Continuous electrocardiographic recording during exercise in young male diabetics. A computer study. (1/11)

Forty selected young patients with diabetes of medium to long duration and 26 control subjects without clinical evidence of ischaemic heart disease were studied using a new and sensitive technique of electrocardiographic recording during exercise with continuous computation of the time course of the ST-T segment changes to detect possible early ST depression indicative of ischaemia. Although no such evidence was found, significant differences in the diabetics were observed in the heart rate and ST-T segment, the latter changes having not been previously reported but which may be attributed to ischaemia or alternatively to autonomic neuropathy in the "presymptomatic" phase.  (+info)

Stable isotope ratiometer-multiple ion detector unit for quantitative and qualitative stable isotope studies by gas chromatography-mass spectrometry. (2/11)

We have designed and constructed a stable isotope ratiometer-multiple ion detector unit, which can drive existing chromatograph-quadrupole or magnetic sector mass gas spectrometers to monitor up to six ions in turn. Each of the three pairs of ions can be selected for quantitation; thus three different or successive components can be analyzed in a single gas-chromatographic run. A background subtraction option permits the ion intensity in the absence of sample to be subtracted automatically during sample measurement. Displays of accumulated counts and isotope ratio are updated twice per second during the measurement and can be printed out at is conclusion. All six ions can be monitored in the analog mode by parallel outputs to a multipen recorder. Experience gained in the construction of this prototype indicates that such units could be commercially available for $10 000, or about a third to a sixth of the cost of even an inexpensive computer system.  (+info)

INVESTIGATION OF AN OPERATOR METHOD IN THE ANALYSIS OF BIOLOGICAL TRACER DATA. (3/11)

Some factors affecting the usefulness of a linear operator in the analysis of tracer data were evaluated. Application of the operator to a sum of two exponential components resulted in the separation of the rate constants with an accuracy of 10 to 15 per cent if they differed by a factor of at least 2 and the error in the data was about 2 per cent. A factor of 4 was necessary if the error in the data was 6 per cent, and of 6 if the error was 10 per cent. The ratio of amplitudes varied from near unity to equality with the ratio of rate constants. However, if the ratio of amplitudes was greater than the ratio of rate constants the method would not resolve the rate constants. Application of the operator to a sum of three exponential components was also considered.  (+info)

Neural networks: models and neurons show hybrid vigor in real time. (4/11)

Hybrid networks in which living neurons interact with digital or analog model neurons are providing insights into the role of neural and synaptic properties in shaping neural network activity.  (+info)

Extracting medication information from clinical text. (5/11)

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Nonlinear cable equations for axons. II. Computations and experiments with external current electrodes. (6/11)

We have investigated the steady-state potential and current distributions resulting from current injection into a close-fitting channel into which a squid axon is placed. Hybrid computer solutions of the cable equations, using the Hodgkin-Huxley equations to give the membrane current density, were in good agreement with experimental observations. A much better fit was obtained when the Hodgkin-Huxley leakage conductance was reduced fivefold.  (+info)

Ribosomal precursors and ribonucleic acid synthesis in Escherichia coli. (7/11)

Ribosomes and immature ribonucleoprotein particles were isolated from extracts of log-phase cells grown under various conditions. Quantitative measurements were made to determine the relative amounts of immature particles present in the extracts. The results indicate that the steady-state level of ribosomal precursors accounted for essentially a constant fraction of the total ribonucleic acid (RNA) of the cells. For cells with RNA-protein ratios between 0.43 and 0.65, about 1.6% of the total RNA occurred as immature ribonucleoprotein particles. Further, increased levels of immature particles were shown to be correlated with a reduced rate of RNA synthesis in cells recovering from chloramphenicol inhibition. The reduction was found to vary directly with the duration of pretreatment in chloramphenicol and, consequently, with the level of immature particles present in the cells.  (+info)

On-line acquisition of the output of AutoAnalyzers. (8/11)

A computer-based system of on-line acquisition of the output from AutoAnalyzers is described and discussed. Early experience suggests that many advantages accrue from such a system.  (+info)

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