Common variable immunodeficiency. Medical search

Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections.

An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.

A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN A.

A dysgammaglobulinemia characterized by a deficiency of IMMUNOGLOBULIN G.

Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

Immunoglobulin preparations used in intravenous infusion, containing primarily IMMUNOGLOBULIN G. They are used to treat a variety of diseases associated with decreased or abnormal immunoglobulin levels including pediatric AIDS; primary HYPERGAMMAGLOBULINEMIA; SCID; CYTOMEGALOVIRUS infections in transplant recipients, LYMPHOCYTIC LEUKEMIA, CHRONIC; Kawasaki syndrome, infection in neonates, and IDIOPATHIC THROMBOCYTOPENIC PURPURA.

An immunologic deficiency state characterized by selective deficiencies of one or more, but not all, classes of immunoglobulins.

A tumor necrosis factor receptor superfamily member found expressed on peripheral B-LYMPHOCYTES. It has specificity for B-CELL MATURATION ANTIGEN and TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 13.

Persistent abnormal dilatation of the bronchi.

Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.

Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses.

A classification of B-lymphocytes based on structurally or functionally different populations of cells.

Enlargement of the spleen.

Conditions resulting from abnormalities in the arteries branching from the ASCENDING AORTA, the curved portion of the aorta. These syndromes are results of occlusion or abnormal blood flow to the head-neck or arm region leading to neurological defects and weakness in an arm. These syndromes are associated with vascular malformations; ATHEROSCLEROSIS; TRAUMA; and blood clots.

A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.

A group of disorders having a benign course but exhibiting clinical and histological features suggestive of malignant lymphoma. Pseudolymphoma is characterized by a benign infiltration of lymphoid cells or histiocytes which microscopically resembles a malignant lymphoma. (From Dorland, 28th ed & Stedman, 26th ed)

Reproducible depletion of CD4+ lymphocytes below 300 per cubic millimeter in the absence of HIV infection or other known causes of immunodeficiency. This is a rare, heterogeneous syndrome and does not appear to be caused by a transmissible agent.

Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.

The smaller fragment formed when complement C4 is cleaved by COMPLEMENT C1S. It is an anaphylatoxin that causes symptoms of immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE) but its activity is weaker than that of COMPLEMENT C3A or COMPLEMENT C5A.

Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.

A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.

The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.

A member of tumor necrosis factor superfamily found on MACROPHAGES; DENDRITIC CELLS and T-LYMPHOCYTES. It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to TRANSMEMBRANE ACTIVATOR AND CAML INTERACTOR PROTEIN; and B CELL MATURATION ANTIGEN.

Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.

Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.

Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.

An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.

The type species of LENTIVIRUS and the etiologic agent of AIDS. It is characterized by its cytopathic effect and affinity for the T4-lymphocyte.

A member of the tumor necrosis factor receptor superfamily found on most T-LYMPHOCYTES. Activation of the receptor by CD70 ANTIGEN results in the increased proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.

The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus.

Congenital, inherited, or acquired anomalies of the CARDIOVASCULAR SYSTEM, including the HEART and BLOOD VESSELS.

A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.

The number of LYMPHOCYTES per unit volume of BLOOD.

Acquired hemolytic anemia due to the presence of AUTOANTIBODIES which agglutinate or lyse the patient's own RED BLOOD CELLS.

A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.

An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.

Species of the genus LENTIVIRUS, subgenus primate immunodeficiency viruses (IMMUNODEFICIENCY VIRUSES, PRIMATE), that induces acquired immunodeficiency syndrome in monkeys and apes (SAIDS). The genetic organization of SIV is virtually identical to HIV.

Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.

Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.

Surgical procedure involving either partial or entire removal of the spleen.

A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.

Invasion of the host organism by microorganisms that can cause pathological conditions or diseases.

The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.

Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.

A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.

Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.

Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.

Disorders characterized by proliferation of lymphoid tissue, general or unspecified.

A classification of lymphocytes based on structurally or functionally different populations of cells.

Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS).

In vivo modulation of cytokine synthesis by intravenous immunoglobulin. (1/340)

We examined the effects of intravenous immunoglobulin (IVIG) on cytokine regulation in vivo using samples taken before and after replacement-dose (200-400 mg/kg) IVIG in a group of patients with common variable immunodeficiency (CVID) and X-linked agammaglobulinaemia (XLA). The intracellular cytokine content of CD4+ and CD8+ lymphocytes, and their CD28+/- subsets, were measured following in vitro activation with phorbol myristate acetate (PMA) and ionomycin. The cytokines IL-2, interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha), and the early activation marker CD69, were assessed by four-colour flow cytometry of whole blood cultures taken before and after IVIG infusion. There was a significant increase in IL-2 expression in CD4+ (and CD4+28-) cells and an increase in TNF-alpha expression in CD8+28- cells following IVIG in CVID, but not in XLA patients. IFN-gamma and CD69 expression were not affected by IVIG infusion. This increase in TNF-alpha and IL-2, combined with unchanged IFN-gamma expression, is evidence against the putative 'anti-inflammatory' role of IVIG, and may explain the failure of resolution of granulomata in CVID patients treated with IVIG alone. (+info)

HLA class II homozygosity confers susceptibility to common variable immunodeficiency (CVID). (2/340)

Most cases of CVID occur sporadically, but familial cases do also occur and 15% of the patients with the disease have first degree relatives with IgA deficiency (IgAD). Our purpose was to study CVID association with HLA class II alleles and to ascertain whether this disease shares a common genetic background with IgAD in our population. Patients with CVID (n = 42), were typed using gene amplification and sequence-specific oligonucleotide probing for HLA-DRB1, DRB3, DQA1 and DQB1 loci and their typing compared with that of 96 IgAD and 334 healthy controls. We observed a positive association between non-Asp residues at position 57 of the HLA-DQbeta chain and CVID, although much weaker than in IgAD. Further, we found an association between CVID and homozygosity for genes encoding HLA class II molecules, especially HLA-DQ, not seen in IgAD. The data support the hypothesis that a restricted diversity of HLA class II molecules may contribute to susceptibility to CVID. (+info)

Gastric pathology in patients with common variable immunodeficiency. (3/340)

BACKGROUND/AIMS: Common variable immunodeficiency (CVID) is an immunological disorder characterised by defective antibody production. Patients with CVID have a high risk of gastric cancer. It has been suggested that gastric cancer results from an interaction between environmental factors and a genetic predisposition. The role of Helicobacter pylori as an environmental factor in gastric carcinogenesis is of current interest. Moreover, p53 gene mutations have been reported in gastric cancer. This study focuses on the gastric pathology of patients with CVID and correlation with H pylori infection. METHODS: Thirty four consecutive dyspeptic patients with CVID (mean age 49.6 years, range 14-72; 17 men) were included in the study. An upper gastrointestinal endoscopy was performed and biopsy specimens were taken from the antrum, incisura angularis, and gastric body. Biopsies were used for histological assessment, to identify the presence of H pylori, and to evaluate p53 overexpression. RESULTS: H pylori infection was detected in 14/34 (41%) patients. Chronic active gastritis involving both antrum and body was observed more frequently in H pylori positive (79%) than H pylori negative (20%) patients (p = 0.001). Similarly, a histological feature of multifocal atrophic gastritis was found more frequently in infected (50%) than uninfected patients (10%) (p = 0.012). In addition, one case of gastric adenocarcinoma and another of notable dysplasia were observed in the H pylori positive group. Overexpression of p53 was found in six (18%) patients, including one with normal gastric mucosa. CONCLUSIONS: It can be hypothesised that both H pylori and p53 alterations play a role in the gastric carcinogenesis of patients with CVID. (+info)

Effect of IVIG on the hair regrowth in a common variable immune deficiency patient with alopecia universalis. (4/340)

Common variable immune deficiency (CVID) is associated with a variety of autoimmune diseases. Alopecia universalis (AU), believed to have an autoimmune basis, has been found in 1.6% of patients with CVID. Intravenous immunoglobulin (IVIG) therapy is used in various immunodeficiency disorders including CVID, and benefit has been shown in the therapy of autoimmune diseases. We report a patient with CVID and AU treated with IVIG who experienced significant hair regrowth. An 8-year-old girl with CVID and AU was treated with IVIG 400 mg/kg every 4 weeks. Since her second dose of IVIG, regrowth of eyelashes, eyebrows, body and scalp hair was observed in this patient. At present, about 1 year treat-meant of IVIG, significant hair regrowth is noted with 5-6 cm of scalp hair. We believe that IVIG may be beneficial in the treatment of AU, at least in patients with CVID. (+info)

Identification of a subset of common variable immunodeficiency patients with impaired B-cell protein tyrosine phosphorylation. (5/340)

The mechanisms responsible for common variable immunodeficiency syndrome (CVID) are as yet unknown. In the present study, we show that the B-cell dysfunction in a subset of CVID patients is caused by defective protein tyrosine phosphorylation (PTP). We demonstrated that the PTP level and immunoglobulin (Ig) secretion malfunctions can be successfully repaired when normal plasma membrane components are implanted into these patients' B cells. Stimulation of CVID patients' peripheral blood mononucleated cells with anti-Ig antibody revealed that 7 of 11 patients had lower PTP levels than those found in the normal donor cells. Plasma membrane implantation to the cells of these patients resulted in elevated PTP levels which reached normal levels upon stimulation with anti-human Ig antibody. The results revealed two distinct groups of CVID patients. The first group included patients whose B cells expressed low PTP levels after Ig stimulation. In these patients the plasma membrane implantation restored the normal PTP level as well as the ability to secrete IgM and/or IgG after B-cell stimulation. In the second group, patients whose B cells expressed a normal PTP level after Ig stimulation, with no restoration of their ability to secrete Ig upon plasma membrane implantation and lipopolysaccharide stimulation. We conclude that the first group has an early signal transduction defect located in the B-cell plasma membrane, while in the second group the defect is located elsewhere. (+info)

Up-regulation of IL-12 in monocytes: a fundamental defect in common variable immunodeficiency. (6/340)

We show that LPS-stimulated circulating CD14-positive monocytes from patients with common variable immunodeficiency (CVID) express a higher proportion of intracellular IL-12-positive cells than monocytes from patients with X-linked agammaglobulinemia or normal subjects. We used four-color flow cytometry and measured IL-12 with an Ab to the p40 subunit following stimulation with LPS. The raised IL-12 is associated with an increased frequency of IFN-gamma-positive T cells, but not of IFN-gamma-positive CD56+ NK cells. These increases in frequency of cytokine-positive cells are due to a decrease in the absolute numbers of circulating monocytes and T cells that are negative for IL-12 and IFN-gamma, respectively. The increased frequency of IL-12-positive monocytes appears to be selective because TNF-alpha was not increased, and is thus unlikely to reflect a general activation. Chronic infection is also unlikely to explain our data since cells from X-linked agammaglobulinemia patients with a similar Ig deficiency do not show these changes. Our data suggest a fundamental abnormality in the IL-12/IFN-gamma circuit in CVID, with up-regulation of IL-12 being the "primary" factor. This imbalance is likely to skew the immune response away from Ab production and also explains the failure of CVID T cells to make Ag-specific memory cells and the chronic inflammatory and granulomatous complications that are a feature of CVID. This disease appears to be a rare example of a polarized Th1-type response and may in part be due to a genetic defect in the control of IL-12 production. (+info)

Lymphoid interstitial pneumonitis associated with common variable hypogammaglobulinaemia treated with cyclosporin A. (7/340)

Lymphoid interstitial pneumonitis (LIP) is a rare clinicopathological entity that may be associated with common variable immune deficiency (CVID) and may lead to respiratory failure and death. Some patients may respond to prolonged corticosteroid treatment. We hypothesised that, in view of the predominant T cell nature of LIP, cyclosporin A would be a more appropriate choice of immunosuppressive agent and report the first case of its successful use in a woman with LIP associated with CVID. (+info)

Long-term outcome of chronic hepatitis C virus infection in primary hypogammaglobulinaemia. (8/340)

The clinical course of HCV infection in patients with primary hypogammaglobulinaemia appears to be more severe than in immunocompetent patients. We studied the long-term course of chronic HCV infection in 20 Norwegian hypogammaglobulinaemia patients with a 13-15 year known history of HCV infection. Twelve of 20 patients developed cirrhosis during the observation period (1984-1999), and the remaining eight also had chronic liver disease verified by liver biopsy in the majority of the cases. Eleven of the 20 patients are dead. Two died following liver transplantation for HCV cirrhosis. Five died due to terminal liver failure without receiving a liver allograft. Two patients died from other causes, but with advanced liver disease contributing to the outcome, while two deaths were unrelated to the HCV infection. Among patients with common variable immunodeficiency (CVI), five out of six are dead. Two patients cleared the hepatitis C virus 3 years following interferon monotherapy, while three patients achieved a sustained response to combination therapy with interferon and ribavirin. Viral load did not seem to have a major impact on disease progression. Our results emphasize the severity of hepatitis C virus infection in patients with hypogammaglobulinaemia. Patients with CVI appear to have the poorest prognosis. (+info)

The two most common cancers in common variable immunodeficiency patients include lymphoma and certain stomach cancers. The risk ... People with common variable immunodeficiency have trouble fighting off infections due to the lack of antibodies produced which ... Common variable immunodeficiency (CVID) is an immune disorder characterized by recurrent infections and low antibody levels, ... for these given cancers is almost fifty times greater in common variable immunodeficiency patients than those without. ...

https://en.wikipedia.org/wiki/Common_variable_immunodeficiency

... common variable immunodeficiency; severe combined immunodeficiency; immunoglobulin-G-subclass deficiencies with recurrent ... although some small-scale studies have indicated that a particular cohort of patients with common variable immunodeficiency ( ... Immunoglobulin therapy is also used in some treatment protocols for secondary immunodeficiencies such as human immunodeficiency ... Common side effects include pain at the site of injection, muscle pain, and allergic reactions. Other severe side effects ...

https://en.wikipedia.org/wiki/Immunoglobulin_therapy

Furthermore, those with Common Variable Immunodeficiency (CVID) may be at even higher risk. One study of 80 CVID patients found ... "Sarcoidosis and common variable immunodeficiency. Report of 8 cases and review of the literature". Medicine. 75 (5): 251-261. ... The most common abnormality is involvement of the facial nerve, which may lead to reduced power on one or both sides of the ... Erythema nodosum is far more common in men than in women and in Caucasians than in other races. In Japanese patients, ...

https://en.wikipedia.org/wiki/Neurosarcoidosis

IgA deficiency and common variable immunodeficiency (CVID) feature similar B cell differentiation arrests, but it does not ... 2002). "Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a combined ... Hammarström, L.; Vorechovsky, I.; Webster, D. (2000). "Selective IgA deficiency (SIgAD) and common variable immunodeficiency ( ... and common variable immunodeficiency (CVID)". Clinical and Experimental Immunology. 120 (2): 225-231. doi:10.1046/j.1365- ...

https://en.wikipedia.org/wiki/Selective_immunoglobulin_A_deficiency

Granulomatous-lymphocytic lung disease shortens survival in common variable immunodeficiency. J Allergy Clin Immunol 2004;114: ... Granulomatous-lymphocytic interstitial lung disease (GLILD) is a lung complication of common variable immunodeficiency ... Multicenter experience in hematopoietic stem cell transplantation for serious complications of common variable immunodeficiency ... in patients with common variable immunodeficiency (CVID). J Clin Immunol 2013;33:30-39 PMID 22930256 PMC3557581 Wehr C, Gennery ...

https://en.wikipedia.org/wiki/Granulomatous–lymphocytic_interstitial_lung_disease

"Respiratory Infections and Antibiotic Usage in Common Variable Immunodeficiency" (PDF). The Journal of Allergy and Clinical ... Respiratory Infections and Antibiotic Usage in Common Variable Immunodeficiency Epidemiology, Pathogenesis and Treatment of ... He is currently the Principal Investigator of the STILLPAD-UK study, a prospective study of lung disease in Immunodeficiency. ... the largest Primary Immunodeficiency Centre in Europe, Seneviratne was a Consultant and Lead Clinician in Clinical Immunology ...

https://en.wikipedia.org/wiki/Suranjith_Seneviratne

"TACI is mutant in common variable immunodeficiency and IgA deficiency". Nature Genetics. 37 (8): 829-34. doi:10.1038/ng1601. ... TACI mutations are associated with immunodeficiency in humans, as a significant proportion of CVID patients have TACI mutations ...

https://en.wikipedia.org/wiki/Transmembrane_activator_and_CAML_interactor

"Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency". Nature Immunology. 4 (3): 261-8. doi: ...

https://en.wikipedia.org/wiki/CD278

"common variable immunodeficiency" at Dorland's Medical Dictionary Watson, Stephanie (18 September 2018). "Hypogammaglobulinemia ... such as common variable immunodeficiency, or it may be caused by secondary effects such as medication, blood cancer, or poor ... common variable immunodeficiency (CVID), hyper-IgM syndromes, IgG subclass deficiency, isolated non-IgG immunoglobulin ... CVID is the most common form of primary immunodeficiency. SCID is considered a medical emergency and suspected cases require ...

https://en.wikipedia.org/wiki/Hypogammaglobulinemia

Antibody deficiencies are also common, including common variable immunodeficiency and IgA deficiency. T-cell immunity is normal ... The most common characteristics include a distinct craniofacial phenotype (microcephaly, micrognathia, short philtrum, ... Less common characteristics include hypospadias, colobomata of the iris, renal anomalies, and deafness. ... Commons category link from Wikidata, Autosomal monosomies and deletions, Rare syndromes, Genodermatoses). ...

https://en.wikipedia.org/wiki/Wolf–Hirschhorn_syndrome

"Disseminated Mycoplasma orale infection in a patient with common variable immunodeficiency syndrome". Diagnostic Microbiology ... Contamination is common due to their small physical size, lack of cell wall, and pleomorphism. Pleomorphism is defined as an ... This comes as no surprise, as the class Mollicutes contains common commensals or pathogens of several different organisms. Many ...

https://en.wikipedia.org/wiki/Mycoplasma_orale

2004). "Common variable immunodeficiency is associated with defective functions of dendritic cells". Blood. 104 (8): 2441-3. ... In the case of dendritic cell deficiency, like in common variable immunodeficiency (CVID), patients suffer from ...

https://en.wikipedia.org/wiki/Danger_model

"Primary cutaneous actinomycosis caused by Actinomyces bovis in a patient with common variable immunodeficiency". The Journal of ... Common causes of trauma to the oral mucosa include consumption of abrasive feed or foreign bodies (thorns, wire, etc.), or ... The other explains its common name, lumpy jaw, as A. bovis bacteria infect the mandibular bone, causing osteomyelitis and the ...

https://en.wikipedia.org/wiki/Actinomyces_bovis

"Optimal use of ivig in a patient with Behçet syndrome and common variable immunodeficiency". Ann. Allergy Asthma Immunol. 109 ( ... The most common symptoms include painful sores on the mucous membranes of the mouth and other parts of the body, inflammation ... While rare in the United States and Europe, it is more common in the Middle East and Asia. In Turkey, for example, about 2 per ... Most common arterial lesions are occlusions or stenosis and aneurysms or pseudoaneurysms.[citation needed] The cause is not ...

https://en.wikipedia.org/wiki/Behçet's_disease

It has been suggested that Good Syndrome is a subset of common variable immunodeficiency (CVID). The mainstay of treatment ... The immunodeficiency may occur before or after the diagnosis of a thymoma. Immunodeficiency involves both deficient humoral and ... Thymoma with immunodeficiency (also known as "Good syndrome") is a rare disorder that occurs in adults in whom ... Immunodeficiency does not resolve after thymectomy. Immunosuppression is sometimes used. The Centers for Disease Control and ...

https://en.wikipedia.org/wiki/Thymoma_with_immunodeficiency

1999) and Baldwin (1996).[supplied by OMIM] Mutation of the NFKB2 gene has been linked to Common variable immunodeficiency ( ... "Germline mutations in NFKB2 implicate the noncanonical NF-κB pathway in the pathogenesis of common variable immunodeficiency". ... "NFKB2 mutation in common variable immunodeficiency and isolated adrenocorticotropic hormone deficiency: A case report and ... The mutation occurs at the C-terminus of NFKB2 and it causes common variable immunodeficienciency which in turn causes ...

https://en.wikipedia.org/wiki/NFKB2

"Individuals with IgA deficiency and common variable immunodeficiency share polymorphisms of major histocompatibility complex ... whereas HLA types more common in Italy, Greece and the middle east are more common within this region of France. Other ... People with many common ancestors from Ireland share similar risks of disease. In the case of juvenile diabetes a clear ... A common serologically defined haplotype in Europeans is HLA A1-B8-DR3-DQ2.5 (see above). In non-persistent sarcoidosis this ...

https://en.wikipedia.org/wiki/HLA_DR3-DQ2

"Symptomatic hypoglycemia in a child with common variable immunodeficiency: Deficient anterior pituitary with variable immune ... genetic disorder that is characterized by adrenocorticotropic hormone deficiency combined with common variable immunodeficiency ... DAVID syndrome, short for deficient anterior pituitary with variable immune deficiency syndrome, is a rare ... having variable endocrine and immune deficiencies". BMC Medical Genetics. 15: 139. doi:10.1186/s12881-014-0139-9. PMC 4411703. ...

https://en.wikipedia.org/wiki/DAVID_syndrome

X-linked agammaglobulinemia Common variable immunodeficiency (CVID) "X-linked Immunodeficiency With Hyper IgM Clinical ... The fungus is common and is present in over 70% of healthy people's lungs, however, Hyper IgM patients are not able to fight it ... "OMIM Entry - # 308230 - IMMUNODEFICIENCY WITH HYPER-IgM, TYPE 1; HIGM1". www.omim.org. Retrieved 16 November 2016. "OMIM Entry ... "OMIM Entry - # 606843 - IMMUNODEFICIENCY WITH HYPER-IgM, TYPE 3; HIGM3". www.omim.org. Retrieved 16 November 2016. "OMIM Entry ...

https://en.wikipedia.org/wiki/Hyper_IgM_syndrome

Common variable immunodeficiency is thought to be due to a problem in the differentiation from lymphocytes to plasma cells. The ... Terminally differentiated plasma cells express relatively few surface antigens, and do not express common pan-B cell markers, ...

https://en.wikipedia.org/wiki/Plasma_cell

Children with common variable immunodeficiency (CVID) are also at a higher risk of developing a lymphoproliferative disorder.[ ... Viral infection is a very common cause of lymphoproliferative disorders. In children, the most common is believed to be ... The Epstein-Barr virus, which infects >90% of the world population, is also a common cause of these disorders, being ... Boys with X-linked immunodeficiency syndrome are at a higher risk of mortality associated with Epstein-Barr virus infections, ...

https://en.wikipedia.org/wiki/Lymphoproliferative_disorders

Certain other immune deficiency states (e.g. common variable immunodeficiency and IgA deficiency) are also associated with ... December 2002). "Cancer risk among patients with IgA deficiency or common variable immunodeficiency and their relatives: a ... Because chronic viral hepatitis is so common, and liver cancer so deadly, liver cancer is one of the most common causes of ... Worldwide in 2015, the most common causes of cancer death were lung cancer (1.6 million deaths), liver cancer (745,000 deaths ...

https://en.wikipedia.org/wiki/Infectious_causes_of_cancer

"Retinal vasculitis occurring with common variable immunodeficiency syndrome," American Journal of Ophthalmology, vol. 129, no. ... Behçet's disease Common Variable Immune Deficiency Eales disease Granulomatosis with polyangiitis Idiopathic Retinal Vasculitis ...

https://en.wikipedia.org/wiki/Retinal_vasculitis

2002). "Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency". Clin ...

https://en.wikipedia.org/wiki/SWAP70

... an oral IL-12/IL-23 inhibitor for the treatment of autoimmune diseases and common variable immunodeficiency". IDrugs. 10 (1): ...

https://en.wikipedia.org/wiki/Apilimod

Common variable immunodeficiency IPEX syndrome Along with treatment for infections and other complications several additional ... The presentation of this condition is variable making the diagnosis difficult. The most common features include Immune ...

https://en.wikipedia.org/wiki/LPS-responsive_beige-like_anchor_protein_deficiency

This includes, but is not limited to, common variable immunodeficiency, X-linked agammaglobulinemia, congenital ... Common applications are ophthalmic surgery, in combination with local anesthetics. It also increases the absorption rate of ... The resulting HA fragments of variable size are then further hydrolized by HYAL1 after being internalized into endo-lysosomes; ... ISBN 978-0-8153-4105-5. Media related to Hyaluronidase at Wikimedia Commons "Hyaluronidase". Drug Information Portal. U.S. ...

https://en.wikipedia.org/wiki/Hyaluronidase

... that was associated with single common variable immunodeficiency (CVID). Numerous SNPs were identified throughout the ZNF226 ... These repetitions appear most common within the zf-C2H2 and zinc finger double domains of the protein, notably with cysteine ... Predicted secondary structures of ZNF226 demonstrate a variable number of alpha helices, beta-stranded bridges, and random ... "Deep sequencing of large library selections allows computational discovery of diverse sets of zinc fingers that bind common ...

https://en.wikipedia.org/wiki/Zinc_finger_protein_226

B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in ... and IgG4 deficiency is very common but usually asymptomatic. IgG1 is present in the bloodstream at a percentage of about 60-70 ...

https://en.wikipedia.org/wiki/IgG_deficiency

One example is common variable immunodeficiency (CVID) where multiple autoimmune diseases are seen, e.g., inflammatory bowel ... Immunodeficiency is also the hallmark of acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency virus ... be related to illnesses such as X-Linked Agammaglobulinemia and Common Variable Immune Deficiency Secondary immunodeficiencies ... Primary Immunodeficiency is also known as congenital immunodeficiencies. Many of these disorders are hereditary and are ...

https://en.wikipedia.org/wiki/Immunodeficiency

The most common bacteriophages used in phage display are M13 and fd filamentous phage, though T4, T7, and λ phage have also ... "In vitro evolution of a neutralizing human antibody to human immunodeficiency virus type 1 to enhance affinity and broaden ... filamentous phage displaying antibody variable domains". Nature. 348 (6301): 552-4. Bibcode:1990Natur.348..552M. doi:10.1038/ ... "A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of ...

https://en.wikipedia.org/wiki/Phage_display

... such as those with common variable immunodeficiency or with a suppressed immune system after organ transplantation. These ... Groups 1, 2, 3, and 4 last shared a common ancestor in AD 867. The group 2 and group 4 viruses last shared a common ancestor in ... It is common both in the developed and developing world. Those under the age of five are most often affected, and in this group ... Some people have common variations of the MDA-5 gene that could make them more susceptible to norovirus infection. Viruses in ...

https://en.wikipedia.org/wiki/Norovirus

... familial Common cold Common mesentery Common variable immunodeficiency Compartment syndrome Complement component 2 deficiency ... protozoal infections Central serous chorioretinopathy Central type neurofibromatosis Centromeric instability immunodeficiency ...

https://en.wikipedia.org/wiki/List_of_diseases_(C)

Oropharyngeal candidiasis is common during cancer care, and it is a very common oral sign in individuals with HIV. Oral ... The global human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) pandemic has been an important factor in ... Hyperplastic candidiasis is variable. Usually there is hyperplastic and acanthotic epithelium with parakeratosis. There is an ... In humans, oral candidiasis is the most common form of candidiasis, by far the most common fungal infection of the mouth, and ...

https://en.wikipedia.org/wiki/Oral_candidiasis

1 adverse variable except age Intermediate: 2 adverse characteristics or age > 65 years High: > 2 adverse characteristics Five- ... human immunodeficiency virus, and rickettsiosis. There are genetic factors, with first-degree relatives of Waldenström ... "High-Resolution Genomic Analysis in Waldenström's Macroglobulinemia Identifies Disease-Specific and Common Abnormalities with ...

https://en.wikipedia.org/wiki/Waldenström_macroglobulinemia

Some of the more frequently seen forms of PID include common variable immunodeficiency, severe combined immunodeficiency, X- ... Milder forms of primary immunodeficiency, such as selective immunoglobulin A deficiency, are fairly common, with random groups ... Representing PAGID (Pan-American Group for Immunodeficiency) and ESID (European Society for Immunodeficiencies)". Clin. Immunol ... "Primary immunodeficiency diseases: An update from the International Union of Immunological Societies Primary Immunodeficiency ...

https://en.wikipedia.org/wiki/Primary_immunodeficiency

Other common prefixes include "v" for viral (miRNA encoded by a viral genome) and "d" for Drosophila miRNA (a fruit fly ... While researchers focused on miRNA expression in physiological and pathological processes, various technical variables related ... human immunodeficiency virus (HIV) transactivating response RNA (TAR) binding protein], PACT (protein activator of the ... For example, 90 families of miRNAs have been conserved since at least the common ancestor of mammals and fish, and most of ...

https://en.wikipedia.org/wiki/MicroRNA

Dunn DM, Ishigami T, Pankow J, von Niederhausern A, Alder J, Hunt SC, Leppert MF, Lalouel JM, Weiss RB (2002). "Common variant ... The antibodies specific to NEDD4-2 recognize two species of ~110-115 kDa in most tissues, with one being variable depending on ... "NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and ... Itani OA, Campbell JR, Herrero J, Snyder PM, Thomas CP (Nov 2003). "Alternate promoters and variable splicing lead to hNedd4-2 ...

https://en.wikipedia.org/wiki/NEDD4L

The most common physical finding is short stature. The four patients described by Frydman et al. (1986) had a stature that was ... Premature death may result from the immunodeficiency and/or autoimmunity associated with this condition. This condition is ... although it's phenotypical nature is highly variable among patients with the condition, including symptoms such as muscle ... These are common skeletal features shared by patients with spondyloenchondroplasia. Two brothers born of a consanguineous first ...

https://en.wikipedia.org/wiki/Spondyloenchondrodysplasia

Common variable immunodeficiency (acquired hypogammaglobulinemia) Complement deficiency DiGeorge syndrome (DiGeorge anomaly, ... the terms human immunodeficiency virus and acquired immunodeficiency syndrome are abbreviated to HIV and AIDS, respectively. ... Immunodeficiency with hyper-IgM Immunodeficiency-centromeric instability-facial anomalies syndrome (ICF syndrome) Isolated IgA ... severe mixed immunodeficiency syndrome, thymic alymphoplasia) Shwachman-Bodian-Diamond syndrome Thymoma with immunodeficiency ( ...

https://en.wikipedia.org/wiki/List_of_skin_conditions

Inherited immune deficiency - severe combined immunodeficiency, common variable immune deficiency, ataxia-telangiectasia, ... Wiskott-Aldrich syndrome, immunodeficiency with short-limbed dwarfism, immunodeficiency with thymoma, purine nucleoside ... Neutrophils are the most common cell type seen in the early stages of acute inflammation. The average lifespan of inactivated ... For example, the most common cause of acquired neutropenia is drug-induced, so an individual may have symptoms of medication ...

https://en.wikipedia.org/wiki/White_blood_cell

There are >3,500 different mosquito species with the Aedes and Culex genera being common in North America. It is assumed that ... Natkunam Y, Gratzinger D, Chadburn A, Goodlad JR, Chan JK, Said J, Jaffe ES, de Jong D (November 2018). "Immunodeficiency- ... mosquito saliva proteins to desensitize individuals against developing reactions to mosquito bites has yielded variable results ...

https://en.wikipedia.org/wiki/Mosquito_bite_allergy

The cDNA is sequenced and the sequence encoding the variable heavy and variable light chains of these antibodies are cloned ... Additional common genetic changes in B-cell ALL involve non-inherited mutations to PAX5 and IKZF1. In T-cell ALL, LYL1, TAL1, ... These include: Down syndrome, Fanconi anemia, Bloom syndrome, X-linked agammaglobulinemia, severe combined immunodeficiency, ... In the United States it is the most common cause of cancer and death from cancer among children. ALL is notable for being the ...

https://en.wikipedia.org/wiki/Acute_lymphoblastic_leukemia

... s are common pets throughout the world, and their worldwide population as of 2007 exceeded 500 million. Cats have been used ... In addition, bites are probably the main route of transmission of feline immunodeficiency virus. Sexually active males are ... and a variable number of caudal vertebrae in the tail (humans have only three to five vestigial caudal vertebrae, fused into an ... Another common reason for fighting in domestic cats is the difficulty of establishing territories within a small home. Female ...

https://en.wikipedia.org/wiki/Cat

... common variable, 1; 607594; ICOS Immunodeficiency, common variable, 2; 240500; TNFRSF13B Immunodeficiency, common variable, 3; ... common variable, 4; 613494; TNFRSF13C Immunodeficiency, common variable, 5; 613495; MS4A1 Immunodeficiency, common variable, 6 ... CD79B Immunodeficiency, isolated; 300584; IKBKG Immunodeficiency, X-linked, with hyper-IgM; 308230; TNFSF5 Immunodeficiency- ... STIM1 Immunodeficiency due to defect in CD3-zeta; 610163; CD247 Immunodeficiency due to defect in MAPBP-interacting protein; ...

https://en.wikipedia.org/wiki/List_of_OMIM_disorder_codes

... genetic disorder that is characterized by adrenocorticotropic hormone deficiency combined with common variable immunodeficiency ... this common structure is responsible for excessively tanned skin in Addison's disease). After a short period of time, ACTH is ... a common cause of ACTH secreted ectopically Congenital adrenal hyperplasia, diseases in the production of cortisol Nelson's ...

https://en.wikipedia.org/wiki/Adrenocorticotropic_hormone

A common application of PCR is the study of patterns of gene expression. Tissues (or even individual cells) can be analyzed at ... The first category is called variable number tandem repeats (VNTR), which are 10-100 base pairs long and the second category is ... May 1987). "Identification of human immunodeficiency virus sequences by using in vitro enzymatic amplification and oligomer ... The individual steps common to most PCR methods are as follows: Initialization: This step is only required for DNA polymerases ...

https://en.wikipedia.org/wiki/Polymerase_chain_reaction

Immunodeficiency The Immunodeficiency section tabulates known pathogens of concern in glucocorticoid induced immunodeficiency. ... Anticoagulants Anticoagulants exhibit variable interactions; monitoring coagulation indices is recommended to achieve the ... Iatrogenic Cushing's Syndrome is a direct complication of glucocorticoid therapy, and the most common cause of exogenous ... In Lupus Nephritis, a common manifestation of SLE, patients are often prescribed methylprednisolone concomitantly with ...

https://en.wikipedia.org/wiki/Methylprednisolone

Immunodeficiency can be profound. Loss of the thymus at an early age through genetic mutation (as in DiGeorge syndrome, CHARGE ... The most common congenital cause of thymus-related immune deficiency results from the deletion of the 22nd chromosome, called ... and variable other associated problems, such as congenital heart disease, and abnormalities of mouth (such as cleft palate and ... Severe combined immunodeficiency (SCID) are group of rare congenital genetic diseases that can result in combined T, B, and NK ...

https://en.wikipedia.org/wiki/Thymus

The two most common chronic conditions in the elderly are high blood pressure and arthritis, with diabetes, coronary heart ... it is not known is there is a direct cause and effect relationship between these two variables. The epidemiology of ... genetic disorders and some viral diseases such as hepatitis C and acquired immunodeficiency syndrome. An illness which is ... While risk factors vary with age and gender, most of the common chronic diseases in the US are caused by dietary, lifestyle and ...

https://en.wikipedia.org/wiki/Chronic_condition

... but fails of doing it in human cells that originates from variable malignancies such as U937, Namalwa, and A549. Variable cell ... Shi LY, Li M, Yuan LJ, Wang Q, Li XM (2008). "A new paramyxovirus, Tianjin strain, isolated from common cotton-eared marmoset: ... human immunodeficiency virus, influenza virus A and Sendai virus". Advances in Enzyme Regulation. 36: 325-47. doi:10.1016/0065- ... Variable sialidases can cause this effect, including NA from Newcastle disease virus that have been shown to cleave 2,3-, 2,6 ...

https://en.wikipedia.org/wiki/Murine_respirovirus

HBV is the most common one among those hepatitis viruses. It can cause chronic infection of liver in humans, which has become a ... The transgenic mice were not susceptible to HBV, but mice with severe combined immunodeficiency (SCID) can develop chronic ... while the plus strand spans only about two-thirds of the genome length and have variable 3' ends. But for the avihepadnaviruses ... As the same with the orthohepadnaviruses, avihepadnaviruses have a rather narrow host range, but its common host are ducks and ...

https://en.wikipedia.org/wiki/Transmission_of_hepadnaviruses

The historically most common form of DLBCL-CI, often termed pyothorax-associated lymphoma (PAL), exemplifies this disease. PAL ... consists of variable histology with infiltrative lesions consisting of wither anaplastic cells and prominent Reed-Sternberg- ... particularly those with an immunodeficiency, develop any one of various EBV-associated benign or malignant diseases. The EBV- ...

https://en.wikipedia.org/wiki/Diffuse_large_B-cell_lymphoma_associated_with_chronic_inflammation

Less common modes of transmission include vertical transmission, which is transmission from mother to child during pregnancy or ... Global rates of chikungunya infection are variable, depending on outbreaks. When chikungunya was first identified in 1952, it ... and human immunodeficiency virus infection tend to have more severe cases of Chikungunya. Around 1 to 5 in 1,000 people with ... The best means of prevention is overall mosquito control and the avoidance of bites in areas where the disease is common. This ...

https://en.wikipedia.org/wiki/Chikungunya

The most common associated with neurosyphilitic meningitis is cranial nerve palsy, especially of the facial nerve. Nearly any ... Reported sensitivity is variable. False-negative antibody test result occurring when antibody concentration is so high that ... pallidum with human immunodeficiency virus (HIV) has been found to affect the course of syphilis. Syphilis can lie dormant for ... The most common form of ocular syphilis is uveitis. Other forms include episcleritis, vitritis, retinitis, papillitis, retinal ...

https://en.wikipedia.org/wiki/Neurosyphilis

1989). "A survival analysis of hospitalization among patients with acquired immunodeficiency syndrome". American Journal of ... Tobin, James (1958). "Estimation of relationships for limited dependent variables" (PDF). Econometrica. 26 (1): 24-36. doi: ... A common misconception with time interval data is to class as left censored intervals where the start time is unknown. In these ... The problem of censored data, in which the observed value of some variable is partially known, is related to the problem of ...

https://en.wikipedia.org/wiki/Censoring_(statistics)

Common variable immunodeficiency (CVID) is a disorder that involves the following: (1) low levels of most or all of the ... encoded search term (Common Variable Immunodeficiency) and Common Variable Immunodeficiency What to Read Next on Medscape ... Common Variable Immunodeficiency Clinical Presentation. Updated: Jun 08, 2022 * Author: Robert A Schwartz, MD, MPH; Chief ... Common variable immunodeficiency (CVID) in a family: an autosomal dominant mode of inheritance. Neth J Med. 2001 Sep. 59(3):134 ...

https://www.medscape.com/answers/1051103-109512/which-physical-findings-are-characteristic-of-common-variable-immunodeficiency-cvid

New insights into common variable immunodeficiency. Ann Intern Med. 1993;118:720-30.PubMedGoogle Scholar ... West Nile Virus Meningitis in Patient with Common Variable Immunodeficiency. Emerging Infectious Diseases. 2003;9(10):1353-1354 ... West Nile Virus Meningitis in Patient with Common Variable Immunodeficiency On This Page ... West Nile Virus Meningitis in Patient with Common Variable Immunodeficiency. Volume 9, Number 10-October 2003 ...

https://wwwnc.cdc.gov/eid/article/9/10/03-0195

common variable unclassifiable immunodeficiency → επίκτητη αγαμμασφαιριναιμία, επίκτητη υπογαμμασφαιριναιμία, κοινή ποικίλλουσα ... common variable unclassifiable immunodeficiency → επίκτητη αγαμμασφαιριναιμία, επίκτητη υπογαμμασφαιριναιμία, κοινή ποικίλλουσα ... common variable unclassifiable immunodeficiency → επίκτητη αγαμμασφαιριναιμία, επίκτητη υπογαμμασφαιριναιμία, κοινή ποικίλλουσα ... common variable unclassifiable immunodeficiency → επίκτητη αγαμμασφαιριναιμία, επίκτητη υπογαμμασφαιριναιμία, κοινή ποικίλλουσα ...

https://www.translatum.gr/forum/index.php?topic=1003440.0

The ERS-education website provides centralised access to all educational material produced by the European Respiratory Society. It is the worlds largest CME collection for lung diseases and treatment offering high quality e-learning and teaching resources for respiratory specialists. This distance learning portal contains up-to-date study material for the state-of-the-art in Pulmonology.

https://dev.ers-education.org/lr/show-details/?idP=237428

We use cookies to ensure that we give you the best experience on our website. If you click Accept all cookies well assume that you are happy to receive all cookies and you wont see this message again. If you click Reject all non-essential cookies only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click Find out more for information on how to change your cookie settings. ...

https://www.ndm.ox.ac.uk/publications/588953

Whole-Genome Sequencing of Serially Collected Haemophilus influenzae From a Patient With Common Variable Immunodeficiency ... Whole-Genome Sequencing of Serially Collected Haemophilus influenzae From a Patient With Common Variable Immunodeficiency ...

https://app.cristin.no/results/show.jsf?id=2028966

Title : West Nile Virus Meningitis in Patient with Common Variable Immunodeficiency Personal Author(s) : Alonto, Augusto M.; ...

https://stacks.cdc.gov/view/cdc/14294

Wanchu A, Sud A, Bambery P, Singh S, Dutta U, Varma S. Common variable immunodeficiency in an adult. The Indian Journal of ... In this report, we describe a young male who had common variable immunodeficiency. He was treated with intravenous ... Primary immunodeficiency syndromes are rarely diagnosed among adults. ...

https://imsear.searo.who.int/handle/123456789/30281

The common immunologic defect in patients with common variable immunodeficiency is defective antibody formation. As is expected ... Common variable immunodeficiency has been reported in many different races. Common variable immunodeficiency equally affects ... encoded search term (Pediatric Common Variable Immunodeficiency) and Pediatric Common Variable Immunodeficiency What to Read ... infection has been reported in patients with common variable immunodeficiency. These cases indicate that common variable ...

https://www.staging.medscape.com/answers/885935-190792/what-are-the-signs-and-symptoms-of-common-variable-immunodeficiency-cvid

Common variable immunodeficiency (CVID) is a disorder that involves the following: (1) low levels of most or all of the ... encoded search term (Common Variable Immunodeficiency) and Common Variable Immunodeficiency What to Read Next on Medscape ... Common Variable Immunodeficiency Treatment & Management. Updated: Jun 08, 2022 * Author: Robert A Schwartz, MD, MPH; Chief ... Common variable immunodeficiency (CVID) in a family: an autosomal dominant mode of inheritance. Neth J Med. 2001 Sep. 59(3):134 ...

https://emedicine.staging.medscape.com/article/1051103-treatment

Common variable immunodeficiency is the most commonly seen primary immune deficiency condition in adults, characterized by ... The main cause of death in patients with common variable immunodeficiency is chronic lung diseases or malignancies, because ... The patient is diagnosed with common variable immunodeficiency by recurrent bacterial infections usually accompanied by chronic ...

https://avesis.istanbul.edu.tr/yayin/e17f5a3a-4985-409a-8ddc-b0be2d7c2ae2/common-variable-immunodeficiency

Common variable immune deficiency (CVID) is a disorder that impairs the immune system. Explore symptoms, inheritance, genetics ... Genetic Testing Registry: Common variable immunodeficiency 7 *Genetic Testing Registry: Common variable immunodeficiency 8, ... medlineplus.gov/genetics/condition/common-variable-immune-deficiency/ Common variable immune deficiency. ... Genetics of common variable immunodeficiency: role of transmembrane activator and calcium modulator and cyclophilin ligand ...

https://medlineplus.gov/genetics/condition/common-variable-immune-deficiency

Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by impaired immunoglobulin production and ... Noninfectious complications in patients with pediatric-onset common variable immunodeficiency correlated with defects in ... Noninfectious complications in patients with pediatric-onset common variable immunodeficie ...

https://pesquisa.bvsalud.org/portal/resource/pt/mdl-27713077

https://wwwnc-origin.cdc.gov/eid/article/9/10/03-0195

Keywords: Complementary and alternative medicine, Common variable immunodeficiency, Immunodeficiency, TURKISH CANCER-PATIENTS, ... The aim of this study was to investigate the rate of CAM usage in patients with common variable immunodeficiency (CVID). ... The use of complementary and alternative medicine in patients with common variable immunodeficiency. ... but there are no data on CAM usage in immunodeficiency diseases necessitating intravenous immunoglobulin (IVIG) therapy. ...

https://avesis.uludag.edu.tr/yayin/68ef326b-1520-4b1f-bf82-89fd12fb3e4b/the-use-of-complementary-and-alternative-medicine-in-patients-with-common-variable-immunodeficiency

Common variable immunodeficiency *Severe combined immunodeficiency syndrome (SCID). *Wiskott-Aldrich syndrome. Acquired ...

https://www.nhlbi.nih.gov/health/lymphopenia/causes

Some cases of common variable immunodeficiency may be due to a mutation in the SBDS gene of Shwachman-Diamond syndrome. Clin ... T and B lymphocyte abnormalities in bone marrow biopsies of common variable immunodeficiency. Blood 2011;118: 309-18.. ... A Patient with Common Variable Immunodeficiency Followed by Severe Aplastic Anemia Successfully Treated with Allogenic Stem ... Common variable immunodeficiency (CVID) is a heterogeneous group of primary immune disorders presented with a defective ...

https://jsms.sch.ac.kr/journal/view.php?number=330

Persistent middle ear effusion presumably biofilm-related in a paediatric patient with common variable immunodeficiency ... This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. ...

http://journals.seedmedicalpublishers.com/index.php/cmi/article/view/621/697

"Common variable immunodeficiency: Challenges for diagnosis". Wang LA, Abbott JK. Wang LA, et al. Among authors: abbott jk. J ... Common Variable Immunodeficiency: Diagnosis, Management, and Treatment. Abbott JK, Gelfand EW. Abbott JK, et al. Immunol ... Registries are shaping how we think about primary immunodeficiency diseases. Abbott JK, Gelfand EW. Abbott JK, et al. J Allergy ...

https://pubmed.ncbi.nlm.nih.gov/?cmd=search&term=Abbott+JK%5Bau%5D&dispmax=50

ALPS, autoimmune lymphoproliferative syndrome; CVID, common variable immunodeficiency; EBV, Epstein-Barr virus; HSCT, ... 16 patients had biallelic mutations in LRBA revealed by targeted re-sequencing of 77 common variable immunodeficiency (CVID)- ... Primary immunodeficiencies (PIDs) are genetic disorders of the immune system with heterogeneous and variable clinical ... The LRBA flow cytometry assay has been used for 3 years as a routine test at the Center for Chronic Immunodeficiency in ...

https://www.frontiersin.org/articles/10.3389/fimmu.2018.00720/full

There are no reports to date of vitamin E deficiency in patients with primary immunodeficiencies. We describe two CVID patients ... Adult, Common Variable Immunodeficiency, Female, Humans, Male, Middle Aged, Nervous System Diseases, Vitamin E Deficiency ... Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature ... Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature ...

https://www.stemcells.ox.ac.uk/publications/66445

Increased malignancy incidence in IgE deficient patients not due to concomitant Common Variable Immunodeficiency. ... Increased malignancy incidence in IgE deficient patients not due to concomitant Common Variable Immunodeficiency. Together ...

https://einstein.pure.elsevier.com/en/publications/increased-malignancy-incidence-in-ige-deficient-patients-not-due-/fingerprints/

... evidence favoring immunoglobulin treatment of a chronic norovirus infection in a patient with common variable immunodeficiency. ...

https://m.amedeo.com/35255136

common variable immunodeficiency (CVID). *undefined primary antibody deficiency on immunoglobulin (or eligible for Ig) ... primary immunodeficiency associated with impaired type I interferon signalling. *x-linked agammaglobulinaemia (and other ... severe Combined Immunodeficiency (SCID). *autoimmune polyglandular syndromes/autoimmune polyendocrinopathy, candidiasis, ... any person with a secondary immunodeficiency receiving or eligible for, immunoglobulin replacement therapy ...

https://www.nhsinform.scot/illnesses-and-conditions/infections-and-poisoning/coronavirus-covid-19/coronavirus-covid-19-treatments/

Multivariate classification comprises discriminant analysis and class-modeling techniques where multiple spectral variables are ... New approach to investigate common variable immunodeficiency patients using spectrochemical analysis of blood. Sci. Rep. 9, ... Identifying variables responsible for clustering in discriminant analysis of data from infrared microspectroscopy of a ... Ferrés, M., Platikanov, S., Tsakovski, S. & Tauler, R. Comparison of the variable importance in projection (VIP) and of the ...

https://www.nature.com/articles/s41596-020-0322-8?utm_campaign=related_content&utm_source=MTHDS&utm_medium=communities&error=cookies_not_supported&code=b073013a-c7f6-4ffb-8fb0-4ee50996079d

Somatically mutated clonal T cells in common variable immunodeficiency and related immunodeficiencies (845 Online Views) ... Immunodeficiency. Somatic mutations and T-cell clonality in patients with immunodeficiency (2542 Online Views) Paula Savola, ...

https://haematologica.org/issue/view/376

Patients With Common Variable Immunodeficiency (CVID) Show Higher Gut Bacterial Diversity and Levels of Low-Abundance Genes ... Bacterial and fungal gut microbiota analysis in common variable immunodeficiency (CVID) disorders: paired case-control study ... Bacterial but Not Fungal Gut Microbiota Alterations Are Associated With Common Variable Immunodeficiency (CVID) Phenotype ...

https://www.muni.cz/en/people/106498-juraj-bosak/publications

Common variable immunodeficiency, osteoporosis, Nocardia pneumonia. Streptococcus pneumoniae (12 days). Acute infection ... This may be an important mechanism as pseudomonas infection represents a common problem in lung transplant recipients. Previous ...

https://www.atsjournals.org/doi/10.1164/rccm.200212-1424BC

Five distinct clinical phenotypes have been delineated for common variable immunodeficiency (CVID): no complications, autoimmunity, polyclonal lymphocytic infiltration, enteropathy, and lymphoid malignancy. (medscape.com)
Splenomegaly and generalized lymphadenopathy are present in many patients with common variable immunodeficiency (CVID). (medscape.com)
In September 2002, during a WNV epidemic in Michigan ( 2 ), a 38-year-old woman with common variable immunodeficiency (CVID) sought treatment at the University of Michigan Hospital with acute WNV-associated meningitis. (cdc.gov)
Common variable immunodeficiency (CVID), one of the most prevalent primary immunodeficiency diseases, is a heterogeneous group of immunologic disorders of unknown etiology. (medscape.com)
Common variable immunodeficiency (CVID) patients were divided into four distinct clusters correlating to perceived health, a potentially important factor in providing care. (medscape.com)
The mainstay of treatment for common variable immunodeficiency (CVID) is Ig replacement therapy. (medscape.com)
Common variable immune deficiency (CVID) is a disorder that impairs the immune system. (medlineplus.gov)
Pneumonia is common in people with CVID. (medlineplus.gov)
Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by impaired immunoglobulin production and usually presents with a normal quantity of peripheral B cells . (bvsalud.org)
The aim of this study was to investigate the rate of CAM usage in patients with common variable immunodeficiency (CVID). (uludag.edu.tr)
A twenty-year-old male was diagnosed with common variable immunodecifiency (CVID) according to decreased blood level of immunoglobulins along with a history of recurrent sinopulmonary infection since early childhood, no response to prior vaccination, and the absence of all other defined immunodeficiency. (sch.ac.kr)
Common variable immunodeficiency (CVID) is a heterogeneous group of primary immune disorders presented with a defective immunoglobulin production with impaired immune response. (sch.ac.kr)
Although there is no perfect consensus on the diagnostic criteria of CVID, it is usually defined when a patient has (1) markedly reduced serum immunoglobulin G (IgG) with low levels of immunoglobulin A (IgA), and/or immunoglobulin M (IgM), (2) poor or absent antibody response to infection or immunization, and (3) an absence of any other immunodeficiency state or secondary cause of hypogammoglobulinemia [ 1 ]. (sch.ac.kr)
Recurrent infection is the most common manifestation of patients with CVID and sinopulmonary infection is observed in the majority of patients [ 1 , 4 ]. (sch.ac.kr)
The study included participants with common variable immunodeficiency (CVID), which is rarely monogenic. (cdc.gov)
But that's often not the case for people who suffer from common variable immunodeficiency (CVID), a group of rare disorders that increase the risk of life-threatening bacterial infections of the lungs, sinuses, and intestines. (nih.gov)
Predominantly antibody deficiencies such as common variable immunodeficiency (CVID). (allergy.org.au)
Mr. Lage has common variable immunodeficiency, or CVID, a genetic condition that prevents his body from producing antibodies to fight illnesses. (blogspot.com)
Recently completed molecular studies of poliovirus isolates suggest that viral replication of vaccine-related polioviruses may have persisted for as long as 7 years in a patient with vaccine-associated paralytic poliomyelitis (VAPP) in whom common variable immunodeficiency syndrome (CVID) previously had been diagnosed. (cdc.gov)
Differential diagnoses include autosomal recessive or dominant agammaglobulinemia, common variable immunodeficiency (CVID), hyper IgM syndrome and severe combined immunodeficiency (SCID) (see these terms). (orpha.net)

Combined immunodeficiencies such as severe combined immunodeficiency (SCID). (allergy.org.au)
The heterogeneous group of disorders involving the T-cell arm of the adaptive system, such as severe combined immunodeficiency (SCID), require immune reconstitution as soon as possible. (biomedcentral.com)
Examples include combined granulomatous disorder, SCID, common variable immunodeficiency. (who.int)
In this combined immunodeficiency (SCID) cancer is low in these species (as it chapter, some aspects of this issue mice, in which the human target is in humans), which renders cancer are discussed. (who.int)

B- and T-cell) immunodeficiency disorder ( 6 ). (cdc.gov)
variable immunodeficiency disorder. (cdc.gov)
Primary immunodeficiency disorder (PID) refers to a heterogeneous group of over 130 disorders that result from defects in immune system development and/or function. (biomedcentral.com)
Primary immunodeficiency disorder (PID) refers to a heterogeneous group of disorders characterized by poor or absent function in one or more components of the immune system. (biomedcentral.com)
A clinically variable form of isolated agammaglobulinemia, an inherited immunodeficiency disorder, characterized in affected males by recurrent bacterial infections during infancy. (orpha.net)
Chédiak-Higashi syndrome (CHS) is an autosomal recessive immunodeficiency disorder characterized by abnormal intracellular protein transport. (medscape.com)
however, immunocompromised immunocompromised A human or animal whose immunologic mechanism is deficient because of an immunodeficiency disorder or other disease or as the result of the administration of immunosuppressive drugs or radiation. (lecturio.com)
Iron deficiency anemia is the most common hematological disorder. (ijdr.in)

Patients with agammaglobulinemia, either common variable or X-linked, are known to be susceptible to recurrent infections ( 3 ). (cdc.gov)
Colonel Bruton's kinase defined the molecular basis of X-linked agammaglobulinemia, the first primary immunodeficiency. (medscape.com)

Common variable immunodeficiency is the most common severe antibody deficiency affecting both invent and adults. (modegame.online)
X-linked severe congenital neutropenia is an immunodeficiency syndrome characterized by recurrent major bacterial infections, severe congenital neutropenia, and monocytopenia. (rareprimarycarenews.com)

Patients come to medical attention due to infectious diseases at the time of onset, the most common being otitis media, diarrhea, pneumonia, and sinusitis. (medscape.com)
The patient is diagnosed with common variable immunodeficiency by recurrent bacterial infections usually accompanied by chronic lung diseases, gastrointestinal/liver diseases, granulomatous diseases, autoimmunity, lymphoid hyperplasia, splenomegaly or malignancies. (istanbul.edu.tr)
The main cause of death in patients with common variable immunodeficiency is chronic lung diseases or malignancies, because acute bacterial infections is usually prevented by IVIG therapy. (istanbul.edu.tr)
Objectives: Complementary and alternative medicine (CAM) usage is a reality in patients with chronic diseases, but there are no data on CAM usage in immunodeficiency diseases necessitating intravenous immunoglobulin (IVIG) therapy. (uludag.edu.tr)
Registries are shaping how we think about primary immunodeficiency diseases. (nih.gov)
Primary immunodeficiency diseases (PI) can affect a single component of the immune system or multiple cells and proteins. (primaryimmune.org)
PIDs are different from acquired immunodeficiencies (also known as secondary immunodeficiencies), which may be due to malignancy, cancer treatments, immunosuppressive medications, autoimmune diseases, or infections such as the human immunodeficiency virus (HIV), which causes acquired immunodeficiency syndrome (AIDS). (allergy.org.au)
Granulomatous lung diseases are a heterogeneous group of disorders that have a wide spectrum of pathologies with variable clinical manifestations and outcomes. (ersjournals.com)
As infection is a common cause of pulmonary granulomas, it is always important to exclude infectious lung diseases. (ersjournals.com)
Diseases were classified according to the International Classification of Disease, 9th revision, Clinical Modification (ICD-9-CM). HSD population is comparable with the Italian population surveyed by the Italian National Institute of Statistics (ISTAT) for the following variables: gender, age, and geographical location. (biomedcentral.com)
Hepatitis B is one of the most common infectious diseases in China. (biomedcentral.com)

Immunodeficiency-associated VDPVs (iVDPVs) are isolated of intestinal infection with poliovirus and prolonged viral from persons with primary immunodeficiency (PID). (cdc.gov)
Clinical and in-vitro evidence favoring immunoglobulin treatment of a chronic norovirus infection in a patient with common variable immunodeficiency. (amedeo.com)
Primary immunodeficiencies (PI) are a group of more than 400 genetic disorders that alter the ability of the immune system to fight off infection and affect 1 out of 1,200 1 births in the United States. (cdc.gov)
Ribavirin-resistant chronic norovirus infection-associated enteropathy in common variable immunodeficiency. (amedeo.com)
Although the clinical manifestations of PIDs are highly variable, most disorders involve at least an increased susceptibility to infection. (biomedcentral.com)
H. capsulatum is the most common endemic fungal infection in the US and is most prevalent in the midwestern and central states along the Ohio and Mississippi River valleys. (lecturio.com)

Common Variable Immunodeficiency: Diagnosis, Management, and Treatment. (nih.gov)
The most common underlying genetic diagnosis is autoimmune lymphoproliferative syndrome (ALPS) . (uniklinik-freiburg.de)
Due to their rarity, delay in the diagnosis of PID is common, increasing the risk of further complications and reduced survival rates. (allergy.org.au)
THI is a diagnosis of exclusion that occurs in the absence of other primary immunodeficiencies. (medscape.com)

Primary immunodeficiencies (PIDs) are genetic disorders of the immune system with heterogeneous and variable clinical phenotypes. (frontiersin.org)
Bronchiectasis represents the final common pathway of a number of infectious, genetic, autoimmune, developmental and allergic disorders and is highly heterogeneous in its aetiology, impact and prognosis. (ersjournals.com)
T-cell, B-cell or combined immunodeficiencies) or of innate immunity (e.g., phagocyte and complement disorders). (biomedcentral.com)
Ig replacement therapy is the mainstay of therapy for B-cell disorders, and is also an important supportive treatment for many patients with combined immunodeficiency disorders. (biomedcentral.com)
The treatment of innate immunodeficiency disorders varies depending on the type of defect, but may involve antifungal and antibiotic prophylaxis, cytokine replacement, vaccinations and bone marrow transplantation. (biomedcentral.com)
Orofacial petechiae, conjunctivae hemorrhage, nose-bleeding, spontaneous and post-traumatic gingival hemorrhage and prolonged post-extraction bleeding are common orofacial manifestations of inherited hemostatic disorders such as von Willebrand's disease and hemophilia. (ijdr.in)

Common variable immunodeficiency is the most commonly seen primary immune deficiency condition in adults, characterized by impaired B cell differentiation. (istanbul.edu.tr)
Vitamin E deficiency induced neurological disease in common variable immunodeficiency: two cases and a review of the literature of vitamin E deficiency. (ox.ac.uk)
There are no reports to date of vitamin E deficiency in patients with primary immunodeficiencies. (ox.ac.uk)
IgA deficiency is the most common PID, occurring in approximately 1 in 300 to 1 in 500 persons [ 4 ]. (biomedcentral.com)
Selective immunoglobulin A (IgA) deficiency is a relatively mild genetic immunodeficiency . (bionity.com)

Primary immunodeficiencies (PIDs), also known as inborn errors of immunity, are a diverse group of more than 400 potentially serious, chronic illnesses due to inherited absence or dysregulation of parts of the immune system. (allergy.org.au)
For the purpose of this document, the more readily recognised term of primary immunodeficiencies (PIDs) is used. (allergy.org.au)
It is important to note that PIDs are distinct from secondary immunodeficiencies that may result from other causes, such as viral or bacterial infections, malnutrition, or treatment with drugs that induce immunosuppression. (biomedcentral.com)

The common immunologic defect in patients with common variable immunodeficiency is defective antibody formation. (medscape.com)
One such antibody common in people with PLAID is known as antinuclear antibody (ANA). (medlineplus.gov)
It is the most common of the primary antibody deficiencies. (bionity.com)

Clinical and immunological overlap between autoimmune lymphoproliferative syndrome and common variable immunodeficiency, Clin Immunol. (uniklinik-freiburg.de)

Heterogeneous group of immunodeficiency syndromes characterized by hypogammaglobulinemia of most isotypes, variable B-cell defects, and the presence of recurrent bacterial infections. (bvsalud.org)

ABSTRACT This research was undertaken to evaluate the relationship between noncognitive variables and senior school achievement in geography. (afribary.com)
ABSTRACT Acquired Immunodeficiency Syndrome (AIDS) remains a major health challenge world over. (afribary.com)

Primary immunodeficiency syndromes are rarely diagnosed among adults. (who.int)

This document is a source for ASCIA IRT e-training for health professionals which is available at https://immunodeficiency.ascia.org.au This e-training course was developed as part of the National Prescribing Service (NPS) MedicineWise ViP Immunoglobulin project. (allergy.org.au)
This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (panafrican-med-journal.com)

Earlier studies suggested a primary B-lymphocyte defect as a cause of common variable immunodeficiency in a small group of patients. (medscape.com)
Noninfectious complications in patients with pediatric-onset common variable immunodeficiency correlated with defects in somatic hypermutation but not in class-switch recombination. (bvsalud.org)
The use of complementary and alternative medicine in patients with common variable immunodeficiency. (uludag.edu.tr)
Lysosomes of leukocytes and fibroblasts, dense bodies of platelets, azurophilic granules of neutrophils, and melanosomes of melanocytes are generally larger in size and irregular in morphology, indicating that a common pathway in the synthesis of organelles responsible for storage is affected in patients with CHS. (medscape.com)
Health-related quality of life in common variable immunodeficiency italian patients switched to remote assistance during the COVID-19 pandemic. (bvsalud.org)
In addition to today's regulatory milestones, an application to approve the new dispersible tablet of the fixed dose combination of abacavir, dolutegravir and lamivudine for the treatment of paediatric patients with human immunodeficiency virus type 1 (HIV-1) and to extend the current approved Marketing Authorisation of Triumeq tablets to include a paediatric indication for children is currently under review by the European Medicines Agency (EMA). (gsk.com)

The basic and common immunologic defect in common variable immunodeficiency is a failure of B-lymphocyte differentiation into plasma cells that produce the various immunoglobulin (Ig) isotypes. (medscape.com)
It is the most common type of immunoglobulin in newborns and, and her partner did not use condoms. (modegame.online)

For those with and without other immunodeficiency and children with immune globulin hbig to all methods of mechan-ical ventilation, several variables are independent, whereas the delirious patient may be stopped once k+ levels are elevated. (aaan.org)

Objectives To describe the methods used in the Demographic and Health Surveys (DHS) to collect nationally representative data on the prevalence of human immunodeficiency virus (HIV) and assess the value of such data to country HIV surveillance systems. (who.int)
Reliable data on the spread of human than a dozen are in various stages of General survey methodology immunodeficiency virus (HIV) and its implementation. (who.int)
One important factor is the introduction of the human immunodeficiency virus (HIV) into areas and populations already having a high TB incidence [ 5 ], the resulting double infections having a disastrous effect. (intechopen.com)
In addition, a supplemental new drug application (sNDA) has been approved for Triumeq tablet, lowering the minimum weight that a child with human immunodeficiency virus type 1 (HIV-1) can be prescribed this medicine to 25kgs from 40kgs. (gsk.com)
Evaluation of on-line high-performance size-exclusion chromatography, differential refractometry, and multi-angle laser light scattering analysis for the monitoring of the oligomeric state of human immunodeficiency virus vaccine protein antigen. (nchu.edu.tw)

Concomitant medication polypharmacy, interactions and imperfect adherence are common in Australian adults on suppressive ART. (monashhealth.org)

Ear infections are common in early childhood but are more likely due to anatomic defects than humoral immune defects. (medscape.com)

How common is bronchiectasis? (ersjournals.com)
It is reasonable to assume that bronchiectasis epidemiology might be variable and local data would be needed to define national policy priorities and to guide research and development activities for new drugs. (biomedcentral.com)

Late presentation was common with 9.6 days (range 1-21 days) being the average duration between the onset of symptoms and presentation at the hospital. (annalsafrmed.org)

Diarrhea is not a common symptom of gastrointestinal malignancy. (medscape.com)

The case described in this report is exceptional because it is the only known VAPP case in an immunodeficient person in which immunodeficiency had been diagnosed before onset of paralytic manifestations (5). (cdc.gov)

Raised Serum Markers of T Cell Activation and Exhaustion in Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency. (uio.no)
The term granulomatous lung disease does not refer to a specific disease entity, but to a wide spectrum of pathologies with variable clinical manifestations and outcomes. (ersjournals.com)

Prevalence varies by population, but is on the order of 1 in 500 to 1 in 800 people, making it relatively common for a genetic disease. (bionity.com)
To estimate the effects of non-response, HIV prevalence among non-responding males and females was predicted using multivariate statistical models for those who were tested, with a common set of predictor variables. (who.int)
Rare disease population data is recognized to be highly variable, and based on a wide variety of source data and methodologies, so the prevalence data on this site should be assumed to be estimated and cannot be considered to be absolutely correct. (rareprimarycarenews.com)

We see it would be demanding to find an appropriate parametric model for viral weight trajectories-the variable is generally measured at different time points for different subjects and the imply structure is definitely hard to model. (healthanddietblog.info)

IMSEAR at SEARO: Common variable immunodeficiency in an adult. (who.int)

Neurologic involvement is variable but often includes peripheral neuropathy. (medscape.com)

Anatomy6

Organisms2

Diseases21

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes7

In vivo modulation of cytokine synthesis by intravenous immunoglobulin. (1/340)

HLA class II homozygosity confers susceptibility to common variable immunodeficiency (CVID). (2/340)

Gastric pathology in patients with common variable immunodeficiency. (3/340)

Effect of IVIG on the hair regrowth in a common variable immune deficiency patient with alopecia universalis. (4/340)

Identification of a subset of common variable immunodeficiency patients with impaired B-cell protein tyrosine phosphorylation. (5/340)

Up-regulation of IL-12 in monocytes: a fundamental defect in common variable immunodeficiency. (6/340)

Lymphoid interstitial pneumonitis associated with common variable hypogammaglobulinaemia treated with cyclosporin A. (7/340)

Long-term outcome of chronic hepatitis C virus infection in primary hypogammaglobulinaemia. (8/340)

Common Variable Immunodeficiency

Agammaglobulinemia

IgA Deficiency

IgG Deficiency

Immunologic Deficiency Syndromes

Immunoglobulins, Intravenous

Dysgammaglobulinemia

Transmembrane Activator and CAML Interactor Protein

Bronchiectasis

B-Lymphocytes

Immunoglobulins

B-Lymphocyte Subsets

Splenomegaly

Aortic Arch Syndromes

Immunoglobulin M

Pseudolymphoma

T-Lymphocytopenia, Idiopathic CD4-Positive

Lymphocyte Activation

Complement C4a

Immunoglobulin Class Switching

Granuloma

Immunoglobulin G

Tumor Necrosis Factor Ligand Superfamily Member 13

T-Lymphocytes

Immunophenotyping

Immunoglobulin A

Opportunistic Infections

HIV-1

Antigens, CD27

Immunologic Memory

Cardiovascular Abnormalities

Interleukin-2

Lymphocyte Count

Anemia, Hemolytic, Autoimmune

Lung Diseases, Interstitial

Acquired Immunodeficiency Syndrome

Simian immunodeficiency virus

CD4-CD8 Ratio

Autoimmunity

Splenectomy

CD4-Positive T-Lymphocytes

Infection

Antibody Formation

Antigens, CD

T-Lymphocyte Subsets

Flow Cytometry

Respiratory Tract Infections

Lymphoproliferative Disorders

Lymphocyte Subsets

HIV Infections

In vivo modulation of cytokine synthesis by intravenous immunoglobulin. (1/340)

HLA class II homozygosity confers susceptibility to common variable immunodeficiency (CVID). (2/340)

Gastric pathology in patients with common variable immunodeficiency. (3/340)

Effect of IVIG on the hair regrowth in a common variable immune deficiency patient with alopecia universalis. (4/340)

Identification of a subset of common variable immunodeficiency patients with impaired B-cell protein tyrosine phosphorylation. (5/340)

Up-regulation of IL-12 in monocytes: a fundamental defect in common variable immunodeficiency. (6/340)

Lymphoid interstitial pneumonitis associated with common variable hypogammaglobulinaemia treated with cyclosporin A. (7/340)

Long-term outcome of chronic hepatitis C virus infection in primary hypogammaglobulinaemia. (8/340)

Common Variable Immune Deficiency (CVID)|Recovery|Prognosis|Prevention

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Lymphocyte Immunophenotyping in Common Variable Immunodeficiency - Full Text View - ClinicalTrials.gov

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Supervisors - ICAT

Immunosuppressive therapy with rituximab in common variable immunodeficiency | Clinical and Molecular Allergy | Full Text

Bronchiectasis in Patients with the Common Variable Immunodeficiency (CVID)

Chest Complications in Patients with Primary Antibody Deficiency Syndromes (PADS) | Springer for Research & Development

Resource Links & Documents

Immunodeficiency 7, Tcr-Alpha/beta Deficient disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials