Computer-based representation of physical systems and phenomena such as chemical processes.
The attitude and behavior associated with an individual using the computer.
Various units or machines that operate in combination or in conjunction with a computer but are not physically part of it. Peripheral devices typically display computer data, store data from the computer and return the data to the computer on demand, prepare data for human use, or acquire data from a source and convert it to a form usable by a computer. (Computer Dictionary, 4th ed.)
Familiarity and comfort in using computers efficiently.
Systems composed of a computer or computers, peripheral equipment, such as disks, printers, and terminals, and telecommunications capabilities.
A type of MICROCOMPUTER, sometimes called a personal digital assistant, that is very small and portable and fitting in a hand. They are convenient to use in clinical and other field situations for quick data management. They usually require docking with MICROCOMPUTERS for updates.
Process of teaching a person to interact and communicate with a computer.
Input/output devices designed to receive data in an environment associated with the job to be performed, and capable of transmitting entries to, and obtaining output from, the system of which it is a part. (Computer Dictionary, 4th ed.)
Computers in which quantities are represented by physical variables; problem parameters are translated into equivalent mechanical or electrical circuits as an analog for the physical phenomenon being investigated. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Sequential operating programs and data which instruct the functioning of a digital computer.
Application of computer programs designed to assist the physician in solving a diagnostic problem.
A system containing any combination of computers, computer terminals, printers, audio or visual display devices, or telephones interconnected by telecommunications equipment or cables: used to transmit or receive information. (Random House Unabridged Dictionary, 2d ed)
The process of pictorial communication, between human and computers, in which the computer input and output have the form of charts, drawings, or other appropriate pictorial representation.
A self-learning technique, usually online, involving interaction of the student with programmed instructional materials.
Small computers that lack the speed, memory capacity, and instructional capability of the full-size computer but usually retain its programmable flexibility. They are larger, faster, and more flexible, powerful, and expensive than microcomputers.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Integrated set of files, procedures, and equipment for the storage, manipulation, and retrieval of information.
Computers whose input, output and state transitions are carried out by biochemical interactions and reactions.
Data processing largely performed by automatic means.
The visual display of data in a man-machine system. An example is when data is called from the computer and transmitted to a CATHODE RAY TUBE DISPLAY or LIQUID CRYSTAL display.
Text editing and storage functions using computer software.
Computer-based systems for input, storage, display, retrieval, and printing of information contained in a patient's medical record.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.
Computers that combine the functions of analog and digital computers. (Sippl, Computer Dictionary, 4th ed)
A computer architecture, implementable in either hardware or software, modeled after biological neural networks. Like the biological system in which the processing capability is a result of the interconnection strengths between arrays of nonlinear processing nodes, computerized neural networks, often called perceptrons or multilayer connectionist models, consist of neuron-like units. A homogeneous group of units makes up a layer. These networks are good at pattern recognition. They are adaptive, performing tasks by example, and thus are better for decision-making than are linear learning machines or cluster analysis. They do not require explicit programming.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Computer systems utilized as adjuncts in the treatment of disease.
The science of designing, building or equipping mechanical devices or artificial environments to the anthropometric, physiological, or psychological requirements of the people who will use them.
Harmful and painful condition caused by overuse or overexertion of some part of the musculoskeletal system, often resulting from work-related physical activities. It is characterized by inflammation, pain, or dysfunction of the involved joints, bones, ligaments, and nerves.
Surgical procedures conducted with the aid of computers. This is most frequently used in orthopedic and laparoscopic surgery for implant placement and instrument guidance. Image-guided surgery interactively combines prior CT scans or MRI images with real-time video.
Use of computers or computer systems for doing routine clerical work, e.g., billing, records pertaining to the administration of the office, etc.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Devices capable of receiving data, retaining data for an indefinite or finite period of time, and supplying data upon demand.
Systems where the input data enter the computer directly from the point of origin (usually a terminal or workstation) and/or in which output data are transmitted directly to that terminal point of origin. (Sippl, Computer Dictionary, 4th ed)
Integrated, computer-assisted systems designed to store, manipulate, and retrieve information concerned with the administrative and clinical aspects of providing medical services within the hospital.
The use of computers for designing and/or manufacturing of anything, including drugs, surgical procedures, orthotics, and prosthetics.
Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Materials, frequently computer applications, that combine some or all of text, sound, graphics, animation, and video into integrated packages. (Thesaurus of ERIC Descriptors, 1994)
Elements of limited time intervals, contributing to particular results or situations.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
The transmission and reproduction of transient images of fixed or moving objects. An electronic system of transmitting such images together with sound over a wire or through space by apparatus that converts light and sound into electrical waves and reconverts them into visible light rays and audible sound. (From Webster, 3rd ed)
The deductive study of shape, quantity, and dependence. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Three-dimensional representation to show anatomic structures. Models may be used in place of intact animals or organisms for teaching, practice, and study.
Automated systems applied to the patient care process including diagnosis, therapy, and systems of communicating medical data within the health care setting.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Specifications and instructions applied to the software.
Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of ambulatory care services and facilities.
Diseases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage viewed collectively.
The field of information science concerned with the analysis and dissemination of medical data through the application of computers to various aspects of health care and medicine.
The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Equipment that provides mentally or physically disabled persons with a means of communication. The aids include display boards, typewriters, cathode ray tubes, computers, and speech synthesizers. The output of such aids includes written words, artificial speech, language signs, Morse code, and pictures.
A system in which the functions of the man and the machine are interrelated and necessary for the operation of the system.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Organized activities related to the storage, location, search, and retrieval of information.
Recording of pertinent information concerning patient's illness or illnesses.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
A series of steps taken in order to conduct research.
Methods of creating machines and devices.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Computer-assisted analysis and processing of problems in a particular area.
Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
In statistics, a technique for numerically approximating the solution of a mathematical problem by studying the distribution of some random variable, often generated by a computer. The name alludes to the randomness characteristic of the games of chance played at the gambling casinos in Monte Carlo. (From Random House Unabridged Dictionary, 2d ed, 1993)
Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
The study of the structure of various TISSUES of organisms on a microscopic level.
Controlled operation of an apparatus, process, or system by mechanical or electronic devices that take the place of human organs of observation, effort, and decision. (From Webster's Collegiate Dictionary, 1993)
Unilateral or bilateral pain of the shoulder. It is often caused by physical activities such as work or sports participation, but may also be pathologic in origin.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Computer-based information systems used to integrate clinical and patient information and provide support for decision-making in patient care.
Instrumentation consisting of hardware and software that communicates with the BRAIN. The hardware component of the interface records brain signals, while the software component analyzes the signals and converts them into a command that controls a device or sends a feedback signal to the brain.
The storing or preserving of video signals for television to be played back later via a transmitter or receiver. Recordings may be made on magnetic tape or discs (VIDEODISC RECORDING).
An optical disk storage system for computers on which data can be read or from which data can be retrieved but not entered or modified. A CD-ROM unit is almost identical to the compact disk playback device for home use.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Improvement in the quality of an x-ray image by use of an intensifying screen, tube, or filter and by optimum exposure techniques. Digital processing methods are often employed.
Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of radiology services and facilities.
Precise procedural mathematical and logical operations utilized in the study of medical information pertaining to health care.
Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.
Computer programs based on knowledge developed from consultation with experts on a problem, and the processing and/or formalizing of this knowledge using these programs in such a manner that the problems may be solved.
The biological science concerned with the life-supporting properties, functions, and processes of living organisms or their parts.
Specific languages used to prepare computer programs.
Computer systems or networks designed to provide radiographic interpretive information.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses.
Term generally used to describe complaints related to refractive error, ocular muscle imbalance, including pain or aching around the eyes, burning and itchiness of the eyelids, ocular fatigue, and headaches.
A medical specialty concerned with the provision of continuing, comprehensive primary health care for the entire family.
Systematic identification, development, organization, or utilization of educational resources and the management of these processes. It is occasionally used also in a more limited sense to describe the use of equipment-oriented techniques or audiovisual aids in educational settings. (Thesaurus of ERIC Descriptors, December 1993, p132)
Transmission of information over distances via electronic means.
Systematic organization, storage, retrieval, and dissemination of specialized information, especially of a scientific or technical nature (From ALA Glossary of Library and Information Science, 1983). It often involves authenticating or validating information.
Method of making images on a sensitized surface by exposure to light or other radiant energy.
Facilities equipped to carry out investigative procedures.
Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.
The rate dynamics in chemical or physical systems.
Laboratory and other services provided to patients at the bedside. These include diagnostic and laboratory testing using automated information entry.
Diseases caused by factors involved in one's employment.
Theory and development of COMPUTER SYSTEMS which perform tasks that normally require human intelligence. Such tasks may include speech recognition, LEARNING; VISUAL PERCEPTION; MATHEMATICAL COMPUTING; reasoning, PROBLEM SOLVING, DECISION-MAKING, and translation of language.
Discomfort or more intense forms of pain that are localized to the cervical region. This term generally refers to pain in the posterior or lateral regions of the neck.
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
Auditory and visual instructional materials.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative activities associated with the provision and utilization of clinical pharmacy services.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Organized services to provide information on any questions an individual might have using databases and other sources. (From Random House Unabridged Dictionary, 2d ed)
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Delivery of health services via remote telecommunications. This includes interactive consultative and diagnostic services.
Major administrative divisions of the hospital.
The detailed examination of observable activity or behavior associated with the execution or completion of a required function or unit of work.
Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
In INFORMATION RETRIEVAL, machine-sensing or identification of visible patterns (shapes, forms, and configurations). (Harrod's Librarians' Glossary, 7th ed)
The position or attitude of the body.
Individuals enrolled in a school of medicine or a formal educational program in medicine.
The privacy of information and its protection against unauthorized disclosure.
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
A branch of biology dealing with the structure of organisms.
The electronic transmission of radiological images from one location to another for the purposes of interpretation and/or consultation. Users in different locations may simultaneously view images with greater access to secondary consultations and improved continuing education. (From American College of Radiology, ACR Standard for Teleradiology, 1994, p3)
The organization and operation of the business aspects of a dental practice.
Absolute, comparative, or differential costs pertaining to services, institutions, resources, etc., or the analysis and study of these costs.
The study of chance processes or the relative frequency characterizing a chance process.
A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease.
Organized collections of computer records, standardized in format and content, that are stored in any of a variety of computer-readable modes. They are the basic sets of data from which computer-readable files are created. (from ALA Glossary of Library and Information Science, 1983)
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
The application of scientific knowledge to practical purposes in any field. It includes methods, techniques, and instrumentation.
General or unspecified injuries involving the arm.
Description of pattern of recurrent functions or procedures frequently found in organizational processes, such as notification, decision, and action.
The study, control, and application of the conduction of ELECTRICITY through gases or vacuum, or through semiconducting or conducting materials. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
The period of medical education in a medical school. In the United States it follows the baccalaureate degree and precedes the granting of the M.D.
Customer satisfaction or dissatisfaction with a benefit or service received.
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)
The act of testing the software for compliance with a standard.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
Individuals licensed to practice medicine.
A computer based method of simulating or analyzing the behavior of structures or components.
Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.
Systems used to prompt or aid the memory. The systems can be computerized reminders, color coding, telephone calls, or devices such as letters and postcards.
The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph.
Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)
The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.
Hospital department which administers and provides pathology services.
The research and development of ELECTRICAL EQUIPMENT AND SUPPLIES for such medical applications as diagnosis, therapy, research, anesthesia control, cardiac control, and surgery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Software designed to store, manipulate, manage, and control data for specific uses.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The field of knowledge, theory, and technology dealing with the collection of facts and figures, and the processes and methods involved in their manipulation, storage, dissemination, publication, and retrieval. It includes the fields of COMMUNICATION; PUBLISHING; LIBRARY SCIENCE; and informatics.
Part of the body in humans and primates where the arms connect to the trunk. The shoulder has five joints; ACROMIOCLAVICULAR joint, CORACOCLAVICULAR joint, GLENOHUMERAL joint, scapulathoracic joint, and STERNOCLAVICULAR joint.
A management function in which standards and guidelines are developed for the development, maintenance, and handling of forms and records.
Usual level of physical activity that is less than 30 minutes of moderate-intensity activity on most days of the week.
Processes that incorporate some element of randomness, used particularly to refer to a time series of random variables.
A specialty concerned with the nature and cause of disease as expressed by changes in cellular or tissue structure and function caused by the disease process.
The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.
The educational process of instructing.
The region of the upper limb in animals, extending from the deltoid region to the HAND, and including the ARM; AXILLA; and SHOULDER.
Studies in which the presence or absence of disease or other health-related variables are determined in each member of the study population or in a representative sample at one particular time. This contrasts with LONGITUDINAL STUDIES which are followed over a period of time.
The study of PHYSICAL PHENOMENA and PHYSICAL PROCESSES as applied to living things.
Data recorded by nurses concerning the nursing care given to the patient, including judgment of the patient's progress.
Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.
Method of analyzing chemicals using automation.
The procedures involved in combining separately developed modules, components, or subsystems so that they work together as a complete system. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Information systems, usually computer-assisted, designed to store, manipulate, and retrieve information for planning, organizing, directing, and controlling administrative and clinical activities associated with the provision and utilization of clinical laboratory services.
The commitment in writing, as authentic evidence, of something having legal importance. The concept includes certificates of birth, death, etc., as well as hospital, medical, and other institutional records.
Communications networks connecting various hardware devices together within or between buildings by means of a continuous cable or voice data telephone system.
Method for assessing flow through a system by injection of a known quantity of dye into the system and monitoring its concentration over time at a specific point in the system. (From Dorland, 28th ed)
Computer-assisted interpretation and analysis of various mathematical functions related to a particular problem.
The field which deals with illustrative clarification of biomedical concepts, as in the use of diagrams and drawings. The illustration may be produced by hand, photography, computer, or other electronic or mechanical methods.
The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.
The total amount of work to be performed by an individual, a department, or other group of workers in a period of time.
A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.
The promotion and maintenance of physical and mental health in the work environment.
Motion of an object in which either one or more points on a line are fixed. It is also the motion of a particle about a fixed point. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The study of the structure, growth, function, genetics, and reproduction of bacteria, and BACTERIAL INFECTIONS.
The teaching or training of patients concerning their own health needs.

Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies. (1/95)

Increasing resistance of malaria parasites to conventional antimalarial drugs is an important factor contributing to the persistence of the disease as a major health threat. The ongoing search for novel targets has resulted in identification and expression of several enzymes including cysteine proteases that are implicated in hemoglobin degradation. Falcipain-2 and falcipain-3 are considered to be the two principal cysteine proteases in this degradation, and hence, are potential drug targets. A homology model of falcipain-3 was built and validated by various structure/geometry verification tools as well as docking studies of known substrates. The correlation coefficient of 0.975 between interaction energies and K(m) values of these substrates provided additional support for the model. On comparison with the previously reported falcipain-2 homology model, the currently constructed falcipain-3 structure showed important differences between the S2 pockets that might explain the variations in the K(m) values of various substrates for these enzymes. Further, docking studies also provided insight into possible binding modes and interactions of ligands with falcipain-3. Results of the current study could be employed in de novo drug design leading to development of new antimalarial agents.  (+info)

MicroSAGE is highly representative and reproducible but reveals major differences in gene expression among samples obtained from similar tissues. (2/95)

BACKGROUND: Serial analysis of gene expression using small amounts of starting material (microSAGE) has not yet been conclusively shown to be representative, reproducible or accurate. RESULTS: We show that microSAGE is highly representative, reproducible and accurate, but that pronounced differences in gene expression are seen between tissue samples taken from different individuals. CONCLUSIONS: MicroSAGE is a reliable method of comprehensively profiling differences in gene expression among samples, but care should be taken in generalizing results obtained from libraries constructed from tissue obtained from different individuals and/or processed or stored differently.  (+info)

Mining for single nucleotide polymorphisms and insertions/deletions in maize expressed sequence tag data. (3/95)

We have developed a computer based method to identify candidate single nucleotide polymorphisms (SNPs) and small insertions/deletions from expressed sequence tag data. Using a redundancy-based approach, valid SNPs are distinguished from erroneous sequence by their representation multiple times in an alignment of sequence reads. A second measure of validity was also calculated based on the cosegregation of the SNP pattern between multiple SNP loci in an alignment. The utility of this method was demonstrated by applying it to 102,551 maize (Zea mays) expressed sequence tag sequences. A total of 14,832 candidate polymorphisms were identified with an SNP redundancy score of two or greater. Segregation of these SNPs with haplotype indicates that candidate SNPs with high redundancy and cosegregation confidence scores are likely to represent true SNPs. This was confirmed by validation of 264 candidate SNPs from 27 loci, with a range of redundancy and cosegregation scores, in four inbred maize lines. The SNP transition/transversion ratio and insertion/deletion size frequencies correspond to those observed by direct sequencing methods of SNP discovery and suggest that the majority of predicted SNPs and insertion/deletions identified using this approach represent true genetic variation in maize.  (+info)

Directed nucleation assembly of DNA tile complexes for barcode-patterned lattices. (4/95)

The programmed self-assembly of patterned aperiodic molecular structures is a major challenge in nanotechnology and has numerous potential applications for nanofabrication of complex structures and useful devices. Here we report the construction of an aperiodic patterned DNA lattice (barcode lattice) by a self-assembly process of directed nucleation of DNA tiles around a scaffold DNA strand. The input DNA scaffold strand, constructed by ligation of shorter synthetic oligonucleotides, provides layers of the DNA lattice with barcode patterning information represented by the presence or absence of DNA hairpin loops protruding out of the lattice plane. Self-assembly of multiple DNA tiles around the scaffold strand was shown to result in a patterned lattice containing barcode information of 01101. We have also demonstrated the reprogramming of the system to another patterning. An inverted barcode pattern of 10010 was achieved by modifying the scaffold strands and one of the strands composing each tile. A ribbon lattice, consisting of repetitions of the barcode pattern with expected periodicity, was also constructed by the addition of sticky ends. The patterning of both classes of lattices was clearly observable via atomic force microscopy. These results represent a step toward implementation of a visual readout system capable of converting information encoded on a 1D DNA strand into a 2D form readable by advanced microscopic techniques. A functioning visual output method would not only increase the readout speed of DNA-based computers, but may also find use in other sequence identification techniques such as mutation or allele mapping.  (+info)

An autonomous molecular computer for logical control of gene expression. (5/95)

Early biomolecular computer research focused on laboratory-scale, human-operated computers for complex computational problems. Recently, simple molecular-scale autonomous programmable computers were demonstrated allowing both input and output information to be in molecular form. Such computers, using biological molecules as input data and biologically active molecules as outputs, could produce a system for 'logical' control of biological processes. Here we describe an autonomous biomolecular computer that, at least in vitro, logically analyses the levels of messenger RNA species, and in response produces a molecule capable of affecting levels of gene expression. The computer operates at a concentration of close to a trillion computers per microlitre and consists of three programmable modules: a computation module, that is, a stochastic molecular automaton; an input module, by which specific mRNA levels or point mutations regulate software molecule concentrations, and hence automaton transition probabilities; and an output module, capable of controlled release of a short single-stranded DNA molecule. This approach might be applied in vivo to biochemical sensing, genetic engineering and even medical diagnosis and treatment. As a proof of principle we programmed the computer to identify and analyse mRNA of disease-related genes associated with models of small-cell lung cancer and prostate cancer, and to produce a single-stranded DNA molecule modelled after an anticancer drug.  (+info)

Demonstration of a universal surface DNA computer. (6/95)

A fundamental concept in computer science is that of the universal Turing machine, which is an abstract definition of a general purpose computer. A general purpose (universal) computer is defined as one which can compute anything that is computable. It has been shown that any computer which is able to simulate Boolean logic circuits of any complexity is such a general purpose computer. The field of DNA computing was founded in 1994 by Adleman's solution of a 7-bit instance of the Hamiltonian path problem. This work, as well as most of the subsequent experimental and theoretical investigations in the area, focused primarily upon the solution of NP-complete problems, which are a subset of the larger universal class of problems. In the present work a surface DNA computer capable of simulating Boolean logic circuits is demonstrated. This was done by constructing NOR and OR gates and combining them into a simple logic circuit. The NOR gate is one of the universal gates in Boolean logic, meaning that any other logic gate can be built from it alone. The circuit was solved using DNA-based operations, demonstrating the universal nature of this surface DNA computing model.  (+info)

Stochastic computing with biomolecular automata. (7/95)

Stochastic computing has a broad range of applications, yet electronic computers realize its basic step, stochastic choice between alternative computation paths, in a cumbersome way. Biomolecular computers use a different computational paradigm and hence afford novel designs. We constructed a stochastic molecular automaton in which stochastic choice is realized by means of competition between alternative biochemical pathways, and choice probabilities are programmed by the relative molar concentrations of the software molecules coding for the alternatives. Programmable and autonomous stochastic molecular automata have been shown to perform direct analysis of disease-related molecular indicators in vitro and may have the potential to provide in situ medical diagnosis and cure.  (+info)

Rational design of DNA sequences for nanotechnology, microarrays and molecular computers using Eulerian graphs. (8/95)

Nucleic acids are molecules of choice for both established and emerging nanoscale technologies. These technologies benefit from large functional densities of 'DNA processing elements' that can be readily manufactured. To achieve the desired functionality, polynucleotide sequences are currently designed by a process that involves tedious and laborious filtering of potential candidates against a series of requirements and parameters. Here, we present a complete novel methodology for the rapid rational design of large sets of DNA sequences. This method allows for the direct implementation of very complex and detailed requirements for the generated sequences, thus avoiding 'brute force' filtering. At the same time, these sequences have narrow distributions of melting temperatures. The molecular part of the design process can be done without computer assistance, using an efficient 'human engineering' approach by drawing a single blueprint graph that represents all generated sequences. Moreover, the method eliminates the necessity for extensive thermodynamic calculations. Melting temperature can be calculated only once (or not at all). In addition, the isostability of the sequences is independent of the selection of a particular set of thermodynamic parameters. Applications are presented for DNA sequence designs for microarrays, universal microarray zip sequences and electron transfer experiments.  (+info)

An autonomous molecular computer that, when coupled to a molecular model of a disease, is capable of disease diagnosis. The computer preferably performs such diagnosis by detecting one or more disease markers. For example, optionally and preferably the molecular computer checks for the presence of over-expressed, under-expressed and mutated genes, applies programmed medical knowledge to this information to reach a diagnostic decision.
This paper presents a programming language and compiler for designing and simulating DNA circuits in which strand displacement is the main computational mechanism. Starting from an initial set of molecules, the compiler computes the set of all possible reactions together with the set of all possible molecules that can be produced. The generated reactions can then be simulated using standard approaches in order to evaluate the circuit design. This greatly simplifies the design and testing of DNA circuits prior to their subsequent implementation. The language was developed to take into account recent experimental and theoretical results on the design of large-scale, efficient, modular DNA circuits. There are a number of areas for future work, as outlined below.. The strand displacement language differs from traditional imperative languages such as Pascal or C in that the main primitives of the language are geared towards an implementation in physical DNA molecules. In particular, the language ...
Density Functional Theory (DFT) B3PW91-TD\6-311G** model calculations of azo-dye disperse Orange 3 (DO3) molecule charge transfer indicate that in radiationless transitions charge move out from -N=N- bridge that support per linear isomerisation way [1, 2]. The results of light induced internal molecular motions in azo-dyes molecules have been used for the design and B3PW91-Time Dependent (TD)/6-311G** calculations of light driven OR logically controlled molecular machines composed from photoactive organic molecules such as electron donor: dithieno[3,2-b:2,3-d]thiophene and ferocene (C10H10Fe) and electron accepting and moving part of DO3 molecule. Applied DFT-TD method and our visualization program showed from which fragments electron is hopping in various excited states [2]. Further development of molecular machines are performing using B3PW91\6-311G** geometry optimization of larger molecular robots possessing efficient fluorescence (Fluorescein-DO3) and anti-oxidant biological activity ...
There are many computers in California, but only one of them is running inside a living yeast cell.. Future models of the living computer, made from the DNA-like molecule RNA, could be used to run calculations in vivo - that is, inside human cells - to release drugs or prime the immune system at the first hint of illness.. DNA shares its essential features with computers - it stores, processes and communicates information. And in the late 1990s, researchers successfully created a set of DNA molecules - a DNA computer - able to solve simple mathematical problems.. DNA computers since have since proved unbeatable at tic-tac-toe (noughts and crosses), but they are not really suited to high-speed number crunching like a conventional computer.. The real strength of these molecular devices is in working and computing inside biological systems, where DNA has evolved to be at home. ...
The human race has figured out how to make the process of creating products a lot more efficient. Assembly line factories litter the planets landscape, mass producing items piece by piece, maximizing worker efficiency whether it be human or robot workers. In order to maximize the efficiency of making new drugs or plastics, scientists have created a tiny machine that acts as something of an assembly line on the molecular level.. ...
Most proteins function by interacting with other molecules. Their interaction interfaces are highly conserved throughout evolution to avoid undesirable interactions that lead to fatal disorders in cells. Rational drug discovery includes computational methods to identify the interaction sites of lead compounds to the target molecules. Identifying and classifying protein interaction interfaces on a large scale can help researchers discover drug targets more efficiently. We introduce a large-scale protein domain interaction interface database called InterPare http://interpare.net . It contains both inter-chain (between chains) interfaces and intra-chain (within chain) interfaces. InterPare uses three methods to detect interfaces: 1) the geometric distance method for checking the distance between atoms that belong to different domains, 2) Accessible Surface Area (ASA), a method for detecting the buried region of a protein that is detached from a
The new invention is an interesting proof of principle, says Martyn Amos, a bioinformatics researcher at the University of Liverpool, UK. Amos questions whether molecular automata could ever do anything complex enough to be useful, but thinks they may find applications inside cells. DNA computing needs to establish its own niche, and I don t think that lies in competing with traditional silicon devices, says Amos. Biological computers would be better suited to biological problems, such as sensors within organisms or drug delivery, he believes. In 10 years this sort of computational device may be yielding applications that people pay money for, Amos says. Already Shapiro has patented a design for a molecular computer that can perform any calculation. If you look at the mechanisms of a cell, you could easily create a universal computer, he says. We don t need to teach the cell new tricks, we just need to put the existing tricks together in the right order. Cut and paste The new molecular ...
As the graph above shows, Intels/Microns NAND dies have historically been larger than the competitors, so the die capacity alone isnt enough to dictate whether Intels 3D NAND is more cost efficient than Samsung, especially because both have 32 layers. Unlike Samsung, Intel didnt reveal the lithography that is used to manufacture the 3D NAND, but I would say its safe to assume that the lithography is in the order of 30nm or 40nm because the whole idea of 3D NAND is to move away from multi-patterning to cut costs and with todays technology the smallest pitch of single-patterning is somewhere between 30nm and 40nm. Either way, it will be very interesting to see how Intels 3D NAND stacks up against Samsungs because there are also some structural differences that affect the production cost as well as performance and endurance, but Ill save the structural analysis for a future article.. Intel said that 3D NAND technology will enable +10TB SSDs in the next couple of years, but it wasnt ...
This course introduces computational models and computers which have appeared at the intersection of hardware and artificial intelligence in the recent years as an attempt to solve traditionally hard computational problems. The course surveys relevant theoretical models, reconfigurable architectures and computational intelligence techniques inspired at the levels of phylogeny, ontogeny and epigenesis. In particular, the following topics will be discussed: evolutionary design, evolvable hardware, cellular systems, embryonal and neural hardware, molecular computers and nanotechnology. Typical applications will illustrate the mentioned approaches ...
A molecular switch is a molecule or set of molecules that will undergo a pre-defined shift between two or more distinct states in response to a specific stimuli. A schematic illustrating the basic concept is below. There is interest in the development of molecular switches for a variety of applications such as in nanotechnology for application in molecular computers (the different states can represent the binary numerical system 0 and 1).. For this project, we will develop synthetic host compounds that contain a mechanism for a switching stimuli that arises from the stereochemistry (3D shape) of a guest which binds to the host. Depending on the absolute stereochemistry of the guest, the host will exist in one of two different conformations; if the host can exist in conformer A and conformer B, when one enantiomer of a guest binds to the porphyrin host, the host will adopt conformer A. When the opposite enantiomer of a guest binds to the host, the host will adopt conformer B. We aim to utilize ...
ORGANIC BIOPROCESSORS LINKED TO VIRUSES-- One direction that the New World Order took was to develop biochips and bioprocessors, that is three-dimensional organic circuitry that functions as computers. The conductive velocities of these miniature organic computers (protein lattices) are at least one million times faster than nerve cells. The circuit power of a given size of miniature organic computers is at least a million times greater than the same size of brain matter. Molecular computers made of living matter can be grown from DNA templates of genetically engineered bacteria. Synthetic proteins have been developed which match what they want to make into mini-computers. The end product is a bioprocessor (tiny computer) within a cell. These mini-computers are specifically linked with viruses which migrate to specific parts of the body. Viruses are primarily nucleoproteins, some of the small ones are not even alive, and they dont even have metabolism. They do not have a metabolism to kill with ...
ORGANIC BIOPROCESSORS LINKED TO VIRUSES-- One direction that the New World Order took was to develop biochips and bioprocessors, that is three-dimensional organic circuitry that functions as computers. The conductive velocities of these miniature organic computers (protein lattices) are at least one million times faster than nerve cells. The circuit power of a given size of miniature organic computers is at least a million times greater than the same size of brain matter. Molecular computers made of living matter can be grown from DNA templates of genetically engineered bacteria. Synthetic proteins have been developed which match what they want to make into mini-computers. The end product is a bioprocessor (tiny computer) within a cell. These mini-computers are specifically linked with viruses which migrate to specific parts of the body. Viruses are primarily nucleoproteins, some of the small ones are not even alive, and they dont even have metabolism. They do not have a metabolism to kill with ...
We found a paper in which Ben-Yehuda et. al. demostrated that Bacillus subtilis form nanotubes between them, Escherichia coli and Staphylococcus aureus. And they were able to get through a GFP and some other smaller molecules. So, we decided to use this connection to form the principles of a molecular computer. How? The output of the first operation will the input for the next one, and that was what we did. Also, there is not many work in the B. subtilis at the iGEM competition, so we decided to standardize the protocols of competent cells and transformation, and to send biobricks that B. subtilis could transform and integrate for them to work correctly (new standard protocol) ...
We found a paper in which Ben-Yehuda et. al. demostrated that Bacillus subtilis form nanotubes between them, Escherichia coli and Staphylococcus aureus. And they were able to get through a GFP and some other smaller molecules. So, we decided to use this connection to form the principles of a molecular computer. How? The output of the first operation will the input for the next one, and that was what we did. Also, there is not many work in the B. subtilis at the iGEM competition, so we decided to standardize the protocols of competent cells and transformation, and to send biobricks that B. subtilis could transform and integrate for them to work correctly (link al new standar protocol ...
Virtual drug screening is one of the most widely used approaches for finding new drugs candidates. The process consists in selecting one or more chemical compounds with the highest binding free energy to target proteins. Given that the empirical space of chemical compounds is extremely large and estimated to has over 50 millions of them, finding the most effective drug becomes computationally challenging. Furthermore, the vast majority of proteins still lack the experimentally obtained 3D structures required for most of the molecular computer tools available, making it impossible to calculate their binding free energies with chemical compounds. In view of this, the aim of our study is to asses the effectiveness of the Autodock Vina tool in a large environments with unstructured proteins, those without defined 3D structure. The ultimate goal is to enable a fast and efficient virtual drug screening in such an environments, and to apply it for discovery of a new drug candidates.. ...
To convert the circuit with NOT-AND-OR circuit, you need to change the AND gate, NOT gate and OR gate to NAND equivalent. asked May 30 16 at 9:34. I think the pc version has a new function which converts the new nkit format games to another more working format made by a dolphin dev but I dont have a PC to confirm this, can this be ported to the Android version because it will be very useful, the knit format has some bugs in a few games. Just load your binary number and it will automatically get converted to an image. This online calculator provides conversion of kilometers to miles (km to mi) and backwards miles to kilometers.A kilometer is = 0.621371192 miles.It is defined to be equal to 1,760 international yards (one yard = 0.9144 m ) and is therefore equal to 1,609.344 meters (exactly 1.609344 km).The international mile is defined by international agreement. Convert the Logic Diagram using NAND logic gate. How to convert (abc) to a NAND gate? 2,628 3 3 gold badges 18 18 silver badges 24 24 ...
A new cancer-detecting tool uses tiny circuits made of DNA to identify cancer cells by the molecular signatures on their surface. Duke University researchers fashioned the simple circuits fr... Read more ...
The term simulation is construed as a process where the object of investigation is the behavior of a discrete automaton and the means of investigation is a general-purpose computer. The simulation of discrete automata on general-purpose computers is regarded as an autonomous research orientation intended to accelerate the design of digital devices. The method for simulating discrete automata is characterized by three components: an input language, i.e., a means of describing the structure and behavior of discrete automata; a collection of programs assuring the reproduction of the behavior of discrete automata on all-purpose computers (the simulating system); the methodology of research into discrete automata, i.e., techniques of specifying their input sequences and analyzing their output sequences.(*DIGITAL COMPUTERS
In this paper we propose a method and discuss its computational implementation as an integrated tool for the analysis of viral genetic diversity on data generated by high-throughput sequencing. The main motivation for this work is to better understand the genetic diversity of viruses with high rates of nucleotide substitution, as HIV-1 and Influenza. Most methods for viral diversity estimation proposed so far are intended to take benefit of the longer reads produced by some next-generation sequencing platforms in order to estimate a population of haplotypes which represent the diversity of the original population. The method proposed here is custom-made to take advantage of the very low error rate and extremely deep coverage per site, which are the main features of some neglected technologies that have not received much attention due to the short length of its reads, which precludes haplotype estimation. This approach allowed us to avoid some hard problems related to haplotype reconstruction (need of
In this paper we propose a method and discuss its computational implementation as an integrated tool for the analysis of viral genetic diversity on data generated by high-throughput sequencing. The main motivation for this work is to better understand the genetic diversity of viruses with high rates of nucleotide substitution, as HIV-1 and Influenza. Most methods for viral diversity estimation proposed so far are intended to take benefit of the longer reads produced by some next-generation sequencing platforms in order to estimate a population of haplotypes which represent the diversity of the original population. The method proposed here is custom-made to take advantage of the very low error rate and extremely deep coverage per site, which are the main features of some neglected technologies that have not received much attention due to the short length of its reads, which precludes haplotype estimation. This approach allowed us to avoid some hard problems related to haplotype reconstruction (need of
TY - JOUR. T1 - Publisher Correction. T2 - Deep coverage whole genome sequences and plasma lipoprotein(a) in individuals of European and African ancestries (Nature Communications, (2018), 9, 1, (2606), 10.1038/s41467-018-04668-w). AU - NHLBI TOPMed Lipids Working Group. AU - Zekavat, Seyedeh M.. AU - Ruotsalainen, Sanni. AU - Handsaker, Robert E.. AU - Alver, Maris. AU - Bloom, Jonathan. AU - Poterba, Timothy. AU - Seed, Cotton. AU - Ernst, Jason. AU - Chaffin, Mark. AU - Engreitz, Jesse. AU - Peloso, Gina M.. AU - Manichaikul, Ani. AU - Yang, Chaojie. AU - Ryan, Kathleen A.. AU - Fu, Mao. AU - Johnson, W. Craig. AU - Tsai, Michael. AU - Budoff, Matthew. AU - Vasan, Ramachandran S.. AU - Cupples, L. Adrienne. AU - Rotter, Jerome I.. AU - Rich, Stephen S.. AU - Post, Wendy. AU - Mitchell, Braxton D.. AU - Correa, Adolfo. AU - Metspalu, Andres. AU - Wilson, James G.. AU - Salomaa, Veikko. AU - Kellis, Manolis. AU - Daly, Mark J.. AU - Neale, Benjamin M.. AU - McCarroll, Steven. AU - Surakka, ...
Specially for MedChemExpress I-BRD9 low-frequency variants, with deep coverage.Author ContributionsConceived and designed the experiments: OZ MD CB NB.
Today IMFT is announcing that it has begun sampling 2-bits-per-cell MLC NAND flash manufactured using 25nm transistors. The company believed it had a 6 month head start over the competition in 34nm, and now believes that with 25nm NAND its roughly a year ahead of anyone else.. Volume production will happen sometime in Q2, with products shipping before the end of the year. In my last SSD article I mentioned that Intels 3rd generation X25-M would be shipping in Q4 at 160GB, 320GB and 600GB. These drives will use IMFTs new 25nm flash.. The first 25nm product is an 8GB (64Gbit) 2-bits-per-cell MLC NAND flash. A single 8GB die built on IMFTs 25nm process has a die size of 167mm2. Immersion lithography is apparently necessary to produce these 25nm NAND devices, but the extent is unclear. This is technically Intels first device that requires immersion lithography to manufacture. ...
We Have download automata logics, with the Trinity, that adopts the significance of our violence with each conservative. I want, this is an occasional governance to engineer, you want in trick with God, has little it? I know to be this download for actually a panache. We need approved that funding comes a either electronic TB. That it makes to that ample download automata logics, and infinite games: a guide to current in the sweat of God in the day of Christ in the barrage of the hoping contact. It argues all a ve invention. Our download automata logics, with each sleepless diseases from our life with the data. You can point this download automata logics, and infinite games: a guide to current from the sin below and clarify it yourself to stamp how it says and can you talk breath from it better now global members. You would Therefore kill this author once you do this. This eclipse goes occasional loveThat of free meeting books and choices. It can edit neglected the best surveillance ...
Biocomputing uses molecular biology parts as the hardware to implement computational devices. By following pre-defined rules, often hard-coded into biological systems, these devices are able to process inputs and return outputs-thus computing information. Key to the success of any biocomputing endeavor is the availability of a wealth of molecular tools and biological motifs from which functional devices can be assembled. Synthetic biology is a fabulous playground for such purpose, offering numerous genetic parts that allow for the rational engineering of genetic circuits that mimic the behavior of electronic functions, such as logic gates. A grand challenge, as far as biocomputing is concerned, is to expand the molecular hardware available beyond the realm of genetic parts by tapping into the host metabolism. This objective requires the formalization of the interplay of genetic constructs with the rest of the cellular machinery. Furthermore, the field of metabolic engineering has had little intersection
Sustainable urban planning and management require reliable land change models, which can be used to improve decision making. The objective of this study was to test a random forest-cellular automata (RF-CA) model, which combines random forest (RF) and cellular automata (CA) models. The Kappa simulation (KSimulation), figure of merit, and components of agreement and disagreement statistics were used to validate the RF-CA model. Furthermore, the RF-CA model was compared with support vector machine cellular automata (SVM-CA) and logistic regression cellular automata (LR-CA) models. Results show that the RF-CA model outperformed the SVM-CA and LR-CA models. The RF-CA model had a Kappa simulation (KSimulation) accuracy of 0.51 (with a figure of merit statistic of 47%), while SVM-CA and LR-CA models had a KSimulation accuracy of 0.39 and −0.22 (with figure of merit statistics of 39% and 6%), respectively. Generally, the RF-CA model was relatively accurate at allocating
Today we will be looking at the worlds first consumer SSD to feature QLC (Quad Level Cell) NAND Flash. QLC NAND Flash once seemed so far away, but Intel is rolling out the SSD 660p drive series today. The Intel SSD 660p features an SMI controller with Intel firmware optimizations and 3D 64-layer QLC NAND Flash memory ...
Determinization of Büchi automata is a long-known difficult problem, and after the seminal result of Safra, who developed the first asymptotically optimal construction from Büchi into Rabin automata, much work went into improving, simplifying, or avoiding Safras construction. A different, less known determinization construction was proposed by Muller and Schupp. The two types of constructions share some similarities but their precise relationship was still unclear. In this paper, we shed some light on this relationship by proposing a construction from nondeterministic Büchi to deterministic parity automata that subsumes both constructions: Our construction leaves some freedom in the choice of the successor states of the deterministic automaton, and by instantiating these choices in different ways, one obtains as particular cases the construction of Safra and the construction of Muller and Schupp. The basis is a correspondence between structures that are encoded in the macrostates of the ...
After having designed our mechanism at the domain level, we needed to fill in our domains with actual sequences. To start, we picked specific lengths for each of our domains. We decided to stick with the general precedent that toeholds be 6 nucleotides in length, then decided that any domain that was part of a probe be 20 nucleotides in length, as this length is both not wastefully long and long enough to ensure that no spontaneous dissociation would occur. We then decided that any domain longer than a toehold, but not part of the probe system should be 15 base pairs in length, as this would not spontaneously dissociate, but could be easily strand displaced. After these numbers were decided, we consulted a list of 20 nucleotide sequences that are known to be relatively inert and chose sequences from this list to fill in our 20 and 15 nucleotide domains. We used NUPACK and a little trial and error to find our 7 necessary relatively inert toeholds. We then ran a number of simulations in NUPACK to ...
We argue in favor of representing living cells as automata and demonstrate that cells behaving as automata can form patterns by responding to local variations in the strain fields that arise due to their individual or collective motions. A cells response to strain stimuli is assumed to be effected by internally generated, internally powered forces. The forces are a response to the stimulus of external strain conditions, but generally move the cell in directions other than those implied by external energy gradients, including any stresses associated with the stimulating strain fields. Estimates of the time rates of change of elastic strain energy and cell-cell adhesion energy in moving cell populations support the automata depiction: the strain and adhesion energies are orders of magnitude lower than the rate at which metabolic energy is generated by migrating cells. Thus migrating cells have abundant power available to choose to move regardless of, or even in opposition to, external energy gradients.
With a certification from the WD Functional Integrity Testing Lab (F.I.T. Lab™), every WD Blue 3D NAND SATA SSD is verified for compatibility with a wide range of desktop and laptop computers. Every WD Blue 3D NAND SATA SSD goes through extensive compatibility and reliability testing to ensure it meets the high standards of the WD Brand.. Downloadable WD SSD Dashboard and Acronis software ...
The Open NAND Flash Interface (ONFI) Working Group, the organization dedicated to simplifying integration of NAND flash memory into consumer electronic devices, computing platforms, and industrial systems, has published the new ONFI 3.0 standard.
An electrically erasable programmable read-only memory with a NAND cell structure has parallel bit lines, and memory cells defining NAND cell blocks, each of which has a series-circuit of memory cell
NAND flash device controller supplier Silicon Motion Technology is expecting a shortage for the NAND flash industry in the second half of 2016.
Dr. Manohar Nand Kishore is a General Surgeon in Saidapet, Chennai. Book Appointment, Consult Online, View Doctor Fees, Contact Number, User Reviews and Ratings for Dr. Manohar Nand Kishore | Lybrate
Return-Path: ,[email protected], X-Original-To: [email protected] Delivered-To: [email protected] Received: from theia.denx.de (theia.denx.de [85.214.87.163]) by ozlabs.org (Postfix) with ESMTP id F160A2C0087 for ,[email protected],; Tue, 25 Jun 2013 02:51:03 +1000 (EST) Received: from localhost (localhost [127.0.0.1]) by theia.denx.de (Postfix) with ESMTP id E364E4A050; Mon, 24 Jun 2013 18:50:59 +0200 (CEST) X-Virus-Scanned: Debian amavisd-new at theia.denx.de Received: from theia.denx.de ([127.0.0.1]) by localhost (theia.denx.de [127.0.0.1]) (amavisd-new, port 10024) with ESMTP id JzmjONo+Ia0B; Mon, 24 Jun 2013 18:50:59 +0200 (CEST) Received: from theia.denx.de (localhost [127.0.0.1]) by theia.denx.de (Postfix) with ESMTP id E628C4A046; Mon, 24 Jun 2013 18:50:56 +0200 (CEST) Received: from localhost (localhost [127.0.0.1]) by theia.denx.de (Postfix) with ESMTP id 3D54D4A046 for ,[email protected],; Mon, 24 Jun 2013 18:50:52 +0200 (CEST) ...
DNA Circuit System and Charge Transfer Mechanism written by Kunming Xu ,. published by Engineering, Vol.5 No.10, 2013. has been cited by the following article(s):. ...
We used Gibson assembly to build 3 DNA circuits that contain: (1) Wild-type (Contol) PETase, (2) Modified PETase, (3) Modified PETase and MHETase, which are then transformed into our E. coli cells. We utilized AmilCP reporter gene in our DNA to stain cells that are successfully transformed, blue.. To test the enzyme performance of the successfully transformed E. coli, we inoculated these microbes with media in the presence of small plastic PET bottle shreds.. To observe the efficiency of the these enzyme performance, we weighed the small plastic particles before and after inoculation with the E. coli that are expected to express PETase that would degrade the PET plastic particles. We also planned to utilize the Scanning electron microscopy for a more accurate observation of the plastic particles surfaces that might have been degraded or grazed by our PETase enzymes.. The plastic particles exposed to the (1) Wild-type PETase and those exposed to the (2) Modified PETase are analyzed in terms of ...
This book provides essential insights into designing a localized DNA circuit to promote the rate of desired hybridization reactions over undesired leak reactions in the bulk solution.
Previous theoretical or general approaches (Rosen, 1960; Shcherbik and Buchatsky, 2007) to the problems of Quantum Genetics and Molecular Evolution are considered in this article from the point of view of Quantum Automata Theory first published by the author in 1971 (Baianu,1971a, b) , and further developed in several recent articles (Baianu, 1977, 1983, 1987, 2004, 2011).The representation of genomes and Interactome networks in categories of many-valued logic LMn -algebras that are naturally transformed during biological evolution, or evolve through interactions with the environment provide a new insight into the mechanisms of molecular evolution, as well as organismal evolution, in terms of sequences of quantum automata. Phenotypic changes are expressed only when certain environmentally-induced quantum-molecular changes are coupled with an internal re-structuring of major submodules of the genome and Interactome networks related to cell cycling and cell growth. Contrary to the commonly held ...
Linear Bounded Automata The last machine model of computation which we shall examine is the linear bounded automaton or lba PDF document - DocSlides- These were originally developed as models for actual computers rather than models for the computational process They have become important in the theory of computation even though they have not emerged in applications to the extent which pushdown au ID: 22329 ID: 22329
FileZ is a good program, and its what I used to copy every last bit of Palmy goodness from the Palm to the SD card in the first place. Copying back was a little more difficult because FileZ would copy away happily until it ran into a file that already existed. At that point, it would stop mid-batch. Id rather it gave me the option of clobbering the file or even if it skipped that file and did all the others. Either way would have been fine. As it was, I had to delete most of the files off the Palm before doing the copy, taking care not to copy any file that I did not delete. Also, some files would just recreate themselves after deletion ...
The iTunes Music Store has been successful. As I say, this is not the same kind of success as a market with competition, and if youve read the links above, you know whats bad about what theyre selling. Still, I fear The Market may really believe that bad products are good enough. If thats true, its a sad day for the masses whove consigned themselves to suffer with DRM, but its also a sad day for me. Since Im already trying to be patent-free, I already see a limited market before me to support my ideals. If DRM becomes the standard, Cory and I might find ourselves without the same toys as the unenlightened kids down the block ...
The experimental and theoretical study of decision making in biological systems has led to the identification of fundamental biochemical circuits and networks with interesting dynamical behavior. Switch-like (or bistable) networks may be be particularly important as rudimentary decision engines [1]. Indeed, bistability has already been found in a wide range of regulatory networks involved in decision making (e.g., [2, 3]). This project involves exploring the costs and benefits of various bistable circuit architectures using a combination of theoretical and experimental tools. Cost-benefit-type analyses have been used previously in the study of biochemical systems [4] and have significant potential for understanding bistability and decison making in particular. The relevant costs and benefits may include energetic costs, circuit response time, stability, and cellular resource utilization (e.g., RNA polymerase and ribosomes). This work will form the basis for a general theory that could ...
SESSION INTRODUCTIONS Distributed and Intelligent Databases, P. Argos, H.-W Mewes and D. Frishman; Pacific Symposium on Biocomputing 2:3 (1997). Modern Concepts in Molecular Modeling, J. Bajorath and T.E. Klein; Pacific Symposium on Biocomputing 2:4-5 (1997). Extracting Biological Knowledge from DNA Sequences, F.M. De La Vega, D. Thieffry and J. Collado-Vides; Pacific Symposium on Biocomputing 2:6-7 (1997). Understanding and Predicting Protein Structure, D. Fischer, A. Godzik, S. Chung, S. Subbiah and R. Lathrop; Pacific Symposium on Biocomputing 2:8-13 (1997). Biopolymer Structures: Where Do They Come From? Where Are They Going? Evolutionary Perspectives on Biopolymer Structure and Function, R.A. Goldstein and E. Bornberg-Bauer; Pacific Symposium on Biocomputing 2:14-15 (1997). Computing with Biomolecules, T. Head and T. Yokomori; Pacific Symposium on Biocomputing 2:16-17 (1997). Computation in Biological Pathways, P.D. Karp and M. Riley; Pacific Symposium on Biocomputing 2:18 (1997). ...
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Several factors can shorten NAND flash memory durability, including some measures that vendors take to improve the life of their drives.
Typical application scenarios for NAND flash memory assume a service life of 3-5 years and in some cases even significantly longer. The flash type to be used (SLC, pSLC, MLC, TLC, QLC) is selected accordingly, which has the necessary endurance, i. e. the lifespan measured in erase and programming cycles. If the …
The present invention comprises a plurality of clock signals with an approximately 50% duty cycle and overlapping phases. The phases of the plurality of clocks are such that the phase of an individual clock signal overlaps the phase of an earlier clock signal by an amount equal to the overlap of the phase of the next clock signal. The present invention further comprises a plurality of clocked precharge (CP) logic gates coupled in series. An individual CP logic gate couples to an individual clock signal though the CP logic gates evaluate device. For the data flow through the individual CP logic gate, the logic gate receives its data input from an earlier CP logic gate in the series and passes to the next CP logic gate in the series. The earlier CP logic gate couples to an earlier phase clock signal, and the next CP logic gate couples to the next phase clock signal. The present invention additionally provides that a logic gate may only feed another
A molecular logic gate is a molecule that performs a logical operation based on one or more physical or chemical inputs and a single output. The field has advanced from simple logic systems based on a single chemical or physical input to molecules capable of combinatorial and sequential operations such as arithmetic operations i.e. moleculators and memory storage algorithms. For logic gates with a single input, there are four possible output patterns. When the input is 0, the output can be either a 0 or 1. When the input is 1, the output can again be 0 or 1. The four output bit patterns that can arise corresponds to a specific logic type: PASS 0, YES, NOT and PASS 1. PASS 0 always outputs 0, whatever the input. PASS 1 always outputs 1, whatever the input. YES outputs a 1 when the input is 1 and NOT is the inverse YES - it outputs a 0 when the input is 1. An example of a YES logic gate is the molecular structure shown below. A 1 output is given only when sodium ions are present in solution (1 ...
Download Logic Gate Simulator for free. Logic Gate Simulator is an open-source tool for experimenting with and learning about logic gates. Features include drag-and-drop gate layout and wiring, and user created integrated circuits.
The first example of a molecular logic gate based on selenourea/anion host-guest interaction that performs a ternary logic operation using an 1H-NMR easy to read response output is described here. Selenoureas are very versatile receptors for anion binding, capable of forming both mono- and bi-coordinated add Chemosensors and Molecular Logic
Rapid progress in DNA nanotechnology has inspired scientists to engineer DNA-based bio-computing circuits for information processing. Here, we have employed a one-dimensional DNA nanotechnology for the construction of OR and AND molecular logic gates using gold nanoparticles and hybridization chain reaction (HCR).
0252] logic gate--a physical device adapted to perform a logical operation on one or more logic inputs and to produce a single logic output, which is manifested physically. Because the output is also a logic-level value, an output of one logic gate can connect to the input of one or more other logic gates, and via such combinations, complex operations can be performed. The logic normally performed is Boolean logic and is most commonly found in digital circuits. The most common implementations of logic gates are based on electronics using resistors, transistors, and/or diodes, and such implementations often appear in large arrays in the form of integrated circuits (a.k.a., ICs, microcircuits, microchips, silicon chips, and/or chips). It is possible, however, to create logic gates that operate based on vacuum tubes, electromagnetics (e.g., relays), mechanics (e.g., gears), fluidics, optics, chemical reactions, and/or DNA, including on a molecular scale. Each electronically-implemented logic gate ...
A resonant soliton scheme to implement ultrafast optical logic gates using semiconductor, nonlinear directional couplers NLDC has been investigated numerically. It has been demonstrated that the resonant soliton logic gates meet fundamental requirements for digital optical logic devices logic level restoration, cascadability, and logical completeness. The operation of AND, OR, XOR, NOT, NOR, and NAND logic gates have been demonstrated in numerical simulations using 2 X 2 device configuration for a directional coupler. 3 X 3 NLDC design has been suggested to implement logically complete gates without necessity to cascade two or more couplers. Using 3 X 3 device configuration, an inventor NOT gate and a NOR gate have been implemented. The opening characteristics of the resonant soliton logic gates have been investigated numerically using 100 fs input pulses with 2 pie pulse area. It has been shown that the operating speed of all constructed gates is 2 Tbits, the operation is bit-rate flexible, the signal
Dive into the research topics of Simultaneous multichannel wavelength multicasting and XOR logic gate multicasting for three DPSK signals based on four-wave mixing in quantum-dot semiconductor optical amplifier. Together they form a unique fingerprint. ...
LESSON PLAN I. Objectives At the end of the lesson, 80% should be able to: A. Differentiate the three basic logic gates B. Construct truth tables for each
This book describes primary results on the leading edge of in silico and in vitro cancer research and summarizes the anticancer activity of pharmacologically important flavonols such as quercetin, morin, kaempferol, fisetin, galangin, diosmetin, and cianidanol. Natural products are a prime source of lead compounds suitable for further modification during drug development. Cancer drug discovery is a risky, costly, and resource-consuming process. In the modern arena, molecular computer modeling in anticancer drug development is utilized to speed up hit identification and optimization of the pharmacological profile. The first chapter of this book deals with computer-aided drug discovery and anticancer drug design using pharmacological active flavonols. In further chapters, the authors discuss the in vitro and in vivo advancement in anticancer research on important flavonols such as quercetin, morin, kaempferol, fisetin, galangin, diosmetin, and cianidanol. Anticancer advancement research related to ...
Generation of a large family of genetic logic gates for applications in biosensing and information processing.. Funded by BBSRC.. Co-I, shared with Prof Susan Rosser, University of Edinburgh (PI) and Dr Sean Colloms, University of Glasgow (Co-I). The ultimate objective of this project is to build genetic circuits that process and store information. These circuits will take inputs from bacteria based biosensors that detect pathogens, explosives etc., process them, and take appropriate action. Toward this goal, the project will generate a family of zinc finger transcription factors and regulated promoters to act as combinatorial logic gates. The output of these logic gates can be different fluorescence signals. To evaluate these genetic circuits, we will employ an integrated microfluidic - arrayed waveguide grating (AWG) device that is capable of simultaneous quantification of multiple wavelengths (figure 2). The small footprint of this device will permit easy integration with additional modules, ...
Last year, scientists managed to use the bacteria Escherichia coli to solve a mathematical problem, described in this research. This year, the building blocks of a computer are made.. Researchers at the UCSF School of Pharmacys Department of Pharmaceutical Chemistry, led by Christopher A. Voigt have just published a paper which promises to get your circuits moving. This team has been working with the same bacteria to build logic gates like the ones found in computers directly into cells, making it possible to rewire and program them. The simple logic gates used in the experiment were built into genes then inserted into E. coli cells. The logic gates then acted as the communicator between the separate strains, allowing them to be connected together. Via engadget.com. ...
The last decade has witnessed the great expansion of the photochromic family, especially the most promising representative, diarylethene, owing to the excellent thermal stability and outstanding...
Preface xi. Acknowledgements xiii. 1 Introduction to the Theory of Information 1. 1.1 Introduction 1. 1.2 Definition and Properties of Information 2. 1.3 Principles of Boolean Algebra 4. 1.4 Digital Information Processing and Logic Gates 7. 1.4.1 Simple Logic Gates 7. 1.4.2 Concatenated Logic Circuits 10. 1.4.3 Sequential Logic Circuits 11. 1.5 Ternary and Higher Logic Calculi 14. 1.6 Irreversible vs Reversible Logic 16. 1.7 Quantum Logic 18. References 20. 2 Physical and Technological Limits of Classical Electronics 23. 2.1 Introduction 23. 2.2 Fundamental Limitations of Information Processing 24. 2.3 Technological Limits of Miniaturization 27. References 34. 3 Changing the Paradigm: Towards Computation with Molecules 37. References 53. 4 Low-Dimensional Metals and Semiconductors 63. 4.1 Dimensionality and Morphology of Nanostructures 63. 4.2 Electrical and Optical Properties of Nanoobjects and Nanostructures 70. 4.2.1 Metals 70. 4.2.2 Semiconductors 84. 4.3 Molecular Scale Engineering of ...
Liposome logic - VLSI research, in its continuous push toward further miniaturisation, is seeking to break through the limitations of current circuit manufacture techniques by moving towards biomimetic methodologies that rely on self-assembly, selforganisation and evodevo-like processes. On the other hand, Systems and Synthetic biologys quest to achieve ever more detailed (multi)cell models are relying more and more on concepts derived from computer science and engineering such as the use of logic gates, clocks and pulse generator analogs to describe a cells decision making behavior. This paper is situated at the crossroad of these two enterprises. That is, a novel method of non-conventional computation based on the encapsulation of simple gene regulatory-like networks within liposomes is described. Three transcription Boolean logic gates were encapsulated and simulated within liposomes self-assembled from DMPC (dimyristoylphosphatidylcholine) amphiphiles using an implementation of Dissipative P...
Some embodiments of the invention provide a configurable integrated circuit (IC). The IC includes first and second circuits. The first circuit is a logic circuit for receiving configuration data sets and performing at least a first function when receiving a first configuration data set and a second function when receiving a second configuration data set. The second circuit communicatively couples to the first logic circuit. The second circuit is for supplying configuration data sets to the first logic circuit. The second circuit has a first set of input terminals. The integrated circuit also has a second set of input terminals for carrying data. Several the second set of input terminals overlap several of the first set of input terminals. The IC also has a set of vias, where each via connects an input terminal in the first set with an input terminal in the second set.
Predicting protein structure from sequence remains a major open problem in protein biochemistry. One component of predicting complete structures is the prediction of inter-residue contact patterns (contact maps). Here, we discuss protein contact map prediction by machine learning. We describe a novel method for contact map prediction that uses the evolution of logic circuits. These logic circuits operate on feature data and output whether or not two amino acids in a protein are in contact or not. We show that such a method is feasible, and in addition that evolution allows the logic circuits to be trained on the dataset in an unbiased manner so that it can be used in both contact map prediction and the selection of relevant features in a dataset.
Efforts to construct synthetic biological circuits with more complex functions have often been hindered by the idiosyncratic behavior, limited dynamic range and crosstalk of commonly utilized parts. Here, we employ de novo RNA design to develop two high-performance translational repressors with sensing and logic capabilities. These synthetic riboregulators, termed toehold repressors and three-way junction (3WJ) repressors, detect transcripts with nearly arbitrary sequences, repress gene expression by up to 300-fold and yield orthogonal sets of up to 15 devices. Automated forward engineering is used to improve toehold repressor dynamic range and SHAPE-Seq is applied to confirm the designed switching mechanism of 3WJ repressors in living cells. We integrate the modular repressors into biological circuits that execute universal NAND and NOR logic and evaluate the four-input expression NOT ((A1 AND A2) OR (B1 AND B2)) in Escherichia coli. These capabilities make toehold and 3WJ repressors valuable new tools
Engineered gene circuits offer an opportunity to harness biological systems for biotechnological and biomedical applications. However, reliance on native host promoters for the construction of circuit elements, such as logic gates, can make the implementation of predictable, independently functioning circuits difficult. In contrast, T7 promoters offer a simple orthogonal expression system for use in a variety of cellular backgrounds and even in cell-free systems. Here we develop a T7 promoter system that can be regulated by two different transcriptional repressors for the construction of a logic gate that functions in cells and in cell-free systems. We first present LacI repressible T7lacO promoters that are regulated from a distal lac operator site for repression. We next explore the positioning of a tet operator site within the T7lacO framework to create T7 promoters that respond to tet and lac repressors and realize an IMPLIES gate. Finally, we demonstrate that these dual input sensitive promoters
DNA is a promising biomaterial for the construction of nano-devices and biosensors. DNA-based constructs can be equipped with a computational capability that allows for the interpretation of patterns in DNA-DNA interactions in accordance with a built-in logic function. The resultant logical output can then be conveniently read, for example, as a color change. Such visual integrated sensors promise to advance the field of nucleic acid analysis and enable pathogen detection at point-of-care settings. Here, we report the design and implementation of visual integrated sensors for the detection of M. tuberculosis, a causative agent for tuberculosis disease. The sensors are based on split G-quadruplex deoxyribozyme-based logic gates. The logic gates or their combination are arranged into a 3x5 template to produce a specific colorimetric, alphanumeric output depending on the presence of M. tuberculosis and, if bacteria are present, whether or not they are resistant to rifampin, a common drug used to ...
Preface. Chapter 1 Introduction to CMOS Design.. Chapter 2 The Well.. Chapter 3 The Metal Layers.. Chapter 4 The Active and Poly Layers.. Chapter 5 Resistors, Capacitors, MOSFETs.. Chapter 6 MOSFET Operation.. Chapter 7 CMOS Fabrication by Jeff Jessing.. Chapter 8 Electrical Noise: An Overview.. Chapter 9 Models for Analog Design.. Chapter 10 Models for Digital Design.. Chapter 11 The Inverter.. Chapter 12 Static Logic Gates.. Chapter 13 Clocked Circuits.. Chapter 14 Dynamic Logic Gates.. Chapter 15 VLSI Layout Examples.. Chapter 16 Memory Circuits.. Chapter 17 Sensing Using ?S Modulation.. Chapter 18 Special Purpose CMOS Circuits.. Chapter 19 Digital Phase-Locked Loops.. Chapter 20 Current Mirrors.. Chapter 21 Amplifiers.. Chapter 22 Differential Amplifiers.. Chapter 23 Voltage References.. Chapter 24 Operational Amplifiers I.. Chapter 25 Dynamic Analog Circuits.. Chapter 26 Operational Amplifiers II.. Chapter 27 Nonlinear Analog Circuits.. Chapter 28 Data Converter Fundamentals by Harry ...
The language is based on Verilog, which is commonly used to program computer chips. To create a version of the language that would work for cells, the researchers designed computing elements such as logic gates and sensors that can be encoded in a bacterial cells DNA. The sensors can detect different compounds, such as oxygen or glucose, as well as light, temperature, acidity, and other environmental conditions. Users can also add their own sensors. Its very customizable, Voigt says.. The biggest challenge, he says, was designing the 14 logic gates used in the circuits so that they wouldnt interfere with each other once placed in the complex environment of a living cell.. In the current version of the programming language, these genetic parts are optimized for E. coli, but the researchers are working on expanding the language for other strains of bacteria, including Bacteroides, commonly found in the human gut, and Pseudomonas, which often lives in plant roots, as well as the yeast ...
setting starting conditions #g is starting group #m is max number of iterations #t is time #u is the number of nodes #v is the number of groups g = m = t = 0 u = x (where x is the number of nodes in the model) v = y (where y is the number of groups in the model) #implement node iterator nodeChecker(): timeStep(): t = t + 1 nodeExecute(p): #p is the number of groups to execute over, in the interval 1 ,= g ,= v (p=1 is group 1, p=2 is group 1 and 2, ...) execute all nodes inside selected group(s) timeStep() printResults(): print results of execution of nodes at time of execution print state of unexecuted groups (minus current group(s)) #print the seedValue states of network before execution at time t, execute nodes in g nodeExecute(1) printResults() at time t+1, execute nodes in g and g+1 nodeExecute(2) printResults() ... at time t = m, execute nodes in group g, g+1 ... g+(u-1) nodeExecute(g+(u-1)) printResults() stop execution ...
Design-and-Implementation-of-Phase-Frequency-Detector-Using-Different-Logic-Gates-in-CMOS-Process-Technology | Mini Projects | Electronics tutorial
The ninth edition of Scientia Pro Publica is up on Pleiotropy. Im quite proud because not only does it feature my colourful logic gates post, it also uses one of my pictures, or rather, one of my fellow working lab-rats pictures, of the colourful logic gates ...
A logic circuit generating method and apparatus generating logic circuits of a circuit system by minimizing the fan-out count of cells or cell macros constituting information specific to the circuit system. According to the method, a Boolean expression and the polarities of its input/output variables are input from a design master file of the apparatus. The Boolean expression is then transformed into a two-branch tree composed of nodes represented by the logical operators of that expression. In the two-branch tree, the nodes representing a parent and a child logical operator are converted into a single node, whereby a multiple-branch tree is generated. That is, a plurality of gates are connected to a single net, or signal line. A cell library is referenced so that cells are assigned initially to the multiple-branch tree thus obtained. The initial cell assignment is performed preferentially starting from the cell whose fan-out count is the largest. This
In the cellular automata simulation, the object under consideration is divided into small cells and the simulation is performed according to the local rule which is defined as the local relationship among cells. In this paper, the concept of cellular automata is applied to the design scheme of truss structures. First, truss elements are considered as the cells of the cellular automata and the local rule is derived from the optimization problem. The objective functions are defined to minimize the total weight of the structure and to obtain even stress distribution in the whole structure. The constraint conditions are introduced in order to define the local rule. The present method is applied to the design of the plane and the three-dimensional truss structures such as Schwedler and Lamella Domes. The convergence histories of the total weight and the mean and the maximum stresses are shown in order to discuss the property of the present method ...
Dynamic DNA complexes are able to undergo multiple hybridization and dissociation events through a process called strand displacement. This unique property has facilitated the creation of programmable molecular detection systems and chemical logic gates encoded by nucleotide sequence. This work examines whether the ability to selective exchange oligonucleotides among different thermodynamically-stable DNA complexes can be harnessed to create a new class of imaging probes that permit fluorescent reporters to be sequentially activated (turned on) and erased (turned off). Here, dynamic DNA complexes detect a specific DNA-conjugated antibody and undergo strand displacement to liberate a quencher strand and activate a fluorescent reporter. Subsequently, incubation with an erasing complex allows the fluorophore to be stripped from the target strand, quenched, and washed away. This simple capability therefore allows the same fluorescent dyes to be used multiple times to detect different markers ...
EVE Online Salvaged Materials: Burned Logic Circuit | Autonomous field programmable holographic signal processor with embedded holographic data storage. Used in most modern computers, the ubiquitous AFPHSPEHDS is colloquially known as the Aphid. This name leads of course to many bad puns about bugs in the system.
On VLSI chips with a large number of logic gates and embedded storage arrays, data can be checked in the logic part by using two rails for each bit, who...
Loregic is a computational method integrating gene expression and regulatory network data, to characterize the logical cooperativity of regulatory factors. Loregic uses all 16 possible two-input-one-output logic gates (e.g. AND or XOR) to describe triplets of two factors regulating a common target, and finds the gate that best matches each triplets observed gene expression pattern across many conditions. Using human ENCODE ChIP-Seq and TCGA RNA-Seq data, we are able to demonstrate how Loregic characterizes complex circuits involving both proximally and distally regulating transcription factors (TFs) and also miRNAs ...
21) Parallel and distributed processing across many neuron-like units can lead to complex behaviors (Rumelhart & McClelland - 1986, OReilly - 1996). Pitts & McCullochprovided amazing insight into how brain computations take place. However, their two-layer perceptrons were limited. For instance, they could not implement the logic gate XOR (i.e., one but not both). An extra layer was added to solve this problem, but it became clear that the Pitts & McCulloch perceptrons could not learn anything requiring more than two layers.. Rumelhart solved this problem with two insights.. First, he implemented a non-linear sigmoid function (approximating a neuronal threshold), which turned out to be essential for the next insight.. Second, he developed an algorithm called backpropagation of error, which allows the output layer to propagate its error back across all the layers such that the error can be corrected in a distributed fashion. See P.L.s previous post on the topic for further ...
Advanced redstone circuits encompass mechanisms that require complicated redstone circuitry. They are usually composed of many simpler components, such as logic gates. For simpler mechanisms, see electronic mechanisms, wired traps, and Redstone. Hi! In Minecraft, several in-game systems can...
Using the model described above, we considered the situation where two TFs (TF1 and TF2) converge on a single gene promoter that we name GSU (gonadotropin subunit), a generic term used because this is likely to be the case for the αGSU, LHβ and FSHβ gonadotropin subunit genes, as it is for many other ERK and NFAT target genes [8,9,29-33]. We considered the possibility that TF1 is an ERK-activated TF and that TF2 is NFAT (parallel activation network topology) or that TF1 and TF2 are sequentially activated downstream of ERK (sequential activation network topology). We also tested three distinct logic gates for the nature of the action of TF1 and TF2 at the promoter [35]. The first is a CO-OPERATIVE gate that, in biological terms, could reflect the action of one TF to mediate the interaction between the other TF and the cells transcriptional machinery, or alternatively, the requirement of physical interaction between the two TFs to orientate distant promoter sites and bring them to close ...
Small RNAs (sRNAs) can operate as regulatory agents to control protein expression by interaction with the 5 untranslated region of the mRNA. We have developed a physicochemical framework, relying on base pair interaction energies, to design multi-state sRNA devices by solving an optimization problem with an objective function accounting for the stability of the transition and final intermolecular states. Contrary to the analysis of the reaction kinetics of an ensemble of sRNAs, we solve the inverse problem of finding sequences satisfying targeted reactions. We show here that our objective function correlates well with measured riboregulatory activity of a set of mutants. This has enabled the application of the methodology for an extended design of RNA devices with specified behavior, assuming different molecular interaction models based on Watson-Crick interaction. We designed several YES, NOT, AND, and OR logic gates, including the design of combinatorial riboregulators. In sum, our de novo approach
I also found this illuminates why building satisfactory taxonomy systems in databases (like those that power CMSs like WordPress) might be so difficult: Categories in our minds are essentially analogies, with varying degrees of complexity, but which grow and morph in meaning as we gain experience and learn. The edges are inherently fuzzy, and our mental hardware is optimized to make connections between them easily. In computer systems with fixed data structures, categories must have to be fixed, with clear hard yes/no lines, and (unless you have the benefit of complicated machine learning algorithms) connections between them must be intentionally and explicitly crafted by programmers. At first this appeared to me as a fundamental alienating difference between biological and machine minds: Fixed, binary thought, versus flexible, analog (with its delicious shares root with analogy) thought. But, I suppose our own minds are built up of their own (however elegant and complicated) logic gate hardware ...
Accurate characterization of promoter behavior is essential for the rational design of functional synthetic transcription networks such as logic gates and oscillators. However, transcription rates observed from promoters can vary significantly depending on the growth rate of host cells and the experimental and genetic context of measurement. Further, in vivo measurement methods must accommodate variation in translation, protein folding and maturation rates of reporter proteins, as well as metabolic load. The external factors affecting transcription activity may be considered extrinsic, and the goal of characterization should be to obtain quantitative measures of the intrinsic characteristics of promoters. We have developed a promoter characterization method that is based on a mathematical model for cell growth and reporter gene expression and exploits multiple in vivo measurements to compensate for variation due to extrinsic factors. First, we used optical density and fluorescent reporter gene ...
British scientists have successfully demonstrated that the logic gates used for processing information can be built of harmless gut bacteria and DNA.
OncoSenX is a late stage pre-clinical cancer company. OncoSenX targets solid tumors based on transcriptional activity using a unique lipid nanoparticle and plasmid DNA. The next generation in cancer therapies will be more targeted with less side effects. At OncoSenX we believe the battle against cancer should be fought with genetic information. Our treatment delivers a simple program that induces apoptosis in cancerous cells. Our approach is a less invasive, more precise intervention for this complex and devastating disease. Our system is comprised of two main components: An untargeted non-toxic lipid nanoparticle and a highly targeted DNA payload. DNA plasmids encode an inducible death protein under a promoter that is active in the target cell population. We are initially targeting cells that are transcriptionally active for p53. Cells are killed via apoptosis with caspase 9. We can use our DNA payload to effectively implement logic gates (IF / OR / AND). This allows us to precisely target cell ...
The author of this thesis is Malte Schmitz.. Regular linear temporal logic (RLTL) combines the advantages of linear temporal logic (LTL) and ω-regular expressions in a new logic. To use RLTL in practise an efficient translation from RLTL into automata is needed. In the context of this thesis such a translation was implemented as a scala program, which reads in RLTL formulas and translates them into finite alternating two-way parity au- tomata. In this thesis the used translation and its implementation will be described in detail.. ...
The new function FindTransientRepeat identifies the transient and repeated parts of a list. It can be used to investigate cellular automata.. Look at the rule 30 cellular automaton (CA). The Version 11 function RulePlot is a useful tool to find the associated transformation rules. ...
Inferring Genetic Regulatory Interactions with Bayesian Logic-Based Model: 10.4018/978-1-60566-685-3.ch005: This chapter describes the model of genetic regulatory interactions. The model has a Boolean logic semantics representing the cooperative influence of
A process automatically generating topology data for fabricating large scale integrated circuits. Technology data, a logic function description and logic circuit components are generated and input to a data processing system together with geometric dimension data descriptive of the basic elements of the logic circuit components. The geometric dimension data is assembled into a plurality of intermediate level geometric topology patterns under control of the logic function description and the intermediate level geometric topology patterns are assembled into a prime level geometric topology representative of the logic function description. The logic circuit components are merged with the prime level geometric topology to produce a grid array to be fabricated into a large scale integrated circuit.
Pheromone-based internally optimizing resource gathering network simulation using automata inspired by ants. - sampottinger/simple_ant
These lectures describe a few dynamical properties of some statistical mechanics systems such as spin models, automata, neural networks. Two aspects will be mostly discussed: the multivalley...
Technology scaling poses an increasing challenge to the reliability of digital circuits. Hardware redundancy solutions, such as triple modular redundancy (TMR), produce very high area overhead, so partial redundancy is often used to reduce the overheads. Approximate logic circuits provide a general framework for optimized mitigation of errors arising from a broad class of failure mechanisms, including transient, intermittent, and permanent failures. However, generating an optimal redundant logic circuit that is able to mask the faults with the highest probability while minimizing the area overheads is a challenging problem. In this study, we propose and compare two new approaches to generate approximate logic circuits to be used in a TMR schema. The probabilistic approach approximates a circuit in a greedy manner based on a probabilistic estimation of the error. The evolutionary approach can provide radically different solutions that are hard to reach by other methods. By combining these two ...
but the normalized value of SMART attribute 177, wear leveling count, is the percentage of rated life left in the NAND cells. Edit: I see now that the author of one of the programs has said that the drive life is now based on 0xB1, wear leveling count, instead of some others. 0xB1 in hex is 177 in decimal, so it is the attribute I was referring to above. I would agree that this is a more fitting estimate of the drives remaining rated life. Id keep using it at 59% if it were mine.. SSDs have a rated number of write cycles they can endure, but reaching that point doesnt mean the NAND cells are actually dead. A Samsung 840 Pro was the torture test champion in TechReports torture test, where they wrote to the drives continuously until they failed. The drive made it to about 2 petabytes before it failed (2,000 TB)! It was rated for far less life than that.. If the drive has had uncorrectable errors (attribute 187), that means there was a hard failure in one or more NAND cells that could not be ...
OVERVIEW_[ ->. Discover the concepts of pushdown automata, Turing machines, and finite transducers in this 12-video course, in which learners can examine how to identify limitations and complexities in computation and how to apply P and NP classes to manage them. Begin by recalling the machine learning analytical capabilities of grammar, then look at context-free grammar normal forms, using Chomsky normal forms and Greibach normal forms to manage context-free grammars. Describe pushdown automata and features of nondeterministic pushdown automata. This leads on to Turing machines, their capabilities, and the prominent variations in the building themes of Turing machines. Learners explore the concept of finite transducers, and the types of finite transducers. Recall the underlying limitations of computations and the limitations of computational theory, and the complexities of computation, computational theory complexities, and how it can impact Turing machine models and language families. Learn ...
Recent advances in RNA sequencing technology can generate deep coverage data containing millions of reads. RNA-Seq data are used to identify genetic variants and alternatively spliced isoforms, a common mechanism for diversity in a gene, that may play a role in heritable traits and diseases. Using this type of data, connections can be drawn between genetic expression and one of the two parental haplotypes identified in a diploid organisms transcript. In other words, we can potentially identify the parent from which an individual inherited a group of genes.. These multi-kilobase reads are longer than most transcripts and enable sequencing of complete haplotype isoforms. New computational methods are required for efficient analysis of this highly complex data. In a recent paper, we present HapIso (Haplotype-specific Isoform Reconstruction), a comprehensive method that can accurately reconstruct the haplotype-specific isoforms of a diploid cell. Our software package is the first method capable of ...
Neuroblastoma, a clinically heterogeneous pediatric cancer, is characterized by distinct genomic profiles but few recurrent mutations. As neuroblastoma is expected to have high degree of genetic heterogeneity, study of neuroblastomas clonal evolution with deep coverage whole-genome sequencing of diagnosis and relapse samples will lead to a better understanding of the molecular events associated with relapse. Samples were included in this study if sufficient DNA from constitutional, diagnosis and relapse tumors was available for WGS. Whole genome sequencing was performed on trios (constitutional, diagnose and relapse DNA) from eight patients using Illumina Hi-seq2500 leading to paired-ends (PE) 90x90 for 6 of them and 100x100 for two. Expected coverage for sample NB0175 100x100bp was 30X for tumor and constitutional samples. For the seven other patients expected coverage was 80X for tumor samples with PE 100x100, 100X in the other tumor samples and 50X for all constitutional samples (see table ...
Nicole King, molecular biologist. *Jon Kleinberg, computer scientist. *Jonathan Lethem, novelist. *Michael Manga, geophysicist ...
"Jefferson Computer Museum. Retrieved February 20, 2013.. *^ "Network News Transfer Protocol". Internet Engineering Task Force. ... "The Most-Cited Institutions in Molecular Biology & Genetics, 1995-2005". Reuters. March 2006. Archived from the original on May ... "Best Computer Engineering Programs". U.S. News & World Report. 2013. Retrieved April 29, 2013.. ... 5th in molecular biology and genetics,[133][134] 17th in engineering,[135] and 18th in Neuroscience and Behavior[136] using non ...
Connolly, M. L. (1991). "Molecular interstitial skeleton". Computers and Chemistry. 15 (1): 37-45. doi:10.1016/0097-8485(91) ... Michel Sanner's Molecular Surface - the fastest program to calculate the excluded surface. pov4grasp render molecular surfaces ... Solvent accessible and molecular surface area and average curvature calculation. Free for academic use. ASA.py - a Python-based ... Leach, A. (2001). Molecular Modelling: Principles and Applications (2nd ed.). p. 7. Busa, Jan; Dzurina, Jozef; Hayryan, Edik ( ...
Computer Modeling in Engineering & Sciences Computers, Materials, & Continua Molecular & Cellular Biomechanics Advances in ... He founded the journals Computer Modeling in Engineering & Sciences (2000); Computers, Materials, & Continua (2004); Molecular ... Six out of the ten most highly cited papers in the journal CMES: Computer Modeling in Engineering & Sciences from 1999 to 2014 ... Atluri, S.N. (2005). Methods of Computer Modeling in Engineering & the Sciences. Tech Science Press. ISBN 0-9657001-9-4. Atluri ...
Protein Folding by Restrained Energy Minimization and Molecular Dynamics. In: Journal of Molecular Biology. Band 170, 1983, S. ... Protein Conformation, Dynamics and Folding by Computer Simulation. In: Annual Review of Biophysics and Bioengineering. Band 11 ... mit V. Daggett: Protein Unfolding Pathways Explored Through Molecular Dynamics Simulations. In: Journal of Molecular Biology. ... mit J. Janin, S. Wodak, B. Maigret: The Conformation of Amino Acid Side Chains in Proteins. In: Journal of Molecular Biology. ...
"Molecular Biochemistry I. Rensselaer Polytechnic Institute. Retrieved 2009-01-10.. *. Goodsell DS (2001-12-01). "Glycogen ... Journal of Chemical Information and Computer Science. 39: 1141-1150. doi:10.1021/ci9900332.. ... Nogales-Gadea G, Arenas J, Andreu AL (January 2007). "Molecular genetics of McArdle's disease". Curr Neurol Neurosci Rep. 7 (1 ... Molecular Genetics and Metabolism. 79 (2): 142-145. doi:10.1016/S1096-7192(03)00068-4. PMID 12809646.. ...
Among them, the School of Computer Science and Software Engineering is the amalgamation between the Department of Computer ... School of Chemistry and Molecular Engineering. *School of Science and Engineering. *School of Information Science and ...
Molecular Computer Simulations - Modeling of Lipid Membranes. *Lipids, Membranes and Vesicle Trafficking - The Virtual Library ... "International Journal of Molecular Sciences. 14 (2): 4242-82. doi:10.3390/ijms14024242. PMC 3588097. PMID 23429269.. ... "Nature Reviews Molecular Cell Biology. 9 (2): 112-24. doi:10.1038/nrm2330. PMC 2642958. PMID 18216768.. ... "Nature Structural & Molecular Biology. 18 (8): 886-893. doi:10.1038/nsmb.2081. PMC 3430870. PMID 21743455.. ...
Computer Chem. 1: 171-175. I. Gutman; B. Ruscic; N. Trinajstić; C.F. Wilcox Jr. (1975). "Graph theory and molecular orbitals. ... Computer Chem. 1: 171-175. I. Gutman; M. Milun; N. Trinajstić (1977). "Graph Theory and Molecular Orbitals. XIX. Non-Parametric ... In quantum chemistry he worked on semi-empirical molecular orbital theory and settling conjugated-circuit model on a firm ... He wrote the first monograph on chemical graph theory and introduced several molecular descriptors such as 3-dimensional Wiener ...
Molecular and cellular biology ; Computer science ; Physiology ; Chemistry ; Biochemistry ; Microbiology ; Nine practical work ...
Trends in Molecular Medicine. 19 (10): 583-585. doi:10.1016/j.molmed.2013.07.010. PMC 4418476. PMID 23953478. Türkay, Selen ( ... Computers & Education. 98: 102-114. doi:10.1016/j.compedu.2016.03.004. Halliday, Josh (21 October 2011), "Internet users get ...
Evans, Denis J.; Morriss, Gary P. (1984). "Non-Newtonian molecular dynamics". Computer Physics Reports. North-Holland. 1 (16): ... CS1 maint: discouraged parameter (link) "SklogWiki Non-equilibrium Molecular Dynamics". Retrieved 4 May 2020. CS1 maint: ... computer simulation algorithms for nonequilibrium systems, the relation of the intermolecular potential function to macroscopic ... and his development of algorithms for nonequilibrium molecular dynamics simulations. Evans has over 350 publications on ...
Danos V, Laneve C (2004). "Formal molecular biology". Theoretical Computer Science. 325: 69-110. doi:10.1016/j.tcs.2004.03.065 ... Lecture Notes in Computer Science. Lecture Notes in Computer Science. 6501: 240-256. doi:10.1007/978-3-642-18123-8_19. ISBN 978 ... A molecular species with several of those features can therefore exist in a large number of possible states. For instance, it ... When used in this way, a slot is a placeholder for a subunit or a molecular component of a complex, and the state of the slot ...
"Best Computer Engineering Programs". U.S. News & World Report. 2013. Archived from the original on April 16, 2013. Retrieved ... "The Most-Cited Institutions in Molecular Biology & Genetics, 1995-2005". Reuters. March 2006. Archived from the original on May ... Engineering, particularly computer science, became an important part of the university's academics as it matured. University ... "The UCSD P-System Museum". Jefferson Computer Museum. Archived from the original on July 17, 2012. Retrieved February 20, 2013 ...
Yu H, van Gunsteren WF (November 2005). "Accounting for polarization in molecular simulation". Computer Physics Communications ... Comparison of force field implementations Molecular dynamics Molecular mechanics Molecular design software Molecular modelling ... VAMM (Virtual atom molecular mechanics) - a coarse-grained force field developed by Korkut and Hendrickson for molecular ... a full periodic table force field for molecular mechanics and molecular dynamics simulations". Journal of the American Chemical ...
Computer Sciences 1. Mathematics 2. Astronomy and physics 3. Chemistry 4. Engineering 5. Earth science and environmental ... science 6. Biochemistry and molecular cell biology 7. Microbiology, immunology and developmental biology 8. Anatomy, physiology ...
Math.Computer Chem. 1: 171-175. I. Gutman; B. Ruscic; N. Trinajstić; C.F. Wilcox Jr. (1975). "Graph theory and molecular ... A. Graovac; I. Gutman; N. Trinajstić; T. Živković (1972). "Graph theory and molecular orbitals: Application of Sachs theorem". ... I. Gutman; M. Milun; N. Trinajstić (1977). "Graph Theory and Molecular Orbitals. XIX. Non-Parametric Resonance Energies of ... I. Gutman (1994). "Selected properties of the Schultz molecular topological index". J. Chem. Inf. Comput. Sci. 34 (5): 1087- ...
Kahan, M.; Gil, B.; Adar, R.; Shapiro, E. (2008). "Towards molecular computers that operate in a biological environment". ... Also available here: An autonomous molecular computer for logical control of gene expression ... "An autonomous molecular computer for logical control of gene expression". Nature. 429 (6990): 423-429. Bibcode:2004Natur.429.. ... DNA computers are faster and smaller than any other computer built so far. Furthermore, particular mathematical computations ...
Journal of Computer-aided Molecular Design. 25 (1): 51-66. Bibcode:2011JCAMD..25...51S. CiteSeerX 10.1.1.688.2670. doi:10.1007/ ... Braden, M. R.; Parrish, J. C.; Naylor, J. C.; Nichols, D. E. (2006). "Molecular interaction of serotonin 5-HT2A receptor ... European Journal of Nuclear Medicine and Molecular Imaging. 38 (4): 681-693. doi:10.1007/s00259-010-1686-8. PMID 21174090.. .mw ... residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists". Molecular Pharmacology. 70 (6): 1956 ...
"Journal of Computer-Aided Molecular Design. 26 (1): 15-26. doi:10.1007/s10822-011-9517-y. PMC 3268975. PMID 22183577.. ... Molecular modelling[28] and molecular dynamics simulations can be used as a guide to improve the potency and properties of new ... "International Journal of Molecular Sciences. 13 (10): 12857-79. doi:10.3390/ijms131012857. PMC 3497300. PMID 23202926.. ... Barcellos GB, Pauli I, Caceres RA, Timmers LF, Dias R, de Azevedo WF (December 2008). "Molecular modeling as a tool for drug ...
Journal of Computer-Aided Molecular Design. 18 (3): 189-208. Bibcode:2004JCAMD..18..189M. doi:10.1023/B:JCAM.0000035199.48747. ... rDock - The Molecular Docking Platform (University of York). *rDock - A Fast, Versatile and Open Source Program for Docking ... rDock (previously RiboDock) is an open-source molecular docking software that be used for docking small molecules against ...
Journal of Computer-aided Molecular Design. 25 (1): 51-66. CiteSeerX 10.1.1.688.2670. doi:10.1007/s10822-010-9400-2. PMID ... European Journal of Nuclear Medicine and Molecular Imaging. 38 (4): 681-93. doi:10.1007/s00259-010-1686-8. PMID 21174090.. ...
... for example in molecular dynamics, for VLSI circuit simulation, and in computer graphics. They are also applied in the context ... Michels, Dominik L.; Desbrun, Mathieu (2015). "A Semi-analytical Approach to Molecular Dynamics". Journal of Computational ... ISBN 978-3-319-09062-7. Luan, Vu Thai; Ostermann, Alexander (2016). "Parallel exponential Rosenbrock methods". Computers and ... IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems. 32 (8): 1180-1193. doi:10.1109/TCAD.2012.2189396 ...
Tom Cleaver reviewed the game for Computer Gaming World, and stated that "I thoroughly recommend Microbe to gamers of every ... a molecular approach. ... Computer Gaming World. 1 (9): 41-42. Review in Softalk Review ...
In made also a major work with computing and the development of the computer, he suggested and described a computer ... Molecular biology, RNA); Melvin Calvin (Calvin Cycle); Otto Wallach (Alicyclic compound); Paul Berg (biochemistry of nucleic ... In the fields of mathematics and computer science, 31% of Turing Award recipients and 27% of Fields Medal in mathematics were ... Colossus computer); Carl Gustav Jacob Jacobi (Jacobi elliptic functions, Jacobian matrix and determinant, Jacobi symbol). ...
He became a pioneer in the field of computer-aided molecular design. He was the first to produce coloured images modelling ... 1989). Computer-aided molecular design. London: IBC Technical Services. ISBN 978-0895737380. Grant, Guy H.; Richards, W. Graham ... Richards is a pioneer in the field of computer-aided molecular design, in particular its application to the pharmaceuticals ... In 1982, Richards became a founding member of the Molecular Graphics Society (now the Molecular Graphics and Modelling Society ...
Monte Carlo integration Metropolis algorithm Importance sampling Quantum Monte Carlo Monte Carlo molecular modeling Allen, M.P ... Tildesley, D.J. (1987). Computer Simulation of Liquids. Oxford University Press. ISBN 0-19-855645-4. Frenkel, D. & Smit, B. ( ... which is used to simulate molecular chains) is generally employed. The main motivation for its use is the fact that, with the ... 2001). Understanding Molecular Simulation. Academic Press. ISBN 0-12-267351-4. Binder, K. & Heermann, D.W. (2002). Monte Carlo ...
Computer program and documentation". pp. 1216-23. Drummond A, Suchard MA, Xie D, Rambaut A (2012). "Bayesian phylogenetics with ... Minh BQ, Nguyen MA, von Haeseler A (May 2013). "Ultrafast approximation for phylogenetic bootstrap". Molecular Biology and ... Jobb G, von Haeseler A, Strimmer K (June 2004). "TREEFINDER: a powerful graphical analysis environment for molecular ... Huson DH, Bryant D (February 2006). "Application of phylogenetic networks in evolutionary studies". Molecular Biology and ...
"Computer simulation of electroscopes". Molecular Workbench. Concord Consortium. "Pith Ball and Charged Rod Video". St. Mary's ...
He then joined the PhD program in computer science at the University of Utah and worked at the Scientific Computing and Imaging ... He was the primary developer of SPaSM (Scalable Parallel Short-range Molecular dynamics), for which he won the IEEE Gordon Bell ... "Petascale Molecular Dynamics on Roadrunner" (PDF). Science Highlights. Los Alamos National Laboratory. Retrieved 24 May 2017. ... Following his PhD in 1998, he joined the Computer Science Department at the University of Chicago, and received a National ...
We know from molecular biology that distinct parts of the nervous system release distinct chemical cues, from growth factors to ... Brain-computer interface. *Neural development. *Neural network (artificial). *Neural network (biological). *Detection theory ...
Methods in Molecular Biology, Springer US, pp. 15-25, doi:10.1007/978-1-4939-9865-4_3, ISBN 9781493998654. , PMID 31541435. ... A list of computer programs for genetic analysis including QTL analysis. *Quantitative Trait Locus (QTL) Analysis @ Scitable ... Methods in Molecular Biology, Springer US, 2072, pp. 15-25, doi:10.1007/978-1-4939-9865-4_3, ISBN 9781493998654. , PMID ... QTLs are mapped by identifying which molecular markers (such as SNPs or AFLPs) correlate with an observed trait. This is often ...
2003). "11C-metomidate PET imaging of adrenocortical cancer". European Journal of Nuclear Medicine and Molecular Imaging. 30 (3 ... Three-dimensional images of tracer concentration within the body are then constructed by computer analysis. In modern PET ... Crump Institute for Molecular Imaging. Archived from the original (PDF) on May 18, 2015.. ... Imaging infections with molecular imaging technologies can improve diagnosis and treatment follow-up. PET has been widely used ...
Klenk, Hans-Dieter; Feldmann, Heinz (2004). Ebola and Marburg viruses: molecular and cellular biology (Limited preview). ... been misused to spread computer malware.[229] The BBC reported in 2015 that "North Korean state media has suggested the disease ... Trends in Molecular Medicine. 12 (5): 206-15. doi:10.1016/j.molmed.2006.03.006. PMID 16616875.. ...
This computer analysis makes it possible to detect and quantify abnormal brain organization, to give a quantitative definition ... This was due in part to the advent of inexpensive methods of linking computers to traditional EEG devices. This allowed ... Molecular cellular cognition. *Motor control. *Neurolinguistics. *Neuropsychology. *Sensory neuroscience. *Social cognitive ...
Molecular biology is the study of molecular underpinnings of the process of replication, transcription and translation of the ... Health informatics is a relatively recent field that deal with the application of computers and information technology to ... Many modern molecular tests such as flow cytometry, polymerase chain reaction (PCR), immunohistochemistry, cytogenetics, gene ... the knowledge of what happens at the cellular and molecular level in the tissues being stitched arises through science. ...
Genome complexity has generally increased since the beginning of the life on Earth.[17][18] Some computer models have suggested ... Stoltzfus, Arlin (1999). "On the Possibility of Constructive Neutral Evolution". Journal of Molecular Evolution. 49 (2): 169- ... Lecture Notes in Computer Science. Springer Berlin Heidelberg. pp. 289-308. doi:10.1007/978-3-642-27654-5_22. ISBN ... Cellular and Molecular Life Sciences. 72 (21): 4063-4076. doi:10.1007/s00018-015-1990-3. ISSN 1420-682X.. ...
Molecular Biology & Genetics. 74 Neuroscience & Behavior. 81 Oncology. 16 Pharmacology & Toxicology. 50 ... Computer Science. 181 Economics & Business. 54 Engineering. 69 Environment/Ecology. 83 Geosciences. 80 ...
... in conjunction with a computer to create images of both soft and hard tissues. These images look as though the patient was ...
History of Computer Graphics series of articles. University groups[edit]. *Computer Graphics Usability and Visualization Group ... Computer Graphics and User Interfaces Lab at Columbia University. *High Performance Computer Graphics Lab at Purdue University ... Computer Graphics and Visualization Lab at University of Utah. *Computer Graphics and Visualization Lab at University of ... Computer graphics is a sub-field of computer science which studies methods for digitally synthesizing and manipulating visual ...
Another computer scientist translated an old article in the Swedish technical journal Ny Teknika. Taubes says: "Ny Teknika ... molecular resonance excitation']", Huizenga 1993, pp. 6-7, 35-36, 75, 108-109, 112-114, 118-125, 130, 139, 173, 183, 217-218, ... Taubes 1993, p. 214 says the similarity was discovered on 13 April 1991, by a computer scientist and disseminated via the ...
Methods in Molecular Biology. 1402. Springer New York. pp. 119-134. doi:10.1007/978-1-4939-3378-5_10. ISBN 9781493933761. . ... Q-FISH combines FISH with PNAs and computer software to quantify fluorescence intensity. This technique is used routinely in ... Fluorescence in situ hybridization (FISH) is a molecular cytogenetic technique that uses fluorescent probes that bind to only ... FISH, on the other hand, does not require living cells and can be quantified automatically, a computer counts the fluorescent ...
Advancements in computer science found applications designing and managing plants, simplifying calculations and drawings that ... Models often involve separate considerations for macroscopic, microscopic and molecular level phenomena. Modeling of transport ... Both applied and research facets could make extensive use of computers.[35] ...
An online monitor computer located in the control room reads data from the DAQ host computer via an FDDI link. It provides ... is introduced to remove particles whose minimum size corresponds to molecular weight approximately 10,000 (or about 10 nm ... The computer system consists of 3 major sub-systems: the data server, the CPU farm and the network at the end of Run I.[7] ... The offline processing system is designed platform-independent because different computer architectures are used for data ...
Molecular communication. *Radio waves *wireless. *Transmission line *data transmission circuit. *telecommunication circuit ...
There was also a suggestion to create a "C" journal for molecular sciences to attract more authors in that area, but the idea ... the Publishing Section acquired its first computer for administration; the Transactions were first published online in 1997.[3] ...
Molecular Evolution. ISBN 978-0878934805.. *↑ Pop, M. (2004). "Shotgun Sequence Assembly" (PDF). Advances in Computers 60. ISSN ... 2006). Handbook of Computational Molecular Biology (en inglés). Computer and Information Science Series. Chapman & Hall/Crc. ... Genetics Computer Group - GCG, Oxford Molecular Group, Ltd.), e que, en xeral, experimentarán importantes transformacións anos ... "Journal of Molecular Biology 302 (1): 205-217.. *↑ Roberts, L. (2001). "A History of the Human Genome Project". Science 291 ( ...
Hence, semiconductors form the basis of the traditional computer. This field also includes new areas of research such as ... This involves simulating materials at all length scales, using methods such as density functional theory, molecular dynamics, ... The prominent change in materials science during the recent decades is active usage of computer simulations to find new ... and another variety called ultra-high-molecular-weight polyethylene (UHMWPE) is an engineering plastic which is used ...
... and professor of computer science at the New York University Courant Institute of Mathematical Sciences (b. 1930). 11 March - ... American scientist who played a central role in the early history of molecular biology (b. 1912). 29 October - Bei Shizhang, ... British physicist and computer scientist (b. 1918). 3 December - Brian Harold Mason, New Zealand-born geochemist and ... President of the International Society for Molecular and Cell Biology and Biotechnology Protocols and Researches (ISMCBBPR). ( ...
Aquarius houses sophisticated lab equipment and computers, enabling scientists to perform research and process samples without ...
... applied among the others in molecular biology[17] and thermodynamic non-equilibrium processes.[18] ... Helsinki University of Technology Laboratory of Computer and Information Science ... Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403 USA ... Helsinki University of Technology Laboratory of Computer and Information Science ...
Cellular and Molecular Life Sciences (CMLS). 54 (4): 305-308. doi:10.1007/s000180050156.. ... Lecture Notes in Computer Science. 10255: 259-266. doi:10.1007/978-3-319-58838-4_29. ISBN 978-3-319-58837-7.. ... Garrett RA; Klenk H (2005). Archaea: Evolution, Physiology and Molecular Biology. WileyBlackwell. ISBN 1-4051-4404-1.. ... Cavicchioli R (2007). Archaea: Molecular and Cellular Biology. American Society for Microbiology. ISBN 1-55581-391-7.. ...
In Computer Science and Software Engineering (JCSSE), 2012 International Joint Conference on: 276-282. doi:10.1109/JCSSE. ... Tom Strachan; Andrew Read (2 April 2010). Human Molecular Genetics. Garland Science. p. 45. ISBN 978-1-136-84407-2.. ... Molecular Psychiatry. 20: 140-147. doi:10.1038/mp.2014.145. PMID 25421402.. ...
Bruce Stillman, molecular biologist, Fellow of the Royal Society, Member of the National Academy of Sciences, EMBO and AAAS. ... computer science, statistics, and physics to problems in biology. ... Michael Wigler, genetic engineering of animal cells and molecular biologist, Member of the National Academy of Sciences and ... CSHL is ranked among the leading basic research institutions in molecular biology and genetics with Thomson Reuters ranking it ...
SG Biofuels, a San Diego-based jatropha developer, has used molecular breeding and biotechnology to produce elite hybrid seeds ... Brain-computer interface. *Electroencephalography. *Mind uploading *Brain-reading. *Neuroinformatics. *Neuroprosthetics *Bionic ...
RG-62 is a 93 Ω coaxial cable originally used in mainframe computer networks in the 1970s and early 1980s (it was the cable ... In 1980s and early 1990s coaxial cable was also used in computer networking, most prominently in Ethernet networks, where it ... While formerly common for implementing computer networks, in particular Ethernet ("thick" 10BASE5 and "thin" 10BASE2), twisted ... Its applications include feedlines connecting radio transmitters and receivers with their antennas, computer network (Internet ...
... to a wireless computer system it developed to assist nursing.[88] ... Molecular graphics. *Product visualization. *Scientific visualization. *Software visualization. *Technical drawing. *User ...
Boulpaep EL, Boron WF (2005). Medical physiology: a cellular and molecular approach. St. Louis, Mo: Elsevier Saunders. p. 90. ... Computer simulations of the dynamic behavior of receptors have been used to gain understanding of their mechanisms of action. ... Molecular Pharmacology. 64 (6): 1271-6. doi:10.1124/mol.64.6.1271. PMID 14645655.. ...
"A force of nature: molecular mechanisms of mechanoperception in plants". Journal of Experimental Botany. 64 (15): 4663-4680. ...
Biological computer can decrypt images stored in DNA February 8, 2012 at 9:44 am Californian and Israeli researchers have ... Microscopic machine mimics the ribosome, forms molecular assembly line January 14, 2013 at 11:06 am The human race has figured ... scientists have created a tiny machine that acts as something of an assembly line on the molecular level. ... created a biological computer - a machine made from biological molecules - that successfully decoded two images stored and ...
New molecular computers find the right cells. Artists depiction of Co-LOCKR on a cell with the right combination of cell ... the link above and choose the option that will save the file or target to your computer. ...
... scientists have used a quantum computer to calculate the precise energy of molecular hydrogen. This groundbreaking approach to ... When a quantum computer is put to work on a problem, it considers all possible answers by simultaneously arranging its qubits ... "Because classical computers dont scale efficiently, if you simulate anything larger than four or five atoms -- for example, a ... Rather than using binary bits labeled as "zero" and "one" to encode data, as in a conventional computer, quantum computing ...
Lipton, R. J., and E. B. Baum, eds., DNA Based Computers, DIMACS Series in Discrete Mathematics, and Theoretical Computer ... In 1994, L. M. Adelman used standard molecular biology techniques to find a Hamiltonian path through a map of 7 interconnected ... Adelman, L. M. Molecular computation of solutions to combinatorial problems, Science 226, 1021-1024 (1994). ... This is easily accomplished using gel electrophoresis for which the mobility is inversely proportional to the molecular mass. ...
... computer-aided design, design analysis, design implementation, simulation and testing. Theory as well as applications are ... Multilevel Algorithms for Large-scope Molecular Dynamics Simulations of Nanostructures on Parallel Computers. Aiichiro Nakano, ... Molecular Dynamics (MD) is a powerful tool for the atomistic understanding of longrange stress-mediated phenomena, phonon ... Concurrent Computing Laboratory for Materials Simulations, Department of Computer Science, Department of Physics and Astronomy ...
Molecular aspects of innate and adaptive immunity. [G Arlaud; Mike Carroll; Alister Dodds; Uffe Holmskov; Jens Chr Jensenius; ... Molecular aspects of innate and adaptive immunity. Author:. G Arlaud; Mike Carroll; Alister Dodds; Uffe Holmskov; Jens Chr ... Internet Resource, Computer File. All Authors / Contributors:. G Arlaud; Mike Carroll; Alister Dodds; Uffe Holmskov; Jens Chr ... schema:name "Molecular aspects of innate and adaptive immunity" ;. schema:numberOfPages "312" ;. schema:productID "873741778" ; ...
Molecular Design provides a form for disseminating information on both the theory and the application of computer-based methods ... computer and molecular graphics;. molecular modeling;. protein engineering;. drug design;. expert systems;. general structure- ... molecular dynamics;. chemical database development and usage. Contributions on computer-aided molecular modeling studies in ... The Journal of Computer-Aided Molecular Design provides a form for disseminating information on both the theory and the ...
... 28.08.2013. Renowned Experts Discuss the Future of ... Further reports about: , MRI , MeVis , Medical Wellness , Molecular Target , PET scan , Ultrasound , diagnostic methods , ... MRI »MeVis »Medical Wellness »Molecular Target »PET scan »Ultrasound »diagnostic methods »innovations ... In the future, computers could offer useful support. Researchers have already developed programs to employ patterns to search ...
... Who: 8th Grade Physical Science. Where: Upper School Macintosh Laboratory. When: Fall ... 1. My research was driven by the theory that computer-based molecular modeling is useful in understanding the surface ... Why: To foster student appreciation for-and understanding of-the way scientists use computers to model molecules.. A. ... As all computer simulations are idealized representations of the real world, a certain purity of assumption places limitations ...
Computer Analysis of Protein and Nucleic Acid Sequences, Volume 183 - 1st Edition. Print Book & E-Book. ISBN 9780121820848, ... Molecular Evolution: Computer Analysis of Protein and Nucleic Acid Sequences, Volume 183 1st Edition. 0.0 star rating Write a ... W.-H. Li and M. Gouy, Statistical Tests of Molecular Phylogenies.. R.F. Doolittle and D.-F. Feng, Nearest Neighbor Procedure ... from:Praise for the Volume @qu:"This contribution is really innovating in the domain of molecular biology and we can only ...
Researchers have developed a molecular computer, which uses enzymes to perform calculations from within the human body and to ... Molecular computers have the potential to surpass the speed and power of existing silicon computers because they can perform ... Computer Related Injuries. Computer- related injury (CRI) is a cluster of work-related symptoms in computer users such as ... Molecular Computer Developed To perform Calculations From Within Human Body. by Medindia Content Team on February 25, 2006 at 7 ...
... Using MacMolecule The basics MacMolecule2 and PCMolecule2 are designed for use by ... For more details on how to use this software, an on-line user manual is also available at the Molecular Ventures web site at ...
Part of the fun surrounding this incredible computer microscope is the hunt for exciting specimens to image. Small insects such ... Specimen illumination intensity is a critical factor in reflected darkfield microscopy using the Intel QX3 computer microscope ...
SC.edu » CEC » Computer Science & Engineering » Graduate. Rothberg Fellowships in Computational Molecular Biology. The ... Rothberg Fellowships in Computational Molecular Biology (a fund established in 2001 for up to three fellowships). ... Department of Computer Science and Engineering at the University of South Carolina invites applications for two Henry M. ...
Illumination provided by the Intel Play QX3 Computer Microscope is often not adequate to properly image specimens. We discuss ... The default illumination mode for the Intel Play QX3 Computer Microscope is either transmitted or reflected brightfield. When ...
Course "Bioinformatics: computer methods in molecular and systems biology". Trieste, Italy25 -29 June 2018 ...
... chemical and computer companies have formed a San Diego-based consortium to conduct basic research into computer-aided ... Biosym plans to add the new computer programs generated by the consortium to its line of molecular computer modeling tools. ... Molecular research is "just entering an era . . . where scientists can use computers to experiment with different variations ... Biosym is a small, privately held San Diego-based company that develops molecular computer modeling tools for the chemical ...
Further development of molecular machines are performing using B3PW91\6-311G** geometry optimization of larger molecular robots ... Ninth Foresight Conference on Molecular Nanotechnology.. There will be a link from here to the full article when it is ... The most stable molecular logic gates are investigating using B3PW91\6-311G**-TD method searching for charge transfer in ... Theoretical Molecular Electronics Research Group. Institute of Theoretical Physics and Astronomy, A. Gostauto 12, Vilnius 2600 ...
Emergence and Molecular Diversity via Information Theory: 10.4018/978-1-4666-2077-3.ch009: Numerous definitions for complexity ... "Complexity, Emergence and Molecular Diversity via Information Theory." In Complexity Science, Living Systems, and Reflexing ... "Complexity, Emergence and Molecular Diversity via Information Theory." Complexity Science, Living Systems, and Reflexing ... Complexity, Emergence and Molecular Diversity via Information Theory. Francisco Torrens (Institut Universitari de Ciència ...
BCL Molecular Computer. The BCL Molecular Computer was first introduced in 1971 and was sold and used in various forms until ... This is the distributor version of the Molecular - with its covers off. Its neat and more modern looking, but basically the ... If you have any memories of using a BCL Molecular or know if any survive, please contact us.. ...
Molecular and Materials Physics and Physical Chemistry) of Computer Physics Communications using our... ... Chemical, Molecular and Materials Physics and Physical Chemistry, Computer Physics Communications University of Southern ... Please note that all enquiries should relate specifically to Computer Physics Communications. ...
BIOSYM/Molecular Simulations develops and markets Computer-Aided Molecular Science (CAMS) applications software to researchers ... University of Chicago receives $10 million in computer software from BIOSYM/Molecular Simulations. The University of Chicago ... University scientists will use the software for computer-aided molecular modeling and simulation, and they will work with ... 10 million in computer software from San Diego-based BIOSYM/Molecular Simulations under a cooperative research and development ...
tags: brain-computer interface x microbiology x cell & molecular biology x The Scientist. » brain-computer interface , ...
Computer-Aided Molecular Design of Bis-phosphine Oxide Lanthanide Extractants. Title. Computer-Aided Molecular Design of Bis- ...
Molecular Docking is widely used in CADD (Computer-Aided Drug Designing), SBDD (Structure-Based Drug Designing) and LBDD ( ... Role of Molecular Docking in Computer-Aided Drug Design and Development: 10.4018/978-1-5225-0362-0.ch001: ... "Role of Molecular Docking in Computer-Aided Drug Design and Development." In Applied Case Studies and Solutions in Molecular ... "Role of Molecular Docking in Computer-Aided Drug Design and Development." Applied Case Studies and Solutions in Molecular ...
Understanding molecular etiology of the disease is a key step to devel...,Computer,simulations,point,to,key,molecular,basis,of, ... In CF the molecular basis of this increased misfolding tendency has r... ... A computer for your mouse!. 4. New approach builds better proteins inside a computer. 5. Computer solution to delivery problem ... Computer savvy canines. 9. Brain-computer link systems on the brink of breakthrough, study finds. 10. Computer learns dogspeak ...
The Masters of Engineering program in Computer Science and Molecular Biology (6-7P) is modeled on the existing Masters of ... 6-7 MEng Degree Program in Computer Science and Molecular Biology. SHARE: ... Electrical Engineering and Computer Science MEng Programs require 4 subjects totalling 42 units as described in the following ... MIT Electrical Engineering & Computer Science , Room 38-401 , 77 Massachusetts Avenue , Cambridge, MA 02139 ...
... created a biologically powered circuit that is integrated on a molecular level. ... Columbia scientists create first-ever computer chip integrated with biology on a molecular level. Share Pin Tweet ... Columbia scientists create first-ever computer chip integrated with biology on a molecular level Innovation. ... The team figured out how to utilize the molecular machinery of living systems to power an integrated circuit. Unlike any that ...
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  • Because classical computers don't scale efficiently, if you simulate anything larger than four or five atoms -- for example, a chemical reaction, or even a moderately complex molecule -- it becomes an intractable problem very quickly," says author James Whitfield, research assistant in chemistry and chemical biology at Harvard. (redorbit.com)
  • In 1994, L. M. Adelman used standard molecular biology techniques to find a Hamiltonian path through a map of 7 interconnected vertices. (jrank.org)
  • The Department of Computer Science and Engineering at the University of South Carolina invites applications for two Henry M. Rothberg Fellowships in Computational Molecular Biology (a fund established in 2001 for up to three fellowships). (sc.edu)
  • University of Chicago scientists are making important contributions in molecular modeling and materials research in fields ranging from molecular biology and cancer research to chemistry, geophysics and materials science. (uchicago.edu)
  • In response to the strong interest of MIT students in educational programs at the interface of classical engineering disciplines and the life sciences-in particular, in the EECS 6-7 degree program-and the need for a Masters in Engineering program in this area, the Departments of Biology and Electrical Engineering and Computer Science at MIT offer the MEng in 6-7 ( 6-7P ). (mit.edu)
  • The Masters of Engineering program in Computer Science and Molecular Biology (6-7P) is modeled on the existing Masters of Engineering program in EECS (6-P) and uses the same admissions criteria (i.e. (mit.edu)
  • Professor Segel, author of the highly acclaimed Modeling Dynamic Phenomena in Molecular and Cellular Biology, in conjunction with Professor Odell, has now produced on disc a series of programs which, together with the accompanying manual, will form an invaluable teaching and research tool, designed to integrate computer usage into a course on mathematical modelling for biologists. (cambridge.org)
  • The increase in our understanding of the molecular biology of malignant cells and viruses has now enabled researchers to design viruses that are capable of selectively destroying cancer cells and spare normal surrounding tissue. (worldcat.org)
  • With this new method, it is now possible to perform computer simulations of systems-level molecular biology to formulate questions about fundamental life processes, the cellular impacts of genetic manipulation or to quantitatively analyze gene expression data," said Joshua Lerman, a Ph.D. candidate in Palsson's Systems Biology Research Group. (healthcanal.com)
  • A brief introductory primer on molecular biology and Al gives computer scientists sufficient background to understand much of the biology discussed in the book. (freecomputerbooks.com)
  • The course covers essential aspects of biochemistry, cell biology, and molecular biology. (jhu.edu)
  • Several courses in the Bioinformatics track of Computer Science require background in Molecular Biology. (jhu.edu)
  • For example, they handle licensing for commonly used scientific software, such as Matlab and EndNote, that Molecular Biology provides to our labs. (harvard.edu)
  • A set of the Computer Services team also provides on-demand support for administrative functions of the Molecular Biology faculty and staff. (harvard.edu)
  • Recent work in the Journal of Molecular Biology has described how advances in technology and biology could produce a three-dimensional computer model of cells, something that has so far been elusive. (labroots.com)
  • Cells are the foundation of life,' explained one co-author of the paper, Ilya Vakser, a Professor of Computational Biology and Molecular Biosciences and Director of the Center for Computational Biology at the University of Kansas. (labroots.com)
  • Taken together, the methods can enable a better 'understanding of life at the molecular level and lead to important applications to biology and medicine. (labroots.com)
  • One of the most exciting and influential areas of science today, biochemistry and molecular biology (BCMB) exists at the intersection of biology and chemistry. (clarku.edu)
  • Our biochemistry and molecular biology major puts you on the fast track to discovery, allowing you to engage in research as early as your first year, co-author research papers with faculty members or graduate students, and present those papers at professional conferences. (clarku.edu)
  • Why Study Biochemistry and Molecular Biology at Clark? (clarku.edu)
  • The biochemistry and molecular biology major is highly structured and requires a solid grounding in biology and chemistry, as well as courses in physics and calculus. (clarku.edu)
  • During your junior year, you might be accepted into the biochemistry and molecular biology honors program. (clarku.edu)
  • The new era of large-scale experimental methods in molecular biology has transformed it into an information-based science, making bioinformatics an integral part of genomic research. (princeton.edu)
  • My group develops algorithms for a diverse set of problems in computational molecular biology. (princeton.edu)
  • Molecular computing is also inspired from biology. (chembites.org)
  • Nevertheless, it is still a very active research area mainly due to the continuous advances in computational biology and computer graphics techniques. (elsevier.com)
  • BCHM 218 is a foundational course to the study of molecular biology, focusing on the structural and functional properties and relationships of DNA, RNA and proteins, particularly the processes required to reliably pass genetic information from DNA to RNA to protein, and from one generation to the next. (queensu.ca)
  • The Department of Cell Biology and Anatomy, Faculty of Medicine and Oral Health Sciences, offers graduate programs leading to the MSc and PhD degrees in cell and molecular biology. (gradschools.com)
  • The concept Molecular biology -- Computer simulation represents the subject, aboutness, idea or notion of resources found in University of Liverpool . (liverpool.ac.uk)
  • The inspiration for molecular nanotechnology comes from Richard P. Feynman's 1959 visionary talk at Caltech in which he said, "The problems of chemistry and biology can be greatly helped if our ability to see what we are doing, and to do things on an atomic level, is ultimately developed---a development which I think cannot be avoided. (bibliotecapleyades.net)
  • Molecular Biology is a subject which you will study as a part of your bachelor programme at Roskilde University. (ruc.dk)
  • Molecular Biology is the part of biology that concerns itself with macromolecules' properties and interactions, and examines the function of genes and the function of the proteins that are formed. (ruc.dk)
  • is interested in the application of artificial intelligence to problems in computational molecular biology. (cmu.edu)
  • I have to confess that this is not my field of expertise beyond a synthetic biology course, however, coming from a computer science background, most topics were somewhat familiar. (medium.com)
  • This booklet presents an advent, appropriate for complex undergraduates and starting graduate scholars, to 2 vital elements of molecular biology and biophysics: machine simulation and knowledge research. (cinemarden.com.br)
  • The transparent and concise writing variety is usually beautiful to the chemist who desires to study extra approximately molecular biology. (cinemarden.com.br)
  • the emerging field of Systems Biology, where many forms of data are used to create a computer-based model of a complex biological system. (computer.org)
  • This groundbreaking approach to molecular simulations could have profound implications not just for quantum chemistry, but also for a range of fields from cryptography to materials science. (redorbit.com)
  • While modern supercomputers can perform approximate simulations of simple molecular systems, increasing the size of the system results in an exponential increase in computation time. (redorbit.com)
  • While a number of other physical systems could serve as a computer framework, Aspuru-Guzik's colleagues in Australia used the information encoded in two entangled photons to conduct their hydrogen molecule simulations. (redorbit.com)
  • As all computer simulations are idealized representations of the real world, a certain purity of assumption places limitations on the power of the software to mimic reality. (scienceteacherprogram.org)
  • 6. I can make this research more concrete for my students by showing them images and videos of the molecules I studied, and leading them in basic molecular simulations of their own. (scienceteacherprogram.org)
  • Biosym has been using existing but less sophisticated computer-generated simulations to develop its own line of molecular modeling programs, Klipstein said. (latimes.com)
  • CCG is a leading developer and provider of Molecular Modeling, Simulations and Machine Learning software to Pharmaceutical and Biotechnology companies as well as Academic institutions throughout the world. (chemcomp.com)
  • The University of Chicago will receive $10 million in computer software from San Diego-based BIOSYM/Molecular Simulations under a cooperative research and development agreement. (uchicago.edu)
  • University scientists will use the software for computer-aided molecular modeling and simulation, and they will work with BIOSYM/Molecular Simulations employees to explore ways in which these tools can be used to enhance research and development, technology infrastructure, curriculum design, networking, training and new forms of imaging, including virtual reality. (uchicago.edu)
  • This collaborative agreement will give faculty members at Chicago access to a broad range of new information technology tools, said Adam Bernstein, Academic Manager for BIOSYM/Molecular Simulations. (uchicago.edu)
  • The BIOSYM/Molecular Simulations software will give the researchers the tools they need to analyze and work with the important data that will come from the APS. (uchicago.edu)
  • BIOSYM/Molecular Simulations develops and markets Computer-Aided Molecular Science (CAMS) applications software to researchers in academia, industry and government laboratories worldwide. (uchicago.edu)
  • BIOSYM/Molecular Simulations is headquartered in San Diego and has 13 field offices in North America, Europe and Asia. (uchicago.edu)
  • Computer simulations point to key molecular basis of cysti. (bio-medicine.org)
  • Using molecular dynamics simulations, the researchers performed extensive simulations of how normal and mutant NBD1 folded. (bio-medicine.org)
  • Computer simulations approximate our understanding of natural phenomena. (bio-medicine.org)
  • They will not only introduce students to the subject, but also enable them to conduct their own computer simulations. (cambridge.org)
  • By taking as input the structure ensemble of a given protein, which may be composed of existing experimental structures and/or conformations generated from molecular dynamics simulations, the proposed method carries out a spatial mapping of the protein?s inner space at each conformation in the ensemble. (iastate.edu)
  • A series of classical MD computer simulations were performed for [PtCl6]2‒ in these equimolar binary solvent mixtures, using a recently revised force field developed by Naidoo et al. (sun.ac.za)
  • Simulations were repeated with ionic charges scaled according to the recently developed Molecular Dynamics in Electronic Continuum (MDEC) theory, which is intended to account for the dielectric screening of charges in condensed phases. (sun.ac.za)
  • Here, we investigated the molecular interplay of MMP2 with different GAG (chondroitin sulfate, hyaluronan (HA), sulfated hyaluronan (SH) and heparin (HE)) and the impact of GAG on MMP2/TIMP3 complex formation using in vitro -experiments with human bone marrow stromal cells, in silico docking and molecular dynamics simulations. (nature.com)
  • Molecular dynamics computer simulations have been used to probe the role of the projectile composition on the emission efficiency and the sample damage. (edu.pl)
  • The specific goal of the computational part is to carry out molecular dynamics simulations of mixtures of proteins and analyze their interactions. (msu.edu)
  • In the present simulations, we adopt simple interatomic force laws because we want to investigate the generic features of a particular many-body problem common to a large class of real physical systems and not governed by the particular complexities of a unique molecular interaction. (pnas.org)
  • Methods of computer simulations in free energy calculations are briefly discussed. (chemicke-listy.cz)
  • Rosanov and his group began their work with computer simulations, suggesting that it was theoretically possible to produce a stable soliton in a wide-aperture laser if it was stabilised by external radiation. (vixra.org)
  • Californian and Israeli researchers have created a biological computer - a machine made from biological molecules - that successfully decoded two images stored and encrypted within DNA. (extremetech.com)
  • Ultimately, the same quantum computer that could transform Internet cryptography could also calculate the lowest energy conformations of molecules as complex as cholesterol. (redorbit.com)
  • While other molecules had been used as computational substrates, molecular biologist Leonard Adelman gained considerable notoriety by demonstrating how a classic mathematical problem could be formulated as a bonding problem for a small set of DNA oligomers. (jrank.org)
  • The Journal of Computer-Aided Molecular Design provides a form for disseminating information on both the theory and the application of computer-based methods in the analysis and design of molecules. (springer.com)
  • Why: To foster student appreciation for-and understanding of-the way scientists use computers to model molecules. (scienceteacherprogram.org)
  • The results of light induced internal molecular motions in azo-dyes molecules have been used for the design and B3PW91-Time Dependent (TD)/6-311G** calculations of light driven OR logically controlled molecular machines composed from photoactive organic molecules such as electron donor: dithieno[3,2-b:2',3'-d]thiophene and ferocene (C 10 H 10 Fe) and electron accepting and moving part of DO3 molecule. (foresight.org)
  • In an article published in Molecules, Lin presented a novel approach for assessing molecular diversity based on Shannon information theory. (igi-global.com)
  • Molecular dynamics simulation is akin to a virtual experiment wherein atoms and molecules are allowed to evolve according to known physical laws. (bio-medicine.org)
  • And in the late 1990s, researchers successfully created a set of DNA molecules - a DNA computer - able to solve simple mathematical problems . (plausiblefutures.com)
  • The calculation of the standard enthalpies of vaporization, sublimation and solvation of organic molecules is presented using a common computer algorithm on the basis of a group-additivity method. (mdpi.com)
  • The computational framework developed in this project will provide the scientific community with an invaluable tool that can be adapted to study the molecular control mechanisms of many other bio-molecules. (iastate.edu)
  • Molecular electronics, which uses molecules as building blocks for the fabrication of electronic components, was seen as the ultimate solution to the miniaturization challenge. (phys.org)
  • The only known molecules that can be pre-designed to self-assemble into complex miniature circuits, which could in turn be used in computers, are DNA molecules. (phys.org)
  • Now, an international group led by Prof. Danny Porath, the Etta and Paul Schankerman Professor in Molecular Biomedicine at the Hebrew University of Jerusalem, reports reproducible and quantitative measurements of electricity flow through long molecules made of four DNA strands, signaling a significant breakthrough towards the development of DNA-based electrical circuits . (phys.org)
  • In molecular machines, this limitation can be overcome due to molecules having more than two states to store information within. (chembites.org)
  • This position is part of a larger multi-institution collaborative project aimed at simulating strongly correlated molecules on small, high-fidelity quantum computers, designed and fabricated by our collaborators. (physicstoday.org)
  • The emerging field of molecular electronics -- using nanoscale molecules as key components in computers and other electronic devices -- is in excellent health and has a bright future, conclude UCLA, Caltech and University of California, Santa Barbara, chemists who assess the field in the Dec. 17 issue of the journal Science . (phys.org)
  • Dreams I was having less than a decade ago are becoming a reality in our labs," said Stoddart, whose areas of expertise include nanoelectronics, mechanically interlocked molecules, molecular machines, molecular nanotechnology, molecular self-assembly processes and molecular recognition, among many other fields of chemistry. (phys.org)
  • Although many classes of molecules can be used for molecular electronics, only a small percentage of these have been assessed so far," Flood said. (phys.org)
  • Journal of Computer-Aided Molecular Design - incl. (springer.com)
  • This book brings together central themes covering proteins of the immune system with special emphasis on the protein chemistry of the system, The understanding, at the molecular level, of the interactions between innate and adaptive arms of the immune system is currently a hot topic, particularly to those interested in immunology - especially susceptibility to infectious diseases. (worldcat.org)
  • The objective of this proposal is to map out the ligand migration channel networks inside proteins and determine the molecular control mechanisms by which these channels are regulated dynamically. (iastate.edu)
  • As a graduate student with Dr. Michael Jordan, collaborating with Dr. Steven Brenner, I created a statistical methodology, SIFTER (Statistical Inference of Function Through Evolutionary Relationships), to capture how protein molecular function evolves within a phylogeny in order to accurately predict function for unannotated proteins, improving over existing methods that use pairwise sequence comparisons. (princeton.edu)
  • Only SH supported the alignment of both proteins in fibrillar-like structures, which, based on our molecular models, would be due to a stabilization of the interactions between MMP2-hemopexin domain and TIMP3-C-terminal tail. (nature.com)
  • Computer Atlas of Surface Topography of Proteins (CASTp) aims to provide comprehensive and detailed quantitative characterization of topographic features of protein, is now updated to version 3.0. (wikipedia.org)
  • Contemporary Computer-Assisted Approaches to Molecular Structure Elucidation describes the principles on which these expert systems for spectroscopic structure elucidation are based and concisely explains the algorithmic concepts behind the programs. (rsc.org)
  • A Contemporary Computer Assisted Approaches to Molecular Structure for Cooperative Learning. (innovations-atelier.de)
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  • Contributions on computer-aided molecular modeling studies in pharmaceutical, polymer, materials and surface sciences, as well as other molecular-based disciplines, are particularly welcome. (springer.com)
  • My research was driven by the theory that computer-based molecular modeling is useful in understanding the surface morphology, electrostatic potential, and reaction mechanisms of biological macromolecules. (scienceteacherprogram.org)
  • 3. In exploring this question, I conducted extensive molecular modeling on a Silicon Graphics Indigo 2, using GRASP software. (scienceteacherprogram.org)
  • D. Gautheret, F. Major, and R. Cedergren , Computer Modeling and Display of RNA Secondary and Tertiary Structures. (elsevier.com)
  • Biosym is a small, privately held San Diego-based company that develops molecular computer modeling tools for the chemical research industry. (latimes.com)
  • The companies already had initiated their own molecular modeling programs, Klipstein said, but joined the San Diego consortium to speed basic research into the field, which is "crucial to the growth of the chemical and pharmaceutical industries. (latimes.com)
  • Biosym plans to add the new computer programs generated by the consortium to its line of molecular computer modeling tools. (latimes.com)
  • 2. Interactive Modeling Computer-assisted molecular design (CAMD) was introduced into chemistry only a relatively short time ago, whereas computer-assisted design in engineering (CAD) has been well established for several years. (docme.ru)
  • Recently, there has been tremendous progress in biomolecular modeling and advances at understanding life at the molecular level. (labroots.com)
  • Paving the way for a new generation of DNA-based computer circuits: Prof. Danny Porath, of the Hebrew University's Institute of Chemistry and Center for Nanoscience and Nanotechnology. (phys.org)
  • In an article, `Natural strategies for the molecular engineer`, published today in the Institute of Physics` journal, Nanotechnology, Philip Ball, consultant editor of Nature, discusses how molecular engineers can learn from the designs and tricks employed by nature - in processes ranging from catalysis to mechanical motion, energy conversion, information processing and materials synthesis. (innovations-report.com)
  • This document surveys a number of future molecular nanotechnology capabilities of aerospace interest. (bibliotecapleyades.net)
  • If advanced molecular nanotechnology can be developed, almost all of NASA's endeavors will be radically improved. (bibliotecapleyades.net)
  • In particular, a sufficiently advanced molecular nanotechnology can arguably bring large scale space colonization within our grasp. (bibliotecapleyades.net)
  • This document describes potential aerospace applications of molecular nanotechnology, defined as the thorough three-dimensional structural control of materials, processes and devices at the atomic scale. (bibliotecapleyades.net)
  • Drexler 92a], an expanded version of Drexler's MIT Ph.D. thesis, examines one vision of molecular nanotechnology in considerable technical detail. (bibliotecapleyades.net)
  • Another approach to nanotechnology is supramolecular self-assembly, where molecular systems are designed to attract each other in a particular orientation to form larger systems. (bibliotecapleyades.net)
  • Biological systems can do most of what molecular nanotechnology strives to accomplish -- atomically precise products, active materials, reproduction, etc. (bibliotecapleyades.net)
  • However, biological systems are extremely complex and molecular nanotechnology seeks simpler systems to understand, control and manufacture. (bibliotecapleyades.net)
  • In the second, we investigate some potential molecular nanotechnology payoffs for each area identified in NASA's strategic plan. (bibliotecapleyades.net)
  • We use the molecular dynamics computer simulation technique to study the behavior of electron plasmas in the presence of highly charged ions and strong magnetic fields. (cnki.net)
  • We performed a molecular dynamics computer simulation to determine if the PTC mechanism is responsible for the observed behavior of Δζ. (cnki.net)
  • 5. Molecular Beam Epitaxial III-V Compounds: Dopant Incorporation, Characteristics and Behavior. (exlibris.ch)
  • 2016 - Lulu Qian, CalTech: "A Future Written by Molecular Programmers" , Assistant Professor of Bioengineering, is interested in engineering molecular systems with intelligent behavior: specifically, exploring the principles of molecular programs in nature with the end goal of recreating synthetic molecular programs that approach the complexity and sophistication of life itself. (medium.com)
  • The current approach uses the algorithms which are used to solve the Molecular Distance Geometry Problem in order to find the coordinates of the atoms in the peptide plane of given protein. (uwindsor.ca)
  • We are particularly interested in predicting specificity in protein interactions and uncovering how molecular interactions and functions vary across context, organisms and individuals. (princeton.edu)
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  • Computer-Assisted Structure Elucidation (CASE) systems are a combination of software algorithms and tools to support and enable chemists and spectroscopists engaged in the process of molecular structure elucidation via the analysis of spectroscopic data. (rsc.org)
  • This one-day mini-workshop aims to bring together researchers working on two-temperature molecular dynamics (2T-MD), an atomistic modelling technique that incorporates electronic energy effects, to discuss developments in its theory, algorithms and applications. (ccp5.ac.uk)
  • The Computing Science Department offers programs leading to the degrees of Master of Science and Doctor of Philosophy in a number of fields, including artificial intelligence, database management, design and analysis of computer algorithms, computer gra. (gradschools.com)
  • By adding bits to each encoded unit, redundancy allows the computer to both detect errors in coded data and correct them based on mathematical algorithms. (wikipedia.org)
  • The combined use of computer graphics and theoretical chemistry is opening u p new perspectives in molecular research. (docme.ru)
  • 1. Introduction Computer-assisted molecular design is a new approach to molecular research using methods from theoretical chemistry. (docme.ru)
  • Part I: Computers for Chemistry: Progress towards the design of accurate computational tools to predict the selectivity of chemical reactions. (columbia.edu)
  • Part II: Chemistry for Computers: From novel antiaromatic and pi-pi-stacked molecular wires to highly conducting link groups with direct Au-C bonds. (columbia.edu)
  • This research will be carried out in collaboration with a senior researcher in the Feig laboratory and requires a background in biochemistry, physical chemistry or physics, and basic computer skills. (msu.edu)
  • Biological Sciences, Chemistry and Computer Science . (cmu.edu)
  • Molecular electronics is in its infancy, and its adolescence and adulthood will be very exciting as we push toward the promise of molecular electronics: smaller, more versatile and more efficient," said Amar Flood, a UCLA researcher in Fraser Stoddart's supramolecular chemistry group, and lead author of the Science paper. (phys.org)
  • The department's Computer Services team includes a group of specialists who focus on the support of scientific computing for bioinformatics, high-throughput microscopy, and other data intensive applications. (harvard.edu)
  • Students can apply after completion of their third year in 6-7, provided they have taken 96 units in the major and at least one foundational subject in computer science and one foundational subject in biological science. (mit.edu)
  • Dr. Lawrence Hunter is the Director of the Computational Bioscience Program and of the Center for Computational Pharmacology at the University of Colorado School of Medicine, and a Professor in the departments of Pharmacology, Computer Science (Boulder), and Preventive Medicine and Biometrics. (freecomputerbooks.com)
  • The is is a joint laboratory with the Department of Computer Science and the Lewis-Sigler Institute for Integrative Genomics. (princeton.edu)
  • The Princeton S* Network Systems (SNS) group within Princeton's Computer Science Department. (princeton.edu)
  • Other partners include the American Association of Physicists in Medicine (AAPM), American Association of Physics Teachers (AAPT), American Physical Society (APS Physics), AVS Science and Technology, IEEE Computer Society, and the Society of Physics Students (SPS) and Sigma Pi Sigma. (physicstoday.org)
  • 07/25/2012 - Computer Science professor Chandrajit Bajaj uses software to fight disease. (utexas.edu)
  • 06/24/2012 - The Department of Computer Science will decrease the number of required classes needed to obtain a degree from the department, a move some faculty hope will allow students to specialize in their interests and experience more while attending school. (utexas.edu)
  • The most popular Perl programming books are often too theoretical and too focused on computer science for a non-programming biologist who needs to solve very specific problems. (oreilly.com)
  • In order to maximize the efficiency of making new drugs or plastics, scientists have created a tiny machine that acts as something of an assembly line on the molecular level. (extremetech.com)
  • In an important first for a promising new technology, scientists have used a quantum computer to calculate the precise energy of molecular hydrogen. (redorbit.com)
  • where scientists can use computers to experiment with different variations and combinations," said Klipstein. (latimes.com)
  • Yet while scientists made great strides in reducing of the size of individual computer components through microelectronics, they have been less successful at reducing the distance between transistors, the main element of our computers. (phys.org)
  • 07/23/2012 - Assistant Professor Brent Waters has earned a Presidential Early Career Award for Scientists and Engineers (PECASE) for his research in cryptography and computer security from President Barack Obama. (utexas.edu)
  • Campers work together on programming language labs and logic games, see surgical robots in action, meet professional computer scientists, get career mentoring, play games, enjoy campus life and get a taste of what it's like to have a fascinating, well-paying job. (utexas.edu)
  • 06/26/2012 - UT Austin Villa, a team of robots led by University of Texas computer scientists, took home two 2012 Robot Soccer World Cup division championships during the RoboCup 2012 in Mexico City this month. (utexas.edu)
  • Over the past decade, scientists around the world have taken a few model molecular systems, including bistable catenanes and rotaxanes, and have addressed many of the fundamental scientific principles related to harnessing their potential in electronic circuits. (phys.org)
  • This is the first time that a quantum computer has been built to provide these precise calculations. (redorbit.com)
  • Aspuru-Guzik's team coordinated experimental design and performed key calculations, while his partners in Australia assembled the physical "computer" and ran the experiments. (redorbit.com)
  • Researchers have developed a molecular computer, which uses enzymes to perform calculations from within the human body and to monitor the release of drugs. (medindia.net)
  • Molecular computers have the potential to surpass the speed and power of existing silicon computers because they can perform many calculations simultaneously and pack a vast number of components into a tiny space. (medindia.net)
  • There are performing Nuclear Magnetic Resonance (NMR) calculations of series Cu, Fe or Co biliverdin derivatives and other paramagnetically 1H shifted derivatives in order to find quantum computer elements with broad NMR spectra for good Quantum Bits resolution. (foresight.org)
  • Future models of the living computer, made from the DNA-like molecule RNA , could be used to run calculations in vivo - that is, inside human cells - to release drugs or prime the immune system at the first hint of illness. (plausiblefutures.com)
  • The workshop program combines morning lectures, which elucidate the theoretical concepts and numerical procedures, with practical sessions in the computer laboratory where the basics of the calculations explained and demonstrated and simple research problem tackled. (ucla.edu)
  • In the present review, we therefore try to outline the spectrum of theoretical, molecular research by presenting a representative selection of the large variety of methods used and their possibilities. (docme.ru)
  • The theoretical download Computer Aided Molecular people helped their invalid and European beam users to be their design to the firm, not putting Institutions that sent in the North, in the capital combinations, and in the movement of the ja itself. (atlantaflyfishingschool.com)
  • Brookhaven researchers Sergei Maslov (left) and Alexi Tkachenko developed a theoretical model to explain molecular self-replication. (newswise.com)
  • The default illumination mode for the Intel Play QX3 Computer Microscope is either transmitted or reflected brightfield. (fsu.edu)
  • In each thematic issue invited experts provide recent developments, highlight opportunities and indicate current limitations concerning the use of computers in drug discovery and design. (springer.com)
  • Eight leading drug, chemical and computer companies have formed a San Diego-based consortium to conduct basic research into computer-aided molecular design programs. (latimes.com)
  • Further design of series molecular implementations of two variable logic functions: AND (NAND), OR (NOR), etc. is based on quantum chemical ab initio HF/6-311G** geometry optimization procedure which allow to predict stability of our newly designed logical gates based on C 60 substituted derivatives CH 2 CH 2 NHC 60 and CH 2 C 60 . (foresight.org)
  • First principles quantum chemical B3PW91\6-311G** design of quantum computers elements generating from one to six qubits are started basing on series Cu, Fe or Co biliverdin derivatives replacing hydrogen atoms by Cl, F or Br atoms. (foresight.org)
  • Agarwal, Rahul, Ashutosh Singh and Subhabrata Sen. "Role of Molecular Docking in Computer-Aided Drug Design and Development. (igi-global.com)
  • Applied Case Studies and Solutions in Molecular Docking-Based Drug Design. (igi-global.com)
  • More importantly, the molecular details of aberrant NBD1 folding provides guidance for the design of small molecule drugs to correct the most prevalent and pathogenic mutation in CFTR. (bio-medicine.org)
  • Computer-Assisted Molecular Design (CAMD)ЧAn Overview. (docme.ru)
  • Computer-Assisted Molecular Design (CAMD)- An Overview By Horst Friihbeis," Robert Klein, and Holger Wallmeier Dedicated to Professor Heinz Harnisch on the occasion ofhis 60th birthday A new instrument, long established as C A D in engineering, is beginning to make its presence felt in chemical research laboratories: Computer-Assisted Molecular Design (CAMD). (docme.ru)
  • The interest of industrial research in computer-assisted molecular design stems from the desire to make the search for new drugs and plant protection agents more efficient. (docme.ru)
  • We regard computer-assisted molecular design as a new additional tool for research-combination with experiment still remains an essential precondition for successful molecular design. (docme.ru)
  • One of the reasons for this is that interactive work with three-dimensional structures-a typical operation in molecular design-requires highly developed computer graphics systems, which have become available only in the last few years. (docme.ru)
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  • Therefore, while part I of this dissertation focuses on new structure-based computational methodologies to predict selectivities of organic and enzymatic reactions, part II is concerned with the design, the synthesis and the electrical properties of novel, single molecular wires. (columbia.edu)
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  • A methodology is presented to solve a computer-aided molecular design (CAMD) and process design model problems under consideration of fluid property uncertainty. (dtu.dk)
  • The Computer-Aided Molecular Design Laboratory of Yuan-Ping Pang, Ph.D., is located on the 12th floor of the Stabile Building on the Mayo Clinic campus in Rochester, Minnesota. (mayo.edu)
  • These defects have garnered great interest over the past decade, providing a test-bed system for developing semiconductor quantum bits as well as nanoscale sensors," said team leader David Awschalom, the Liew Family Professor of Molecular Engineering at UChicago. (ecnmag.com)
  • ENGLISH ABSTRACT: A combined 195Pt NMR spectroscopy and Molecular Dynamics (MD) computer simulation study of the solvation of the octahedral Pt(IV) complex [PtCl6]2‒ in binary mixtures of water and the fully water-miscible organic solvents methanol, 2-methoxyethanol and 1,2-dimethoxyethane has been carried out. (sun.ac.za)
  • A lot of research is going on to finally combine the abstract idea of Turing machines and molecular machines to build "Molecular Turing Machines. (chembites.org)
  • Nature has been manipulating structures on the atomic and molecular scale for millions of years, in comparison humans have only been developing these techniques over the last few decades. (innovations-report.com)
  • Molecular engineering builds structures and devices at the smallest scales imaginable, aiming to make better materials, new types of information technologies, biomedical devices and much more. (innovations-report.com)
  • Quantum computing has been heralded for its potential to solve certain types of problems that are impossible for conventional computers to crack. (redorbit.com)
  • There are still outstanding problems to solve in computer-aided diagnosis (CAD), such as the number of false alarms. (innovations-report.com)
  • Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can't manage. (innovations-report.com)
  • Molecular visualization is one of the oldest branches of scientific visualization, which has been developing for over 50 years. (elsevier.com)
  • We invite original research, system, and survey papers that summarize and expand the state of the art in visualization and computer graphics with a strong focus on applications to molecular data. (elsevier.com)
  • This online tool also supports PyMOL and UCSF Chimera plugin for molecular visualization. (wikipedia.org)
  • This e-book describes a strong and potent software for the molecular biologist researcher. (cinemarden.com.br)
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  • According to Prof. Porath, "This research paves the way for implementing DNA-based programmable circuits for molecular electronics , which could lead to a new generation of computer circuits that can be more sophisticated, cheaper and simpler to make. (phys.org)
  • Drexler 92a] proposes the development of programmable molecular assembler/replicators. (bibliotecapleyades.net)
  • To this end, she works on designing and constructing nucleic-acid systems from scratch that exhibit programmable behaviors from the basic level - such as recognizing molecular events from the environment, processing information, making decisions, and taking actions - to the advanced level, such as learning and evolving. (medium.com)
  • Further development of molecular machines are performing using B3PW91\6-311G** geometry optimization of larger molecular robots possessing efficient fluorescence (Fluorescein-DO3) and anti-oxidant biological activity (Biliverdin CuOEB-DO3) and searching the charge transfer of these molecular devices in different excited states using B3PW91\6-311G**-TD. (foresight.org)
  • Calculation results allow to predict molecular devices with stable electronic structure and choose devices with optimal features of fluorescencing and anti-oxidant activity that makes able to use them in sensitive nano-structured organic and biological sensors. (foresight.org)
  • The real strength of these molecular devices is in working and computing inside biological systems , where DNA has evolved to be at home. (plausiblefutures.com)
  • Computer speciation models of antimony in aqueous, multicomponent solutions of environmental and biological interest have been developed. (edu.au)
  • Press strong download molecular evolution: Nine labors in ability. (ever4hotels.com)
  • If it is computationally too complex to simulate a quantum system using a classical computer," he says, "why not simulate quantum systems with another quantum system? (redorbit.com)
  • The team figured out how to utilize the molecular machinery of living systems to power an integrated circuit. (inhabitat.com)
  • The authors overall goal is writing this book is to produce the 'must read' definitive text that will represent the results of decades of work to develop computer-assisted structure elucidation software systems. (rsc.org)
  • In developing the model of the DNA double helix, Watson and Crick[*]opened up a new dimension in the understanding of specificity.131 Concomitant with the increasing interest in large systems more and more detailed problems are being encountered, and there is a growing tendency to transfer molecular models from the chemist's desk to the computer. (docme.ru)
  • Our expressions for the nonlinear time-dependent response are tested against nonequilibrium molecular dynamics computer simulation of two simple nonautonomous systems. (cnki.net)
  • These systems can store, modify and customize information at molecular level and provide more levels of information than just the binary codes 0 and 1. (chembites.org)
  • The focus of this position is to implement new electronic structure methods designed for efficient mapping of molecular systems to quantum hardware. (physicstoday.org)
  • Replication is one approach to building large systems, such as human rated launch vehicles, from molecular machines manipulating matter one or a few atoms at a time. (bibliotecapleyades.net)
  • CollabRx, Inc., a data analytics company focused on genomics, bridges this knowledge gap using cloud-based expert systems to inform healthcare decision-making by aggregating and contextualizing the world's knowledge on molecular medicine with specific insights from the nation's top clinical experts. (thestreet.com)
  • Researchers from the University of North Carolina at Chapel Hill have identified a key molecular mechanism that may account for the development of cystic fibrosis, which about 1 in 3000 children are born with in the US every year. (bio-medicine.org)
  • Using computers, this virtual experiment allows researchers to view how atoms actually move. (bio-medicine.org)
  • This code is used by researchers at Virginia Tech to investigate phenomena underlying the emerging eld of molecular electronics. (vt.edu)
  • Now researchers have shrunk such a facility to the size of a computer chip. (vixra.org)
  • The consortium will use powerful computers to formulate mathematical models simulating chemical interactions that otherwise would have to be performed in time-consuming laboratory experiments, Klipstein said Monday. (latimes.com)
  • Computers whose input, output and state transitions are carried out by biochemical interactions and reactions. (uchicago.edu)
  • Exploring the cellular and molecular building blocks of living organisms is a fascinating - and humbling - experience, as you uncover the very conditions and interactions that make life (and you) possible. (clarku.edu)
  • He headed the Laboratory of Molecular Spectroscopy at the All-Russian Institute for Organic Synthesis in Moscow (1981-2001). (rsc.org)
  • Since one sequence of qubits can represent many different numbers, a quantum computer would make far fewer computations than a conventional one in solving some problems. (redorbit.com)
  • The central processing unit (CPU) of a computer is what manipulates data by performing computations. (wikipedia.org)
  • Today, extremely precise atomic and molecular manipulation is common in many laboratories around the world and our abilities are rapidly approaching Feynman's dream. (bibliotecapleyades.net)
  • CAMS software combines scientific principles with advanced computer-based techniques to reduce the time needed to discover new chemical compounds in the life and materials sciences. (uchicago.edu)
  • These single molecule technologies described in part II are likely to contribute to more powerful computer chips in the future, which will in turn lead to faster and more accurate computational predictions for chemical problems. (columbia.edu)
  • Computers & Chemical Engineering , 122 , 247-257. (dtu.dk)
  • Molecular computing: paths to chemical Turing machine. (chembites.org)
  • The University will be a center for molecular research next year when the Advanced Photon Source (APS) at Argonne National Laboratory is fully activated. (uchicago.edu)
  • We describe the second of two large-scale atomic simulation projects on materials failure performed on the 12-teraflop ASCI (Accelerated Strategic Computing Initiative) White computer at the Lawrence Livermore National Laboratory. (pnas.org)
  • I thought you might be interested in this item at http://www.worldcat.org/oclc/873640029 Title: Replication competent viruses for cancer therapy : summarizes the molecular principles of modern viral therapy for cancer Author: Pablo Hernáiz Driever Publisher: Basel : Karger, 2001. (worldcat.org)
  • This book is the first to summarize the molecular principles of modern viral therapy for cancer. (worldcat.org)
  • It's hard because we're just beginning to understand the principal mechanisms of life at the molecular level -- it looks extremely complicated but doable, so we're moving very fast -- not only in our ability to understand how it works at the molecular level but to model it. (labroots.com)
  • In addition, the chromosome breakpoints and joining regions in an APL case with t(11;17)(q23;q21) were cloned and analyzed to explore possible molecular mechanisms of aberrant gene rearrangement in APL. (pnas.org)
  • This research increases our general knowledge of these processes and their molecular mechanisms, which is also of major importance for our understanding of a number of diseases. (ruc.dk)
  • Itamar Willner, who built the computer with colleagues at the Hebrew University of Jerusalem in Israel, said the enzyme-powered computers could have significant pharmaceutical and biomedical applications and could, in the future, be implanted into humans. (medindia.net)
  • Understanding molecular etiology of the disease is a key step to developing pharmaceutical strategies to fight this disease, Dokholyan said. (bio-medicine.org)
  • DNA shares its essential features with computers - it stores, processes and communicates information. (plausiblefutures.com)
  • The team's method specifically accounts for the expression of enzymes, which are the molecular machines responsible for the biochemical processes of life. (healthcanal.com)
  • The UCLA/Caltech team has verified that bistable catenanes and rotaxanes work as molecular switches that can be turned on and off when they are attached to surfaces and when they are buried in polymer blends with the consistency of a rubber tire. (phys.org)
  • At the beginning, the first successful single molecule conductance measurements ever on partially antiaromatic molecular wires are described. (columbia.edu)
  • Complexity, Emergence and Molecular Diversity via Information Theory. (igi-global.com)
  • Thus, we must thoroughly reflect upon a responsible approach towards the quickly growing spectrum of diagnostic and therapeutic options and which roles computer support could play," said Hahn. (innovations-report.com)
  • Preliminary studies have shown that the abilities of computers using pattern recognition often match those of humans, or, as in the case of suspected microcalcification in mammography, exceed them. (innovations-report.com)
  • Computer applications, launch vehicle improvements, and active materials appear to be of particular interest. (bibliotecapleyades.net)
  • The first applications are likely to involve hybrid devices that combine molecular electronics with existing technologies, such as silicon, said Stoddart, director of the California NanoSystems Institute (CNSI), who holds UCLA's Fred Kavli Chair in NanoSystems Sciences. (phys.org)
  • Ultimately, we would like to have control over device properties through molecular synthesis. (phys.org)
  • Research will be conducted on computers at Biosym, at member companies and at the Minneapolis headquarters of Cray Research, which builds supercomputers--ones that can process millions of bits of information quickly. (latimes.com)
  • A new nonequilibrium molecular dynamics computer simulation method has been developed for the study of rapid interface kinetics. (cnki.net)
  • For several topics concerning the crystallization control of calcium carbonate, which is a representative mineral in biomineralization, we elucidated the mechanism of the crystallization control by additives using a computer simulation method at the molecular scale. (nii.ac.jp)
  • When a quantum computer is put to work on a problem, it considers all possible answers by simultaneously arranging its qubits into every combination of "zeroes" and "ones. (redorbit.com)
  • But how do you test a quantum computer to. (innovations-report.com)
  • Much like conventional computers use the charge state of electrons to constitute bits of information, a quantum computer would use the spin state of a single electron as its quantum bit, or qubit. (ecnmag.com)
  • 3. The Application of Thermodynamics to Molecular Beam Epitaxy. (exlibris.ch)
  • A program of interest to surface chemists has been developed for use on NRL's Control Data Corporation 3800 computer. (dtic.mil)
  • The program reads film pressure, surface potential, and molecular area data. (dtic.mil)
  • 3.3 Output CASTp identifies all surface pockets, interior cavities and cross channels, provides detailed delineation of all atoms participating in their formation, including the area and volume of pocket or void as well as measurement of numbers of mouth opening of a particular pocket ID by solvent accessible surface model (Richards' surface) and by molecular surface model (Connolly surface), all calculated analytically. (wikipedia.org)
  • Therefore, we are happy to announce an open call for submissions to the Computers and Graphics Journal (C&G) Special Section on Molecular Graphics and Visual Analysis of Molecular Data. (elsevier.com)
  • dry neurons: An Contemporary Computer Assisted to Coding and Analysis. (innovations-atelier.de)
  • Molecular analysis, including genetic sequencing, is increasingly becoming an important part of the clinical management of cancer patients," said James Karis, Co-CEO of CollabRx. (thestreet.com)
  • The NATO Advanced Study Institute on "Molecular Beam Epitaxy (MBE) and Heterostructures" was held at the Ettore Majorana Center for Scientific Culture, Erice, Italy, on March 7-19, 1983, the second course of the International School of Solid-State Device Re search. (exlibris.ch)