Complement Factor D: A serum protein which is important in the ALTERNATIVE COMPLEMENT ACTIVATION PATHWAY. This enzyme cleaves the COMPLEMENT C3B-bound COMPLEMENT FACTOR B to form C3bBb which is ALTERNATIVE PATHWAY C3 CONVERTASE.Ecchymosis: Extravasation of blood into the skin, resulting in a nonelevated, rounded or irregular, blue or purplish patch, larger than a petechia.Complement Hemolytic Activity Assay: A screening assay for circulating COMPLEMENT PROTEINS. Diluted SERUM samples are added to antibody-coated ERYTHROCYTES and the percentage of cell lysis is measured. The values are expressed by the so called CH50, in HEMOLYTIC COMPLEMENT units per milliliter, which is the dilution of serum required to lyse 50 percent of the erythrocytes in the assay.Complement Pathway, Alternative: Complement activation initiated by the interaction of microbial ANTIGENS with COMPLEMENT C3B. When COMPLEMENT FACTOR B binds to the membrane-bound C3b, COMPLEMENT FACTOR D cleaves it to form alternative C3 CONVERTASE (C3BBB) which, stabilized by COMPLEMENT FACTOR P, is able to cleave multiple COMPLEMENT C3 to form alternative C5 CONVERTASE (C3BBB3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.Complement Factor H: An important soluble regulator of the alternative pathway of complement activation (COMPLEMENT ACTIVATION PATHWAY, ALTERNATIVE). It is a 139-kDa glycoprotein expressed by the liver and secreted into the blood. It binds to COMPLEMENT C3B and makes iC3b (inactivated complement 3b) susceptible to cleavage by COMPLEMENT FACTOR I. Complement factor H also inhibits the association of C3b with COMPLEMENT FACTOR B to form the C3bB proenzyme, and promotes the dissociation of Bb from the C3bBb complex (COMPLEMENT C3 CONVERTASE, ALTERNATIVE PATHWAY).Complement Factor B: A glycine-rich, heat-labile serum glycoprotein that contains a component of the C3 CONVERTASE ALTERNATE PATHWAY (C3bBb). Bb, a serine protease, is generated when factor B is cleaved by COMPLEMENT FACTOR D into Ba and Bb.Complement Factor I: A plasma serine proteinase that cleaves the alpha-chains of C3b and C4b in the presence of the cofactors COMPLEMENT FACTOR H and C4-binding protein, respectively. It is a 66-kDa glycoprotein that converts C3b to inactivated C3b (iC3b) followed by the release of two fragments, C3c (150-kDa) and C3dg (41-kDa). It was formerly called KAF, C3bINF, or enzyme 3b inactivator.Complement C3: A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase.Complement Activation: The sequential activation of serum COMPLEMENT PROTEINS to create the COMPLEMENT MEMBRANE ATTACK COMPLEX. Factors initiating complement activation include ANTIGEN-ANTIBODY COMPLEXES, microbial ANTIGENS, or cell surface POLYSACCHARIDES.Complement System Proteins: Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).Complement C3b: The larger fragment generated from the cleavage of COMPLEMENT C3 by C3 CONVERTASE. It is a constituent of the ALTERNATIVE PATHWAY C3 CONVERTASE (C3bBb), and COMPLEMENT C5 CONVERTASES in both the classical (C4b2a3b) and the alternative (C3bBb3b) pathway. C3b participates in IMMUNE ADHERENCE REACTION and enhances PHAGOCYTOSIS. It can be inactivated (iC3b) or cleaved by various proteases to yield fragments such as COMPLEMENT C3C; COMPLEMENT C3D; C3e; C3f; and C3g.Complement Activating Enzymes: Enzymes that activate one or more COMPLEMENT PROTEINS in the complement system leading to the formation of the COMPLEMENT MEMBRANE ATTACK COMPLEX, an important response in host defense. They are enzymes in the various COMPLEMENT ACTIVATION pathways.Complement C2: A component of the CLASSICAL COMPLEMENT PATHWAY. C2 is cleaved by activated COMPLEMENT C1S into COMPLEMENT C2B and COMPLEMENT C2A. C2a, the COOH-terminal fragment containing a SERINE PROTEASE, combines with COMPLEMENT C4B to form C4b2a (CLASSICAL PATHWAY C3 CONVERTASE) and subsequent C4b2a3b (CLASSICAL PATHWAY C5 CONVERTASE).Complement C3b Inactivator Proteins: Endogenous proteins that inhibit or inactivate COMPLEMENT C3B. They include COMPLEMENT FACTOR H and COMPLEMENT FACTOR I (C3b/C4b inactivator). They cleave or promote the cleavage of C3b into inactive fragments, and thus are important in the down-regulation of COMPLEMENT ACTIVATION and its cytolytic sequence.Complement C4: A glycoprotein that is important in the activation of CLASSICAL COMPLEMENT PATHWAY. C4 is cleaved by the activated COMPLEMENT C1S into COMPLEMENT C4A and COMPLEMENT C4B.Complement C5: C5 plays a central role in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C5 is cleaved by C5 CONVERTASE into COMPLEMENT C5A and COMPLEMENT C5B. The smaller fragment C5a is an ANAPHYLATOXIN and mediator of inflammatory process. The major fragment C5b binds to the membrane initiating the spontaneous assembly of the late complement components, C5-C9, into the MEMBRANE ATTACK COMPLEX.Macular Degeneration: Degenerative changes in the RETINA usually of older adults which results in a loss of vision in the center of the visual field (the MACULA LUTEA) because of damage to the retina. It occurs in dry and wet forms.Complement C3-C5 Convertases: Serine proteases that cleave COMPLEMENT C3 into COMPLEMENT C3A and COMPLEMENT C3B, or cleave COMPLEMENT C5 into COMPLEMENT C5A and COMPLEMENT C5B. These include the different forms of C3/C5 convertases in the classical and the alternative pathways of COMPLEMENT ACTIVATION. Both cleavages take place at the C-terminal of an ARGININE residue.Complement C5a: The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.Meningitis, Bacterial: Bacterial infections of the leptomeninges and subarachnoid space, frequently involving the cerebral cortex, cranial nerves, cerebral blood vessels, spinal cord, and nerve roots.Papio: A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Cardiopulmonary Bypass: Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.Papio hamadryas: A species of baboon in the family CERCOPITHECIDAE, which has a well-studied trilevel social structure consisting of troops, bands, and clans.Transducers: Any device or element which converts an input signal into an output signal of a different form. Examples include the microphone, phonographic pickup, loudspeaker, barometer, photoelectric cell, automobile horn, doorbell, and underwater sound transducer. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.PhenylthioureaGene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Pragmatic Clinical Trials as Topic: Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Serine Endopeptidases: Any member of the group of ENDOPEPTIDASES containing at the active site a serine residue involved in catalysis.Dictionaries, ChemicalReagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Chickens: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.Abbreviations as Topic: Shortened forms of written words or phrases used for brevity.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Abbreviations: Works consisting of lists of shortened forms of written words or phrases used for brevity. Acronyms are included here.Population Density: Number of individuals in a population relative to space.Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Telefacsimile: A telecommunication system combining the transmission of a document scanned at a transmitter, its reconstruction at a receiving station, and its duplication there by a copier.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Feedback: A mechanism of communication within a system in that the input signal generates an output response which returns to influence the continued activity or productivity of that system.Outsourced Services: Organizational activities previously performed internally that are provided by external agents.Feedback, Psychological: A mechanism of information stimulus and response that may control subsequent behavior, cognition, perception, or performance. (From APA Thesaurus of Psychological Index Terms, 8th ed.)

Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D. (1/132)

The crystal structure of profactor D, determined at 2.1 A resolution with an Rfree and an R-factor of 25.1 and 20.4%, respectively, displays highly flexible or disordered conformation for five regions: N-22, 71-76, 143-152, 187-193 and 215-223. A comparison with the structure of its mature serine protease, complement factor D, revealed major conformational changes in the similar regions. Comparisons with the zymogen-active enzyme pairs of chymotrypsinogen, trypsinogen and prethrombin-2 showed a similar distribution of the flexible regions. However, profactor D is the most flexible of the four, and its mature enzyme displays inactive, self-inhibited active site conformation. Examination of the surface properties of the N-terminus-binding pocket indicates that Ile16 may play the initial positioning role for the N-terminus, and Leu17 probably also helps in inducing the required conformational changes. This process, perhaps shared by most chymotrypsinogen-like zymogens, is followed by a factor D-unique step, the re-orientation of an external Arg218 to an internal position for salt-bridging with Asp189, leading to the generation of the self-inhibited factor D.  (+info)

Calcium-independent haemolysis via the lectin pathway of complement activation in the guinea-pig and other species*. (2/132)

We previously reported that complement-dependent haemolysis of sheep erythrocytes (E) coated with mannan (M) and sensitized with human mannan-binding lectin (MBL) via the lectin pathway in man occurs in Mg-EGTA and requires alternative pathway amplification. Calcium was required for MBL binding to E-M, but once the E-M-MBL intermediate was formed, MBL was retained and haemolysis occurred in the absence of calcium. Comparable or greater lectin pathway haemolysis in the absence of calcium was observed upon incubation of E-M-MBL in guinea-pig, rat, dog and pig sera, and was further investigated in the guinea-pig, in which titres were much higher ( approximately 14-fold) than in man, and in contrast to humans, greater than classical pathway haemolytic activity. As in human serum, no lysis was observed in C4- or C2-deficient guinea-pig serum until purified C4 or C2, respectively, were restored. However, lectin pathway haemolytic activity in the guinea-pig did not require the alternative pathway. Removal (>98%) of factor D activity by three sequential passages through Sephadex G-75, resulting in serum which retained a normal classical pathway but no alternative pathway haemolytic activity, did not reduce the ability of guinea-pig serum to mediate haemolysis via the lectin pathway. Further, the C3-convertase formed via the lectin pathway (E-M-MBL-C4,2) lysed in C2-deficient guinea-pig but not human serum chelated with EDTA, a condition which precludes alternative pathway amplification. Thus, lectin pathway haemolysis occurs efficiently in guinea-pig serum, in the absence of calcium and without requirement for alternative pathway amplification. The guinea-pig provides a model for studying the assembly and haemolytic function of a lectin pathway which contrasts with the lectin pathway of man, and allows for comparisons that may help clarify the role of this pathway in complement biology.  (+info)

The Arthus reaction in rodents: species-specific requirement of complement. (3/132)

We induced reverse passive Arthus (RPA) reactions in the skin of rodents and found that the contribution of complement to immune complex-mediated inflammation is species specific. Complement was found to be necessary in rats and guinea pigs but not in C57BL/6J mice. In rats, within 4 h after initiation of an RPA reaction, serum alternative pathway hemolytic titers decreased significantly below basal levels, whereas classical pathway titers were unchanged. Thus the dermal reaction proceeds coincident with systemic activation of complement. The serine protease inhibitor BCX 1470, which blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat. These data support the proposal that complement-mediated processes are of major importance in the Arthus reaction in rats and guinea pigs, and suggest that BCX 1470 will be useful as an anti-inflammatory agent in diseases where complement activation is known to be detrimental.  (+info)

Mutational analysis of the primary substrate specificity pocket of complement factor B. Asp(226) is a major structural determinant for p(1)-Arg binding. (4/132)

Factor B is a serine protease, which despite its trypsin-like specificity has Asn instead of the typical Asp at the bottom of the S(1) pocket (position 189, chymotrypsinogen numbering). Asp residues are present at positions 187 and 226 and either one could conceivably provide the negative charge for binding the P(1)-Arg of the substrate. Determination of the crystal structure of the factor B serine protease domain has revealed that the side chain of Asp(226) is within the S(1) pocket, whereas Asp(187) is located outside the pocket. To investigate the possible role of these atypical structural features in substrate binding and catalysis, we constructed a panel of mutants of these residues. Replacement of Asp(187) caused moderate (50-60%) decrease in hemolytic activity, compared with wild type factor B, whereas replacement of Asn(189) resulted in more profound reductions (71-95%). Substitutions at these two positions did not significantly affect assembly of the alternative pathway C3 convertase. In contrast, elimination of the negative charge from Asp(226) completely abrogated hemolytic activity and also affected formation of the C3 convertase. Kinetic analyses of the hydrolysis of a P(1)-Arg containing thioester by selected mutants confirmed that residue Asp(226) is a primary structural determinant for P(1)-Arg binding and catalysis.  (+info)

C/EBPbeta, when expressed from the C/ebpalpha gene locus, can functionally replace C/EBPalpha in liver but not in adipose tissue. (5/132)

Knockout of C/EBPalpha causes a severe loss of liver function and, subsequently, neonatal lethality in mice. By using a gene replacement approach, we generated a new C/EBPalpha-null mouse strain in which C/EBPbeta, in addition to its own expression, substituted for C/EBPalpha expression in tissues. The homozygous mutant mice C/ebpalpha(beta/beta) are viable and fertile and show none of the overt liver abnormalities found in the previous C/EBPalpha-null mouse line. Levels of hepatic PEPCK mRNA are not different between C/ebpalpha(beta/beta) and wild-type mice. However, despite their normal growth rate, C/ebpalpha(beta/beta) mice have markedly reduced fat storage in their white adipose tissue (WAT). Expression of two adipocyte-specific factors, adipsin and leptin, is significantly reduced in the WAT of C/ebpalpha(beta/beta) mice. In addition, expression of the non-adipocyte-specific genes for transferrin and cysteine dioxygenase is reduced in WAT but not in liver. Our study demonstrates that when expressed from the C/ebpalpha gene locus, C/EBPbeta can act for C/EBPalpha to maintain liver functions during development. Moreover, our studies with the C/ebpalpha(beta/beta) mice provide new insights into the nonredundant functions of C/EBPalpha and C/EBPbeta on gene regulation in WAT.  (+info)

Induction of adipocyte-specific gene expression is correlated with mammary tumor regression by the retinoid X receptor-ligand LGD1069 (targretin). (6/132)

Targretin (LGD1069; a high-affinity ligand for the retinoid X receptors) is an efficacious chemotherapeutic and chemopreventive agent in the N-nitroso-N-methylurea-induced rat mammary carcinoma model. To evaluate the molecular action of LGD1069 in mammary carcinoma we have examined gene expression patterns in controls and nonresponding tumors compared with tumors undergoing regression (responding) by LGD1069. When compared with controls or nonresponding tumors, the expression of adipocyte-related genes such as adipocyte P2 (aP2), adipsin, peroxisome proliferator-activated receptor gamma (PPARgamma), and lipoprotein lipase was elevated in LGD1069-responding tumors. Further analysis showed that gene expression changes occurred rapidly, in as little as 6 h, after the first dose of LGD1069. Immunohistochemical analysis showed that aP2 protein was also highly expressed in responding tumors when compared with control or nonresponding tumors. More importantly, aP2 protein was localized in the tumor cells in addition to the adipocytes present in the tumors. Similar changes in gene expression and inhibition in growth were seen in tumor cells (cloned from N-nitroso-N-methylurea-induced carcinoma) exposed to LGD1069 in vitro. These data suggest that tumor regression by LGD1069 involves differentiation induction along the adipocyte lineage.  (+info)

A comparison of on-line hemodiafiltration and high-flux hemodialysis: a prospective clinical study. (7/132)

Some of the morbidity associated with chronic hemodialysis is thought to result from retention of large molecular weight solutes that are poorly removed by diffusion in conventional hemodialysis. Hemodiafiltration combines convective and diffusive solute removal in a single therapy. The hypothesis that hemodiafiltration provides better solute removal than high-flux hemodialysis was tested in a prospective, randomized clinical trial. Patients were randomized to either on-line postdilution hemodiafiltration or high-flux hemodialysis. The groups did not differ in body size, treatment time, blood flow rate, or net fluid removal. The filtration volume in hemodiafiltration was 21 +/-1 L. Therapy prescriptions were unchanged for a 12-mo study period. Removal of both small (urea and creatinine) and large (ss(2)-microglobulin and complement factor D) solutes was significantly greater for hemodiafiltration than for high-flux hemodialysis. The increased urea and creatinine removal did not result in lower pretreatment serum concentrations in the hemodiafiltration group. Pretreatment plasma beta(2)-microglobulin concentrations decreased with time (P< 0.001); however, the decrease was similar for both therapies (P = 0.317). Pretreatment plasma complement factor D concentrations also decreased with time (P<0.001), and the decrease was significantly greater with hemodiafiltration than with high-flux hemodialysis (P = 0.010). The conclusion is that on-line hemodiafiltration provides superior solute removal to high-flux hemodialysis over a wide molecular weight range. The improved removal may not result in lower pretreatment plasma concentrations, however, possibly because of limitations in mass transfer rates within the body.  (+info)

A family with complement factor D deficiency. (8/132)

A complement factor D deficiency was found in a young woman who had experienced a serious Neisseria meningitidis infection, in a deceased family member with a history of meningitis, and in three relatives without a history of serious infections. The patient and these three relatives showed a normal activity of the classical complement pathway, but a very low activity of the alternative complement pathway and a very low capacity to opsonize Escherichia coli and N. meningitidis (isolated from the patient) for phagocytosis by normal human neutrophils. The alternative pathway-dependent hemolytic activity and the opsonizing capacity of these sera were restored by addition of purified factor D. The family had a high degree of consanguinity, and several other family members exhibited decreased levels of factor D. The gene encoding factor D was found to contain a point mutation that changed the TCG codon for serine 42 into a TAG stop codon. This mutation was found in both alleles of the five completely factor D-deficient family members and in one allele of 21 other members of the same family who had decreased or low-normal factor D levels in their serum. The gene sequence of the signal peptide of human factor D was also identified. Our report is the first, to our knowledge, to document a Factor D gene mutation. The mode of inheritance of factor D deficiency is autosomal recessive, in accordance with the localization of the Factor D gene on chromosome 19. Increased susceptibility for infections in individuals with a partial factor D deficiency is unlikely.  (+info)

*Complement factor B

... is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component ... CFB complement factor B". Ambrus JL, Peters MG, Fauci AS, Brown EJ (March 1990). "The Ba fragment of complement factor B ... Christie DL, Gagnon J (January 1983). "Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major ... Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the ...

*Complement factor I

Factor I deficiency in turn leads to low levels of complement component 3 (C3), factor B, factor H and properdin. in plasma, ... complement factor I". Goldberger G, Bruns GA, Rits M, Edge MD, Kwiatkowski DJ (Jul 1987). "Human complement factor I: analysis ... Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. Complement ... Leitão MF, Vilela MM, Rutz R, Grumach AS, Condino-Neto A, Kirschfink M (Dec 1997). "Complement factor I deficiency in a family ...

*List of OMIM disorder codes

PSAP Complement component 4, partial deficiency of; 120790; C1NH Complement factor H deficiency; 609814; HF1 Complement factor ... GLA Factor V and factor VIII, combined deficiency of; 227300; MCFD2 Factor V deficiency; 227400; F5 Factor XI deficiency, ... F11 Factor XII deficiency; 234000; F12 Factor XIIIA deficiency; 613225; F13A1 Factor XIIIB deficiency; 613235; F13B Failure of ... LCAT Fletcher factor deficiency; 612423; KLKB1 Focal cortical dysplasia, Taylor balloon cell type; 607341; TSC1 Focal dermal ...

*Lampalizumab

It binds to complement factor D (CFD). Enrollment in Phase 3 clinical trials was initiated in 2014. Phase 3 trials are usually ... These two failures have called into question whether complement inhibition is a sound strategy for geographic atrophy. World ...

*Factor D

... (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, ... Factor D is involved in the alternative complement pathway of the complement system where it cleaves factor B. The protein ... Complement Factor D at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ... Volanakis JE, Narayana SV (1996). "Complement factor D, a novel serine protease". Protein Science. 5 (4): 553-64. doi:10.1002/ ...

*CFHR5

Like complement factor H, CFHR5 is able to bind to complement C3. A mutation in CHFR5 was found in patients with the disease ... "Entrez Gene: CFHR5 complement factor H-related 5". McRae JL, Duthy TG, Griggs KM, et al. (2005). "Human factor H-related ... 2006). "Variations in the complement regulatory genes factor H (CFH) and factor H related 5 (CFHR5) are associated with ... Complement factor H-related protein 5 is a protein that in humans is encoded by the CFHR5 gene. CFHR5 is structurally related ...

*CFHR2

Díaz-Guillén MA, Rodríguez de Córdoba S, Heine-Suñer D (1999). "A radiation hybrid map of complement factor H and factor H- ... Zipfel PF, Skerka C (1994). "Complement factor H and related proteins: an expanding family of complement-regulatory proteins ... "Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related ... Complement factor H-related protein 2 is a protein that in humans is encoded by the CFHR2 gene. GRCh38: Ensembl release 89: ...

*Genome-wide association study

These SNPs were located in the gene encoding complement factor H, which was an unexpected finding in the research of ARMD. The ... "Complement factor H variant increases the risk of age-related macular degeneration". Science. 308 (5720): 419-21. doi:10.1126/ ... "Complement factor H polymorphism in age-related macular degeneration". Science. 308 (5720): 385-9. doi:10.1126/science.1109557 ... In addition to the conceptual framework several additional factors enabled the GWA studies. One was the advent of biobanks, ...

*Synovial fluid

Complement factors are decreased in rheumatoid arthritis and lupus arthritis. Microscopic analysis of synovial fluid is ... Jay, GD; Britt, DE; Cha, CJ (March 2000). "Lubricin is a product of megakaryocyte stimulating factor gene expression by human ...

*Macular degeneration

The genes for the complement system proteins factor H (CFH), factor B (CFB) and factor 3 (C3) are strongly associated with a ... Despriet DD, Klaver CC, Witteman JC, Bergen AA, Kardys I, de Maat MP (2006). "Complement factor H polymorphism, complement ... on chromosome 10 at location 10q26 Complement Factor B/Complement Component 2 (CFB/CC2) on chromosome 6 at 6p21.3 Polymorphisms ... Absence of the complement factor H-related genes R3 and R1 protects against AMD. Two independent studies in 2007 showed a ...

*L-selectin

Malhotra R, Ward M, Sim RB, Bird MI (1999). "Identification of human complement Factor H as a ligand for L-selectin". Biochem. ... The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the ... The embryo secretes human chorionic gonadotropin (hCG), which downregulates anti-adhesion factor, MUC-1, located on the uterine ...

*Personalized medicine

"Complement Factor H Variant Increases the Risk of Age-Related Macular Degeneration". Science. 308 (5720): 419-21. doi:10.1126/ ... Some of the factors that should be considered are the level of efficacy of various genetic tests in the general population, ... "individual risk factors". Perhaps the most critical issue with the commercialization of personalised medicine is the protection ... there are a number of factors that must be considered. The detailed account of genetic information from the individual will ...

*CFHR4

Diaz-Guillen MA, Rodriguez de Cordoba S, Heine-Suner D (Jul 1999). "A radiation hybrid map of complement factor H and factor H- ... CFHR4 complement factor H-related 4". Hageman GS, Hancox LS, Taiber AJ, et al. (2007). "Extended Haplotypes in the Complement ... Complement factor H-related protein 4 is a protein that in humans is encoded by the CFHR4 gene. GRCh38: Ensembl release 89: ... 2000). "Functional properties of complement factor H-related proteins FHR-3 and FHR-4: binding to the C3d region of C3b and ...

*Atypical hemolytic uremic syndrome

... factor H, factor HR1 or HR3, membrane cofactor protein, factor I, factor B, complement C3, and thrombomodulin). This results in ... The complement system activation may be due to mutations in the complement regulatory proteins (factor H, factor I, or membrane ... of complement can result from production of anti-factor H autoantibodies or from genetic mutations in any of several complement ... "Platelet-associated complement factor H in healthy persons and patients with atypical HUS". Blood. 114 (20): 4538-4545. doi: ...

*CFHR3

"Entrez Gene: CFHR3 complement factor H-related 3". Zipfel PF, Skerka C (1994). "Complement factor H and related proteins: an ... Diaz-Guillen MA, Rodriguez de Cordoba S, Heine-Suner D (Jul 1999). "A radiation hybrid map of complement factor H and factor H- ... Complement factor H-related protein 3 is a protein that in humans is encoded by the CFHR3 gene. GRCh38: Ensembl release 89: ... 2000). "Complement factor H: sequence analysis of 221 kb of human genomic DNA containing the entire fH, fHR-1 and fHR-3 genes ...

*CFHR5 nephropathy

Complement factor H-related protein 5 (CFHR5) nephropathy (also known as Troodos nephropathy) is a form of inherited kidney ... 26 August 2010). "Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with ... "Recurrence of Complement Factor H-Related Protein 5 Nephropathy in a Renal Transplant". American Journal of Transplantation. 11 ... A kidney biopsy in patients with CFHR5 nephropathy classically shows deposition of complement C3 in the kidney, without any ...

*C3a (complement)

"The role of complement factor C3 in lipid metabolism". Molecular Immunology. 15th European Meeting on Complement in Human ... 12th European Meeting on Complement in Human Disease12th European Meeting on CHD12th European Meeting on Complement in Human ... that allows it to bind to a plasma protein called Factor B. This complex is then cleaved by Factor D, a serine protease, to ... Factor I, a serine protease activated by cofactors, can cleave and C3b and C4b, thus preventing convertase formation. C3 ...

*Factor I

... may refer to: Complement factor I, a protein of the complement system. Fibrinogen, a protein involved in blood ...

*Phagoptosis

Opsonins include Mfge8, Gas6, Protein S, antibodies and complement factors C1q and C3b. Phagoptosis has multiple functions ... Pathogenic cells such as bacteria can be opsonised by antibodies or complement factors, enabling their phagocytosis and ...

*CFHR1

"Entrez Gene: CFHR1 complement factor H-related 1". Zipfel PF, Skerka C (1994). "Complement factor H and related proteins: an ... Díaz-Guillén MA, Rodríguez de Córdoba S, Heine-Suñer D (1999). "A radiation hybrid map of complement factor H and factor H- ... related to complement factor H are different glycosylation forms of a single protein with no factor H-like complement ... Complement factor H-related protein 1 is a protein that in humans is encoded by the CFHR1 gene. GRCh38: Ensembl release 89: ...

*C4A

Complement C4-A is a protein that in humans is encoded by the C4A gene. This gene encodes the acidic form of complement factor ... "A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B". ... Hessing M, van 't Veer C, Hackeng TM, Bouma BN, Iwanaga S (Oct 1990). "Importance of the alpha 3-fragment of complement C4 for ... Hortin G, Sims H, Strauss AW (Feb 1986). "Identification of the site of sulfation of the fourth component of human complement ...

*Complement component 4B

This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as ... Aoki H, Takizawa F, Tsuji S, Nagasawa S (Jul 2000). "Elongation factor-1alpha as a homologous complement activator of Jurkat ... Complement component 4B (Chido blood group) is a protein that in humans is encoded by the C4B gene. ... Pan Q, Ebanks RO, Isenman DE (Sep 2000). "Two clusters of acidic amino acids near the NH2 terminus of complement component C4 ...

*Acute-phase protein

Some act to destroy or inhibit growth of microbes, e.g., C-reactive protein, mannose-binding protein, complement factors, ... Alpha 2-macroglobulin and coagulation factors affect coagulation, mainly stimulating it. This pro-coagulant effect may limit ...

*Properdin deficiency

... is a rare X-linked disease in which properdin, an important complement factor, is deficient. Affected ...

*Angioedema

In this analysis, it is usually a reduced complement factor C4, rather than the C1-INH deficiency itself, that is detected. The ... 2006). "Increased activity of coagulation factor XII (Hageman factor) causes hereditary angioedema type III". Am. J. Hum. Genet ... especially depletion of complement factors 2 and 4, may indicate deficiency of C1-inhibitor. HAE type III is a diagnosis of ... which encodes the coagulation protein factor XII. All forms of HAE lead to abnormal activation of the complement system, and ...

*Newbold College

One factor for this choice was its proximity to Oxford and London. The existing campus is also within close proximity to ... to complement the terraces and gardens which Hill created over 1910-13. These are listed Grade II* in the National Register of ...
1HFD: Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity.
Barraquer-Simons syndrome (or acquired partial lipodystrophy, cephalothoracic lipodystrophy, and progressive lipodystrophy)) is a rare form of lipodystrophy, which usually first affects the head, and then spreads to the thorax. It is named for Luis Barraquer Roviralta (1855-1928), a Spanish physician, and Arthur Simons (1879-1942), a German physician. Some evidence links it to LMNB2. The etiology of this condition has not been fully elucidated. Lipodystrophy is often associated with glomerulonephritis, low C3 serum complement levels, and the presence of a C3 nephritic factor. C3 nephritic factor is a serum immunoglobulin G that interacts with the C3bBb alternative pathway convertase to activate C3. C3 nephritic factor induces the lysis of adipocytes that secrete adipsin, a product identical to complement factor D. The distribution of the lipoatrophy is postulated to be dictated by the variable amounts of adipsin secreted by the adipocytes at different locations. Human PTRF mutations may cause ...
Eculizumab, a humanized anti-complement C5 monoclonal antibody for treatment of paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome, blocks the terminal complement pathway required for serum bactericidal activity (SBA). Because treated patients are at ,1000-fold increased risk of meningococcal disease, vaccination is recommended, but whether vaccination can protect by opsonophagocytic activity in the absence of SBA is not known. Meningococci were added to anticoagulated blood from 12 healthy adults vaccinated with meningococcal serogroup B and serogroup A,C,W,Y vaccines. Bacterial survival was measured after 3 hours incubation in the presence of eculizumab or, a control complement factor D inhibitor, ACH-4471, that blocks the alternative complement pathway (AP) and is in phase 2 development for treatment of PNH. In the absence of inhibitors, CFU/ml in blood from all 12 immunized subjects decreased from ~4000 at time 0 to sterile cultures at 3 hours. In the presence ...
Mouse Factor D ELISA Kit is a sensitive (0.03 ng/ml) immunoassay suitable for the quantification of Factor D in Cell culture supernatant, Urine, Serum, Plasma samples.
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Factor D兔多克隆抗体(ab111204)可与人样本反应并经WB实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Looking for online definition of adipsin in the Medical Dictionary? adipsin explanation free. What is adipsin? Meaning of adipsin medical term. What does adipsin mean?
This press release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that are subject to risks, uncertainties and other important factors that could cause actual results to differ materially from those indicated by such forward-looking statements. Achillion may use words such as "expect," "anticipate," "project," "target," "intend," "plan," "aim," "believe," "seek," "estimate," "can," "could," "focus," "will," "look forward," "continue," "goal," "strategy," "objective," "may," "potential," and similar expressions to identify such forward-looking statements. These forward-looking statements include statements about: the potential benefits of factor D inhibition as a treatment for complement-mediated diseases, including danicopan (ACH-4471) for PNH; the potential benefits of, and indications for, Achillions compounds that inhibit factor D, including danicopan and ACH-5228; Achillions belief that its portfolio of compounds could expand ...
From NCBI Gene:. This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]. From UniProt: ...
Anti-neutrophil cytoplasmic antibodies are linked to an increased prevalence of interstitial lung disease and pulmonary embolism in systemic sclerosis, according to data published in Arthritis Research & Therapy.. "The clinical significance of ANCA in [systemic sclerosis (SSc)] patients who do not manifest [ANCA-associated vasculitis] is controversial. An association between ANCA in SSc and [interstitial lung disease] has been suggested," Mandana Nikpour, PhD, MBBS, FRACP, FRCPA, of the University of Melbourne, Australia, and colleagues wrote. "However, this has not been consistently reported in all case series. It has also been suggested that ANCA in SSc patients may indicate an inflammatory component to the illness and that ANCA should be treated as a red flag, prompting a thorough investigation and follow-up." ...
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Properdin factor d definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
Press Release issued Jul 24, 2014: Reportstack, provider of premium market research reports announces the addition of Vascular Endothelial Growth Factor D (VEGF-D) Inhibitors -Pipeline Insights, 2014 market report to its offering DelveInsights,Vascular Endothelial Growth Factor D (VEGF-D) Inhibitors-Pipeline Insights, 2014, report provides comprehensive insights about pipeline drugs across this mechanism of action (MOA).
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Looking for online definition of Complement factor b in the Medical Dictionary? Complement factor b explanation free. What is Complement factor b? Meaning of Complement factor b medical term. What does Complement factor b mean?
BCX 1470 is a serine protease inhibitor with the IC50 of 96 nM for factor D and 1.6 nM for C1s. Serine proteases are enzymes that cleave peptide bonds in proteins which are found ubiquitously in both eukaryotes and prokaryotes and serine serves as the nucleophilic amino acid at the active site. According to structure, serine proteases are divided into trypsin-like (chymotrypsin-like) family and subtilisin-like family. It is reported that serine proteases play an important role in various physiological functions, including digestion, immune response, blood coagulation and reproduction. BCX 1470 is a potent serine protease inhibitor and functions on the complement enzymes CIs and factor D sites. By determining the ability of enzyme to hydrolyze appropriate synthetic substrates, the result showed that BCX 1470 inhibited the factor D and C1s esterolytic activity which were important in the function of serine protease. In induced dermal RPA reaction rat model, administration of BCX 1470 markedly ...
Jenny, Lorenz and Dobó, József and Gál, Péter and Pál, Gábor and Lam, Wilbur A. and Schroeder, Verena (2018) MASP-1 of the complement system enhances clot formation in a microvascular whole blood flow model. PLOS ONE, 13 (1). pp. 1-14. ISSN 1932-6203 Oroszlán, Gábor and Dani, Ráhel and Szilágyi, András and Závodszky, Péter and Thiel, Steffen and Gál, Péter and Dobó, József (2017) Extensive Basal Level Activation of Complement Mannose-Binding Lectin-Associated Serine Protease-3: Kinetic Modeling of Lectin Pathway Activation Provides Possible Mechanism. FRONTIERS IN IMMUNOLOGY, 8. pp. 1-14. ISSN 1664-3224 Tóbiás, Zoltán and Pálinkó, Dóra and Sztanó, Balázs and Csanády, Miklós and Gál, Péter and Rovó, László (2017) A laryngomalacia endoszkópos ultrapulzációs-lézeres (ultra dream pulse) sebészete. A módszer hazai bevezetése során szerzett tapasztalataink , Endoscopic ultra dream pulse laser surgery of laryngomalacia. Our experiences gained during the ...
The IUPHAR/BPS Guide to Pharmacology. complement factor B - S1: Chymotrypsin. Detailed annotation on the structure, function, physiology, pharmacology and clinical relevance of drug targets.
There are two concepts behind the alternative pathway of complement: what occurs when a non-self cell is absent; and what occurs when a non-self cell is present. When a non-self cell is absent (meaning the tissue is healthy) then there is fluid-phase activation. Fluid-phase activation occurs continuously, spontaneously and very slowly. In fluid-phase activation, C3 spontaneously activates via hydrolysis to form C3H2O -- since it is unstable, C3H2O usually reverts to C3. However, if C3H2O encounters Factor B, then the two molecules bind to form a more stable C3H2OB molecule. Factor D then cleaves C3H2OB molecule to yield the enzyme C3H2OBb (aka fluid-phase C3 convertase). C3H2OBb has an active site on Bb; to culminate fluid-phase activation, this active site cleaves C3 into C3a and C3b. Fluid-phase activation is depicted in the figure to the left.. When a non-self cell is present, then a much faster process occurs. C3b binds to the surface of the non-self cell, then Factor B binds to the C3b. ...
Mouse polyclonal antibody raised against a full-length human ANAPC4 protein. ANAPC4 (NP_037499, 1 a.a. ~ 808 a.a) full-length human protein. (H00029945-B01) - Products - Abnova
Complete information for ANAPC16 gene (Protein Coding), Anaphase Promoting Complex Subunit 16, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
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The alternative pathway is continuously activated at a low level, analogous to a car engine at idle, as a result of spontaneous C3 hydrolysis due to the breakdown of the internal thioester bond (C3 is mildly unstable in aqueous environment). The alternative pathway does not rely on pathogen-binding antibodies like the other pathways.[2] C3b that is generated from C3 by a C3 convertase enzyme complex in the fluid phase is rapidly inactivated by factor H and factor I, as is the C3b-like C3 that is the product of spontaneous cleavage of the internal thioester. In contrast, when the internal thioester of C3 reacts with a hydroxyl or amino group of a molecule on the surface of a cell or pathogen, the C3b that is now covalently bound to the surface is protected from factor H-mediated inactivation. The surface-bound C3b may now bind factor B to form C3bB. This complex in the presence of factor D will be cleaved into Ba and Bb. Bb will remain associated with C3b to form C3bBb, which is the alternative ...
FIGF - FIGF (GFP-tagged) - Human c-fos induced growth factor (vascular endothelial growth factor D) (FIGF) available for purchase from OriGene - Your Gene Company.
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
With the exception of adiponectin and adipsin, all assays may be ordered as either customized Express assays or as singleplex sets (vial of beads coupled to capture antibodies and vial of detection antibodies). Requires standard and Bio-Plex Pro reagent kit to perform an assay. To learn more about Express assays, go to www.bio-rad.com/bio-plex/assaybuilder ...
Expression of ANAPC4 (APC4) in soft tissue 1 tissue. Antibody staining with HPA038395, HPA038396 and CAB032519 in immunohistochemistry.
Factor B antibody, Internal (complement factor B) for FACS, IHC-P, WB. Anti-Factor B pAb (GTX80605) is tested in Human samples. 100% Ab-Assurance.
The optimal reaction conditions for hemolytic assay of alternative complement pathway activity in mouse serum were investigated. A microtiter system was used, in which a number of 7.5×106 rabbit erythrocytes per test well appeared to be optimal. Rabbit erythrocytes were superior as target cells over erythtocytes from a number of ... read more other animal species. The optimal conditions were as follows: an incubation temperature of 39°C, an ionic strength of about 200 mM, and a magnesium concentration of 2.5 mM. Incubation during 60 min was not sufficient for an end-point titration. Addition of 1 mg of zymosan A per test well, however, enhanced and accelerated the hemolytic activity of mouse serum via the alternative pathway resulting in a maximum value after 45 min. This, most probably, proceeded by a mechanism involving the formation of a zymosan-C5-convertase and bystander lysis of the target cells. In contrast to the normal alternative pathway assay the zymosan-potentiated test did, most ...
This Pre-made optional inducible lentiviral particles expresses human target, PDGFD (platelet derived growth factor D, transcript variant 1) (alternative name: IEGF; MSTP036; SCDGF-B; SCDGFB). The sub-cloned codon sequence is identical (100% match) to CDS region in NCBI ID: NM_025208.4.. The full sequence-verified target is natively expressed under an optional inducible suCMV promoter. This lentivirus can be used for regular constitutive high expression (without any induction) or used for inducible expression with tetracycline or Dox induction when the tetracycline repressor protein (TetR) is present. A Blasticidin-RFP fusion dual marker under the RSV promoter allows fluorescence sorting or blasticidin resistance selection of transduced cells. The RFP signal additionally provides convenient, real-time monitoring of the particles performance.. Each Lentivirus is validated on lot-by-lot basis, and target expression is guaranteed. See Product Manual for details (.pdf). Amount: 200ul, at 1 x 107 ...
Background C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind...
Complete information for ANAPC1 gene (Protein Coding), Anaphase Promoting Complex Subunit 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Expression of ANAPC4 (APC4) in lymph node tissue. Antibody staining with HPA038395, HPA038396 and CAB032519 in immunohistochemistry.
The complement system provides a fundamental component of the body's immune response to invading microorganisms. This chapter highlights the various roles of the complement system in the orchestration of the immune response towards microbial infections, gives examples of microbial strategies to evade complement-mediated clearance, and discusses how acquired and inherited complement deficiencies may predispose an organism to infectious disease. Complement is activated by three pathways: the classical pathway, the alternative pathway, and the lectin pathway. The lectin pathway is activated by carbohydrate recognition molecules that bind to polysaccharide on the surface of a pathogen. Factor B, factor D, and properdin (factor P) are specific components of the alternative pathway of complement activation. The complement activation is tightly regulated by membrane-bound and fluid-phase regulatory components to avoid runaway activation of the enzymatic cascade that could lead to excess host tissue damage
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Perform reliable qPCR with Bio-Rads pre-validated ANAPC13 primer pair, for the Human genome. Designed for SYBR Green-based detection.
Complement pathways function to identify and remove pathogens and infected cells. There are three complement pathways: the classical, lectin and alternative pathway (AP). While all pathways are activated following pathogen stimuli, the AP is constitutively active and tightly controlled by activators (e.g., Factor B, Factor D) and negative regulators (e.g., Factor H). Complement activity can be measured by well-established methods that are often used in a diagnostic setting to determine the CH50 (50% complement hemolytic activity) or AP50, specifically to measure AP activity. The protocol here has adapted the traditional AP50 method designed to measure AP activity in human sera, to measure the positive or negative AP regulatory activity within a given test sample. The assay relies on the ability of AP components in human serum to lyse rabbit erythrocytes under in vitro conditions specific for the AP with subsequent release of hemoglobin that is quantitated by measurement of optical density. Our method
Shares are down 48% in mid-morning trading.. Bluebird battered. Cambridge, MA-based bluebird bio $BLUE, meanwhile, didnt impress anyone with its latest update on Lentiglobin. Its shares are down 16% on continued mixed results for its gene therapy for beta-thalassemia.. There is a super responder in the mix and the biotech continues to tout its successes, but a number of patients arent responding as well, and that has analysts worried that bluebird will have to do much better with a follow-on drug. Not what investors were hoping to see, but disappointment has become something of a habit for bluebird over the last year.. Achillion crashes. Then theres Achillion Pharmaceuticals $ACHN oral factor D inhibitor ACH-4471. That drug is being investigated for conditions that include paroxysmal nocturnal hemoglobinuria (PNH). And it has a safety issue as well, which crushed its stock, now down 32%.. ...
CNS depression and seizures (focal and generalized) have occurred following overdose. A. Dizziness and dystonic movement disorders have also been reported. With therapeutic use - aseptic meningitis has been associated with naproxen. Naproxen is pregnancy category B. ,br,   1. Risk Factor D if used in 3rd trimester or near delivery. ,br,Because of known effects of the fetus (closure of ductus arteriosus), it should be avoided during late pregnancy. ,br,Naproxen has been found in the milk of lactating women; however, The American Academy of Pediatrics considers naproxen to be compatible with breast feeding (Briggs et al, 1998 ...

Anti-CFI / Complement Factor I Antibody (Internal) - Rabbit Anti Human Polyclonal Antibody WB, IHC-P - Buy Now! |AbgentAnti-CFI / Complement Factor I Antibody (Internal) - Rabbit Anti Human Polyclonal Antibody WB, IHC-P - Buy Now! |Abgent

Complement Factor I Antibody (Internal), Rabbit Anti Human Polyclonal Antibody validated in WB, IHC-P (ALS17749), Abgent ... Complement component factor i, Factor I, FI, KAF, I factor, I factor (complement), C3b-INA, Complement factor I, Light chain of ... Anti-CFI / Complement Factor I Antibody (Internal) is for research use only and not for use in diagnostic or therapeutic ... home , Products , Primary Antibodies , Antibody Collections , GPCR Antibodies , Anti-CFI / Complement Factor I Antibody ( ...
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Human complement factor HHuman complement factor H

Schulz, T. F.; Schwaeble, W.; Stanley, K. K.; Weiss, Elisabeth H.; Dierich, Manfred P. (1986): Human complement factor H. ... kDa fragment of human complement control protein factor H using polyclonal and monoclonal antibodies to screen a human liver ...
more infohttps://epub.ub.uni-muenchen.de/3093/index.html

Complement factor B - WikipediaComplement factor B - Wikipedia

Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component ... CFB complement factor B". Ambrus JL, Peters MG, Fauci AS, Brown EJ (March 1990). "The Ba fragment of complement factor B ... Christie DL, Gagnon J (January 1983). "Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major ... Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the ...
more infohttps://en.wikipedia.org/wiki/Complement_factor_B

Complement factor I - WikipediaComplement factor I - Wikipedia

Factor I deficiency in turn leads to low levels of complement component 3 (C3), factor B, factor H and properdin. in plasma, ... complement factor I". Goldberger G, Bruns GA, Rits M, Edge MD, Kwiatkowski DJ (Jul 1987). "Human complement factor I: analysis ... Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. Complement ... Leitão MF, Vilela MM, Rutz R, Grumach AS, Condino-Neto A, Kirschfink M (Dec 1997). "Complement factor I deficiency in a family ...
more infohttps://en.wikipedia.org/wiki/Complement_factor_I

Activated Complement Factors as Disease Markers for SepsisActivated Complement Factors as Disease Markers for Sepsis

... Jean Charchaflieh,1 Julie Rushbrook,2 Samrat Worah,2 and Ming Zhang ...
more infohttps://www.hindawi.com/journals/dm/2015/382463/sup/

Complement Factor H Antibodies: Novus BiologicalsComplement Factor H Antibodies: Novus Biologicals

Browse our Complement Factor H Antibodies all backed by our Guarantee+. ... Complement Factor H Antibodies available through Novus Biologicals. ... anti-H factor 1 (complement) antibody, anti-H factor 1 antibody, anti-H factor 2 (complement) antibody, anti-HF antibody, anti- ... Complement Factor H Antibodies. We offer Complement Factor H Antibodies for use in common research applications: ELISA, Flow ...
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Complement Factor H Antibodies: Novus BiologicalsComplement Factor H Antibodies: Novus Biologicals

Browse our Complement Factor H Antibodies all backed by our Guarantee+. ... Complement Factor H Antibodies available through Novus Biologicals. ... anti-H factor 1 (complement) antibody, anti-H factor 1 antibody, anti-H factor 2 (complement) antibody, anti-HF antibody, anti- ... Complement Factor H Antibodies. We offer Complement Factor H Antibodies for use in common research applications: ELISA, Flow ...
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Recombinant Human Complement factor B protein (denatured) (ab174401)Recombinant Human Complement factor B protein (denatured) (ab174401)

Buy our Recombinant Human Complement factor B protein (denatured). Ab174401 is a protein fragment produced in Escherichia coli ... Recombinant Human Complement factor B protein (denatured). See all Complement factor B proteins and peptides. ... Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb ... a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in ...
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RCSB PDB - Protein Feature View 









 - Complement factor H - P08603 (CFAH HUMAN)RCSB PDB - Protein Feature View - Complement factor H - P08603 (CFAH HUMAN)

Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the ... C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway. UniProt ...
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CFHR5 complement factor H related 5 [Homo sapiens (human)] - Gene - NCBICFHR5 complement factor H related 5 [Homo sapiens (human)] - Gene - NCBI

CFHR5 complement factor H related 5 [Homo sapiens] CFHR5 complement factor H related 5 [Homo sapiens]. Gene ID:81494 ... complement factor H-related protein 5. Names. factor H-related protein 5. ... Studies indicate that complement factor H-related proteins (FHR1-5) may enhance complement activation, with important ... Title: Complement factor H-related hybrid protein deregulates complement in dense deposit disease. ...
more infohttps://www.ncbi.nlm.nih.gov/gene?LinkName=pubmed_gene_citedinomim&from_uid=20513133

Complement Factor H Polymorphism in Age-Related Macular Degeneration | ScienceComplement Factor H Polymorphism in Age-Related Macular Degeneration | Science

Complement Factor H Polymorphism in Age-Related Macular Degeneration. By Robert J. Klein, Caroline Zeiss, Emily Y. Chew, Jen- ... Complement Factor H Polymorphism in Age-Related Macular Degeneration. By Robert J. Klein, Caroline Zeiss, Emily Y. Chew, Jen- ... Complement Factor H Polymorphism in Age-Related Macular Degeneration Message Subject. (Your Name) has forwarded a page to you ... Among 116,204 single-nucleotide polymorphisms genotyped, an intronic and common variant in the complement factor H gene (CFH) ...
more infohttps://science.sciencemag.org/content/308/5720/385

Complement Factor H Polymorphism in Age-Related Macular Degeneration | ScienceComplement Factor H Polymorphism in Age-Related Macular Degeneration | Science

Both age and smoking, two important risk factors for AMD, influence plasma levels of complement factor H (28). CFH sequences ... Complement Factor H Polymorphism in Age-Related Macular Degeneration. By Robert J. Klein, Caroline Zeiss, Emily Y. Chew, Jen- ... Complement Factor H Polymorphism in Age-Related Macular Degeneration. By Robert J. Klein, Caroline Zeiss, Emily Y. Chew, Jen- ... Complement Factor H Polymorphism in Age-Related Macular Degeneration Message Subject. (Your Name) has forwarded a page to you ...
more infohttps://science.sciencemag.org/content/308/5720/385?ijkey=7fdcd97e78f58621cda6bab98d0efa7b6e00ef9c&keytype2=tf_ipsecsha

CFD - Complement factor D precursor - Homo sapiens (Human) - CFD gene & proteinCFD - Complement factor D precursor - Homo sapiens (Human) - CFD gene & protein

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 ... "Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D ... "Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D ... "Deficient alternative complement pathway activation due to factor D deficiency by 2 novel mutations in the complement factor D ...
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CFH / Complement Factor H - LSBioCFH / Complement Factor H - LSBio

CFH / Complement Factor H. complement factor H. CFH / Complement Factor H is a member of the Regulator of Complement Activation ... Factor H-like 1, HF, HF2, H factor 1, H factor 2 (complement), HUS, HF1, Beta-1H, CFHL3, Complement factor H, H factor 1 ( ... complement factor H. Synonyms:. CFH, Adrenomedullin binding protein, AHUS1, AMBP1, ARMS1, ARMD4, Beta-1-H-globulin, Factor H, ... IHC-plus™ CFH / Complement Factor H Antibody (clone OX-24) LS-B2889 ...
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Complement Factor B | Profiles RNSComplement Factor B | Profiles RNS

"Complement Factor B" by people in this website by year, and whether "Complement Factor B" was a major or minor topic of these ... The association between complement component 2/complement factor B polymorphisms and age-related macular degeneration: a HuGE ... is generated when factor B is cleaved by COMPLEMENT FACTOR D into Ba and Bb. ... "Complement Factor B" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ...
more infohttps://profiles.umassmed.edu/display/121656

Role of Complement Factors on NCIPHRole of Complement Factors on NCIPH

ADAMTS13 and Von Willebrand factor in pathogenesis of non cirrhotic intrahepatic portal hypertension (NCIPH) in... ... and the activation of these complement factors are regulated by the complement factor H (CFH). Hence, any problem in any of ... www.ukessays.com/essays/biology/role-complement-factors-nciph-2472.php?vref=1 ,title=Role of Complement Factors on NCIPH , ... Role of complement factors, ADAMTS13 and Von Willebrand factor in pathogenesis of non cirrhotic intrahepatic portal ...
more infohttps://www.ukessays.com/essays/biology/role-complement-factors-nciph-2472.php

Complement factor H gene associations with end-stage kidney disease in African Americans.  - PubMed - NCBIComplement factor H gene associations with end-stage kidney disease in African Americans. - PubMed - NCBI

Complement factor H gene associations with end-stage kidney disease in African Americans.. Bonomo JA1, Palmer ND2, Hicks PJ3, ... Mutations in the complement factor H gene (CFH) region associate with renal-limited mesangial proliferative forms of ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/24586071?dopt=Abstract

Complement Factor B ELISA & Assay KitsComplement Factor B ELISA & Assay Kits

Complement Factor B ELISA Kits vergleichen und bestellen. ... Complement Factor B ELISA Kits für viele Reaktivitäten. Huhn, ... complement component factor B , complement factor B , complement component 2 , complement factor Bf-1 , ATP synthase subunit s ... Complement Factor B (CFB) Antigen-Profil Beschreibung des Gens This gene encodes complement factor B, a component of the ... Am meisten referenzierte Complement Factor B ELISA Kits. Show all Complement Factor B (CFB) ELISA Kits with Pubmed References. ...
more infohttps://www.antikoerper-online.de/komplementsystem-pathway-11/complement-factor-b-elisa-kit-2942/

anti-Complement Factor H Antikörper (PerCP) | Produkt Nr. ABIN4264777anti-Complement Factor H Antikörper (PerCP) | Produkt Nr. ABIN4264777

Jetzt diesen anti-Complement Factor H Antikörper bestellen. , Produkt ABIN4264777 ... Maus Monoklonal Complement Factor H Antikörper für ELISA, WB. ... anti-Complement Factor D Antikörper * anti-Complement Factor B ... Target Details Complement Factor H Handhabung Anwendungsinformationen zurück nach oben Target Details Complement Factor H ... anti-Complement Factor H Antikörper (CFH) (PerCP) Complement Factor H Antikörper (CFH) (PerCP). Details for Product anti-CFH ...
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RCSB PDB 









- 1HFD: HUMAN COMPLEMENT FACTOR D IN A P21 CRYSTAL FORM Methods Report PageRCSB PDB - 1HFD: HUMAN COMPLEMENT FACTOR D IN A P21 CRYSTAL FORM Methods Report Page

Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory ... R-Factor (R-Work). R-Factor (R-Free). R-Factor (R-Free Error). Percent Reflections (Observed). ... R-Factor (All). R-Factor (Observed). R-Work. R-Free. R-Free Selection Details. ...
more infohttp://www.rcsb.org/pdb/explore/materialsAndMethods.do?structureId=1HFD

Complement factor H (CFH) antibody | acris-antibodies.comComplement factor H (CFH) antibody | acris-antibodies.com

The complement Factor H protein is secreted into the bloodstream and acts in the regulation of complement activation. Mutations ... Rabbit polyclonal antibody to Complement factor H (complement factor H). Rabbit. IgG. Aff - Purified. Hu. P, WB. 0.1 ml / € ... Background of Complement factor H (CFH) antibody. The complement Factor H protein is secreted into the bloodstream and acts in ... Complement factor H (CFH) antibody. Not available. Sheep. IgG. Ig Fraction. Can, Eq, Fe, GP, Hu, Ms, Rt. C, ID, WB. 1 ml / € ...
more infohttps://www.acris-antibodies.com/target/complement-factor-h-cfh-antibody.htm

Targeting Complement Factor D Reduces Progression of AMD-Related Geographic Atrophy - American Academy of OphthalmologyTargeting Complement Factor D Reduces Progression of AMD-Related Geographic Atrophy - American Academy of Ophthalmology

conducted a clinical trial of lampalizumab, an inhibitor of complement factor D, and noted a potential therapeutic effect on ... Targeting Complement Factor D Reduces Progression of AMD-Related Geographic Atrophy Written By: Lynda Seminara. Selected By: ... conducted a clinical trial of lampalizumab, an inhibitor of complement factor D, and noted a potential therapeutic effect on GA ... In a subgroup of complement factor I (CFI) risk-allele carriers (representing 57% of all patients analyzed), monthly active ...
more infohttps://www.aao.org/eyenet/article/targeting-complement-factor-d

Transcriptome sequencing implicate alterations of complement factor levels in schizophrenia.Transcriptome sequencing implicate alterations of complement factor levels in schizophrenia.

... Carlström Lindholm, Eva Uppsala ... In this study we could show that the immune system and more specifically the complement system was dysregulated in a large ...
more infohttp://uu.diva-portal.org/smash/record.jsf?pid=diva2:922690

Complement Factor H is expressed in adipose tissue in association with insulin resistance | DiabetesComplement Factor H is expressed in adipose tissue in association with insulin resistance | Diabetes

Objective: Activation of the alternative pathway of the complement system, in which factor H (fH; CFH) is a key regulatory ... To study the associations between circulating and adipose tissue gene expressions of CFH and complement factor B (fB; CFB) with ... Complement Factor H is expressed in adipose tissue in association with insulin resistance ... Complement Factor H is expressed in adipose tissue in association with insulin resistance ...
more infohttp://diabetes.diabetesjournals.org/content/early/2009/10/14/db09-0700

Mouse Complement Factor D/Adipsin DuoSet ELISA DY5430-05: R&D SystemsMouse Complement Factor D/Adipsin DuoSet ELISA DY5430-05: R&D Systems

View Factor D/Adipsin DuoSet ELISA Cat# DY5430-05 details. ... Build a mouse Factor D/Adipsin ELISA with DuoSet®; 375-6,000 pg ... complement factor D (adipsin); complement factor D preproprotein; Complement Factor D; D component of complement (adipsin); DF ... Background: Complement Factor D/Adipsin. Complement Factor D, also known as adipsin, is a serine protease that catalyzes the ... Home / Complement Factor D/Adipsin / Mouse Complement Factor D/Adipsin DuoSet ELISA ...
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  • VEGF regulates local inhibitory complement proteins in the eye and kidney. (lsbio.com)
  • In analogy to the newly described neuroimmune regulatory proteins also known as "don't eat me" signals (CD200, CD47, CD22, fractalkine, semaphorins), we herein identify the key role of complement regulator factor H (fH) in controlling neuroinflammation initiated in an acute mouse model of Ab-dependent experimental autoimmune encephalomyelitis. (jimmunol.org)
  • Factor H (H) is a crucial fluid phase regulator of the AP, as it is an essential cofactor for factor I (C3b inactivator) in the proteolytic inactivation of C3b and C3(H 2 O) ( 6 , 7 ). (jimmunol.org)
  • The complement system is a fundamental element of the innate immune system as well as the adaptive immune responses. (ukessays.com)
  • Whereas much attention has been focused on the properties and activities of the TLRs in this process ( 13 ), many other innate immune molecules expressed by glia and neurons have been described (e.g., complement, lectins, scavenger receptors) ( 14 ). (jimmunol.org)
  • Abnormalities in factor H have been associated with renal disease (PMID: 18190458). (ptglab.com)
  • This site fitted considerably well with a putative binding site in the molecular model of domain 3 of factor H containing a reciprocal ring of charged amino acids around a hydrophobic area. (jimmunol.org)
  • The alternative complement pathway (AP) 3 acts as a first-line defense mechanism against a wide range of targets. (jimmunol.org)
  • Atypical hemolytic uremic syndrome and genetic aberrations in the complement factor H-related 5 gene. (nih.gov)
  • In man, a deficiency of factor H has been found in association with glomerulonephritis and/or the hemolytic uremic syndrome ( 18 , 19 , 20 ). (jimmunol.org)