The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA.
An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
An alkylating agent of value against both hematologic malignancies and solid tumors.
An antitumor alkaloid isolated from VINCA ROSEA. (Merck, 11th ed.)
The use of IONIZING RADIATION to treat malignant NEOPLASMS and some benign conditions.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The total amount of radiation absorbed by tissues as a result of radiotherapy.
A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
The application of probability and statistical methods to calculate the risk of occurrence of any event, such as onset of illness, recurrent disease, hospitalization, disability, or death. It may include calculation of the anticipated money costs of such events and of the premiums necessary to provide for payment of such costs.
An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
Tumors or cancer of the LUNG.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
Antineoplastic antibiotic obtained from Streptomyces peucetius. It is a hydroxy derivative of DAUNORUBICIN.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
A malignant epithelial tumor with a glandular organization.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

Adenoviral gene transfer into the normal and injured spinal cord: enhanced transgene stability by combined administration of temperature-sensitive virus and transient immune blockade. (1/14907)

This study characterized gene transfer into both normal and injured adult rat dorsal spinal cord using first (E1-/E3-) or second (E1-/E2A125/E3-, temperature-sensitive; ts) generation of replication-defective adenoviral (Ad) vectors. A novel immunosuppressive regimen aimed at blocking CD4/CD45 lymphocytic receptors was tested for improving transgene persistence. In addition, the effect of gene transfer on nociception was also evaluated. Seven days after treatment, numerous LacZ-positive cells were observed after transfection with either viral vector. By 21 days after transfection, beta-galactosidase staining was reduced and suggestive of ongoing cytopathology in both Ad-treated groups, despite the fact that the immunogenicity of LacZ/Adts appeared less when compared with that elicited by the LacZ/Ad vector. In contrast, immunosuppressed animals showed a significant (P < or = 0.05) increase in the number of LacZ-positive cells not displaying cytopathology. In these animals, a concomitant reduction in numbers of macrophages/microglia and CD4 and CD8 lymphocytes was observed. Only animals that received LacZ/Adts and immunosuppression showed transgene expression after 60 days. Similar results were observed in animals in which the L4-L5 dorsal roots were lesioned before transfection. Gene transfer into the dorsal spinal cord did not affect nociception, independent of the adenovirus vector. These results indicate that immune blockade of the CD4/CD45 lymphocytic receptors enhanced transgene stability in adult animals with normal or injured spinal cords and that persistent transgene expression in the spinal cord does not interfere with normal neural function.  (+info)

Systemic administration of rIL-12 synergistically enhances the therapeutic effect of a TNF gene-transduced cancer vaccine. (2/14907)

Interleukin-12 (IL-12) is a potent antitumor cytokine, which induces and enhances the activity of natural killer (NK) cells, lymphokine activated killer (LAK) cells and cytotoxic T lymphocytes (CTL). IL-12 also stimulates IFN-gamma production from both T cells and NK cells. In this study, we transfected methylcholanthrene-induced fibrosarcoma (MCA-D) with TNF gene and investigated the therapeutic effect of TNF gene-transduced cancer vaccine and whether the vaccination effect is enhanced by systemic administration of recombinant IL-12 (rIL-12), in a murine model. TNF gene-transduced cancer vaccine or systemic administration of rIL-12 showed slight or moderate inhibition of pre-established tumor. However, simultaneous application of the vaccine and rIL-12 resulted in complete eradication. The cytotoxicity of CTL against parental tumor cells was enhanced with the combination of the vaccine and rIL-12, and IFN-gamma production from spleen cells also increased synergistically. Our findings show that synergistic enhancement of CTL activity and IFN-gamma production could play an important role in the antitumor effect of combination therapy using TNF gene-transduced cancer vaccine and rIL-12.  (+info)

Reirradiation combined with hyperthermia in recurrent breast cancer results in a worthwhile local palliation. (3/14907)

Both experimental and clinical research have shown that hyperthermia (HT) gives valuable additional effects when applied in combination with radiotherapy (RT). The purpose of this study was evaluation of results in patients with recurrent breast cancer, treated at the Daniel den Hoed Cancer Center (DHCC) with reirradiation (re-RT; eight fractions of 4 Gy twice weekly) combined with HT. All 134 patients for whom such treatment was planned were included in the analysis. The complete response rate in 119 patients with macroscopic tumour was 71%. Including the 15 patients with microscopic disease, the local control rate was 73%. The median duration of local control was 32 months, and toxicity was acceptable. The complete response (CR) rate was higher, and the toxicity was less with the later developed 433-MHz HT technique compared with the 2450-MHz technique used initially. With this relatively well-tolerated treatment, palliation by local tumour control of a worthwhile duration is achieved in the majority of patients. The technique used for hyperthermia appeared to influence the achieved results. The value of HT in addition to this re-RT schedule has been confirmed by a prospective randomized trial in a similar patient group. In The Netherlands, this combined treatment is offered as standard to patients with breast cancer recurring in previously irradiated areas.  (+info)

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (4/14907)

The use of megestrol acetate in the treatment of weight loss in gastrointestinal cancer patients has been disappointing. The aim of the present study was to compare the combination of megestrol acetate and placebo with megestrol acetate and ibuprofen in the treatment of weight loss in such patients. At baseline, 4-6 weeks and 12 weeks, patients underwent measurements of anthropometry, concentrations of albumin and C-reactive protein and assessment of appetite, performance status and quality of life using EuroQol-EQ-5D and EORTC QLQ-C30. Thirty-eight and 35 patients (median weight loss 18%) were randomized to megestrol acetate/placebo or megestrol acetate/ibuprofen, respectively, for 12 weeks. Forty-six (63%) of patients failed to complete the 12-week assessment. Of those evaluable at 12 weeks, there was a decrease in weight (median 2.8 kg) in the megestrol acetate/placebo group compared with an increase (median 2.3 kg) in the megestrol acetate/ibuprofen group (P<0.001). There was also an improvement in the EuroQol-EQ-5D quality of life scores of the latter group (P<0.05). The combination of megestrol acetate/ibuprofen appeared to reverse weight loss and appeared to improve quality of life in patients with advanced gastrointestinal cancer. Further trials of this novel regimen in weight-losing patients with hormone-insensitive cancers are warranted.  (+info)

The minimum CD34 threshold depends on prior chemotherapy in autologous peripheral blood stem cell recipients. (5/14907)

We analysed 57 patients with non-myeloid malignancies who received a non-purged autologous PBSCT. All had similar mobilisation and conditioning regimens. A high prior chemotherapy score and the number of chemotherapy lines used (P = 0.015 and P = 0.01, respectively) were adverse predictors of CD34 cell yields. Lower CD34 values (P = 0.002) were seen in patients treated with potent stem cell toxins (BCNU, melphalan, CCNU and mustine), designated toxicity factor 4 agents (TF4). All patients infused with grafts containing CD34 cell doses between 1.0 and 2.0 x 10(6)/kg (range 1.25-1.90) engrafted by day 51. The only variable associated with slow platelet recovery was exposure to TF4 (P = 0.007). The majority of patients with CD34 >1.0 x 10(6)/kg achieved rapid and sustained engraftment and the only predictive factor of delayed recovery is prior exposure to stem cell toxins. Potential PBSCT candidates should if possible avoid first line and salvage chemotherapy containing TF4 drugs. We therefore advocate a minimum CD34 threshold of >1.0 x 10(6)/kg in patients without extensive prior chemoradiotherapy, and > or = 2.0 x 10(6)/kg in all other patients.  (+info)

Infectious complications in 126 patients treated with high-dose chemotherapy and autologous peripheral blood stem cell transplantation. (6/14907)

The effect of an extensive prophylactic antimicrobial regimen was prospectively assessed in 126 patients after high-dose chemotherapy and autologous PBSC. They received ciprofloxacin (500 mg/12 h), acyclovir (200 mg/6 h), and itraconazole (200 mg/12 h) orally until neutrophil recovery. Febrile patients received i.v. imipenem (500 mg/6 h) to which vancomycin and amikacin were added if fever persisted for 2-3 and 5 days, respectively. Amphotericin B lipid complex was further given on day 7 or 8 of fever. Median times for a neutrophil count of >0.5 x 10(9)/l and a platelet count of >20 x 10(9)/l were 9 and 11 days. Severe neutropenia (<0.1 x 10(9)/l) lasted for a median of 5 days in which 72% of febrile episodes and 50% of cases of bacteremia occurred. Gram-positive bacteria were isolated in 30 of 40 episodes of bacteremia, 25 of which were caused by Staphylococcus epidermidis. Clinical foci were the intravascular catheter in 35 cases, respiratory infection in 11, cellulitis in two, anal abscess in one, and neutropenic enterocolitis in one. The high incidence of febrile episodes (94%) and bacteremias (31%) may be due to the lack of efficacy of antimicrobial prophylaxis and the persistence of a 5-day period of severe neutropenia.  (+info)

Lymphomatoid granulomatosis following autologous stem cell transplantation. (7/14907)

Lymphomatoid granulomatosis (LYG) is a rare angio-destructive lymphoproliferative disorder (LPD) of uncertain etiology, with prominent pulmonary involvement. Recent studies indicate that LYG is an Epstein-Barr virus (EBV)-associated B cell LPD with large numbers of background reactive T lymphocytes (T cell-rich B cell lymphoma). Although the disease frequently, but not exclusively, occurs in various immunodeficiency states, it has not been reported in association with the transient immunosuppression following autologous bone marrow/peripheral stem cell transplantation (ABM/PSCT). We describe a patient who developed lymphomatoid granulomatosis of the lung approximately 2 weeks after high-dose chemotherapy and autologous peripheral stem cell transplantation for multiple myeloma. Although molecular studies showed no evidence of EBV genome in the biopsy material, the serologic profile with high IgM titers was suggestive of primary EBV infection. Complete radiologic remission occurred following reconstitution of the patient's immune response after a 2-week course of ganciclovir treatment. Despite the apparently low frequency of LPD (both LYG and EBV-associated post-transplant lymphoma) in the ABMT setting, we believe that it should be considered in the differential diagnosis of patients whose clinical course following ABMT is complicated by fevers, in the absence of an identifiable infectious process.  (+info)

Phase I study of eniluracil, a dihydropyrimidine dehydrogenase inactivator, and oral 5-fluorouracil with radiation therapy in patients with recurrent or advanced head and neck cancer. (8/14907)

5-Fluorouracil (5-FU) is an effective enhancer of radiation therapy (RT) in head and neck cancers. Due to rapid, predominantly hepatic metabolism by dihydropyrimidine dehydrogenase (DPD) and suggested clinical benefit from prolonged drug exposure, 5-FU is commonly given by continuous infusion. Eniluracil is a novel DPD-inactivator designed to prolong the half-life of 5-FU and provide sustained plasma concentrations of 5-FU with oral dosing. We conducted a Phase I study of the safety and efficacy of eniluracil given with oral 5-FU in patients receiving concurrent RT for recurrent or advanced squamous cell carcinomas of the head and neck. Thirteen patients with recurrent, metastatic, or high-risk (defined as an expected 2-year survival rate of <10%) head and neck cancer were enrolled and treated with concomitant chemoradiotherapy on an every-other-week schedule. Eniluracil at a fixed dose [20 mg twice a day (BID)] was given for 7 consecutive days (days 1-7). 5-FU and RT were given on 5 consecutive days (days 2-6). One patient was treated with once-daily RT (2.0 Gy fractions). The remaining patients received hyperfractionated RT (1.5-Gy fractions BID). The initial dose of 5-FU was 2.5 mg/m2 given BID. Dose escalation in patient cohorts was scheduled at 2.5-mg/m2 increments, with intrapatient dose escalation permitted. Lymphocyte DPD activity and serum 5-FU and uracil concentrations were monitored during two cycles. DPD activity was completely or nearly completely inactivated in all patients. Sustained, presumed therapeutic concentrations of 5-FU were observed at a dose of 5.0 mg/m2 given BID. Cumulative dose-limiting myelosuppression (both neutropenia and thrombocytopenia) was observed during the fourth and fifth cycles following administration of 5.0 mg/m2 5-FU BID. One patient died of neutropenic sepsis during cycle 4. Other late cycle toxicities included diarrhea, fatigue, and mucositis. Grade 3 mucositis was observed in 4 patients, but no grade 4 mucositis or grade 3 or 4 dermatitis was observed. A second patient death occurred during cycle 1 of treatment. No specific cause of death was identified. The study was subsequently discontinued. Cumulative myelosupression was the significant dose-limiting toxicity of oral 5-FU given with the DPD-inactivator eniluracil on an every-other-week schedule. Clinical radiation sensitization was not observed, based on the absence of dose-limiting mucositis and dermatitis. Alternative dosing schedules need to be examined to determine the most appropriate use of eniluracil and 5-FU as radiation enhancers.  (+info)

Combined modality therapy (CMT) is a medical treatment approach that utilizes more than one method or type of therapy simultaneously or in close succession, with the goal of enhancing the overall effectiveness of the treatment. In the context of cancer care, CMT often refers to the combination of two or more primary treatment modalities, such as surgery, radiation therapy, and systemic therapies (chemotherapy, immunotherapy, targeted therapy, etc.).

The rationale behind using combined modality therapy is that each treatment method can target cancer cells in different ways, potentially increasing the likelihood of eliminating all cancer cells and reducing the risk of recurrence. The specific combination and sequence of treatments will depend on various factors, including the type and stage of cancer, patient's overall health, and individual preferences.

For example, a common CMT approach for locally advanced rectal cancer may involve preoperative (neoadjuvant) chemoradiation therapy, followed by surgery to remove the tumor, and then postoperative (adjuvant) chemotherapy. This combined approach allows for the reduction of the tumor size before surgery, increases the likelihood of complete tumor removal, and targets any remaining microscopic cancer cells with systemic chemotherapy.

It is essential to consult with a multidisciplinary team of healthcare professionals to determine the most appropriate CMT plan for each individual patient, considering both the potential benefits and risks associated with each treatment method.

Mechlorethamine is an antineoplastic agent, which means it is used to treat cancer. It is a type of alkylating agent, which is a class of drugs that work by interfering with the DNA of cancer cells, preventing them from dividing and growing. Mechlorethamine is used in the treatment of Hodgkin's lymphoma and non-Hodgkin's lymphoma, as well as some other types of cancer. It can be administered intravenously or topically (as a cream) to treat skin lesions caused by certain types of cancer.

Mechlorethamine is a potent drug that can have significant side effects, including nausea, vomiting, hair loss, and an increased risk of infection due to suppression of the immune system. It can also cause damage to the heart, lungs, and reproductive system with long-term use. As with all chemotherapy drugs, mechlorethamine should be administered under the close supervision of a healthcare professional.

Procarbazine is an antineoplastic agent, specifically an alkylating agent, used in the treatment of certain types of cancer such as Hodgkin's lymphoma and brain tumors. It works by interfering with the DNA of cancer cells, preventing them from dividing and growing. Procarbazine is often used in combination with other chemotherapy drugs to increase its effectiveness.

It is important to note that procarbazine can have significant side effects, including nausea, vomiting, loss of appetite, and weakness. It can also suppress the immune system, increasing the risk of infection. Additionally, it can cause damage to cells outside of the cancerous tissue, which can result in side effects such as hair loss and mouth sores.

Procarbazine is a prescription medication that should only be used under the supervision of a healthcare professional. It is important for patients to follow their doctor's instructions carefully when taking this medication and to report any side effects or concerns promptly.

Hodgkin disease, also known as Hodgkin lymphoma, is a type of cancer that originates in the white blood cells called lymphocytes. It typically affects the lymphatic system, which is a network of vessels and glands spread throughout the body. The disease is characterized by the presence of a specific type of abnormal cell, known as a Reed-Sternberg cell, within the affected lymph nodes.

The symptoms of Hodgkin disease may include painless swelling of the lymph nodes in the neck, armpits, or groin; fever; night sweats; weight loss; and fatigue. The exact cause of Hodgkin disease is unknown, but it is thought to involve a combination of genetic, environmental, and infectious factors.

Hodgkin disease is typically treated with a combination of chemotherapy, radiation therapy, and/or immunotherapy, depending on the stage and extent of the disease. With appropriate treatment, the prognosis for Hodgkin disease is generally very good, with a high cure rate. However, long-term side effects of treatment may include an increased risk of secondary cancers and other health problems.

Lomustine is a medical term for a specific antineoplastic agent, which is a type of medication used to treat cancer. It's a nitrosourea compound that is classified as an alkylating agent, meaning it works by preventing the reproduction of cancer cells. Lomustine is used in the treatment of various types of cancer, including brain tumors, Hodgkin's lymphoma, and non-Hodgkin's lymphoma. It's usually administered orally in the form of a capsule. As with any medication, it can have side effects, which can include nausea, vomiting, and lowered blood cell counts.

Vincristine is an antineoplastic agent, specifically a vinca alkaloid. It is derived from the Madagascar periwinkle plant (Catharanthus roseus). Vincristine binds to tubulin, a protein found in microtubules, and inhibits their polymerization, which results in disruption of mitotic spindles leading to cell cycle arrest and apoptosis (programmed cell death). It is used in the treatment of various types of cancer including leukemias, lymphomas, and solid tumors. Common side effects include peripheral neuropathy, constipation, and alopecia.

Radiotherapy, also known as radiation therapy, is a medical treatment that uses ionizing radiation to kill cancer cells, shrink tumors, and prevent the growth and spread of cancer. The radiation can be delivered externally using machines or internally via radioactive substances placed in or near the tumor. Radiotherapy works by damaging the DNA of cancer cells, which prevents them from dividing and growing. Normal cells are also affected by radiation, but they have a greater ability to repair themselves compared to cancer cells. The goal of radiotherapy is to destroy as many cancer cells as possible while minimizing damage to healthy tissue.

Antineoplastic combined chemotherapy protocols refer to a treatment plan for cancer that involves the use of more than one antineoplastic (chemotherapy) drug given in a specific sequence and schedule. The combination of drugs is used because they may work better together to destroy cancer cells compared to using a single agent alone. This approach can also help to reduce the likelihood of cancer cells becoming resistant to the treatment.

The choice of drugs, dose, duration, and frequency are determined by various factors such as the type and stage of cancer, patient's overall health, and potential side effects. Combination chemotherapy protocols can be used in various settings, including as a primary treatment, adjuvant therapy (given after surgery or radiation to kill any remaining cancer cells), neoadjuvant therapy (given before surgery or radiation to shrink the tumor), or palliative care (to alleviate symptoms and prolong survival).

It is important to note that while combined chemotherapy protocols can be effective in treating certain types of cancer, they can also cause significant side effects, including nausea, vomiting, hair loss, fatigue, and an increased risk of infection. Therefore, patients undergoing such treatment should be closely monitored and managed by a healthcare team experienced in administering chemotherapy.

Radiotherapy dosage refers to the total amount of radiation energy that is absorbed by tissues or organs, typically measured in units of Gray (Gy), during a course of radiotherapy treatment. It is the product of the dose rate (the amount of radiation delivered per unit time) and the duration of treatment. The prescribed dosage for cancer treatments can range from a few Gray to more than 70 Gy, depending on the type and location of the tumor, the patient's overall health, and other factors. The goal of radiotherapy is to deliver a sufficient dosage to destroy the cancer cells while minimizing damage to surrounding healthy tissues.

Prednisone is a synthetic glucocorticoid, which is a type of corticosteroid hormone. It is primarily used to reduce inflammation in various conditions such as asthma, allergies, arthritis, and autoimmune disorders. Prednisone works by mimicking the effects of natural hormones produced by the adrenal glands, suppressing the immune system's response and reducing the release of substances that cause inflammation.

It is available in oral tablet form and is typically prescribed to be taken at specific times during the day, depending on the condition being treated. Common side effects of prednisone include increased appetite, weight gain, mood changes, insomnia, and easy bruising. Long-term use or high doses can lead to more serious side effects such as osteoporosis, diabetes, cataracts, and increased susceptibility to infections.

Healthcare providers closely monitor patients taking prednisone for extended periods to minimize the risk of adverse effects. It is essential to follow the prescribed dosage regimen and not discontinue the medication abruptly without medical supervision, as this can lead to withdrawal symptoms or a rebound of the underlying condition.

Actuarial analysis is a process used in the field of actuarial science to evaluate and manage risk, typically for financial or insurance purposes. It involves the use of statistical modeling, mathematical calculations, and data analysis to estimate the probability and potential financial impact of various events or outcomes.

In a medical context, actuarial analysis may be used to assess the risks and costs associated with different health conditions, treatments, or patient populations. For example, an actuary might use data on morbidity rates, mortality rates, and healthcare utilization patterns to estimate the expected costs of providing coverage to a group of patients with a particular medical condition.

Actuarial analysis can help healthcare organizations, insurers, and policymakers make informed decisions about resource allocation, pricing, and risk management. It can also be used to develop predictive models that identify high-risk populations or forecast future trends in healthcare utilization and costs.

Carcinoma, small cell is a type of lung cancer that typically starts in the bronchi (the airways that lead to the lungs). It is called "small cell" because the cancer cells are small and appear round or oval in shape. This type of lung cancer is also sometimes referred to as "oat cell carcinoma" due to the distinctive appearance of the cells, which can resemble oats when viewed under a microscope.

Small cell carcinoma is a particularly aggressive form of lung cancer that tends to spread quickly to other parts of the body. It is strongly associated with smoking and is less common than non-small cell lung cancer (NSCLC), which accounts for about 85% of all lung cancers.

Like other types of lung cancer, small cell carcinoma may not cause any symptoms in its early stages. However, as the tumor grows and spreads, it can cause a variety of symptoms, including coughing, chest pain, shortness of breath, hoarseness, and weight loss. Treatment for small cell carcinoma typically involves a combination of chemotherapy, radiation therapy, and sometimes surgery.

Lung neoplasms refer to abnormal growths or tumors in the lung tissue. These tumors can be benign (non-cancerous) or malignant (cancerous). Malignant lung neoplasms are further classified into two main types: small cell lung carcinoma and non-small cell lung carcinoma. Lung neoplasms can cause symptoms such as cough, chest pain, shortness of breath, and weight loss. They are often caused by smoking or exposure to secondhand smoke, but can also occur due to genetic factors, radiation exposure, and other environmental carcinogens. Early detection and treatment of lung neoplasms is crucial for improving outcomes and survival rates.

Adjuvant radiotherapy is a type of cancer treatment that uses radiation therapy as an adjunct to a primary surgical procedure. The goal of adjuvant radiotherapy is to eliminate any remaining microscopic cancer cells that may be present in the surrounding tissues after surgery, thereby reducing the risk of local recurrence and improving the chances of cure.

Radiotherapy involves the use of high-energy radiation to destroy cancer cells and shrink tumors. In adjuvant radiotherapy, the radiation is usually delivered to the tumor bed and regional lymph nodes in order to target any potential sites of residual disease. The timing and dosing of adjuvant radiotherapy may vary depending on the type and stage of cancer being treated, as well as other factors such as patient age and overall health status.

Adjuvant radiotherapy is commonly used in the treatment of various types of cancer, including breast, colorectal, lung, head and neck, and gynecologic cancers. Its use has been shown to improve survival rates and reduce the risk of recurrence in many cases, making it an important component of comprehensive cancer care.

Neoplasm staging is a systematic process used in medicine to describe the extent of spread of a cancer, including the size and location of the original (primary) tumor and whether it has metastasized (spread) to other parts of the body. The most widely accepted system for this purpose is the TNM classification system developed by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC).

In this system, T stands for tumor, and it describes the size and extent of the primary tumor. N stands for nodes, and it indicates whether the cancer has spread to nearby lymph nodes. M stands for metastasis, and it shows whether the cancer has spread to distant parts of the body.

Each letter is followed by a number that provides more details about the extent of the disease. For example, a T1N0M0 cancer means that the primary tumor is small and has not spread to nearby lymph nodes or distant sites. The higher the numbers, the more advanced the cancer.

Staging helps doctors determine the most appropriate treatment for each patient and estimate the patient's prognosis. It is an essential tool for communication among members of the healthcare team and for comparing outcomes of treatments in clinical trials.

Cyclophosphamide is an alkylating agent, which is a type of chemotherapy medication. It works by interfering with the DNA of cancer cells, preventing them from dividing and growing. This helps to stop the spread of cancer in the body. Cyclophosphamide is used to treat various types of cancer, including lymphoma, leukemia, multiple myeloma, and breast cancer. It can be given orally as a tablet or intravenously as an injection.

Cyclophosphamide can also have immunosuppressive effects, which means it can suppress the activity of the immune system. This makes it useful in treating certain autoimmune diseases, such as rheumatoid arthritis and lupus. However, this immunosuppression can also increase the risk of infections and other side effects.

Like all chemotherapy medications, cyclophosphamide can cause a range of side effects, including nausea, vomiting, hair loss, fatigue, and increased susceptibility to infections. It is important for patients receiving cyclophosphamide to be closely monitored by their healthcare team to manage these side effects and ensure the medication is working effectively.

Survival analysis is a branch of statistics that deals with the analysis of time to event data. It is used to estimate the time it takes for a certain event of interest to occur, such as death, disease recurrence, or treatment failure. The event of interest is called the "failure" event, and survival analysis estimates the probability of not experiencing the failure event until a certain point in time, also known as the "survival" probability.

Survival analysis can provide important information about the effectiveness of treatments, the prognosis of patients, and the identification of risk factors associated with the event of interest. It can handle censored data, which is common in medical research where some participants may drop out or be lost to follow-up before the event of interest occurs.

Survival analysis typically involves estimating the survival function, which describes the probability of surviving beyond a certain time point, as well as hazard functions, which describe the instantaneous rate of failure at a given time point. Other important concepts in survival analysis include median survival times, restricted mean survival times, and various statistical tests to compare survival curves between groups.

Doxorubicin is a type of chemotherapy medication known as an anthracycline. It works by interfering with the DNA in cancer cells, which prevents them from growing and multiplying. Doxorubicin is used to treat a wide variety of cancers, including leukemia, lymphoma, breast cancer, lung cancer, ovarian cancer, and many others. It may be given alone or in combination with other chemotherapy drugs.

Doxorubicin is usually administered through a vein (intravenously) and can cause side effects such as nausea, vomiting, hair loss, mouth sores, and increased risk of infection. It can also cause damage to the heart muscle, which can lead to heart failure in some cases. For this reason, doctors may monitor patients' heart function closely while they are receiving doxorubicin treatment.

It is important for patients to discuss the potential risks and benefits of doxorubicin therapy with their healthcare provider before starting treatment.

Prognosis is a medical term that refers to the prediction of the likely outcome or course of a disease, including the chances of recovery or recurrence, based on the patient's symptoms, medical history, physical examination, and diagnostic tests. It is an important aspect of clinical decision-making and patient communication, as it helps doctors and patients make informed decisions about treatment options, set realistic expectations, and plan for future care.

Prognosis can be expressed in various ways, such as percentages, categories (e.g., good, fair, poor), or survival rates, depending on the nature of the disease and the available evidence. However, it is important to note that prognosis is not an exact science and may vary depending on individual factors, such as age, overall health status, and response to treatment. Therefore, it should be used as a guide rather than a definitive forecast.

Cisplatin is a chemotherapeutic agent used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. It is an inorganic platinum compound that contains a central platinum atom surrounded by two chloride atoms and two ammonia molecules in a cis configuration.

Cisplatin works by forming crosslinks between DNA strands, which disrupts the structure of DNA and prevents cancer cells from replicating. This ultimately leads to cell death and slows down or stops the growth of tumors. However, cisplatin can also cause damage to normal cells, leading to side effects such as nausea, vomiting, hearing loss, and kidney damage. Therefore, it is essential to monitor patients closely during treatment and manage any adverse effects promptly.

Adjuvant chemotherapy is a medical treatment that is given in addition to the primary therapy, such as surgery or radiation, to increase the chances of a cure or to reduce the risk of recurrence in patients with cancer. It involves the use of chemicals (chemotherapeutic agents) to destroy any remaining cancer cells that may not have been removed by the primary treatment. This type of chemotherapy is typically given after the main treatment has been completed, and its goal is to kill any residual cancer cells that may be present in the body and reduce the risk of the cancer coming back. The specific drugs used and the duration of treatment will depend on the type and stage of cancer being treated.

Treatment outcome is a term used to describe the result or effect of medical treatment on a patient's health status. It can be measured in various ways, such as through symptoms improvement, disease remission, reduced disability, improved quality of life, or survival rates. The treatment outcome helps healthcare providers evaluate the effectiveness of a particular treatment plan and make informed decisions about future care. It is also used in clinical research to compare the efficacy of different treatments and improve patient care.

Clinical trials are research studies that involve human participants and are designed to evaluate the safety and efficacy of new medical treatments, drugs, devices, or behavioral interventions. The purpose of clinical trials is to determine whether a new intervention is safe, effective, and beneficial for patients, as well as to compare it with currently available treatments. Clinical trials follow a series of phases, each with specific goals and criteria, before a new intervention can be approved by regulatory authorities for widespread use.

Clinical trials are conducted according to a protocol, which is a detailed plan that outlines the study's objectives, design, methodology, statistical analysis, and ethical considerations. The protocol is developed and reviewed by a team of medical experts, statisticians, and ethicists, and it must be approved by an institutional review board (IRB) before the trial can begin.

Participation in clinical trials is voluntary, and participants must provide informed consent before enrolling in the study. Informed consent involves providing potential participants with detailed information about the study's purpose, procedures, risks, benefits, and alternatives, as well as their rights as research subjects. Participants can withdraw from the study at any time without penalty or loss of benefits to which they are entitled.

Clinical trials are essential for advancing medical knowledge and improving patient care. They help researchers identify new treatments, diagnostic tools, and prevention strategies that can benefit patients and improve public health. However, clinical trials also pose potential risks to participants, including adverse effects from experimental interventions, time commitment, and inconvenience. Therefore, it is important for researchers to carefully design and conduct clinical trials to minimize risks and ensure that the benefits outweigh the risks.

Medical survival rate is a statistical measure used to determine the percentage of patients who are still alive for a specific period of time after their diagnosis or treatment for a certain condition or disease. It is often expressed as a five-year survival rate, which refers to the proportion of people who are alive five years after their diagnosis. Survival rates can be affected by many factors, including the stage of the disease at diagnosis, the patient's age and overall health, the effectiveness of treatment, and other health conditions that the patient may have. It is important to note that survival rates are statistical estimates and do not necessarily predict an individual patient's prognosis.

Adenocarcinoma is a type of cancer that arises from glandular epithelial cells. These cells line the inside of many internal organs, including the breasts, prostate, colon, and lungs. Adenocarcinomas can occur in any of these organs, as well as in other locations where glands are present.

The term "adenocarcinoma" is used to describe a cancer that has features of glandular tissue, such as mucus-secreting cells or cells that produce hormones. These cancers often form glandular structures within the tumor mass and may produce mucus or other substances.

Adenocarcinomas are typically slow-growing and tend to spread (metastasize) to other parts of the body through the lymphatic system or bloodstream. They can be treated with surgery, radiation therapy, chemotherapy, targeted therapy, or a combination of these treatments. The prognosis for adenocarcinoma depends on several factors, including the location and stage of the cancer, as well as the patient's overall health and age.

Disease-free survival (DFS) is a term used in medical research and clinical practice, particularly in the field of oncology. It refers to the length of time after primary treatment for a cancer during which no evidence of the disease can be found. This means that the patient shows no signs or symptoms of the cancer, and any imaging studies or other tests do not reveal any tumors or other indications of the disease.

DFS is often used as an important endpoint in clinical trials to evaluate the effectiveness of different treatments for cancer. By measuring the length of time until the cancer recurs or a new cancer develops, researchers can get a better sense of how well a particular treatment is working and whether it is improving patient outcomes.

It's important to note that DFS is not the same as overall survival (OS), which refers to the length of time from primary treatment until death from any cause. While DFS can provide valuable information about the effectiveness of cancer treatments, it does not necessarily reflect the impact of those treatments on patients' overall survival.

Fluorouracil is a antineoplastic medication, which means it is used to treat cancer. It is a type of chemotherapy drug known as an antimetabolite. Fluorouracil works by interfering with the growth of cancer cells and ultimately killing them. It is often used to treat colon, esophageal, stomach, and breast cancers, as well as skin conditions such as actinic keratosis and superficial basal cell carcinoma. Fluorouracil may be given by injection or applied directly to the skin in the form of a cream.

It is important to note that fluorouracil can have serious side effects, including suppression of bone marrow function, mouth sores, stomach and intestinal ulcers, and nerve damage. It should only be used under the close supervision of a healthcare professional.

Carcinoma, non-small-cell lung (NSCLC) is a type of lung cancer that includes several subtypes of malignant tumors arising from the epithelial cells of the lung. These subtypes are classified based on the appearance of the cancer cells under a microscope and include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. NSCLC accounts for about 85% of all lung cancers and tends to grow and spread more slowly than small-cell lung cancer (SCLC).

NSCLC is often asymptomatic in its early stages, but as the tumor grows, symptoms such as coughing, chest pain, shortness of breath, hoarseness, and weight loss may develop. Treatment options for NSCLC depend on the stage and location of the cancer, as well as the patient's overall health and lung function. Common treatments include surgery, radiation therapy, chemotherapy, targeted therapy, or a combination of these approaches.

Follow-up studies are a type of longitudinal research that involve repeated observations or measurements of the same variables over a period of time, in order to understand their long-term effects or outcomes. In medical context, follow-up studies are often used to evaluate the safety and efficacy of medical treatments, interventions, or procedures.

In a typical follow-up study, a group of individuals (called a cohort) who have received a particular treatment or intervention are identified and then followed over time through periodic assessments or data collection. The data collected may include information on clinical outcomes, adverse events, changes in symptoms or functional status, and other relevant measures.

The results of follow-up studies can provide important insights into the long-term benefits and risks of medical interventions, as well as help to identify factors that may influence treatment effectiveness or patient outcomes. However, it is important to note that follow-up studies can be subject to various biases and limitations, such as loss to follow-up, recall bias, and changes in clinical practice over time, which must be carefully considered when interpreting the results.

Diagnostic imaging is a medical specialty that uses various technologies to produce visual representations of the internal structures and functioning of the body. These images are used to diagnose injury, disease, or other abnormalities and to monitor the effectiveness of treatment. Common modalities of diagnostic imaging include:

1. Radiography (X-ray): Uses ionizing radiation to produce detailed images of bones, teeth, and some organs.
2. Computed Tomography (CT) Scan: Combines X-ray technology with computer processing to create cross-sectional images of the body.
3. Magnetic Resonance Imaging (MRI): Uses a strong magnetic field and radio waves to generate detailed images of soft tissues, organs, and bones.
4. Ultrasound: Employs high-frequency sound waves to produce real-time images of internal structures, often used for obstetrics and gynecology.
5. Nuclear Medicine: Involves the administration of radioactive tracers to assess organ function or detect abnormalities within the body.
6. Positron Emission Tomography (PET) Scan: Uses a small amount of radioactive material to produce detailed images of metabolic activity in the body, often used for cancer detection and monitoring treatment response.
7. Fluoroscopy: Utilizes continuous X-ray imaging to observe moving structures or processes within the body, such as swallowing studies or angiography.

Diagnostic imaging plays a crucial role in modern medicine, allowing healthcare providers to make informed decisions about patient care and treatment plans.

Medical Definition:

Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic imaging technique that uses a strong magnetic field and radio waves to create detailed cross-sectional or three-dimensional images of the internal structures of the body. The patient lies within a large, cylindrical magnet, and the scanner detects changes in the direction of the magnetic field caused by protons in the body. These changes are then converted into detailed images that help medical professionals to diagnose and monitor various medical conditions, such as tumors, injuries, or diseases affecting the brain, spinal cord, heart, blood vessels, joints, and other internal organs. MRI does not use radiation like computed tomography (CT) scans.

X-ray computed tomography (CT or CAT scan) is a medical imaging method that uses computer-processed combinations of many X-ray images taken from different angles to produce cross-sectional (tomographic) images (virtual "slices") of the body. These cross-sectional images can then be used to display detailed internal views of organs, bones, and soft tissues in the body.

The term "computed tomography" is used instead of "CT scan" or "CAT scan" because the machines take a series of X-ray measurements from different angles around the body and then use a computer to process these data to create detailed images of internal structures within the body.

CT scanning is a noninvasive, painless medical test that helps physicians diagnose and treat medical conditions. CT imaging provides detailed information about many types of tissue including lung, bone, soft tissue and blood vessels. CT examinations can be performed on every part of the body for a variety of reasons including diagnosis, surgical planning, and monitoring of therapeutic responses.

In computed tomography (CT), an X-ray source and detector rotate around the patient, measuring the X-ray attenuation at many different angles. A computer uses this data to construct a cross-sectional image by the process of reconstruction. This technique is called "tomography". The term "computed" refers to the use of a computer to reconstruct the images.

CT has become an important tool in medical imaging and diagnosis, allowing radiologists and other physicians to view detailed internal images of the body. It can help identify many different medical conditions including cancer, heart disease, lung nodules, liver tumors, and internal injuries from trauma. CT is also commonly used for guiding biopsies and other minimally invasive procedures.

In summary, X-ray computed tomography (CT or CAT scan) is a medical imaging technique that uses computer-processed combinations of many X-ray images taken from different angles to produce cross-sectional images of the body. It provides detailed internal views of organs, bones, and soft tissues in the body, allowing physicians to diagnose and treat medical conditions.

Combined Modality Therapy of Central Nervous System Tumors. ISBN 9783540006275. Hoh DJ, Liu CY, Pagnini PG, Yu C, Wang MY, ... Chained lightning: part III--Emerging technology, novel therapeutic strategies, and new energy modalities for radiosurgery. ... technology transfer and the implementation of advanced technologies to the therapy of brain diseases. In 1991, he was appointed ...
... the modalities can be combined; antibody-drug conjugates combine biologic and cytotoxic mechanisms into one targeted therapy. ... Targeted therapy or molecularly targeted therapy is one of the major modalities of medical treatment (pharmacotherapy) for ... the term biologic therapy is sometimes synonymous with targeted therapy when used in the context of cancer therapy (and thus ... Targeted therapy Targeted drug delivery Targeted molecular therapy for neuroblastoma Targeted therapy of lung cancer Treatment ...
"Manual Lymph Drainage Combined With Compression Therapy for Arm Lymph- edema Following Breast Cancer Treatment" (PDF). Swedish ... Milady's Guide to Lymph Drainage Massage; Ramona Moody French; Delmar/Cengage; 2004 Stillerman, Elaine (2009). Modalities for ... Explanation of Manual lymphedema therapy on National Cancer Institute. (Articles with short description, Short description ... they returned to Copenhagen to teach other practitioners to use this therapy. ...
"Intracranial choriocarcinoma causing precocious puberty and cured with combined modality therapy". Journal of Paediatrics and ...
Mira, J.G.: Combined Modality Treatment for Small Cell Lung Cancer. Chapter in Combined Chemotherapy and Radiotherapy in ... He was elected Head of the Radiotherapy department of the Cancer Therapy & Research Center every year between 1993 and 2007. He ... He was named Director of Radiotherapy in the Cancer Therapy & Research Center, under the National Cancer Institute, where he ... McCracken, J.D. and Mira, J.G.: Concurrent Chemotherapy and Radiation Therapy for Limited Small Cell Lung Cancer. Monograph, ...
December 1983). "Intensive combined modality therapy including low-dose TBI in high-risk Ewing's Sarcoma Patients". Int. J. ... August 2003). "High-dose therapy for patients with primary multifocal and early relapsed Ewing's tumors: results of two ... total body irradiation has been explored as a treatment modality for high-risk Ewing sarcoma. However, subsequent findings ...
... will play a decisive role for ongoing intensified combined modality treatments for GI cancers. The following ... Particle therapy Charged particle therapy Hadron Microbeam Fast neutron therapy Boron neutron capture therapy Linear energy ... Proton Beam Therapy Proton therapy - MedlinePlus Medical Encyclopedia Proton Therapy What is Proton Therapy (Pages with non- ... Because scattering therapy was the first type of proton therapy available, most clinical data available on proton therapy- ...
Most commonly, an estrogen is combined with an antiandrogen to suppress and block testosterone. This allows for ... Estrogens are administered in various modalities including injection, transdermal patch, and oral tablets. The desired effects ... Transgender hormone therapy, also called hormone replacement therapy (HRT) or gender-affirming hormone therapy (GAHT), is a ... and hormone therapy ("HRT" or gender-affirming hormone therapy) may be a part of that. Some transgender people choose to self- ...
... is therefore often combined with other modalities such as in-person therapy. Important areas of ... Types of therapy available include motor training exercises, speech therapy, virtual reality, robotic therapy, goal setting, ... robotic therapy, community-therapy. Motor strengthening exercises are the most commonly implemented modality. In motor training ... Robotic therapy has even been combined with virtual reality telerehabilitation to create a virtual environment which responds ...
Haddock MG1, Miller RC, Nelson H. Combined modality therapy including intraoperative electron irradiation for locally recurrent ... Radiation Therapy Intraoperative Radiation Therapy (Proceedings of the Third International Symposium on Intraoperative) edited ... Abe M. History of Intraoperative radiation therapy. In:Debelbower RR, Abe M (eds) Intraoperative radiation therapy. CRC, Boca ... Frontiers of Radiation Therapy and Oncology vol 31. Editor(s): Vaeth, J.M. (Mill Valley, Calif.). New techniques in electron ...
It is also used in feminizing hormone therapy for transgender women. PEP is a form of high-dose estrogen therapy. After an ... PEP has been compared to combined androgen blockade (CAB; castration plus flutamide) for the treatment of prostate cancer in a ... At 18.5 months, there was no difference in survival or cardiovascular toxicity between the two treatment modalities. These ... Oral estrogen therapy is as effective as orchiectomy in terms of cancer inhibitory effect, but its acceptance as primary ...
The therapy normally lasts for 5 minutes and is repeated at least 4 times a day. Full treatment programs typically contain a ... The treatment modality of patterning was developed in the 1960s by Glenn Doman and Carl Delacato. The Institutes for the ... range of exercises combined with sensory stimulation, breathing exercises designed to increase oxygen flow to the brain, and ... and treatment primarily focuses on non-invasive physical therapy in each of the stages. In one such stage, the homolateral ...
It is possible that the two modalities have a synergistic effect and patients may benefit from combined treatment. Prior to the ... An animal tumor model demonstrated improved survival after combined treatment with RFA and radiation therapy compared to either ... Reduced tumor growth with combined radiofrequency ablation and radiation therapy in a rat breast tumor model. Radiology 2005. ... July 2006). "Percutaneous Image-guided Thermal Ablation and Radiation Therapy: Outcomes of Combined Treatment for 41 Patients ...
These therapy modalities are focused on empowering individuals to reduce stress levels and elicit a relaxation response in ... Holistic nursing combines standard nursing interventions with various modalities that are focused on treating the patient in ... Alternative therapies can include stress management, aroma therapy, and therapeutic touch. The combination of interventions ... Several of the therapies included in holistic nursing rely on therapeutic environments to be successful and effective. A ...
... hormone therapy, immunotherapy and combined treatment modalities such as chemo-radiotherapy. Starting in the mid-1990s, the ... How treatments can best be combined (in combination therapies) Research into the cause of cancer involves many different ... as potential bifunctional cancer vaccines Newer forms of chemotherapy Gene therapy Photodynamic therapy Radiation therapy ... Radiation therapy took hold in the 1900s. Chemotherapeutics were developed and refined throughout the 20th century. The U.S. ...
Others use a "triple modality" combination of external beam radiation therapy, brachytherapy, and hormonal therapy. In advanced ... when surgery or radiation therapy alone is less likely to cure the cancer. Some radiation oncologists combine external beam ... and photodynamic therapy that permit focal therapy by utilizing image guidance. These therapies are still in beginning or ... and external-beam radiation therapy, proton therapy, high-intensity focused ultrasound (HIFU), cryosurgery, hormonal therapy, ...
The best overall survival rates are seen after combined radiation therapy combined with chemotherapy (5-FU + Mitomycin) in ... This "combined modality" approach has led to the increased preservation of an intact anal sphincter, and therefore improved ... Current gold-standard therapy is the combination of chemotherapy and radiation treatment to reduce the necessity of ... Standard treatment may include radiation therapy, chemotherapy, and surgery. About 8,300 people are diagnosed a year in the ...
... and combined modality therapy such as radiotherapy with surgery, chemotherapy, or immunotherapy. To provide the treatment ... Radiation can be given as a curative modality, either alone or in combination with surgery and/or chemotherapy. It may also be ... In Iran, radiation oncologists, who are trained in non-surgical aspects of oncology (including radiation therapy) directly ... "What to Expect When Having Radiation Therapy". Cancer.Net. 2013-03-22. Retrieved 2020-10-01. (Articles with short description, ...
... combined modality therapies, altered fractionation, cost-effectiveness, and outcomes research. He has run numerous ... Combined modality treatment of tumors of the CNS and thorax, as well as pediatric neoplasms: integrating systemic chemotherapy ... Effects of therapies on cognition and developing methods to improve neurocognitive function. Medical director, the Maryland ... Chair, Brain Tumor Committee, Radiation Therapy Oncology Group. Dr. Mehta's son, Tej Mehta, is currently a Captain in the ...
These two modalities affect not only the cancer affected cells, but also the normal cells Now in AIET, specific types of cells ... has proven that the cell based immunotherapy when combined with conventional treatment the efficacy improves by 20-30%. A ... This is the mechanism by which AIET is effective in cancer therapy. Adoptive Immuno cell therapy of cancer was first introduced ... Autologous immune enhancement therapy (AIET) is a treatment method in which immune cells are taken out from the patient's body ...
... chemoradiation strategies for combined modality therapy, and patient selection criteria. In 2009, she was the recipient of the ... Mitchell conducted and published clinical evidence of the merits of combined-modality treatment. In August 2015, Mitchell was ... With a team of researchers in the NRG Oncology/Radiation Therapy Oncology Group (RTOG), ...
... optionally combine art-making with basic psychotherapeutic modalities in their treatment. Therapists may better understand a ... Art therapy (not to be confused with arts therapy, which includes other creative therapies such as drama therapy and music ... Other forms of therapy that tends to help individuals with autism is play therapy and ABA Therapy. Often times feelings tend to ... The last way art therapy is looked at is through the lens of art as therapy. Some art therapists practicing art as therapy ...
Ultrasound therapy: First introduced as a treatment modality in 1992, it involves the application of high-frequency sound waves ... Multidisciplinary approach (HBO + Surgery): Studies have shown support of combining HBO therapy and a surgical approach to ... while combined with debridement. Hyperbaric oxygen therapy (HBO): First described in 1973, HBO was intended to be an adjunctive ... which is likely attributable to improvements in radiation therapy. Radiation therapy destroys cancer primarily by causing DNA ...
A combined therapeutic approach which is at least twice as effective as other therapeutic modalities published to date is ... Jackson JL, O'Malley PG, Kroenke K (March 2006). "Antidepressants and cognitive-behavioral therapy for symptom syndromes". CNS ... Steele RE, de Leeuw E, Carpenter D. "A novel and effective treatment modality for medically unexplained symptoms" J Pain ... "A novel and effective treatment modality for medically unexplained symptoms". The next best documented approach is cognitive ...
Occupational therapy Physical therapy Speech and language pathology Brunnstrom Approach Frenkel exercises Lennon, S; Ashburn, A ... Therapeutic handling is a method applied to influence movement quality, combining both facilitation and inhibition approaches. ... The precise application of facilitation during motor tasks involves considerations of timing, modality, intensity, and ... A highly significant 2021 "position paper" by the Academy of Neurologic Physical Therapy of the American Physical Therapy ...
It is clear that strategically integrating immune-based therapies with standard cancer treatment modalities, in particular ... Chemoimmunotherapy is chemotherapy combined with immunotherapy. Chemotherapy uses different drugs to kill or slow the growth of ... whereas systemic therapies (chemotherapy, endocrine therapy, molecularly targeted therapies, and adjunctive therapies ( ... Combination of different therapies in cancer has become a trend, not just between different types of therapies, also multiple ...
This includes the modalities dance therapy, drama therapy, art therapy, music therapy, writing therapy, among others. This may ... meseron therapy and systemic therapies based on the Ubuntu philosophy. Integrative psychotherapy is an attempt to combine ideas ... multimodal therapy, and therapies for specific disorders including PTSD therapies such as cognitive processing therapy and EMDR ... Psychotherapy (also psychological therapy, talk therapy, or talking therapy) is the use of psychological methods, particularly ...
Radiation therapy combined with partial surgical resection or radiation therapy alone have been used in cases where the primary ... therapy and chemotherapy to treat LGFMS are limited and this tumor does not appear very sensitive to either treatment modality ...
Palliative treatment consists of radiation therapy usually combined with chemotherapy. The use of tracheostomy as part of ... and if combined modality treatment is used. Treatment of anaplastic thyroid cancer is generally palliative in its intent due to ... Combinatorial therapy that is molecular-based may lead to significant tumor regression, potentially making patients amenable to ... Recent advances show that using a combination of novel targeted therapies, immunotherapy, and surgery, 1 year and 2 year ...
Combined modality therapy is the most common approach for the initial treatment of thyroid lymphomas. The CHOP regimen ( ... However, it is suggested to perform radiation therapy only for MALT resulting a 96% complete response, with only a 30% relapse ...
Role of Radiaton Therapy in the Combined-Modality Treatment of Patients with Extensive Disease Small-Cell Lung Cancer: A ... Role of Radiaton Therapy in the Combined-Modality Treatment of Patients with Extensive Disease Small-Cell Lung Cancer: A ... Accelerated hyperfractionated radiation therapy (AHFRT) to the thorax with concurrent carboplatin and etoposide (CE) ... 6 cycles.3 The benefits of thoracic radiation therapy (TRT) have been demonstrated in numerous randomized trials for limited ...
Long-term outcomes of selective bladder preservation by combined-modality therapy for invasive bladder cancer: The MGH ... Whether organ-conserving treatment by combined-modality therapy (CMT) achieves comparable long-term survival to radical ... Seventy-two percent of patients (78% with stage T2) had CR to induction therapy. Five-, 10-, and 15-yr DSS rates were 64%, 59 ... Repeat biopsy was performed after 40Gy, with initial tumor response guiding subsequent therapy. Those patients showing complete ...
"Combined Modality Therapy" by people in this website by year, and whether "Combined Modality Therapy" was a major or minor ... "Combined Modality Therapy" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Combined Modality Therapy" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Combined Modality Therapy". ...
Neoadjuvant Chemoradiation Therapy. The M. D. Anderson group,[12] and for an even longer time the group from the Fox-Chase ... Commentary (Sarr/Farnell): Combined-Modality Treatment for Operable Pancreatic Adenocarcinoma. Mar 1, 2005. Michael G. Sarr, MD ... However, others raise arguments against the concept of neoadjuvant therapy for pancreatic cancer that are not as well-discussed ... Total costs increase with upfront, preresection chemoradiation therapy. Most of these patients also need some form of biliary ...
Combined modality therapy of gastrointestinal tract cancer / P. Schlag, P. Hohenberger, U. Metzger (eds.) Contributor(s): ... WI 149 88CO Combined modality therapy of gastrointestinal tract cancer / WI 15 72TH-1 Types histologiques des tumeurs des ... Combined modality therapyNLM classification: WI 149 Tags from this library: No tags from this library for this title. Log in to ...
Combined Modality Therapy * Drug Administration Schedule * Female * Humans * Infusions, Intravenous * Infusions, Parenteral ... Antineoplastic Combined Chemotherapy Protocols / administration & dosage* * Antineoplastic Combined Chemotherapy Protocols / ... and neurologic toxic effects were more common in the intraperitoneal-therapy group than in the intravenous-therapy group (P, or ... 0.001). Only 42 percent of the patients in the intraperitoneal-therapy group completed six cycles of the assigned therapy, but ...
Appraisal-Based Cognitive-Behavior Therapy. A-CBT consisted of ERP combined with cognitive interventions focused on correcting ... We hypothesized that all three treatment modalities would be effective in reducing symptom severity, but that I-CBT would be ... Obsessive-compulsive disorder, Cognitive-behavioral therapy, Inference-based approach, Mindfulness, Randomized controlled trial ... Mindfulness-Based Cognitive Therapy for Patients with Medically Unexplained Symptoms: A Randomized Controlled Trial Psychother ...
Combined modality treatment of keloids. One of the most commonly used combination therapies employs cold-knife excision ... and combined modality treatment. Many published reports advocate a variety of therapies; however, few studies provide a ... Interferon (IFN) therapy is used because of its ability to reduce collagen synthesis in dermal fibroblasts. Granstein et al ... A second method of radiation therapy involves the use of interstitial iridium 192 high-dose-rate brachytherapy. [16, 17] Some ...
Non-Small Cell Lung Cancer (Combined Modality Therapy). LULACATRT. Treatment of Locally Advanced Non-Small Cell Lung Cancer ... A new combination therapy shows promise for treatment-resistant blood cancers. *Pap Awareness Month 2018 - Cervix Screening ... Targeted Therapy. LUAVAFAT. First-Line Treatment of Epidermal Growth Factor Receptor (EGFR) Mutation-Positive Advanced Non- ... Maintenance Therapy of Advanced Non-Small Cell Lung Cancer (NSCLC) with Erlotinib After First-Line Chemotherapy ...
Combined Modality Therapy * Female * Humans * Male * Middle Aged * Multivariate Analysis * Prognosis * Radiation Injuries ... Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: ... Patients with one to three newly diagnosed brain metastases were randomly allocated either whole brain radiation therapy (WBRT ... radiosurgery provided any therapeutic benefit in a randomised multi-institutional trial directed by the Radiation Therapy ...
The majority of the patients had combined cisplatin-based chemoradiation. The isocenter was not used consistently as a dose ... Antineoplastic Combined Chemotherapy Protocols, *Canada, *Cancer Care Facilities, *Combined Modality Therapy, *Esophageal ... The majority of the patients had combined cisplatin-based chemoradiation. The isocenter was not used consistently as a dose ...
Combined modality doxorubicin-based chemotherapy and chitosan-mediated p53 gene therapy using double-walled microspheres for ... Combined modality doxorubicin-based chemotherapy and chitosan-mediated p53 gene therapy using double-walled microspheres for ... Combined modality doxorubicin-based chemotherapy and chitosan-mediated p53 gene therapy using double-walled microspheres for ... T1 - Combined modality doxorubicin-based chemotherapy and chitosan-mediated p53 gene therapy using double-walled microspheres ...
Combined Modality Therapy of Central Nervous System Tumors. ISBN 9783540006275. Hoh DJ, Liu CY, Pagnini PG, Yu C, Wang MY, ... Chained lightning: part III--Emerging technology, novel therapeutic strategies, and new energy modalities for radiosurgery. ... technology transfer and the implementation of advanced technologies to the therapy of brain diseases. In 1991, he was appointed ...
She was treated with combined modality therapy. * A 55-year-old female with tongue burning for 15 months. The history for ... 68] Attempting combinations of therapies may be appropriate; in particular, cognitive therapy may be synergistic with other ... There is some emerging data to support the use of laser therapy. For example, a literature review by Al-Maweri et al found that ... A burning therapy for burning mouth syndrome: preliminary results with the administration of topical capsaicin. J Biol Regul ...
Each treatment modality lasted 1 year. Pharmacotherapists were free to choose between 5 SSRIs currently marketed in The ... A Randomized Trial of Cognitive-Behavioral Therapy or Selective Serotonin Reuptake Inhibitor or Both Combined for Panic ... Conclusions: No fall-off in gains was observed for either treatment modality after treatment discontinuation. SSRIs were ... cognitive-behavioral therapy (CBT), pharmacotherapy using a selective serotonin reuptake inhibitor (SSRI), or the combination ...
... laser therapy, targeted therapy, and palliative care. Get detailed treatment information for newly diagnosed and recurrent ... Chemotherapy and radiation therapy. Combined-modality treatment with etoposide and cisplatin with thoracic radiation therapy ( ... Systematic review evaluating the timing of thoracic radiation therapy in combined modality therapy for limited-stage small-cell ... Improved long-term survival in patients with LD has been shown with combined-modality therapy.[24,26][Level of evidence A1] ...
Ultrasmall biocompatible WO3−x nanodots for multi‐modality imaging and combined therapy of cancers. Adv. Mater. 28, 5072-5079 ( ...
Carcinoma/drug therapy; Chemotherapy, Cancer, Regional Perfusion; Colorectal Neoplasms/drug therapy; Combined Modality Therapy ... Colorectal Neoplasms/drug therapy, Combined Modality Therapy, Disease-Free Survival, Female, Humans, Hyperthermia, Induced, ... Local/drug therapy; Perioperative Care; Peritoneal Neoplasms/drug therapy}}, language = {{eng}}, number = {{4}}, pages = {{864 ... Adult, Aged, Carcinoma/drug therapy, Chemotherapy, Cancer, Regional Perfusion, ...
Combined modality therapies (1) Journal. Filter by journal. * Clinical Cancer Research (4) ... Combined 1p/19q Loss in Oligodendroglial Tumors: Predictive or Prognostic Biomarker? The German Glioma Network, Michael Weller ... Open the PDF for Combined 1p/19q Loss in Oligodendroglial Tumors: Predictive or Prognostic Biomarker? in another window ... View article titled, Combined 1p/19q Loss in Oligodendroglial Tumors: Predictive or Prognostic Biomarker? ...
Combining negative pressure wound therapy with other wound management modalities. Ostomy Wound Manage. 2005 Feb. 51 (2A Suppl): ... Daily whirlpool therapy or pulse lavage therapy may be used to irrigate and mechanically debride the wound. ... Therefore, when antibiotic therapy is ordered, the wound care specialist must be alert to detect signs of antibiotic resistance ... Clinitron therapy and the decubitus ulcer: preliminary dermatologic studies. Int J Dermatol. 1980 Nov. 19(9):517-8. [QxMD ...
This combined modality treatment is considered the standard of care. According to the TMZ (Temodar®, Temodal®) package insert ... Gliadel has been approved for GBM after surgical resection, based on trials performed before TMZ therapy was established7. The ... 9. Any other cytotoxic or biologic anti-tumor therapy received prior to enrollment will be. considered exclusion.. 10. Admitted ... EF-32 (TRIDENT): A Pivotal Randomized, Open-Label Study of Optune® (TTFields, 200khz) Concomitant with Radiation Therapy and ...
The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic ... However, despite having the promising outcome of preclinical studies, the clinical application of stem cell therapy remained ... therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative ... Recently, a growing number of studies are focusing on mesenchymal stem cell-based therapies for neurodegenerative disorders. ...
I take an integrative approach combining person-centered, CBT, body work, and psychodynamic modalities. ... TherapistsOnline TherapyPsychiatristsTreatment CentersSupport Groups More. TherapistsOnline TherapyPsychiatristsTreatment ... Therapy can be an enriching and rewarding process. It is my hope to support you and help deepen your understanding of your ...
COMBINING TREATMENT MODALITIES TO OPTIMIZE RESULTS. Comprehensive treatment through the initial and recare administration of ... CHOOSING THERAPIES FOR THE BEST QUALITY TREATMENT. The dilemma that we all face is deciding which pathways and modalities to ... In many of the situations discussed here, combined clinical care may involve a variety of supportive modalities to treat the ... Sequential Therapy. Sequential therapy is performed when more advanced pocketing is observed. For example, a patient presents ...
Combined-modality therapy:. * Consider primary combined radiotherapy and chemotherapy for locally advanced, unresectable ... Neoadjuvant radiation therapy as well as combined chemoradiation therapy have also been effective at allowing later surgeries. ... When indicated, surgery may followed by RAI therapy. Thyroxine therapy is mandatory for patients undergoing total thyroidectomy ... Therapy for unresectable or recurrent disease or for metastases is as follows [20] :. * Radiotherapy may be considered for ...
combined modality therapy (2) * cytokine (2) * insulin (2) * islets of langerhans transplantation (2) ... Combination Therapy With Sirolimus and Interleukin-2 Prevents Spontaneous and Recurrent Autoimmune Diabetes in NOD Mice ... Open the PDF for Combination Therapy With Epidermal Growth Factor and Gastrin Increases β-Cell Mass and Reverses Hyperglycemia ... Combination Therapy With Epidermal Growth Factor and Gastrin Increases β-Cell Mass and Reverses Hyperglycemia in Diabetic NOD ...
Combined modality therapy of locally advanced breast cancer. One institutions experience and a review of the literature. ... COMBINED MODALITY THERAPY OF LOCALLY ADVANCED BREAST-CANCER - ONE INSTITUTIONS EXPERIENCE AND A REVIEW OF THE LITERATURE ... We conclude that an aggressive combined modality approach to treatment of locally advanced breast cancer can result in ... RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy in different ways may kill ...
Combining one or more modalities of vibrational medicine can accelerate the healing process. In China, a woman who was open to ... Combining Vibrational Medicine Therapies. by Julia Fairfax and John Chate(more info) ... they employ a wide range of treatment modalities including Crystalline Structure Therapy, DNA and Cellular Re-patterning, ... Combined with poor diet, ingestion of drugs has a negative impact on the gut. Excessive consumption of alcohol, caffeine and ...
Check out NaturalTherapyPages.com.aus list of the best Bowen Therapy in Melbourne VIC. ... He combines the modalities of Homeopathy, Kinesiology and Bowen Therapy in his treatments. Rick begins his treatments by ... About Bowen Therapy in Melbourne VIC. What is Bowen Therapy?. The Bowen Therapy is a gentle form of neuromuscular bodywork that ... What are the Benefits of Bowen Therapy?. The Bowen Therapy is a unique type of manual therapy as it comes with the element of ...
  • Patients underwent concurrent cisplatin-based chemotherapy and radiation therapy (RT) after maximal transurethral resection of bladder tumor (TURBT) plus neoadjuvant or adjuvant chemotherapy. (urotoday.com)
  • Seventy-two percent of patients (78% with stage T2) had CR to induction therapy. (urotoday.com)
  • These results support modern bladder-sparing therapy as a proven alternative for selected patients. (urotoday.com)
  • Only 42 percent of the patients in the intraperitoneal-therapy group completed six cycles of the assigned therapy, but the median duration of progression-free survival in the intravenous-therapy and intraperitoneal-therapy groups was 18.3 and 23.8 months, respectively (P=0.05 by the log-rank test). (nih.gov)
  • Patients with one to three newly diagnosed brain metastases were randomly allocated either whole brain radiation therapy (WBRT) or WBRT followed by stereotactic radiosurgery boost. (nih.gov)
  • Regardless of stage, the current prognosis for patients with SCLC is unsatisfactory despite improvements in diagnosis and therapy during the past 25 years. (cancer.gov)
  • About 10% of the total population of SCLC patients remains free of disease during the 2 years from the start of therapy, which is the time period during which most relapses occur. (cancer.gov)
  • 6. Lomustine-TMZ as maintenance therapy might improve survival in newly diagnosed patients compared to maintenance TMZ alone, as suggested by an open-label phase 3 trial in 141 patients, which demonstrated a HR of 0.6 (95% CI 0.35-1.03, p=0.0492) for the combined treatment9. (orlandohealth.com)
  • The dilemma that we all face is deciding which pathways and modalities to choose in order to enhance treatment outcomes for our patients. (dentistrytoday.com)
  • The primary purpose of this study is to determine whether breast cancer tumors respond (as measured by pathologic complete response: the absence of microscopic evidence of invasive tumor cells in the breast) to combined chemotherapy of AC(doxorubicin and cyclophosphamide) followed by paclitaxel plus trastuzumab or lapatinib or both given before surgery to patients with HER2-positive breast cancer. (stanford.edu)
  • This seminar introduces the resident to the basics of seeing patients in the outpatient therapy setting. (uic.edu)
  • The focus is on practical aspects of the process, such as introducing the concepts of therapy to patients, setting the frame, billing, and documentation. (uic.edu)
  • As an expert radiation oncologist, Dr. David Kim, MD is skilled in administering radiation therapy to cancer patients. (kellysearch.com)
  • He utilises radiation therapy to help cancer patients in their recovery. (kellysearch.com)
  • The American Society of Radiation Oncology concludes the benefits of proton therapy may be even greater for pediatric patients. (covenanthealth.com)
  • Patients typically receive proton therapy five days a week for four to eight weeks. (covenanthealth.com)
  • Patients may be treated with surgery, chemotherapy, immunotherapy, targeted therapy or hormone therapy in addition to proton therapy. (covenanthealth.com)
  • Following the induction therapy, patients without disease progression received twice-weekly gemcitabine at 40 mg/m² and radiation. (cancernetwork.com)
  • The combination of concurrent fluorouracil (5-FU)and ionizing radiation therapy for patients with unresectable disease hasresulted in a twofold increase in median survival: approximately 10 months vs 5months. (cancernetwork.com)
  • Patients with bleeding esophageal varices were randomized into ligation or combination therapy groups. (unboundmedicine.com)
  • The aim of this study is to evaluate the dosemetric parameters and acute toxicity of dose-escalated whole pelvis (WP) Intensity Modulated Radiation Therapy (IMRT) and volumetric modulated arc therapy (VMAT) prostate boost following neoadjuvant and concomitant with androgen deprivation therapy in high-risk prostate cancer patients. (scirp.org)
  • Androgen deprivation therapy (ADT) was given for all patients before and during radiation therapy. (scirp.org)
  • In a Phase III trial, The Radiation Therapy Oncology Group (RTOG) showed improved progression-free survival (PFS) for high-risk prostate cancer patients treated with Whole Pelvis Radiation Therapy (WPRT) compared with prostate-only radiation therapy (PORT) [4]. (scirp.org)
  • Hence, there is increased interest in radiation dose escalation combined with androgen deprivation in high risk prostate cancer patients [6] [7]. (scirp.org)
  • Clinical scientists continue to observe superior survival of patients treated with combined chemotherapy and radiation approaches, yet the mechanisms behind this synergistic therapeutic approach are not fully understood. (mdanderson.org)
  • This is especially true in the treatment of young patients with radiation therapy. (mdanderson.org)
  • Upon completion of the combined degree program at the University of Pennsylvania, Dr. Chelsea Pinnix embarked on residency training in Radiation Oncology at the University of Texas MD Anderson Cancer Center. (mdanderson.org)
  • As multi-modality approaches to cancer continue to improve patient outcomes, limiting treatment related morbidity is essential. (mdanderson.org)
  • This is referred to as a multi-modality treatment. (hatcherfoundation.org)
  • Whether organ-conserving treatment by combined-modality therapy (CMT) achieves comparable long-term survival to radical cystectomy (RC) for muscle-invasive bladder cancer (BCa) is largely unknown. (urotoday.com)
  • Quality of life was significantly worse in the intraperitoneal-therapy group before cycle 4 and three to six weeks after treatment but not one year after treatment. (nih.gov)
  • Inference-based cognitive-behavioral therapy (I-CBT) is a specialized psychological treatment for obsessive-compulsive disorder (OCD) without deliberate and prolonged exposure and response prevention (ERP) that focuses on strengthening reality-based reasoning and correcting the dysfunctional reasoning giving rise to erroneous obsessional doubts and ideas. (karger.com)
  • Treatment protocols for advanced thyroid cancer have expanded in the past several years due to the increasing availability of targeted systemic therapies. (medscape.com)
  • Overall, the combined Dox and chi-p53 treatment exhibited enhanced cytotoxicity as compared to either Dox or chi-p53 treatments alone. (uky.edu)
  • Each treatment modality lasted 1 year. (psychiatrist.com)
  • However, at both follow-ups, differences between treatment modalities proved nonsignificant. (psychiatrist.com)
  • No fall-off in gains was observed for either treatment modality after treatment discontinuation. (psychiatrist.com)
  • Treatment options of unproven efficacy that are currently being studied include hyperbaric oxygen therapy, electrotherapy, growth factors , and negative-pressure wound therapy (NPWT). (medscape.com)
  • This combined modality treatment is considered the standard of care. (orlandohealth.com)
  • Pockets with bleeding on probing and a depth ≥ 5 mm may require additional soft-tissue treatment beyond traditional debridement therapy. (dentistrytoday.com)
  • Of particular interest are adjuvant therapy, treatment of metastatic disease, methods for treatment of locally advanced breast cancer and inflammatory breast cancer. (stanford.edu)
  • Each treatment is tailored to your specific needs and may include relaxation, remedial or other treatments combined into one session. (naturaltherapypages.com.au)
  • Different treatment modalities are often combined to help maximize results. (spokesman-recorder.com)
  • This widely used treatment will often be the therapy of choice for small and younger keloids. (spokesman-recorder.com)
  • If this treatment modality is chosen, it should be followed by monthly corticosteroid injections into the treated area, or in conjunction with other intralesional injections. (spokesman-recorder.com)
  • An antioxidant-rich extract of seaweed polyphenols combined with current PC treatment modalities may inhibit tumor relapse by targeting therapy-orchestrated autophagy in residual cells. (greenmedinfo.com)
  • What is proton therapy treatment? (covenanthealth.com)
  • Proton therapy enables physicians to precisely determine the shape, size, depth and dose of treatment to effectively treat tumors while avoiding and eliminating damage to nearby healthy organs and tissues. (covenanthealth.com)
  • The only certain way to know if proton therapy is the best option for your cancer treatment plan is to speak with a proton-experienced radiation oncologist. (covenanthealth.com)
  • Generally, if you have been diagnosed with cancer and radiation will be part of your treatment, then proton therapy may be right for you. (covenanthealth.com)
  • The proton therapy treatment team work to make your treatment as comfortable as possible. (covenanthealth.com)
  • Similar to conventional radiation, proton therapy delivers a total prescribed dose of radiation planned by the radiation oncologist and split into a number of treatment sessions called fractions. (covenanthealth.com)
  • Can proton therapy be combined with other treatment options? (covenanthealth.com)
  • Radiation therapy (RT) is a mainstay in the treatment of both primary and recurrent gastrointestinal (GI) and pelvic malignancies. (medscape.com)
  • The aXionXelect treatment table combines premium quality and comfort… at a budget-friendly price. (zimmerusa.com)
  • steroid-impregnated tape is the first-line treatment modality in Japan, while steroid (triamcinolone acetonide) injections are the treatment of choice in the USA [ 1 , 3 ]. (springer.com)
  • Students will be introduced to clinical assessment, goal setting, treatment planning, and outcome measurement from a physical therapy perspective. (caninerehabinstitute.com)
  • The primary treatment modality is surgery, although even with complete macroscopic resection, recurrence is common. (jnccn.org)
  • This study confirms that insulin resistance affects treatment outcome, and thus HOMA-IR testing before initiation of therapy may be a cost-effective tool. (who.int)
  • Usually, surgery is followed by treatment with radioiodine and thyroxine therapy. (medscape.com)
  • Generally, radiation therapy and chemotherapy do not have a prominent role in the treatment of thyroid cancer. (medscape.com)
  • The funding algorithm provides information on what anti-cancer systemic therapy treatments are covered on the BC Cancer Benefit Drug List (formulary). (bccancer.bc.ca)
  • To establish the long-term effectiveness of 3 treatments for DSM-IV panic disorder with or without agoraphobia: cognitive-behavioral therapy (CBT), pharmacotherapy using a selective serotonin reuptake inhibitor (SSRI), or the combination of both (CBT + SSRI). (psychiatrist.com)
  • Proton therapy is one of the most technologically advanced ways to deliver radiation treatments to cancerous tumors. (covenanthealth.com)
  • These treatments are combined according to the individual's case and can be delivered in various order, or some may be delivered during the same time period. (covenanthealth.com)
  • However, because no therapy has yet proven to be fully curative, keloid treatments have expanded to include a number of options, from injections to multimodal approaches. (springer.com)
  • Cancer treatments are also referred to as modalities. (hatcherfoundation.org)
  • Combining these modalities is of interest for combined chemo-/radiotherapy, bimodal imaging, and/or theranostic approach. (frontiersin.org)
  • It had substantial changes com- diotherapy [12], and chemotherapy-combined radiotherapy pared to the previous edition of classification published in 2007. (bvsalud.org)
  • The M. D. Anderson group,[12] and for an even longer time the group from the Fox-Chase Cancer Center,[ 13] have been the pioneers of upfront (neoadjuvant) therapy for potentially resectable pancreatic cancer and continue to be outspoken advocates of this concept. (cancernetwork.com)
  • Combined modality therapy of gastrointestinal tract cancer / P. Schlag, P. Hohenberger, U. Metzger (eds. (who.int)
  • It is not yet known whether chemotherapy is effective in treating women who have undergone surgery and radiation therapy for relapsed breast cancer. (stanford.edu)
  • Today, cancer claims more lives globally than HIV/AIDS, malaria, and tuberculosis combined, and the death toll from cancer is only going to grow. (health.am)
  • As with all forms of radiation therapy, proton therapy destroys cancer cells' ability to grow and divide by damaging the cells' DNA and causing them to die. (covenanthealth.com)
  • Cancer is often treated with several different modalities. (covenanthealth.com)
  • Proton therapy has been covered by Medicare since 1997 to treat most cancer diagnoses. (covenanthealth.com)
  • Nanomedicine, the use of nanoparticles (NPs) in medicine, is an ever-growing research field as illustrated by the huge amount of scientific publications and the important number of formulations registered for clinical trials, especially for cancer therapies ( 1 ). (frontiersin.org)
  • 10-12] Despite these limited benefits, many consider external beamradiation and concurrent 5-FU as the standard therapy for locally advancedpancreatic cancer. (cancernetwork.com)
  • Dose escalation in two phases utilizing Simultaneous integrated boost (SIB) combined with ADT in high risk prostate cancer patient is feasible and associated with acceptable acute GI and GU toxicity. (scirp.org)
  • Journal of Cancer Therapy , 10 , 654-670. (scirp.org)
  • Combined Modality Bladder-Sparing Therapy for Muscle-Invasive Bladder Cancer: How (Should) We Do It? (bvsalud.org)
  • We aimed to assess whether stereotactic radiosurgery provided any therapeutic benefit in a randomised multi-institutional trial directed by the Radiation Therapy Oncology Group (RTOG). (nih.gov)
  • The therapeutic efficiency of combined chemotherapy and gene therapy on human hepatocellular carcinoma HepG2 cells was investigated using double-walled microspheres that consisted of a poly(d,. l-lactic-co-glycolic acid) (PLGA) core surrounded by a poly(l-lactic acid) (PLLA) shell layer and fabricated via the precision particle fabrication (PPF) technique. (uky.edu)
  • Thus, we attempted to present an overview of previously published reports to evaluate the progress and provide molecular basis of mesenchymal stem cells (MSCs) therapy and its application in preclinical and clinical settings, which could aid in designing an effective regenerative therapeutic strategy in the future. (hindawi.com)
  • My therapeutic approach is person-centered and strength-based, combining modalities of cognitive behavioral therapy, motivational interviewing, solution-focused therapy and mindfulness. (psychologytoday.com)
  • Practical applications of joint mobilization, modalities, and therapeutic exercise will be covered. (caninerehabinstitute.com)
  • Repeat biopsy was performed after 40Gy, with initial tumor response guiding subsequent therapy. (urotoday.com)
  • The intent of vaccination is to induce a combined antibody and T-cell anti-HER-2 immune response, which is intended to target HER-2-expressing tumor cells, and may induce tumor regression or slow progression of disease. (stanford.edu)
  • Unlike radiation therapy that uses x-rays, proton therapy uses a beam of high-energy protons delivered directly into the tumor. (covenanthealth.com)
  • Traditional forms of radiation therapy use x-rays (photons), which deposit energy continuously from entering the body, through and beyond the tumor being treated into surrounding healthy tissue on the way to exit the body. (covenanthealth.com)
  • I take an integrative approach combining person-centered, CBT, body work, and psychodynamic modalities. (psychologytoday.com)
  • Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes. (childrensmercy.org)
  • The recent decade has seen encouraging outcomes of mesenchymal stem cell therapy that holds promise to alleviate the burden of neurological disorders Moreover, initial study data of preclinical trials have also indicated the effectiveness, tolerance, and safety of MSC-based therapy [ 10 ]. (hindawi.com)
  • If residual disease is found, adjuvant therapy with radioactive iodine (RAI) may be considered. (medscape.com)
  • Pisters and coauthors present and discuss a compelling argument for the theoretic benefit of neoadjuvant chemoradiation therapy directed at both the primary site of disease and systemic, microscopic metastatic disease before initiating the operative 'trauma' of curative resection. (cancernetwork.com)
  • Also, an updated analysis of the same study demonstrated improvement of PSA control and PFS at 10 years with added neoadjuvant hormonal therapy to WPRT [5]. (scirp.org)
  • This 660 hour program combines class time with hands-on practice of massage techniques. (isothermal.edu)
  • He combines his skills as a spiritual mentor and life coach with intuitive massage and the practice of energy healing modalities. (newsforthesoul.com)
  • With insights from her practice at Analog Earth Healing Hubb, Alicia explains how the physical manipulation of body tissues in massage therapy can enhance the flow of energy during energy work. (apple.com)
  • The question now becomes how to utilize such therapies in order to maximize results, yet keep costs within reason while minimizing side effects such as antibiotic resistance and pain. (dentistrytoday.com)
  • No universally accepted diagnostic criteria, laboratory tests, imaging studies or other modalities definitively diagnose or exclude burning mouth syndrome (BMS). (medscape.com)
  • Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used. (childrensmercy.org)
  • However, when combined with silicone sheets or other compression dressings, as well as radiation therapy soon after surgery, scar formation is reduced and keloids are less likely to recur. (spokesman-recorder.com)
  • If radiation therapy is considered in combination with surgery, you will also be referred to a radiation oncologist. (spokesman-recorder.com)
  • Some additional modalities include Nd:YAG lasers (Neodymium: Yttrium Aluminum Garnet), and 810 nm and 940 nm diode lasers. (dentistrytoday.com)
  • Initial nonoperative modalities include diet modification, nutritional support, and control of symptoms with medications. (medscape.com)
  • In the case of faulty crowns, temporary crowns are fabricated along with concomitant soft-tissue therapy and the final impressions may be taken weeks later. (dentistrytoday.com)
  • The 5 year survival rates are under 5% in most reported series.1,2 The standard of care continues to be chemotherapy with a duration of 4 - 6 cycles.3 The benefits of thoracic radiation therapy (TRT) have been demonstrated in numerous randomized trials for limited stage disease. (oncolink.org)
  • The median duration of overall survival in the intravenous-therapy and intraperitoneal-therapy groups was 49.7 and 65.6 months, respectively (P=0.03 by the log-rank test). (nih.gov)
  • Gliadel has been approved for GBM after surgical resection, based on trials performed before TMZ therapy was established7. (orlandohealth.com)
  • ISBT-Bowen Therapy is a dynamic and effective approach to pain and healing that will speed up recovery from injury for many Muscular - Skeletal & Visceral Health Issues. (naturaltherapypages.com.au)
  • My approach combines a variety of modalities, most im. (betterhelp.com)
  • The higher complication rate with combination therapy does not warrant this approach. (unboundmedicine.com)
  • Learn how these two modalities can harmoniously work together to provide a comprehensive approach to healing and relaxation. (apple.com)
  • Course reviews basic biochemistry and physiology crucial to understanding pharmacological therapies for psychiatric illnesses. (uic.edu)
  • Many Young Children with Autism Who Use Psychotropic Medication Do Not Receive Behavior Therapy: A Multisite Case-Control Study. (childrensmercy.org)
  • Early clinical studies combining irinotecan (CPT-11, Camptosar) and gemcitabine (Gemzar) have yielded encouraging results. (cancernetwork.com)
  • First-line therapy in ES-SCLC currently consists of chemotherapy, combining a platinum drug with either etoposide or irinotecan as a possible alternative. (ersjournals.com)
  • Listen to part two of this compelling episode, Alicia welcomes Jessica Davis, a Master Massage Therapist with decades of hands-on experience, to delve into the profound synergy between massage therapy and energetic work. (apple.com)
  • Listeners will journey through tales of transformative touch and the revelations clients have experienced when massage therapy harmoniously combines with energetic modalities. (apple.com)
  • Techniques that amplify the healing process when energetic work and massage therapy intertwine. (apple.com)
  • In the this of MicroDosing with Alicia, Season 5, Alicia explores the synergy between energy work and massage therapy. (apple.com)
  • Listen in to understand how energy work and massage therapy can complement each other to enrich your wellness journey. (apple.com)
  • Proton therapy is an advanced type of external beam radiation therapy. (covenanthealth.com)
  • However, despite having the promising outcome of preclinical studies, the clinical application of stem cell therapy remained elusive due to little or no progress in clinical trials. (hindawi.com)
  • The present study aimed to evaluate the effectiveness of I-CBT through a comparison with appraisal-based cognitive behavioral therapy (A-CBT) and an adapted mindfulness-based stress reduction (MBSR) intervention. (karger.com)
  • Recently, a growing number of studies are focusing on mesenchymal stem cell-based therapies for neurodegenerative disorders. (hindawi.com)
  • Combined Modality Therapy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (childrensmercy.org)
  • The therapy consists of multiple pathways in order to achieve periodontal success. (dentistrytoday.com)