Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Elements of limited time intervals, contributing to particular results or situations.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
An infant during the first month after birth.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The period of confinement of a patient to a hospital or other health facility.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
The return of a sign, symptom, or disease after a remission.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Hospitals maintained by a university for the teaching of medical students, postgraduate training programs, and clinical research.
The former British crown colony located off the southeast coast of China, comprised of Hong Kong Island, Kowloon Peninsula, and New Territories. The three sites were ceded to the British by the Chinese respectively in 1841, 1860, and 1898. Hong Kong reverted to China in July 1997. The name represents the Cantonese pronunciation of the Chinese xianggang, fragrant port, from xiang, perfume and gang, port or harbor, with reference to its currents sweetened by fresh water from a river west of it.
A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
The confinement of a patient in a hospital.
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
A medical facility which provides a high degree of subspecialty expertise for patients from centers where they received SECONDARY CARE.
A country in western Europe bordered by the Atlantic Ocean, the English Channel, the Mediterranean Sea, and the countries of Belgium, Germany, Italy, Spain, Switzerland, the principalities of Andorra and Monaco, and by the duchy of Luxembourg. Its capital is Paris.
Recording of pertinent information concerning patient's illness or illnesses.
The frequency of different ages or age groups in a given population. The distribution may refer to either how many or what proportion of the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine.
Hospitals engaged in educational and research programs, as well as providing medical care to the patients.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
The presence of co-existing or additional diseases with reference to an initial diagnosis or with reference to the index condition that is the subject of study. Comorbidity may affect the ability of affected individuals to function and also their survival; it may be used as a prognostic indicator for length of hospital stay, cost factors, and outcome or survival.
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Substances that reduce the growth or reproduction of BACTERIA.
A vital statistic measuring or recording the rate of death from any cause in hospitalized populations.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
The number of males and females in a given population. The distribution may refer to how many men or women or what proportion of either in the group. The population is usually patients with a specific disease but the concept is not restricted to humans and is not restricted to medicine.
A detailed review and evaluation of selected clinical records by qualified professional personnel for evaluating quality of medical care.
Disease having a short and relatively severe course.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
The use of internal devices (metal plates, nails, rods, etc.) to hold the position of a fracture in proper alignment.
Hospital units providing continuous surveillance and care to acutely ill patients.
A parliamentary democracy with a constitutional monarch in southeast Asia, consisting of 11 states (West Malaysia) on the Malay Peninsula and two states (East Malaysia) on the island of BORNEO. It is also called the Federation of Malaysia. Its capital is Kuala Lumpur. Before 1963 it was the Union of Malaya. It reorganized in 1948 as the Federation of Malaya, becoming independent from British Malaya in 1957 and becoming Malaysia in 1963 as a federation of Malaya, Sabah, Sarawak, and Singapore (which seceded in 1965). The form Malay- probably derives from the Tamil malay, mountain, with reference to its geography. (From Webster's New Geographical Dictionary, 1988, p715 & Room, Brewer's Dictionary of Names, 1992, p329)
A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja.
Complications that affect patients during surgery. They may or may not be associated with the disease for which the surgery is done, or within the same surgical procedure.
A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A country in northern Africa between ALGERIA and LIBYA. Its capital is Tunis.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Tumors or cancer of the human BREAST.
A measure of the quality of health care by assessment of unsuccessful results of management and procedures used in combating disease, in individual cases or series.
Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Clarity or sharpness of OCULAR VISION or the ability of the eye to see fine details. Visual acuity depends on the functions of RETINA, neuronal transmission, and the interpretative ability of the brain. Normal visual acuity is expressed as 20/20 indicating that one can see at 20 feet what should normally be seen at that distance. Visual acuity can also be influenced by brightness, color, and contrast.
Therapy with two or more separate preparations given for a combined effect.
Hospital department responsible for the administration and provision of immediate medical or surgical care to the emergency patient.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Incorrect diagnoses after clinical examination or technical diagnostic procedures.
Fractures of the upper jaw.
Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.
A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.
The period following a surgical operation.
Tumors or cancer of the LUNG.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The presence of viable bacteria circulating in the blood. Fever, chills, tachycardia, and tachypnea are common acute manifestations of bacteremia. The majority of cases are seen in already hospitalized patients, most of whom have underlying diseases or procedures which render their bloodstreams susceptible to invasion.
Systems for assessing, classifying, and coding injuries. These systems are used in medical records, surveillance systems, and state and national registries to aid in the collection and reporting of trauma.
Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.
An anatomic severity scale based on the Abbreviated Injury Scale (AIS) and developed specifically to score multiple traumatic injuries. It has been used as a predictor of mortality.
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
The practice of sending a patient to another program or practitioner for services or advice which the referring source is not prepared to provide.
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
Large hospitals with a resident medical staff which provides continuous care to maternity, surgical and medical patients.
Infection occurring at the site of a surgical incision.
Procedures used to treat and correct deformities, diseases, and injuries to the MUSCULOSKELETAL SYSTEM, its articulations, and associated structures.
A surgical operation for the relief of pressure in a body compartment or on a body part. (From Dorland, 28th ed)
Situations or conditions requiring immediate intervention to avoid serious adverse results.
Fractures of the zygoma.
The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.
A country spanning from central Asia to the Pacific Ocean.
Advanced and highly specialized care provided to medical or surgical patients whose conditions are life-threatening and require comprehensive care and constant monitoring. It is usually administered in specially equipped units of a health care facility.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Multiple physical insults or injuries occurring simultaneously.
Procedures used to reconstruct, restore, or improve defective, damaged, or missing structures.
A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.
Surgical procedures used to treat disease, injuries, and defects of the oral and maxillofacial region.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Research techniques that focus on study designs and data gathering methods in human and animal populations.
The ratio of the number of conceptions (CONCEPTION) including LIVE BIRTH; STILLBIRTH; and fetal losses, to the mean number of females of reproductive age in a population during a set time period.
The visualization of tissues during pregnancy through recording of the echoes of ultrasonic waves directed into the body. The procedure may be applied with reference to the mother or the fetus and with reference to organs or the detection of maternal or fetal disease.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
Special hospitals which provide care for ill children.
Specialized devices used in ORTHOPEDIC SURGERY to repair bone fractures.
The process of accepting patients. The concept includes patients accepted for medical and nursing care in a hospital or other health care institution.
Operative immobilization or ankylosis of two or more vertebrae by fusion of the vertebral bodies with a short bone graft or often with diskectomy or laminectomy. (From Blauvelt & Nelson, A Manual of Orthopaedic Terminology, 5th ed, p236; Dorland, 28th ed)
Surgical incision of the trachea.
The transference of a kidney from one human or animal to another.
Factors which produce cessation of all vital bodily functions. They can be analyzed from an epidemiologic viewpoint.
Divisions of the year according to some regularly recurrent phenomena usually astronomical or climatic. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A malignant epithelial tumor with a glandular organization.
The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)
An appreciable lateral deviation in the normally straight vertical line of the spine. (Dorland, 27th ed)
Tumors or cancer of the LIVER.
Surgery performed on the nervous system or its parts.
The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)
Hemorrhage following any surgical procedure. It may be immediate or delayed and is not restricted to the surgical wound.
One of a pair of irregularly shaped bones that form the upper jaw. A maxillary bone provides tooth sockets for the superior teeth, forms part of the ORBIT, and contains the MAXILLARY SINUS.
First aid or other immediate intervention for accidents or medical conditions requiring immediate care and treatment before definitive medical and surgical management can be procured.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
Diseases of domestic and wild horses of the species Equus caballus.
The plan and delineation of prostheses in general or a specific prosthesis.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
The excision of lung tissue including partial or total lung lobectomy.
The transference of a part of or an entire liver from one human or animal to another.
An assisted reproductive technique that includes the direct handling and manipulation of oocytes and sperm to achieve fertilization in vitro.
The proportion of patients with a particular disease during a given year per given unit of population.
The probability that an event will occur. It encompasses a variety of measures of the probability of a generally unfavorable outcome.
The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Persons admitted to health facilities which provide board and room, for the purpose of observation, care, diagnosis or treatment.
A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)
Incision into the side of the abdomen between the ribs and pelvis.
Deeply perforating or puncturing type intraocular injuries.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
VERTEBRAE in the region of the lower BACK below the THORACIC VERTEBRAE and above the SACRAL VERTEBRAE.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.
A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.
The study of chance processes or the relative frequency characterizing a chance process.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Institutions with an organized medical staff which provide medical care to patients.
Tongues of skin and subcutaneous tissue, sometimes including muscle, cut away from the underlying parts but often still attached at one end. They retain their own microvasculature which is also transferred to the new site. They are often used in plastic surgery for filling a defect in a neighboring region.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).
Saccular lesions lined with epithelium and contained within pathologically formed cavities in the jaw; also nonepithelial cysts (pseudocysts) as they apply to the jaw, e.g., traumatic or solitary cyst, static bone cavity, and aneurysmal bone cyst. True jaw cysts are classified as odontogenic or nonodontogenic.
The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.
The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.
Malformations of organs or body parts during development in utero.
Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)
The capital is Seoul. The country, established September 9, 1948, is located on the southern part of the Korean Peninsula. Its northern border is shared with the Democratic People's Republic of Korea.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The surgical cutting of a bone. (Dorland, 28th ed)
Inanimate objects that become enclosed in the body.
The period of care beginning when the patient is removed from surgery and aimed at meeting the patient's psychological and physical needs directly after surgery. (From Dictionary of Health Services Management, 2d ed)
Postmortem examination of the body.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
The period before a surgical operation.
Diseases of the domestic cat (Felis catus or F. domesticus). This term does not include diseases of the so-called big cats such as CHEETAHS; LIONS; tigers, cougars, panthers, leopards, and other Felidae for which the heading CARNIVORA is used.
The physiological restoration of bone tissue and function after a fracture. It includes BONY CALLUS formation and normal replacement of bone tissue.
The transfer of mammalian embryos from an in vivo or in vitro environment to a suitable host to improve pregnancy or gestational outcome in human or animal. In human fertility treatment programs, preimplantation embryos ranging from the 4-cell stage to the blastocyst stage are transferred to the uterine cavity between 3-5 days after FERTILIZATION IN VITRO.
Breaks in bones.
Surgery performed on the ear and its parts, the nose and nasal cavity, or the throat, including surgery of the adenoids, tonsils, pharynx, and trachea.
Medical complexes consisting of medical school, hospitals, clinics, libraries, administrative facilities, etc.
Injuries involving the vertebral column.
The practice of replacing one prescribed drug with another that is expected to have the same clinical or psychological effect.
The first seven VERTEBRAE of the SPINAL COLUMN, which correspond to the VERTEBRAE of the NECK.
Parliamentary democracy located between France on the northeast and Portugual on the west and bordered by the Atlantic Ocean and the Mediterranean Sea.
Hospitals which provide care for a single category of illness with facilities and staff directed toward a specific service.
Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.
Excision of the uterus.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
... a retrospective study of 231 confirmed cases (2000-2010)". Journal of Feline Medicine and Surgery. 18 (4): 348-356. doi:10.1177 ... Clinical signs: the cat has become anorexic or is eating less than usual; has lost weight or failed to gain weight; has a fever ... The hallmark clinical sign of effusive FIP is the accumulation of fluid within the abdomen or chest, which can cause breathing ... In a study which compared various commercially available in-house FCoV antibody tests, the FCoV Immunocomb (Biogal) was 100% ...
Prospective clinical trials are needed to confirm this finding, but in vitro data support the supposition that this combination ... The optimal treatment is not known, but in one retrospective study of 93 people in Taiwan, use of a third-generation ... While the VvhA and MARTX toxin are factors in the bacteria's virulence, in vivo studies in mice suggest that the MARTX toxin is ... Reichelt JL, Baumann P, Baumann L (October 1976). "Study of genetic relationships among marine species of the genera Beneckea ...
... studies using existing data and prospective blinded clinical studies on new patients. In retrospective CAA studies, a ... "The true performance of a selected network (CAA system) should be confirmed by measuring its performance on a third independent ... provided that the study is blinded and well controlled). In a prospective clinical study to evaluate the performance of a CAA ... non-blinded studies are usually considered to be much lower than that of prospective clinical studies because they are prone to ...
Additional studies are necessary to confirm the findings of a retrospective study of 154 patients with MPP that associated the ... Multiple studies have also reported an association of HLA-DQB1*0301 with MPP. Diagnosis of bullous pemphigoid includes clinical ... April 1996). "Treatment of bullous pemphigoid with dapsone: retrospective study of thirty-six cases". Journal of the American ... According to the results of several retrospective studies, there is an increasing incidence of bullous pemphigoid. Bullous ...
A 2019 retrospective study evaluated Ada DX potential impact in accelerating rare disease diagnosis with the following results ... More than 33% of patients could have been identified as having a rare disease in the first documented clinical visit. In 2020, ... Ada's top suggestion matched the confirmed diagnosis in 89.25% of cases (83 of 93 cases). In more than 56% of cases, Ada ... provided correct disease suggestions earlier than the time of clinical diagnosis. ...
The optimal treatment is not known, but in one retrospective study of 93 people in Taiwan, use of a third-generation ... Prospective clinical trials are needed to confirm this finding, but in vitro data support the supposition that this combination ... James, William D.; Berger, Timothy G. (2006). Andrews' Diseases of the Skin: Clinical Dermatology. Saunders Elsevier. ISBN 0- ... Reichelt JL, Baumann P, Baumann L (October 1976). "Study of genetic relationships among marine species of the genera Beneckea ...
The first study was a retrospective study of sex offenders, which included only those subjects whose clinical charts happened ... Multiple studies have since confirmed this finding. In a few studies, homosexual subjects have occasionally displayed both a ... meta-analysis of studies by independent investigators and studies by both Blanchard and other investigators shows that studies ... Another study (Blanchard and Bogaert, 1998) did not confirm a later fraternal birth order for men with sexual offenses against ...
20/148 Clinical pregnancy: 4/148 This study considers the effect of FSH levels on clinical success, and it excludes abnormal ... A retrospective analysis performed in 2015 detailed the outcomes of N=148 men with non-obstructive azoospermia and diagnosed ... Testicular biopsy would confirm the absence of spermatozoa. Seminal plasma protein TEX101 was proposed for differentiation of ... A clinical trial at Mount Sinai Hospital, Canada started testing this hypothesis in 2016. Sertoli cell-only syndrome is like ...
Diagnosis requires a high degree of clinical suspicion and can be confirmed with barium contrast esophagogram for those with ... a retrospective study of 62 cases". J. Pediatr. Surg. 38 (4): 539-43. doi:10.1053/jpsu.2003.50117. PMID 12677561.CS1 maint: ...
C. innocuum has also been implicated in cases of fatal bacteremia as reported in a retrospective study done by Newark Beth ... of clinical bacteremia, C innocuum was among the three most commonly isolated bacteria in this study. C. innocuum has also been ... This is possibly the only confirmed case of C. innocuum endocarditis involving the pulmonary and tricuspid valves resulting in ... and Clostridium ramosum compared with those of clinical isolates of Clostridium perfringens". Journal of Clinical Microbiology ...
Additional studies have confirmed its clinical relevance. Molina-Pinelo S, Pastor MD, Paz-Ares L (2014). "VeriStrat: a ... The Lancet Oncology A Retrospective Analysis of VeriStrat Status on Outcome of a Randomized Phase II Trial of First-Line ... such as the PROSE study, confirming the prognostic information associated with the molecular signature. In addition, the test ...
He conducted retrospective analysis of prospectively collected data on traumatic cervical spinal cord injury. These studies ... 2017). "A Clinical Practice Guideline for the Management of Patients With Acute Spinal Cord Injury: Recommendations on the Type ... Efficacy of Ultra-Early (< 12 h), Early (12-24 h), and Late (>24-138.5 h) Surgery with Magnetic Resonance Imaging-Confirmed ... During the decade spanning from 1980 to 1990, he was involved in cohort studies of soldiers and civilians injured in battle in ...
... with some studies showing extremely high male-to-female ratios (12:1 or more). In a study of over 150,000 lung cancer victims ... This clinical characteristic of GCCL has been seen in cases spanning over half a century in time. Within the small bowel, the ... GCCL was first confirmed as an epithelial tumor (and not a dedifferentiated pleomorphic sarcoma) in 1961. In 1964-65, theories ... and all information available derives from small retrospective institutional series or multicenter metadata. Giant-cell lung ...
In a retrospective study noted by Acta Ophthalmologica, spironolactone improved visual acuity in CSR patients over the course ... Follow-up studies have confirmed the treatment's long-term effectiveness including its effectiveness for the chronic variant of ... A clinical record should be taken to keep a timeline of the detachment. An Amsler grid can be useful in documenting the precise ... retrospective studies may erroneously report positive treatment outcomes and should, therefore, be evaluated with caution. Full ...
Confirming the positive finding of another large study,[20] the landmark Women's Health Initiative (WHI) reported very ... A retrospective (historical) cohort study was performed on a very large data base including 1980 and 1981 Medicaid billing data ... Clinical Pharmacology and Therapeutics. 39 (3): 335-41. doi:10.1038/clpt.1986.49. PMID 3948473.. ... A 2001 comparative study of the IMS LifeLink Health Plan Claims Database interpreted that in a large cohort of women using oral ...
A placebo-controlled study of nitazoxanide in cryptosporidiosis demonstrated significant clinical improvement in adults and ... A retrospective review of charts of patients treated with nitazoxanide for trichomoniasis by Michael Dan and Jack D. Sobel ... While confirming the safety of the drug, they showed nitazoxanide is ineffective for the treatment of trichomoniasis. ... Initial studies demonstrated activity versus tapeworms. In vitro studies demonstrated much broader activity. Dr. Rossignol co- ...
The diagnosis of cavernous sinus thrombosis is made clinically, with imaging studies to confirm the clinical impression. ... Retrospective studies show conflicting data. This decision should be made with subspecialty consultation. One systematic review ... diagnosis.Cavernous sinus thrombosis is a clinical diagnosis with laboratory tests and imaging studies confirming the clinical ... The clinical presentation of CST can be varied. Both acute, fulminant disease and indolent, subacute presentations have been ...
In a retrospective cohort of 136 CAPS patients with systemic involvement from 16 countries, the most prevalent clinical ... Previous studies confirm these symptoms, although the exact reported rates vary. Cryopyrin-associated periodic syndromes are ... There are currently no clinical or diagnostic criteria for CAPS based solely on clinical presentation. Instead, diagnosis is ... Kallinich, T.; Hoffman, H. M.; Roth, J.; Keitzer, R. (2016-06-01). "The clinical course of a child with CINCA/NOMID syndrome ...
... nearly all studies have been retrospective, and clinical utility has yet to be established in a large scale prospective ... the identification of microorganisms that have not been identified before in the laboratory should be independently confirmed, ... To date, several studies have provided a glimpse into the promise of NGS in clinical and public health settings. Even though, ... So prospective clinical studies will be critical to understand when to perform mNGS and how the diagnostic yield compares with ...
A retrospective study carried out at an Auckland emergency department found that BZP presentations only made a minor ... Blood benzylpiperazine concentrations have been measured either to confirm clinical intoxication or as part of a medicolegal ... The majority of the toxic effects information came from a study conducted between 1 April 2005 to 1 September 2005. The study ... The study suggested that BZP "should be placed under statutory control similar to those regulating the use of amphetamine". In ...
conducted a retrospective study on persistent infections in pediatric oncology patients and determined human astrovirus to be ... conduct a clinical study in Bangladesh and conclude astrovirus infections involving nosocomial, acute, and persistent diarrheal ... The presence of VA1/HMO-C was confirmed after positive PCR test results. Madeley CR, Cosgrove BP (September 1975). "Letter: 28 ... conducted a clinical study, and 78-year-old male Waldenström's macroglobulinemia patient with astrovirus-associated ...
A small study involving 6 confirmed COVID-19 mothers showed no indication of SARS-CoV-2 in their newborns' throats or serum but ... suggest that pregnant women are at an increased risk of severe infection but findings from studies to date show that clinical ... a retrospective review of medical records". Lancet. 395 (10226): 809-815. doi:10.1016/S0140-6736(20)30360-3. PMC 7159281. PMID ... The UKOSS study found that median gestational age at birth was 38 weeks and that 27% of women studied had preterm births. Of ...
Surveys and retrospective studies of patients with IPF have indicated that there is a significant diagnostic delay, with a ... Diagnostic delay is the time interval between the onset of symptoms and confirmed diagnosis of a disease. For a variety of ... This delay was attributed to the absence of major pulmonary embolism risk factors, or clinical presentations like chest pain, ... A 2017 study of TB in India . A 2018 study in Zanzibar on a different form of TB, extrapulmonary tuberculosis, found many ...
A 1999 retrospective study of 74 cases of neonatal onset found that 32 (43%) patients died during their first hyperammonemic ... In cases where prenatal diagnosis was requested, a fetal liver biopsy used to be required to confirm if a fetus was affected. ... Even for patients with late onset forms of the disease, their overall clinical picture is dependent on the extent of ... Early estimates of the incidence were as high as 1:14,000 live births, however later studies have decreased these estimates to ...
Feminization is confirmed with the finding of excess serum estrogen.[citation needed] Radiological studies of the abdomen, such ... Allolio B, Fassnacht M (June 2006). "Clinical review: Adrenocortical carcinoma: clinical update". The Journal of Clinical ... A retrospective analysis showed a survival benefit for mitotane in addition to surgery when compared to surgery alone. The two ... Adrenal virilism is confirmed by the finding of an excess of serum androstenedione and dehydroepiandrosterone. Findings in Conn ...
The retrospective "miss" rate among abnormal imaging studies is reported to be as high as 30% (the real-life error rate is much ... Pat Croskerry describes clinical reasoning as an interplay between intuitive, subconscious thought (System 1) and deliberate, ... to confirm the correct diagnosis. Many diagnostic errors fit several of these criteria; the categories overlap. There are two ... One study suggests that adults in the United States receive only 55% of recommended care. At the same time, a second study ...
A nationwide matched retrospective cohort study' in 'PLOS ONE', an international journal equivalent to SCI (2018) Published ... It is the first paper to confirm the effects of acupuncture on acute low back pain (2012) The cartilage regeneration effects of ... Proved clinical effects of Integrative Korean Medicine Treatment for patients with Failed Back Surgery Syndrome - published in ... A nationwide matched retrospective cohort study". PLOS ONE. 13 (6): e0199042. Bibcode:2018PLoSO..1399042K. doi:10.1371/journal. ...
This offers a dual approach to both seeing trends in retrospective studies and using biomarkers to predict outcomes. For ... clinical validation study (DETECT AF PRO)". Europace. 21 (1): 41-47. doi:10.1093/europace/euy176. PMC 6321964. PMID 30085018. ... Simultaneously, it is possible to confirm the relevance of the protocol with various methods (histology, PCR, ELISA, ...) and ... In this case, the lack of data beyond retrospective studies and successful biomarker-driven approaches was suggested to be ...
... clinical validation study (DETECT AF PRO)". Europace. 21 (1): 41-47. doi:10.1093/europace/euy176. PMC 6321964. PMID 30085018.. ... This offers a dual approach to both seeing trends in retrospective studies and using biomarkers to predict outcomes. For ... Simultaneously, it is possible to confirm the relevance of the protocol with various methods (histology, PCR, ELISA, ...) and ... Ecotoxicologial studies could be considered the precursors to biomarker studies.[22] Biomarkers are used to indicate an ...
Sections on clinical studies, case studies, and naming of Copenhagen disease. Individuals with Copenhagen disease are often ... Retrospective Analysis of 10 Individuals with Copenhagen Disease A retrospective study was conducted to better understand the ... MRI scans (favored) and X-rays are used to confirm a diagnosis of PAVF when radiological features are present. MRI is used to ... The study followed up with the individuals in about 14.7 years (mean). Health-related quality of life (HRQOL) was measured ...
... a meta-analysis of prospective cohort studies". Diabetes Research and Clinical Practice. 89 (3): 309-19. doi:10.1016/j.diabres. ... a meta-analysis of retrospective cohort studies". Chinese Medical Journal. 125 (23): 4301-6. PMID 23217404.. ... diagnosis is in doubt antibody testing may be useful to confirm type 1 diabetes and C-peptide levels may be useful to confirm ... "The Journal of Clinical Endocrinology and Metabolism. 99 (10): 3551-60. doi:10.1210/jc.2014-2136. PMC 4483466. PMID 25062463.. ...
Clinical observations[edit]. A study involving 2408 donors (18-60 years) indicated that bone pain (primarily back and hips) as ... "One million haemopoietic stem-cell transplants: a retrospective observational study". Lancet Haematol. 2015 Mar 2(3): e91-100. ... he discovered genetic markers that could confirm donor matches. ... A study that surveyed 2408 donors found that serious adverse ... 2008). "Clinical applications of blood-derived and marrow-derived stem cells for nonmalignant diseases". JAMA. 299 (8): 925-36 ...
Dymond NL, Swift IM (June 2008). "Permethrin toxicity in cats: a retrospective study of 20 cases". Aust Vet J. 86 (6): 219-23. ... "European Journal of Clinical Chemistry and Clinical Biochemistry (Submitted manuscript). 32 (9): 685-9. doi:10.1515/cclm. ... This is also confirmed by the writings of Peter Kalm, a Swedish botanist who was sent to America by Linnaeus, and who found the ... The early European studies of what is now known as Lyme disease described its skin manifestations. The first study dates to ...
"Experimental and Clinical Studies on Rifampicin in Treatment of Leprosy". Br Med J. 688 (1): 89-92. doi:10.1136/bmj.1.5688.89. ... This confirmed the spread of the disease along the migration, colonisation, and slave trade routes taken from East Africa to ... Scholars acknowledge that it is difficult to make retrospective diagnoses of leprosy from symptoms described in ancient ... Study and analysis of these remains were documented as the oldest skeletal evidence for leprosy. The scholars who studied these ...
After studying them for a triumphal[A] retrospective paper on Gage,[6] Harlow redeposited the iron-this time with Gage's skull- ... used CT scans of Gage's actual skull[20][21] to confirm Harlow's conclusion (based on probing Gage's wounds with his finger)[18 ... Journal of Consulting and Clinical Psychology. 60 (3): 349-359. doi:10.1037/0022-006X.60.3.349. PMID 1619089.. ... was the first study to account for the hairline fracture running from behind the exit region down the front of Gage's skull, as ...
A Retrospective Cohort Study of Efficacy and Safety". Journal of Ultrasound in Medicine. 33 (2): 337-341. doi:10.7863/ultra. ... "Clinical Guidelines: Induction of fetal demise before abortion" (PDF). Contraception: a publication of Society of Family ... or confirmed voluntary muscle movement, regardless of gestational age.[137][138] To ensure the success of the abortion ... A1998 study revealed that in 1987 to 1988, women reported the following as their primary reasons for choosing an abortion:[88][ ...
No pre-research literature review. Studying the literature of the area under study gives preconceptions about what to find and ... The constant comparative method comes into play, along with negative case analysis which looks for cases that do not confirm ... as juxtaposed with purposeful discovery by experiment or retrospective prophecy). ... "Clinical Nursing Research: 1054773816630535. doi:10.1177/1054773816630535. ISSN 1054-7738. PMID 26858262.. ...
Newer research approaches are currently being studied, including preclinical and clinical investigations into the use of an ... a retrospective, cohort-based study". The Lancet. Oncology. 18 (2): 202-211. doi:10.1016/S1470-2045(16)30648-9. PMID 27993569. ... An association was confirmed between total cellular manganese contents and their variation, and clinically-inferred ... Studies found, for example, that the IQ of 5 year old children declined each year after treatment by several IQ points.[21]. ...
... whose work Virchow studied, and that of Paul Ehrlich, who studied at the Charité while Virchow was developing microscopic ... "Clinical Medicine & Research. 8 (3-4): 168-172. doi:10.3121/cmr.2009.866. PMC 3006583. PMID 20739582.. ... He confirmed through microscopic observation that the white particles were indeed the larvae of roundworms, curled up in the ... Lopes, Ademar; Rossi, Benedito Mauro; Silveira, Claudio Regis Sampaio; Alves, Antonio Correa (1996). "Chordoma: retrospective ...
Studies in animals using passive immunotherapy have been effective, and clinical studies using passive immunotherapy in those ... a retrospective study of 159 cases in Reunion Island from 2006-2012". PLOS Neglected Tropical Diseases. 9 (3): e0003603. doi: ... 1,118,763 suspected cases and 24,682 confirmed cases were reported by the PAHO.[73] ... August 2012). "Long-term chikungunya infection clinical manifestations after an outbreak in Italy: a prognostic cohort study". ...
Clinical decision support system[edit]. Clinical decision support systems are interactive computer programs designed to assist ... Retrospective diagnosis. The labeling of an illness in a historical figure or specific historical event using modern knowledge ... Diagnosis problems are the dominant cause of medical malpractice payments, accounting for 35% of total payments in a study of ... are performed or scheduled in part to confirm or disprove the diagnosis but also to document the patient's status and keep the ...
The Nature study was itself reproduced in the journal PLOS ONE, which confirmed that a majority of cancer researchers surveyed ... Cross-sectional study vs. Longitudinal study, Ecological study. *Cohort study *Retrospective. *Prospective ... Academic clinical trials. *Clinical study design. Controlled study. (EBM I to II-1; A to B). *Randomized controlled trial * ... In 2012, a study by Begley and Ellis was published in Nature that reviewed a decade of research. That study found that 47 out ...
"Population-based study of invasive disease due to beta-hemolytic streptococci of groups other than A and B". Clinical ... a 15-year retrospective survey". Clinical Microbiology and Infection. 21 (2): 171-8. doi:10.1016/j.cmi.2014.08.019. PMID ... However, the above characteristics are not unique to S.dysgalactiae, and further testing is required to confirm the species ... and it was linked to a majority of the cellulitis cases in a recent study. The clinical presentation among invasive disease is ...
... retrospective study". The Lancet Rheumatology. 2 (11): e698-e711. doi:10.1016/s2665-9913(20)30276-9. ISSN 2665-9913. PMC ... Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies". ... "Total confirmed deaths due to COVID-19 per million people". Our World in Data. 18 Mart 2020 tarihinde kaynağından arşivlendi. ... a retrospective cohort study". The Lancet. Elsevier BV. doi:10.1016/s0140-6736(20)30566-3. ISSN 0140-6736.. ...
Results from specific candidate gene studies have been mixed. For instance, in a study of nicotine use Johnson and colleagues ... "The extent and effects of peer pressure among high school students: A retrospective analysis". Journal of Youth and Adolescence ... Their findings confirm the arbitrary nature of his selection and evaluation of existing records as opposed to a more holistic ... "Clinical Psychology Review. 44: 45-59. doi:10.1016/j.cpr.2015.11.002.. ...
20-year retrospective analysis". Journal of Toxicology: Clinical Toxicology. 40 (6): 715-57. doi:10.1081/CLT-120014646. PMID ... "Studies in the Amanitaceae. Retrieved 22 May 2007.. *^ a b Bresinsky A, Besl H (1990). A Colour Atlas of Poisonous Fungi. Wolfe ... There are records from further east in Asia but these have yet to be confirmed as A. phalloides.[28] ... A 15-year retrospective analysis and follow-up evaluation of 105 patients". Clinical Toxicology. 45 (5): 539-42. doi:10.1080/ ...
... a case-control and retrospective cross-sectional MRI study at 3T". PLOS One. 9 (4): e93814. Bibcode:2014PLoSO...993814S. doi: ... requiring that the clinical presentation be periodically reviewed to confirm accuracy of the diagnosis.[29][59] ... but this finding was not widely accepted until it was confirmed by further studies published by Rolf Hassler in 1938.[16] The ... is the most commonly used metric for clinical study. A modified version known as the MDS-UPDRS is also sometimes used. An older ...
Studies in Ohio and Michigan soon confirmed her findings[20] pointing to the use of aspirin during an upper respiratory tract ... A retrospective study of 49 survivors of cases diagnosed as "Reye's Syndrome" showed that the majority of the surviving ... 2001). "Incidence of Reye's syndrome in France: a hospital-based survey". Journal of Clinical Epidemiology. 54 (8): 857-62. doi ... During the 1980s, a case-control study carried out in the United Kingdom also demonstrated an association between Reye syndrome ...
The elder Sternberg insisted upon a rigorous study of the Hebrew language, limiting his son to religious studies on top of his ... The King Steps Out is the only movie that he insisted be expunged from any retrospective of his work.[232] ... "clinical and Spartan" in its cinematic technique made a significant impression on French filmmakers: Underworld was surrealist ... and even his enemies confirm his artistic presence in every foot of the film he shot."[239] ...
Xue JL, Fan MW, Wang SZ, Chen XM, Li Y, Wang L (September 2005). "A clinical study of 674 patients with oral lichen planus in ... Hietanen J, Paasonen MR, Kuhlefelt M, Malmström M (May 1999). "A retrospective study of oral lichen planus patients with ... To confirm the diagnosis of cutaneous lichen planus, a skin biopsy can be done. A punch biopsy of sufficient depth to the mid ... Eisen D (February 2002). "The clinical features, malignant potential, and systemic associations of oral lichen planus: a study ...
Advances in genetic technology allow clinical geneticists to link an estimated 40% of ASD cases to genetic causes; in one study ... "A retrospective analysis of the clinical case records of 'autistic psychopaths' diagnosed by Hans Asperger and his team at the ... This will require a comprehensive team evaluation to either confirm or exclude a diagnosis of AS. This team usually includes a ... A total population study". J Child Psychol Psychiatry. 34 (8): 1327-50. doi:10.1111/j.1469-7610.1993.tb02094.x. PMID 8294522.. ...
... a meta-analysis of prospective cohort studies". Diabetes Research and Clinical Practice. 89 (3): 309-19. doi:10.1016/j.diabres. ... a meta-analysis of retrospective cohort studies". Chinese Medical Journal. 125 (23): 4301-6. PMID 23217404.. ... diagnosis is in doubt antibody testing may be useful to confirm type 1 diabetes and C-peptide levels may be useful to confirm ... "World Journal of Clinical Cases. 3 (6): 504-9. doi:10.12998/wjcc.v3.i6.504. PMC 4468896 . PMID 26090370.. ...
There is a tentative association between long term use and dementia which requires further study to confirm.[23] ... 2011). "Association between proton pump inhibitor use and anemia: a retrospective cohort study". Digestive Diseases and ... "British Journal of Clinical Pharmacology. 64 (6): 819-823. doi:10.1111/j.1365-2125.2007.02927.x. PMC 2198775. PMID 17635502.. ... "Clinical Drug Investigation. 25 (6): 391-399. doi:10.2165/00044011-200525060-00004. PMID 17532679. Archived from the original ...
Adler I (1912). Primary malignant growths of the lungs and bronchi: a pathological and clinical study. New York: Longmans, ... retrospective study using Millennium Cohort". BMC Public Health. 7: 81. doi:10.1186/1471-2458-7-81. PMC 1884144. PMID 17506887. ... and a study by the World Health Organization also confirmed these findings.[211] ... Case-control studies were published in Germany in 1939 and 1943, and one in the Netherlands in 1948. A case-control study on ...
Forensic social work is the specialist study of social work theories and their applications to a clinical, criminal justice or ... Jefferys confirmed that the DNA profiles were identical for the two murder semen samples. To find the perpetrator, DNA samples ... Internal studies and an outside study by the National Academy of Sciences found that the technique was unreliable due to ... Forensic accounting is the study and interpretation of accounting evidence.. *Forensic aerial photography is the study and ...
Studying earthquakes has shown to be a difficult task when considering all the limitations created by natural disasters.[251][ ... The court subsequently ruled in favour of Phillipstown and overturned the merger.[214] The plans were confirmed in February ... 252][253][254][255][256][257] Clinical interviews are difficult because of the widespread damage to infrastructure and roads, ... Retrospective self-report is affected greatly by the individual's current state of distress.[257] The displacement of large ...
A 2006 retrospective study of 14,564 Medicare recipients showed that warfarin use for more than one year was linked with a 60% ... Thus, common clinical indications for warfarin use are atrial fibrillation, the presence of artificial heart valves, deep ... They confirmed their results by synthesizing dicoumarol and proving in 1940 that it was identical to the naturally occurring ... A 1999 study in 572 women taking warfarin for deep venous thrombosis, risk of vertebral fracture and rib fracture was increased ...
The NIH Clinical Center will study individuals with ME/CFS, and the National Institute of Neurological Disorders and Stroke ( ... The MRC confirmed to the Group that, from April 2003 to November 2006, it has turned down 10 biomedical applications relating ... retrospective analysis of samples from an established cohort". BMJ. 340: c1018. doi:10.1136/bmj.c1018. PMC 2829122 . PMID ... in the three studies that considered this outcome." .... "In five studies, a worsening of symptoms during the period of follow- ...
Newer research approaches are currently being studied, including preclinical and clinical investigations into the use of an ... retrospective, cohort study". The Lancet. Oncology. 20 (5): 674-685. doi:10.1016/S1470-2045(18)30931-8. PMID 30885458.. ... An association was confirmed between total cellular manganese contents and their variation, and clinically-inferred ... "Journal of Applied Clinical Medical Physics. 17 (1): 272-282. doi:10.1120/jacmp.v17i1.5901. PMC 5690191. PMID 26894364.. ...
Thirty of these 40 persons participated in the retrospective cohort study. Twenty-six persons had clinical cases; eight had ... laboratory-confirmed cases; and four did not become ill. The attack rate in the study participants was 87% (26 of 30 persons), ... i. e., the ratio of ill to non-ill persons in the retrospective cohort study was not substantially distorted. All participants ... Studies on a newly emerging protozoal pathogen: Cyclospora cayetanensis. J Egypt Soc Parasitol. 1999;29:575-86.PubMed ...
Aims This study aimed to describe key epidemiological parameters of COVID-19 in Hong Kong. Methods We extracted data of ... confirmed COVID-19 cases and their close contacts from the publicly available information released by the Hong Kong Centre for ... Our study highlights the transmission risk of social interaction and pivotal role of physical distancing in suppressing the ... Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020;368:m1091. ...
Retrospective evaluation of a pharmacist- managed anticoagulation clinic. Am J Hosp Pharm 1985; 42:304-308.. ... Largest study yet confirms benefits of clinical pharmacy managed anticoagulation service James B. Groce III, Pharm.D., CACP. ... Patients in the study who were cared for by anticoagulation clinic spent more time with their INRs in range. (If you are not ... A recent study looked at the care received by patients taking warfarin (brand name Coumadin). There were two groups of patients ...
Retrospective evaluation of a pharmacist- managed anticoagulation clinic. Am J Hosp Pharm 1985; 42:304-308.. ... Largest study yet confirms benefits of clinical pharmacy managed anticoagulation service James B. Groce III, Pharm.D., CACP. ... Witt1 and colleagues in their observational cohort study evaluated the occurrence of anticoagulation therapy related ... Effect of a centralized clinical pharmacy anticoagulation service on the outcomes of anticoagulation therapy. Chest 2005; 125: ...
Studies have reported short-term results confirming an early high occlusion rate with no major complications when strict ... The main drawbacks of this study were its retrospective, single-center design. These researchers stated that larger, ... Studies with long-term follow-up are needed. Fourth, because of the limited number of 3-arm studies, many pooled estimates of ... All patients have undergone clinical and echocardiographic follow-up and all devices remain in position. Early bubble studies ( ...
Our laboratory studies confirm the existence of Lyme spirochetes in semen/vaginal secretions. Whether or not further clinical ... studies with a larger statistical group will support the hypothesis of sexual transmission remains to be seen. A retrospective ... These preliminary findings warrent futher study. Current a statistical design study to evaluate the possibility of sexual ... As with Lyme, studies on chronic syphilitic infection indicate that bacteria can evade the hostsimmune system by one or more ...
Pulmonary Infections With Mycobacterium avium-intracellulare in Women With Confirmed or Suspected Malignancy: A Retrospective ... However, the aim of this study is to describe immunodefi cient cancer patients identifi ed with HIS and discuss the debatable ... Thought you might appreciate this item(s) I saw at Infectious Diseases in Clinical Practice.. ... Observational Study, 1987-2011. Cheema, Asima; Yacoub, Abraham; Beltrame, Anna; More Cheema, Asima; Yacoub, Abraham; Beltrame, ...
... confirms that omega-3 fatty acid medicines are not effective in preventing further cardiovascular problems in patients who have ... The review also gathered more recent randomised controlled clinical trials, retrospective cohort studies and meta-analyses in ... PureWay-C™ is a proprietary, proven form of vitamin C, documented with research studies (in-vitro and clinical trials) showing ... GISSI Prevenzione study​. The original recommendation is based on a review started on 22 March 2018 at the request of the ...
Retrospective single center clinical observation study. Outcome measure: Death. Inclusion criteria: histological confirmed TEN ... A clinical criterion for TEN is epidermal necrosis and detachment of more than 30% TBSA. Some cases of TEN involve mucosa as ... Conclusions: Our study suggests that mucosal affection and TBSA ,50% are associated with increased mortality in our patients. ... Our results prompted us to propose at best a prospective multicenter study evaluating the role of mucosal affection in toxic ...
Clinical and experimental studies have established that delay in treatment of urinary infection is a factor in the development ... In 41 there was delay in diagnosis; there was delay in treating a confirmed infection in 45; no antibacterial prophylaxis was ... Retrospective study of children with renal scarring associated with reflux and urinary infection BMJ 1994; 308 :1193 ... Design: Retrospective study of medical records and discussion with parents.. Setting: Outpatient departments of two teaching ...
... a french multicenter retrospective study in wet AMD patients treated with Verteporfin PDT plus Ranibizumab in routine clinical ... Franck Rumen, Elisabeth Latour, Aurore Study Group; AURORE STUDY: a french multicenter retrospective study in wet AMD patients ... AURORE STUDY: a french multicenter retrospective study in wet AMD patients treated with Verteporfin PDT plus Ranibizumab in ... Confirm × This feature is available to authenticated users only.. Sign In or Create an Account × ...
Comparative Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt; Research Support, U.S. Govt, Non-P. ... These findings were confirmed in a validation cohort of 113 patients with AD. ... Neuropathologically defined subtypes of Alzheimers disease with distinct clinical characteristics: a retrospective study.. ... Neuropathologically defined subtypes of Alzheimers disease with distinct clinical characteristics: A retrospective study ...
Longitudinal and systematic clinical studies are necessary to confirm these results. ... Within the limits of the present study, it was found that well-planned ISBRPD was clinically appropriate. ... There was no failed implant and all implants were functioning without clinical mobility. Marginal bone loss of ISCRPD (1.44 ± ... This study was performed to make comparative analysis of the clinical findings between the two different types of the implant- ...
Recent technological advances in radiation oncology have led to the clinical implementation of image-guided radiotherapy, ... For example, a retrospective study by Wronski et al. revealed a median survival of 4.4 months from diagnosis following WBRT for ... two subsequent prospective clinical trials failed to confirm such benefit. In the first, van der Werf-Messing et al. reported a ... A study by the Copenhagen Renal Cancer Study Group. Scand. J. Urol. Nephrol. 1987, 21, 285-289. [Google Scholar] ...
... and other potential risk factors were recorded for the purpose of this study. There were no differences between the union and ... Future perspective studies and clinical trials might further confirm our observation.. We also found that fracture without ... A more horizontal fracture line was associated with internal fixation failure in clinical and mechanical studies [19]. However ... Metformin Prevents Nonunion after Three-Cannulated-Screw Fixation in Displaced Femoral Neck Fractures: A Retrospective Study, ...
in a prospective study and by Berin et al. in a retrospective one. They showed that the flare-up agonist and antagonist ... Clinical pregnancy rate was higher in the long GnRH protocol compared with the modified short protocol, but the difference was ... noticed no significant differences as regards with any outcome parameters (36-38). These results were confirmed by Devesa et al ... Another retrospective study compared a microdose flare-up regimen with a long luteal protocol with decreasing doses of GnRH ...
Clinical analysis of 20 patients with non-Hodgkin lymphoma and autoimmune hemolytic anemia: A retrospective study ... Pilot Study of Hyperfractionated Dosing of Lutetium-177-Labeled Antiprostate-Specific Membrane Antigen Monoclonal Antibody J591 ... Intrahepatocellular crystal storing mimicking a clinical liver disease during monoclonal gammopathy: report of a case and ... Descriptive analysis of clinical and pathologic factors related to irN was performed (n=32); the effect of these on the irN ...
Background The objective of this study was to carry out a systematic review and meta-analysis of embryologic and clinical ... These findings were further confirmed by relevant retrospective studies and sensitivity analyses (Table 3). ... All studies comparing open versus closed vitrification of oocytes and/or embryos on embryologic and clinical reproductive ... There were 12 studies (eight prospective and four retrospective studies) included in quantitative analysis. These consisted of ...
Surgery was not confirmed for ten. Two hundred patients receiving prompt vascular surgery were the study group. ... Design: Retrospective, observational study.. Setting: University medical center.. Patients: Two hundred fifty-four consecutive ... Study Objective: To determine whether clinical markers and preoperative dipyridamole-thallium imaging are both useful in ... Combining Clinical and Thallium Data Optimizes Preoperative Assessment of Cardiac Risk before Major Vascular Surgery Kim A. ...
... a retrospective study. Clinical and epidemiologic characteristics of hospitalized patients with laboratory-confirmed ... Clinical and epidemiologic data pertaining to hospitalized patients of all ages with laboratory-confirmed RSV infection by PCR ... Clinical and epidemiologic data pertaining to hospitalized patients of all ages with laboratory-confirmed RSV infection by PCR ... 2016- PLoS One- Clinical and Epidemiologic Characteristics of Hospitalized Patients with Laboratory-Confirmed Respiratory ...
... the first visit during the study). Inclusion criteria were confirmed by chart review. Demographic and clinical data were ... Our study has limitations. First, because the study design is retrospective, information obtained is dependent on existing ... Our findings confirm the results in 2 similarly designed studies (4,5). In the first, time to HbA1c goal was 23 days shorter ... Our retrospective cohort study was conducted between January 2017 and July 2019, at the University of South Florida (USF) ...
First, this study was retrospective in design. Out of 28 charts reviewed, clinical records were incomplete with data missing in ... Second, a large-scale longitudinal prospective study would confirm the validity of these findings. Third, follow-up time was ... Of all the studies, 23 have evidence level above case series. Of the 23 studies, 19 were on SPG block, 1 study on RFA, and 3 ... These researchers stated that this study was limited by being a retrospective study, and by having a relatively small sample ...
However, most cases were identified by using clinical criteria, and few were bacteriologically confirmed. ... In fact, until 2004, no studies on nosocomial TB in India had been published. Table 1 summarizes the results of recent studies ... In a retrospective review of healthcare workers who underwent anti-TB treatment in a tertiary care hospital in Vellore, ... In this article, we focus on India as a case study and review available studies on nosocomial TB, describe factors that ...
Methods: A retrospective cohort study was performed. Clinical data of 30 colonic slow transit constipation patients aged ≥70 ... After confirming that there was no other organ metastasis, right hemicolectomy was performed for radical surgery. Five months ... Analysis of 266 cases in a multicenter collaborative retrospective clinical study.. Fetched: May 29th, 2019, 5:00am GMT. ... Analysis of 266 cases in a multicenter collaborative retrospective clinical study. Ann Gastroenterol Surg. 2019 May;3(3):291- ...
This study aims to retrospectively describe and compare treatments of blood culture-confirmed and unconfirmed, but suspected, ... This study aims to retrospectively describe and compare treatments of blood culture-confirmed and unconfirmed, but suspected, ... GliomaDB includes 21,439 samples from 4304 patients and integrates genomic, transcriptomic, epigenomic, clinical, and gene-drug ... Antibiotic Treatment of Suspected and Confirmed Neonatal Sepsis Within 28 Days of Birth: A Retrospective Analysis. *. ...
A retrospective case study was conducted in one designated hospital for children with SARS-CoV-2 infection in Wuhan. The study ... All of children had a direct exposure to at least one family member with confirmed SARS-CoV-2 infection. Most common symptoms ... The requirement for informed patient consent was waived by the ethics committee due to retrospective case study and the ... Epidemiological and Clinical Characteristics of 74 Children Infected with SARS-CoV-2 in Family Clusters in Wuhan, China. 21 ...
This retrospective study assessed computed tomography (CT) findings that are most predictive of appendicitis when the appendix ... Presence or absence of appendicitis was confirmed by chart review of clinical or surgical outcomes. Logistic regression was ... Materials and Methods In this retrospective study, Doppler waveforms were obtained from intramural appendiceal arteries ... The classification scheme used in this study may be a useful tool for the interpretation of arterial phase CT studies. ...
In Situ Vaccination With a TLR9 Agonist Induces Systemic Lymphoma Regression: A Phase I/II Study JOURNAL OF CLINICAL ONCOLOGY ... This retrospective study assessed computed tomography (CT) findings that are most predictive of appendicitis when the appendix ... Presence or absence of appendicitis was confirmed by chart review of clinical or surgical outcomes. Logistic regression was ... Materials and Methods In this retrospective study, Doppler waveforms were obtained from intramural appendiceal arteries ...
The clinical significance of these findings remains unclear. Larger studies are warranted to confirm the safety of adenosine ... In a retrospective study, Salhab et al showed that initial hypoglycemia (, 40 mg/dL) is significantly associated with adverse ... A clinical and electroencephalographic study. Arch Neurol. 1976 Oct. 33(10):696-705. [Medline]. ... Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study ...
  • Methods: This retrospective study was carried out at a single institution. (
  • Methods We conducted a retrospective cohort study including 20,293 laboratory confirmed cases of COVID-19 in Portugal to 28 April 2020, electronically through the National Epidemic Surveillance System of the Directorate-General of Health(DGS). (
  • Material and Methods: The Retrospective study was carried out on 51 patients suffering from pleural effusion in B.J.M.C. Ahmedabad during May to Aug-2012. (
  • Current methods for diagnosing military mTBI often rely on using subjective tools and retrospective self-reports, which can overlap with symptoms of posttraumatic stress disorder (PTSD) and depression. (
  • Methods: This multicentre, retrospective, cohort study included adult patients (aged ≥18 years) with diagnosis of a WHO-defined haematological malignancy admitted to 66 Italian hospitals between Feb 25 and May 18, 2020, with laboratory-confirmed and symptomatic COVID-19. (
  • METHODS: MR imaging studies in three patients with an autopsy-based diagnosis of Alexander disease were analyzed to define MR criteria for the diagnosis. (
  • Much discussion among researchers has taken place about how study recruitment through social media and online networks could help assemble large and demographically diverse patient groups more quickly and inexpensively than they could using traditional outreach methods, but just how and how well it would work has raised many questions. (
  • METHODS: Radiographic and clinical examination, including testing reaction to cold, showed that both teeth were immature and in a stage of reversible pulpitis. (
  • This retrospective, mixed-methods study assessed the learning styles, relationship to fieldwork performance, and learning adaptability of graduate, nontraditional occupational therapy students. (
  • This study presents a novel approach to learning styles and its implications for students' fieldwork performance and learning through a mixed-methods approach. (
  • This study, used a retrospective, mixed-methods correlational design. (
  • Methods Patients given opioid treatment by emergency medical services with confirmed STEMI were included in this secondary, retrospective cohort analysis of the Air versus Oxygen in Myocardial Infarction (AVOID) study. (
  • Methods We performed a retrospective study of 126 patients with confirmed COVID-19 with severe or critical disease who treated in the ICU from February 4, 2020, to April 16, 2020. (
  • Methods: Tow hundred and two eligible pre-diabetic Qatari patients who have undergone bariatric surgery in 2016 and satisfied the inclusion and exclusion criteria of the study were analyzed. (
  • Methods: A retrospective analysis was conducted on adult HIV patients with a history of mental illness enrolled at an urban HIV clinic in Johannesburg, South Africa who discontinued care. (
  • METHODS: Clinical retrospective review of infected haemato-oncology patients was undertaken. (
  • Observational studies are often retrospective and are used to assess potential causation in exposure-outcome relationships and therefore influence preventive methods. (
  • We examined whether implementing pre-enrollment orientation sessions was associated with higher intervention adherence and retention in a pragmatic clinical trial.Methods: The trial tested an intensive behavioral intervention for patients with chronic pain on long-term opioids. (
  • Results from the National Aflibercept Audit assessing the outcomes associated with switching patients from other anti-VEGF treatments to aflibercept in the NHS clinical setting were also presented. (
  • Retrospective chart review was performed, and functional outcomes were assessed using the AOFAS midfoot score. (
  • Our study shows good clinical outcomes with low complications. (
  • Introduction Determinants of hospitalization, intensive care unit (ICU) admission and death are still unclear for Covid-19 and only a few studies have adjusted for confounding for different clinical outcomes including all reported cases in a country in the analysis. (
  • We used routine surveillance data from Portugal to identify risk factors for COVID-19 outcomes, in order to support risk stratification, clinical and public health interventions, and to improve scenarios to plan health care resources. (
  • To identify the clinical features and outcomes of infrequently reported leptomeningeal carcinomatosis (LMC) of gastric cancer. (
  • This study aimed to evaluate the ultrasonographic features of uterine scar dehiscence in pregnant women and maternal and neonatal outcomes. (
  • These new findings support a growing library of evidence that kidney disease patients on HDx therapy enabled by Theranova may experience improved clinical outcomes and lower healthcare resource utilization. (
  • Interpretation: This study adds to the evidence that patients with haematological malignancies have worse outcomes than both the general population with COVID-19 and patients with haematological malignancies without COVID-19. (
  • In this large study, we confirmed that patients who are MRD-negative prior to alloHCT achieve superior outcomes," Dr. Pavlu reported. (
  • The documented outcomes had substantial discrepancies across the studies, most likely due to methodological differences, study size and disparate outcome definitions. (
  • Renal parameters reported Table?2 illustrates that renal outcomes were MS417 variably defined across the studies. (
  • In about 60% of the included studies, eGFR (using one of or a combination of CockCroft-Gault, MDRD, CKI-EPI formulae) was used as a measure of renal outcomes. (
  • Conclusions AKI duration is a useful parameter to predict of worse clinical outcomes in elder patients with COVID-19 in the ICU. (
  • Study outcomes were bFFS, defined as time from diagnosis to biochemical recurrence or all-cause death, and overall survival (OS). (
  • Tracing patients through home visits proved to be an effective means to confirm the magnitude of patients lost to follow up, ascertain their outcomes, and elucidate the reasons for discontinuing care. (
  • Criteria included studies of adolescents (age ≤ 18 at baseline) from either epidemiological or clinical samples, incorporating a longitudinal design, with predictors and outcomes of interest, including both NSSI and BPD diagnosis/symptoms/traits. (
  • Since NPT is now applied quite commonly throughout medical schools, it seemed timely to provide some guidance for obtaining the most effective NPT outcomes in clinical anatomy education and for medical education more widely. (
  • We routinely post information that may be associated with worse clinical outcomes when administered to hospitalized patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of IBRANCE and potential pediatric exclusivity for IBRANCE, that involves substantial risks and uncertainties that could cause actual results to differ materially due to COVID-19, OR who require oxygen therapy due to. (
  • The main purpose of the UK TAVI program was to define the characteristics of a real-world TAVI patient population, regardless of technology or access route, and to capture and report clinical outcomes on TAVI procedures performed within the United Kingdom. (
  • 7 More recently, as summarized in table 1, numerous additional observational studies have confirmed that low testosterone levels are associated with heart disease and that testosterone therapy confers beneficial effects, or is at worst neutral in terms of cardiovascular disease outcomes and mortality. (
  • The Lancet study sought to assess the effect of testosterone therapy on overall mortality and cardiovascular events in men with long-term follow-up using a time-varying testosterone exposure, in order to find out if duration of testosterone treatment impacts outcomes. (
  • Objectives To assess the clinical impact on drug-related negative outcomes of a pharmaceutical care programme focusing on the resolution of potential drug-related problems, initiated in the emergency department for patients with heart failure (HF) and/or chronic obstructive pulmonary disease (COPD). (
  • Conclusion A pharmaceutical care programme focusing on resolving potential drug-related problems initiated at the emergency department has a favourable clinical impact, as it reduces the number and prevalence of drug-related negative outcomes. (
  • For their study, Gyawali's group wanted to update the outcomes reported in this 2018 assessment. (
  • conducted a meta-analysis (10 studies including 9,890 subjects) to estimate the association between hypertensive medication and COVID-19 outcomes. (
  • We defined six subtypes of bone turnover and showed that among hospitalized orthogeriatric patients these subtypes differed substantially in terms of clinical characteristics, including prevalence of nonvertebral fractures, especially HF, chronic comorbid conditions and in-hospital outcomes. (
  • 7 , 8 Studies from north-east Scotland found inferior treatment of BCC in primary care, but that the GPs' excision rates for SCC were as good as secondary care skin specialists, and that long-term outcomes for patients with MM were no different if the initial diagnostic excision was undertaken in primary or secondary care. (
  • To define the epidemiology, clinical characteristics and outcomes of patients with MRSA SA compared to non-MRSA SA patients. (
  • Our study confirms that MRSA SA patients tend to be older, have more comorbidities and worse outcomes than those infected with other organisms. (
  • Over the years, EQUIA has inspired a number of prominent research groups to evaluate its clinical performance in several short- and long-term trials. (
  • Clinical performance during 48 months of two current glass ionomer restorative systems with coatings: a randomized clinical trial in the field Trials. (
  • The postoperative survival periods were considerably shorter than those reported from large cooperative clinical trials. (
  • 1-4) reflecting the results seen in the pivotal VIEW clinical trials. (
  • This is the first time in the treatment of wet AMD that results from real-world NHS clinical audits have begun to approach those seen in randomised clinical trials, demonstrating the benefits to patients and ophthalmologists of a proactive fixed dosing regime in the first year of treatment. (
  • Those results compare reasonably to the mean visual acuity gain of 8.4 letters seen in the pivotal VIEW clinical trials for aflibercept. (
  • these results reflected those seen in the VIEW clinical trials. (
  • The results from this audit further support the use of EYLEA in clinical practice and demonstrate that results seen in clinical trials can be replicated in NHS clinics. (
  • The serum HBV DNA quantitative test is the current method used in clinical trials, but while the serum HBV DNA does not reflect intrahepatic HBV cccDNA, a liver biopsy does. (
  • I understand that all clinical trials and any other prospective interventional studies must be registered with an ICMJE-approved registry, such as (
  • Under the circumstances, a clearer understanding of the challenges associated with TBI, how it manifests, and the use of wearables and sensors in capturing physiological data can lead to better designed military-related TBI clinical trials. (
  • Randomized clinical trials are needed to confirm the observed effect. (
  • Hydroxychloroquine, a malaria drug that's since proven ineffective against COVID-19 in clinical trials, was tried in 15 patients. (
  • This variation highlights the need for more excessive-high quality, large-scale clinical trials to help establish standardized dosing and clinical usage guidelines for CBD therapy. (
  • A formal multicenter registry will ultimately be necessary to recruit patients early in the acute phase of their condition, and subsequently randomized clinical trials may become feasible. (
  • Non-cancer deaths should be considered when selecting patients for combination therapies and in the study design ofclinical trials. (
  • Multiple large multi-centre trials have confirmed a survival benefit associated with the use of HEMS 2-4 . (
  • Although recent analysis has called into question the validity of these guidelines [ 8 ], adjuvant chemoradiation remains the standard of care for these high-risk patients, pending further clinical trials. (
  • Randomized clinical trials in humans are not possible due to ethical considerations, therefore evidence in controlled trials of the effectiveness of hydroxocobalamin for the treatment of cyanide poisoning was obtained primarily from studies in animals. (
  • In recent years, experience on the application of adaptive designs in confirmatory clinical trials has accumulated. (
  • In 2007, the European Medicines Agency (EMA) provided guidance on confirmatory clinical trials with adaptive (or flexible) designs. (
  • In order to better understand how adaptive trials are implemented in practice and how they may impact medicine approval within the EMA centralised procedure, we followed on 59 medicines for which an adaptive clinical trial had been submitted to the EMA Scientific Advice (SA) and analysed previously in a dedicated EMA survey of scientific advice letters. (
  • We also discuss the current regulatory perspective as regards the implementation of adaptive designs in confirmatory clinical trials. (
  • In order to provide regulatory guidance, the European Medicines Agency (EMA) released the "Reflection paper on methodological issues in confirmatory clinical trials planned with an adaptive design" in 2007 [ 11 ] and co-organised two workshops on "adaptive design in confirmatory trials" with the European Federation of Pharmaceutical Industries and Associations (EFPIA) in 2008 and 2009. (
  • As confirmatory adaptive designs are now routinely used in clinical trials, in addition to regulatory guidance (which focus mainly on planning aspects), reporting guidance in the form of a Consolidated Standards of Reporting Trials (CONSORT) extension is under development [ 14 ]. (
  • Circulating tumor DNA (ctDNA) has the potential to cost-efficiently accelerate precision medicine trials to improve clinical efficacy and diminish costs and toxicity. (
  • ctDNA profiles appear to mirror the genomic landscape of metastatic prostate cancer tissue and may cost-efficiently provide somatic information in clinical trials designed to identify predictive biomarkers. (
  • However, intronic sequencing of the interrogated tumor suppressors challenges the ubiquitous focus on coding regions and is vital, together with profiling of synchronous white blood cells, to minimize erroneous assignments which in turn may confound results and impede true associations in clinical trials. (
  • So far, data from two randomised controlled trials and several large multi-centre TAVI registries have built the cornerstones for our clinical decision-making process. (
  • 6- 8 To the contrary, in randomized controlled trials - the gold standard study type in clinical research - performed in subjects with metabolic derangements (which constitute about half of the general population 9- 12 ) a protective effect of testosterone therapy on cardiovascular disease risk was observed. (
  • The remainder of the drugs granted accelerated approval had confirmatory studies that used surrogate endpoints that were either different from its preapproval studies (21%) or the same as those used in the preapproval studies (20%), or the trials did not confirm clinical benefit (9%), were delayed (5%), pending (11%), ongoing (10%), terminated, or not required. (
  • Drugs approved via this pathway are often required to undergo post-approval confirmatory trials to evaluate their clinical benefits. (
  • Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question. (
  • A third cohort of participants (n=45) will participate in a randomized clinical trials to further examine feasibility and efficacy. (
  • Interactive group-based orientation sessions: A method to improve adherence and retention in pragmatic clinical trials. (
  • Background: Intervention adherence and trial retention are challenging for clinical trials testing intensive behavioral interventions. (
  • The EQUIA Forte multicenter study (Miletic I. et al16) compares the glass-hybrid to a nano-hybrid resin composite (Tetric EvoCeram, Ivoclar Vivadent) and the two-year interim results have shown similar clinical performance for both materials. (
  • Due to the fact this study was a retrospective, multicenter study, we checked out the medical records of the individuals but we couldn't get information and facts on variables including the history of use of blockers before TWOC, symptoms of LUTS, and so on. (
  • The researchers conducted this retrospective multicenter study to explore whether the prevalence of post-alloHCT MRD differed when a patient underwent conditioning with total-body irradiation versus chemotherapy. (
  • Prospective, observational, multicenter study. (
  • Olegário C et al , Glass carbomer and compomer for ART restorations: 3-year results of a randomized clinical trial Clin Oral Investig. (
  • Interventional studies are often prospective and are specifically tailored to evaluate direct impacts of treatment or preventive measures on disease. (
  • The 30-day study period commenced after the first confirmed positive case was detected at the hospital on 21st March 2020, until 19th April 2020. (
  • The Ethics Committee of the Local Health Unit of the Province of Trento on the 3rd of July 2020 reviewd the ppaer and came to the conclusion, that given the nature of the study (retrospective analyses of a database in order to improve the quality of the health service) it does not fall under its competence. (
  • WEDNESDAY, June 3, 2020 (HealthDay News) -- If a child is infected with the new coronavirus, being obese appears to greatly raise the odds for developing a severe form of COVID-19, a new study finds. (
  • This is a hospital based cross-sectional study on 1190 deceased patients of coronavirus disease in a tertiary care hospital of central India which is a dedicated covid hospital from 11 March 2020 to 28 February 2021. (
  • The authors of 1 2020 article reviewed eight studies investigating CBD's role in treating varied anxiety disorders. (
  • Objectives: To describe the clinical presentation, delay in diagnosis and treatment initiation, and outcome of culture-confirmed childhood tuberculosis. (
  • Ultrasound was routinely performed to confirm the diagnosis. (
  • In patients with confirmed diagnosis of DTAT, persistent despite conservative treatment, we proceeded with surgical intervention during which we released the tendon by opening the distal extensor retinaculum. (
  • Although 115 of 517 deceased infants (22%) had a confirmed diagnosis of a genetic disorder, only 61 of 115 deaths (53%) were attributed to , codes representing congenital anomalies or genetic disorders (Q00-Q99) as the underlying cause of death because of inconsistencies in death reporting. (
  • Studies have confirmed diagnostic role of Adenosine deaminase for early diagnosis of pleural tuberculosis in high prevalence countries like India. (
  • So this was best cut off point for ADA level to confirm diagnosis. (
  • This study suggests that the detection of cmDNA allows earlier diagnosis of IWM in severely ill burn patients and earlier initiation of treatment. (
  • We initiated a multiinstitutional survey of MR abnormalities in both presumed and confirmed cases of Alexander disease to assess the possibility of an MR-based diagnosis. (
  • Medical records were collected and reviewed, the original diagnosis was independently confirmed by review of imaging studies, and health status (both interval and current) was assessed via specially designed questionnaires and validated assessment tools. (
  • One patient (4.5%) died within 8 months after a confirmed diagnosis. (
  • said that barium study has 91% sensitivity for diagnosis of colonic malignancies, which is comparable. (
  • The aim of this study was to investigate the influence of factors such as concomitant use of photosensitizing agents, diagnosis, and combination with acitretin in patients with psoriasis on the frequency and severity of adverse effects in patients with a low MED to narrowband UV-B phototherapy. (
  • Serum β2M may be a useful biomarker for clinical diagnosis, follow-up and prognosis of PCa. (
  • However, there are concerns of insufficient GP training in the diagnosis and especially treatment of skin cancer, with most studies reporting higher rates of incomplete excision for NMSC in primary care. (
  • Epilepsy is primarily a clinical diagnosis, but the EEG may provide strong support by the findings of inter - ictal Epileptogenic discharge METHOD: All the adult EEGs requested at Dr George Mukhari psychiatric hospital, over a 36 month period,were reviewed to describe the outcome of the requested EEG reports. (
  • Data were extracted from the EEG request form and the patients' clinical files, which reported on the clinical reason for the EEG test, nature of psychiatric diagnosis of patients, the psychiatric treatment received prior to the EEG test and the nature of the EEG results RESULTS: There were 111 EEG reports analysed, and 69 EEG reports for males and 42 EEG reports for females. (
  • In the practice of psychiatry it is not recommended to routinely order an EEG to exclude a diagnosis of epilepsy, more so to confirm a psychiatric diagnosis. (
  • This study is, to our knowledge, the largest case series to date of 2019-nCoV infections, with 99 patients who were transferred to Jinyintan Hospital from other hospitals all over Wuhan, and provides further information on the demographic, clinical, epidemiological, and laboratory features of patients. (
  • Fatiadou et al , A 3-year controlled randomized clinical study on the performance of two glass ionomer cements in Class II cavities of permanent teeth Quintessence Int. 2019;50(8):592-602. (
  • A retrospective study included eight patients with head-and-neck mucormycosis diagnosed over a 3-year period from December 2016 to March 2019. (
  • We calculated standardised mortality ratios between observed death in the study cohort and expected death by applying stratum-specific mortality rates of the Italian population with COVID-19 and an Italian cohort of 31 993 patients with haematological malignancies without COVID-19 (data up to March 1, 2019). (
  • Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. (
  • Retrospective Screening for SARS-CoV-2 RNA in California, USA, Late 2019. (
  • 1 The study "Effectiveness of medium cut-off versus high flux dialyzers: An inverse probability weighting cohort study," [Abstract #MO880] was an oral presentation at the 58 th European Renal Association - European Dialysis and Transplant Association (ERA-EDTA) Congress, June 5-8, 2021. (
  • We recorded epidemiological and clinical data. (
  • An epidemiological study of laboratory confirmed COVID-19 cases admitted in a tertiary care hospital of Pune, Maharashtra. (
  • The articles were grouped and reported on separately by population type (epidemiological vs. clinical), and directionality of relations. (
  • We identified two epidemiological and four clinical samples. (
  • This was a multicentre, retrospective, observational matched cohort study over a period of almost 14 years using a USA-based registry of in-hospital cardiac arrests. (
  • This study aimed to clarify the clinical characteristics of imported and second-generation cases. (
  • Cover sheet for essay mla format case of a study psychology Characteristics. (
  • We sought to determine if any clinical or radiographic characteristics can help predict stroke mimics among IVF candidates. (
  • Certain clinical characteristics appear predictive of stroke mimics, particularly normal computed tomographic angiography. (
  • The two groups were compared by demographic and clinical characteristics to confirm group comparability. (
  • Understanding the demographic and clinical characteristics of deceased COVID-19 patients could inform public health interventions focusing on preventing mortality due to COVID-19. (
  • Socio-demographic and clinical characteristics of deceased patients were recorded. (
  • The purpose of this study was to identify preoperative patient characteristics associated with the incidence of positive surgical margins or lymph node extracapsular extension (ECE), which necessitate adjuvant chemoradiation after transoral robotic surgery (TORS). (
  • Borderline personality disorder (BPD) in adolescent samples is similar to BPD in adults concerning clinical characteristics. (
  • Epidemiology and clinical characteristics of parainfluenza virus 3 outbreak in a Haemato-oncology unit. (
  • We conducted a retrospective study of all new cases of MT of all ages between January 1995 and December 2016. (
  • Here we present the results of a new study published in The Lancet Diabetes & Endocrinology on May 7 2016, which addressed some shortcomings in previous studies by analyzing effects based on duration of testosterone treatment. (
  • In June 2016 surveillance for microcephaly commenced to assist with the detection of potential cases of congenital Zika virus infection and during that time there were 21 confirmed cases - none had a relevant history to suspect congenital Zika virus infection, however, these cases are being followed up to determine the cause of microcephaly. (
  • They presented the results of this double-blind, placebo-controlled, phase 2 exploratory study in a poster at the 2016 Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology Annual Meeting on Supportive Care in Cancer. (
  • To characterize the incidence and mortality of the glioblastoma multiforme as it is seen at the primary care level, a retrospective study was done through the Georgia Tumor Registry on 299 patients with histologically confirmed supratentorial glioblastoma multiformes. (
  • Glucocorticoids Improve Enteral Feeding Tolerance in Pediatric Short Bowel Syndrome With Chronic Intestinal Inflammation In this retrospective study with 15 patients who had histologically-confirmed chronic intestinal inflammation, glucocorticoids (budesonide or prednisone) were associated with clinical improvement. (
  • This is a single-centre, prospective, randomised controlled, phase II clinical trial comparing slightly accelerated radiochemotherapy with photons to that with protons in patients with inoperable or locally advanced, cytologically or histologically confirmed NSCLC. (
  • Shape Characterization of Subdivision Surfaces - Case Studies K. Karciauskasˇ a Jorg Peters¨ b,∗, U. Reifc aUniversity of Vilnius bUniversity of Florida cDarmstadt University of Technology Abstract For subdivision surfaces, it is important to characterize local shape near flat spots and points However, the complete profiling of COVID-19 related ocular symptoms and diseases are still missing. (
  • On average, the organ studied in a CT scan of an adult receives around 15 millisieverts of radiation , compared with roughly 3.1 millisieverts of radiation exposure from natural sources each year. (
  • The new data are from an observational, multicenter, retrospective cohort analysis of more than 1,000 adult prevalent hemodialysis patients followed for up to two years at Baxter Renal Care Services clinics in Colombia. (
  • But in rare cases, illness can develop, and "this retrospective description … adds important insights to the body of knowledge about the similarities and differences between pediatric and adult infection," said Dr. Michael Grosso, chair of pediatrics at Huntington Hospital in Huntington, N.Y. (
  • Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. (
  • Observational, retrospective study on 20 adult patients. (
  • Results: 24.8% of adult patients in the clinic discontinued follow-up during the study period. (
  • Good quality published studies on tracheal intubation during adult in-hospital cardiac arrests are scarce. (
  • We will enroll 20 healthy adult volunteers and 20 adults with AD-HIES in an open-label, single-dose study to assess the immunological response to and the safety/tolerability of the NDV-3A vaccine. (
  • A retrospective chart review was undertaken on a cohort of high acuity (MTS1&2) non-traumatic adult patients. (
  • The fourth chapter will discuss the research findings of this study and present the aspects and themes observed through data collection of this case study's democratically-minded coaching style. (
  • The data was based on a larger study, the Longitudinal Examination to Gather Evidence of Neurodegenerative Disease (LEGEND). (
  • Amongst the highlights of data presented at ARVO, were data from the UK wide National Aflibercept Audit assessing the use of aflibercept in NHS clinical practice. (
  • Mr James Talks, Consultant in Ophthalmology, Royal Victoria Infirmary, Newcastle, presented data from the National Aflibercept Audit assessing the use of aflibercept in NHS clinical practice for treatment naïve wAMD patients. (
  • Researchers from Moorfields Eye Hospital, the leading provider of eye services in the UK and a world-class centre of excellence, presented data from a retrospective review of 250 consecutive patient records assessing the use of aflibercept in NHS clinical practice for treatment naïve wAMD. (
  • Firstly, the VAERS data used in the study include all adverse events that follow vaccination whether they were proven to have been caused by the vaccine or not. (
  • We present a retrospective cohort study of mortality data, obtained from the National Death Index (NDI), and clinical data for 517 infants born from 2011 to 2017 who died before 1 year of age in the United States. (
  • Baxter International Inc. ( NYSE:BAX ), a global innovator in renal care, announced today new data showing expanded hemodialysis (HDx) therapy enabled by the Theranova dialyzer may reduce cardiovascular events by 35% and hospitalization rates by 18% according to a new, large, multicenter, retrospective study of Colombian dialysis patients treated with long-term HDx compared to propensity-matched patients treated with High-Flux Hemodialysis. (
  • We reviewed clinical, biochemical, and molecular data. (
  • More natural history studies with comprehensive biochemical and molecular genetics data are needed for a robust base for the development of future therapy. (
  • The retrospective study included data reviewed from consecutive patients aged between 19 and 89 years who were admitted for cardiac surgery from August 2009 through June 2013. (
  • We have focused on the 3' end of the transcript in the design, using 3' sequencing data, confirmed poly-adenylated public sequence data and 3' focused probe design," said Tanney. (
  • This retrospective data analysis included all achalasia patients treated with POEM from January 2015 to August 2018 at Ordensklinikum Linz. (
  • This comparative study (i.e., three age groups, three measures) explores the distribution of retrospective and prospective autobiographical memory data across the lifespan, in particular the bump pattern of disproportionally higher recall of memories from the ages 10 to 30, as generally observed in older age groups, in conjunction with the well-known recency effect. (
  • The memory data patterns of the Life-line Interview Method (LIM, the measure of this study, were compared to the published data patterns of two other memory measures (i.e., the Time Line and Life event sorting task). (
  • Strategies We carried out a systemic review using released research which were determined through a computerized search of unique study using the Medline/PubMed data source, EMBASE, EBM Evaluations, Oct 2017 Proquest Google Scholar and Global Wellness reported from inception until 5. (
  • NIH experts can only estimate the number of rare diseases because there's not enough data to know how many patients have them, let alone how to study or treat them. (
  • All participants completed the study questionnaires and provided the required medical records and coronary angiograms and ancillary imaging data. (
  • A newly reported Swiss study provides us with what appear to be some sound comparative data on the relative merits of open radical prostatectomy (RP) and robot-assisted radical prostatectomy (RALP) at a center with a relatively low-volume caseload. (
  • A retrospective analysis of data from the Munich Cancer Registry in Germany now seems to confirm this argument. (
  • A further systematic review in 2006 of articles since 1990 found only 26 studies, 14 of which met the criteria for inclusion, which included up to six-month outcome data on the diet. (
  • What we fail to understand is RCTs are required only in selected situations in medical research (New drugs and interventions ) Meanwhile , we can do wonders with retrospective observational data. (
  • Despite these limitations, our study added long-term data of the Asian population to the existing literature of EBRT and LDR-BT in low- and intermediate-risk prostate cancer," the researchers said. (
  • To report retrospective data on the use of a single pdFVIII/VWF concentrate in primary and rescue ITI. (
  • however, they differed notably in their methodologies hindering data synthesis across studies. (
  • Richard Davies, CEO of BONESUPPORT, commented: "The start of this study is a key step in our strategy to build a compelling data set to support the prophylactic use of both CERAMENT G and CERAMENT V in patients undergoing hip and knee arthroplasty revisions. (
  • In addition to the updated data showing that only 20% of cancer drug indications approved through accelerated approval had shown improved overall survival in postmarketing studies, the researchers pointed to examples of the FDA approving drugs where no substantial benefit on meaningful endpoints was shown. (
  • This is a very long period (kudos for the organisers and authors) but the retrospective nature of the data collection can be criticised for all its inherent flaws. (
  • clinical experience 79 - 121415 and data from 2 small studies 813 and 1 retrospective case series 24 have been described. (
  • This study aimed to identify information derived from patients' social media data that can benefit clinicians and to develop a set of design implications, via a series of low-fidelity (lo-fi) prototypes, on how to deliver the information at the point of care. (
  • This exploratory co-design research confirmed that mental health attributes inferred from patients' social media data can be useful for clinicians, although it also revealed a gap between computational social media analyses and clinicians' expectations and conceptualizations of patients' mental health states. (
  • APSU data supports clinical and public health policy and surveillance for AFP contributes to Polio-Free certification by the WHO. (
  • Common symptoms reported from retrospective analyses of CTE confirmed cases include cognitive difficulties as well as mood and behavior symptoms like depression and impulsivity. (
  • In a sample of 592 participants from this study, cluster analyses identified five discrete groups of individuals based on their symptom profile. (
  • Studies on natural history or survival analyses of patients with pneumoconiosis have been constantly carried out during the past several decades [ 1 - 8 ]. (
  • Logistic regression and log-rank testing followed by Cox proportional hazard analyses were performed to investigate the predictors of the clinical success of palliative stenting and factors associated with RFS, respectively. (
  • All patients with biopsy-confirmed celiac disease receiving health care at our centre between April 2002 and December 2018 were identified. (
  • Our retrospective analysis comprises all patients with achalasia, who were treated from 2015 until 2018 with POEM. (
  • 1,3 The retrospective study conducted between 2011 and 2018 considered findings collected over nearly 15 years between 1998 and 2012. (
  • case studies, although a few words of advice are still offered with regard to presenting case study evidence. (
  • Building on the extensive and positive clinical evidence of the EQUIA restorative system, GC introduced in 2015 EQUIA Forte , the first glass hybrid, and offer an unprecedented option for long-term restorations. (
  • At Moorfields we are dedicated to building clinical evidence to ensure patients with ophthalmic conditions are treated effectively. (
  • As these populations age, mounting evidence is emerging that TBI is a risk factor for later neurological and neurodegenerative disease - such as Alzheimer's, Parkinson's and amyotrophic lateral sclerosis - with studies even indicating there is an increased risk of dementia after a single moderate-to-severe TBI. (
  • Many observational studies provided evidence that a diet rich in lycopene, espe- cially with tomatoes and tomato products, could reduce the risk of developing prostate carcinoma (4, 5). (
  • Evidence to support the clinical impact of pharmaceutical care programmes focusing on the resolution of potential drug-related problems is unclear. (
  • Six studies presented indirect evidence of the potential for SARS-CoV-2 transmission by children, 3 of which found prolonged virus shedding in stool. (
  • The authors conclude that evidence is limited and further seroprevalence studies are needed to establish whether children are less frequently infected or less infectious than adults. (
  • Background In contrast with most published evidence, studies from north-east Scotland suggest that GPs may be as good at treating skin cancers in primary care as secondary care specialists. (
  • Epidemiologic scenarios and clinical guidelines may consider the estimated risks, even though under-ascertainment of mild and asymptomatic cases should be considered in different age groups. (
  • was measured by three LY500307 independent measures including the 20-item Center for Epidemiologic Studies Depression Level (CES-D), the 20-item Spielberger State-Trait Panic Inventory-State LY500307 Subscale (STAI-S) [25] and the 13-item Functional Assessment of Malignancy Therapy-Fatigue (FACT-F) [26]. (
  • [13] , [14] Management of ectopic pregnancy is influenced by factors such as availability of laparoscopic skills and equipment, the clinical state of the patient, availability of transvaginal ultrasound scan and quantitative β-human chorionic gonadotropin, for early presentation. (
  • Further studies are needed to confirm the impact of earlier treatment initiation on patient outcome. (
  • Patient leadership in this is huge,' says study co-author Lee Aase, director of Mayo Clinic's Center for Social Media. (
  • Identifying and recruiting study participants with rare conditions such as SCAD can be a formidable challenge because no single medical center has adequate experience and/or patient volume. (
  • 1 , 2 Problems may relate to a patient-specific clinical question (e.g. (
  • The Emergency Department (ED) admission log was referenced to confirm patient mode of admission. (
  • Each case was then evaluated using the retrospective ACS criteria met and whether this number of criteria could predict likelihood of patient admission. (
  • Before applying dose escalation with proton beam therapy, prospective studies confirming lower normal tissue toxicity for proton therapy should be performed to ensure maximum patient safety. (
  • The two remaining unoperated cases presented with ileocolic intussusception, the etiology of which was in one case secondary to pancolitis in a patient undergoing transplantation for AML-M5, and in the other due to nodular lymphoid hyperplasia confirmed by biopsy Table IV. (
  • The purpose of this study is to obtain pretreatment predictors for margin positivity and ECE, to help optimize patient selection for TORS. (
  • Servicing providers should log in to eviCore using our Auth Request tool before services are performed to confirm that an authorization number for the patient, test and date range has been approved. (
  • If you are able to confirm that the patient has a vascular malformation, what treatment should be initiated? (
  • The clinical status of the patient will determine if emergent neurosurgical intervention is needed to address increased intracranial pressure (ICP). (
  • Lund, Sweden, 08:00 CEST 9 October 2017 - BONESUPPORT TM an emerging leader in innovative injectable bio-ceramic bone substitute products to treat bone voids caused by trauma, infection, disease or related surgery based on its unique CERAMENT® platformannounces that the first patient has been recruited in a study evaluating CERAMENT® G and CERAMENT® V in patients undergoing hip and knee arthroplasty revisions. (
  • Expanded access is a means by which manufacturers make investigational new drugs available, under certain circumstances, to treat a patient(s) with a serious disease or condition who cannot participate in a controlled clinical trial. (
  • Material and Method: Total of 54 American Society of Anesthesiologist Grade 1-2, Mallampati score 1 or 2, age between 18 to 65 patient planned to undergo nonopthalmic surgery will be included to study. (
  • The interim results of clinical studies show the suitability of EQUIA Forte as a long-term material to restore extended size Class II cavities. (
  • Results of the questionnaires were compared to a cohort study of primary LRTI's. (
  • Clinical results of distal anterior tibial tendon decompression. (
  • The aim of this research is to report on the history and clinical image of DTAT and present the clinical results of a simple surgical decompression of the tendon with local debridement and release of the distal extensor retinaculum. (
  • A further largescale, prospective study is necessary to investigate the several variables which can influence the results rate of TWOC. (
  • Results of the study found that the rate of DSWI dropped from 3.4% using standard dressings following cardiac surgery (17 of 504 cases studied) to 0 % with AQUACEL ® Ag SURGICAL (0 of 208 cases). (
  • The results of this study, in which six helicopter pilots flew a flight simulator and completed other tests throughout 40-hour periods of continuous wakefulness, showed that modafinil was moderately effective for sustaining both performance and alertness. (
  • The results of this comparative study confirm the universality of the bump for older adults, as well as the recency effect. (
  • According to results from a retrospective study, the presence of MRD after alloHCT also has prognostic value, and the significance of MRD differs depending on the type of conditioning regimen. (
  • Results A total of 106 406 patients (of whom 66,681 were on Tenofovir) were involved in these 31 studies with sample sizes ranging from 30 to 62,230. (
  • RESULTS: Radiographic and clinical examinations on the initial and long-term follow-up visits showed that root development continued and apices formed. (
  • He published a preliminary note (in German) on the promising results of the on-going clinical trial with racemic E-250 in depressed patients (Varga 1965). (
  • The results from a prospective cohort study with over 49,000 men over a period of 23 years indicate that a diet rich in lycopene could combat the development of aggressive prostate cancer with a fatal outcome, as well as the formation of new blood vessels (angiogenesis) that encourage cancer growth (6). (
  • Notably, the analysis showed no difference in terms of D mean , confirming the results from previous studies. (
  • 234 masses were confirmed RCC, 40 had nondiagnostic biopsies, and 8 had no biopsy results. (
  • Conclusion: Our study confirms results from international studies that weight loss through bariatric surgery can reduce the risk of developing Type 2 Diabetes Qatari obese patients. (
  • The results of the study suggest that post-surgery periods can be detrimental to the fate of fasting glucose and insulin levels and therefore compliance maybe of great importance to ensure success and sustainability of weight loss and diabetes prevention. (
  • The results from the study will be compared to a cohort of patients, at the same clinical centers, who were treated using current standard, of care. (
  • The aim of the larger study which we are now conducting is to confirm these promising initial results in a larger cohort of patients and compare the results to a retrospective control. (
  • Our results demonstrate that serum β2M is correlated closely with the clinical stage, Gleason grade, PSA, distant metastasis and therapy efficacy in patients with PCa. (
  • Out of a total number of 111 patients whom an EEG test was requested and epilepsy was highly suspected from clinical presentation, only 14 patients (12.6%),presented with epileptiform discharge on their EEG results. (
  • This exploratory study confirmed the effective dose of SGX942 in HNC patients with severe OM, and the results support further clinical research on its effectiveness in OM, the investigators said. (
  • A retrospective chart review was performed. (
  • This study established a lower prevalence of ectopic pregnancy and zero mortality, with the introduction of free maternity service, compared to an earlier study. (
  • Background: Several small studies on patients with COVID-19 and haematological malignancies are available showing a high mortality in this population. (
  • When compared with the general Italian population with COVID-19, the standardised mortality ratio was 2·04 (95% CI 1·77-2·34) in our whole study cohort and 3·72 (2·86-4·64) in individuals younger than 70 years. (
  • This study demonstrated a high incidence of competing mortality in older patients with comorbidities. (
  • The aim of this study was to evaluate factors associated with increased risk of mortality from pneumonia among patients with pneumoconiosis. (
  • To date, there have been several studies concerning various factors associated with pneumonia-mortality among patients with underlying pulmonary conditions such as chronic obstructive pulmonary disease (COPD) or interstitial lung disease [ 10 - 13 ]. (
  • Owing to insufficient knowledge, when conducting an advisory investigation regarding causal relationship between mortality from pneumonia and pneumoconiosis, references have been commonly made to studies based on other chronic respiratory diseases mainly with COPD. (
  • This study evaluated the prognostic impact of AKI duration on in-hospital mortality in elder patients. (
  • The study cited to support this claim does not account for potential risk factors which may contribute to spontaneous abortion, nor does it compare its findings to the baseline risk for spontaneous abortion in unvaccinated women. (
  • The aim of this study is to assess the accuracy of TVUS in predicting DIE by comparing gold standard laparoscopic findings. (
  • As our study findings show, none of our patients treated with AQUACEL ® Ag SURGICAL cover dressing experienced a DSWI. (
  • Larger samples size and longer follow-up period is required to confirm these findings. (
  • In the clinical studies, findings of the association or predictive relations were not consistent. (
  • Figures and tables range from one to three and should be limited to those most pertinent to the study without duplicating findings in the text. (
  • These findings were consistent with the phase 1 clinical study. (
  • Obesity has long been noted as a risk factor for adults with COVID-19, "so it was interesting that many of the hospitalized patients in this study had obesity and/or overweight," said researchers led by Dr. Philip Zachariah, a pediatrician at Columbia University Irving Medical Center in New York City. (
  • In a retrospective examine, researchers evaluated the consequences of CBD treatment in 72 adults with either anxiety or sleep problems. (
  • A team of clinical researchers and human-computer interaction (HCI) researchers conducted a long-term co-design activity for over 6 months. (
  • 8. Al-Hussaini A, Sulaiman N, Al-Zahrani M, Alenizi A, El Haj I. High prevalence of celiac disease among Saudi children with type 1 diabetes: a prospective cross-sectional study. (
  • Due to the reported increase in prevalence in several studies across Nigeria in the last few decades, periodic review of management is of relevance for institutional comparison. (
  • The aim of the study was to determine the prevalence, risk factors and management of ectopic pregnancy in Eku Baptist Government Hospital, a secondary health facility providing free maternity services, and compare these with an earlier study in the same facility and other parts of Nigeria. (
  • This study adds knowledge about the impact of pharmaceutical care programmes focusing on the resolution of potential drug-related problems, and has a favourable clinical impact, reducing the number and prevalence of DNO. (
  • The studies had differing definitions of kidney dysfunction and were of variable study design quality. (
  • Study design: A retrospective analysis was conducted on post-bariatric patients at the department of bariatric and metabolic surgery at Hamad General Hospital. (
  • Limitations of the current study include its retrospective design, relatively short follow-up, and insufficient between-arm matching regarding known prognostic clinical and pathological factors. (
  • Design and setting A retrospective analysis of reports from GPs in Lothian, Fife, and Tayside regions. (
  • Much of the information we know regarding hypoxic-ischemic encephalopathy (HIE) comes from studies done on infants that are 36 weeks or older (babies that are at term or near term). (
  • This is exceptionally important, as studies show that 63% of infants that do not get hypothermia therapy either die or show signs of disability. (
  • The aim of this pilot study was to evaluate S100A12, a marker of innate immune activation, in mothers with or without HCA and in their infants. (
  • It is encouraging to see that large centres from across the UK have a continued enthusiasm to audit the use of EYLEA in NHS clinical practice. (
  • According to Tanney, this FFPE focus is "very important, particularly in oncology," and allows Almac to carry out retrospective analysis and to "discover biomarkers that can be developed into tests which do not require changes to current clinical practice. (
  • A great place to identify research ideas is from your own clinical practice, such as when you encounter problems but cannot find solutions in the scientific literature. (
  • Background: The use of bariatric surgeries such as Gastric Bypass and Sleeve Gastrectomy in managing obesity and associated diseases such as type 2 diabetes mellitus (T2DM) has been induced in clinical practice. (
  • The prospective, multi-centre German TAVI registry was initiated in 2009 to evaluate indication, intervention, and clinical outcome and assess quality of life after TAVI in routine clinical practice. (
  • An interprofessional clinical toxicology advanced pharmacy practice experience. (
  • The purpose of this study is to determine if using a tablet computer, which is a very small, easy-to-carry computer, to practice thinking exercises at home will help improve your attention, memory, and problem solving abilities. (
  • The study will establish the efficacy of using home practice on a tablet to increase the number of computer cognitive practice exercises completed by clients. (
  • Failed first carpometacarpal joint replacement can be salvaged by ligament reconstruction with tendon interposition, providing an acceptable functional outcome in 79% of cases studied. (
  • This study compares the ability of the most commonly used systems (ANRS, Rega, and Stanford's HIVdb) to predict virological outcome at 12, 24, and 48 weeks. (
  • Formulate study hypotheses and select related outcome measures. (
  • The relationship between the mean absorbed dose delivered to the tumour and the outcome in liver metastases from colorectal cancer patients treated with radioembolization has already been presented in several studies. (
  • The subjects were divided into two groups by clinical outcome of pneumonia, the deceased group and the survival group. (
  • This study aimed to evaluate the predictive role of early post-cooling brain magnetic resonance for developmental outcome in newborns with hypoxic-ischemic encephalopathy. (
  • This study aimed to evaluate, in a common sample, the prognostic role of main structural, diffusivity, and spectroscopic indices at brain MRI in the early stages after therapeutic hypothermia for the prediction of developmental outcome. (
  • The aim of the study is to show an improved clinical outcome and a lower infection rate for the CERAMENT G or CERAMENT V group compared to the retrospective control cohort where neither CERAMENT G or CERAMENT V were used. (
  • We have already conducted a pilot study that showed a beneficial outcome from using CERAMENT G and CERAMENT V in a small series of patients undergoing two-stage knee and hip arthroplasty revisions. (
  • The aim of this study was to assess clinically if at all, there is any change in the symptoms of a person post an isolated septal surgery without dealing with the external contour and cosmetic appeal. (
  • The preoperative evaluation included a high-resolution manometry (Chicago classification), EGD (esophagogastroduodenoscopy), video cinematography, and an assessment of the patients' clinical symptoms (Eckardt score) [1,2]. (
  • Follow-up investigations at 6 weeks after POEM consisted of a control gastroscopy and an assessment of clinical symptoms. (
  • The study describes differences in the causes, mechanisms, signs and symptoms of brain injuries in babies of different gestational ages, and points out similarities and differences in babies that are full-term, more mature preterm babies, and extremely preterm babies. (
  • Future studies will benefit from the measurement of BPD symptoms in very early adolescence, and concurrent measurement of NSSI as well as other forms of suicidal behaviours across adolescence. (
  • Early Phase Study Comparing the Effectiveness of a Dairy Product With the Reference Treatment Aequasyal® on Dry Mouth Symptoms in Patients Suffering From Xerostomia Caused by Psychotropic Medications. (
  • Considerable number of patients with pneumoconiosis die from pneumonia in Korea, yet, hardly any study was carried out to assess the risk factors associated with their deaths. (
  • In this study, the investigators sought to assess the intermediate- and long-term safety and efficacy of percutaneous CA for renal masses at a single institution. (
  • This study indicates either a need for rigorous training of endoscopists and/or need for AI review of endoscopy. (
  • Furthermore, by reducing the risk of influenza infection, the flu shot may actually prevent congenital abnormalities associated with maternal respiratory infection, as shown by a review and meta-analysis of more than 20 studies [5] . (
  • The Feature Paper can be either an original research article, a substantial novel research study that often involves several techniques or approaches, or a comprehensive review paper with concise and precise updates on the latest progress in the field that systematically reviews the most exciting advances in scientific literature. (
  • Method: We conducted a retrospective chart review of 28 subjects from 24 families with molecularly confirmed 6-pyruvoyltetrahydropterin synthase deficiency from six centers in three Arab countries. (
  • Conclusions Our review identified studies in Africans reporting statistically significant renal function decline associated with TDF use but the clinical significance of this effect was not enough to contraindicate its continued use in ART regimens. (
  • In 2000 a systematic review reported on studies evaluating the KD and its use in childhood epilepsy. (
  • 7 Of note was the fact that only 11 studies fulfilled the criteria for the review. (
  • A retrospective chart review over a period of 15 years was compiled by identifying 14 patients who had been exposed to cyanide from sources other than from fire or smoke (i.e., ingestion or inhalation). (
  • An 11-year retrospective review of cyproheptadine use in serotonin syndrome cases reported to the California Poison Control System. (
  • conducted a rapid review of 16 studies investigating the role of children in the transmission of SARS-CoV-2. (
  • Case studies have five main objectives, to have employees ask questions that extract key information, diagnose actual cases, define all the different issues involved in the case, make decisions, and formulate principles for handling future situations (Stolovitch & Keeps, 1991, p. 46). (
  • Previous study has reported several COVID-19 cases with conjunctivitis. (
  • A serologic survey conducted over a 700-km2 area in stables with and without apparent clinical cases confirmed a wider spread of the infection, with an overall seroprevalence rate of 38% in the affected area. (
  • International studies describing COVID-19 in children have shown low proportions of paediatric cases and generally a mild clinical course. (
  • Our study identified a very low rate of SARS-CoV-2 positive cases in children presenting to a tertiary ED or RIC, none of whom were admitted to hospital. (
  • We analyzed 54 cases of cytologically confirmed gastric LMC at four institutions from 1994 to 2007. (
  • Information on community-based confirmed and probable cases and their contacts was centralized on the website. (
  • A retrospective study of cases of ectopic pregnancy managed at Eku Baptist Government Hospital in a 5-year period: 1 January 2013-31 December 2017. (
  • However, the long-term effects of radiation on the developing nervous system are not well known, and several studies have shown some perioperative complications and a few cases of radiation-induced malignancy. (
  • According to research published in Journal of Clinical and Experimental Dentistry, short-term (acute) GVHD occurs in 50 to 70 percent of stem cell transplant cases and longer-term (chronic) GVHD is seen in 30 to 50 percent of cases. (
  • Social media and online networking proved to be a valuable tool for recruiting participants to a pilot study on a rare heart disease last summer at the Mayo Clinic. (
  • Designing research protocols to study rare diseases and then recruiting enough patients to participate is extremely difficult for busy physicians, but patients with rare diseases are highly motivated to see research happen. (
  • Dose heterogeneity was compared voxel-to-voxel using the quality-volume histograms, subsequently used to demonstrate how it could be used to identify potential clinical parameters that are responsible for quantitative discrepancies between predictive and post-treatment dosimetry. (
  • They did stress that "the small sample size of this descriptive study may additionally limit generalizability" to a broader population of children with COVID-19. (
  • A retrospective descriptive study was conducted on all patients aged over 16 years who were diagnosed with intestinal invagination, both preoperatively and postoperatively, between January and January in any of the clinical departments at Morales Meseguer University Hospital Murcia, Spaina center serving a population of aroundinhabitants. (
  • This new study published in The Lancet Neurology suggests that the new subtype is characterized by neuronal loss - damage or death of neurons, but no demyelination of the brain's white matter. (
  • The study is a simple retrospective analysis of 111 consecutive EEG requested to the department of Neurology at DGMH from psychiatric unit at DGMH. (
  • We conducted a single institution retrospective study of 34 consecutive patients with primary oropharyngeal cancer who underwent TORS. (
  • I confirm that any such study reported in the manuscript has been registered and the trial registration ID is provided (note: if posting a prospective study registered retrospectively, please provide a statement in the trial ID field explaining why the study was not registered in advance). (
  • A further largescale, prospective study is essential to investigate the numerous variables that will influence the accomplishment price of TWOC. (
  • This study aimed to evaluate the effect of biofeedback therapy in children with chronic functional constipation unresponsive to medical and conventional treatments. (
  • The present study was done with the objective of studying the socio-demographic and clinical profile of deceased patients with coronavirus disease. (
  • And we compared the [18F]FDG PET response assessment to RECIST response assessment and survival.A total of 223 stage IV non-small cell lung cancer (NSCLC) patients were included in a phase II study (NCT01171170) randomizing between PCB treatment with or without NTG patches. (
  • Patients with metastatic or unresectable EGFR- mutant (i.e., exon 19 deletions or L858R mutations) NSCLC were treated with amivantamab plus lazertinib in the phase I CHRYSALIS study [4]. (
  • New studies assessing amivantamab plus lazertinib have been started, including the phase III MARIPOSA trial (NCT04487080) that is comparing frontline use of the combination with osimertinib. (
  • This is a single-centre, prospective, randomised controlled, phase II clinical trial to compare photon to proton radiotherapy up to 66 Gy (RBE) with concomitant standard chemotherapy in patients with locally advanced-stage NSCLC. (
  • In Phase 1 and Phase 2 studies in healthy volunteers (150 receiving vaccine), the safety profile of this vaccine is very reassuring as the vaccine elicits a strong antibody response after a single dose in all vaccinees as well as a Th1 and/or Th17 response in the majority of vaccinees. (
  • This phase II trial studies how well everolimus and letrozole with or without ribociclib work in treating participants with endometrial cancer that has spread to other areas of the body or has come back. (
  • A similar nonlinear dose response curve was observed in the clinical and preclinical phase 1 studies. (
  • This aim of this observational study is to investigate how the recently introduced National Early Warning Score (ViEWS) applied in the prehospital setting (Ph-ViEWS) compares with the Manchester Triage System (MTS) used in most Emergency Departments (ED) in Ireland. (
  • The aim of this observational study is to investigate how prehospital applied ViEWS (Ph-ViEWS) compares with MTS. (
  • It is therefore important to look at this also, especially if you have such a huge cohort of patients studied over a period of over a decade. (
  • Managing studies in all major geographies, we have established solid working relationships with the world's leading investigators. (
  • Much of what the investigators saw confirmed previous experience," Grosso said. (
  • In this study, the investigators aimed to compare the effects of direct laryngoscopic and fiberoptic endotracheal intubation on intraocular pressure. (
  • 1 APSU study protocols and case definitions are developed with collaborating study investigators who provide clinical expertise for each condition listed. (
  • Formulate primary and secondary study objectives. (
  • SECONDARY OBJECTIVES: I. To determine clinical benefit and the median duration of progression-free survival (PFS) and overall survival (OS) in patients with advanced or recurrent endometrial carcinoma treated with ribociclib (LEE011), everolimus and letrozole versus everolimus and letrozole alone. (
  • Fourteen participated and were invited for a clinical examination and asked to fill out two questionnaires. (
  • Diagnoses were confirmed by histopathological examination. (
  • Detailed clinical history, physical examination and routine investigation of all patients including ADA estimation by Galanti And Giusti method was done. (
  • Thorough clinical and radiographic examination for the ridge area to be treated will be done. (
  • There was no fatality in this study amongst participants. (
  • The median age of the participants across all of the scholarly studies ranged from 34 to 43? (
  • The study landed 18 participants in less than a week, six more than could participate in this pilot of 12 patients. (
  • Participants will have 6-7 study visits over 6-7 months. (
  • After completion of study treatment, participants are followed up at 30 days and then every 3 months. (
  • Retrospective, observational, investigator-led multi-center study. (
  • The investigator-led study is an open-label, prospective cohort, observational clinical trial designed to evaluate the effectiveness and safety of CERAMENT G or CERAMENT V when used to fill bone defects in the tibia and/or femur shaft and/or acetabulum in patients scheduled for two-stage hip or knee prosthesis re-implantation for periprosthetic joint infections (PJIs). (
  • The study found that acute injuries are significantly thicker than chronic injuries, and only acute symptomatic thicknesses are significantly different from their asymptomatic thickness counterparts. (
  • The purpose of this study is to investigate the effectiveness of a hip arthroplasty for chronic pain, caused by a unilateral primary Coxartrhrose, regarding the cognitive performance. (
  • Studies have shown that cognitive performance, especially in the elderly is limited due to chronic pain. (
  • It complements a suite of Disease-Specific Arrays for breast, ovarian, colorectal, lung, and prostate cancer studies Almac has introduced in recent years. (
  • Low-dose-rate brachytherapy (LDR-BT) provides a better biochemical failure-free survival (bFFS) rate than external beam radiation therapy (EBRT) in Asian men with intermediate-risk prostate cancer, according to a recent Singapore study. (
  • The present retrospective study included 642 men (median age 69 years) with biopsy-proven low- and intermediate-risk prostate cancer. (
  • Prostate cancer was also examined because testosterone therapy has historically been considered a risk factor for developing prostate cancer, even though recent studies have disproved this (see comment below). (
  • Survival in these two studies was 34 of 61 (56%) for one study, and 30 of 72 (42%) for the second. (
  • We aimed to identify factors associated with clinical success and the reintervention-free survival (RFS) after palliative stenting. (
  • Survival and cardiovascular events in men treated with testosterone therapy: an intention-to-treat observational cohort study. (
  • This study attempted to determine whether tracheal intubation during in-hospital cardiac arrest was associated with improved survival rates at point of hospital discharge. (
  • Just published, on JACC (Journals of the American College of Cardiology), a study involving several Italian centers on a population of patients with drug-induced type 1 pattern, analyzed restrospectively on a medium/long term follow up. (
  • The study will be conducted at a small number of leading centers in the United States and Europe and will inform our discussions with regulators. (
  • Professor Carlo Romanò is the Principal Investigator for the study, which will take place at 6 different clinical centers in Italy and is expected to recruit approximately 135 patients. (
  • GREENSBORO, NC (November 3, 2014) - A new retrospective study has found that use of AQUACEL ® Ag SURGICAL cover dressing resulted in a significant reduction in the rate of deep sternal wound infection (DSWI) in patients who undergo cardiac surgery. (
  • Deep sternal wound infection is a major healthcare threat as well as a serious economic concern," said Scott Schubach, MD, author of the study, Chairman of the Department of Thoracic and Cardiovascular Surgery at Winthrop Hospital, Mineola, NY, and Assistant Professor of Clinical Surgery at Stony Brook School of Medicine, Stony Brook, NY. (
  • Similarly, studies show that bacterial co-infection was common in patients suffering from H1N1 influenza during the 2009/10 outbreak and caused between 29% and 55% of all H1N1 deaths. (
  • bacterial co-infection was confirmed in eleven patients. (
  • One endpoint of the study will be the rate of PJIs according to the Musculoskeletal Infection Society (MSIS) criteria during the one year follow-up. (
  • Suspected or confirmed infection should be treated with antibiotics commenced before use of hyaluronidase. (