The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.
Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in human and other male-heterogametic species.
Math calculations done for preparing appropriate doses of medicines, taking into account conversions of WEIGHTS AND MEASURES. Mistakes are one of the sources of MEDICATION ERRORS.
Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)
The giving of drugs, chemicals, or other substances by mouth.
Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.
Genes that are located on the X CHROMOSOME.
The homologous chromosomes that are dissimilar in the heterogametic sex. There are the X CHROMOSOME, the Y CHROMOSOME, and the W, Z chromosomes (in animals in which the female is the heterogametic sex (the silkworm moth Bombyx mori, for example)). In such cases the W chromosome is the female-determining and the male is ZZ. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
A dosage compensation process occurring at an early embryonic stage in mammalian development whereby, at random, one X CHROMOSOME of the pair is repressed in the somatic cells of females.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
Therapy with two or more separate preparations given for a combined effect.
Injections made into a vein for therapeutic or experimental purposes.
Hard or soft soluble containers used for the oral administration of medicine.
Elements of limited time intervals, contributing to particular results or situations.
A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
The process of observing, recording, or detecting the effects of a chemical substance administered to an individual therapeutically or diagnostically.
The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)
A species of fruit fly much used in genetics because of the large size of its chromosomes.
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
Genes whose loss of function or gain of function MUTATION leads to the death of the carrier prior to maturity. They may be essential genes (GENES, ESSENTIAL) required for viability, or genes which cause a block of function of an essential gene at a time when the essential gene function is required for viability.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.
Substances that reduce the growth or reproduction of BACTERIA.
In gonochoristic organisms, congenital conditions in which development of chromosomal, gonadal, or anatomical sex is atypical. Effects from exposure to abnormal levels of GONADAL HORMONES in the maternal environment, or disruption of the function of those hormones by ENDOCRINE DISRUPTORS are included.
Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.
Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.
The amount of radiation energy that is deposited in a unit mass of material, such as tissues of plants or animal. In RADIOTHERAPY, radiation dosage is expressed in gray units (Gy). In RADIOLOGIC HEALTH, the dosage is expressed by the product of absorbed dose (Gy) and quality factor (a function of linear energy transfer), and is called radiation dose equivalent in sievert units (Sv).
Forceful administration into a muscle of liquid medication, nutrient, or other fluid through a hollow needle piercing the muscle and any tissue covering it.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
Validation of the SEX of an individual by inspection of the GONADS and/or by genetic tests.
The long-term (minutes to hours) administration of a fluid into the vein through venipuncture, either by letting the fluid flow by gravity or by pumping it.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Processes occurring in various organisms by which new genes are copied. Gene duplication may result in a MULTIGENE FAMILY; supergenes or PSEUDOGENES.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects.
The action of a drug that may affect the activity, metabolism, or toxicity of another drug.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
An individual having different alleles at one or more loci regarding a specific character.
Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals.
Homogeneous liquid preparations that contain one or more chemical substances dissolved, i.e., molecularly dispersed, in a suitable solvent or mixture of mutually miscible solvents. For reasons of their ingredients, method of preparation, or use, they do not fall into another group of products.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
The chemical and physical integrity of a pharmaceutical product.
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.
Substances that destroy fungi by suppressing their ability to grow or reproduce. They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The chromosomal constitution of a cell containing multiples of the normal number of CHROMOSOMES; includes triploidy (symbol: 3N), tetraploidy (symbol: 4N), etc.
The possession of a third chromosome of any one type in an otherwise diploid cell.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
The functional hereditary units of INSECTS.
Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.
Drugs used to prevent SEIZURES or reduce their severity.
The administration of liquid medication, nutrient, or other fluid through some other route than the alimentary canal, usually over minutes or hours, either by gravity flow or often by infusion pumping.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Dynamic and kinetic mechanisms of exogenous chemical and DRUG LIBERATION; ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and DRUG TOXICITY as a function of dosage, and rate of METABOLISM. LADMER, ADME and ADMET are abbreviations for liberation, absorption, distribution, metabolism, elimination, and toxicology.
The human female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in humans.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Any method used for determining the location of and relative distances between genes on a chromosome.
An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
Any dummy medication or treatment. Although placebos originally were medicinal preparations having no specific pharmacological activity against a targeted condition, the concept has been extended to include treatments or procedures, especially those administered to control groups in clinical trials in order to provide baseline measurements for the experimental protocol.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The mechanisms by which the SEX of an individual's GONADS are fixed.
Proteins prepared by recombinant DNA technology.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.
A species of nematode that is widely used in biological, biochemical, and genetic studies.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
The rate dynamics in chemical or physical systems.
Mutation process that restores the wild-type PHENOTYPE in an organism possessing a mutationally altered GENOTYPE. The second "suppressor" mutation may be on a different gene, on the same gene but located at a distance from the site of the primary mutation, or in extrachromosomal genes (EXTRACHROMOSOMAL INHERITANCE).
Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
The use of DRUGS to treat a DISEASE or its symptoms. One example is the use of ANTINEOPLASTIC AGENTS to treat CANCER.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Pathological processes of the KIDNEY or its component tissues.
A sulfanilamide that is used as an anti-infective agent.
A small aquatic oviparous mammal of the order Monotremata found in Australia and Tasmania.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Use of written, printed, or graphic materials upon or accompanying a drug container or wrapper. It includes contents, indications, effects, dosages, routes, methods, frequency and duration of administration, warnings, hazards, contraindications, side effects, precautions, and other relevant information.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
RNA which does not code for protein but has some enzymatic, structural or regulatory function. Although ribosomal RNA (RNA, RIBOSOMAL) and transfer RNA (RNA, TRANSFER) are also untranslated RNAs they are not included in this scope.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
A class of untranslated RNA molecules that are typically greater than 200 nucleotides in length and do not code for proteins. Members of this class have been found to play roles in transcriptional regulation, post-transcriptional processing, CHROMATIN REMODELING, and in the epigenetic control of chromatin.
The measurement of an organ in volume, mass, or heaviness.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
The variable phenotypic expression of a GENE depending on whether it is of paternal or maternal origin, which is a function of the DNA METHYLATION pattern. Imprinted regions are observed to be more methylated and less transcriptionally active. (Segen, Dictionary of Modern Medicine, 1992)
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
An individual in which both alleles at a given locus are identical.
Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The chromosomal constitution of cells, in which each type of CHROMOSOME is represented twice. Symbol: 2N or 2X.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Agents that control agitated psychotic behavior, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect. They are used in SCHIZOPHRENIA; senile dementia; transient psychosis following surgery; or MYOCARDIAL INFARCTION; etc. These drugs are often referred to as neuroleptics alluding to the tendency to produce neurological side effects, but not all antipsychotics are likely to produce such effects. Many of these drugs may also be effective against nausea, emesis, and pruritus.
Samarium. An element of the rare earth family of metals. It has the atomic symbol Sm, atomic number 62, and atomic weight 150.36. The oxide is used in the control rods of some nuclear reactors.
A nitroimidazole antiprotozoal agent used in ameba and trichomonas infections. It is partially plasma-bound and also has radiation-sensitizing action.
The functional hereditary units of FUNGI.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A copy number variation that results in reduced GENE DOSAGE due to any loss-of-function mutation. The loss of heterozygosity is associated with abnormal phenotypes or diseased states because the remaining gene is insufficient.
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Substances that reduce or suppress INFLAMMATION.
In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.
Directions written for the obtaining and use of DRUGS.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.
Antibacterial obtained from Streptomyces orientalis. It is a glycopeptide related to RISTOCETIN that inhibits bacterial cell wall assembly and is toxic to kidneys and the inner ear.
Proteins from the nematode species CAENORHABDITIS ELEGANS. The proteins from this species are the subject of scientific interest in the area of multicellular organism MORPHOGENESIS.
A chromatography technique in which the stationary phase is composed of a non-polar substance with a polar mobile phase, in contrast to normal-phase chromatography in which the stationary phase is a polar substance with a non-polar mobile phase.
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
An infant during the first month after birth.
A plant genus of the family BRASSICACEAE. The common name of white mustard sometimes refers to other plants (MUSTARD PLANT).
A broad-spectrum antibiotic derived from KANAMYCIN. It is reno- and oto-toxic like the other aminoglycoside antibiotics.
Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
Agents that prevent clotting.
Errors in prescribing, dispensing, or administering medication with the result that the patient fails to receive the correct drug or the indicated proper drug dosage.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Forceful administration into the peritoneal cavity of liquid medication, nutrient, or other fluid through a hollow needle piercing the abdominal wall.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.
Administration of a soluble dosage form between the cheek and gingiva. It may involve direct application of a drug onto the buccal mucosa, as by painting or spraying.
The process in developing sex- or gender-specific tissue, organ, or function after SEX DETERMINATION PROCESSES have set the sex of the GONADS. Major areas of sex differentiation occur in the reproductive tract (GENITALIA) and the brain.
Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS.
A cardiotonic glycoside obtained mainly from Digitalis lanata; it consists of three sugars and the aglycone DIGOXIGENIN. Digoxin has positive inotropic and negative chronotropic activity. It is used to control ventricular rate in ATRIAL FIBRILLATION and in the management of congestive heart failure with atrial fibrillation. Its use in congestive heart failure and sinus rhythm is less certain. The margin between toxic and therapeutic doses is small. (From Martindale, The Extra Pharmacopoeia, 30th ed, p666)
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Structures within the CELL NUCLEUS of insect cells containing DNA.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
Drugs that are used to treat RHEUMATOID ARTHRITIS.
A methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE that degrades CYCLIC AMP thus potentiates the actions of agents that act through ADENYLYL CYCLASES and cyclic AMP.
Derivatives of acetamide that are used as solvents, as mild irritants, and in organic synthesis.
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.
Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.
A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid.
Determination, by measurement or comparison with a standard, of the correct value of each scale reading on a meter or other measuring instrument; or determination of the settings of a control device that correspond to particular values of voltage, current, frequency or other output.
Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.
System established by the World Health Organization and the International Committee on Thrombosis and Hemostasis for monitoring and reporting blood coagulation tests. Under this system, results are standardized using the International Sensitivity Index for the particular test reagent/instrument combination used.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.
A genus of small free-living nematodes. Two species, CAENORHABDITIS ELEGANS and C. briggsae are much used in studies of genetics, development, aging, muscle chemistry, and neuroanatomy.
Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.
A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
The study of the physical and chemical properties of a drug and its dosage form as related to the onset, duration, and intensity of its action.
Nucleoproteins, which in contrast to HISTONES, are acid insoluble. They are involved in chromosomal functions; e.g. they bind selectively to DNA, stimulate transcription resulting in tissue-specific RNA synthesis and undergo specific changes in response to various hormones or phytomitogens.
Use of plants or herbs to treat diseases or to alleviate pain.
Voluntary cooperation of the patient in following a prescribed regimen.
Includes detailed dosage information. (CS1: Julian-Gregorian uncertainty, All articles with dead external links, Articles with ... Accidental or deliberate overdose is common with opium tincture given the highly concentrated nature of the solution. Overdose ... Suicide by laudanum was common in the mid-19th century. Prudent medical judgment necessitates toward dispensing very small ... Media related to Laudanum at Wikimedia Commons Merck Prescribing Information for Laudanum/Opium Tincture. ...
Its dosages are between 1 and 2 mg/kg body weight with common dosage of 100 mg. The drug can only be kept under room ... The dosages range from 50 to 200 μg in adults. It has quick onset and quick elimination. The common side effect is reflex ... The dosage is between 0.03 and 0.07 mg/kg. A common side effect of this drug is bradycardia. Therefore, glycopyrrolate, an ... Myoclonus, pain at the site of the injection, post-operative nausea and vomiting are common. While common, the incidence and ...
Both prescription and non-prescription dosages of pills are always measured in the SI system with the most common unit being ... Smaller dosages use micrograms. Because the SI prefix μ (mu) is not well known among many Americans and is not available on ... 700 mL (23.6 fl oz) and one-liter sizes are also common, though 20 fl oz, and 24 fl oz sizes remain popular, particularly in ... In many respects, it has been superseded by the 3.5 mm connectors or 2.5 mm headset, which was common on older mobile phones. ...
The dosage is adjusted to each individual's response. The most common side effects are abdominal or pelvic pain, bloating, as ...
The common name "cone flower" comes from the characteristic center "cone" at the center of the flower head. The first Echinacea ... Drugsite (8 April 2021). "Echinacea Uses, Benefits & Dosage - Drugs.com Herbal Database". Drugs.com. New Zealand: Drugsite ... According to Wallace Sampson, its modern use for the common cold began when a Swiss herbal supplement maker was told that ... By the start of the 20th century it was the most common herbal remedy in America.[citation needed] Commercial cultivation began ...
It is a common native to the Eastern United States and Canada, widespread from Nova Scotia to Florida, west as far as Texas, ... "Boneset (Eupatorium perfoliatum L.) Uses, Benefits and Dosage". Drugs.com. 1 February 2019. Retrieved 4 March 2019. Hensel, ... Eupatorium perfoliatum, known as common boneset or just boneset, is a North American perennial plant in the family Asteraceae. ... Hilty, John (24 October 2018). "Common Boneset". Illinois Wildflowers. Retrieved 6 September 2022. " ...
"Smartweed: Uses, Side Effects, Interactions, Dosage, and Warning". www.webmd.com. Retrieved 2019-11-14. Wikimedia Commons has ... Persicaria bicornis is a North American species of flowering plant in the buckwheat family (Polygonaceae). The common name is ... Articles with short description, Short description matches Wikidata, Articles with 'species' microformats, Commons category ...
Common variations in the BCL9 gene, which is in the distal area, confer risk of schizophrenia and may also be associated with ... It is assumed to be a dosage-sensitive gene. When this gene is not available in the 1q21.1 area it leads to microcephaly. ... In case of a duplication of GJA5 tetralogy of Fallot is more common. In case of a deletion other congenital heart diseases than ... March 2011). "Common variants in the BCL9 gene conferring risk of schizophrenia". Arch. Gen. Psychiatry. 68 (3): 232-40. doi: ...
Very common (>10% incidence) adverse effects include sleepiness, tiredness, headache, and stomach ache. Common (1-10% incidence ... Increases in dosage can have the same adjustment period. Guanfacine availability is significantly affected by the CYP3A4 and ... Common side effects include sleepiness, constipation, and dry mouth. Other side effects may include low blood pressure and ... "Guanfacine , Side Effects, Dosage, Uses, and More". 11 November 2017. Roth, BL; Driscol, J (12 January 2011), "PDSP Ki Database ...
Due to the high cost of an omalizumab, and the concern over long-term safety, treatment is not yet very common, especially in ... Another barrier to wide use is its injectable dosage form. In August 2010, the National Institute for Clinical Excellence (NICE ...
The most common form of prenatal vitamin is the compressed tablet which is available through all channels and at various ... The increased dosage of folic acid or folates reflects the American Dietetic Associations position that women should consume " ... Often prenatal vitamins also have a reduced dosage of vitamins that may be detrimental to the fetus when taken in high doses ( ... Due to tolerance challenges, the prenatal vitamin industry has developed a multitude of dosage forms to meet the needs and ...
Symptoms typically emerge when dosage of the drug is reduced. GABA is the second-most-common neurotransmitter in the central ... which in turn may lead to dosage escalation, with one study finding 25% of patients escalated their dosage. Some authors, ... The time needed to withdrawal can vary from a couple of months to a year or more and often depends on length of use, dosage ... The next-most-common substance that elderly people develop a drug dependence to or misuse is benzodiazepines. Drug-induced ...
In middle age ointments were a common dosage form. Avicenna separates Medicine and Pharmacy, in 1025 published his book The ... Quattrocchi, Umberto (2012) CRC World Dictionary of Medicinal and Poisonous Plants: Common Names, Scientific Names, Eponyms, ...
Before the advent of medicine as a science, it was common for pharmacists to dispense drugs as is. Most drugs today are ... It is also called the science of dosage form design. There are many chemicals with pharmacological properties, but need special ... Pharmaceutics deals with the formulation of a pure drug substance into a dosage form. Branches of pharmaceutics include: ... Media related to Pharmaceutics at Wikimedia Commons Excipient selection for injectable / parenteral formulations v t e ( ...
Tablets, mini-tablets, pellets and granules (usually filled into capsule shells) are the most common enteric-coated dosage ... The time required for an enteric-coated dosage form to reach the intestine mostly depends on the presence and type of food in ... Although some studies indicated that larger sized dosage forms may require additional time for gastric emptying, others ... Enteric-coated medications pertain to the "delayed action" dosage form category. ...
They are commonly used in oral and topical pharmaceutical dosage forms. They are also often used in cosmetics to solubilize ... Common brand names for polysorbates include Kolliphor, Scattics, Alkest, Canarcel, and Tween. Polysorbate 20 (polyoxyethylene ( ...
Common examples include oral and intravenous administration. Routes can also be classified based on where the target of action ... FDA Center for Drug Evaluation and Research Data Standards Manual: Dosage Form. A.S.P.E.N. American Society for Parenteral and ... However, skin irritation may result, and for some forms such as creams or lotions, the dosage is difficult to control. Upon ... A suppository is a solid dosage form that fits for rectal administration. In hospice care, a specialized rectal catheter, ...
Gout is another common type of inflammatory arthritis that typically affects one joint at a time. Pharmacological treatment of ... The maximum recommended daily dosage for an adult is 4000 mg. In more severe cases of arthritic pain, opioids may be prescribed ... The common side effect of using JAK inhibitors is the increased susceptibility to infections. For example: Pneumonia and ... Common DMARDs include oral methotrexate, leflunomide, or sulfasalazine. Conventional DMARDs have a slow onset of action and can ...
These usually disappear on reducing the dosage or interrupting the treatment. Oxeladin differs from common antitussives that ... which are present when common antitussives, such as codeine and its derivatives, are used. It may be used at every age, as well ...
Anti-Fya is a common antibody while anti-Fyb is approximately 20 times less common., They are reactive at body temperature and ... They display dosage (react more strongly to homozygous cells versus heterozygous cells). Typically mild but may be serious, ... Asthma is more common and tends to be more severe in those of African descent. There appears to be a correlation with both ... Using these two antibodies, three common phenotypes were defined: Fy(a+b+), Fy(a+b-), and Fy(a-b+).[citation needed] Several ...
Some common dosage forms for the oral cavity include gels, ointments, patches, and tablets. Depending on the dosage form, some ... Gels, solutions, and aerosols are common dosage forms in the nasal cavity. However, recent research into particles and ... The retention of dosage forms in the bladder is relatively poor, which is related to the need for a periodical urine voiding. ... These dosage forms are commonly used to deliver drugs to the eye and nasal cavity. They often include mucoadhesive polymers to ...
Adult dosage is 5-10 ml up to 3-4 times daily. Pholcodine now largely replaces the previously more common codeine linctus, as ...
This is particularly common with powdered drugs such as cocaine or MDMA which can be mixed with relative ease by adding another ... The risk level will depend on the dosage level of both substances. If the drugs taken are illegal, they have a chance of being ... The most common psychoactive substances are alcohol, caffeine, cannabis, and nicotine (tobacco, and nicotine replacement ... A study among treatment admissions found that it is more common for younger people to report polysubstance use. Alcohol ...
These dosage forms possess different absorption mechanisms and consist of different active ingredients. Common active ...
The most common side-effects are fatigue (1.2%), dry mouth (3%), and headache (0.6%). Co-administration with erythromycin, ... Desloratadine is available in many dosage forms and under many trade names worldwide. An emerging indication for desloratadine ...
The effects of poisoning vary drastically depending on dosage and levels of exposure. The types of pesticides most often ... Certain fumigants, nematicides, herbicides, and dipyridyls are also common in cases of pesticide poisoning. One of the best ... The most common instances of pesticide misuse are applications inconsistent with the labeling, which can include the use of a ... but ecological researchers have found language barriers and illiteracy to be among the most common. Safety data sheets for ...
The most common cause of postpartum hemorrhage is a loss of muscle tone in the uterus. Normally, the uterus will contract to ... If this occurs, it can be managed by lowering the dosage of oxytocin. Hyponatremia is a decreased concentration of sodium in ... Common side effects of carbetocin include vomiting, fever, and hypertension- similar side effect profile to that of oxytocin. ... Its most common side effect is hypertension. Methylergonovine is recommended as a second-line therapy in treating postpartum ...
The usual dosage is 20-30 mg/kg/day divided into two doses. Common side effects include gastrointestinal disturbances such as ...
Some common synthetic cannabinoids are available in the market such as JWH-018, which is the most well-known Naphthoylindoles ... Both of which are available in the dosage forms of pills and tablets. Synthetic cannabinoids are naturally in solid and oil ... Common examples from these categories are phenethylamines, cannabinoids and benzodiazepines. To exert the psychoactive effect, ... The most common delivery routes of Alprazolam and Phenethylamine are by oral administration. ...
... dosage levels, study conditions, ... A common model used to synthesize heterogeneous research is the random effects model of ... The aim then is to use approaches from statistics to derive a pooled estimate closest to the unknown common truth based on how ... The distribution of effect sizes can be visualized with a funnel plot which (in its most common version) is a scatter plot of ... Other common approaches include the Mantel-Haenszel method and the Peto method. Seed-based d mapping (formerly signed ...
It is known from the clinical trials that the more common side effects for both vaccines can occur at a rate of more than one ... "Already produced 40-50 million dosages of Covishield vaccine, says Serum Institute". The Hindu (به انگلیسی). 28 December 2020. ... همهٔ نوشته‌ها تحت مجوز Creative Commons Attribution/Share-Alike در دسترس است؛ برای جزئیات بیشتر شرایط استفاده را بخوانید.. ...
Diabetes affects up to 1 in 230 cats,[1] and may be becoming increasingly common. Diabetes mellitus is less common in cats than ... Dosage and regulation[edit]. Cats may have their mealtimes strictly scheduled and planned to match with injection times, ... With some dosages, the insulin may not last long enough for the cat. Testing blood sugar more frequently can determine if the ... Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site ...
Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site ... mineral water required sending large barrels to individual boardinghouses where the patients drank physician-prescribed dosages ... and drives along quaint lanes where wild deer are as common as cows to us, and almost as unafraid".[8] ...
A matter of dosage". Science 298 (5594): 761-3. doi:10.1126/science.1077707. பப்மெட்:12399571. ... Mellemkjaer L, Hammarstrom L, Andersen V, et al. (2002). "Cancer risk among patients with IgA deficiency or common variable ...
UNIT 2 Measurement Systems: The Apothecary System». A: Math for Nurses: A Pocket Guide to Dosage Calculation and Drug ... A Wikimedia Commons hi ha contingut multimèdia relatiu a: Sistema Imperial d'Unitats. ... Dosage Calculations. 2a edició. Toronto: Nelson Education, 2012, p. 528. ISBN 978-0-17-650259-1. OCLC 693657704 [Consulta: 6 ... Dosage Calculation, Preparation and Administration. 6a edició. Philadelphia, PA: Wolters Kluwer Health Lippincott Williams & ...
One common system has a purpose-designed plastic "pressure bottle" pressurized with a large disposable plastic syringe. A ... Dosage forms. Hidden categories: *Articles needing additional references from September 2011. *All articles needing additional ... Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site ... Another common form is a set of fingers that press on the tube in sequence. ...
These structures aim to keep the drug intact until its site of action and release it at a correct dosage when exposed to a ... Amylopectin is the most common carbohydrate in the human diet and is contained in many staple foods. The major sources of ... Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site ...
Common name Geographic range[41]. Acrochordidae Bonaparte, 1831 1 3 Wart snakes Western India and Sri Lanka through tropical ... and cottonmouths is injected into the body of a horse in ever-increasing dosages until the horse is immunized. Blood is then ... Common name Geographic range[41]. Anomalepidae Taylor, 1939 4 18 Primitive blind snakes From southern Central America to ... One of the etymologies proposed for the common female first name Linda is that it might derive from Old German Lindi or Linda, ...
Miller E; Pastor-Barriuso R; Dalal D; Riemersma R; Appel L; Guallar E (2005). "Meta-analysis: high-dosage vitamin E ... Besedilo se sme prosto uporabljati v skladu z dovoljenjem Creative Commons Priznanje avtorstva-Deljenje pod enakimi pogoji 3.0 ...
Acquired agranulocytosis is much more common than the congenital form. The common causes of acquired agranulocytosis including ... due to increased dosage requirements of G-CSF or having abnormal precursor cells in the bone marrow) often require ... Fevers are a common and early observation. Sometimes overlooked is the presence of hypothermia, which can be present in sepsis ... Neutropenia itself is a rare entity, but can be clinically common in oncology[35] and immunocompromised individuals as a result ...
Text is available under the Creative Commons Attribution/Share-Alike License and the GFDL; additional terms may apply. See ... "Plasma thiamine concentrations after intramuscular and oral multiple dosage regimens in healthy men". European Journal of ...
Various forms of vitamin E are common food additive in oily food, used to deter rancidity caused by peroxidation. Those with an ... Miller ER, Pastor-Barriuso R, Dalal D, Riemersma RA, Appel LJ, Guallar E (January 2005). "Meta-analysis: high-dosage vitamin E ... Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site ... is the most common form found in the North American diet, but alpha-tocopherol (α-tocopherol) is the most biologically active.[ ...
In most of the New Latin names, Pharmacopoea is the more common spelling, although for several of them, Pharmacopoeia is common ... Medical preparations, uses, and dosages[edit]. A bottle of glycerin purchased at a pharmacy with the abbreviation I.P. ... proceed through stages of review and consultation leading to adoption of a common monograph that provides a common set of tests ... Until 1617, such drugs and medicines as were in common use were sold in England by the apothecaries and grocers. In that year ...
Other common forms of interference include antibody interference, cross-reactivity and signal interference. The phenomenon is ... Simple illustration of the effects of excess antigen and dosage response curve. ... Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site ...
Methylation of DNA is a common modification in mammalian cells. The cytosine base is methylated and becomes 5-methylcytosine, ... Proper histone dosage is important in yeast as shown from the extended lifespans seen in strains that are overexpressing ... Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site ... Similarly, skin wrinkles and other common changes seen with aging are not better indicators of future functionality than ...
In some special applications, depleted uranium or thorium[21] are used, but lead is much more common; several cm are often ... high concentrations of bone marrow to defer the hematopoietic sub-syndrome of Acute Radiation Syndrome to much higher dosages. ... Cosmic radiation is not a common concern on Earth, as the Earth's atmosphere absorbs it and the magnetosphere acts as a shield ... Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site ...
PAD is two times as common in males as females. In terms of ethnicity, PAD is more common in people of color compared to the ... The recommended daily dosage of aspirin for treating PAD is between 75 and 325 mg, while the recommended daily dosage for ... In 2015, about 155 million people had PAD worldwide.[13] It becomes more common with age.[25] In the developed world, it ... Peripheral arterial disease is more common in these populations:[38][46] *All people who have leg symptoms with exertion ( ...
Snow was one of the first to study dosages for the use of ether and chloroform as surgical anaesthetics. This let patients to ... Text is available under the Creative Commons Attribution/Share-Alike License and the GFDL; additional terms may apply. See ...
This is most common with type one diabetics, who may require several insulin injections a day.[22] It also occurs with patients ... Alexander Wood's main contribution was the all-glass syringe in 1851, which allowed the user to estimate dosage based on the ... Needles in common medical use range from 7 gauge (the largest) to 33 (the smallest). 21-gauge needles are most commonly used ... Walter Reginald Bett, The History and Conquest of Common Diseases p. 145 (1954) ...
The common features of global response are induction of multiple genes, cell cycle arrest, and inhibition of cell division. ... For example, increasing the gene dosage of the gene SIR-2, which regulates DNA packaging in the nematode worm Caenorhabditis ... A chart of common DNA damaging agents, examples of lesions they cause in DNA, and pathways used to repair these lesions. Also ... Tissenbaum HA, Guarente L (March 2001). "Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans". Nature. ...
Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site ... whose cannabis dosage was believed to be comparable to three marijuana cigarettes smoked daily, a "moderate" group that was ...
"Metoclopramide Side Effects: Common, Severe, Long Term". Drugs.com. Diakses tanggal 2020-06-24. ... "Metoclopramide: Uses, Dosage, Side Effects". Drugs.com. Diakses tanggal 2020-06-24 ... Téks ditangtayungan ku Creative Commons Attribution-ShareAlike License; katangtuan tambahan lianna bisa dilarapkeun ogé. Baca ... "Metoclopramide: Uses, Dosage, Side Effects". Drugs.com. Diakses tanggal 2020-06-23 ...
References for the image are found in Wikimedia Commons page at: Commons:File:Notable mutations.svg#References. ... Exceptions are when the organism is haploid, or when the reduced dosage of a normal gene product is not enough for a normal ... Less common is a transversion, which exchanges a purine for a pyrimidine or a pyrimidine for a purine (C/T ↔ A/G). An example ... One-third of all indigenous inhabitants of Sub-Saharan Africa carry the allele, because, in areas where malaria is common, ...
Oral dosage forms of methaqualone hydrochloride were manufactured as capsules, whereas oral dosage forms of methaqualone free- ... Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site ...
Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site ... in the measure of warfarin dosage, liver damage, and vitamin K status.[15] ... the rise in conjugated bilirubin is less than the complete common bile duct obstruction due to malignant causes. In Dubin- ...
For example, in the United Kingdom, the term pain dysfunction syndrome is in common use.[17] In the United States, the term ... Additionally, details of exercise, dosage, and frequency as well as details on manual techniques should be reported to create ... A common scenario where a newly placed dental restoration (e.g. a crown or a filling) is incorrectly contoured, and creates a ... Pain is the most common reason for people with TMD to seek medical advice.[2] Joint noises may require auscultation with a ...
Fines of several thousand yuan may follow.[145] Lu and Galli write that dosages of medication up to five or six times the usual ... has nothing in common with the socialist ethical and cultural progress we are striving to achieve."[74] Suppressing Falun Gong ... level are administered through a nasogastric tube as a form of torture or punishment, and that physical torture is common, ...
This study typically lasts several months and its purpose is to prove safety and an effective dosage. Phase II includes a ... Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site ...
"Aspirin monograph: dosages, etc". Medscape.com. Retrieved 11 May 2011.. *^ US Preventive Services Task Force (March 2009). " ... One common adverse effect is an upset stomach.[5] More significant side effects include stomach ulcers, stomach bleeding, and ... DosagesEdit. Adult aspirin tablets are produced in standardised sizes, which vary slightly from country to country, for example ... A study of a group with a mean dosage of aspirin of 270 mg per day estimated an average absolute risk increase in intracerebral ...
Common side effects of lisdexamfetamine include loss of appetite, anxiety, diarrhea, trouble sleeping, irritability, and nausea ... pharmaceutical amphetamines at therapeutic dosages appear to improve brain development and nerve growth.[23][24][25] Reviews of ... Text is available under the Creative Commons Attribution-ShareAlike License 3.0; additional terms may apply. By using this site ... Overall, the data suggest that ADHD medication misuse and diversion are common health care problems for stimulant medications, ...
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Common side effects include agitation, headache, and upset stomach. Serious side effects include suicidal thoughts, prolonged ... Common side effects. *The most common side effects of Seroquel or Seroquel XR are*headache, ... Less common side effects include seizures (1 in 125 patients) and hypothyroidism (1 in 250 patients). ... Common side effects include dizziness, drowsiness, and weight gain. Possible serious and important side effects include ...
Learn about warnings, side effects, dosage, and more for duloxetine oral capsule. ... More common side effects. In adults, the more common side effects of duloxetine can include:. *nausea ... Dosage for people younger than 13 years hasnt been established.. Dosage for chronic muscle and joint pain. Adult dosage (ages ... Dosage for people younger than 18 years hasnt been established.. Dosage for fibromyalgia. Adult dosage (ages 18 years and ...
Learn about side effects, dosage, warnings, and more. ... Common questions about Lucentis. Here are answers to some ... Dosage for diabetic macular edema. The usual dosage for people with diabetic macular edema (DME) is 0.3 mg of Lucentis in 0.05 ... Dosage for diabetic retinopathy. For diabetic retinopathy, the typical dosage is 0.3 mg of Lucentis in 0.05 mL of liquid ... Dosage for wet age-related macular degeneration. For neovascular (wet) age-related macular degeneration (AMD), the usual dosage ...
More Common. Back pain. Less common. Acid or sour stomach; belching; burning, crawling, itching, numbness, prickling, pins and ... Detailed ReoPro dosage information Precautions While Using This Medicine. Tell all of your medical doctors and dentists that ... Less common. Black, tarry stools; bleeding gums; blood in urine or stools; pinpoint red spots on skin; unusual bleeding or ... For injection dosage form: *For prevention of blood clots during percutaneous coronary intervention (the procedure to open ...
Apple cider vinegar has been used as a home remedy for many common health conditions. What about ED? Heres what we know. ... All possible dosages may not be included here. Your doctor will tell you what dosage is right for you. Your dosage, drug form, ... Typical starting dosage: 10 mg.. *Dosage increases: Your doctor may increase your dose to 20 mg or decrease it to 5 mg. This ... Typical starting dosage: 2.5 mg per day.. *Dosage increases: Your doctor may increase your dose to 5 mg per day, depending on ...
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Common Brand Names: Adrenaclick, Adrenalin, Adrenalin Chloride, Auvi-Q, Epipen, Epipen Jr, Symjepi, Twinject ... Dosage: How Much EpiPen Should I Take? Drug Content Provided and Reviewed by IBM Micromedex® ... For injection dosage form (solution): * For allergic reactions: * Adrenaclick®, Auvi-q®, Epipen®, Epipen Jr®, Twinject®: * ... Your dosage will vary depending on your medical condition, weight, and response to treatment in different individuals. ...
Common Side Effects The following are some of the more common side effects of using Annovera. If you notice these side effects ... Dosage: How Much Annovera Should I Take? Drug Content Provided and Reviewed by IBM Micromedex® ... For vaginal dosage form (vaginal system): * For contraception (to prevent pregnancy): * Adults-One vaginal system inserted into ... The most common side effects of hormonal birth control like Annovera include headache, nausea or vomiting, yeast infections, ...
Common Drug Related Problems. *Inappropriate drug choice. *Inappropriate dosage. *Adverse drug reactions ...
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Dosage *. Two-dose series, spaced 2-6 months apart. *. 0.5 mL/dose ... Both local and systemic reactions to Shingrix are quite common. The clinical trials of Shingrix and reports to the Vaccine ... Before you administer Shingrix, CDC recommends counseling your patients about the common reactions to the vaccine. You should ... Cite this: Shingrix Update: Common Shingrix Reactions--Which Can Be Prevented? - Medscape - Feb 01, 2019. ...
Creative Commons Attribution-Non Commercial Licence. The IPKat licenses the use of its blog posts under this Creative Commons ... Dosage regime patent revoked in a Salesian judgment Darren Smyth Thursday, May 22, 2014 - invalidity, levonorgestrel, ... Dosage regime patent revoked in a Salesian judgment Reviewed by Darren Smyth on Thursday, May 22, 2014 Rating: 5 ... The IPKat licenses the use of its blog posts under a Creative Commons Attribution-Non Commercial Licence. Print this post Share ...
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  • I recommend that parents review the correct dosage at every well-baby checkup, depending on the current weight of baby," says Wendy Sue Swanson , MD, a Wisconsin-based pediatrician. (thebump.com)
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  • It is more effective at a lower dosage which means it is less likely to build tolerance or addiction compared to the rest of the strains. (linacre.org)
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  • Prescription errors are one of the most common types of medical malpractice. (champaignpersonalinjurylawyer.com)
  • The medicine is not required to have the prescription of a doctor, but you must consult with a urologist regarding the dosage you need in case of dosage that is too high could be hazardous. (mytoppills.com)
  • It will compare each prescription with GBDT modeling results, determine whether the glucocorticoids prescription (including type, dosage, and course of treatment) is reasonable to be used in the consultation service, and will provide a real-time automatic warning alert for unreasonable glucocorticoids prescription. (who.int)
  • Use our helpful dosage chart to find out how to give Infant Tylenol safely. (thebump.com)
  • You'll notice on the bottle of Infant Tylenol that it doesn't give dosages for children under 2 years old, but instead says to call your doctor. (thebump.com)
  • As long as you talk to your doctor first to get the correct Infant Tylenol dosage, there's actually no age that's considered too young to administer the medicine-in fact, Infant Tylenol is sometimes even given to preemies. (thebump.com)
  • Baby's pediatrician will be able to recommend whether or not to give the medicine to baby and what the correct Infant Tylenol dosage should be based on your child's weight. (thebump.com)
  • Evidence of weight gain for underweight women is twice as common in infants. (berea.edu)
  • This process is influenced by several factors (eg, insulin dosage, injection route and site), which is why considerable intra- and interpatient variability is seen. (mims.com)
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  • The term dosage form can also sometimes refer only to the pharmaceutical formulation of a drug product's constituent drug substance(s) and any blends involved, without considering matters beyond that (like how it is ultimately configured as a consumable product such as a capsule, patch, etc. (wikipedia.org)
  • The pharmaceutical solid dosage contract manufacturing market is predicted to garner handsome revenue over the forecast period from 2020 to 2030. (transparencymarketresearch.com)
  • The growth of the pharmaceutical solid dosage contract manufacturing market is primarily attributed to pharmaceutical solid dosage contract manufacturing being the largest segment among all types of pharmaceutical formulation outsourcing. (transparencymarketresearch.com)
  • Key parameters based on which the pharmaceutical solid dosage contract manufacturing market is divided are product type and drug release pattern. (transparencymarketresearch.com)
  • The report on pharmaceutical solid dosage contract manufacturing market is an all-important tool that covers growth trends, demand dynamics, and opportunities in the said market over the 2020 -2030 forecast period. (transparencymarketresearch.com)
  • Further, the report looks into regional landscape of the pharmaceutical solid dosage contract manufacturing market, including revenue analysis of each of them for the 2020-2030 forecast period. (transparencymarketresearch.com)
  • Insights into the competitive landscape, which covers revenue share and growth strategies of key players in the pharmaceutical solid dosage contract manufacturing market is presented in this report. (transparencymarketresearch.com)
  • The pharmaceutical solid dosage contract manufacturing market is a choc-a-bloc of companies of varying sizes. (transparencymarketresearch.com)
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  • Increase in budget for clinical trials and partnership with small-size companies are some other growth strategies of top-notch players in the pharmaceutical solid dosage contract manufacturing market. (transparencymarketresearch.com)
  • Key factors fuelling the pharmaceutical solid dosage contract manufacturing market include more flexible manufacturing, streamlined development, reduced net costs, and availability of higher quality product. (transparencymarketresearch.com)
  • Some other benefits of pharmaceutical solid dosage contract manufacturing are improved efficiency, minimal cost of drug formulation, better access of experts, allows pharma companies to focus on core competencies, minimal interruptions in business continuity, and mitigation of risks with the advice of experts. (transparencymarketresearch.com)
  • On the downside, lack of skilled technical staff at contract manufacturing organizations (CMOs) and low production capacity are some factors slowing hampering the growth of pharmaceutical solid dosage contract manufacturing market. (transparencymarketresearch.com)
  • Geographically, the pharmaceutical solid dosage contract manufacturing market is divided into North America, Western Europe, Eastern Europe, Asia Pacific, Latin America, and the Middle East and Africa. (transparencymarketresearch.com)
  • Among them, North America and Europe are frontrunners in the pharmaceutical solid dosage contract manufacturing market. (transparencymarketresearch.com)
  • Factors such as high cost of R&D of pharmaceutical formulations and substantial budgets of pharmaceutical companies cement growth of the pharmaceutical solid dosage contract manufacturing market in these regions. (transparencymarketresearch.com)
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  • Such cases include wrong medication dosage, misdiagnosis, or childbirth injuries. (axcessnews.com)
  • The route of administration (ROA) for drug delivery is dependent on the dosage form of the substance in question. (wikipedia.org)
  • In addition, the most common form of these products on the market is capsules. (vanillamist.com)
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