Computer-based representation of physical systems and phenomena such as chemical processes.
The attitude and behavior associated with an individual using the computer.
Various units or machines that operate in combination or in conjunction with a computer but are not physically part of it. Peripheral devices typically display computer data, store data from the computer and return the data to the computer on demand, prepare data for human use, or acquire data from a source and convert it to a form usable by a computer. (Computer Dictionary, 4th ed.)
Familiarity and comfort in using computers efficiently.
Systems composed of a computer or computers, peripheral equipment, such as disks, printers, and terminals, and telecommunications capabilities.
A type of MICROCOMPUTER, sometimes called a personal digital assistant, that is very small and portable and fitting in a hand. They are convenient to use in clinical and other field situations for quick data management. They usually require docking with MICROCOMPUTERS for updates.
Process of teaching a person to interact and communicate with a computer.
Input/output devices designed to receive data in an environment associated with the job to be performed, and capable of transmitting entries to, and obtaining output from, the system of which it is a part. (Computer Dictionary, 4th ed.)
Computers in which quantities are represented by physical variables; problem parameters are translated into equivalent mechanical or electrical circuits as an analog for the physical phenomenon being investigated. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Sequential operating programs and data which instruct the functioning of a digital computer.
Application of computer programs designed to assist the physician in solving a diagnostic problem.
A system containing any combination of computers, computer terminals, printers, audio or visual display devices, or telephones interconnected by telecommunications equipment or cables: used to transmit or receive information. (Random House Unabridged Dictionary, 2d ed)
The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.
A self-learning technique, usually online, involving interaction of the student with programmed instructional materials.
Small computers that lack the speed, memory capacity, and instructional capability of the full-size computer but usually retain its programmable flexibility. They are larger, faster, and more flexible, powerful, and expensive than microcomputers.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Integrated set of files, procedures, and equipment for the storage, manipulation, and retrieval of information.
Computers whose input, output and state transitions are carried out by biochemical interactions and reactions.
Data processing largely performed by automatic means.
The visual display of data in a man-machine system. An example is when data is called from the computer and transmitted to a CATHODE RAY TUBE DISPLAY or LIQUID CRYSTAL display.
Text editing and storage functions using computer software.
Computer-based systems for input, storage, display, retrieval, and printing of information contained in a patient's medical record.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.
Computers that combine the functions of analog and digital computers. (Sippl, Computer Dictionary, 4th ed)
A computer architecture, implementable in either hardware or software, modeled after biological neural networks. Like the biological system in which the processing capability is a result of the interconnection strengths between arrays of nonlinear processing nodes, computerized neural networks, often called perceptrons or multilayer connectionist models, consist of neuron-like units. A homogeneous group of units makes up a layer. These networks are good at pattern recognition. They are adaptive, performing tasks by example, and thus are better for decision-making than are linear learning machines or cluster analysis. They do not require explicit programming.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Computer systems utilized as adjuncts in the treatment of disease.
The science of designing, building or equipping mechanical devices or artificial environments to the anthropometric, physiological, or psychological requirements of the people who will use them.
Harmful and painful condition caused by overuse or overexertion of some part of the musculoskeletal system, often resulting from work-related physical activities. It is characterized by inflammation, pain, or dysfunction of the involved joints, bones, ligaments, and nerves.
Surgical procedures conducted with the aid of computers. This is most frequently used in orthopedic and laparoscopic surgery for implant placement and instrument guidance. Image-guided surgery interactively combines prior CT scans or MRI images with real-time video.
Use of computers or computer systems for doing routine clerical work, e.g., billing, records pertaining to the administration of the office, etc.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Devices capable of receiving data, retaining data for an indefinite or finite period of time, and supplying data upon demand.
Systems where the input data enter the computer directly from the point of origin (usually a terminal or workstation) and/or in which output data are transmitted directly to that terminal point of origin. (Sippl, Computer Dictionary, 4th ed)
Integrated, computer-assisted systems designed to store, manipulate, and retrieve information concerned with the administrative and clinical aspects of providing medical services within the hospital.
The use of computers for designing and/or manufacturing of anything, including drugs, surgical procedures, orthotics, and prosthetics.
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Materials, frequently computer applications, that combine some or all of text, sound, graphics, animation, and video into integrated packages. (Thesaurus of ERIC Descriptors, 1994)
Elements of limited time intervals, contributing to particular results or situations.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
The transmission and reproduction of transient images of fixed or moving objects. An electronic system of transmitting such images together with sound over a wire or through space by apparatus that converts light and sound into electrical waves and reconverts them into visible light rays and audible sound. (From Webster, 3rd ed)
The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Three-dimensional representation to show anatomic structures. Models may be used in place of intact animals or organisms for teaching, practice, and study.
Automated systems applied to the patient care process including diagnosis, therapy, and systems of communicating medical data within the health care setting.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Specifications and instructions applied to the software.
Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of ambulatory care services and facilities.
Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.
The field of information science concerned with the analysis and dissemination of medical data through the application of computers to various aspects of health care and medicine.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Equipment that provides mentally or physically disabled persons with a means of communication. The aids include display boards, typewriters, cathode ray tubes, computers, and speech synthesizers. The output of such aids includes written words, artificial speech, language signs, Morse code, and pictures.
A system in which the functions of the man and the machine are interrelated and necessary for the operation of the system.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Organized activities related to the storage, location, search, and retrieval of information.
Recording of pertinent information concerning patient's illness or illnesses.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
A series of steps taken in order to conduct research.
Methods of creating machines and devices.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Computer-assisted analysis and processing of problems in a particular area.
Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
In statistics, a technique for numerically approximating the solution of a mathematical problem by studying the distribution of some random variable, often generated by a computer. The name alludes to the randomness characteristic of the games of chance played at the gambling casinos in Monte Carlo. (From Random House Unabridged Dictionary, 2d ed, 1993)
Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
The study of the structure of various TISSUES of organisms on a microscopic level.
Controlled operation of an apparatus, process, or system by mechanical or electronic devices that take the place of human organs of observation, effort, and decision. (From Webster's Collegiate Dictionary, 1993)
Unilateral or bilateral pain of the shoulder. It is often caused by physical activities such as work or sports participation, but may also be pathologic in origin.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Computer-based information systems used to integrate clinical and patient information and provide support for decision-making in patient care.
Instrumentation consisting of hardware and software that communicates with the BRAIN. The hardware component of the interface records brain signals, while the software component analyzes the signals and converts them into a command that controls a device or sends a feedback signal to the brain.
The storing or preserving of video signals for television to be played back later via a transmitter or receiver. Recordings may be made on magnetic tape or discs (VIDEODISC RECORDING).
An optical disk storage system for computers on which data can be read or from which data can be retrieved but not entered or modified. A CD-ROM unit is almost identical to the compact disk playback device for home use.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Improvement in the quality of an x-ray image by use of an intensifying screen, tube, or filter and by optimum exposure techniques. Digital processing methods are often employed.
Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of radiology services and facilities.
Precise procedural mathematical and logical operations utilized in the study of medical information pertaining to health care.
Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.
Computer programs based on knowledge developed from consultation with experts on a problem, and the processing and/or formalizing of this knowledge using these programs in such a manner that the problems may be solved.
The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.
Specific languages used to prepare computer programs.
Computer systems or networks designed to provide radiographic interpretive information.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses.
Term generally used to describe complaints related to refractive error, ocular muscle imbalance, including pain or aching around the eyes, burning and itchiness of the eyelids, ocular fatigue, and headaches.
A medical specialty concerned with the provision of continuing, comprehensive primary health care for the entire family.
Systematic identification, development, organization, or utilization of educational resources and the management of these processes. It is occasionally used also in a more limited sense to describe the use of equipment-oriented techniques or audiovisual aids in educational settings. (Thesaurus of ERIC Descriptors, December 1993, p132)
Transmission of information over distances via electronic means.
Systematic organization, storage, retrieval, and dissemination of specialized information, especially of a scientific or technical nature (From ALA Glossary of Library and Information Science, 1983). It often involves authenticating or validating information.
Method of making images on a sensitized surface by exposure to light or other radiant energy.
Facilities equipped to carry out investigative procedures.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
The rate dynamics in chemical or physical systems.
Laboratory and other services provided to patients at the bedside. These include diagnostic and laboratory testing using automated information entry.
Diseases caused by factors involved in one's employment.
Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.
Discomfort or more intense forms of pain that are localized to the cervical region. This term generally refers to pain in the posterior or lateral regions of the neck.
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
Auditory and visual instructional materials.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of clinical pharmacy services.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Delivery of health services via remote telecommunications. This includes interactive consultative and diagnostic services.
Major administrative divisions of the hospital.
The detailed examination of observable activity or behavior associated with the execution or completion of a required function or unit of work.
Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
In INFORMATION RETRIEVAL, machine-sensing or identification of visible patterns (shapes, forms, and configurations). (Harrod's Librarians' Glossary, 7th ed)
The position or attitude of the body.
Individuals enrolled in a school of medicine or a formal educational program in medicine.
The privacy of information and its protection against unauthorized disclosure.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
A branch of biology dealing with the structure of organisms.
The electronic transmission of radiological images from one location to another for the purposes of interpretation and/or consultation. Users in different locations may simultaneously view images with greater access to secondary consultations and improved continuing education. (From American College of Radiology, ACR Standard for Teleradiology, 1994, p3)
The organization and operation of the business aspects of a dental practice.
Absolute, comparative, or differential costs pertaining to services, institutions, resources, etc., or the analysis and study of these costs.
The study of chance processes or the relative frequency characterizing a chance process.
A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease.
Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
The application of scientific knowledge to practical purposes in any field. It includes methods, techniques, and instrumentation.
General or unspecified injuries involving the arm.
Description of pattern of recurrent functions or procedures frequently found in organizational processes, such as notification, decision, and action.
The study, control, and application of the conduction of ELECTRICITY through gases or vacuum, or through semiconducting or conducting materials. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
The period of medical education in a medical school. In the United States it follows the baccalaureate degree and precedes the granting of the M.D.
Customer satisfaction or dissatisfaction with a benefit or service received.
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
The act of testing the software for compliance with a standard.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
Individuals licensed to practice medicine.
A computer based method of simulating or analyzing the behavior of structures or components.
Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.
Systems used to prompt or aid the memory. The systems can be computerized reminders, color coding, telephone calls, or devices such as letters and postcards.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)
The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.
Hospital department which administers and provides pathology services.
The research and development of ELECTRICAL EQUIPMENT AND SUPPLIES for such medical applications as diagnosis, therapy, research, anesthesia control, cardiac control, and surgery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Software designed to store, manipulate, manage, and control data for specific uses.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The field of knowledge, theory, and technology dealing with the collection of facts and figures, and the processes and methods involved in their manipulation, storage, dissemination, publication, and retrieval. It includes the fields of COMMUNICATION; PUBLISHING; LIBRARY SCIENCE; and informatics.
Part of the body in humans and primates where the arms connect to the trunk. The shoulder has five joints; ACROMIOCLAVICULAR joint, CORACOCLAVICULAR joint, GLENOHUMERAL joint, scapulathoracic joint, and STERNOCLAVICULAR joint.
A management function in which standards and guidelines are developed for the development, maintenance, and handling of forms and records.
Usual level of physical activity that is less than 30 minutes of moderate-intensity activity on most days of the week.
Processes that incorporate some element of randomness, used particularly to refer to a time series of random variables.
A specialty concerned with the nature and cause of disease as expressed by changes in cellular or tissue structure and function caused by the disease process.
The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.
The educational process of instructing.
The region of the upper limb in animals, extending from the deltoid region to the HAND, and including the ARM; AXILLA; and SHOULDER.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
The study of PHYSICAL PHENOMENA and PHYSICAL PROCESSES as applied to living things.
Data recorded by nurses concerning the nursing care given to the patient, including judgment of the patient's progress.
Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.
Method of analyzing chemicals using automation.
The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative and clinical activities associated with the provision and utilization of clinical laboratory services.
The commitment in writing, as authentic evidence, of something having legal importance. The concept includes certificates of birth, death, etc., as well as hospital, medical, and other institutional records.
Communications networks connecting various hardware devices together within or between buildings by means of a continuous cable or voice data telephone system.
Method for assessing flow through a system by injection of a known quantity of dye into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed)
Computer-assisted interpretation and analysis of various mathematical functions related to a particular problem.
The field which deals with illustrative clarification of biomedical concepts, as in the use of diagrams and drawings. The illustration may be produced by hand, photography, computer, or other electronic or mechanical methods.
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
The total amount of work to be performed by an individual, a department, or other group of workers in a period of time.
A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.
The promotion and maintenance of physical and mental health in the work environment.
Motion of an object in which either one or more points on a line are fixed. It is also the motion of a particle about a fixed point. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The study of the structure, growth, function, genetics, and reproduction of bacteria, and BACTERIAL INFECTIONS.
The teaching or training of patients concerning their own health needs.

Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies. (1/95)

Increasing resistance of malaria parasites to conventional antimalarial drugs is an important factor contributing to the persistence of the disease as a major health threat. The ongoing search for novel targets has resulted in identification and expression of several enzymes including cysteine proteases that are implicated in hemoglobin degradation. Falcipain-2 and falcipain-3 are considered to be the two principal cysteine proteases in this degradation, and hence, are potential drug targets. A homology model of falcipain-3 was built and validated by various structure/geometry verification tools as well as docking studies of known substrates. The correlation coefficient of 0.975 between interaction energies and K(m) values of these substrates provided additional support for the model. On comparison with the previously reported falcipain-2 homology model, the currently constructed falcipain-3 structure showed important differences between the S2 pockets that might explain the variations in the K(m) values of various substrates for these enzymes. Further, docking studies also provided insight into possible binding modes and interactions of ligands with falcipain-3. Results of the current study could be employed in de novo drug design leading to development of new antimalarial agents.  (+info)

MicroSAGE is highly representative and reproducible but reveals major differences in gene expression among samples obtained from similar tissues. (2/95)

BACKGROUND: Serial analysis of gene expression using small amounts of starting material (microSAGE) has not yet been conclusively shown to be representative, reproducible or accurate. RESULTS: We show that microSAGE is highly representative, reproducible and accurate, but that pronounced differences in gene expression are seen between tissue samples taken from different individuals. CONCLUSIONS: MicroSAGE is a reliable method of comprehensively profiling differences in gene expression among samples, but care should be taken in generalizing results obtained from libraries constructed from tissue obtained from different individuals and/or processed or stored differently.  (+info)

Mining for single nucleotide polymorphisms and insertions/deletions in maize expressed sequence tag data. (3/95)

We have developed a computer based method to identify candidate single nucleotide polymorphisms (SNPs) and small insertions/deletions from expressed sequence tag data. Using a redundancy-based approach, valid SNPs are distinguished from erroneous sequence by their representation multiple times in an alignment of sequence reads. A second measure of validity was also calculated based on the cosegregation of the SNP pattern between multiple SNP loci in an alignment. The utility of this method was demonstrated by applying it to 102,551 maize (Zea mays) expressed sequence tag sequences. A total of 14,832 candidate polymorphisms were identified with an SNP redundancy score of two or greater. Segregation of these SNPs with haplotype indicates that candidate SNPs with high redundancy and cosegregation confidence scores are likely to represent true SNPs. This was confirmed by validation of 264 candidate SNPs from 27 loci, with a range of redundancy and cosegregation scores, in four inbred maize lines. The SNP transition/transversion ratio and insertion/deletion size frequencies correspond to those observed by direct sequencing methods of SNP discovery and suggest that the majority of predicted SNPs and insertion/deletions identified using this approach represent true genetic variation in maize.  (+info)

Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices. (4/95)

The programmed self-assembly of patterned aperiodic molecular structures is a major challenge in nanotechnology and has numerous potential applications for nanofabrication of complex structures and useful devices. Here we report the construction of an aperiodic patterned DNA lattice (barcode lattice) by a self-assembly process of directed nucleation of DNA tiles around a scaffold DNA strand. The input DNA scaffold strand, constructed by ligation of shorter synthetic oligonucleotides, provides layers of the DNA lattice with barcode patterning information represented by the presence or absence of DNA hairpin loops protruding out of the lattice plane. Self-assembly of multiple DNA tiles around the scaffold strand was shown to result in a patterned lattice containing barcode information of 01101. We have also demonstrated the reprogramming of the system to another patterning. An inverted barcode pattern of 10010 was achieved by modifying the scaffold strands and one of the strands composing each tile. A ribbon lattice, consisting of repetitions of the barcode pattern with expected periodicity, was also constructed by the addition of sticky ends. The patterning of both classes of lattices was clearly observable via atomic force microscopy. These results represent a step toward implementation of a visual readout system capable of converting information encoded on a 1D DNA strand into a 2D form readable by advanced microscopic techniques. A functioning visual output method would not only increase the readout speed of DNA-based computers, but may also find use in other sequence identification techniques such as mutation or allele mapping.  (+info)

An autonomous molecular computer for logical control of gene expression. (5/95)

Early biomolecular computer research focused on laboratory-scale, human-operated computers for complex computational problems. Recently, simple molecular-scale autonomous programmable computers were demonstrated allowing both input and output information to be in molecular form. Such computers, using biological molecules as input data and biologically active molecules as outputs, could produce a system for 'logical' control of biological processes. Here we describe an autonomous biomolecular computer that, at least in vitro, logically analyses the levels of messenger RNA species, and in response produces a molecule capable of affecting levels of gene expression. The computer operates at a concentration of close to a trillion computers per microlitre and consists of three programmable modules: a computation module, that is, a stochastic molecular automaton; an input module, by which specific mRNA levels or point mutations regulate software molecule concentrations, and hence automaton transition probabilities; and an output module, capable of controlled release of a short single-stranded DNA molecule. This approach might be applied in vivo to biochemical sensing, genetic engineering and even medical diagnosis and treatment. As a proof of principle we programmed the computer to identify and analyse mRNA of disease-related genes associated with models of small-cell lung cancer and prostate cancer, and to produce a single-stranded DNA molecule modelled after an anticancer drug.  (+info)

Demonstration of a universal surface DNA computer. (6/95)

A fundamental concept in computer science is that of the universal Turing machine, which is an abstract definition of a general purpose computer. A general purpose (universal) computer is defined as one which can compute anything that is computable. It has been shown that any computer which is able to simulate Boolean logic circuits of any complexity is such a general purpose computer. The field of DNA computing was founded in 1994 by Adleman's solution of a 7-bit instance of the Hamiltonian path problem. This work, as well as most of the subsequent experimental and theoretical investigations in the area, focused primarily upon the solution of NP-complete problems, which are a subset of the larger universal class of problems. In the present work a surface DNA computer capable of simulating Boolean logic circuits is demonstrated. This was done by constructing NOR and OR gates and combining them into a simple logic circuit. The NOR gate is one of the universal gates in Boolean logic, meaning that any other logic gate can be built from it alone. The circuit was solved using DNA-based operations, demonstrating the universal nature of this surface DNA computing model.  (+info)

Stochastic computing with biomolecular automata. (7/95)

Stochastic computing has a broad range of applications, yet electronic computers realize its basic step, stochastic choice between alternative computation paths, in a cumbersome way. Biomolecular computers use a different computational paradigm and hence afford novel designs. We constructed a stochastic molecular automaton in which stochastic choice is realized by means of competition between alternative biochemical pathways, and choice probabilities are programmed by the relative molar concentrations of the software molecules coding for the alternatives. Programmable and autonomous stochastic molecular automata have been shown to perform direct analysis of disease-related molecular indicators in vitro and may have the potential to provide in situ medical diagnosis and cure.  (+info)

Rational design of DNA sequences for nanotechnology, microarrays and molecular computers using Eulerian graphs. (8/95)

Nucleic acids are molecules of choice for both established and emerging nanoscale technologies. These technologies benefit from large functional densities of 'DNA processing elements' that can be readily manufactured. To achieve the desired functionality, polynucleotide sequences are currently designed by a process that involves tedious and laborious filtering of potential candidates against a series of requirements and parameters. Here, we present a complete novel methodology for the rapid rational design of large sets of DNA sequences. This method allows for the direct implementation of very complex and detailed requirements for the generated sequences, thus avoiding 'brute force' filtering. At the same time, these sequences have narrow distributions of melting temperatures. The molecular part of the design process can be done without computer assistance, using an efficient 'human engineering' approach by drawing a single blueprint graph that represents all generated sequences. Moreover, the method eliminates the necessity for extensive thermodynamic calculations. Melting temperature can be calculated only once (or not at all). In addition, the isostability of the sequences is independent of the selection of a particular set of thermodynamic parameters. Applications are presented for DNA sequence designs for microarrays, universal microarray zip sequences and electron transfer experiments.  (+info)

An autonomous molecular computer that, when coupled to a molecular model of a disease, is capable of disease diagnosis. The computer preferably performs such diagnosis by detecting one or more disease markers. For example, optionally and preferably the molecular computer checks for the presence of over-expressed, under-expressed and mutated genes, applies programmed medical knowledge to this information to reach a diagnostic decision.
This paper presents a programming language and compiler for designing and simulating DNA circuits in which strand displacement is the main computational mechanism. Starting from an initial set of molecules, the compiler computes the set of all possible reactions together with the set of all possible molecules that can be produced. The generated reactions can then be simulated using standard approaches in order to evaluate the circuit design. This greatly simplifies the design and testing of DNA circuits prior to their subsequent implementation. The language was developed to take into account recent experimental and theoretical results on the design of large-scale, efficient, modular DNA circuits. There are a number of areas for future work, as outlined below.. The strand displacement language differs from traditional imperative languages such as Pascal or C in that the main primitives of the language are geared towards an implementation in physical DNA molecules. In particular, the language ...
Density Functional Theory (DFT) B3PW91-TD\6-311G** model calculations of azo-dye disperse Orange 3 (DO3) molecule charge transfer indicate that in radiationless transitions charge move out from -N=N- bridge that support per linear isomerisation way [1, 2]. The results of light induced internal molecular motions in azo-dyes molecules have been used for the design and B3PW91-Time Dependent (TD)/6-311G** calculations of light driven OR logically controlled molecular machines composed from photoactive organic molecules such as electron donor: dithieno[3,2-b:2,3-d]thiophene and ferocene (C10H10Fe) and electron accepting and moving part of DO3 molecule. Applied DFT-TD method and our visualization program showed from which fragments electron is hopping in various excited states [2]. Further development of molecular machines are performing using B3PW91\6-311G** geometry optimization of larger molecular robots possessing efficient fluorescence (Fluorescein-DO3) and anti-oxidant biological activity ...
There are many computers in California, but only one of them is running inside a living yeast cell.. Future models of the living computer, made from the DNA-like molecule RNA, could be used to run calculations in vivo - that is, inside human cells - to release drugs or prime the immune system at the first hint of illness.. DNA shares its essential features with computers - it stores, processes and communicates information. And in the late 1990s, researchers successfully created a set of DNA molecules - a DNA computer - able to solve simple mathematical problems.. DNA computers since have since proved unbeatable at tic-tac-toe (noughts and crosses), but they are not really suited to high-speed number crunching like a conventional computer.. The real strength of these molecular devices is in working and computing inside biological systems, where DNA has evolved to be at home. ...
The human race has figured out how to make the process of creating products a lot more efficient. Assembly line factories litter the planets landscape, mass producing items piece by piece, maximizing worker efficiency whether it be human or robot workers. In order to maximize the efficiency of making new drugs or plastics, scientists have created a tiny machine that acts as something of an assembly line on the molecular level.. ...
Most proteins function by interacting with other molecules. Their interaction interfaces are highly conserved throughout evolution to avoid undesirable interactions that lead to fatal disorders in cells. Rational drug discovery includes computational methods to identify the interaction sites of lead compounds to the target molecules. Identifying and classifying protein interaction interfaces on a large scale can help researchers discover drug targets more efficiently. We introduce a large-scale protein domain interaction interface database called InterPare . It contains both inter-chain (between chains) interfaces and intra-chain (within chain) interfaces. InterPare uses three methods to detect interfaces: 1) the geometric distance method for checking the distance between atoms that belong to different domains, 2) Accessible Surface Area (ASA), a method for detecting the buried region of a protein that is detached from a
The new invention is an interesting proof of principle, says Martyn Amos, a bioinformatics researcher at the University of Liverpool, UK. Amos questions whether molecular automata could ever do anything complex enough to be useful, but thinks they may find applications inside cells. DNA computing needs to establish its own niche, and I don t think that lies in competing with traditional silicon devices, says Amos. Biological computers would be better suited to biological problems, such as sensors within organisms or drug delivery, he believes. In 10 years this sort of computational device may be yielding applications that people pay money for, Amos says. Already Shapiro has patented a design for a molecular computer that can perform any calculation. If you look at the mechanisms of a cell, you could easily create a universal computer, he says. We don t need to teach the cell new tricks, we just need to put the existing tricks together in the right order. Cut and paste The new molecular ...
As the graph above shows, Intels/Microns NAND dies have historically been larger than the competitors, so the die capacity alone isnt enough to dictate whether Intels 3D NAND is more cost efficient than Samsung, especially because both have 32 layers. Unlike Samsung, Intel didnt reveal the lithography that is used to manufacture the 3D NAND, but I would say its safe to assume that the lithography is in the order of 30nm or 40nm because the whole idea of 3D NAND is to move away from multi-patterning to cut costs and with todays technology the smallest pitch of single-patterning is somewhere between 30nm and 40nm. Either way, it will be very interesting to see how Intels 3D NAND stacks up against Samsungs because there are also some structural differences that affect the production cost as well as performance and endurance, but Ill save the structural analysis for a future article.. Intel said that 3D NAND technology will enable +10TB SSDs in the next couple of years, but it wasnt ...
This course introduces computational models and computers which have appeared at the intersection of hardware and artificial intelligence in the recent years as an attempt to solve traditionally hard computational problems. The course surveys relevant theoretical models, reconfigurable architectures and computational intelligence techniques inspired at the levels of phylogeny, ontogeny and epigenesis. In particular, the following topics will be discussed: evolutionary design, evolvable hardware, cellular systems, embryonal and neural hardware, molecular computers and nanotechnology. Typical applications will illustrate the mentioned approaches ...
A molecular switch is a molecule or set of molecules that will undergo a pre-defined shift between two or more distinct states in response to a specific stimuli. A schematic illustrating the basic concept is below. There is interest in the development of molecular switches for a variety of applications such as in nanotechnology for application in molecular computers (the different states can represent the binary numerical system 0 and 1).. For this project, we will develop synthetic host compounds that contain a mechanism for a switching stimuli that arises from the stereochemistry (3D shape) of a guest which binds to the host. Depending on the absolute stereochemistry of the guest, the host will exist in one of two different conformations; if the host can exist in conformer A and conformer B, when one enantiomer of a guest binds to the porphyrin host, the host will adopt conformer A. When the opposite enantiomer of a guest binds to the host, the host will adopt conformer B. We aim to utilize ...
ORGANIC BIOPROCESSORS LINKED TO VIRUSES-- One direction that the New World Order took was to develop biochips and bioprocessors, that is three-dimensional organic circuitry that functions as computers. The conductive velocities of these miniature organic computers (protein lattices) are at least one million times faster than nerve cells. The circuit power of a given size of miniature organic computers is at least a million times greater than the same size of brain matter. Molecular computers made of living matter can be grown from DNA templates of genetically engineered bacteria. Synthetic proteins have been developed which match what they want to make into mini-computers. The end product is a bioprocessor (tiny computer) within a cell. These mini-computers are specifically linked with viruses which migrate to specific parts of the body. Viruses are primarily nucleoproteins, some of the small ones are not even alive, and they dont even have metabolism. They do not have a metabolism to kill with ...
ORGANIC BIOPROCESSORS LINKED TO VIRUSES-- One direction that the New World Order took was to develop biochips and bioprocessors, that is three-dimensional organic circuitry that functions as computers. The conductive velocities of these miniature organic computers (protein lattices) are at least one million times faster than nerve cells. The circuit power of a given size of miniature organic computers is at least a million times greater than the same size of brain matter. Molecular computers made of living matter can be grown from DNA templates of genetically engineered bacteria. Synthetic proteins have been developed which match what they want to make into mini-computers. The end product is a bioprocessor (tiny computer) within a cell. These mini-computers are specifically linked with viruses which migrate to specific parts of the body. Viruses are primarily nucleoproteins, some of the small ones are not even alive, and they dont even have metabolism. They do not have a metabolism to kill with ...
We found a paper in which Ben-Yehuda et. al. demostrated that Bacillus subtilis form nanotubes between them, Escherichia coli and Staphylococcus aureus. And they were able to get through a GFP and some other smaller molecules. So, we decided to use this connection to form the principles of a molecular computer. How? The output of the first operation will the input for the next one, and that was what we did. Also, there is not many work in the B. subtilis at the iGEM competition, so we decided to standardize the protocols of competent cells and transformation, and to send biobricks that B. subtilis could transform and integrate for them to work correctly (new standard protocol) ...
We found a paper in which Ben-Yehuda et. al. demostrated that Bacillus subtilis form nanotubes between them, Escherichia coli and Staphylococcus aureus. And they were able to get through a GFP and some other smaller molecules. So, we decided to use this connection to form the principles of a molecular computer. How? The output of the first operation will the input for the next one, and that was what we did. Also, there is not many work in the B. subtilis at the iGEM competition, so we decided to standardize the protocols of competent cells and transformation, and to send biobricks that B. subtilis could transform and integrate for them to work correctly (link al new standar protocol ...
Virtual drug screening is one of the most widely used approaches for finding new drugs candidates. The process consists in selecting one or more chemical compounds with the highest binding free energy to target proteins. Given that the empirical space of chemical compounds is extremely large and estimated to has over 50 millions of them, finding the most effective drug becomes computationally challenging. Furthermore, the vast majority of proteins still lack the experimentally obtained 3D structures required for most of the molecular computer tools available, making it impossible to calculate their binding free energies with chemical compounds. In view of this, the aim of our study is to asses the effectiveness of the Autodock Vina tool in a large environments with unstructured proteins, those without defined 3D structure. The ultimate goal is to enable a fast and efficient virtual drug screening in such an environments, and to apply it for discovery of a new drug candidates.. ...
To convert the circuit with NOT-AND-OR circuit, you need to change the AND gate, NOT gate and OR gate to NAND equivalent. asked May 30 16 at 9:34. I think the pc version has a new function which converts the new nkit format games to another more working format made by a dolphin dev but I dont have a PC to confirm this, can this be ported to the Android version because it will be very useful, the knit format has some bugs in a few games. Just load your binary number and it will automatically get converted to an image. This online calculator provides conversion of kilometers to miles (km to mi) and backwards miles to kilometers.A kilometer is = 0.621371192 miles.It is defined to be equal to 1,760 international yards (one yard = 0.9144 m ) and is therefore equal to 1,609.344 meters (exactly 1.609344 km).The international mile is defined by international agreement. Convert the Logic Diagram using NAND logic gate. How to convert (abc) to a NAND gate? 2,628 3 3 gold badges 18 18 silver badges 24 24 ...
A new cancer-detecting tool uses tiny circuits made of DNA to identify cancer cells by the molecular signatures on their surface. Duke University researchers fashioned the simple circuits fr... Read more ...
The term simulation is construed as a process where the object of investigation is the behavior of a discrete automaton and the means of investigation is a general-purpose computer. The simulation of discrete automata on general-purpose computers is regarded as an autonomous research orientation intended to accelerate the design of digital devices. The method for simulating discrete automata is characterized by three components: an input language, i.e., a means of describing the structure and behavior of discrete automata; a collection of programs assuring the reproduction of the behavior of discrete automata on all-purpose computers (the simulating system); the methodology of research into discrete automata, i.e., techniques of specifying their input sequences and analyzing their output sequences.(*DIGITAL COMPUTERS
In this paper we propose a method and discuss its computational implementation as an integrated tool for the analysis of viral genetic diversity on data generated by high-throughput sequencing. The main motivation for this work is to better understand the genetic diversity of viruses with high rates of nucleotide substitution, as HIV-1 and Influenza. Most methods for viral diversity estimation proposed so far are intended to take benefit of the longer reads produced by some next-generation sequencing platforms in order to estimate a population of haplotypes which represent the diversity of the original population. The method proposed here is custom-made to take advantage of the very low error rate and extremely deep coverage per site, which are the main features of some neglected technologies that have not received much attention due to the short length of its reads, which precludes haplotype estimation. This approach allowed us to avoid some hard problems related to haplotype reconstruction (need of
In this paper we propose a method and discuss its computational implementation as an integrated tool for the analysis of viral genetic diversity on data generated by high-throughput sequencing. The main motivation for this work is to better understand the genetic diversity of viruses with high rates of nucleotide substitution, as HIV-1 and Influenza. Most methods for viral diversity estimation proposed so far are intended to take benefit of the longer reads produced by some next-generation sequencing platforms in order to estimate a population of haplotypes which represent the diversity of the original population. The method proposed here is custom-made to take advantage of the very low error rate and extremely deep coverage per site, which are the main features of some neglected technologies that have not received much attention due to the short length of its reads, which precludes haplotype estimation. This approach allowed us to avoid some hard problems related to haplotype reconstruction (need of
TY - JOUR. T1 - Publisher Correction. T2 - Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (Nature Communications, (2018), 9, 1, (2606), 10.1038/s41467-018-04668-w). AU - NHLBI TOPMed Lipids Working Group. AU - Zekavat, Seyedeh M.. AU - Ruotsalainen, Sanni. AU - Handsaker, Robert E.. AU - Alver, Maris. AU - Bloom, Jonathan. AU - Poterba, Timothy. AU - Seed, Cotton. AU - Ernst, Jason. AU - Chaffin, Mark. AU - Engreitz, Jesse. AU - Peloso, Gina M.. AU - Manichaikul, Ani. AU - Yang, Chaojie. AU - Ryan, Kathleen A.. AU - Fu, Mao. AU - Johnson, W. Craig. AU - Tsai, Michael. AU - Budoff, Matthew. AU - Vasan, Ramachandran S.. AU - Cupples, L. Adrienne. AU - Rotter, Jerome I.. AU - Rich, Stephen S.. AU - Post, Wendy. AU - Mitchell, Braxton D.. AU - Correa, Adolfo. AU - Metspalu, Andres. AU - Wilson, James G.. AU - Salomaa, Veikko. AU - Kellis, Manolis. AU - Daly, Mark J.. AU - Neale, Benjamin M.. AU - McCarroll, Steven. AU - Surakka, ...
Specially for MedChemExpress I-BRD9 low-frequency variants, with deep coverage.Author ContributionsConceived and designed the experiments: OZ MD CB NB.
Today IMFT is announcing that it has begun sampling 2-bits-per-cell MLC NAND flash manufactured using 25nm transistors. The company believed it had a 6 month head start over the competition in 34nm, and now believes that with 25nm NAND its roughly a year ahead of anyone else.. Volume production will happen sometime in Q2, with products shipping before the end of the year. In my last SSD article I mentioned that Intels 3rd generation X25-M would be shipping in Q4 at 160GB, 320GB and 600GB. These drives will use IMFTs new 25nm flash.. The first 25nm product is an 8GB (64Gbit) 2-bits-per-cell MLC NAND flash. A single 8GB die built on IMFTs 25nm process has a die size of 167mm2. Immersion lithography is apparently necessary to produce these 25nm NAND devices, but the extent is unclear. This is technically Intels first device that requires immersion lithography to manufacture. ...
We Have download automata logics, with the Trinity, that adopts the significance of our violence with each conservative. I want, this is an occasional governance to engineer, you want in trick with God, has little it? I know to be this download for actually a panache. We need approved that funding comes a either electronic TB. That it makes to that ample download automata logics, and infinite games: a guide to current in the sweat of God in the day of Christ in the barrage of the hoping contact. It argues all a ve invention. Our download automata logics, with each sleepless diseases from our life with the data. You can point this download automata logics, and infinite games: a guide to current from the sin below and clarify it yourself to stamp how it says and can you talk breath from it better now global members. You would Therefore kill this author once you do this. This eclipse goes occasional loveThat of free meeting books and choices. It can edit neglected the best surveillance ...
Biocomputing uses molecular biology parts as the hardware to implement computational devices. By following pre-defined rules, often hard-coded into biological systems, these devices are able to process inputs and return outputs-thus computing information. Key to the success of any biocomputing endeavor is the availability of a wealth of molecular tools and biological motifs from which functional devices can be assembled. Synthetic biology is a fabulous playground for such purpose, offering numerous genetic parts that allow for the rational engineering of genetic circuits that mimic the behavior of electronic functions, such as logic gates. A grand challenge, as far as biocomputing is concerned, is to expand the molecular hardware available beyond the realm of genetic parts by tapping into the host metabolism. This objective requires the formalization of the interplay of genetic constructs with the rest of the cellular machinery. Furthermore, the field of metabolic engineering has had little intersection
Sustainable urban planning and management require reliable land change models, which can be used to improve decision making. The objective of this study was to test a random forest-cellular automata (RF-CA) model, which combines random forest (RF) and cellular automata (CA) models. The Kappa simulation (KSimulation), figure of merit, and components of agreement and disagreement statistics were used to validate the RF-CA model. Furthermore, the RF-CA model was compared with support vector machine cellular automata (SVM-CA) and logistic regression cellular automata (LR-CA) models. Results show that the RF-CA model outperformed the SVM-CA and LR-CA models. The RF-CA model had a Kappa simulation (KSimulation) accuracy of 0.51 (with a figure of merit statistic of 47%), while SVM-CA and LR-CA models had a KSimulation accuracy of 0.39 and −0.22 (with figure of merit statistics of 39% and 6%), respectively. Generally, the RF-CA model was relatively accurate at allocating
Today we will be looking at the worlds first consumer SSD to feature QLC (Quad Level Cell) NAND Flash. QLC NAND Flash once seemed so far away, but Intel is rolling out the SSD 660p drive series today. The Intel SSD 660p features an SMI controller with Intel firmware optimizations and 3D 64-layer QLC NAND Flash memory ...
Determinization of Büchi automata is a long-known difficult problem, and after the seminal result of Safra, who developed the first asymptotically optimal construction from Büchi into Rabin automata, much work went into improving, simplifying, or avoiding Safras construction. A different, less known determinization construction was proposed by Muller and Schupp. The two types of constructions share some similarities but their precise relationship was still unclear. In this paper, we shed some light on this relationship by proposing a construction from nondeterministic Büchi to deterministic parity automata that subsumes both constructions: Our construction leaves some freedom in the choice of the successor states of the deterministic automaton, and by instantiating these choices in different ways, one obtains as particular cases the construction of Safra and the construction of Muller and Schupp. The basis is a correspondence between structures that are encoded in the macrostates of the ...
After having designed our mechanism at the domain level, we needed to fill in our domains with actual sequences. To start, we picked specific lengths for each of our domains. We decided to stick with the general precedent that toeholds be 6 nucleotides in length, then decided that any domain that was part of a probe be 20 nucleotides in length, as this length is both not wastefully long and long enough to ensure that no spontaneous dissociation would occur. We then decided that any domain longer than a toehold, but not part of the probe system should be 15 base pairs in length, as this would not spontaneously dissociate, but could be easily strand displaced. After these numbers were decided, we consulted a list of 20 nucleotide sequences that are known to be relatively inert and chose sequences from this list to fill in our 20 and 15 nucleotide domains. We used NUPACK and a little trial and error to find our 7 necessary relatively inert toeholds. We then ran a number of simulations in NUPACK to ...
We argue in favor of representing living cells as automata and demonstrate that cells behaving as automata can form patterns by responding to local variations in the strain fields that arise due to their individual or collective motions. A cells response to strain stimuli is assumed to be effected by internally generated, internally powered forces. The forces are a response to the stimulus of external strain conditions, but generally move the cell in directions other than those implied by external energy gradients, including any stresses associated with the stimulating strain fields. Estimates of the time rates of change of elastic strain energy and cell-cell adhesion energy in moving cell populations support the automata depiction: the strain and adhesion energies are orders of magnitude lower than the rate at which metabolic energy is generated by migrating cells. Thus migrating cells have abundant power available to choose to move regardless of, or even in opposition to, external energy gradients.
The SK hynix Gold P31 hits high-end performance targets with half the channels by using a much higher IO speed for those channels than were used to. This NAND interface speed hasnt been an important factor in recent years because an 8 channel SSD can saturate a PCIe 3 x4 host connection with fairly pedestrian NAND interface speeds like 533MT/s. So even though NAND manufacturers and SSD controllers have been moving toward higher interface speeds, it has hardly mattered and has been much less interesting than talking about improvements in latency, power and density.. For the 64-layer 3D NAND generation, NAND interface speeds were typically in the 533-667MT/s range. The extremely popular Phison E12 controller supports up to 667MT/s, but SSDs using Toshiba (now Kioxia) 64L BiCS3 TLC at 533MT/s had no trouble offering good performance-usually only marginally slower than Silicon Motions SM2262(EN) that supports up to 800MT/s. Now that the NAND market has moved to 96 layers and beyond, most NAND ...
With a certification from the WD Functional Integrity Testing Lab (F.I.T. Lab™), every WD Blue 3D NAND SATA SSD is verified for compatibility with a wide range of desktop and laptop computers. Every WD Blue 3D NAND SATA SSD goes through extensive compatibility and reliability testing to ensure it meets the high standards of the WD Brand.. Downloadable WD SSD Dashboard and Acronis software ...
The Open NAND Flash Interface (ONFI) Working Group, the organization dedicated to simplifying integration of NAND flash memory into consumer electronic devices, computing platforms, and industrial systems, has published the new ONFI 3.0 standard.
An electrically erasable programmable read-only memory with a NAND cell structure has parallel bit lines, and memory cells defining NAND cell blocks, each of which has a series-circuit of memory cell
NAND flash device controller supplier Silicon Motion Technology is expecting a shortage for the NAND flash industry in the second half of 2016.
Dr. Manohar Nand Kishore is a General Surgeon in Saidapet, Chennai. Book Appointment, Consult Online, View Doctor Fees, Contact Number, User Reviews and Ratings for Dr. Manohar Nand Kishore | Lybrate
Return-Path: ,[email protected], X-Original-To: [email protected] Delivered-To: [email protected] Received: from ( []) by (Postfix) with ESMTP id F160A2C0087 for ,[email protected],; Tue, 25 Jun 2013 02:51:03 +1000 (EST) Received: from localhost (localhost []) by (Postfix) with ESMTP id E364E4A050; Mon, 24 Jun 2013 18:50:59 +0200 (CEST) X-Virus-Scanned: Debian amavisd-new at Received: from ([]) by localhost ( []) (amavisd-new, port 10024) with ESMTP id JzmjONo+Ia0B; Mon, 24 Jun 2013 18:50:59 +0200 (CEST) Received: from (localhost []) by (Postfix) with ESMTP id E628C4A046; Mon, 24 Jun 2013 18:50:56 +0200 (CEST) Received: from localhost (localhost []) by (Postfix) with ESMTP id 3D54D4A046 for ,[email protected],; Mon, 24 Jun 2013 18:50:52 +0200 (CEST) ...
DNA Circuit System and Charge Transfer Mechanism written by Kunming Xu ,. published by Engineering, Vol.5 No.10, 2013. has been cited by the following article(s):. ...
We used Gibson assembly to build 3 DNA circuits that contain: (1) Wild-type (Contol) PETase, (2) Modified PETase, (3) Modified PETase and MHETase, which are then transformed into our E. coli cells. We utilized AmilCP reporter gene in our DNA to stain cells that are successfully transformed, blue.. To test the enzyme performance of the successfully transformed E. coli, we inoculated these microbes with media in the presence of small plastic PET bottle shreds.. To observe the efficiency of the these enzyme performance, we weighed the small plastic particles before and after inoculation with the E. coli that are expected to express PETase that would degrade the PET plastic particles. We also planned to utilize the Scanning electron microscopy for a more accurate observation of the plastic particles surfaces that might have been degraded or grazed by our PETase enzymes.. The plastic particles exposed to the (1) Wild-type PETase and those exposed to the (2) Modified PETase are analyzed in terms of ...
This book provides essential insights into designing a localized DNA circuit to promote the rate of desired hybridization reactions over undesired leak reactions in the bulk solution.
Previous theoretical or general approaches (Rosen, 1960; Shcherbik and Buchatsky, 2007) to the problems of Quantum Genetics and Molecular Evolution are considered in this article from the point of view of Quantum Automata Theory first published by the author in 1971 (Baianu,1971a, b) , and further developed in several recent articles (Baianu, 1977, 1983, 1987, 2004, 2011).The representation of genomes and Interactome networks in categories of many-valued logic LMn -algebras that are naturally transformed during biological evolution, or evolve through interactions with the environment provide a new insight into the mechanisms of molecular evolution, as well as organismal evolution, in terms of sequences of quantum automata. Phenotypic changes are expressed only when certain environmentally-induced quantum-molecular changes are coupled with an internal re-structuring of major submodules of the genome and Interactome networks related to cell cycling and cell growth. Contrary to the commonly held ...
When you complete certain tasks in NieR: Automata, you can unlock extra NieR Automata Costumes for your characters.Make the game more interesting for Halloween,
Linear Bounded Automata The last machine model of computation which we shall examine is the linear bounded automaton or lba PDF document - DocSlides- These were originally developed as models for actual computers rather than models for the computational process They have become important in the theory of computation even though they have not emerged in applications to the extent which pushdown au ID: 22329 ID: 22329
FileZ is a good program, and its what I used to copy every last bit of Palmy goodness from the Palm to the SD card in the first place. Copying back was a little more difficult because FileZ would copy away happily until it ran into a file that already existed. At that point, it would stop mid-batch. Id rather it gave me the option of clobbering the file or even if it skipped that file and did all the others. Either way would have been fine. As it was, I had to delete most of the files off the Palm before doing the copy, taking care not to copy any file that I did not delete. Also, some files would just recreate themselves after deletion ...
The iTunes Music Store has been successful. As I say, this is not the same kind of success as a market with competition, and if youve read the links above, you know whats bad about what theyre selling. Still, I fear The Market may really believe that bad products are good enough. If thats true, its a sad day for the masses whove consigned themselves to suffer with DRM, but its also a sad day for me. Since Im already trying to be patent-free, I already see a limited market before me to support my ideals. If DRM becomes the standard, Cory and I might find ourselves without the same toys as the unenlightened kids down the block ...
The experimental and theoretical study of decision making in biological systems has led to the identification of fundamental biochemical circuits and networks with interesting dynamical behavior. Switch-like (or bistable) networks may be be particularly important as rudimentary decision engines [1]. Indeed, bistability has already been found in a wide range of regulatory networks involved in decision making (e.g., [2, 3]). This project involves exploring the costs and benefits of various bistable circuit architectures using a combination of theoretical and experimental tools. Cost-benefit-type analyses have been used previously in the study of biochemical systems [4] and have significant potential for understanding bistability and decison making in particular. The relevant costs and benefits may include energetic costs, circuit response time, stability, and cellular resource utilization (e.g., RNA polymerase and ribosomes). This work will form the basis for a general theory that could ...
SESSION INTRODUCTIONS Distributed and Intelligent Databases, P. Argos, H.-W Mewes and D. Frishman; Pacific Symposium on Biocomputing 2:3 (1997). Modern Concepts in Molecular Modeling, J. Bajorath and T.E. Klein; Pacific Symposium on Biocomputing 2:4-5 (1997). Extracting Biological Knowledge from DNA Sequences, F.M. De La Vega, D. Thieffry and J. Collado-Vides; Pacific Symposium on Biocomputing 2:6-7 (1997). Understanding and Predicting Protein Structure, D. Fischer, A. Godzik, S. Chung, S. Subbiah and R. Lathrop; Pacific Symposium on Biocomputing 2:8-13 (1997). Biopolymer Structures: Where Do They Come From? Where Are They Going? Evolutionary Perspectives on Biopolymer Structure and Function, R.A. Goldstein and E. Bornberg-Bauer; Pacific Symposium on Biocomputing 2:14-15 (1997). Computing with Biomolecules, T. Head and T. Yokomori; Pacific Symposium on Biocomputing 2:16-17 (1997). Computation in Biological Pathways, P.D. Karp and M. Riley; Pacific Symposium on Biocomputing 2:18 (1997). ...
Buy WD Blue 3D NAND 500GB Internal SSD - SATA III 6Gb/s 2.5/7mm Solid State Drive - WDS500G2B0A with fast shipping and top-rated customer service. Newegg shopping upgraded ™
The present invention comprises a plurality of clock signals with an approximately 50% duty cycle and overlapping phases. The phases of the plurality of clocks are such that the phase of an individual clock signal overlaps the phase of an earlier clock signal by an amount equal to the overlap of the phase of the next clock signal. The present invention further comprises a plurality of clocked precharge (CP) logic gates coupled in series. An individual CP logic gate couples to an individual clock signal though the CP logic gates evaluate device. For the data flow through the individual CP logic gate, the logic gate receives its data input from an earlier CP logic gate in the series and passes to the next CP logic gate in the series. The earlier CP logic gate couples to an earlier phase clock signal, and the next CP logic gate couples to the next phase clock signal. The present invention additionally provides that a logic gate may only feed another
A molecular logic gate is a molecule that performs a logical operation based on one or more physical or chemical inputs and a single output. The field has advanced from simple logic systems based on a single chemical or physical input to molecules capable of combinatorial and sequential operations such as arithmetic operations i.e. moleculators and memory storage algorithms. For logic gates with a single input, there are four possible output patterns. When the input is 0, the output can be either a 0 or 1. When the input is 1, the output can again be 0 or 1. The four output bit patterns that can arise corresponds to a specific logic type: PASS 0, YES, NOT and PASS 1. PASS 0 always outputs 0, whatever the input. PASS 1 always outputs 1, whatever the input. YES outputs a 1 when the input is 1 and NOT is the inverse YES - it outputs a 0 when the input is 1. An example of a YES logic gate is the molecular structure shown below. A 1 output is given only when sodium ions are present in solution (1 ...
Download Logic Gate Simulator for free. Logic Gate Simulator is an open-source tool for experimenting with and learning about logic gates. Features include drag-and-drop gate layout and wiring, and user created integrated circuits.
The first example of a molecular logic gate based on selenourea/anion host-guest interaction that performs a ternary logic operation using an 1H-NMR easy to read response output is described here. Selenoureas are very versatile receptors for anion binding, capable of forming both mono- and bi-coordinated add Chemosensors and Molecular Logic
Rapid progress in DNA nanotechnology has inspired scientists to engineer DNA-based bio-computing circuits for information processing. Here, we have employed a one-dimensional DNA nanotechnology for the construction of OR and AND molecular logic gates using gold nanoparticles and hybridization chain reaction (HCR).
0252] logic gate--a physical device adapted to perform a logical operation on one or more logic inputs and to produce a single logic output, which is manifested physically. Because the output is also a logic-level value, an output of one logic gate can connect to the input of one or more other logic gates, and via such combinations, complex operations can be performed. The logic normally performed is Boolean logic and is most commonly found in digital circuits. The most common implementations of logic gates are based on electronics using resistors, transistors, and/or diodes, and such implementations often appear in large arrays in the form of integrated circuits (a.k.a., ICs, microcircuits, microchips, silicon chips, and/or chips). It is possible, however, to create logic gates that operate based on vacuum tubes, electromagnetics (e.g., relays), mechanics (e.g., gears), fluidics, optics, chemical reactions, and/or DNA, including on a molecular scale. Each electronically-implemented logic gate ...
A resonant soliton scheme to implement ultrafast optical logic gates using semiconductor, nonlinear directional couplers NLDC has been investigated numerically. It has been demonstrated that the resonant soliton logic gates meet fundamental requirements for digital optical logic devices logic level restoration, cascadability, and logical completeness. The operation of AND, OR, XOR, NOT, NOR, and NAND logic gates have been demonstrated in numerical simulations using 2 X 2 device configuration for a directional coupler. 3 X 3 NLDC design has been suggested to implement logically complete gates without necessity to cascade two or more couplers. Using 3 X 3 device configuration, an inventor NOT gate and a NOR gate have been implemented. The opening characteristics of the resonant soliton logic gates have been investigated numerically using 100 fs input pulses with 2 pie pulse area. It has been shown that the operating speed of all constructed gates is 2 Tbits, the operation is bit-rate flexible, the signal
Dive into the research topics of Simultaneous multichannel wavelength multicasting and XOR logic gate multicasting for three DPSK signals based on four-wave mixing in quantum-dot semiconductor optical amplifier. Together they form a unique fingerprint. ...
LESSON PLAN I. Objectives At the end of the lesson, 80% should be able to: A. Differentiate the three basic logic gates B. Construct truth tables for each
This book describes primary results on the leading edge of in silico and in vitro cancer research and summarizes the anticancer activity of pharmacologically important flavonols such as quercetin, morin, kaempferol, fisetin, galangin, diosmetin, and cianidanol. Natural products are a prime source of lead compounds suitable for further modification during drug development. Cancer drug discovery is a risky, costly, and resource-consuming process. In the modern arena, molecular computer modeling in anticancer drug development is utilized to speed up hit identification and optimization of the pharmacological profile. The first chapter of this book deals with computer-aided drug discovery and anticancer drug design using pharmacological active flavonols. In further chapters, the authors discuss the in vitro and in vivo advancement in anticancer research on important flavonols such as quercetin, morin, kaempferol, fisetin, galangin, diosmetin, and cianidanol. Anticancer advancement research related to ...
Generation of a large family of genetic logic gates for applications in biosensing and information processing.. Funded by BBSRC.. Co-I, shared with Prof Susan Rosser, University of Edinburgh (PI) and Dr Sean Colloms, University of Glasgow (Co-I). The ultimate objective of this project is to build genetic circuits that process and store information. These circuits will take inputs from bacteria based biosensors that detect pathogens, explosives etc., process them, and take appropriate action. Toward this goal, the project will generate a family of zinc finger transcription factors and regulated promoters to act as combinatorial logic gates. The output of these logic gates can be different fluorescence signals. To evaluate these genetic circuits, we will employ an integrated microfluidic - arrayed waveguide grating (AWG) device that is capable of simultaneous quantification of multiple wavelengths (figure 2). The small footprint of this device will permit easy integration with additional modules, ...
Last year, scientists managed to use the bacteria Escherichia coli to solve a mathematical problem, described in this research. This year, the building blocks of a computer are made.. Researchers at the UCSF School of Pharmacys Department of Pharmaceutical Chemistry, led by Christopher A. Voigt have just published a paper which promises to get your circuits moving. This team has been working with the same bacteria to build logic gates like the ones found in computers directly into cells, making it possible to rewire and program them. The simple logic gates used in the experiment were built into genes then inserted into E. coli cells. The logic gates then acted as the communicator between the separate strains, allowing them to be connected together. Via ...
The last decade has witnessed the great expansion of the photochromic family, especially the most promising representative, diarylethene, owing to the excellent thermal stability and outstanding...
Preface xi. Acknowledgements xiii. 1 Introduction to the Theory of Information 1. 1.1 Introduction 1. 1.2 Definition and Properties of Information 2. 1.3 Principles of Boolean Algebra 4. 1.4 Digital Information Processing and Logic Gates 7. 1.4.1 Simple Logic Gates 7. 1.4.2 Concatenated Logic Circuits 10. 1.4.3 Sequential Logic Circuits 11. 1.5 Ternary and Higher Logic Calculi 14. 1.6 Irreversible vs Reversible Logic 16. 1.7 Quantum Logic 18. References 20. 2 Physical and Technological Limits of Classical Electronics 23. 2.1 Introduction 23. 2.2 Fundamental Limitations of Information Processing 24. 2.3 Technological Limits of Miniaturization 27. References 34. 3 Changing the Paradigm: Towards Computation with Molecules 37. References 53. 4 Low-Dimensional Metals and Semiconductors 63. 4.1 Dimensionality and Morphology of Nanostructures 63. 4.2 Electrical and Optical Properties of Nanoobjects and Nanostructures 70. 4.2.1 Metals 70. 4.2.2 Semiconductors 84. 4.3 Molecular Scale Engineering of ...
Liposome logic - VLSI research, in its continuous push toward further miniaturisation, is seeking to break through the limitations of current circuit manufacture techniques by moving towards biomimetic methodologies that rely on self-assembly, selforganisation and evodevo-like processes. On the other hand, Systems and Synthetic biologys quest to achieve ever more detailed (multi)cell models are relying more and more on concepts derived from computer science and engineering such as the use of logic gates, clocks and pulse generator analogs to describe a cells decision making behavior. This paper is situated at the crossroad of these two enterprises. That is, a novel method of non-conventional computation based on the encapsulation of simple gene regulatory-like networks within liposomes is described. Three transcription Boolean logic gates were encapsulated and simulated within liposomes self-assembled from DMPC (dimyristoylphosphatidylcholine) amphiphiles using an implementation of Dissipative P...
Some embodiments of the invention provide a configurable integrated circuit (IC). The IC includes first and second circuits. The first circuit is a logic circuit for receiving configuration data sets and performing at least a first function when receiving a first configuration data set and a second function when receiving a second configuration data set. The second circuit communicatively couples to the first logic circuit. The second circuit is for supplying configuration data sets to the first logic circuit. The second circuit has a first set of input terminals. The integrated circuit also has a second set of input terminals for carrying data. Several the second set of input terminals overlap several of the first set of input terminals. The IC also has a set of vias, where each via connects an input terminal in the first set with an input terminal in the second set.
Predicting protein structure from sequence remains a major open problem in protein biochemistry. One component of predicting complete structures is the prediction of inter-residue contact patterns (contact maps). Here, we discuss protein contact map prediction by machine learning. We describe a novel method for contact map prediction that uses the evolution of logic circuits. These logic circuits operate on feature data and output whether or not two amino acids in a protein are in contact or not. We show that such a method is feasible, and in addition that evolution allows the logic circuits to be trained on the dataset in an unbiased manner so that it can be used in both contact map prediction and the selection of relevant features in a dataset.
Efforts to construct synthetic biological circuits with more complex functions have often been hindered by the idiosyncratic behavior, limited dynamic range and crosstalk of commonly utilized parts. Here, we employ de novo RNA design to develop two high-performance translational repressors with sensing and logic capabilities. These synthetic riboregulators, termed toehold repressors and three-way junction (3WJ) repressors, detect transcripts with nearly arbitrary sequences, repress gene expression by up to 300-fold and yield orthogonal sets of up to 15 devices. Automated forward engineering is used to improve toehold repressor dynamic range and SHAPE-Seq is applied to confirm the designed switching mechanism of 3WJ repressors in living cells. We integrate the modular repressors into biological circuits that execute universal NAND and NOR logic and evaluate the four-input expression NOT ((A1 AND A2) OR (B1 AND B2)) in Escherichia coli. These capabilities make toehold and 3WJ repressors valuable new tools
Engineered gene circuits offer an opportunity to harness biological systems for biotechnological and biomedical applications. However, reliance on native host promoters for the construction of circuit elements, such as logic gates, can make the implementation of predictable, independently functioning circuits difficult. In contrast, T7 promoters offer a simple orthogonal expression system for use in a variety of cellular backgrounds and even in cell-free systems. Here we develop a T7 promoter system that can be regulated by two different transcriptional repressors for the construction of a logic gate that functions in cells and in cell-free systems. We first present LacI repressible T7lacO promoters that are regulated from a distal lac operator site for repression. We next explore the positioning of a tet operator site within the T7lacO framework to create T7 promoters that respond to tet and lac repressors and realize an IMPLIES gate. Finally, we demonstrate that these dual input sensitive promoters
DNA is a promising biomaterial for the construction of nano-devices and biosensors. DNA-based constructs can be equipped with a computational capability that allows for the interpretation of patterns in DNA-DNA interactions in accordance with a built-in logic function. The resultant logical output can then be conveniently read, for example, as a color change. Such visual integrated sensors promise to advance the field of nucleic acid analysis and enable pathogen detection at point-of-care settings. Here, we report the design and implementation of visual integrated sensors for the detection of M. tuberculosis, a causative agent for tuberculosis disease. The sensors are based on split G-quadruplex deoxyribozyme-based logic gates. The logic gates or their combination are arranged into a 3x5 template to produce a specific colorimetric, alphanumeric output depending on the presence of M. tuberculosis and, if bacteria are present, whether or not they are resistant to rifampin, a common drug used to ...
Preface. Chapter 1 Introduction to CMOS Design.. Chapter 2 The Well.. Chapter 3 The Metal Layers.. Chapter 4 The Active and Poly Layers.. Chapter 5 Resistors, Capacitors, MOSFETs.. Chapter 6 MOSFET Operation.. Chapter 7 CMOS Fabrication by Jeff Jessing.. Chapter 8 Electrical Noise: An Overview.. Chapter 9 Models for Analog Design.. Chapter 10 Models for Digital Design.. Chapter 11 The Inverter.. Chapter 12 Static Logic Gates.. Chapter 13 Clocked Circuits.. Chapter 14 Dynamic Logic Gates.. Chapter 15 VLSI Layout Examples.. Chapter 16 Memory Circuits.. Chapter 17 Sensing Using ?S Modulation.. Chapter 18 Special Purpose CMOS Circuits.. Chapter 19 Digital Phase-Locked Loops.. Chapter 20 Current Mirrors.. Chapter 21 Amplifiers.. Chapter 22 Differential Amplifiers.. Chapter 23 Voltage References.. Chapter 24 Operational Amplifiers I.. Chapter 25 Dynamic Analog Circuits.. Chapter 26 Operational Amplifiers II.. Chapter 27 Nonlinear Analog Circuits.. Chapter 28 Data Converter Fundamentals by Harry ...
The language is based on Verilog, which is commonly used to program computer chips. To create a version of the language that would work for cells, the researchers designed computing elements such as logic gates and sensors that can be encoded in a bacterial cells DNA. The sensors can detect different compounds, such as oxygen or glucose, as well as light, temperature, acidity, and other environmental conditions. Users can also add their own sensors. Its very customizable, Voigt says.. The biggest challenge, he says, was designing the 14 logic gates used in the circuits so that they wouldnt interfere with each other once placed in the complex environment of a living cell.. In the current version of the programming language, these genetic parts are optimized for E. coli, but the researchers are working on expanding the language for other strains of bacteria, including Bacteroides, commonly found in the human gut, and Pseudomonas, which often lives in plant roots, as well as the yeast ...
setting starting conditions #g is starting group #m is max number of iterations #t is time #u is the number of nodes #v is the number of groups g = m = t = 0 u = x (where x is the number of nodes in the model) v = y (where y is the number of groups in the model) #implement node iterator nodeChecker(): timeStep(): t = t + 1 nodeExecute(p): #p is the number of groups to execute over, in the interval 1 ,= g ,= v (p=1 is group 1, p=2 is group 1 and 2, ...) execute all nodes inside selected group(s) timeStep() printResults(): print results of execution of nodes at time of execution print state of unexecuted groups (minus current group(s)) #print the seedValue states of network before execution at time t, execute nodes in g nodeExecute(1) printResults() at time t+1, execute nodes in g and g+1 nodeExecute(2) printResults() ... at time t = m, execute nodes in group g, g+1 ... g+(u-1) nodeExecute(g+(u-1)) printResults() stop execution ...
to work on for our labs. The wires are hooked up to various logic gates which are hardwired into the board. For example, our first lab was to create a home alarm system using various logic gates to properly set off the alarm based on a set of conditions. It was a lot of fun to try to figure out not only how to do the lab, but to find the best solution. Since really, as engineers, we arent just trying to solve problems but are trying to solve them in the optimal manner. I think this class is really going to help with the idea of finding optimal solutions and the hands on nature of working with our circuit board seems like its going to be awesome.. If you cant tell from the pictures, my classes this semester are very focused on hands on learning. Im a big fan of this in computer science because its such a practical subject. Instead of just listening to lectures we are writing code and putting together systems. For me, that makes the experience way more fun and its great that the Viterbi ...
Design-and-Implementation-of-Phase-Frequency-Detector-Using-Different-Logic-Gates-in-CMOS-Process-Technology | Mini Projects | Electronics tutorial
The ninth edition of Scientia Pro Publica is up on Pleiotropy. Im quite proud because not only does it feature my colourful logic gates post, it also uses one of my pictures, or rather, one of my fellow working lab-rats pictures, of the colourful logic gates ...
A logic circuit generating method and apparatus generating logic circuits of a circuit system by minimizing the fan-out count of cells or cell macros constituting information specific to the circuit system. According to the method, a Boolean expression and the polarities of its input/output variables are input from a design master file of the apparatus. The Boolean expression is then transformed into a two-branch tree composed of nodes represented by the logical operators of that expression. In the two-branch tree, the nodes representing a parent and a child logical operator are converted into a single node, whereby a multiple-branch tree is generated. That is, a plurality of gates are connected to a single net, or signal line. A cell library is referenced so that cells are assigned initially to the multiple-branch tree thus obtained. The initial cell assignment is performed preferentially starting from the cell whose fan-out count is the largest. This
In the cellular automata simulation, the object under consideration is divided into small cells and the simulation is performed according to the local rule which is defined as the local relationship among cells. In this paper, the concept of cellular automata is applied to the design scheme of truss structures. First, truss elements are considered as the cells of the cellular automata and the local rule is derived from the optimization problem. The objective functions are defined to minimize the total weight of the structure and to obtain even stress distribution in the whole structure. The constraint conditions are introduced in order to define the local rule. The present method is applied to the design of the plane and the three-dimensional truss structures such as Schwedler and Lamella Domes. The convergence histories of the total weight and the mean and the maximum stresses are shown in order to discuss the property of the present method ...
Automata theory constitutes a cornerstone of mathematical computer science, and in particular finite automata have turned out to be very useful tools in many areas of discrete mathematics. Different models of automata in classical Chomsky hierarchy as well as corresponding grammars are considered and their generating power is compared. Basic undecidability results are proved.. ...
Dynamic DNA complexes are able to undergo multiple hybridization and dissociation events through a process called strand displacement. This unique property has facilitated the creation of programmable molecular detection systems and chemical logic gates encoded by nucleotide sequence. This work examines whether the ability to selective exchange oligonucleotides among different thermodynamically-stable DNA complexes can be harnessed to create a new class of imaging probes that permit fluorescent reporters to be sequentially activated (turned on) and erased (turned off). Here, dynamic DNA complexes detect a specific DNA-conjugated antibody and undergo strand displacement to liberate a quencher strand and activate a fluorescent reporter. Subsequently, incubation with an erasing complex allows the fluorophore to be stripped from the target strand, quenched, and washed away. This simple capability therefore allows the same fluorescent dyes to be used multiple times to detect different markers ...
EVE Online Salvaged Materials: Burned Logic Circuit | Autonomous field programmable holographic signal processor with embedded holographic data storage. Used in most modern computers, the ubiquitous AFPHSPEHDS is colloquially known as the Aphid. This name leads of course to many bad puns about bugs in the system.
On VLSI chips with a large number of logic gates and embedded storage arrays, data can be checked in the logic part by using two rails for each bit, who...
Loregic is a computational method integrating gene expression and regulatory network data, to characterize the logical cooperativity of regulatory factors. Loregic uses all 16 possible two-input-one-output logic gates (e.g. AND or XOR) to describe triplets of two factors regulating a common target, and finds the gate that best matches each triplets observed gene expression pattern across many conditions. Using human ENCODE ChIP-Seq and TCGA RNA-Seq data, we are able to demonstrate how Loregic characterizes complex circuits involving both proximally and distally regulating transcription factors (TFs) and also miRNAs ...
21) Parallel and distributed processing across many neuron-like units can lead to complex behaviors (Rumelhart & McClelland - 1986, OReilly - 1996). Pitts & McCullochprovided amazing insight into how brain computations take place. However, their two-layer perceptrons were limited. For instance, they could not implement the logic gate XOR (i.e., one but not both). An extra layer was added to solve this problem, but it became clear that the Pitts & McCulloch perceptrons could not learn anything requiring more than two layers.. Rumelhart solved this problem with two insights.. First, he implemented a non-linear sigmoid function (approximating a neuronal threshold), which turned out to be essential for the next insight.. Second, he developed an algorithm called backpropagation of error, which allows the output layer to propagate its error back across all the layers such that the error can be corrected in a distributed fashion. See P.L.s previous post on the topic for further ...
Advanced redstone circuits encompass mechanisms that require complicated redstone circuitry. They are usually composed of many simpler components, such as logic gates. For simpler mechanisms, see electronic mechanisms, wired traps, and Redstone. Hi! In Minecraft, several in-game systems can...
The essential problem is that software development is entirely unregulated. Anyone can call themselves a software engineer and they legally become one.. What you get is people with accountancy degrees, art history, etc deciding that theyve studied the wrong thing, and they see software development as a possibly lucrative second career option. This is wrong. They have no formal training (everything from binary or logic gates through OO & functional, on to CI/CD and devops) and they simply learn by doing. Theyve no proper understanding of encryption and not the first clue about computer security.. Why on earth would the doctors who specify what a pacemaker must do and what it is to achieve, the engineers who design it, and the manufacturers who build it all require certification and licencing, and yet the guy that knocks the software up that runs the thing could have been working in McDonalds a week earlier.. Software development should be a restricted profession with minimum educational ...
Using the model described above, we considered the situation where two TFs (TF1 and TF2) converge on a single gene promoter that we name GSU (gonadotropin subunit), a generic term used because this is likely to be the case for the αGSU, LHβ and FSHβ gonadotropin subunit genes, as it is for many other ERK and NFAT target genes [8,9,29-33]. We considered the possibility that TF1 is an ERK-activated TF and that TF2 is NFAT (parallel activation network topology) or that TF1 and TF2 are sequentially activated downstream of ERK (sequential activation network topology). We also tested three distinct logic gates for the nature of the action of TF1 and TF2 at the promoter [35]. The first is a CO-OPERATIVE gate that, in biological terms, could reflect the action of one TF to mediate the interaction between the other TF and the cells transcriptional machinery, or alternatively, the requirement of physical interaction between the two TFs to orientate distant promoter sites and bring them to close ...
Small RNAs (sRNAs) can operate as regulatory agents to control protein expression by interaction with the 5 untranslated region of the mRNA. We have developed a physicochemical framework, relying on base pair interaction energies, to design multi-state sRNA devices by solving an optimization problem with an objective function accounting for the stability of the transition and final intermolecular states. Contrary to the analysis of the reaction kinetics of an ensemble of sRNAs, we solve the inverse problem of finding sequences satisfying targeted reactions. We show here that our objective function correlates well with measured riboregulatory activity of a set of mutants. This has enabled the application of the methodology for an extended design of RNA devices with specified behavior, assuming different molecular interaction models based on Watson-Crick interaction. We designed several YES, NOT, AND, and OR logic gates, including the design of combinatorial riboregulators. In sum, our de novo approach
I also found this illuminates why building satisfactory taxonomy systems in databases (like those that power CMSs like WordPress) might be so difficult: Categories in our minds are essentially analogies, with varying degrees of complexity, but which grow and morph in meaning as we gain experience and learn. The edges are inherently fuzzy, and our mental hardware is optimized to make connections between them easily. In computer systems with fixed data structures, categories must have to be fixed, with clear hard yes/no lines, and (unless you have the benefit of complicated machine learning algorithms) connections between them must be intentionally and explicitly crafted by programmers. At first this appeared to me as a fundamental alienating difference between biological and machine minds: Fixed, binary thought, versus flexible, analog (with its delicious shares root with analogy) thought. But, I suppose our own minds are built up of their own (however elegant and complicated) logic gate hardware ...
Accurate characterization of promoter behavior is essential for the rational design of functional synthetic transcription networks such as logic gates and oscillators. However, transcription rates observed from promoters can vary significantly depending on the growth rate of host cells and the experimental and genetic context of measurement. Further, in vivo measurement methods must accommodate variation in translation, protein folding and maturation rates of reporter proteins, as well as metabolic load. The external factors affecting transcription activity may be considered extrinsic, and the goal of characterization should be to obtain quantitative measures of the intrinsic characteristics of promoters. We have developed a promoter characterization method that is based on a mathematical model for cell growth and reporter gene expression and exploits multiple in vivo measurements to compensate for variation due to extrinsic factors. First, we used optical density and fluorescent reporter gene ...
British scientists have successfully demonstrated that the logic gates used for processing information can be built of harmless gut bacteria and DNA.
OncoSenX is a late stage pre-clinical cancer company. OncoSenX targets solid tumors based on transcriptional activity using a unique lipid nanoparticle and plasmid DNA. The next generation in cancer therapies will be more targeted with less side effects. At OncoSenX we believe the battle against cancer should be fought with genetic information. Our treatment delivers a simple program that induces apoptosis in cancerous cells. Our approach is a less invasive, more precise intervention for this complex and devastating disease. Our system is comprised of two main components: An untargeted non-toxic lipid nanoparticle and a highly targeted DNA payload. DNA plasmids encode an inducible death protein under a promoter that is active in the target cell population. We are initially targeting cells that are transcriptionally active for p53. Cells are killed via apoptosis with caspase 9. We can use our DNA payload to effectively implement logic gates (IF / OR / AND). This allows us to precisely target cell ...
The author of this thesis is Malte Schmitz.. Regular linear temporal logic (RLTL) combines the advantages of linear temporal logic (LTL) and ω-regular expressions in a new logic. To use RLTL in practise an efficient translation from RLTL into automata is needed. In the context of this thesis such a translation was implemented as a scala program, which reads in RLTL formulas and translates them into finite alternating two-way parity au- tomata. In this thesis the used translation and its implementation will be described in detail.. ...
The new function FindTransientRepeat identifies the transient and repeated parts of a list. It can be used to investigate cellular automata.. Look at the rule 30 cellular automaton (CA). The Version 11 function RulePlot is a useful tool to find the associated transformation rules. ...
Inferring Genetic Regulatory Interactions with Bayesian Logic-Based Model: 10.4018/978-1-60566-685-3.ch005: This chapter describes the model of genetic regulatory interactions. The model has a Boolean logic semantics representing the cooperative influence of
A process automatically generating topology data for fabricating large scale integrated circuits. Technology data, a logic function description and logic circuit components are generated and input to a data processing system together with geometric dimension data descriptive of the basic elements of the logic circuit components. The geometric dimension data is assembled into a plurality of intermediate level geometric topology patterns under control of the logic function description and the intermediate level geometric topology patterns are assembled into a prime level geometric topology representative of the logic function description. The logic circuit components are merged with the prime level geometric topology to produce a grid array to be fabricated into a large scale integrated circuit.
Pheromone-based internally optimizing resource gathering network simulation using automata inspired by ants. - sampottinger/simple_ant
These lectures describe a few dynamical properties of some statistical mechanics systems such as spin models, automata, neural networks. Two aspects will be mostly discussed: the multivalley...
Technology scaling poses an increasing challenge to the reliability of digital circuits. Hardware redundancy solutions, such as triple modular redundancy (TMR), produce very high area overhead, so partial redundancy is often used to reduce the overheads. Approximate logic circuits provide a general framework for optimized mitigation of errors arising from a broad class of failure mechanisms, including transient, intermittent, and permanent failures. However, generating an optimal redundant logic circuit that is able to mask the faults with the highest probability while minimizing the area overheads is a challenging problem. In this study, we propose and compare two new approaches to generate approximate logic circuits to be used in a TMR schema. The probabilistic approach approximates a circuit in a greedy manner based on a probabilistic estimation of the error. The evolutionary approach can provide radically different solutions that are hard to reach by other methods. By combining these two ...
but the normalized value of SMART attribute 177, wear leveling count, is the percentage of rated life left in the NAND cells. Edit: I see now that the author of one of the programs has said that the drive life is now based on 0xB1, wear leveling count, instead of some others. 0xB1 in hex is 177 in decimal, so it is the attribute I was referring to above. I would agree that this is a more fitting estimate of the drives remaining rated life. Id keep using it at 59% if it were mine.. SSDs have a rated number of write cycles they can endure, but reaching that point doesnt mean the NAND cells are actually dead. A Samsung 840 Pro was the torture test champion in TechReports torture test, where they wrote to the drives continuously until they failed. The drive made it to about 2 petabytes before it failed (2,000 TB)! It was rated for far less life than that.. If the drive has had uncorrectable errors (attribute 187), that means there was a hard failure in one or more NAND cells that could not be ...
This online tool also supports PyMOL and UCSF Chimera plugin for molecular visualization. 4.1 Protein science, from an amino ... Computer Atlas of Surface Topography of Proteins (CASTp) aims to provide comprehensive and detailed quantitative ... and by molecular surface model (Connolly surface), all calculated analytically. The core algorithm helps in finding the pocket ... Journal of Molecular Biology. 55 (3): 379-IN4. doi:10.1016/0022-2836(71)90324-x. ISSN 0022-2836. PMID 5551392. Connolly, M. ( ...
Mountain View, California: Computer History Museum. p. 26. Texas Instruments (1961). A Molecular Electronic Computer (PDF). ... 1961 Semiconductor Network Computer (Molecular Electronic Computer, Mol-E-Com), first monolithic integrated circuit general ... "Early Honeywell Mini-Computers". Retrieved March 20, 2019. "Model 480 general purpose desk-top computer". Computers and ... Computer Design. Computer Design Publishing Corporation. 1962. p. 35. "Fabrication of IC devices". Retrieved 2019 ...
Molecular Speculations on Global Abundance. MIT Press. pp. 147-160. ISBN 978-0-262-03237-7. Retrieved 2007-02-18. "VividQ Home ... Ultimately, computer-generated holography might serve all the roles of current computer-generated imagery: holographic computer ... 1992). "Computer-generated holograms: A simplified ray-tracing approach". Computers in Physics. 6 (4): 389-393. Bibcode: ... Slinger; C. Cameron; M. Stanley (Aug 2005), "Computer-Generated Holography as a Generic Display Technology", Computer, 38 (8): ...
"About the CCMB". Center for Computational Molecular Biology. Retrieved 18 August 2012. Rivest, Ronald L. (1990). "Cryptology". ... Quantum computers are different from digital computers based on transistors. Whereas digital computers require data to be ... which is a subfield of computer science and computer engineering using bioengineering and biology to build computers, but is ... Innovations in Theoretical Computer Science (ITCS) Mathematical Foundations of Computer Science (MFCS) International Computer ...
... molecular biology, genetics, genomics, computer science, and evolution. Computational biology is different from biological ... computer software is all information processed by computer systems, programs and data. Computer software includes computer ... computer program Is a collection of instructions that can be executed by a computer to perform a specific task. computer ... computer graphics Pictures and films created using computers. Usually, the term refers to computer-generated image data created ...
Constant-temperature molecular dynamics (Nose thermostat). Variable cell dynamics (Parrinello-Rahman). Spin polarized ... Quantum chemistry computer programs García, Alberto; Papior, Nick; Akhtar, Arsalan; Artacho, Emilio; Blum, Volker; Bosoni, ... SIESTA (Spanish Initiative for Electronic Simulations with Thousands of Atoms) is an original method and its computer program ... Hydration strongly affects the molecular and electronic structure of membrane phospholipids J. Chem. Phys. 136, 114709 (2012) [ ...
... "molecular computer" with a 300-bit memory based on the #587 ICs of Kilby. Harvey Kreygon packed this computer into a volume of ... "ARTICLES: Molecular Electronics - An Introduction" (PDF). Computers and Automation. XI (3): 10-12, 14. Mar 1962. Retrieved 2020 ... "1962 - Aerospace systems are first the applications for ICs in computers". Computer History Museum. Archived from the original ... sfn error: no target: CITEREFLojek2011 (help) "Computer Pioneers - James L. Buie". IEEE Computer Society. Retrieved 25 May 2020 ...
CP2K - Open-source ab-initio molecular dynamics program. DWSIM - an open-source CAPE-OPEN compliant chemical process simulator ... The following is a list of notable computer simulation software. Advanced Simulation Library - open-source hardware accelerated ... Repast - agent-based modeling and simulation platform with versions for individual workstations and high performance computer ... Ship Simulator - a vehicle simulation computer game by VSTEP which simulates maneuvering various ships in different ...
Computer Modeling in Engineering & Sciences Computers, Materials, & Continua Molecular & Cellular Biomechanics Advances in ... He founded the journals Computer Modeling in Engineering & Sciences (2000); Computers, Materials, & Continua (2004); Molecular ... Six out of the ten most highly cited papers in the journal CMES: Computer Modeling in Engineering & Sciences from 1999 to 2014 ... Atluri, S.N. (2005). Methods of Computer Modeling in Engineering & the Sciences. Tech Science Press. ISBN 0-9657001-9-4. Atluri ...
Guha R, Mohajerani F, Collins M, Ghosh S, Sen A, Velegol D (November 2017). "Chemotaxis of Molecular Dyes in Polymer Gradients ... Computers & Mathematics with Applications. 71 (11): 2466-2478. doi:10.1016/j.camwa.2015.12.019. Szurmant H, Ordal GW (June 2004 ... Zhong, Maohua; Yan, Huimin; Li, Yaoming (October 2017). "Flagellin: a unique microbe-associated molecular pattern and a multi- ... Ghose, Debraj; Lew, Daniel (1 May 2020). "Mechanistic insights into actin-driven polarity site movement in yeast". Molecular ...
... for example in molecular dynamics, for VLSI circuit simulation, and in computer graphics. They are also applied in the context ... Michels, Dominik L.; Desbrun, Mathieu (2015). "A Semi-analytical Approach to Molecular Dynamics". Journal of Computational ... ISBN 978-3-319-09062-7. Luan, Vu Thai; Ostermann, Alexander (2016). "Parallel exponential Rosenbrock methods". Computers and ... IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems. 32 (8): 1180-1193. doi:10.1109/TCAD.2012.2189396 ...
Molecular Biosciences; Biosciences; Physics and Astronomy; Politics; Sport; Social Policy and Administration. Bath was ranked ... Computer Science; Electronic and Electrical engineering; Mechanical Engineering (IMechE accredited); Mathematics, Statistics ... performance and rehearsal studios 1 West refurbishment to add new learning and research facilities and computer laboratories ...
Computer Chem. 1: 171-175. I. Gutman; B. Ruscic; N. Trinajstić; C.F. Wilcox Jr. (1975). "Graph theory and molecular orbitals. ... Computer Chem. 1: 171-175. I. Gutman; M. Milun; N. Trinajstić (1977). "Graph Theory and Molecular Orbitals. XIX. Non-Parametric ... In quantum chemistry he worked on semi-empirical molecular orbital theory and settling conjugated-circuit model on a firm ... He wrote the first monograph on chemical graph theory and introduced several molecular descriptors such as 3-dimensional Wiener ...
Computer Genetics. A special issue on computational molecular biology // BioSystems. 1993. V. 30. Gelfand M. S., Mironov A. A ... Gelfand M. S. Computer prediction of the exon-intron structure of mammalian pre-mRNAs // Nucleic Acids Research. 1990. Y. 18. N ... Gelfand M. S. Statistical analysis and prediction of the exonic structure of human genes // Journal of Molecular Evolution. ... Molecular biologists, Russian activists, 1963 births, Living people, Russian activists against the 2022 Russian invasion of ...
Molecular and cellular biology ; Computer science ; Physiology ; Chemistry ; Biochemistry ; Microbiology ; Nine practical work ...
In 2000, there were sixteen sections: Agricultural Science; Anthropology & Archaeology; Biochemistry, Biophysics & Molecular ... including Computer science); Material science; Mathematical science (including Statistics); Medical science (including ... Biology; Botany; Chemistry; Computer science; Earth system science; Engineering science; Material science; Mathematics; Medical ... Physiology); New Biology (including Biochemistry, Biophysics & Molecular Biology; and Biotechnology); Physical science; and ...
Computer Chem. 1: 171-175. I. Gutman; B. Ruscic; N. Trinajstić; C.F. Wilcox Jr. (1975). "Graph theory and molecular orbitals. ... A. Graovac; I. Gutman; N. Trinajstić; T. Živković (1972). "Graph theory and molecular orbitals: Application of Sachs theorem". ... I. Gutman; M. Milun; N. Trinajstić (1977). "Graph Theory and Molecular Orbitals. XIX. Non-Parametric Resonance Energies of ... I. Gutman (1994). "Selected properties of the Schultz molecular topological index". J. Chem. Inf. Comput. Sci. 34 (5): 1087- ...
... computer simulation using molecular modeling for drug discovery. computer simulation to model viral infection in mammalian ... Computer graphics can be used to display the results of a computer simulation. Animations can be used to experience a ... Computer simulation is the process of mathematical modelling, performed on a computer, which is designed to predict the ... Computer simulations are realized by running computer programs that can be either small, running almost instantly on small ...
In: Computers and Standards 1, 1982. 1983. "The Structuring Capabilities of the Molecular Data Model." In; Entity-Relationship ... American computer scientists, Database researchers, Fellows of the British Computer Society, American software engineers, ... In 2002 he gave a lecture at the Computer History Museum on assembling the Integrated Data Store, and an oral history for the ... There he was first exposed to and used fire control computers for aiming 90 mm guns. After his discharge in 1946 he attended ...
... (MD) is a computer simulation method for analyzing the physical movements of atoms and molecules. The atoms ... Journal of Computer-aided Molecular Design. 18 (1): 13-22. Bibcode:2004JCAMD..18...13P. doi:10.1023/b:jcam.0000022559.72848.1c ... Journal of Computer-aided Molecular Design. 30 (12): 1149-1163. Bibcode:2016JCAMD..30.1149H. doi:10.1007/s10822-016-9984-2. ... Materials modelling and computer simulation codes A few tips on molecular dynamics Movie of MD simulation of ...
... molecular dynamics simulation at realistic limit" (PDF). Computer Physics Communications. 146 (1): 30. Bibcode:2002CoPhC.146... ... Nordlund, K. (1995). "Molecular dynamics simulation of ion ranges in the 1-100 keV energy range". Computational Materials ... This is a list of computer programs that are used to model nanostructures at the levels of classical mechanics and quantum ... Furiousatoms - a powerful software for molecular modelling and visualization - a powerful platform for nanoscale ...
Evans, Denis J.; Morriss, Gary P. (1984). "Non-Newtonian molecular dynamics". Computer Physics Reports. North-Holland. 1 (16): ... "SklogWiki Non-equilibrium Molecular Dynamics". Retrieved 4 May 2020. "Statistical Mechanics of Nonequilibrium Liquids, Authored ... computer simulation algorithms for nonequilibrium systems, the relation of the intermolecular potential function to macroscopic ... and his development of algorithms for nonequilibrium molecular dynamics simulations. Evans has over 350 publications on ...
Danos V, Laneve C (2004). "Formal molecular biology". Theoretical Computer Science. 325: 69-110. doi:10.1016/j.tcs.2004.03.065 ... Lecture Notes in Computer Science. Lecture Notes in Computer Science. 6501: 240-256. doi:10.1007/978-3-642-18123-8_19. ISBN 978 ... A molecular species with several of those features can therefore exist in a large number of possible states. For instance, it ... When used in this way, a slot is a placeholder for a subunit or a molecular component of a complex, and the state of the slot ...
This is a list of computer programs that use Monte Carlo methods for molecular modeling. Abalone classical Hybrid MC BOSS ... Towhee) (16 September 2013). "MCCCS Towhee: a tool for Monte Carlo molecular simulation". Molecular Simulation. 39 (14-15): ... Molecular modelling software, Monte Carlo molecular modelling software). ... A molecular simulation tool for thermodynamic properties, release 3.0". Computer Physics Communications. 221: 343-351. Bibcode: ...
Molecular Electronic Computer brochure , 102646283 , Computer History Museum. Texas Instruments ... Donald Davies (2001), "A Historical Study of the Beginnings of Packet Switching", Computer Journal, British Computer Society[ ... Information revolution See 6502 microprocessor history "Computer Pioneers - Christopher Strachey". IEEE Computer Society. ... A computer history site; the present article is a modified version of his timeline, used with permission. (All articles with ...
A VMD interface for analyzing metadynamics and molecular dynamics simulations". Computer Physics Communications. 183 (1): 203- ... A portable plugin for free-energy calculations with molecular dynamics". Computer Physics Communications. 180 (10): 1961-1972. ... In addition, PLUMED can be used as a standalone tool for analysis of molecular dynamics trajectories. A graphical user ... Official website METAGUI v t e (Official website different in Wikidata and Wikipedia, Molecular dynamics software, ...
"Strong scaling of general-purpose molecular dynamics simulations on GPUs". Computer Physics Communications. 192: 97-107. arXiv: ... "Using Multiple Graphics Cards as a General Purpose Parallel Computer: Applications to Computer Vision", Proceedings of the 17th ... Mediated Reality Using Computer Graphics Hardware for Computer Vision (PDF). Proceedings of the International Symposium on ... Computer video cards are produced by various vendors, such as Nvidia, AMD. Cards from such vendors differ on implementing data- ...
Quantemol Morgan, Lesley A.; Tennyson, Jonathan; Gillan, Charles J. (1998). "The UK molecular R-matrix codes". Computer Physics ... The UK Molecular R-Matrix codes are a set of software routines used to calculate the effects of collision of electrons with ... The UK Molecular R-Matrix codes were developed by the Collaborative Computational Project Q (CCPQ). The CCPQ and CCP2 have ... Quantemol-N (QN) is software that allows the UK molecular R-matrix codes, which is used to model electron-polyatomic molecule ...
... computer Carbon nanotubes in photovoltaics Colossal carbon tube Diamond nanothread Filamentous carbon Molecular ... Wang M, Li CM (January 2010). "An oscillator in a carbon peapod controllable by an external electric field: a molecular ... The concept of representative volume element (RVE) is used to determine the appropriate size and configuration of computer ... Simonite T. "IBM Expects Nanotube Transistor Computer Chips Ready Soon After 2020". MIT Technology Review. Thomas DJ (June 2018 ...
Computer sciences 1. Mathematics 2. Astronomy and physics 3. Chemistry 4. Engineering 5. Earth science and environmental ... science 6. Biochemistry and molecular cell biology 7. Microbiology, immunology and developmental biology 8. Anatomy, physiology ...
Neese, Frank (2009). "Prediction of molecular properties and molecular spectroscopy with density functional theory: From ... He is lead author of the ORCA quantum chemistry computer program. His methods have been applied to a range of problems in ... "International Academy of Quantum Molecular Science". Retrieved 16 December 2021. Website at the Max-Planck- ... Neese, Frank (2012). "The ORCA program system". WIREs Computational Molecular Science. 2: 73-78. doi:10.1002/wcms.81. S2CID ...
While early computers in the 1970s were only able to compute diffraction data with the more simple Fraunhofer approximation, ... Mie scattering (sometimes referred to as a non-molecular scattering or aerosol particle scattering) takes place in the lower ... Mie solutions are implemented in a number of programs written in different computer languages such as Fortran, MATLAB, and ... Department of Electrical and Computer Engineering, The University of Michigan, Ann Arbor, Michigan (1972) Kerker, M.; Wang, D.- ...
Lecture Notes in Computer Science. Vol. 5912. pp. 667-684. doi:10.1007/978-3-642-10366-7_39. ISBN 978-3-642-10365-0. Salzberg, ... Burge, Chris; Karlin, Samuel (1997). "Prediction of Complete Gene Structures in Human Genomic DNA". Journal of Molecular ... Berkeley, CA: International Computer Science Institute. pp. 7-13. Rabiner, Lawrence (February 1989). "A Tutorial on Hidden ... Journal of Molecular Biology. 190 (2): 159-65. doi:10.1016/0022-2836(86)90289-5. PMID 3641921. Durbin, Richard (23 April 1998 ...
Palumbi's research interests include studying evolution and change using molecular genetics techniques, marine population ... and was developed over a period of four years by a team of scientists whose work was visualised through computer animation. ...
Depending upon the age and sanctity (foulness) of the garment, effects could range from burns to total molecular breakdown ( ... it is an irony the game collapsed at the dawn of personal computers and the internet, which would have greatly eased ...
His plan is opposed by Computer Supreme and its puppet ruler Doctor X, who doesn't want anyone to leave the city. 38. Gene, ... the doctor's legs and rejoin the two pieces before they are damaged because the slightest bobo will modify the body's molecular ... X's "perfect" Mindnet computer is given control of Technopolis and tasked with eliminating inefficiencies promptly expels all ... French computer-animated television series, KidsClick, Television about fairies and sprites, Television about magic, Witchcraft ...
The Environmental Molecular Sciences Laboratory (EMSL) is a U.S. Department of Energy national scientific user facility. EMSL ... to advance visualization research using computer technology to enable humans to visually synthesize and derive insight from ... "Environmental Molecular Sciences Laboratory , PNNL". Retrieved 2019-04-12. Schill, SR. 2008. "PNNL, WSU partner ... "The Role of Pendant Bases in Molecular Catalysts for H2 Oxidation and Production." Comptes Rendus Chimie 11(8):805-817. Basic ...
Combined QM and molecular mechanics calculations for systems such as proteins and molecular clusters. The NEMO procedure for ... MOLCAS 7.2 has been independently reviewed at JACS computer software reviews. Ab initio Hartree-Fock (HF), Density functional ... Tully Surface Hopping Molecular Dynamics Method for localization and characterization of conical intersections and seams MOLCAS ... ". "portable Molecular viewer GV". MOLCAS homepage OpenMolcas project page (Articles with short description, Short description ...
The computer network including Internet has been opened for medical education, Long-distance Medical Education, E-mail, ... In 2009, the Center for Molecular Medicine of Karolinska University Hospital and Tianjin Medical University announced an ... agreement to build the Sino-Swedish Center for Molecular Medicine. Tianjin Medical University has also more than 50 partner ...
Due to its small size and complex morphology, it has become an ideal model for the study of many processes in molecular biology ... Hoeprich, Stephen; Guo, Peixuan (2002-06-07). "Computer Modeling of Three-dimensional Structure of DNA-packaging RNA (pRNA) ... Bacteriophage : genetics and molecular biology. Stephen Mc Grath, Douwe van Sinderen. Norfolk, UK: Caister Academic Press. 2007 ... Molecular Cell. 2 (1): 149-155. doi:10.1016/S1097-2765(00)80124-0. ISSN 1097-2765. PMID 9702202. Simpson, Alan A.; Tao, Yizhi; ...
... a computer programme This disambiguation page lists articles associated with the title Smarts. If an internal link led you here ... a line notation language for specifying molecular query patterns Smarts Mountain, a mountain in New Hampshire "Smarts", a slang ...
She added her courtesy appointment in electrical and computer engineering in 2013. She was named associate dean in 2019. Hogben ... University of Iowa Department of Molecular Physiology and Biophysics, retrieved 2019-09-03 Mark Hunacek, Iowa State University ... of electrical and computer engineering at Iowa State, associate dean for graduate studies and faculty development at Iowa State ...
She was the first girl to take AP Computer Science at her high school. She attended Simmons College to study molecular biology ... Moussouris was interested in computers at a young age and learned to program in BASIC on a Commodore 64 that her mother bought ... She moved to California to work as a Linux developer at Turbolinux and started their computer security response program. She ... Katie Moussouris is an American computer security researcher, entrepreneur, and pioneer in vulnerability disclosure, and is ...
... 's psionic ability to rearrange the molecular structure of objects is far greater than that of any other Eternal; the ... The Dane Whitman meanwhile, discovered by computer analysis that Proctor was a version of himself from a different reality. ... her of it by molecular disintegration, killing her. Sprite, who had learned of Sersi's relations with the Black Knight, ... She has the ability to alter molecular and atomic structures of all matter including living organisms. However, she has ...
... author of the first computer science textbook; helped found the Stanford University Department of Computer Science William ... molecular biologist, professor at Harvard Medical School David Berson, neurobiologist, professor at Brown University Jean ... computer enthusiast Donald Berwick, former Administrator of the Centers for Medicare and Medicaid Services; candidate for ...
... of NAMD at UIUC built on the work of Schulten's students in Munich to build a custom parallel computer optimized for molecular ... He used petascale computers, and planned to use exa-scale computers, to model atomic-scale bio-chemical processes. His work ... we need to understand life at the molecular level and to know how all the molecular components work together like clockwork. ... Schulten partnered with computer scientists Robert Skeel, and Laxmikant V. Kale ("Sanjay" Kale) on a five-year grant from the ...
QCA have attracted a lot of attention as a result of its extremely small feature size (at the molecular or even atomic scale) ... See also (quant-ph) R. Feynman, "Simulating physics with computers", Int. J. Theor. Phys. 21, 1982: pp. 467-488. D. Deutsch, " ... 36th Annual Symposium on Foundations of Computer Science (Milwaukee, WI, 1995), Los Alamitos, CA: IEEE Comput. Soc. Press, pp. ... W. van Dam, "Quantum cellular automata", Master Thesis, Computer Science Nijmegen, Summer 1996. C. Dürr and M. Santha, "A ...
... Company web site Parallel NFS (Computer storage companies, Computer companies of the United States, Computer companies ... It delivers exceptional performance for high performance data analytics, complex modeling and simulation, molecular imaging ... Panasas is a computer data storage product company and is headquartered in San Jose, California. Panasas received seed funding ...
... mathematician and computer scientist Roger Sanders Albert Schatz (scientist) Oliver Smithies James Dewey Watson - molecular ... computer scientist Freeman Dyson - theoretical physicist and mathematician F. Duncan M. Haldane Oliver Hart (economist) George ...
To carry out these studies, von Neumann decided to use electronic computers: ENIAC at Aberdeen, a new computer, MANIAC, at ... Ulam's work on non-Euclidean distance metrics in the context of molecular biology made a significant contribution to sequence ... As computers improved in speed and programmability, these methods became more useful. In particular, many Monte Carlo ... When Ulam returned to Los Alamos, his attention turned away from weapon design and toward the use of computers to investigate ...
... computer science Pinar Heggernes, computer science Knut Olav Åmås, journalist Erna Solberg, Prime Minister of Norway Karl Ove ... Sars International Centre for Marine Molecular Biology K.G. Jebsen Centre for Deep Sea Research Bjerknes Centre for Climate ...
1860-1929), organic chemist Max Perutz (1914-2002), x-ray crystallographer and molecular biologist George Perry, 19th century ... computer scientist Humphry Davy (1778-1829), chemist and inventor Richard Dawkins (born 1941), ethologist and evolutionary ... molecular biologist Andrew Crosse (1784-1855), pioneer in the study of electricity Alexander Crum Brown (1838-1922), organic ... computer scientist Edmond Halley (1656-1742), astronomer Frances Mary Hamer (1894-1980), chemist William Donald Hamilton (1936- ...
Guild S-100, an electric guitar Lenovo IdeaPad S100, a netbook computer Qtek S100, a mobile phone Schiebel Camcopter S-100, an ... low-molecular-weight proteins in vertebrates The road number used in the Netherlands for inner-city ring roads AVE Class 100, ... S100 or S-100 may refer to: S-100 bus, an early computer bus S-100, an International Hydrographic Organization standard S100 ...
... able to measure molecular concentrations in the parts-per-1012 (ppt) level. Due to the high power densities achievable by ... tablet computers, and LED TVs. A detailed list of industrial and commercial laser applications includes: Laser cutting Laser ...
... using sophisticated molecular biology techniques. During medical school, he was awarded a NASA graduate student fellowship and ... for everything from drones and computer games to VR and surgical robotics. Boy Scouts of America Eagle Scout (1977) National ...
... a computer lab conversion to double-sided printing, the distribution of green living guides, as well as the creation of a ... Molecular biologist Harvey Lodish (1962) Architect Graham Gund (1963) Cartoonist and "Zits" co-creator Jim Borgman (1976) Co- ...
... mission computers, cameras and other instruments. FPGAs and SoCs Flash-based FPGAs and SoCs from 5K to 150KLUTs Space-grade ... "Molecular packaging of integrated circuits has been suggested by Microsemiconductor Corp. This would involve the same process ... the company said it planned to sell or close 10 subsidiaries not related to its core business of manufacturing computer chips ...
... invented Java computer language Chris Haney (1950-2010) - co-inventor of Trivial Pursuit Sam Jacks (1915-1975) - inventor of ... molecular biologist, winner of Nobel Prize in chemistry Brenda Andrews (born 1957) - academic, researcher and biologist ... molecular geneticist Cynthia Grant - soil fertility and crop nutrition specialist Donald O. Hebb FRS (1904-1985) - ... Nobel Prize winner in chemistry for molecular spectroscopy James Hillier OC (1915-2007) - inventor of the electron microscope ...
He received a BS in Computer Science from Pace University, a Masters in Computer Science from North Carolina State University, ... other maladies of the eye Gualberto Ruaño is a pioneer in the field of personalized medicine and the inventor of molecular ... William G. Pagán is an IBM-recognized Master Inventor, a member of the NC State University Computer Science Alumni Hall of Fame ... He received a BS and MS in Computer Engineering from University of Puerto Rico, and a Ph.D. with a Cybersecurity specialization ...
Machine hearing, also known as machine listening or computer audition, is the ability of a computer or machine to take in and ... molecular, atomic level, indiscernible and identical. The end goal of machine perception is to give machines the ability to see ... Turk, Matthew (2000). "Perceptive Media: Machine Perception and Human Computer Interaction" (PDF). Chinese Journal of Computers ... have allowed computers to take in sensory input in a way similar to humans. Machine perception allows the computer to use this ...
Specialisation: Molecular ChemistrySpecialisation: Molecular Chemistry *Description of Molecular Chemistry *Programme of ... Specialisation: Molecular ChemistrySpecialisation: Molecular Chemistry *Description of Molecular Chemistry *Programme of ... Mathematics for Computer Scientists and Molecular Scientists *Mathematics for Physicists *Medical Biology *Neuroscience for ... Mathematics for Computer Scientists and Molecular Scientists *Mathematics for Physicists *Medical Biology *Neuroscience for ...
3D computer animations of Burgess Shale fossils *Are birds really dinosaurs? *Lambert & Ostroms The Ultimate Dinosaur Book ... Another excellent book is Molecular Biology Made Simple and Fun by David Clark and Lonnie Russell, ISBN 0962742295 (order from ... The typical "introductory" molecular biology textbook weighs in at 1000+ pages, and assumes some background in biology ... The purpose of this course is to provide a serious introduction to the core elements of molecular biology using a unique, ...
NEWS: QuantumBio Reveals Game-Changing Crystallography Refinement Method in Journal of Computer-Aided Molecular Design. ... NEWS: QuantumBio Reveals Game-Changing Crystallography Refinement Method in Journal of Computer-Aided Molecular Design ... The article is currently available under Open Access and will be published in a special issue of the Journal of Computer- ... EVENT: QuantumBio to sponsor 2021 Computer Aided Drug Design Gordon Research Conference in Mt. Snow, VT November 7, 2021 ...
John Kendrew First Applies an Electronic Computer to Molecular or Structural Biology to Calculate Structure Factors of ... John Kendrew First Applies an Electronic Computer to Molecular or Structural Biology to Calculate Structure Factors of ... At the second English computer conference held in Manchester from July 9-12, 1951 computer scientist John Makepiece Bennett and ... In 1962 Kendrew received the Nobel Prize in chemistry for his discovery of the 3-dimensional molecular structure of myoglobin, ...
Snails carrying tiny computers solve survival mystery. Animals * Rhythm or blues: Rock hyrax males who flow on beat in their ... Molecular Möbius strip: chemists make a geometric anomaly from atoms. A new molecules twists and turns are a first for nano- ... "Just like belts we use every day, we imagined what would happen to our molecular belt when tightened with a twist. Its ... "The key to the success in the actual synthesis was our molecular design and detailed examination of the reaction conditions," ...
... Contemporary Computer Assisted Approaches To ... access you for playing a Contemporary Computer Assisted Approaches! Your Contemporary Computer Assisted Approaches to Molecular ... An Converted Contemporary Computer Assisted Approaches to Molecular works was. Please access the basis not to lift the course. ... Another Contemporary Computer Assisted Approaches to Molecular to tell Understanding this set in the flow provides to refer ...
Whatever Happened to the Molecular Computer? Why the tantalizing promise of replacing silicon with molecular components has yet ...
Molecular Diagnostic. *. Mobility Aid Technologies. *. Microfluids & MEMS. *. Non-Invasive monitoring. *. Bioimplants - ... Military Computers Market by Computer Type (Rugged (Wearable, Portable), Embedded (Flight Control, Utility Control, Fire ... In October 2017, the company launched a new family of rugged pre-integrated avionics computers. The new computer system ... Zebra Technologies Corp., through its Enterprise business segment, offers ruggedized handheld computers, wearable computers, ...
The Sci-Fi Dream of a Molecular Computer Is Getting More Real. Chemists have long conceptualized tiny machines that could ... This Computer Is Made of Fabric. The jacket can raise and lower its own hood-without chips or batteries-and might one day help ...
Computer Model Uses Genetics, Health Data to Predict Mental Disorders A new model in JAMA Psychiatry finds combining genetic ... Molecular Assemblies is not done raising money for its Series A, as the company expects to raise as much as $18 million to $20 ... Molecular Assemblies is one of several companies here, joined by Twist Bioscience and SGI DNA, among others, who are working on ... Though Molecular Assemblies cant yet create 150 bp-long constructs at the yield and purity that it wants, CEO Michael Kamdar ...
2 with a inevitable download Computer Compilation of Molecular Weights and Percentage Compositions for Organic and passion page ... The download Computer Compilation of Molecular Weights and Percentage Compositions for of the magic health writes broad - if ... 0 download Computer Compilation of Molecular Weights and Percentage Compositions for; southeastern officials may lead. workers ... interested download Computer Compilation of Molecular Weights and Percentage Compositions for Organic Compounds 1969 delivers ...
The Sci-Fi Dream of a Molecular Computer Is Getting More Real. Leave a Comment / sport / By admin ... Its also not yet possible to "write" information using a molecular computer, which is what would be required to actually ... "The way the molecular machines have been designed is really intricate, and really nice," says Lee Cronin, a chemist at the ... Then, if you shine light at the molecular machine while it reads, each of the three contortions will twist that light in a ...
3. Proteins, crystals and computers. 4. Televisual language. Part II. Building Molecular Biology:. 5. Locating the double helix ... Molecular biology has come to dominate our perceptions of life, health and disease. In the decades following World War II, the ... Designs for Life is a major contribution both to the history of molecular biology, and to the history of science and technology ... Soraya de Chadarevians important study was the first to examine the creation and expansion of molecular biology through the ...
Computational modeling revealed molecular interactions involved in ligand binding and further highlighted interactions that ... High-potency olfactory receptor agonists discovered by virtual high-throughput screening: molecular probes for receptor ... Computer-Aided Design * Drug Evaluation, Preclinical / methods* * Goldfish * Humans * Ligands* * Models, Molecular ...
JavaScript isnt enabled in your browser, so this file cant be opened. Enable and reload ...
Computer-aided drug design comprises computational methods and resources that are used to facilitate the design and discovery ...
Scientists Build the First Crucial Components of a Molecular Computer. November 7, 2022. ... The end result as Werner sees it is an experience more like interacting with the real world, in which our computers adapt to us ... The wearable AR devices weve seen are yet a bit clunky, and they arent likely to sweep away todays computer interfaces right ... This is the birth of the next great computer interface, according to Werner. But it doesnt actually have a name yet. ...
Researchers develop the first DNA computer capable of pinpointing several antibodies in the blood and carrying through ... Researchers develop the first DNA computer capable of pinpointing several antibodies in the blood and carrying through ... Using a combination of DNA, biochemistry, and molecular biology hardware, researchers seek to use DNA sequencing for data ... The goal of this new field is to create nano-computers using DNA instead of mechanical parts. The resulting machines would be ...
Michael Levitt prefers a different medium the 1 s and 0 s of computer science. For almost 40 years, he has been creating ... dynamic computer models of proteins, nucleic acids and other macromolecules and now he is tackling one of his most ambitious ... Thats where computers come in.. "If you have certain atoms sitting in certain locations and if you know something about the ... "You need a lot of biological background and intuition to know if what you are doing makes any sense at all or if it is computer ...
Effects of probiotics and antibiotics on the intestinal homeostasis in a computer controlled model of the large intestine ... Molecular Dynamics of the Human Intestinal Microbiota During Antibiotic Perturbation and Resilience ... from generic information on biological systems at different functional and cellular levels to high-throughput molecular data ...
Molecular docking additionally provided an interesting hypothesis on how the different mixture components may favor binding of ... were studied through a molecular dynamics approach to understand how ethambutol and arginine could be stabilized by the ... were studied through a molecular dynamics approach to understand how ethambutol and arginine could be stabilized by the ... Computer Phys. Commun. 184, 2641-2650. doi:10.1016/j.cpc.2013.06.003 ...
Senior Computer Scientist. Giulia Galli Joint Appointment/Center for Molecular Engineering (CME) ... The Center for Molecular Engineering - a partner organization to the Pritzker School of Molecular Engineering at The University ... The mission of the Center for Molecular Engineering (CME) is to translate advances in materials science, physics, chemistry, ...
All the latest science news about molecular and cellular biology from ... Teaching machines to see: Professor reverse-engineers human vision for computers. ( do we know if were looking at ... Molecular motion in detail: Scientists high-res images illuminate binding process. In a critical breakthrough in unraveling ... remove waste from cells, a class of membrane-sculpting proteins create vesicles-molecular trash bags-that carry ...
Computer Programming. * Molecular Biology. * Genetics. If you think Biomedical Engineering is something you may wish to pursue ...
molecular biology. *chemistry. *mathematics. Bioinformatics merges computer and information science with the study of genetic ... Understand the theory and application of biomedical informatics focused around the core areas of computer science, medicine, ...
The Sci-Fi Dream of a Molecular Computer Is Getting More Real. Chemists have long conceptualized tiny machines that could ... Quantum computers, once thought to be superior to classical computers, increasingly are being seen as yet another accelerator ...
  • The sequencing of the human genome, and the drive to understand its meaning, have created an overwhelming need for quantitatively trained scientists and engineers familiar with the details of molecular biology. (
  • The typical "introductory" molecular biology textbook weighs in at 1000+ pages, and assumes some background in biology generally. (
  • Quantitative scientists wishing to explore molecular biology encounter their first significant obstacle when they first visit the bookstore. (
  • The purpose of this course is to provide a serious introduction to the core elements of molecular biology using a unique, engaging approach that assumes a quantitative background, not a biological one. (
  • As you will see, despite the radical differences between biology and, say, physics, there is a great deal of scientific rigor and creativity in the history and practice of molecular biology. (
  • There are many excellent textbooks on molecular biology, but none that covers the breadth of topics we will attempt, nor one that is both rigorous and comprehensible to the non-specialist. (
  • Another excellent book is Molecular Biology Made Simple and Fun by David Clark and Lonnie Russell, ISBN 0962742295 ( order from Amazon ). (
  • This was the first application of an electronic computer to computational biology or structural biology. (
  • The Department of Molecular Biology and Genetics (MBG) is situated in Thrace, at the crossroad between Europe and Asia. (
  • It is the only faculty in Greece providing a curriculum on molecular biology and genetics. (
  • The Department of Molecular Biology & Genetics (MBG) of Democritus University Thrace set out to take advantage of the specific topics addressed by Activity 4.1 "Unlocking and developing the research potential in the EU's convergence regions and outermost regions" of the FP7-Research Capacities programme-REGPOT-2008-1, towards the convergence with the R&D ranking of EU education and research units of similar size. (
  • Molecular biology has come to dominate our perceptions of life, health and disease. (
  • In the decades following World War II, the Medical Research Council Laboratory of Molecular Biology at Cambridge was a world-renowned centre of this emerging discipline. (
  • Soraya de Chadarevian's important study was the first to examine the creation and expansion of molecular biology through the prism of this remarkable institution. (
  • Firmly placing the history of the laboratory in its broader institutional and scientific context, she shows how molecular biology was built at the lab bench and through the wide circulation of tools, models and researchers, as well as in governmental committees, international exhibitions and television studios. (
  • Designs for Life is a major contribution both to the history of molecular biology, and to the history of science and technology in post-war Britain. (
  • Review of the hardback: 'De Chadarevian's historical account is recommended to all who are interested in the development of molecular biology. (
  • Review of the hardback: 'This is a scholarly work … but it is also very readable … the book is a 'must' for academics teaching molecular biology, and for anyone with even a passing interest in the history of what perhaps will be the most pervasive science of the 21st century. (
  • Review of the hardback: '… the book provides a fresh perspective on well-trodden ground and should fuel the continuing controversy about how, where and why molecular biology first came into being. (
  • Review of the hardback: '… Designs for Life is a very useful addition to the history of molecular biology. (
  • Using a combination of DNA, biochemistry, and molecular biology hardware, researchers seek to use DNA sequencing for data storage and to perform complex calculations. (
  • For almost 40 years, Levitt, professor of structural biology, has been merging the worlds of biology and computers to create dynamic models of proteins, nucleic acids and other macromolecules. (
  • The mission of the Center for Molecular Engineering ( CME ) is to translate advances in materials science, physics, chemistry, biology and computation into new tools to address important societal problems. (
  • First term of work experience in the Molecular Biology and Biochemistry Co-operative Education Program. (
  • An introduction to molecular biology techniques and methods of protein purification and analysis. (
  • Students from all faculties (including science) will work together in a team-based approach to understand the fundamentals of cell biology and molecular biology in the context of science fiction literature. (
  • Of prime importance for this truly interdisciplinary event will be the integration of the three disciplines Computer Science, Biology, and Chemistry. (
  • The invention of PCR was revolutionary to molecular biology . (
  • These probes are used in nucleic acid hybridization, in situ hybridization and other molecular biology procedures. (
  • Background: The Next Generation (NexGen) of Risk Assessment effort is a multiyear collaboration among several organizations evaluating new, potentially more efficient molecular, computational and systems biology approaches to risk assessment. (
  • The biological sciences, or the life sciences, encompass a broad spectrum of subjects from molecular biology to ecology as well as such disciplines as biochemistry, biophysics, genetics and physiology. (
  • I am pleased to announce that Donald Welsh, PhD, professor in the Department of Physiology and Pharmacology and scientist at Robarts Research Institute, has been appointed to the position of the Cecil and Linda Rorabeck Chair in Molecular Neuroscience and Vascular Biology, at the Schulich School of Medicine & Dentistry, Western University. (
  • As the Cecil and Linda Rorabeck Chair in Molecular Neuroscience and Vascular Biology, Professor Welsh will join 450 active researchers at the Schulich Medicine & Dentistry with more than 130 million dollars in annual research funding and join more than 40 researchers within the Robarts Research Institute. (
  • So, bioinformatics combines computer science and biology in order to make heads or tails out of all of this sequence data we're making. (
  • A significant portion of our lawyers have earned advanced degrees in key scientific and technological disciplines, including molecular biology, chemical, mechanical and electrical engineering, computer science, life sciences, and pharmaceutical science. (
  • The method and results have potential applications in cell and molecular biology as well as self-assembly for organic and inorganic systems. (
  • Dr. Scarpati has advanced degrees in the areas of molecular biology, which he leverages to draft and prosecute patent applications related to biotechnology, pharmaceuticals, diagnostics, agricultural products, medical devices, and related life sciences subject matter. (
  • The Graduate Group in Biochemistry, Molecular, Cellular & Developmental Biology offers programs of study and research leading to M.S. and Ph.D. degrees. (
  • Computer-aided drug design comprises computational methods and resources that are used to facilitate the design and discovery of new therapeutic solutions. (
  • Computational modeling revealed molecular interactions involved in ligand binding and further highlighted interactions that have been conserved in evolutionarily divergent amino acid receptors. (
  • The focus of the symposium is computational methods for the modelling, analysis and exploration of all aspects of life sciences, ranging from effects on the molecular level to complex interactions networks. (
  • During the past 14 years Professor Welsh has methodically built an integrative, basic biomedical research laboratory currently comprised of 7 trainees (two postdoctoral fellows, two graduate students, one undergraduate student and two technicians) and a range of experimental equipment (two patch clamp rigs, three isolated vessel set ups, two confocal microscopes, PCR and western blotting equipment, computers for computational modeling). (
  • created this Urban Dynamics and Spatial for complex Contemporary Computer Assisted spoken). (
  • For the best and most different Contemporary Computer Assisted Approaches to Urban Dynamics and Spatial Choice PC 1989 in our composition, exist examine your manufacturing. (
  • The herein formulated therapeutic liquid mixtures, including ethambutol, arginine, citric acid and water under different molar ratios, were studied through a molecular dynamics approach to understand how ethambutol and arginine could be stabilized by the presence of citric acid and/or water in the mixture. (
  • We present a truly scalable First-Principles Molecular Dynamics algorithm with O(N) complexity and fully controllable accuracy, capable of simulating systems of sizes that were previously impossible with this degree of accuracy. (
  • We demonstrate the algorithm's excellent parallel scaling for up to 100,000 atoms on 100,000 processors, with a wall-clock time of the order of one minute per molecular dynamics time step. (
  • Molecular dynamics methodologies such as Hamiltonian Annealing and sampling enhanced free energy calculations are ideal both for the research problems described here and the computer resources available for the allocation. (
  • Currently I am running ACEMD2:GPU molecular dynamics 6.16 (cuda 42) and after approximately 17 hours runtime with a projected 19 hours to run this compares poorly to the Windows 7 64 bit GTX 570 EVGA video card with approximately 6900 seconds average runtime for comparable ACEMD2 work units. (
  • Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020. (
  • We have been able to show that our gate-oxide technology is better than commercially available transistors: What the trillion-dollar semiconductor industry can do today - we can essentially beat them," said study senior author Sayeef Salahuddin, the TSMC Distinguished professor of Electrical Engineering and Computer Sciences at UC Berkeley. (
  • The School of Biological Sciences provides PhD and MPhil (research degree) programmes in subjects ranging from basic biochemistry, molecular genetics and cancer research, to agricultural science, marine ecology and the economic evaluation of ecosystem services and food retailing. (
  • The Center for Molecular Engineering - a partner organization to the Pritzker School of Molecular Engineering at The University of Chicago - pulls together capabilities and resources from across Argonne's multi-disciplinary research divisions and The University of Chicago to deliver breakthrough science and engineering that helps our external partners achieve their goals and makes the world a better place. (
  • Nanowerk News ) Researchers at the University of Chicago's Pritzker School of Molecular Engineering (PME) have discovered a new material, MnBi 6 Te 10 , which can be used to create quantum highways along which electrons can move. (
  • Michael Levitt, PhD, however, prefers a different medium-the 1's and 0's of computer science. (
  • Bioinformatics merges computer and information science with the study of genetic information and biological structures. (
  • The skylit atrium of the multidisciplinary Beckman Institute for Advanced Science and Technology at the University of Illinois at Urbana-Champaign [left] allows scientists and engineers in the biological, chemical, engineering, and computer laboratories and in the faculty offices to view each other. (
  • Time is priceless, and Science, Molecular and Cellular is completely free set. (
  • And shuttling my Science, Molecular and Cellular majority of professors assigning for college homework help. (
  • There are more and more options for commercial software that allow laboratories without people with computer science backgrounds perform these advanced analyses. (
  • University with a joint appointment in the School of Electrical Computer and Energy Engineering and the Department of Speech and Hearing Science. (
  • Abstract: This lecture satisfies requirements for CSCI 591: Computer Science Research Colloquium. (
  • He also has a degree in computer science, providing cross-disciplinary expertise necessary for the prosecution of software patents. (
  • Human Genetics Center and Institute of Molecular Medicine, University of Texas-Houston Health Science Center, Houston, Texas. (
  • Journal of computer science and technology (La Plata. (
  • Knowledge of R and statistics, marine invertebrate identification, laboratory based molecular analyses, experience of running experiments. (
  • Using an IBM Aptiva S-series computer and data from the Protein Database of the US Department of Energy's Brookhaven National Laboratory, she and a colleague examined the structure-function relationships of cellulases, enzymes that break down cellulose. (
  • Molecular diagnostics in South Africa and challenges in the establishment of a molecular laboratory in developing countries. (
  • Some scientists believe DNA computers may one day replace silicon-based hardware. (
  • The school's Center for Applied Research & Technology will use the funds to research into dendrimers, a tiny molecular structure that interacts with cells, letting scientists probe, manipulate, diagnose or cure them on a nanoscale. (
  • Scientists worldwide conduct cancer epidemiology studies, cancer bioassays, and a wide variety of molecular and mechanistic studies to identify specific causes of cancer and to understand the mechanisms by which cancer develops. (
  • In October 2017, the company launched a new family of rugged pre-integrated avionics computers. (
  • methods included molecular epidemiology and clinical studies, bioinformatic knowledge mining, pathway and network analyses, short-duration in vivo and in vitro bioassays, and quantitative structure activity relationship modeling. (
  • In a study published online in the journal Nature on April 6, 2022, University of California, Berkeley, engineers describe a major breakthrough in the design of a component of transistors - the tiny electrical switches that form the building blocks of computers - that could significantly reduce their energy consumption without sacrificing speed, size or performance. (
  • If you could digitally control assembly at the molecular level, and make every single strand bespoke, then you can make amazing materials," he continues. (
  • Should you might digitally management meeting on the molecular degree, and make each single strand bespoke, then you can also make superb supplies," he continues. (
  • QA75 Electronic computers. (
  • FIND) has partnered with Cepheid, Inc. (Sunnyvale, CA) and the University of Medicine and Dentistry of New Jersey (UMDNJ, Newark, NY) to develop a TB-specific automated, cartridge-based nucleic amplification assay (Xpert MTB/RIF) based on the GeneXpert multi-disease platform, currently unique in its simplification of molecular testing with fully integrated and automated sample preparation, amplification and detection required for real-time polymerase chain reaction. (
  • The CDC's Office of Advanced Molecular Detection is doing a great job of helping educate people on what bioinformatics is and how it's being applied. (
  • Michael Levitt is working to create computer simulations of the protein myosin expanding and contracting. (
  • If you have certain atoms sitting in certain locations and if you know something about the forces between the atoms, then you can create computer-based simulations that predict how everything will interact and move," said Levitt. (
  • The project will combine experimental field and lab work with computer simulations to resolve and assess the stability of model marine food webs. (
  • The expression in the extracellular matrix Nerve Growth Factor Receptor (NGFR) Proteins Gene ID marker Col1A1 was significantly increased in the The expression in the extracellular matrix marker Col1A1 was significantly increased inside the hTLCs stimulated with Computer and AlloPL (Figure 4B). (
  • Computer simulation of molecular docking between methylene blue and some proteins of Porphyromonas gingivalis ]. (
  • Further molecular characterization determined that these isolates all contained staphylococcal cassette chromosome (SCC) mec V, were negative for Panton-Valentine leukocidin, and were closely related by macrorestriction analysis with the restriction enzyme Cfr91 . (
  • In other words, they found that you can use the fundamental processes of physics and chemistry to relay information at the molecular level. (
  • In different phrases, they discovered that you should utilize the basic processes of physics and chemistry to relay data on the molecular degree. (
  • Researchers develop the first DNA computer capable of pinpointing several antibodies in the blood and carrying through resultant calculations. (
  • A team of researchers has developed an intelligent DNA computer that can enable controlled drug delivery into the bloodstream. (
  • With DNA nano-computers able to detect and measure antibodies while performing complex analyses, researchers are hopeful machines can be programmed to carry out actions in response to certain measurements. (
  • But in recent decades, some researchers have been putting the letters of the genetic code to a different use: making tiny nanoscale computers. (
  • Researchers have identified a molecular pathway that activates sperm . (
  • Biochemical and molecular aspects of cellular function, interactions and communication including cell cycle, apoptosis, cancer, immune system, neuronal transmission and the signal transduction pathways that integrate them. (
  • Introduction to physical biochemistry including thermodynamics, spectroscopic principles and applications, and molecular transport and interactions. (
  • Computers whose input, output and state transitions are carried out by biochemical interactions and reactions. (
  • Since S -palmitoylation and cholesterol homeostasis are crucial for viral infections, we investigated IFITM interactions with cholesterol by molecular dynamic stimulations, nuclear magnetic resonance analysis in vitro and photoaffinity crosslinking in mammalian cells. (
  • Basak, SC & Restrepo, G 2012, ' Topological and electrotopological descriptors of molecules: Fundamental principles and applications to computer aided molecular design - Part I, A special issue of current computer-aided drug design honoring professor Lemont B. Kier on his eightieth birthday ', Current computer-aided drug design , vol. 8, no. 2, pp. 83-84. (
  • Nanotechnology pioneer Eric Drexler and Rice University Professor and Nobelist Richard Smalley have engaged in a crucial debate on the feasibility of molecular assembly. (
  • Nanotechnology pioneer Eric Drexler and Rice University Professor and Nobelist Richard Smalley have engaged in a crucial debate on the feasibility of molecular assembly, which is the key to the most revolutionary capabilities of nanotechnology. (
  • At the second English computer conference held in Manchester from July 9-12, 1951 computer scientist John Makepiece Bennett and biochemist and crystallographer John Kendrew described their use of the Cambridge EDSAC for the computation of Fourier syntheses in the calculation of structure factors of the protein molecule myoglobin . (
  • In 1962 Kendrew received the Nobel Prize in chemistry for his discovery of the 3-dimensional molecular structure of myoglobin , the first protein molecule to be "solved. (
  • Further, by introducing localized mobility parameters, we are able to simulate molecular gradients that are observed in non-homogeneous protein distributionsin vivo. (
  • They used the Align, Clustal V, and FASTA programs to compare the amino acid sequences and exploited overseas protein sequence databases to study the molecular evolution of a nuclease, an enzyme that splits nucleic acids. (
  • Drexler described a Von Neumann Kinematic Constructor, which for its "sea of parts" used atoms and molecular fragments, as suggested in Feynman's speech. (
  • Von Neumann's Universal Constructor, as applied to atoms and molecular fragments, was now called a "universal assembler. (
  • Modern molecular biological and recombinant nucleic acid methods will be covered. (
  • With the help of computer-assisted, bioinformatic methods, they identify those factors that cause biological systems to become unbalanced - and thus lead to diseases. (
  • Supported by underpinning technological expertise in cutting edge molecular, genomic, transcriptomic/proteomic and metabolomic methods, the goal of the theme is to transform Agri-Food systems so that they benefit both human nutrition and health while simultaneously reducing the greenhouse gases emissions from livestock production systems, protecting ecological resources, supporting livelihoods and affordable foods, and upholding social, cultural, and ethical values. (
  • The results indicate that ATV algorithm works well in general case in improving reliability performance for diffusion‐based molecular communication. (
  • We are now aiming at using computer vision and artificial intelligence algorithm on whole-slide tissue images to identify the most clinically relevant morphological features. (
  • Lectures will be given by both international and local speakers from the research fields of structural bioinformatics and computer-aided drug design. (
  • Fear, you know, I think laboratories hear the term bioinformatics and it conjures up these visions of huge rooms full of computers and all of these guys sitting down in front of, you know, a tech screen writing code from scratch. (
  • STATE COLLEGE, PENNSYLVANIA [February 09, 2021] - QuantumBio Inc. published results on the impact of QuantumBio's X-ray refinement toolkit on binding affinity prediction and how crystallography and computer-aided drug design (CADD) can be used-synergistically-to improve our understanding of structure and function. (
  • ECSA Scientific Week 2021 (22-24 March 2021): Using computer vision and artificial intelligence to improve lung neuroendocrine tumours (LNET) classification. (
  • Traditionally, cancer classification has been based on consensus of histopathological opinion, with very limited consideration of molecular pathology. (
  • The key to the success in the actual synthesis was our molecular design and detailed examination of the reaction conditions," adds Segawa. (
  • Standard slide applications cannot bring molecular intelligence to class room discussions. (
  • To see how their circuit would perform over time as the reactions proceeded, Reif and Duke graduate student Tianqi Song used computer software to simulate the reactions over a range of input concentrations. (
  • A study of the molecular processes which underlie cell structure and function, integrating ultrastructural, physiological and biochemical approaches. (
  • To do this, we investigate the molecular connections that keep biological systems in balance. (
  • The purpose of this paper is evaluate the usefulness of computer modeling in improving ore pass design and Computer modeling of rock flow in ore passes is thereby reduce the threat of structural damage and being investigated and compared using MSC Soft- improve miner safety. (
  • 1991 , " A Group Contribution Approach to Computer Aided Molecular Design ," AIChE Journal , Vol. (
  • With this in mind, the development of the brush biopsy (Oral CDx R) coupled with a computer-assisted method of analysis has brought accurate diagnosis, ease of performance, and patient acceptance into daily practice. (
  • Molecular diagnosis of polymicrobial brain abscesses with 16S rDNA-based next generation sequencing. (
  • Integrating the molecular and morphological data will also shed light on the etiology of these diseases, and inform/improve their diagnosis, classification, and clinical management. (
  • The rapid improvement in computer technology, including artificial intelligence, is already producing clinically applicable aids to diagnosis, and this trend is likely to accelerate. (
  • The characteristics of each cancer type, including diagnostic criteria, pathological features, and associated molecular alterations, are described and illustrated in a strictly disease-oriented manner to provide the international standards for diagnosis and cancer research. (
  • The military computers market size is expected to grow from USD 7.9 billion in 2018 to USD 10.5 billion by 2023, at a CAGR of 5.85% during the forecast period. (
  • Smalley's position, which denies both the promise and the peril of molecular assembly, will ultimately backfire and will fail to guide nanotechnology research in the needed constructive direction, says Ray Kurzweil. (
  • Although Smalley was originally inspired by Drexler's ground-breaking works and has himself become a champion of contemporary research initiatives in nanotechnology, he has also taken on the role of key critic of Drexler's primary idea of precisely guided molecular manufacturing. (
  • Nanotechnology promises the tools to rebuild the physical world, our bodies and brains included, molecular fragment by molecular fragment, potentially atom by atom. (
  • An even earlier conceptual root for nanotechnology was formulated by the information theorist John Von Neumann in the early 1950s with his model of a self-replicating system based on a universal constructor combined with a universal computer. (
  • The article is currently available under Open Access and will be published in a special issue of the Journal of Computer-AidedMolecular Design (JCAMD) . (
  • Under- for Occupational Safety and Health to determine the standing rock trajectories during a dump cycle, the usefulness of computer modeling to improve ore pass degree of ore pass inclination, and the effects of rock design. (
  • The computer program developed under this work was used for the systematic design of possible absorbents. (
  • Current computer-aided drug design , 8 (2), 83-84. (
  • Electrical and Computer Engineering, Michigan State Univ. (
  • At this level of description, Von Neumann's proposal is quite abstract - the computer and constructor could be made in a great variety of ways, as well as from diverse materials, and could even be a theoretical mathematical construction. (
  • It's additionally not but doable to "write" data utilizing a molecular pc, which is what can be required to really fabricate new medication or plastics. (
  • The obtained photon count is transferred to computer for recording and data processing. (
  • You know, with so much data that's being generated, we need to use computers to help us understand what's going on. (
  • Therefore, these wires cannot be used to connect parts of quantum computers that encode data in the quantum properties of electrons. (
  • Quantum computers store data in qubits, a basic unit of information that exhibits quantum properties including superposition. (
  • PCR, coupled with fluorescence techniques and computer technology, allows the real time amplification of DNA. (
  • To help illustrate that they can be flexible in terms of what types of computer technologies they can use and the types of analyses they can do. (
  • The molecular bases of both clinically defined conditions remain unknown in spite of the widespread application of genome analyses in both clinic and research. (
  • The major driving factors for the military computers market are the modernization of weapon systems, demand for portable and rugged computers in battlefields, and shift from traditional warfare toward technological warfare. (