Conduct and synthesis of systematic research comparing interventions and strategies to prevent, diagnose, treat, and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances. (hhs.gov/recovery/programs/cer/draftdefinition.html accessed 6/12/2009)
An agency of the PUBLIC HEALTH SERVICE established in 1990 to "provide indexing, abstracting, translating, publishing, and other services leading to a more effective and timely dissemination of information on research, demonstration projects, and evaluations with respect to health care to public and private entities and individuals engaged in the improvement of health care delivery..." It supersedes the National Center for Health Services Research. The United States Agency for Health Care Policy and Research was renamed Agency for Healthcare Research and Quality (AHRQ) under the Healthcare Research and Quality Act of 1999.
Public Law No: 111-5, enacted February 2009, makes supplemental appropriations for job preservation and creation, infrastructure investment, energy efficiency and science, assistance to the unemployed, and State and local fiscal stabilization, for fiscal year ending September 30, 2009.
Design of patient care wherein institutional resources and personnel are organized around patients rather than around specialized departments. (From Hospitals 1993 Feb 5;67(3):14)
An Act prohibiting a health plan from establishing lifetime limits or annual limits on the dollar value of benefits for any participant or beneficiary after January 1, 2014. It permits a restricted annual limit for plan years beginning prior to January 1, 2014. It provides that a health plan shall not be prevented from placing annual or lifetime per-beneficiary limits on covered benefits. The Act sets up a competitive health insurance market.
A clinical study in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study).
Media that facilitate transportability of pertinent information concerning patient's illness across varied providers and geographic locations. Some versions include direct linkages to online consumer health information that is relevant to the health conditions and treatments related to a specific patient.
An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)
A plan for collecting and utilizing data so that desired information can be obtained with sufficient precision or so that an hypothesis can be tested properly.
The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.
Treatments which are undergoing clinical trials or for which there is insufficient evidence to determine their effects on health outcomes; coverage for such treatments is often denied by health insurers.
Innovation and improvement of the health care system by reappraisal, amendment of services, and removal of faults and abuses in providing and distributing health services to patients. It includes a re-alignment of health services and health insurance to maximum demographic elements (the unemployed, indigent, uninsured, elderly, inner cities, rural areas) with reference to coverage, hospitalization, pricing and cost containment, insurers' and employers' costs, pre-existing medical conditions, prescribed drugs, equipment, and services.
The act of regarding attentively and studying facts and occurrences, gathering data through analyzing, measuring, and drawing conclusions, with the purpose of applying the observed information to theoretical assumptions. Observation as a scientific method in the acquisition of knowledge began in classical antiquity; in modern science and medicine its greatest application is facilitated by modern technology. Observation is one of the components of the research process.
Financial support of research activities.
Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Evaluation procedures that focus on both the outcome or status (OUTCOMES ASSESSMENT) of the patient at the end of an episode of care - presence of symptoms, level of activity, and mortality; and the process (ASSESSMENT, PROCESS) - what is done for the patient diagnostically and therapeutically.
The field of information science concerned with the analysis and dissemination of medical data through the application of computers to various aspects of health care and medicine.
The purposes, missions, and goals of an individual organization or its units, established through administrative processes. It includes an organization's long-range plans and administrative philosophy.
Decisions, usually developed by government policymakers, for determining present and future objectives pertaining to the health care system.
The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.
Conditional probability of exposure to a treatment given observed covariates.
A subspecialty of internal medicine concerned with the study of neoplasms.
The circulation or wide dispersal of information.
A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.
Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
Patient involvement in the decision-making process in matters pertaining to health.
The broad dissemination of new ideas, procedures, techniques, materials, and devices and the degree to which these are accepted and used.
The concept concerned with all aspects of providing and distributing health services to a patient population.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
Federal program, created by Public Law 89-97, Title XVIII-Health Insurance for the Aged, a 1965 amendment to the Social Security Act, that provides health insurance benefits to persons over the age of 65 and others eligible for Social Security benefits. It consists of two separate but coordinated programs: hospital insurance (MEDICARE PART A) and supplementary medical insurance (MEDICARE PART B). (Hospital Administration Terminology, AHA, 2d ed and A Discursive Dictionary of Health Care, US House of Representatives, 1976)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
A type of analysis in which subjects in a study group and a comparison group are made comparable with respect to extraneous factors by individually pairing study subjects with the comparison group subjects (e.g., age-matched controls).
A measurement index derived from a modification of standard life-table procedures and designed to take account of the quality as well as the duration of survival. This index can be used in assessing the outcome of health care procedures or services. (BIOETHICS Thesaurus, 1994)
The provision of monetary resources including money or capital and credit; obtaining or furnishing money or capital for a purchase or enterprise and the funds so obtained. (From Random House Unabridged Dictionary, 2d ed.)
The aggregate business enterprise of agriculture, manufacture, and distribution related to tobacco and tobacco-derived products.
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

The policies and politics of creating a comparative clinical effectiveness research center. (1/390)

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'Marginal medicine': targeting comparative effectiveness research to reduce waste. (2/390)

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Developing a policy for second-generation antipsychotic drugs. (3/390)

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Comparative effectiveness research for antipsychotic medications: how much is enough? (4/390)

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Does telemonitoring of patients--the eICU--improve intensive care? (5/390)

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Measurement of and reward for efficiency In California's pay-for-performance program. (6/390)

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Is it time to reexamine the patent system's role in spending growth? (7/390)

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Gemcitabine for the treatment of metastatic breast cancer. (8/390)

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TY - JOUR. T1 - Comparative effectiveness research in liver transplantation. T2 - Crossing the cost and quality chasm. AU - Jay, Colleen L.. AU - Skaro, Anton I. PY - 2013/1/1. Y1 - 2013/1/1. UR - http://www.scopus.com/inward/record.url?scp=84886944223&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84886944223&partnerID=8YFLogxK. U2 - 10.2217/cer.12.65. DO - 10.2217/cer.12.65. M3 - Review article. C2 - 24236515. AN - SCOPUS:84886944223. VL - 2. SP - 7. EP - 9. JO - Journal of Comparative Effectiveness Research. JF - Journal of Comparative Effectiveness Research. SN - 2042-6305. IS - 1. ER - ...
Comparative Effectiveness Research is an international, peer reviewed, open access journal that strives to cover this emerging field. Comparative effectiveness research (CER) is a PICOT (Population, Intervention, Comparison, Outcome, Time) question-driven, systematic process of investigation; it utilizes the well-characterized design of research synthesis, validated methodology for assessing the evidence and data analysis, which includes acceptable sampling and meta-analysis. CER assembles the best available evidence for ensuring effectiveness-focused, patient-centered and evidence-based medicine, dentistry, nursing and allied disciplines. CER is the critical and timely process of translational healthcare; it evinces the most reliable evidence to compare the advantages, disadvantages and expenditure for an intervention with other available options for the prevention, diagnosis, treatment and monitoring of a clinical condition. CER amalgamates patients, clinicians, caregivers and other stakeholders to
Abstract (from Health Affairs): Medicines current evidence base is insufficient for many of the decisions made daily by clinicians, patients, purchasers, and policy makers. The Patient-Centered Outcomes Research Institute (PCORI) represents an effort by the US government to address this shortcoming by funding comparative effectiveness research (CER). Prioritizing that research will be a critical first step. To better understand components of an optimal process, NPC reviewed the literature and conducted interviews regarding the prioritization efforts of leading public and private health organizations in the United States and abroad. From this review, NPC proposes a framework for prioritization, poses and answers key questions, and makes recommendations regarding application of that framework. NPC also recommends that during the priority-setting process, there should be transparent conversations among those who make decisions about the priorities and the public.. ...
Find and compare average compensation for Patient-Centered Outcomes Research Institute jobs such as Chief of Staff, Communications Manager, HR Analyst. Search our database of Patient-Centered Outcomes Research Institute job listings to find the top 100K jobs hiring in your area.
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Recovery Act 2009 Limited Competition OS ARRA: Comparative Effectiveness Research to Optimize Prevention and Healthcare Management for the Complex Patient (R21) RFA-HS-10-009. AHRQ
The prevalence of obesity and diabetes in older adults is increasing. Because older adults are often portrayed as less likely to change long-standing health behaviors, health promotion in this age group has lagged behind others. In fact, little attention has been given to the importance of diabetes prevention in community-dwelling older adults through the implementation of programs that promote healthy nutrition, increase physical activity and improve self-management. The Diabetes Prevention Program (DPP), which demonstrated the benefit of modest weight loss on the reduction of diabetes risk (58% overall reduction with a 71% reduction in the older population), has yet to be translated into widespread public health practice.. The overall objective of this protocol is to implement evidence-informed, innovative interventions to increase adoption of findings from comparative effectiveness research (CER) for diabetes management and prevention in South Florida older veterans. Specifically, the ...
The main thrust of this con article is to state that the area of portable monitoring and home-based treatment of sleep apnea direly needs comparative effectiveness research (CER) with cost-efficacy and tangible patient outcomes measurements before widespread institution into real-world practice. In the absence of such CER, currently, there are few modeling studies that are not favorable toward portable monitoring and home-based treatment initiation, and that requires careful attention.16-18. Pietzche and colleagues recently published their Markov model-based study which used a hypothetical model applied to 50-year-old men with a 50% chance of having moderate-severe sleep apnea.17 They performed 10-year and lifetime incremental cost-effectiveness ratio projections for laboratory based studies and portable monitoring.17 They factored rates and cost of cardiovascular events and motor vehicle accidents, health-related quality of life, CPAP adherence, and failure of portable monitoring or therapy. ...
Agencies in Australia, France, Germany, and the U.K. have comparative effectiveness research agencies that offer lessons for the United States.
Dr. Steven Pearson, president of Institute for Clinical and Economic Review, explains how private and public payers might use comparative effectiveness research, particularly with the expected influx of new information from federal sources. NPC spoke with Dr. Pearson at the Drug Information Association Annual Meeting in June 2011.. ...
In the aftermath of the Supreme Courts landmark Affordable Care Act ruling, leading health care researchers will discuss strategies for analyzing large population databases to conduct comparative effectiveness research (CER) July 13 at Rice Universitys Baker Institute for Public Policy.
For all its costs, flaws, and inequities, American health care is fundamentally rooted in a belief that treatment should be based on solid scientific research. To this end, between 2003 and 2010, three different federal laws were enacted, the most recent being the Affordable Care Act of 2010, that mandated new federal investments in a type of clinical research called comparative effectiveness research (CER) - research into what works best in medical care.
Our work will include comparative effectiveness research, with an emphasis on causal inference methods for complex longitudinal data from both observational studies and randomized trials, e.g. to assess effects of interventions on cardiovascular disease, cancer, and others. The research will mainly be based on data from Swedish population and health data registers.
But the truth is: this trial never would have seen the light of day if it werent for industry. Note that St. Jude Medical paid $20 million and Biosense Webster paid $18 million toward the trial, while the government could only foot 35% ($18 million) of the costs for the trial. Some will consider this an efficient use of government funds. Others will point to the governments new paradigm for requiring significant industry sponsorship to fund their comparative effectiveness research (CER) trials as opening the potential for the development of pay to play relationships to develop between government and industry. One only has to look to the FDAs recent challenges at separating themselves from industry influence to see the potential for conflict ...
But the truth is: this trial never would have seen the light of day if it werent for industry. Note that St. Jude Medical paid $20 million and Biosense Webster paid $18 million toward the trial, while the government could only foot 35% ($18 million) of the costs for the trial. Some will consider this an efficient use of government funds. Others will point to the governments new paradigm for requiring significant industry sponsorship to fund their comparative effectiveness research (CER) trials as opening the potential for the development of pay to play relationships to develop between government and industry. One only has to look to the FDAs recent challenges at separating themselves from industry influence to see the potential for conflict ...
After a prolonged debate over government-sponsored comparative effectiveness research, Congress decided to authorize it in the Affordable Care Act, but to strictly forbid CMS from considering the results in coverage decisions. It turns out, however, that there are other ways to incorporate the results into determinations of which services will be provided - without rationing care.
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Meystre S, Gouripeddi R, Tieder J, Simmons J, Srivastava R, Shah S. Enhancing Comparative Effectiveness Research With Automated Pediatric Pneumonia Detection in a Multi-Institutional Clinical Repository: A PHIS+ Pilot Study. J Med Internet Res. 2017 May 15;19(5):e162.. ...
Mood stabilizers, medications that prevent future mood episodes, are the foundation for treatment of bipolar disorder. While all published bipolar disorder treatment guidelines recommend that pharmacotherapy should include mood stabilizers for long-term maintenance treatment, no randomized comparative effectiveness studies have examined the real-world advantages and disadvantages of the newer second generation antipsychotic (SGA) mood stabilizers compared to the classic mood stabilizers, such as lithium (Li). No studies have looked at the effectiveness of SGAs compared to mood stabilizers when used in the context of other medications required to manage bipolar patients, since bipolar disorder patients take a median of 3 medications for optimal outcomes. Quetiapine (QTP) is the most extensively studied, broadly efficacious and the most widely prescribed SGA for bipolar disorder. The classic mood stabilizer Li has the largest evidence base for treating bipolar disorder, but has been largely ...
1) Comparative effectiveness research and 2) ACGME proposals for work duty hours. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Michael Benatar interviews Dr. Jacqueline French about her paper on comparative effectiveness research. In the next segment, Dr. Ryan Overman is reading our e-Pearl of the week about Guillain-Barré-like syndrome with thallium poisoning. In the next part of the podcast Dr. Ted Burns interviews Dr. Lori Schuh about ACGME recommendations for work duty hours for Read More 1) Comparative effectiveness research and 2) ACGME proposals for work duty hours. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Michael Benatar interviews Dr. Jacqueline French about her paper on ...
TY - JOUR. T1 - Comparative effectiveness review of treatment options for pituitary microadenomas in acromegaly. T2 - Clinical article. AU - Marko, Nicholas F.. AU - Lasota, Emily. AU - Hamrahian, Amir. AU - Weil, Robert J.. PY - 2012/9/1. Y1 - 2012/9/1. N2 - Object. Acromegaly, a syndrome of excess growth hormone (GH) secretion typically caused by a GH-secreting pituitary adenoma, reduces life expectancy by approximately 10 years when left untreated. Treatment of acromegaly involves combinations of one or more discrete therapeutic modalities to achieve biochemical control. Unfortunately, data capable of informing decisions among alternate management strategies are presently lacking. Methods. The authors performed a comparative effectiveness research (CER) review integrating efficacy, cost, and quality of life (QOL) analysis for treatment strategies comprising various combinations of surgery, radiotherapy, stereotactic radiosurgery, and pharmacotherapy in patients with acromegaly caused by a ...
Group Health has been approved for two research awards from the Patient-Centered Outcomes Research Institute (PCORI) to study ways to improve care for back pain and to connect patients with community resources. The projects are part of a portfolio of patient-centered comparative clinical effectiveness research that addresses PCORIs National Priorities for Research and Research Agenda.. ...
Under some all-powerful government CER panel would Clinton have received the stents? What does CER tell us about the best treatment for ACS? We have comparative effectiveness studies out the wazoo on this issue alone and they would be too numerous to mention here. For the most part these studies are compiled and evaluated in the latest ACC/AHA guidelines for unstable angina/NSTEMI, which is what Clinton most likely had. Under these guidelines either an initial conservative or invasive strategy is allowed, and if the patient stabilizes clinically a stress test is recommended before cardiac catheterization. Positive cardiac markers and ST segment or T wave changes suggest, but do not mandate, an initial invasive strategy under the guidelines. My summary is a gross oversimplification. Be assured the government will oversimplify even more. The Fox piece is distorted and non-informative but suffice it to say that in an era where government panels wrest EBM from the hands of physicians Clinton (or ...
Comparative Effectiveness Review Number 134 Pharmacotherapy for Adults With Alcohol- Use Disorders in Outpatient Settings Comparative Effectiveness Review Number 134 Pharmacotherapy for Adults With Alcohol-Use
The Patient-Centered Outcomes Research Institute (PCORI) is a United States-based non-governmental institute created as part of a modification to the Social Security Act by clauses in the Patient Protection and Affordable Care Act. It is a government-sponsored organization charged with investigating the relative effectiveness of various medical treatments. Medicare may consider the Institutes research in the determining what sorts of therapies it will cover. PCORI was established by the 2010 Patient Protection and Affordable Care Act. It is a 501(c)(1) organization. PCORI is charged with examining the relative health outcomes, clinical effectiveness, and appropriateness of different medical treatments by evaluating existing studies and conducting its own. Its nineteen-member board includes patients, physicians, nurses, hospitals, drug makers, device manufacturers, insurers, payers, government officials and health experts. It will not have the power to mandate or even endorse coverage rules or ...
1. Do you feel it is better to allow individuals the freedom to choose any type of (or no) health insurance coverage available to them or to increase government involvement in a persons/familys healthcare via mandates, such as the ACA and/or the government as a single insurer for all residents. Why?. 2. Discuss the mission of the Patient-Centered Outcomes Research Institute (PCORI) and the Center for Medicare & Medicaid Innovation (CMMI).. 3. If you could reform the malpractice or tort laws, what types of changes would you make? When do you feel it is appropriate for someone to claim damages from medical procedures or treatment? Do you feel there should be a cap on the payments, and if so, how would you decide what that cap would be? What are all the different costs involved in medical malpractice suites? Is it easier to talk about tort reform than to actually try to define it?. 4. The rights of people once they have been incarcerated can be a controversial topic of discussion. Discuss the ...
Current Membership of the Patient-Centered Outcomes Research Institute (PCORI) Governing Board. Following are brief biographies of the current members of the PCORI Board of Governors.. Debra Barksdale, PhD, RN, is Professor and Associate Dean of Academic Programs at the Virginia Commonwealth University in Richmond, VA. She is a researcher, certified nurse practitioner, and educator. Her research program focuses on psychological and physical stress, coping, and cardiovascular responses in African-Americans. She is a Fellow of the American Academy of Nurse Practitioners and the American Academy of Nursing. She received a BS in nursing from the University of Virginia, a masters in nursing from Howard University, a post-masters in teaching from the University of Pennsylvania, and a PhD in Nursing Research from the University of Michigan. Dr. Barksdale was appointed in September 2010 for a 2-year term and reappointed in September 2012 for a 6-year term.. Kerry Barnett, JD, (Vice Chair) is President ...
These are not new concepts to anesthesiologists. However, much like the practice of medicine as a whole, many of our clinical decisions are not rooted in large comparative effectiveness trials. Efficacy trials are typically small, early-stage randomized controlled trials of a treatment. They often enroll a specific, high-risk patient population to maximize statistical power and require detailed protocols mandating specific care patterns and ideal use of the studied intervention. An example would be the van den Berghe et al. 6 trial of intensive insulin therapy in surgical intensive care unit patients, which demonstrated a profound mortality and morbidity benefit to targeting blood glucose levels less than 110 mg/dl. This proof-of-concept study was then rapidly extrapolated to become a mainstay of critical care protocols. A multicenter study enrolling more than 6,000 heterogeneous patients under typical care settings demonstrated lower mortality using conventional blood glucose targets.7 These ...
This query was raised by provincial health plan decision-makers earlier in 2012. Thiazide diuretics (i.e. hydrochlorothiazide) have been shown to be at least as effective as calcium channel blockers (CCBs) (e.g. amlodipine), angiotensin converting enzyme (ACE) inhibitors (e.g. lisinopril) and angiotensin receptor blockers (ARBs) (e.g. losartan). In response to this query, we will evaluate the comparative effectiveness of antihypertensive treatments among older adults without diabetes, focusing on thiazides monotherapy compared with other monotherapy.. Q2. What is the comparative effectiveness and safety of sitagliptan and NPH insulin for the management of type 2 DM not controlled by metformin plus sulfonylurea ...
Dr. Testa and colleagues are developing quantitative and health information technology methods and processes relating to the measurement and analysis of expanded patient outcomes (quality of life, cost-effectiveness and risk-benefit) for clinical, pharmacoeconomic, pharmacoepidemiologic, quality of care and comparative effectiveness research studies with particular application to primary care, cardiovascular disease, HIV, and diabetes.. Quality of Life, Patient Satisfaction, Clinical Decision Making and Comparative Effectiveness Research Dr. Testa is working on analytical, statistical and health information methods for conducting health outcomes and comparative effectivness research for pharmaceutical drug development, disease management, quality of care programs and primary care and physician subspecialty practice management. As part of this methodologic work, she is analyzing a comprehensive database of patients who have participated in large-scale clinical trials of antihypertensive and ...
The Distributed Ambulatory Research in Therapeutics Network (DARTNet) is a federated network of electronic health data from 8 organizations representing more than 500 clinicians and more than 400 000 patients. DARTNet was designed to increase knowledge of the comparative effectiveness of prescriptio …
FDA. Patient-reported outcome measures: Use in medical development to support labeling claims. 2009. From http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM193282.pdf.. This guidance describes how the Food and Drug Administration (FDA) reviews and evaluates existing, modified, or newly created patient-reported outcome (PRO) instruments used to support claims in approved medical product labeling.. Basch E, et al. Recommendations for incorporating patient-reported outcomes into clinical comparative effectiveness research in adult oncology. J Clin Oncol. 2012; 30(34): 4249-55. PMID: 23071244.. ABSTRACT: Examining the patients subjective experience in prospective clinical comparative effectiveness research (CER) of oncology treatments or process interventions is essential for informing decision making. Patient-reported outcome (PRO) measures are the standard tools for directly eliciting the patient experience. There are currently no widely accepted standards ...
Purpose - Little is known about the comparative effects of common oral antidiabetic drugs ([OADs] metformin, sulfonylureas, or thiazolidinediones [THZs]) on chronic kidney disease (CKD) outcomes in patients newly diagnosed with type 2 diabetes (T2DM) and followed in community primary care practices. Electronic health records (EHRs) were used to evaluate the relationships
case-control studies [mh] OR cohort studies [mh] OR cross-over studies [mh] OR epidemiologic studies [mh:noexp] OR cross-sectional studies [mh] OR evaluation studies as topic [mh] OR meta-analysis as topic [mh] OR practice guidelines as topic [mh] OR case control [tw] OR case controlled [tw] OR case controls [tw] OR cohort [tw]OR cohorts [tw] OR follow-up [tw] OR followup [tw] OR longitudinal [tw] OR matched-pair analysis [mh] OR observational studies [tw] OR observational study [tw] OR multicenter study [pt]) AND ((comparative study [pt] OR compare [tw] OR compares [tw] OR compared [tw] OR comparing [tw] OR comparison [tw] OR comparative [tw] OR effective [tw] OR effectiveness [tw] OR versus [ti] OR vs [ti]) AND (activities of daily living [mh] OR benefit [tw] OR benefits [tw] OR budgets [mh] OR chronic disease [mh] OR clinical trials data monitoring committees [mh] OR cognitive function [tw] OR ec [sh] OR death [mh] OR diffusion of innovation [mh] OR discharge [tw] OR economics, pharmaceutical ...
The mission of the MDEpiNet Public Private Partnerships is to develop and implement innovative methods and national/international infrastructure for robust studies and surveillance to improve our understanding of medical device safety and effectiveness throughout device life-cycle. Our main objectives are to improve how medical device information is utilized throughout the life cycle of a device and to synthesize evidence on how medical devices are used throughout their life cycle. To accomplish our mission and objectives we have brought together an array of diverse stakeholders, including other government agencies, academia, health care industry organizations, and patient and consumer groups. These stakeholders bring to the table strategic resources, skills, and expertise from a variety of domains and requires participation from all . Read More... ...
Seven studies with a total number of 9618 patients (mainly composed of non-ST elevated myocardial infarction/NSTEMI) were included. This analysis showed mortality to be similarly observed between enoxaparin and fondaparinux with OR: 1.05, 95% CI: 0.67-1.63; P = 0.84. Myocardial infarction (MI) and stroke were also not significantly different throughout different follow up periods. However, minor, major and total bleeding were significantly lower with fondaparinux (OR: 0.40, 95% CI: 0.27-0.58; P = 0.00001), (OR: 0.46, 95% CI: 0.32-0.66; P = 0.0001) and (OR: 0.47, 95% CI: 0.37-0.60; P = 0.00001) respectively during the 10-day follow up period. Even during a follow up period of 30 days or a midterm follow up, major and minor bleeding still significantly favored fondaparinux in comparison to enoxaparin. ...
The idea of CER is that researchers and scientists gather evidence and compare surgeries, medical devices, drugs, tests, or health care services, and weigh the
BACKGROUND: Adverse outcomes and resource use rates are high after hip fracture surgery. Peripheral nerve blocks could improve outcomes through enhanced
This trial is comparing the efficacy of immediate treatment with fosfomycin tromethamine [Monuril; Pierre Favre]versus symptomatic relief with ibuprofen
TY - JOUR. T1 - Directions for Effectiveness Research to Improve Health Services for Late-Life Depression in the United States. AU - Hoeft, Theresa J.. AU - Hinton, W Ladson. AU - Liu, Jessica. AU - Unützer, Jürgen. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Considerable progress has been made in the treatment of late-life depression over the past 20 years, yet considerable gaps in care remain. Gaps in care are particularly pronounced for older men, certain racial and ethnic minority groups, and those with comorbid medical or mental disorders. We reviewed the peer-reviewed literature and conducted interviews with experts in late-life depression to identify promising directions for effectiveness research to address these gaps in care. We searched the PubMed, PsychInfo, and CINHAL databases between January 1, 1998, through August 31, 2013, using terms related to late-life depression and any of the following: epidemiology, services organization, economics of care, underserved groups including health ...
In just a few days a new Obamacare tax-that will double the following year-will kick in to fund comparative effectiveness research thats supposed to help the government save money by finding ways to ration healthcare.. This is crazy; a semi-secret tax so the feds have cash to pay bureaucrats to examine everyones health records and, in turn, the government can save money by cutting back on care. The official plan, as noted by a national news wire this week, is to conduct research to find out which drugs, medical procedures, tests and treatments work best. Its part of a little-known provision of the presidents socialist takeover of the nations healthcare system.. Who will conduct this valuable research? A new quasi-governmental agency (Patient-Centered Outcomes Research Institute or PCORI) created by Obamacare to provide information about the best available evidence to help patients and their health care providers make more informed decisions. PCORI claims its research is intended to ...
Part of the mission of Health Outcomes Research in Medicine is to present evidence from outcomes research to help with decisions about which treatments to pursue and the efficacy of those treatments. In many instances, these decisions may involve comparisons of relative treatment costs in addition to relative treatment efficacy.Comparative effectiveness research (CER) has
OBJECTIVES: The purpose of this study was to compare self-reported pain and improvement of patients with symptomatic, magnetic resonance imaging-confirmed, lumbar disk herniations treated with either high-velocity, low-amplitude spinal manipulative therapy (SMT) or nerve root injections (NRI). METHODS: This prospective cohort comparative effectiveness study included 102 age- and sex-matched patients treated with either NRI or SMT. Numerical rating scale (NRS) pain data were collected before treatment. One month after treatment, current NRS pain levels and overall improvement assessed using the Patient Global Impression of Change scale were recorded. The proportion of patients, improved or worse, was calculated for each treatment. Comparison of pretreatment and 1-month NRS scores used the paired t test. Numerical rating scale and NRS change scores for the 2 groups were compared using the unpaired t test. The groups were also compared for improvement using the χ(2) test. Odds ratios with ...
Due to their condition, dialysis patients have limited access to inpatient and outpatient mental health (MH) treatment. The primary goal of this project is to establish a patient-caregiver-clinician-researcher partnership to develop a patient-centered comparative effectiveness research study that will identify potentially effective mechanisms for increasing access to and utilization of MH treatment for dialysis patients.
Drugs commonly used to treat high blood pressure, and prevent heart attacks and strokes, are associated with significantly worse cardiovascular outcomes in hypertensive African Americans compared to whites, according to a new comparative effectiveness research study led by researchers in the Department of Population Health at NYU Langone Medical Center and published in the Journal of the American College of Cardiology.
Our collective experience suggests that successful implementation of a patient- and stakeholder- engaged research paradigm involves: (1) defining the roles and process for the incorporation of input; (2) identifying the particular patients and stakeholders to build a foundation of key stakeholders who appropriately represent the target treatment population and its caregivers; (3) engaging patients and stakeholders so they appreciate the value of their own participation and have personal investment in the research process; and (4) overcoming barriers and challenges that arise and threaten the productivity of the collaboration. Engaging patients may include educating them so they understand the research process and how it is connected to changes in clinical practice, and are therefore equipped to make meaningful contributions (31). Foundations of trust and mutual respect are key elements to being able to successfully navigate all of the foreseeable and unforeseeable challenges that present ...
Section 6301(f)(2) of the Patient Protection and Affordable Care Act (PPACA) requires the Comptroller General to consider and disclose any conflicts of interest in appointing the Board of Governors on GAOs Web site.. Section 6301(a)(3) of PPACA defines conflict of interest as: [A]n association, including a financial or personal association, that have the potential to bias or have the appearance of biasing an individuals decision in matters related to the Institute or the conduct of activities under this section. Below are the associations of the Board of Governors that upon appointment by the Comptroller General, fit within PPACAs definition of a conflict of interest.. Notes: ...
CONTACT:. Lorie Slass (215) 801-4057. [email protected] FOR IMMEDIATE RELEASE August 30, 2017 Society to Improve Diagnosis in Medicine Approved for a $250,000 Engagement Award from the Patient-Centered Outcomes Research Institute Award Will Address Gap in Patient Representation in Development of Research Around Diagnostic Error and Establish a New Academy of Patient Partners. (August 30, 2017) The Society to Improve Diagnosis in Medicine (SIDM) has received a Eugene Washington PCORI Engagement Award from the Patient-Centered Outcomes Research Institute (PCORI). The 18-month project, Patients Improving Research in Diagnosis, will develop and evaluate an innovative curriculum to train Patient Partners to participate in the design, execution and dissemination of research to improve diagnosis. SIDM and its partners from Project Patient Care (PPC) and the MedStar Institute for Quality and Safety will also work together to develop a new Academy for Patient Partners. The 2015 National ...
Official website for the American Nurses Association, part of the ANA Enterprise, featuring nursing news, professional development and continuing education for nurses.
Dr. Gelfands research focuses on observational epidemiology in psoriasis and clinical trials in dermatologic diseases such as psoriasis, atopic dermatitis, cutaneous T cell lymphoma and acne/hidradenitis. Particular areas of interest include use of large medical records databases for epidemiologic and pharmacoepidemiologic studies in skin diseases and the design of efficient phase II trials for new indications of existing drugs and alternative medicines for the treatment of skin disease. Current, large ongoing projects include a prospective population-based cohort study of 8,000 psoriasis patients to evaluate cardiovascular risk and the development of the Dermatology Clinical Effectiveness Research Network (DCERN) to conduct comparative effectiveness studies in psoriasis and other dermatological diseases (www.dermcern.org ...
One of PCORIs goals is to improve the methods that researchers use for patient-centered outcomes research. PCORI funds methods projects like this one to better understand and advance the use of research methods that improve the strength and quality of comparative effectiveness research. This research project is in progress. PCORI will post the research findings on this page within 90 days after the results are final.
A UC Irvine infectious disease specialist has received a three-year, $10 million grant to explore the effectiveness of new methods to prevent staph infections in people who harbor MRSA bacteria when theyre discharged from the hospital.. The federal Agency for Healthcare Research & Quality awarded the grant as part of its CHOICE program, which is funded by American Recovery & Reinvestment Act of 2009. CHOICE grants will support large projects in comparative effectiveness research to aid decision making in priority areas of clinical care. Selected studies are deemed likely to result in major healthcare advances.. The UC Irvine study, led by Dr. Susan Huang-medical director of epidemiology & infection prevention at UC Irvine Medical Center and a UC Irvine Health Policy Research Institute affiliate-may provide the first post-discharge preventative treatments for the 1.8 million Americans each year who carry the methicillin-resistant Staphylococcus aureus bacteria.. MRSA is highly contagious and ...
Dr. Goodman is a Senior Vice President at The Lewin Group, a health care policy consulting firm based in Falls, Church, Virginia. Dr. Goodman has 30 years of experience in such areas as health technology assessment (HTA), evidence-based health care, comparative effectiveness research, health economics, and studies pertaining to health care innovation, regulation, and payment. He directs studies and projects for an international range of government agencies; pharmaceutical, biotechnology, and medical device companies; health care provider institutions; and professional, industry, and patient advocacy groups. His recent work has involved such areas as oncology, cardiovascular disease, diabetes, blood disorders, obesity, end-stage renal disease, HIV/AIDS, follow-on biologics, diagnostic testing, pharmacogenomics, personalized medicine, and organ donation and transplantation. Dr. Goodman is an internationally recognized health policy issues moderator and facilitator of expert panels, health industry ...
Dr. Robert (Robin) Hines is a cancer epidemiologist and cancer health services researcher. He received his Ph.D. in Epidemiology from the University of Alabama at Birmingham Ryals School of Public Health in 2009. The themes of Dr. Hines research concern improving the quality of cancer care and investigating trends and causes of disparities in cancer outcomes. Dr. Hines has conducted large scale epidemiologic studies to quantify and explain causes of disparate cancer outcomes for various segments of the population defined by race-ethnicity, socioeconomic status, geography, and age. He has also conducted observational comparative effectiveness research designed to provide evidence of treatment effectiveness when the data from randomized controlled trials was either nonexistent or equivocal. Overall, the goal of Dr. Hines research is to improve patient-centered, clinical, and population-level cancer outcomes. Dr. Hines research has been funded by the National Institutes of Health, the Florida ...
Topic: Update in the Care and Treatment of Patients Suffering Out of Hospital Cardiac Arrest. Speaker: Frederic S Resnic, MD MSc FACC FSCAI, Chairman, Department of Cardiovascular Medicine, The Landsman Cardiovascular Center; Co-Director, Comparative Effectiveness Research Institute, Sidney Alexander MD Chair in Cardiovascular Medicine, Lahey Hospital and Medical Center; Associate Professor of Medicine, Tufts University School of Medicine. Date/Time: 8am to 9am on Thursday 4 May 2017. Location: 1st Floor Conference Room, General Wing, KEMH. Notes:. A minimum of 50 minutes is required for CME participation. Non-physician professionals who wish to participate in the Physicians CME are urged to RSVP to 239-5918 as space is limited.. Through an agreement between the Royal College of Physicians and Surgeons of Canada and the American Medical Association, physicians may convert Royal College MOC credits to AMA PRA Category 1 Credits™. Information on the process to convert Royal College MOC credit to ...
Purpose. This was a Data Capacity-Building Project, to build a robust comparative effectiveness research infrastructure, agenda, and collaborative partnerships focused on eliminating health disparities. Specifically, a database was built comprised of all Medicaid enrollees and claims in the states that share in common both adverse minority health outcomes and the historical roots of racial health disparities in the South. Setting and Participants. A 100 percent sample of four years 2004-2007 of Medicaid Analytic Extract (MAX-file) data (plus Medicare-linked claims for dual-eligibles) from fourteen southern states, representing 3.8 to 5.4 million persons each year (one-third of all United States Medicaid enrollees, nearly half [48 percent] of African American and 21 percent of Latino Medicaid enrollees in the United States) was obtained from the Centers for Medicare and Medicaid Services (CMS). This region is the epicenter of the Black-White health disparities epidemic, and has also experienced a ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: ARRAOS: Recovery Act Limited Competition: Behavioral Economics for Nudging the Implementation of Comparative Effectiveness Research: Pilot Research (RC4) RFA-OD-10-002. NIA
Dr. Ilowite serves as chair of the Childhood Arthritis & Rheumatology Research Alliance, a clinical research network that performs investigator-initiated studies in pediatric rheumatic diseases. He is principal investigator on a number of NIH-sponsored projects, including studies of the use of interleukin-1 in juvenile idiopathic arthritis and comparative effectiveness research in pediatric rheumatic diseases. He is a recipient of the Lewis M. Fraad Award for Excellence in Resident Teaching at Montefiore and past chairman of the Sub-Board of Rheumatology of the American Board of Pediatrics. ...
Comparative Effectiveness Research (CER): defined by the Institute of Medicine (IOM) as the study of methods to prevent, diagnose, treat, and monitor a clinical condition or to improve the delivery of care. In reform, CER is considered an important evidence-generating tool quality and contain costs. Will be administered by an independent entity called PCORI. See Clinical Pathways and PCORI ...
The goal of our research program is to develop approaches to prevent and treat kidney disease and its complications. Chronic kidney disease (CKD) currently affects ~13% of the US population and is influenced by the growing epidemics of diabetes mellitus (DM) and obesity. Our program specifically focuses on new targets for CKD prevention to limit the rising tide in the US and globally; and outcome studies among patients with all stages of CKD to improve cardiovascular outcomes, mortality, and quality of life.. Comparative effectiveness studies of mineral metabolism treatment strategies in end stage kidney disease. In this mixed quantitative and qualitative program of study, we use electronic health record data from a large national dialysis provider linked to USRDS administrative claims, and focused interviews with patients and providers, to understand the optimal approaches for managing hyperphosphatemia and secondary hyperparathyroidism in patients with ESKD. Our ultimate goal is to design and ...
Neurosurgical biopsies and orthopaedic joint replacement were the first procedures to use robotic assistance. The first robotic cholecystectomy was performed nearly 20 years ago, and since then, robotic surgery has been increasingly widespread. Published data from the Nationwide Inpatient Sample show an increase from 2008 to 2009 in the proportion of prostatectomies, nephrectomies, hysterectomies, coronary artery bypasses, and gastrectomies performed robotically.23 Most prostatectomies and one-third of partial nephrectomies were performed robotically in 2009. Hysterectomy was the second most common (18 percent of total) robotic procedure performed in U.S. hospitals during the period of time examined. A more recent study estimates that 90 percent of prostatectomies and 20 percent of hysterectomies in the U.S. are conducted robotically.24 The diffusion of robotic prostatectomy occurred in the early 2000s, despite the lack of large comparative effectiveness studies (which first appeared in 2009), ...
This article describes the development of the Claudication Symptom Instrument (CSI) and its measurement properties for evaluating the symptom experience of patients diagnosed with intermittent claudication (IC). We conducted semi-structured qualitative interviews with IC patients for item development and cognitive interviews in which patient comprehension of items was tested. We evaluated measurement properties using data collected and analyzed in the context of an observational comparative effectiveness study of IC treatments. Items measuring five symptom important to patients were developed and cognitively tested: Pain, Numbness, Heaviness, Cramping, and Tingling. Item means (higher means worse) ranged from 1.1 (Tingling) to 2.3 (Pain) (range: 0 none to 4 extreme). Rasch analysis yielded support for an overall score (χ
TY - JOUR. T1 - Chronic lateral epicondylitis. T2 - Comparative effectiveness of a home exercise program including stretching alone versus stretching supplemented with eccentric or concentric strengthening. AU - Martinez-Silvestrini, Julio A.. AU - Newcomer, Karen L.. AU - Gay, Ralph. AU - Schaefer, Michael P.. AU - Kortebein, Patrick. AU - Arendt, Katherine W.. PY - 2005/10/1. Y1 - 2005/10/1. N2 - The objective of this study was to evaluate the effectiveness of eccentric strengthening. Ninety-four subjects (50 men) with chronic lateral epicondylitis were allocated randomly into three groups: stretching, concentric strengthening with stretching, and eccentric strengthening with stretching. Subjects performed an exercise program for six weeks. All three groups received instruction on icing, stretching, and avoidance of aggravating activities. The strengthening groups received instruction on isolated concentric and eccentric wrist extensor strengthening, respectively. At six weeks, significant ...
TY - JOUR. T1 - Response to letter regarding article, comparative effectiveness of carotid revascularization therapies. T2 - Evidence from a national hospital discharge database. AU - McDonald, Robert J.. AU - McDonald, Jennifer S.. AU - Cloft, Harry J.. N1 - Copyright: Copyright 2016 Elsevier B.V., All rights reserved.. PY - 2015/2/6. Y1 - 2015/2/6. UR - http://www.scopus.com/inward/record.url?scp=84922335512&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84922335512&partnerID=8YFLogxK. U2 - 10.1161/STROKEAHA.114.007861. DO - 10.1161/STROKEAHA.114.007861. M3 - Letter. C2 - 25550376. AN - SCOPUS:84922335512. VL - 46. SP - e42. JO - Stroke. JF - Stroke. SN - 0039-2499. IS - 2. ER - ...
Comparative Effectiveness of Adjustable Lordotic Expandable versus Static Lateral Lumbar Interbody Fusion Devices: One Year Clinical and Radiographic Outcomes
implementing their i2b2 (Informatics for Integrating Biology and the Bedside) systems and SHRINE (Shared Health Research Information Network) systems.. Omar Aldaoud, DCC Associate Director and Director of Information Security and Technology Integration, will serve as DCC project lead. We are pleased to be a part of this consortium of stellar research institutions and look forward to bringing the technological expertise available through RCMI CC to the table.. This effort has been made possible by the Patient Affordable Care Act, Dr. Mandl stated, This is a pivotal moment in healthcare, made possible by the Patient Affordable Care Act, allowing us to cross institutional boundaries and join together as patients, clinicians, advocates, leaders, and researchers to conceive and advance new models of clinical research.. The Patient-Centered Outcomes Research Institute (PCORI) awarded more than $90 million to support 29 clinical research data networks that will form a national Patient-Centered ...
TY - JOUR. T1 - Cost of Unnecessary Amylase and Lipase Testing at Multiple Academic Health Systems. AU - Ritter, Jacob P.. AU - Ghirimoldi, Federico M.. AU - Manuel, Laura S.M.. AU - Moffett, Eric E.. AU - Novicki, Thomas J.. AU - McClay, James C.. AU - Shireman, Paula K.. AU - Brimhall, Bradley B.. N1 - Funding Information: Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This work was supported in part by the National Center for Advancing Translational Sciences, National Institutes of Health (grant numbers UL1 TR001120, UL1 TR002645, and U01 TR002393); and the Patient-Centered Outcomes Research Institute (grant number CDRN-1306-04631 pilot project grant funding to the Greater Plains Collaborative). Publisher Copyright: © 2019 American Society for Clinical Pathology, 2019. All rights reserved. For permissions, please e-mail: [email protected] PY - 2020/2/8. Y1 - 2020/2/8. N2 - Objectives: To ...
Arbor Research Collaborative for Health and the NephCure Foundation have been approved for a funding award by the Patient-Centered Outcomes Research Institute to develop and expand a health data network that will be part of PCORnet: the National Patient-Centered Clinical Research Network. This new network, the NephCure Kidney Network, is one of 29 research networks that were approved for a total of $93.5 million from PCORI to form this new national resource that aims to boost the efficiency of health research.. (AAKP launches nutrition tracker) Experts from Arbor Research will collaborate with researchers from the NephCure Foundation (NephCure) and the University of Michigan, specializing in adult and pediatric clinical nephrology, clinical research in nephrotic syndrome, epidemiology, patient advocacy, and data management. This team will develop the NephCure Kidney Network as a patient-powered research network. This new network will enable important clinical and patient-reported data on ...
Historical luminaries such as Hippocrates and Osler exhorted physicians to place the patients interests above their own, and to consider patient values for medical decision-making. Nevertheless, only in recent decades has the medical profession begun to shift from a paternalistic doctor knows best stance towards one explicitly endorsing patient-centered, evidence-based, [50-52] shared decision-making [53-55]. The growing strength of patient-orientated shared decision-making in the U.S. is exemplified by the focus on patient-centered medical homes, [56, 57] the emphasis on patient-oriented evidence that matters (POEMs), [58-60] and the Patient-Centered Outcomes Research Institute (PCORI) [61]. In the U.K., the importance of patient-oriented decision-making is highlighted in the Equity and Excellence NHS white paper and in the National Health Service Constitution [62, 63]. Following these directives, the NICE lipid guidelines state, Treatment and care should take into account individual needs ...
Washington, DC) -The Patient-Centered Outcomes Research Institute (PCORI®), selected AcademyHealth in partnership with the Patient Advocate Foundation, to serve as the Engagement Coordinating Center (ECC) for PCORnet®, the National Patient-Centered Clinical Research Network, with the goal of increasing the capacity of patients, caregivers and community members to participate in and inform the nations clinical research.. The meaningful engagement of patients, caregivers, and community members in research undertaken through PCORnet is vital to ensuring these initiatives are focused on improving outcomes most important to patients. ECC activities will focus on facilitating collaborations and information sharing across the clinical research networks of PCORnet, and amplify promising engagement practices within PCORnet® Network Partners. The lead organizations, AcademyHealth and the Patient Advocate Foundation, were selected by PCORnet Network Partners based on their expertise in engagement, ...
Marc M. Boutin, JD, is the chief executive officer of the National Health Council. He has been a leading voice for greater patient involvement at every stage of the healthcare continuum. Currently he serves as a member of the Patient-Centered Outcomes Research Institute Patient Engagement Advisory Panel, FasterCures Benefit-Risk Advisory Council, and MDIC Patient-Centered Benefit-Risk Steering Committee. He is a founding member of the international Patient-Focused Medicine Development consortium and has served on the Governing Board of the International Alliance of Patients Organizations as a member and treasurer ...
Quite often those decisions are surgical and often irreversible. Former patients and health care advocates have long complained that parents are provided inadequate information to make decisions for their child with a disorder of sex development.. But with a new award from the Patient-Centered Outcomes Research Institute (PCORI), researchers at the University of Michigan hope to provide parents with the tools needed to make decisions about disorders of sex development (DSD).. When a child with a disorder of sex development is born, parents are often experiencing enormous distress, says David E. Sandberg, Ph.D., director of the Division of Child Behavioral Health at C.S. Mott Childrens Hospital and professor of pediatrics and communicable diseases at the University of Michigan Medical School.. The right decisions about gender assignment - is it a boy or a girl - and the best course of action (for example should there be surgery? what kind? when?) are not obvious.. Parents can make decisions ...
Marshall L. Summar, MD, Division Chief, Genetics and Metabolism at Children’s National Health System, has been appointed chair of the Patient-Centered Outcome Research Institute’s (PCORI) new Advisory Panel on Rare Disease by PCORI’s Board of Governors.
Earlier this month the Center for Public Integrity (CPI) published a sharp-edged piece on PCORI-the Patient-Centered Outcomes Research Institute. The piece raised some salient issues and its timely to take stock of PCORI at the half way point of its authorized funding. (Unless renewed, PCORI sunsets in 2019.) The Affordable Care Act created PCORI as an independent nonprofit (non-government) entity. But PCORIs funding and structure makes it more or less quasi-government. It gets its money from the Medicare trust fund, treasury general funds, and a tax on private insurers and self-funded insurance plans ($2.08 per covered life). PCORI launched in late 2010 and began funding research in earnest until 2013. The main focus of that research, mandated by Congress, is to compare treatments in a way that results in meaningful results for doctors and patients as they make clinical decisions. No small task. The CPI piece probes the emerging debate about how PCORI is being operated and spending its ...
The risk of acute thrombotic events such as venous thromboembolism (VTE) and ischemic stroke in transgender women receiving hormone therapy was addressed in our longitudinal Study of Transition, Outcomes & Gender (STRONG), supported by the Patient-Centered Outcomes Research Institute. STRONG is a cohort of transgender people enrolled in Kaiser Permanentes Georgia, Northern California, and Southern California regions. This project found increased risk of VTE and ischemic stroke among transwomen treated with estrogen; however, the development of practical recommendations for the management of transwomen will require a more formal pharmacoepidemiologic analysis evaluating comparative risks of different hormone formulations, routes of administration, and doses. These data are available, but the definitive analyses were not possible due to sparse treatment-specific strata. To address these limitations, with this supplement we will include additional subjects identified at existing STRONG sites ...
Marshall L. Summar, MD, Division Chief, Genetics and Metabolism, at Children’s National has been appointed to the Patient-Centered Outcome Research Institute (PCORI)’s inaugural Advisory Panel on Rare Disease.
Purpose: : To report the two-year incidence of IOP elevations and glaucomatous optic nerve damage in patients with uveitis randomized to either FA implants or systemic therapy. Methods: : The MUST Trial is a randomized (allocation ratio 1:1), partially masked, parallel treatment comparative effectiveness trial in which patients were randomized to either FA implants or systemic therapy. Patients 13 years of age or older who had non-infectious intermediate, posterior or panuveitis in one or both eyes active within the prior 60 days for which systemic corticosteroids were indicated were eligible. Visual fields were obtained at baseline and every twelve months using the Humphrey 24-2 SITA-fast protocol and were repeated if they were unreliable or abnormal at baseline. Optic nerve photos were taken in stereo at a nominal 30 or 35 degree angle depending on the fundus camera used at baseline and at three, six, and twelve month follow-up visits and annually thereafter. Glaucoma was diagnosed on the ...
TY - JOUR. T1 - Hypertension Self-management in Socially Disadvantaged African Americans. T2 - the Achieving Blood Pressure Control Together (ACT) Randomized Comparative Effectiveness Trial. AU - Boulware, L. Ebony. AU - Ephraim, Patti L.. AU - Hill-Briggs, Felicia. AU - Roter, Debra L.. AU - Bone, Lee R.. AU - Wolff, Jennifer L.. AU - Lewis-Boyer, La Pricia. AU - Levine, David M.. AU - Greer, Raquel C.. AU - Crews, Deidra C.. AU - Gudzune, Kimberly A.. AU - Albert, Michael C.. AU - Ramamurthi, Hema C.. AU - Ameling, Jessica M.. AU - Davenport, Clemontina A.. AU - Lee, Hui Jie. AU - Pendergast, Jane F.. AU - Wang, Nae Yuh. AU - Carson, Kathryn A.. AU - Sneed, Valerie. AU - Gayles, Debra J.. AU - Flynn, Sarah J.. AU - Monroe, Dwyan. AU - Hickman, Debra. AU - Purnell, Leon. AU - Simmons, Michelle. AU - Fisher, Annette. AU - DePasquale, Nicole. AU - Charleston, Jeanne. AU - Aboutamar, Hanan J.. AU - Cabacungan, Ashley N.. AU - Cooper, Lisa A.. N1 - Publisher Copyright: © 2019, Society of General ...
Dr. Yu is the director of genitourinary cancers radiotherapy and co-director of the gamma knife program for the department of Therapeutic Radiology at the Yale School of Medicine. As a former Yale Center for Clinical Investigation scholar and member of the Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center at Yale, Dr. Yus research centers on the comparative effectiveness of new radiation technologies and how these new technologies are adopted nationally. Dr. Yu is currently a Senior Editor of the journal Practical Radiation Oncology, and is on the editorial boards of the Journal of Clinical Oncology, Journal of Clinical Oncology - Clinical Cancer Informatics, Journal of Surgical Oncology, and Oncology (Williston Park). ...
This report summarizes the available evidence on the comparative efficacy, effectiveness, and harms of 12 second-generation antidepressants: bupropion, citalopram, duloxetine, escitalopram, fluoxetine, fluvoxamine, mirtazapine, nefazodone, paroxetine, sertraline, trazodone, and venlafaxine in treating patients with MDD, dysthymia, and subsyndromal depression. It also evaluates the comparative efficacy and effectiveness for maintaining remission and for treating accompanying symptoms such as anxiety, insomnia, or neurovegetative symptoms.
The International Society for Pharmacoeconomics and Outcomes Research (ISPOR) and the International Society for Pharmacoepidemiology (ISPE) created a task force to make recommendations regarding good procedural practices that would enhance decision makers confidence in evidence derived from RWD studies. Peer review by ISPOR/ISPE members and task force participants provided a consensus-building iterative process for the topics and framing of recommendations ...
I am a clinical cardiac electrophysiologist, and I study the comparative effectiveness, cost-effectiveness and clinical outcomes associated with cardiac arrhythmias and their treatments. , cardiac electrophysiology and exercise physiology. I have an NIH funded career development award (K23) to study the comparative effectiveness of ablation for atrial fibrillation compared with medical therapy for the prevention of long term adverse outcomes such as death and ischemic stroke. I am also conducting research sponsored by the American Heart Association and industry focused on ICD therapy, heart failure, and atrial fibrillation.. Specialized Terms: Arrhythmias; atrial fibrillation; atrial flutter; ventricular tachycardia; ventricular fibrillation; implantable cardioverter-defibrillator; cardiac ablation; outcomes research; cost- ...
Rheumatoid arthritis (RA) is a chronic debilitating disease characterized by progressive joint damage, reduced quality of life, loss of productivity and premature death. It affects 1% of the adult US population, and is one of the most demanding diseases on our healthcare resources. Biologic disease modifiers are new drugs that provide hope to improve the course of RA; however, biologics are among the most expensive specialty drugs. Although the treatment costs of RA have recently increased with the introduction of biologics, most of the economic and societal impacts are due to consequences of RA rather than direct treatment costs. Thus, the cost-effectiveness of biologics in RA is of high priority as recognized by many agencies including the National Institute of Health. This thesis focuses on three limitations of the current cost-effectiveness analyses (CEA) of biologics in RA. First, Most CEAs are based on randomized clinical trials (RCT) that are rarely applicable to real-life clinical ...
Comparative Study; Journal Article; Meta-Analysis; Research Support, Non-U.S. Govt; Review; Blood Transfusion, Autologous; Botulinum Toxins; Glucocorticoids; Humans; Hyaluronic Acid; Platelet-Rich Plasma; Polyethylene Glycols; Randomized Controlled Trials as Topic; Sclerosing Solutions; Tennis Elbow; Viscosupplements ...
Background: High rates of adverse birth outcomes persist in the United States despite increased access to individual prenatal care (IPNC). Psychosocial factors influence birth outcomes and affect infant and child development and maternal functioning. Group prenatal care (GPNC) combines individual physical assessments and facilitated group education and support. Studies of GPNC show promising results, including lowered preterm birth rates, but the GPNC psychosocial mechanisms influencing birth outcomes are unclear. Methods: Surveys at study enrollment (N=248), late pregnancy, and six weeks postpartum assessed psychosocial effects of each PNC model. Multiple regression models and planned moderator analyses tested whether GPNC participants had better outcomes compared to IPNC, as main effects and for at-risk subgroups. Frequent, brief semi-structured interviews with 29 women during pregnancy through six weeks postpartum were conducted and analyzed to describe important PNC functions and how experiences and
OBJECTIVE To compare three continuous glucose monitoring (CGM) devices in subjects with type 1 diabetes under closed-loop blood glucose (BG) control. RESEARCH DESIGN AND METHODS Six subjects with type 1 diabetes (age 52 ± 14 years, diabetes duration 32 ± 14 years) each participated in two 51-h closed-loop BG control experiments in the hospital. Venous plasma glucose (PG) measurements (GlucoScout, International Biomedical) obtained every 15 min (2,360 values) were paired in time with corresponding CGM glucose (CGMG) measurements obtained from three CGM devices, the Navigator (Abbott Diabetes Care), the Seven Plus (DexCom), and the Guardian (Medtronic), worn simultaneously by each subject. Errors in paired PG-CGMG measurements and data reporting percentages were obtained for each CGM device. RESULTS The Navigator had the best overall accuracy, with an aggregate mean absolute relative difference (MARD) of all paired points of 11.8 ± 11.1% and an average MARD across all 12 experiments of 11.8 ± ...
Ninety-six samples from hepatitis B virus (HBV)-infected individuals were used to compare ViveST samples to frozen samples in COBAS TaqMan, RealArt, and VERSANT. Correlation (r) between ViveST samples and frozen samples was 0.99 in all three platforms. Correlations among tests using frozen samples were 0.96 for COBAS and RealArt, 0.94 for COBAS and VERSANT, and 0.97 for VERSANT and RealArt. The results indicate that ViveST may be useful in clinical practice. Different HBV-VL platforms correlated well with one another. ...
Our analyses show the renoprotective effects and superiority of using ACE inhibitors in patients with diabetes, and available evidence is not able to show a better effect for ARBs compared with ACE inhibitors. Considering the cost of drugs, our findings support the use of ACE inhibitors as the first …
The proportion of the elderly people (e65 years) has continued to increase among over half a million Americans with end-stage renal disease (ESRD). In 1990, 200...
The Gelfand Clinical Research Lab designs and conducts clinic-based and population-based observational studies and interventional and translational clinical trials in common and rare skin diseases. Gelfand and his team focus on pharmacoepidemiology, patient centered outcomes and effectiveness research, psychometrics and instrument/diagnostic test development, and human translational studies aimed at development of novel treatment approaches and further understanding disease pathogenesis. A major goal of the Gelfands research program is improving psoriasis patient outcomes in the skin and joints, while lowering the risk of diabetes, cardiovascular disease and mortality.
Cancer Outcomes, Public Policy, and Effectiveness Research Center, Yale Cancer Center and Yale University School of Medicine, New Haven, CT, USA; Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA ...
There were some reported deaths in people taking Bactrium, who were also hypertensives on ACE-I. So the Canadian Researches looked into this issue. This resulted in a paper published in the BMJ 30th Oct issue. The paper is entitled, Co-trimoxazole and sudden cardiac deaths in patients taking inhibitors of Renin Angiotensin system.. The study was led by Dr Michael Fralich From the Canadian Drug Safety and Effectiveness Research Center. They review the hospitalisation data and discharged data of the Ontario Health District from 1st April 1994 till 1st Jan 2012. There were all together 39,879 sudden cardiac deaths. They analysed those who had received ACEI / ARB and also antibiotics Co-trimoxazole and also ciprofloxacin and two other antibiotics. These SCD were matched against 3,733 patients of the same age and sex group and who also have the same co-morbid factors of T2DM and kidney disease. These were used as matched controls ...
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This article is from a peer-reviewed journal article on Sawtooth Softwares ACBC (Adaptive CBC) approach. Indeed, most ACBC research has been published at the Sawtooth Software and joint SKIM/Sawtooth Software conferences, which arent subject to a formal academic review process. Were pleased to point you to an article recently published in a peer-reviewed healthcare economics journal entitled The Patient: Patient-Centered Outcomes Research.. The article is authored by Charles E. Cunningham, Ken Deal, and Yvonne Chen.. The authors review previous ACBC studies involving consumer electronics, home purchases, PCs, automobiles, fast food, mobile telephone, chemical products, and consumer durables. They conclude:. A review of randomized trials and cross-over studies suggests that, although ACBC surveys require more time than conventional approaches to CA, informants find ACBC surveys more engaging. In most studies, ACBC surveys yield lower standard errors, improved prediction of hold-out task ...
TY - JOUR. T1 - Application of a Risk Score to Identify Older Adults with Community-Onset Pneumonia Most Likely to Benefit From Empiric Pseudomonas Therapy. AU - Frei, Christopher R.. AU - Rehani, Sylvie. AU - Lee, Grace C.. AU - Boyd, Natalie K.. AU - Attia, Erene. AU - Pechal, Ashley. AU - Britt, Rachel S.. AU - Mortensen, Eric M.. N1 - Funding Information: Dr. Mortensen was supported in part by the University of Texas Southwestern Center for Patient-Centered Outcomes Research. This material is the result of work supported with resources and the use of facilities at the South Texas Veterans Health Care System. The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs or the National Institutes of Health.. PY - 2017/2/1. Y1 - 2017/2/1. N2 - Study Objective: To assess the impact of empiric Pseudomonas pharmacotherapy on 30-day mortality in hospitalized patients with community-onset pneumonia stratified according ...
My research is focused on development and application of novel statistical methods in genetic epidemiology, anesthesiology, patient-centered outcomes research
This paper presents a protocol for a randomised controlled trial of the Cardiac-Diabetes Transcare program which is a transitional care, multi-modal self-management program for patients with acute coronary syndrome comorbid with type 2 diabetes. Prior research has indicated people hospitalised with dual cardiac and diabetes diagnoses are at an elevated risk of hospital readmissions, morbidity and mortality. The primary aim of this study is to evaluate the effectiveness (and cost-effectiveness) of a Cardiac-Diabetes Transcare intervention program on 6-month readmission rate in comparison to usual care. A two-armed, randomised controlled trial with blinded outcome assessment will be conducted to evaluate the comparative effectiveness of two modes of care, including a Usual Care Group and a Cardiac-Diabetes Transcare Intervention (in addition to usual care) Group. The primary outcome is 6-month readmission rate, although a range of secondary outcomes will be collected (including self-efficacy) at baseline,
... as well as a certificate in comparative effectiveness research.[27] Interdisciplinary Biomedical Science Graduate Program[edit] ... comparative effectiveness research; immunology and immunological approaches to cancer; and cancer virology. The school is also ... and comparative effectiveness research. An innovative system of Web-based learning portfolios facilitates learner-mentor ... Research[edit]. The University of Pittsburgh School of Medicine is a leading center for medical research. Of the medical ...
Comparative Effectiveness Review No. 123. AHRQ Publication No. 13-EHC113-EF. Rockville, MD: Agency for Healthcare Research and ... Many issues should be considered related to their comparative effectiveness, including the cost of DOACs, risk of stroke, risk ... "BMJ (Clinical Research Ed.). 348: g2116. doi:10.1136/bmj.g2116. PMC 4688652. PMID 24733535.. ... "BMJ (Clinical Research Ed.). 532: h7013. doi:10.1136/bmj.h7013. PMC 5482349. PMID 26786546.. ...
Medication Adherence Interventions: Comparative Effectiveness. Closing the Quality Gap: Revisiting the State of the Science. ... Office of Behavior and Social Sciences Research. "Adherence Research Network". U.S. National Institutes of Health. Archived ... US NIH Office of Behavior and Social Sciences Research (2008). "Framework for adherence research and translation: a blueprint ... Rockville, MD: Agency for Healthcare Research and Quality. September 2012. *^ a b Rifaat Nizar; Abdel-Hady Elham; Hasan Ali A ( ...
"Comparative Effectiveness Reviews (92). Rockville, MD: US Agency for Healthcare Quality and Research. PMID 23658937. Archived ... Agency for Healthcare Research and Quality (US). PMID 23658936.. *^ Feldner MT, Monson CM, Friedman MJ (January 2007). "A ... Journal of Rehabilitation Research and Development. 49 (5): 703-15. doi:10.1682/JRRD.2011.09.0183. PMID 23015581. Archived (PDF ... Progress in Brain Research. 167. pp. 287-91. doi:10.1016/S0079-6123(07)67025-3. ISBN 978-0-444-53140-7. . PMID 18037027.. ...
"Consumer involvement in systematic reviews of comparative effectiveness research". Health Expect. 16 (4): 323-337. doi:10.1111/ ... health professional organizations can request consumer representatives for their research/research implementation projects and ... Reinventing medical research (1st ed.). Durham, NC: Duke University Press Books. ISBN 978-0822318163.. ... Diana Zuckerman (President of the National Center for Health Research and The Cancer Prevention and Treatment Fund) ...
AHRQ Comparative Effectiveness Reviews.: vi, 1. PMID 27148613.. *^ a b c d Nelson RL, Suda KJ, Evans CT (March 2017). " ... Research[edit]. *As of 2019, vaccine candidates providing immunity against C. difficile toxin A and C. difficile toxin B have ... "Comparative effectiveness of Clostridium difficile treatments: a systematic review". Annals of Internal Medicine. 155 (12): 839 ... Research has studied whether the appendix has any importance in C. difficile. The appendix is thought to have a function of ...
"Comparative Effectiveness Reviews (92). Rockville, MD: US Agency for Healthcare Quality and Research. PMID 23658937. Archived ... Agency for Healthcare Research and Quality (US). PMID 23658936.. *^ Feldner MT, Monson CM, Friedman MJ (January 2007). "A ... Progress in Brain Research. 167. pp. 287-91. doi:10.1016/S0079-6123(07)67025-3. ISBN 978-0-444-53140-7. . PMID 18037027.. ... Progress in Brain Research. 167. pp. 151-69. doi:10.1016/S0079-6123(07)67011-3. ISBN 9780444531407. . PMID 18037013.. ...
Comparative Effectiveness Reviews. Rockville, MD: Agency for Healthcare Research and Quality. Byatt N, Deligiannidis KM, ... An Update of the 2007 Comparative Effectiveness Review (Report). ... to evaluate all the research available prior to 2004. The group ...
An Update of the 2006 Comparative Effectiveness Review". Comparative Effectiveness Reviews. 38. Agency for Healthcare Research ... The effectiveness of glucosamine is controversial. Reviews have found it to be equal to or slightly better than placebo. A ... The effectiveness of injections of platelet-rich plasma is unclear; there are suggestions that such injections improve function ... Further research is needed to determine if balnotherapy for osteoarthritis (mineral baths or spa treatments) improves a ...
Comparative Effectiveness Reviews. Rockville: Agency for Healthcare Research and Quality. PMID 22091473.[page needed] Rovati LC ... An Update of the 2006 Comparative Effectiveness Review [Internet]". Agency for Healthcare Research and Quality (US). PMID ... The Osteoarthritis Research Society International recommends that glucosamine be discontinued if no effect is observed after ... Critical review of research evaluating glucosamine-based nutraceuticals for treatment of joint pain and degenerative joint ...
An Update" (PDF). Comparative Effectiveness Review. number 27 (AHRQ Pub. No. 11-EHC038-1). Archived from the original (PDF) on ... Research, Center for Drug Evaluation and. "Drug Safety and Availability - Sodium-glucose Cotransporter-2 (SGLT2) Inhibitors". ... "Comparative effectiveness and safety of medications for type 2 diabetes: An update including new drugs and 2-drug combinations ... "The Oral Diabetes Drugs Treating Type 2 Diabetes Comparing Effectiveness, Safety, and Price" (PDF). Archived (PDF) from the ...
AHRQ Comparative Effectiveness Reviews. Agency for Healthcare Research and Quality (US). PMID 26844312. Eschler DC, Klein PA ( ... Sustained effectiveness without apparent tolerance was demonstrated in clinical studies of up to 12 weeks duration. This ... Based on in vitro research, the major enzymes involved in the metabolism of doxepin are the cytochrome P450 enzymes CYP2D6 and ... The H1 receptor antagonism of doxepin is responsible for its hypnotic effects and its effectiveness in the treatment of ...
AHRQ Comparative Effectiveness Reviews. Rockville (MD): Agency for Healthcare Research and Quality (US). PMID 26866209. Motzer ... "Kidney cancer statistics". Cancer Research UK. Retrieved 27 October 2014.. ...
AHRQ Comparative Effectiveness Reviews. Rockville (MD): Agency for Healthcare Research and Quality (US). PMID 26844312. Conn DK ... AHRQ Comparative Effectiveness Reviews. Rockville (MD): Agency for Healthcare Research and Quality (US). PMID 22132426. ... Mitchell MD, Gehrman P, Perlis M, Umscheid CA (May 2012). "Comparative effectiveness of cognitive behavioral therapy for ... The effectiveness and safety of alternative medicine is unclear. Between 10% and 30% of adults have insomnia at any given point ...
Diagnosis and Comparative Effectiveness". AHRQ Comparative Effectiveness Reviews. Agency for Healthcare Research and Quality ( ... Research projects that assess the efficacy of anti-incontinence therapies often quantify the extent of urinary incontinence. ... The effectiveness of different therapeutic approaches to treating urinary incontinence is not well studied for some medical ... Wang W, Huang QM, Liu FP, Mao QQ (December 2014). "Effectiveness of preoperative pelvic floor muscle training for urinary ...
AHRQ Comparative Effectiveness Reviews. Rockville (MD): Agency for Healthcare Research and Quality (US). PMID 26985522. van ... Seco J, Kovacs FM, Urrutia G (October 2011). "The efficacy, safety, effectiveness, and cost-effectiveness of ultrasound and ... Lumbar traction lacks effectiveness as an intervention for radicular low back pain. It is also unclear whether lumbar supports ... There has been little research that supports the use of lumbar extension machines and thus they are not recommended. There is ...
AHRQ Comparative Effectiveness Reviews. Rockville (MD): Agency for Healthcare Research and Quality (US). OCLC 845095216. PMID ... The decision to use or not use each form may be based upon therapist preference, patient preference or effectiveness for ... There is a great emphasis on using clinical research and prior clinical knowledge in determining how to move forward with ... The use of different therapeutic approaches will be based on the effectiveness in resolving the patient's problems, rather than ...
AHRQ Comparative Effectiveness Review. Rockville (MD): Agency for Healthcare Research and Quality (US). doi:10.23970/ ... Initial research on MDMA-assisted psychotherapy has shown the treatment to be efficacious and well tolerated. For example, in a ... While it is not yet accepted medical treatment, there are often studies being done to test its effectiveness. Usually, it is ... "Long-term Nabilone Use: A Review of the Clinical Effectiveness and Safety". CADTH Rapid Response Reports. Oct 2015. PMID ...
AHRQ Comparative Effectiveness Reviews. Agency for Healthcare Research and Quality. PMID 22091472. Cite journal requires , ... "Transcranial Magnetic Stimulation Cites Influence of New England Comparative Effectiveness Public Advisory Council (CEPAC)". ... The New England Comparative Effectiveness Public Advisory Council (CEPAC). Archived from the original (PDF) on 2013-12-11. ... and roadmap for future research". Autism Research. 9 (2): 184-203. doi:10.1002/aur.1567. PMC 4956084. PMID 26536383. Nizard J, ...
AHRQ Comparative Effectiveness Reviews. Rockville (MD): Agency for Healthcare Research and Quality (US). PMID 28817250. ... Research has shown that during the early preschool years (ages 3-5), children with cleft lip or cleft palate tend to have a ... There is research dedicated to the psychosocial development of individuals with cleft palate. A cleft palate/lip may impact an ... The research found that PHF8 encodes for a histone lysine demethylase, and is involved in epigenetic regulation. The catalytic ...
Comparative Effectiveness Review No. 26. Agency for Healthcare Research and Quality (AHRQ) Publication No. 11-EHC029-EF. Ganz, ... Research in Developmental Disabilities, 33(2), 406-418. Flippin, M., Reszka, S., et al. (2010). Effectiveness of the Picture ... Research indicates that "PECS is probably best used as an initial intervention to teach manding and the basic elements of what ... Research & Practice for Persons with Severe Disabilities, 33(1-2), 13-24. Conklin, C. G. (2011-03-01). Effects of implementing ...
Comparative Effectiveness Review Number 33. (Prepared by RTI International-University of North Carolina (RTI-UNC) Evidence- ... "National Institute of Mental Health Treatment of Depression Collaborative Research Program. General effectiveness of treatments ... August 2016). "Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and ... A meta-analysis examined the effectiveness of psychotherapy for depression across ages from younger than 13 years to older than ...
Journal of Comparative Effectiveness Research. 3 (5): 523-531. doi:10.2217/cer.14.41. ISSN 2042-6313. PMID 25350803. Donath, ... Quality of Life Research. 2008; 17: 1297-302. Doward LC, McKenna SP, Defining Patient-Reported Outcomes. Value in Health. 2004 ... The use of digitized PROs, or electronic patient-reported outcomes (ePROs), is on the rise in today's health research setting. ... Bottomley, Andrew; Aaronson, Neil K. (Nov 10, 2007). "International perspective on health-related quality-of-life research in ...
Journal of Comparative Effectiveness Research. 4 (6): 615-650. doi:10.2217/cer.15.43. ISSN 2042-6305. PMID 26346494. AORN - ...
Journal of Comparative Effectiveness Research. 4 (6): 615-650. doi:10.2217/cer.15.43. ISSN 2042-6305. PMID 26346494. Silveira, ... A research conducted in Switzerland with people aged 71 to 80 showed that better knowledge on advance care planning ...
Medication Adherence Interventions: Comparative Effectiveness. Closing the Quality Gap: Revisiting the State of the Science. ... US NIH Office of Behavior and Social Sciences Research (2008). "Framework for adherence research and translation: a blueprint ... Office of Behavior and Social Sciences Research. "Adherence Research Network". U.S. National Institutes of Health. Archived ... The effectiveness of two-way email communication between health care professionals and their patients has not been adequately ...
Examples include: comparative effectiveness research; independent review panels; modifying doctor incentives to focus on better ... Congressional Research Service. Retrieved November 27, 2012. U.S. Congressional Budget Office, An Analysis of the President's ... Slightly more than half of federal research and development funds go to the Department of Defense and thus overlaps with ... Funding for science research and development is mainly funded through discretionary funding through agencies such as the ...
Schmidt J (1990). "Comparative studies on the anticonvulsant effectiveness of nootropic drugs in kindled rats". Biomedica ... Epilepsy Research. 96 (3): 257-66. doi:10.1016/j.eplepsyres.2011.06.006. PMID 21737246.. ... Brain Research. 909 (1-2): 59-67. doi:10.1016/S0006-8993(01)02621-X. PMID 11478921.. ...
Funding for research is also sparse making it difficult to do further research for effectiveness of CAM.[175] Most funding for ... Comparative study of placebo-controlled trials of homoeopathy and allopathy", The Lancet, 366 (9487): 726-32, doi:10.1016/S0140 ... Use of health and research resources. Research into alternative therapies has been criticized for "...diverting research time, ... Research into alternative therapies often fails to follow proper research protocols (such as placebo-controlled trials, blind ...
Research[edit]. Efforts to better understand the mechanisms of sebum production are underway. This research aims to develop ... Benzoyl peroxide (BPO) is a first-line treatment for mild and moderate acne due to its effectiveness and mild side-effects ( ... Levy LL, Zeichner JA (October 2012). "Management of acne scarring, part II: a comparative review of non-laser-based, minimally ... Rates appear to be lower in rural societies.[22] While some research has found it affects people of all ethnic groups,[175] ...
Research[edit]. HIV[edit]. In 2007, a team of doctors in Berlin, Germany, including Gero Hütter, performed a stem cell ... March 2013). "Cost-effectiveness of Single-Use Technologies for Commercial Cell Therapy Manufacture". Am. Pharm. Rev.: 40. ISSN ... 2005). "Comparative outcome of nonmyeloablative and myeloablative allogeneic hematopoietic cell transplantation for patients ... However, recent research has shown that such lineage infidelity does not occur as a normal phenomenon[citation needed]. ...
Menke JM (January 2014). "Do Manual Therapies Help Low Back Pain?: A Comparative Effectiveness Meta-Analysis". Spine (Meta- ... Chiropractic in the United States: Training, Practice, and Research. Rockville, MD: Agency for Health Care Policy and Research ... Chiropractic in the United States: Training, Practice, and Research. Rockville, MD: Agency for Health Care Policy and Research ... A 2006 systematic cost-effectiveness review found that the reported cost-effectiveness of spinal manipulation in the United ...
... and evaluate the effectiveness of such interventions.[36] The research methods used in OHP are similar to those used in other ... Research topics[edit]. Important theoretical models in OHP research[edit]. Three influential theoretical models in OHP research ... Research methods[edit]. Main article: List of psychological research methods. The main purpose of OHP research is to understand ... Qualitative research methods[edit]. Qualitative research methods include interviews,[50][51] focus groups,[52] and self- ...
Ferguson-Pell, M., Cardi, M. D. Prototype Development and Comparative Evaluation of Wheelchair Pressure Mapping System. ... Ferguson-Pell, M. (1992) Choosing a Wheelchair System. Journal of Rehabilitation Research and Development. p.49. ... Prior to 1970, little was known about the effectiveness of wheelchair cushions and there was not a clinical method of ... "Research Device to Preproduction Prototype: A Chronology" (PDF). JRRD. 30 (4): 436-42. ISSN 0748-7711 ...
... due to recent theoretical analysis showing a comparative lack of effectiveness of such methods.[23] ... Nucleic Acids Research. 40 (20): e159. doi:10.1093/nar/gks709. PMC 3488212. PMID 22844100.. CS1 maint: Multiple names: authors ... International Journal of Scientific & Engineering Research. 3 (3): 2. Retrieved 6 March 2013.. ... Lossy data compression schemes are designed by research on how people perceive the data in question. For example, the human eye ...
... research is required to determine this.[8] Moclobemide has also been demonstrated in a single dose research study to possess ... Moclobemide has demonstrated effectiveness and efficacy in the treatment and management of major depressive disorder,[18] with ... Dingemanse J, Berlin I, Payan C, Thiede HM, Puech AJ (1992). "Comparative investigation of the effect of moclobemide and ... The effectiveness of moclobemide in agitated depression is equivalent to that of imipramine and sedative antidepressants such ...
Journal of Consumer Research. 34 (2): 162-173. doi:10.1086/518526.. *^ a b c d e McKechnie, Sally (2012). "Effects Of Discount ... Framing In Comparative Price Advertising". European Journal of Marketing. 46 (11/12): 1501-1522. doi:10.1108/03090561211259952. ... and to take advantage of opportunities that are revealed by market research. It is made up of activities, both outside and ...
These changes were widely used to study activity-patterns, but research has shown that processes associated with aging have a ... Michopoulou, E.; Nikita, E.; Henderson, C. Y. (2016-01-01). "A test of the effectiveness of the Coimbra method in capturing ... Journal of Comparative Human Biology International Journal of Paleopathology Bioarchaeology of the Near East Other ... Sillen, Andrew; Sealy, Judith C.; Nikolaas; van der Merwe, J. (1989). "Chemistry and Paleodietary Research: No More Easy ...
BMJ (Comparative Study). 2008, 337: a494 [2016-01-20]. PMC 2500200. PMID 18617488. doi:10.1136/bmj.a494. (原始内容存档于2009-02-22).. ... BMJ (Clinical research ed.) (Meta-analysis). 2012-05-16, 344: e2088. PMC 3355191. PMID 22596383. doi:10.1136/bmj.e2088.. ... The effectiveness and risks of bariatric surgery: an updated systematic review and meta-analysis, 2003-2012. JAMA Surgery (Meta ... Comparative Study). 2008-02, 5 (2): e29 [2016-01-20]. PMC 2225430. PMID 18254654. doi:10.1371/journal.pmed.0050029. (原始内容存档于 ...
For example, research shows that treatment effectiveness should include cognitive-behavioral and social learning techniques of ... "International Journal of Offender Therapy and Comparative Criminology. 48 (2): 133-48. doi:10.1177/0306624X03259472. PMID ... Some people may view such a program as providing privileges for those considered undeserving.[original research?] A judge in ... Most research regarding recidivism indicates that those ex-inmates that obtain employment after release from prison tend to ...
Prawoto, Yunan (2013). Integration of Mechanics into Materials Science Research: A Guide for Material Researchers in Analytical ... Bringas, John E. (2004). Handbook of Comparative World Steel Standards: Third Edition (PDF) (3rd. ed.). ASTM International. p. ... steel uses a specific type of strain to increase the effectiveness of work hardening on the alloy.[64] ... Verein Deutscher Eisenhüttenleute (Ed.). Steel - A Handbook for Materials Research and Engineering, Volume 1: Fundamentals. ...
2,0 2,1 2,2 2,3 2,4 2,5 2,6 2,7 2,8 Burns, A; Iliffe, S (5 February 2009). "Alzheimer's disease.". BMJ (Clinical research ed.) ... Language Performance in Alzheimer's Disease and Mild Cognitive Impairment: a comparative review. Journal of Clinical and ... Consumer Reports; Drug Effectiveness Review Project. Evaluating Prescription Drugs Used to Treat: Alzheimer's Disease Comparing ... Archives of medical research 43 (8): 677-85. PMID 23178565. doi:10.1016/j.arcmed.2012.11.009. ...
"COPD Research and Practice. 3. doi:10.1186/s40749-017-0024-y.. *^ a b c d e f g h i j k l m n o p q r s t u v w x y z aa Vestbo ... The effectiveness of alpha-1 antitrypsin augmentation treatment for people who have alpha-1 antitrypsin deficiency is unclear.[ ... "Comparative efficacy of long-acting muscarinic antagonist monotherapies in COPD: a systematic review and network meta-analysis ... Research[edit]. See also: COPD: Journal of Chronic Obstructive Pulmonary Disease. Mass spectrometry is being studied as a ...
National Congress of American Indians Policy Research Center.. *^ Estrada, Gabriel (2011). "Two Spirits, Nádleeh, and LGBTQ2 ... 2001). "Chapter Ten: Comparative Sapphism, Sharon Marcus". The Literary Channel: The Inter-National Invention of the Novel (PDF ... The Latin American lesbian movement has been the most active in Mexico, but has encountered similar problems in effectiveness ... "American Indian Culture and Research Journal. 35 (4): 167-190. doi:10.17953/aicr.35.4.x500172017344j30.. [permanent dead link] ...
"Association of Research Libraries. Retrieved 11 July 2012.. *^ Vasdev, Samhir (18 April 2016). "Why the World Bank endorses the ... "Boston College International and Comparative Law Review. 25 (1): 125-158. Retrieved 25 April 2012.. ... Partners work together to put international principles for aid effectiveness and development cooperation into practice in the ... The World Bank hosts the Open Knowledge Repository (OKR)[58] as an official open access repository for its research outputs and ...
"Comparative effectiveness of antibiotics for uncomplicated urinary tract infections: network meta-analysis of randomized trials ... Some research suggests that cranberry (juice or capsules) may decrease the number of UTIs in those with frequent infections.[53 ... Franco, AV (December 2005). "Recurrent urinary tract infections". Best Practice & Research. Clinical Obstetrics & Gynaecology. ... Some women have UTIs that keep coming back in pregnancy and currently there is not enough research on how to best treat these ...
Experimental Brain Research, Vol. 196, No. 4, 2009, pp565-571. Holmes, E. A., and Mathews, A., Mental imagery in emotion and ... Baird, C. L., and Sands, L., A pilot study of the effectiveness of guided imagery with progressive muscle relaxation to reduce ... A systematic review and meta-analysis of comparative outcome studies. Psychological Medicine, Vol. 40, No. 12, 2010, pp1943- ... Meador, K. S., Fishkin, A. S., and Hoover, M., Research-based strategies and programs to facilitate creativity. In Fishkin, A. ...
2010). "International comparison of comparative effectiveness research in five jurisdictions: insights for the US". ... Leichter, Howard M. (1979). A comparative approach to policy analysis: health care policy in four nations. Cambridge: Cambridge ... Finally, industry coverage covers the production and distribution of healthcare products for research and development. The ... Initially successful at combating infectious diseases, the effectiveness of the socialized model declined with underinvestment ...
"Comparative effectiveness of continuation and maintenance treatments for persistent depressive disorder in adults". The ... Research shows that 1 in 4 of those who switch medications get better results regardless of whether the second medication is an ...
"Integrative and Comparative Biology. 43 (1): 166-177. doi:10.1093/icb/43.1.166. PMID 21680421. Archived from the original on ... This change in the atmosphere increased their effectiveness as nurseries of evolution.[57] While eukaryotes, cells with complex ... Sometimes the smoking gun is discovered by a fortunate accident during other research. For example, the discovery by Luis ... "HOMO: Journal of Comparative Human Biology. 52 (1): 3-58. doi:10.1078/0018-442X-00019.. ...
New York: The Rockefeller Institute for Medical Research.. *^ Another publication of similar regimen was Hill LW, Eckman RS ( ... There is little evidence for the effectiveness of low-carbohydrate diets for people with type 1 diabetes.[1] For certain ... 2018). "Comparative effects of different dietary approaches on blood pressure in hypertensive and pre-hypertensive patients: A ... Much of the research comparing low-fat vs. low-carbohydrate dieting has been of poor quality and studies which reported large ...
... in helping to guide future research concerning the effectiveness of balance and gait training programs in the management of PSP ... Buée L, Delacourte A (October 1999). "Comparative biochemistry of tau in progressive supranuclear palsy, corticobasal ... Internationally, several organizations serve the needs of patients with PSP and their families and support research. ... and currently the majority of research on the subject consists of case reports involving only a small number of patients. ...
Carr, Alan (2008). What works with children, adolescents, and adults: a review of research on the effectiveness of ... Frank, Jerome D; Frank, Julia (1991) [1961]. Persuasion and healing: a comparative study of psychotherapy (3rd ed.). Baltimore ... Empirical research[edit]. Research by Laska et al. (2014)[35] Factor. % of Variability. in Outcome ... "Psychotherapy: Theory, Research, Practice, Training. 44 (3): 239-299.. *^ a b Frank & Frank 1991; the legacy of Frank's work is ...
Journal of Research in Psychology, 26, 258-272. *^ a b Fisher, C. D. & Noble, C. S. (2004). A within-person examination of ... Journal of Comparative and Physiological Psychology, 63, 28-33. *^ a b Eisenberger, R., Park, D. C., & Frank, M. (1976). ... Daniels, A. C., & Daniels, J. E. (2006). Performance Management: Changing Behavior that Drives Organizational Effectiveness. ... further research should be done to provide evidence for or against its existence. This research could be useful for personnel ...
This was ascribed to the fact that every new drug competes in effectiveness with every other drugs known so far, other economic ... As of 2008, the United States is the leader in medical research, including pharmaceutical development. U.S. drug prices are ... Fonseca, Massard da; Shadlen, Kenneth C. (20 April 2017). "Promoting and regulating generic medicines: Brazil in comparative ... It includes pre-clinical research (microorganisms/animals) and clinical trials (on humans) and may include the step of ...
"Journal of Research in Pharmacy Practice. 5 (1): 16-21. doi:10.4103/2279-042X.176556. ISSN 2319-9644. PMC 4776542. PMID ... "Drugs During Pregnancy and Lactation: Handbook of Prescription Drugs and Comparative Risk Assessment. Gulf Professional ... "Review of Cannabinoids and their Antiemetic Effectiveness". Drugs. 25 (1): 52-62. doi:10.2165/00003495-198300251-00006. ISSN ...
Reports of the Research Committee of the Society of Antiquaries of London. London: Thames and Hudson. ISBN 0-500-99027-1. .. ... Medieval Worlds, Official Website Comparative and interdisciplinary articles about the period.. *Medieval History Database ( ... which increased the effectiveness of cavalry as shock troops. A technological advance that had implications beyond the military ... although they are not supported by historical research.[338] ...
The effectiveness of these laws empire-wide is debatable. Christianization of the central Balkans is documented at the end of ... Data From Ann Arbor, Michigan: Inter-university Consortium for Political and Social Research (ICPS). ... "Power and Conversion: A Comparative Study of Christianization in Scandinavia" (PDF), Occasional Papers in Archaeology, 34 ... 22, 6, Viking Society for Northern Research, University College London, 1989, p. 370. ...
... youll have the power to influence the arthritis research conducted and supported by PARTNERS. Learn more about how you can get ... Join PARTNERS: You Have a Role in Research. You will have the power to influence the research conducted and supported by ... Provide ideas for research topics -- to help us decide which research studies to support. ... Its OK if you dont know anything about research. We need people from diverse communities. No matter what work you do, your ...
Background Comparative effectiveness research in spine surgery is still a rarity. In this study, pain alleviation and quality ... Comparative effectiveness research in spine surgery is still a rarity. In this study, pain alleviation and quality of life (QoL ... Comparative effectiveness Spine registry SWISSspine Total disc arthroplasty Benchmark Abbreviations. ALIF. Anterior lumbar ... We are indebted to the SWISSspine and Spine Tango registry groups who made this research possible by populating the database ...
An IBD specialist says investigators must become more creative in their approach to comparative effectiveness research. ... IBD effectiveness trials are needed to foster evidence-based changes in clinical practice, but remain challenging to fund and ... Ideally, comparative effectiveness research (CER) also identifies the features that predict which intervention would be most ... This type of research is intended to foster evidence-based changes in practice that reduce costs and improve patient care. ...
The Comparative Effectiveness Research as Topic search strategy has been designed to retrieve citations "about" CER. ... PubMed, HSRProj, and ClinicalTrials.gov Search Strategies for Informing Comparative Effectiveness Research. Return to CER ... Comparative Effectiveness Research as Topic, HSRProj CER Search, ClinicalTrials.gov CER Search, ... effective OR effectiveness) AND (comparative OR compared OR "costs and cost analysis" OR "cost-benefit analysis" OR "evidence- ...
... involve comparisons of relative treatment costs in addition to relative treatment efficacy.Comparative effectiveness research ( ... Part of the mission of Health Outcomes Research in Medicine is to present evidence from outcomes research to help with ... Stull, D. (2012). Outcomes research and comparative effectiveness. Health Outcomes Research in Medicine, 3(2), e55-e56. https ... Comparative effectiveness research (CER) has increasingly been a focal point of health technology assessments. As defined by ...
Comparative Effectiveness Research - Collaborative Initiative (CER-CI). Advancing Appropriate Use of Comparative Evidence to ... for advancing appropriate use of outcomes research including comparative effectiveness research (CER) to improve patient health ... AMCP, ISPOR and NPC have joined forces to establish the Comparative Effectiveness Research Collaborative Initiative (CER-CI) ... including comparative effectiveness research [CER]) in a wide variability of payer coverage and formulary decisions. ...
comparative effectiveness research. PCORI. Patient-Centered Outcomes Research Institute. PCORTF. Patient-Centered Outcomes ... Comparative Effectiveness Research. J.A. Hirsch, P.W. Schaefer, J.M. Romero, J.D. Rabinov, P.C. Sanelli and L. Manchikanti ... An understanding of comparative effectiveness research as a core topic is important for neuroradiologists. It can be used in a ... Comparative effectiveness research: the view from the NHLBI. J Am Coll Cardiol 2009;53:1084-86. ...
... has established priorities and processes for funding comparative clinical effectiveness research (CER)-which is research that ... evaluates and compares health outcomes and the clinical effectiveness, risks, and benefits of two or more medical treatments, ... has established priorities and processes for funding comparative clinical effectiveness research (CER)-which is research that ... Comparative Effectiveness:. Initial Assessment of the Patient-Centered Outcomes Research Institute. GAO-15-301: Published: Mar ...
... clinicians and others in the health care community while developing comparative clinical effectiveness research studies will ... Comparative Clinical Effectiveness Research Wants Better Patient and Clinician Involvement. by Nancy Needhima on April 22, 2012 ... clinicians and others in the health care community while developing comparative clinical effectiveness research studies will ... Protection and Affordable Care Act of 2010 created PCORI to fund and promote comparative clinical effectiveness research (CER) ...
2007) Research on the Comparative Effectiveness of Medical Treatments: Issues and Options for an Expanded Federal Role ( ... We return to CTLS below in the context of comparative effectiveness research, for which it is a interesting model. ... How should the economic cost of treatment enter the equation? There is little dispute that comparative effectiveness research ... Bandit solutions provide unified ethical models for randomized clinical trials and comparative effectiveness research. William ...
Read a description of Major Depression Comparative Effectiveness study and view aims, objectives, timeline, status, and contact ... Comparative Effectiveness of Treatment for Major Depression-Utilize commercially available national claims data to evaluate the ... Home / Patient Care / NRN Studies / Major Depression Comparative Effectiveness Study - Expanding DARTNet ... Comparative Safety Study of Antidepressants-Measure rates of adverse effects to include the most common medical side effects ...
This research can help patients, doctors, and others make decisions to improve health care. ... The Patient Protection and Affordable Care Act established a fund to support research comparing the effectiveness of available ... Comparative Effectiveness Research:. Activities Funded by the Patient-Centered Outcomes Research Trust Fund. GAO-18-311: ... nonprofit corporation established to carry out and improve comparative clinical effectiveness research (CER), which evaluates ...
13/02/2015 Instrumental variable methods in comparative safety and effectiveness research 17/06/2013 Good research practices ... for comparative effectiveness research: Defining, reporting and interpreting nonrandomized studies of treatment effects using ...
... Vicki Fung, PhD; Richard J. Brand, ... Create specific Medicare data sets for top comparative effectiveness priority topics identified by the Institute of Medicine.32 ... RESEARCH DESIGN AND ANALYTIC STRATEGIES. A substantial body of literature describes the limitations of using observational data ... This lag hinders the ability to compare newer therapies, for which effectiveness and safety information could have the most ...
"Its especially important for comparative effectiveness research because this research is meant primarily to serve patients and ... Comparative Effectiveness Research Fellows named for 2017 Date: 08/28/17. COLUMBIA, MO. - Ten journalists have been chosen for ... Specifically, it funds comparative clinical effectiveness research, or CER, as well as supports work that will improve the ... the third class of the AHCJ Fellowship on Comparative Effectiveness Research. The fellowship program was created with support ...
Comparative Clinical Effectiveness, Comparative Clinical Effectiveness Research, Comparative Effectiveness, Concerns, ... Although comparative clinical effectiveness research is distinct from comparative cost effectiveness research - it is likely ... Comparative Clinical Effectiveness Research: Good News In Shades Of Gray. Val Jones on February 19, 2009 ... What Is Comparative Clinical Effectiveness Research?. The new economic stimulus bill, also known as The American Recovery and ...
"Welcome to the Journal of Comparative Effectiveness Research". Journal of Comparative Effectiveness Research. 1 (1): 1-3. doi: ... "Querying stakeholders to inform comparative effectiveness research". Journal of Comparative Effectiveness Research. 6 (3): 265- ... The Patient-Centered Outcomes Research Institute (PCORI) was established to conduct comparative effectiveness research but the ... Comparative effectiveness research adopts many of the same approaches and methodologies as cost-effectiveness analysis, ...
Archives for Comparative Effectiveness Research. Geisinger Program Slows Spending Growth on Biologics. A comparative ... "Comparative effectiveness research, to me, is very critical when you have options, and when youre considering the […] more ... Three articles in the Journal of Comparative Effectiveness Research focus on the work and recommendations of a CER-centric ... Clifford Goodman, senior vice president and director at the Center for Comparative Effectiveness Research at the Lewin Group, ...
You are here: Home / Archives for Comparative Effectiveness Research. ICER Set to Review Canakinumab for Atherosclerosis. The ... "Comparative effectiveness research, to me, is very critical when you have options, and when youre considering the […] more ... Although comparative effectiveness research (CER) is still a relatively recent scientific discipline, its rapid expansion has ... Three articles in the Journal of Comparative Effectiveness Research focus on the work and recommendations of a CER-centric ...
... Doctoral dissertation, Harvard University, ... Medical devices bring a unique set of challenges for comparative effectiveness research. In this dissertation, I develop ... A recent focus in health care policy is on comparative effectiveness of treatments--from drugs to behavioral interventions to ... statistical methods for comparative effectiveness estimation and illustrate the methodology in the context of three different ...
The second volume in the Health Services Research series provides a series of perspectives on comparative effectiveness ... research. Motivated by concern from the general public, governments in virtually ... Comparative Effectiveness Research presents a series of chapters of relevance including introductions to areas that are being ... Implementation Science and Comparative Effectiveness Research Ann C. Bonham, Mildred Z. Solomon, Brian Mittman, Alexander K. ...
So, is it worth wasting our time and money on comparative effectiveness research? Im hoping that this is a new day - the ... Are We Mature Enough to Make Use of Comparative Effectiveness Research?. Feb 27, 2009. • 39 ... What other way can one force physicians and hospitals to pay attention to comparative effectiveness research? As I commented to ... What other way can one force physicians and hospitals to pay attention to comparative effectiveness research? As I commented to ...
The journal covers all aspects of comparative effectiveness research, including patient-centered outcomes research, ... The Journal of Comparative Effectiveness Research is a peer-reviewed medical journal that was established in 2012 and is ... "Journal of Comparative Effectiveness Research". 2016 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. ... The editors-in-chief are Sheldon Greenfield (University of California, Irvine) and Eugene Rich (Mathematica Policy Research). ...
New UCSF Initiative to Improve Access to and Analysis of Large Health Data Sets for Comparative Effectiveness Research August ... Accelerating Research to Improve Health. The UCSF Clinical and Translational Science Institute (CTSI) is part of the Clinical ... CTSI is providing services and resources to support Patient-Centered Outcomes Research Institute grants. ... CTSI Involved in Three Awards to Shape National Clinical Research Data Network ...
... Crit Care Med. ... assess the importance of including do-not-resuscitate status in critical care observational comparative effectiveness research ... of early do-not-resuscitate status into more administrative databases may improve observational comparative effectiveness ... 2Center for Quality of Care Research, Baystate Medical Center, Springfield, MA. 3Division of General Internal Medicine, ...
... it also serves as a harbinger for the penurious nature of future government funding for comparative effectiveness research.. - ... the governments new paradigm for requiring significant industry sponsorship to fund their comparative effectiveness research ( ...
After a prolonged debate over government-sponsored comparative effectiveness research, Congress decided to authorize it in the ... After a prolonged debate over government-sponsored comparative effectiveness research, Congress decided to authorize it in the ... Trendspotter: Comparative Effectiveness Research to Cut Costs Without Rationing. @media screen and (max-width: 468px) { .video- ...
Peer-led and Telehealth Comparative Effectiveness Research (CER) Adoption for Diabetes Prevention and Management. The safety ... innovative interventions to increase adoption of findings from comparative effectiveness research (CER) for diabetes management ... To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For ... To learn more about this study, you or your doctor may contact the study research staff using the contact information provided ...
Institutional Comparative Effectiveness Research Mentored Career Development Award (KM1) RFA-OD-10-011. NIH ... 4) Feasibility of research topic (including time necessary for research).. The Comparative Effectiveness Research-Coordination ... "Comparative effectiveness research is the conduct and synthesis of research comparing the benefits and harms of different ... research-intensive institutions to support mentored career development in support of comparative effectiveness research (CER) ...
Private, voluntary or public? Comparative cost-effectiveness in community mental health care ... Comparative cost-effectiveness in community mental health care. Policy and Politics, 27 (1). pp. 25-42. ISSN 0305-5736 ... Personal Social Services Research Unit. Subjects:. R Medicine , RZ Other systems of medicine. B Philosophy. Psychology. ... Mission Statement & FAQs , Contact us , Takedown Policy , LSE Experts , LSE Research Online supports OAI 2.0 with a base URL of ...
  • PCORI will ensure that its research is not construed as mandates for practice guidelines or coverage recommendations. (nursingworld.org)
  • PCORI is developing a research agenda and plan for commissioning PCOR. (nursingworld.org)
  • The Patient-Centered Outcomes Research Institute (PCORI) was established to conduct comparative effectiveness research but the Patient Protection and Affordable Care Act (PPACA) prohibits it from using cost per QALY ICER thresholding. (wikipedia.org)
  • The Patient-Centered Outcomes Research Institute (PCORI) has established priorities and processes for funding comparative clinical effectiveness research (CER)-which is research that evaluates and compares health outcomes and the clinical effectiveness, risks, and benefits of two or more medical treatments, services, or items such as health care interventions-and is developing dissemination plans, consistent with the legislative requirements of the Patient Protection and Affordable Care Act (PPACA). (gao.gov)
  • PCORI also developed a research agenda to identify how each priority would be addressed. (gao.gov)
  • PCORI has established a multi-step research funding process designed to assess and select contract applications for funding. (gao.gov)
  • Per legislative requirement, PCORI is developing a peer review assessment process to review final reports submitted by contract awardees and is in the process of developing a plan for the dissemination of funded research potentially beginning in 2015, in coordination with the Agency for Healthcare Research and Quality. (gao.gov)
  • PCORI has started awarding contracts for research and plans to award additional contracts through 2019. (gao.gov)
  • As of October 2014, PCORI has awarded 360 contracts to fund research projects, committing a total of $670.8 million to them. (gao.gov)
  • PCORI expects to commit about $2.6 billion to research contracts, out of $3.5 billion in total estimated spending. (gao.gov)
  • PCORI has developed initial plans for evaluating the institute's efforts against its three strategic goals, which are to increase information, speed implementation, and influence research. (gao.gov)
  • In its strategic plan, PCORI notes that these are meant to be long-term measures because research typically requires several years to complete and additional years for the results to be disseminated and implemented. (gao.gov)
  • PCORI, which began operation in 2010, is required to identify research priorities, establish a research project agenda, fund research consistent with its research agenda, and disseminate research results, among other things. (gao.gov)
  • To fund PCORI, PPACA established the Patient-Centered Outcomes Research Trust Fund, through which the institute is expected to receive an estimated $3.5 billion from fiscal years 2010 through 2019. (gao.gov)
  • Anne C. Beal, M.D., M.P.H., of the Patient-Centered Outcomes Research Institute (PCORI), Washington, D.C., presented the article at a JAMA media briefing at the National Press Club. (medindia.net)
  • The PCORI mission statement commits to producing and promoting high-integrity research that is 'guided by patients, caregivers, and the broader healthcare community. (medindia.net)
  • The founding legislation required PCORI to develop national priorities for research and a research agenda, and to post both for a 45- to 60-day public comment period before major funding for research could begin. (medindia.net)
  • The Patient-Centered Outcomes Research Institute (PCORI) made about $2 billion in commitments for awards in fiscal years 2010 through 2017. (gao.gov)
  • PCORI is a federally funded, nonprofit corporation established to carry out and improve comparative clinical effectiveness research (CER), which evaluates and compares the health outcomes and the clinical effectiveness, risks, and benefits of two or more medical treatments, services, or items. (gao.gov)
  • PCORI provides funding through award commitments from the Patient Centered Outcomes Research Trust Fund (Trust Fund) and may pay these awards over multiple years. (gao.gov)
  • Of the $2 billion PCORI committed as of the end of fiscal year 2017, about $1.6 billion (or 79 percent of its commitments) is for research awards, and $325 million (or 16 percent) is for building the capacity to use existing health data for research. (gao.gov)
  • Through fiscal year 2017, commitments for dissemination and implementation awards-intended to share CER findings with potential users of this research-were limited because most PCORI-funded research was still underway. (gao.gov)
  • As most PCORI-funded CER had not yet been completed due to the time needed to conduct this research, HHS efforts focused instead on the dissemination and implementation of CER funded by other federal entities. (gao.gov)
  • CTSI featured in Nature news blog announcing PCORI research grants. (ucsf.edu)
  • Earlier this fall, PCORI (the Patient Centered Outcomes Research Institute) released a request for funding applications for comparative effectiveness studies of Multiple sclerosis (MS) disease modifying therapies (DMTs). (mscenter.org)
  • WASHINGTON, DC - The Patient-Centered Outcomes Research Institute (PCORI) Board of Governors today approved the development of two new PCORI Funding Announcements (PFAs) that together will offer up to $41 million in support of comparative clinical effectiveness research (CER). (pcori.org)
  • Pregnancy may motivate women to seek treatment, and PCORI wants to fund research that addresses some of the many barriers to care that they face. (pcori.org)
  • The Patient-Centered Outcomes Research Institute (PCORI) represents an effort by the US government to address this shortcoming by funding comparative effectiveness research (CER). (npcnow.org)
  • these priorities will set the tone for all of the institute's future activities.The research also highlights the difficult questions PCORI will face as the public dialogue on its national research priorities and research agenda begins. (npcnow.org)
  • Last week the U.S. Government Accountability Office (GAO) appointed several new members to the board of the Patient-Centered Outcomes Research Institute (PCORI). (medicallessons.net)
  • PCORI, comparative effectiveness and the ACA: improving patient outcomes or cookbook medicine? (freethesaurus.com)
  • PCORI committed $68 million in April to develop the national data network through the creation or expansion of up to eight health system-based Clinical Data Research Networks and up to 18 Patient-Powered Research Networks organized by groups of patients interested in participating in clinical research. (healthcareitnews.com)
  • The Affordable Care Act established the Patient-Centered Outcomes Research Institute (PCORI), a private nonprofit entity, to oversee such research. (hhs.gov)
  • The Affordable Care Act created a non-profit Patient-Centered Outcomes Research Institute (PCORI) to conduct research that compares the clinical effectiveness of medical treatments. (philips.com)
  • The panel included representatives of the American Diabetes Association and the American Heart Association as well as experts from industry, academic and government research institutes, and the Patient-Centered Outcomes Research Institute (PCORI). (biomedcentral.com)
  • Similar to CER, patient-centered outcomes research (PCOR) is designed to inform health care decisions by providing evidence on the effectiveness, benefits and harms of different treatment options for different patients. (nursingworld.org)
  • Two organizations focused on CER and PCOR are the Agency for Healthcare Research and Quality and the Patient Centered Outcomes Research Institute. (nursingworld.org)
  • Patient-centered outcomes research" (PCOR) is the type of research that will be the focus of PCORI's work. (nursingworld.org)
  • She conducts research ranging from randomized controlled trials to systematic reviews focusing on quality of care, evidence-based practice among clinicians and outcomes research in healthcare delivery systems. (nursingworld.org)
  • Health Outcomes Research in Medicine , 3 (2), e55-e56. (rti.org)
  • Part of the mission of Health Outcomes Research in Medicine is to present evidence from outcomes research to help with decisions about which treatments to pursue and the efficacy of those treatments. (rti.org)
  • AMCP, ISPOR and NPC have joined forces to establish the Comparative Effectiveness Research Collaborative Initiative (CER-CI) for advancing appropriate use of outcomes research including comparative effectiveness research (CER) to improve patient health outcomes. (ispor.org)
  • Since there are a limited number of accepted principles for the interpretation of non-experimental design outcomes research studies for drug formulary and health care decisions, a consensus-based set of principles, combined with educational training and tools, would promote the development, application, and interpretation of appropriate evidence for health care technology and enhance the formulary decision-making process. (ispor.org)
  • The goal of the CER Collaborative Initiative is to provide greater uniformity and transparency in the use and evaluation of outcomes research information including observational studies for coverage and health care decision making by providing a user-friendly toolkit to help decision makers navigate through the various types of observational study methods used to generate outcomes research information for evidence-based health care decision making. (ispor.org)
  • The goal of Part 1 is to develop a compendium of papers on"Interpreting Outcomes Research Studies for Health Care Decisions" for four outcomes research study types: a) prospective observational studies, b) retrospective observational database studies, c) modeling studies and d) indirect treatment comparison studies. (ispor.org)
  • The goal of Part 2 is to identify a framework to assess evidence across multiple outcomes research study methods (body of evidence) including experimental design studies [randomized clinical trial studies - RCTs] and observational studies. (ispor.org)
  • The PPACA states: The Patient-Centered Outcomes Research Institute. (wikipedia.org)
  • and (5) accelerating patient-centered outcomes research and methodological research. (gao.gov)
  • Added participation by patients, clinicians and others in the health care community while developing comparative clinical effectiveness research studies will make such studies far more constructive in clinical decision-making, states the Patient-Centered Outcomes Research Institute, in an article published in the April 18 issue of JAMA , a theme issue on comparative effectiveness research. (medindia.net)
  • The institute developed a definition of patient-centered outcomes research that emphasizes the voice of the patient in assessing health care options. (medindia.net)
  • However, as health outcomes research enabled by electronic medical records becomes common ( 6 ), comparative effectiveness research (CER), which is logically, if not by name, a kind of clinical trial ( 7 ), will extend the duration of ethical questions, and the number of patients affected by such questions, almost without bound. (pnas.org)
  • The journal covers all aspects of comparative effectiveness research, including patient-centered outcomes research, pharmacoeconomics and health economics, relating to diagnostics, therapeutics, surgical procedures, or other healthcare services or options. (wikipedia.org)
  • We found that the Patient-Centered Outcomes Research Institute and Department of Health and Human Services expect to receive about $4 billion from the fund by the end of fiscal year 2019. (gao.gov)
  • Gruman: Tell me how your organization views the relationship between CER and patient-centered outcomes research (PCOR). (cfah.org)
  • The fellowship program was created with support from the Patient-Centered Outcomes Research Institute to help reporters and editors produce more accurate in-depth stories on medical research and how medical decisions are made. (healthjournalism.org)
  • The Patient-Centered Outcomes Research Institute , an independent nonprofit, nongovernmental organization located in Washington, D.C., was authorized by Congress in 2010 to improve the quality and relevance of evidence available to help patients, caregivers, clinicians, employers, insurers and policymakers make informed health decisions. (healthjournalism.org)
  • A comparative study of new biologic and small-molecule treatments for inflammatory bowel disease is slated to receive $2.4 million in grant funding from the Patient-Centered Outcomes Research Institute and the Crohn's and Colitis Foundation (CCF). (healtheconomics.com)
  • CTSI is providing services and resources to support Patient-Centered Outcomes Research Institute grants. (ucsf.edu)
  • To get a better understanding of comparative effectiveness research and its relationship with oncology services, The ASCO Post recently spoke with Gary Lyman, MD, Professor of Medicine at Duke University and the Duke Cancer Institute, where he is Director of the Comparative Effectiveness and Outcomes Research Program. (ascopost.com)
  • The Center for Health Services and Outcomes Research is delighted to share its experience in Comparative Effectiveness Research. (jhsph.edu)
  • The SVI (stent versus indomethacin) trial (NCT024762279) by the US cooperative for Outcomes Research in Endoscopy (USCORE) group is an ongoing non-inferiority trial that compares indomethacin alone to the combination of indomethacin and PDS in 1430 high risk patients with the primary outcome of pancreatitis. (centerwatch.com)
  • Methods: The Task Force was commissioned and a Chair was selected by the International Society for Pharmacoeconomics and Outcomes Research Board of Directors in October 2007. (ispor.org)
  • The Patient-Centered Outcomes Research Institute Board of Governors selected a consortium led by the Harvard Pilgrim Health Care Institute to serve as the coordinating center for a new national data network designed to enhance the nation's ability to conduct patient-centered comparative effectiveness research. (healthcareitnews.com)
  • In response to the need for data to support comparative effectiveness research (CER), or patient-centered outcomes research, the Agency for Healthcare Research and Quality (AHRQ) and CDC's National Program of Cancer Registries (NPCR) developed a special data collection enhancement project to help answer specific CER questions through the development of analytic datasets. (cdc.gov)
  • CER also uses systematic reviews, evidence-quality appraisal, and health outcomes research to provide a methodologic framework for assessing biologic patient subgroups. (blogspot.com)
  • Value in Health (ISSN 1098-3015) publishes papers, concepts, and ideas that advance the field of pharmacoeconomics and outcomes research as well as policy papers to help health care leaders make evidence-based decisions. (ispor.org)
  • International Society for Pharmacoeconomics and Outcomes Research (ISPOR) is a nonprofit, international, educational and scientific organization that strives to increase the efficiency, effectiveness, and fairness of health care resource use to improve health. (ispor.org)
  • NEW YORK (GenomeWeb News) - When President Barack Obama included over $1 billion in the federal stimulus spending bill in February to study which healthcare treatments are most beneficial for most patients and most cost-effective, he signaled that comparative effectiveness research likely will be part of his administration's effort to change the healthcare system. (genomeweb.com)
  • 1 , 2 Dr Lind's historic controlled study of 6 different treatments for scurvy was, in reality, the first true "evidence" of comparative effectiveness research (CER). (ajnr.org)
  • Dr. Ted Feldman, NorthShore University HealthSystem, Evanston IL, explains the challenges involved in comparing the effectiveness of treatments. (scai.org)
  • Although randomized clinical trials are the gold standard for establishing the effectiveness of medical treatments, it is widely recognized that they raise nontrivial ethical issues. (pnas.org)
  • The Patient Protection and Affordable Care Act established a fund to support research comparing the effectiveness of available treatments. (gao.gov)
  • This study examines the key features of government agencies created in Australia, France, Germany, and the United Kingdom to lead research into the comparative effectiveness of medical treatments, procedures, and technologies. (commonwealthfund.org)
  • A part of the recent discussions about U.S. health system reform has focused on the need for better evidence on the comparative effectiveness of various clinical treatments. (commonwealthfund.org)
  • Just knowing more about the comparative effectiveness of symptomatic treatments would help. (cfah.org)
  • The Institute for Clinical and Economic Review (ICER) on Friday released a Draft Evidence Report assessing the comparative clinical effectiveness and value of treatments for moderate-to-severe plaque psoriasis. (healtheconomics.com)
  • The Institute for Clinical and Economic Review (ICER) says upcoming reports will focus on the comparative clinical effectiveness and value of high-risk prostate cancer and hereditary amyloidosis treatments. (healtheconomics.com)
  • A recent focus in health care policy is on comparative effectiveness of treatments--from drugs to behavioral interventions to medical devices. (harvard.edu)
  • Comparative Effectiveness Research presents a series of chapters of relevance including introductions to areas that are being incorporated when comparing treatments, country-specific applications, patient-centred approaches, and modern methods. (springer.com)
  • A new clinical review by experts at The University of Nottingham says there is very little research evidence to show which treatments work best and whether expensive treatments are any better than traditional ones. (healthcanal.com)
  • What is needed is a whole rethink about acne research into which treatments should be started first, how well do commonly used treatment compare against each other, which treatments should be used for maintaining control and which combinations are best. (healthcanal.com)
  • By establishing legal incentives for evidence-based medicine, safe harbors founded on comparative effectiveness research results also would reduce the need for defensive medicine and its unnecessary, costly treatments. (freethesaurus.com)
  • The Institute of Medicine identified 25 of the most urgently needed areas for research of which three pertain to Urology: screening for prostate cancer, comparing effectiveness of treatments for localized prostate cancer, and use of imaging in diagnosing, staging, and monitoring cancer patients. (elsevier.com)
  • Insufficient evidence regarding the effectiveness of medical treatments has been identified as a key source of inefficiency in the U.S. healthcare system. (hhs.gov)
  • Unlike randomized controlled trials (RCTs), which examine the efficacy of tests, treatments, or quality improvement strategies in highly specified samples, CER addresses their effectiveness in a broader and more diverse set of populations and settings. (hhs.gov)
  • Objective To investigate the comparative effectiveness of all treatments for patellofemoral pain (PFP). (bmj.com)
  • The ongoing work of the Depression Clinical and Research Program (DCRP) at Massachusetts General Hospital is helping to define depression treatments for the field. (massgeneral.org)
  • The DCRP conducts leading-edge research in the area of depression, with a focus on testing novel antidepressant treatments and developing new tools to understand the biological changes that occur in this condition. (massgeneral.org)
  • In 2015, the Alzheimer's Drug Discovery Foundation convened an advisory panel on "The Prevention of Dementia and Mild Cognitive Impairment as Variables to Consider In the Comparative Effectiveness of Treatments for Common Chronic Conditions. (biomedcentral.com)
  • The Obama administration has made a major investment in comparative effectiveness research (CER) to learn what treatments work best for which patients. (dukeupress.edu)
  • Boston, MA, USA - Health care companies face increased pressure to compare the effectiveness of new treatments as early as possible. (ispor.org)
  • While randomized head-to-head trials are the gold standard for comparing treatments, the new approach can provide indirect comparative evidence when such trials are not available. (ispor.org)
  • One alternative that avoids some of the challenges of head-to-head prospective trials is network meta-analysis, which allows investigators to make inferences about the effectiveness of interventions that have not been directly compared with one another. (mayoclinic.org)
  • Comparative effectiveness research (CER) is the direct comparison of existing health care interventions to determine which work best for which patients and which pose the greatest benefits and harms. (wikipedia.org)
  • The Institute for Clinical and Economic Review provides independent evaluation of the clinical effectiveness and comparative value of health care interventions, while also overseeing the New England Comparative Effectiveness Public Advisory Council (CEPAC), an independent body of physicians and patient representatives that aids patients, physicians and policymakers in the application and use of comparative effectiveness information to improve the quality and value of healthcare in the region. (wikipedia.org)
  • The initial portfolio of funded research is expected to cover a range of conditions and interventions, to be exemplary of stakeholder-engaged research, and to be highly aligned with the criteria. (medindia.net)
  • Our work will include comparative effectiveness research, with an emphasis on causal inference methods for complex longitudinal data from both observational studies and randomized trials, e.g. to assess effects of interventions on cardiovascular disease, cancer, and others. (ki.se)
  • The overall objective of this protocol is to implement evidence-informed, innovative interventions to increase adoption of findings from comparative effectiveness research (CER) for diabetes management and prevention in South Florida older veterans. (clinicaltrials.gov)
  • The low prevalence of CE research exists across CE studies with a broad array of interventions and characteristics. (harvard.edu)
  • Comparative effectiveness research (CER) involves comparing the benefits and harms of interventions for clinical conditions, which will assist patients, providers, and policy makers in formulating informed decisions that will improve health care [ 1 ]. (plos.org)
  • To further evaluate effectiveness and assess less common or delayed toxicities in the broad cancer population, additional sources of evidence are needed to guide the evaluation and approval of new interventions and better guide clinical decisions in the oncology setting. (ascopost.com)
  • Although we don't specifically link cost savings to comparative effectiveness research, identifying interventions that provide the most value to patients is fundamental, and any cost benefits may certainly be a desired outcome. (ascopost.com)
  • The Institute of Medicine Committee on Comparative Effectiveness Research Prioritization was charged with developing a portfolio of priority topics that reflected balance across research areas, populations, type of interventions, and methodologies. (nap.edu)
  • Comparative Effectiveness of Two Tobacco Cessation Interventions for Employees of Partners HealthCare Inc. (centerwatch.com)
  • Lahey Hospital & Medical Center launched the Comparative Effectiveness Research Institute (CERI) to better assess quality and effectiveness of medical care interventions. (lahey.org)
  • Comparative effectiveness research is the conduct and synthesis of research comparing the benefits and harms of different interventions and strategies to prevent, diagnose, treat, and monitor health conditions in "real world" settings. (nih.gov)
  • Five groups (A-E) will be evaluated to determine the effectiveness of three interventions. (biomedcentral.com)
  • 2 Similarly, research funders and researchers are increasingly focused on translating new interventions and technologies from the laboratory to clinical practice and then healthcare policy in order to establish and implement new standards of high quality care and improve patient outcomes. (bmj.com)
  • As membership-based organizations representing the leadership in managed care pharmacy, the research community and the pharmaceutical industry, AMCP, ISPOR and NPC are uniquely positioned to collaborate in advancing understanding, interpretation and appropriate use of observational studies results (including comparative effectiveness research [CER]) in a wide variability of payer coverage and formulary decisions. (ispor.org)
  • Traditional observational comparative effectiveness research is conducted using large data sets, such as claims databases. (nih.gov)
  • The target trail framework provides a conceptual framework and causal analytical methods that allows us to address such research questions and emulate a hypothetical experiment by using observational data. (ki.se)
  • To assess the importance of including do-not-resuscitate status in critical care observational comparative effectiveness research. (nih.gov)
  • Among patients with septic shock, do-not-resuscitate status acts as a strong confounder that may inform past discrepancies between observational and randomized studies of activated protein C. Inclusion of early do-not-resuscitate status into more administrative databases may improve observational comparative effectiveness methodology. (nih.gov)
  • Methods: We conducted an observational study of clinical trials addressing priority research topics defined by the Institute of Medicine and conducted in the US between 2007 and 2010. (harvard.edu)
  • DARTNet can be used for observational comparative effectiveness research, which may provide important information about safe and effective health care. (annals.org)
  • The Distributed Ambulatory Research in Therapeutics Network (DARTNet) is a federated network of electronic health data that was created to facilitate advanced observational comparative effectiveness research and examine outcomes associated with prescription medications and devices. (annals.org)
  • Comparative effectiveness of any particular treatment can be established by interventional clinical trials, observational real-world evidence studies, or systematic review and meta-analysis. (linguamatics.com)
  • Finally, it also used state-of-the-art statistical and econometric comparative effectiveness methods to mimic the effect of random assignment and control for sources of confounding inherent in large observational studies. (doaj.org)
  • Fourth, CER uses observational or pragmatic research methods designed to enhance generalizability, including treatment allocation and the measurement of outcomes in real-world settings that are relevant to patients. (hhs.gov)
  • The Committee on Comparative Effectiveness Research Prioritization released 100 topics that it says should be the focus of research. (managedcaremag.com)
  • Committee on Comparative Effectiveness Research Prioritization. (freethesaurus.com)
  • Effectiveness trials, on the other hand, assess how well a particular intervention works compared with other options commonly used in clinical practice. (mayoclinic.org)
  • Effectiveness trials require substantially larger patient populations than placebo-controlled trials, which makes them far more costly and harder to recruit. (mayoclinic.org)
  • CER may be a systematic research review evaluating existing clinical trials, clinical studies, and other research. (nursingworld.org)
  • These clinical research trials measure the benefit produced by the treatment in routine clinical practice. (wikipedia.org)
  • Although they seek to demonstrate an intervention's effectiveness at a high level of statistical significance, randomized trials will always assign some patients to an inferior treatment and they will often assign patients to a treatment for which there is already partial evidence of its inferiority. (pnas.org)
  • The RE-ADAPT (REsearch in ADAptive methods for Pragmatic Trials) project was supported by the NHLBI (award 1RC4HL106363-01). (annals.org)
  • Others will point to the government's new paradigm for requiring significant industry sponsorship to fund their comparative effectiveness research (CER) trials as opening the potential for the development of "pay to play" relationships to develop between government and industry. (blogspot.com)
  • Clinical trials of cost-effectiveness of different strategies for initial treatment and maintenance therapy of acne are needed. (healthcanal.com)
  • The COMET (Core Outcome Measures in Effectiveness Trials) Initiative promotes the development and application of core outcome sets (COS), including relevant studies in an online database. (plos.org)
  • The COMET (Core Outcome Measures in Effectiveness Trials) Initiative ( www.comet-initiative.org ) promotes the development and application of COS, by including pertinent individual studies in a publically available online database. (plos.org)
  • How does the randomized controlled trials process fit in with comparative effectiveness research? (ascopost.com)
  • Randomized controlled clinical trials and meta-analyses of such trials are still the gold standard and backbone of comparative effectiveness research and the most definitive way to assess treatment efficacy. (ascopost.com)
  • The goal of comparative effectiveness research is to go beyond the boundaries of randomized trials and gather all the credible evidence on a given clinical question so that clinicians can make more rational choices in treatment selection. (ascopost.com)
  • it is a way to make the best use of comparative data, and randomized trials will always be a component in that process. (ascopost.com)
  • Eligible studies were randomized clinical trials (RCTs) and comparative cohort studies in adults that included two or more treatment options for GD. (pituitary.org)
  • However, much like the practice of medicine as a whole, many of our clinical decisions are not rooted in large comparative effectiveness trials. (asahq.org)
  • Despite the increasing uptake of electronic medical record (EMR) software in Primary Care, there has been little effort to date to utilize this software to conduct pragmatic comparative effectiveness research (CER) trials in Primary Care. (thewinnower.com)
  • Critically important clinical trials could not be conducted without the commitment of FORCE to the development and completion of cancer prevention, detection, treatment and quality of life research. (facingourrisk.org)
  • Prognosis research studies too often fall a long way short of the high standards required in other fields, such as therapeutic trials and genetic epidemiology. (bmj.com)
  • Journal of Comparative Effectiveness Research. (wikipedia.org)
  • The Journal of Comparative Effectiveness Research is a peer-reviewed medical journal that was established in 2012 and is published by Future Medicine. (wikipedia.org)
  • Three articles in the Journal of Comparative Effectiveness Research focus on the work and recommendations of a CER-centric conference convened last year by the PhRMA Foundation and the Academy of Managed Care Pharmacy. (healtheconomics.com)
  • Comparative effectiveness research adopts many of the same approaches and methodologies as cost-effectiveness analysis, including the use of incremental cost-effectiveness ratios (ICERs) and quality-adjusted life years (QALYs). (wikipedia.org)
  • Over time, the international agencies have begun to consider cost-effectiveness, as well as clinical effectiveness. (commonwealthfund.org)
  • Any mention of "comparative cost effectiveness" or value-based language is notably absent. (sciencebasedmedicine.org)
  • Although comparative clinical effectiveness research is distinct from comparative cost effectiveness research - it is likely that payers will use CCER to build their formularies. (sciencebasedmedicine.org)
  • Background England's National Institute for Health and Care Excellence (NICE) and the US' Institute for Clinical and Economic Review (ICER) both conduct cost-effectiveness evaluations for new cancer drugs to help payers make drug coverage decisions. (lse.ac.uk)
  • Methods We compared the methods and results of publicly available cost-effectiveness evaluations performed by ICER and NICE of similarly assessed cancer drugs. (lse.ac.uk)
  • Assessments were compared based on incremental cost-effectiveness ratio, comparator treatment, price, recommendation, and the design of the economic evaluation. (lse.ac.uk)
  • Findings Among 11 commonly assessed cancer drugs, ICER and NICE were in concordance for 7 evaluations and in discordance on the cost-effectiveness and coverage decisions for 4 drugs. (lse.ac.uk)
  • With the ongoing focus on healthcare outcomes-based payment models, pharmaceutical companies face powerful pressures to demonstrate not just safety and efficacy of a new treatment, but also both cost effectiveness and comparative effectiveness. (linguamatics.com)
  • And, "For now, Obama has stopped short of advocating coverage decisions that combine clinical finding with cost effectiveness. (honestmedicine.com)
  • We seek to understand the determinants of illness and well-being, and to improve the quality and cost-effectiveness of health care. (kaiserpermanente.org)
  • Gorst SL, Gargon E, Clarke M, Smith V, Williamson PR (2016) Choosing Important Health Outcomes for Comparative Effectiveness Research: An Updated Review and Identification of Gaps. (plos.org)
  • With Statista you are very public to know powerful parts and strengthen your book comparative effectiveness research in health services 2016 facility. (yanodan.com)
  • Information produced by comparative effectiveness research will be hard to use appropriately because context and emotion often dominate a patient's rational decisionmaking and because therapies are provided in different health care environments, making small differences between therapies basically meaningless. (rand.org)
  • The Institute for Clinical and Economic Review (ICER) on Tuesday announced plans to develop a review assessing the comparative clinical effectiveness and value of biologic therapies for moderate-to-severe asthma. (healtheconomics.com)
  • When applied to the implantation of cardiovascular resynchronization therapies to examine comparative survival, only 3 of 8 studies report arm-specific follow-up. (harvard.edu)
  • This lack of well-conducted research to test over-the-counter and prescription therapies is putting patients at risk of ineffective treatment and makes treatment decisions for patients and doctors very difficult. (healthcanal.com)
  • Professor Williams and his team are calling for new research into the comparative effectiveness of common topical and systemic therapies and to improve the understanding of the natural history, specific types, and triggers of acne, and how treatment affects the course of this poorly understood disease. (healthcanal.com)
  • By helping clinicians, patients, payers, and others to better distinguish between effective and ineffective (or potentially harmful) therapies, comparative effectiveness research (CER) has the potential to slow the growth of spending on healthcare without adversely affecting the quality of care. (hhs.gov)
  • The rich intellectual environment at Stanford, paired with our accessibility to the most advanced technology, is unmatched and ensures the rapid translation of pioneering laboratory research into life-saving clinical therapies for our patients. (stanford.edu)
  • From anti-cancer therapies and stem cell transplantation therapies for spinal cord injury to the elucidation of retinal neural circuitry and gene-environment interactions in fetal development, our research scientists are making quick progress tackling some of the most complex neurological disease questions in the neurodegenerative and neuroregenerative fields today. (stanford.edu)
  • Promising therapies are suggested by and explored with laboratory research, and some of these therapies, such as mild hypothermia, are then tested in the clinic. (stanford.edu)
  • We report numerical experiments that yield a heuristic approximation that applies even to very large horizons, and we propose a near-optimal strategy that remains valid even when the horizon is unknown or unbounded, thus applicable to comparative effectiveness studies on large populations or to standard-of-care recommendations. (pnas.org)
  • The first half of the chapter is a "portfolio analysis," which shows the representation of research areas, study populations, comparators, and study methodologies within the final 100 topics. (nap.edu)
  • Second, CER focuses on comparisons of alternative clinical approaches that have demonstrated efficacy in RCTs but may differ with respect to effectiveness in some populations, side effects, or costs. (hhs.gov)
  • and a school based care approach that examines the efficacy of school-based programs to impact asthma outcomes including effectiveness of linkages between schools and the healthcare providers. (biomedcentral.com)
  • To understand what CER is and anesthesiology's potential role, it is essential to have a basic understanding of the concepts of efficacy, effectiveness, and efficiency. (asahq.org)
  • In this multicenter, randomized, controlled, double-blind, double-dummy clinical trial, in which we will use the comparative effectiveness research method, we will compare the efficacy of two commonly used Chinese patent medicines for angina patients diagnosed with qi deficiency and blood stasis syndrome. (biomedcentral.com)
  • For example, this type of research could be used to economically compare the efficacy of pharmaceutical classes with many similar options (known as "me too" drugs). (thewinnower.com)
  • The six statin medications currently on the market in Canada are an exemplar for this study as comparative efficacy data, especially on patient-centred outcomes is either non-existent or not publicly available. (thewinnower.com)
  • The Harvard Pilgrim team includes experts in data standards, data security and privacy, medical ethics, patient-reported outcomes, project management, and research communications and dissemination. (healthcareitnews.com)
  • Dissemination and Adoption of Comparative Effectiveness Research Findings When Findings Challenge Current Practices. (hhs.gov)
  • Recognizing this fact, a sizable portion of the ARRA funding was devoted to research on the dissemination and implementation of CER. (hhs.gov)
  • The development process extended from July to December 2011, and included examination of other recent prioritization efforts and input received through discussions with stakeholder groups, including patients and their caregivers, clinicians, hospitals and health care systems, payers, the life sciences industry, and the research community. (medindia.net)
  • The Comparative Effectiveness Research - Coordination and Implementation Team (CER-CIT) will require the use of the Federal Coordinating Council's prioritization criteria for scientifically meritorious research and investments for all projects funded with OS ARRA funds. (nih.gov)
  • The government's new CCER initiative will be administered through a Federal Coordinating Council for clinical comparative effectiveness research. (sciencebasedmedicine.org)
  • The same criticism applies for the members of the Federal Coordinating Council for Comparative Effectiveness Research that was recently named by HHS. (honestmedicine.com)
  • The Federal Coordinating Council for Comparative Effectiveness Research used similar terms to define CER ( Federal Coordinating Council for Comparative Effectiveness Research, 2009 ). (hhs.gov)
  • This review article explores the Medicare data available for researchers and approaches that could be used to enhance the data%u2019s value for comparative effectiveness research. (ajmc.com)
  • A type of health care research that compares the results of one approach for managing a disease to the results of other approaches. (sciencebasedmedicine.org)
  • In addition to traditional health sciences methods, modern approaches to comparative effectiveness research now include greater emphasis on social sciences frameworks such as economics, ethics, and implementation science. (springer.com)
  • Country-specific examples include an overview chapter on national approaches from various countries in Europe, Australia, and Canada, as well as specific chapters on comparative effectiveness research in Brazil and in the United States. (springer.com)
  • Recognizing the challenges to conducting valid retrospective epidemiologic and health services research studies, a Task Force was formed to develop a guidance document on state of the art approaches to frame research questions and report findings for these studies. (ispor.org)
  • Prognosis research findings should thus be integral to clinical decision making, healthcare policy, and discovering and evaluating new approaches to patient management. (bmj.com)
  • I]nnumerable practical decisions facing patients and doctors every day do not rest on a solid foundation of knowledge about what constitutes the best choice of care," says the committee report, Initial National Priorities for Comparative Effectiveness Research. (managedcaremag.com)
  • Provide ideas for research topics -- to help us decide which research studies to support. (arthritis.org)
  • The evidence is generated from research studies that compare drugs, medical devices, tests, surgeries, or ways to deliver health care. (nursingworld.org)
  • This CER Systematic Reviews search strategy was developed to identify secondary research such as systematic reviews, meta-analyses, mathematical models, simulations and related studies in PubMed. (nih.gov)
  • The HSRProj search strategy includes Program Evaluation studies in addition to health services research studies focusing on CER. (nih.gov)
  • Beginning with 4 of proof-of-concept retrospective CER studies on psychotropic and asthma medication use and side effects with a planned full-scale prospective CER study on treatment of pediatric hypertension, the Comparative Effectiveness Research Through Collaborative Electronic Reporting (CER 2 ) collaborators are developing a platform to advance the methodology of pediatric pharmacoepidemiology. (aappublications.org)
  • While there remains a widespread lack of understanding on the potential impact of CER in the U.S. and a reluctance to fully adopt the concept as part of our healthcare system, research studies within this area continue to expand across health conditions. (wikipedia.org)
  • The international agencies rely mainly on syntheses of existing studies, rather than prospective research, owing to time and resource constraints. (commonwealthfund.org)
  • Conclusions: In this sample of studies examining high priority areas for CE research, less than a quarter are CE studies and the majority is supported by government and nonprofits. (harvard.edu)
  • Hywel Williams, Professor of Dermato-Epidemiology and Director of the CEBD said: "The large number of products and product combinations, and the scarcity of comparative studies, has led to disparate guidelines with few recommendations being evidence-based. (healthcanal.com)
  • One important element of CER is to ensure that appropriate outcomes are measured in research, so that findings can be compared and contrasted across different studies, and useful evidence can be provided to decision makers. (plos.org)
  • Similarly, the priority research topics include studies examining various special population categories, including individuals with rare diseases. (nap.edu)
  • Distributed health data networks are currently being planned that could cover millions of people, permitting studies of comparative clinical effectiveness, best practices, diffusion of medical technologies, and quality of care. (annals.org)
  • Berger ML, Mamdani M, Atkins D, Johnson ML. Good research practices for comparative effectiveness research: defining, reporting and interpreting nonrandomized studies of treatment effects using secondary data sources: The ISPOR good research practices for retrospective database analysis task force report-Part I. Value Health 2009;12:1044-52. (ispor.org)
  • Conclusions: Comparative effectiveness research in the form of nonrandomized studies using secondary databases can be designed with rigorous elements and conducted with sophisticated statistical methods to improve causal inference of treatment effects. (ispor.org)
  • Read highlights of our funded research studies' results that are being published in leading medical journals and presented at major scientific meetings. (pcori.org)
  • Randomized and non-randomized treatment effectiveness studies frequently include analyses to identify subgroups in which the treatment may be more or less effective. (upenn.edu)
  • noteworthy book comparative effectiveness research increases the homepage of a insight to boast studies that would sign the study's chaplaincy. (yanodan.com)
  • The purpose of this study was to develop a self-reflective framework to guide clinicians, researchers, and technical implementers in developing prospective CER research studies in Primary Care, and overcoming barriers to implementation and use. (thewinnower.com)
  • This framework is intended to be used to develop large-scale, long-term, pragmatic comparative effectiveness studies in Family Practice in Canada. (thewinnower.com)
  • Everything we understand about cancer reflects the results of thousands of research studies that provide the answers we need to make informed medical decisions. (facingourrisk.org)
  • The vast majority of previous CER consists of systematic reviews of published research studies. (hhs.gov)
  • We have comparative effectiveness studies out the wazoo on this issue alone and they would be too numerous to mention here. (blogspot.com)
  • In the absence of RCTs, evidence generation will require well-designed cohort studies for comparative effectiveness research (CER) that link detailed clinical information to tumor biology and genomic data. (blogspot.com)
  • Results of its research will be provided to patients and clinicians in ways that are responsive to their needs and interests and easy to understand. (nursingworld.org)
  • The Distributed Ambulatory Research in Therapeutics Network (DARTNet) is a federated network of electronic health data from 8 organizations representing more than 500 clinicians and more than 400 000 patients. (nih.gov)
  • The proposition that greater involvement of patients, clinicians, and others in the research process could help reorient the clinical research enterprise, reduce clinical uncertainty, and speed adoption of meaningful findings holds great promise, but remains to be tested. (medindia.net)
  • In this talk Dr Sanders will describe the overall research agenda of the U.S. Effective Healthcare Program which funds individual researchers, research centers, and academic organizations to work together with Agency for Healthcare Research and Quality (AHRQ) to produce effectiveness and comparative effectiveness research for clinicians, consumers, and policymakers. (warwick.ac.uk)
  • It's especially important for comparative effectiveness research because this research is meant primarily to serve patients and their clinicians. (healthjournalism.org)
  • The meeting discussions were formulated into five recommendations for researchers, clinicians, and other stakeholders to advance research on how clinical treatment options may influence long-term cognitive decline. (biomedcentral.com)
  • The United States lacks a system to use routinely collected electronic health record (EHR) clinical data to conduct comparative effectiveness research (CER) on pediatric drug therapeutics and other child health topics. (aappublications.org)
  • The National Institutes of Health (NIH) announces the opportunity for investigators and United States (U.S.) institutions/organizations with active NIH research grants to request administrative supplements for the purpose of expanding the numbers of researchers qualified to oversee or conduct comparative effectiveness research (CER). (nih.gov)
  • In this dissertation, I develop statistical methods for comparative effectiveness estimation and illustrate the methodology in the context of three different medical devices. (harvard.edu)
  • The simple definition of comparative effectiveness research is: a methodology that attempts to frame the delivery of health care by comparing the benefit and harm of available diagnostic, prognostic, and therapeutic strategies in representative patients to define the most effective, safe, and cost-effective approach. (ascopost.com)
  • Research plan and methodology The investigators hypothesize that rectal administration of indomethacin is not inferior to placement of a pancreatic duct stent in the prevention of pancreatitis after ERCP in high risk patients. (centerwatch.com)
  • Following the proposed research, designs for CER should be done while abiding by robust methodology, maintaining transparency, and effectively translating research into clinical practice. (elsevier.com)
  • Background: The $1.1 billion investment in comparative effectiveness research will reshape the evidence-base supporting decisions about treatment effectiveness, safety, and cost. (harvard.edu)
  • Participate in a research study - such as an online or in-person focus group. (arthritis.org)
  • The 2009 American Recovery and Reinvestment Act designated $400 million in discretionary funds to accelerate CER efforts, and among other areas of study, the Institute of Medicine prioritized research comparing different strategies of introducing biologics in the treatment algorithm for inflammatory bowel disease (IBD). (mayoclinic.org)
  • Arguably the most well-known IBD effectiveness study is the landmark SONIC trial, which compared early use of infliximab plus azathioprine to monotherapy with either drug in patients naive to corticosteroids, immunomodulators and anti-tumor necrosis factor (anti-TNF) agents. (mayoclinic.org)
  • The study of comparative effectiveness research (CER) is composed of measures useful in determining the value of various treatment options to help patients make more informed decisions in their own care. (wikipedia.org)
  • Our ultimate goals are to develop upon what is known in the literature and identify areas where additional measures will improve the ability to study the effectiveness and safety of antidepressants in the primary care environment. (aafp.org)
  • Comparative Safety Study of Antidepressants-Measure rates of adverse effects to include the most common medical side effects causing treatment discontinuation, and suicidality, including ideation and attempts. (aafp.org)
  • Enhancing Electronic Health Record Measurement of Depression Severity and Suicide Ideation: A Distributed Ambulatory Research in Therapeutics Network (DARTNet) Study. (aafp.org)
  • The authors drew on their experience as senior technical and administrative staff involved in creating and running comparative effectiveness research agencies in the four countries included in this study. (commonwealthfund.org)
  • The study states: "To ensure research activities that truly embrace the definition of CER, the ARRA funds - and subsequent funding to support CER - should flow through a CER coordinating authority directly to grantees, through federal agencies, or both. (managedcaremag.com)
  • This newly-approved study, titled "The comparative effectiveness and safety of antidepressants for the treatment of depression in nursing home residents", will apply methods from comparative effectiveness research , pharmacoepidemiology , and biomedical informatics. (pitt.edu)
  • This article presents an overview of DARTNet, explains the contributions of DARTNet to the field of comparative effectiveness research, and summarizes the initial research study and lessons learned. (annals.org)
  • EHR use in pharmacotherapy comparative effectiveness research creates specific challenges and study limitations. (rti.org)
  • A centralized database will be created with the goal of facilitating comparative effectiveness research on asthma outcomes specifically for this study. (biomedcentral.com)
  • The purpose of this study was to assess the comparative effectiveness of allopurinol versus febuxostat for preventing incident dementia in older adults. (biomedcentral.com)
  • In ALI, CD4-positive to these preferences is the particular methods in comparative of differentiation cells allowed in the vomiting, study, and proliferation of crucial and crucial navigation getting to infected dependent assassination. (thw-huenfeld.de)
  • ObjectiveThe ENGAGE CVD (Effectiveness of Gastric Bypass versus Gastric Sleeve for Cardiovascular Disease) cohort study aimed to provide population-based, comprehensive, rigorous evidence for clinical and policy decision making regarding the choice between gastric bypass and gastric sleeve for overall cardiovascular disease (CVD) risk reduction, risk factor remission, and safety. (doaj.org)
  • Although this type of research is overall more cost-effective, there are significant upfront costs in creating the initial study infrastructure that private vendors are unlikely to bear themselves. (thewinnower.com)
  • The Depression Clinical & Research Program (DCRP) at Massachusetts General Hospital is considered one of the leading centers for the study of unipolar depressive disorders worldwide. (massgeneral.org)
  • The Depression Clinical and Research Program (DCRP), under the direction of David Mischoulon, MD, PhD , is a leader worldwide in the study of unipolar depressive disorders. (massgeneral.org)
  • You may be eligible to participate in a research study at Mass General. (massgeneral.org)
  • The objective of this study was to compare the effectiveness of vancomycin and linezolid in a national cohort of hospitalized veterans with HCAP. (biomedcentral.com)
  • This study was approved by the Institutional Review Board of The University of Texas Health Science Center at San Antonio and the South Texas Veterans Health Care System Research and Development committee. (biomedcentral.com)
  • In our real-world comparative effectiveness study among obese patients with suspected MRSA pneumonia, linezolid was associated with a significantly lower mortality rate as compared to the vancomycin-treated patients with lower vancomycin MICs. (omicsonline.org)
  • State public health programs could screen nearly eight times as many individuals and prevent nearly twice as many CRC cases by using fecal immunochemical testing, or FIT, instead of colonoscopies, finds a new study in Health Services Research . (cfah.org)
  • Neurosurgery scientists also study the presence and roles of stem-like cells in brain tumors, research that is already suggesting ways to inhibit brain tumor growth and destroy tumors. (stanford.edu)
  • and pursue transparency in our research engagements through our commitment to the open publication of our research findings and recommendations, disclosure of the source of funding of published research, and policies to ensure intellectual independence. (rand.org)
  • The money has primarily funded research and helped facilitate getting findings to the patients, doctors, and others who can use them. (gao.gov)
  • This Report, the first of three reported in this issue of the journal, addressed issues of framing the research question and reporting and interpreting findings. (ispor.org)
  • Comparative effectiveness usually compares two or more types of treatment, such as different drugs, for the same disease. (sciencebasedmedicine.org)
  • Critics of research that ultimately compares an outcome based on a better average value in an intervention group compared to an average value in the comparison group have a point. (blogspot.com)
  • It will commission research to provide information about the best available evidence to help patients and their health care providers make more informed decisions. (nursingworld.org)
  • By linking electronic health records, laboratory and imaging data, and administrative data from diverse and geographically disparate patients, DARTNet provides important new insight into the comparative effectiveness of oral diabetes medications, and it is ready for expansion to further enable effectiveness research. (nih.gov)
  • New models of shared decision making promise to bring greater emphasis to informed patient choice for "preference-sensitive" care, improving quality, safety, and effectiveness of health care by providing both patients and their health care providers with the evidence to assist in informed decision making. (wikipedia.org)
  • The institute's first funding announcement solicited projects focused on methods for engaging patients and other stakeholders in all aspects of the research process," Dr. Beal and colleagues write. (medindia.net)
  • Applicants will be instructed to explain how their proposed research aligns with the statutory criteria and to describe how patients and other stakeholders will be engaged in and benefit from the research. (medindia.net)
  • This research can help patients, doctors, and others make decisions to improve health care. (gao.gov)
  • In Australia, France, Germany, and the U.K., comparative effectiveness research is driven by demand for information by those making health care policy and practice decisions, including public and private payers, patients, clinical professionals, and policymakers. (commonwealthfund.org)
  • HDBuzz is a patient organization that exists solely to provide news stories about clinical and basic research in the HD field for HD patients and those at risk for HD. (cfah.org)
  • The Company's novel pipeline is based on Nobel Prize winning research and includes four differentiated investigational drug candidates: TRV250 for the acute treatment of migraine, TRV734 for maintenance treatment of opioid use disorder, TRV045 for diabetic neuropathic pain and epilepsy, and TRV027 for acute respiratory distress syndrome and abnormal blood clotting in COVID-19 patients. (biospace.com)
  • But do we know which subset of patients each one of those is best suited to, and what is the differential effectiveness? (managedcaremag.com)
  • The Institute for Clinical and Economic Review (ICER) on Monday announced its plans to analyze the comparative clinical effectiveness and value of Novartis' canakinumab to reduce cardiovascular risk in patients diagnosed with atherosclerosis. (healtheconomics.com)
  • While this will certainly delay enrollment of patients into this trial, it also serves as a harbinger for the penurious nature of future government funding for comparative effectiveness research. (blogspot.com)
  • Health-care policy experts have made a strong case that comparative effectiveness research is an important instrument for comparing the value of competing strategies so that patients, providers, and policy makers can be offered appropriate recommendations for optimal care. (ascopost.com)
  • Purpose - Little is known about the comparative effects of common oral antidiabetic drugs ([OADs] metformin, sulfonylureas, or thiazolidinediones [THZs]) on chronic kidney disease (CKD) outcomes in patients newly diagnosed with type 2 diabetes (T2DM) and followed in community primary care practices. (rti.org)
  • Objectives: Health insurers, physicians, and patients worldwide need information on the comparative effectiveness and safety of prescription drugs in routine care. (ispor.org)
  • Clinical research is based on the clustering of detectable patient outcomes around the mean, while smaller numbers of patients in both groups may get a lot better or worse. (blogspot.com)
  • All of these arguments are reduced to mere chatter, though, if comparative effectiveness research doesn't result in physicians altering how they treat their individual patients. (freethesaurus.com)
  • Some registries also allow researchers to contact and inform enrolled patients of new research opportunities. (facingourrisk.org)
  • Methicillin-Resistant Staphylococcus aureus (MRSA) has become a leading cause of pneumonia in the United States and there is limited data on treatment outcomes in obese patients.We evaluated the effectiveness of linezolid compared to vancomycin for the treatment of MRSA pneumonia in a national cohort of obese Veterans. (omicsonline.org)
  • The purpose of the Agency is to enhance the quality, appropriateness, and effectiveness of health services, and access to such services, through the establishment of a broad base of scientific research and through the promotion of improvements in clinical and health system practices, including the prevention of diseases and other health conditions. (house.gov)
  • And, although our research themes vary from lab to lab, they are all focused on aspects of disease and injury that can be investigated at the bench - and they all have clear implications for practices in the clinic and operating room. (stanford.edu)
  • While Australia, France, Germany, and the U.K. have developed comparative effectiveness research agencies to suit their unique circumstances, the four agencies share common features that should be carefully considered by U.S. policymakers. (commonwealthfund.org)
  • This Special Article describes the creation and details of a network of EHR networks devised to use clinical data in EHRs for conducting CER, led by the American Academy of Pediatrics Pediatric Research in Office Settings (PROS). (aappublications.org)
  • Approximately $106 million in commitments to date are for PCORnet, a data research network aimed at improving the capacity for and speed of conducting CER. (gao.gov)
  • Comparative Effectiveness of Treatment for Major Depression-Utilize commercially available national claims data to evaluate the responsiveness and remission rates for major depression treatment and inform and expand knowledge on depression care. (aafp.org)
  • and coordinate with relevant federal health programs to build data capacity for this research. (gao.gov)
  • The research will mainly be based on data from Swedish population and health data registers. (ki.se)
  • In other words, are we mature enough to use comparative effectiveness data to make tough decisions about what we will and won't pay for? (thehealthcareblog.com)
  • The research network coordinating this project includes hospitals, urgent care centers, and outpatient clinics within Carolinas Healthcare System that share a common electronic medical record and billing system allowing for rapid collection of clinical and demographic data. (biomedcentral.com)
  • In this paper we describe lessons learned from the creation of Basic Stand Alone (BSA) Public Use Files (PUFs) for the Comparative Effectiveness Research Public Use Files Data Pilot Project (CER-PUF). (uni-muenchen.de)
  • A three-year $10.5 million federal grant awarded in December to help speed up mental health research will rely heavily on data from members of six Kaiser Permanente regions, including Kaiser Permanente Northern California. (kaiserpermanente.org)
  • Additionally, some health conditions, such as for prostate cancer treatment, lack patient-centered outcomes to inform comparative effectiveness research. (wikipedia.org)
  • Other countries' experiences in creating and operating comparative effectiveness research agencies may provide useful lessons to inform these discussions. (commonwealthfund.org)
  • The Agency for Healthcare Research and Quality funded the creation of DARTNet through its Developing Evidence to Inform Decisions about Effectiveness Network. (annals.org)
  • Comparative effectiveness research (CER) informs health-care decisions by providing evidence on the effectiveness, benefits, and harms of different treatment options. (nursingworld.org)
  • The core question of comparative effectiveness research is which treatment works best, for whom, and under what circumstances. (wikipedia.org)
  • The idea of CER is that researchers and scientists gather evidence and compare surgeries, medical devices, drugs, tests, or health care services, and weigh the effectiveness, benefits, and potential harms of each of these treatment options against one another. (scai.org)
  • Compare the effectiveness of treatment strategies for atrial fibrillation including surgery, catheter ablation, and pharmacologic treatment. (managedcaremag.com)
  • The focus on the individual patient is described through chapters on patient-centred comparative effectiveness research, individualized treatment, the link with personalized medicine, and incorporating patient and public input for treatment. (springer.com)
  • What we would like to see is a great deal more comparative effectiveness research to help reduce the plethora of current therapeutic options for initiation and maintenance treatment. (healthcanal.com)
  • Many in the oncology community initially viewed comparative effectiveness research as an overarching government program that would ultimately ration oncologists' treatment options in order to save money. (ascopost.com)
  • A direct comparison in the form of a RCT to compare effectiveness of both treatment modalities is required. (centerwatch.com)
  • One will provide up to $16 million for research on the best ways to deliver medication-assisted treatment for opioid use disorders to pregnant women. (pcori.org)
  • Effectiveness refers to the actual benefit of that treatment in usual care settings in a broad patient population. (asahq.org)
  • Every advancement made in treatment, prevention or care has come from research. (facingourrisk.org)
  • Fox RJ a Mellen Center for Multiple Sclerosis Treatment and Research , Cleveland Clinic , Cleveland , OH , USA. (unboundmedicine.com)
  • As part of his training, he is conducting research to compare the effectiveness and safety of antidepressants used to treat elderly adults residing in nursing homes. (pitt.edu)
  • The goal of this network is to engage child health researchers from around the United States in participating in collaborative research using the CER 2 database. (aappublications.org)
  • By Janet Byron, Senior Communications Specialist, Kaiser Permanente Division of Research In a new video, Kaiser Permanente researchers explain how the Walnut Creek ophthalmology department virtually eliminated a rare, surgery-related infection. (kaiserpermanente.org)
  • Participants included researchers with an interest in Primary Care research, technical representatives of EMR vendors, and Family Physicians. (thewinnower.com)
  • In the future, researchers will need to clearly outline the business case for vendors to participate in Primary Care research. (thewinnower.com)
  • Such a process was long thought to be absent in the brain, but research in the last decade, much of it by Stanford Neurosurgery researchers, has shown neurogenesis to be robust and important to brain function and perhaps to the repair of the brain after injury. (stanford.edu)
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  • The goal of comparative effectiveness research is to improve health care while dealing with the seemingly ever-rising cost. (ajnr.org)
  • The Institute for Clinical and Economic Review (ICER) will assess the comparative clinical effectiveness and value of elagolix (AbbVie) for management of endometriosis with associated pain. (healtheconomics.com)
  • This type of research is intended to foster evidence-based changes in practice that reduce costs and improve patient care. (mayoclinic.org)
  • She will specifically focus on the comparative effectiveness research (CER) taking place at Duke University as part of the Evidence-based Practice Center. (warwick.ac.uk)
  • They are optimistic it will, because there are some examples of the rapid translation of clinical research into mainstream practice. (blogspot.com)
  • Understanding and improving the prognosis of a disease or health condition is a priority in clinical research and practice. (bmj.com)
  • The DCRP's research has informed clinical practice and contributed to the development of new standards of care for depression. (massgeneral.org)
  • This work aims to: (1) develop and refine topics for CERs that are informative to stakeholder decisional needs, (2) conduct CERs with systematic and transparent methods, and to (3) identify and explicate future research needs that are important to answering real-world healthcare decisions. (warwick.ac.uk)
  • In the four countries, comparative effectiveness research agencies produce information that affects clinical and health policy decisions. (commonwealthfund.org)
  • Blue Cross Blue Shield Association Chief Medical Office Trent Haywood discussed comparative effectiveness research and how it could facilitate personalized decisions on health care. (healtheconomics.com)
  • After a prolonged debate over government-sponsored comparative effectiveness research, Congress decided to authorize it in the Affordable Care Act, but to strictly forbid CMS from considering the results in coverage decisions. (physicianspractice.com)
  • NICE provides an important reminder of how much lower other countries pay for drugs when comparative effectiveness and value-based pricing are integrated into public drug coverage decisions. (lse.ac.uk)
  • As more people participate in research, scientists and health care providers can develop new evidence-based guidelines to help people make health care decisions. (facingourrisk.org)
  • DARTNet was designed to increase knowledge of the comparative effectiveness of prescription medications and medical devices. (nih.gov)
  • Key clinical information traditionally missing in comparative effectiveness research is now available through DARTNet. (annals.org)
  • The RAND Corporation is a research organization that develops solutions to public policy challenges to help make communities throughout the world safer and more secure, healthier and more prosperous. (rand.org)
  • Medical devices bring a unique set of challenges for comparative effectiveness research. (harvard.edu)
  • However, while acceptance of comparative effectiveness research is growing, operational as well as political and cultural challenges remain. (ascopost.com)
  • Multiple Imputation for Disclosure Limitation: Future Research Challenges. (uni-muenchen.de)
  • Special series on comparative effectiveness research: challenges to real-world solutions to quality improvement in personalized medicine. (blogspot.com)
  • The National Institute for Health and Clinical Excellence of the United Kingdom is a noteworthy example of comparative effectiveness research in action. (ajnr.org)
  • The Institute for Clinical and Economic Review recently released a Draft Evidence Report assessing the comparative clinical effectiveness and value of emicizumab. (healtheconomics.com)
  • This has prompted the Institute of Medicine in the USA to target comparative-effectiveness research on acne therapy as one of the top 100 targets for national research. (healthcanal.com)
  • This work was funded by the NIHR (National Institute for Health Research), grant number NF-SI_0513-10025. (plos.org)
  • As explained in detail in Chapter 1 , the Institute of Medicine (IOM) committee's statement of task charged the committee with developing a list of priority comparative effectiveness research (CER) topics and presenting those recommendations for the Secretary to consider. (nap.edu)
  • Also according to the Washington Post article, "Experts at the Institute of Medicine will spend the next several months prioritizing the research. (honestmedicine.com)
  • The directors of the Coordinating Center will be Richard Platt, MD, professor and chair of the Harvard Medical School Department of Population Medicine at the Harvard Pilgrim Health Care Institute in Boston, and Robert Califf, MD, vice chancellor for clinical and translational research, director of the Duke Translational Medicine Institute, and professor of Medicine in the Division of Cardiology at the Duke University Medical Center in Durham, N.C. (healthcareitnews.com)
  • Additional expertise is provided by staff from AcademyHealth, Brookings Institution, Center for Democracy and Technology, Center for Medical Technology Policy, Group Health Research Institute and Johns Hopkins University . (healthcareitnews.com)
  • The California Institute for Regenerative Medicine hosts Dr. Gary Steinberg in an 'Ask the Expert' Facebook Live event about his clinical research on the use of stem cell therapy for stroke. (stanford.edu)
  • These funds are divided among the National Institutes of Health, Department of Health and Human Services, and Agency for Healthcare Research and Quality. (asahq.org)
  • He is a member of the National Institutes of Health's Comparative Effectiveness Research Steering Committee and was a previous vice chair of the Medicare Evidence Development and Coverage Advisory Committee. (freethesaurus.com)
  • It has a history of managing and coordinating similar initiatives, including the U.S. Food and Drug Administration's Mini Sentinel Program and the National Institutes of Health's Health Care Systems Research Collaboratory. (healthcareitnews.com)
  • 1 billion in funding for CER, channeled through the National Institutes of Health (NIH), the Department of Health and Human Services (HHS), and the Agency for Healthcare Research and Quality (AHRQ). (hhs.gov)
  • This group will oversee the application of comparative effectiveness research in health care reform. (medicallessons.net)
  • This follows the region-wide adoption of an integrated telemedicine program, according to new research published December 15 in the journal Stroke. (kaiserpermanente.org)
  • The editors-in-chief are Sheldon Greenfield (University of California, Irvine) and Eugene Rich (Mathematica Policy Research). (wikipedia.org)
  • The Costs and Cost Analysis search strategy is based on the Health Services Research query on Costs (Broad scope). (nih.gov)
  • The Comparative Effectiveness Research as Topic search strategy has been designed to retrieve citations "about" CER. (nih.gov)
  • In 2013, the first comprehensive search for COS in health research was conducted to ensure that the database content was comprehensive and up-to-date [ 4 ]. (plos.org)
  • The Kaiser Permanente Division of Research conducts, publishes, and disseminates epidemiologic and health services research to improve the health and medical care of Kaiser Permanente members and society at large. (kaiserpermanente.org)
  • It provides general guidance and suggestions for engagement compliance and engagement strategies in the research process. (pcori.org)
  • The Alzheimer's Drug Discovery Foundation convened an advisory panel to discuss the existing evidence and to recommend strategies to accelerate the development of comparative effectiveness research on how choices in the clinical care of common chronic diseases may protect from cognitive decline and dementia. (biomedcentral.com)
  • Comparative analysis of proposed strategies for incorporating biologic factors into breast cancer staging. (utmb.edu)
  • Remove constraint Titles: Comparative effectiveness: what's at stake for consumers? (nih.gov)
  • This is methods in comparative effectiveness subset( from the Latin for eosinophil correlation). (thw-huenfeld.de)
  • What this means," says I. Steven Udvarhelyi, MD, senior vice president and chief medical officer at Independence Blue Cross, "is that the experts that sat on the panel with me looking at the available research said that we do not have enough information that tells us the relative effectiveness. (managedcaremag.com)
  • Comparative effectiveness also can compare types of surgery or other kinds of medical procedures and tests. (sciencebasedmedicine.org)
  • The National Pharmaceutical Council (NPC) is a health policy research organization dedicated to the advancement of good evidence and science, and to fostering an environment in the United States that supports medical innovation. (npcnow.org)
  • Participating in research allows people to contribute to medical knowledge and offers the opportunity to receive cutting-edge care. (facingourrisk.org)
  • Experts design and conduct many different types of medical research to answer different types of questions. (facingourrisk.org)
  • Make the best use of Scientific Research and information from our 700+ peer reviewed, Open Access Journals that operates with the help of 50,000+ Editorial Board Members and esteemed reviewers and 1000+ Scientific associations in Medical, Clinical, Pharmaceutical, Engineering, Technology and Management Fields. (omicsonline.org)
  • As the number of patient centered medical homes has increased, a new report in the journal Health Services Research finds the model offers a promising option to reduce health care costs and utilization of some health care services. (cfah.org)
  • This research recognizes that the patient's voice should be heard in the health care decision making process. (nursingworld.org)
  • AHRQ is dedicated to improving the quality, safety, efficiency, and effectiveness of health care for all Americans. (nursingworld.org)
  • The Agency for Healthcare Research and Quality (AHRQ) is a federal agency focused on health care quality. (wikipedia.org)
  • By contrast, comparative effectiveness legislation under consideration in the U.S. Senate explicitly separates the generation of knowledge from health care decision-making. (commonwealthfund.org)
  • Gruman: Where do you see comparative effectiveness research (CER) fitting in the effort to improve the effectiveness of health care? (cfah.org)
  • First off, it is important to note that comparative effectiveness research has been applied across the spectrum of cancer needs from prevention, screening, diagnosis, all the way through supportive care and end-of-life issues. (ascopost.com)
  • Linking cost savings with the central mission of comparative effectiveness research has perhaps given the impression to many in the oncology community that they are going to be overly scrutinized about the costs of the care they deliver. (ascopost.com)
  • Skinner, J.A., Weinstein, M.C. "Comparative Effectiveness and Health Care Spending - Implications for Reform. (investigatorawards.org)
  • The Disease Management Care Blog found three predictable articles on comparative effectiveness research (CER) in the latest [May 17 Volume 360 (19)] New England Journal of Medicine . (blogspot.com)
  • Background: Comparative effectiveness research (CER) has come to remain at the forefront of political and scientific debates of health care. (elsevier.com)
  • There are currently multiple barriers to conducting EMR-enabled research in Primary Care. (thewinnower.com)
  • While this has resulted in improved clinical efficiencies and patient care [Canada Health Infoway (2013)], unfortunately these improvements have not been paralleled in the realm of Primary Care research. (thewinnower.com)
  • The clinical program delivers care outside of the research setting to people with depressive disorders. (massgeneral.org)
  • Comparative effectiveness research, genomics-enabled personalized medicine, and rapid learning health care: a common bond. (blogspot.com)