Comparative Effectiveness Research: Conduct and synthesis of systematic research comparing interventions and strategies to prevent, diagnose, treat, and monitor health conditions. The purpose of this research is to inform patients, providers, and decision-makers, responding to their expressed needs, about which interventions are most effective for which patients under specific circumstances. (hhs.gov/recovery/programs/cer/draftdefinition.html accessed 6/12/2009)Matched-Pair Analysis: A type of analysis in which subjects in a study group and a comparison group are made comparable with respect to extraneous factors by individually pairing study subjects with the comparison group subjects (e.g., age-matched controls).United States Agency for Healthcare Research and Quality: An agency of the PUBLIC HEALTH SERVICE established in 1990 to "provide indexing, abstracting, translating, publishing, and other services leading to a more effective and timely dissemination of information on research, demonstration projects, and evaluations with respect to health care to public and private entities and individuals engaged in the improvement of health care delivery..." It supersedes the National Center for Health Services Research. The United States Agency for Health Care Policy and Research was renamed Agency for Healthcare Research and Quality (AHRQ) under the Healthcare Research and Quality Act of 1999.United StatesTreatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.American Recovery and Reinvestment Act: Public Law No: 111-5, enacted February 2009, makes supplemental appropriations for job preservation and creation, infrastructure investment, energy efficiency and science, assistance to the unemployed, and State and local fiscal stabilization, for fiscal year ending September 30, 2009.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Outcome Assessment (Health Care): Research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome. Measures include parameters such as improved health, lowered morbidity or mortality, and improvement of abnormal states (such as elevated blood pressure).Decision Making: The process of making a selective intellectual judgment when presented with several complex alternatives consisting of several variables, and usually defining a course of action or an idea.Patient Outcome AssessmentPatient-Centered Care: Design of patient care wherein institutional resources and personnel are organized around patients rather than around specialized departments. (From Hospitals 1993 Feb 5;67(3):14)Cost-Benefit Analysis: A method of comparing the cost of a program with its expected benefits in dollars (or other currency). The benefit-to-cost ratio is a measure of total return expected per unit of money spent. This analysis generally excludes consideration of factors that are not measured ultimately in economic terms. Cost effectiveness compares alternative ways to achieve a specific set of results.Quality-Adjusted Life Years: A measurement index derived from a modification of standard life-table procedures and designed to take account of the quality as well as the duration of survival. This index can be used in assessing the outcome of health care procedures or services. (BIOETHICS Thesaurus, 1994)Evidence-Based Medicine: An approach of practicing medicine with the goal to improve and evaluate patient care. It requires the judicious integration of best research evidence with the patient's values to make decisions about medical care. This method is to help physicians make proper diagnosis, devise best testing plan, choose best treatment and methods of disease prevention, as well as develop guidelines for large groups of patients with the same disease. (from JAMA 296 (9), 2006)Evidence-Based Practice: A way of providing health care that is guided by a thoughtful integration of the best available scientific knowledge with clinical expertise. This approach allows the practitioner to critically assess research data, clinical guidelines, and other information resources in order to correctly identify the clinical problem, apply the most high-quality intervention, and re-evaluate the outcome for future improvement.Financial Support: The provision of monetary resources including money or capital and credit; obtaining or furnishing money or capital for a purchase or enterprise and the funds so obtained. (From Random House Unabridged Dictionary, 2d ed.)Tobacco Industry: The aggregate business enterprise of agriculture, manufacture, and distribution related to tobacco and tobacco-derived products.FloridaDiabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.Diabetes Mellitus: A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.

The policies and politics of creating a comparative clinical effectiveness research center. (1/390)

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'Marginal medicine': targeting comparative effectiveness research to reduce waste. (2/390)

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Developing a policy for second-generation antipsychotic drugs. (3/390)

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Comparative effectiveness research for antipsychotic medications: how much is enough? (4/390)

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Does telemonitoring of patients--the eICU--improve intensive care? (5/390)

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Measurement of and reward for efficiency In California's pay-for-performance program. (6/390)

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Is it time to reexamine the patent system's role in spending growth? (7/390)

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Gemcitabine for the treatment of metastatic breast cancer. (8/390)

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  • PCORI claims its research is intended to give patients a better understanding of the prevention, treatment and care options available. (judicialwatch.org)
  • The PPACA further set forth that the PCORI should focus on Comparative Effectiveness Research in existing clusters or subgroups of the population that are underserved or unrepresented in the current clinical literature. (scalelive.com)
  • PCORI further stipulated that observational designs should meet certain benchmark criteria before valid generalizations can be made: Valid research questions , explicitly defined inclusion and exclusion criteria for participation, comparable interventions or treatments, sound secondary data sources, and transparency of treatment and analysis protocols. (scalelive.com)
  • The overall objective of this protocol is to implement evidence-informed, innovative interventions to increase adoption of findings from comparative effectiveness research (CER) for diabetes management and prevention in South Florida older veterans. (clinicaltrials.gov)
  • The goal of this paper is to synthesize the experiences of these studies to gain an understanding of how meaningful patient and stakeholder engagement can occur in clinical research of kidney diseases, and what the key barriers are to its implementation. (asnjournals.org)
  • The Distributed Ambulatory Research in Therapeutics Network (DARTNet) is a federated network of electronic health data from 8 organizations representing more than 500 clinicians and more than 400 000 patients. (nih.gov)
  • By linking electronic health records, laboratory and imaging data, and administrative data from diverse and geographically disparate patients, DARTNet provides important new insight into the comparative effectiveness of oral diabetes medications, and it is ready for expansion to further enable effectiveness research. (nih.gov)
  • In Australia, France, Germany, and the U.K., comparative effectiveness research is driven by demand for information by those making health care policy and practice decisions, including public and private payers, patients, clinical professionals, and policymakers. (commonwealthfund.org)
  • Purpose - Little is known about the comparative effects of common oral antidiabetic drugs ([OADs] metformin, sulfonylureas, or thiazolidinediones [THZs]) on chronic kidney disease (CKD) outcomes in patients newly diagnosed with type 2 diabetes (T2DM) and followed in community primary care practices. (rti.org)
  • Using false and misleading scare tactics, Conservatives for Patients Rights, a group opposed to comprehensive health care reform, announced last week a $1 million ad attacking comparative effectiveness. (focr.org)
  • Patient-centered research is primarily concerned with addressing the questions of most importance to patients and enhancing decision making through the generation of evidence that is reliable and actionable for a patient's unique circumstances. (asnjournals.org)
  • While Australia, France, Germany, and the U.K. have developed comparative effectiveness research agencies to suit their unique circumstances, the four agencies share common features that should be carefully considered by U.S. policymakers. (commonwealthfund.org)
  • This CER Systematic Reviews search strategy was developed to identify secondary research such as systematic reviews, meta-analyses, mathematical models, simulations and related studies in PubMed. (nih.gov)
  • The HSRProj search strategy includes Program Evaluation studies in addition to health services research studies focusing on CER. (nih.gov)
  • The international agencies rely mainly on syntheses of existing studies, rather than prospective research, owing to time and resource constraints. (commonwealthfund.org)
  • It is our hope that the experiences of these studies will further interest and capacity for incorporating patient and stakeholder perspectives in research of kidney diseases. (asnjournals.org)
  • While at Brookings, Daniel lead the Center for Health Policy's pharmaceutical and medical device policy portfolio that included developing strategies for better post-market safety surveillance and comparative effectiveness research, improving regulatory science, fostering practical steps for implementing expedited drug development and review tools, improving biomedical innovation, and supporting payment reform. (brookings.edu)
  • In just a few days a new Obamacare tax-that will double the following year-will kick in to fund "comparative effectiveness research" that's supposed to help the government save money by finding ways to ration healthcare. (judicialwatch.org)
  • Other countries' experiences in creating and operating comparative effectiveness research agencies may provide useful lessons to inform these discussions. (commonwealthfund.org)
  • For physician-researchers who have not yet decided what specific kind of research appeals to them or what will be the main focus of their career, "this session can help refine their thinking, and allow them to connect with established mentors in that field" she added. (vascularspecialistonline.com)
  • Our analyses will focus on severe hypoglycemia, though we will also explore the comparative effectiveness of these two agents by assessing switches between agents as a marker of drug ineffectiveness and/or intolerance (i.e., adverse event). (popdata.bc.ca)
  • The Harvard Pilgrim team includes experts in data standards, data security and privacy, medical ethics, patient-reported outcomes, project management, and research communications and dissemination. (healthcareitnews.com)
  • Dissemination and Adoption of Comparative Effectiveness Research Findings When Findings Challenge Current Practices. (hhs.gov)
  • Recognizing this fact, a sizable portion of the ARRA funding was devoted to research on the dissemination and implementation of CER. (hhs.gov)
  • The Institute for Clinical and Economic Review (ICER) on Tuesday announced plans to develop a review assessing the comparative clinical effectiveness and value of biologic therapies for moderate-to-severe asthma. (healtheconomics.com)
  • This lack of well-conducted research to test over-the-counter and prescription therapies is putting patients at risk of ineffective treatment and makes treatment decisions for patients and doctors very difficult. (healthcanal.com)
  • Professor Williams and his team are calling for new research into the comparative effectiveness of common topical and systemic therapies and to improve the understanding of the natural history, specific types, and triggers of acne, and how treatment affects the course of this poorly understood disease. (healthcanal.com)
  • By helping clinicians, patients, payers, and others to better distinguish between effective and ineffective (or potentially harmful) therapies, comparative effectiveness research (CER) has the potential to slow the growth of spending on healthcare without adversely affecting the quality of care. (hhs.gov)
  • The rich intellectual environment at Stanford, paired with our accessibility to the most advanced technology, is unmatched and ensures the rapid translation of pioneering laboratory research into life-saving clinical therapies for our patients. (stanford.edu)
  • From anti-cancer therapies and stem cell transplantation therapies for spinal cord injury to the elucidation of retinal neural circuitry and gene-environment interactions in fetal development, our research scientists are making quick progress tackling some of the most complex neurological disease questions in the neurodegenerative and neuroregenerative fields today. (stanford.edu)
  • Promising therapies are suggested by and explored with laboratory research, and some of these therapies, such as mild hypothermia, are then tested in the clinic. (stanford.edu)
  • We report numerical experiments that yield a heuristic approximation that applies even to very large horizons, and we propose a near-optimal strategy that remains valid even when the horizon is unknown or unbounded, thus applicable to comparative effectiveness studies on large populations or to standard-of-care recommendations. (pnas.org)
  • The first half of the chapter is a "portfolio analysis," which shows the representation of research areas, study populations, comparators, and study methodologies within the final 100 topics. (nap.edu)
  • Background: The $1.1 billion investment in comparative effectiveness research will reshape the evidence-base supporting decisions about treatment effectiveness, safety, and cost. (harvard.edu)
  • It will commission research to provide information about the best available evidence to help patients and their health care providers make more informed decisions. (nursingworld.org)
  • New models of shared decision making promise to bring greater emphasis to informed patient choice for "preference-sensitive" care, improving quality, safety, and effectiveness of health care by providing both patients and their health care providers with the evidence to assist in informed decision making. (wikipedia.org)
  • By linking electronic health records, laboratory and imaging data, and administrative data from diverse and geographically disparate patients, DARTNet provides important new insight into the comparative effectiveness of oral diabetes medications, and it is ready for expansion to further enable effectiveness research. (nih.gov)
  • The institute's first funding announcement solicited projects focused on methods for engaging patients and other stakeholders in all aspects of the research process," Dr. Beal and colleagues write. (medindia.net)
  • Applicants will be instructed to explain how their proposed research aligns with the statutory criteria and to describe how patients and other stakeholders will be engaged in and benefit from the research. (medindia.net)
  • Although they seek to demonstrate an intervention's effectiveness at a high level of statistical significance, randomized trials will always assign some patients to an inferior treatment and they will often assign patients to a treatment for which there is already partial evidence of its inferiority. (pnas.org)
  • This research can help patients, doctors, and others make decisions to improve health care. (gao.gov)
  • The money has primarily funded research and helped facilitate getting findings to the patients, doctors, and others who can use them. (gao.gov)
  • In Australia, France, Germany, and the U.K., comparative effectiveness research is driven by demand for information by those making health care policy and practice decisions, including public and private payers, patients, clinical professionals, and policymakers. (commonwealthfund.org)
  • HDBuzz is a patient organization that exists solely to provide news stories about clinical and basic research in the HD field for HD patients and those at risk for HD. (cfah.org)
  • But do we know which subset of patients each one of those is best suited to, and what is the differential effectiveness? (managedcaremag.com)
  • The Institute for Clinical and Economic Review (ICER) on Monday announced its plans to analyze the comparative clinical effectiveness and value of Novartis' canakinumab to reduce cardiovascular risk in patients diagnosed with atherosclerosis. (healtheconomics.com)
  • While this will certainly delay enrollment of patients into this trial, it also serves as a harbinger for the penurious nature of future government funding for comparative effectiveness research. (blogspot.com)
  • Health-care policy experts have made a strong case that comparative effectiveness research is an important instrument for comparing the value of competing strategies so that patients, providers, and policy makers can be offered appropriate recommendations for optimal care. (ascopost.com)
  • The simple definition of comparative effectiveness research is: a methodology that attempts to frame the delivery of health care by comparing the benefit and harm of available diagnostic, prognostic, and therapeutic strategies in representative patients to define the most effective, safe, and cost-effective approach. (ascopost.com)
  • Research plan and methodology The investigators hypothesize that rectal administration of indomethacin is not inferior to placement of a pancreatic duct stent in the prevention of pancreatitis after ERCP in high risk patients. (centerwatch.com)
  • Purpose - Little is known about the comparative effects of common oral antidiabetic drugs ([OADs] metformin, sulfonylureas, or thiazolidinediones [THZs]) on chronic kidney disease (CKD) outcomes in patients newly diagnosed with type 2 diabetes (T2DM) and followed in community primary care practices. (rti.org)
  • Objectives: Health insurers, physicians, and patients worldwide need information on the comparative effectiveness and safety of prescription drugs in routine care. (ispor.org)
  • Clinical research is based on the clustering of detectable patient outcomes around the mean, while smaller numbers of patients in both groups may get a lot better or worse. (blogspot.com)
  • All of these arguments are reduced to mere chatter, though, if comparative effectiveness research doesn't result in physicians altering how they treat their individual patients. (freethesaurus.com)
  • Some registries also allow researchers to contact and inform enrolled patients of new research opportunities. (facingourrisk.org)
  • Methicillin-Resistant Staphylococcus aureus (MRSA) has become a leading cause of pneumonia in the United States and there is limited data on treatment outcomes in obese patients.We evaluated the effectiveness of linezolid compared to vancomycin for the treatment of MRSA pneumonia in a national cohort of obese Veterans. (omicsonline.org)
  • In our real-world comparative effectiveness study among obese patients with suspected MRSA pneumonia, linezolid was associated with a significantly lower mortality rate as compared to the vancomycin-treated patients with lower vancomycin MICs. (omicsonline.org)
  • The study examined the effectiveness of a pharmacy-based comprehensive therapy management program-the Walgreens Connected Care® CF (Cystic Fibrosis) program-compared to a matched sample of control patients. (avalere.com)
  • This Special Article describes the creation and details of a network of EHR networks devised to use clinical data in EHRs for conducting CER, led by the American Academy of Pediatrics Pediatric Research in Office Settings (PROS). (aappublications.org)
  • Approximately $106 million in commitments to date are for PCORnet, a data research network aimed at improving the capacity for and speed of conducting CER. (gao.gov)
  • Comparative Effectiveness of Treatment for Major Depression-Utilize commercially available national claims data to evaluate the responsiveness and remission rates for major depression treatment and inform and expand knowledge on depression care. (aafp.org)
  • and coordinate with relevant federal health programs to build data capacity for this research. (gao.gov)
  • In other words, are we mature enough to use comparative effectiveness data to make tough decisions about what we will and won't pay for? (thehealthcareblog.com)
  • it is a way to make the best use of comparative data, and randomized trials will always be a component in that process. (ascopost.com)
  • The research network coordinating this project includes hospitals, urgent care centers, and outpatient clinics within Carolinas Healthcare System that share a common electronic medical record and billing system allowing for rapid collection of clinical and demographic data. (biomedcentral.com)
  • In this paper we describe lessons learned from the creation of Basic Stand Alone (BSA) Public Use Files (PUFs) for the Comparative Effectiveness Research Public Use Files Data Pilot Project (CER-PUF). (uni-muenchen.de)
  • A three-year $10.5 million federal grant awarded in December to help speed up mental health research will rely heavily on data from members of six Kaiser Permanente regions, including Kaiser Permanente Northern California. (kaiserpermanente.org)
  • Data on the comparative effectiveness of Diabetes Prevention Pro- sions (95% CI, 2.54 to 5.99). (cdc.gov)
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  • The goal of comparative effectiveness research is to improve health care while dealing with the seemingly ever-rising cost. (ajnr.org)
  • Critics of research that ultimately compares an outcome based on a better average value in an intervention group compared to an average value in the comparison group have a point. (blogspot.com)
  • This work aims to: (1) develop and refine topics for CERs that are informative to stakeholder decisional needs, (2) conduct CERs with systematic and transparent methods, and to (3) identify and explicate future research needs that are important to answering real-world healthcare decisions. (warwick.ac.uk)
  • Drawing upon decades of experience, RAND provides research services, systematic analysis, and innovative thinking to a global clientele that includes government agencies, foundations, and private-sector firms. (rand.org)
  • However, while acceptance of comparative effectiveness research is growing, operational as well as political and cultural challenges remain. (ascopost.com)
  • Multiple Imputation for Disclosure Limitation: Future Research Challenges. (uni-muenchen.de)
  • Special series on comparative effectiveness research: challenges to real-world solutions to quality improvement in personalized medicine. (blogspot.com)
  • The RAND Corporation is a research organization that develops solutions to public policy challenges to help make communities throughout the world safer and more secure, healthier and more prosperous. (rand.org)
  • And, although our research themes vary from lab to lab, they are all focused on aspects of disease and injury that can be investigated at the bench - and they all have clear implications for practices in the clinic and operating room. (stanford.edu)
  • The Costs and Cost Analysis search strategy is based on the Health Services Research query on Costs (Broad scope). (nih.gov)
  • The Comparative Effectiveness Research as Topic search strategy has been designed to retrieve citations "about" CER. (nih.gov)
  • In 2013, the first comprehensive search for COS in health research was conducted to ensure that the database content was comprehensive and up-to-date [ 4 ]. (plos.org)
  • domized controlled trial to compare the effectiveness of the The workplace may be an effective setting to offer DPPs. (cdc.gov)