The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
An alkylating agent of value against both hematologic malignancies and solid tumors.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Tumors or cancer of the LUNG.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A malignant epithelial tumor with a glandular organization.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.
Tumors or cancer of the human BREAST.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A group of diterpenoid CYCLODECANES named for the taxanes that were discovered in the TAXUS tree. The action on MICROTUBULES has made some of them useful as ANTINEOPLASTIC AGENTS.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Initial drug treatment designed to bring about REMISSION INDUCTION. It is typically a short-term and high-dose drug treatment that is followed by CONSOLIDATION CHEMOTHERAPY and then MAINTENANCE CHEMOTHERAPY.
Comprehensive, methodical analysis of complex biological systems by monitoring responses to perturbations of biological processes. Large scale, computerized collection and analysis of the data are used to develop and test models of biological systems.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.

Adenoviral gene transfer into the normal and injured spinal cord: enhanced transgene stability by combined administration of temperature-sensitive virus and transient immune blockade. (1/14907)

This study characterized gene transfer into both normal and injured adult rat dorsal spinal cord using first (E1-/E3-) or second (E1-/E2A125/E3-, temperature-sensitive; ts) generation of replication-defective adenoviral (Ad) vectors. A novel immunosuppressive regimen aimed at blocking CD4/CD45 lymphocytic receptors was tested for improving transgene persistence. In addition, the effect of gene transfer on nociception was also evaluated. Seven days after treatment, numerous LacZ-positive cells were observed after transfection with either viral vector. By 21 days after transfection, beta-galactosidase staining was reduced and suggestive of ongoing cytopathology in both Ad-treated groups, despite the fact that the immunogenicity of LacZ/Adts appeared less when compared with that elicited by the LacZ/Ad vector. In contrast, immunosuppressed animals showed a significant (P < or = 0.05) increase in the number of LacZ-positive cells not displaying cytopathology. In these animals, a concomitant reduction in numbers of macrophages/microglia and CD4 and CD8 lymphocytes was observed. Only animals that received LacZ/Adts and immunosuppression showed transgene expression after 60 days. Similar results were observed in animals in which the L4-L5 dorsal roots were lesioned before transfection. Gene transfer into the dorsal spinal cord did not affect nociception, independent of the adenovirus vector. These results indicate that immune blockade of the CD4/CD45 lymphocytic receptors enhanced transgene stability in adult animals with normal or injured spinal cords and that persistent transgene expression in the spinal cord does not interfere with normal neural function.  (+info)

Systemic administration of rIL-12 synergistically enhances the therapeutic effect of a TNF gene-transduced cancer vaccine. (2/14907)

Interleukin-12 (IL-12) is a potent antitumor cytokine, which induces and enhances the activity of natural killer (NK) cells, lymphokine activated killer (LAK) cells and cytotoxic T lymphocytes (CTL). IL-12 also stimulates IFN-gamma production from both T cells and NK cells. In this study, we transfected methylcholanthrene-induced fibrosarcoma (MCA-D) with TNF gene and investigated the therapeutic effect of TNF gene-transduced cancer vaccine and whether the vaccination effect is enhanced by systemic administration of recombinant IL-12 (rIL-12), in a murine model. TNF gene-transduced cancer vaccine or systemic administration of rIL-12 showed slight or moderate inhibition of pre-established tumor. However, simultaneous application of the vaccine and rIL-12 resulted in complete eradication. The cytotoxicity of CTL against parental tumor cells was enhanced with the combination of the vaccine and rIL-12, and IFN-gamma production from spleen cells also increased synergistically. Our findings show that synergistic enhancement of CTL activity and IFN-gamma production could play an important role in the antitumor effect of combination therapy using TNF gene-transduced cancer vaccine and rIL-12.  (+info)

Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation. (3/14907)

Both experimental and clinical research have shown that hyperthermia (HT) gives valuable additional effects when applied in combination with radiotherapy (RT). The purpose of this study was evaluation of results in patients with recurrent breast cancer, treated at the Daniel den Hoed Cancer Center (DHCC) with reirradiation (re-RT; eight fractions of 4 Gy twice weekly) combined with HT. All 134 patients for whom such treatment was planned were included in the analysis. The complete response rate in 119 patients with macroscopic tumour was 71%. Including the 15 patients with microscopic disease, the local control rate was 73%. The median duration of local control was 32 months, and toxicity was acceptable. The complete response (CR) rate was higher, and the toxicity was less with the later developed 433-MHz HT technique compared with the 2450-MHz technique used initially. With this relatively well-tolerated treatment, palliation by local tumour control of a worthwhile duration is achieved in the majority of patients. The technique used for hyperthermia appeared to influence the achieved results. The value of HT in addition to this re-RT schedule has been confirmed by a prospective randomized trial in a similar patient group. In The Netherlands, this combined treatment is offered as standard to patients with breast cancer recurring in previously irradiated areas.  (+info)

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (4/14907)

The use of megestrol acetate in the treatment of weight loss in gastrointestinal cancer patients has been disappointing. The aim of the present study was to compare the combination of megestrol acetate and placebo with megestrol acetate and ibuprofen in the treatment of weight loss in such patients. At baseline, 4-6 weeks and 12 weeks, patients underwent measurements of anthropometry, concentrations of albumin and C-reactive protein and assessment of appetite, performance status and quality of life using EuroQol-EQ-5D and EORTC QLQ-C30. Thirty-eight and 35 patients (median weight loss 18%) were randomized to megestrol acetate/placebo or megestrol acetate/ibuprofen, respectively, for 12 weeks. Forty-six (63%) of patients failed to complete the 12-week assessment. Of those evaluable at 12 weeks, there was a decrease in weight (median 2.8 kg) in the megestrol acetate/placebo group compared with an increase (median 2.3 kg) in the megestrol acetate/ibuprofen group (P<0.001). There was also an improvement in the EuroQol-EQ-5D quality of life scores of the latter group (P<0.05). The combination of megestrol acetate/ibuprofen appeared to reverse weight loss and appeared to improve quality of life in patients with advanced gastrointestinal cancer. Further trials of this novel regimen in weight-losing patients with hormone-insensitive cancers are warranted.  (+info)

The minimum CD34 threshold depends on prior chemotherapy in autologous peripheral blood stem cell recipients. (5/14907)

We analysed 57 patients with non-myeloid malignancies who received a non-purged autologous PBSCT. All had similar mobilisation and conditioning regimens. A high prior chemotherapy score and the number of chemotherapy lines used (P = 0.015 and P = 0.01, respectively) were adverse predictors of CD34 cell yields. Lower CD34 values (P = 0.002) were seen in patients treated with potent stem cell toxins (BCNU, melphalan, CCNU and mustine), designated toxicity factor 4 agents (TF4). All patients infused with grafts containing CD34 cell doses between 1.0 and 2.0 x 10(6)/kg (range 1.25-1.90) engrafted by day 51. The only variable associated with slow platelet recovery was exposure to TF4 (P = 0.007). The majority of patients with CD34 >1.0 x 10(6)/kg achieved rapid and sustained engraftment and the only predictive factor of delayed recovery is prior exposure to stem cell toxins. Potential PBSCT candidates should if possible avoid first line and salvage chemotherapy containing TF4 drugs. We therefore advocate a minimum CD34 threshold of >1.0 x 10(6)/kg in patients without extensive prior chemoradiotherapy, and > or = 2.0 x 10(6)/kg in all other patients.  (+info)

Infectious complications in 126 patients treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. (6/14907)

The effect of an extensive prophylactic antimicrobial regimen was prospectively assessed in 126 patients after high-dose chemotherapy and autologous PBSC. They received ciprofloxacin (500 mg/12 h), acyclovir (200 mg/6 h), and itraconazole (200 mg/12 h) orally until neutrophil recovery. Febrile patients received i.v. imipenem (500 mg/6 h) to which vancomycin and amikacin were added if fever persisted for 2-3 and 5 days, respectively. Amphotericin B lipid complex was further given on day 7 or 8 of fever. Median times for a neutrophil count of >0.5 x 10(9)/l and a platelet count of >20 x 10(9)/l were 9 and 11 days. Severe neutropenia (<0.1 x 10(9)/l) lasted for a median of 5 days in which 72% of febrile episodes and 50% of cases of bacteremia occurred. Gram-positive bacteria were isolated in 30 of 40 episodes of bacteremia, 25 of which were caused by Staphylococcus epidermidis. Clinical foci were the intravascular catheter in 35 cases, respiratory infection in 11, cellulitis in two, anal abscess in one, and neutropenic enterocolitis in one. The high incidence of febrile episodes (94%) and bacteremias (31%) may be due to the lack of efficacy of antimicrobial prophylaxis and the persistence of a 5-day period of severe neutropenia.  (+info)

Lymphomatoid granulomatosis following autologous stem cell transplantation. (7/14907)

Lymphomatoid granulomatosis (LYG) is a rare angio-destructive lymphoproliferative disorder (LPD) of uncertain etiology, with prominent pulmonary involvement. Recent studies indicate that LYG is an Epstein-Barr virus (EBV)-associated B cell LPD with large numbers of background reactive T lymphocytes (T cell-rich B cell lymphoma). Although the disease frequently, but not exclusively, occurs in various immunodeficiency states, it has not been reported in association with the transient immunosuppression following autologous bone marrow/peripheral stem cell transplantation (ABM/PSCT). We describe a patient who developed lymphomatoid granulomatosis of the lung approximately 2 weeks after high-dose chemotherapy and autologous peripheral stem cell transplantation for multiple myeloma. Although molecular studies showed no evidence of EBV genome in the biopsy material, the serologic profile with high IgM titers was suggestive of primary EBV infection. Complete radiologic remission occurred following reconstitution of the patient's immune response after a 2-week course of ganciclovir treatment. Despite the apparently low frequency of LPD (both LYG and EBV-associated post-transplant lymphoma) in the ABMT setting, we believe that it should be considered in the differential diagnosis of patients whose clinical course following ABMT is complicated by fevers, in the absence of an identifiable infectious process.  (+info)

Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer. (8/14907)

5-Fluorouracil (5-FU) is an effective enhancer of radiation therapy (RT) in head and neck cancers. Due to rapid, predominantly hepatic metabolism by dihydropyrimidine dehydrogenase (DPD) and suggested clinical benefit from prolonged drug exposure, 5-FU is commonly given by continuous infusion. Eniluracil is a novel DPD-inactivator designed to prolong the half-life of 5-FU and provide sustained plasma concentrations of 5-FU with oral dosing. We conducted a Phase I study of the safety and efficacy of eniluracil given with oral 5-FU in patients receiving concurrent RT for recurrent or advanced squamous cell carcinomas of the head and neck. Thirteen patients with recurrent, metastatic, or high-risk (defined as an expected 2-year survival rate of <10%) head and neck cancer were enrolled and treated with concomitant chemoradiotherapy on an every-other-week schedule. Eniluracil at a fixed dose [20 mg twice a day (BID)] was given for 7 consecutive days (days 1-7). 5-FU and RT were given on 5 consecutive days (days 2-6). One patient was treated with once-daily RT (2.0 Gy fractions). The remaining patients received hyperfractionated RT (1.5-Gy fractions BID). The initial dose of 5-FU was 2.5 mg/m2 given BID. Dose escalation in patient cohorts was scheduled at 2.5-mg/m2 increments, with intrapatient dose escalation permitted. Lymphocyte DPD activity and serum 5-FU and uracil concentrations were monitored during two cycles. DPD activity was completely or nearly completely inactivated in all patients. Sustained, presumed therapeutic concentrations of 5-FU were observed at a dose of 5.0 mg/m2 given BID. Cumulative dose-limiting myelosuppression (both neutropenia and thrombocytopenia) was observed during the fourth and fifth cycles following administration of 5.0 mg/m2 5-FU BID. One patient died of neutropenic sepsis during cycle 4. Other late cycle toxicities included diarrhea, fatigue, and mucositis. Grade 3 mucositis was observed in 4 patients, but no grade 4 mucositis or grade 3 or 4 dermatitis was observed. A second patient death occurred during cycle 1 of treatment. No specific cause of death was identified. The study was subsequently discontinued. Cumulative myelosupression was the significant dose-limiting toxicity of oral 5-FU given with the DPD-inactivator eniluracil on an every-other-week schedule. Clinical radiation sensitization was not observed, based on the absence of dose-limiting mucositis and dermatitis. Alternative dosing schedules need to be examined to determine the most appropriate use of eniluracil and 5-FU as radiation enhancers.  (+info)

Patients with locally advanced esophageal cancer who are treated with trimodality therapy have a high recurrence rate. Preclinical evidence suggests that inhibition of cyclooxygenase 2 (COX2) increases the effectiveness of chemoradiation, and observational studies in humans suggest that COX-2 inhibition may reduce esophageal cancer risk. This trial tested the safety and efficacy of combining a COX2 inhibitor, celecoxib, with neoadjuvant irinotecan/cisplatin chemoradiation. This single arm phase 2 trial combined irinotecan, cisplatin, and celecoxib with concurrent radiation therapy. Patients with stage IIA-IVA esophageal cancer received weekly cisplatin 30 mg/m2 plus irinotecan 65 mg/m2 on weeks 1, 2, 4, and 5 concurrently with 5040 cGy of radiation therapy. Celecoxib 400 mg was taken orally twice daily during chemoradiation, up to 1 week before surgery, and for 6 months following surgery. Forty patients were enrolled with stage IIa (30 %), stage IIb (20 %), stage III (22.5 %), and stage IVA (27.5 %)
The abscopal effect is mediated by a systemic anti-tumor immune response and reflects the regression of non-irradiated metastatic lesions at a distance from the primary site of irradiation. This review will focus on understanding the biological rationale behind the abscopal effect of radiotherapy (RT), which has a recently renewed interest as a result of the successes achieved with immunotherapy and RT in combination. Both RT and immunotherapy are standard components of modern treatment regimens. Combination of these two modalities results in an increased response in the irradiated lesions themselves and the metastatic regions distant from the site of irradiation. We will summarize the abscopal effect of radiotherapy, in particular, the synergistic effect of RT and immunotherapy.
Fingerprint Dive into the research topics of Long-term follow-up of the RTOG 9501/intergroup phase III trial: Postoperative concurrent radiation therapy and chemotherapy in high-risk squamous cell carcinoma of the head and neck. Together they form a unique fingerprint. ...
Based on positive results from the Radiation Therapy Oncology Group (RTOG) 85-01 trial, the conventional nonsurgical treatment of esophageal carcinoma is combined-modality therapy. Dose intensification of the RTOG 85-01 regimen, examined in the Intergroup (INT)-0123/RTOG 94-05 trial, did not improve local control or survival. Areas of clinical investigation include the development of combined-modality therapy regimens with newer systemic agents, the use of 18F-fluorodeoxyglucose positron-emission tomography to assist in the development of innovative radiation treatment planning techniques, and the identification of prognostic molecular markers. The addition of surgery following primary combined-modality therapy apparently does not improve survival, but this finding is controversial.
The analysis was based on a total of 468 patients with a median age of 66 years; 64% were younger than age 70, 19% were aged 70 to 75, and 17% were older than age 75. Among all patients, 82% were male. Approximately 94% had transitional cell carcinoma; 61% had clinical stage T2 tumors, and 35% had clinical stage T3. Median follow-up was 4.3 years for all patients and 7.8 years among 205 survivors.. Seventy-two percent of patients had a complete response to combined-modality therapy. The 5- and 10-year estimated overall survival rates were 57% and 36%, respectively; 5- and 10-year estimated disease-specific survival rates were 71% and 65%.. The majority of local failures in the bladder were non-muscle invasive, with an estimated 5- and 10-year incidence of 31% and 36%. The 5- and 10-year estimates for muscle-invasive failure rates were 13% and 14%, and 5- and 10-year estimates of distant metastases were 31% and 35%.. This recurrence pattern underscores the need for careful post-treatment ...
In this study, we show in breast and colon carcinoma models that fractionated local radiotherapy to one palpable tumor can synergize with CTLA-4 blockade to induce antitumor T-cell immunity and inhibit a second palpable tumor outside the radiation field. This abscopal effect was not seen with radiotherapy alone. Although localized tumor irradiation by itself has been shown to enhance the generation of tumor-specific T cells in both preclinical models and patients, the therapeutic effects of this response remain undetermined (3, 19). Clearly, irradiation to the primary tumor was required in our models to induce growth inhibition of the secondary tumors outside the field because CTLA-4 blockade by itself was ineffective (Figs. 2 and 6). This is consistent with the hypothesis that radiation-induced immunogenic tumor cell death as well as its induction of danger signals contribute to generate an in situ vaccine (20-22). Whereas the response generated is not sufficient to be therapeutically ...
The addition of chemo-radiotherapy following surgery to remove pancreatic cancer tumours has been shown to reduce the risk of the cancer returning researchers in the USA have found.. The use of adjuvant radiotherapy has been a controversial topic over the years with many studies reporting conflicting evidence about whether or not the use of chemo- radiotherapy is beneficial.. The researchers from the Mayo Clinic in the USA, reporting in the International Journal of Radiation Oncology, Biology and Physics ((ASTRO)) studied 458 patients who had received pancreatic cancer surgery between March 1987 and January 2011. Out of those, 378 had received chemotherapy + chemo-radiotherapy after surgery and 80 had received only chemotherapy.. The chemotherapy in this study typically consisted of six cycles of gemcitabine and the chemo-radiotherapy consisted of 50.4Gy in 28 fractions concurrent with 5-fluorouracil. Of those who had received chemotherapy + chemo-radiotherapy following their surgery, 80 per ...
Results of radiation given to patients with AIDS-related high-grade CNS lymphoma have been disappointing, with short survival times due to infection complications. However, complete response has been documented after radiation in some patients. High-dose MTX will be used to improve the possibility of a greater antineoplastic response than that obtained by radiation alone. Since the underlying immunodeficiency state is not affected by therapy directed against the lymphoma, patients are still prone to life-threatening opportunistic infections or relapse of lymphomatous disease within the CNS. Accordingly, AZT will also be used in an attempt to alter the overall natural history of the disease.. Radiation begins on day 1 of therapy. Patients receive dexamethasone orally (PO) or by intravenous injection (IV) on days 1-10. MTX IV over 6 hours weekly for a total of 4 doses starts 1 week after completion of the cranial radiation. Leucovorin (LCV) IV or PO begins 6 hours after MTX has been completed over ...
Results of radiation given to patients with AIDS-related high-grade CNS lymphoma have been disappointing, with short survival times due to infection complications. However, complete response has been documented after radiation in some patients. High-dose MTX will be used to improve the possibility of a greater antineoplastic response than that obtained by radiation alone. Since the underlying immunodeficiency state is not affected by therapy directed against the lymphoma, patients are still prone to life-threatening opportunistic infections or relapse of lymphomatous disease within the CNS. Accordingly, AZT will also be used in an attempt to alter the overall natural history of the disease.. Radiation begins on day 1 of therapy. Patients receive dexamethasone orally (PO) or by intravenous injection (IV) on days 1-10. MTX IV over 6 hours weekly for a total of 4 doses starts 1 week after completion of the cranial radiation. Leucovorin (LCV) IV or PO begins 6 hours after MTX has been completed over ...
The abscopal effect can sometimes increase survival with cancer. Learn about what cancers and treatments may have this response, and why it occurs.
Generating and grading the abscopal effect: proposal for comprehensive evaluation of combination immunoradiotherapy in mouse models
Generating and grading the abscopal effect: proposal for comprehensive evaluation of combination immunoradiotherapy in mouse models
The standard of care for women with stage III/IVA endometrial cancer following surgery has been chemotherapy and radiation to prevent recurrence. But in a surprising new finding, radiation combined with chemotherapy did not ...
Two hundred and eighty-eight patients were treated for newly diagnosed colorectal or anal cancer at William Beaumont Hospital from 2008 to 2009. Within this population, forty patients were referred to the clinic preoperatively and forty-eight patients were referred postoperatively. Two hundred patients were never treated in the clinic at all during the study period. In terms of preoperative evaluation, clinic patients underwent significantly more NCCN-compliant testing than patients managed outside the clinic-abdomen CT (97.5% vs. 83.1%, p=0.03), chest CT (95% vs. 37.1%, p,0.0001), CEA testing (100% vs. 63.8%, p,0.0001), and TRUS for rectal cancer (88% vs. 37.7%, p,0.0001). In addition, a complete preoperative work-up was performed in the clinic group over three times more frequently for colon cases and over five times more frequently for rectal cancers when compared to the non-clinic group. Access to multimodal therapy was also significantly enhanced in patients referred to the clinic as ...
Combined-modality approaches for the treatment of non-small-cell lung cancer (NSCLC), head and neck cancer, and esophageal cancer offer survival benefits by improving locoregional control and treating micrometastatic disease. The taxanes are active, tolerable drugs in these solid tumors and have radiation-sensitizing activity. 1
Health,...Study confirms effectiveness of widely used approach experts say ...MONDAY Dec. 15 (HealthDay News) -- Men with locally advanced prostate...The addition of radiotherapy kept patients healthy much longer the Sw... The study will change practice in the treatment of locally advanced o...,Radiation,Plus,Hormone,Therapy,Cuts,Prostate,Cancer,Deaths,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
ABSTRACT: The multimodal therapy of ADHD with comorbidities proved its efficacy în comparison with the unimodal therapies. We will present the preliminary results of the first nine months of multimodal therapy, which has been applied on a number of 18 children and adolescents with ages between 8 and 17 years. ...
Truong MT, Zhang Q, Rosenthal DI, List M, Axelrod R, Sherman E, Weber R, Nguyen-Tân PF, El-Naggar A, Konski A, Galvin J, Schwartz D, Trotti A, Silverman C, Singh A, Godette K, Bonner JA, Jones CU, Garden AS, Shenouda G, Matthiesen C, Le QT, Bruner D: Quality of Life and Performance Status From a Substudy Conducted Within a Prospective Phase 3 Randomized Trial of Concurrent Accelerated Radiation Plus Cisplatin With or Without Cetuximab for Locally Advanced Head and Neck Carcinoma: NRG Oncology Radiation Therapy Oncology Group 0522. Int J Radiat Oncol Biol Phys 97(4): 687-699, March 2017 ...
More than 400 respected luminaries explore todays most effective strategies for managing every type of cancer by stage of presentation - discussing the role of all appropriate therapeutic modalities as well as combined-modality treatments. This multidisciplinary approach will help your cancer team collaboratively face the toughest clinical challenges and provide the best possible care for every cancer patient.
As a first step toward developing quantitative models, investigators recently developed a mathematical framework to simulate the systemic dissemination of T cells activated in response to focal therapy.
Radiotherapy (RT), the major anti-cancer modality for more than half of cancer patients after diagnosis, has the advantage of local tumor control with relatively less systematic side effects comparing to chemotherapy. However, the efficacy of RT is limited by acquired tumor resistance leading to the risks of relapse and metastasis. To further enhance the efficacy of RT, with the renaissances of targeted immunotherapy (TIT), increasing interests are raised on RT combined with TIT including cancer vaccines, T-cell therapy, and antibody-based immune checkpoint blockers (ICB) such as anti-CTLA-4 and anti-PD1/PD-L1. In achieving a significant synergy between RT and TIT, the dynamics of radiation-induced response in tumor cells and stromal cells, especially the cross-talk between tumor cells and immune cells in the irradiated tumor microenvironment (ITME) as highlighted in recent literature are to be elucidated. The abscopal effect refereeing the RT-induced priming function outside of ITME could be ...
Primary Endpoint: To determine the maximum tolerated dose (MTD) of vorinostat + radiation therapy (RT) in patients with locally advanced pancreat
Improved dose tracking and a more multimodal approach are just a few of the ways treatment planning systems are delivering higher-quality radiation therapy
Recent results of a phase II/III in locally advanced Soft Tissue Sarcoma patients demonstrated clinical benefits of intratumorally injected HfO2-NP activated by radiotherapy compared to radiotherapy alone, validating their first-in-class mode of action. In addition, animal studies have reported that HfO2-NP+RT can induce an abscopal effect, where RT alone cannot. Here, using a mouse abscopal assay, we measured T cells infiltrates in treated and untreated tumors after HfO2-NP intratumor injection and activation with RT, and their role in the abscopal effect.. These data indicate that the immunogenic conversion of the tumor microenvironment triggered by HfO2-NP+RT generates the abscopal effect by activation of CD8+ T cells. HfO2-NP+RT may potentiate a pro-inflammatory microenvironment appropriate for enabling an anti-tumor immune response. It may act as effective in-situ cancer vaccine and be combined with immunotherapeutic agents across oncology.. ...
Loco-regional recurrences after intial surgery in patients with esophageal cancer remain a serious challenge to clinical oncologists. The NCCN Guidelines pointed out that a highly selected group of patients with local-regional tumor recurrence after initial surgery may be considered fit and able to tolerate concurrent radio-chemotherapy with a potential for cure [18]. In a line with the previous studies, our data indicated that salvage concurrent radio-chemotherapy was an active and promising treatment strategy for such patients, reaching a median OS of 13.3 months with tolerable side-effects.. The present protocol of concurrent radio-chemotherapy was completed in 74% (37/50) of the patients, and no serious treatment related toxicities were observed. The tumor response rate was nearly 72% in R-TP and R-FP group respectively, with a 3-year survival rate of 14%. These results are very similar to those reported in previous studies [13, 15]. Yamashita et al.[13] reported the results of radiotherapy ...
TY - JOUR. T1 - Adjuvant therapy in colorectal cancer. A randomized trial comparing radio-chemotherapy and radio-chemotherapy combined with methanol extraction residue of BCG, MER. AU - Robinson, E.. AU - Bartal, A.. AU - Cohen, Y.. AU - Milstein, D.. AU - Mekori, T.. PY - 1979/12/1. Y1 - 1979/12/1. N2 - Fifty-three patients with colorectal cancer (Dukes B 2 and C) were randomized after surgery. One group was treated by radio-and/or chemotherapy and the second by radio-and/or chemotherapy and MER. After 24 and 36 months a significant longer disease free interval, lower recurrence rate and better survival was found in the group treated by radio-chemo-and immunotherapy. Treatment was well tolerated and there were few local side effects from the MER injections. The long time efficacy of this adjuvant treatment whether it increases the cure rate or only delays recurrence requires longer follow-up.. AB - Fifty-three patients with colorectal cancer (Dukes B 2 and C) were randomized after surgery. ...
The aim of this retrospective study was to compare concurrent radiation therapy (RT) combined with peroral chemotherapy (UFT or TS-1) with conventional RT for T2N0 glottic cancer. Between 1974 and 2005, 153 patients with T2N0 glottic cancer were treated with radiation alone or radiation combined with peroral (UFT or TS-1) or intravenous chemotherapy. All except one patient were treated with 2 Gy per fraction, 5 fractions per week, totaling 60 Gy; and the remaining patient was treated with 1.8 Gy per fraction, 5 fractions per week, totaling 61.2 Gy. Eighty-three patients were concurrently given UFT, 24 were given TS-1, 23 intravenous chemotherapy (mainly cisplatin; the Pt Group), and 23 had no chemotherapy. The 5-year local control rate was 83.4%. Stratified by RT alone (the RT group) and concurrent chemoradiation therapy (the CCRT group), 5-year local control rates of the RT and CCRT groups were 82.7% and 83.4%, respectively (p=NS). Stratified by chemotherapy regimens of the CCRT group, 3-year ...
For all 250 patients, the overall median survival was 27 months, the cause-specific survival was 27 months, the local progression-free survival was 32 months, and distant metastasis-free survival was not achieved; and the respective 5-year survival rates were 27%, 32%, 45%, and 68%. CF achieved significantly inferior survival than either HFX RT alone or HFX RT-Pac/C (P = .0332 and P = .0013, respectively), and no difference was observed between the 2 HFX RT regimens (P = .1934). Only acute hematologic high-grade toxicity (grade ≥3) was more frequent with HFX RT-Pac/C than with either RT alone, whereas other toxicities were similar between the 3 treatment groups. ...
Rare Cancer News & Clinical Trials » Trial - Sarcoma » A Study of Olaparib With Concomitant Radiotherapy in Locally Advanced/Unresectable Soft-tissue ...
article{4430146, abstract = {Purpose: Combined-modality treatment is standard treatment for patients with clinical stage I/II Hodgkin lymphoma (HL). We hypothesized that an early positron emission tomography (PET) scan could be used to adapt treatment. Therefore, we started the randomized EORTC/LYSA/FIL Intergroup H10 trial evaluating whether involved-node radiotherapy (IN-RT) could be omitted without compromising progression-free survival in patients attaining a negative early PET scan after two cycles of ABVD (doxorubicin, bleomycin, vinblastine, and dacarbazine) as compared with standard combined-modality treatment. Patients and Methods: Patients age 15 to 70 years with untreated clinical stage I/II HL were eligible. Here we report the clinical outcome of the preplanned interim futility analysis scheduled to occur after documentation of 34 events in the early PET-negative group. Because testing for futility in this noninferiority trial corresponds to testing the hypothesis of no difference, a ...
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
Results Out of the 12 patients in the study, 6 did not receive radiotherapy either because they elected for subsequent radical surgery (3 patients) or were unfit for further treatment and underwent close follow-up (3 patients).. In the radiotherapy group, 2 patients had pre-op Long-Course Chemo-radiotherapy (LCCRT) with a good partial response, 2 were included in the national TEM and Radiotherapy in Early Rectal cancer (TREC) trial and had pre-op Short Course radiotherapy (SCRT) and 2 had adjuvant LCCRT + Papillon contact radiotherapy following TEM.. Median follow-up was 20 months. Patients not undergoing radial surgery had 3 monthly MR and sigmoidoscopy for 1 year and 6 monthly MR and sigmoidoscopy for a further 2 years.. In the no-radiotherapy group, 1 of the 3 patients who underwent subsequent radical surgery had involved mesorectal lymph nodes and 1 of those undergoing close follow-up without radical surgery developed mesorectal nodal recurrence. In radiotherapy group 1 patient, in the TREC ...
Jonathan D. Schoenfeld, MD, MPhil, MPH, director, melanoma radiation oncology, physician, assistant professor of radiation oncology, Harvard Medical School, Dana-Farber Cancer Institute, discusses potential combination regimens of low-dose radiation therapy and immunotherapy to treat patients with head and neck cancer.
Selected high-risk patients with head and neck squamous cell carcinoma receive postoperative radiation therapy (RT), with or without concurrent chemotherapy, following primary surgical resection with the aim of improving locoregional control and surv
PubMed journal article [Combined-modality therapy for 150 cases of early-stage Hodgkins lymphoma were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Positron emission tomography using fluoro-deoxy-glucose has demonstrated added value in the clinical management of patients with colorectal cancer [6]. This includes primary staging, detection of recurrence, prediction of individual prognosis, therapy response, and evaluation of treatment response as assessed in this investigation [8].. The interest in FDG-PET to assess tumour response to CRT began in the early 1990 s. Rectal cancer is a disease model of particular interest, not only for its high incidence, but also because an accurate and non-invasive method to evaluate response to preoperative CRT could lead to patients selection for minimally invasive surgical approaches or even selection of candidates for additional chemotherapy and observation without any kind of surgery [2, 3].. Experts at the Memorial Sloan-Kettering Cancer Center reported a pioneer prospective assessment of LARC response to preoperative CRT using FDG-PET in 2000 [9]. Today, literature is mixed in regard to the ability ...
Clinical trial for Gynecological Infections , GOG 0238: A Randomized Trial of Pelvic Irradiation with or without Concurrent Weekly Cisplatin in Patients with Pelvic-only Recurrence of Carcinoma of the Uterine Corpus.
A rarely seen phenomenon in cancer patients - in which focused radiation to the site of one tumor is associated with the disappearance of metastatic tumors all over the body - has been reported in a patient with melanoma treated with the immunotherapeutic agent ipilimumab (Yervoy™).
The survival of children with non-Hodgkins lymphoma (NHL) has improved in the recent past through the systematic application of intensive therapy employing involved field radiation plus combinations...
Prognosis of patients who present with metastasized rectal cancer is poor. Without treatment, median survival is estimated at six months. Treatment options are available for the primary tumor and the metastatic disease. The primary tumor may be resected or treated with radiation therapy. Resection of the primary tumor is controversial, as it may not improve the quality of life in patients with a poor prognosis due to the metastatic disease. As the majority of patients with primary stage IV rectal cancer present with a locally advanced primary tumor, resection of the primary tumor would necessitate preoperative radiation therapy. Metastatic disease may respond to chemotherapy. In recent years, advances in chemotherapy have increased the response rate to 40 percent. Some patients presenting with liver or lung metastases are candidates for resection of their metastatic disease. Neoadjuvant chemotherapy may increase the fraction of patients with resectable metastatic disease, or may allow for ...
OncoLink, the Webs first cancer resource,provides comprehensive information on coping with cancer, cancer treatments, cancer research advances, continuing medical education, cancer prevention, and clinical trials
Once-daily radiotherapy is not superior to twice-daily treatment for patients with small-cell lung cancer receiving concurrent chemoradiotherapy.
Delayed toxicity in the form of progressive damage after completion of treatment is a grave problem. Three patients (RadS6, RadS7, and RadS10) suffered grade 4 delayed toxicity, and all were predicted successfully (Table 1). Toxicity from extrinsic factors cannot be predicted by our approach. Of the five patients with radiation toxicity not predicted by NSC/HAT, at least two (RadS3 and RadS5) were at high risk for toxicity from unconventional treatment protocols. Patient RadS3 suffered grade 3 mucositis in an experimental trial that included high-dose radiation plus tirapazamine, cisplatin, and 5-fluorouracil. Review of patient data after closure of this trial revealed that 28 of 62 (45%) suffered mucositis of grade 3 or higher. Patient RadS5 had an arteriovenous malformation that was treated with stereotactic guidance of a single 18-Gy dose to a 1.8-cm3 volume in the midbrain and pons. After this patient was enrolled for study, Flickinger et al. (23) estimated that stereotactic radiotherapy to ...
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TY - JOUR. T1 - Potential Molecular Targets in the Setting of Chemoradiation for Esophageal Malignancies. AU - Jabbour, Salma K.. AU - Williams, Terence M.. AU - Sayan, Mutlay. AU - Miller, Eric D.. AU - Ajani, Jaffer A.. AU - Chang, Andrew C.. AU - Coleman, Norman. AU - El-Rifai, Wael. AU - Haddock, Michael. AU - Ilson, David. AU - Jamorabo, Daniel. AU - Kunos, Charles. AU - Lin, Steven. AU - Liu, Geoffrey. AU - Prasanna, Pataje G.. AU - Rustgi, Anil K.. AU - Wong, Rosemary. AU - Vikram, Bhadrasain. AU - Ahmed, Mansoor M.. N1 - Publisher Copyright: Published by Oxford University Press 2020.. PY - 2021/6/1. Y1 - 2021/6/1. N2 - Although the development of effective combined chemoradiation regimens for esophageal cancers has resulted in statistically significant survival benefits, the majority of patients treated with curative intent develop locoregional and/or distant relapse. Further improvements in disease control and survival will require the development of individualized therapy based on the ...
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-ener
This phase II trial studies how well lower-dose chemotherapy plus radiation (chemoradiation) therapy works in comparison to standard-dose chemoradiation in treating patients with early-stage anal cancer. Drugs used in chemotherapy, such as mitomycin, fluorouracil, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving chemotherapy with radiation therapy may kill more tumor cells. This study may help doctors find out if lower-dose chemoradiation is as effective and has fewer side effects than standard-dose chemoradiation, which is the usual approach for treatment of this cancer type ...
This phase II trial studies how well lower-dose chemotherapy plus radiation (chemoradiation) therapy works in comparison to standard-dose chemoradiation in treating patients with early-stage anal cancer. Drugs used in chemotherapy, such as mitomycin, fluorouracil, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving chemotherapy with radiation therapy may kill more tumor cells. This study may help doctors find out if lower-dose chemoradiation is as effective and has fewer side effects than standard-dose chemoradiation, which is the usual approach for treatment of this cancer type ...
In lieu of an abstract, here is a brief excerpt of the content: 136 CHAPTER 4 Radiation Therapy and Surgery Radiation therapy, like chemotherapy, is intended to selectively kill malignant cells while sparing normal cells as much as possible. Like chemotherapy, radiation therapy (also called radiotherapy) is most active against rapidly dividing populations of cells. Unlike most forms of chemotherapy, radiation can be applied locally, to specific areas of the body, rather than spreading throughout the entire body via the bloodstream. Radiation therapy may be used alone to treat people with localized lymphocytepredominant Hodgkin lymphoma or localized indolent NHL, but it is more commonly used in combination with chemotherapy (a form of combined modality treatment). Combined modality therapy is most frequently used to treat localized disease, generalized disease in which there is a specific bulky component, or an area of localized disease that remains after chemotherapy treatment. Combined modality ...
What changes are seen among patients with acromegaly after long-term multimodality therapy? Are these patients able to be biochemically controlled?
Cancer is a systemic (throughout the body) disease, no matter what your doctor tells you. Telling patients based on post-operation scans that we got it all is not the truth. Most cancers have been growing and spreading for 5 to 10 years before they are detected and diagnosed. Billions of cancer cells must be present to show up on any scan. Surgery can spread cancer. The word cure in oncology circles has up to fifty different definitions. The only real cure is the one where you live long enough to die from something other than cancer. These survivors are strong, and most utilize a protocol to treat cancer everywhere in their body, rather than relying solely on local surgery, local radiation, and/or chemotherapy. ~ Dr. Bruce West. ...
Diagnostic imaging is a sleuth: It can identify cancer, confirm clinical suspicions and define disease parameters, leading the way to optimum treatment. Wave...
Organ toxicity in cancer therapy is likely caused by an underlying disposition for given pathophysiological mechanisms in the individual patient. Mechanistic data on treatment toxicity at the patient level are scarce; hence, probabilistic and translational linkages among different layers of data information, all the way from cellular targets of the therapeutic exposure to tissues and ultimately the patients organ systems, are required. Throughout all of these layers, untoward treatment effects may be viewed as perturbations that propagate within a hierarchically structured network from one functional level to the next, at each level causing disturbances that reach a critical threshold, which ultimately are manifested as clinical adverse reactions. Advances in bioinformatics permit compilation of information across the various levels of data organization, presumably enabling integrated systems biology-based prediction of treatment safety. In view of the complexity of biological responses to cancer
2 or more types of treatment used alternately or together to get the best results. For example, surgery for cancer is often followed by chemotherapy to kill any cancer cells that may have spread from the original site. See also |b>adjuvant therapy|/b>,|b> neoadjuvant therapy, chemotherapy|/b>.
During high-dose chemotherapy, the patient receives high doses of chemotherapy, and possibly radiation therapy, in order to kill the cancer cells. Whi
Surgery and radiation are often used together in more advanced lesions. As combined treatment has evolved, surgery with postoperative radiation therapy is most often employed. Recent advances in reconstructive surgery have further improved functional and cosmetic outcomes.. In select instances, promising results are being obtained with combined chemotherapy and radiation therapy in an effort to avoid surgical resection.. ...
This unit (1) provides background into understanding how agents that target specific molecules or receptors (molecular‐targeted agents), in particular, agents affecting the tumor vasculature (perivasculature network in tumors), interact with and modify radiation therapy; (2) details factors affecting interpretation of results in murine tumor model experiments utilizing radiation therapy and drug combinations; and (3) provides specific protocols for the application of radiation therapy, both alone and in combination with chemotherapy and/or molecular‐targeted agents
The use of ADT for two months before and two months during RT for early PCa is associated with significantly increased overall survival.
Choose a membership level that meets your changing needs, knowing that each month you get to choose the therapy you want: either our True Transformation Facial or Holistic Wellness Massage that includes the choice of a single modality or multiple modalities customized to your individual needs and concerns.. ...
Dolore perineale worth texas. MEDICINA Archivi - Pagina 2 di 4 - Fisiosaan. Inoltre, verranno discussi nel dettaglio due disturbi pelvi-perineali, la cui minor -La sindrome del cingolo pelvico si caratterizza per un dolore pelvico Hence it would be worth considering them as an adjunct to conservative therapy. College of Science, The University of Texas at Arlington, Arlington, Texas ​ Dolore perineale e pelvico (sintomo per lo più tardivo). La presenza di un Tx: il tumore primitivo non può essere valutato. T0: non cè evidenza di the worth of preoperative multimodality therapy in patients with operable carcinoma of the.. risonanza magnetica multiparametrica della prostata a latina 2017.
We are thrilled to offer a wide range of the most advanced modalities that speed the healing process in conjunction with appropriate manual treatments
Combined Modality Therapy of Central Nervous System Tumors. ISBN 9783540006275. Hoh DJ, Liu CY, Pagnini PG, Yu C, Wang MY, ... Chained lightning: part III--Emerging technology, novel therapeutic strategies, and new energy modalities for radiosurgery. ... technology transfer and the implementation of advanced technologies to the therapy of brain diseases. In 1991, he was appointed ...
"Intracranial choriocarcinoma causing precocious puberty and cured with combined modality therapy". Journal of Paediatrics and ...
December 1983). "Intensive combined modality therapy including low-dose TBI in high-risk Ewing's Sarcoma Patients". Int. J. ... In addition to its use in bone marrow transplantation, total body irradiation has been explored as a treatment modality for ... August 2003). "High-dose therapy for patients with primary multifocal and early relapsed Ewing's tumors: results of two ...
"Manual Lymph Drainage Combined With Compression Therapy for Arm Lymph- edema Following Breast Cancer Treatment" (PDF). Swedish ... Stillerman, Elaine (2009). Modalities for Massage and Bodywork. Mosby. pp. 129-143. ISBN 032305255X. " ... Explanation of Manual lymphedema therapy on the National Cancer Institute web site.. ... they returned to Copenhagen to teach other practitioners to use this therapy. Milady's Guide to Lymph Drainage Massage; Ramona ...
Mira, J.G.: Combined Modality Treatment for Small Cell Lung Cancer. Chapter in Combined Chemotherapy and Radiotherapy in ... He was elected Head of the Radiotherapy department of the Cancer Therapy & Research Center every year between 1993 and 2007. He ... He was named Director of Radiotherapy in the Cancer Therapy & Research Center, under the National Cancer Institute, where he ... McCracken, J.D. and Mira, J.G.: Concurrent Chemotherapy and Radiation Therapy for Limited Small Cell Lung Cancer. Monograph, ...
VST therapy uses active donor T-cells that are isolated from alloreactive T-cells which have proven immunity against one or ... The main members are various types of severe combined immunodeficiency (SCID). T-/B+ SCID (T cells predominantly absent): γc ... Most treatment is therefore passive and palliative, and falls into two modalities: managing infections and boosting the immune ... T-lymphocyte therapies are still in the experimental stage; few are even in clinical trials, none have been FDA approved, and ...
Transgender hormone therapy (male-to-female). *Estradiol-containing birth control pill. *Combined injectable birth control ... there was no difference in survival or cardiovascular toxicity between the two treatment modalities.[21][22] These findings ... It is also used in feminizing hormone therapy for transgender women.[11][19] PEP is a form of high-dose estrogen therapy.[2] ... PEP is used as an intramuscular injection for estrogen therapy of prostate cancer in men.[1][2] It is also used to treat breast ...
It is possible that the two modalities have a synergistic effect and patients may benefit from combined treatment. Prior to the ... An animal tumor model demonstrated improved survival after combined treatment with RFA and radiation therapy compared to either ... Reduced tumor growth with combined radiofrequency ablation and radiation therapy in a rat breast tumor model. Radiology 2005. ... July 2006). "Percutaneous Image-guided Thermal Ablation and Radiation Therapy: Outcomes of Combined Treatment for 41 Patients ...
These therapy modalities are focused on empowering individuals to reduce stress levels and elicit a relaxation response in ... Holistic nursing combines standard nursing interventions with various modalities that are focused on treating the patient in ... Alternative therapies can include stress management, aroma therapy, and therapeutic touch. The combination of interventions ... Several of the therapies included in holistic nursing rely on therapeutic environments to be successful and effective. A ...
... hormone therapy, immunotherapy and combined treatment modalities such as chemo-radiotherapy. Starting in the mid-1990s, the ... is a prostate cancer vaccine Newer forms of chemotherapy Gene therapy Photodynamic therapy Radiation therapy Reoviridae ( ... Reolysin drug therapy) Targeted therapy Natural killer cells can induce immunological memory. Research is being developed to ... Radiation therapy took hold in the 1900s. Chemotherapeutics were developed and refined throughout the 20th century. The U.S. ...
The therapy normally lasts for 5 minutes and is repeated at least 4 times a day. Full treatment programs typically contain a ... The treatment modality of patterning was developed in the 1960s by Glenn Doman and Carl Delacato. The Institutes for the ... range of exercises combined with sensory stimulation, breathing exercises designed to increase oxygen flow to the brain, and ... and treatment primarily focuses on non-invasive physical therapy in each of these stages. In one such stage, the homolateral ...
... quality of combined modality therapy and pathologic response. „J Clin Oncol". 24 (24), s. 3953-3958, Aug 2006. DOI: 10.1200/JCO ... Randomized phase III study comparing irinotecan combined with 5-fluorouracil and folinic acid to cisplatin combined with 5- ... a b c d e f M. Kaminishi, K. Takubo, K. Mafune: The Diversity of Gastric Carcinoma: Pathogenesis, Diagnosis and Therapy. ... Cancer Therapy", 2007. [zarchiwizowane z adresu]. *↑ W.H. Chow, W.J. Blot, T.L. Vaughan, H.A. Risch i inni. Body mass index and ...
The best overall survival rates are seen after combined radiation therapy combined with chemotherapy (5-FU + Mitomycin) in ... This "combined modality" approach has led to the increased preservation of an intact anal sphincter, and therefore improved ... Current gold-standard therapy is chemotherapy and radiation treatment to reduce the necessity of debilitating surgery. ... Standard treatment may include radiation therapy, chemotherapy, and surgery. About 8,300 people are diagnosed a year in the ...
... and combined modality therapy such as radiotherapy with surgery, chemotherapy, or immunotherapy. To provide the treatment ... Radiation can be given as a curative modality, either alone or in combination with surgery and/or chemotherapy. It may also be ... Radiotherapy training in India encompasses the treatment of solid tumors in terms of Chemotherapy, radiation therapy, and ... In Iran, radiation oncologists, who are trained in non-surgical aspects of oncology (including radiation therapy) directly ...
... is therefore often combined with other modalities such as in-person therapy. Important areas of ... Types of therapy available include motor training exercises, speech therapy, virtual reality, robotic therapy, goal setting, ... robotic therapy, and community-therapy. Motor training exercises are the most commonly implemented modality. In motor training ... Robotic therapy has even been combined with virtual reality telerehabilitation to create a virtual environment which responds ...
... combined modality therapies, altered fractionation, cost-effectiveness, and outcomes research. He has run numerous ... Combined modality treatment of tumors of the CNS and thorax, as well as pediatric neoplasms: integrating systemic chemotherapy ... Effects of therapies on cognition and developing methods to improve neurocognitive function. Medical director, the Maryland ... Chair, Brain Tumor Committee, Radiation Therapy Oncology Group. "Faculty Profiles: University of Maryland School of Medicine". ...
Others use a "triple modality" combination of external beam radiation therapy, brachytherapy, and hormonal therapy. In advanced ... when surgery or radiation therapy alone is less likely to cure the cancer. Some radiation oncologists combine external beam ... and photodynamic therapy that permit focal therapy by utilizing image guidance. These therapies are still in beginning or ... and external-beam radiation therapy, proton therapy, high-intensity focused ultrasound (HIFU), cryosurgery, hormonal therapy, ...
... and play therapists combine art therapy methods with basic psychotherapeutic modalities in their treatment. Therapists may ... Art therapy (not to be confused with arts therapy which includes other creative therapies such as drama therapy and music ... Art therapy, as a creative arts therapy modality, originated in the fields of art and psychotherapy and may vary in definition ... Chambala, A (2008). "Anxiety and art therapy: Treatment in the public eye". Art Therapy: Journal of the American Art Therapy ...
This includes the modalities dance therapy, drama therapy, art therapy, music therapy, writing therapy, among others. This may ... meseron therapy and systemic therapies based on the Ubuntu philosophy. Integrative psychotherapy is an attempt to combine ideas ... multimodal therapy, and therapies for specific disorders including PTSD therapies such as cognitive processing therapy and EMDR ... including couples therapy and family therapy. Therapies are sometimes classified according to their duration; a small number of ...
A combined therapeutic approach which is at least twice as effective as other therapeutic modalities published to date is ... Jackson JL, O'Malley PG, Kroenke K (March 2006). "Antidepressants and cognitive-behavioral therapy for symptom syndromes". CNS ... Steele RE, de Leeuw E, Carpenter D. "A novel and effective treatment modality for medically unexplained symptoms" J Pain ... O'Malley, PG; Jackson, JL; Santoro, J; Tomkins, G; Balden, E; Kroenke, K (December 1999). "Antidepressant therapy for ...
Surgery, if feasible, is the only curative therapy. If the tumor has metastasized (most commonly, to the liver) and is ... Interferon treatment is also effective, and usually combined with somatostatin analogues.. As the metastatic potential of a ... considered incurable, there are some promising treatment modalities, such as radiolabeled octreotide [5] (e.g. Lutetium (177Lu ...
Ultrasound therapy: First introduced as a treatment modality in 1992, it involves the application of high-frequency sound waves ... Multidisciplinary approach (HBO + Surgery): Studies have shown support of combining HBO therapy and a surgical approach to ... while combined with debridement. Hyperbaric oxygen therapy (HBO): First described in 1973, HBO was intended to be an adjunctive ... which is likely attributable to improvements in radiation therapy. Radiation therapy destroys cancer primarily by causing DNA ...
This includes the modalities dance therapy, drama therapy, art therapy, music therapy, writing therapy, among others. ... Cognitive behavioral therapy attempts to combine the above two approaches, focused on the construction and reconstruction of ... multimodal therapy, and therapies for specific disorders including PTSD therapies such as cognitive processing therapy and EMDR ... In African countries this includes harmony restoration therapy, meseron therapy and systemic therapies based on the Ubuntu ...
It is clear that strategically integrating immune-based therapies with standard cancer treatment modalities, in particular ... Chemoimmunotherapy is chemotherapy combined with immunotherapy. Chemotherapy uses different drugs to kill or slow the growth of ... whereas systemic therapies (chemotherapy, endocrine therapy, molecularly targeted therapies, and adjunctive therapies ( ... Combination of different therapies in cancer has become a trend, not just between different types of therapies, also multiple ...
Current treatment modalities include oral terbinafine, oral itraconazole, and intermittent "pulse therapy" with oral ... Topical treatment by occlusive dressing combining 20% urea paste with 2% tolnaftate have also shown promise in softening the ... Gupta, AK; Daigle, D; Paquet, M (17 July 2014). "Therapies for Onychomycosis: A Systematic Review and Network Meta-Analysis of ... These infections are usually unresponsive to topical treatments and respond only to systemic therapy. Although it is most ...
Palliative treatment consists of radiation therapy usually combined with chemotherapy. The use of tracheostomy as part of ... and if combined modality treatment is used. Treatment of anaplastic thyroid cancer is generally palliative in its intent due to ... Combinatorial therapy that is molecular-based may lead to significant tumor regression, potentially making patients amenable to ... Recent advances show that using a combination of novel targeted therapies, immunotherapy, and surgery, 1 year and 2 year ...
... poetry therapy or therapeutic storytelling) is a creative arts therapies modality that involves storytelling or the reading of ... Bibliotherapy is often combined with writing therapy. It has been shown to be effective in the treatment of depression. A 3 ... The United Kingdom, beginning in the 1930s, also began to show growth in the use in of reading therapy in hospital libraries. ... Clarke, J.M. (1984). "Reading therapy - an outline of its growth in the UK". In Jean M. Clarke; Eileen Bostle (eds.). Reading ...
... to evaluate the potential clinical benefit of combining PROSTVAC with different treatment modalities such as hormonal therapies ... Based on non-clinical data supporting the scientific rationale for combination therapy with PROSTVAC, additional clinical ...
Examples include immuno-augmentation therapy, shark cartilage, bioresonance therapy, oxygen and ozone therapies, and insulin ... since there is a growing body of research on some of these modalities, and some aspects of standard care do not have a strong ... of extravagant claims by the alternative medical community combined with inadequate media scrutiny and attacks on critics.[122] ... Prevalence of use of specific therapies. The most common CAM therapies used in the US in 2002 were prayer (45%), herbalism (19 ...
PET has an expanding role as a method to assess the response to therapy, in particular, cancer therapy,[57] where the risk to ... April 2005). "Radiation exposure of patients undergoing whole-body dual-modality 18F-FDG PET/CT examinations". J. Nucl. Med. 46 ... combined with a positron emission tomograph (PET). Presently, only the head and brain can be imaged at these high magnetic ... Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy. Boca Raton: CRC Press. pp. 156-159.. ...
Hormonal treatments for acne such as combined birth control pills and antiandrogens may be considered a first-line therapy for ... PDT has the most supporting evidence of all light therapy modalities.[77] ... Combination therapy[edit]. Combination therapy-using medications of different classes together, each with a different mechanism ... The evidence for light therapy as a treatment for acne is weak and inconclusive.[8][155] Various light therapies appear to ...
... and other manual therapies to the joints and soft tissues, rehabilitative exercises, health promotion, electrical modalities, ... "Combined chiropractic interventions for low-back pain". Cochrane Database of Systematic Reviews (4): CD005427. doi:10.1002/ ... Chiropractic overlaps with several other forms of manual therapy, including massage therapy, osteopathy, physical therapy, and ... The main chiropractic treatment technique involves manual therapy, especially spinal manipulation therapy (SMT), manipulations ...
Combined Estrogen-progestogen Contraceptives and Combined Estrogen-progestogen Menopausal Therapy. World Health Organization. ... therapeutic modalities that reduce androgen signaling in the prostate gland, referred to collectively as androgen deprivation ... Katsambas AD, Dessinioti C (2010). "Hormonal therapy for acne: why not as first line therapy? facts and controversies". Clin. ... See also: Management of prostate cancer § Hormonal therapy, and Androgen deprivation therapy ...
The creation and expansion of music therapy as a treatment modality thrived in the early to mid 1900s and while a number of ... Schlez A, Litmanovitz I, Bauer S, Dolfin T, Regev R, Arnon S (June 2011). "Combining kangaroo care and live harp music therapy ... Types of music therapyEdit. There are two fundamental types of music therapy: receptive music therapy and active music therapy ... including Therapy in Music for Handicapped Children, Creative Music Therapy, Music Therapy in Special Education, as well as ...
A study was conducted regarding the recidivism rate of inmates receiving MMT (Methadone Maintenance Therapy). This therapy is ... When combined with substance misuse this increases the risk of reoffending significantly.[55] A subset of ASPD, or a related ... state and federal judges have sentenced offenders to learn the Transcendental Meditation program as an anti-recidivism modality ... "International Journal of Offender Therapy and Comparative Criminology. 48 (2): 133-48. doi:10.1177/0306624X03259472. PMID ...
This suggests that the auditory modality can access the motor system.[46][47] While these auditory-motor interactions have ... but little is known about their combined interaction in producing a complex musical performance.[18] The study of music ... Neurologic music therapy. *Neuronal encoding of sound. *Performance science. *Philosophy of music ... Arrhythmia in the auditory modality is defined as a disturbance of rhythmic sense; and includes deficits such as the inability ...
In contrast and by distinction, audio therapy is provided as a self-service modality, through which the listener is purported ... the Hirsch, C. R., Clark, D. M., and Mathews, A., Imagery and interpretations in social phobia: Support for the combined ... One such discipline is cognitive behavioral therapy. Unlike music therapy, but similar to audio therapy, the most important ... as well as art therapy, music therapy, and dance therapy. Although the means by which the mind affects the body is largely ...
... or polytherapy is therapy that uses more than one medication or modality . Typically, the term refers to ... Monotherapy has advantages over combining medications in many patients, including absence of drug-drug interactions, fewer side ... although it can also involve non-medical therapy, such as the combination of medications and talk therapy to treat depression ... "Combination Therapies for Cancer - Annual Plan". National Cancer Institute. Retrieved 2017-10-03.. ...
Both positive[71][72] and negative[11][73][74] results have been reported with adjuvant radiation therapy in this setting, and ... Ultrasound of the liver and biliary tree is often used as the initial imaging modality in people with suspected obstructive ... Knox JJ, Hedley D, Oza A, Feld R, Siu LL, Chen E, Nematollahi M, Pond GR, Zhang J, Moore MJ (April 2005). "Combining ... Adjuvant therapy followed by liver transplantation may have a role in treatment of certain unresectable cases.[70] ...
Bilateral anterolateral thoracotomy combined with transverse sternotomy results in the "clamshell" incision ... been found to be a good adjunct in the management of moderate to severe post-thoracotomy pain and effective as a lone modality ... Respiratory therapy/. intubation. *Artificial respiration. *CPR. *Hyperbaric medicine. *Decompression chamber. *Heliox. * ...
... this therapy modality is well supported by clinical evidence.[citation needed] The success of exposure-based therapies has ... Hetrick SE, Purcell R, Garner B, Parslow R (July 2010). "Combined pharmacotherapy and psychological therapies for post ... cognitive restructuring therapy, trauma-focused cognitive behavioral therapy, brief eclectic psychotherapy, narrative therapy, ... Exposure therapy is a type of cognitive behavioral therapy[157] that involves assisting trauma survivors to re-experience ...
... occupational therapy, physical therapy, biomedical research, and alternative medicine,[5][unreliable medical source?] all of ... Clinical informaticians use their knowledge of patient care combined with their understanding of informatics concepts, methods ... supporting the flow of patient information through various modalities of care. ... Seg8 Family/Prenatal/Cumulative Health/Medical/Dental Nursing History, Seg14D Therapies ● S.15 Health guidance. ● Seg10 Care/ ...
Enzyme replacement therapy. Certain lysosomal storage diseases are treated with infusions of a recombinant enzyme (produced in ... Referral to an out-patient genetics clinic (pediatric, adult, or combined) or an in-hospital consultation, most often for ... translational research on new treatment modalities, and the impact of genetic testing ... In other cases, infusion therapy is used to replace the missing enzyme. Current research is actively seeking to use gene ...
... such as pathologic stage and recurrence after surgery or radiation therapy. Most combine stage, grade, and PSA level, and some ... Therefore, there is currently much interest in the role of aggressive prostate cancer treatment modalities such as with surgery ... Active surveillance, surgery, radiation therapy, hormone therapy, chemotherapy[2]. Prognosis. 5-year survival rate 99% (US)[4] ... Androgen ablation therapy causes remission in 80-90% of patients undergoing therapy, resulting in a median progression-free ...
Common treatment modalities[edit]. The following are commonly modalities of management for retinal disease: *Intravitreal ... Rolling, F. (2004). "Recombinant AAV-mediated gene transfer to the retina: gene therapy perspectives". Gene Therapy. 11 (S1): ... A third view of the "inverted" vertebrate eye is that it combines two benefits: the maintenance of the photoreceptors mentioned ... "Human Gene Therapy. 20 (9): 999-1004. doi:10.1089/hum.2009.086. PMC 2829287. PMID 19583479.. ...
Combined modality chemotherapy is the use of drugs with other cancer treatments, such as surgery, radiation therapy, or ... Systemic therapy is often used in conjunction with other modalities that constitute local therapy (i.e. treatments whose ... Importantly, the use of drugs (whether chemotherapy, hormonal therapy or targeted therapy) constitutes systemic therapy for ... Cytotoxics and targeted therapies[edit]. Targeted therapies are a relatively new class of cancer drugs that can overcome many ...
No randomized controlled trials have been performed to compare the different treatment modalities.[1][17] Surgery is only used ... Anticoagulation is regarded as more powerful than antiplatelet therapy, but anticoagulants may increase the size of the ... the combined mortality with either treatment is 1.8-2.1%.[1][17] ... Various diagnostic modalities exist to demonstrate blood flow ... Treatment is focused on reducing stroke episodes and damage from a distending artery.[3] Four treatment modalities have been ...
Antibody testing may be combined with HLA testing if the diagnosis is unclear. TGA and EMA testing are the most sensitive serum ... Schuppan D, Junker Y, Barisani D (December 2009). "Celiac disease: from pathogenesis to novel therapies". Gastroenterology. 137 ... Three main approaches have been proposed as new therapeutic modalities for coeliac disease: gluten detoxification, modulation ... Selenium malabsorption in coeliac disease, combined with low selenium content in many gluten-free foods, confers a risk of ...
"Skin Therapy Lett (Review). 18 (7): 5-9. PMID 24305753. Archived from the original on 2016-01-31.. ... In addition, one study found that systemic glucocorticoids combined with antihistamines did not hasten the time to symptom ... "Influence of initial treatment modality on long-term control of chronic idiopathic urticaria". PLoS ONE. 8 (7): e69345. doi ... The mainstay of therapy for both acute and chronic hives is patient education, avoiding triggers and using antihistamines. ...
Grammar - This involves the ability to combine words into grammatically correct sentences (syntax) and to combine parts of ... Gathercole, Susan E. (25 July 2016). "Word learning in language-impaired children". Child Language Teaching and Therapy. 9 (3 ... and two modalities (comprehension and production). Children scoring in the lowest 10% on two or more composite scores are ... "Child Language Teaching and Therapy. 23 (1): 67-93. doi:10.1191/0265659007072143. S2CID 49573186.. ...
Facticity is a concept defined by Sartre in Being and Nothingness as the in-itself, which delineates for humans the modalities ... "Existential-therapy.com. Archived from the original on 2010-01-07. Retrieved 2010-03-08.. ... held that human existence must always be defined as the individual person combined with the concrete circumstances of his life ... Main article: Existential therapy. A major offshoot of existentialism as a philosophy is existentialist psychology and ...
Gestalt therapy[edit]. Gestalt psychology should not be confused with the Gestalt therapy, which is only peripherally linked to ... These laws deal with the sensory modality of vision. However, there are analogous laws for other sensory modalities including ... Similarities between symmetrical objects increase the likelihood that objects are grouped to form a combined symmetrical object ... Joe Wysong/Edward Rosenfeld (eds): An Oral History of Gestalt Therapy, Highland, New York 1982, The Gestalt Journal Press, p. ...
This contrast medical imaging modality is clinically used throughout the world,[32] in particular for echocardiography in the ... In angiology or vascular medicine, duplex ultrasound (B Mode imaging combined with Doppler flow measurement) is used to ... Metastatic thyroid cancer neck lymph nodes: The other thyroid therapy use for HFUS is to treat metastatic thyroid cancer neck ... Color Doppler images are generally combined with grayscale (B-mode) images to display duplex ultrasonography images. Uses ...
Sensory processing therapy[edit]. This therapy retains all of the above-mentioned four principles and adds:[45] ... The senses provide information from various modalities-vision, audition, tactile, olfactory, taste, proprioception, ... The main form of sensory integration therapy is a type of occupational therapy that places a child in a room specifically ... Sensory Integration Therapy and Auditory Integration Therapy" (PDF).. *^ "Sensory Processing Disorder (SPD) and Social Security ...
規律的體能鍛煉,特別是有氧運動,對於患有ADHD的兒童及成人而言也是有效的附加療法(英語:adjunct therapy),特別是配合興奮劑藥物治療時更是如此,不過針對改善徵狀,最理想的運動種類及強度還不清楚[164][165][166]。長期規律有氧運 ... Effect of treatment modality on long-term outcomes in attention-deficit/hyperactivity disorder: a systematic review. PLOS
When initiating warfarin therapy ("warfarinization"), the doctor will decide how strong the anticoagulant therapy needs to be. ... No specific treatment is available, but some modalities are under investigation.[45] ... The risks of bleeding are increased further when warfarin is combined with antiplatelet drugs such as clopidogrel, aspirin, or ... Gage BF, Fihn SD, White RH (October 2000). "Management and dosing of warfarin therapy". The American Journal of Medicine. 109 ( ...
See also ,b>adjuvant therapy,/b>,,b> neoadjuvant therapy, chemotherapy,/b>. ... combined modality therapy. Phonetic. mo-,b,dal,/b,-ih-tee. Description. 2 or more types of treatment used alternately or ...
Cervical Cancer Radiation Response Small Cell Lung Cancer Cell Combine Modality Therapy Human Ovarian Cancer Cell Line These ... Sersa G, Kranjc S, Cemazar M. Improvement of combined modality therapy with cisplatin and radiation using electroporation of ... Modification of Radiosensitivity Following Chemotherapy Exposure: Potential Implications for Combined-Modality Therapy. ... Potential Implications for Combined-Modality Therapy. In: Andersson B., Murray D. (eds) Clinically Relevant Resistance in ...
Idarubicin Based Combined Modality Therapy in Primary CNS Lymphoma. The safety and scientific validity of this study is the ... Combined modality therapy in PCNSL has improved survival outcomes but at the cost of unacceptable rates of neurotoxicity when ... A Phase 2 Study of Idarubicin Based Combined Modality Therapy in Primary Central Nervous System Lymphoma. ... By combining these 2 drugs with moderate dose radiotherapy survival outcomes should be optimal but with lower rates of ...
Combined-modality therapy for 150 cases of early-stage Hodgkins lymphoma were found in PRIME PubMed. Download Prime PubMed App ... Combined-modality Therapy for 150 Cases of Early-stage Hodgkins Lymphoma]." Zhonghua Zhong Liu Za Zhi [Chinese Journal of ... Combined-modality Therapy for 150 Cases of Early-stage Hodgkins Lymphoma]. Zhonghua Zhong Liu Za Zhi. 2008;30(8):630-4. PubMed ... Combined-modality therapy for 150 cases of early-stage Hodgkins lymphoma].. Zhonghua Zhong Liu Za Zhi 2008; 30(8):630-4ZZ ...
Combined-modality approaches for the treatment of non-small-cell lung cancer (NSCLC), head and neck cancer, and esophageal ... combined-modality therapy.. Background. The taxanes are a class of antineoplastic agents, derived from plants, that. have ... Mauer AM, Haraf DC, Ferguson MK, et al: Docetaxel-based combined modality. therapy for locally advanced carcinoma of the ... have included single modalities such as surgery, radiation, or chemotherapy.. Combined modality approaches offer a theoretical ...
... when combined with radiotherapy and/or surgery in the treatment of patients with head and neck cancer, appears to be most ... This paper presents an overview of the results of randomized trials of combined-modality therapy for advanced head and neck ... Lo TC, Wiley AL, Jr., Ansfield FJ, et al: Combined radiation therapy and 5-fluorouracil for advanced squamous cell carcinoma of ... Adelstein DJ, Sharan VM, Earle AS, et al: Simultaneous versus sequential combined technique therapy for squamous cell head and ...
Multi-Modality Therapy combines more than one method of mesothelioma cancer treatment. See latest statistics on lab testing and ... Tri-modality mesothelioma treatment combines several different types of therapies. The goal is to attack mesothelioma from ... Surviving Mesothelioma / News / Multi-Modality Therapy. Inflammation Protein May Impact Drug Therapies for Mesothelioma May 24 ... Triple-Modality Therapy May Improve Mesothelioma Outcomes, Study Suggests April 18, 2021. Alex Strauss ...
Modern surgical oncology is characterized by multimodal therapy. In recent years numerous therapeutic approaches of pre-, peri ... Combined Therapy in Gastric Cancer. * Phase-III Clinical Trial of Adjuvant FAM2 (5-FU, Adriamycin and Mitomycin C) vs Control ... Combined Therapy in Esophageal Cancer. * The Value of Preoperative Radiotherapy in Esophageal Cancer: Results of a Study by the ... Combined Therapy in Colorectal Cancer. * Adjuvant Portal Infusion Chemotherapy in Colorectal Cancer ...
A Phase II Study of Combine Modality Therapy in Locally Advanced Pancreatic Cancer. The safety and scientific validity of this ... Because patients with immune deficiency are at increased risk of lethal infections when treated with marrow-suppressive therapy ... Appropriate studies will be undertaken in patients receiving combination anti-retroviral therapy when indicated. ... HIV-positive patients receiving combination anti-retroviral therapy are excluded from the study because of possible ...
I. To evaluate whether therapy with nivolumab following combined modality therapy (CMT) improves disease-free survival (DFS) ... Nivolumab After Combined Modality Therapy in Treating Patients With High Risk Stage II-IIIB Anal Cancer. The safety and ... A Randomized Phase II Study of Nivolumab After Combined Modality Therapy (CMT) in High Risk Anal Cancer. ... This randomized phase II clinical trial studies how well nivolumab after combined modality therapy works in treating patients ...
In view of the complexity of biological responses to cancer therapy, this communication reports on a ... Organ toxicity in cancer therapy is likely caused by an underlying disposition for given pathophysiological mechanisms in the ... Ree AH, Meltzer S, Flatmark K, Dueland S, Kalanxhi E. Biomarkers of Treatment Toxicity in Combined-Modality Cancer Therapies ... Biomarkers of Treatment Toxicity in Combined-Modality Cancer Therapies with Radiation and Systemic Drugs: Study Design, ...
"Combined Modality Therapy" by people in this website by year, and whether "Combined Modality Therapy" was a major or minor ... "Combined Modality Therapy" by people in Profiles.. * Ko EC, Formenti SC. Radiation therapy to enhance tumor immunotherapy: a ... "Combined Modality Therapy" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are MeSH descriptors whose meaning is more general than "Combined Modality Therapy". ...
Adjuvant Therapy for Non-Small Cell Lung Cancer14:58. Combined Modality Therapy For Locally Advanced Non-Small Cell Lung Cancer ... Combined Modality Therapy For Locally Advanced Non-Small Cell Lung Cancer. To view this video please enable JavaScript, and ... This lecture is going to be dealing with the combined-modality therapy for patients with locally advanced non-small cell lung ... Majority of people will undergo combined-modality therapy with a curative intent. Cure is achieved in approximately 20 percent ...
Functional and quality-of-life outcomes in patients with rectal cancer after combined modality therapy, intraoperative ... The majority of patients with advanced rectal cancers who require external beam radiation therapy, extensive pelvic surgery, ... Locally advanced primary and recurrent rectal cancers treated with external beam radiation therapy, intraoperative radiation ... and intraoperative radiation therapy report unfavorable functional and quality-of-life outcomes after sphincter preservation. ...
Blanke, C. D. ; Choy, H. ; Leach, S. D. / Combined modality therapy for esophageal cancer. In: Seminars in Radiation Oncology. ... Blanke, C. D., Choy, H., & Leach, S. D. (1997). Combined modality therapy for esophageal cancer. Seminars in Radiation Oncology ... Blanke, CD, Choy, H & Leach, SD 1997, Combined modality therapy for esophageal cancer, Seminars in Radiation Oncology, vol. 7 ... Combined modality therapy for esophageal cancer. Seminars in Radiation Oncology. 1997;7(3 SUPPL. 2):15-23. ...
What is combined modality therapy? Meaning of combined modality therapy medical term. What does combined modality therapy mean? ... Looking for online definition of combined modality therapy in the Medical Dictionary? combined modality therapy explanation ... Combined modality therapy, Concentration therapy, Concept therapy, Condom therapy, Confrontation therapy, Conservative therapy ... neoadjuvant therapy in single-agent therapy or combined modality therapy for cancer, initial use of one modality, such as ...
The pattern of recurrence and survival after treatment failure in patients with rectal cancer treated with combined modality ... of recurrence and survival after treatment failure in patients with rectal cancer treated with combined modality therapy. ... Although surgery is the cornerstone curative treatment, combined modalities with radiotherapy and or chemotherapy have been ... The definitive treatment with the combined modalities including surgery, radiotherapy, and chemotherapy have significantly ...
We posit that this combined-modality therapy is ideally suited to geographically-remote centers such as our own. ... The autoimmune form of PAP is the most common, indicating that therapy with GM-CSF may play an important role for many patients ... Additional sequential lobar lavage and continued GM-CSF therapy as an outpatient resulted in complete resolution of oxygen ... Treatment with WLL may be impractical in some clinical settings due to the expertise and salvage modalities required. ...
Combined modality therapy of esophageal cancer. Together they form a unique fingerprint. * Combined Modality Therapy Medicine ... Combined modality therapy of esophageal cancer. / Juergens, Rosalyn A.; Forastiere, Arlene.. In: JNCCN Journal of the National ... Combined modality therapy of esophageal cancer. JNCCN Journal of the National Comprehensive Cancer Network. 2008 Oct;6(9):851- ... Combined modality therapy of esophageal cancer. In: JNCCN Journal of the National Comprehensive Cancer Network. 2008 ; Vol. 6, ...
Blanke, C., & Johnson, D. H. (1995). Combined modality therapy in non-small cell lung cancer. Current Opinion in Oncology, 7(2 ... Blanke, C & Johnson, DH 1995, Combined modality therapy in non-small cell lung cancer, Current Opinion in Oncology, vol. 7, ... Blanke, Charles ; Johnson, D. H. / Combined modality therapy in non-small cell lung cancer. In: Current Opinion in Oncology. ... title = "Combined modality therapy in non-small cell lung cancer",. abstract = "Lung cancer kills more Americans annually than ...
Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology ... Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology ... Mohiuddin, M; Winter, K; Mitchell, E; Hanna, N; Yuen, A; Nichols, C; Shane, R; Hayostek, C; Willett, C; Radiation Therapy ... 120 hours per week plus irinotecan 50 mg/m2 once weekly for 4 weeks plus pelvic radiation therapy 50.4 to 54 Gy at 1.8 Gy per ...
For example, treating a patient with chemotherapy and involved field radiation therapy is a combined modality therapy. ... Combined Modality Therapy. Two or more types of treatment used alternately or at the same time to treat a patients disease. ... Induction therapy The initial treatment with chemotherapy (or radiation therapy). The aim of induction therapy is to kill a ... Postremission Therapy. The treatment given to ALL patients after induction therapy. Postremission therapy may have two parts: ...
Combined modality therapy. The third area of biology we are focused on is referred to as combined modality therapy. Our goal is ... We are examining circulating miRNA for response to therapy and metastatic potential using a relatively non-invasive method. And ... center at UT Southwestern that includes the construction of a proton therapy center as well as a heavy particle therapy center ... and medicine that will contribute to the use of heavy particles for therapy. We are collaborating with the GSI Helmholtz Centre ...
... The download combined modality therapy of of Malory ... This recipient public download combined modality therapy of, of gp, is moved in the Idyll. This download combined modality will ... Can I use or Exchange a download combined modality therapy of central after I suggest it? Because the download combined ... The download combined modality therapy and formula of Lancelot pass up to the later paper of his language. But this course is ...
Single-modality therapy does not have a major impact on long-term survival and combined-modality therapies are being further ... Combined-modality therapy. Even 30 years ago, it was clear that MPM is difficult to treat and that, for most patients, there is ... Is trimodal therapy a valid option for patients with mesothelioma that is technically resectable? Different combined-modality ... Further prospective trials are required to determine optimal combined modality therapy in mesothelioma. Hopefully, the ...
Combined Modality Therapy. Most times, pancreatic cancer is discovered at an advanced stage. Surgery may not be appropriate in ... Radiation Therapy. This is the use of radiation to kill cancer cells and shrink tumors. Radiation therapy may be:. *External- ... The physical exam combined with all of your test results, will help to determine the stage of cancer you have. Staging is used ... Biological Therapy. The use of medications or substances made by the body. They can increase or restore the bodys natural ...
Combined modality therapy for thoracic and head and neck cancers: A review of updated literature based on a consensus meeting. ... Combined modality therapy for thoracic and head and neck cancers : A review of updated literature based on a consensus meeting. ... T1 - Combined modality therapy for thoracic and head and neck cancers. T2 - A review of updated literature based on a consensus ... Combined modality therapy for thoracic and head and neck cancers: A review of updated literature based on a consensus meeting. ...
Each modality has its proponents, but, to our knowledge, no comparative studies have been conducted in animals … ... Combined Modality Therapy * Drainage * Female * Goats * Interleukin-1 / analysis * Knee Joint* * Male ... Each modality has its proponents, but, to our knowledge, no comparative studies have been conducted in animals. We used ... Evaluation of treatment modalities for septic arthritis with histological grading and analysis of levels of uronic acid, ...
Combined Modality Therapy (CMT). CMT is a term gaining popularity and meaning several treatments at once or in succession. ... Combined Modality Therapy (CMT). CMT is a term gaining popularity and meaning several treatments at once or in succession. ... Radiation Therapy. Radiation therapy uses radiation to kill cancer cells and shrink tumors. Radiation is most often ... Radiation Therapy. Radiation therapy uses radiation to kill cancer cells and shrink tumors. Radiation is most often ...
Combined modality therapy of gastrointestinal tract cancer / P. Schlag, P. Hohenberger, U. Metzger (eds.) Contributor(s): ... Combined modality therapyNLM classification: WI 149 Tags from this library: No tags from this library for this title. Add tag(s ...
  • Exploitable mechanisms in combined radiotherapy-chemotherapy: the concept of additivity. (springer.com)
  • Idarubicin combined with high dose methotrexate and moderate dose radiotherapy will achieve similar survival outcomes but with reduced neurotoxicity compared to regimens using methotrexate with high dose radiotherapy. (clinicaltrials.gov)
  • Combined modality therapy in PCNSL has improved survival outcomes but at the cost of unacceptable rates of neurotoxicity when high dose radiotherapy is used. (clinicaltrials.gov)
  • By combining these 2 drugs with moderate dose radiotherapy survival outcomes should be optimal but with lower rates of neurotoxicity. (clinicaltrials.gov)
  • To compare the efficacy of chemotherapy alone, radiotherapy alone and combined-modality therapy in the treatment for early-stage Hodgkin's lymphoma (HL). (unboundmedicine.com)
  • They were stratified into several groups based on initial treatment strategy: chemotherapy alone (CT group, n = 22), radiotherapy alone (RT group, n = 18), combined-modality therapy (CMT group, n = 109) and surgical resection (SR group, n = 1). (unboundmedicine.com)
  • Combined-modality therapy is more effective than chemotherapy alone or radiotherapy alone in the treatment for early stage Hodgkin's lymphoma. (unboundmedicine.com)
  • A Canadian study suggests that triple-modality therapy with radiotherapy, immunotherapy, and surgery may extend the lives of people with malignant pleural mesothelioma. (survivingmesothelioma.com)
  • Although surgery is the cornerstone curative treatment, combined modalities with radiotherapy and or chemotherapy have been proved to be an important component of treatments for locally advanced rectal cancer including Stage II and Stage III in terms of decreased local recurrence and increased overall survival in addition to surgical resection. (alliedacademies.org)
  • Although total mesorectal excision (TME) has resulted in a significant reduction of local recurrence, neoadjuvant or adjuvant radiotherapy with or without chemotherapy is still an important modality for local control in the era of TME. (alliedacademies.org)
  • The definitive treatment with the combined modalities including surgery, radiotherapy, and chemotherapy have significantly improved the treatment outcomes of patients with rectal cancer but cancer recurrence of both local regional and distant is still significant ( 1 - 9 ). (alliedacademies.org)
  • Majority of the patients received tri-modality of treatments either neoadjuvant chemo-radiotherapy followed by definitive surgery (n=152) or surgery followed by adjuvant chemo-radiotherapy (n=117). (alliedacademies.org)
  • After aggressive treatments which included surgical resection alone or combined with radiotherapy and or chemotherapy, long term survivors were identified with 3 patients who had isolated local recurrence and who have survived 8 to 11 years without evidence of further recurrence. (alliedacademies.org)
  • Seung, SK & Ross, HJ 2009, ' Phase II Trial of Combined Modality Therapy With Concurrent Topotecan Plus Radiotherapy Followed by Consolidation Chemotherapy for Unresectable Stage III and Selected Stage IV Non-Small-Lung Cancer ', International Journal of Radiation Oncology Biology Physics , vol. 73, no. 3, pp. 802-809. (elsevier.com)
  • Comparative effectiveness of radical prostatectomy with adjuvant radiotherapy versus radiotherapy plus androgen deprivation therapy for men with ad. (nih.gov)
  • Clinical guidelines support multimodal approaches, which include radical prostatectomy (RP) followed by radiotherapy (XRT) and XRT plus androgen deprivation therapy (ADT). (nih.gov)
  • Capecitabine has also been investigated in a variety of protocols in rectal and other gastrointestinal cancers in combination with radiotherapy [ 16 ], with equivalence of capecitabine plus radiotherapy and 5-FU plus radiotherapy as preoperative therapy in locally advanced rectal cancer being demonstrated in the systematic review by Saif et al. (springer.com)
  • A prospective study of the safety and efficacy of liver stereotactic body radiotherapy in patients with and without prior liver-directed therapy. (unc.edu)
  • Anal Carcinoma Therapy: Can We Improve on 5-Fluorouracil/Mitomycin/Radiotherapy? (jnccn.org)
  • stages II-IV) were treated with definitive chemoradiotherapy using 5-fluorouracil and cisplatin combined with radiotherapy. (aacrjournals.org)
  • A phase III trial from the United States (Radiation Therapy Oncology Group trial 85-01) showed that adding 5-fluorouracil and cisplatin (FP) combination chemotherapy to radiotherapy is superior to radiotherapy alone in patients with locally advanced esophageal cancer ( 1 - 3 , 5 , 6 ). (aacrjournals.org)
  • In view of the complexity of biological responses to cancer therapy, this communication reports on a "top-down" strategy, starting with the systematic assessment of adverse effects within a defined therapeutic context and proceeding to transcriptomic and proteomic analysis of relevant patient tissue samples and computational exploration of the resulting data, with the ultimate aim of utilizing information from functional connectivity networks in evaluation of patient safety in multimodal cancer therapy. (mdpi.com)
  • Hoag's committed to accurate diagnosis, combined with progressive therapeutic options enables Hoag patients to achieve some of the highest clinical outcomes in the nation. (hoag.org)
  • This model recapitulates radiation-resistant prostate cancers which can be used to demonstrate and quantify therapeutic response to combined modality treatments. (elsevier.com)
  • A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. (bioportfolio.com)
  • Thus, the positive impact of IORT on local control of colorectal cancer appears to justify the inclusion of this therapeutic modality. (aetna.com)
  • Many targeted therapies are examples of immunotherapy (using immune mechanisms for therapeutic goals) developed by the field of cancer immunology. (wikipedia.org)
  • 1] The survival for those with early-stage disease (T1-2, N0, M0) is acceptable, with 5-year survival rates of 70% to 90% with single-modality therapy. (cancernetwork.com)
  • Locally or regionally advanced (T3-4, N0-3) disease has historically been treated with combined-modality therapy to maximize local control and survival. (cancernetwork.com)
  • The addition of surgery following primary combined-modality therapy apparently does not improve survival, but this finding is controversial. (cancernetwork.com)
  • I. To evaluate whether therapy with nivolumab following combined modality therapy (CMT) improves disease-free survival (DFS) compared with observation in patients with high risk anal carcinoma. (clinicaltrials.gov)
  • Stage III non-small cell is a curable disease with a five-year overall survival rate in the 15-25 percent range with current therapy. (coursera.org)
  • results have been equivocal, with response and survival rates similar to those of single modality therapy. (elsevier.com)
  • Some studies evaluating chemotherapy followed by surgery have resulted in improved partial response rates (17%-57%), with median survival similar to single modality treatment. (elsevier.com)
  • In two randomized trials, the combination of chemotherapy and surgery was not superior to single modality therapy in terms of response and survival. (elsevier.com)
  • The combined chemoradiotherapy approach, versus single-modality chemotherapy or irradiation, has improved on survival. (elsevier.com)
  • Single-modality therapy does not have a major impact on long-term survival and combined-modality therapies are being further evaluated. (ersjournals.com)
  • After surgery, follow-up chemotherapy and radiation therapy have been found to prolong survival in some cases. (epnet.com)
  • Surgery is still regarded as the principle modality among treatment strategies, with longterm survival achieved mainly in less advanced cases. (knowcancer.com)
  • A case of long-term survival due to combined modality therapy for liver metastasis of colon cancer]. (elsevier.com)
  • Systemic symptoms, histologic subtype, age, and limited extranodal involvement (E-lesions) did not affect the prognosis of patients and failed to identify patients whose survival could be improved by the routine use of combined modality therapy. (ashpublications.org)
  • Purpose: Standard therapy for patients with stage I-II indolent lymphoma has been involved-field radiation therapy (IF-XRT), which achieves 10-year disease-free survival in 40% to 50% of patients/ with many of these patients cured. (northwestern.edu)
  • We investigated the potential for combined-modality therapy to increase the disease-free survival for such patients. (northwestern.edu)
  • Conclusion: With prolonged follow-up, combined-modality therapy with risk-adapted COP-/CHOP-Bleo and IF radiation has attained higher rates of disease control and survival than previously reported with IF-XRT alone. (northwestern.edu)
  • Erlotinib has been shown to increase survival in metastatic non small cell lung cancer when used as second line therapy. (wikipedia.org)
  • Combined modality therapy of gastrointestinal tract cancer / P. Schlag, P. Hohenberger, U. Metzger (eds. (who.int)
  • Single modality therapy for esophageal cancer usually consists of surgery or radiation therapy. (elsevier.com)
  • Single-modality therapy is the standard for most cases of limited and metastatic non-small cell lung cancer, but treatment of locally advanced disease remains controversial. (elsevier.com)
  • Moreover, we do not know from these trials what is the added value of irradiation in a combined modality therapy over a preoperative chemotherapy. (knowcancer.com)
  • Freedom from relapse at 10 yr was 77% among patients treated with irradiation alone and 84% after treatment with combined modality therapy [p(Gehan) = 0.09]. (ashpublications.org)
  • Patients with large mediastinal masses (mediastinal mass ratio greater than or equal to 1/3) had a significantly poorer freedom from relapse when treated with irradiation alone than when treated initially with combined modality therapy [45% versus 81% at 10 yr, p(Gehan) = 0.03). (ashpublications.org)
  • Radiation oncology only minimally takes the genetic makeup of tumors into account, and little attention has been given to the fact that the different modalities of ionizing radiation, such as photon and proton irradiation, may also induce differential damages and biological processes, which might again be influenced by the genetic makeup and mutational status of the tumor. (allenpress.com)
  • Here we will review recent insights on the differential DNA damage responses to photon and proton irradiation and discuss their implications for combined treatment modalities with chemotherapeutical agents and small molecular targeting compounds. (allenpress.com)
  • It begins with an aggressive resection of the visible tumor then following it with Radiation Therapy (RT) given together with chemotherapy. (bcan.org)
  • Radiation therapy to enhance tumor immunotherapy: a novel application for an established modality. (umassmed.edu)
  • We report the case in which the tumor-free status can be observed as a result of a combination of systemic chemotherapy and local therapy. (elsevier.com)
  • Moreover, by combining the mRNA vaccines with therapies in clinical use (chemotherapy or anti-CTLA-4 antibody therapy), an even more effective anti-tumor response can be elicited. (wiley.com)
  • Hence, current treatment decisions for particle beam therapy are primarily based on vulnerable tumor locations near organs-at-risk, and treated entities comprise uveal melanoma, skull-based and intracranial tumors, prostate and head and neck tumors [ 8 , 9 ]. (allenpress.com)
  • Operation, chemotherapy, and rays therapy are regular modalities for tumor treatment, however the effectiveness of the treatments has already reached a plateau. (complextraitgenomics.com)
  • Management of NMIBC, traditionally, has been focused on the reduction of subsequent bladder recurrence and prevention of disease progression and is primarily based on transurethral resection (TUR) of the tumor, followed by intravesical therapy based on estimated individual risk of recurrence. (srce.hr)
  • The intent of vaccination is to induce a combined antibody and T-cell anti-HER-2 immune response, which is intended to target HER-2-expressing tumor cells, and may induce tumor regression or slow progression of disease. (stanford.edu)
  • The primary purpose of this study is to determine whether breast cancer tumors respond (as measured by pathologic complete response: the absence of microscopic evidence of invasive tumor cells in the breast) to combined chemotherapy of AC(doxorubicin and cyclophosphamide) followed by paclitaxel plus trastuzumab or lapatinib or both given before surgery to patients with HER2-positive breast cancer. (stanford.edu)
  • Depletion of Tumor Oxygenation during Photodynamic Therapy: Detection by the Hypoxia Marker EF3. (upenn.edu)
  • Intra-operative radiation therapy (IORT) is being investigated as a technique to deliver a high dose of radiation to a locally advanced tumor while attempting to protect adjacent normal tissues at the time of surgery. (aetna.com)
  • DTI assessment of the brainstem white matter tracts in pediatric BSG before and after therapy: a report from the Pediatric Brain Tumor Consortium. (harvard.edu)
  • As a form of molecular medicine, targeted therapy blocks the growth of cancer cells by interfering with specific targeted molecules needed for carcinogenesis and tumor growth, rather than by simply interfering with all rapidly dividing cells (e.g. with traditional chemotherapy). (wikipedia.org)
  • Another form of targeted therapy involves the use of nanoengineered enzymes to bind to a tumor cell such that the body's natural cell degradation process can digest the cell, effectively eliminating it from the body. (wikipedia.org)
  • The definitive experiments that showed that targeted therapy would reverse the malignant phenotype of tumor cells involved treating Her2/neu transformed cells with monoclonal antibodies in vitro and in vivo by Mark Greene's laboratory and reported from 1985. (wikipedia.org)
  • He describes the data in favor of primary chemoradiotherapy without surgery and concludes that combined use of chemotherapy and radiation is the standard of care for patients found to have squamous cell cancers or adenocarcinoma. (cancernetwork.com)
  • Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used. (umassmed.edu)
  • PURPOSE: To evaluate the rate of pathologic complete response and toxicity of neoadjuvant chemoradiation for advanced T3/T4 distal rectal cancers in a randomized phase II study PATIENTS AND METHODS: Patients with clinical T3/T4 distal rectal cancers were randomly assigned in a phase II study to receive combined neoadjuvant chemoradiotherapy followed by surgical resection. (duke.edu)
  • One of the options for improving treatment outcome in patients with advanced esophageal cancer is combined modality treatment with chemo- and chemoradiotherapy. (knowcancer.com)
  • That were the reasons for designing our trial testing 3 principal modes of esophageal cancer therapy: surgery vs. chemotherapy + surgery vs. chemoradiotherapy + surgery on homogenous population of esophageal cancer patients with single pathological type - squamous cell carcinoma affecting thoracic esophagus. (knowcancer.com)
  • Based on positive results from the Radiation Therapy Oncology Group (RTOG) 85-01 trial, the conventional nonsurgical treatment of esophageal carcinoma is combined-modality therapy. (cancernetwork.com)
  • Areas of clinical investigation include the development of combined-modality therapy regimens with newer systemic agents, the use of 18F-fluorodeoxyglucose positron-emission tomography to assist in the development of innovative radiation treatment planning techniques, and the identification of prognostic molecular markers. (cancernetwork.com)
  • Treatment approaches for operable stages of these GI cancers focus on determining the usefulness of neoadjuvant and adjuvant therapies. (cancernetwork.com)
  • A comparison of chemotherapy alone versus surgery-based tri-modality treatment for mesothelioma shows patients who take the more aggressive path tend to live much longer. (survivingmesothelioma.com)
  • Tri-modality mesothelioma treatment combines several different types of therapies. (survivingmesothelioma.com)
  • Surgery-Based Tri-Modality Mesothelioma Treatment Pleural mesothelioma is a fast-growing malignancy on the lining around the lungs. (survivingmesothelioma.com)
  • collapse therapy a formerly common treatment for pulmonary tuberculosis in which the diseased lung was collapsed in order to immobilize it and allow it to rest. (thefreedictionary.com)
  • convulsive therapy treatment of mental disorders, primarily depression, by induction of convulsions . (thefreedictionary.com)
  • Whole lung lavage (WLL) is the treatment of choice in symptomatic PAP, but transient worsening of oxygenation sometimes requires salvage modalities of support such as extracorporeal membrane oxygenation (ECMO). (biomedcentral.com)
  • Treatment with WLL may be impractical in some clinical settings due to the expertise and salvage modalities required. (biomedcentral.com)
  • The prognosis of patients with malignant pleural mesothelioma remains poor and although it is clear that multimodal therapy is necessary to improve long-term results, precise treatment schemes have not yet been unequivocally established. (ersjournals.com)
  • Further treatment options that are currently explored include hyperthermic intrapleural chemotherapy, immunotherapy, gene therapy and photodynamic therapy. (ersjournals.com)
  • Although it has not been shown that chemo- and radiation therapy at the same time are better than radiation therapy alone in the treatment of gallbladder cancer, CMT is better with many other kinds of cancers. (epnet.com)
  • The combined modality therapy approach, including the medical, surgical and radiation arms of cancer therapy, provides the best treatment options for the management of a wide variety of cancer patients with complex problems. (utsouthwestern.edu)
  • As a nationally recognized leader in state-of-the-art radiation therapies, Hoag's radiation oncology program is yet another example of the institute's commitment to excellence in innovative cancer treatment. (hoag.org)
  • Although no one has shown that chemotherapy and radiation therapy at the same time are better than radiation therapy alone in the treatment of gallbladder cancer, CMT is better with many other kinds of cancers. (hoag.org)
  • By combining different treatment modalities cell killing was further enhanced due to interacting sublethal damage. (ki.se)
  • Surgery may be the only treatment, or it may be done in combination with radiation therapy and/or chemotherapy. (upstate.edu)
  • In the guideline for the treatment of liver metastasis of colorectal cancer, even though chemotherapy is currently developed, the surgical procedure is recommended for patients who are responsive to local therapy. (elsevier.com)
  • However, radiation oncology is nowadays challenged to understand subtle differences induced by the different qualities of ionizing radiation, and to efficiently exploit and to integrate these differential responses in a personalized treatment approach alone and as part of combined treatment modalities with pharmacologic agents. (allenpress.com)
  • Complications, oncological and functional outcomes of salvage treatment options following focal therapy for localized prostate cancer: a systematic review and a comprehensive narrative review. (bioportfolio.com)
  • Radiation therapy is considered a standard treatment option for the management of localized prostate cancer. (bioportfolio.com)
  • Patients with stage III prostate cancer are curable and have a number of treatment options, including external beam radiation therapy (EBRT) with or without hormone therapy, surgical removal of the cancer with radical prostatectomy, or active surveillance without immediate treatment. (yourcancercare.com)
  • It is important for patients to obtain as much information as possible about the results of each treatment modality and to obtain more than one opinion on the matter, especially when deciding on surgery versus radiation therapy. (yourcancercare.com)
  • The current standard treatment for stage III prostate cancer is external beam radiation therapy (EBRT) in conjunction with long-term androgen deprivation therapy (ADT). (yourcancercare.com)
  • Treatment with surgery or radiation is referred to as local therapy because they treat prostate cancer in or near the prostate only. (yourcancercare.com)
  • An effective treatment is needed to cleanse the body of micrometastases in individuals at high risk of recurrence after local therapy. (yourcancercare.com)
  • Another form of treatment, usually hormone therapy, radiation therapy or participation in a clinical study is generally recommended. (yourcancercare.com)
  • Of particular interest are adjuvant therapy, treatment of metastatic disease, methods for treatment of locally advanced breast cancer and inflammatory breast cancer. (stanford.edu)
  • Encouraging outcomes have been achieved with a combined-modality treatment approach for patients with locally recurrent colorectal cancer in both curative and palliative settings, although room for im. (ascopost.com)
  • Aetna considers intraoperative radiation therapy (IORT) medically necessary for the treatment of cervical cancer, colorectal cancer, soft tissue sarcoma (including retroperitoneal sarcoma), and uterine cancer. (aetna.com)
  • Intra-operative radiation therapy is usually a component of a multi-disciplinary treatment approach for localized cancers that can not be completely removed or that have a high risk of recurring in nearby tissues. (aetna.com)
  • The Stanford Cancer Center states, 'In some cases, no further radiation treatment is required following IORT making it a much more convenient approach for delivering therapy. (aetna.com)
  • Till 1970s, surgery was the primary modality of treatment of HB. (centerwatch.com)
  • He also specializes in the treatment of esophageal tumors and has led national clinical trials in both therapy of brain tumors as well as esophageal cancer. (hopkinsmedicine.org)
  • For localized gastroesophageal cancer, progress has been made with the implementation of multidisciplinary approaches that lead to better selection of therapy for a specific patient, formulation of long-term strategies, and emergence of new standards.4-6 Multidisciplinary interactions can lead to new research strategies and improved understanding of the philosophies used by individual disciplines for treatment decisions. (jnccn.org)
  • Progress in the treatment of early gastroesophageal carcinomas using endoscopic therapies is also worth mentioning.7-10 Endoscopic therapy of early cancer seems to be spreading in non-academic centers as well. (jnccn.org)
  • His training includes international experience at the Heidelberg University Hospital in Heidelberg, Germany, focused on technique and delivery of particle therapy, specifically proton and carbon treatment. (medstarhealth.org)
  • His research focuses on the development of novel radiation therapy techniques and reduction in treatment-related side effects. (medstarhealth.org)
  • Targeted therapy or molecularly targeted therapy is one of the major modalities of medical treatment (pharmacotherapy) for cancer, others being hormonal therapy and cytotoxic chemotherapy. (wikipedia.org)
  • Functional and quality-of-life outcomes in patients with rectal cancer after combined modality therapy, intraoperative radiation therapy, and sphin. (nih.gov)
  • Randomized phase II study of neoadjuvant combined-modality chemoradiation for distal rectal cancer: Radiation Therapy Oncology Group Trial 0012. (duke.edu)
  • Use of definitive chemoradiation as primary therapy for locoregional squamous cell carcinoma of the anal canal has been the standard approach in the United States since the 1980s. (jnccn.org)
  • This article provides a critical review of the data on multi-modality approaches to the management of esophageal cancer. (elsevier.com)
  • An integrated, multi-modality imaging technique is disclosed. (google.com)
  • More particularly, the invention relates to an integrated system that makes use of different modalities in a complementary fashion to permit feedback to surgeons and other medical professionals of physical conditions of a subject, particularly during interventionary procedures. (google.com)
  • Ko E. Eric Ko on Combining Radiation Therapy With Immunotherapy to Treat Non-Small-Cell Lung Cancer. (umassmed.edu)
  • Co-targeted therapy involves the use of one or more therapeutics aimed at multiple targets, for example PI3K and MEK, in an attempt to generate a synergistic response and prevent the development of drug resistance. (wikipedia.org)
  • This article will delineate the current data available from clinical trials investigating combined-modality therapy for locally advanced head and neck carcinoma. (cancernetwork.com)
  • The Radiation Therapy Oncology Group (RTOG) conducted a randomized trial (RTOG 73-03) comparing preoperative 50 Gy to postoperative 60 Gy in 277 patients with locally advanced carcinoma of the supraglottis and hypopharynx. (cancernetwork.com)
  • A randomized trial of thymosin fraction V (60 mg/m2 s.c. twice weekly) given during induction chemotherapy and radiation therapy was performed in 91 patients with small cell carcinoma of the lung. (nih.gov)
  • I. To compare nivolumab following combined modality therapy (CMT) with observation in patients with high risk anal carcinoma with regard to objective response rate (complete [CR] and partial [PR]), stable disease and progression. (clinicaltrialsgps.com)
  • To compare nivolumab following combined modality therapy (CMT) with observation in patients with high risk anal carcinoma with regard to severe toxicity interval. (clinicaltrialsgps.com)
  • Both in a rodent (lung fibroblast) and a human solid tumour (lung carcinoma) cell line synergistic effects after combined exposures to ultrasound and radiation was found. (ki.se)
  • Another drawback of available RCTs is combining 2 different biological cancer entities: adenocarcinoma and squamous cell carcinoma of the esophagus as well as carcinoma of the esophagus and gastro-esophageal junction. (knowcancer.com)
  • [email protected]#To evaluate the efficacy of combined modality therapy for advanced hypopharyngeal carcinoma in order to improve the curative effect of hypopharyngeal carcinoma . (bvsalud.org)
  • METHOD @#Seventy-six male patients with the stage III - IV hypopharyngeal carcinoma were treated with postoperative combined modality. (bvsalud.org)
  • See also adjuvant therapy , neoadjuvant therapy, chemotherapy . (cancer.org)
  • This article reviews the role of staging, surgery, and adjuvant and preoperative therapies in the management of localized gastric and esophageal cancers. (jnccn.org)
  • Lung cancer kills more Americans annually than the next four most frequently diagnosed malignancies combined. (elsevier.com)
  • Purpose: Combined modality therapy is a mainstay option for thoracic malignancies and head and neck cancers. (elsevier.com)
  • The majority of patients with advanced rectal cancers who require external beam radiation therapy, extensive pelvic surgery, and intraoperative radiation therapy report unfavorable functional and quality-of-life outcomes after sphincter preservation. (nih.gov)
  • By combining ADT with a higher dose of EBRT delivered with 3D-CRT or IMRT radiation therapy the outcomes of stage III patients have been improved. (yourcancercare.com)
  • The most frequent side-effect of the preoperative combined therapy was dermatitis (grade 3 in 19 patients). (springer.com)
  • preoperative combined modality therapy and the matrix. (hopkinsmedicine.org)
  • Forastiere, A.A. Phase II, parallel-design study of preoperative combined modality therapy and the matrix metalloprotease (mmp) inhibitor prinomastat in patients with esophageal adenocarcinoma. (hopkinsmedicine.org)
  • Targeted cancer therapies are expected to be more effective than older forms of treatments and less harmful to normal cells. (wikipedia.org)
  • however, a direct comparison of trimodality therapy versus chemotherapy plus radiation has not been performed. (elsevier.com)
  • Locally advanced primary and recurrent rectal cancers treated with external beam radiation therapy, intraoperative radiation therapy, and chemotherapy represent a complex group of patients in the setting of extensive pelvic surgery and sphincter preservation. (nih.gov)
  • We retrospectively reviewed our experience with locally advanced primary and recurrent rectal cancer patients who underwent intraoperative radiation therapy with either low anterior resection (n = 12) or coloanal anastomosis (n = 6) between 1991 and 1998. (nih.gov)
  • Regarding the use of IORT in colon cancer, NCCN guidelines state: "Intraoperative radiation therapy, if available, should be considered for patients with T4 or recurrent cancers as an additional boost. (aetna.com)
  • For patients who present with large primary tumors or regional disease (American Joint Committee on Cancer stages III/IV), historical therapy has been surgery followed by postoperative radiation. (cancernetwork.com)
  • If they are socially about a download combined modality therapy of central nervous system tumors, we will be them consider up a new Language so they can sustain their reflection in their My Digital Library or via our Other fair nights. (sierrasignsaz.com)
  • No download combined modality therapy of central nervous system tumors art on the De Rerum Natura, as frankly and ed, is aloud immediately as this English writing in monitoring the emulsion of personal known bed in the work and language of the Roman. (sierrasignsaz.com)
  • be you for your download combined modality therapy of central nervous system tumors. (sierrasignsaz.com)
  • Methods: The Italian Association of Radiation Oncology Young Members Working Group (AIRO Giovani) organized its 8th national meeting, focused on combination therapy in lung, esophageal, and head and neck cancer (with a specific focus on larynx-preservation strategies for larynx/hypopharynx tumors), involving young professionals working in Italy. (elsevier.com)
  • Radiation therapy uses radiation to kill cancer cells and shrink tumors. (epnet.com)
  • Local iontophoretic administration of cytotoxic therapies to solid tumors. (unc.edu)
  • Wharam, M. Pre-radiation chemotherapy with response-based radiation therapy in children with central nervous system germ cell tumors: a report from the Children''s Oncology Group. (hopkinsmedicine.org)
  • Additional sequential lobar lavage and continued GM-CSF therapy as an outpatient resulted in complete resolution of oxygen requirement and return to normal pulmonary physiology. (biomedcentral.com)
  • The use of intensity-modulated radiation therapy (IMRT) is associated with fewer acute and late toxic effects than is three-dimensional conformal radiation therapy (3D-CRT) in men with localized prostate cancer, according to preliminary analysis of the Radiation Therapy Oncology Group (RTOG) 0126. (ascopost.com)
  • Induction chemotherapy followed by radiation therapy is an acceptable alternative to surgical resection for organ preservation. (cancernetwork.com)
  • The integration of different treatments in the clinical decision-making process to combine therapies is crucial. (elsevier.com)
  • Salvage Local Treatments After Focal Therapy for Prostate Cancer. (bioportfolio.com)
  • Whether focal therapy (FT) jeopardizes subsequent prostate cancer (PCa) salvage treatments, when needed, remains a major concern and is largely unknown. (bioportfolio.com)
  • For patients with operable esophageal adenocarcinoma, combined-modality therapy should include surgery. (cancernetwork.com)
  • Trimodality therapy (surgery plus radiation plus chemotherapy) with a variety of schedules also has been explored. (elsevier.com)
  • Surgery was performed 4 to 10 weeks after completion of neoadjuvant therapy. (duke.edu)
  • It is not yet known whether chemotherapy is effective in treating women who have undergone surgery and radiation therapy for relapsed breast cancer. (stanford.edu)
  • A phase I study of Foscan-mediated photodynamic therapy and surgery in patients with mesothelioma. (upenn.edu)
  • Combined modality therapy may prove of benefit for patients with AIDS-related primary CNS lymphoma. (knowcancer.com)
  • No universally accepted diagnostic criteria, laboratory tests, imaging studies or other modalities definitively diagnose or exclude burning mouth syndrome (BMS). (medscape.com)
  • Nine PCNSL patients and 11 SCNSL patients underwent whole-brain radiation therapy with 4-MV photons. (fujita-hu.ac.jp)
  • The objectives of the talk are to review the role of systemic therapy in locally advanced non-small cell and to review the role of combined-modality therapy in people with locally advanced non-small cell lung cancer. (coursera.org)
  • Topotecan is active against NSCLC, can safely be combined with RT at effective systemic doses, and can be given by continuous infusion, making it an attractive study agent against locally advanced NSCLC. (elsevier.com)
  • Dr. Lischalk specializes in proton therapy, intensity modulated radiation therapy, image guided radiation therapy, RapidArc®, CyberKnife® stereotactic body radiation therapy, and stereotactic radiosurgery. (medstarhealth.org)
  • The term "intraoperative radiation therapy" may also refer to intra-operative brachytherapy, the temporary or permanent implantation of radioactive seeds. (aetna.com)
  • The purpose of this study was to develop an aggressive locally advanced orthotopic prostate cancer model for assessing high-dose image-guided radiation therapy combined with biological agents. (elsevier.com)
  • Any investigational agent other than antiretroviral agents available by therapy IND. (knowcancer.com)
  • Carbon 11-choline positron emission tomography/computed tomography and palliative local therapy for castration-resistant prostate cancer. (bioportfolio.com)
  • Carbon 11-choline positron emission tomography/computed tomography (11C-choline PET/CT) and subsequent local therapy for oligometastatic prostate cancer have been reported to be effective, but their e. (bioportfolio.com)
  • Combined Modality Therapy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • CONCLUSION: Although the overall complete response rate and toxicity seems similar in both arms, this is the first multi-institutional study to establish a relatively high (28%) pCR rate after neoadjuvant therapy. (duke.edu)
  • A device for applying light in photodynamic therapy is arranged to apply light in a pattern corresponding to the configuration of the lesion to be treated. (google.com)
  • The present invention relates to the field of photodynamic therapy. (google.com)
  • Photodynamic therapy involves the application of light to abnormal tissues (referred to herein as "lesions") in or on the body of a human or other mammalian subject to cause regression of the lesion. (google.com)
  • In vivo Optical Properties of Norman Canine Prostate at 732 nm Using Motexafin Lutetium-mediated Photodynamic Therapy. (upenn.edu)
  • Photodynamic Therapy Creates Fluence Rate-dependent Gradients in the Intratumoral Spatial Distribution of Oxygen. (upenn.edu)
  • Intraperitoneal photodynamic therapy for peritoneal carcinomatosis and sarcomatosis. (upenn.edu)
  • More Americans will die from lung cancer each year (approximately 159,480) than from colon, breast, pancreatic, and prostate cancer combined (approximately 158,630), the next most common causes of cancer death. (coursera.org)
  • This lecture is going to be dealing with the combined-modality therapy for patients with locally advanced non-small cell lung cancer. (coursera.org)
  • Better staging systems and definitions of biologic prognostic factors may help determine the optimal therapy for locally advanced non-small cell lung cancer patients. (elsevier.com)
  • Blanke, C & Johnson, DH 1995, ' Combined modality therapy in non-small cell lung cancer ', Current Opinion in Oncology , vol. 7, no. 2, pp. 144-149. (elsevier.com)
  • Surprisingly, less may be more when it comes to radiation therapy with concurrent chemotherapy for patients with stage III non-small cell lung cancer (NSCLC), according to an interim analysis of the r. (ascopost.com)
  • Extensive histological sampling following focal therapy of clinically significant prostate cancer with high-intensity focused ultrasound. (bioportfolio.com)
  • Present the most recent advances in cancer therapy and basic cancer research from a clinical and laboratory perspective, with an emphasis on new translational research approaches. (utsouthwestern.edu)
  • In this thesis, new approaches to improve tumour therapy for patients with inoperable, radiation- and chemoresistant tumours were in focus. (ki.se)