Ribavirin: A nucleoside antimetabolite antiviral agent that blocks nucleic acid synthesis and is used against both RNA and DNA viruses.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.Interferon-alpha: One of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells. In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES, and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways.Polyethylene Glycols: Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.Hepatitis C, Chronic: INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.Ribonucleosides: Nucleosides in which the purine or pyrimidine base is combined with ribose. (Dorland, 28th ed)Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Hepacivirus: A genus of FLAVIVIRIDAE causing parenterally-transmitted HEPATITIS C which is associated with transfusions and drug abuse. Hepatitis C virus is the type species.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Hepatitis C: INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Viral Load: The quantity of measurable virus in a body fluid. Change in viral load, measured in plasma, is sometimes used as a SURROGATE MARKER in disease progression.Amantadine: An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Interferons: Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.IMP Dehydrogenase: An enzyme that catalyzes the dehydrogenation of inosine 5'-phosphate to xanthosine 5'-phosphate in the presence of NAD. EC 1.1.1.205.Hemorrhagic Fever, Crimean: A severe, often fatal disease in humans caused by the Crimean-Congo hemorrhagic fever virus (HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO).Guanosine: A purine nucleoside that has guanine linked by its N9 nitrogen to the C1 carbon of ribose. It is a component of ribonucleic acid and its nucleotides play important roles in metabolism. (From Dorland, 28th ed)Aerosols: Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.Equilibrative Nucleoside Transporter 1: A subtype of equilibrative nucleoside transporter proteins that is sensitive to inhibition by 4-nitrobenzylthioinosine.Alanine Transaminase: An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Recurrence: The return of a sign, symptom, or disease after a remission.Virus Replication: The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.Hemorrhagic Fever Virus, Crimean-Congo: A species of NAIROVIRUS of the family BUNYAVIRIDAE. It is primarily transmitted by ticks and causes a severe, often fatal disease in humans.Interleukins: Soluble factors which stimulate growth-related activities of leukocytes as well as other cell types. They enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli.Respirovirus Infections: Infections with viruses of the genus RESPIROVIRUS, family PARAMYXOVIRIDAE. Host cell infection occurs by adsorption, via HEMAGGLUTININ, to the cell surface.Coinfection: Simultaneous infection of a host organism by two or more pathogens. In virology, coinfection commonly refers to simultaneous infection of a single cell by two or more different viruses.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Serial Passage: Inoculation of a series of animals or in vitro tissue with an infectious bacterium or virus, as in VIRULENCE studies and the development of vaccines.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.Hemorrhagic Fever, American: Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).Drug Resistance, Viral: The ability of viruses to resist or to become tolerant to chemotherapeutic agents or antiviral agents. This resistance is acquired through gene mutation.Arenavirus: The only genus in the family ARENAVIRIDAE. It contains two groups ARENAVIRUSES, OLD WORLD and ARENAVIRUSES, NEW WORLD, which are distinguished by antigenic relationships and geographic distribution.Uridine Monophosphate: 5'-Uridylic acid. A uracil nucleotide containing one phosphate group esterified to the sugar moiety in the 2', 3' or 5' position.BooksLibrarians: Specialists in the management of a library or the services rendered by a library, bringing professional skills to administration, organization of material and personnel, interpretation of bibliothecal rules, the development and maintenance of the library's collection, and the provision of information services.Fishes: A group of cold-blooded, aquatic vertebrates having gills, fins, a cartilaginous or bony endoskeleton, and elongated bodies covered with scales.Libraries, MedicalHIV Infections: Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).Anti-HIV Agents: Agents used to treat AIDS and/or stop the spread of the HIV infection. These do not include drugs used to treat symptoms or opportunistic infections associated with AIDS.Antiretroviral Therapy, Highly Active: Drug regimens, for patients with HIV INFECTIONS, that aggressively suppress HIV replication. The regimens usually involve administration of three or more different drugs including a protease inhibitor.CD4 Lymphocyte Count: The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.HIV-1: The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.Metabolic Diseases: Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)Chikungunya virus: A species of ALPHAVIRUS causing an acute dengue-like fever.Alphavirus Infections: Virus diseases caused by members of the ALPHAVIRUS genus of the family TOGAVIRIDAE.Coronavirus: A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.Middle East: The region of southwest Asia and northeastern Africa usually considered as extending from Libya on the west to Afghanistan on the east. (From Webster's New Geographical Dictionary, 1988)Coronavirus Infections: Virus diseases caused by the CORONAVIRUS genus. Some specifics include transmissible enteritis of turkeys (ENTERITIS, TRANSMISSIBLE, OF TURKEYS); FELINE INFECTIOUS PERITONITIS; and transmissible gastroenteritis of swine (GASTROENTERITIS, TRANSMISSIBLE, OF SWINE).Coronaviridae Infections: Virus diseases caused by CORONAVIRIDAE.Camels: Hoofed mammals with four legs, a big-lipped snout, and a humped back belonging to the family Camelidae.
Reviews of existing small studies suggest that ribavirin can be considered effective in immunocompromised people who have ... "Maternal and Fetal Outcomes in Pregnant Women with Acute Hepatitis E Virus Infection". Annals of Internal Medicine. 147 (1): ... Concomitant conditions *Diabetes mellitus. *Systemic lupus erythematosus. *Thyroid disorders. *Maternal death. *Sexual activity ...
birth defects and/or fetal death may occur with ribavirin use. obtain a negative pregnancy test immediately before ribavirin ... concomitant ribavirin or peginterferon alfa in women who are or may become pregnant and in men with pregnant female partners. ... Advise patient drug must not be used alone and must be used in combination with ribavirin or in combination with peginterferon ... Ribavirin. Peginterferon. Telaprevir. Boceprevir Sovaldi (Sofosbuvir). Side Effects/Adverse Reactions. Drug Interactions. may ...
144 Concomitant use of ddI and ribavirin in HIV/HCV-coinfected patients may represent a risk factor for lactic acidosis as well ... and cases of acidosis with maternal and fetal deaths have been reported.142,143 Patients with preexisting liver disease and ... Evidence suggesting mitochondrial toxicity in HIV/HCV co-infected patients receiving ribavirin and didanosine. 10th Conference ... Patients with lactic acidemia tended to have concomitant lipid abnormalities, hyperglycemia, and lipoatrophy. However, chronic ...
Embryo fetal damage due to combination of Hepcvel with ribavirin Fetal damage condition is due to the concomitant use of ... Fetal damage condition is due to the concomitant use of Hepcvel with ribavirin during pregnancy period. Fatigue, Nausea, ... Hepcvel is probably safe to use and its pregnancy category is B While concomitant with ribavirin then the pregnancy category is ... Hepcvel is contraindicated to pregnancy condition due to concomitant use with ribavirin. Some anaphylactic reactions are ...
Embryo fetal damage due to combination of Velasof with ribavirin Fetal damage condition is due to the concomitant use of ... Velasof is probably safe to use and its pregnancy category is B While concomitant with ribavirin then the pregnancy category is ... Velasof is contraindicated to pregnancy condition due to concomitant use with ribavirin. Some anaphylactic reactions are ... Loss of activity occurs during concomitant use of Velasof with P-gp inducers. The concurrent use of Velasof with P-gp inducers ...
Sofovir-Daclahep is combined with ribavirin causes some fetal damage. Avoid this concomitant during pregnancy ... Dosage recommendation of Ribavirin: Patient with HCV related genotype I or III: The recommended dose of ribavirin is 600mg ... Based on the weight of the HCV suspected patients; At least 75kg: 1200mg of ribavirin should be taken Below 75kg: 1000mg should ... Usually Daclatasvir is not used as monotherapy; it must be concomitant with sofosbuvir for potent anti-viral activity. Sofovir- ...
In an open system, 11 placentas were perfused on both the maternal and the fetal side immediately after delivery. The injuries ... High mortality reported in men undergoing transurethral prostatectomy may be due to concomitant medical problems rather than ... sovaldi and ribavirin reviews of london. The anti-oxidants N-acetyl-l-cysteine (NAC) and (-)-epigallocatechin-3-gallate (EGCG) ... Ribavirin, Rebetol, Copegus, Alfater, Beclabuvir, Boceprevir, Daclatasvir, Daklinza, Dasabuvir, Elbasvir, Filibuvir, Hepcinat, ...
If relevant, fetal heart tones may be reassuring; however, no specific emergent intervention or procedure is indicated in the ... Antibiotics are warranted if concomitant bacterial infection is suspected.. Currently, there is no good animal model for ... In vitro, multiple antiviral agents have activity against MERS, including interferon, ribavirin, protease inhibitors, ... Anatomical, animal, and cellular evidence for Zika-induced pathogenesis of fetal microcephaly. Brain Dev. 2016;39(4):294-297. ( ...
TLN mediates the uptake of microbeads concomitant with actin and PIP2 recruitment, indicating a phagocytic origin of TLN ... the luminal surface of human fetal intestine and bronchus and areas of putative endodermal differentiation within germ-cell ... ribavirin pregnancy registry epilepsy. *peginterferon alfa-2b or alfa-2a with ribavirin for treatment of hepatitis c infection ... Ribavirin, Rebetol, Copegus, Alfater, Beclabuvir, Boceprevir, Daclatasvir, Daklinza, Dasabuvir, Elbasvir, Filibuvir, Hepcinat, ...
Avoid concomitant stavudine, doxorubicin, nucleoside analogues (eg, ribavirin). Increased hematologic toxicity with ganciclovir ... Prevention of maternal-fetal HIV-1 transmission.. Adult:. ≥18yrs: 300mg twice daily. Renal impairment (CrCl ... Monitor for treatment-associated toxicities (eg, hepatic decompensation) with interferon alpha with or without ribavirin. ... interferon alpha, ribavirin, other bone marrow suppressants or cytotoxic drugs. ...
Use with Ribavirin. *The use of ribavirin for hepatitis C in patients receiving azathioprine has been reported to induce severe ... Some of the patients were treated with azathioprine tablets as monotherapy and some had received concomitant treatment with a ... Azathioprine tablets can cause fetal harm when administered to a pregnant woman. Azathioprine tablets should not be given ... Ribavirin is known to inhibit IMDH, thereby leading to accumulation of an azathioprine metabolite, 6-methylthioionosine ...
Avoid concomitant stavudine, doxorubicin, nucleoside analogues (eg, ribavirin). Increased hematologic toxicity with ganciclovir ... Prevention of maternal-fetal HIV-1 transmission.. Adult:. ≥18yrs: 300mg twice daily. Renal impairment (CrCl ... Monitor for treatment-associated toxicities (eg, hepatic decompensation) with interferon alpha with or without ribavirin. ... interferon alpha, ribavirin, other bone marrow suppressants or cytotoxic drugs. ...
Concomitant etravirine without atazanavir/ritonavir, darunavir/ritonavir, or lopinavir/ritonavir: not recommended. Concomitant ... Embryo-fetal toxicity: increased risk of neural tube defects (avoid use at time of conception through 1st trimester). Pregnancy ... Monitor for toxicities (eg, hepatic decompensation) with IFN-α ± ribavirin (consider reducing dose or discontinue one or both ... Avoid concomitant sorbitol-containing products. Concomitant cation-containing antacids, laxatives, sucralfate, buffered drugs, ...
Use with Ribavirin. The use of ribavirin for hepatitis C in patients receiving azathioprine has been reported to induce severe ... Azathioprine can cause fetal harm when administered to a pregnant woman. Azathioprine should not be given during pregnancy ... Concomitant use of azathioprine with febuxostat is not recommended. It is recommended that a further dose reduction or ... Ribavirin is known to inhibit IMDH, thereby leading to accumulation of an azathioprine metabolite, 6-methylthioionosine ...
pegylated interferon vs interferon ribavirin. We conclude that higher levels of foetal haemoglobin positively influence the ... Preliminary ophthalmologic treatment, concomitant manifestations and an illustration provided by the growing number of patients ... interferon ribavirin and telaprevir clinical trials. Here a case of sirenomelia born of a 5th gravida mother is reported. In ... Ribavirin, Rebetol, Copegus, Alfater, Beclabuvir, Boceprevir, Daclatasvir, Daklinza, Dasabuvir, Elbasvir, Filibuvir, Hepcinat, ...
Ribavirin Pregnancy Registry A Ribavirin Pregnancy Registry has been established to monitor maternal-fetal outcomes of ... Azathioprine: Concomitant use of azathioprine with ribavirin has been reported to induce severe pancytopenia and may increase ... Birth defects and fetal death with ribavirin: Do not use in pregnancy and for 6 months after treatment. Patients must have a ... COPEGUS (ribavirin) is contraindicated in:. *Women who are pregnant. COPEGUS may cause fetal harm when administered to a ...
When used in conjunction with ribavirin, consider that ribavirin may cause fetal toxicity and/or death.349 377 Extreme care ... Amiodarone: Concomitant use with ledipasvir/sofosbuvir not recommended;1 if concomitant use required, patient counseling and ... Use weight-based ribavirin dosage (1 g daily for patients ≥75 kg or 1.2 g daily for those ≥75 kg); give ribavirin daily dosage ... Use weight-based ribavirin dosage (1 g daily for patients ,75 kg or 1.2 g daily for those ≥75 kg); give ribavirin daily dosage ...
... concomitant use of stavudine with doxorubicin should be undertaken with caution.Ribavirin: In vitro data indicate ribavirin ... The concentration in fetal tissue was approximately one-half the concentration in maternal plasma. Animal reproduction studies ... The clinical significance of the interaction with stavudine is unknown; therefore, concomitant use of stavudine with ribavirin ... Use With Interferon And Ribavirin-Based Regimens. In vitro studies have shown ribavirin can reduce the phosphorylation of ...
Maternal-Fetal HIV Transmission:. RETROVIR is also indicated for the prevention of maternal-fetal HIV transmission as part of a ... Ribavirin: In vitro data indicate ribavirin reduces phosphorylation of lamivudine, stavudine, and zidovudine. However, no ... Doxorubicin: Concomitant use of zidovudine with doxorubicin should be avoided since an antagonistic relationship has been ... Use With Interferon- and Ribavirin-Based Regimens:. In vitro studies have shown ribavirin can reduce the phosphorylation of ...
Utilization of ribavirin with Myhep All Fetal mischief condition is a result of the orderly usage of Myhep All with ribavirin ... The concomitant use of Myhep All with st Johns wort causes loss of activity of Myhep All due to decreased concentration of ... Myhep All pregnancy category B Myhep All with ribavirin pregnancy category X Ribavirin is contraindicated to pregnancy period. ... The dose of ribavirin should be calculated for the patients Patient with Myhep All tablets dosage adjustment should not be ...
2010) Concomitant Nevirapine Therapy is Associated with Higher Efficacy of Pegylated Interferon Plus Ribavirin among HIV/ ... 2008) Profiling of Phosphorylated Proteins in Human Fetal Liver. J Proteomics Bioinform 1: 437-457. ... Embryonic stem cells have the Ethical issues and concerns like Embryo destruction and fetal injury to extract the embryonic ...
The clinical significance of the interaction with stavudine is unknown; therefore, concomitant use of stavudine with ribavirin ... The concentration in fetal tissue was approximately one-half the concentration in maternal plasma. Animal reproduction studies ... Use with Interferon and Ribavirin-Based Regimens. In vitro studies have shown ribavirin can reduce the phosphorylation of ... Ribavirin: In vitro data indicate ribavirin reduces phosphorylation of lamivudine, stavudine, and zidovudine. ...
In combination with ribavirin causes fetal harm. Storage Conditions for MyHep All. You should store your MyHep All below 25°C ... Bradycardia caused by concomitant with amiodarone. Special Precautions And Related Warnings Of MyHep All MyHep All Tablet is ... It may sometimes be used with another antiviral medication (ribavirin).. How MyHep All working. MyHep All Tablet is a ... of concentration of Velpatasvir Myhep All combination with amiodarone causes serious bradycardia symptomatically Concomitant of ...
  • Adequate and well-controlled trials have not been performed in humans, but increased spontaneous abortions and major human fetal abnormalities have occurred when pregnant women received other retinoids. (pdr.net)
  • Deficiencies of these vitamins may lead to fetal neural tube defects, eye abnormalities, and intracerebral hemorrhage . (bloomassociation.org)
  • Most epidemiologic studies examining fetal abnormalities after exposure to antihypertensive use in the first trimester have not distinguished drugs affecting the renin-angiotensin system from other antihypertensive agents. (vacker.info)
  • Ribavirin alone appears to have no significant beneficial effect on virological response and liver morbidity in chronic hepatitis C as compared to placebo or no intervention, but may improve biochemical and histological response transiently. (essentialevidenceplus.com)
  • Ribavirin has been an integral component of hepatitis C therapy. (uw.edu)
  • Investigators have proposed four main potential sites of ribavirin action against hepatitis C virus: (1) augmentation of host T-cell immune clearance of HCV, (2) inhibition of the host enzyme inosine monophosphate dehydrogenase (IMPDH) that results in depleted pools of guanosine triphosphate, an essential substrate for viral RNA synthesis (3) direct inhibition of HCV replication, and (4) induction of RNA virus mutagenesis that drives HCV to an abonormally high error rate. (uw.edu)
  • Therefore, ribavirin, including COPEGUS, is contraindicated in women who are pregnant and in the male partners of women who are pregnant. (nih.gov)
  • Copegus ( Copegus )" alt=" Photo: Andrew Karpenko, University of Washington " class="linked-doc-1 document " href="//cdn.hepatitisc.uw.edu/doc/192-1/bottle-ribavirin-emcopegusem.jpg">Figure 1 ) is produced by Genentech (member of the Roche group), Rebetol by Merck Sharp & Dome, a subsidary of Merck & Co., Inc., and Ribasphere by Kadmon Pharmaceuticals (orginally by Three Rivers Pharmaceuticals which was acquired by Kadmon Pharmaceuticals). (uw.edu)
  • Assessment of potential drug-drug interactions with concomitant medications is recommended prior to starting DAA therapy and, when possible, an interacting co-medication should be stopped or switched to an alternative with less risk for potential interaction during HCV treatment. (hcvguidelines.org)
  • See Table of Drug Interactions with Direct-Acting Antivirals and Selected Concomitant Medications below or use an online resource such as University of Liverpool interaction checker . (hcvguidelines.org)
  • Clinic visits or telephone contact are recommended as clinically indicated during treatment to ensure medication adherence, and to monitor for adverse events and potential drug-drug interactions (see table of Drug Interactions with Direct-Acting Antivirals and Selected Concomitant Medications below), especially with newly prescribed medications. (hcvguidelines.org)
  • The concomitant use of TECHNIVIE and certain other drugs may result in known or potentially significant drug interactions, some of which may lead to loss of therapeutic effect of TECHNIVIE. (rxabbvie.com)
  • The anemia associated with ribavirin therapy may result in worsening of cardiac disease and lead to fatal and nonfatal myocardial infarctions. (nih.gov)
  • Because of physiologic changes in cardiorespiratory function and obligatory immunologic alterations to allow for fetal tolerance, pregnant women are vulnerable to viral infections, such as influenza. (cdc.gov)
  • The focal or multifocal nature of the pathology is responsible for the consistency of clinical presentations with distinct focal symptoms and signs viagra with dapoxetine 100/60mg otc, rather than as a more diffuse encephalopathy, or isolated dementia or behavioral syndrome, all of which are uncommon without concomitant focal findings. (gurmeeteater.ee)
  • Concomitant cation-containing antacids, laxatives, sucralfate, buffered drugs, or oral iron/calcium supplements (also can give together with a meal): give Triumeq 2hrs before or 6hrs after. (empr.com)