Computer Simulation
Computer Peripherals
Research Design
Drug Design
Computer Systems
Computers, Handheld
Computer Terminals
Software
Computer-Aided Design
Computers, Analog
Diagnosis, Computer-Assisted
Algorithms
Computer Communication Networks
Computer Graphics
Computer-Assisted Instruction
Minicomputers
Information Systems
Internet
Reproducibility of Results
Models, Biological
Medical Records Systems, Computerized
Computers, Molecular
Questionnaires
Models, Molecular
Data Display
Human Engineering
Video Games
Prospective Studies
Neural Networks (Computer)
Computer Security
Treatment Outcome
Models, Theoretical
Cross-Sectional Studies
Computers, Hybrid
Image Processing, Computer-Assisted
Molecular Sequence Data
Sensitivity and Specificity
Cumulative Trauma Disorders
Surgery, Computer-Assisted
Risk Factors
Online Systems
Data Collection
Office Automation
Pilot Projects
Amino Acid Sequence
Hospital Information Systems
Computational Biology
Databases, Factual
Retrospective Studies
Models, Statistical
Cohort Studies
Base Sequence
Multimedia
Cross-Over Studies
Computer Storage Devices
Models, Genetic
Follow-Up Studies
Models, Anatomic
Information Storage and Retrieval
Epidemiologic Research Design
Television
Medical Informatics
Imaging, Three-Dimensional
Models, Cardiovascular
Data Interpretation, Statistical
Randomized Controlled Trials as Topic
Mathematics
Medical Informatics Applications
Sample Size
Ambulatory Care Information Systems
Analysis of Variance
Musculoskeletal Diseases
Feasibility Studies
Equipment Failure Analysis
Models, Chemical
Monte Carlo Method
Decision Support Systems, Clinical
Protein Conformation
Man-Machine Systems
Biomechanical Phenomena
Clinical Protocols
Automation
Communication Aids for Disabled
Video Recording
Thermodynamics
Signal Processing, Computer-Assisted
Proteins
Age Factors
Tomography, X-Ray Computed
Cost-Benefit Analysis
Protein Engineering
Outcome Assessment (Health Care)
Case-Control Studies
Binding Sites
Regression Analysis
Linear Models
Double-Blind Method
Attitude of Health Personnel
Longitudinal Studies
Pregnancy
Documentation
Prevalence
Neoplasms
Facility Design and Construction
Statistics as Topic
DNA
Structure-Activity Relationship
Shoulder Pain
Models, Neurological
Costs and Cost Analysis
Brain-Computer Interfaces
Quality Control
Expert Systems
Telemedicine
CD-ROM
Artificial Intelligence
Physiology
Predictive Value of Tests
Radiology Information Systems
Photography
Program Evaluation
Task Performance and Analysis
Point-of-Care Systems
Sex Factors
Clinical Trials as Topic
Risk Assessment
Netherlands
Observer Variation
Radiographic Image Enhancement
Logistic Models
Electronics
Evaluation Studies as Topic
Molecular Structure
Databases as Topic
Interviews as Topic
Workflow
Interior Design and Furnishings
Information Services
Nucleic Acid Conformation
Educational Technology
Reference Values
Neck Pain
Single-Blind Method
Finite Element Analysis
Protein Binding
Magnetic Resonance Imaging
Communication
Clinical Pharmacy Information Systems
Technology
Radiographic Image Interpretation, Computer-Assisted
Sequence Alignment
Sequence Analysis, DNA
Primary Health Care
Mutation
Health Knowledge, Attitudes, Practice
Cluster Analysis
Students, Medical
Image Interpretation, Computer-Assisted
Dose-Response Relationship, Drug
Peptides
Reminder Systems
Medical Informatics Computing
Crystallography, X-Ray
Asthenopia
MEDLINE
Database Management Systems
Severity of Illness Index
Analysis of electronic structures of physostigmine analogs. (1/779)
AIM: To elucidate the action mechanism and structural prerequisites of 21 physostigmine analogs as acetylcholinesterase inhibitors at the molecular level, and help the rational design of these dihydroindoline inhibitors. METHODS: Initial structures of these compounds were built and minimized by SYBYL 6.2 molecular modeling software. Conformations of those molecules with the highest predictive abilities in the Comparative Molecular Field Analysis model were chosen to the semiempirical quantum chemical calculations. RESULTS: (1) The highest occupied molecular orbital (HOMO) consisted mainly of the orbitals in phenyl group and N1 atom; the lowest unoccupied molecular orbital (LUMO) of the molecules was contributed from phenyl group and C11 atom. While the HOMO energies did not show any recognizable relationship with activity, the LUMO energies showed a decreased tendency with increasing activity. The active compounds showed lower LUMO energies. (2) The carbon atom (C11) had the most positive net atom charge. The most active compound had the most positive charge on this carbon, but had the lower charges on the carbonyl oxygen (O12) which was the most negative charge atom. (3) The bond order of carbon-oxygen bond (C11-O10) was invariant across the series of the compounds. (4) Compounds with too high or too low total dipole moment had lower activities, while the most active one had a lower molecular polarizability. CONCLUSION: A molecular model was suggested to explain the possible mode of action by which these compounds inhibit acetylcholinesterase. (+info)A 3D computer-aided design system applied to diagnosis and treatment planning in orthodontics and orthognathic surgery. (2/779)
The purpose of this article is to describe a newly developed 3D computer-aided design (CAD) system for the diagnostic set-up of casts in orthodontic diagnosis and treatment planning, and its preliminary clinical applications. The system comprises a measuring unit which obtains 3D information from the dental model using laser scanning, and a personal computer to generate the 3D graphics. When measuring the 3D shape of the model, to minimize blind sectors, the model is scanned from two different directions with the slit-ray laser beam by rotating the mounting angle of the model on the measuring device. For computed simulation of tooth movement, the representative planes, defined by the anatomical reference points, are formed for each individual tooth and are arranged along a guideline descriptive of the individual arch form. Subsequently, the 3D shape is imparted to each of the teeth arranged on the representative plane to form an arrangement of the 3D profile. When necessary, orthognathic surgery can be simulated by moving the mandibular dental arch three-dimensionally to establish the optimum occlusal relationship. Compared with hand-made set-up models, the computed diagnostic cast has advantages such as high-speed processing and quantitative evaluation on the amount of 3D movement of the individual tooth relative to the craniofacial plane. Trial clinical applications demonstrated that the use of this system facilitated the otherwise complicated and time-consuming mock surgery for treatment planning in orthognathic surgery. (+info)Targeting the HIV-protease in AIDS therapy: a current clinical perspective. (3/779)
This review deals with clinical applications of compounds that inhibit the action of the protease encoded within the genome of human immunodeficiency virus (HIV). The HIV-protease is essential for viral maturation and represents an important therapeutic target in the fight against AIDS. Following a brief overview of the enzyme structure and function, the article focuses on a number of peptide and non-peptide based HIV-protease inhibitors that are in current clinical use. These drugs are discussed both with respect to their efficacy in treatment of AIDS, and to problems related to insurgence of viral resistance and side effects seen to date in patient populations. (+info)Effect of polishing on cyclic fatigue strength of CAD/CAM ceramics. (4/779)
The biaxial flexural strength and cyclic fatigue biaxial flexural strength of CAD/CAM ceramics polished with #220, 400, 600 and 1000 diamond pads were measured in an effort to determine the effect of surface roughness on fatigue behavior of dental ceramics. The surface roughness was improved after polishing with a smaller diamond grain pad. The flexural strengths of the specimens polished with #220, 400, 600 and 1000 diamond pad were 75.2, 76.6, 82.2, and 83.3 MPa, respectively; the fatigue flexural strength of those with #220, 400, 600 and 1000 were 53.0, 58.1, 60.0, and 61.5 MPa, respectively. Both the flexural and fatigue flexural strengths increased with improvement of surface profile. These results suggest the importance of polishing of dental ceramics for not only the static strength but also the cyclic fatigue strength. (+info)Influence of filler content and gap dimension on wear resistance of resin composite luting cements around a CAD/CAM ceramic inlay restoration. (5/779)
We investigated the influence of filler content and gap dimension on the wear resistance of composite luting cement around CAD/CAM ceramic inlay restorations. Experimental hybrid dual-cured composite luting cements containing 60, 70, 72, 74 and 80 wt% of silanated barium-silica fillers were used for cementing CAD/CAM ceramic inlay into the cavity. The specimens involving inlay-cement-tooth interfaces were subjected to a three-body wear test. The relation between the interfacial gap dimension and wear loss was also investigated using 60, 70 and 80 wt% filled cements. The cements containing more than 70 wt% filler presented significantly higher wear resistance than 60 wt% filled cement. There was a positive linear relationship between gap dimension and wear loss, and the inclination of the regression line decreased with increasing filler content. These results indicated that the higher filler content of the cement increased the wear resistance and this desirable influence appeared more remarkably in the wider horizontal gap dimension. (+info)The Procera abutment--the fifth generation abutment for dental implants. (6/779)
The Branemark dental implant has undergone progressive development in terms of both the implant body itself and the components connecting the implant to the prosthesis. Many screw and abutment designs have been developed, with various degrees of success. About 15 years ago, CAD (computer-assisted design)-CAM (computer-assisted manufacture) technology was introduced to dentists. More recently CAD-CAM has been used in the manufacture of abutments for implants. This article reviews currently available techniques for creating the Procera custom abutment (Nobel Biocare, Goteborg, Sweden) and outlines appropriate applications for this type of implant. (+info)PrimeArray: genome-scale primer design for DNA-microarray construction. (7/779)
PrimeArray is a Windows program that computes oligonuceotide primer pairs for genome-scale gene amplification by the Polymerase Chain Reaction (PCR). The program supports the automated extraction of coding sequences (CDS) from various input-file formats and allows highly automated primer pair-optimization. (+info)Application of secondary structure prediction in antisense drug design targeting protein kinase C-alpha mRNA and QSAR analysis. (8/779)
AIM: To optimize the design of antisense drug targeting protein kinase C-alpha (PKC-alpha) mRNA and obtain better antisense drugs than ISIS3521 that is undergoing clinical trials. METHODS: RNAstructure (version 3.21, 1999) was utilized to predict the optimal and suboptimal secondary structures of human PKC alpha mRNA (GenBank, X52479), and 29 antisense phosphorothioate oligodeoxynucleotides (S-ODN) targeting the secondary structural elements, 3 partly matched S-ODN and 1 scrambled 3521 were designed. ISIS3521 was set as positive control. Mean (n = 3-5) 50% inhibitory effects on proliferation of A549 cells (IC50) of S-ODN were evaluated. Free energies (delta G degree 37) relating to the target secondary structural elements were calculated according to the nearest neighbor model. The quantitative structure-activity relationship (QSAR) analysis through multiple regression was obtained by SPSS. RESULTS: Three S-ODN; (5'-AGCCCA-GCCGCTTGGCTGGG-3', 5'-AGGAGTGCAGCTGC-GTCAAG-3', 5'-TCAGAGGG-ACTGATGACTTT-3') had lower IC50[(48 +/- 7), (50 +/- 4), (64 +/- 2.7) nmol.L-1, respectively] than that of ISIS3521 [(81 +/- 25) nmol.L-1]. The number of bases comprising the target secondary structural element bulge loop, internal loop, and knot, the free energy of S-ODN (delta G degree 37S), and reaction (delta G degree 37R) were important parameters in QSAR equation. In the multiple regression, R was 0.68, P = 0.0193. Not tally with the equation, two S-ODN (5'-TCAAATGGAGG-CTGCCCGGC-3', 5'-AAAACGTCAGCCATGGTCCC-3') with favorable target structures and delta G degree 37 did not behave good activities. CONCLUSION: Computer aided design was helpful to obtain S-ODN with better in vitro effect than current positive drug. The degree of instability of secondary structural elements and delta G degree 37 were important factors for drug activity. Other important factors needed for further investigation. (+info)The term "cumulative" refers to the gradual buildup of damage over time, as opposed to a single traumatic event that causes immediate harm. The damage can result from repetitive motions, vibrations, compressive forces, or other forms of stress that accumulate and lead to tissue injury and inflammation.
Some common examples of CTDs include:
1. Carpal tunnel syndrome: A condition that affects the wrist and hand, caused by repetitive motion and compression of the median nerve.
2. Tendinitis: Inflammation of a tendon, often caused by repetitive motion or overuse.
3. Bursitis: Inflammation of a bursa, a fluid-filled sac that cushions joints and reduces friction between tissues.
4. Tennis elbow: A condition characterized by inflammation of the tendons on the outside of the elbow, caused by repetitive gripping or twisting motions.
5. Plantar fasciitis: Inflammation of the plantar fascia, a band of tissue that runs along the bottom of the foot, caused by repetitive strain and overuse.
6. Repetitive stress injuries: A broad category of injuries caused by repetitive motion, such as typing or using a computer mouse.
7. Occupational asthma: A condition caused by inhaling allergens or irritants in the workplace, leading to inflammation and narrowing of the airways.
8. Hearing loss: Damage to the inner ear or auditory nerve caused by exposure to loud noises over time.
9. Vibration white finger: A condition that affects the hands, causing whiteness or loss of blood flow in the fingers due to exposure to vibrating tools.
10. Carpal tunnel syndrome: Compression of the median nerve in the wrist, leading to numbness, tingling, and weakness in the hand and arm.
It's important to note that these conditions can have a significant impact on an individual's quality of life, ability to work, and overall well-being. If you are experiencing any of these conditions, it is important to seek medical attention to receive proper diagnosis and treatment.
1. Osteoarthritis: A degenerative joint disease that affects the cartilage and bone in the joints, leading to pain, stiffness, and limited mobility.
2. Rheumatoid arthritis: An autoimmune disorder that causes inflammation in the joints, leading to pain, swelling, and deformity.
3. Fibromyalgia: A chronic condition characterized by widespread muscle pain, fatigue, and sleep disturbances.
4. Tendinitis: Inflammation of a tendon, which can cause pain and stiffness in the affected area.
5. Bursitis: Inflammation of the fluid-filled sacs (bursae) that cushion joints, leading to pain, swelling, and limited mobility.
6. Carpal tunnel syndrome: Compression of the median nerve in the wrist, leading to numbness, tingling, and weakness in the hand and fingers.
7. Sprains and strains: Injuries to the ligaments or muscles, often caused by sudden twisting or overstretching.
8. Back pain: Pain in the back that can be caused by a variety of factors, such as muscle strain, herniated discs, or spinal stenosis.
9. Osteoporosis: A condition characterized by weak and brittle bones, leading to an increased risk of fractures.
10. Clubfoot: A congenital deformity in which the foot is turned inward and downward.
These are just a few examples of musculoskeletal diseases, and there are many more conditions that can affect the muscles, bones, and joints. Treatment options for these conditions can range from conservative methods such as physical therapy and medication to surgical interventions. It's important to seek medical attention if you experience any persistent or severe symptoms in your musculoskeletal system.
Neoplasm refers to an abnormal growth of cells that can be benign (non-cancerous) or malignant (cancerous). Neoplasms can occur in any part of the body and can affect various organs and tissues. The term "neoplasm" is often used interchangeably with "tumor," but while all tumors are neoplasms, not all neoplasms are tumors.
Types of Neoplasms
There are many different types of neoplasms, including:
1. Carcinomas: These are malignant tumors that arise in the epithelial cells lining organs and glands. Examples include breast cancer, lung cancer, and colon cancer.
2. Sarcomas: These are malignant tumors that arise in connective tissue, such as bone, cartilage, and fat. Examples include osteosarcoma (bone cancer) and soft tissue sarcoma.
3. Lymphomas: These are cancers of the immune system, specifically affecting the lymph nodes and other lymphoid tissues. Examples include Hodgkin lymphoma and non-Hodgkin lymphoma.
4. Leukemias: These are cancers of the blood and bone marrow that affect the white blood cells. Examples include acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL).
5. Melanomas: These are malignant tumors that arise in the pigment-producing cells called melanocytes. Examples include skin melanoma and eye melanoma.
Causes and Risk Factors of Neoplasms
The exact causes of neoplasms are not fully understood, but there are several known risk factors that can increase the likelihood of developing a neoplasm. These include:
1. Genetic predisposition: Some people may be born with genetic mutations that increase their risk of developing certain types of neoplasms.
2. Environmental factors: Exposure to certain environmental toxins, such as radiation and certain chemicals, can increase the risk of developing a neoplasm.
3. Infection: Some neoplasms are caused by viruses or bacteria. For example, human papillomavirus (HPV) is a common cause of cervical cancer.
4. Lifestyle factors: Factors such as smoking, excessive alcohol consumption, and a poor diet can increase the risk of developing certain types of neoplasms.
5. Family history: A person's risk of developing a neoplasm may be higher if they have a family history of the condition.
Signs and Symptoms of Neoplasms
The signs and symptoms of neoplasms can vary depending on the type of cancer and where it is located in the body. Some common signs and symptoms include:
1. Unusual lumps or swelling
2. Pain
3. Fatigue
4. Weight loss
5. Change in bowel or bladder habits
6. Unexplained bleeding
7. Coughing up blood
8. Hoarseness or a persistent cough
9. Changes in appetite or digestion
10. Skin changes, such as a new mole or a change in the size or color of an existing mole.
Diagnosis and Treatment of Neoplasms
The diagnosis of a neoplasm usually involves a combination of physical examination, imaging tests (such as X-rays, CT scans, or MRI scans), and biopsy. A biopsy involves removing a small sample of tissue from the suspected tumor and examining it under a microscope for cancer cells.
The treatment of neoplasms depends on the type, size, location, and stage of the cancer, as well as the patient's overall health. Some common treatments include:
1. Surgery: Removing the tumor and surrounding tissue can be an effective way to treat many types of cancer.
2. Chemotherapy: Using drugs to kill cancer cells can be effective for some types of cancer, especially if the cancer has spread to other parts of the body.
3. Radiation therapy: Using high-energy radiation to kill cancer cells can be effective for some types of cancer, especially if the cancer is located in a specific area of the body.
4. Immunotherapy: Boosting the body's immune system to fight cancer can be an effective treatment for some types of cancer.
5. Targeted therapy: Using drugs or other substances to target specific molecules on cancer cells can be an effective treatment for some types of cancer.
Prevention of Neoplasms
While it is not always possible to prevent neoplasms, there are several steps that can reduce the risk of developing cancer. These include:
1. Avoiding exposure to known carcinogens (such as tobacco smoke and radiation)
2. Maintaining a healthy diet and lifestyle
3. Getting regular exercise
4. Not smoking or using tobacco products
5. Limiting alcohol consumption
6. Getting vaccinated against certain viruses that are associated with cancer (such as human papillomavirus, or HPV)
7. Participating in screening programs for early detection of cancer (such as mammograms for breast cancer and colonoscopies for colon cancer)
8. Avoiding excessive exposure to sunlight and using protective measures such as sunscreen and hats to prevent skin cancer.
It's important to note that not all cancers can be prevented, and some may be caused by factors that are not yet understood or cannot be controlled. However, by taking these steps, individuals can reduce their risk of developing cancer and improve their overall health and well-being.
The shoulder is a complex joint that consists of several bones, muscles, tendons, and ligaments, which work together to provide a wide range of motion and stability. Any disruption in this delicate balance can cause pain and dysfunction.
Some common causes of shoulder pain include:
1. Rotator cuff injuries: The rotator cuff is a group of muscles and tendons that surround the shoulder joint, providing stability and mobility. Injuries to the rotator cuff can cause pain and weakness in the shoulder.
2. Bursitis: Bursae are small fluid-filled sacs that cushion the joints and reduce friction between the bones, muscles, and tendons. Inflammation of the bursae (bursitis) can cause pain and swelling in the shoulder.
3. Tendinitis: Tendinitis is inflammation of the tendons, which connect the muscles to the bones. Tendinitis in the shoulder can cause pain and stiffness.
4. Dislocations: A dislocation occurs when the ball of the humerus (upper arm bone) is forced out of the shoulder socket. This can cause severe pain, swelling, and limited mobility.
5. Osteoarthritis: Osteoarthritis is a degenerative condition that affects the joints, including the shoulder. It can cause pain, stiffness, and limited mobility.
6. Frozen shoulder: Also known as adhesive capsulitis, frozen shoulder is a condition where the connective tissue in the shoulder joint becomes inflamed and scarred, leading to pain and stiffness.
7. Labral tears: The labrum is a cartilage ring that surrounds the shoulder socket, providing stability and support. Tears to the labrum can cause pain and instability in the shoulder.
8. Fractures: Fractures of the humerus, clavicle, or scapula (shoulder blade) can cause pain, swelling, and limited mobility.
9. Rotator cuff tears: The rotator cuff is a group of muscles and tendons that provide stability and support to the shoulder joint. Tears to the rotator cuff can cause pain and weakness in the shoulder.
10. Impingement syndrome: Impingement syndrome occurs when the tendons of the rotator cuff become pinched or compressed as they pass through the shoulder joint, leading to pain and inflammation.
These are just a few examples of common shoulder injuries and conditions. If you're experiencing shoulder pain or stiffness, it's important to see a doctor for proper diagnosis and treatment.
1. Asbestosis: a lung disease caused by inhaling asbestos fibers.
2. Carpal tunnel syndrome: a nerve disorder caused by repetitive motion and pressure on the wrist.
3. Mesothelioma: a type of cancer caused by exposure to asbestos.
4. Pneumoconiosis: a lung disease caused by inhaling dust from mining or other heavy industries.
5. Repetitive strain injuries: injuries caused by repetitive motions, such as typing or using vibrating tools.
6. Skin conditions: such as skin irritation and dermatitis caused by exposure to chemicals or other substances in the workplace.
7. Hearing loss: caused by loud noises in the workplace.
8. Back injuries: caused by lifting, bending, or twisting.
9. Respiratory problems: such as asthma and other breathing difficulties caused by exposure to chemicals or dust in the workplace.
10. Cancer: caused by exposure to carcinogens such as radiation, certain chemicals, or heavy metals in the workplace.
Occupational diseases can be difficult to diagnose and treat, as they often develop gradually over time and may not be immediately attributed to the work environment. In some cases, these diseases may not appear until years after exposure has ended. It is important for workers to be aware of the potential health risks associated with their job and take steps to protect themselves, such as wearing protective gear, following safety protocols, and seeking regular medical check-ups. Employers also have a responsibility to provide a safe work environment and follow strict regulations to prevent the spread of occupational diseases.
There are several types of neck pain, including:
* Acute neck pain: This is a sudden onset of pain in the neck, often caused by an injury or strain.
* Chronic neck pain: This is persistent pain in the neck that lasts for more than 3 months.
* Mechanical neck pain: This is pain caused by misalignment or degeneration of the spinal bones and joints in the neck.
* Non-mechanical neck pain: This is pain that is not caused by a specific structural problem, but rather by factors such as poor posture, muscle strain, or pinched nerves.
Neck pain can be treated with a variety of methods, including:
* Medications such as pain relievers and anti-inflammatory drugs
* Physical therapy to improve range of motion and strength
* Chiropractic care to realign the spine and relieve pressure on nerves
* Massage therapy to relax muscles and improve circulation
* Lifestyle changes such as improving posture, losing weight, and taking regular breaks to rest and stretch.
It is important to seek medical attention if neck pain is severe, persistent, or accompanied by other symptoms such as numbness, tingling, or weakness in the arms or legs.
Asthenopia is a common condition that affects millions of people worldwide, particularly those who spend long hours working on computers, reading, or engaging in other visually demanding activities. It can also be triggered by other factors such as poor lighting, incorrect posture, and eye conditions like myopia (nearsightedness) or hyperopia (farsightedness).
While asthenopia is usually a temporary condition that resolves on its own after resting the eyes, it can sometimes be a symptom of a more serious underlying eye condition. Therefore, if you experience persistent or severe symptoms of asthenopia, it's important to consult an eye care professional for proper evaluation and treatment.
Treatment options for asthenopia may include taking regular breaks to rest the eyes, adjusting lighting conditions, using artificial tears to lubricate dry eyes, and making changes to your workspace or reading habits to reduce visual strain. In some cases, prescription eyewear or vision therapy may be necessary to address underlying eye conditions that contribute to asthenopia.
The burden of chronic diseases is significant, with over 70% of deaths worldwide attributed to them, according to the World Health Organization (WHO). In addition to the physical and emotional toll they take on individuals and their families, chronic diseases also pose a significant economic burden, accounting for a large proportion of healthcare expenditure.
In this article, we will explore the definition and impact of chronic diseases, as well as strategies for managing and living with them. We will also discuss the importance of early detection and prevention, as well as the role of healthcare providers in addressing the needs of individuals with chronic diseases.
What is a Chronic Disease?
A chronic disease is a condition that lasts for an extended period of time, often affecting daily life and activities. Unlike acute diseases, which have a specific beginning and end, chronic diseases are long-term and persistent. Examples of chronic diseases include:
1. Diabetes
2. Heart disease
3. Arthritis
4. Asthma
5. Cancer
6. Chronic obstructive pulmonary disease (COPD)
7. Chronic kidney disease (CKD)
8. Hypertension
9. Osteoporosis
10. Stroke
Impact of Chronic Diseases
The burden of chronic diseases is significant, with over 70% of deaths worldwide attributed to them, according to the WHO. In addition to the physical and emotional toll they take on individuals and their families, chronic diseases also pose a significant economic burden, accounting for a large proportion of healthcare expenditure.
Chronic diseases can also have a significant impact on an individual's quality of life, limiting their ability to participate in activities they enjoy and affecting their relationships with family and friends. Moreover, the financial burden of chronic diseases can lead to poverty and reduce economic productivity, thus having a broader societal impact.
Addressing Chronic Diseases
Given the significant burden of chronic diseases, it is essential that we address them effectively. This requires a multi-faceted approach that includes:
1. Lifestyle modifications: Encouraging healthy behaviors such as regular physical activity, a balanced diet, and smoking cessation can help prevent and manage chronic diseases.
2. Early detection and diagnosis: Identifying risk factors and detecting diseases early can help prevent or delay their progression.
3. Medication management: Effective medication management is crucial for controlling symptoms and slowing disease progression.
4. Multi-disciplinary care: Collaboration between healthcare providers, patients, and families is essential for managing chronic diseases.
5. Health promotion and disease prevention: Educating individuals about the risks of chronic diseases and promoting healthy behaviors can help prevent their onset.
6. Addressing social determinants of health: Social determinants such as poverty, education, and employment can have a significant impact on health outcomes. Addressing these factors is essential for reducing health disparities and improving overall health.
7. Investing in healthcare infrastructure: Investing in healthcare infrastructure, technology, and research is necessary to improve disease detection, diagnosis, and treatment.
8. Encouraging policy change: Policy changes can help create supportive environments for healthy behaviors and reduce the burden of chronic diseases.
9. Increasing public awareness: Raising public awareness about the risks and consequences of chronic diseases can help individuals make informed decisions about their health.
10. Providing support for caregivers: Chronic diseases can have a significant impact on family members and caregivers, so providing them with support is essential for improving overall health outcomes.
Conclusion
Chronic diseases are a major public health burden that affect millions of people worldwide. Addressing these diseases requires a multi-faceted approach that includes lifestyle changes, addressing social determinants of health, investing in healthcare infrastructure, encouraging policy change, increasing public awareness, and providing support for caregivers. By taking a comprehensive approach to chronic disease prevention and management, we can improve the health and well-being of individuals and communities worldwide.
There are several different types of obesity, including:
1. Central obesity: This type of obesity is characterized by excess fat around the waistline, which can increase the risk of health problems such as type 2 diabetes and cardiovascular disease.
2. Peripheral obesity: This type of obesity is characterized by excess fat in the hips, thighs, and arms.
3. Visceral obesity: This type of obesity is characterized by excess fat around the internal organs in the abdominal cavity.
4. Mixed obesity: This type of obesity is characterized by both central and peripheral obesity.
Obesity can be caused by a variety of factors, including genetics, lack of physical activity, poor diet, sleep deprivation, and certain medications. Treatment for obesity typically involves a combination of lifestyle changes, such as increased physical activity and a healthy diet, and in some cases, medication or surgery may be necessary to achieve weight loss.
Preventing obesity is important for overall health and well-being, and can be achieved through a variety of strategies, including:
1. Eating a healthy, balanced diet that is low in added sugars, saturated fats, and refined carbohydrates.
2. Engaging in regular physical activity, such as walking, jogging, or swimming.
3. Getting enough sleep each night.
4. Managing stress levels through relaxation techniques, such as meditation or deep breathing.
5. Avoiding excessive alcohol consumption and quitting smoking.
6. Monitoring weight and body mass index (BMI) on a regular basis to identify any changes or potential health risks.
7. Seeking professional help from a healthcare provider or registered dietitian for personalized guidance on weight management and healthy lifestyle choices.
Type 2 diabetes can be managed through a combination of diet, exercise, and medication. In some cases, lifestyle changes may be enough to control blood sugar levels, while in other cases, medication or insulin therapy may be necessary. Regular monitoring of blood sugar levels and follow-up with a healthcare provider are important for managing the condition and preventing complications.
Common symptoms of type 2 diabetes include:
* Increased thirst and urination
* Fatigue
* Blurred vision
* Cuts or bruises that are slow to heal
* Tingling or numbness in the hands and feet
* Recurring skin, gum, or bladder infections
If left untreated, type 2 diabetes can lead to a range of complications, including:
* Heart disease and stroke
* Kidney damage and failure
* Nerve damage and pain
* Eye damage and blindness
* Foot damage and amputation
The exact cause of type 2 diabetes is not known, but it is believed to be linked to a combination of genetic and lifestyle factors, such as:
* Obesity and excess body weight
* Lack of physical activity
* Poor diet and nutrition
* Age and family history
* Certain ethnicities (e.g., African American, Hispanic/Latino, Native American)
* History of gestational diabetes or delivering a baby over 9 lbs.
There is no cure for type 2 diabetes, but it can be managed and controlled through a combination of lifestyle changes and medication. With proper treatment and self-care, people with type 2 diabetes can lead long, healthy lives.
Types: There are several types of arm injuries, including:
1. Fractures: A break in one or more bones of the arm.
2. Sprains: Stretching or tearing of ligaments that connect bones to other tissues.
3. Strains: Tears in muscles or tendons.
4. Dislocations: When a bone is forced out of its normal position in the joint.
5. Tendinitis: Inflammation of the tendons, which can cause pain and stiffness in the arm.
6. Bursitis: Inflammation of the fluid-filled sacs (bursae) that cushion the joints and reduce friction.
7. Cuts or lacerations: Open wounds on the skin or other tissues of the arm.
8. Burns: Damage to the skin and underlying tissues caused by heat, chemicals, or electricity.
9. Nerve injuries: Damage to the nerves that control movement and sensation in the arm.
10. Infections: Bacterial, viral, or fungal infections that can affect any part of the arm.
Symptoms: The symptoms of arm injuries can vary depending on the type and severity of the injury. Some common symptoms include pain, swelling, bruising, limited mobility, deformity, and difficulty moving the arm.
Diagnosis: A healthcare professional will typically perform a physical examination and may use imaging tests such as X-rays, CT scans, or MRI to diagnose arm injuries.
Treatment: Treatment for arm injuries can range from conservative methods such as rest, ice, compression, and elevation (RICE) to surgical interventions. The goal of treatment is to relieve pain, promote healing, and restore function to the affected arm.
There are different types of Breast Neoplasms such as:
1. Fibroadenomas: These are benign tumors that are made up of glandular and fibrous tissues. They are usually small and round, with a smooth surface, and can be moved easily under the skin.
2. Cysts: These are fluid-filled sacs that can develop in both breast tissue and milk ducts. They are usually benign and can disappear on their own or be drained surgically.
3. Ductal Carcinoma In Situ (DCIS): This is a precancerous condition where abnormal cells grow inside the milk ducts. If left untreated, it can progress to invasive breast cancer.
4. Invasive Ductal Carcinoma (IDC): This is the most common type of breast cancer and starts in the milk ducts but grows out of them and invades surrounding tissue.
5. Invasive Lobular Carcinoma (ILC): It originates in the milk-producing glands (lobules) and grows out of them, invading nearby tissue.
Breast Neoplasms can cause various symptoms such as a lump or thickening in the breast or underarm area, skin changes like redness or dimpling, change in size or shape of one or both breasts, discharge from the nipple, and changes in the texture or color of the skin.
Treatment options for Breast Neoplasms may include surgery such as lumpectomy, mastectomy, or breast-conserving surgery, radiation therapy which uses high-energy beams to kill cancer cells, chemotherapy using drugs to kill cancer cells, targeted therapy which uses drugs or other substances to identify and attack cancer cells while minimizing harm to normal cells, hormone therapy, immunotherapy, and clinical trials.
It is important to note that not all Breast Neoplasms are cancerous; some are benign (non-cancerous) tumors that do not spread or grow.
There are several different types of pain, including:
1. Acute pain: This type of pain is sudden and severe, and it usually lasts for a short period of time. It can be caused by injuries, surgery, or other forms of tissue damage.
2. Chronic pain: This type of pain persists over a long period of time, often lasting more than 3 months. It can be caused by conditions such as arthritis, fibromyalgia, or nerve damage.
3. Neuropathic pain: This type of pain results from damage to the nervous system, and it can be characterized by burning, shooting, or stabbing sensations.
4. Visceral pain: This type of pain originates in the internal organs, and it can be difficult to localize.
5. Psychogenic pain: This type of pain is caused by psychological factors such as stress, anxiety, or depression.
The medical field uses a range of methods to assess and manage pain, including:
1. Pain rating scales: These are numerical scales that patients use to rate the intensity of their pain.
2. Pain diaries: These are records that patients keep to track their pain over time.
3. Clinical interviews: Healthcare providers use these to gather information about the patient's pain experience and other relevant symptoms.
4. Physical examination: This can help healthcare providers identify any underlying causes of pain, such as injuries or inflammation.
5. Imaging studies: These can be used to visualize the body and identify any structural abnormalities that may be contributing to the patient's pain.
6. Medications: There are a wide range of medications available to treat pain, including analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs), and muscle relaxants.
7. Alternative therapies: These can include acupuncture, massage, and physical therapy.
8. Interventional procedures: These are minimally invasive procedures that can be used to treat pain, such as nerve blocks and spinal cord stimulation.
It is important for healthcare providers to approach pain management with a multi-modal approach, using a combination of these methods to address the physical, emotional, and social aspects of pain. By doing so, they can help improve the patient's quality of life and reduce their suffering.
Body weight is an important health indicator, as it can affect an individual's risk for certain medical conditions, such as obesity, diabetes, and cardiovascular disease. Maintaining a healthy body weight is essential for overall health and well-being, and there are many ways to do so, including a balanced diet, regular exercise, and other lifestyle changes.
There are several ways to measure body weight, including:
1. Scale: This is the most common method of measuring body weight, and it involves standing on a scale that displays the individual's weight in kg or lb.
2. Body fat calipers: These are used to measure body fat percentage by pinching the skin at specific points on the body.
3. Skinfold measurements: This method involves measuring the thickness of the skin folds at specific points on the body to estimate body fat percentage.
4. Bioelectrical impedance analysis (BIA): This is a non-invasive method that uses electrical impulses to measure body fat percentage.
5. Dual-energy X-ray absorptiometry (DXA): This is a more accurate method of measuring body composition, including bone density and body fat percentage.
It's important to note that body weight can fluctuate throughout the day due to factors such as water retention, so it's best to measure body weight at the same time each day for the most accurate results. Additionally, it's important to use a reliable scale or measuring tool to ensure accurate measurements.
There are several types of diabetes mellitus, including:
1. Type 1 DM: This is an autoimmune condition in which the body's immune system attacks and destroys the cells in the pancreas that produce insulin, resulting in a complete deficiency of insulin production. It typically develops in childhood or adolescence, and patients with this condition require lifelong insulin therapy.
2. Type 2 DM: This is the most common form of diabetes, accounting for around 90% of all cases. It is caused by a combination of insulin resistance (where the body's cells do not respond properly to insulin) and impaired insulin secretion. It is often associated with obesity, physical inactivity, and a diet high in sugar and unhealthy fats.
3. Gestational DM: This type of diabetes develops during pregnancy, usually in the second or third trimester. Hormonal changes and insulin resistance can cause blood sugar levels to rise, putting both the mother and baby at risk.
4. LADA (Latent Autoimmune Diabetes in Adults): This is a form of type 1 DM that develops in adults, typically after the age of 30. It shares features with both type 1 and type 2 DM.
5. MODY (Maturity-Onset Diabetes of the Young): This is a rare form of diabetes caused by genetic mutations that affect insulin production. It typically develops in young adulthood and can be managed with lifestyle changes and/or medication.
The symptoms of diabetes mellitus can vary depending on the severity of the condition, but may include:
1. Increased thirst and urination
2. Fatigue
3. Blurred vision
4. Cuts or bruises that are slow to heal
5. Tingling or numbness in hands and feet
6. Recurring skin, gum, or bladder infections
7. Flu-like symptoms such as weakness, dizziness, and stomach pain
8. Dark, velvety skin patches (acanthosis nigricans)
9. Yellowish color of the skin and eyes (jaundice)
10. Delayed healing of cuts and wounds
If left untreated, diabetes mellitus can lead to a range of complications, including:
1. Heart disease and stroke
2. Kidney damage and failure
3. Nerve damage (neuropathy)
4. Eye damage (retinopathy)
5. Foot damage (neuropathic ulcers)
6. Cognitive impairment and dementia
7. Increased risk of infections and other diseases, such as pneumonia, gum disease, and urinary tract infections.
It is important to note that not all individuals with diabetes will experience these complications, and that proper management of the condition can greatly reduce the risk of developing these complications.
Disease progression can be classified into several types based on the pattern of worsening:
1. Chronic progressive disease: In this type, the disease worsens steadily over time, with a gradual increase in symptoms and decline in function. Examples include rheumatoid arthritis, osteoarthritis, and Parkinson's disease.
2. Acute progressive disease: This type of disease worsens rapidly over a short period, often followed by periods of stability. Examples include sepsis, acute myocardial infarction (heart attack), and stroke.
3. Cyclical disease: In this type, the disease follows a cycle of worsening and improvement, with periodic exacerbations and remissions. Examples include multiple sclerosis, lupus, and rheumatoid arthritis.
4. Recurrent disease: This type is characterized by episodes of worsening followed by periods of recovery. Examples include migraine headaches, asthma, and appendicitis.
5. Catastrophic disease: In this type, the disease progresses rapidly and unpredictably, with a poor prognosis. Examples include cancer, AIDS, and organ failure.
Disease progression can be influenced by various factors, including:
1. Genetics: Some diseases are inherited and may have a predetermined course of progression.
2. Lifestyle: Factors such as smoking, lack of exercise, and poor diet can contribute to disease progression.
3. Environmental factors: Exposure to toxins, allergens, and other environmental stressors can influence disease progression.
4. Medical treatment: The effectiveness of medical treatment can impact disease progression, either by slowing or halting the disease process or by causing unintended side effects.
5. Co-morbidities: The presence of multiple diseases or conditions can interact and affect each other's progression.
Understanding the type and factors influencing disease progression is essential for developing effective treatment plans and improving patient outcomes.
1. Coronary artery disease: The narrowing or blockage of the coronary arteries, which supply blood to the heart.
2. Heart failure: A condition in which the heart is unable to pump enough blood to meet the body's needs.
3. Arrhythmias: Abnormal heart rhythms that can be too fast, too slow, or irregular.
4. Heart valve disease: Problems with the heart valves that control blood flow through the heart.
5. Heart muscle disease (cardiomyopathy): Disease of the heart muscle that can lead to heart failure.
6. Congenital heart disease: Defects in the heart's structure and function that are present at birth.
7. Peripheral artery disease: The narrowing or blockage of blood vessels that supply oxygen and nutrients to the arms, legs, and other organs.
8. Deep vein thrombosis (DVT): A blood clot that forms in a deep vein, usually in the leg.
9. Pulmonary embolism: A blockage in one of the arteries in the lungs, which can be caused by a blood clot or other debris.
10. Stroke: A condition in which there is a lack of oxygen to the brain due to a blockage or rupture of blood vessels.
HIV (human immunodeficiency virus) infection is a condition in which the body is infected with HIV, a type of retrovirus that attacks the body's immune system. HIV infection can lead to AIDS (acquired immunodeficiency syndrome), a condition in which the immune system is severely damaged and the body is unable to fight off infections and diseases.
There are several ways that HIV can be transmitted, including:
1. Sexual contact with an infected person
2. Sharing of needles or other drug paraphernalia with an infected person
3. Mother-to-child transmission during pregnancy, childbirth, or breastfeeding
4. Blood transfusions ( although this is rare in developed countries due to screening processes)
5. Organ transplantation (again, rare)
The symptoms of HIV infection can be mild at first and may not appear until several years after infection. These symptoms can include:
1. Fever
2. Fatigue
3. Swollen glands in the neck, armpits, and groin
4. Rash
5. Muscle aches and joint pain
6. Night sweats
7. Diarrhea
8. Weight loss
If left untreated, HIV infection can progress to AIDS, which is a life-threatening condition that can cause a wide range of symptoms, including:
1. Opportunistic infections (such as pneumocystis pneumonia)
2. Cancer (such as Kaposi's sarcoma)
3. Wasting syndrome
4. Neurological problems (such as dementia and seizures)
HIV infection is diagnosed through a combination of blood tests and physical examination. Treatment typically involves antiretroviral therapy (ART), which is a combination of medications that work together to suppress the virus and slow the progression of the disease.
Prevention methods for HIV infection include:
1. Safe sex practices, such as using condoms and dental dams
2. Avoiding sharing needles or other drug-injecting equipment
3. Avoiding mother-to-child transmission during pregnancy, childbirth, or breastfeeding
4. Post-exposure prophylaxis (PEP), which is a short-term treatment that can prevent infection after potential exposure to the virus
5. Pre-exposure prophylaxis (PrEP), which is a daily medication that can prevent infection in people who are at high risk of being exposed to the virus.
It's important to note that HIV infection is manageable with proper treatment and care, and that people living with HIV can lead long and healthy lives. However, it's important to be aware of the risks and take steps to prevent transmission.
Symptoms of type 1 diabetes can include increased thirst and urination, blurred vision, fatigue, weight loss, and skin infections. If left untreated, type 1 diabetes can lead to serious complications such as kidney damage, nerve damage, and blindness.
Type 1 diabetes is diagnosed through a combination of physical examination, medical history, and laboratory tests such as blood glucose measurements and autoantibody tests. Treatment typically involves insulin therapy, which can be administered via injections or an insulin pump, as well as regular monitoring of blood glucose levels and appropriate lifestyle modifications such as a healthy diet and regular exercise.
Recurrence can also refer to the re-emergence of symptoms in a previously treated condition, such as a chronic pain condition that returns after a period of remission.
In medical research, recurrence is often studied to understand the underlying causes of disease progression and to develop new treatments and interventions to prevent or delay its return.
Being overweight can increase the risk of various health problems, such as heart disease, type 2 diabetes, high blood pressure, and certain types of cancer. It can also affect a person's mental health and overall quality of life.
There are several ways to assess whether someone is overweight or not. One common method is using the BMI, which is calculated based on height and weight. Another method is measuring body fat percentage, which can be done with specialized tools such as skinfold calipers or bioelectrical impedance analysis (BIA).
Losing weight and maintaining a healthy weight can be achieved through a combination of diet, exercise, and lifestyle changes. Some examples of healthy weight loss strategies include:
* Eating a balanced diet that is high in fruits, vegetables, whole grains, and lean protein sources
* Engaging in regular physical activity, such as walking, running, swimming, or weight training
* Avoiding fad diets and quick fixes
* Getting enough sleep and managing stress levels
* Setting realistic weight loss goals and tracking progress over time.
Computer-aided design
Computer-aided architectural design
Constraint (computer-aided design)
Computer-aided industrial design
Responsive computer-aided design
Computer-aided garden design
Center for Computer-Aided Design
Behavioral modeling in computer-aided design
International Conference on Computer-Aided Design
Comparison of computer-aided design software
Association for Computer Aided Design In Architecture
IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems
Computer-aided technologies
Computer-aided manufacturing
Computer-aided architectural engineering
Computer-aided inspection
Architectural design optimization
Curvature
Automation
Cyber-physical system
Matrix-free methods
Biarc
Conformal cooling channel
Design for additive manufacturing
Cutter location
Incremental sheet forming
Franz-Erich Wolter
Generative design
STEP-NC
Object database
Waterfield Library
Technopark, Trivandrum
Symbolics
El Paso, Texas
PLATO (computer system)
Multimethodology
Cyberpunk 2077
Scuba set
Comparison of 3D computer graphics software
Delgo
Ioanna Morfessis
Kew Gardens
Neodymium
Rehabilitation psychology
2015 in aviation
USS Constitution
Blueprint
Cyprus Airways (1947-2015)
Users' Guides to the Medical Literature
Alan Eppes
Lalbhai Dalpatbhai College of Engineering
GRASP (SAT solver)
Wood Badge (Boy Scouts of America)
Logo (programming language)
Digital video recorder
Maine School Administrative District 46
NetObjects Fusion
Super Bowl XVIII
History of the automobile
Pratham
Computer-Aided Drafting and Design | Full-time | Certificate
LLNL gears up for next generation of computer-aided design and engineering | Lawrence Livermore National Laboratory
Planit : Courses : Computer Aided Architectural Design and Technology (New College Lanarkshire)
IISER Pune's Efforts against COVID-19: Computer Aided Designs for a Mechanical Ventilator - News - IISER Pune
Computer Aided Design and Manufacturing - SARCAR,...
Computer aided optimal design of high power density EMI filters
Computer-Aided Product Designing
Computer Aided Design Applications - Break2Up
Computer aided design - The Builder's Daily
Computer‐Aided Design (CAD) | Pocket Dentistry
Computer-aided selection | Furniture Design Ideas
February 2009 entries (kottke.org)
CAD|CAM Computer Aided Design & Manufacturing Services | CustomNC
MPG.eBooks - Description: Computer aided design and manufacturing
CAD (Computer-Aided Design) drawings - Innovations and More
ARCHITECTURAL PROJECT -3 | SCHOOL OF COMPUTER AIDED DESIGN
Computer Aided Design (CAD) | Page 2 of 4 | Solid Edge
Program: Computer-Aided Design (CECCC) - Metropolitan Community College - Acalog ACMS™
Relevance of AI in computer-aided design | Software Solutions Studio
CADD Lab - Mechanical Engineering Program | Montana State University
4 Ways to Draw Folds & Ruffles in Computer-Aided Fashion Design
"CE 101-L67: Civil Engineering Computer Aided Design" by Stephanie Santos
anna university me computer aided design syllabus
Computer-aided Design of Electrical Machines (Vishnu Murthy, K. M.) - HandoutsEt
2010 Research Report | Ohio Supercomputer Center
CAADbiwak - Colloquium (Image 2058) // RWTH // Computer Aided Architectural Design / GRAFT // Aachen // Photography Aryan...
New Collaborative Research Paper Published in Journal of Computer-Aided Molecular Design (IF 4.179) - BioSIM
Wear behavior of current computer-aided design and computer-aided manufacturing composites and reinforced high performance...
Drafting5
- Computer Aided Design (CAD) is a type of computer-based tool used for drafting and designing. (break2up.com)
- This software has all built in features as per users need and come with many templates and symbols, for designing and drafting purposes, which gives it a wide area of application. (break2up.com)
- This career certificate provides career preparation in engineering drafting and design practices. (mccneb.edu)
- Recipients may seek employment in engineering drafting and design entry-level positions in engineering, architecture and design firms, and government agencies. (mccneb.edu)
- Speeding up drafting and selecting design options by generating suggestions based on certain parameters (such as weight, size, costs, or material). (softwaresim.com)
Architectural Design1
- The HND Computer Aided Architectural Design and Technology course offers a unique approach to architectural studies - focusing on the use of CAD and other digital technologies in construction with an emphasis on the role of the Architectural Technologist (AT). (planitplus.net)
Graft5
- Computational analyses and design improvements of graft-to-vein anastomoses. (ncsu.edu)
- The idea is to geometrically design graft-to-vein configurations such that aggravating flow patterns are reduced, and hence stenotic developments are minimized. (ncsu.edu)
- Focusing on a new blood rheological model in conjunction with three graft-to-vein anastomotic configurations, that is, a base case, the Bard-IMPRA Venaflo graft, and a new graft-end design, the corresponding transient laminar 3-D hemodynamics are numerically simulated and compared. (ncsu.edu)
- As a result of this comparison study, quantitative recommendations for arteriovenous loop graft designs toward increased patency rates are provided. (ncsu.edu)
- The resulting improved graft design will be scrutinized in clinical trials. (ncsu.edu)
Composites2
- Wear behavior of current computer-aided design and computer-aided manufacturing composites and reinforced high performance polymers: An in vitro study. (bvsalud.org)
- To analyze the wear rate of computer-aided design and computer-aided manufacturing (CAD/CAM) composites, polyetheretherketones and glass ceramics . (bvsalud.org)
Maintainability design2
World Health Organ1
- A review of studies which have used quantitative methods to evaluate the effectiveness of interventions and programmes implemented to prevent and control AIDS / Dominique Hausser, Fred Paccaud in collaboration with Global Programme on AIDS, World Health Organization, Geneva, Switzerland. (who.int)
Innovations1
- This research may address the use of new materials, better fabrication techniques or design innovations, use of emerging technologies, analysis of competitor products, and similar topics. (cdc.gov)
Molecular4
- Diseño molecular de fármacos con propósitos específicos (unión al ADN, inhibición enzimática, eficacia contra el cáncer, etc.) basado en el conocimiento de propiedades moleculares tales como la actividad de los grupos funcionales, la geometría molecular y la estructura electrónica, así como en la información catalogada sobre fármacos análogos. (bvsalud.org)
- El diseño de fármacos generalmente consiste en el modelado molecular asistido por ordenador y no comprende la FARMACOCINÉTICA, el análisis de las dosis ni el análisis de la administración del fármaco. (bvsalud.org)
- The molecular designing of drugs for specific purposes (such as DNA -binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. (bvsalud.org)
- Drug design is generally computer-assisted molecular modeling and does not include PHARMACOKINETICS , dosage analysis, or drug administration analysis. (bvsalud.org)
Conceptual design7
- It is useful in engineering processes in conceptual design, and laying out and analyzing components in manufacturing methods. (break2up.com)
- During Conceptual Design, the initial concept for the new machine or system is defined. (cdc.gov)
- The needs defined during this period provide the foundation for the conceptual design of the new machine. (cdc.gov)
- During the Conceptual Design Phase, designers may initiate focused research efforts to identify ways to reduce costs, improve the design, or enhance productivity. (cdc.gov)
- When needs have been defined and initial research completed, an early conceptual design of the machine is developed. (cdc.gov)
- The conceptual design step output may take the form of a series of functional specifications along with a description of the machine. (cdc.gov)
- The conceptual design and related supporting materials will often serve as the basis for project go/no-go decisions. (cdc.gov)
Chapter1
- This chapter provides a step‐by‐step guide and research evidence on all computer‐aided design ( CAD ) procedures involved in digital workflows in dentistry, from setting up digital imaging methods to work with digital design and treatment planning. (pocketdentistry.com)
Program5
- Completion of the program will give students the skills required for entry-level positions as a draftsperson in organizations that include mechanical and design areas. (conestogac.on.ca)
- The Ontario Student Assistance Program (OSAP) is a needs-based program designed to help Ontario students cover the cost of post-secondary education. (conestogac.on.ca)
- This post on the Wolfram blog about using Mathematica to play around with logo designs provides a tantalzing glimpse into how useful the program could be as a graphic design tool. (kottke.org)
- Appendix A: Installation, describes how to load and run this program on your computer. (cdc.gov)
- CAL is the University of Pennsylvania School of Veterinary Medicine's Computer Aided Learning program. (bvsalud.org)
Curriculum1
- CAL projects are designed to supplement the veterinary curriculum offered by the School and provi. (bvsalud.org)
Mechanical design1
- We wanted a purely mechanical design to be available to the world as a Plan B Ventilator - ultimately decisions will be taken by local clinicians as to the manner in which it is used and modified," says, Dr. Prashant Jha. (iiserpune.ac.in)
Essentially1
- By no longer adhering to outdated design paradigms, researchers said, the possibilities are essentially endless. (llnl.gov)
Analysis3
- Section 1, AIDS Surveillance in the United States , describes the data collection process and the effect changes in this process may have on data analysis and interpretation. (cdc.gov)
- 1980. Gas chromatography mass spectrometry computer analysis of volatile halogenated hydrocarbons in man and his environment- A multimedia environmental study. (cdc.gov)
- The U.S. Bureau of Mines has developed an easy to use personal computer-based software package to aid in the analysis of the visibility and illumination aspects of mining equipment design. (cdc.gov)
Simulations2
- The emergence of additive manufacturing (3D printing) and powerful multi-physics computer simulations have enabled design to reach unprecedented levels of complexity, expanding the realm of what can be engineered and created. (llnl.gov)
- It may surprise some people but engineers are still doing things by trial and error -- even if they are doing simulations, it is still trial and error," said Computational Design Optimization project co-lead Dan White. (llnl.gov)
Technology4
- Computer-aided design or CAD programs are utilized in just about every business today to keep a company on the cutting edge of technology. (conestogac.on.ca)
- The impact of the technology of Computer-Aided Design and Manufacturing in automobile engineering, marine engineering and aerospace engineering has been tremendous. (phindia.com)
- CAD is an automated method of combining computer technology and specialized software. (softwaresim.com)
- The Mechanical Engineering / Mechanical Engineering Technology CADD lab provides a modern facility for instruction in a variety of computer software packages. (montana.edu)
Tools5
- However, conventional design tools such as computer-aided design (CAD) and computer-aided engineering (CAE) have not caught up to advanced manufacturing technologies and the sheer number of design possibilities they afford. (llnl.gov)
- In this field, it is used for designing various machinery and tools that are useful for manufacturing purposes. (break2up.com)
- In Chapters 9 these tools will be used to analyze and select materials to design for the environment. (jfjm100.com)
- Once you know how to begin as a digital artist, it will be easier to draw folds and ruffles on software designing tools. (hunarcourses.com)
- The purpose of this project was to develop a representative, scalable hand model to be used with 3-D software drawing packages to aid in the ergonom ic design of hand tools. (cdc.gov)
Search1
- Results of search for 'au:'WHO Global Programme on AIDS. (who.int)
Current1
- These modifications could make the current design more usable. (iiserpune.ac.in)
Research4
- With Laboratory Directed Research and Development ( LDRD ) strategic initiative (SI) funding, the center began a new Computational Design Optimization strategic initiative, including collaborators at University of Illinois at Urbana-Champaign, Lund University, University of Wisconsin Madison, and Technical University in Denmark. (llnl.gov)
- Fundamentally changing the way design is done is really what we want to do," said Rob Sharpe, deputy associate director for research and development within Engineering . (llnl.gov)
- Fundamental research in chemistry has laid the foundations for the discovery and design of new materials with fascinating magnetic, electrical and optical properties, prompting inventions anywhere from faster computers to lighter long-range planes. (osc.edu)
- The application of this research includes improved ergonom ic hand tool design through the use of hand anthropometry reference values developed from the general population using grasping hand postures. (cdc.gov)
Scope1
- Computer Fashion Design gives you the scope of practical knowledge of fabric designing. (hunarcourses.com)
Requirements3
- Designers typically need to tune model parameters manually to develop the best design for a project's requirements. (softwaresim.com)
- Regulatory requirements also have had to be incorporated into the design, further adding to the machine's complexity. (cdc.gov)
- Under the Systems Approach to Design, efforts are made to identify all user needs and requirements, equipment performance specifications, regulatory constraints, market conditions, and other factors impacting the system's performance before the formal design process is initiated. (cdc.gov)
Description1
- Designed as a textbook for the undergraduate students of mechanical engineering, production engineering and industrial engineering, it provides a description of both the hardware and software of CAD/CAM systems. (phindia.com)
Engineers3
- Through the SI, researchers want to have computers do the repetitive work, freeing up engineers to focus their attention on more creative matters. (llnl.gov)
- To optimize design for those printers, engineers will need the same level of resolution in their design software, White said, a feat only possible through high-performance computing. (llnl.gov)
- It is useful for engineers, architects, and other designing professions. (break2up.com)
Software Applications3
- In the field of electronics, it is used in manufacturing process planning, digital circuit design, and other software applications. (break2up.com)
- Computer Aided Software Applications are now available on personal computers to facilitate users to work from home. (break2up.com)
- This heavily used instructional laboratory supplements the adjacent Design Lab which shares nearly all software applications. (montana.edu)
Drug1
- The study also discusses natural and synthetic indole-containing compounds with anti-SARS-CoV-2 properties, as well as computer-aided drug design (in-silico studies) for optimizing anti-SARS-CoV-2 hits/leads. (bvsalud.org)
Analyze1
- It also suggests computer hardware and software you can use to analyze the data. (cdc.gov)
Complexity2
- However, supply chain disruption (including export bans) as well as the cost and complexity of most ventilator designs pose significant challenges during the ongoing pandemic. (iiserpune.ac.in)
- Today, computer-aided design is on the verge of another revolution, with the primary driver being artificial intelligence (AI) and machine learning (ML). Famously considered a "black-box" industry due to its technical complexity, artificial intelligence hasn't been fully accepted or comprehended by the majority of the populace in most countries just yet. (softwaresim.com)
Rely2
- It can also be operated manually in the event of power failure and, unlike many designs, does not rely on pressurized piped oxygen or air. (iiserpune.ac.in)
- Individuals with lesser insights into how computer programming works appear to rely less upon the validity of AI outcomes, specifically ADMs. (softwaresim.com)
Approach3
- To cope with the mounting sophistication, many designers and manufacturers have turned to the "Systems Approach" for designing new hardware. (cdc.gov)
- Described below is an overview of one notion to the systems approach to design and how human factors engineering fits into it. (cdc.gov)
- The chart below illustrates one method of the Systems Approach to Design. (cdc.gov)
Year1
- Year 2 projects center around the design and construction of commercial projects, with the end of year project and showcase giving you the opportunity to design for a client and present your project along with your peers. (planitplus.net)
Enhance1
- How can artificial intelligence enhance computer-aided design? (softwaresim.com)
Systems2
- The modelling procedures outlined in this paper provide a precise and efficient way of designing active suspension systems that minimizes a necessary tuning process. (ncsu.edu)
- Computer controlled systems in many machines have advantages of limiting operational exposure but impose machine hazards such as operators getting caught in machinery during programming and code testing phases. (cdc.gov)
Learning1
- This tutorial is part of an ongoing project designed to implement multimedia and computer-based learning materials in the university undergraduate classroom. (bvsalud.org)
Work2
- We want to be able to design things that are so complicated that human intuition isn't going to work…Almost all design work has been done for things that are static. (llnl.gov)
- It enables them to design buildings in 2D and 3D models to give almost a real replica of the original work. (break2up.com)
Process3
Underground mining eq1
- The design of underground mining equipment was analyzed with respect to ease of maintenance and maintainer safety. (cdc.gov)
Courses1
- Check out CAD Fashion Design Courses online with which you can learn to design your own garments digitally. (hunarcourses.com)
Materials2
Types1
- In the field of architecture, it is used as an effective tool for designing all types of buildings and assessing the integrity of steel-framed buildings. (break2up.com)
Project1
- Changing a single parameter can substantially impact the properties of a design, so validating designs after each change can extend the project by days or even weeks . (softwaresim.com)
Parameters1
- Although optimization has been around since the 1980s, Tortorelli said, it has been largely limited to linear elastic design problems and is often performed through trial and error, looping a simulation over and over with different parameters until reaching a functional design. (llnl.gov)
Collaboration1
- étude effectuée en collaboration avec l' Unité sexualité et planification familiale et le Programme régional de lutte contre le SIDA de l' Organisation mondiale de la Santé. (who.int)
Costs2
- Using computers in manufacturing is receiving particular prominence as industries seek to improve product quality, increase productivity and to reduce inventory costs. (phindia.com)
- Lower product development costs and reduced design cycles are some other attributes of the CAD software. (break2up.com)
Popular1
- These popular CAD programs are being used in the manufacturing, design, and architectural areas. (conestogac.on.ca)
Simple2
- Speaking on the versatility of the design, Dr. Umakant D. Rapol said that the mechanics of the design is fairly simple and allows mass-production. (iiserpune.ac.in)
- Designing starts with simple shapes and easy-to-create ideas. (hunarcourses.com)
Technological2
- To address next-generation technological capabilities and their potential impact, Lawrence Livermore National Laboratory instituted the Center for Design and Optimization last October, tasked with using advanced manufacturing techniques, high-performance computing and cutting-edge simulation codes to optimize design. (llnl.gov)
- Many educational institutions are nowadays indulging in teaching CAD to their students to make them aware of the latest technological advancement in the field of designing. (break2up.com)
Human1
- When it comes to designing fabric digitally, one of the first things you need to consider is how they look on the human body. (hunarcourses.com)
Start4
- When you are designing, it is best to start with basic symmetrical shapes and designs. (hunarcourses.com)
- Even if the design is not symmetrical, you need to give it a start unless you excel at it. (hunarcourses.com)
- These will help you when you start designing. (hunarcourses.com)
- You can start by designing the shape. (hunarcourses.com)