Comparative Effectiveness Research
United States Agency for Healthcare Research and Quality
American Recovery and Reinvestment Act
Patient Protection and Affordable Care Act
Observational Study as Topic
Electronic Health Records
Translational Medical Research
Health Care Reform
Outcome Assessment (Health Care)
Randomized Controlled Trials as Topic
Outcome and Process Assessment (Health Care)
Diffusion of Innovation
Delivery of Health Care
Data Interpretation, Statistical
Clinical Trials as Topic
The policies and politics of creating a comparative clinical effectiveness research center. (1/390)(+info)
'Marginal medicine': targeting comparative effectiveness research to reduce waste. (2/390)(+info)
Developing a policy for second-generation antipsychotic drugs. (3/390)(+info)
Comparative effectiveness research for antipsychotic medications: how much is enough? (4/390)(+info)
Does telemonitoring of patients--the eICU--improve intensive care? (5/390)(+info)
Measurement of and reward for efficiency In California's pay-for-performance program. (6/390)(+info)
Is it time to reexamine the patent system's role in spending growth? (7/390)(+info)
Gemcitabine for the treatment of metastatic breast cancer. (8/390)(+info)
Neoplasm refers to an abnormal growth of cells that can be benign (non-cancerous) or malignant (cancerous). Neoplasms can occur in any part of the body and can affect various organs and tissues. The term "neoplasm" is often used interchangeably with "tumor," but while all tumors are neoplasms, not all neoplasms are tumors.
Types of Neoplasms
There are many different types of neoplasms, including:
1. Carcinomas: These are malignant tumors that arise in the epithelial cells lining organs and glands. Examples include breast cancer, lung cancer, and colon cancer.
2. Sarcomas: These are malignant tumors that arise in connective tissue, such as bone, cartilage, and fat. Examples include osteosarcoma (bone cancer) and soft tissue sarcoma.
3. Lymphomas: These are cancers of the immune system, specifically affecting the lymph nodes and other lymphoid tissues. Examples include Hodgkin lymphoma and non-Hodgkin lymphoma.
4. Leukemias: These are cancers of the blood and bone marrow that affect the white blood cells. Examples include acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL).
5. Melanomas: These are malignant tumors that arise in the pigment-producing cells called melanocytes. Examples include skin melanoma and eye melanoma.
Causes and Risk Factors of Neoplasms
The exact causes of neoplasms are not fully understood, but there are several known risk factors that can increase the likelihood of developing a neoplasm. These include:
1. Genetic predisposition: Some people may be born with genetic mutations that increase their risk of developing certain types of neoplasms.
2. Environmental factors: Exposure to certain environmental toxins, such as radiation and certain chemicals, can increase the risk of developing a neoplasm.
3. Infection: Some neoplasms are caused by viruses or bacteria. For example, human papillomavirus (HPV) is a common cause of cervical cancer.
4. Lifestyle factors: Factors such as smoking, excessive alcohol consumption, and a poor diet can increase the risk of developing certain types of neoplasms.
5. Family history: A person's risk of developing a neoplasm may be higher if they have a family history of the condition.
Signs and Symptoms of Neoplasms
The signs and symptoms of neoplasms can vary depending on the type of cancer and where it is located in the body. Some common signs and symptoms include:
1. Unusual lumps or swelling
4. Weight loss
5. Change in bowel or bladder habits
6. Unexplained bleeding
7. Coughing up blood
8. Hoarseness or a persistent cough
9. Changes in appetite or digestion
10. Skin changes, such as a new mole or a change in the size or color of an existing mole.
Diagnosis and Treatment of Neoplasms
The diagnosis of a neoplasm usually involves a combination of physical examination, imaging tests (such as X-rays, CT scans, or MRI scans), and biopsy. A biopsy involves removing a small sample of tissue from the suspected tumor and examining it under a microscope for cancer cells.
The treatment of neoplasms depends on the type, size, location, and stage of the cancer, as well as the patient's overall health. Some common treatments include:
1. Surgery: Removing the tumor and surrounding tissue can be an effective way to treat many types of cancer.
2. Chemotherapy: Using drugs to kill cancer cells can be effective for some types of cancer, especially if the cancer has spread to other parts of the body.
3. Radiation therapy: Using high-energy radiation to kill cancer cells can be effective for some types of cancer, especially if the cancer is located in a specific area of the body.
4. Immunotherapy: Boosting the body's immune system to fight cancer can be an effective treatment for some types of cancer.
5. Targeted therapy: Using drugs or other substances to target specific molecules on cancer cells can be an effective treatment for some types of cancer.
Prevention of Neoplasms
While it is not always possible to prevent neoplasms, there are several steps that can reduce the risk of developing cancer. These include:
1. Avoiding exposure to known carcinogens (such as tobacco smoke and radiation)
2. Maintaining a healthy diet and lifestyle
3. Getting regular exercise
4. Not smoking or using tobacco products
5. Limiting alcohol consumption
6. Getting vaccinated against certain viruses that are associated with cancer (such as human papillomavirus, or HPV)
7. Participating in screening programs for early detection of cancer (such as mammograms for breast cancer and colonoscopies for colon cancer)
8. Avoiding excessive exposure to sunlight and using protective measures such as sunscreen and hats to prevent skin cancer.
It's important to note that not all cancers can be prevented, and some may be caused by factors that are not yet understood or cannot be controlled. However, by taking these steps, individuals can reduce their risk of developing cancer and improve their overall health and well-being.
Comparative effectiveness research
Journal of Comparative Effectiveness Research
Comparative Effectiveness Research Translation Network
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Browsing EB109 by Subject "Comparative Effectiveness Research"
Comparative effectiveness research: An opportunity for AAOS
Citation Form | JOURNAL-OF-COMPARATIVE-EFFECTIVENESS-RESEARCH | Newsletter | Citation Machine
Using Science to Improve the Nation's Health System: NIH's Commitment to Comparative Effectiveness Research | National...
A New Landscape for Comparative Effectiveness Research - Analysis Group
Time is of the essence'. PCORI moves to implement comparative effectiveness research, funding | PCORI
RDC - Data Hosting - United States Cancer Statistics
LocalControl: An R Package for Comparative Safety and Effectiveness Research. | J Stat Softw;96(4)2020. | MEDLINE | BVS...
Comparative Effectiveness of Coronavirus Vaccine in Preventing Breakthrough Infections among Vaccinated Persons Infected with...
EVERSANA's Value & Evidence Team's Work Tops List of Most Read Articles in 2021 in Journal of Comparative Effectiveness...
New perspective for pain control in neonates: a comparative effectiveness research - COME collaboration
Research Evaluation and Impact Assessment of ARRA Comparative Effectiveness Research Portfolio - Insight Policy Research
Clinical and translational research: Med
Academic Peer Detailing-The Preparation and Experience of Detailers Involved in a Project to Disseminate a Comparative...
Glossary | Agency for Healthcare Research and Quality
Comparative Effectiveness of BNT162b2 versus Ad26.COV2.S for the Prevention of COVID-19 among Dialysis Patients | medRxiv
Effectiveness Matters: Preventing pressure ulcers - Centre for Reviews and Dissemination, University of York
Systematic review on the comparative effectiveness of foot orthoses in patients with rheumatoid arthritis | Journal of Foot and...
Topics | AMCP.org
Brachytherapy (Radioactive Seed Implantation Therapy) in Prostate Cancer: Practice Essentials, Background, Indications
Understand meta-analyses in comparative effectiveness.
Coming of the Light: Integrator Top 10 from 2009 for Integrative Medicine/Integrated Health Care - Healthy.net
RFA-NS-23-027: Collaborative Opportunities for Multidisciplinary, Bold, and Innovative Neuroscience (COMBINE) (RM1 Clinical...
NIOSHTIC-2 Search Results - Full View
The Increasing Trend in Caesarean Section Rates: Global, Regional and National Estimates: 1990-2014 | PLOS ONE
Comparing Talk Therapy and Other Depression Treatments With Antidepressant Medicines | Effective Health Care (EHC) Program
PolitiFact | There's rationing in health care now, and there still would be under reform bill
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Evidence Summary: Cardiovascular Disease Risk: Screening With Electrocardiography | United States Preventive Services Taskforce
Research Articles - Dartmouth Atlas of Health Care
- The second most downloaded piece was a Research article on " Efficacy classifications of modern therapies in multiple sclerosis, " downloaded just shy of 3,000 times and published in late February 2021. (eversana.com)
- Within these systematic reviews, the effectiveness of custom-made FOs was compared to placebo/simple FOs or no FOs. (biomedcentral.com)
- Snowballing's effectiveness makes it best practice in systematic reviews despite being time-consuming and tedious. (jmir.org)
- Committee on Standards for Systematic Reviews of Comparative Effectiveness Research. (who.int)
- In response to the need for data to support comparative effectiveness research (CER), or patient-centered outcomes research, the Agency for Healthcare Research and Quality (AHRQ) and CDC's National Program of Cancer Registries (NPCR) developed a special data collection enhancement project to help answer specific CER questions through the development of analytic datasets. (cdc.gov)
- AHRQ Projects funded by the Patient-Centered Outcomes Research Trust Fund. (ahrq.gov)
- Engaging parent-child dyad and healthcare provider stakeholders in a patient-centered comparative effectiveness study. (cdc.gov)
- This issue of Effectiveness Matters summarises the evidence relating to the implementation of interventions to prevent pressure ulcers in hospital and community care settings. (york.ac.uk)
- These reviews have found convincing evidence of effectiveness for high-specification foam mattresses, 7 but not for standalone nutritional interventions 8 or for the application of topical agents over bony prominences. (york.ac.uk)
- The National Pharmaceutical Council (NPC) is a health policy research organization dedicated to the advancement of good evidence and science, and to fostering an environment in the United States that supports medical innovation. (npcnow.org)
- Results: Results from intervention effectiveness studies on hearing loss prevention do not provide evidence to support current practices. (cdc.gov)
- Direct evidence for cloth and medical mask efficacy and effectiveness in the community is limited. (who.int)
- 3. Since such a policy and plan should be based on solid evidence, it is vital to carry out beforehand a comprehensive assessment and anal ysis of the knowledge gap and the current state of research, information and knowledge manageme nt in each country. (who.int)
- DEPLOY, a matched-pair, group-randomized pilot comparative effectiveness trial involving two YMCA facilities in greater Indianapolis, compared the delivery of a group-based DPP lifestyle intervention by the YMCA with brief counseling alone (control). (cdc.gov)
- We aimed to provide a measure of comparative effectiveness of mRNA vaccines (BNT162b2 and mRNA-1273) against B.1.617.2 (Delta) versus B.1.1.7 (Alpha) VOCs, using a case-case study design. (cdc.gov)
- Methods This retrospective study compared the clinical effectiveness of Ad26.COV2.S (Janssen/Johnson and Johnson) to BNT162b2 among dialysis patients. (medrxiv.org)
- Conclusion In a large real-world cohort of dialysis patients, no difference was detected in the clinical effectiveness of BNT162b2 and Ad26.COV2.S, despite an inconsistent antibody response to the latter. (medrxiv.org)
- We developed a case-case study to compare mRNA vaccine effectiveness against Delta versus Alpha coronavirus variants. (cdc.gov)
- Determining the comparative effectiveness of CPAP versus CPAPflex in those subjects with OSA who have high nasal resistance through increasing adherence to therapy, thus allowing the WTC Health Program to make appropriate treatment decision with regard to these responders. (cdc.gov)
- We found significantly higher odds of vaccine breakthrough infection in Delta-infected patients than in Alpha-infected patients (odds ratio 1.96 [95% CI 1.22-3.14]), suggesting lower effectiveness of the mRNA vaccines in preventing infection with the Delta variant. (cdc.gov)
- Early reports of vaccine effectiveness indicate a high protection for mRNA vaccines against infection and disease ( 5 , 6 ) and a reduced viral load in the vaccinated case-patients ( 7 , 8 ). (cdc.gov)
- However, reports of vaccine effectiveness against Delta have shown decreased protection of the vaccines compared with the Alpha variant ( 2 , 9 ). (cdc.gov)
- Because individual vaccines may be differentially available or acceptable to patients, it is important to understand comparative effectiveness of other vaccines, such those based on adeno-virus technologies. (medrxiv.org)
- To date, there are no comparative effectiveness data for these vaccines on clinical outcomes. (medrxiv.org)
- A type of health care research that compares the results of one approach for managing a disease to the results of other approaches. (ahrq.gov)
- Since then, a flurry of leading integrative healthcare professional and academic associations weighed in for more attention to pragmatic, real-world, effectiveness approaches. (healthy.net)
- This defined research goal must only be achievable by an interdisciplinary team approach involving innovative combination of distinct disciplines and/or intellectual viewpoints, synergy in expertise and approaches, and well-managed team interactions. (nih.gov)
- Tackling the most ambitious goals and challenges of modern neuroscience research is increasingly dependent on collaborative approaches that leverage expertise and advances across multiple disciplines, an ever-increasing knowledgebase, and a broad armamentarium of technologies. (nih.gov)
- In the proposal, please thoroughly explain your research need for access to restricted-use variables, your analytic plan, how you intend to report your results, and the exact output you need for your near final product (e.g., paper, journal article or presentation). (cdc.gov)
- Proposal amendments, including changes to the research team or minor adjustments to research questions or output, require an updated proposal and full review by Review Committee. (cdc.gov)
- After the proposal is approved, all members of the research team are required to complete the Confidentiality Training. (cdc.gov)
- The first is a proposal to expand comparative effectiveness research. (politifact.com)
- The YMCA, which was engaged before the development of the research grant proposal, collaborated with researchers at IUSM throughout the study. (cdc.gov)
- Read the commentary in the Journal of the American Medical Association on comparative effectiveness research (CER) and NIH's leadership role by NIH Director Francis Collins and Dr. Michael Lauer. (nih.gov)
- If you work in the field of Health Economics and Outcome Research (HEOR) in the life sciences industry, you know just how valuable the Journal of Comparative Effectiveness Research (JCER) is. (eversana.com)
- The evaluation catalogued how CER funding was invested to achieve the vision of the Federal Coordinating Council on Comparative Effectiveness Research, develop tools for ongoing assessment of the ARRA CER portfolio, and provide guidance to the U.S. Department of Health and Human Services (HHS) regarding future CER evaluations and investments. (insightpolicyresearch.com)
- This 3-year study provided the Office of the Assistant Secretary for Planning and Evaluation with a formative, short-term assessment of the American Recovery and Reinvestment Act (ARRA)-funded comparative effectiveness research (CER) portfolio. (insightpolicyresearch.com)
- The objectives of the present study were to summarize the comparative effectiveness of FOs in the treatment of various foot problems in patients with rheumatoid arthritis, on the primary outcomes foot function and foot pain, and the secondary outcomes physical functioning, health related quality of life, compliance, adverse events, the costs of FOs and patient satisfaction. (biomedcentral.com)
- The objective of this study was to evaluate the effectiveness of a lengthened multi-disciplinary team consultation in primary care in reducing anxiety and depression in mothers. (nih.gov)
- Aim: Describe engagement activities in a comparative effectiveness study evaluating two interventions for promoting psychosocial health among youth ages 10-17 who have recently experienced a nonintentional injury. (cdc.gov)
- Conclusion: Results highlight diverse methods of engaging patient and professional stakeholders, critical recommendations for improving study engagement and retention, and future directions for this patient-engaged comparative effectiveness research. (cdc.gov)
- We are pleased to announce that Insight Policy Research was acquired by Westat, effective June 15, 2022. (insightpolicyresearch.com)
Agency for Hea3
- This information comes from a research report that was funded by the Agency for Healthcare Research and Quality, a Federal Government agency. (ahrq.gov)
- They should not be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services. (uspreventiveservicestaskforce.org)
- Rockville, MD: Agency for Healthcare Research and Quality. (bvsalud.org)
- However, a broad variation in FOs is used, both in clinical practice and in research. (biomedcentral.com)
- A broad variation in FOs is used in the treatment of specific RA-related foot problems, both in clinical practice and research. (biomedcentral.com)
- Here is the 2009 Integrator Top 10 for integrative policy, practice, research and professional activity. (healthy.net)
- Dr. Jones' research focuses on key areas of digital health including the use of electronic health records (EHRs) to support innovation in care process redesign, the development of tools and processes for implementing shared decision-making and patient-reported data collection in routine care, and deploying and evaluating health IT tools in "real-world" clinical practice settings. (sutterhealth.org)
- Dr. Jones received his PhD in health services research from the Johns Hopkins University Bloomberg School of Public Health, his MBA from the Marriott School of Management at Brigham Young University, and his BS in physiology from the University of California, Davis. (sutterhealth.org)
- Our combined experience now offers expanded expertise in health, education, and social policy as well as deeper methodological skills in survey research, evaluation, data analytics, and technical assistance. (insightpolicyresearch.com)
- Most reported interventions focus on the use of hearing protectors, and effectiveness depends on the quality of the implementation of prevention programs. (cdc.gov)
- Methods A systematic review and meta-analysis, including primary research studies of any method published in peer-reviewed journals. (bmj.com)
- Background Extensive research has been conducted into the effects of feedback interventions within many areas of healthcare, but prehospital emergency care has been relatively neglected. (bmj.com)
- The NICE guideline further states that additional research is needed on debridement techniques, negative wound pressure therapy, risk assessment in children, pressure redistribution devices, and the optimum position and frequency for repositioning patients. (york.ac.uk)
- Genetic testing for suicide risk assessment: Theoretical premises, research challenges and ethical concerns. (cdc.gov)
- This information is from research on adults. (ahrq.gov)
- Research participants were adults who attended a diabetes risk-screening event at one of two semi-urban YMCA facilities and had a BMI (kg/m2) greater than 24, two or more risk factors for diabetes, and a random capillary blood glucose concentration of 110-199 mg/dL. (cdc.gov)
- Click on a year to view research articles published that year. (dartmouthatlas.org)
- Comparative effectiveness also can compare types of surgery or other kinds of medical procedures and tests. (ahrq.gov)
- Themes of effectiveness, comparative effectiveness, medical costs and the role of research in reform are on the table. (healthy.net)
- To assess the effectiveness of cloth and medical masks for preventing SARS-CoV-2 transmission in community settings. (who.int)
- The primary outcome was the comparative rate of COVID-19 considered over 3 follow-up intervals: weeks 1-3, 4-6, and ≥ 7 post-vaccination. (medrxiv.org)
- Two other types of talk therapy (interpersonal therapy and psychodynamic therapy) might also work as well as antidepressants, but more research is needed to know for sure. (ahrq.gov)
- The Act called on the Institute of Medicine to recommend comparative effectiveness research priority topics. (cdc.gov)
- Definitive high quality RCTs, with adequate sample sizes and long-term follow-up, are needed to investigate the comparative (cost-) effectiveness of different kinds of foot orthoses for the treatment of foot problems related to rheumatoid arthritis. (biomedcentral.com)
- Further research is needed to provide guidance and frameworks supporting better design and evaluation of feedback interventions within EMS. (bmj.com)
- We're proud of what we've done to date, and excited about our growing team's capabilities to deliver world-class research. (eversana.com)
- Validating this potential reduction of vaccine effectiveness against the Delta VOC is critical to inform further public health measures, particularly as the variant becomes globally dominant. (cdc.gov)
- Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts. (bvsalud.org)
- While designed and appropriate for use in comparative safety and effectiveness research involving medicine and the life sciences , the package can be used in other situations involving outcomes with multiple confounders. (bvsalud.org)
- Dr. Jones directs Sutter Health's Health Care Solutions team, and is a Principal Investigator at the Sutter Health Center for Health Systems Research (East Campus, currently operating as Sutter's Research Development and Dissemination). (sutterhealth.org)
- 1 - 4 As such, efforts to vaccinate these patients and understand the effectiveness of vaccinations in this cohort are critical. (medrxiv.org)
- The WHO COVID-19 Research Database is a resource created in response to the Public Health Emergency of International Concern (PHEIC). (bvsalud.org)