Composite Tissue Allografts: A graft consisting of multiple tissues, such as muscle, bone, nerve, vasculature, and skin, comprising a functional unit for reconstructive purposes.Hand Transplantation: The transference of a complete HAND, as a composite of many tissue types, from one individual to another.Facial Transplantation: The transference between individuals of the entire face or major facial structures. In addition to the skin and cartilaginous tissue (CARTILAGE), it may include muscle and bone as well.Tissue Transplantation: Transference of tissue within an individual, between individuals of the same species, or between individuals of different species.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Transplantation Tolerance: An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.Surgical Flaps: Tongues of skin and subcutaneous tissue, sometimes including muscle, cut away from the underlying parts but often still attached at one end. They retain their own microvasculature which is also transferred to the new site. They are often used in plastic surgery for filling a defect in a neighboring region.Rats, Inbred WFVascularized Composite Allotransplantation: Transference of multiple tissues, such as muscle, bone, nerve, and skin, as a functional unit for reconstructive purposes. Blood supply to the transplanted tissues is maintained throughout the transplantation procedure with minimal ischemia. Maintenance of vascularity in the graft promotes its viability, function, and survival in the recipient.Skin Transplantation: The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.Rectus Abdominis: A long flat muscle that extends along the whole length of both sides of the abdomen. It flexes the vertebral column, particularly the lumbar portion; it also tenses the anterior abdominal wall and assists in compressing the abdominal contents. It is frequently the site of hematomas. In reconstructive surgery it is often used for the creation of myocutaneous flaps. (From Gray's Anatomy, 30th American ed, p491)Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Composite Resins: Synthetic resins, containing an inert filler, that are widely used in dentistry.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Laser Capture Microdissection: Techniques using a laser to cut away and harvest a specific cell or cluster of cells from a tissue section while viewing it under the microscope.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)New Zealand: A group of islands in the southwest Pacific. Its capital is Wellington. It was discovered by the Dutch explorer Abel Tasman in 1642 and circumnavigated by Cook in 1769. Colonized in 1840 by the New Zealand Company, it became a British crown colony in 1840 until 1907 when colonial status was terminated. New Zealand is a partly anglicized form of the original Dutch name Nieuw Zeeland, new sea land, possibly with reference to the Dutch province of Zeeland. (From Webster's New Geographical Dictionary, 1988, p842 & Room, Brewer's Dictionary of Names, 1992, p378)KentuckyEcuadorSamoa: A group of islands in the southwest central Pacific, divided into AMERICAN SAMOA and the INDEPENDENT STATE OF SAMOA (Western Samoa). First European contact was made in 1722 by Jacob Roggeveen, a Dutchman. In 1768 they were named Navigators Islands by Louis de Bougainville. The present name may derive from that of a local chieftain or from a local word meaning place of the moa, a now-extinct island bird. (From Webster's New Geographical Dictionary, 1988, p1061 & Room, Brewer's Dictionary of Names, 1992, p481)Hand: The distal part of the arm beyond the wrist in humans and primates, that includes the palm, fingers, and thumb.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Tissue Scaffolds: Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Tissue Embedding: The technique of placing cells or tissue in a supporting medium so that thin sections can be cut using a microtome. The medium can be paraffin wax (PARAFFIN EMBEDDING) or plastics (PLASTIC EMBEDDING) such as epoxy resins.Bone Transplantation: The grafting of bone from a donor site to a recipient site.Bone Demineralization Technique: Removal of mineral constituents or salts from bone or bone tissue. Demineralization is used as a method of studying bone strength and bone chemistry.Clove Oil: An oil from flower buds of SYZYGIUM trees which contains large amounts of EUGENOL.Surgery, Plastic: The branch of surgery concerned with restoration, reconstruction, or improvement of defective, damaged, or missing structures.Plastics: Polymeric materials (usually organic) of large molecular weight which can be shaped by flow. Plastic usually refers to the final product with fillers, plasticizers, pigments, and stabilizers included (versus the resin, the homogeneous polymeric starting material). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Dental Articulators: Mechanical devices that simulate the temporomandibular joints and jaws to which maxillary and mandibular casts are attached. The entire assembly attempts to reproduce the movements of the mandible and the various tooth-to-tooth relationships that accompany those movements.Reconstructive Surgical Procedures: Procedures used to reconstruct, restore, or improve defective, damaged, or missing structures.Cosmetics: Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)Osteotomy, Le Fort: Transverse sectioning and repositioning of the maxilla. There are three types: Le Fort I osteotomy for maxillary advancement or the treatment of maxillary fractures; Le Fort II osteotomy for the treatment of maxillary fractures; Le Fort III osteotomy for the treatment of maxillary fractures with fracture of one or more facial bones. Le Fort III is often used also to correct craniofacial dysostosis and related facial abnormalities. (From Dorland, 28th ed, p1203 & p662)Creativity: The ability to generate new ideas or images.Tissue Expansion: A procedure whereby the body is stimulated to generate extra soft tissue by the application of stretching forces that stimulate new growth of tissue which, over a period of time, results in a 2-dimensional expansion of the tissue. The procedure is used in reconstructive surgery for injuries caused by trauma, burns, or ablative surgery. Various types of TISSUE EXPANSION DEVICES have been developed that exert stretching forces.Free Tissue Flaps: A mass of tissue that has been cut away from its surrounding areas to be used in TISSUE TRANSPLANTATION.ArtHumerus: Bone in humans and primates extending from the SHOULDER JOINT to the ELBOW JOINT.Shoulder Fractures: Fractures of the proximal humerus, including the head, anatomic and surgical necks, and tuberosities.Shoulder Joint: The articulation between the head of the HUMERUS and the glenoid cavity of the SCAPULA.Shoulder: Part of the body in humans and primates where the arms connect to the trunk. The shoulder has five joints; ACROMIOCLAVICULAR joint, CORACOCLAVICULAR joint, GLENOHUMERAL joint, scapulathoracic joint, and STERNOCLAVICULAR joint.Mathematical Concepts: Numeric or quantitative entities, descriptions, properties, relationships, operations, and events.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Shoulder Pain: Unilateral or bilateral pain of the shoulder. It is often caused by physical activities such as work or sports participation, but may also be pathologic in origin.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.

The effect of postoperative corticosteroid administration on free vascularized fibular grafting for treating osteonecrosis of the femoral head. (1/1)

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Fig. 27. Destruction of the underlying white matter (arrows) allows graft efferents to invade the hippocampus (B-3.6). Darkfield microscopy. Cx, host cortex; DG, dentate gyrus; Hip, hippocampus; Tr, transplant; Sub, subiculum; w.m., white matter. Neurite growth inhibition by myelin is currently (but not exclusively; Raisman, 2004) explained by interactions between myelin-related inhibitory factors (Nogo-A protein; myelin-associated glycoprotein, MAG; and oligodendrocytes-myelin glycoprotein, OMgp) and a common neuronal Nogo receptor (Fournier et al., 2001; McGee and Strittmatter, 2003; Filbin, 2004). Whether such inhibitory interactions make for graft axon repulsion in graft situations is debatable, in part because the neuronal Nogo receptor seems barely detectable in the normal brain at least till the end of the first postnatal week (Wang et al., 2002). The implication is that graft axons would be able to navigate for some two weeks in white matter tracts before being stopped by inhibitory ...
MiMedx Group, Inc. (NASDAQ: MDXG), the leading biopharmaceutical company developing and marketing regenerative and therapeutic biologics utilizing human placental tissue allografts
WebDentistry offers a weatlth of information about dentistry including a dentists directory with more than 180,000 listings, detailed credential reports, articles for dental patients and providers, consumer advice, and dental bookstore.
Composite tissue allotransplantation has been recently introduced as a potential clinical treatment for complex reconstructive procedures, include traumatic injuries, cancer ablative surgeries, or extensive tissue loss secondary to burns. Composite tissue allografts (CTAs) consist of heterogeneous tissues derived from ectoderm and mesoderm, including skin, fat, muscle, nerves, lymph nodes, bone, cartilage, ligaments, and bone marrow, with different antigenicity. Thus, composite tissue structure is considered to be more immunogenic than solid organ transplants. While cartilage, ligaments, and fat present low antigenicity, bone, muscles, nerves, and vessels present moderate antigenicity, and skin is the component that develops the most severe rejection because of the abundance of dendritic cells within the epidermis and dermis. To study the mechanisms of CTA acceptance and rejection, different experimental models, strategies and different immunosuppressive protocols have used [1, 2]. ...
Stem Cell Recruitment™(SCR), Stem Cell Recruitment Therapy™(SCRT), SCR Facial™ and Vivaderm™ are trademarks of Russell Health, Inc. The treatments described on this marketing are not considered to be standard of care for any condition or disease. SCR, SCRT, SCR Facial and Vivaderm™ attempt to utilize acellular, minimally manipulated tissue allografts and are comprised of tissue allograft components intended for homologous use to supplement tissue. SCRT products are classified by the Food and Drug Administration (FDA) as Human Cell, Tissue and Cellular and Tissue-Based Products (HCT/P) that are regulated solely under section 361 of the Public Health Service (PHS) Act. FDA recognizes that human tissue was designed, or evolved, to perform certain functions in the human body with exquisite safety and effectiveness. As an HCT/P regulated solely under Section 361 of the PHS Act, Russell Healths SCRT products are exempt from FDA pre-market review, clearance, and approval from FDA. Please ...
Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. Normally the immune system reacts to foreign antigens that are associated with exogenous or endogenous Danger signals, which triggers a proliferation of antigen-specific CD8+ T cells and/or CD4+ helper cells. The binding of PD-L1 to PD-1 or B7.1 transmits an inhibitory signal that reduces the proliferation of these T cells and can also induce apoptosis, which is further mediated by a lower regulation of the gene Bcl-2. PD-L1 was characterized at the Mayo Clinic as an immune regulatory molecule, B7-H1. Later this molecule was renamed as PD-L1 because it was ...
Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research, videos and posters.
An uncommon condition means Zach Tahir is prone to eat everything from wall plaster to window blinds. So for his birthday, the boy got quite the gift -- an
At Erasmus, our vision is to become the leading Professional Congress Organiser in Greece and one of the top ten Professional Congress Organisers globally, while conducting our business with professionalism, ethics and responsibility towards our people (personnel), our clients and the society ...
Composite tissue allotransplantation is a rapidly developing field in plastic and reconstructive surgery and therefore imposes an obligation upon plastic and transplant surgeons to familiarize themselves with some unique ...
The administration of glucocorticosteroids results in a wide range of effects on inflammatory and immunologically mediated disease processes. Glucocorticosteroids cause neutrophilic leukocytosis together with eosinopenia, monocytopenia, and lymphocytopenia. A principal mechanism whereby corticosteroids suppress inflammation is their impeding the access of neutrophils and monocytes to an inflammatory site. Granulocyte function is relatively refractory, whereas monocyte-macrophage function seems to be particularly sensitive to corticosteroids. Corticosteroid administration causes a transient lymphocytopenia of all detectable lymphocyte subpopulations, particularly the recirculating thymus-derived lymphocyte. The mechanism of this lymphocytopenia is probably a redistribution of circulating cells to other body compartments. There is considerable disagreement about the direct effects of corticosteroid administration on human lymphocyte function. The corticosteroid regimen should be adjusted to attain ...
The chemical synthesis of naturally occurring corticosteroids has led to the generation of artificial corticosteroids that are used in therapeutic veterinary drugs. Many of these drugs are also used illegally as growth promoters particularly in cattle, often in combination with J-agonists. Dexamethasone, Flumethasone and Betamethasone all belong to this group of drugs that are also known as glucocorticosteriods. The European Union has banned the use of corticosteroids administration for fattening purposes in animals.. The Randox Food Diagnostics Corticosteroids ELISA test kit offers excellent limits of detection for the screening of growth promoter residues across a range of food and veterinary matrices.. ...
2008). "Hand Transplantation: The Innsbruck Experience". Transplantation of Composite Tissue Allografts. pp. 234-250. doi: ... July 2007). "Second report (1998-2006) of the International Registry of Hand and Composite Tissue Transplantation". Transpl ... 1998). "The case for local immunosuppression in composite tissue allotransplantation". Transplantation Proceedings. 30 (6): ... "UCLA Hand Transplant Program - Composite Tissue Allotransplantation , UCLA Transplantation Services - Los Angeles, CA". ...
... regulated and American Association of Tissue Banks-accredited tissue banks distribute 1.5 million bone and tissue allografts. A ... These grafts persist however as homostatic grafts and are completely replaced by host tissues in time.) "Composite Tissue ... Most human tissue and organ transplants are allografts. It is contrasted with autotransplantation (from one part of the body to ... In the US, donor tissue must be harvested and processed adhering to the Current Good Tissue Practices rule. In most cases it is ...
... regulated and American Association of Tissue Banks-accredited tissue banks distribute 1.5 million bone and tissue allografts. ... "Composite Tissue Allotransplantation and Reconstructive Surgery". US National Library of Medincine. PMC 1513974.. Missing or ... Transplantable organs and tissues[edit]. Main article: Transplantable organs and tissues. A variety of organs and tissues can ... Most human tissue and organ transplants are allografts. It is contrasted with autotransplantation (from one part of the body to ...
Alloprosthetic composites are a combination of multiple limb-sparing techniques. Allografts are used to replace the bone that ... It literally means "surgical repair of joint.' In the past, arthroplasty used tissue and removal of bone to relieve pain. ... Prosthesis is then used to support and strengthen the allografts. Alloprosthetic composites are flexible in that surgeons can ... This is accomplished through the use of Allografts and Autografts. Allografts are done by creating bone grafts from a donor ...
Such tissues are called mineralized tissues. It is an extremely widespread phenomenon; all six taxonomic kingdoms contain ... A biomaterial may also be an autograft, allograft or xenograft used as a transplant material. Biomineralization is the process ... ceramics or composite materials. They are often used and/or adapted for a medical application, and thus comprises whole or part ... The mesh allows for the body's tissue to grow while incorporating the valve. Most of the time, 'artificial' tissue is grown ...
Composite graft A composite graft is a small graft containing skin and underlying cartilage or other tissue. Donor sites ... allograft). Xenogeneic: The donor and recipient are of different species (e.g., bovine cartilage; xenograft or heterograft). ... The transplanted tissue is called a skin graft. Skin grafting is often used to treat: Extensive wounding or trauma Burns Areas ... For more extensive tissue loss, a full-thickness skin graft, which includes the entire thickness of the skin, may be necessary ...
Bone is a very complex tissue: strong, elastic, and self-repairing. Damaged bone can be replaced with bone from other parts of ... Research at the Lawrence Berkeley National Laboratory has resulted in a metal-ceramic composite that has, like bone, a fine ... the body (autografts), from cadavers (allograft), or with various ceramics or metallic alloys. The use of autografts limits how ... The substitute bone has a porous structure permitting blood vessels and other accessory tissues to penetrate it, allowing ...
Abdeen A, Healey JH (September 2010). "Allograft-prosthesis composite reconstruction of the proximal part of the humerus: ... Bone and Soft Tissue Tumors About the Knee. The Adult Knee. Editors: J.J. Callaghan, A.G. Rosenberg, H.E. Rubash, P.T. Simion, ... Soft Tissue, Sarcoma and Bone Tumors. Townsend: Sabiston Textbook of Surgery, 16/E. Philadelphia, W.B. Saunders 2000:511-532. ... October 2011). "Evaluation of eIF4E expression in an osteosarcoma-specific tissue microarray". J. Pediatr. Hematol. Oncol. 33 ( ...
Aluminum, titanium, composite materials Aircraft jet engines Synthetic diamond early uses (drill bits, jewelry) Silicon ... A biomaterial may also be an autograft, allograft or xenograft used as an organ transplant material. ... Biomaterials science encompasses elements of medicine, biology, chemistry, tissue engineering, and materials science. ... Mathews, F.L. & Rawlings, R.D. (1999). Composite Materials: Engineering and Science. Boca Raton: CRC Press. ISBN 978-0-8493- ...
Tan W, Krishnaraj R, Desai TA (April 2001). "Evaluation of nanostructured composite collagen--chitosan matrices for tissue ... now forms the phase I/II of clinical trials involving implantation of islet allografts into the subcutaneous site. However, ... Thus, Type-I collagen obtained from animal tissues is now successfully being used commercially as tissue engineered biomaterial ... and easy processability make this polymer a good choice for tissue engineering applications. It is used in engineering tissues ...
Aluminum, titanium, composite materials Aircraft jet engines Synthetic diamond early uses (drill bits, jewelry) Silicon ... A biomaterial may also be an autograft, allograft or xenograft used as an organ transplant material. ... Biomaterials science encompasses elements of medicine, biology, chemistry, tissue engineering, and materials science. ... Mathews, F.L. & Rawlings, R.D. (1999). Composite Materials: Engineering and Science. Boca Raton: CRC Press. ISBN 978-0-8493- ...
2008). "Hand Transplantation: The Innsbruck Experience". Transplantation of Composite Tissue Allografts. pp. 234-250. doi: ... July 2007). "Second report (1998-2006) of the International Registry of Hand and Composite Tissue Transplantation". Transpl ... 1998). "The case for local immunosuppression in composite tissue allotransplantation". Transplantation Proceedings. 30 (6): ... "UCLA Hand Transplant Program - Composite Tissue Allotransplantation , UCLA Transplantation Services - Los Angeles, CA". ...
Vascularized Composite Allotransplantations (VCA) have become a clinical reality. However, broad clinical application of VCA is ... Ustüner, E. T., Zdichavsky, M., Ren, X., et al. Long-term composite tissue allograft survival in a porcine model with ... Hettiaratchy, S., Mendely, E., Randolph, M. A., et al. Tolerance to composite tissue allografts across a major ... Mathes, D. W., Randolph, M. A., Solari, M. G., et al. Split tolerance to a composite tissue allotransplant in a swine model. ...
Locally Implantable Biodegradable Polymeric Tacrolimus Disc Prolongs Survival of Vascularized Composite Allografts without ... TAC levels in blood and tissues were measured using LC-MS/MS. In addition to allograft survival, systemic toxicity was ... Locally Implantable Biodegradable Polymeric Tacrolimus Disc Prolongs Survival of Vascularized Composite Allografts without ... Widespread application of Vascularized Composite Allografts (VCA) has been limited due to systemic side effects associated with ...
Topical Immunotherapy Synergizes with Systemic Immunotherapy to Prolong Survival of Vascularized Composite Allografts without ... Tissue biopsies were collected for drug levels measurement, cytokines analysis, and histopathology. In addition to allograft ... Topical Immunotherapy Synergizes with Systemic Immunotherapy to Prolong Survival of Vascularized Composite Allografts without ... Vascularized Composite Allografts (VCA) provides a unique opportunity for the local delivery of the drugs directly to the graft ...
... treatment reduced expression of inflammatory mediators and enhanced expression of Treg-associated cytokines in allograft tissue ... For individuals who sustain devastating composite tissue loss, vascularized composite allotransplantation (VCA; e.g., hand and ... Vascularized composite allotransplantation (VCA) is an emerging field that is particularly beneficial for select amputees and ... In a rat hindlimb VCA model, local administration of this Treg-inducing system, referred to as TRI-MP, prolonged allograft ...
... or extensive tissue loss secondary to burns. Composite tissue allografts (CTAs) consist of heterogeneous tissues derived from ... Black KS, Hewitt CW, Fraser LA et al (1985) Composite tissue (limb) allografts in rats. II. Indefinite survival using low-dose ... Hewitt CW, Black KS, Fraser LA et al (1985) Composite tissue (limb) allografts in rats. I. Dose-dependent increase in survival ... Jones JW Jr, Ustuner ET, Zdichavsky M et al (1999) Long-term survival of an extremity composite tissue allograft with FK506- ...
Composite tissue allotransplantation has been recently introduced as a potential clinical treatment for complex reconstructive ... or extensive tissue loss secondary to burns. Composite tissue allografts (CTAs) consist of heterogeneous tissues derived from ... Black KS, Hewitt CW, Fraser LA et al (1985) Composite tissue (limb) allografts in rats. II. Indefinite survival using low-dose ... Hewitt CW, Black KS, Fraser LA et al (1985) Composite tissue (limb) allografts in rats. I. Dose-dependent increase in survival ...
These results suggest that humoral rejection occurs rarely, if at all, in the setting of human composite tissue allografts. ... We investigated whether C4d deposition also would be useful in monitoring rejection in human composite tissue allografts. A ... Absence of C4d Deposition in Human Composite Tissue (Hands and Face) Allograft Biopsies: An Immunoperoxidase Study. ... paraffin-embedded and four frozen biopsy specimens from four patients with composite tissue allografts (three hands, one face) ...
TISSUE PRESERVATION / 組織保存. Research Abstract. For the clinical application of composite tissue allograft, we have done the ... Publications] Kuroki H,Ikuta Y,Masuda Y: Experimenta Studies of Rat Composite Tissue (Limb) Allograft. J.Jpn. Soc. Surg. Hand ... After that, these results will be evaluated and we will esatbish the transplantation immunity for composite tissue allograft. ... EXPERIMENTAL STUDY ABOUT THE INDUCTION AND MAINTENANCE OF IMMUNOLOGIC TOLERANCE FOR THE COMPOSITE TISSUE ALLOGRAFT. Research ...
The allograft is prepared by treating a section of cadaver bone to remove all soft tissue, then texturing the bone surface to ... Compound bone structure fabricated from allograft tissue. WO2000040177A1 *. Dec 18, 1999. Jul 13, 2000. Lifenet. Composite bone ... The allograft is prepared by treating a section of cadaver bone to remove all soft tissue, then texturing the bone surface to ... The allograft is prepared by treating a section of cadaver bone to remove all soft tissue, then texturing the bone surface to ...
... regulated and American Association of Tissue Banks-accredited tissue banks distribute 1.5 million bone and tissue allografts. ... "Composite Tissue Allotransplantation and Reconstructive Surgery". US National Library of Medincine. PMC 1513974.. Missing or ... Transplantable organs and tissues[edit]. Main article: Transplantable organs and tissues. A variety of organs and tissues can ... Most human tissue and organ transplants are allografts. It is contrasted with autotransplantation (from one part of the body to ...
Tolerance and Future Directions for Composite Tissue Allograft Transplants: Part II. Siemionow, Maria; Klimczak, Aleksandra ... Use of Vascularized Periosteum or Bone to Improve Healing of Segmental Allografts after Tumor Resection: An Ovine Rib Model. ... Master Techniques in Orthopaedic Surgery: Soft Tissue Surgery, 1st Ed.. Hoxworth, Ronald E. ... Keeping Options Open for Patients with Anticipated Postmastectomy Chest Wall Irradiation: Immediate Tissue Expansion Followed ...
Ethical considerations in the early composite tissue allograft experience: a review of the Louisville Ethics Program. ... The Evolution of Composite Tissue Allotransplantation: the Twentieth Century Realization of. Charles W. Hewitt, W. P. Andrew ... Composite tissue allotransplantation: classification of clinical acute skin rejection. Transplantation. 2006 Feb 15. 81(3):418- ... Achievements and challenges in composite tissue allotransplantation. Transpl Int. 2011 Aug. 24 (8):760-9. [Medline]. [Full Text ...
We plan to carry out allograft composite tissue transplantation after a careful systemic preparation. ... In recent years, with the progress in composite tissue allotransplantation, there comes a new hope for the severely disfigured ... Progress in composite tissue allotransplantation provides a new remedy for severely disfigured patients. ... Traditional reconstructive procedures include free skin graft, application of local flaps, tissue prefabrication, tissue ...
As A Single-Dose Stem Cell Mobilizing Agent In Vascularized Composite Tissue Allograft (VCA) Transplantation In A Canine Model ... AMD3100 (Plerixafor) As A Single-Dose Stem Cell Mobilizing Agent In Vascularized Composite Tissue Allograft (VCA) ... Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by toxicities of chronic ...
functioning allograft. *document and manage complications associated with Composite Tissue allotransplantation. 20. All. 18 ... Vascularized Composite Allotransplantation of the Hand. *Upper Extremity Injuries. *Procedure: Allogeneic hand transplantation ...
Split tolerance to a composite tissue allograft in a swine model.. Mathes DW, Randolph MA, Solari MG, Nazzal JA, Nielsen GP, ... A modified model of hindlimb osteomyocutaneous flap for the study of tolerance to composite tissue allografts. ... influence of allograft mass and vascularized bone marrow content on vascularized composite allograft survival. ... Vascularized composite allograft transplant survival in miniature swine: is MHC tolerance sufficient for acceptance of ...
In: Hewitt C.W., Lee W.P.A., Gordon C.R. (eds) Transplantation of Composite Tissue Allografts. Springer, Boston, MA. * DOI ... E. M. Genden, A. Iskander, J. S. Bromberg, L. Mayer, The kinetics and pattern of tracheal allograft re-epithelialization, Am J ... M. Strome, S. Strome, J. Darrell, et al., The effects of cyclosporin A on transplanted rat allografts, Laryngoscope 103, 394- ... M. Haug, O. Dan, S. Wimberley, M. Fritz, R. R. Lorenz, M. Strome, Cyclosporine dose, serum trough levels, and allograft ...
Tissue-engineered collateral ligament composite allografts for scapholunate ligament reconstruction: an experimental study. ... Human flexor tendon tissue engineering: revitalization of biostatic allograft scaffolds. Tissue engineering. Part A Woon, C. Y ... Human Flexor Tendon Tissue Engineering: Revitalization of Biostatic Allograft Scaffolds TISSUE ENGINEERING PART A Woon, C. Y., ... Tissue-engineered Collateral Ligament Composite Allografts for Scapholunate Ligament Reconstruction: An Experimental Study ...
Tissue Surgery details the most current and multidisciplinary approaches to new technologies used in general plastic, hand, ... Clinical Application of Composite Tissue Allografts Maria Z. Siemionow, Sakir Unal, Galip Agaoglu ... Tissue Surgery details the most current and multidisciplinary approaches to new technologies used in general plastic, hand, ... Subcutaneous Tissue Function: The Multimicrovacuolar Absorbing Sliding System in Hand and Plastic Surgery ...
... substrates are modified to have an osteoinductive surface modification that the recipients body will accept as its own tissue ... GITELIS, S. AND PIASECKI, P. Allograft prosthetic composite arthroplasty for osteosarcoma and other aggressive bone tumors. ... However, bone allografts present with a number of tissue related characteristics which make the identification of a rejection ... MUSCOLO, D. L.; CALETTI, E.; SCHAJOWICZ, F.; ARAUJO, E. S.; AND MAKINO, A. Tissue-typing in human massive allografts of frozen ...
... resorbable natural soft tissue membrane; Group II - processed human allograft + resorbable natural soft tissue membrane . ... If insertion torque will be less, crown should be bond to neighboring teeth using composite material. ... resorbable natural soft tissue membrane; Group II - processed human allograft + resorbable natural soft tissue membrane . ... Soft and hard tissue assessment of immediate implant placement: a case series. Clin Oral Implants Res. 2007 Apr;18(2):237-43. ...
For additional information about Vascularized Composite Allograft organ transplants, see the Face and Hands Transplants page. ... are transplants involving several types of tissue. The best-known VCAs are hand, arm, and face transplants, but doctors have ... Vascularized composite allografts (VCAs) are transplants involving several types of tissue. The best-known VCAs are hand, arm, ... This video tells the story of Brendan Marrocco, a soldier who lost his limbs in Iraq, and the vascularized composite allografts ...
Publications] A.Ueda et al: Thy-1 antigen dendritic cell and rejection of composite tissue limb allografts in rats ... Publications] A.Ueda et al.: Thy-1 antigen dendritic cell and rejection of composite tissue limb allografts in rats ... Publications] Atsushi Ueda et al: Thy-1 antigen dendritic cells and rejection of composite tissue Limb allografts in rats ... 4 ; From morphometrical analysis, the content ratios of collagen fibrils in the reticular fibers in the lymphoid tissues were ...
Composite tissue allografts may need a higher percentage of donor chimerism compared with less immunogenic solid organ ... in the induction of stable and high level chimerism and subsequent donor-specific tolerance to composite tissue allograft ... of stable and high level mixed hematopoietic chimerism and subsequent donor specific tolerance in clinical composite tissue ... Subsequently, in the donor specific group, the survival time of hind-limb allografts without RAPA were remarkably prolonged ...
  • Allotransplant ( allo- meaning "other" in Greek ) is the transplantation of cells , tissues , or organs to a recipient from a genetically non-identical donor of the same species. (wikipedia.org)
  • Potential applications of tissue engineering in regenerative medicine range from structural tissues to organs with complex function. (springer.com)
  • Potential applications of tissue engineering in regenerative medicine range from structural tissues (e.g., skin, cartilage, bone) to complex organs (e.g., heart and other components of the cardiovascular system, liver, kidney, pancreas). (springer.com)
  • Your medical condition at the time of death will determine which organs and tissue can be donated. (thenorthwestern.com)
  • A national system matches available organs from the donor with people on the waiting list based on blood type, body size, how sick they are, donor distance, tissue type and time on the list. (thenorthwestern.com)
  • 2) Under existing law, it is a felony for a person to donate blood, body organs or other tissue, or semen to a medical center or semen bank who knows that he or she has acquired immunodeficiency syndrome (AIDS) except if the person is a sperm donor who has been screened and found nonreactive under the above provisions. (ca.gov)
  • Microencapsulation is a valuable technique for local, regional and oral delivery of therapeutic products as it can be implanted into numerous tissue types and organs. (wikipedia.org)
  • In this paper, a new-typed hydroxyapatite/collagen composite scaffold which was reinforced by chitosan fibers and cultured with osteoblasts and endothelial cells was fabricated. (hindawi.com)
  • Nanofiber-reinforced scaffold cultured with osteoblasts and endothelial cells can induce vascularized bone tissue formation. (hindawi.com)
  • In this paper, a new-typed hydroxyapatite/collagen composite scaffold reinforced by chitosan fibers and cultured with osteoblasts and endothelial cells which could support the vascularization of a complex tissue engineered construct for bone [ 8 ] has been discussed. (hindawi.com)
  • Preparation of a biphase composite scaffold and its application in tissue engineering for femoral. (deepdyve.com)
  • The tissue-engineered ligament (10) includes a scaffold of biocompatible material having at least one layer and forming a sheet (15). (google.com)
  • In a recent study published in Multifunctional Materials, IOP Science , Arun Kumar Teotia and co-workers at the Departments of bioengineering, orthopedics, chemical engineering and biomedical engineering, in India, Finland and Sweden developed a novel, multifunctional, bilayered composite scaffold (BCS). (phys.org)
  • The novel material contained ceramic nano-cement (NC) and the macroporous composite scaffold (CG) to mimic bone architecture during bone repair. (phys.org)
  • Followed by the macroporous composite scaffold (CG) functionalized with BMP and ZA (CG+BMP+ZA) at 9.2 mm 3 and BCS+ZA+BMP with 7.6 mm 3 of MT deposition. (phys.org)
  • To accomplish this, they generated a bilayered scaffold architecture that integrated a resorbable biphasic nano-hydroxyapatite-calcium sulphate ceramic nano-cement (NC) in the upper layer and silk-bioglass-hydroxyapatite composite porous cryogel (CG) as an underlying layer. (phys.org)
  • The present invention relates to a method of forming a tissue implant that includes applying force to the tissue to form the implant which has a predetermined shape. (google.co.uk)
  • The present invention relates to an implant for stabilizing body tissue. (google.com)
  • When used for bone/implant fixation, or as a filler or cement for bone repair, gradual biodegradation of the cement composite permits, under suitable circumstances, eventual replacement of the cement with developing bone tissue. (google.com)
  • Micro-CT scanning revealed both tools for stem cell implant in tissue-engineering. (deepdyve.com)
  • Increasingly, it is recognized that it is extremely important to facilitate the attachment of osteoblasts on the implant so that a proper foundation of extracellular matrix (ECM) can be laid down for the growth of new bone tissue. (medsci.org)
  • Massive bone loss around the knee has been managed historically with a massive tumour implant, an allograft or an allograft/prosthetic composite. (scielo.org.za)
  • A spinal implant includes a wall having a first surface and a second surface configured to engage tissue. (google.ca)
  • 12 . A spinal implant as recited in claim 1 , wherein the wall includes a plate such that the second surface engages anterior tissue. (google.ca)
  • 13 . A spinal implant as recited in claim 1 , wherein the second surface includes a planar face having at least one transverse extension configured to penetrate tissue. (google.ca)
  • Historically these massive bone defects have been reconstructed by either an endoprosthesis or a bulk allograft and considerable debate around this topic still persists. (scielo.org.za)
  • Tissue Surgery details the most current and multidisciplinary approaches to new technologies used in general plastic, hand, peripheral nerve, microsurgery, breast, esthetic, and trauma surgery and provides an overview of the most important and clinically relevant plastic surgery research. (springer.com)
  • In each case, there are limitations to conventional surgical approaches and existing prosthetic devices, serious complications associated with transplantation, and critical shortages of available donor tissues. (springer.com)
  • Biomaterials can be derived either from nature or synthesized in the laboratory using a variety of chemical approaches utilizing metallic components, polymers, ceramics or composite materials. (wikipedia.org)
  • High failure rates in prior studies of patients treated with allograft-prosthetic composites and an increased. (ebscohost.com)
  • Prosthetic: Lost tissue is replaced with synthetic materials such as metal, plastic, or ceramic (prosthetic implants). (wikipedia.org)
  • Major focus has been on the role of PPAR (peroxisome proliferators-activate receptor) transcription factors in adipose tissue formation, cell growth and cardiovascular disease (vascular and cardiac dysfunction in diabetes). (google.com)
  • A suspension of homogenized tissue (testis, kidney & spleen) from strain A mice was injected into fetuses of CBA strain mice. (omicsonline.org)
  • Conversely by transplanting between strains with similar haplotypes a chronic process can be elicited were the allograft kidney develops interstitial fibrosis and tubular atrophy. (jove.com)
  • We routinely isolate adult stem cells from adipose tissue and we study both the biology of the adipose-derived stem cells and the potential of the cells in tissue engineering applications. (upmc.com)
  • MSCs were isolated and expanded from human adipose tissue. (springer.com)
  • To address the broader role of adipose tissue inflammation in vascular disease, we have recently developed a model of visceral fat inflammation and demonstrated that visceral, but not subcutaneous fat inflammation, is sufficient to accelerate atherosclerosis - in the absence of diabetes. (google.com)
  • Tissue flap operations are extensive, often including microvascular surgery, and do not precisely correct the deformities. (pitt.edu)
  • Because he had concomitant extremity injuries (flap donor sites) and his defect was so large and included the lower abdominal wall, penis and scrotum, and some medial thigh tissue, conventional reconstructive options were very limited. (calgarysun.com)
  • The use of a free fibula flap inside a massive bone allograft provides a reliable reconstructive option. (elsevier.com)
  • 3. The method of claim 1 , wherein the core material has a first volume prior to and during implantation, the first volume providing for a reduced sized stabilizing device for implantation, and wherein the core material has a second volume after implantation, the second volume providing for a greater sized stabilizing device for stabilization of the tissue in the human body. (google.com)
  • In some embodiments, delivery methods are minimally invasive and include linear, lateral, and off-angle implantation or driving of anchors along, against or within tissue surfaces. (google.es)
  • The present project was performed for clarifying the structural characteristics of the reticular framework in lymphoid and hematopoietic tissues. (nii.ac.jp)
  • Each reticular frameworks in the lymphoid and hematopoietic tissues had specific antigens to react with the corresponded monoclonal antibodies which were recently produced in our laboratory. (nii.ac.jp)
  • Ultrastructurally, the reticular fibers in the lymphoid and hematopoietic tissues were a mixture of collagen fibrils and amorphous materials and almost completely ensheathed by the cytoplasma of fibrobrastic reticular cells. (nii.ac.jp)
  • From morphometrical analysis, the content ratios of collagen fibrils in the reticular fibers in the lymphoid tissues were significantly higher than those in the hematopoietic tissues involved the splenic red pulp. (nii.ac.jp)
  • During the reconstitution of splenic white pulp, the transferred lymphocytes and S-100beta positive dendritic cells homed respectivly in the collapsed reticular framework of splenic white pulp after bone marrow transplantation.13EA08 : These evidences suggest strongly that the each reticular frameworks in different components of the lymphoid and hematopoietic tissues set up optimal microenviroments for homing of certain free cells including blood cells, lymphocytes, macrophages and dendritic cells. (nii.ac.jp)