Combinatorial Chemistry Techniques
Chemistry Techniques, Synthetic
Phosphinic Acids
Peptide Library
Drug Design
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
Chemistry Techniques, Analytical
Molecular Structure
Structure-Activity Relationship
Click Chemistry
Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.
A multiplasmid approach to preparing large libraries of polyketides. (1/942)
A three-plasmid system for heterologous expression of 6-deoxyerythronolide B synthase (DEBS) has been developed to facilitate combinatorial biosynthesis of polyketides made by type I modular polyketide synthases (PKSs). The eryA PKS genes encoding the three DEBS subunits were individually cloned into three compatible Streptomyces vectors carrying mutually selectable antibiotic resistance markers. A strain of Streptomyces lividans transformed with all three plasmids produced 6-deoxyerythronolide B at a level similar to that of a strain transformed with a single plasmid containing all three genes. The utility of this system in combinatorial biosynthesis was demonstrated through production of a library of modified polyketide macrolactones by using versions of each plasmid constructed to contain defined mutations. Combinations of these vector sets were introduced into S. lividans, resulting in strains producing a wide range of 6-deoxyerythronolide B analogs. This method can be extended to any modular PKS and has the potential to produce thousands of novel natural products, including ones derived from further modification of the PKS products by tailoring enzymes. (+info)Modelling G-protein-coupled receptors for drug design. (2/942)
The G-protein coupled receptors form a large and diverse multi-gene superfamily with many important physiological functions. As such, they have become important targets in pharmaceutical research. Molecular modelling and site-directed mutagenesis have played an important role in our increasing understanding of the structural basis of drug action at these receptors. Aspects of this understanding, how these techniques can be used within a drug-design programme, and remaining challenges for the future are reviewed. (+info)A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs. (3/942)
We have developed a method for producing sterically stabilized immunoliposomal drugs (SIL) readily applicable to a 'mix and match' combinatorial approach for the simple manufacture of a variety of ligand-targeted liposomal drugs. Ligands coupled to the terminus of polyethylene glycol (PEG) in micelles formed from PEG-lipid derivatives (mPEG2000-DSPE) could be transferred into preformed, drug-containing liposomes from the micelles in a temperature- and time-dependent manner. Antibody densities up to 100 microg antibody/micromol of phospholipid, and up to 3 mol% of mPEG2000-DSPE, could be simultaneously transferred from the ligand-coupled micelles into the liposomal outer monolayer with negligible drug leakage from liposomes during transfer and good stability in human plasma. Transfer of anti-CD19 into SIL resulted in a three-fold increase in binding of these liposomes to CD19+ human B cell lymphoma cells. (+info)Phagotopes derived by antibody screening of phage-displayed random peptide libraries vary in immunoreactivity: studies using an exemplary monoclonal antibody, CII-C1, to type II collagen. (4/942)
Antibody screening of phage-displayed random peptide libraries to identify mimotopes of conformational epitopes is promising. However, because interpretations can be difficult, an exemplary system has been used in the present study to investigate whether variation in the peptide sequences of selected phagotopes corresponded with variation in immunoreactivity. The phagotopes, derived using a well-characterized monoclonal antibody, CII-C1, to a known conformational epitope on type II collagen, C1, were tested by direct and inhibition ELISA for reactivity with CII-C1. A multiple sequence alignment algorithm, PILEUP, was used to sort the peptides expressed by the phagotopes into clusters. A model was prepared of the C1 epitope on type II collagen. The 12 selected phagotopes reacted with CII-C1 by both direct ELISA (titres from < 100-11 200) and inhibition ELISA (20-100% inhibition); the reactivity varied according to the peptide sequence and assay format. The differences in reactivity between the phagotopes were mostly in accord with the alignment, by PILEUP, of the peptide sequences. The finding that the phagotopes functionally mimicked the C1 epitope on collagen was validated in that amino acids RRL at the amino terminal of many of the peptides were topographically demonstrable on the model of the C1 epitope. Notably, one phagotope that expressed the widely divergent peptide C-IAPKRHNSA-C also mimicked the C1 epitope, as judged by reactivity in each of the assays used: these included cross-inhibition of CII-C1 reactivity with each of the other phagotopes and inhibition by a synthetic peptide corresponding to that expressed by the most frequently selected phagotope, RRLPFGSQM. Thus, it has been demonstrated that multiple phage-displayed peptides can mimic the same epitope and that observed immunoreactivity of selected phagotopes with the selecting mAb can depend on the primary sequence of the expressed peptide and also on the assay format used. (+info)Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides. (5/942)
Signalling by fibroblast growth factors (FGFs) through FGF receptors (FGFRs) depends on the cell-surface polysaccharide heparan sulphate (HS) [1] [2]. HS has an ordered domain structure of highly diverse saccharide motifs that present unique displays of sulphate, carboxyl and hydroxyl groups [3]. These motifs interact with many proteins, particularly growth factors. HS binds both to FGFs [4] [5] [6] and FGFRs [7], and probably activates signalling by facilitating ligand-induced receptor dimerisation [8] [9]. Nevertheless, the extent to which specific HS saccharide sequences play a regulatory role has not been established. By screening a library of structurally diverse HS decasaccharides in bioassays of FGF signalling mediated by three different FGFR isoforms, we found that saccharides showed specificity for both ligands and receptors; some saccharides selectively activated FGF signalling through different FGFR isoforms, others acted as negative regulators. We conclude that HS saccharides play critical roles in dictating the specificity of ligand-receptor interactions in FGFR signalling. Controlled alterations in HS structures [10] would provide a mechanism for regulation of cellular responsiveness to growth factors that bind HS. (+info)Combinatorial catalysis: identification of potent chiral catalysts through fluorescent bead signaling. (6/942)
Simultaneous labeling of beads with a fluorescent sensor and a unique catalyst allows chemists to identify the most active catalyst within a mixture. This approach is a valuable addition to the protocols available in the growing field of combinatorial catalysis. (+info)A loop-mimetic inhibitor of the HCV-NS3 protease derived from a minibody. (7/942)
We have been interested for some time in establishing a strategy for deriving lead compounds from macromolecule ligands such as minibody variants. A minibody is a minimized antibody variable domain whose two loops are amenable to combinatorial mutagenesis. This approach can be especially useful when dealing with 'difficult' targets. One such target is the NS3 protease of hepatitis C virus (HCV), a human pathogen that is believed to infect about 100 million individuals worldwide and for which an effective therapy is not yet available. Based on known inhibitor specificity (residues P6-P1) of NS3 protease, we screened a number of minibodies from our collection and we were able to identify a competitive inhibitor of this enzyme. We thus validated an aspect of recognition by HCV NS3 protease, namely that an acid anchor is necessary for inhibitor activity. In addition, the characterization of the minibody inhibitor led to the synthesis of a constrained hexapeptide mimicking the bioactive loop of the parent macromolecule. The cyclic peptide is a lead compound prone to rapid optimization through solid phase combinatorial chemistry. We therefore confirmed that the potential of turning a protein ligand into a low molecular weight active compound for lead discovery is achievable and can complement more traditional drug discovery approaches. (+info)Oligonucleotide-conjugated beads for transdominant genetic experiments. (8/942)
Transdominant genetics using expression libraries can identify proteins and peptides that affect cell division. In conjunction with these libraries, oligo-nucleotide-conjugated beads and flow cytometry were used to test a strategy that potentially expands the range of such genetic studies. The experimental approach involved creation of tagged expression libraries, introduction of these libraries into cells, growth of the cultured cells for several generations and recovery on oligonucleotide-conjugated beads of sequences that encode growth-modulatory proteins or peptides. Experiments in Saccharomyces cerevisiae demonstrating the feasibility of the strategy are presented. (+info)
Shimadzu
Swartz, Michael E. (2000-02-18). Analytical Techniques in Combinatorial Chemistry. CRC Press. pp. 278-279. ISBN 9780203909966. ...
Dynamic combinatorial chemistry
Several analytical techniques have been applied to the analysis of protein-directed DCL. These include HPLC, mass spectrometry ... Protein-directed dynamic combinatorial chemistry. In Dynamic combinatorial chemistry: in drug discovery, bioinorganic chemistry ... Center for Dynamic Combinatorial Chemistry[citation needed] University of Cambridge: Dynamic Combinatorial Chemistry (Wikipedia ... Dynamic combinatorial chemistry (DCC); also known as constitutional dynamic chemistry (CDC) is a method to the generation of ...
Combinatorial chemistry
Quite a few of available ones are already described Materials science has applied the techniques of combinatorial chemistry to ... formerly Journal of Combinatorial Chemistry) Combinatorial Chemistry Review Molecular Diversity Combinatorial Chemistry and ... The methods used in combinatorial chemistry are applied outside chemistry, too. Combinatorial chemistry had been invented by ... "The concealed side of the history of combinatorial chemistry" IUPAC's "Glossary of Terms Used in Combinatorial Chemistry" ACS ...
Prous Science
These techniques are complemented by laboratory methods from combinatorial chemistry, molecular biology and functional genomics ... statistical analysis and chemoinformatic techniques, a recent and innovative international concept registered under the name " ...
SMILES arbitrary target specification
A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry". ... RECAP (Retrosynthetic Combinatorial Analysis Procedure) uses SMARTS to define bond types. RECAP is a molecule editor which ... Methods and Principles in Medicinal Chemistry. pp. 271-285. doi:10.1002/3527603743.ch11. ISBN 9783527307531. Lyne, Paul D.; ... Lewell, Xiao Qing; Judd, Duncan B.; Watson, Stephen P.; Hann, Michael M. (1998). "RECAPRetrosynthetic Combinatorial Analysis ...
Molecule editor
A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry". ... Lewell, Xiao Qing; Judd, Duncan B.; Watson, Stephen P.; Hann, Michael M. (1998). "RECAP-Retrosynthetic Combinatorial Analysis ... Molecular structure input on the web The Chemical Structure Editor: Bridging Chemistry and Cheminformatics (Articles with short ... Methods and Principles in Medicinal Chemistry. pp. 271-285. doi:10.1002/3527603743.ch11. ISBN 9783527307531. ...
Scavenger resin
"Perspective articles on the utility and application of solution-phase combinatorial". Journal of Combinatorial Chemistry. 2 (2 ... Reaction may be monitored: The purification process is controlled Traditional purity techniques may be employed Can be used in ... Used primarily in the synthesis of medicinal drugs, solution-phase combinatorial chemistry allows for the creation of large ... Carlisle, Steven J. , Marsh, Andrew, Smith, S.C. (2001). "High-loading scavenger resins for combinatorial chemistry". ...
Combinatorial biology
Similar to combinatorial chemistry, compounds are produced by biosynthesis rather than organic chemistry. This process was ... Combinatorial biology techniques generally begin with large numbers of peptides, which are generated and screened by physically ... In biotechnology, combinatorial biology is the creation of a large number of compounds (usually proteins or peptides) through ... Combinatorial biology allows the generation and selection of the large number of ligands for high-throughput screening. ...
Micellar electrokinetic chromatography
The advent of combinatorial chemistry has enabled medicinal chemists to synthesize and identify large numbers of potential ... Micellar electrokinetic chromatography (MEKC) is a chromatography technique used in analytical chemistry. It is a modification ... Simms, P.J.; Jeffries, C.T.; Huang, Y.; Zhang, L.; Arrhenius, T.; Nadzan, A.M. (2001). "Analysis of Combinatorial Chemistry ... In MEKC, however, techniques must be used to extend the elution range to separate strongly retained analytes. Elution ranges ...
DNA-encoded chemical library
Scientific techniques, Drug discovery, Molecular biology, Combinatorial chemistry). ... DEL is used in medicinal chemistry to bridge the fields of combinatorial chemistry and molecular biology. The aim of DEL ... Combinatorial Chemistry 20 years on.., Drug DiscovToday 7; 1-4. Brenner S, Lerner RA (June 1992). "Encoded combinatorial ... Genetic manipulation of combinatorial chemistry libraries for small-molecule evolution". PLOS Biology. 2 (7): E174. doi:10.1371 ...
Organ bath
For studying the effects of drugs on receptors in drug discovery and combinatorial chemistry, novel techniques such as high ... These techniques can allow more receptor specificity than organ bath preparations, as a single tissue sample can express many ... Examples of important contributions made using this technique include: The 1921 discovery by Otto Loewi of Vagusstoff using ...
Systematic evolution of ligands by exponential enrichment
... is a combinatorial chemistry technique in molecular biology for producing oligonucleotides of either single-stranded DNA or RNA ... Combinatorial Chemistry & High Throughput Screening. 9 (8): 619-32. doi:10.2174/138620706778249695. PMID 17017882. Daniels DA, ... The technique has been used to evolve aptamers of extremely high binding affinity to a variety of target ligands, including ... Clinical uses of the technique are suggested by aptamers that bind tumor markers, GFP-related fluorophores, and a VEGF-binding ...
Christopher J. Schofield
... protein-directed dynamic combinatorial chemistry and organic synthesis/medicinal chemistry. Most clinically used antibiotics ... Techniques involved in this interdisciplinary research include proteomics, X-ray crystallography, nuclear magnetic resonance ( ... In 1998, he became professor of Chemistry, and in 2011 he was appointed the Head of Organic Chemistry at the Department of ... Chris Schofield is a professor of organic chemistry at the University of Oxford, Department of Chemistry and a Fellow of ...
Stuart Schreiber
"For outstanding achievement in creative chemistry." Eli Lilly Award in Biological Chemistry, ACS (1993). "For fundamental ... DOS pathways and new techniques for small-molecule screening provided many new, potentially disruptive insights into biology. ... combinatorial synthesis and the so-called Build/Couple/Pair strategy of modular chemical synthesis. ... Chemistry departments have changed their names to include the term chemical biology and new journals have been introduced (Cell ...
Yvonne Connolly Martin
... she developed combinatorial chemistry and molecular graphics techniques and was involved in the development of software ... She was the only woman to be a chemistry/zoology major in her year. From 1958 to 1960 she worked as a pharmacology assistant at ... Editorially, she has worked on Perspectives in Drug Design and Discovery, QSAR: Annual Reports in Computational Chemistry, ... She has also significantly contributed to the development of compound collections and combinatorial libraries which ...
Medicinal chemistry
... or from historic chemical compound collections or libraries created through combinatorial chemistry. While a number of ... approaches toward the identification and development of hits exist, the most successful techniques are based on chemical and ... Medicinal or pharmaceutical chemistry is a scientific discipline at the intersection of chemistry and pharmacy involved with ... Royal Society of Chemistry. doi:10.1039/9781782621836. ISBN 978-1-78262-419-6. Barret R (2018). Medicinal Chemistry: ...
The Billion-Dollar Molecule
... companies to adopt an explicit strategy of rational drug design as opposed to techniques based on combinatorial chemistry. This ...
School of Chemistry, University of Edinburgh
... the application of high throughput and combinatorial approaches and biophysical chemistry, which focuses on the development and ... application of physicochemical techniques to biological systems. Chemical Physics/Physical Chemistry is the fundamental study ... The Materials Chemistry group is one of the largest materials chemistry groups in the UK. Areas of strength include the design ... "RAE 2008: chemistry results". The Guardian. 18 December 2008. Retrieved 7 March 2019. "History of Chemistry - Is this going to ...
Franz-Josef Ulm
... an indentation technique that permits via statistical analysis to link chemistry and mechanical behavior at 10s of nanometer ... of a molecular combinatorial approach that concrete's fundamental strength could be elevated without changing the chemistry of ... The handshake of molecular simulation techniques with experimental nanoscale experiments opened a novel way to address the ... With his research group, he developed statistical nanoindentation techniques for hydrated nanocomposites; ...
Pesticide research
"Combinatorial chemistry in the agrosciences". Bioorganic & Medicinal Chemistry. 17 (12): 4035-46. doi:10.1016/j.bmc.2009.03.027 ... "Screening technique uncovers five new plant activator compounds". Phys.org. Retrieved 2014-02-11. Noutoshi Y, Okazaki M, Kida T ... The sources of new molecules employ natural products, competitors, universities, chemical vendors, combinatorial chemistry ... Techniques such as fragment-based design, virtual screening and genome sequencing have helped generate drug leads. Published ...
Polyanhydride
Journal of Combinatorial Chemistry, 7, 921-928, 2005. B.M. Vogel and S.K. Mallapragada, "The Synthesis of Polyanhydrides", in ... "Polyanhydride Synthesis Techniques." Wyatt Technology Corp. [2] Tamada, J. and Langer, R. "The development of polyanhydrides ... These classes are determined by examining their R groups (the chemistry of the molecule between the anhydride bonds). Aliphatic ...
Drug discovery
Protein-directed dynamic combinatorial chemistry". In Miller BL (ed.). Dynamic combinatorial chemistry: in drug discovery, ... Nuclear magnetic resonance spectroscopy is the primary technique for determining chemical structures of natural products. NMR ... selection of different binders from the same uridine-based dynamic combinatorial library". Journal of Combinatorial Chemistry. ... Despite the rise of combinatorial chemistry as an integral part of lead discovery process, natural products still play a major ...
Theoretical chemistry
Physical chemistry and chemical physics: Chemistry investigated via physical methods like laser techniques, scanning tunneling ... Examples are molecular docking, protein-protein docking, drug design, combinatorial chemistry. The fitting of shape and ... Theoretical chemistry is the branch of chemistry which develops theoretical generalizations that are part of the theoretical ... Theoretical chemistry unites principles and concepts common to all branches of chemistry. Within the framework of theoretical ...
Materials informatics
Some more narrow interpretations include combinatorial chemistry, Process Modeling, materials property databases, materials ... This lack of big data has led to growing effort in developing machine learning techniques that utilize data extremely data sets ...
Fluorescence polarization immunoassay
Nasir M (1999). "Fluorescence Polarization: An Analytical Tool for Immunoassay and Drug Discovery". Combinatorial Chemistry & ... Despite originating as a method for direct interaction studies, the technique has been adopted by high-throughput screening ( ... Jameson D (2003). "Fluorescence Polarization: Past, Present and Future". Combinatorial Chemistry & High Throughput Screening. 6 ... Eremin SA, Smith DS (May 2003). "Fluorescence polarization immunoassays for pesticides". Combinatorial Chemistry & High ...
Solid-phase synthesis
The method of choice is generally phosphoramidite chemistry, developed in the 1980s. Combinatorial chemistry Noncovalent solid- ... Solid-phase synthesis is a common technique for peptide synthesis. Usually, peptides are synthesised from the carbonyl group ... Solid-Phase Combinatorial Chemistry, see [1] N-(pyrimidin-2-yl)amino acid amides in drug research, see Full article (Articles ... More recently, this method has also been used in combinatorial chemistry and other synthetic applications. The process was ...
Invitae
The CombiMatrix microarray ("CombiMatrix" refers to combinatorial chemistry on a matrix array) was born and received US patents ... CombiMatrix performs genetic testing utilizing a variety of advanced cytogenomic techniques, including chromosomal microarray ...
Structure-activity relationship
Combinatorial chemistry Congener Conformation activity relationship Quantitative structure-activity relationship Pharmacophore ... Medicinal chemists use the techniques of chemical synthesis to insert new chemical groups into the biomedical compound and test ... Molecular Property Explorer QSAR World (AC with 0 elements, Medicinal chemistry). ... Environmental Toxicology and Chemistry. 5 (6): 503-509. doi:10.1002/etc.5620050601. Alexander, Martin; Lustigman (1966). " ...
Host-guest chemistry
... is one of the most powerful spectroscopic techniques in analytical chemistry. It is an important tool for the studies of host- ... and by doing so hope to gain further insight into the combinatorial outcome of these many, small, non-covalent forces that are ... Host-guest chemistry is a branch of supramolecular chemistry in which a host molecule forms a chemical compound with a guest ... In supramolecular chemistry, host-guest chemistry describes complexes that are composed of two or more molecules or ions that ...
Chemical biology
These combinatorial chemistry approaches are identical to those employed in the discipline of pharmacology. Many research ... Although strictly biological techniques have been developed to achieve these ends, the chemical synthesis of peptides often has ... Bioorganic & Medicinal Chemistry - The Tetrahedron Journal for Research at the Interface of Chemistry and Biology ChemBioChem ... Chemical biology has scientific, historical and philosophical roots in medicinal chemistry, supramolecular chemistry, ...
Phage display
In this technique, a gene encoding a protein of interest is inserted into a phage coat protein gene, causing the phage to " ... Smith and Winter were awarded a half share of the 2018 Nobel Prize in chemistry for their contribution to developing phage ... Barbas CF, Kang AS, Lerner RA, Benkovic SJ (September 1991). "Assembly of combinatorial antibody libraries on phage surfaces: ... The technique is also used to determine tumour antigens (for use in diagnosis and therapeutic targeting) and in searching for ...
RNA-targeting small molecule drugs
In 2007, Miller and coworkers used dynamic combinatorial chemistry to screen a compound library against HIV-1 frameshift ... Thus, more research groups have implemented these techniques in their programs. In a leading example, Al-Hashimi and coworkers ... Velagapudi, Sai Pradeep; Disney, Matthew D (2014). "Two-dimensional combinatorial screening enables the bottom-up design of a ... This work combined with advances in structural characterization techniques such as NMR spectroscopy and X-ray crystallography ...
Universal Decimal Classification
Preparative and experimental chemistry 543 Analytical chemistry 544 Physical chemistry 546 Inorganic chemistry 547 Organic ... Memoirs 82.02/.09 Special auxiliary subdivision for theory, study and technique of literature 82.02 Literary schools, trends ... and general considerations of mathematics 511 Number theory 512 Algebra 514 Geometry 517 Analysis 519.1 Combinatorial analysis ... Solid state physics 539 Physical nature of matter 54 Chemistry. Crystallography. Mineralogy 542 Practical laboratory chemistry ...
High-entropy alloy
Magnetron Sputtering technique is the most-used method to fabricate the HEAFs. An inert gas (Ar) is introduced in a vacuum ... Ruiz-Yo, Benjamine (2016). "The Different Roles of Entropy and Solubility in High Entropy Alloy Stability". ACS Combinatorial ... Inorganic Chemistry. 57 (4): 2103-2110. doi:10.1021/acs.inorgchem.7b03004. PMID 29389120. Edalati, P.; Floriano, R.; Mohammadi ... summarized three routes to prepare HEAFs via the magnetron sputtering technique. First, a single HEA target can be used to ...
Fluorescence in situ hybridization
The specifics depend on the specific FISH technique used. For miRNA detection, the probes use proprietary chemistry for ... It uses combinatorial labeling, followed by imaging, and then error-resistant encoding to capture a high number of RNA ... FISH is a very general technique. The differences between the various FISH techniques are usually due to variations in the ... it may lead to more portable diagnostic techniques. FISH has been extensively studied as a diagnostic technique for the ...
Protein function prediction
This technique is a computational adaptation of 'wet lab' work from 1996. It was discovered that ascertaining the structure of ... Shindyalov IN, Bourne PE (September 1998). "Protein structure alignment by incremental combinatorial extension (CE) of the ... Computational Biology and Chemistry. 61: 23-38. doi:10.1016/j.compbiolchem.2015.12.004. PMID 26773655. Garma LD, Medina M, ... While techniques such as microarray analysis, RNA interference, and the yeast two-hybrid system can be used to experimentally ...
Olfactory receptor
Such data open the way to the deciphering of the combinatorial code of the perception of smells. Such diversity of OR ... Crabtree RH (1978). "Copper (I): A possible olfactory binding site". Journal of Inorganic and Nuclear Chemistry. 40 (7): 1453. ... Deorphanization of odor receptors can be completed using electrophysiological and imaging techniques to analyze the response ... Malnic B, Hirono J, Sato T, Buck LB (March 1999). "Combinatorial receptor codes for odors". Cell. 96 (5): 713-23. doi:10.1016/ ...
Fragment-based lead discovery
Druglikeness Protein-directed dynamic combinatorial chemistry Lipinski's rule of five Price AJ, Howard S, Cons BD (November ... FBLD is a technique being used in research for discovering novel potent inhibitors. This methodology could help to design ... Many biophysical techniques have been applied to address this issue. In particular, ligand-observe nuclear magnetic resonance ( ... Topics in Current Chemistry. Vol. 317. pp. 1-32. doi:10.1007/128_2011_180. ISBN 978-3-642-27539-5. PMID 21695633. Edward ...
Hanoch Senderowitz
In 2009, he joined Bar Ilan University as an associate professor at the Department of Chemistry leading the molecular modeling ... ISBN 978-953-51-2592-1. Arup Ghose; Vellerkad Viswanadhan (26 June 2001). Combinatorial Library Design and Evaluation: ... different computational techniques, and different machine learning algorithms. Senderowitz is known for the following areas of ... ISBN 978-0-8247-0487-2. Patai, Saul (1996). The chemistry of amino, nitroso, nitro, and related groups. Chichester England New ...
Emmy Noether
Techniques such as Hilbert's original non-constructive solution to the finite basis problem could not be used to get ... She had three younger brothers: the eldest, Alfred, was born in 1883, was awarded a doctorate in chemistry from Erlangen in ... Noether is credited with fundamental ideas that led to the development of algebraic topology from the earlier combinatorial ... she first became acquainted with a systematic construction of combinatorial topology, she immediately observed that it would be ...
List of University of Wisconsin-Madison people
... recipient of the Nobel Prize in Chemistry in 2000 Stanford Moore, Ph.D. 1938, recipient of the Nobel Prize in Chemistry in 1972 ... professor of combinatorial mathematics Robert V. Bruce, winner of the 1988 Pulitzer Prize for History Edgar Buckingham, ... surgeon and developer of the Mohs surgery technique for removing types of skin cancer Howard Moore, head coach of the UIC ... professor emeritus of chemistry James Dahlberg, professor emeritus of biomolecular chemistry Farrington Daniels, early ...
MicroRNA
Combinatorial regulation is a feature of miRNA regulation in animals. A given miRNA may have hundreds of different mRNA targets ... Zheng H, Fu R, Wang JT, Liu Q, Chen H, Jiang SW (April 2013). "Advances in the techniques for the prediction of microRNA ... The Journal of Biological Chemistry. 282 (17): 12363-7. doi:10.1074/jbc.C700015200. PMID 17344217. Yang B, Lin H, Xiao J, Lu Y ... Chemistry & Biology. 22 (2): 262-72. doi:10.1016/j.chembiol.2014.12.013. PMID 25641166. Sohel MH (2016). "Extracellular/ ...
Kim Janda
"Synthetic methods for the implementation of encoded combinatorial chemistry". Journal of the American Chemical Society. 115 (21 ... Another area of medicinal research in which the Janda laboratory has made contributions encompasses techniques to create ... He then studied at the University of Arizona and obtained a M.S. in organic chemistry (1983) and a Ph.D. in 1984. He carried ... Han, H.; Wolfe, M. M.; Brenner, S.; Janda, K. D. (July 3, 1995). "Liquid-phase combinatorial synthesis". Proceedings of the ...
Block design
ISBN 978-981-4480-23-9. Ryser, Herbert John (1963), "8. Combinatorial Designs", Combinatorial Mathematics, Carus Mathematical ... These designs were especially useful in applications of the technique of analysis of variance (ANOVA). This remains a ... physical chemistry, software testing, cryptography, and algebraic geometry. Without further specifications the term block ... Journal of Combinatorial Theory, 9 (2): 174-191, doi:10.1016/S0021-9800(70)80024-2 Stinson, Douglas R. (2003), Combinatorial ...
Polyomino
Combined with the use of generating functions, this technique is able to count many polyominoes at once, thus enabling it to ... Golomb, Solomon W. (1970). "Tiling with Sets of Polyominoes". Journal of Combinatorial Theory. 9: 60-71. doi:10.1016/S0021-9800 ... is applied to problems in physics and chemistry. Polyominoes have been used as models of branched polymers and of percolation ... The traditional approach to tiling finite regions of the plane uses a technique in computer science called backtracking. In ...
Ambient ionization
Crotti, Sara; Traldi, Pietro (2009). "Aspects of the Role of Surfaces in Ionization Processes". Combinatorial Chemistry & High ... A Flexible Multimode Ambient Ion Generation Technique". Analytical Chemistry. 81 (18): 7788-7794. doi:10.1021/ac9014098. ISSN ... One of the most used plasma-based techniques for ambient ionization is probably Direct analysis in real time (DART), since it ... In the table below, ambient ionization techniques are classified in the categories "extraction" (a solid or liquid extraction ...
Genome editing
This technique has further implications in eradicating other vector borne diseases such as yellow fever, dengue, and Zika. The ... 2006). "A combinatorial approach to create artificial homing endonucleases cleaving chosen sequences". Nucleic Acids Research. ... "The Nobel Prize in Chemistry 2020". Nobel Foundation. Archived from the original on 7 October 2020. Retrieved 7 October 2020. " ... These techniques were also used to remove marker genes from transgenic animals. Further modifications of these systems allowed ...
Biochip
Furthermore, light-directed combinatorial synthesis techniques are not currently possible for proteins or other sensing ... Surface chemistry is used to covalently bind the sensor molecules to the substrate medium. The fabrication of microarrays is ... Although this technique is very powerful in that many sensors can be created simultaneously, it is currently only feasible for ... One of the first portable, chemistry-based sensors was the glass pH electrode, invented in 1922 by Hughes. The basic concept of ...
Edwin Southern
His 'blot' technique, for the identification of specific sequences among large populations of fragments generated by ... He went on to read Chemistry at the University of Manchester (BSc Hons., 1958). He continued as a graduate student (then ... Milner, N.; Mir, K. U.; Southern, E. M. (1997). "Selecting effective antisense reagents on combinatorial oligonucleotide arrays ... Demonstrator, 1963) in the Department of Chemistry, University of Glasgow, where he was awarded his PhD in 1962. Southern is ...
Protocell
Starting with a technique commonly used to deposit molecules on a solid surface, Langmuir-Blodgett deposition, scientists are ... Topics in Current Chemistry. 259: 1-27. doi:10.1007/b136806. ISBN 3-540-27759-5. Walde, P (2006). "Surfactant Assemblies and ... argue that biomolecules would become trapped within these pore systems upon polymerization and would not undergo combinatorial ... The technique could help astrobiologists understand how the first living cells originated. Jeewanu protocells are synthetic ...
Richard A. Houghten
He had previously received a BS in chemistry from California State University, Fresno and an M.S. in Chemistry from Berkeley. ... Combinatorial biology is the generation of large numbers of molecules (usually peptides, enzymes or other polypeptides in ... and then assayed by some technique. Very precise deconvolution of the results, or alternatively, marking the peptide beads, can ... In 1991, he and his colleagues published one of the major papers in combinatorial biology-the paper described a method to ...
List of Guggenheim Fellowships awarded in 2000
Ernesto Julio Calvo, Professor of Physical Chemistry, University of Buenos Aires: A study of self-assembled proteins at ... John Stembridge, Professor of Mathematics, University of Michigan: Combinatorial aspects of root systems and Weyl characters. ... New query and search techniques for the Internet. Jennette Williams, Photographer, New York City; Instructor in Photography, ... Robert J. Hamers, Evan P. Helfaer Professor of Chemistry, University of Wisconsin-Madison: Studies in molecular electronics. ...
Travelling salesman problem
Bellman, R. (1960), "Combinatorial Processes and Dynamic Programming", in Bellman, R.; Hall, M. Jr. (eds.), Combinatorial ... The Lin-Kernighan heuristic is a special case of the V-opt or variable-opt technique. It involves the following steps: Given a ... In the following decades, the problem was studied by many researchers from mathematics, computer science, chemistry, physics, ... Similarly, the 3-opt technique removes 3 edges and reconnects them to form a shorter tour. These are special cases of the k-opt ...
Partition coefficient
Wang J, Hou T (June 2011). "Recent advances on aqueous solubility prediction". Combinatorial Chemistry & High Throughput ... and pH-metric techniques.: 280 In this method the solid particles present into the two immiscible liquids can be easily ... Combinatorial Chemistry & High Throughput Screening. 4 (6): 453-75. doi:10.2174/1386207013330896. PMID 11562252. Schuffenhauer ... Physical chemistry, Equilibrium chemistry, Medicinal chemistry, Solvents). ...
Digital microfluidics
"On-chip drop-to-drop liquid microextraction coupled with real-time concentration monitoring technique". Analytical Chemistry. ... Jebrail MJ, Assem N, Mudrik JM, Dryden MD, Lin K, Yudin AK, Wheeler AR (2012-08-01). "Combinatorial Synthesis of ... Analytical and bioanalytical chemistry". Analytical and Bioanalytical Chemistry. 397 (3): 991-1007. doi:10.1007/s00216-010-3678 ... In one example of this technique, a Grieco three-component condensation was carried out on chip and was taken off the chip by ...
Niranjan Parajuli
... protein engineering and combinatorial chemistry. He is also active in research using applied biophysics in the field of ... Importance of advanced analytical techniques and methods for food quality control and pollution analysis for more sustainable ... and Professor of Chemistry at the Central Department of Chemistry, Tribhuvan University, Nepal. Parajuli is also an advocate ... He then, completed his Master of Science degree majoring in Chemistry from the same university, passing with a distinction, and ...
Social golfer problem
The SGP has been used to assign students into groups in undergraduate chemistry classes and breakout rooms in online meeting ... In discrete mathematics, the social golfer problem (SGP) is a combinatorial-design problem derived from a question posted in ... There are many approaches to solving the SGP, namely design theory techniques, SAT formulations (propositional satisfiability ... First is the large search space resulting from the combinatorial and highly symmetrical nature of the problem. There are a ...
Scanning electrochemical microscopy
Since then, the theoretical underpinnings have matured to allow widespread use of the technique in chemistry, biology and ... "Combinatorial Electrochemistry: A Highly Parallel, Optical Screening Method for Discovery of Better Electrocatalysts". Science ... Unlike dc-SECM techniques ac-SECM does not require the use of a redox mediator. This is particularly advantageous for ... The technique is complementary to other surface characterization methods such as surface plasmon resonance (SPR), ...
Browsing Technical documents by Subject "Combinatorial Chemistry Techniques"
Combinatorial Library of Cyclic Benzylidene Acetal-Containing pH-Responsive Lipidoid Nanoparticles for Intracellular mRNA...
Combinatorial Chemistry Techniques* Actions. * Search in PubMed * Search in MeSH * Add to Search ... Tailoring combinatorial lipid nanoparticles for intracellular delivery of nucleic acids, proteins, and drugs. Li Y, Ye Z, Yang ... Combinatorial Library of Light-Cleavable Lipidoid Nanoparticles for Intracellular Drug Delivery. Li Y, Chakraborty A, Chen J, ... Combinatorial library strategies for synthesis of cationic lipid-like nanoparticles and their potential medical applications. ...
Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by...
Combinatorial Chemistry Techniques Actions. * Search in PubMed * Search in MeSH * Add to Search ... Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by ... Combinatorial interaction between two human serotonin transporter gene variable number tandem repeats and their regulation by ... The level of reporter gene activity from the dual VNTR constructs indicated combinatorial action between the two domains. ...
Center for Nonlinear and Complex Systems at Duke University
Eric Freeman | MIT Technology Review
"Its basically combinatorial chemistry for proteins," says Deem. The payoff could be a powerful new technique for finding ... By making an analogy between a computer simulation technique called Monte Carlo and combinatorial chemistry, Deem has provided ... Clemmers method also could provide a screening technique for combinatorial chemistry-a drug discovery process that produces ... The potential of combinatorial chemistry? Shortened timescales for finding new materials, and the ability to search a broader ...
BIOTECHNO 2013 Call for Papers
Combinatorial chemistry; Graph theory in chemistry; Prediction of drug toxicity; Property prediction; Molecular mechanics and ... Biotechnology is defined as the industrial use of living organisms or biological techniques developed through basic research. ... Bioimaging ( Image processing in medicine and biological sciences; Measurements techniques; Mass spectrometry; Numerical( ... Mathematical chemistry and chemical graphs; In silico environmental toxicology; Computer-assisted chemical engineering; ...
DeCS - Termos Novos
Publication Detail
MeSH Terms: Animals; Binding Sites; Biological Assay; Combinatorial Chemistry Techniques; Dioxins/pharmacology; Genes, Reporter ... 4-dinitrobenzene combinatorial chemical library consisting of 155 parental amines and up to 12 090 combinatorial products in ... and also have revealed several novel products of the combinatorial chemical library synthesis with EC(50)s between 10 and 100 ...
NIH Guide: MOLECULAR TARGET DRUG DISCOVERY FOR CANCER: SMALL BUSINESS GRANTS
... and combinatorial chemistry to generate large numbers of candidate drug structures. INCLUSION OF WOMEN AND MINORITIES IN ... and computational techniques to allow the determination of three-dimensional structure; advances in screening technology to ... such as assay development or combinatorial chemistry library generation to assist target validation might be more suitable than ... molecular structure determined through biophysical techniques as a prelude to drug discovery studies . These aspects are ...
Welcome to Scientific collaborations - Solvay Pharmaceuticals
This collaboration combines ArQules advanced combinatorial chemistry techniques with Solvays in house know-how of ... Solvay Pharmaceuticals is using ArQules combinatorial chemistry technology in two important ways. First, to broadly test new ... Solvay Pharmaceuticals combines its own strengths in pharmacology, biotechnology and chemistry with:. * ArQule for the ... One program aims at identifying brain areas that are affected by schizophrenia using advanced imaging techniques (MRI).. ...
Marine Drugs | Free Full-Text | Extract from the Zooxanthellate Jellyfish Cotylorhiza tuberculata Modulates Gap Junction...
High-throughput screening, combinatorial chemistry and, most recently, in silico virtual screening techniques partly supported ... GJIC was assessed using the SL/DT technique described by El-Fouly [146]. Cells were seeded at 6 × 105 cells/plate (HEKa) and at ... El-Fouly, M.H.; Trosko, J.E.; Chang, C.-C. Scrape-loading and dye transfer: A rapid and simple technique to study gap ... A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook ...
The Chemistry of Life｜Kyoto University OpenCourseWare
Unit 7: Combinatorial Chemistry & Chemical Genetics. Unit 8: Fluorescent Molecules for Tracking Biology. Unit 9: Fluorescent ... Unit 4: Idea Generation Techniques. Unit 5: Writing Amino Acids. Unit 6: Writing and Synthesizing Proteins. ... The Chemistry of Life. Unit 0 - Impacts of The Chemistry of Life Motonari Uesugi ... How to use chemistry for biology. ・How to control biological events by chemical means. ・How to integrate chemistry and biology ...
Combichem all over again | Nature Chemistry
Combinatorial chemistry, the preparation of large diverse libraries of new compounds from defined building blocks, is such a ... potentially powerful technique that it has had multiple lives. The first flush of enthusiasm for it in the early 1990s did not ... Nature Chemistry (Nat. Chem.) ISSN 1755-4349 (online) ISSN 1755-4330 (print) ...
MeSH Browser
Chemistry Technique, Combinatorial Chemistry Techniques, Combinatorial Combinatorial Chemistry Technic Combinatorial Chemistry ... Combinatorial Chemistry Technique Technic, Combinatorial Chemistry Technics, Combinatorial Chemistry Technique, Combinatorial ... Chemistry Techniques, Synthetic [E05.197] * Click Chemistry [E05.197.124] * Combinatorial Chemistry Techniques [E05.197.312] * ... Chemistry Techniques, Synthetic [J01.897.836.249] * Click Chemistry [J01.897.836.249.124] * Combinatorial Chemistry Techniques ...
Yuri Alexeev | Argonne Leadership Computing Facility
Quantum Chemistry Algorithms. Quantum Combinatorial Optimization Algorithms. Classical And Quantum Machine Learning. Quantum ... His research involves development of quantum computing algorithms, error correction/mitigation techniques, and numerical ... The recent projects include development of quantum chemistry and combinatorial optimization quantum algorithms for NISQ quantum ... Alexeev received his PhD in Physical Chemistry from Iowa State University while a graduate student in Mark Gordons quantum ...
Biomarkers Search
... a detection method for combinatorial chemistry.. Fischer M; Tran CD. Anal Chem; 1999 Jul; 71(13):2255-61. PubMed ID: 10405595. ... Evidence for kinetic inhomogeneity in the curing of epoxy using the near-infrared multispectral imaging technique.. Fischer M; ... Investigation of solid-phase peptide synthesis by the near-infrared multispectral imaging technique: ...
Testimony on the Fiscal Year 2012 Budget Request before the Senate Committee | National Institutes of Health (NIH)
... using semiconductor manufacturing techniques, melded with advances in combinatorial chemistry to capture vast amount of ... Collins received a B.S. in chemistry from the University of Virginia, a Ph.D. in physical chemistry from Yale University, and ... Collins received a B.S. in chemistry from the University of Virginia, a Ph.D. in physical chemistry from Yale University, and ... NIH research has enabled new techniques to prevent heart attacks, newer and more effective drugs for lowering cholesterol and ...
Lectin Techniques for Glycoproteomics
| Bentham Science
Combinatorial Chemistry & High Throughput Screening Bioconversion of Isoflavones into Bioactive Equol: State of the Art. Recent ... Current Medicinal Chemistry Bone Regeneration and Repair. Current Stem Cell Research & Therapy Harnessing Phage Display for the ... Current Medicinal Chemistry Bispecific Antibodies: An Innovative Arsenal to Hunt, Grab and Destroy Cancer Cells. Current ... Current Medicinal Chemistry Significance of Prion and Prion-Like Proteins in Cancer Development, Progression and Multi-Drug ...
NIAAA Director's Statement before the House Committee on Appropriations Subcommittee on Labor, Health and Human Services,...
With the help of computers and powerful methods of combinatorial chemistry to create hundreds of new potential compounds ... Alcohol scientists are using advanced neuroscience techniques (e.g., patch clamping, imaging, electrophysiology, neurochemistry ... and statistical genetics and molecular biology techniques are being applied to "informative" families. Phenotypic markers shown ... which our understanding of the shape and structure of important molecules in the body is dramatically improved with techniques ...
DeCS
Chemistry Technique, Combinatorial Chemistry Techniques, Combinatorial Combinatorial Chemistry Technic Combinatorial Chemistry ... Combinatorial Chemistry Technique Technic, Combinatorial Chemistry Technics, Combinatorial Chemistry Technique, Combinatorial ... Chemistry Technic, Combinatorial. Chemistry Technics, Combinatorial. Chemistry Technique, Combinatorial. Chemistry Techniques, ... Combinatorial Chemistry. Technics, Combinatorial Chemistry. Technique, Combinatorial Chemistry. Techniques, Combinatorial ...
MeSH Browser
Chemistry Technique, Combinatorial Chemistry Techniques, Combinatorial Combinatorial Chemistry Technic Combinatorial Chemistry ... Combinatorial Chemistry Technique Technic, Combinatorial Chemistry Technics, Combinatorial Chemistry Technique, Combinatorial ... Chemistry Techniques, Synthetic [E05.197] * Click Chemistry [E05.197.124] * Combinatorial Chemistry Techniques [E05.197.312] * ... Chemistry Techniques, Synthetic [J01.897.836.249] * Click Chemistry [J01.897.836.249.124] * Combinatorial Chemistry Techniques ...
Vauthey Research Group - Group Members
Department of Chemistry, Saitama University (Japan). Control of Self-Organizing Systems by Laser Techniques ... Complex Topologies and Structural Divergence in Dynamic Combinatorial Chemistry Org.: Prof. Sascha Hoogendoorn. --- CANCELLED ... All Chemistry. Organic chemistry. Inorganic and analytical chemistry. Physical chemistry. Biochemistry. NCCR Chemical Biology. ... Ulm University, Institute of Organic Chemistry, Ulm, Germany. New Tools and Uses of Dynamic Covalent Chemistry ...
RFA-HD-09-012: Intellectual and Developmental Disabilities Research Centers 2010 (P30)
... combinatorial chemistry, pharmacogenomics); medication use and treatment efficacy in different subpopulations of IDD and in ... Prenatal therapy of genetic and structural defects using nutritional, pharmacological, surgical, and other techniques. ... such studies might use techniques of imaging, electrophysiology, pharmacology, molecular biology, and behavioral science. ...
From Micrograms To Multikilos
RFA-RM-08-003: Pilot-Scale Libraries (PSL) for High-Throughput Screening (P41)
... often referred to as combinatorial chemistry, combichem, or diversity-oriented synthesis); 2) isolation and purification of ... HT synthesis may use solid- and/or solution-phase reaction and product isolation techniques. A library produced by HT synthesis ... optimization via medicinal chemistry. In order to optimize the use of medicinal chemistry resources within the MLP, PSL ... Chief, Biological Chemistry and Macromolecular Biophysics (BCMB) IRG. Center for Scientific Review. National Institutes of ...
Simultaneous disulfide and boronic acid ester exchange in dynamic combinatorial libraries - All staff at the Department of...
Dynamic combinatorial chemistry has emerged as a promising tool for the discovery of complex receptors in supramolecular ... We describe the detailed studies necessary to establish suitable reaction conditions and highlight the analytical techniques ... At the heart of dynamic combinatorial chemistry are the reversible reactions that enable the exchange of building blocks ... Department of Chemistry. University of Copenhagen Universitetsparken 5. DK-2100 Copenhagen O ...
DeCS - Termos Novos
DeCS - Termos Novos
Aldehydes. Medical search
Combinatorial Chemistry Techniques. A technology, in which sets of reactions for solution or solid-phase synthesis, is used to ... Lipid PeroxidationCyclizationAmino Acid SequenceOrganic Chemistry ProcessesVolatilizationCombinatorial Chemistry Techniques ... SpectroscopyAminesSemicarbazidesOrganic Chemistry ProcessesBoranesVolatilizationIminesCombinatorial Chemistry Techniques ... High Pressure LiquidMagnetic Resonance SpectroscopyCombinatorial Chemistry TechniquesMass Spectrometry ...
High ThroughpuBiotechnologyAssaySynthesisCurrent BioinformaticsLibrariesAlgorithmsAssaysApproachesBiologyOrganic chemistryAnalytical techniquesCombichemLibraryPhysicsNumericalTechnologyCompoundsDevelopmentDataResearchInterestHumanPreparationDiscoverySingleMethodsStudiesTechnologiesGroupPhysicalAnalysisBasicMultipleEffective
High Throughpu2
- The number of new chemical entities (NCE) is increasing every day after the introduction of combinatorial chemistry and high throughput screening to the drug discovery cycle. (aston.ac.uk)
- Combinatorial chemistry and high-throughput screening accelerate the research and development of new medicines. (alfa-chemistry.com)
Biotechnology2
- Biotechnology is defined as the industrial use of living organisms or biological techniques developed through basic research. (iaria.org)
- Before coming to NIH, Inglese led research teams at the Princeton-based combinatorial chemistry biotechnology company Pharmacopeia, Inc., and at Merck Research Laboratories. (nih.gov)
Assay2
- Since the SBIR and STTR mechanisms require the research to result in a commercial product (see "Mechanism of Support"), it would seem that projects such as assay development or combinatorial chemistry library generation to assist target validation might be more suitable than, for example, target identification. (nih.gov)
- To advance a more efficient drug discovery model, Inglese's laboratory conducts research in high-throughput techniques, assay technologies and analysis methods for large-scale qHTS data. (nih.gov)
Synthesis4
- These analyses have identified numerous parental amines as relatively potent inducers of EGFP (with EC(50)s between 8 and 1000 microM) and also have revealed several novel products of the combinatorial chemical library synthesis with EC(50)s between 10 and 100 microM. (nih.gov)
- 16. Investigation of solid-phase peptide synthesis by the near-infrared multispectral imaging technique: a detection method for combinatorial chemistry. (nih.gov)
- Details on the range of equipment available for medicinal and process chemistry as well as library synthesis applications are available on the company web pages ( www.anton-paar.com , www.biotage.com , www.cem.com , www.milestonesci.com ). (ddw-online.com)
- Synthesis of carbohydrate derivatives using solid-phase work-up and scavenging techniques. (ox.ac.uk)
Current Bioinformatics1
- Finally, a discussion by example presents the most current bioinformatics tools and analytical techniques. (pdf-drive.com)
Libraries4
- Our group previously developed reduction and photoresponsive combinatorial libraries of lipidoid nanoparticles for small molecule and biologics delivery. (nih.gov)
- Combinatorial chemistry, the preparation of large diverse libraries of new compounds from defined building blocks, is such a potentially powerful technique that it has had multiple lives. (nature.com)
- At the heart of dynamic combinatorial chemistry are the reversible reactions that enable the exchange of building blocks between library members in dynamic combinatorial libraries (DCLs) ensuring thermodynamic control over the system. (ku.dk)
- In this contribution, we show how disulfide exchange and boronic ester transesterification can function simultaneous in dynamic combinatorial libraries under appropriate conditions. (ku.dk)
Algorithms2
- His research involves development of quantum computing algorithms, error correction/mitigation techniques, and numerical simulator of quantum systems using high-performance computing on next-generation high-performance supercomputers. (anl.gov)
- The recent projects include development of quantum chemistry and combinatorial optimization quantum algorithms for NISQ quantum computers. (anl.gov)
Assays2
- In Steroid Receptor Methods: Protocols and Assays, a distinguished team of principal investigators and their associates describe in step-by-step detail a cross-section of the latest research techniques available for studying the endocrine system. (pdf-drive.com)
- Other protocols allow the reader to experiment with DNA-binding characteristics and hormone-binding assays and with the use of combinatorial chemistry for drug discovery. (pdf-drive.com)
Approaches2
- A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications. (mdpi.com)
- Figure 1: Contemporary approaches to combinatorial chemistry. (nature.com)
Biology3
- Chemistry and biology are traditionally taught as separate subjects at the high school level, where students memorize fundamental scientific principles that are universally accepted. (kyoto-u.ac.jp)
- The goal of this course is to develop skills for generating new ideas at the interface between chemistry and biology by analyzing pioneering studies. (kyoto-u.ac.jp)
- Inglese also serves as a scientific advisor to NIH-funded chemistry and screening centers, disease foundations, and international chemical biology consortia. (nih.gov)
Organic chemistry2
- Fundamental Chemistry for Pharmaceutics, composed of inorganic chemistry, organic chemistry and physical chemistry, is a basic course for all chemistry as well as an important basics for pharmacy courses. (must.edu.mo)
- Inglese received his Ph.D. in organic chemistry from Pennsylvania State University, under the guidance of chemist and enzymologist Stephen J. Benkovic, Ph.D., where Inglese studied tetrahydrofolate-dependent purine biosynthetic enzymes as new anticancer targets. (nih.gov)
Analytical techniques1
- We describe the detailed studies necessary to establish suitable reaction conditions and highlight the analytical techniques appropriate to study this type of system. (ku.dk)
Combichem1
- As a consequence, bottle-necks occur when the lead-compounds need to be produced on a large scale, for which the techniques of combichem are inappropriate. (ukri.org)
Library1
- If more than one reversible reaction operates in a single dynamic combinatorial library, the complexity of the system increases dramatically, and so does its possible applications. (ku.dk)
Physics1
- The ALCF is accelerating scientific discoveries in many disciplines, ranging from chemistry and engineering to physics and materials science. (anl.gov)
Numerical1
- As P.I: 'Numerical techniques for simulations of thin film spreading by surfactant', funded by Higher Education Commission of Pakistan. (edu.pk)
Technology2
- Solvay Pharmaceuticals is using ArQule's combinatorial chemistry technology in two important ways. (solvaypharmaceuticals.com)
- With in-depth knowledge of drug delivery theory and advanced ionic liquid technology, Alfa chemistry has the ability to provide effective solutions to a variety of problems encountered in the application of ionic liquids in drug delivery, thus contributing to the development of the medical industry and human health. (alfa-chemistry.com)
Compounds1
- Combinatorial chemistry has resulted in the more rapid discovery of lead-compounds in the pharmaceutical and agrochemical areas. (ukri.org)
Development1
- The past decade has seen the development of microwave equipment tailored specifically for chemistry, based on batch and flow processes. (ddw-online.com)
Data1
- Increasing the voltage applied to combinatorial chemistry and NMR data collection. (mainraum-gruenderhaus.de)
Research1
- NIH research has enabled new techniques to prevent heart attacks, newer and more effective drugs for lowering cholesterol and controlling blood pressure, and innovative strategies for dissolving blood clots and preventing strokes. (nih.gov)
Interest1
- Therefore, a great deal of interest has been forwarded to the salt formation technique to overcome solubility limitations. (aston.ac.uk)
Human1
- Those will help the students to understand experimental techniques of the human structure, anatomy and physiology. (must.edu.mo)
Preparation1
- Methods to allow the clean preparation of oligosaccharides were investigated using techniques that do not require conventional column chromatography or an aqueous work-up. (ox.ac.uk)
Discovery1
- Dynamic combinatorial chemistry has emerged as a promising tool for the discovery of complex receptors in supramolecular chemistry. (ku.dk)
Single1
- This article reviews key techniques and workflows, including the use of single- and multiple lectin columns and glycan detection by lectins. (eurekaselect.com)
Methods1
- HN - 2011 MH - Abdominal Wound Closure Techniques UI - D058107 MN - E4.987.100 MS - Methods to repair breaks in abdominal tissues caused by trauma or to close surgical incisions during abdominal surgery. (nih.gov)
Studies2
- Many clinical biomarkers are glycoproteins and glycoproteomic studies that use lectin affinity techniques have been shown to have a superior ability to determine structure-specific biomarkers of disease. (eurekaselect.com)
- Softer ionisation techniques are addressed rimadyl and case studies in impurity identification and quantitative analysis of the batch. (mainraum-gruenderhaus.de)
Technologies1
- Alfa Chemistry believes that partnerships will change the way the world innovates, bringing new technologies. (alfa-chemistry.com)
Group1
- Dr. Alexeev received his PhD in Physical Chemistry from Iowa State University while a graduate student in Mark Gordon's quantum chemistry group. (anl.gov)
Physical1
- Dr. Collins received a B.S. in chemistry from the University of Virginia, a Ph.D. in physical chemistry from Yale University, and an M.D. with honors from the University of North Carolina at Chapel Hill. (nih.gov)
Analysis1
- Critical Analysis of the Current Medical Image-Based Processing Techniques for Automatic Disease Evaluation: Systematic Literature Review. (cdc.gov)
Basic1
- Fundamental Chemistry - Laboratory is one of the most basic experimental courses of pharmacy. (must.edu.mo)
Multiple1
- Evaluation of Disability Progression in Multiple Sclerosis via Magnetic-Resonance-Based Deep Learning Techniques. (cdc.gov)
Effective1
- Therefore, green techniques are required for the effective delivery of poorly water-soluble drugs. (alfa-chemistry.com)
