T4) greater than 8 microg/kg per day showed an earlier onset of puberty (B2 9.4+/-0.9 years; menarche 11.5+/-0.8 years) compared with girls treated with a lower initial dose of L-T4 (B2 10.5+/-1.2 years; menarche 12.6+/-1.2 years; P<0.02). However, both groups attained a similar final height (-0.1+/-1.0 SDS and 0.4+/-1.0 SDS, respectively), which in both cases was above the target height (P=0.03). All the patients in the study attained a mean final height (0.1+/-1.1 SDS) within the normal range for the reference population and above the target height (-0.9+/-0.9 SDS, P<0.0001). No significant relationship was found between final height and severity of CH at diagnosis, initial L-T4 dosage or aetiology of the defect. Patients with ectopic gland, thyroid aplasia or in situ gland attained a similar mean final height (0.1+/-1.1 SDS, 0.5+/-1.0 SDS and -0.5+/-1.0 SDS, respectively), which was in all cases greater than target height (-1.0+/-0.9, -0.6+/-0.8, -0.9+/-0.8 respectively; P<0.05). CONCLUSIONS: Our results suggest that conventional management of children with CH detected by neonatal screening leads to normal sexual development and normal adult height, and that the major factor determining height in these children is familial genetic growth potential. (+info)

... , copper engraving, 1815 Around the world, the most common cause of congenital hypothyroidism is ... Genetic types of nongoitrous congenital hypothyroidism include: Nongoitrous congenital hypothyroidism has been described as the ... levels to detect congenital hypothyroidism. Most children with congenital hypothyroidism correctly treated with thyroxine grow ... severe congenital hypothyroidism can lead to growth failure and permanent intellectual disability. Infants born with congenital ...

https://en.wikipedia.org/wiki/Congenital_hypothyroidism

a usually congenital condition marked by physical stunting and intellectual disability and caused by severe hypothyroidism ... Cretinism: Congenital hypothyroidism (underactivity of the thyroid gland at birth), which results in growth retardation, ... "Congenital hypothyroidism: MedlinePlus Genetics". medlineplus.gov. Retrieved 2022-10-20. Pass, K. A.; Neto, E. C. (2009). " ... It is one cause of underactive thyroid function at birth, called congenital hypothyroidism, historically referred to as ...

https://en.wikipedia.org/wiki/Congenital_iodine_deficiency_syndrome

Children with congenital hypothyroidism are treated supplementally with levothyroxine, which facilitates normal growth and ... Aberrations in prenatal development can result in various forms of thyroid dysgenesis which can cause congenital hypothyroidism ... Some forms of hypothyroidism can result in myxedema and severe cases can result in myxedema coma. Hypothyroidism is managed ... Infants with thyroid hormone deficiency (congenital hypothyroidism) can manifest problems of physical growth and development as ...

https://en.wikipedia.org/wiki/Thyroid

Tajima T, Nakamura A, Ishizu K (2013). "A novel mutation of IGSF1 in a Japanese patient of congenital central hypothyroidism ... Tajima T, Nakamura A, Ishizu K (2013). "A novel mutation of IGSF1 in a Japanese patient of congenital central hypothyroidism ... Tajima T, Nakamura A, Morikawa S, Ishizu K (Sep 2014). "Neonatal screening and a new cause of congenital central hypothyroidism ... Reynaert N, Braat E, de Zegher F (2015). "Congenital nystagmus and central hypothyroidism". International Journal of Pediatric ...

https://en.wikipedia.org/wiki/IGSF1

Bamforth JS, Hughes I, Lazarus J, John R (June 1986). "Congenital anomalies associated with hypothyroidism". Arch. Dis. Child. ... Bamforth JS, Hughes IA, Lazarus JH, Weaver CM, Harper PS (January 1989). "Congenital hypothyroidism, spiky hair, and cleft ... Kopp P (June 2002). "Perspective: genetic defects in the etiology of congenital hypothyroidism". Endocrinology. 143 (6): 2019- ...

https://en.wikipedia.org/wiki/Bamforth–Lazarus_syndrome

In young horses, congenital hypothyroidism has been reported predominantly in Western Canada and has been linked with the ... "hypothyroidism". Dictionary.com Unabridged (Online). n.d. "hypothyroidism - definition of hypothyroidism in English from the ... In the United States, hypothyroidism occurs in 0.3-0.4% of people. Subclinical hypothyroidism, a milder form of hypothyroidism ... tertiary hypothyroidism). Primary hypothyroidism is about a thousandfold more common than central hypothyroidism. Iodine ...

https://en.wikipedia.org/wiki/Hypothyroidism

"Lissencephaly presenting with congenital hypothyroidism". Journal of Pediatric Endocrinology and Metabolism. 26 (11-12): 1175-7 ... Congenital infections like cytomegalovirus are also known to cause microlissencephaly. Both microlissencephaly and microcephaly ... The combination of lissencephaly with severe congenital microcephaly is designated as microlissencephaly only when the cortex ... Microlissencephaly (MLIS) is a rare congenital brain disorder that combines severe microcephaly (small head) with lissencephaly ...

https://en.wikipedia.org/wiki/Microlissencephaly

Moltz KC, Postellon DC (1994). "Congenital hypothyroidism and mental development". Comprehensive Therapy. 20 (6): 342-346. PMID ... include measuring the level of TSH in the blood of a newborn infant as part of newborn screening for congenital hypothyroidism ...

https://en.wikipedia.org/wiki/Medical_test

The most commonly included disorders of the endocrine system are congenital hypothyroidism (CH) and congenital adrenal ... Congenital hypothyroidism was the second disease widely added in the 1970s. Guthrie and colleagues also developed bacterial ... Immunoassays measure thyroid hormones for the diagnosis of congenital hypothyroidism and 17α-hydroxyprogesterone for the ... Klein AH; Agustin AV; Foley TP (1974). "Successful laboratory screening for congenital hypothyroidism". Lancet. 2 (7872): 77-9 ...

https://en.wikipedia.org/wiki/Newborn_screening

1 in 5,000 Congenital hypothyroidism (CH) > 1 in 5,000 Biotinidase deficiency (BIOT) > 1 in 75,000 Congenital adrenal ... Some states are now screening for more than 50 congenital conditions. Many of these are rare and unfamiliar to pediatricians ... Severe combined immune deficiency (SCID) - added in 2009 Critical congenital heart defects (Screened using pulse oximetry) - ... 1 in 50,000 Newborn screening by other methods than blood testing Congenital deafness (HEAR) > 1 in 5,000 The following ...

https://en.wikipedia.org/wiki/List_of_disorders_included_in_newborn_screening_programs

New England congenital hypothyroidism collaborative (November 1981). "Effects of neonatal screening for hypothyroidism: ... In some countries, newborn babies are tested for congenital hypothyroidism and treated immediately if the disease is detected, ... Choufoer JC, Kassenaar AA, Querido A (July 1960). "The syndrome of congenital hypothyroidism with defective dehalogenation of ... Moreno JC (2003). "Identification of novel genes involved in congenital hypothyroidism using serial analysis of gene expression ...

https://en.wikipedia.org/wiki/Iodotyrosine_deiodinase

cite journal}}: Cite journal requires ,journal= (help) Bojanić, K; Acke, E; Jones, BR (2011-05-01). "Congenital hypothyroidism ... Dwarfism has the potential to be mistaken as congenital feline hypothyroidism. Signs such as disproportionate dwarfism, ... Jacobson, Teresa; Rochette, Judy (September 2018). "Congenital Feline Hypothyroidism With Partially Erupted Adult Dentition in ... such as congenital feline hypothyroidism, is causing symptoms similar to feline dwarfism. ...

https://en.wikipedia.org/wiki/Dwarf_cat

... has been shown to interact with NK2 homeobox 1. The PAX8 gene is also associated congenital hypothyroidism due to thyroid ... "Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism". The Biochemical Journal. 341 (1): 89-93. doi: ... in PAX8 associated with congenital hypothyroidism and thyroid hypoplasia: evidence for phenotypic variability in mother and ... "PAX8 mutations associated with congenital hypothyroidism caused by thyroid dysgenesis". Nature Genetics. 19 (1): 83-6. doi: ...

https://en.wikipedia.org/wiki/PAX8

Congenital hypothyroidism caused by thyroid dysgenesis can be associated with PAX8. An ectopic thyroid, also called accessory ... It should not be confused with iodine deficiency, or with other forms of congenital hypothyroidism, such as thyroid ... August 2002). "A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and ... Thyroid dysgenesis is a cause of congenital hypothyroidism where the thyroid is missing, ectopic, or severely underdeveloped. ...

https://en.wikipedia.org/wiki/Thyroid_dysgenesis

May 1999). "Young-Simpson syndrome: further delineation of a distinct syndrome with congenital hypothyroidism, congenital heart ... Young-Simpson syndrome (YSS) is a rare congenital disorder with symptoms including hypothyroidism, heart defects, facial ... Young ID, Simpson K (November 1987). "Unknown syndrome: abnormal facies, congenital heart defects, hypothyroidism, and severe ... In a smaller number of cases, thyroid agenesis, hypothyroidism, intestinal malrotation, and respiratory difficulties are ...

https://en.wikipedia.org/wiki/Young–Simpson_syndrome

... for developing a test for congenital hypothyroidism; biologist Yoshio Masui (1990) for work on cell division; physicist Kenneth ...

https://en.wikipedia.org/wiki/Manning_Innovation_Awards

... and congenital hypothyroidism". N. Engl. J. Med. 347 (2): 95-102. doi:10.1056/NEJMoa012752. PMID 12110737. Chávez V, Mohri- ...

https://en.wikipedia.org/wiki/Dual_oxidase_1

While at Indiana University, Rivkees initiated the Indiana Congenital Hypothyroidism Follow-up Program. While in Connecticut he ... For his work in the field of congenital adrenal hyperplasia and the publication of CAH: A Parent's Guide, he was awarded the ... He drafted seminal reports related to growth in juvenile acquired hypothyroidism, the use of radioactive iodine in the ... impacted clinical pediatric endocrinology with his description of the use of dexamethasone for the treatment of congenital ...

https://en.wikipedia.org/wiki/Scott_Rivkees

... and congenital hypothyroidism". N. Engl. J. Med. 347 (2): 95-102. doi:10.1056/NEJMoa012752. PMID 12110737. Geiszt M, Witta J, ... and congenital hypothyroidism". N. Engl. J. Med. 347 (2): 95-102. doi:10.1056/NEJMoa012752. PMID 12110737. "Entrez Gene: DUOX2 ... supported by the discovery of congenital hypothyroidism resultant from an inactivating mutation in the DUOX2 gene. The family ... Moreno JC, Visser TJ (2007). New phenotypes in thyroid dyshormonogenesis: hypothyroidism due to DUOX2 mutations. Endocrine ...

https://en.wikipedia.org/wiki/Dual_oxidase_2

The rigidity associated with congenital hypothyroidism may be due to abnormal development of basal ganglia. The muscle ... In hypothyroidism the fast twitch muscle fiber is converted to slow twitch fiber, causing the slower reflex or hung up reflex. ... Along with features of hypothyroidism the main additional feature is muscle hypertrophy. It can happen in any muscle of the ... The severity of these symptoms are determined by the period of hypothyroidism and the degree of deficiency of thyroid hormones ...

https://en.wikipedia.org/wiki/Kocher–Debre–Semelaigne_syndrome

2005). "Genetic analysis of TTF-2 gene in children with congenital hypothyroidism and cleft palate, congenital hypothyroidism, ... Mutations in this gene cause Bamforth-Lazarus syndrome and are associated with congenital hypothyroidism and cleft palate with ... 2003). "A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft ... 2006). "A novel missense mutation in human TTF-2 (FKHL15) gene associated with congenital hypothyroidism but not athyreosis". J ...

https://en.wikipedia.org/wiki/FOXE1

Delange also performed research for neonatal screening for congenital hypothyroidism, using TSH levels as a marker for ... He performed field studies on goiter prevalence worldwide and performed pioneering research in early screening for congenital ... hypothyroidism. Delange studied at the Free University of Brussels (ULB) and graduated as M.D. in 1960. In 1973, he completed ... hypothyroidism. Furthermore, Delange was promoting ThyroMobil, an initiative to perform standardized thyroid volume measurement ...

https://en.wikipedia.org/wiki/François_Delange

Causes, such as congenital hypothyroidism, if detected early may be treated to prevent the development of an intellectual ... congenital hypothyroidism, Williams syndrome, phenylketonuria (PKU), and Prader-Willi syndrome. Other genetic conditions ... It is not specific to congenital disorders such as Down syndrome. The American Association on Mental Retardation changed its ... India has 500 million people with a deficiency, 54 million with goiter, and 2 million with congenital iodine deficiency. Among ...

https://en.wikipedia.org/wiki/Intellectual_disability

2002). "Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the ... 2002). "Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect ... 2004). "Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: ... 2004). "Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in ...

https://en.wikipedia.org/wiki/TSHB

Johanson A, Blizzard R (December 1971). "A syndrome of congenital aplasia of the alae nasi, deafness, hypothyroidism, dwarfism ... Congenital deformations of the temporal bone and associated adverse anatomical effects on innervation and development of the ... Additional congenital anomalies, effects on other organs, and less common features of JBS have included: imperforate anus ( ... These include hypothyroidism, growth hormone deficiency and hypopituitarism. Findings affecting pituitary function in some ...

https://en.wikipedia.org/wiki/Johanson–Blizzard_syndrome

A delay in closure is associated with congenital hypothyroidism. Lambda (anatomy) This article incorporates text in the public ...

https://en.wikipedia.org/wiki/Posterior_fontanelle

... among other congenital disorders. Hypothesis: "The newborns have phenylketonuria and hypothyroidism" Null Hypothesis (H0): "The ... Type II error (false negative): The true fact is that the newborns have phenylketonuria and hypothyroidism but we consider they ... For example, most states in the USA require newborns to be screened for phenylketonuria and hypothyroidism, ... The true fact is that the newborns do not have phenylketonuria and hypothyroidism but we consider they have the disorders ...

https://en.wikipedia.org/wiki/Type_I_and_type_II_errors

Immunoassays measure thyroid hormones for the diagnosis of congenital hypothyroidism and 17α-hydroxyprogesterone for the ... Thangaratinam, S.; Brown, K.; Zamora, J.; Khan, K. S.; Ewer, A. K. (2012). "Pulse oximetry screening for critical congenital ... There is also bedside testing for hearing loss using evoked auditory potentials and congenital heart defects using pulse ... diagnosis of congenital adrenal hyperplasia. Molecular techniques are used for the diagnosis of cystic fibrosis and severe ...

https://en.wikipedia.org/wiki/Newborn_Screening_Saves_Lives_Reauthorization_Act_of_2013

... for the introduction of iodised salt to prevent endemic goitre and universal newborn screening for congenital hypothyroidism in ...

https://en.wikipedia.org/wiki/Nino_Salvatore

Congenital hypothyroidism Infant respiratory distress syndrome Interstitial lung disease Persistent pulmonary hypertension of ... In addition, hypothyroidism can cause damaged production of NKX2.1 proteins, which can lead to insufficient transcription of ... "Unexplained neonatal respiratory distress due to congenital surfactant deficiency". The Journal of Pediatrics. 150 (6): 649-53 ...

https://en.wikipedia.org/wiki/Surfactant_metabolism_dysfunction

Other possible causes of macroorchidism are long-standing primary hypothyroidism, adrenal remnants in congenital adrenal ...

https://en.wikipedia.org/wiki/Macroorchidism

... all US states currently test infants for phenylketonuria and congenital hypothyroidism. US state law mandates collecting a ...

https://en.wikipedia.org/wiki/Predictive_medicine

... fibrosis Congenital hepatic porphyria Congenital herpes simplex Congenital hypomyelination neuropathy Congenital hypothyroidism ... Congenital s Congenital megacolon Congenital megaloureter Congenital mesoblastic nephroma Congenital microvillous atrophy ... Congenital v Congenital toxoplasmosis Congenital unilateral pulmonary hypoplasia Congenital vagal hyperreflexivity Congenital ... Congenital mitral malformation Congenital mitral stenosis Congenital mixovirus Congenital mumps Congenital muscular dystrophy ...

https://en.wikipedia.org/wiki/List_of_diseases_(C)

... is typically used to treat hypothyroidism, and is the treatment of choice for people with hypothyroidism who ... Given that no increased risk of congenital abnormalities has been demonstrated in pregnant women taking levothyroxine, therapy ... Levothyroxine is safe and effective for children with hypothyroidism; the goal of treatment for children with hypothyroidism is ... Hypothyroidism is common among pregnant women. A nationwide cohort study showed that 1.39% of all pregnant women in 2010 in ...

https://en.wikipedia.org/wiki/Levothyroxine

... or severe anemia Children with achondroplasia and congenital iodine deficiency Children after a severe episode of enteritis ... Pernicious anemia Aplastic anemia Wilson's disease Hypothyroidism Zinc deficiency Malnutrition Steroid treatment Colitis ...

https://en.wikipedia.org/wiki/Alkaline_phosphatase

"Hypothyroidism And Spontaneous Abortions Among Hanford, Washington, Downwinders." Archives Of Environmental Health 51.3 (1996 ... and possibly female reproductive cancers that could lead to congenital malformations have been observed in Hanford "downwind" ...

https://en.wikipedia.org/wiki/Downwinders

... congenital iodine deficiency syndrome resulting from congenital hypothyroidism (underactive thyroid), and that they were part ... Congenital iodine deficiency syndrome, caused by iodine deficiency, is expressed by small bodies and reduced brain size (but ME ... A 2012 study similar to Groves and FitzGeralds' also found no evidence of congenital iodine deficiency syndrome. In 2014, ... In 2008 Australian researcher Peter Obendorf-who studies congenital iodine deficiency syndrome-and colleagues suggested that ...

https://en.wikipedia.org/wiki/Homo_floresiensis

Congenital erosive and vesicular dermatosis Congenital hypertrophy of the lateral fold of the hallux Congenital lip pit ( ... Hyperparathyroidism Hyperprolactinemic SAHA syndrome Hyperthyroidism Hypoparathyroidism Hypothyroidism Leydig cell tumor ... congenital constriction bands, pseudoainhum) Aplasia cutis congenita (cutis aplasia, congenital absence of skin, congenital ... congenital auricular fistula, congenital preauricular fistula, preauricular cyst) Rapidly involuting congenital hemangioma ( ...

https://en.wikipedia.org/wiki/List_of_skin_conditions

... cramps Hypothyroidism, adrenal insufficiency, hypogonadism, diabetes mellitus Dozens of congenital metabolic diseases are now ... Following are some of the major classes of congenital metabolic diseases, with prominent examples of each class. Disorders of ... Inborn errors of metabolism form a large class of genetic diseases involving congenital disorders of enzyme activities. The ... Inborn errors of metabolism are now often referred to as congenital metabolic diseases or inherited metabolic disorders. To ...

https://en.wikipedia.org/wiki/Inborn_errors_of_metabolism

These conditions include tongue-tie, congenital heart defects, prematurity, and Down syndrome. Primary causes of low milk ... hypothyroidism hypoprolactinemia theca lutein cysts hypertension pregnancy Smoking more than 15 cigarettes per day is ...

https://en.wikipedia.org/wiki/Low_milk_supply

It is classically delayed in hypothyroidism. This reflex is usually absent in disk herniations at the L5-S1 level. A reduction ... neuropathy Abetalipoproteinemia Electrolyte abnormalities Hypokalemia Deficiency disorders Vitamin E deficiency Congenital ... Lumbar herniated disk syndrome Lumbar spinal stenosis Endocrine disorders Hypothyroidism Sciatic neuropathy Lumbosacral plexus ...

https://en.wikipedia.org/wiki/Ankle_jerk_reflex

HIV encephalopathy Meningitis Encephalitis Toxins Chronic kidney failure Deprivation Hypothyroidism Anemia Congenital heart ... Vertically transmitted infections Congenital cytomegalovirus infection Toxoplasmosis Congenital rubella syndrome Congenital ... "Congenital Disorders of Glycosylation". NORD (National Organization for Rare Disorders). Retrieved 2019-08-01. "Mito Info". ... The spread of Aedes mosquito-borne Zika virus has been implicated in increasing levels of congenital microcephaly by the ...

https://en.wikipedia.org/wiki/Microcephaly

... congenital, nongoitrous 4; 275100; TSHB Hypothyroidism, congenital nongoitrous, 5; 225250; NKX2E Hypothyroidism, congenital, ... GUCY2D Leber congenital amaurosis 10; 611755; CEP290 Leber congenital amaurosis 12; 610612; RD3 Leber congenital amaurosis 13; ... LRAT Leber congenital amaurosis 2; 204100; RPE65 Leber congenital amaurosis 3; 604232; SPATA7 Leber congenital amaurosis 4; ... congenital; 604219; BFSP2 Cataract, congenital, cerulean type, 3; 608983; CRYGD Cataract, congenital, X-linked; 302200; NHS ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

A rare form of HA that presents as primary amenorrhea can be due to a congenital deficiency of GnRH knows as idiopathic ... For instance, women with hyper- or hypothyroidism sometimes have ovulation problems. Thyroid dysfunction can halt ovulation by ... A 17-hydroprogesterone test may also be conducted if congenital adrenal hyperplasia is suspected. If the differential is broad ...

https://en.wikipedia.org/wiki/Anovulation

In 2004, Brent proposed a set of criteria for identifying causes of congenital malformations that also are applicable to ... childhood cancers Environmental exposure to perchlorate in women with hypothyroidism causes a significant risk of low IQ in the ... Toxic substances that are capable of causing structural congenital abnormalities can be termed teratogens. They are agents ... Low birth weight, preterm birth, intrauterine growth retardation, and congenital abnormalities have all been found to be ...

https://en.wikipedia.org/wiki/Environmental_toxicants_and_fetal_development

Patients with hypothyroidism frequently present with changes in their menstrual cycle. It is hypothesized that this is due to ... It may be caused by developmental problems, such as the congenital absence of the uterus, failure of the ovary to receive or ... Abnormal TSH levels prompt evaluation for hyper- and hypo-thyroidism with additional thyroid function tests. Elevated prolactin ... 17-hydroxyprogesterone is elevated in congenital adrenal hyperplasia. Elevated testosterone and amenorrhea can suggest PCOS. ...

https://en.wikipedia.org/wiki/Amenorrhea

The cause of congenital third-degree heart block in many patients is unknown. Studies suggest that the prevalence of congenital ... block caused by hyperkalemia should be treated to lower serum potassium levels and patients with hypothyroidism should also ... Third-degree heart block may also be congenital and has been linked to the presence of lupus in the mother. It is thought that ...

https://en.wikipedia.org/wiki/Third-degree_atrioventricular_block

The most common congenital cause of thymus-related immune deficiency results from the deletion of the 22nd chromosome, called ... with the commonly affected organs being hypothyroidism of the thyroid gland, Addison's disease of the adrenal glands, and ... The usual reason for removal is to gain access to the heart for surgery to correct congenital heart defects in the neonatal ... As the thymus is where T cells develop, congenital problems with the development of the thymus can lead to immunodeficiency, ...

https://en.wikipedia.org/wiki/Thymus

His 2006 outdoor season was brief due to the onset of hypothyroidism. Rupp came back in 2006 to defeat two-time Pac-10 champion ... Haglund's Deformity is thought to be a congenital disorder. Rupp has the bumps on both heels, although to date only the left ...

https://en.wikipedia.org/wiki/Galen_Rupp

... may result from the sail vertebrae associated with cretinism (the childhood form of hypothyroidism), ... hereditary and congenital conditions, and physical trauma to the spine that results in injury. ... mucopolysaccharidosis (MPS), and certain congenital syndromes, including achondroplasia. Because most children with MPS I ( ...

https://en.wikipedia.org/wiki/Gibbus_deformity

... congenital hypothyroidism MeSH C05.116.099.343.445 - dwarfism, pituitary MeSH C05.116.099.343.679 - Laron syndrome MeSH C05.116 ... congenital hypothyroidism MeSH C05.116.132.358 - dwarfism, pituitary MeSH C05.116.132.479 - gigantism MeSH C05.116.132.684 - ... congenital MeSH C05.660.585.512.380 - foot deformities, congenital MeSH C05.660.585.600 - polydactyly MeSH C05.660.585.600.750 ... congenital MeSH C05.660.585.988.425 - hand deformities, congenital MeSH C05.660.906.364 - craniosynostoses MeSH C05.660.906.364 ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C05)

... a speed-up technique for finding shortest paths in a graph Cluster headache Cholesterol Congenital hypothyroidism, a condition ...

https://en.wikipedia.org/wiki/CH

Congenital adrenal hyperplasia, a group of autosomal recessive disorders of the enzymes responsible for steroid hormone ... an excessive secretion of glucocorticoids causes the hypertension Hyperparathyroidism Acromegaly Hyperthyroidism Hypothyroidism ...

https://en.wikipedia.org/wiki/Secondary_hypertension

DiGeorge, A (1968). "Congenital absence of the thymus and its immunologic consequences: concurrence with congenital ... Disorders such as hypothyroidism and hypoparathyroidism or thrombocytopenia (low platelet levels), and psychiatric illnesses ... Characteristic signs and symptoms may include birth defects such as congenital heart disease, defects in the palate, most ... While the symptoms can vary, they often include congenital heart problems, specific facial features, frequent infections, ...

https://en.wikipedia.org/wiki/DiGeorge_syndrome

... such as hypothyroidism, congenital adrenal hyperplasia (21-hydroxylase deficiency), Cushing's syndrome, hyperprolactinemia, ... These tests should be followed by tests for hypothyroidism, hyperprolactinemia, and adrenal hyperplasia. Loh HH, Yee A, Loh HS ... New MI (May 1993). "Nonclassical congenital adrenal hyperplasia and the polycystic ovarian syndrome". Annals of the New York ... Other conditions that produce similar symptoms include adrenal hyperplasia, hypothyroidism, and high blood levels of prolactin ...

https://en.wikipedia.org/wiki/Polycystic_ovary_syndrome

... congenital hypothyroidism) Sepsis or other infectious causes Transient neonatal jaundice is one of the most common conditions ...

https://en.wikipedia.org/wiki/Jaundice

Buyon JP, Clancy RM (December 2003). "Maternal autoantibodies and congenital heart block: mediators, markers, and therapeutic ... is probably multifactorial and has been related to not only disease activity or complications such as anemia or hypothyroidism ...

https://en.wikipedia.org/wiki/Lupus

... increase in cases of congenital hypothyroidism (CH) in 5 US states in the 10 months following the disaster. This study was ...

https://en.wikipedia.org/wiki/Radiation_and_Public_Health_Project

... hypothyroidism) that affects infants from birth (congenital). Explore symptoms, inheritance, genetics of this condition. ... Congenital hypothyroidism is a partial or complete loss of function of the thyroid gland ( ... Genetic Testing Registry: Hypothyroidism, congenital, nongoitrous, 1 *Genetic Testing Registry: Hypothyroidism, congenital, ... medlineplus.gov/genetics/condition/congenital-hypothyroidism/ Congenital hypothyroidism. ...

https://medlineplus.gov/genetics/condition/congenital-hypothyroidism

A Utah study reveals the value of a two-screen approach in identifying congenital hypothyroidism cases in newborns. ... A Utah study reveals the value of a two-screen approach in identifying congenital hypothyroidism cases in newborns. ... Confirmed congenital hypothyroidism with abnormal TSH levels on first screen.. § Confirmed congenital hypothyroidism with ... as well as a clinical diagnosis of congenital hypothyroidism.. Among 130 confirmed cases of congenital hypothyroidism ...

https://www.cdc.gov/mmwr/volumes/67/wr/mm6728a4.htm

What Is Congenital Hypothyroidism?. Kids can have hypothyroidism too. When a baby is born with it, its called congenital ... What Causes Congenital Hypothyroidism?. Most cases of congenital hypothyroidism happen because the thyroid doesnt form ... What Are the Signs & Symptoms of Congenital Hypothyroidism?. Early signs of congenital hypothyroidism in a baby include:. * ... How Is Congenital Hypothyroidism Treated?. A child with hypothyroidism will take thyroid hormone to make up for what the ...

https://www.kidshealth.org/HospitalSantJoandeDeu/en/parents/congenital-hypothyroidism.html

There was a significant association between parental consanguinity and congenital hypothyroidism [‎P = 0.006]‎; congenital ... Parental consanguinity among parents of neonates with congenital hypothyroidism in Isfahan. View/. Open. 13_3_2007_567_574.pdf ... We determined the prevalence of congenital hypothyroidism and the rate of consanguinity among parents of hypothyroid neonates ... 2007)‎. Parental consanguinity among parents of neonates with congenital hypothyroidism in Isfahan. EMHJ - Eastern ...

https://extranet.who.int/iris/restricted/handle/10665/117285

https://teenshealth.org/en/parents/congenital-hypothyroidism.html

Newborn Screening in China: Phenylketonuria, Congenital Hypothyroidism and Expanded Screening. Xuefan Gu, Zhiguo Wang, Jun Ye, ...

https://annals.edu.sg/newborn-screening-in-china-phenylketonuria-congenital-hypothyroidism-and-expanded-screening/

Congenital hypothyroidism. Approximately 75% of infants with congenital hypothyroidism have defects in thyroid gland ... Hypothyroidism is among the most common endocrine diseases. Congenital hypothyroidism most frequently results from agenesis, ... Congenital hypothyroidism can present with goiter at birth or with the gradual development of symptoms over the first several ... Congenital hypothyroidism: etiology and growth-development outcome. Acta Med Iran. 2014 Oct. 52(10):752-6. [QxMD MEDLINE Link] ...

http://emedicine.medscape.com/article/922777-overview

Molecular Analysis of Giant Schnauzer-Type Congenital Hypothyroidism. Isolated congenital hypothyroidism (CH) is a condition ...

https://www.pwdfoundation.org/project/molecular-analysis-giant-schnauzer-type-congenital-hypothyroidism/

Evolution of congenital hypothyroidism with in situ thyroid gland in children and adolescents. Luisa Pignata , Brunella ... Evolution of congenital hypothyroidism with ,em,in situ,/em, thyroid gland in children and adolescents (. ... Background: In recent years, increasing cases of congenital hypothyroidism (CH) with in situ thyroid gland are identified. ... Results: 48 patients performed clinical reassessment: 10 had overt hypothyroidism (20.8%), 20 showed hyperthyrotropinemia (41.7 ...

https://www.endocrine-abstracts.org/ea/0081/ea0081p701

Identification of Primary Congenital Hypothyroidism Based on Two Newborn Screens - Utah, 2010-2016 Cite ... The study objective was to evaluate screening consequences for primary congenital hypothyroidism (CH) in one- and two-screen ... Newborn screening for primary congenital hypothyroidism is part of the U.S. Recommended Uniform Screening Panel (1,2). ... When newborn screening (NBS) for congenital hypothyroidism (CH) using thyroid-stimulating hormone (TSH) as a primary screening ...

https://stacks.cdc.gov/view/cdc/36454

CALDONAZZO, Anelise et al. Assisted assessment in children with congenital hypothyroidism. Rev. psicopedag. [online]. 2009, vol ... Palavras-chave : Problem solving; Congenital hypothyroidism; Educational measurement; Cognition. · resumo em Português · texto ... The objective of this study was to evaluate the executive functioning of children diagnosed with congenital hypothyroidism ...

http://pepsic.bvsalud.org/scielo.php?script=sci_abstract&pid=S0103-84862009000300008&lng=pt&nrm=iso&tlng=en

Congenital Hypothyroidism and Nephrocalcinosis. Indian Pediatrics. 2010 Mar; 47(3): 281.. URI: http://imsear.searo.who.int/ ...

https://imsear.searo.who.int/handle/123456789/168446

"Effects of immigration on the incidence of congenital hypothyroidism",. abstract = "Objective: The incidence of congenital ... Kaiserman I, Maytal A, Siebner R, Sack J. Effects of immigration on the incidence of congenital hypothyroidism. European ... Kaiserman, I, Maytal, A, Siebner, R & Sack, J 1997, Effects of immigration on the incidence of congenital hypothyroidism, ... Effects of immigration on the incidence of congenital hypothyroidism. In: European Journal of Endocrinology. 1997 ; Vol. 137, ...

https://cris.bgu.ac.il/en/publications/effects-of-immigration-on-the-incidence-of-congenital-hypothyroid

Neonatal Screening for Congenital Hypothyroidism : What Can We Learn from Discordant Twins. / Medda, Emanuela; Vigone, Maria ... Neonatal Screening for Congenital Hypothyroidism: What Can We Learn from Discordant Twins. Journal of Clinical Endocrinology ... Neonatal Screening for Congenital Hypothyroidism : What Can We Learn from Discordant Twins. In: Journal of Clinical ... Dive into the research topics of Neonatal Screening for Congenital Hypothyroidism: What Can We Learn from Discordant Twins. ...

https://moh-it.pure.elsevier.com/en/publications/neonatal-screening-for-congenital-hypothyroidism-what-can-we-lear

Find out how levothyroxine therapy affects inflammatory biomarkers in patients with hypothyroidism. ... What Are the Guideline Updates for Congenital Hypothyroidism? 0.5 CME / CE / ABIM MOC Credits Clinical Review ... The hypothyroidism status (i.e., overt or subclinical hypothyroidism) was included as a confounder in all analyses. An ... Methods: In this prospective open-label study, 17 patients with recently diagnosed primary hypothyroidism due to Hashimotos ...

https://www.medscape.com/viewarticle/847670

... is a disease in which the thyroid gland starts to produce insufficient ... Untreated congenital hypothyroidism in newborns leads to learning difficulties and behavioral problems later on in childhood. ...

http://www.handballinafrica.org/congenital-hypothyroidism.html

TextPublication details: São Paulo : Ache, 1986. Description: 317 pSubject(s): Goiter , Hypothyroidism -- congenitalNLM ... Iodine deficiency disorders and congenital hypothyroidism / Geraldo Medeiros-Neto, Rui M. B. Maciel, Alfredo Halpern, editors. ...

https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=ccl=au%3A%22Medeiros-Neto%2C%20Geraldo%20A.%22&sort_by=relevance_dsc&count=20&limit=au:Halpern,%20Alfredo

Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism. Biochemical Journal. 1999 Jul 1;341(1):89-93. ... Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism. In: Biochemical Journal. 1999 ; Vol. 341, No. ... Dive into the research topics of Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism. Together ... Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism. / Tell, Gianluca; Pellizzari, Lucia; Esposito ...

https://nyuscholars.nyu.edu/en/publications/structural-defects-of-a-pax8-mutant-that-give-rise-to-congenital-

Parental consanguinity among parents of neonates with congenital hypothyroidism in Isfahan Khatibi, K.H.; Haghigh, S.; Salek ... We determined the prevalence of congenital hypothyroidism and the rate of consanguinity among parents of hypothyroid neonates ...

https://apps.who.int/iris/handle/10665/115916/browse?locale-attribute=ar&type=title&etal=-1&sort_by=1&rpp=20&starts_with=P&order=ASC

Genetics of Primary Congenital HypothyroidismAuthors:Nitash Zwaveling-Soonawala, MD, A.S. Paul van Trotsenburg, MD, PhD ...

https://www.pediatricendoreviews.com/product-page/genetics-of-primary-congenital-hypothyroidism

... congenital hypothyroidism, sickle-cell diseases, congenital adrenal hyperplasia, biotinidase deficiency and 12 amino acid, ... Congenital hypothyroidism. A total of 513 infants who screened positive for CH were further investigated and followed up; these ... Neonatal screening for congenital hypothyroidism. Incidence, imaging, feasibility and difficulties of a nationwide programme. ... The incidence of screened disorders were 1:1 873 for congenital hypothyroidism, 1:14 544 for phenylketonuria, 1:3 526 for amino ...

http://www.emro.who.int/ar/emhj-vol-20-2014/volume-20-issue-1/expanding-the-comprehensive-national-neonatal-screening-programme-in-the-united-arab-emirates-from-1995-to-2011.html

... on Congenital Hypothyroidism recommends thyroid imaging for all babies with suspected congenital hypothyroidism because:. *It ... Neurodevelopmental outcomes in congenital hypothyroidism: comparison of initial T4 dose and time to reach target T4 and TSH. J ... Congenital hypothyroidism in Scotland, guidelines for the management of. exp date isnt null, but text field is ... Congenital hypothyroidism in Scotland, guidelines for the management of * Diabetes insipidus diagnosis and management ( ...

https://clinicalguidelines.scot.nhs.uk/nhsggc-guidelines/nhsggc-guidelines/endocrinology/congenital-hypothyroidism-in-scotland-guidelines-for-the-management-of/

Congenital Hypothyroidism (CHG) is one of the hereditary diseases that is an endocrine disorder characterized by inadequate T4 ... levels early in life concurrent with signs of hypothyroidism. The EVG has the best DNA test for dogs with a DNA test kit that ... Congenital Hypothyroidism (CHG) is a DNA test for Hereditary diseases. ... Congenital Hypothyroidism (CHG) - Spanish Water Dog. Congenital Hypothyroidism (CHG) is a DNA test for Hereditary diseases. ...

https://eurovetgene.com/congenitale-hypothyreose-chg-spanischer-wasserhund

What Are the Guideline Updates for Congenital Hypothyroidism? 0.5 CME / CE / ABIM MOC Credits Clinical Review ... Congenital Hypothyroidism. Initial: 5 mcg PO qDay; may increase by 5 mcg q3-4Days ... Hypothyroidism Prevalence in the United States * Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and ... Hypothyroidism. Initial: 25 mcg PO qDay; may increase by 25 mcg q1-2Weeks; not to exceed 100 mcg/day ...

http://reference.medscape.com/drug/cytomel-triostat-liothyronine-342733

In patients with congenital hypothyroidism, assess the adequacy of replacement therapy by measuring both serum TSH and total or ... Congenital Hypothyroidism [See Dosage and Administration (2.3, 2.4)] Rapid restoration of normal serum T4 concentrations is ... Pediatric Dosage - Congenital or Acquired Hypothyroidism The recommended daily dose of levothyroxine sodium tablets in ... Hypothyroidism: As replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or ...

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=d5f5465f-61bb-7aaa-e053-2a95a90a8c3d&type=display

Unliganded receptor activity is, therefore, probably an important factor in causing the harmful effects of hypothyroidism. ... Congenital hypothyroidism impairs spine growth of dentate granule cells by downregulation of CaMKIV *Qingying Tang ... 1989) Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid ... 2002) Congenital hypothyroid Pax8(−/−) mutant mice can be rescued by inactivating the TRα gene. Mol Endocrinol 16: 24-32 ...

https://www.nature.com/articles/ncpendmet0424?error=cookies_not_supported&code=37259e76-4795-4d04-9164-3245e9bca0d6

Congenital hypothyroidism in newborns is characterized by lack of thyroid gland hormones, which play an important role in brain ... Congenital hypothyroidism in newborns is characterized by lack of thyroid gland hormones, which play an important role in brain ... congenital hydrocephaly, Down syndrome, conjunctivitis, congenital hypothyroidism, congenital heart defect (patent arterial ... Congenital hypothyroidism is one of the most common congenital pathology of endocrine system in newborns. Among other diseases ...

https://crimsonpublishers.com/rpn/fulltext/RPN.000585.php

Congenital Hypothyroidism. Congenital hypothyroidism affects a ratio of 1 in 4000 newborn babies and used to be a major cause ... Screening for congenital hypothyroidism is routine in Canada. A thyroid blood test (TSH or T4) is routinely done on a small ... In infants with congenital hypothyroidism, the thyroid gland, for reasons unknown, may either fail to develop or be much ... About 10% of infants with congenital hypothyroidism will have an inherited inability to make thyroid hormone although the ...

https://thyroid.ca/resource-material/information-on-thyroid-disease/thyroid-disease-in-childhood/

Incidence of congenital hypothyroidism and associated congenital anomalies at VSS Medical College & Hospital, Burla . Int J ... Incidence of congenital hypothyroidism and associated congenital anomalies at VSS Medical College & Hospital, Burla ... Objective: to know the incidence of Congenital Hypothyroidism and associated congenital anomalies in this part of the country, ... In a study carried out at Israel found 15.6% cases of Congenital Hypothyroidism were associated with congenital anomalies ...

https://www.paediatricjournal.com/archives/2020.v3.i2.C.111

Screening for Congenital Hypothyroidism (1991), by Delbert A. Fisher. In his 1991 article Screening for Congenital ... Fisher in the US reported on the implementation and impact of mass neonatal screening programs for congenital hypothyroidism ( ... Congenital club foot is a birth deformity in which one or both of an infants feet are rotated inward beneath the ankle, making ... Ignacio Vives Ponseti developed a noninvasive method for treating congenital club foot in the US during the late 1940s. ...

https://embryo.asu.edu/search?text=University%20of%20Pittsburgh&%3Bamp%3Bf%5B0%5D=dc_subject_embryo%3A6921&%3Bf%5B0%5D=dc_description_type%3A1&f%5B0%5D=dc_subject_embryo%3A44&f%5B1%5D=dc_description_type%3A35

ABSTRACT The national neonatal screening programme in the United Arab Emirates currently includes 16 disorders: congenital hypothyroidism, sickle-cell diseases, congenital adrenal hyperplasia, biotinidase deficiency and 12 amino acid, organic acid and fatty acid disorders. (who.int)
The incidence of screened disorders were 1:1 873 for congenital hypothyroidism, 1:14 544 for phenylketonuria, 1:3 526 for amino acid, organic acid and fatty acid disorders, 1:9 030 for classical congenital adrenal hyperplasia, 1:8 300 for biotinidase deficiency, 1:2 384 for sickle-cell disease and 1:121 for sickle-cell traits. (who.int)
Congenital adrenal hyperplasia is the name given to a group of inherited disorders of the adrenal gland. (limamemorial.org)
Further, in the United States, every new baby is now screened for congenital adrenal hyperplasia as well as congenital hypothyroidism. (mhmedical.com)
Congenital adrenal hyperplasia- 10-20 mg/m 2 /day in 3 divided doses. (drugguide.com)

Genetic causes account for about 15 to 20 percent of cases of congenital hypothyroidism. (medlineplus.gov)
Most cases of congenital hypothyroidism are sporadic, which means they occur in people with no history of the disorder in their family. (medlineplus.gov)
Most cases of congenital hypothyroidism happen because the thyroid doesn't form correctly in the baby during pregnancy. (kidshealth.org)
Background: In recent years, increasing cases of congenital hypothyroidism (CH) with in situ thyroid gland are identified. (endocrine-abstracts.org)
In a study carried out at Israel found 15.6% cases of Congenital Hypothyroidism were associated with congenital anomalies majority being cardiac anomalies. (paediatricjournal.com)

Without treatment, children with congenital hypothyroidism can develop permanent mental disabilities. (kidshealth.org)
Children with congenital hypothyroidism can sometimes develop hearing problems. (kidshealth.org)
To give guidance for ongoing management and monitoring of infants and children with congenital hypothyroidism. (scot.nhs.uk)

Iodine deficiency disorders and congenital hypothyroidism / Geraldo Medeiros-Neto, Rui M. B. Maciel, Alfredo Halpern, editors. (who.int)
On the other hand, Hypothyroidism can occur due to any one of the reasons like congenital thyroid abnormalities, autoimmune disorder such as Hashimoto's thyroiditis, iodine deficiency or due to removal of the thyroid gland. (dynamichomeopath.com)

Hypothyroidism is among the most common endocrine diseases. (medscape.com)
Congenital hypothyroidism with goiter (CHG) in Spanish Waterdog is an endocrine disorder characterized by inadequate T4 levels early in life concurrent with signs of hypothyroidism. (eurovetgene.com)
Congenital hypothyroidism is one of the most common congenital pathology of endocrine system in newborns. (crimsonpublishers.com)
I think this is an interesting and important study and further studies are needed to clarify the optimal way to treat hypothyroidism," said Farwell, who is director of Endocrine Clinics at Boston University School of Medicine, Massachusetts. (medscape.com)
Congenital hypothyroidism (CH) is the most common endocrine pathology in neonates. (ebyu.edu.tr)
Primary congenital hypothyroidism (CH) is the most common neonatal endocrine defect, and delayed diagnosis can result in significant neurodevelopmental impairment. (endocrinology.org)

Congenital hypothyroidism in this breed is often presented with goiter - a swelling in the neck resulting from an enlarged thyroid gland. (eurovetgene.com)
Many animals with goiter appear to remain euthyroid, but clinical signs of hypothyroidism may develop in some, especially in newborns. (merckvetmanual.com)
therefore, goiter is in no way synonymous with hypothyroidism. (merckvetmanual.com)

In the United States and many other countries, all hospitals test newborns for congenital hypothyroidism. (medlineplus.gov)
Congenital hypothyroidism affects an estimated 1 in 2,000 to 4,000 newborns. (medlineplus.gov)
Untreated congenital hypothyroidism in newborns leads to learning difficulties and behavioral problems later on in childhood. (handballinafrica.org)
Congenital hypothyroidism in newborns is characterized by lack of thyroid gland hormones, which play an important role in brain formation and development during pre- and postnatal period. (crimsonpublishers.com)
Newborns are tested at birth for hypothyroidism. (ahealthyme.com)
In addition to blood tests, screening for hearing loss and critical congenital heart disease (CCHD) is recommended for all newborns. (limamemorial.org)
All newborns in the U.S. are tested for congenital hypothyroidism. (medlineplus.gov)
Routine testing at birth uncovers hypothyroidism in one in every 1,500-3,000 newborns . (bluecrestwellness.com)

This article represents a clinical case of congenital hypothyroidism diagnosed on its early stage. (crimsonpublishers.com)
We present a unique case of congenital hypothyroidism with optic nerve head cupping presenting as a plausible variant of optic nerve hypoplasia. (ijoreports.in)

Most infants with congenital hypothyroidism are asymptomatic during the neonatal period or display subtle and nonspecific symptoms of thyroid hormone deficiency. (medscape.com)
In infants with congenital hypothyroidism, the thyroid gland, for reasons unknown, may either fail to develop or be much smaller than normal. (thyroid.ca)
About 10% of infants with congenital hypothyroidism will have an inherited inability to make thyroid hormone although the thyroid gland is present (congenital goitre). (thyroid.ca)

Signs and symptoms of congenital hypothyroidism result from the shortage of thyroid hormones. (medlineplus.gov)
What Are the Signs & Symptoms of Congenital Hypothyroidism? (kidshealth.org)
Patients with hypothyroidism treated with the three most common pharmacological strategies of levothyroxine (LT4) alone, LT4 in combination with triiodothyronine (T3), or desiccated thyroid extract showed no differences in thyroid symptoms or secondary outcomes in a double-blind randomized study. (medscape.com)
There are now proven good treatment options for the more than one in 10 patients with hypothyroidism who continue to experience symptoms of fatigue, mental fogginess, weight gain, and other symptoms despite taking levothyroxine," first author Thanh Duc Hoang, DO, an endocrinologist at the Walter Reed National Military Medical Center, in Bethesda, Maryland, said in a press statement. (medscape.com)
While symptoms of hypothyroidism usually begin to resolve within two weeks of initiating treatment, it takes about six weeks for TSH levels to stabilize. (verywellhealth.com)
When a person has hypothyroidism, they struggle with symptoms related to insufficient cellular energy. (palomahealth.com)
This 6-week-old female presented with symptoms of jaundice, which was proven to be due to hypothyroidism. (cdc.gov)
The symptoms of hypothyroidism are introduced on if the gland slows or entirely ceases the manufacture of thyroid hormones. (yourfirsthealthcare.com)

Since then, screening has expanded to testing for Congenital Hypothyroidism, Cystic Fibrosis, Phenylketonuria, and over 20 other rare conditions. (rch.org.au)

Congenital Hypothyroidism (CHG) is a DNA test for Hereditary diseases. (eurovetgene.com)
Problems with these organs underlie benign hereditary chorea, respiratory distress syndrome, congenital hypothyroidism, and other features of brain-lung-thyroid syndrome. (medlineplus.gov)

Studies of other congenital diseases have shown that immigrants tend to retain the incidence of their country of origin while their children acquire the incidence of their new homeland, suggesting an environmental influence. (bgu.ac.il)
Among other diseases causing nervous system disorders in children, congenital hypothyroidism provides most promising treatment results for further child development. (crimsonpublishers.com)
In addition, this finding could be used to treat various congenital heart diseases, heart failure, pulmonary hypertension, and heart attacks. (pharmalabglobal.com)

Proper dose titration and careful monitoring is critical to prevent the persistence of hypothyroidism or the development of hyperthyroidism. (nih.gov)
Thyroid problems can be categorized in three categories- overactive thyroid or hyperthyroidism and underactive thyroid or hypothyroidism and thyroid cancer. (dynamichomeopath.com)

5. Any congenital anomaly or disorder (e.g. diagnosed inborn error of metabolism, congenital cardiac disease, seizure disorders, hypothyroidism, Down's syndrome etc. (who.int)

Screening for congenital hypothyroidism is conducted by all newborn screening programs in the United States. (cdc.gov)
Retrospective analysis of 7 years of Utah newborn screening data found that 20% of congenital hypothyroidism cases were in infants who had normal thyroid-stimulating hormone (TSH) concentrations on the first screen but elevated TSH concentrations on the second screen. (cdc.gov)
Newborn screening for primary congenital hypothyroidism is part of the U.S. Recommended Uniform Screening Panel ( 1 , 2 ). (cdc.gov)
Initial newborn screening for congenital hypothyroidism is typically performed 24-48 hours after birth. (cdc.gov)
A retrospective examination of Utah's screening data indicated that 20% of congenital hypothyroidism cases could not have been efficiently identified by a single screen alone. (cdc.gov)
Newborn screening for congenital hypothyroidism in Utah is accomplished by measuring thyroid-stimulating hormone (TSH) from dried whole blood spots collected on a newborn screening card by heel stick. (cdc.gov)
Serum thyrotropin (TSH) concentration remains the most sensitive screening test for hypothyroidism and for establishing the diagnosis of primary hypothyroidism. (medscape.com)
Newborn screening program for congenital hypothyroidism (CH) adopting rescreening in at-risk neonates. (elsevier.com)
During long-term follow-up (range, 3 to 21 years), hypothyroidism was diagnosed in two monozygotic screening negative cotwins at the age of 9 months and 12 years, respectively. (elsevier.com)
To diagnose the cause of congenital hypothyroidism following positive screening. (scot.nhs.uk)
Screening for congenital hypothyroidism is routine in Canada. (thyroid.ca)
In his 1991 article Screening for Congenital Hypothyroidism, Delbert A. Fisher in the US reported on the implementation and impact of mass neonatal screening programs for congenital hypothyroidism (CH) from the early 1970s through 1991. (asu.edu)
True incidence of congenital hypothyroidism in Pakistan is unknown due to lack of community surveys and long awaited national newborn screening program for hypothyroidism. (annalskemu.org)
In their paper on the TSH threshold in neonatal screening for congenital hypothyroidism (CH), Korada et al. (bmj.com)
OBJECTIVE: The aim was to formulate practice guidelines for the diagnosis and management of congenital hypothyroidism (CH). EVIDENCE: A systematic literature search was conducted to identify key articles relating to the screening, diagnosis, and management of CH. The evidence-based guidelines were deve. (bvsalud.org)

So when thyroid hormone levels are low (as in hypothyroidism), the pituitary gland responds by increasing TSH levels. (verywellhealth.com)
The pituitary gland may no longer be able to communicate correctly with the thyroid gland if it is damaged by a tumor, radiation, or surgery, possibly leading to hypothyroidism. (palomahealth.com)
Pituitary harm: One issue your medical doctor could evaluate when posing the question, what exactly is hypothyroidism, is whether the pituitary gland is operating appropriately. (yourfirsthealthcare.com)
Should the pituitary gland malfunctions it will lead to hypothyroidism. (yourfirsthealthcare.com)
Hormone deficiencies such as low levels of thyroid hormone (hypothyroidism) or pituitary gland hormones (hypopituitarism) can trigger jaundice. (findmeacure.com)

Although a shortage of thyroid hormones can cause intellectual disability and other neurological problems, it is unclear whether such issues in individuals with brain-lung-thyroid syndrome are due to hypothyroidism or to the brain abnormalities related to the condition. (medlineplus.gov)
Recommendations for follow-up of infants with laboratory evidence of congenital Zika virus infection depend on whether abnormalities consistent with congenital Zika syndrome are present. (cdc.gov)
A wide range of neurologic abnormalities, in addition to microcephaly, has been observed among infants with presumed or confirmed congenital Zika virus infection ( 2 , 4 ). (cdc.gov)
The most frequent general DS problem is mental retardation associated with a high incidence of congenital heart disease and abnormalities of the gastrointestinal tract. (bvsalud.org)

The recommended starting dose of levothyroxine for congenital hypothyroidism is 10 to 15 μg/kg/day. (medscape.com)
The aim of this study was to investigate the effect of levothyroxine replacement therapy on biomarkers of oxidative stress (OS) and systemic inflammation in patients with hypothyroidism. (medscape.com)
In this prospective open-label study, 17 patients with recently diagnosed primary hypothyroidism due to Hashimoto's thyroiditis who were not taking levothyroxine were included. (medscape.com)
Hypothyroidism is treated with prescription oral thyroid hormone preparation (usually levothyroxine, a T4 preparation). (verywellhealth.com)
Diagnosis and treatment of hypothyroidism in TSH deficiency compared to primary thyroid disease: pituitary patients are at risk of under-replacement with levothyroxine. (nih.gov)
Levothyroxine (LT4) is generally considered to be the treatment of choice for patients with hypothyroidism. (medscape.com)

Many affected individuals have reduced thyroid function from birth ( congenital hypothyroidism ), resulting in lower-than-normal levels of thyroid hormones. (medlineplus.gov)

We determined the prevalence of congenital hypothyroidism and the rate of consanguinity among parents of hypothyroid neonates among 93 381 neonates born in 17 hospitals in Isfahan from May 2002 to April 2005. (who.int)

Objective: The incidence of congenital hypothyroidism (CH) has been shown to vary among different parts of the world. (bgu.ac.il)
In the different origin groups the gender of the parent did not influence significantly the incidence of CH. Conclusions: Environmental changes resulting from immigration can influence the incidence of congenital hypothyroidism. (bgu.ac.il)
to know the incidence of Congenital Hypothyroidism and associated congenital anomalies in this part of the country, which is necessary to understand the burden of congenital hypothyroidism to the society. (paediatricjournal.com)
20mIU/L. Making incidence of Congenital hypothyroidism of 1:737 in our study. (paediatricjournal.com)
In our study we found a higher incidence of 1 in 737, when compared to estimated national incidence of congenital hypothyroidism. (paediatricjournal.com)
While the incidence of true CH is unrelated to gestational age (GA), preterm infants may more often be diagnosed with CH due to physiologic perturbations in thyroid physiology with GA. Given the link between CH and ID, premature infants with suspicion for hypothyroidism are often started on thyroid hormone replacement. (eventscribe.net)

Some common forms of syndromic hypothyroidism include Pendred syndrome , Bamforth-Lazarus syndrome, and brain-lung-thyroid syndrome . (medlineplus.gov)
Why don't we hear much about children who are living with chronic conditions such as Asthma, Autism, Diabetes, Down syndrome, Congenital Heart Disease, Hypothyroidism, hearing loss and visual impairment in resource-poor countries from world leaders and policy makers? (clanchildhealth.org)
Laboratory testing is recommended for 1) infants born to mothers with laboratory evidence of Zika virus infection during pregnancy and 2) infants who have abnormal clinical or neuroimaging findings suggestive of congenital Zika syndrome and a maternal epidemiologic link suggesting possible transmission, regardless of maternal Zika virus test results. (cdc.gov)
Congenital Zika syndrome is a recently recognized pattern of congenital anomalies associated with Zika virus infection during pregnancy that includes microcephaly, intracranial calcifications or other brain anomalies, or eye anomalies, among others ( 2 ). (cdc.gov)

From the perspective of this study, a confirmed case is defined as an abnormal newborn screen (elevated TSH) as well as a clinical diagnosis of congenital hypothyroidism. (cdc.gov)
Results: 48 patients performed clinical reassessment: 10 had overt hypothyroidism (20.8%), 20 showed hyperthyrotropinemia (41.7%) and 18 were euthyroid (37.5%) after L-T4 withdrawal for 4 weeks. (endocrine-abstracts.org)
animals born to females on iodine-deficient diets are more likely to develop severe thyroid enlargement and have clinical signs of hypothyroidism. (merckvetmanual.com)
Clinical manifestations of hypothyroidism are highly variable depending upon etiology, duration, age and severity. (annalskemu.org)
Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. (medscape.com)

The cause of the most common type of congenital hypothyroidism, thyroid dysgenesis, is usually unknown. (medlineplus.gov)

Autoimmune Hashimoto's disease is the most common cause of hypothyroidism. (verywellhealth.com)

Hypothyroidism (or underactive thyroid ) is when the thyroid gland doesn't make enough of some important hormones. (kidshealth.org)
Thyroid hormone replacement with a prescription thyroid drug is the standard treatment for hypothyroidism (low thyroid hormones) caused by an underactive thyroid gland, surgically removed gland, or congenitally damaged or missing gland. (verywellhealth.com)

Hypothyroidism caused by too much iodine may be more common in infants born with heart disease than previously thought. (childrenshospital.org)
DS patients may also exhibit congenital heart disease between 40 and 50% of the cases an increased risk for developing Alzheimer's disease, acute megakaryocytic leukemia, Hirschsprung's disease and duodenal atresia. (bvsalud.org)

Who is at risk for hypothyroidism? (ahealthyme.com)
Young men with hidradenitis suppurativa are "surprisingly" at increased risk for hypothyroidism, Anna Figueiredo, MD, declared at the virtual annual meeting of the American Academy of Dermatology. (medscape.com)
The surprise about this finding from a large retrospective case-control study stems from the fact that the elevated risk for hypothyroidism didn't also extend to younger women with hidradenitis suppurativa (HS) nor to patients older than 40 years of either gender, explained Dr. Figueiredo of the department of dermatology at Northwestern University, Chicago. (medscape.com)

Signs of hypothyroidism (e.g. coarse facies, hoarse cry, umbilical hernia). (scot.nhs.uk)

Those patients were at 3.95-fold greater risk for having a diagnosis of hypothyroidism than were age-matched younger male dermatology patients. (medscape.com)
The diagnosis of hypothyroidism will frequently contain a lot of exams. (yourfirsthealthcare.com)

It's very important to diagnose and treat hypothyroidism right away. (kidshealth.org)

There are several specific inflammatory and oxidative correlates among patients with hypothyroidism, but most studies are cross-sectional and do not evaluate the change in parameters during the treatment. (medscape.com)
Evaluating a patient for congenital hypothyroidism (CH) With rare exceptions, the majority of patients with congenital hypothyroidism will be diagnosed based on an abnormal newborn screen. (cancertherapyadvisor.com)
Liothyronine may improve thyroid function tests in certain patients with congenital hypothyroidism. (childrenshospital.org)
These patients may lose part or all of their thyroid function, causing hypothyroidism. (palomahealth.com)
These drugs may trigger hypothyroidism in patients with a genetic predisposition to autoimmune thyroid disease. (palomahealth.com)
In an age-matched comparison with the dermatology patients without HS, the younger HS cohort was at a significant 1.52-fold increased risk for comorbid hypothyroidism. (medscape.com)
For this study, hypothyroidism patients were given CJC 1295 with no DAC to investigate this connection [5] . (pharmalabglobal.com)

The hypothyroidism status (i.e., overt or subclinical hypothyroidism) was included as a confounder in all analyses. (medscape.com)
Others have a milder condition called compensated or subclinical hypothyroidism, in which thyroid hormone levels are within the normal range, even though the thyroid is not functioning properly. (medlineplus.gov)

A 25+1 week gestational age infant was noted to have Thyroid Stimulating Hormone (TSH) elevation on newborn screen consistent with hypothyroidism. (eventscribe.net)

Additionally, CH with certain genetic aetiologies ( NIS , IYD , DUOX2 mutations) may present with normal neonatal TSH levels but evolve to significant hypothyroidism in later childhood. (endocrinology.org)
Proceedings of "Reunion Europeene sur le Depistage Neonatal en 1986. (bmj.com)

People with congenital hypothyroidism have lower-than-normal levels of these important hormones. (medlineplus.gov)
The resulting shortage of thyroid hormones disrupts normal growth, brain development, and metabolism, leading to the features of congenital hypothyroidism. (medlineplus.gov)

Hypothyroidism is a common condition, especially in adult women. (kidshealth.org)
Congenital hypothyroidism (CH) is a well-known condition occurring in approximately 1:2,000 infants and is the most common cause of preventable intellectual disability (ID) worldwide. (eventscribe.net)
ND tube feeds and hypothyroidism necessitating thyroid replacement are common occurrences in the preterm neonate population. (eventscribe.net)
Hypothyroidism is the most common type of thyroid disorder. (ahealthyme.com)
Learn how hypothyroidism, the most common thyroid disease, can affect testosterone levels. (palomahealth.com)
Hypothyroidism is the most common thyroid disorder in babies, children and teenagers. (bluecrestwellness.com)
Autoimmune hypothyroidism often appears during the teenage years, and it's more common in girls than boys. (bluecrestwellness.com)

Congenital hypothyroidism (CH) is the most preventable cause of mental retardation (3). (bvsalud.org)

When congenital hypothyroidism results from mutations in the PAX8 gene or from certain mutations in the TSHR or DUOX2 gene, the condition has an autosomal dominant pattern of inheritance, which means one copy of the altered gene in each cell is sufficient to cause the disorder. (medlineplus.gov)
Congenital hypothyroidism is a pediatric disorder with an observed prevalence in the United States of one in 2,000-4,000 live births ( 3 ) and a prevalence in Utah of one in 2,800. (cdc.gov)
Congenital hypothyroidism is a metabolic disorder that requires special health care interventions. (bvsalud.org)

Total T4 assays measure T4 in both states and are useful to establish the diagnosis of primary hypothyroidism and to assess the response to treatment. (medscape.com)
In congenital hypothyroidism, treatment should be started as soon as the diagnosis is suggested, preferably before 2 weeks of life. (medscape.com)
Not indicated for treatment of hypothyroidism during the recovery phase of subacute thyroiditis. (nih.gov)
Prior to the widespread availability of the current gold standard hypothyroidism treatment of LT4, the condition was typically treated with desiccated (animal) thyroid extract. (medscape.com)
A New Treatment Alternative for Congenital Hypothyroidism. (eventscribe.net)
The aim of this paper is to report the dental treatment of a child with congenital hypothyroidism who is four years and five months old, with many facial and oral characteristics of the metabolic condition, including severe early childhood caries and malocclusion. (bvsalud.org)

When hypothyroidism is adequately treated, TSH levels typically drop back down into the normal range. (verywellhealth.com)

Affected babies may show no features of the condition, although some babies with congenital hypothyroidism are less active and sleep more than normal. (medlineplus.gov)
Isolated congenital hypothyroidism (CH) is a condition occurring at or near birth characterized by insufficient thyroid hormone production. (pwdfoundation.org)
children had a known underlying condition: congenital hypothyroidism (n = 1) and HIV infection (n = 1). (cdc.gov)
A condition called secondary hypothyroidism can also sometimes happen. (ahealthyme.com)
This condition is called congenital hypothyroidism. (ahealthyme.com)
Congenital hypothyroidism: Being born While using the condition of hypothyroidism is another way to answer the issue, precisely what is hypothyroidism. (yourfirsthealthcare.com)

Congenital hypothyroidism is a partial or complete loss of function of the thyroid gland (hypothyroidism) that affects infants from birth (congenital). (medlineplus.gov)
For reasons that remain unclear, congenital hypothyroidism affects more than twice as many females as males. (medlineplus.gov)
Congenital hypothyroidism affects a ratio of 1 in 4000 newborn babies and used to be a major cause of mental disabilities. (thyroid.ca)

Congenital hypothyroidism can be caused by a variety of factors, only some of which are genetic. (medlineplus.gov)

Blood tests can also help diagnose hypothyroidism. (ahealthyme.com)
immediately after managing the required checks, your health care provider will be able to diagnose and take care of your hypothyroidism. (yourfirsthealthcare.com)

Anatomy3

Diseases8

Chemicals and Drugs13

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Psychiatry and Psychology1

Technology, Industry, Agriculture1

Named Groups1

Health Care2

Pertechnetate scintigraphy in primary congenital hypothyroidism. (1/303)

Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism. (2/303)

Early cellular abnormalities induced by RET/PTC1 oncogene in thyroid-targeted transgenic mice. (3/303)

Intellectual outcome at 12 years of age in congenital hypothyroidism. (4/303)

Iodine and neuropsychological development. (5/303)

Thyroid stimulating hormone levels in cord blood are not influenced by non-thyroidal mothers' diseases. (6/303)

Novel mutations of the thyroid peroxidase gene in patients with permanent congenital hypothyroidism. (7/303)

Longitudinal growth, sexual maturation and final height in patients with congenital hypothyroidism detected by neonatal screening. (8/303)

Congenital Hypothyroidism

Hypothyroidism

Thyroid Dysgenesis

Neonatal Screening

Thyroxine

Thyrotropin

Thyroid Function Tests

Thyroid Gland

Thyroid Hormones

Infant, Newborn

Goiter

Thyroglobulin

Triiodothyronine

Thyroid (USP)

Iodide Peroxidase

Iodine

Insurance Carriers

Sodium Pertechnetate Tc 99m

Soy Milk

Receptors, Thyrotropin

Cranial Fontanelles

Phenylketonurias

Thyroxine-Binding Proteins

Methimazole

Iodides

Natal Teeth

Macroglossia

Fluoroimmunoassay

Hyperthyroidism

Intelligence

Choristoma

Pertechnetate scintigraphy in primary congenital hypothyroidism. (1/303)

Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism. (2/303)

Early cellular abnormalities induced by RET/PTC1 oncogene in thyroid-targeted transgenic mice. (3/303)

Intellectual outcome at 12 years of age in congenital hypothyroidism. (4/303)

Iodine and neuropsychological development. (5/303)

Thyroid stimulating hormone levels in cord blood are not influenced by non-thyroidal mothers' diseases. (6/303)

Novel mutations of the thyroid peroxidase gene in patients with permanent congenital hypothyroidism. (7/303)

Longitudinal growth, sexual maturation and final height in patients with congenital hypothyroidism detected by neonatal screening. (8/303)

Identification of Primary Congenital Hypothyroidism Based on Two Newborn Screens - Utah, 2010-2016

Congenital hypothyroidism due to a new deletion in the sodium/iodide symporter protein<...

Term Neonate with Respiratory Distress Syndrome Secondary to Congenital Hypothyroidism | International Journal of...

Australian Thyroid Foundation - Congenital Hypothyroidism

A frequent oligogenic involvement in congenital hypothyroidism<...

Permanent and Transient Congenital Hypothyroidism in Fayoum, Egypt: A Descriptive Retrospective Study

The clinical and molecular characterization of patients with dyshormonogenic congenital hypothyroidism reveals specific...

International Journal of Endocrinology and Metabolism - Permanent and Transient Congenital Hypothyroidism in Hamadan West...

Sabinet | Anaesthetic considerations in a prematurely born infant with congenital hypothyroidism presenting for cataract...

UNTHSC Scholarly Repository - Research Appreciation Day: Congenital Hypothyroidism

The Italian National Register of infants with congenital hypothyroidism: twenty years of surveillance and study of congenital...

Congenital Hypothyroidism and Blood Draws and Courage<...

Congenital Hypothyroidism in Children - Know Your Thryoid

Congenital Hypothyroidism

Congenital hypothyroidism from complete iodide transport defect: long-term evolution with iodide treatment. | Postgraduate...

Hypothyroidism caused by the combination of two heterozygous mutations: one in the TSH receptor gene the other in the DUOX2...

Children with congenital hypothyroidism: long-term intellectual outcome after early high-dose treatment - Zurich Open...

Congenital Hypothyroidism in Children | Phoenix Childrens Hospital

Congenital Hypothyroidism in Children

Congenital Hypothyroidism in Children

Congenital Hypothyroidism in Children

Congenital Hypothyroidism in Children

Congenital Hypothyroidism in Children

Neonatal plasma TSH - estimated upper reference intervals for diagnosis and follow up of congenital hypothyroidism -ORCA

Congenital Hypothyroidism: Neonatal SCREENING PROGRAM with T4 and TSH | ESPE2019

Congenital Hypothyroidism Differential Diagnoses

Most recent papers with the keyword Congenital hypothyroidism | Read by QxMD

Zebrafish duox mutations provide a model for human congenital hypothyroidism | Biology Open

Elevated Hormone Levels, Congenital Hypothyroidism, Psychiatric Problem

Usefulness of Ultrasonography in The Diagnosis of The Etiology of Congenital Hypothyroidism Comparing with Radioisotope...

Congenital hypothyroidism with goiter in toy fox terriers | Advanced Veterinary Medical Imaging

Neonatal screening for congenital hypothyroidism in the Netherlands: cognitive and motor outcome at 10 years of age.

How Do I Treat Congenital Hypothyroidism? | PediatricEducation.org™

Congenital hypothyroidism: follow up of a case for 13 years | Abstract

Congenital Hypothyroidism in Children Confers Neurocognitive Impairment Risk - Endocrinology Advisor

Auditory Brainstem Evoked Potentials in Congenital Hypothyroidism Screening Program Graduates for Abd Allah Loai Mostafa Ahmed

Suffers congenital hypothyroidism, on Thyronorm. Irregular bowels, tried glycerine suppository. How to cure constipation ? -...

Expressing the quantity variants of fibroblast growth factors-21 (FGF-21) in mice with congenital hypothyroidism

Congenital Hypothyroidism | Atlanta Outpatient Surgery Center

Congenital Hypothyroidism of Dogs and Cats: A Review | Advanced Veterinary Medical Imaging

Congenital Hypothyroidism May Reduce Hippocampus Activation in Verbal Memory Processing - Endocrinology Advisor