Combinatorial Chemistry Techniques: A technology, in which sets of reactions for solution or solid-phase synthesis, is used to create molecular libraries for analysis of compounds on a large scale.Chemistry Techniques, Synthetic: Methods used for the chemical synthesis of compounds. Included under this heading are laboratory methods used to synthesize a variety of chemicals and drugs.Phosphinic Acids: Inorganic or organic derivatives of phosphinic acid, H2PO(OH). They include phosphinates and phosphinic acid esters.Peptide Library: A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide.Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Chemistry Techniques, Analytical: Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Structure-Activity Relationship: The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.Click Chemistry: Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.Optical Fibers: Thin strands of transparent material, usually glass, that are used for transmitting light waves over long distances.Light: That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.Trigeminal Nucleus, Spinal: Nucleus of the spinal tract of the trigeminal nerve. It is divided cytoarchitectonically into three parts: oralis, caudalis (TRIGEMINAL CAUDAL NUCLEUS), and interpolaris.Fiber Optic Technology: The technology of transmitting light over long distances through strands of glass or other transparent material.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Calorimetry, Differential Scanning: Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.Drug Repositioning: The deliberate and methodical practice of finding new applications for existing drugs.Oligosaccharides: Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.Carbohydrates: The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.Carbohydrate Sequence: The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.Carbohydrate Conformation: The characteristic 3-dimensional shape of a carbohydrate.Carbohydrate Metabolism: Cellular processes in biosynthesis (anabolism) and degradation (catabolism) of CARBOHYDRATES.Pain Clinics: Facilities providing diagnostic, therapeutic, and palliative services for patients with severe chronic pain. These may be free-standing clinics or hospital-based and serve ambulatory or inpatient populations. The approach is usually multidisciplinary. These clinics are often referred to as "acute pain services". (From Br Med Bull 1991 Jul;47(3):762-85)Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.Protein Engineering: Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.Computer-Aided Design: The use of computers for designing and/or manufacturing of anything, including drugs, surgical procedures, orthotics, and prosthetics.Drug Discovery: The process of finding chemicals for potential therapeutic use.Tissue Engineering: Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.Silk: A continuous protein fiber consisting primarily of FIBROINS. It is synthesized by a variety of INSECTS and ARACHNIDS.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)DirectoryPeriodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Location Directories and Signs: Directory signs or listings of designated areas within or without a facility.Solutions: The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Micro-Electrical-Mechanical Systems: A class of devices combining electrical and mechanical components that have at least one of the dimensions in the micrometer range (between 1 micron and 1 millimeter). They include sensors, actuators, microducts, and micropumps.Equipment Design: Methods of creating machines and devices.Biomimetics: An interdisciplinary field in materials science, ENGINEERING, and BIOLOGY, studying the use of biological principles for synthesis or fabrication of BIOMIMETIC MATERIALS.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Intellectual Property: Property, such as patents, trademarks, and copyright, that results from creative effort. The Patent and Copyright Clause (Art. 1, Sec. 8, cl. 8) of the United States Constitution provides for promoting the progress of science and useful arts by securing for limited times to authors and inventors, the exclusive right to their respective writings and discoveries. (From Black's Law Dictionary, 5th ed, p1014)Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Monte Carlo Method: In statistics, a technique for numerically approximating the solution of a mathematical problem by studying the distribution of some random variable, often generated by a computer. The name alludes to the randomness characteristic of the games of chance played at the gambling casinos in Monte Carlo. (From Random House Unabridged Dictionary, 2d ed, 1993)Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Trichosanthes: A plant species of the family CUCURBITACEAE that is a source of TRICHOSANTHIN (a ribosomal inhibitory protein).Software: Sequential operating programs and data which instruct the functioning of a digital computer.Stochastic Processes: Processes that incorporate some element of randomness, used particularly to refer to a time series of random variables.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Electrophoresis, Microchip: A highly miniaturized version of ELECTROPHORESIS performed in a microfluidic device.Spectrometry, Mass, Electrospray Ionization: A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.Microfluidic Analytical Techniques: Methods utilizing the principles of MICROFLUIDICS for sample handling, reagent mixing, and separation and detection of specific components in fluids.Chromatography, Liquid: Chromatographic techniques in which the mobile phase is a liquid.Electrophoresis, Capillary: A highly-sensitive (in the picomolar range, which is 10,000-fold more sensitive than conventional electrophoresis) and efficient technique that allows separation of PROTEINS; NUCLEIC ACIDS; and CARBOHYDRATES. (Segen, Dictionary of Modern Medicine, 1992)

A multiplasmid approach to preparing large libraries of polyketides. (1/942)

A three-plasmid system for heterologous expression of 6-deoxyerythronolide B synthase (DEBS) has been developed to facilitate combinatorial biosynthesis of polyketides made by type I modular polyketide synthases (PKSs). The eryA PKS genes encoding the three DEBS subunits were individually cloned into three compatible Streptomyces vectors carrying mutually selectable antibiotic resistance markers. A strain of Streptomyces lividans transformed with all three plasmids produced 6-deoxyerythronolide B at a level similar to that of a strain transformed with a single plasmid containing all three genes. The utility of this system in combinatorial biosynthesis was demonstrated through production of a library of modified polyketide macrolactones by using versions of each plasmid constructed to contain defined mutations. Combinations of these vector sets were introduced into S. lividans, resulting in strains producing a wide range of 6-deoxyerythronolide B analogs. This method can be extended to any modular PKS and has the potential to produce thousands of novel natural products, including ones derived from further modification of the PKS products by tailoring enzymes.  (+info)

Modelling G-protein-coupled receptors for drug design. (2/942)

The G-protein coupled receptors form a large and diverse multi-gene superfamily with many important physiological functions. As such, they have become important targets in pharmaceutical research. Molecular modelling and site-directed mutagenesis have played an important role in our increasing understanding of the structural basis of drug action at these receptors. Aspects of this understanding, how these techniques can be used within a drug-design programme, and remaining challenges for the future are reviewed.  (+info)

A combinatorial approach to producing sterically stabilized (Stealth) immunoliposomal drugs. (3/942)

We have developed a method for producing sterically stabilized immunoliposomal drugs (SIL) readily applicable to a 'mix and match' combinatorial approach for the simple manufacture of a variety of ligand-targeted liposomal drugs. Ligands coupled to the terminus of polyethylene glycol (PEG) in micelles formed from PEG-lipid derivatives (mPEG2000-DSPE) could be transferred into preformed, drug-containing liposomes from the micelles in a temperature- and time-dependent manner. Antibody densities up to 100 microg antibody/micromol of phospholipid, and up to 3 mol% of mPEG2000-DSPE, could be simultaneously transferred from the ligand-coupled micelles into the liposomal outer monolayer with negligible drug leakage from liposomes during transfer and good stability in human plasma. Transfer of anti-CD19 into SIL resulted in a three-fold increase in binding of these liposomes to CD19+ human B cell lymphoma cells.  (+info)

Phagotopes derived by antibody screening of phage-displayed random peptide libraries vary in immunoreactivity: studies using an exemplary monoclonal antibody, CII-C1, to type II collagen. (4/942)

Antibody screening of phage-displayed random peptide libraries to identify mimotopes of conformational epitopes is promising. However, because interpretations can be difficult, an exemplary system has been used in the present study to investigate whether variation in the peptide sequences of selected phagotopes corresponded with variation in immunoreactivity. The phagotopes, derived using a well-characterized monoclonal antibody, CII-C1, to a known conformational epitope on type II collagen, C1, were tested by direct and inhibition ELISA for reactivity with CII-C1. A multiple sequence alignment algorithm, PILEUP, was used to sort the peptides expressed by the phagotopes into clusters. A model was prepared of the C1 epitope on type II collagen. The 12 selected phagotopes reacted with CII-C1 by both direct ELISA (titres from < 100-11 200) and inhibition ELISA (20-100% inhibition); the reactivity varied according to the peptide sequence and assay format. The differences in reactivity between the phagotopes were mostly in accord with the alignment, by PILEUP, of the peptide sequences. The finding that the phagotopes functionally mimicked the C1 epitope on collagen was validated in that amino acids RRL at the amino terminal of many of the peptides were topographically demonstrable on the model of the C1 epitope. Notably, one phagotope that expressed the widely divergent peptide C-IAPKRHNSA-C also mimicked the C1 epitope, as judged by reactivity in each of the assays used: these included cross-inhibition of CII-C1 reactivity with each of the other phagotopes and inhibition by a synthetic peptide corresponding to that expressed by the most frequently selected phagotope, RRLPFGSQM. Thus, it has been demonstrated that multiple phage-displayed peptides can mimic the same epitope and that observed immunoreactivity of selected phagotopes with the selecting mAb can depend on the primary sequence of the expressed peptide and also on the assay format used.  (+info)

Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides. (5/942)

Signalling by fibroblast growth factors (FGFs) through FGF receptors (FGFRs) depends on the cell-surface polysaccharide heparan sulphate (HS) [1] [2]. HS has an ordered domain structure of highly diverse saccharide motifs that present unique displays of sulphate, carboxyl and hydroxyl groups [3]. These motifs interact with many proteins, particularly growth factors. HS binds both to FGFs [4] [5] [6] and FGFRs [7], and probably activates signalling by facilitating ligand-induced receptor dimerisation [8] [9]. Nevertheless, the extent to which specific HS saccharide sequences play a regulatory role has not been established. By screening a library of structurally diverse HS decasaccharides in bioassays of FGF signalling mediated by three different FGFR isoforms, we found that saccharides showed specificity for both ligands and receptors; some saccharides selectively activated FGF signalling through different FGFR isoforms, others acted as negative regulators. We conclude that HS saccharides play critical roles in dictating the specificity of ligand-receptor interactions in FGFR signalling. Controlled alterations in HS structures [10] would provide a mechanism for regulation of cellular responsiveness to growth factors that bind HS.  (+info)

Combinatorial catalysis: identification of potent chiral catalysts through fluorescent bead signaling. (6/942)

Simultaneous labeling of beads with a fluorescent sensor and a unique catalyst allows chemists to identify the most active catalyst within a mixture. This approach is a valuable addition to the protocols available in the growing field of combinatorial catalysis.  (+info)

A loop-mimetic inhibitor of the HCV-NS3 protease derived from a minibody. (7/942)

We have been interested for some time in establishing a strategy for deriving lead compounds from macromolecule ligands such as minibody variants. A minibody is a minimized antibody variable domain whose two loops are amenable to combinatorial mutagenesis. This approach can be especially useful when dealing with 'difficult' targets. One such target is the NS3 protease of hepatitis C virus (HCV), a human pathogen that is believed to infect about 100 million individuals worldwide and for which an effective therapy is not yet available. Based on known inhibitor specificity (residues P6-P1) of NS3 protease, we screened a number of minibodies from our collection and we were able to identify a competitive inhibitor of this enzyme. We thus validated an aspect of recognition by HCV NS3 protease, namely that an acid anchor is necessary for inhibitor activity. In addition, the characterization of the minibody inhibitor led to the synthesis of a constrained hexapeptide mimicking the bioactive loop of the parent macromolecule. The cyclic peptide is a lead compound prone to rapid optimization through solid phase combinatorial chemistry. We therefore confirmed that the potential of turning a protein ligand into a low molecular weight active compound for lead discovery is achievable and can complement more traditional drug discovery approaches.  (+info)

Oligonucleotide-conjugated beads for transdominant genetic experiments. (8/942)

Transdominant genetics using expression libraries can identify proteins and peptides that affect cell division. In conjunction with these libraries, oligo-nucleotide-conjugated beads and flow cytometry were used to test a strategy that potentially expands the range of such genetic studies. The experimental approach involved creation of tagged expression libraries, introduction of these libraries into cells, growth of the cultured cells for several generations and recovery on oligonucleotide-conjugated beads of sequences that encode growth-modulatory proteins or peptides. Experiments in Saccharomyces cerevisiae demonstrating the feasibility of the strategy are presented.  (+info)

387501517 - EP 0983983 A3 2000-07-05 - Combinatorial synthesis and analysis of organometallic compounds and catalysts - [origin: EP0978499A2] Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be applied to the preparation and screening of large numbers of organometallic compounds which can be used not only as catalysts (eg homogeneous catalysts), but also as additives and therapeutic agents.[origin: EP0978499A2] Methodologies for the synthesis, screening and characterisation of organometallic compounds and catalysts (eg homogenous catalysts), including combinatorial synthesis, screening and characterisation of libraries of supported and unsupported organometallic compounds and catalysts (eg homogenous catalysts). The methods can be
Dynamic combinatorial chemistry utilises reversible reactions to set up a dynamic library of molecules, with the library composition determined by the thermodynamic stability of each library member. Upon addition of a protein template, any library members which bind to the template are stabilised and amplified. Analysis of the library composition enables the identification of molecules which bind to the template protein. The suitability of two enzyme catalysed reactions catalysed by N-acetylneuraminic acid aldolase and subtilisin® Carlsberg was investigated for use in the synthesis of a DCL. A 173 component dynamic combinatorial library was successfully synthesised using these reactions with the resulting library screened against two protein template molecules, wheat germ agglutinin and Div1B. Several methods were investigated for the simplification of DCL analysis including the immobilisation of protein template molecules and the segregation of DCL proteins using semi-permiable membranes, ...
Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews dealing with various topics related to chemical biology (High Throughput Screening, Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research.
Since oxidative cellular damage contributes to the development of cancers, heart disease and ageing, the synthesis of antioxidative agents which are able to either prevent or mitigate oxidative stress to cells is an important area of investigation. Combinatorial chemistry has had a profound impact on the discovery and optimisation of potential lead compounds, especially in the medicinal field. This review details recent examples of combinatorial chemistry dealing with the synthesis of novel antioxidants with an emphasis on solid phase compound synthesis and parallel library synthesis.. Full text not available from this repository.. ...
Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews dealing with various topic...
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Bentham Science Publishers would like to invite you to submit your research paper for publishing in the Journal of Combinatorial Chemistr ...
The goal of this thesis was to develop a method for efficiently synthesizing a large suite of asymmetric oligoester ion channel-forming compounds. A solid-phase organic synthesis (SPOS) approach on Wang resin was used to generate the ion channel candidates. A follow-on goal is to survey the compounds produced to uncover structure-related controls on ion transport activity. Two classes of building blocks were used to generate the oligoesters - head groups and cores. The core building blocks were three omega-hydroxy acid derivatives six, eight and twelve carbons in length and the alcohol protected as a tetrahydropyranyl ether. The head group building blocks were either a glutaric acid monoester derivative of varying lipophilicity (12 to 16 carbon long alkyl tail) or a beta-hydroxy acid derivative; these building blocks used a tert-butyldimethylsilyl ether for alcohol protection. Optimized conditions for building block coupling, deprotection, and product cleavage were first established by the ...
Establishing synthesis methods for a target material constitutes a grand challenge in materials research, which is compounded with use-inspired specifications on the format of the material. Solar photochemistry using thin film materials is a promising technology for which many complex materials are being proposed, and the present work describes application of combinatorial methods to explore the synthesis of predicted La-Bi-Cu oxysulfide photocathodes, in particular alloys of LaCuOS and BiCuOS. The variation in concentration of three cations and two anions in thin film materials, and crystallization thereof, is achieved by a combination of reactive sputtering and thermal processes including reactive annealing and rapid thermal processing. Composition and structural characterization establish composition-processing-structure relationships that highlight the breadth of processing conditions required for synthesis of LaCuOS and BiCuOS. The relative irreducibility of La oxides and limited diffusion ...
TentaGel® Macrobeads are highlighted by extraordinary large particle diameters and high capacities based on the TentaGel® technology and designed for single bead synthesis and single bead analysis ...
Multicomponent reactions are flexible reactions for the rapid generation of complex molecules with often biologically relevant scaffold structures. Combined with the ease of parallelization and the exploratory power with regard to chemical space, multicomponent reactions have attracted significant attention
International Scholarly Research Notices is a peer-reviewed, Open Access journal covering a wide range of subjects in science, technology, and medicine. The journals Editorial Board as well as its Table of Contents are divided into 108 subject areas that are covered within the journals scope.
The designing, synthesizing and screening of one-bead-one-compound (OBOC) combinatorial chemistry libraries against a single target ligand has been well developed. Recently, novel cholesterol/peptide hybrid combinatorial One-Bead-One-Compound (OBOC) combinatorial libraries have been developed and synthesized with self folding capabilities. The library design strategy was based on a similar pentamer and hexamer self-folding branched tricylic libraries previously developed. The cholic acid on the side chain of the carboxyl lysine is believed to interact with fixed hydrophobic amino acids at the amino-termini (position 5) of the twin branched L-amino acid arms and self-fold into a tricyclic molecule. The newly synthesized library has arginine (R) and Lysine (K) down-proportioned to 10 % for each position to decrease the probability of positive charge nonspecific binding. Thirty L-, D-, and unnatural amino acids were used in each position as building blocks. Hydrophobicity was fixed at position 5 ...
An apparatus for high-throughput combinatorial syntheses of organic molecules including a reaction vessel for containing a combinatorial-chemistry synthetic reaction, a liquid dispenser for dispensing the liquid, a liquid aspirator and an adjustment mechanism. The reaction vessel includes an ingress aperture allowing a liquid to enter into an interior of the vessel and an egress aperture for aspirating the liquid from the vessel. The liquid dispenser dispenses liquid through the ingress aperture. The liquid aspirator aspirates liquid through the egress aperture and includes a rotor for carrying the vessel and orbiting the vessel about an axis of rotation. The rotor is oriented generally in a horizontal plane and includes an adjustment mechanism for adjusting the angle of the vessel relative to the horizontal plane in response to the centrifugal force generated by orbiting the vessel about the axis of rotation. A method of combinatorial synthesis of organic molecules is also disclosed.
Systems and methods for providing in situ, controllably variable concentrations of one, two or more chemical components on a substrate to produce an integrated materials chip. The component concentrations can vary linearly, quadratically or according to any other reasonable power law with one or two location coordinates. In one embodiment, a source and a mask with fixed or varying aperture widths and fixed or varying aperture spacings are used to produce the desired concentration envelope. In another embodiment, a mask with one or more movable apertures or openings provides a chemical component flux that varies with location on the substrate, in one or two dimensions. In another embodiment, flow of the chemical components through nuzzle slits provides the desired concentrations. An ion beam source, a sputtering source, a laser ablation source, a molecular beam source, a chemical vapor deposition source and/or an evaporative source can provide the chemical component(s) to be deposited on the substrate.
Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.: A phenotypic high-throughput screen using ∼100,000 compounds prepared usin
N-Acylsulfonamides usually react with nucleophiles by acyl transfer and C-N bond fission. However, the hydrolysis of N-acyl -sultams is a sulfonyl transfer reaction that occurs with S-N fission and opening of the four-membered ring. Similar to other -sultams, the N-acyl derivatives are at least 106-fold more reactive than N-acyl sulfonamides. 3-Oxo--sultams are both -lactams and -sultams but also hydrolyze with preferential S-N bond fission.. ...
TentaGel® resins are grafted copolymers consisting of a low crosslinked polystyrene matrix on which polyethylene glycol (PEG or POE) is grafted. The PEG spacer is attached to the matrix via an ethyl ether group which increases stability towards acid treatment and minimizes PEG-leaching. As PEG is a chameleon type polymer with hydrophobic and hydrophilic properties, the graft copolymer shows modified physico chemical properties which are highly dominated by the PEG moiety (and no longer by the polystyrene matrix). These graft copolymers are pressure stable and can be used in batch processes as well as under continuous flow conditions. The PEG spacer is in the range of MW 3000 Da. This resin is synthesized from TentaGel® amine and the base labile 4-(hydroxymethyl)benzoic acid linker. It is a versatile support for the immobilization of carboxylic acids. The resulting ester bond is stable to strong acids but is cleaved by nucleophiles like amines, hydrazine or alkoxides. ...
Isogenica, Cambridge UK and Imperial College London secure funding from UKs Technology Strategy Board to develop gene library synthesis for synthetic
AIM AND OBJECTIVE: The importance of acridine core structure and other heterocycles containing its framework is well known, as they are found in numerous compounds with a variety of biological effects. Pyridine is also an important solvent and heterocyclic nucleus for the design and synthesis of novel molecules with biological properties. It occurs in several natural compounds which are used as a precursor in agrochemicals and pharmaceuticals. The utility of nanostructured metal salts because of their small size and high surface area as catalysts in organic synthesis has drawn special attention due to their better properties such as slower reaction rate, reusability of the catalyst, and higher yields of products compared to the bulk size ...
Bentham Science Publishers would like to invite you to submit your research paper for publishing in the Journal of Combinatorial Chemistr ...
PharmaSeq, Inc., is a private company located near Princeton, NJ. Its business is in developing an ultra-small microtransponder tagging platform that has broad applications for the tagging and tracking of objects used in the consumer goods, industrial goods, life sciences and eventually clinical diagnostics industries.
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A versatile copper(i)-catalyzed cascade multicomponent reaction strategy between readily available (Z)-3-iodoacrylic acids, terminal alkynes, and primary amines is reported, leading to a great diversity of complex heterocyclic backbones based on biorelevant indole/lactam scaffolds.
The use of cyclic peptides in one-bead-one-compound libraries is limited by difficulties in sequencing hit compounds. Lacking a free N-terminal amine, such peptides cannot be sequenced by the Edman degradation approach, and complex fragmentation patterns are obtained by tandem mass spectrometry. To overcome this problem, we designed an alternative approach introducing a methionine residue within the macrocycle and as a linker to allow simultaneous ring-opening and release from the resin upon treatment with cyanogen bromide. The methionine linker was inverted relative to the peptide chain to allow the synthesis of cyclic peptides anchored by a lysine side chain and to avoid the presence of two C-terminal homoserine lactones on the released linear peptides. After MALDI-TOF MS/MS analysis, the peptides released from a single bead were sequenced manually and with a de novo sequencing software. The strategy described herein is compatible with commonly used amino acids and allows sequencing of cyclic ...
Dynamic covalent chemistry (DCvC) is a synthetic strategy employed by chemists to make complex supramolecular assemblies from discrete molecular building blocks. DCvC has allowed access to complex assemblies such as covalent organic frameworks, molecular knots, polymers, and novel macrocycles. Not to be confused with dynamic combinatorial chemistry, DCvC concerns only covalent bonding interactions. As such, it only encompasses a subset of supramolecular chemistries. The underlying idea is that rapid equilibration allows the coexistence of a variety of different species among which molecules can be selected with desired chemical, pharmaceutical and biological properties. For instance, the addition of a proper template will shift the equilibrium toward the component that forms the complex of higher stability (thermodynamic template effect). After the new equilibrium is established, the reaction conditions are modified to stop equilibration. The optimal binder for the template is then extracted ...
Related Articles. Structure-Based Design of Inhibitors of the Aspartic Protease Endothiapepsin by Exploiting Dynamic Combinatorial Chemistry.. Angew Chem Int Ed Engl. 2014 Feb 14 ...
The blood-brain barrier (BBB) is a biological barrier that protects the brain from neurotoxic agents and regulates the influx and efflux of molecules required for its correct function. This stringent regulation hampers the passage of brain parenchyma-targeting drugs across the BBB. BBB shuttles have been proposed as a way to overcome this hurdle because these peptides can not only cross the BBB but also carry molecules which would otherwise be unable to cross the barrier unaided. Here we developed a new high-throughput screening methodology to identify new peptide BBB shuttles in a broadly unexplored chemical space. By introducing d-amino acids, this approach screens only protease-resistant peptides. This methodology combines combinatorial chemistry for peptide library synthesis, in vitro models mimicking the BBB for library evaluation and state-of-the-art mass spectrometry techniques to identify those peptides able to cross the in vitro assays. BBB shuttle synthesis was performed by the ...
SAN DIEGO-- Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) today announced that it has agreed to divest and sell its combinatorial chemical library and associated proprietary technology to Venenum Biodesign, LLC, an affiliate of Medical Diagnostic Laboratories, LLC, members of Genesis Biotechnology Group (GBG), for $1.8 million. Under the terms of the agreement, Ligand will receive $1 million at the close of the transaction, $800,000 over the next two years and 10% of all revenues from third party collaborations for three years. The combinatorial chemistry asset, which Ligand obtained in the acquisition of Pharmacopeia in December 2008, comprises an encoded combinatorial library collection (ECLiPS) and an ultra-high throughput screening platform. "While this screening technology was valuable in the discovery of multiple drug candidates for many of our existing collaborations, it is no longer required in the service of those collaborations and going forward it is not a priority for our ...
A novel and patented platform technology is being developed to create a new method ultimately capable of sequencing over four billion bases a day. The new method will be faster, more accurate and will inaugurate a paradigm shift in the analysis of genomic information. The method is based on the development of digital multibit encoding techniques that utilise advanced magnetic technology. The project has far reaching implications related to the development of advanced systems for ultra high throughput biological assays that can be used in clinical diagnostics, drug discovery and genome sequencing. The generic technology will be capable of tagging billions of compounds synthesised by combinatorial chemistry techniques and decode them in a single experiment. The main advantages of the proposed technology are, the ability to provide remote encoding during the synthesis of chemical or biological moieties, the ability to provide an extremely large number of discrete codes and the ability to rapidly ...
A new complementary approach is proposed to identify, characterize and integrate high temperature materials into harsh environment diagnostic systems. Program partner URI will sputter candidate conductive oxides with continuously varying levels of doping. Test specimens will be fabricated and systematically assessed using combinatorial synthesis to determine which exhibit the most favorable characteristics e.g., high temperature stability, consistency, sensitivity, for sensor use. MesoScribe Technologies will apply its Mesoplasma Direct Write process, a high-precision derivative of thermal spray technology, to deposit the selected materials in precise sensor architectures. URIs experience in material characterization and ceramic oxide strain gages will be combined with MesoScribes expertise in sensor design and fabrication to achieve application-specific measurement capability in high temperature (1600C) regime of gas turbines and hypersonic structures. BENEFIT: The capability to monitor the ...
DESCRIPTION (provided by applicant): The efficiency of high throughput screening can be improved if libraries with huge diversity could be characterized for bioactivity in preliminary rounds of screening. There are currently no instruments that can characterize the bioactivities of combinatorial libraries.Intelligent Optical Systems (lOS) proposes to develop a new, inexpensive, optical instrument, based on a label less detection principle, for the rapid characterization of the bioactivities of combinatorial libraries. The proposed instrument will have sensitivities comparable to surface plasmon resonance and will measure binding events in real time. The instrument will be able to distinguish high affinity specific interactions from low affinity nonspecific binding. The proposed device consists of a laser light source, a biochip, a flow cell, a pair of detectors, and a computer for analyzing the detectors output. In Phase I, lOS will demonstrate the feasibility of using this instrument as a tool ...
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Although therapeutically targeting a single signaling pathway that drives tumor development and/or progression has been effective for a number of cancers, in many cases this approach has not been successful. Targeting networks of signaling pathways, instead of isolated pathways, may overcome this problem, which is probably due to the extreme heterogeneity of human tumors. However, the possibility that such networks may be spatially arranged in specialized subcellular compartments is not often considered in pathway-oriented drug discovery and may influence the design of new agents. Hsp90 is a chaperone protein that controls the folding of proteins in multiple signaling networks that drive tumor development and progression. Here, we report the synthesis and properties of Gamitrinibs, a class of small molecules designed to selectively target Hsp90 in human tumor mitochondria. Gamitrinibs were shown to accumulate in the mitochondria of human tumor cell lines and to inhibit Hsp90 activity by acting as ATPase
801. RNA Gene Therapy Targeting Herpes Simplex Virus. Jia Liu; Tuli, Sonal S.; Bloom, David C.; Schultz, Gregory S.; Ghivizzani, Steve C.; Lewin, Alfred S. // Molecular Therapy;Jun2006, Vol. 13, pS310 Purpose: Herpes Simplex Keratitis (HSK) is the leading cause of corneal blindness in developed nations. Despite active antiviral drugs (nucleoside analogues), there is no effective method preventing recurrent HSK. We tested the ability of ribozymes targeting the mRNAs of essential HSV genes to... ...
Firstly, we built a DDI graph, of which nodes are drugs and edges are their interactions, then applied Flody algorithm [17] to calculate the shortest distance (steps in a graph) between two drugs. The results show that the majority (73.73%) of positive pairs contains the individual drug members apart from 2 steps, whereas only the minority (42.01%) of negative pairs contains the individual drug members apart from 2 steps. Then, we simply estimated the separability between positives and negatives by 0.7373/(0.7373 + 0.4201) =0.6370. In addition, no positive pair has the member drugs are , = 5 steps from each other and very few of positive pairs have the member drugs interacting with each other. This brings the first observation that two drugs do not tend to interact with each other but are usually close to each other in DDI graph if they are combinative. Thus, we used SVD to characterize the DDI graph and extracted the DDI-based feature vectors (see also Drug-drug interaction network).. Secondly, ...
Most security vulnerabilities arise from flaws in software implementation, and are difficult to discover because they are often triggered by rarely used parts of the code. Exhaustive testing is impossible for real-world software so high assurance software is tested using methods that require extensive staff time and thus have enormous cost. Most unit and system testing only
The goal of the course is to give basic theoretical knowledge in the area of medicinal chemistry. This includes knowledge in interactions between low molecular weight compounds and proteins, DNA, and RNA, and methods for identification, design, synthesis, and evaluation of drug candidates. After completion of the course the students shall be familiar with the processes involved in the development of a drug, have a detailed understanding of the concept of ligand-receptor interaction, possess basic knowledge in methods for medicinal and combinatorial chemistry, have a broad overview of drug uptake, metabolism, and secretion, and by oneself be able to retrieve chemical, biological, and medical information from databases ...
The future of medicinal chemistry as both a pure and an applied science has been considered relative to trends that are already having a significant impact upon drug discovery and development. Such trends include pursuing therapeutic efficacy, addressing 3-D structure within database settings, assuring absorption, directing distribution, controlling metabolism, optimizing elimination, and avoiding toxicity. As the exploration of these topics proceeds by deploying combinatorial chemistry coupled to high-throughput screening, medicinal chemistry will play a key role in interpreting the underlying structureactivity relationships. This will cause the overall process of drug discovery and development to be knowledge generating. As fundamental knowledge accumulates across all of these areas, virtual approaches will eventually become firmly anchored to experimental and theoretical databases having validated clinical predictability. ...
36. ChemScreener: A Distributed Computing Tool for Scaffold based Virtual Screening,Combinatorial chemistry & high throughput screening 18(6): 544 - 561 (2015)Muthukumarasamy Karthikeyan, Deepak Pandit and Renu Vyas. DOI: 10.2174/1386207318666150703112242. View Abstract ABSTRACT: In this work we present ChemScreener, a Java-based application to perform virtual library generation combined with virtual screening in a platform-independent distributed computing environment. ChemScreener comprises a scaffold identifier, a distinct scaffold extractor, an interactive virtual library generator as well as a virtual screening module for subsequently selecting putative bioactive molecules. The virtual libraries are annotated with chemophore-, pharmacophore- and toxicophore-based information for compound prioritization. The hits selected can then be further processed using QSAR, docking and other in-silico approaches which can all be interfaced within the ChemScreener framework. As a sample application, in ...
Received: October 27, 2003; Accepted for publication: February 20, 2004; Published on Web: May 10, 2004). In the domain of chemistry, many experimental data are being accumulated by combinatorial chemistry and high throughput screening (HTS) and so on. In order to obtain benefit information from these data, a lot of methodologies of chemometrics have been developed. Since usually these numerical data are represented as multi-dimensional arrays, traditional statistical software cannot handle these data directly. In this study, we developed data modeling software, which handles multi-dimensional arrays effectively. By using this software we are able to analyze multi-dimensional data. It is possible to understand the structure of multi-dimensional data by using graphical representation such as bar graph, line graph and so on. And the data modeling method, Multi-way PLS (partial least squares) and Kohonen neural network are available for the analysis of multi- dimensional data ...
Abstract :. In past decades, dynamic covalent chemistry has shown its great potential in the area of combinatorial chemistry and molecular recognition. Nonetheless, in this area, a few reactions have been explored that can allow selective recognition of endogenous nucleophile in reversible manner at physiological pH. Iminoboronate chemistry is one of them, which allow to capture amine at neutral pH. Here, I will present, how the fundamental understanding of iminoboronate complex formation was leveraged for numerous biological applications. Iminoboronate chemistry was known, however, it was poorly understood. For the first time, my work has revealed the dynamic nature of iminoboronate formation at physiological conditions.. In this talk, I will focus first on the dynamic covalent recognition of biologically important molecules via iminoboronate chemistry. Using this unique chemistry, I developed strategies for the specific recognition of gram-positive bacteria in blood serum [1]. Importantly, ...
Abstract :. In past decades, dynamic covalent chemistry has shown its great potential in the area of combinatorial chemistry and molecular recognition. Nonetheless, in this area, a few reactions have been explored that can allow selective recognition of endogenous nucleophile in reversible manner at physiological pH. Iminoboronate chemistry is one of them, which allow to capture amine at neutral pH. Here, I will present, how the fundamental understanding of iminoboronate complex formation was leveraged for numerous biological applications. Iminoboronate chemistry was known, however, it was poorly understood. For the first time, my work has revealed the dynamic nature of iminoboronate formation at physiological conditions.. In this talk, I will focus first on the dynamic covalent recognition of biologically important molecules via iminoboronate chemistry. Using this unique chemistry, I developed strategies for the specific recognition of gram-positive bacteria in blood serum [1]. Importantly, ...
ACB Blocks, Ontario, Canada - Modern drug discovery has gathered a substantial momentum in the past few years due to the impact of combinatorial chemistry - a discipline which enables to rapidly explore structure-activity relationships (SAR) while search.
In the mid‐ to late 1990s, because of the drug discovery paradigm shift from phenotypic screens to combinatorial chemistry and high‐throughput screening, the physicochemical properties of exploratory drug molecules displayed a dramatic shift toward higher molecular weight and lipophilicity
Darvas F, Marokházi S, Kormos P, Kulkarni G, Kalász H, Papp Á, "Metabolexpert: Its Use in Metabolism Research and in Combinatorial Chemistry, in Drug Metabolism, Databases and High-Throughput Testing During Drug Design and Development", Ed. by P.W. Erhardt, IUPAC, Toledo, Ohio, pp. 237-270 (1999 ...
Metabolexpert: Its Use in Metabolism Research and in Combinatorial Chemistry, in Drug Metabolism, Databases and High-Throughput Testing During Drug Design and Development", Darvas F, Marokházi S, Kormos P, Kulkarni G, Kalász H, Papp Á, Ed. by P.W. Erhardt, IUPAC, Toledo, Ohio, pp. 237-270 (1999). ...
An edited search engine for healthcare information on the Web. Unlike generic search engines, CiteLine doesnt aim to index the Web in its entirety, only sites of interest to professionals in the pharmaceutical and healthcare industries. Every topic from R&D combinatorial chemistry to medical economics is covered, with sites carefully screened by the subject specialists in our editorial team ...
Heterocyclic chemistry is the biggest branch of chemistry covering two-third of the chemical literature The series covers hot topics of frontier research
The application of grinding method in solid-phase organic synthesis has been developing rapidly in the past two or three decades. It is more
Combinatorial libraries that contains various different 4, 5 fused 3-substituted-2-pyrrolocarboxylic acids for screening pharmacological activity and methods of synthesizing said libraries.
In engineering protein variants by constructing and screening combinatorial libraries of chimeric proteins, two complementary and competing goals are desired: the new proteins must be similar enough t
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This course is a continuation of CHEMBIO 501. The basic concepts obtained in CHEMBIO 501 will be applied to and demonstrated in three broad areas of interest to both chemists and biologists. The first topic will discuss combinatorial methods including SELEX and gene shuffling, combinatorial organic synthesis, high throughput screening and chemical genetics. The second topic will focus on signal transduction, emphasizing general concepts (at the molecular level) and how small molecules have been used to probe and modulate signal transduction pathways. The final topic will cover protein translation, stressing mechanistic aspects of protein synthesis and folding in vivo.. ...
Parallel Synthesis reaction technology ✔ Replace the Round Bottom Flask ✔ Organic Synthesis on the 0.5mL to 100mL scale ✔ Temperature range: -40 °C to 180 °C ✔ Reaction Screening → Better Chemistry
After a chemical biologist has made many novel small molecules by diversity-oriented synthesis, the next step is to find those that are useful. Molecules need to be
(2R)-Bornane-10,2-sultam 94594-90-8 NMR spectrum, (2R)-Bornane-10,2-sultam H-NMR spectral analysis, (2R)-Bornane-10,2-sultam C-NMR spectral analysis ect.
During PACE, host E. coli cells flow continuously into a fixed-volume vessel (a lagoon) containing a population of filamentous bacteriophages that encode a library of evolving proteins. The lagoon is continuously drained to a waste container after passing through an in-line luminescence monitor that measures expression from a gene III-luciferase cassette on the AP. Dilution occurs faster than cell division but slower than phage replication. Each phage carries a protein-encoding gene to be evolved instead of a phage gene (gene III) that is required for infection. Phage encoding active library members trigger expression of gene III on the AP in proportion to the desired activity and consequently produce infectious progeny. Phage encoding less active library members produce fewer infectious progeny and are lost by dilution. From: Nat. Chem. Biol. 10, 216-222 (2014). PDF. ...
mSam He ■■■,:-m- ■£.£;*■■• ■.■.••■;.::. K ■ B Digitized by the Internet Archive in 2011 with funding from Boston Library Consortium Member Libraries http://www.archive.org/details/newtoncollege1972newt A" - ** - , & #, Do you ever wonder why you came to Newton? Do you ever wonder why you stayed? Perhaps we came here to learn everything - but slowly found that a good measurement of what we know is our realization of how much more there is to learn. We thought, worried, discussed - and sometimes just let ourselves be . . . and maybe that was most important. wuunmitf BFgaKB JgrnuyCTO iEcs uumauMir. Ltth^uaH gTHBiaTCi^SHagfigB^^ PA^PJ BPJ PJ , PPPPPPPPPPPl rear I «,ytv? H9BI rwE*^ za2£-.nPi ^^^p^pl ) Bj-lh MB IBLiLIt. ■■JKP* £,*. ^B P We came to learn - from books, teachers, classes but more than that . . . ... we came to discover ourselves, alone or with each other. And in the search we realized the part of ourselves that is our work and the part of our work ...
The present invention includes composition and methods for making and using a combinatorial library to identify modified thioptamers that bind to, and affect the immune response of a host animal, transcription factors such as IL-6, NF-KB, AP-1 and the like. Composition and methods are also provided for the treatment of viral infections, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.
Deschamps, J. D., Gautschi, J. T., Whitman, S., Johnson, T. A., Gassner, N. C., Crews, P., & Holman, T. R. (2007). Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg ...
Creative Biolabs has developed a variety of specific selection strategies for isolation of pH-sensitive scFv using our custom diverse libraries enriched in histidine.
Scientists at Rutgers and other universities build technology that could lead to rapid discovery of new medicines and biomarkers hidden in genomes
AMSBIO offers a wide range of protein such as total protein, cell lysates, recombinant proteins, purified natural proteins, and peptides.
SiliCycle MiniBlock Family consists of compact parallel reactors dedicated to chemists in pharmaceutical, academic, biopharma, petrochemical and polymer industries
Anonymous]. 2004. De novo proteins from designed combinatorial libraries.. Protein science : a publication of the Protein Society. 13(7):1711-23. ...
This focus review documents the developments in polymer synthesis that involve multicomponent reactions (MCRs) and related sequential reaction systems. Postpolymerization modification and step-growth polymerization reactions based on MCRs and sequential reactions such as the Kabachnik-Fields three-component reaction (KF-3CR) are described. Welcoming more participants in a polymer synthesis; recent years, multicomponent reactions (MCRs) have been gradually integrated into synthetic polymer chemistry, which led to a new synthetic toolbox for a range of interdisciplinary applications. In this focus review, this new trend in polymer chemistry has been summarized with including contributions from the author.
This paper reports the synthesis and screening of a combinatorial peptide library for new affinity ligands for glycosylated haemoglobin (HbA(1c)), which is an important indicator of diabetes control. The new ligands are suitable for large-scale synthesis and overcome the disadvantages of antibodies (unstable and expensive to produce etc.), while remaining as efficient as antibodies in binding to the analyte. The library consisted of 262 144 hexapeptides synthesised using the one-bead-one-compound technique. The hexapeptides attached onto beads were screened with glycosylated haemoglobin HbA(1c). The structures of the peptides exhibiting high affinity were characterised by Edman microsequencing. Computer modelling simulation of one of the lead sequences has shown that this class of ligand has a high affinity and specificity for glycosylated haemoglobin. (C) 1998 Elsevier Science S.A. All rights reserved.. ...
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International trade is stepping into the age of digitally enabled trade, driven by cross-border data flows and interoperability. Concerns for cybersecurity, privacy, and digital sovereignty have prompted the widespread implementation of trade policies regulating cross-border data flows. At present, there is a deficit of information characterizing such policies and analyzing their role in the global economy. We address this deficit through a quantitative analysis of trade in services that seeks both to categorize data-related trade policies and to evaluate the extent to which they are similar to other restrictive measures. We propose a mixture-based clustering pipeline to group trade restrictiveness data and a method for quantifying the difference between the cross-border data flow regulations and other traditional regulations. Our analysis reveals that a significant localization effect among data flow restrictions and that, while highly restrictive data flow policies generally do not overlap with other
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. ...
Perspectives, compilations, and reviews of modern drug discovery methods:. Bunin, B. A.; Bajorath, J.; Morales, G.; Siesel, B. Cheminformatics: Theory, Practice, and Products 2006, Springer-Verlag, manuscript in press, A summary of the theory and features of the available modern cheminformatics tools.. Bunin, B. A. Increasing the Efficiency of Small Molecule Drug Discovery (In response to an interview with Chris Lipinski on current challenges) Drug Discovery Today 2003, 8, 18, 823-826.. Bunin, B. A.; Dener, J. M.; Livingston, D. A. Application of Combinatorial and Parallel Synthesis to Medicinal Chemistry Annu. Rep. Med. Chem. 1999, 34, 267-286.. Bunin, B. A. The Combinatorial Index 1998, pp. 1-322, Academic Press, An exhaustive compilation on methods for the combinatorial synthesis of small molecules widely used by synthetic chemists.. Morales, G. A.; Bunin, B. A. Guest Editors, Comb. Chem. & HTS., 2004, 7, 5. 397-529. Morales, G. A.; Bunin, B. A. Editors, Methods Enzymol., 2003, 369, ...
The selection, acquisition, and use of high‐quality small molecule libraries for screening is an essential aspect of drug discovery and chemical biology programs
DNA-encoded chemical libraries (DEL) is a technology for the synthesis and screening on unprecedented scale of collections of small molecule compounds. DEL is used in medicinal chemistry to bridge the fields of combinatorial chemistry and molecular biology. The aim of DEL technology is to accelerate the drug discovery process and in particular early phase discovery activities such as target validation and hit identification. DEL technology involves the conjugation of chemical compounds or building blocks to short DNA fragments that serve as identification bar codes and in some cases also direct and control the chemical synthesis. The technique enables the mass creation and interrogation of libraries via affinity selection, typically on an immobilized protein target. A homogeneous method for screening DNA-encoded libraries has recently been developed which uses water-in-oil emulsion technology to isolate, count and identify individual ligand-target complexes in a single-tube approach. In contrast ...
Search for Identifying A Library Member By Means Of A Tag, Label, Or Other Readable Or Detectable Entity Associated With The Library Member (e.g., Decoding Process, Etc.) Patents and Patent Applications (Class 506/4) Filed with the USPTO
Combinatorial synthesis is an efficient tool that can be used to discover new materials. It allows one to systemically study a large number of materials simultaneously as their physical properties change with the varying chemical composition. Using this technique, we study various multifunctional electronic materials. Different designs of libraries, such as discrete libraries and composition spreads, are fabricated and characterized in order to rapidly map composition-structure-property relationships in a variety of systems. We have made gas sensor device libraries to optimize the performance of gas sensing materials. We have utilized the combinatorial pulsed laser deposition (PLD) flange for fabricating the discrete device library of doped SnO2 thin films. Several libraries were made with different amounts of dopants such as In2O3, WO3, ZnO, Pt, and Pd. After exposing the whole library to chloroform, formaldehyde, and benzene gases, the compositions most sensitive to these gases were found. We ...
The Group of Nanomaterials and Microsystems has established as its main research goal the synergy between basic research in Nanoscience and Nanotechnology with the technological development of new tools to prepare and characterize materials at the nanoscale. The GNaM is one of the few groups in Europe working in nanocalorimetry of low dimensional systems and in the combinatorial synthesis and characterization of thin layers prepared by physical vapour deposition (PVD). Our group has also a wide experience in the study of transformation kinetics associated to nucleation and growth processes. Simultaneously, the group has developed and patented a high throughput analysis methodology based on membrane-based microchips to the study of phase transformations in thin films. The innovative and efficient synergy between synthesis and thermal characterization tools has brought the GNaM to an international recognition in the area of Nanoscience and Nanotechnology. Our team is formed by Javier Rodr guez Viejo,
UOP LLC, a Honeywell Company, Ford Motor Company, and Striatus, Inc., collaborated with Professor Craig Jensen of the University of Hawaii and Professor Vidvuds Ozolins of University of California, Los Angeles on a multi-year cost-shared program to discover novel complex metal hydrides for hydrogen storage. This innovative program combined sophisticated molecular modeling with high throughput combinatorial experiments to maximize the probability of identifying commercially relevant, economical hydrogen storage materials with broad application. A set of tools was developed to pursue the medium throughput (MT) and high throughput (HT) combinatorial exploratory investigation of novel complex metal hydrides for hydrogen storage. The assay programs consisted of monitoring hydrogen evolution as a function of temperature. This project also incorporated theoretical methods to help select candidate materials families for testing. The Virtual High Throughput Screening served as a virtual laboratory, calculating
Autori: Oprea, Tudor I.; Zamora, Ismael; Ungell, Anna-Lena. Editorial: Journal of Combinatorial Chemistry, 4, p.258-266, 2002.. Rezumat:. ChemGPS, the chem. global positioning system, is a tool that combines rules (equiv. to dimensions) and objects (chem. structures) to provide a consistent chem. space map (Oprea, T. I.; Gottfries, J. J. Comb. Chem. 2001, 3, 157-166.). Rules included, initially, general properties such as size, lipophilicity, and hydrogen bond capacity, while objects include „satellites", intentionally placed outside the druglike space, as well as „core" objects, mostly orally available drugs. ChemGPS mols. (objects) were used in conjunction with the VolSurf (http://www.moldiscovery.com) descriptors (rules), which are relevant for ADME (absorption, distribution, metab., and excretion) properties. The combination of ChemGPS and VolSurf, GPSVS, was investigated with respect to the biopharmaceutics classification system, which is recommended by the Food and Drug Administration ...
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Autor: Müller, Oliver et al.; Genre: Zeitschriftenartikel; Im Druck veröffentlicht: 2004; Keywords: bioorganic chemistry • combinatorial chemistry • library screening • medicinal chemistry • signal transduction; Titel: Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening
... , title = "Optimisation of Polystyrene Resin-supported Pt Catalysts in Room Temperature, Solvent-less, Oct-l-ene Hydrosilylation using Methyldichlorosilane", journal = "Combinatorial Chemistry & High Throughput Screening", parent_itemid = "infobike://ben/cchts", publishercode ="ben", year = "2002", volume = "5", number = "3", publication date ="2002-05-01T00:00:00", pages = "201-209", itemtype = "ARTICLE", issn = "1386-2073", url = "https://www.ingentaconnect.com/content/ben/cchts/2002/00000005/00000003/art00003", doi = "doi:10.2174/1386207024607293", keyword = "pt catalyst, solid phase peptide synthesis, solid support, polystyrene resin-support", author = "Drake, R. and Dunn, R. and Sherrington, D.C. and Thomson, S.J.", abstract = "Six precursor resins with systematic variation of porous parameters were prepared by suspension polymerisation using specific compositions of divinylbenzene, styrene vinylbenzyl chloride (VBC) and 2- ethylhexan-l-ol (a porogen). ...
I think that the reason for this lack of interest in solubility measurements relates to the way synthetic organic chemists have learned to think about their workflows. Generally, the researcher sets up an experiment with the intention of preparing and isolating a specific compound. The role of the solvent is usually just to solubilize the reactants - it is then commonly evaporated for chromatographic purification of the product. Even in combinatorial chemistry experiments where products are not purified for a rough screening, the expectation is that compounds of interest will be purified and characterized at some point ...
Location: Montr al, Quebec, Canada. Daniel Chelsky, PhD, is the chief scientific officer at Caprion, a company using mass spectrometry and multiparametric flow cytometry to discover and validate biomarkers of disease and drug efficacy, drug mechanism of action and new targets for disease intervention. Previously he served as president of BioSignal, Inc., a subsidiary of PerkinElmer focused on G-protein coupled receptor related research and reagents.. He has also held positions as senior director of biology at Pharmacopeia, a combinatorial chemistry company, director of drug discovery at Onyx Pharmaceuticals, and principal investigator at DuPont Merck Pharmaceuticals. He received his PhD at the University of Oregon and was an American Cancer Society fellow at the University of California, Berkeley.. ...
A variety of proven techniques, such as filtration, dialysis, liquid/liquid extraction and Solid Phase Extraction (SPE), are routinely adopted in todaylj analytical laboratories to resolve the vast array of sample preparation demands. SPE has established itself as one of the most popular and flexible tools within the analytical laboratory; providing effective, efficient sample concentration and purification prior to HPLC, LC/MS, GC or GC/MS and adaptation to automated techniques such as combinatory chemistry. The resultant SPE product range provides unparalleled performances and satisfies the clients demand for Recovery, Reliability and Reproducibility ...
Chapter 1: Combinatorial Materials Science: Measures of Success (Michael J. Fasolka and Eric J. Amis). Chapter 2: Experimental Design in High Throughput Systems (James N. Cawse).. Chapter 3: Polymeric Discrete Libraries for High-Throughput Materials Science: Conventional and Microfluidic Library Fabrication and Synthesis (Kathryn L. Beers and Brandon M. Vogel).. Chapter 4: Strategies in the Use of Atomic Force Microscopy as a Multiplexed Readout Tool of Chip-Scale Protein Motifs (Jeremy R. Kenseth, Karen M. Kwarta, Jeremy D. Driskell, and Marc D. Porter, John D. Neill and Julia F. Ridpath).. Chapter 5: Informatics Methods for Combinatorial Materials Science (Changwon Suh, Krishna Rajana, Brandon M. Vogel, Balaji Narasimhan, and Surya K. Mallapragada).. Chapter 6: Combinatorial Approaches and Molecular Evolution of Homogeneous Catalysts (L. Keith Woo).. Chapter 7: Biomaterials Informatics (Nicole K. Harris, Joachim Kohn, W.J. Welsh, and Doyle Knight).. Chapter 8: Combinatorial Methods and their ...
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An efficient method to synthesize positional scanning synthetic combinatorial libraries (PS-SCLs) for studying the specificity of protein kinases is presented. Isokinetic ratios for pentafluorophenyl esters were determined iteratively using a new approach incorporating high performance liquid chromatography (HPLC) quantification and statistical experimental design. In the development process a large amount of work was put in to find efficient ways of screening for new isokinetic mixtures and to optimize the process of PS-SCL synthesis. The newly developed methods for the screening of isokinetic mixtures could be used for the screening of other interesting mixtures, but more importantly, the isokinetic ratios determined for the preactivated pentafluorophenyl esters were incorporated into a new efficient protocol. This straightforward protocol allows for a convenient synthesis of high quality PS-SCLs regardless of previous experience in solid phase synthesis.
Real-time reaction monitoring based on a combination of thin-layer chromatography (TLC) and compact mass spectrometry (CMS) is a simple and quick way for chemists to overcome synthetic challenges and optimize chemical reactions in the modern laboratory. Peptides of pharmaceutical interest can be readily synthesized following a rapid, continuous solution-phase synthesis strategy based on Fmoc protected amino acid building blocks. A simple model for such a reaction is the growing of analogues of the acyl carrier protein (ACP), a component of the fatty acid synthesis pathway.. ...
Diffusion ordered spectroscopy (DOSY) NMR experiments have been used to characterize a dynamic combinatorial library of helical strands and grid-type metallosupramolecular architectures. The technique allows the deconvolution of very similar chemical structures differing only by their hydrodynamic radius. Moreover, the occurrence of springlike, extension-contraction conformational motions in helical strands can be revealed as a function of the temperature. ...
Sorrento Therapeutics, Inc. (OTC Bulletin Board: SRNE) today announced that it has completed the construction of an extensive library of full-length, fully human monoclonal antibodies
ACS Short Course Computational Chemistry and Computer-Assisted Drug Design: Practical Approaches 230th ACS National Meeting Washington Convention Center, Washington, DC Friday-Saturday, August 26-27, 2005 This introductory level course is designed for organic chemists, pharmaceutical chemists, and biochemists who are interested in learning more about computational and combinatorial methods, or scientists who need to develop a working knowledge of the fundamentals and need to understand the concepts and terminology of this rapidly developing area. Program Overview of Computational Chemistry and Computer-Assisted Drug Design Molecular Mechanics: Background, Development, Concepts, Force Fields Conformational Searching Molecular Dynamics Simulations: Background, Development, Concepts, and Applications Protein Structure Prediction Overview of Quantum Chemistry Methods and Its Application to Drug Design DNA and Protein Sequence and Structure Analysis Drug Design Methods and Pharmacophore Design QSAR ...
Good methods must be reliable, well-tested, and honed to minimize the time and expense required to achieve the desired results. CPNC provides a continuously growing and evolving set of protocols that allows researchers to benefit from the experience of other researchers around the world. The core manual provides a comprehensive set of protocols that have been compiled, revised, and streamlined over the last 6 years. Quarterly updates provide new protocols in emerging areas of research as well as continued advances and new applications for fundamental methods. The book is designed to grow and change with the field of nucleic acid chemistry. Fundamental nucleoside chemistry methods include sugar-base condensation, phosphorylation, and nucleoside protection. Methods for oligonucleotide synthesis include H-phosphonate and phosphoramidite approaches, solid-phase and solution-phase synthesis, large-scale synthesis, synthesis for modified and unmodified oligonucleotides, conjugation of ...
Mark Wheelis Biology is in the midst of what can only be described as a revolution. It began in the mid-1970s with the development of recombinant DNA technology. Slowly at first but with increasing speed, related technologies have been developed that have dramatically expanded the experimental capabilities of modern research biologists and that are rapidly being adopted in such areas of applied biology as drug development. These new technologies include genomics, proteomics, microarray technology, high-throughput screening techniques, combinatorial methods in both chemistry and biology, site-specific mutagenesis, knock-out mice, and many others.[1] Collectively, these technologies are referred to as genomic sciences, or the "new biology.". This technology will have great power both for peaceful and hostile uses. Peaceful applications will include a wide range of new therapeutic agents of much greater specificity and safety than are currently available; hostile applications could include a wide ...
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IMSEAR is the collaborative product of Health Literature, Library and Information Services (HELLIS) Network Member Libraries in the WHO South-East Asia Region ...
IMSEAR is the collaborative product of Health Literature, Library and Information Services (HELLIS) Network Member Libraries in the WHO South-East Asia Region ...
The fct L10-FeNi alloy is a promising candidate for the development of high performance critical-elements-free magnetic materials. Among the different materials, the Au-Cu-Ni alloy has resulted very promising; however, a detailed investigation of the effect of the buffer-layer composition on the formation of the hard FeNi phase is still missing. To accelerate the search of the best Au-Cu-Ni composition, a combinatorial approach based on High-Throughput (HT) experimental methods has been exploited in this paper. HT magnetic characterization methods revealed the presence of a hard magnetic phase with an out-of-plane easy-axis, whose coercivity increases from 0.49 kOe up to 1.30 kOe as the Au content of the Cu-Au-Ni buffer-layer decreases. Similarly, the out-of-plane magneto-crystalline anisotropy energy density increases from 0.12 to 0.35 MJ/m3. This anisotropy is attributed to the partial formation of the L10 FeNi phase induced by the buffer-layer. In the range of compositions we investigated, the buffer
Swartz, Michael E. (2000-02-18). Analytical Techniques in Combinatorial Chemistry. CRC Press. pp. 278-279. ISBN 9780203909966. ... In 2002, Koichi Tanaka, a longstanding employee, won the Nobel Prize in Chemistry for developing a method of mass spectrometric ... Japan portal Electronics portal Analytical chemistry portal Companies portal List of companies of Japan List of scientific ...
These techniques are complemented by laboratory methods from combinatorial chemistry, molecular biology and functional genomics ... statistical analysis and chemoinformatic techniques, a recent and innovative international concept registered under the name " ...
A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry". ... Easy to use graphical user interface desktop chemistry editor JChemPaint. GNU LGPL. cross-platform. 2D structural formula ... HTML5 chemistry web components including viewers, animations, interactive components and editors; uses Canvas and WebGL ... Methods and Principles in Medicinal Chemistry. pp. 271-285. doi:10.1002/3527603743.ch11. ISBN 9783527307531. .. .mw-parser- ...
Used primarily in the synthesis of medicinal drugs, solution-phase combinatorial chemistry allows for the creation of large ... Reaction may be monitored: The purification process is controlled Traditional purity techniques may be employed Can be used in ... Carlisle, Steven J. , Marsh, Andrew, Smith, S.C. (2001). "High-loading scavenger resins for combinatorial chemistry". ... Employment of scavenger resins has become increasingly popular in solution-phase combinatorial chemistry. ...
A Powerful New Technique for Identifying Privileged Molecular Fragments with Useful Applications in Combinatorial Chemistry J. ... RECAP (Retrosynthetic Combinatorial Analysis Procedure) uses SMARTS to define bond types. RECAP is a molecule editor which ... 54, 255-271 Lewell, X.Q.; Judd, D.B; Watson, S.P.; Hann, M.M. (1998) RECAP-Retrosynthetic Combinatorial Analysis Procedure: ...
Cope Award and the Wolf Prize in Chemistry. ACS Award in Pure Chemistry (1989) "For pioneering investigations into the ... DOS pathways and new techniques for small-molecule screening provided many new, potentially disruptive insights into biology. ... combinatorial synthesis and the so-called Build/Couple/Pair strategy of modular chemical synthesis. ... "For outstanding achievement in creative chemistry." Eli Lilly Award in Biological Chemistry, ACS (1993). "For fundamental ...
... she developed combinatorial chemistry and molecular graphics techniques and was involved in the development of software ... She was the only woman to be a chemistry/zoology major in her year. From 1958 to 1960 she worked as a pharmacology assistant at ... Editorially, she has worked on Perspectives in Drug Design and Discovery, QSAR: Annual Reports in Computational Chemistry, ... She has also significantly contributed to the development of compound collections and combinatorial libraries which ...
... or from historic chemical compound collections or libraries created through combinatorial chemistry. While a number of ... approaches toward the identification and development of hits exist, the most successful techniques are based on chemical and ... Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic ... Medicinal chemistry is by nature an interdisciplinary science, and practitioners have a strong background in organic chemistry ...
... companies to adopt an explicit strategy of rational drug design as opposed to techniques based on combinatorial chemistry. This ...
DEL is used in medicinal chemistry to bridge the fields of combinatorial chemistry and molecular biology. The aim of DEL ... The technique enables the mass creation and interrogation of libraries via affinity selection, typically on an immobilized ... Genetic manipulation of combinatorial chemistry libraries for small-molecule evolution". PLoS Biol. 2 (7): E174. doi:10.1371/ ... In order to apply combinatorial chemistry for the synthesis of DNA-encoded chemical libraries, a Split-&-Pool approach was ...
The advent of combinatorial chemistry has enabled medicinal chemists to synthesize and identify large numbers of potential ... Micellar electrokinetic chromatography (MEKC), is a chromatography technique, used in analytical chemistry. It is a ... Simms, P.J.; Jeffries, C.T.; Huang, Y.; Zhang, L.; Arrhenius, T.; Nadzan, A.M. (2001). "Analysis of Combinatorial Chemistry ... In MEKC, however, techniques must be used to extend the elution range to separate strongly retained analytes. Elution ranges ...
... is a combinatorial chemistry technique in molecular biology for producing oligonucleotides of either single-stranded DNA or RNA ... The technique has been used to evolve aptamers of extremely high binding affinity to a variety of target ligands, including ... Clinical uses of the technique are suggested by aptamers that bind tumor markers,, GFP-related fluorophores, and a VEGF-binding ... Carmi, Nir; Shultz, Lisa A.; Breaker, Ronald R. (Dec 1996). "In vitro selection of self-cleaving DNAs". Chemistry & Biology. 3 ...
Materials science has applied the techniques of combinatorial chemistry to the discovery of new materials. This work was ... formerly Journal of Combinatorial Chemistry) Combinatorial Chemistry Review Molecular Diversity Combinatorial Chemistry and ... The methods used in combinatorial chemistry are applied outside chemistry, too. Synthesis of molecules in a combinatorial ... "The concealed side of the history of combinatorial chemistry" IUPAC's "Glossary of Terms Used in Combinatorial Chemistry" ACS ...
... protein-directed dynamic combinatorial chemistry and organic synthesis/medicinal chemistry. Most clinically used antibiotics ... Techniques involved in this interdisciplinary research include proteomics, X-ray crystallography, nuclear magnetic resonance ( ... In 1998, he became professor of Chemistry, and in 2011 he was appointed the Head of Organic Chemistry at the Department of ... Chris Schofield is a professor of organic chemistry at the University of Oxford, Department of Chemistry and a Fellow of ...
Several analytical techniques have been applied to the analysis of protein-directed DCL. These include HPLC, mass spectrometry ... Protein-directed dynamic combinatorial chemistry. In Dynamic combinatorial chemistry: in drug discovery, bioinorganic chemistry ... Center for Dynamic Combinatorial Chemistry[citation needed] University of Cambridge: Dynamic Combinatorial Chemistry. ... Dynamic combinatorial chemistry (DCC; also known as dynamic covalent chemistry) is a method to the generation of new molecules ...
... the application of high throughput and combinatorial approaches and biophysical chemistry, which focuses on the development and ... polymer microarray technologies and technique development for materials and nanomaterials analysis. RAE 2008: chemistry results ... The teaching of Chemistry at Edinburgh began in 1713 when James Crawford was appointed to the Chair of Physics and Chemistry. ... The Materials Chemistry group is one of the largest materials chemistry groups in the UK. Areas of strength include the design ...
Protein-directed dynamic combinatorial chemistry". In Miller BL. Dynamic combinatorial chemistry: in drug discovery, ... Nuclear magnetic resonance spectroscopy is the primary technique for determining chemical structures of natural products. NMR ... selection of different binders from the same uridine-based dynamic combinatorial library". Journal of Combinatorial Chemistry. ... Despite the rise of combinatorial chemistry as an integral part of lead discovery process, natural products still play a major ...
"Combinatorial chemistry in the agrosciences". Bioorganic & Medicinal Chemistry. 17 (12): 4035. doi:10.1016/j.bmc.2009.03.027. ... Techniques such as fragment-based design, virtual screening and genome sequencing have helped generate drug leads. Published ... The sources of new molecules employ natural products, competitors, universities, chemical vendors, combinatorial chemistry ... "Screening technique uncovers five new plant activator compounds". Phys.org. Retrieved 2014-02-11. Yoshiteru Noutoshia, Masateru ...
Journal of Combinatorial Chemistry, 7, 921-928, 2005. B.M. Vogel and S.K. Mallapragada, "The Synthesis of Polyanhydrides", in ... "Polyanhydride Synthesis Techniques." Wyatt Technology Corp. http://www.lightscattering.com/literature/polyanhydride.pdf Tamada ... These classes are determined by examining their R groups (the chemistry of the molecule between the anhydride bonds). Aliphatic ...
Jameson, David (2003). "Fluorescence Polarization: Past, Present and Future". Combinatorial Chemistry & High Throughput ... Despite originating as a method for direct interaction studies, the technique has been adopted by high-throughput screening ( ... Eremin, SA (2003). "Fluorescence polarization immunoassays for pesticides". Combinatorial Chemistry & High Throughput Screening ... Combinatorial Chemistry & High Throughput Screening. 2: 177-190 - via ResearchGate. Smith, David (2008). "Fluorescence ...
Nuclear magnetic resonance (NMR) is one of the most powerful spectroscopic techniques in analytical chemistry. It is an ... and by doing so hope to gain further insight into the combinatorial outcome of these many, small, non-covalent forces that are ... In supramolecular chemistry, host-guest chemistry describes complexes that are composed of two or more molecules or ions that ... limits the accuracy of the technique. Raman spectroscopy is a spectroscopic technique used in the study of molecules which ...
Physical chemistry and chemical physics: Chemistry investigated via physical methods like laser techniques, scanning tunneling ... Examples are molecular docking, protein-protein docking, drug design, combinatorial chemistry. The fitting of shape and ... Theoretical chemistry is a branch of chemistry, which develops theoretical generalizations that are part of the theoretical ... Theoretical chemistry unites principles and concepts common to all branches of chemistry. Within the framework of theoretical ...
"Enhancement of Combinatorial Chemistry by Microwave-Assisted Organic Synthesis". Combinatorial Chemistry & High Throughput ... Oberhofer, M.; Scharmann, A. (1993). Techniques and Management of Personnel Thermoluminescence Dosimetry Services. Current ... "Royal Society of Chemistry. Consultado o 27 de setembro de 2010.. *↑ 10,0 10,1 Lynch, Charles T. (1974). CRC Handbook of ... Royal Society of Chemistry: 125. ISBN 9780851863382. ISSN 0305-9987.. *↑ 69,0 69,1 "Cesium Atoms at Work". Time Service ...
Combinatorial chemistry Congener Conformation activity relationship Quantitative structure-activity relationship Sims, Gerald; ... Medicinal chemists use the techniques of chemical synthesis to insert new chemical groups into the biomedical compound and test ... Sommers (1986). "Biodegradation of pyridine derivatives in soil suspensions". Environmental Toxicology and Chemistry. 5: 503- ...
The CombiMatrix microarray ("CombiMatrix" refers to combinatorial chemistry on a matrix array) was born and received US patents ... CombiMatrix performs genetic testing utilizing a variety of advanced cytogenomic techniques, including chromosomal microarray ...
FISH is a very general technique. The differences between the various FISH techniques are usually due to variations in the ... For miRNA detection, the probes use proprietary chemistry for specific detection of miRNA and cover the entire miRNA sequence. ... Three primary fluorophores are able to generate a total of 7 readily detectable emission spectra as a result of combinatorial ... This technique is used routinely in telomere length research. Flow-FISH[edit]. Flow-FISH uses flow cytometry to perform FISH ...
Combinatorial Chemistry Techniques. Genetic Vectors. Immunoglobulin Fab Fragments / biosynthesis*, immunology. Peptide Library* ... In this paper, we describe an elegant and simple method for constructing large combinatorial Fab libraries for display on the ...
5.1.1 The design of combinatorial syntheses 147. 5.1.2 The general techniques used in combinatorial synthesis 148 ... "Medicinal Chemistry is certainly a text I would chose to teach from for undergraduates. It fills a unique niche in the market ... Medicinal Chemistry: An Introduction, Second Edition provides a comprehensive, balanced introduction to this evolving and ... Written in an accessible style, Medicinal Chemistry: An Introduction, Second Edition carefully explains fundamental principles ...
Combinatorial chemistry is one of these techniques. Currently, the technique is very time consuming. A need in the art exists ... Drug Development Through Combinatorial Chemistry. Combinatorial chemistry is the synthesis of large numbers of compounds that ... Using the combinatorial chemistry technique, one typically begins with a molecule or compound known to be useful. The substance ... The intent of combinatorial chemistry efforts includes: 1) lead generation, 2) lead optimization, and 3) combinatorial mixtures ...
Analytical Techniques in Combinatorial Chemistry (Hardback) Edited by Swartz, Michael E. *RRP: $419.00 ... Where? Books » Category » Technology, Engineering & Agriculture » Industrial Chemistry & Manufacturing Technologies » ... This title describes the chromatographic and spectroscopic techniques used to generate chemical and molecular diversity in ...
Combinatorial Chemistry Techniques* * Organ Specificity * Peptide Library* * Receptors, Cell Surface / chemistry Substances * ... New Approaches for Cell-Specific Targeting: Identification of Cell-Selective Peptides From Combinatorial Libraries Curr Opin ...
To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems ... Quality measurement, control, and improvement in combinatorial chemistry. Combinatorial chemistry has developed rapidly in the ... combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics. About the Author. ... Analysis and Purification Methods in Combinatorial Chemistry. Bing Yan (Editor). ISBN: 978-0-471-53197-5 January 2004 480 Pages ...
Combinatorial chemistry is increasingly being used by pharmaceutical companies in their search for new drugs. ... Combinatorial chemistry is a group of techniques for synthesising large arrays of related chemicals. These can be easily ... Combinatorial chemistry is a group of techniques for synthesising large arrays of related chemicals. These can be easily ... Combinatorial chemistry is a group of techniques for synthesising large arrays of related chemicals. These can be easily ...
Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. ... Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews ... Screening GLP-1 Receptor Ligands from Natural Products in Herbs through High-Content Technique. , 2019; 22(7): 445 - 454. ... Combinatorial Chemistry & High Throughput Screening. Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry ...
Novel Techniques in Combinatorial Chemistry. p. 371. Reviews. p. 372. Author Index. p. 375. ...
Combinatorial chemistry; Graph theory in chemistry; Prediction of drug toxicity; Property prediction; Molecular mechanics and ... Bioimaging ( Image processing in medicine and biological sciences; Measurements techniques; Mass spectrometry; Numerical( ... Mathematical chemistry and chemical graphs; In silico environmental toxicology; Computer-assisted chemical engineering; ... Techniques for gene expression analysis; Modeling and simulation of biomarkers) ...
Combinatorial chemistry; Graph theory in chemistry; Prediction of drug toxicity; Property prediction; Molecular mechanics and ... Biotechnology is defined as the industrial use of living organisms or biological techniques developed through basic research. ... Bioimaging ( Image processing in medicine and biological sciences; Measurements techniques; Mass spectrometry; Numerical( ... Mathematical chemistry and chemical graphs; In silico environmental toxicology; Computer-assisted chemical engineering; ...
Methods to allow the clean preparation of oligosaccharides were investigated using techniques that do not require conventional ... Combinatorial Chemistry Techniques / methods*. Glycosides / chemistry. Glycosylation. Iodine / chemistry. Molecular Sequence ... Title: Organic & biomolecular chemistry Volume: 1 ISSN: 1477-0520 ISO Abbreviation: Org. Biomol. Chem. Publication Date: 2003 ... Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.. ...
... the need for new approaches to biomaterials discovery as well as the significant promise inherent in the use of combinatorial ... Biocompatible Materials / chemistry*. Combinatorial Chemistry Techniques / methods*, trends. Computer Simulation. Models, ... Previous Document: Influence of substratum surface chemistry/energy and topography on the human fetal osteoblastic cell.... ... Once combinatorial synthesis, high-throughput experimentation, and computational modeling are integrated into the biomaterials ...
Swartz, Michael E. (2000-02-18). Analytical Techniques in Combinatorial Chemistry. CRC Press. pp. 278-279. ISBN 9780203909966. ... In 2002, Koichi Tanaka, a longstanding employee, won the Nobel Prize in Chemistry for developing a method of mass spectrometric ... Japan portal Electronics portal Analytical chemistry portal Companies portal List of companies of Japan List of scientific ...
Transducer Techniques, LLC. Transducer Techniques manufactures a complete line of Load Cells,... ... Combinatorial Chemistry. Comprehensive information on combinatorial chemistry and high.... Explore All Collections in Your City ...
Method and system for inhibiting cross-contamination in fluids of combinatorial chemistry device. ... Bead Manipulation Techniques. US20110118132 *. 25 Jan 2011. 19 May 2011. Advanced Liquid Logic, Inc.. Enzymatic Assays Using ... Bead manipulation techniques. US9091649. 8 Nov 2010. 28 Jul 2015. Advanced Liquid Logic, Inc.. Integrated droplet actuator for ... Techniques and droplet actuator designs for reducing bubble formation. US9816133. 8 Oct 2013. 14 Nov 2017. cole Polytechnique. ...
Another problem with combinatorial chemistry, says Harren Jhoti of Astex, is that over time, the compounds it produced were ... But now they are making a comeback in the form of novel twists on combinatorial techniques. ... The enthusiasm for combinatorial chemistry also diverted attention away from compounds derived from natural products. Once a ... As a result, much effort is now being focused on using combinatorial chemistry and high-throughput screening more appropriately ...
Bioorganic Chemistry, and Materials Science - Author: Miller, Benjamin L. - Price: 81,70€ ... Effective techniques for applying Dynamic Combinatorial Chemistry. In a relatively short period, Dynamic Combinatorial ... Dynamic Combinatorial Chemistry : In Drug Discovery, Bioorganic Chemistry, and Materials Science. 81,70€ ... Dynamic Combinatorial Chemistry. In Drug Discovery, Bioorganic Chemistry, and Materials Science. Edited by. Benjamin L. Miller ...
Stochastic Processes; Protein Engineering; Algorithms; Proteins; Combinatorial Chemistry Techniques; Probability, Databases: ... Here, we study four common search techniques: Monte Carlo (MC) and Monte Carlo plus quench (MCQ); genetic algorithms (GA); self ...
Combinatorial chemistry; Graph theory in chemistry; Prediction of drug toxicity; Property prediction; Molecular mechanics and ... Bioimaging ( Image processing in medicine and biological sciences; Measurements techniques; Mass spectrometry; Numerical( ... Techniques for gene expression analysis; Modeling and simulation of biomarkers) Advanced biocomputation technologies ( ... Mathematical chemistry and chemical graphs; In silico environmental toxicology; Computer-assisted chemical engineering; ...
Combinatorial chemistry techniques can generate thousands or millions of compounds (combinatorial libraries) in a relatively ... Techniques for generating large numbers of compounds, for example through combinatorial chemistry, have been established. High- ... For example, combinatorial chemistry is often employed to discover new lead compounds, or to create variations of a lead ... 23B shows a cross-sectional view of the chip-based combinatorial chemistry system of FIG. 23A taken along line M-2313; ...
... and combinatorial chemistry to generate large numbers of candidate drug structures. SPECIAL REQUIREMENTS Patent Coverage. Since ... and computational techniques to allow the determination of three-dimensional structure; advances in screening technology to ... molecular structure determined through biophysical techniques as a prelude to drug discovery studies . These aspects are ...
... which are adapted for combinatorial chemistry. Any of the embodiments of the invention may be used either alone or taken in ... The array, array cover, and the stage may be modified as required for a variety of synthesis and/or analysis techniques. The ... screening and/or characterization of combinatorial libraries. The invention relates to an array, which permits various high- ... Combinatorial Chemistry Process. The invention also relates to a combinatorial chemistry process, used for the synthesis of ...
Combinatorial Chemistry and New Drugs An innovative technique that quickly produces large numbers of structurally related ...
Combinatorial Chemistry, Chemoinformatics, Laboratory Automation and Compound management) in advancing drug discovery research. ... Combinatorial Chemistry & High Throughput Screening (CCHTS) publishes full length original research articles and reviews ... Machine learning techniques for high-throughput structure and function analysis for proteomics and genomics. Guest Editor(s): ... Combinatorial Chemistry & High Throughput Screening. Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry ...

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