Complex Mixtures: Mixtures of many components in inexact proportions, usually natural, such as PLANT EXTRACTS; VENOMS; and MANURE. These are distinguished from DRUG COMBINATIONS which have only a few components in definite proportions.Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Spectrometry, Mass, Electrospray Ionization: A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.Polycyclic Compounds: Compounds consisting of two or more fused ring structures.Air Pollutants: Any substance in the air which could, if present in high enough concentration, harm humans, animals, vegetation or material. Substances include GASES; PARTICULATE MATTER; and volatile ORGANIC CHEMICALS.HydrocarbonsProteomics: The systematic study of the complete complement of proteins (PROTEOME) of organisms.Fuel Oils: Complex petroleum hydrocarbons consisting mainly of residues from crude oil distillation. These liquid products include heating oils, stove oils, and furnace oils and are burned to generate energy.Smog: A mixture of smoke and fog polluting the atmosphere. (Dorland, 27th ed)Environmental Monitoring: The monitoring of the level of toxins, chemical pollutants, microbial contaminants, or other harmful substances in the environment (soil, air, and water), workplace, or in the bodies of people and animals present in that environment.Chromatography, Liquid: Chromatographic techniques in which the mobile phase is a liquid.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Petroleum: Naturally occurring complex liquid hydrocarbons which, after distillation, yield combustible fuels, petrochemicals, and lubricants.Polycyclic Hydrocarbons, Aromatic: A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)Polychlorinated Biphenyls: Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.Environmental Pollutants: Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.Water Pollutants, Chemical: Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.Coal Tar: A by-product of the destructive distillation of coal used as a topical antieczematic. It is an antipruritic and keratoplastic agent used also in the treatment of psoriasis and other skin conditions. Occupational exposure to soots, tars, and certain mineral oils is known to be carcinogenic according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985) (Merck Index, 11th ed).Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Tandem Mass Spectrometry: A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.Odors: The volatile portions of substances perceptible by the sense of smell. (Grant & Hackh's Chemical Dictionary, 5th ed)Benzo(a)pyrene: A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Organic Chemicals: A broad class of substances containing carbon and its derivatives. Many of these chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form.Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.United States Environmental Protection Agency: An agency in the Executive Branch of the Federal Government. It was created as an independent regulatory agency responsible for the implementation of federal laws designed to protect the environment. Its mission is to protect human health and the ENVIRONMENT.Proteome: The protein complement of an organism coded for by its genome.Volatilization: A phase transition from liquid state to gas state, which is affected by Raoult's law. It can be accomplished by fractional distillation.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization: A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample-matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced, and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis.Mutagenicity Tests: Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.Air Pollution, Indoor: The contamination of indoor air.Dioxins: Chlorinated hydrocarbons containing heteroatoms that are present as contaminants of herbicides. Dioxins are carcinogenic, teratogenic, and mutagenic. They have been banned from use by the FDA.Toxicity Tests: An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Hazardous Waste: Waste products which threaten life, health, or the environment when improperly treated, stored, transported, disposed of, or otherwise managed.DNA Adducts: The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.Chromatography, Gas: Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Chemical Fractionation: Separation of a mixture in successive stages, each stage removing from the mixture some proportion of one of the substances, for example by differential solubility in water-solvent mixtures. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Particulate Matter: Particles of any solid substance, generally under 30 microns in size, often noted as PM30. There is special concern with PM1 which can get down to PULMONARY ALVEOLI and induce MACROPHAGE ACTIVATION and PHAGOCYTOSIS leading to FOREIGN BODY REACTION and LUNG DISEASES.Electrophoresis, Microchip: A highly miniaturized version of ELECTROPHORESIS performed in a microfluidic device.Chemistry Techniques, Analytical: Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.Coal: A natural fuel formed by partial decomposition of vegetable matter under certain environmental conditions.Benzene DerivativesCarcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Ions: An atom or group of atoms that have a positive or negative electric charge due to a gain (negative charge) or loss (positive charge) of one or more electrons. Atoms with a positive charge are known as CATIONS; those with a negative charge are ANIONS.SmokeBiological Assay: A method of measuring the effects of a biologically active substance using an intermediate in vivo or in vitro tissue or cell model under controlled conditions. It includes virulence studies in animal fetuses in utero, mouse convulsion bioassay of insulin, quantitation of tumor-initiator systems in mouse skin, calculation of potentiating effects of a hormonal factor in an isolated strip of contracting stomach muscle, etc.Benzopyrenes: A class of chemicals that contain an anthracene ring with a naphthalene ring attached to it.Xenobiotics: Chemical substances that are foreign to the biological system. They include naturally occurring compounds, drugs, environmental agents, carcinogens, insecticides, etc.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Chromatography, Ion Exchange: Separation technique in which the stationary phase consists of ion exchange resins. The resins contain loosely held small ions that easily exchange places with other small ions of like charge present in solutions washed over the resins.Benzofurans: Compounds that contain a BENZENE ring fused to a furan ring.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Gases: The vapor state of matter; nonelastic fluids in which the molecules are in free movement and their mean positions far apart. Gases tend to expand indefinitely, to diffuse and mix readily with other gases, to have definite relations of volume, temperature, and pressure, and to condense or liquefy at low temperatures or under sufficient pressure. (Grant & Hackh's Chemical Dictionary, 5th ed)Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.Chromatography, Thin Layer: Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Environmental Exposure: The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Aerosols: Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.Cytochrome P-450 CYP1A1: A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.Smell: The ability to detect scents or odors, such as the function of OLFACTORY RECEPTOR NEURONS.Solvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Vehicle Emissions: Gases, fumes, vapors, and odors escaping from the cylinders of a gasoline or diesel internal-combustion engine. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed & Random House Unabridged Dictionary, 2d ed)Particle Size: Relating to the size of solids.Occupational Exposure: The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.Epidemiological Monitoring: Collection, analysis, and interpretation of data about the frequency, distribution, and consequences of disease or health conditions, for use in the planning, implementing, and evaluating public health programs.Metabolomics: The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.Peptide Mapping: Analysis of PEPTIDES that are generated from the digestion or fragmentation of a protein or mixture of PROTEINS, by ELECTROPHORESIS; CHROMATOGRAPHY; or MASS SPECTROMETRY. The resulting peptide fingerprints are analyzed for a variety of purposes including the identification of the proteins in a sample, GENETIC POLYMORPHISMS, patterns of gene expression, and patterns diagnostic for diseases.Glycopeptides: Proteins which contain carbohydrate groups attached covalently to the polypeptide chain. The protein moiety is the predominant group with the carbohydrate making up only a small percentage of the total weight.Cell Extracts: Preparations of cell constituents or subcellular materials, isolates, or substances.Dust: Earth or other matter in fine, dry particles. (Random House Unabridged Dictionary, 2d ed)Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Trypsin: A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 22.214.171.124.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Tobacco Smoke Pollution: Contamination of the air by tobacco smoke.Isotope Labeling: Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.Tetrachlorodibenzodioxin: A chemical by-product that results from burning or incinerating chlorinated industrial chemicals and other hydrocarbons. This compound is considered an environmental toxin, and may pose reproductive, as well as, other health risks for animals and humans.EstersDrug Interactions: The action of a drug that may affect the activity, metabolism, or toxicity of another drug.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Isomerism: The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Receptors, Aryl Hydrocarbon: Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Nanotechnology: The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.PolysaccharidesMolecular Weight: The sum of the weight of all the atoms in a molecule.Kinetics: The rate dynamics in chemical or physical systems.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Air Pollutants, Occupational: Air pollutants found in the work area. They are usually produced by the specific nature of the occupation.Spectroscopy, Fourier Transform Infrared: A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.Time Factors: Elements of limited time intervals, contributing to particular results or situations.PhosphopeptidesBlood Proteins: Proteins that are present in blood serum, including SERUM ALBUMIN; BLOOD COAGULATION FACTORS; and many other types of proteins.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Electrophoresis, Gel, Two-Dimensional: Electrophoresis in which a second perpendicular electrophoretic transport is performed on the separate components resulting from the first electrophoresis. This technique is usually performed on polyacrylamide gels.Reference Standards: A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.Chromatography: Techniques used to separate mixtures of substances based on differences in the relative affinities of the substances for mobile and stationary phases. A mobile phase (fluid or gas) passes through a column containing a stationary phase of porous solid or liquid coated on a solid support. Usage is both analytical for small amounts and preparative for bulk amounts.Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.DNA Damage: Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Air Pollution: The presence of contaminants or pollutant substances in the air (AIR POLLUTANTS) that interfere with human health or welfare, or produce other harmful environmental effects. The substances may include GASES; PARTICULATE MATTER; or volatile ORGANIC CHEMICALS.Nuclear Magnetic Resonance, Biomolecular: NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Sequence Analysis: A multistage process that includes the determination of a sequence (protein, carbohydrate, etc.), its fragmentation and analysis, and the interpretation of the resulting sequence information.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Chromatography, Affinity: A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. It is used in protein biochemistry. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Lipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Glycosylation: The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Protein Processing, Post-Translational: Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Plant Proteins: Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.Equipment Design: Methods of creating machines and devices.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Models, Molecular: Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)RNA: A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Lymphocytes: White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.Cell Line, Tumor: A cell line derived from cultured tumor cells.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Bacterial Proteins: Proteins found in any species of bacterium.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Saccharomyces cerevisiae: A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.DNA, Complementary: Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Genetic Variation: Genotypic differences observed among individuals in a population.
Cell death during corneal storage at 4 degrees C. (1/369)PURPOSE: To evaluate cell death in human donor corneas stored at 4 degrees C, to determine whether terminal deoxynucleotidyl transferase-mediated dUTP-fluorescein nick-end labeling (TUNEL) discriminates between apoptosis and necrosis in corneas stored at 4 degrees C. METHODS: Ten human corneas were stored in Optisol (Chiron Ophthalmics, Irvine, CA) at 4 degrees C for periods ranging from 0 to 21 days and then fixed for histologic examination. Central corneal sections from each cornea were examined by transmission electron microscopy (TEM) and by the TUNEL assay. Electron micrographs of at least 15 keratocytes each from the anterior, middle, and posterior stroma were examined by three masked observers who graded each cell as normal, apoptotic, or necrotic. Central sections from the same corneas were processed by the TUNEL assay and evaluated with a laser scanning confocal microscope to determine the percentage of apoptotic cells. RESULTS: By TEM, apoptosis occurred in 23% of the keratocytes and necrosis in 12%. By TUNEL assay, apoptosis occurred in 11% of the keratocytes, with the results in individual corneas being similar to the findings by TEM for apoptosis, rather than for necrosis. By TUNEL assay, apoptosis occurred in 13% of the epithelial cells and in 8% of the endothelial cells. The percentage of apoptotic cells and storage time correlated significantly for the epithelium, but not for the keratocytes or endothelium in this small sample. CONCLUSIONS: Both apoptosis and necrosis occur in cells during corneal storage at 4 degrees C, with apoptosis appearing to predominate. The TUNEL assay identifies cells undergoing apoptosis, but not necrosis, in corneal tissue. Inhibition of apoptosis in corneas stored at 4 degrees C may prolong acceptable storage times. (+info)
Effectiveness of microabrasion technique for improvement of dental aesthetics. (2/369)OBJECTIVES: To investigate which types of enamel opacity are effectively treated by the microabrasion technique and whether this technique could be used as a diagnostic aid to determine the aetiology of these defects. MATERIALS AND METHOD: Thirty two patients who had enamel opacities affecting both upper central incisors were selected and the disfigurements were classified into four types: single line, multi-line, patched and diffused. The patient's previous medical history, possible history of fluoride ingestion, presence of taurodontism and family history of similar enamel defects were recorded. Both incisors were treated with Prema abrasive paste mixed with 18% hydrochloric acid. The aesthetic improvements were assessed by the patients and their parents and their satisfaction level after the treatment was recorded. RESULTS: Approximately two-thirds (65.6%) of the patients were satisfied with their appearance after microabrasion. Apart from four patients, the improved appearance was stable and acceptable to the remaining patients at the six month recall. Statistical analysis showed that acceptable improvement was found in patients with single line/patched types of defects but not in multi-line/diffused types (P = 0.03). However, the aesthetic improvement was not related to the patient's fluoride history, presence of taurodontism or the family history of enamel defects. CONCLUSION: Microabrasion using Prema abrasives with 1 8% HCI is effective in improving the appearance of enamel with single-line or patched opacities, indicating that these defects are a surface phenomenon. For the multi-line and diffused types, the defects appear to extend deeper into the enamel. The technique failed to assist in determining the aetiology of these defects. (+info)
GFS, a preparation of Tasmanian Undaria pinnatifida is associated with healing and inhibition of reactivation of Herpes. (3/369)BACKGROUND: We sought to assess whether GFS, a proprietary preparation of Tasmanian Undaria pinnatifida, has effects on healing or re-emergence of Herpetic infections, and additionally, to assess effects of GFS in vitro. Undaria is the most commonly eaten seaweed in Japan, and contains sulphated polyanions and other components with potential anti-viral activity. Herpes simplex virus type 1 (HSV-1) infections have lower reactivation rates and Herpes type 2 (HSV-2) infections have lower incidence in Japan than in the west. METHODS: Patients with active (15 subjects) or latent (6 subjects) Herpetic infections (HSV-1, 2, EBV, Zoster) were monitored for response to ingestion of GFS. GFS extract was tested in vitro for human T cell mitogenicity and anti-Herpes activity. RESULTS: Ingestion of GFS was associated with increased healing rates in patients with active infections. In addition, patients with latent infection remained asymptomatic whilst ingesting GFS. GFS extract inhibited Herpes viruses in vitro and was mitogenic to human T cells in vitro. CONCLUSIONS: Ingestion of GFS has inhibitory effects on reactivation and is associated with increased rate of healing after Herpetic outbreaks. GFS extract potently inhibited Herpes virus in vitro, and had mitogenic effects on human T cells. (+info)
The use of antimicrobial peptides in ophthalmology: an experimental study in corneal preservation and the management of bacterial keratitis. (4/369)PURPOSE: Bacterial keratitis is an ocular infection with the potential to cause significant visual impairment. Increasing patterns of antibiotic resistance have necessitated the development of new antimicrobial agents for use in bacterial keratitis and other serious ocular infections. With a view to exploring the use of novel antimicrobial peptides in the management of ocular infection, we performed a series of experiments using synthetic antimicrobial peptides designed for the eradication of common and serious ophthalmic pathogens. METHODS: Experiments were performed with three clinical ocular isolates--Pseudomonas aeruginosa, Staphylococcus aureus, and Staphylococcus epidermidis--in three experimental settings: (1) in vitro in a controlled system of 10 mM sodium phosphate buffer, (2) in vitro in modified chondroitin sulfate-based corneal preservation media (Optisol), and (3) in an in vivo animal model (rabbit) simulating bacterial keratitis. In all cases, outcomes were measured by quantitative microbiological techniques. RESULTS: The candidate peptides (CCI A, B, and C and COL-1) produced a total reduction of the test pathogens in phosphate buffered saline. In modified Optisol, the peptides were effective against S epidermidis at all temperatures, demonstrated augmented activity at 23 degrees C against the gram-positive organisms, but were ineffective against P aeruginosa. The addition of EDTA to the medium augmented the killing of P aeruginosa but made no difference in the reduction of gram-positive organisms. In an in vivo rabbit model of Pseudomonas keratitis, COL-1 demonstrated neither clinical nor microbicidal efficacy and appeared to have a very narrow dosage range, outside of which it appeared to be toxic to the ocular surface. CONCLUSION: Our data indicate that the antimicrobial peptides we tested were effective in vitro but not in vivo. In an age of increasing antibiotic resistance, antimicrobial peptides, developed over millions of years as innate defense mechanisms by plants and animals, may have significant potential for development as topical agents for the management of severe bacterial keratitis. However, modifications of the peptides, the drug delivery systems, or both, will be necessary for effective clinical application. (+info)
Crude extracts of bacterially expressed dsRNA can be used to protect plants against virus infections. (5/369)BACKGROUND: Double-stranded RNA (dsRNA) is a potent initiator of gene silencing in a diverse group of organisms that includes plants, Caenorhabditis elegans, Drosophila and mammals. We have previously shown and patented that mechanical inoculation of in vitro-transcribed dsRNA derived from viral sequences specifically prevents virus infection in plants. The approach required the in vitro synthesis of large amounts of RNA involving high cost and considerable labour. RESULTS: We have developed an in vivo expression system to produce large amounts of virus-derived dsRNAs in bacteria, with a view to providing a practical control of virus diseases in plants. Partially purified bacterial dsRNAs promoted specific interference with the infection in plants by two viruses belonging to the tobamovirus and potyvirus groups. Furthermore, we have demonstrated that easy to obtain, crude extracts of bacterially expressed dsRNAs are equally effective protecting plants against virus infections when sprayed onto plant surfaces by a simple procedure. Virus infectivity was significantly abolished when plants were sprayed with French Press lysates several days before virus inoculation. CONCLUSION: Our approach provides an alternative to genetic transformation of plant species with dsRNA-expressing constructs capable to interfere with plant viruses. The main advantage of this mode of dsRNA production is its simplicity and its extremely low cost compared with the requirements for regenerating transgenic plants. This approach provides a reliable and potential tool, not only for plant protection against virus diseases, but also for the study of gene silencing mechanisms in plant virus infections. (+info)
Protein stability in mixed solvents: a balance of contact interaction and excluded volume. (6/369)Changes in excluded volume and contact interaction with the surface of a protein have been suggested as mechanisms for the changes in stability induced by cosolvents. The aim of the present paper is to present an analysis that combines both effects in a quantitative manner. The result is that both processes are present in both stabilizing and destabilizing interactions and neither can be ignored. Excluded volume was estimated using accessible surface area calculations of the kind introduced by Lee and Richards. The change in excluded volume on unfolding, deltaX, is quite large. For example, deltaX for ribonuclease is 6.7 L in urea and approximately 16 L in sucrose. The latter number is greater than the molar volume of the protein. Direct interaction with the protein is represented as the solvent exchange mechanism, which differs from ordinary association theory because of the weakness of the interaction and the high concentrations of cosolvents. The balance between the two effects and their contribution to overall stability are most simply presented as bar diagrams as in Fig. 3. Our finding for five proteins is that excluded volume contributes to the stabilization of the native structure and that contact interaction contributes to destabilization. This is true for five proteins and four cosolvents including both denaturants and osmolytes. Whether a substance stabilizes a protein or destabilizes it depends on the relative size of these two contributions. The constant for the cosolvent contact with the protein is remarkably uniform for four of the proteins, indicating a similarity of groups exposed during unfolding. One protein, staphylococcus nuclease, is anomalous in almost all respects. In general, the strength of the interaction with guanidinium is about twice that of urea, which is about twice that of trimethylamine-N-oxide and sucrose. Arguments are presented for the use of volume fractions in equilibrium equations and the ignoring of activity coefficients of the cosolvent. It is shown in the Appendix that both the excluded volume and the direct interaction can be extracted in a unified way from the McMillan-Mayer formula for the second virial coefficient. (+info)
Solvation of nucleosides in aqueous mixtures of organic solvents: relevance to DNA open basepairs. (7/369)Toward the goal of understanding how open basepairs in DNA interact with their heterogeneous environment, we have studied the steady-state intrinsic fluorescence properties of the purine and pyrimidine deoxynucleosides in organic solvents in the presence of small amounts of water. The organic solvents used in the present study were: n-butanol, acetonitrile, methanol, n-propanol, isopropanol, and isobutanol. For n-butanol and acetonitrile, which have a high degree of amphiphilicity and weak hydrogen bonding ability, respectively, the fluorescence spectral properties of the purines are found to depend on the sequence of steps in which the aqueous mixtures were formed. By contrast, no such dependence was observed in the mixtures with any of the other solvents used in the present study. Moreover, no such dependence was observed for the pyrimidines. These findings suggest that the final solvation network around the purines is dependent on the nature of the environment to which they were initially exposed. This would tend to present an impediment to the closing of AT or GC basepairs in DNA that become open as a result of structural fluctuations, DNA bending, or protein-DNA interactions. (+info)
Egg hatching, larval movement and larval survival of the malaria vector Anopheles gambiae in desiccating habitats. (8/369)BACKGROUND: Although the effects of rainfall on the population dynamics of the malaria vector Anopheles gambiae have been studied in great detail, the effects of dry periods on its survival remain less clear. METHODS: The effects of drying conditions were simulated by creating desiccated habitats, which consisted of trays filled with damp soil. Experiments were performed in these trays to (i) test the ability of An. gambiae sensu stricto eggs to hatch on damp soil and for larvae to reach an artificial breeding site at different distances of the site of hatching and (ii) to record survival of the four larval stages of An. gambiae s.s. when placed on damp soil. RESULTS: Eggs of An. gambiae s.s. hatched on damp soil and emerging larvae were capable of covering a distance of up to 10 cm to reach surface water enabling further development. However, proportions of larvae reaching the site decreased rapidly with increasing distance. First, second and third-instar larvae survived on damp soil for an estimated period of 64, 65 and 69 hrs, respectively. Fourth-instar larvae survived significantly longer and we estimated that the maximum survival time was 113 hrs. CONCLUSION: Short-term survival of aquatic stages of An. gambiae on wet soil may be important and adaptive when considering the transient nature of breeding sites of this species in sub-Saharan Africa. In addition, the results suggest that, for larval vector control methods to be effective, habitats should remain drained for at least 5 days to kill all larvae (e.g. in rice fields) and habitats that recently dried up should be treated as well, if larvicidal agents are applied. (+info)
Unresolved complex mixture
... (also UCM or hump) is a feature frequently observed in gas chromatographic (GC) data of crude oils ... The use of GC×GC for the characterization of complex petrochemical mixtures has been extensively reviewed. Most research into ... Analysis of the hydrocarbon fraction of crude oils by gas chromatography (GC) reveals a complex mixture containing many ... Unresolved Complex Mixtures of Aromatic Hydrocarbons: Thousands of Overlooked Persistent, Bioaccumulative, and Toxic ...
Rutherford Aris bibliography
Chemical Reactions in Complex Mixtures, (pp. 25-41). New York: Van Nostrand Reinhold, 1991. "The mathematics of continuous ... A286, 129-139 (1965). "On the theory of reactions in continuous mixtures" (with G.R. Gavalas). Phil. Trans. Roy. Soc. A 260, ... 49, 5307-5313 (1994). "Pt-catalyzed combustion of CH4-C3-C8 mixtures" (with A. Balakrishna and L.D. Schmidt). Chem. Eng. Sci. ... Tech., 99 (1995). "On reactions in continuous mixtures." A.I.Ch.E.J. 35, 539-548 (1989). "On the limits of facilitated ...
Polycyclic aromatic hydrocarbon
PAHs are typically found as complex mixtures. Lower-temperature combustion, such as tobacco smoking or wood-burning, tends to ... These metabolites can bind to DNA at specific sites, forming bulky complexes called DNA adducts that can be stable or unstable ... PAHs are among the complex suite of contaminants in cigarette smoke and particulate air pollution and may contribute to ... In 1922, Ernest Kennaway determined that the carcinogenic component of coal tar mixtures was an organic compound consisting of ...
"CHARACTERISATION OF UNRESOLVED COMPLEX MIXTURES OF HYDROCARBONS" (PDF). University of Plymouth, PhD theses. "Honorary Members, ...
Allotropes of sulfur
It contains a complex mixture of catena-sulfur forms mixed with cyclo-forms. This is obtained by washing quenched liquid sulfur ... It is a mixture of ψ-sulfur and lamina sulfur. The composition depends on the exact method of production and the samples ... Contains mixture of Sn rings. This term is applied to biradical catena- chains in sulfur melts or the chains in the solid. ... It is sometimes called polymeric sulfur, μ-S or ω-S. This is a mixture of the allotropic ψ- form and γ-cycloS8. This is a ...
Multiple displacement amplification
Chromatin Immunoprecipitation results in production of complex mixtures of relatively short DNA fragments, which is challenging ... "Multiple displacement amplification for complex mixtures of DNA fragments". BMC Genomics. 9: 415. doi:10.1186/1471-2164-9-415. ... A method to circumvent this problem was proposed, which is based on conversion of these mixtures to circular concatemers using ...
... (CPs) are complex mixtures of polychlorinated n-alkanes. The chlorination degree of CPs can vary between ...
Simple fluorinations of alkenes often produce complex mixtures of products. However, cofluorination in the presence of a ...
... is a complex mixture of stereoisomers. The molecule contains three asymmetric carbon atoms, there is cis-trans ...
A number of different tags have been developed to help researchers purify specific proteins from complex mixtures. The study of ... Hey J, Posch A, Cohen A, Liu N, Harbers A (2008). "Fractionation of complex protein mixtures by liquid-phase isoelectric ... A more complex computational problem is the prediction of intermolecular interactions, such as in molecular docking and protein ... The resulting mixture can be purified using ultracentrifugation, which fractionates the various cellular components into ...
Rosin consists of a complex mixture of different substances including organic acids named the resin acids. These are closely ... They are often mixtures of organic compounds, principally terpenes. Many plants, particularly woody plants, produce resin in ... Oleoresins are naturally occurring mixtures of an oil and a resin; they can be extracted from various plants. Other resinous ...
Tunable resistive pulse sensing
Nanopore-based detection allows particle-by-particle assessment of complex mixtures. Optimization of pore size to particle size ...
Toxic equivalency factor
The complex nature of chemicals mixtures in the environment presents a challenge to risk assessment. The TEF approach was ... An effect-additive mixture response occurs when the combined effect of exposure a chemical mixture is equal to the sums of the ... Nevertheless, In vivo mixture studies have shown that WHO 1998 TEF values predicted mixture toxicity within a factor of two or ... Humans and wildlife are rarely exposed to solitary contaminants, but rather to complex mixtures of potentially harmful ...
Isotope-coded affinity tag
Gygi SP, Rist B, Gerber SA, Turecek F, Gelb MH, Aebersold R (October 1999). "Quantitative analysis of complex protein mixtures ... US 6670194 "Rapid quantitative analysis of proteins or protein function in complex mixtures," Rudolf Hans Aebersold et al. Yi, ...
The Great Reset
The suburb versus city debate will not produce a winner; the solution is a complex mixture of the two. They will both become ...
... or a complex mixture of these and other factors. The most common sources of the variations in rivers and streams that create ...
... is used in many different fields and is applied to pure samples as well as complex mixtures. A mass spectrum ... It differs from GC/MS in that the mobile phase is liquid, usually a mixture of water and organic solvents, instead of gas. Most ... Found mostly in the operating room, they were a part of a complex system, in which respired gas samples from patients ... Pharmacokinetics is often studied using mass spectrometry because of the complex nature of the matrix (often blood or urine) ...
Flame ionization detector
This allows for the rapid analysis of complex mixtures that contain molecules where standards are not available. To detect ... high-resolution characterization of complex mixtures". Lab Chip. 15 (2): 440-7. doi:10.1039/c4lc01180e. PMID 25387003. "Slide ... The eluent/fuel/oxidant mixture continues to travel up to the nozzle head where a positive bias voltage exists (E). This ...
The chromatographic purification of proteins from complex mixtures can be quite challenging, particularly when the mixtures ... 2D-LC/MS techniques for the identification of proteins in highly complex mixtures. Expert Reviews in Proteomics. Vol. 1, No. 1 ... Displacement chromatography is well suited for obtaining mg quantities of purified proteins from complex mixtures using ... displacement chromatography is an efficient technique for the purification of proteins from complex mixtures at high column ...
This synthesis leads to a very complex mixture with diverse nonylphenols. Theoretically there are 211 constitutional isomers ... The mixture of nonylphenol isomers is a pale yellow liquid, although the pure compounds are colorless. The nonylphenols are ... Industrially, nonylphenols are produced by the acid-catalyzed alkylation of phenol with a mixture of nonenes. ... Occurrence and quantification in two commercial mixtures". Chemosphere. 60 (11): 1624-1635. doi:10.1016/j.chemosphere.2005.02. ...
Laboratory B in Sungul'
Development of spectroscopic methods for the analysis of complex mixtures of radioactive components. Study of the precipitation ...
... high-resolution characterization of complex mixtures". Lab Chip. 15 (2): 440-7. doi:10.1039/c4lc01180e. PMID 25387003. ... Thus, the use of methanizers typically require complex valve systems that may include backflush and heartcuts. These systems ...
Tobacco smoke is a complex mixture of more than 5,300 identified chemicals. The most important carcinogens in tobacco smoke ... Group 3: the agent (mixture or exposure circumstance) is not classifiable as to its carcinogenicity to humans. Group 4: the ... Group 2A: the agent (mixture) is probably carcinogenic to humans. The exposure circumstance entails exposures that are probably ... Group 2B: the agent (mixture) is possibly carcinogenic to humans. The exposure circumstance entails exposures that are possibly ...
It is composed of a complex mixture of petroleum hydrocarbons. Simms, Christian G. (March 2001). "JP-8+100LT: A low cost ...
The complex mixture of natural cannabinoids". Life Sciences. NATURECEUTICALS (NATURAL PRODUCTS), NUTRACEUTICALS, HERBAL ...
List of food additives
Thickeners Thickeners are substances which, when added to the mixture, increase its viscosity without substantially modifying ... Sage (Salvia officinalis) - Copper complexes of chlorophylls - color (green) Coriander - Coriander seed oil - used medicinally ...
Downloadable! In finite mixture model clustering, each component of the fitted mixture is usually associated with a cluster. In other words, each component of the mixture is interpreted as the probability distribution of the variables of interest conditionally on the membership to a given cluster. The Gaussian mixture model (GMM) is very popular in this context for its simplicity and flexibility. It may happen, however, that the components of the fitted model are not well separated. In such a circumstance, the number of clusters is often overestimated and a better clustering could be obtained by joining some subsets of the partition based on the fitted GMM. Some methods for the aggregation of mixture components have been recently proposed in the literature. In this work, we propose a hierarchical aggregation algorithm based on a generalisation of the definition of silhouette-width taking into account the Mahalanobis distances induced by the precison matrices of the components of the fitted GMM. The
Sham will present the paper "Competitive Algorithms for VWAP and Limit Order Trading, S. Kakade, M. Kearns, Y. Mansour and L. Ortiz. Wed Oct 6: Guest Speaker Yee Whye Teh, UC Berkeley Hierarchical Dirichlet processes: A Bayesian approach to sharing clusters among related groups Abstract: We consider problems involving groups of data, where each observation within a group is drawn from a mixture model, and where it is desirable to share mixture components both within and between groups. We assume that the number of mixture components is unknown a priori and is to be inferred from data. Such problems occur often in practice, e.g. in the problem of topic discovery in document corpora, each document is treated as a group of data items (bag of words), and each topic corresponds to a mixture component. In this setting, sharing components between groups simply means that topics can occur across a number of documents, allowing dependencies across documents (groups) to be modeled effectively as well as ...
Compounds satisfied Lipinskis Rule of Five in evaluating druglikeness. Query: (-5:5[LOGP]) AND (0:500[MOLWT]) AND (0:5[HBDC]) AND (0:10[HBAC ...
Compounds satisfied Lipinskis Rule of Five in evaluating druglikeness. Query: (-5:5[LOGP]) AND (0:500[MOLWT]) AND (0:5[HBDC]) AND (0:10[HBAC ...
salt lake potash manufacturers salt lake potash suppliers Directory - Browse salt lake potash products,Choose Quality salt lake potash manufacturers, suppliers, factory at B2BAGE
IC Potash Receives Jurisdictional Determination From U.S. Army Corps of Engineers for Ochoa Potash Project
TORONTO--(Marketwired - Jun 11, 2013) - IC Potash Corp. (ICP or the Company) (TSX: ICP) (OTCQX: ICPTF) today announced that the U.S. Army Corps of Engineers (Corps) has issued the Company a Jurisdictional Determination confirming that there are no Waters of the United States on the Ochoa Sulphate of Potash...
Continued good demand for potash and magnesium products, the further stabilisation of potash prices on a low level and a positive special item of about € 30 million characterised the business development of the K+S Group from April to June 2014. EBIT I for the quarter was only slightly below the figure of a year ago, but down significantly when adjusted for the extraordinary effect.. "Giving the starting position on global potash markets, we had a solid first half of the year", says Norbert Steiner, chairman of the Board of Executive Directors of K+S Aktiengesellschaft. "The good salt business in North America and the positive development of our fertilizer specialties were particularly pleasing. We are making good progress on "Fit for the Future" and our Legacy Project.". In the first half of the year, the K+S Group saw revenues fall by about 8% to € 1.97 billion. Higher sales volumes in the Salt business unit in the wake of the severe winter in North America could only partially offset ...
Grades 7 12. Students use planning skills, logic, and trial-and-error to construct a flowchart that details how to separate a mixture of sand, iron filings, sodium chloride, and stearic acid. They first perform a warm-up activity to determine the mixture components physical properties. Student...
Target analytes are nitroaromatic and nitramine explosives and their degradation products. Obtaining pure, neat compounds for Method 8330 reference standards can be very difficult. To ensure the highest quality standards, Resteks Quality Control (QC) lab confirms the identity and purity of mixture components and solvents using one or more of the following techniques: GC-FID, HPLC, GC-ECD, GC-MS, LC-MS, refractive index, and melting point ...
Downloadable! This paper exploits the fact that implied volatilities calculated from identical call and put options have often been empirically found to differ, although they should be equal in theory. We propose a new bivariate mixture multiplicative error model and show that it is a good fit to Nikkei 225 index call and put option implied volatility (IV). A good model fit requires two mixture components in the model, allowing for different mean equations and error distributions for calmer and more volatile days. Forecast evaluation indicates that in addition to jointly modeling the time series of call and put IV, cross effects should be added to the model: putside implied volatility helps forecast callside IV, and vice versa. Impulse response functions show that the IV derived from put options recovers faster from shocks, and the effect of shocks lasts for up to six weeks.
Abstract Polymer spots with entrapped glucose oxidase were fabricated on glass surfaces and the localized enzymatic response was subsequently visualized using scanning electrochemical microscopy (SECM) in the generator,collector mode. SECM images were obtained under simultaneous variation of the concentration of glucose (0,6,mM) and ascorbic acid (0,200,,M), or, in a second set of experiments, of glucose (0,2,mM) and 2-deoxy- D(+)-glucose (0,4,mM). Aiming at the quantification of the mixture components discretization of the response surfaces of the overall enzyme/polymer spot into numerous spatially defined microsensor substructures was performed. Sensitivity of sensor substructures to measured analytes was calculated and patterns of variability in the data were analyzed before and after elimination of interferences using principal component analysis. Using artificial neural networks which were fed with the data provided by the sensor substructures showing highest sensitivity for glucose, ...
Bioconductor version: Development (3.7) Merging of mixture components for model-based automated gating of flow cytometry data using the flowClust framework. Note: users should have a working copy of flowClust 2.0 installed.. Author: Greg Finak ,gfinak at fhcrc.org,, Raphael Gottardo ,rgottard at fhcrc.org, Maintainer: Greg Finak ,gfinak at fhcrc.org, ...
The plenary session was opened by the coordinator of ATHON - Dr. Helen Håkansson of the Karolinska Institutet in Sweden - who gave a brief introduction on the ATHON project and the relevance of mixture toxicity for NDL-PCB risk assessment. Next, Dr. Thomas Backhaus (University of Gothenburg, Sweden), gave an introduction to the general principles of "concentration addition" (CA) and "independent action" (IA) within mixture toxicity, which was illustrated with an abundance of practical examples. The general conclusion from his presentation was that for hazard and risk assessment, the selection between a CA or IA model seems to be of minor importance. Keeping in mind the adage "seek simplicity but distrust it", Dr. Backhaus advocated that CA might be a simple default assumption to start with and to work further from. The third plenary speaker was Dr. Niklas Johansson (Swedish EPA and Karolinska Institutet) who demonstrated the use of a Central Composite, Face centered (CCF) statistical test ...
Captive® Clay Blinder for Potash Beneficiating « « Products | The ingredients of opportunity - Arclin.
Using traditional beneficiating methods, even the "cleanest" potash can still contain unwanted clay particles. Imagine increasing the yield still further - up to 95%-while using considerably fewer resources.. Arclins high performing Captive® Clay Blinder for Potash has been engineered for specific ore bodies, attaching to even the finest particles of clay and sand and removing them quickly and efficiently from valuable mined materials. This innovative blinder compensates for the limitations of standard technology and equipment, providing better outcomes for your business and the environment.. ...
Biofertilizers Market (Nitrogen Fixing, Phosphate Solubilizing, Potash Mobilizing) Worth $10.2 Billion by 2017 - New Report by...
Health,(PRWEB) October 26 2013 The report Global Biofertilizers Market by Types (Nitrogen Fixing Phosphate Solubilizing And Potash Mobilizing) Applications & Geography - Trends and Forecasts to 2017 defines and segments the global biofertilizers market with analysis and forecasting of the global revenue for biofertilizers. It also identifies the d,Biofertilizers,Market,(Nitrogen,Fixing,,Phosphate,Solubilizing,,Potash,Mobilizing),Worth,$10.2,Billion,by,2017,-,New,Report,by,MarketsandMarkets,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Potash Mobilizing Bacteria - Potash Mobilizing Bacteria Exporter, Importer, Manufacturer, Service Provider, Distributor,...
NATURE AGROCARE & RESEARCH PVT. LTD. - Exporter, Importer, Manufacturer, Service Provider, Distributor, Supplier, Trading Company, Wholesaler, Retailer & Dealer of Potash Mobilizing Bacteria based in Indore, India
Sufiy.: Extensive High-Grade Potash Discovery at International Lithium's Mariana Brine Project ILC.v, TNR.v
We are very encouraged with the results from the Phase 1 resource delineation drilling at Mariana that confirmed our belief in the potential of this multi-commodity potash-lithium-boron brine project. The observed extent of high grade potash brine encountered provides ILC the support and confidence to continue to advance our plans towards development. The objective for the next stage of exploration is to complete the remaining 10 to 12 holes needed for delineation drilling in conjunction with hydrogeological testing required to produce a reportable resource. Drilling will be designed to test structures that may control higher grade potash, lithium or boron zones" states Kirill Klip, President of the Company.The Company has received analytical results for Phase 1 of the Resource Delineation drilling program at the Companys 100% owned Mariana potash-lithium-boron brine project. Four (4) widely spaced drill holes (totalling 444 metres), were positioned approximately 5 km apart to characterize the ...
Interested in potash investing, but not sure where to start? Heres what you need to know about potash, from supply and demand to prices to stocks.
... Cheap High Potash, find High Potash deals on line at phosphate mining in south africa and its effect on aids Find the cheap High Potash, Find the best High Potash deals, Sourcing the right Gold potash+ is one of the most advanced root based phosphorus boosters in the ... ...
The juxtamembrane regions of human receptor tyrosine kinases exhibit conserved interaction sites with anionic lipids. - Oxford...
Receptor tyrosine kinases (RTKs) play a critical role in diverse cellular processes and their activity is regulated by lipids in the surrounding membrane, including PIP2 (phosphatidylinositol-4,5-bisphosphate) in the inner leaflet, and GM3 (monosialodihexosylganglioside) in the outer leaflet. However, the precise details of the interactions at the molecular level remain to be fully characterised. Using a multiscale molecular dynamics simulation approach, we comprehensively characterise anionic lipid interactions with all 58 known human RTKs. Our results demonstrate that the juxtamembrane (JM) regions of RTKs are critical for inducing clustering of anionic lipids, including PIP2, both in simple asymmetric bilayers, and in more complex mixed membranes. Clustering is predominantly driven by interactions between a conserved cluster of basic residues within the first five positions of the JM region, and negatively charged lipid headgroups. This highlights a conserved interaction pattern shared across the
If soil Indices* are below the target level the second section of the Calculator provides a guide to the quantity of nutrient which is likely to be required to correct the deficiency. This will vary according to the level of deficiency and the soil type. The quantity will usually be more than can reasonably be applied in one season, and the Calculator asks by how much and how quickly you want to correct the deficiency, i.e. over how many years. The desired improvement can be input by Index or more precisely by mg/litre as determined by soil analysis*. Once all relevant information has been input (for one or both nutrients) clicking on the Calculate button will provide a guide to the total quantity of nutrient(s) which will be required. The annual dressing is also shown, according to the timescale selected. The bottom line shows this annual deficiency-correcting application, together with the maintenance dressing. The cost of the nutrient(s) required to correct the deficiency should not be ...
U.S. fertilizer maker Mosaic Co (MOS.N) reported a smaller-than-expected quarterly profit on Tuesday, as higher sales volumes were offset by lower phosphate and potash prices.
The Report Global Potash Market Report: 2015 Edition provides information on pricing, market analysis, shares, forecast, and company profiles for key...
Western Potash Elects New Chairman of the Board and Receives Environmental Assessment Approval for Milestone Project Pilot Plant
VANCOUVER, BRITISH COLUMBIA--(Marketwired - Sept. 28, 2015) - Western Potash Corp. (TSX:WPX)(FRANKFURT:AHE) (the Western, the Company) is pleased to announce that subsequent to the closing of the strategic investment from Beijing Tairui Innovation Capital Management Ltd. (Tairui), announced September 16th of this year, Mr. Chang Xiaogang (Geoffrey) has been elected...
Sulphate of potash (also known as SOP) is widely used in the horticultural sector as well as organics to provide potassium for chloride-sensitive crops. It is largely inert and may be blended with virtually all other fertiliser products.
Potash Corp. lowered earnings guidance just a couple of weeks before its third quarter earnings release. That comes after dour comments from chief competitors Mosaic and Agrium . But don't
Slide Set: Introduction to Chemical Mixtures. A biologist must be able to work with and understand a variety of mixtures. Dr. David Caprette presents basic concepts and definitions, and the rationale behind descriptions of types of mixtures. Companion slide set for the video, Introduction to Chemical Mixtures.
Individual Experiments and Mini-Laboratory Courses for Cell Biology | Modern Biology Inc. Creative Experiments used in...
This mini program is composed of Experiments 1-3 from Modern Biologys Basic Program 3.. 1. Separating Molecules by Gel Filtration. Students fill their chromatographic columns with packing material and separate three colored molecules of known molecular weights as shown in the photograph below. The exercise illustrates how components of a complex mixture can be separated by chromatography and introduces the concept of the standard curve for determining the size of an unknown protein.. 2. The Molecular Weight of Hemoglobin. ...
In Canandaigua, New York, Geneva Schmidtka blends together a rich, cheesy sauce that showcases canned crab meat. The creamy mixture can be served with toast points for a special lunch or over chicken, rice or potatoes for a distinctive dinner.
Chemical Genetic Approach for Kinase‐Substrate Mapping by Covalent Capture of Thiophosphopeptides and Analysis by Mass...
Mapping kinase‐substrate interactions demands robust methods to rapidly and unequivocally identify substrates from complex protein mixtures
Chemical structure - K2SO4. Shipped in a resealable foil bag.. Potassium Sulfate has a wide variety of uses.. MSDS and Spec Sheets can be found here.. Please follow handling instructions. ...
(So named (Dutch: potasch, potash) in 1807 by Humphry Davy, who first isolated it from potash) A soft, silver-white, waxlike metallic chemic...
Dr. Ajay Deshpande - Book Appointment, Consult Online, View Fees, Contact Number, Feedbacks | Dentist in Hyderabad
Dr. Ajay Deshpande is a Dentist in Begumpet, Hyderabad. Book Appointment, Consult Online, View Doctor Fees, Contact Number, User Reviews and Ratings for Dr. Ajay Deshpande | Lybrate
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Methods, systems and other embodiments associated with upgrading heavy oil are presented. A method (900) of upgrading heavy oil by deasphalting includes mixing (902) an initial solvent with raw heavy oil to produce a mixed heavy oil. The mixed heavy oil is heated (904) to produce heated heavy oil. High pressure pulses are created (906) in the heated heavy oil to crack the heated heavy oil to produce a cracked oil with a lower viscosity than the raw heavy oil.
Dried Agaricus Blazei Murill specifications & features from suppliers/manufacturer Dried Agaricus Blazei specifications: 2.5cm up 2.0-2.5cm 1.5-2.0cm
Heavy Oil Hydrotreating Catalyst Global Market 2017 by Manufacturers - Dow, Mitsui Chemicals, Basf, Lanxess, DuPont |...
Global Heavy Oil Hydrotreating Catalyst Market 2017, presents a professional and in-depth study on the current state of the Heavy Oil Hydrotreating Catalyst market globally, providing basic overview of Heavy Oil Hydrotreating Catalyst market including Definitions, Classifications, Applications and Industry chain structure, Heavy Oil Hydrotreating Catalyst Market report provides development policies and plans are discussed as well as manufacturing processes and cost structures. Heavy Oil Hydrotreating Catalyst market size, share and end users are analyzed as well as segment markets by types, applications and companies.. Download Free Sample Report @ http://www.fiormarkets.com/report-detail/34066/request-sample. Global market research report of Heavy Oil Hydrotreating Catalyst 2017 mainly focuses on Production, means the output of Heavy Oil Hydrotreating Catalyst and Revenue, means the sales value of Heavy Oil Hydrotreating Catalyst in market ...
About Potash | North Atlantic Potash | Albany Project, Potash Joint Venture, Potash Exploration, Foam Lake
North Atlantic Potash is committed to exploration and mining activities in Saskatchewan that benefit all our stakeholders. A leading partner in the CanPacific Potash project.,
About Potash | North Atlantic Potash | Albany Project, Potash Joint Venture, Potash Exploration, Foam Lake
North Atlantic Potash is committed to exploration and mining activities in Saskatchewan that benefit all our stakeholders. A leading partner in the CanPacific Potash project.,
Proceedings | Free Full-Text | Microscale Gas Chromatography with Microsensor Array Detection: Challenges and Prospects
The capability to analyze complex mixtures of airborne volatile organic compounds (VOCs) at low concentrations; in situ; has implications for environmental monitoring; worker exposure assessment; biomedical diagnostics; and population security. Since standalone microsensor arrays lack this capability; upstream separation of mixture components; often preceded by preconcentration; is required. Although significant advances have been made via MEMS technologies in the development of microscale gas chromatographic (μGC) systems; many challenges remain. This presentation will review selected aspects of the state-of-the-art in μGC for VOC mixture analysis. Here; we emphasize our progress toward a wearable μGC prototype.
VPX Meltdown® significantly increases energy expenditure and fat oxidation without affecting hemodynamic variables in a...
VPX Meltdown®, increased REE significantly more than placebo at 45 minutes (2,079 ± 373 vs. 1,847 ± 340 kcal/day; p = 0.003) and 60 minutes (2,153 ± 403 vs. 1877 ± 314 kcal/day; p = 0.025) post-ingestion. Furthermore, REE 60 minutes post-exercise (two to three hours following supplement administration) was higher in the Meltdown® group (2,179 ± 386 vs. 1,913 ± 400; p = 0.1440). Moreover, over the course of the three hour evaluation period, area under the curve assessment demonstrated that EE was significantly increased with VPX Meltdown® compared to placebo (area: 9,925 ± 1,331 vs. 8,951 ± 2,961; p = 0.043) while RER was significantly less than placebo (area: 5.55 ± 0.61 vs. 5.89 ± 0.44; p = 0.002) following ingestion. HR and BP were not significantly affected prior to exercise with either supplement (p , 0.05) and the exercise-induced increases observed in HR and BP that decreased into recovery were not different between supplements (p , 0.05). ...
Many model-based clustering methods are based on a finite Gaussian mixture model. The Gaussian mixture model implies that the data scatter within each group is elliptically shaped. Hence non-elliptical groups are often modeled by more than one component, resulting in model over-fitting. An alternative is to use a mean-variance mixture of multivariate normal distributions with an inverse Gaussian mixing distribution (MNIG) in place of the Gaussian distribution, to yield a more flexible family of distributions. Under this model the component distributions may be skewed and have fatter tails than the Gaussian distribution. The MNIG based approach is extended to include a broad range of eigendecomposed covariance structures. Furthermore, MNIG models where the other distributional parameters are constrained is considered. The Bayesian Information Criterion is used to identify the optimal model and number of mixture components. The method is demonstrated on three sample data sets and a novel variation ...
The Bethune Potash project is being developed near Moose Jaw, Saskatchewan in Canada. Image courtesy of TUBS.
A solution mining method is applied at the Bethune potash mine. The process involves dissolving underground water-soluble minerals with water, commonly referred to as brine. The water is then extracted from the ground and the contained minerals are recovered from it.. This project involves two mining phases, primary and secondary. The primary method uses fresh water, which is injected into the ground through two boreholes. The fresh water is mixed with the potash-bearing salt rock. Two single circular caverns were formed, approximately 80m apart and 1,500m below the surface.. In the secondary phase, the mine uses a sodium chloride-saturated brine to selectively dissolve the potassium chloride from the walls and roof of the caverns. The sodium chloride solution is injected below the Esterhazy seam and the deposit will be solution-mined up to 3m thick horizontal layers.. The potash brine solution from the underground is transported to surface through two boreholes and processed further. The mine ...
JNE Welding can fabricated crystallization vessels for the potash industry. JNE has the experience and skills to meet your needs. JNE Weldings 77,000 square feet of fabrication shop allows it to fabricate large crystallization vessels with ease. We also provide on site installation and repair services for faster setup and recovery. With disciplined project management and scheduling processes, JNE provides accurate and timely project reporting ensuring the critical path is maintained and commitments for project delivery are met. Our experience working in the potash industry has allowed us to work with a variety of materials. Some of which, require very strict adherence to tight weld parameters. ...
Canadian Prime Minister Stephen Harpers administration has until Wednesday to decide whether to approve BHP Billiton Ltd.s $40 billion hostile bid for Potash Corp. of Saskatchewan Inc. The Conservative government is under pressure from provincial politicians to block the bid from Melbourne, Australia-based BHP, the worlds largest mining company. The federal review must weigh the governments policy of attracting foreign investment against the opposition to the proposed takeover of Potash, the worlds biggest producer of its namesake fertilizer.
Global X Fertilizers/Potash ETF (SOIL) Call Transcripts � Find company conference call transcripts for Global X Fertilizers/Potash ETF and all the companies you research at NASDAQ.com
[114 Pages Report] Check for Discount on United States Potash Fertilizers Market Report 2017 report by QYResearch Group. In this report, the United States Potash Fertilizers market is...
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Here is a recipe for a homemade liquid fertilizer shared by Dr. Heather Vallier. The mixture can be easily made in a blender and only require four ingredients. Because it includes ripe bananas which contain potassium, it is best for flowering plants. The mixture can be used every few months in the growing season. […]. ...
A Web-Based Graphical Interface To Build Heterogeneously Mixed Membrane Bilayers For The GROMACS Biomolecular Simulation Program. ...
A world-class SOP play with extraordinary promise, IC Potash nearing completion of Feasibility Study
Without question, Himmel and Co. have made significant progress on all key activities that advance the Ochoa SOP project; however, the Feasibility Study (which will contain final economic and technical data, along with definitive cost assessments) will enable to IC Potash to "continue negotiations" with various domestic and international institutions and strategic industry partners to fund the Ochoa SOP project. Yara International - the worlds largest distributor of all fertilizer products, based in Norway - made a $40 million investment in ICP in 2012 (Yara also has a seat on ICPs Board of Directors and an off-take agreement in place).. Since late last year, ICPs staff of technical professionals along with its team of more than 100 distinguished industry consultants has been working tirelessly on the completion of the Ochoa Project Feasibility Study. Yesterdays announcement also provided an operational update on pilot plant optimization tests, jurisdictional determination on water, water ...
Natural Formula Promotes Healthy, Productive Plants Product Description AGGRAND Natural Kelp and Sulfate of Potash 0-0-8 (NKP) is a liquid conce
Natural Formula Promotes Healthy, Productive Plants Product Description AGGRAND Natural Kelp and Sulfate of Potash 0-0-8 (NKP) is a liquid conce
Veolia Water Technologies will provide key processing technologies integrating HPD crystallisation systems designed to produce high-quality sulfate of potash.
Mosaic Co., the largest U.S. producer of potash fertilizer, said it plans to reduce output as low crop prices continue to erode farmer demand for agricultural products.
ABII (Abraxis Bioscience Inc), ACOR (Acorda Therapeutics Inc.), ADS:CA (Adaltis Inc.), AEZ:CA (Aeterna Zentaris Inc.), AFFY (Affymax Inc.), AGEN (Antigenics Inc.), AHX:CA (Adherex Technologies Inc.), ALNY (Alnylam Pharmaceuticals Inc.), ALTU (Altus Pharmaceuticals Inc.), ALXN (Alexion Pharmaceuticals Inc.), AMB:CA (Ambrilia Biopharma Inc.), AMGN (Amgen Inc.), AMLN (Amylin Pharmaceuticals Inc.), ANP:CA (Angiotech Pharm), AOB (American Oriental Bioengineering Inc.), APH:CA (Alda Pharmaceuticals Corp.), ARIA (ARIAD Pharmaceuticals Inc.), AVI:CA (Advitech Inc.), AXP:CA (Axcan Pharma), BCRX (BioCryst Pharmaceuticals Inc.), BIIB (Biogen Idec Inc), BMRN (BioMarin Pharmaceutical Inc.), BNC:CA (Bioniche Life J), BPAX (Biosante Pharmaceuticals), BVF:CA (Biovail Corp), CADX (Cadence Pharmaceuticals Inc.), CDG:CA (Chondrogene Ltd.), CEGE (Cell Genesys Inc.), CELG (Celgene Corp.), CEPH (Cephalon Inc.), CERS (Cerus Corp.), CGRB (Cougar Biotechnology Inc.), CHTP (Chelsea Therapeutics International Ltd.), CLDA ...
PLYMOUTH, Minn., Jan. 18, 2016 /PRNewswire/ -- Walt Precourt Named Senior Vice President - Phosphates; Bruce Bodine to Lead Mosaics Potash Business.
By Rod Nickel WINNIPEG, Manitoba, Oct 5 (Reuters) - Dwindling inventories of the crop nutrient potash held by Chinese buyers could lead to an earlier 2017 sa...
(For faster updates on individual market-movers, Eikon usersplease use search string STXBZ US; for the Day Aheadnewsletter, link.reuters.com/mex49s; for the Morning NewsCall newsletter, link.reuters.com/nex49s)U.S. stock indexes rose on Monday on Chinas move to boost itsslowing economy and higher oil prices, putting the S&P 500 ontrack to post its first monthly gains this year. The Dow Jonesindustrial average was up 0.25 percent at 16,682.23, theS&P 500 was up 0.27 percent at 1,953.26 and the NasdaqComposite was up 0.41 percent at 4,609.131.** FEDERAL-MOGUL HOLDINGS CORP, $7.24, +45.38 pctBillionaire Carl Icahns investment company offered to buythe 18 percent of the auto parts maker that it does not alreadyown for about $213 million. The offer values the company atabout $1.2 billion, based on its shares outstanding as on Sept.30.** INTREPID POTASH INC, $0.96, -56.76 pctThe miner said its auditor had expressed doubts about itsability to stay in business. The company, which reported itsthird straight
Company Name: Passport Potash Inc. (TSX:PPI), Stock Symbol: PPRTF, Industry: Mining/Resources, Total Posts: 315, Last Post: 8/20/2017 9:44:38 AM
The uncanny coincidences among the Meltdown and Spectre discoveries raise questions about bug collisions-and the safety of the NSAs hidden vulnerability collection.
Sharp increases in temperature driven by global warming are melting Chinas Himalayan glaciers, an impact that threatens habitats, tourism and economic
Charlie Sheen reveals all about THAT meltdown, his HIV secret, family and big screen comeback - Filey and Hunmanby Mercury
Hollywood bad boy Charlie Sheen has revealed big screen comeback plans after admitting for the first time that his public ‘meltdown’ was a result of dealing with his HIV secret.
In order to evaluate the impact of patching server against Spectre and Meltdown, we decided to run tests to make our own conclusion. See what we found!
See an archive of all meltdown stories published on the New York Media network, which includes NYMag, The Cut, Vulture, and Grub Street.
When Mommy is having a meltdown, but were still cute.... My toddler loves to go shopping with Mommy. Does Mommy always enjoy that experience? Umm....nope!! There are times when shopping with my beautiful children is pure bliss. We wander the aisles of the grocery & department stores, racking up compliments on how gorgeous and well…
Meltdown Games is raising funds for Gothic Doctor on Kickstarter! A card game where doctors treat the sick (and monstrous) and compete to become the newest partner on Londons Harley Street.
Optisol information about active ingredients, pharmaceutical forms and doses by Fischer Pharmaceuticals, Optisol indications, usages and related health products lists
Chrysler Pacifica Struts - 28 images - Sachs 174 Chrysler Pacifica 2007 Rear Shock Absorber, Sensen 174 Chrysler Pacifica 2006...
Chrysler Pacifica Struts - 28 images - Chrysler Pacifica Shock And Strut Set Parts View, 1pair Rear Hatch Lift Supports Shocks Struts Fits 2004, Kyb 4 Struts Shocks Awd Chrysler Pacifica 2004 2005 2006, Fcs 174 Chrysler Pacifica 2006 Front Complete Strut Assembly, Sachs 174 Chrysler Pacifica 2004 2008 Nivomat Rear Driver
Agaricus Blazei Murill 1000 mg - longevitate, imuno, cancer, Stimulant longevitate, imunostimulator, anticancerigen, epilepsie, sistem nervos. Extract concentrat 4:1, de calitate farmaceutica, conform normelor QCMS/GMP. In unele culturi, Agaricus este poreclita si Ciuperca lui Dumnezeu., Ciuperci terapeutice
Potassium alum or potash alum crystals grow very quickly and easily. If you color the crystals red you can get beautiful 'ruby' crystals.
Electrolytic solution: Broadly speaking, liquid mixtures can be classified as either solutions of electrolytes or solutions of nonelectrolytes. Electrolytes are substances that can dissociate into electrically charged particles called ions, while nonelectrolytes
Once prepared, the mixture can be used as both a marinade and a sauce. The fish or meat to be cooked is first allowed to sit in the sauce for a few minutes so the flavours can penetrate. If it is to be cooked on an open grill or broiler, the sauce is brushed or spooned over it several times during the cooking. If it is pan-fried, the sauce can be added to the pan to mingle with the cooking juices and be served as part of the dish ...
Small molecule bioanalytical quantitation can be used to measure the amount of a small molecule in complex protein mixtures, such as plasma, urine and cell extracts. LC-MS is performed using selected reaction monitoring (SRM) on an AB SCIEX 4000 QTRAP with samples ranging from clinical research to food and
High resolution two-dimensional gel electrophoresis is a very powerful biochemical tool for analysis of complex protein mixtures. In well defined situations, protein maps, obtained from tissue biopsies or biological fluids by this technique, can be automatically analyzed by computer. Some polypeptide patterns are the fingerprints of diseases. Applying clustering algorithm and learning techniques, the prototype expert system MELANIE recognized patterns and associated the correct diagnosis to the specific pattern.
801. Serum Proteins and the Western Press-Blot (EXP-801) | Modern Biology Inc. Creative Experiments used in teaching labs of...
Western blotting is one of the most powerful methods in molecular biology for identifying and characterizing specific proteins in complex protein mixtures. We have now streamlined western-blotting procedures so that the entire analysis can be performed during a single 3-hour, or two 2-hour laboratory sessions. In exercise 801, students use the procedure outlined below to identify albumin, transferrin and gamma globulins in serum and then to study the evolutionary relationships of albumin in vertebrates.. ...
Been reading this ! a Question is sulfate of potash the same as potassium thiosulfate Charles Cue Very different materials. Sulfate of potash...
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Red Team 2014 Spring Meltdown Chat Thread Week 5 (05/26-06/01) - 3 Fat Chicks on a Diet Weight Loss Community
Okee .. here we are 4 weeks down Hope everyone had a wonderful Memorial Day weekend that celebrated it and you are all safe and sound wherever you are
This is what you could have if you arent careful and eating enough! Yes, you heard me correctly, eating enough! Ive been assessing metabolism for 3 years now and have run over 400 assessments. What I have found to be the case, probably 90% of the time, is that people arent eating enough! My niche…
The beautifully sweet but brightly acidic flavor of a tomato picked fresh from the garden makes for a tasty treat. But in addition to their vibrancy and flavor, tomatoes-especially organic tomatoes-are packed with nutrition, including a variety of phytochemicals that boast a long list of health benefits ...
first major meltdown this week... | ConductDisorders - A soft place to land for battle weary parents.
Just when you think things are getting better... then the proverbial $h!t hits the fan. Last night easy child and difficult child asked to watch a movie. It was already...
We all knew this was coming. European officials have confirmed earlier reports that France and Italy will both see their credit ratings cut this afternoon by ratings agency Standard &
Just had a horrendous experience. Had an accident at home in the evening - lots of blood (head wound). Went to my local A&E as there are no alte
Today is the hottest day of the year to date, over 100 in my neighborhood. The stench from pigeon shit is unbelievable. I looked out my window to see hordes of pigeons under the tree and on the sidewalk. The sidewalk has more pigeon shit on it than I have seen since last year when…
The only thing worse than a belligerent drunk is being stuck on a plane with a belligerent drunk. Modern Familys Ryan Case explains.
I'm not Les Miserable any more: After that split from Amanda Holden and his meltdown on Big Brother, Les Dennis can smile again...
Eleven years ago Les Dennis appeared to be an emotional wreck during his appearance in Big Brother. But after meeting third wife Claire he has become a changed man.
Gambin Anna , Dutkowski Janusz , Karczmarski Jakub , Kluge Bogusław , Kowalczyk Krzysztof , Ostrowski Jerzy , Poznański Jarosław , Tiuryn Jerzy , Bakun M. , Dadlez Michał Lech , Automated reduction and interpretation of multidimensional mass spectra for analysis of complex peptide mixtures, International Journal of Mass Spectrometry, 2007, 260, s. 20-30 ...
Advanced methodological approach in determination of the heart rate deflection point: S.D<sub>max</sub> versus L.D<sub>max</sub...
Results: Downward inflection of HRDP was noticed in all subjects. Comparison of the S.Dmax and L.Dmax methods with the criterion method (lactate method) showed that while HRDP determined by the S.Dmax and lactate methods were not significantly different (167±8.83 vs. 168±8.17 b/min; P=0.86), significant difference emerged between determined HRDP by the L.Dmax and lactate methods (167±8.83 vs. 139.56±6.73 b/min; P£0.001). Bland-Altman plots revealed a good agreement between S.Dmax and lactate methods (95% CI=-5 to +3.6 b/min), while there is no agreement between L.Dmax and lactate method (95% CI=+4.9 to +71.3 b/min). Significant correlation was observed between the criterion and S.Dmax model (r=0.944) whereas there was no significant correlation between the criterion and L.Dmax model (r=0.158 ...
Thank you for your interest in spreading the word about Biochemical Journal.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Motor Trend reviews the 2004 Chrysler Pacifica where consumers can find detailed information on specs, fuel economy, transmission and safety. Find local 2004 Chrysler Pacifica prices online.
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
2018年1月2日にSituation Publishing系列のThe Registerが報じたニュースにインテルが1月3日に応じた発表によって、広く知られることになったモダンCPUのマイクロアーキテクチャが持つ投機的実行（Speculative Execution）機能を利用したセキュリティ攻撃Side Channel Analysis Exploit（通称MeltdownおよびSpectre）は、現在利用されている主要なCPUとソフトウェアが影響を受ける、過去に類を見ない広範囲な影響を及ぼすCPUハードウェアの脆弱性となった。. 米国CERTが報告しているCPUハードウェアの「Side-Channel ... ...
Heh i just started going into a tanning bed after gym workouts. Ive heard atomic meltdown is where its at so im planning on getting some sometime soon.
Difference Between Pure Substance and Mixture | Definition, Composition, Properties, Examples | clickspay.ru
What is the difference between Pure Substance and Mixture? A pure substance contains only one kind of compound.Mixtures are composed of several kinds of ..
George D. Kitas is the author of this article in the Journal of Visualized Experiments: A Methodological Approach to Non-invasive Assessments of Vascular Function and Morphology
Learn more about Pacifica Senior Living San Leandro and other senior living providers around San Leandro, CA. See reviews, prices, photos, services, amenities and more...
Global Fracking Fluid and Chemicals Market Product Type, Application And Specification And Forecast To 2021 | Medgadget
Global Fracking Fluid and Chemicals Market Fracking fluids are a complex mixture of chemicals, water, and sand. The composition of fracking fluids is uniqu
Also known as - Agaricus brasiliensis Japanese name - Himematsutake Portuguese name - Cogumela del sol English name - Royal/Sun Agaric Commonly known as A.blazei Murill (ABM), after a mushroom discovered in 1945 by the mycologist William A. Murrill growing on the lawn of his friend R.W.Blaze in Florida. Although one of the newest mushrooms recognised as having medicinal properties, A. blazei is rapidly becoming one of the most popular. In traditional medicine, this mushroom has been used to treat a wide variety of ailments including general physical and emotional stress, diabetes, high cholesterol and circulatory problems, osteoporosis, peptic ulcers and indigestion, to chronic hepatitis and cancer. The Agaricus Blazei Murill is bets known for generally strengthening the immune system and promoting cellular health. The active components are polysaccharides, and each vegtarian capsule contains a 30% strength standardised polysaccharide extract. Disclaimer: Active Health makes no health claims for any
TABLE-US-00002 TABLE 2 Example 5 P6 P7 Whether the product is a Mixture Whether the product is a Mixture compound having a single compound having a single composition or a mixture. composition or a mixture. Main component of mixture (i) (R13SiO3/2)8 Main component of mixture (i) (R14SiO3/2)8 (described in specification) (described in specification) m + n + p, and m, n, and p in (i) m + n + p = 8, and m = 0, m + n + p, and m, n, and p in (i) m + n + p = 8, and m = 8, main component of mixture n = 8, p = 0 main component of mixture n = 0, p = 0 Abundance of main 70 mass % or more Abundance of main 70 mass % or more (70-75%) component in mixture component in mixture Weight average molecular 1750 Weight average molecular 2600 weight (Mw) of mixture weight (Mw) of mixture Identi- Identification of presence of In 1H-NMR analysis, Identi- Reason for n = 0 In 1H-NMR analysis, fication epoxy the ratio of the epoxy fication (identification of absence of the ratio of the acryloyloxy group to the methylene ...
China 100% Natural Cordyceps Sinensis Extract Polysaccharides 40% - China Cordyceps Sinensis, Cordyceps Sinensis Extract
China 100% Natural Cordyceps Sinensis Extract Polysaccharides 40%, Find details about China Cordyceps Sinensis, Cordyceps Sinensis Extract from 100% Natural Cordyceps Sinensis Extract Polysaccharides 40% - Xi′an Tianrui Biotech Co., Ltd.
No effect of cordyceps sinensis supplementation on testosterone level and muscle strength in healthy young adults for...
TY - JOUR. T1 - No effect of cordyceps sinensis supplementation on testosterone level and muscle strength in healthy young adults for resistance training. AU - Hsu, C. C.. AU - Lin, Y. A.. AU - Su, B.. AU - Li, J. H.. AU - Huang, H. Y.. AU - Hsu, M. C.. PY - 2011. Y1 - 2011. N2 - The purpose of this study was to assess the effects of oral Cordyceps sinensis supplementation combined with resistance training in young male adults. A group of 16 subjects were randomly allocated to two groups (double blind) to receive either Cordyceps sinensis (CS; 2.4 g/day; n = 8) or a placebo (P; 2.4 g maltodextrin/day; n = 8) during eight weeks of resistance training. Exercises were performed for three sets of 3 to 5 repetitions at a mean training intensity of 80% of 1 repetition maximum (1RM). Before and after training, measurements were taken 1 RM to bench press, leg press, and seated rowing. The body composition, plasma testosterone levels, as well as serum concentrations of blood urea nitrogen, creatinine, ...
The upper critical solution temperature (UCST) or upper consolute temperature is the critical temperature above which the components of a mixture are miscible in all proportions. The word upper indicates that the UCST is an upper bound to a temperature range of partial miscibility, or miscibility for certain compositions only. For example, hexane-nitrobenzene mixtures have a UCST of 19 °C, so that these two substances are miscible in all proportions above 19 °C but not at lower temperatures. Examples at higher temperatures are the aniline-water system at 168 °C (at pressures high enough for liquid water to exist at that temperature), and the lead-zinc system at 798 °C (a temperature where both metals are liquid). A solid state example is the palladium-hydrogen system which has a solid solution phase (H2 in Pd) in equilibrium with a hydride phase (PdHn) below the UCST at 300 °C. Above this temperature there is a single solid solution phase. In the phase diagram of the mixture components, the ...
In vivo and in vitro stimulatory effects of Cordyceps sinensis on testosterone production in mouse Leydig cells Hsu CC, Huang YL, Tsai SJ, Sheu CC, Huang BM. Source Department of Cell Biology and Anatomy, College of Medicine, National Cheng Kung University, 1 University Road, 701 Tainan, Taiwan. Abstract The in vivo and in vitro effects…
Cordyceps Sinensis CS4- The Most Potent in the World | Medicinal Mushrooms | Health Benefits of Medicinal Mushrooms
Our Cordyceps Sinensis are the most potent mushroom extract supplements in the world because of our patent pending hybridization process. We are the only producer in the world of the super potent Cordyceps sinensis Alohaensis hybrid strain.
Thermo Scientific™ LTQ XL™ ion trap LC-MS mass spectrometer delivers high-sensitivity MSn. Performance to generate extensive structural information for routine proteomics and metabolism. applications. Its high-capacity 2D linear ion trap configuration with powerful software is a complete. solution for structural elucidation questions. The LTQ XL MS offers multiple dissociation techniques,. PQD, ETD and CID.. ...
The SALMFamides are a family of neuropeptides that act as muscle relaxants in echinoderms. Two types of SALMFamides have been identified: L-type (e.g. the starfish neuropeptides S1 and S2) with the C-terminal motif LxFamide (x is variable) and F-type with the C-terminal motif FxFamide. In the sea urchin Strongylocentrotus purpuratus (class Echinoidea) there are two SALMFamide genes, one encoding L-type SALMFamides and a second encoding F-type SALMFamides, but hitherto it was not known if this applies to other echinoderms. Here we report the identification of SALMFamide genes in the sea cucumber Apostichopus japonicus (class Holothuroidea) and the starfish Patiria miniata (class Asteroidea). In both species there are two SALMFamide genes: one gene encoding L-type SALMFamides (e.g. S1 in P. miniata) and a second gene encoding F-type SALMFamides plus one or more L-type SALMFamides (e.g. S2-like peptide in P. miniata). Thus, the ancestry of the two SALMFamide gene types traces back to the common ancestor of
Structural characterization of multibranched oligosaccharides from seal milk by a combination of off-line high-performance...
A complex mixture of diverse oligosaccharides related to the carbohydrates in glycoconjugates involved in various biological ... abstract = "A complex mixture of diverse oligosaccharides related to the carbohydrates in glycoconjugates involved in various ... N2 - A complex mixture of diverse oligosaccharides related to the carbohydrates in glycoconjugates involved in various ... AB - A complex mixture of diverse oligosaccharides related to the carbohydrates in glycoconjugates involved in various ...https://pure.fujita-hu.ac.jp/en/publications/structural-characterization-of-multibranched-oligosaccharides-fro
Complex Mixtures - Phenotypes | CTD
Ozone results in increased oxidation of Vehicle Emissions] which results in increased chemical synthesis of Aerosols] which results in increased DNA damage response, detection of DNA damage ...http://ctd.mdibl.org/detail.go?type=chem&acc=D045424&view=phenotype
Complex Mixtures - Exposure Studies | CTD
The NHS found complex patterns of association between reported resource uses and cancer and thyroid-, reproductive-, metabolic ...http://ctd.mdibl.org/detail.go?type=chem&acc=D045424&view=expStudies
Soil signature simulation of complex mixtures and particle size distributions
... Tyler Carson, Charles M. Bachmann, Carl ... Tyler Carson, Charles M. Bachmann, Carl Salvaggio, "Soil signature simulation of complex mixtures and particle size ... "Soil signature simulation of complex mixtures and particle size distributions," Optical Engineering 54(9), 094103 (10 September ... It also confirms the suggestion that directional reflectance signatures can be defined by intimate mixtures that depend on pore ...https://www.spiedigitallibrary.org/journals/optical-engineering/volume-54/issue-09/094103/Soil-signature-simulation-of-complex-mixtures-and-particle-size-distributions/10.1117/1.OE.54.9.094103.full?SSO=1
Treatment of Complex Mixtures | Research Project Database | Grantee Research Project | ORD | US EPA
Treatment of Complex Mixtures. EPA Grant Number: R825689C035. Subproject: this is subproject number 035 , established and ... Title: Treatment of Complex Mixtures. Investigators: Reinhard, Martin , Roberts, Paul V. Institution: Stanford University EPA ... R825689C035 Treatment of Complex Mixtures. R825689C036 Oxidation of Chlorinated Solvents by Methanotrophs. R825689C037 ... complex mixtures, Data Evaluation System for Organic Compounds (DESOC), physico-chemical properties, hazardous waste, treatment ...https://cfpub.epa.gov/ncer_abstracts/INDEX.cfm/fuseaction/display.abstractDetail/abstract/2010
Processing complex mixtures of intact proteins for direct analysis by mass spectrometry. - PubMed - NCBI
Processing complex mixtures of intact proteins for direct analysis by mass spectrometry.. Meng F1, Cargile BJ, Patrie SM, ... fractionation illustrated by transforming thousands of intact proteins from Saccharomyces cerevisiae to mixtures of 5-20 ...https://www.ncbi.nlm.nih.gov/pubmed/12141648?dopt=Abstract
NIOSHTIC-2 Publications Search - 00227652 - DNA adducts and related biomarkers in assessing the risk of complex mixtures.
... particularly of complex mixtures. The findings of recent studies which assessed macromolecular adducts formed by carcinogens ... Genetic toxicology of complex mixtures. Waters MD, Daniel FB, Lewtas J, Moor MM, Nesnow S, eds. New York: Plenum Press, ... An overview was included of recent studies involving complex mixtures. The authors conclude that these early studies are ... DNA adducts and related biomarkers in assessing the risk of complex mixtures.. ...https://www.cdc.gov/niosh/nioshtic-2/00227652.html
Detecting Nitrous Oxide in Complex Mixtures Using FTIR Spectroscopy: Silage Gas
In this work, we demonstrate the use of Fourier Transform Infrared (FTIR) spectroscopy to analyze N2O in the complex mixture of ... FTIR spectroscopy was used to analyze N2O in a complex gas mixture produced in corn silage. The corn silage was made in ... In this work, we demonstrate the use of Fourier Transform Infrared (FTIR) spectroscopy to analyze N2O in the complex mixture of ... Zhao, Y., Wexler, A.S., Hase, F., Pan, Y. and Mitloehner, F.M. (2016) Detecting Nitrous Oxide in Complex Mixtures Using FTIR ...https://file.scirp.org/Html/3-6703152_71831.htm
The identification of lower peptides in complex mixtures | Biochemical Journal
The identification of lower peptides in complex mixtures. R. Consden, A. H. Gordon, A. J. P. Martin ... The identification of lower peptides in complex mixtures Message Subject (Your Name) has forwarded a page to you from ...http://www.biochemj.org/content/41/4/590
Combining Passive Sampling with Toxicological Characterization of Complex Mixtures of Pollutants from the Aquatic Environment |...
... the transfer of these mixtures into bioassays, and their related toxicological... ... The combination of polymer-based passive sampling to collect complex environmental mixtures of pollutants, ... The combination of polymer-based passive sampling to collect complex environmental mixtures of pollutants, the transfer of ... Combining Passive Sampling with Toxicological Characterization of Complex Mixtures of Pollutants from the Aquatic Environment. ...https://link.springer.com/chapter/10.1007/10_2015_5014
Unresolved complex mixture - Wikipedia
Unresolved complex mixture (also UCM or hump) is a feature frequently observed in gas chromatographic (GC) data of crude oils ... The use of GC×GC for the characterization of complex petrochemical mixtures has been extensively reviewed. Most research into ... Analysis of the hydrocarbon fraction of crude oils by gas chromatography (GC) reveals a complex mixture containing many ... Unresolved Complex Mixtures of Aromatic Hydrocarbons: Thousands of Overlooked Persistent, Bioaccumulative, and Toxic ...https://en.wikipedia.org/wiki/Unresolved_complex_mixture
Multiple displacement amplification for complex mixtures of DNA fragments | BMC Genomics | Full Text
The desired quantity and quality are often hard to obtain when target DNA is composed of complex mixtures of relatively short ... Here, we sought to develop a method to representatively amplify such complex mixtures by converting them to long linear and ... We believe that this method allows for generation of abundant amounts of good quality genetic material from a complex mixture ... Amplification of a complex mixture of relatively short DNA fragments, derived from mini scale experiments in chromatin ...https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-9-415
Project: Interactions between PAHs in complex mixtures and toxicological effects | Institute of Environmental Medicine |...
Our aim is to improve the risk assessment of complex environmental mixtures. ... The methods commonly used for assessing the toxicity of complex environmental mixtures probably significantly underestimate the ... The goal of this project is to investigate the harmful effects of exposure to complex mixtures of PAHs and other environmental ... Persistent activation of DNA damage signaling in response to complex mixtures of PAHs in air particulate matter.. Jarvis I, ...https://ki.se/en/imm/project-interactions-between-pahs-in-complex-mixtures-and-toxicological-effects
Structural Analysis of Glycosylated Peptides in Complex Mixtures with ,,, Ion Trap MSn ( Structural Analysis of...
Complex,Mixtures,with,,,,,,,,,,,,Ion,Trap,MSn,biological,advanced biology technology,biology laboratory technology,biology ... Structural Analysis of Glycosylated Peptides in Complex Mixtures with Ion Trap MS n Shiaw-Lin Wu Pavel Bondarenko Tom Shaler ... As would be expected from such a complex mixture, a number of co-eluting ions were observed. However, the triply-charged 211- ... Structural Analysis of Glycosylated Peptides in Complex Mixtures with Ion Trap MSn. Shiaw-Lin Wu, Pavel Bondarenko, Tom Shaler ...http://www.bio-medicine.org/biology-technology/Structural-Analysis-of-Glycosylated-Peptides-in-Complex-Mixtures-with--0D-0A-0A--------Ion-Trap-MSn-732-1/
Identification of Proteins in Complex Mixtures Using Liquid Chromatography and Mass Spectrometry - Current Protocols
Basic Protocol 3: Multidimensional Protein Identification Technology for Analyzing Complex Mixtures. Materials * Microcapillary ... Basic Protocol 3: Multidimensional Protein Identification Technology for Analyzing Complex Mixtures. *Basic Protocol 4: ... Identification of Proteins in Complex Mixtures Using Liquid Chromatography and Mass Spectrometry. ... Proteomics: The move to mixtures. J. Mass Spectrom. 36:1083‐1091. Santoni, V., Malloy, M., and Rabilloud, T. 2000. Membrane ...http://www.currentprotocols.com/WileyCDA/CPUnit/refId-cb0506.html
New mass spectrometry method for characterisation of the most challenging complex mixtures | Spectroscopy Europe/Asia
Amongst the range of such samples, petroleum is considered one of natures most complex mixtures. As a result, there is a ... With the flexibility of the method, it is also suitable for the analysis of other complex mixtures and challenging samples, ... New mass spectrometry method for characterisation of the most challenging complex mixtures. ... New mass spectrometry method for characterisation of the most challenging complex mixtures ...https://www.spectroscopyeurope.com/article/new-mass-spectrometry-method-characterisation-most-challenging-complex-mixtures
Structure and Modeling of Complex Petroleum Mixtures | SpringerLink
Molecular-Level Composition and Reaction Modeling for Heavy Petroleum Complex System Zhen Hou, Linzhou Zhang, Scott R. Horton, ... Catalyzed Oxidation for Petroleum Heavy Petroleums Petroleum Asphaltenes Petroleum Complex System Petroleum Related ...https://link.springer.com/book/10.1007/978-3-319-32321-3
Challenges in analysis of complex natural mixtures Faraday Discussion
These systems are generally classed as "complex mixtures" or "unresolved complex mixtures (UCM)", emphasising our current ... This meeting will discuss a vision for developing the field of analysis of complex mixtures. It will be unique in bringing ... Challenges in analysis of complex natural mixtures Faraday Discussion 13 - 15 May 2019, Edinburgh, United Kingdom ... For the most part, people who work on the analysis of complex mixtures are driving the progress in exploiting new methodologies ...http://www.rsc.org/events/detail/29574/challenges-in-analysis-of-complex-natural-mixtures-faraday-discussion/bursaries
Challenges in analysis of complex natural mixtures Faraday Discussion
This meeting will discuss a vision for developing the field of analysis of complex mixtures.. It will be unique in bringing ... We invite you to join us to discuss the topic of Challenges in analysis of complex natural mixtures and make your contribution ... Chair, Challenges in analysis of complex natural mixtures. Caring responsibilities. The RSC is keen to encourage and enable as ... Challenges in analysis of complex natural mixtures Faraday Discussion 13 - 15 May 2019, Edinburgh, United Kingdom ...http://www.rsc.org/events/detail/29574/challenges-in-analysis-of-complex-natural-mixtures-faraday-discussion/venue
Tumour promotion induction by complex mixtures of 2-4 and 0-1 ortho polychlorinated biphenyls in female sprague Dawley rats.
NIOSHTIC-2 Publications Search - 20025740 - Quantitating absorption of complex chemical mixtures.
Exposure to complex mixtures of chemicals is the norm in most of these settings. Although the mechanism of absorption of a ... Exposure to complex mixtures of chemicals is the norm in most of these settings. Although the mechanism of absorption of a ... Mixture component interactions are quantitated as a Mixture Factor that is related to certain solution properties of the ... A correlation between the straltum corneum/mixture partition coefficient and ultimate dermal absorption across mixtures was ...https://www.cdc.gov/niosh/nioshtic-2/20025740.html
Pulmonary function in normal and elastase-treated hamsters exposed to a complex mixture of olefin-ozone-sulfur dioxide reaction...
Title: Pulmonary function in normal and elastase-treated hamsters exposed to a complex mixture of olefin-ozone-sulfur dioxide ... Technical Report: Pulmonary function in normal and elastase-treated hamsters exposed to a complex mixture of olefin-ozone- ... or to the complex by-products from a dark-phase-reaction mixture of trans-2-butene, ozone, and sulfur dioxide (MIX). Lung- ...https://www.osti.gov/scitech/biblio/7090877
IJERPH | Free Full-Text | Cytological and Biochemical Effects of St. John's Wort Supplement (A Complex Mixture of St. John's...
Johns wort supplement (SJWS) composed of an herbal mixture of St. Johns Wort (SJW), Rosemary (RM) and Spirulina (SP) is used ... Johns Wort Supplement (A Complex Mixture of St. Johns Wort, Rosemary and Spirulina) on Somatic and Germ Cells of Swiss Albino ... Johns Wort Supplement (A Complex Mixture of St. Johns Wort, Rosemary and Spirulina) on Somatic and Germ Cells of Swiss Albino ... Johns Wort Supplement (A Complex Mixture of St. Johns Wort, Rosemary and Spirulina) on Somatic and Germ Cells of Swiss Albino ...http://www.mdpi.com/1660-4601/5/5/408
Toxicological risk assessment of complex mixtures through the WTox model
... Otro titulo: Avaliaçao do risco toxicológico de ... Toxicological risk assessment of complex mixtures through the WTox model. Mostrar el registro completo del ítem ... Matias, WG.; Flohr, L. (2015). Toxicological risk assessment of complex mixtures through the WTox model. Modelling in Science ... Toxicological risk assessment of complex mixtures through the WTox model. RiuNet: Repositorio Institucional de la Universidad ...https://riunet.upv.es/handle/10251/70004
British Library EThOS: Bioremediation of a former manufactured gas plants (FMGP) site contaminated with a complex mixture of...
Bioremediation of a former manufactured gas plants (FMGP) site contaminated with a complex mixture of heavy metals, organic and ... This study investigated the potential treatability of a representative soil sample, holding a complex mixture of metals, ...http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.502359
Mass spectrometryPeptidesProtein mixturesConstituentsToxicologicalProteinsToxicityPollutantsContaminantsExposureBiologicalCrude oilsCharacterizationSoilBioassaysSubstancesCompositionGeneticMoleculesMolecularInteractionsSpectroscopyEnvironmental mixtureDependComponentsRiskMethodAnalysis of complexChallengesStudiesApproachTechniquesCancerHumanReactionSystemsSamplesPresentTechniqueDataAbility
- Processing complex mixtures of intact proteins for direct analysis by mass spectrometry. (nih.gov)
- Based upon a combination of custom experiments and an in-house data processing algorithm, we used Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) to successfully analyse a non-distillable fraction of a heavy petroleum sample, representing one of the most complex mixtures investigated to date. (spectroscopyeurope.com)
- Ultrahigh resolution mass spectrometry, offering resolving power in the region of 10 5 -10 6 FWHM and sub part-per-million mass accuracy, is perhaps the only analytical technique able to separate and assign individual compositions in complex mixtures such as crude oils. (spectroscopyeurope.com)
- The techniques best positioned to tackle such mixtures experimentally include mass spectrometry, chromatography, NMR spectroscopy, or new alternative techniques, including combinations of the above methods. (rsc.org)
- High-resolution mass spectrometry is one of the most promising approaches to tackle the issues of structure determination of molecules locked in complex mixtures. (rsc.org)
- Quantification of constituents in areal and intimate binary mixtures of. (spiedigitallibrary.org)
- The authors conclude that these early studies are encouraging in that macromolecular adducts and related biomarkers can ultimately be useful in identifying the operational carcinogenic constituents of complex mixtures and in estimating whether their effect is additive or interreactive. (cdc.gov)
- These can be broadly divided according to the molecular sizes of their constituents, into mixtures of small or large molecules. (rsc.org)
- The combination of polymer-based passive sampling to collect complex environmental mixtures of pollutants, the transfer of these mixtures into bioassays, and their related toxicological characterization is still in its infancy. (springer.com)
- Second, the toxicological characterization of samples using bioassays is complementary to chemical (target) analysis within environmental monitoring because it captures all chemicals exerting the same mode of toxic action and acting jointly in mixtures, thus providing a comprehensive picture of their overall combined effects. (springer.com)
- Jahnke A, Witt G, Schäfer S, Haase N, Escher BI (2015) Combining passive sampling with toxicological characterization of complex mixtures of pollutants from the aquatic environment. (springer.com)
- We describe an approach for the accurate quantification and concurrent sequence identification of the individual proteins within complex mixtures. (nih.gov)
- Here we describe a high-throughput proteomic approach that enables simultaneous identification of SNO-Cys sites and their cognate proteins in complex biological mixtures. (pnas.org)
- Given this knowledge gap, we sought to develop a method that enables unbiased, facile, and high-throughput specification of SNO-Cys sites on NO-regulated target proteins in complex biological samples. (pnas.org)
- The goal of this project is to investigate the harmful effects of exposure to complex mixtures of PAHs and other environmental pollutants, and to improve the scientific base for risk assessment of human exposure to complex environmental mixtures. (ki.se)
- Our hypothesis is that synergistic effects between different PAHs and other pollutants in complex mixtures represent a major carcinogenic effect and there is an urgent need to include these interactions in health risk assessment. (ki.se)
- Jahnke A, Mayer P, Schäfer S, Witt G, Haase N, Escher BI (2016) Strategies for transferring mixtures of organic contaminants from aquatic environments into bioassays. (springer.com)
- This study investigated the potential treatability of a representative soil sample, holding a complex mixture of metals, organic and inorganic contaminants, from the site of a Former Manufactured Gas Plant (FMGP) using a combination of soil washing technique and bioremediation. (bl.uk)
- Exposure to complex mixtures of chemicals is the norm in most of these settings. (cdc.gov)
- DNA damage and epigenetic alteration in soybean farmers exposed to complex mixture of pesticides Benedetti, Danieli;Alderete, Barbara Lopes;de Souza, Claudia Telles;Dias, Johnny Ferraz;Niekraszewicz, Liana;Cappetta, Mónica;Martínez-López, Wilner;Silva, Juliana Da 2018-01-01 00:00:00 Abstract Exposure to pesticides can trigger genotoxic and mutagenic processes through different pathways. (deepdyve.com)
- Considering that there are few evaluations of soybean farmers, the aim of this study was to assess the effects of human exposure to complex mixtures of pesticides. (deepdyve.com)
- These data indicate that persistent genetic instability associated with hypermethylation of DNA in soybean workers after long-term exposure to a low-level to pesticides mixtures may be critical for the development of adverse health effects such as cancer. (deepdyve.com)
- This chapter critically evaluated the role of biological markers and molecular epidemiology in the risk management of environmental carcinogens, particularly of complex mixtures. (cdc.gov)
- Furthermore, the biological activity of a complex mixture cannot be reliably predicted from knowledge of its components. (worldcat.org)
- On the other hand, bioassays alone cannot tell us which components of complex mixtures are responsible for the biological activity detected. (worldcat.org)
- Thus, cost effectiveness and technical feasibility dictate stepwise and perhaps iterative application -of both chemical and biological methods in evaluating the health effects of complex environmental mixtures. (worldcat.org)
- Unresolved complex mixture (also UCM or hump) is a feature frequently observed in gas chromatographic (GC) data of crude oils and extracts from organisms exposed to oil. (wikipedia.org)
- Heavy crude oils are extremely complex and most conventional analytical techniques do not offer the level of performance required to provide sufficiently detailed molecular insights into crude oil behaviour under upgrading conditions. (spectroscopyeurope.com)
- The use of GC×GC for the characterization of complex petrochemical mixtures has been extensively reviewed. (wikipedia.org)
- This model provides validation for a phenomenological trade space between density and particle size distribution in complex, heterogeneous soil mixtures. (spiedigitallibrary.org)
- Tyler Carson , Tyler Carson, Charles M. Bachmann , Charles M. Bachmann, Carl Salvaggio , Carl Salvaggio, } "Soil signature simulation of complex mixtures and particle size distributions," Optical Engineering 54(9), 094103 (10 September 2015). (spiedigitallibrary.org)
- Food and beverages are extremely complex mixtures of substances that upon interaction with thousands of taste receptors on our tongue send a cascade of signals to our brain to create our perception of taste. (carlsbergfondet.dk)
- The UTOC was evaluated using a complex mixture of soluble and non-soluble substances and verified with an UVCB (vegetal extract). (rsc.org)
- The composition of the chemical mixture changes from the water phase to the passive sampling material because of kinetic effects and polymer/water partition coefficients which depend on the chemicals' hydrophobicity. (springer.com)
- One of the main advantages is the very high separation power, making the technique ideal for unravelling the composition of complex mixtures. (wikipedia.org)
- Genetic toxicology of complex mixtures. (cdc.gov)
- We believe that this method allows for generation of abundant amounts of good quality genetic material from a complex mixture of short DNA fragments, which can be further used in high throughput genetic analysis. (biomedcentral.com)
- Abundant amounts and good quality of amplified material are required for high throughput analysis of this kind of complex genetic material. (biomedcentral.com)
- Structure determination of molecules contained within unresolved complex mixtures represents an unsolved question that continues to challenge physical and analytical chemistry. (rsc.org)
- man-made mixtures of small molecules such as food, beverages or plant extracts. (rsc.org)
- This meeting is for established scientists, post-graduate students and industrial researchers interested in the structure determination of molecules contained within unresolved complex mixtures. (rsc.org)
- However, their sensing strategy will not use protein receptors but rather more than 10 16 free-floating DNA molecules folded into a complex set of 3D structures (2). (carlsbergfondet.dk)
- The disadvantages and limitations of biomarkers were that most lack adequate validation, and that the molecular epidemiological studies are complex and resource intensive. (cdc.gov)
- The authors encourage the use of well designed molecular epidemiological studies in human populations with model exposures to single agents and to complex mixtures in order to gain the most from the use of these markers. (cdc.gov)
- Can we unravel the molecular structures in complex mixtures by atomic force microscopy by "seeing", rather than interpreting the spectroscopic data? (rsc.org)
- A modified LFER model based on molecular descriptors of the penetrants and physical properties of the mixtures was formulated. (cdc.gov)
- Interactions between polycyclic aromatic hydrocarbons in complex mixtures and implications for cancer risk assessment. (ki.se)
- Our group has previously studied the nature of chemical interactions within a mixture that could modulate absorption across the skin. (cdc.gov)
- The objective of this present grant was to extend the analysis of chemical mixture interactions that affect percutaneous absorption to define the physical chemical characteristics of the mixture that allow significant mixture interactions to be detected. (cdc.gov)
- Statistical techniques were used to define significant mixture interactions. (cdc.gov)
- Mixture component interactions are quantitated as a Mixture Factor that is related to certain solution properties of the mixture components. (cdc.gov)
- In this work, we demonstrate the use of Fourier Transform Infrared (FTIR) spectroscopy to analyze N 2 O in the complex mixture of gases produced during the early phase of the silage making process. (scirp.org)
- The present paper demonstrates that FTIR (Fourier Transform Infrared) spectroscopy can be used to measure N 2 O concentration in the complex mixture that comprises silage gas, because some of the N 2 O absorption peaks are isolated from other gas absorptions in the FTIR spectra. (scirp.org)
- This chapter gives an overview of what has been carried out in this research area, focusing on opportunities and challenges, and points out desirable future developments with a focus on the importance of choosing a suitable combination of sampling and dosing to transfer (or re-establish) the environmental mixture into the bioassay. (springer.com)
- It also confirms the suggestion that directional reflectance signatures can be defined by intimate mixtures that depend on pore spacing. (spiedigitallibrary.org)
- Bacterial degradation of hydrocarbons is complex and will depend on environmental conditions (e.g. aerobic or anaerobic, temperature, nutrient availability, available species of bacteria etc. (wikipedia.org)
- These systems are generally classed as "complex mixtures" or "unresolved complex mixtures (UCM)", emphasising our current inability to separate their individual components. (rsc.org)
- This model resulted in better correlations (R2 of 0.76 versus 0.58) to absorption in both porcine skin model systems than was seen when a factor to account for mixture components was not included. (cdc.gov)
- Dermal absorption of toxicologically relevant compounds can be predicted using generally accepted QSPR equations based on LFER principles if the presence of mixture components are accounted for in a modified equation. (cdc.gov)
- By selecting the subclass of modules that can bind to the components in a particular food mixture and subsequently characterise them Kjems and his colleagues hope to create a "picture" of the ingredients - very similar to the principle applied by our brain. (carlsbergfondet.dk)
- Here, we sought to develop a method to representatively amplify such complex mixtures by converting them to long linear and circular concatamers, from minute amounts of starting material, followed by phi29-based multiple displacement amplification. (biomedcentral.com)
- The first step in the original biotin-switch method is methylthiolation of all free Cys-thiols in a protein mixture, followed by selective reduction of S-NO bonds, thereby generating a new unmodified thiol at each former SNO-Cys site. (pnas.org)
- For the most part, people who work on the analysis of complex mixtures are driving the progress in exploiting new methodologies and their creative combinations. (rsc.org)
- This session will explore how chemometrics can assist all other techniques in the analysis of complex mixtures, where extracting information by data-driven analysis is a necessity. (rsc.org)
- This meeting will discuss a vision for developing the field of analysis of complex mixtures. (rsc.org)
- We invite you to join us to discuss the topic of Challenges in analysis of complex natural mixtures and make your contribution to this cutting-edge dialogue alongside leaders in this field. (rsc.org)
- During the course of our research within this field, we have developed an approach for the characterisation of the most challenging complex mixtures. (spectroscopyeurope.com)
- Close examination of these data suggested that such effects may be predictable from the properties of the mixture in which the chemical was dosed. (cdc.gov)
- In conclusion, these data clearly demonstrate that mixture effects of compound absorption are reproducible across mixtures and compound classes. (cdc.gov)