Liver Neoplasms: Tumors or cancer of the LIVER.Liver Neoplasms, Experimental: Experimentally induced tumors of the LIVER.Pancreas: A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Rats, Inbred F344Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.Liver Diseases: Pathological processes of the LIVER.Pancreas Transplantation: The transference of a pancreas from one human or animal to another.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Adenoma: A benign epithelial tumor with a glandular organization.Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.Pancreas, Exocrine: The major component (about 80%) of the PANCREAS composed of acinar functional units of tubular and spherical cells. The acinar cells synthesize and secrete several digestive enzymes such as TRYPSINOGEN; LIPASE; AMYLASE; and RIBONUCLEASE. Secretion from the exocrine pancreas drains into the pancreatic ductal system and empties into the DUODENUM.Colonoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the colon.Liver Regeneration: Repair or renewal of hepatic tissue.Microsomes, Liver: Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.Fatty Liver: Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.Adenocarcinoma: A malignant epithelial tumor with a glandular organization.Colonic Neoplasms: Tumors or cancer of the COLON.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Colorectal Neoplasms, Hereditary Nonpolyposis: A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.Colorectal Surgery: A surgical specialty concerned with the diagnosis and treatment of disorders and abnormalities of the COLON; RECTUM; and ANAL CANAL.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Rectal Neoplasms: Tumors or cancer of the RECTUM.Colonic Polyps: Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Neoplasms, Cystic, Mucinous, and Serous: Neoplasms containing cyst-like formations or producing mucin or serum.Liver Function Tests: Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Mitochondria, Liver: Mitochondria in hepatocytes. As in all mitochondria, there are an outer membrane and an inner membrane, together creating two separate mitochondrial compartments: the internal matrix space and a much narrower intermembrane space. In the liver mitochondrion, an estimated 67% of the total mitochondrial proteins is located in the matrix. (From Alberts et al., Molecular Biology of the Cell, 2d ed, p343-4)Pancreatic Ducts: Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.Pancreatic Diseases: Pathological processes of the PANCREAS.Rectum: The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.Drug-Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.Pancreatectomy: Surgical removal of the pancreas. (Dorland, 28th ed)DNA, Neoplasm: DNA present in neoplastic tissue.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Hepatectomy: Excision of all or part of the liver. (Dorland, 28th ed)Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Sigmoidoscopy: Endoscopic examination, therapy or surgery of the sigmoid flexure.Carcinoma, Pancreatic Ductal: Carcinoma that arises from the PANCREATIC DUCTS. It accounts for the majority of cancers derived from the PANCREAS.Adenomatous Polyps: Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)Pancreas, Artificial: Devices for simulating the activity of the pancreas. They can be either electromechanical, consisting of a glucose sensor, computer, and insulin pump or bioartificial, consisting of isolated islets of Langerhans in an artificial membrane.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Pancreatitis: INFLAMMATION of the PANCREAS. Pancreatitis is classified as acute unless there are computed tomographic or endoscopic retrograde cholangiopancreatographic findings of CHRONIC PANCREATITIS (International Symposium on Acute Pancreatitis, Atlanta, 1992). The two most common forms of acute pancreatitis are ALCOHOLIC PANCREATITIS and gallstone pancreatitis.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Liver Circulation: The circulation of BLOOD through the LIVER.Islets of Langerhans: Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.Liver Extracts: Extracts of liver tissue containing uncharacterized specific factors with specific activities; a soluble thermostable fraction of mammalian liver is used in the treatment of pernicious anemia.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Carcinoembryonic Antigen: A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.Cystadenoma, Mucinous: A multilocular tumor with mucin secreting epithelium. They are most often found in the ovary, but are also found in the pancreas, appendix, and rarely, retroperitoneal and in the urinary bladder. They are considered to have low-grade malignant potential.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Skin Neoplasms: Tumors or cancer of the SKIN.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Neoplasm Invasiveness: Ability of neoplasms to infiltrate and actively destroy surrounding tissue.Amylases: A group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans. (Stedman, 25th ed) EC 3.2.1.-.Organoplatinum Compounds: Organic compounds which contain platinum as an integral part of the molecule.Leucovorin: The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.Intestinal Polyps: Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Lung Neoplasms: Tumors or cancer of the LUNG.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.Cell Line, Tumor: A cell line derived from cultured tumor cells.Adenomatous Polyposis Coli: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.Cystadenoma: A benign neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. In some instances, considerable portions of the neoplasm, or even the entire mass, may be cystic. (Stedman, 25th ed)Kidney Neoplasms: Tumors or cancers of the KIDNEY.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Liver Abscess: Solitary or multiple collections of PUS within the liver as a result of infection by bacteria, protozoa, or other agents.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Liver Diseases, Alcoholic: Liver diseases associated with ALCOHOLISM. It usually refers to the coexistence of two or more subentities, i.e., ALCOHOLIC FATTY LIVER; ALCOHOLIC HEPATITIS; and ALCOHOLIC CIRRHOSIS.Choristoma: A mass of histologically normal tissue present in an abnormal location.Mass Screening: Organized periodic procedures performed on large groups of people for the purpose of detecting disease.Microsatellite Repeats: A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).Early Detection of Cancer: Methods to identify and characterize cancer in the early stages of disease and predict tumor behavior.Survival Analysis: A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.Camptothecin: An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.Gastrointestinal Neoplasms: Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Genes, ras: Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.Cystadenoma, Serous: A cystic tumor of the ovary, containing thin, clear, yellow serous fluid and varying amounts of solid tissue, with a malignant potential several times greater than that of mucinous cystadenoma (CYSTADENOMA, MUCINOUS). It can be unilocular, parvilocular, or multilocular. It is often bilateral and papillary. The cysts may vary greatly in size. (Dorland, 27th ed; from Hughes, Obstetric-Gynecologic Terminology, 1972)Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Antigens, Neoplasm: Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.Carcinoma, Papillary: A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)Hepatocytes: The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.MutS Homolog 2 Protein: MutS homolog 2 protein is found throughout eukaryotes and is a homolog of the MUTS DNA MISMATCH-BINDING PROTEIN. It plays an essential role in meiotic RECOMBINATION and DNA REPAIR of mismatched NUCLEOTIDES.HT29 Cells: Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.Neoplasms, Experimental: Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Cystadenocarcinoma, Mucinous: A malignant cystic or semisolid tumor most often occurring in the ovary. Rarely, one is solid. This tumor may develop from a mucinous cystadenoma, or it may be malignant at the onset. The cysts are lined with tall columnar epithelial cells; in others, the epithelium consists of many layers of cells that have lost normal structure entirely. In the more undifferentiated tumors, one may see sheets and nests of tumor cells that have very little resemblance to the parent structure. (Hughes, Obstetric-Gynecologic Terminology, 1972, p184)Colectomy: Excision of a portion of the colon or of the whole colon. (Dorland, 28th ed)Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Pancreatic Juice: The fluid containing digestive enzymes secreted by the pancreas in response to food in the duodenum.Endocrine Gland Neoplasms: Tumors or cancer of the ENDOCRINE GLANDS.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.DNA Methylation: Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Genes, APC: Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Precancerous Conditions: Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)Thyroid Neoplasms: Tumors or cancer of the THYROID GLAND.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Carcinoma, Acinar Cell: A malignant tumor arising from secreting cells of a racemose gland, particularly the salivary glands. Racemose (Latin racemosus, full of clusters) refers, as does acinar (Latin acinus, grape), to small saclike dilatations in various glands. Acinar cell carcinomas are usually well differentiated and account for about 13% of the cancers arising in the parotid gland. Lymph node metastasis occurs in about 16% of cases. Local recurrences and distant metastases many years after treatment are common. This tumor appears in all age groups and is most common in women. (Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1240; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p575)Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.Adenocarcinoma, Papillary: An adenocarcinoma containing finger-like processes of vascular connective tissue covered by neoplastic epithelium, projecting into cysts or the cavity of glands or follicles. It occurs most frequently in the ovary and thyroid gland. (Stedman, 25th ed)HCT116 Cells: Human COLORECTAL CARCINOMA cell line.Immunoenzyme Techniques: Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.Rectal Diseases: Pathological developments in the RECTUM region of the large intestine (INTESTINE, LARGE).beta Catenin: A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.Myeloproliferative Disorders: Conditions which cause proliferation of hemopoietically active tissue or of tissue which has embryonic hemopoietic potential. They all involve dysregulation of multipotent MYELOID PROGENITOR CELLS, most often caused by a mutation in the JAK2 PROTEIN TYROSINE KINASE.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Liver Cirrhosis, Experimental: Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.Pancreatic Cyst: A true cyst of the PANCREAS, distinguished from the much more common PANCREATIC PSEUDOCYST by possessing a lining of mucous EPITHELIUM. Pancreatic cysts are categorized as congenital, retention, neoplastic, parasitic, enterogenous, or dermoid. Congenital cysts occur more frequently as solitary cysts but may be multiple. Retention cysts are gross enlargements of PANCREATIC DUCTS secondary to ductal obstruction. (From Bockus Gastroenterology, 4th ed, p4145)Antineoplastic Combined Chemotherapy Protocols: The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.Appendiceal Neoplasms: Tumors or cancer of the APPENDIX.Bile Duct Neoplasms: Tumors or cancer of the BILE DUCTS.Liver Cirrhosis, Alcoholic: FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Ceruletide: A specific decapeptide obtained from the skin of Hila caerulea, an Australian amphibian. Caerulein is similar in action and composition to CHOLECYSTOKININ. It stimulates gastric, biliary, and pancreatic secretion; and certain smooth muscle. It is used in paralytic ileus and as diagnostic aid in pancreatic malfunction.Proto-Oncogene Proteins B-raf: A raf kinase subclass found at high levels in neuronal tissue. The B-raf Kinases are MAP kinase kinase kinases that have specificity for MAP KINASE KINASE 1 and MAP KINASE KINASE 2.Cystadenocarcinoma: A malignant neoplasm derived from glandular epithelium, in which cystic accumulations of retained secretions are formed. The neoplastic cells manifest varying degrees of anaplasia and invasiveness, and local extension and metastases occur. Cystadenocarcinomas develop frequently in the ovaries, where pseudomucinous and serous types are recognized. (Stedman, 25th ed)Pancreaticoduodenectomy: The excision of the head of the pancreas and the encircling loop of the duodenum to which it is connected.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Diet: Regular course of eating and drinking adopted by a person or animal.Digestive System Neoplasms: Tumors or cancer of the DIGESTIVE SYSTEM.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Stomach Neoplasms: Tumors or cancer of the STOMACH.Neoplasm Transplantation: Experimental transplantation of neoplasms in laboratory animals for research purposes.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Tumor Cells, Cultured: Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.Hepatic Artery: A branch of the celiac artery that distributes to the stomach, pancreas, duodenum, liver, gallbladder, and greater omentum.ras Proteins: Small, monomeric GTP-binding proteins encoded by ras genes (GENES, RAS). The protooncogene-derived protein, PROTO-ONCOGENE PROTEIN P21(RAS), plays a role in normal cellular growth, differentiation and development. The oncogene-derived protein (ONCOGENE PROTEIN P21(RAS)) can play a role in aberrant cellular regulation during neoplastic cell transformation (CELL TRANSFORMATION, NEOPLASTIC). This enzyme was formerly listed as EC 126.96.36.199.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Proto-Oncogene Proteins: Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.Parotid Neoplasms: Tumors or cancer of the PAROTID GLAND.Liver, Artificial: Devices for simulating the activities of the liver. They often consist of a hybrid between both biological and artificial materials.Liver Glycogen: Glycogen stored in the liver. (Dorland, 28th ed)Antimetabolites, Antineoplastic: Antimetabolites that are useful in cancer chemotherapy.Germ-Line Mutation: Any detectable and heritable alteration in the lineage of germ cells. Mutations in these cells (i.e., "generative" cells ancestral to the gametes) are transmitted to progeny while those in somatic cells are not.Alanine Transaminase: An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 188.8.131.52.DNA Mismatch Repair: A DNA repair pathway involved in correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. Excinucleases recognize the BASE PAIR MISMATCH and cause a segment of polynucleotide chain to be excised from the daughter strand, thereby removing the mismatched base. (from Oxford Dictionary of Biochemistry and Molecular Biology, 2001)Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Neoplasms, Connective and Soft Tissue: Neoplasms developing from some structure of the connective and subcutaneous tissue. The concept does not refer to neoplasms located in connective or soft tissue.Sigmoid Neoplasms: Tumors or cancer of the SIGMOID COLON.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Neoplasms, Plasma Cell: Neoplasms associated with a proliferation of a single clone of PLASMA CELLS and characterized by the secretion of PARAPROTEINS.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Colonic Diseases: Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Organ Specificity: Characteristic restricted to a particular organ of the body, such as a cell type, metabolic response or expression of a particular protein or antigen.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Secretin: A peptide hormone of about 27 amino acids from the duodenal mucosa that activates pancreatic secretion and lowers the blood sugar level. (USAN and the USP Dictionary of Drug Names, 1994, p597)Glucagon: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)Portal Vein: A short thick vein formed by union of the superior mesenteric vein and the splenic vein.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Mice, Nude: Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.End Stage Liver Disease: Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.Fatal Outcome: Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Adenomatous Polyposis Coli Protein: A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Organ Size: The measurement of an organ in volume, mass, or heaviness.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Neoplasms, Radiation-Induced: Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation.Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Adaptor Proteins, Signal Transducing: A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymesNeoplasms, Glandular and Epithelial: Neoplasms composed of glandular tissue, an aggregation of epithelial cells that elaborate secretions, and of any type of epithelium itself. The concept does not refer to neoplasms located in the various glands or in epithelial tissue.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Nose Neoplasms: Tumors or cancer of the NOSE.Breast Neoplasms: Tumors or cancer of the human BREAST.Peritoneal Neoplasms: Tumors or cancer of the PERITONEUM.Loss of Heterozygosity: The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Splenic Neoplasms: Tumors or cancer of the SPLEEN.Pancreatitis, Chronic: INFLAMMATION of the PANCREAS that is characterized by recurring or persistent ABDOMINAL PAIN with or without STEATORRHEA or DIABETES MELLITUS. It is characterized by the irregular destruction of the pancreatic parenchyma which may be focal, segmental, or diffuse.
Cancer of unknown primary origin
Common primary sites for adenocarcinomas include the lung, pancreas, breast, prostate, stomach, liver, and colon.[medical ... It has been associated with familial lung, kidney, and colorectal cancers, which suggests that these sites may often be the ... citation needed] The remaining 10 percent are either poorly or undifferentiated malignant neoplasms (5%), or squamous cell ... such as the pancreas and liver.[medical citation needed] When the cancer cells are poorly differentiated (that is, they look ...
... benign or malignant neoplasms Large bowel obstruction caused by colorectal cancer, inflammatory bowel disease, volvulus, fecal ... Upper right abdominal pain Liver (caused by hepatomegaly due to fatty liver, hepatitis, or caused by liver cancer, abscess) ... About 10% of cases have a more serious cause including gallbladder (gallstones or biliary dyskinesia) or pancreas problems (4 ... Right low back pain liver pain (hepatomegaly) right kidney pain (its location below the area of liver pain) Left low back pain ...
The most common are lung cancer (1.4 million deaths), stomach cancer (740,000), liver cancer (700,000), colorectal cancer ( ... They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... This group includes many of the most common cancers and include nearly all those in the breast, prostate, lung, pancreas and ... colorectal cancer and stomach cancer. In females, the most common types are breast cancer, colorectal cancer, lung cancer and ...
The most common malignant neoplasms (cancers) of the liver are metastases; those arising from colorectal cancer are among the ... on liver cancer Video showing laprascopic liver resection. The Toronto Video Atlas of Liver, Pancreas and Transplant Surgery - ... Pancreas and Transplant Surgery - Video of Standard Left Hepatectomy procedure The Toronto Video Atlas of Liver, Pancreas and ... In the latter case, the patient was a 58-year-old woman diagnosed with colorectal cancer which had metastasized to the liver. ...
Surgical Outcomes Analysis and Research
The cystic tumors of the pancreas. In: Blumgart LH, ed. Surgery of the Liver, Biliary Tract and Pancreas. Philadelphia: ... Simons JP, Ng SC, Shah SA, McDade TP, Whalen GF, Tseng JF (2009). "Malignant Intraductal Papillary Mucinous Neoplasm: Are We ... Cooley EK, McPhee JT, Simons JP, Sweeney WB, Tseng JF, Alavi K. Colorectal neoplasia screening before age 50? "Current ... "Impact of center volume on increased risk liver transplant outcomes". Liver Transpl. 17: 1191-1199. doi:10.1002/lt.22343. ...
... liver, pancreas - Coordinated the General Surgery and Liver Transplantation Fundeni Center, with the direct result that this ... Led research in neoplasm genomic financed with grants won in national competition; during this process a brevet for genes ... involved in appearance of colorectal cancer was obtained in France For the laparoscopic surgery, Irinel Popescu: - Performed ... liver from living doner, reduced liver, domino transplatation) - Achieved national premieres like the first combined liver and ...
However, some pathologists (e.g., Odze and Goldblum, Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas, 2nd ... For example, neoplasms characterized by high-grade features, invasive glands and or signet ring cells, are termed ... Due to the increased availability of new chemotherapies developed for colon and colorectal cancer patients, some patients have ... and the majority of these patients can and do live productive lives. In debulking, the surgeon attempts to remove as much tumor ...
Juvenile polyposis syndrome
Pancreas. *exocrine pancreas: Adenocarcinoma. *Pancreatic ductal carcinoma. *cystic neoplasms: Serous microcystic adenoma ... The cumulative lifetime risk of colorectal cancer is 39% in patients with juvenile polyposis syndrome. ... Liver. *malignant: Hepatocellular carcinoma *Fibrolamellar. *Hepatoblastoma. *benign: Hepatocellular adenoma. *Cavernous ...
Pancreas. *exocrine pancreas: Adenocarcinoma. *Pancreatic ductal carcinoma. *cystic neoplasms: Serous microcystic adenoma ... Dig Liver Dis. 35 (6): 434-8. doi:10.1016/s1590-8658(03)00160-9. PMID 12868681.. ... colorectal polyp: Peutz-Jeghers syndrome. *Juvenile polyposis syndrome. *Familial adenomatous polyposis/Gardner's syndrome ...
Pancreas. *exocrine pancreas: Adenocarcinoma. *Pancreatic ductal carcinoma. *cystic neoplasms: Serous microcystic adenoma ... Chapter 92 (benign liver tumors). ISBN 978-0071466332. .. *^ Hussain S, van den Bos I, Dwarkasing R, Kuiper J, den Hollander J ... colorectal polyp: Peutz-Jeghers syndrome. *Juvenile polyposis syndrome. *Familial adenomatous polyposis/Gardner's syndrome ... Hepatocellular adenoma (also known as hepatic adenoma or hepadenoma) is a rare, benign liver tumor. It most commonly occurs in ...
Digestive system neoplasm
Pancreas. *exocrine pancreas: Adenocarcinoma. *Pancreatic ductal carcinoma. *cystic neoplasms: Serous microcystic adenoma ... colorectal polyp: Peutz-Jeghers syndrome. *Juvenile polyposis syndrome. *MUTYH-associated polyposis. *Familial adenomatous ... Liver. *malignant: Hepatocellular carcinoma *Fibrolamellar. *Hepatoblastoma. *benign: Hepatocellular adenoma. *Cavernous ... This article about a neoplasm is a stub. You can help Wikipedia by expanding it.. *v ...
Primary peritoneal carcinoma
Pancreas. *exocrine pancreas: Adenocarcinoma. *Pancreatic ductal carcinoma. *cystic neoplasms: Serous microcystic adenoma ... colorectal polyp: Peutz-Jeghers syndrome. *Juvenile polyposis syndrome. *Familial adenomatous polyposis/Gardner's syndrome ... Liver. *malignant: Hepatocellular carcinoma *Fibrolamellar. *Hepatoblastoma. *benign: Hepatocellular adenoma. *Cavernous ...
Pancreas. *exocrine pancreas: Adenocarcinoma. *Pancreatic ductal carcinoma. *cystic neoplasms: Serous microcystic adenoma ... They are known to grow in the liver, but this finding is usually a manifestation of metastatic disease from a primary carcinoid ... colorectal polyp: Peutz-Jeghers syndrome. *Juvenile polyposis syndrome. *Familial adenomatous polyposis/Gardner's syndrome ... If the tumor has metastasized (most commonly, to the liver) and is considered incurable, there are some promising treatment ...
This type of treatment is FDA approved for liver metastases secondary to colorectal carcinoma and is under investigation for ... About 95 percent of pancreatic tumors are adenocarcinoma; only 1 or 2% of clinically significant pancreas neoplasms are GEP- ... Arterial Chemotherapy Infusion of the Liver (and) Chemoembolization of the Liver (TACE) medicinenet.com; accessed November 8, ... G1 and G2 neuroendocrine neoplasms are called neuroendocrine tumors (NETs) - formerly called carcinoid tumours. G3 neoplasms ...
Chronically insufficient intake of folic acid may increase the risk of colorectal, breast, ovarian, pancreas, brain, lung, ... 1945). "Synthesis of a Compound Identical with the L. Casei Factor Isolated from Liver". Science. 102 (2644): 227-228. Bibcode: ... Folate deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of ... Their biological availability to the body depends upon dihydrofolate reductase action in the liver. This action is unusually ...
... pancreas, mammary gland, intestine, liver, thymus, lymph node, ovarian, muscle, lung, blood, and kidney tissues. The translated ... B-cell neoplasm, breast carcinoma, Burkitt's lymphoma, colorectal adenocarcinoma, carcinoma, cutaneous T cell lymphoma, ... esophageal carcinoma, gastric carcinoma, glioblastoma, liver carcinoma, lymphoma, melanoma, small cell lung carcinoma, T-cell ...
Tumors within the pancreas only (localized tumors), or with limited metastases, for example to the liver, may be removed by ... Pancreatic mucinous cystic neoplasms are a broad group of pancreas tumors that have varying malignant potential. They are being ... Kidney cancer is by far the most common cancer to spread to the pancreas, followed by colorectal cancer, and then cancers of ... A fourth type of cancer that arises in the pancreas is the intraductal tubulopapillary neoplasm. This type was recognised by ...
... colorectal cancer, kidney cancer, leukemia, liver cancer, lung cancer, lymphoma, pancreatic cancer, prostate cancer, skin ... They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... This group includes many of the most common cancers and include nearly all those in the breast, prostate, lung, pancreas and ... colorectal cancer and stomach cancer. In females, the most common types are breast cancer, colorectal cancer, lung cancer ...
... may increase the risk of colorectal, breast, ovarian, pancreas, brain, lung, cervical, and prostate cancers. ... especially liver and kidneys, eggs, and some seafood. Avocado, beetroot, spinach, liver, yeast, ... Folate deficiency hinders DNA synthesis and cell division, affecting hematopoietic cells and neoplasms the most because of ... August 1945). "Synthesis of a Compound Identical with the L. Casei Factor Isolated from Liver". Science. 102 (2644): 227-8. ...
"CD133 expression pattern distinguishes intraductal papillary mucinous neoplasms from ductal adenocarcinomas of the pancreas". ... and CD166 in colorectal cancer". Cancer Invest. 27 (8): 844-50. doi:10.1080/07357900902744502. PMID 19626493. Yeh CT, Kuo CJ, ... "Characterization of CD133+ parenchymal cells in the liver: Histology and culture". World J. Gastroenterol. 15 (39): 4896-906. ... Pancreas. 38 (8): e207-14. doi:10.1097/MPA.0b013e3181bb5037. PMID 19786935. Bertolini G, Roz L, Perego P, Tortoreto M, ...
Malignancies associated with these effects include gastric, colorectal, lung, bladder, and thyroid cancers, as well as squamous ... The World Health Organization classifies these disorders into a) Myeloid and lymphoid neoplasms with eosinophilia and ... Other examples of organ-restricted hepereosinophilia include those involving the heart, kidney, liver, colon, pulmonary pleurae ... and pancreas, respectively) plus retroperitoneal fibrosis. Less commonly, almost any other organ or tissue except joints and ...
Index of oncology articles
... liver cancer) - liver metastases - liver scan - LMB-1 immunotoxin - LMB-2 immunotoxin - LMB-7 immunotoxin - LMB-9 immunotoxin ... Colorectal cancer (colon cancer) - colon polyp - colonoscope - colonoscopy - colony-stimulating factor - colorectal - ... exocrine pancreas cell - expanded access trial - extensive-stage small cell lung cancer - external radiation - external-beam ... neoplasm - nephrotomogram - nephrotoxic - nephroureterectomy - nerve block - nerve grafting - nerve-sparing radical ...
Overall, the GI tract and the accessory organs of digestion (pancreas, liver, gall bladder) are responsible for more cancers ... hereditary nonpolyposis colorectal cancer or familial adenomatous polyposis. Colorectal cancer can be detected through the ... from patients who had never had a gastric malignant neoplasm), non-tumor tissue adjacent to a gastric cancer, and gastric ... Liver cancer may bring about yellowing of the skin and eyes (jaundice), itching (pruritus), or cause a buildup of fluid in the ...
... may increase the risk of colorectal, breast, ovarian, pancreas, brain, lung, cervical, and prostate cancers. Other studies ... Avocado, beetroot, spinach, liver, yeast, asparagus, and Brussels sprouts are among the foods with the highest levels of folate ... affecting hematopoietic cells and neoplasms the most because of their greater frequency of cell division. RNA transcription, ... Folates occur naturally in many foods especially dark green leafy vegetables and liver. "Folate" is the term used to name the ...
LKB1, wolna encyklopedia
STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. „Am J Pathol". 159. 6, ... Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors. „Cancer Res". 58. 10, s. 2087-90, 1998. PMID: ... Sirolimus amelioration of clinical symptoms of recurrent lymphangioleiomyomatosis after living-donor lobar lung transplantation ... Hereditary polyposis syndromes and hereditary non-polyposis colorectal cancer. „Best Pract Res Clin Gastroenterol". 17. 2, s. ...
胰臟癌 - 維基百科，自由的百科全書
Islet Cell Tumors of the Pancreas / Endocrine Neoplasms of the Pancreas. The Sol Goldman Pancreas Cancer Research Center. Johns ... ENETS Consensus Guidelines for the management of patients with liver and other distant metastases from neuroendocrine neoplasms ... 大腸息肉（英語：colorectal polyp）： 珀茨－傑格斯症候群 ... 腫瘤：內分泌腺腫瘤(C73-C75/D34-D35、193-194/226-227（英語：List of ICD-9 codes 140-239: neoplasms#Malignant neoplasm of other
List of cancer types
For example, cancers of the liver parenchyma arising from malignant epithelial cells is called hepatocarcinoma, while a ... Nearly all cancers developing in the breast, prostate, lung, pancreas, and colon are carcinomas. ... Multiple myeloma/plasma cell neoplasm. *Myelodysplastic syndromes. *Mucosa-associated lymphoid tissue lymphoma ... malignancy arising from primitive liver precursor cells is called a hepatoblastoma, and a cancer arising from fat cells is ...
Pancreas. *exocrine pancreas: Adenocarcinoma. *Pancreatic ductal carcinoma. *cystic neoplasms: Serous microcystic adenoma ... colorectal polyp: Peutz-Jeghers syndrome. *Juvenile polyposis syndrome. *Familial adenomatous polyposis/Gardner's syndrome ... Liver. *malignant: Hepatocellular carcinoma *Fibrolamellar. *Hepatoblastoma. *benign: Hepatocellular adenoma. *Cavernous ...
Philip J. Gold, M.D. | Seattle, WA
Pancreas Tail Cancer. *Pancreatic Mass. *Personal History Of Malignant Neoplasm Of Liver ... A Phase II study of Capecitabine, Oxaliplatin, Bevacizumab and Cetuximab in the Treatment of Metastatic Colorectal Cancer. ... Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. ... Phase II trial of romidepsin (NSC-630176) in previously treated colorectal cancer patients with advanced disease: a Southwest ...
CAR-T Hepatic Artery Infusions or Pancreatic Venous Infusions for CEA-Expressing Liver Metastases or Pancreas Cancer - Full...
Neoplasm Metastasis. Neoplasms, Second Primary. Liver Neoplasms. Pancreatic Neoplasms. Neoplastic Processes. Neoplasms. ... Colorectal Cancer. Liver Metastases. Breast Cancer. Gastric Cancer. Pancreas Cancer. Carcinoembryonic antigen. CAR-T. ... Digestive System Neoplasms. Neoplasms by Site. Digestive System Diseases. Liver Diseases. Endocrine Gland Neoplasms. Pancreatic ... CAR-T Hepatic Artery Infusions or Pancreatic Venous Infusions for CEA-Expressing Liver Metastases or Pancreas Cancer (HITM-SURE ...
The majority of malignant neoplasms located in the liver are metastases originating from primary tumor sites in other organs, ... Interestingly, this indicated that the closer the primary tumor site is located to the pancreas, the more likely a positive ... Hepatocellular carcinoma or hepatic metastasis from primaries such as pulmonary adenocarcinoma, colorectal adenocarcinoma, and ... nontumorous liver tissue. PODXL-1. podocalyxin-like protein 1. ROC. receiver operating characteristics. TGF. transforming ...
Case Reports in Gastroenterology
Inflammatory Pseudotumor of the Pancreas Mimicking a Pancreatic Neoplasm. A 78-year-old woman was admitted to our hospital with ... Synchronous Resection of Colon Adenocarcinoma and Bisegmentectomy of Liver Metastases. Colorectal cancer is one of the main ... Challenges Associated with Colorectal Cancer in Pregnancy. We present a case of colorectal cancer in a young multiparous female ... Pulmonary Embolism in a Donor of Living Donor Liver Transplantation. Pulmonary embolism (PE) is a rare but potentially fatal ...
Significance of Amphiregulin (AREG) for the Outcome of Low and High Grade Astrocytoma Patients
These data are contrary to the data found in other neoplasms including colon, breast, lung, liver, ovary, pancreas, prostate, ... Association of CpG island methylator phenotype and EREG/AREG methylation and expression in colorectal cancer. Br J Cancer. 2016 ... AREG was found to be up-regulated in a broad diversity of neoplasms suchlike lung , colon and stomach [12,13], pancreas [14 ... Li X-D, Miao S-Y, Wang G-L, Yang L, Shu Y-Q, Yin Y-M. Amphiregulin and epiregulin expression in colorectal carcinoma and the ...
Investigation of human papillomavirus DNA in colorectal carcinomas and adenomas | SpringerLink
Surgical pathology of the GI tract, liver, biliary tract, and pancreas. Philadelphia: Elsevier; 2004. p. 441-72.Google Scholar ... Kirgan D, Manalo P, Hall M, McGregor B. Association of human papillomavirus and colon neoplasms. Arch Surg. 1990;125(7):862-5. ... Colorectal papillomavirus infection in patients with colorectal cancer. Clin Cancer Res. 2005;11(8):2862-7.PubMedCrossRefGoogle ... Molecular biology of colorectal cancer. Curr Probl Cancer. 1997;21(5):233-300.PubMedCrossRefGoogle Scholar ...
Leser-Trélat sign - Wikipedia
Peter J. O'Dwyer, MD profile | PennMedicine.org
Hereditary Nonpolyposis Colorectal Cancer * Immunotherapy * Insulinoma * Liver Cancer * Malignant Neoplasm of Pancreatic Duct ... Carcinoid Tumor of Pancreas * Carcinoid Tumors * Colon Cancer Chemotherapy * Colorectal Cancer * Cystadenoma of Pancreas ... ODwyer PJ, Johnson SW: Current status of oxaliplatin in colorectal cancer Semin Oncol 30 (3 Supp 6): 78-87,2003. ... 2nd International Workshop on Targeted Therapy in Colorectal Cancer, * 3rd International Pharmacodynamics Workshop, Tidewater, ...
Kim A. Reiss Binder, MD profile | PennMedicine.org
Hereditary Nonpolyposis Colorectal Cancer * Immunotherapy * Insulinoma * Liver Cancer * Malignant Neoplasm of Pancreatic Duct ... Carcinoid Tumor of Pancreas * Carcinoid Tumors * Colon Cancer Chemotherapy * Colorectal Cancer * Cystadenoma of Pancreas ... Lung Metastasis Predicts Better Prognosis in Metastatic Colorectal Cancer with Mutated KRAS Clinical Colorectal Cancer : 2019. ... Post-Operative Radiation for Pathologic Stage T4 Colon Cancers Receiving Adjuvant Chemotherapy Clinical Colorectal Cancer : ...
CCKBR | Cancer Genetics Web
Colorectal Cancer. CCKBR and Colonic Neoplasms. View Publications. 0. Pancreatic Cancer. CCKBR and Pancreatic Cancer. View ... The CCKBR/GR expression was detected in 58.2% of SC, 48.0% of BGD, 18.4% of PC, and 60.0% of normal pancreas tissue samples. ... Am J Physiol Gastrointest Liver Physiol. 2012; 302(11):G1244-52 [PubMed] Article available free on PMC after 01/05/2017 Related ... RESULT: CCKAR expression was detected in 18.2% of SC, 20% of BGD, 65.8% of PC, and 30.0% of normal pancreas tissue samples. ...
Aging | Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node...
CD44 and Cyclin-D1 expression in primary tumors and in their corresponding lymph node and liver metastases (n=294). Finally, ... Colorectal cancer (CRC) is a major health problem in elderly people because of its high incidence and high mortality rate. ... Odze and Goldblum Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas. Third Edit. Philadelphia, USA: ... Chapter 27-Epithelial Neoplasms of the Large Intestine. In: Goldblum JR, Odze RD. ...
Clifford Suhyun Cho MD | Michigan Medicine
... liver cancer, pancreatic cystic neoplasms, retroperitoneal sarcoma, gastric cancer, peritoneal malignancies, and complex ... Pancreas cancer, liver cancer, pancreatic cystic neoplasms, retroperitoneal sarcoma, gastric cancer, peritoneal malignancies, ... Michigan Medicine Multidisciplinary Colorectal Cancer Clinic , Rogel Cancer Center See map: Google Maps ... Michigan Medicine Multidisciplinary Liver Clinic , Rogel Cancer Center See map: Google Maps ...
Malignant Liver Neoplasms | Abdominal Key
... primary liver tumors remain the second leading cause of death from cancer in males and the sixth leading cause of death from ... primary liver tumors will be diagnosed in approximately 42,220 new patients in the United States, and approximately 30,200 ... colorectal, pancreas, and liver cancers. Women with a BMI of 35 to 40 kg/m2 had almost twice the mortality rate from liver ... The 2 most common hepatic neoplasms are hepatocellular carcinoma (HCC), which accounts for more than 75% of primary liver ...
CTLA-4 polymorphisms and predisposition to digestive system malignancies: a meta-analysis of 31 published studies | World...
This meta-analysis suggested that rs231775 polymorphism was associated with predisposition to colorectal cancer and pancreatic ... for rs3087243 polymorphism among patients with liver cancer and controls, and for rs733618 polymorphism among patients with ... rs3087243 polymorphism was associated with predisposition to liver cancer, and rs733618 polymorphism was associated with ... Moreover, genotypic distribution differences were also observed for rs231775 polymorphism among patients with colorectal cancer ...
Colorectal Screening: Out-of-Pocket Costs | The Community Guide
Task Force finds more evidence needed on effectiveness of reducing out-of-pocket costs to increase colorectal cancer screening ... duodenal neoplasms/ or exp *ileal neoplasms/ or exp *jejunal neoplasms/ or exp *stomach neoplasms/ or exp *liver neoplasms/ or ... or bone or biliary tract or esophageal or cecal or duodenal or ileal or jejunal or stomach or liver or pancreas* or peritone* ... NEOPLASMS/pc or exp CECAL NEOPLASMS/pc or exp COLORECTAL NEOPLASMS/pc or exp COLONIC NEOPLASMS/pc or exp SIGMOID NEOPLASMS/pc ...
GI Board Review OnDemand 2018 - updatemedicine
Drug Induced Liver Injury. Cystic Neoplasm of the Pancreas. Constipation, Pelvic Floor, Womens Disorders. Colon Cancer ... Interpretation of Liver Tests. Imaging of the Biliary Tract and Pancreas. Hereditary Colorectal Cancer Syndromes. ... Liver Transplantation. Liver Histopathology. Liver Diseases of Pregnancy. listname.bat. Liver Board Review Questions Part 2. ... Anatomy and Physiology of the Pancreas. Alcoholic and Non-Alcoholic Fatty Liver Disease. Acute Pancreatitis. ABIMMOC Update GI ...
Darren Carpizo - Research Output - Rutgers, The State University of New Jersey
Current management of cystic neoplasms of the pancreas. Carpizo, D. R., Allen, P. J. & Brennan, M. F., Oct 2008, In : Surgeon. ... Liver resection for metastatic colorectal cancer in the presence of extrahepatic disease. Carpizo, D. & DAngelica, M., Sep 1 ... Liver resection for metastatic colorectal cancer in the presence of extrahepatic disease. Carpizo, D. & DAngelica, M., Aug 1 ... Metastatic Liver Cancer: Treatment: Surgical therapy for hepatic colorectal metastases. Carpizo, D. & Fong, Y., Jan 14 2009, ...
Textbook of Surgery, 3rd Edition | Surgery & Surgical Specialties | Medicine, Nursing & Dentistry | Subjects | Wiley
Joe J Tjandra, Colorectal and Breast Surgeon and Associate Professor of Surgery, Royal Melbourne Hospital, University of ... 36 Endocrine tumours of the pancreas.. Head and Neck Surgery.. 37 Ocular injury and infection. ... 13 Gastric neoplasms.. Hepatopancreaticobiliary.. 14 Gall stones.. 15 Benign and malignant diseases. ... 16 Infections of the liver.. 17 Pancreatitis.. 18 Portal hypertension.. Lower Gastrointestinal Surgery. ...
Sonali Patel | Summit Medical Group
Dr. Frederick K Shieh, MD | Summit Medical Group
... disease Liver disease Neoplasm nonalcoholic fatty liver disease Non-cancerous tumor nutritional deficiency Obesity Pancreas ... Colon and rectal bleeding colon bleeding Colon Bleeding Colon cancer Colonoscopy Colon polyps colon screening colorectal cancer ... liver, pancreas and bile duct, biliary diseases, cancer screening and management, esophageal disease and gastrointestinal ... and Pancreas. Dr. Shieh is a member of the American Society for Gastrointestinal Endoscopy, the American Gastroenterological ...
Surgical treatment of solid pseudopapillary neoplasms of the pancreas and risk factors for malignancy - British Journal of...
Quality of life from a randomized trial of laparoscopic or open liver resection for colorectal liver metastases. BJS 2019; 106 ... Meta‐analysis of the association between primary tumour location and prognosis after surgical resection of colorectal liver ... Surgical treatment of solid pseudopapillary neoplasms of the pancreas and risk factors for malignancy. BJS 2014; 101: 1266-1271 ... Secondary technical resectability of colorectal cancer liver metastases after chemotherapy with or without selective internal ...
Synapse - Synchronous epithelial and neuroendocrine cancers of the pancreas: Case series of a rare occurrence
... liver biopsy; gallstone; neoplasms, multiple primary; hepatic artery; endoscopic echography; neuroendocrine tumors; ... colorectal cancer and gastric cancer. Genetic analysis of such tumors has suggested a common multipotent progenitor stem cell ... liver metastasis; pancreas tumor; pancreas adenocarcinoma; jaundice; liver resection; stent; octreotide; aspiration biopsy; ... Mixed Adenoneuroendocrine Carcinoma Of The Pancreas. Pancreatic Neuroendocrine Neoplasms: Practical Approach to Diagnosis, ...
Application # 2017/0102386. Method for identifying and obtaining activated T-cells that have a demethylated Foxp3 TSDR...
... colorectal neoplasms, liver neoplasms, pancreatic neoplasms, pituitary neoplasms, testicular neoplasms, orbital neoplasms, ... of the pancreas, of the liver, of the gall bladder and of the biliary tract, of the small bowel, colon and rectal carcinomas ... neoplasms (for example bone neoplasms, breast neoplasms, neoplasms of the digestive system, ... neoplasms of the head and neck, of the central nervous system, neoplasms of the hearing organ, of the pelvis, of the ...
BIRC5 sirna product blog
Colorectal Neoplasms, Liver Diseases, Liver Neoplasms, Lung Neoplasms, Neoplasm Metastasis, Neoplasms, Experimental are some of ... Dorsal Root Ganglion, Embryonic Tissue, Pancreas, Prostate, Uncharacterized Tissue tissues are correlated with this protein. ... Adenocarcinoma, Breast Neoplasms, Carcinoma, Hepatocellular, Carcinoma, Small Cell, ...
REG4 elisa kit product blog
Carcinoma, Colitis, Colonic Neoplasms, Colorectal Neoplasms, Gastrointestinal Diseases, Inflammation, Liver Neoplasms, Neoplasm ... Ascites, Intestine, Lung, Mammary Gland, Ovary, Pancreas, Prostate, Stomach tissues are correlated with this protein. ... Metastasis, Prostatic Neoplasms, Stomach Neoplasms are some of the diseases may be linked to Porcine REG4 (Regenerating Islet ...
Delayed tumour enhancement on gadoxetate-enhanced MRI is associated with overall survival in patients with colorectal liver...
... enhancement on preoperative delayed-phase gadoxetate-enhanced MRI can predict long-term survival in patients with colorectal ... Colorectal cancer Neoplasm Metastases Gadolinium Survival Abbreviations. CEA. Carcinoembryonic antigen. CRCLM. Colorectal liver ... number of liver metastases, size of the liver metastases, time from diagnosis of primary to diagnosis of liver metastases, node ... Biopsy of resectable colorectal liver metastases causes tumour dissemination and adversely affects survival after liver ...
colorectal neoplasm | Gut
Colorectal cancer screening: a global overview of existing programmes Eline H Schreuders, Arlinda Ruco, Linda Rabeneck, Robert ... Adolescent body mass index and erythrocyte sedimentation rate in relation to colorectal cancer risk Elizabeth D Kantor, Ruzan ... Prospective evaluation of methylated SEPT9 in plasma for detection of asymptomatic colorectal cancer Timothy Robert Church, ... EGFR signalling and oncogenic pathway signature in colorectal cancer Ibrahim Halil Sahin, Ahmet Afsin Oktay ...
Navesh Sharma, DO, PhD - Penn State Cancer Institute
... and younger patients with unresectable liver-dominant colorectal cancer, Clinical Colorectal Cancer, vol. 15, no. 2, pp. 141- ... Selective Internal Radiation Therapy in the Multidisciplinary Management of Liver Metastases From Colorectal Carcinoma, ... tumor volume as a prognostic factor in metastatic colorectal cancer treated with selective internal radiation to the liver ... selective internal radiotherapy plus chemotherapy versus chemotherapy alone in patients with liver metastases from colorectal ...
ICD-10 Diagnosis Code Z80.0 Family history of malignant neoplasm of digestive organs
Family history of malignant neoplasm of liver *Family history of malignant neoplasm of pancreas ... Family history of colorectal cancer *Family history of disorder of pancreas *Family history of hepatoma ... Long Description: Family history of malignant neoplasm of digestive organs This is the 2018 version of the ICD-10-CM diagnosis ... Also called: Carcinoma, Malignancy, Neoplasms, Tumor. Cancer begins in your cells, which are the building blocks of your body. ...
Burden of disease due to cancer in Spain | BMC Public Health | Full Text
Lung, colorectal and breast cancers are responsible for the highest number of DALYs in Spain. Even if the burden of disease due ... Of the total, 51% corresponded to lung, colorectal, breast, stomach and prostate cancers. Mortality (84% of DALYs) predominated ... along with neoplasms of stomach, prostate, bladder, liver, pancreas and leukaemias account for more than two thirds of the ... Malignant tumours of liver, kidney, stomach and brain also cause a greater BoD in men. In contrast, neoplasms of breast, ...
MetastasesCarcinomaTumorsCancersGastric cancerUnderlying colorectal cancerResectionMalignancyMetastatic colorectal cancerHepaticIntraductalAdenocarcinomaNeuroendocrine2018MalignanciesOncologyCystic neoplasms of the liverDiseasesStomach NeoplasmsChemotherapySurvivalPolypsTumor cellsCirrhosisSurgeryScreening for colorectal cancerCarcinomasBiliary Tract and PancreasRectalAcuteWhipple
- This is an open label, fixed dose, phase Ib trial of anti-CEA CAR-T cell infusions delivered via the hepatic artery or splenic vein using the Surefire Infusion System (SIS) for patients with CEA-expressing liver metastases or pancreas cancer. (clinicaltrials.gov)
- Patients with CEA+ liver metastases who exhibit in-liver control following CAR-T therapy who also have CEA+ primary pancreatic tumors may be eligible to receive direct intrapancreatic CAR-T retrograde venous infusions. (clinicaltrials.gov)
- The majority of malignant neoplasms located in the liver are metastases originating from primary tumor sites in other organs, most commonly the colon or the pancreas ( 1 ). (mcponline.org)
- For primary cholangiocellular carcinoma (CCC) 1 and metastases of pancreatic ductal adenocarcinoma (PDAC), however, the distinction in a liver biopsy is basically an unsolvable task because of their high similarity. (mcponline.org)
- Solano-Iturri JD , Beitia M , Errarte P , Calvete-Candenas J , Etxezarraga MC , Loizate A , Echevarria E , Badiola I , Larrinaga G , . Altered expression of fibroblast activation protein-α (FAP) in colorectal adenoma-carcinoma sequence and in lymph node and liver metastases. (aging-us.com)
- In addition, FAP expression was analyzed individually and in combination with β-catenin (BCAT), CD44 and Cyclin-D1 expression in primary tumors and in their corresponding lymph node and liver metastases (n=294). (aging-us.com)
- Secondary technical resectability of colorectal cancer liver metastases after chemotherapy with or without selective internal radiotherapy in the randomized SIRFLOX trial. (bjs.co.uk)
- Meta‐analysis of the association between primary tumour location and prognosis after surgical resection of colorectal liver metastases. (bjs.co.uk)
- Quality of life from a randomized trial of laparoscopic or open liver resection for colorectal liver metastases. (bjs.co.uk)
- To determine whether tumour enhancement on preoperative delayed-phase gadoxetate-enhanced MRI can predict long-term survival in patients with colorectal liver metastases (CRCLM) post-hepatectomy. (springer.com)
- Most of the deaths are related to metastatic disease, with the liver being the most common site for metastases. (springer.com)
- With improvements in surgical techniques and systemic therapy in the last 2 decades, the survival for colorectal liver metastases (CRCLM) has significantly improved. (springer.com)
- Tchelebi, L & Sharma, N 2019, ' Selective Internal Radiation Therapy in the Multidisciplinary Management of Liver Metastases From Colorectal Carcinoma ', Seminars in Nuclear Medicine , vol. 49, no. 3, pp. 182-188. (psu.edu)
- See Cancer , Doubling time , Intraductal papillary-mucinous neoplasm of pancreas, Metastases, Papillary & solid neoplasm of pancreas. (thefreedictionary.com)
- Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing. (cdc.gov)
- Trends in Long-term Survival Following Liver Resection for Hepatic Colorectal Metastases Annals of Surgery. (jove.com)
- CT findings of colon cancer include focal lobulated soft tissue mass in the colon, localized thickening of greater than 5 mm of the bowel wall, irregular lumen surface, extension of linear soft tissue densities or discrete mass into pericolic fat or adjacent organs, regional adenopathy, and liver metastases. (uab.edu)
- Dr. Weiss' clinical interests also include colorectal metastases to the liver, hepatocellular carcinomas, intrahepatic cholangiocarcinomas, bile duct cancers (Klatskin tumors), intraductal papillary mucinous neoplasms of the pancreas, neuroendocrine tumors, and gallbladder cancers. (broadcastmed.net)
- It is expected that as many as 25% of patients with colorectal cancer will have liver metastases at presentation and 50% will have liver metastases develop metachronously. (cancernetwork.com)
- Patients with liver metastases from other solid tumors also are candidates for resection. (cancernetwork.com)
- Patients with Wilms' tumor are excellent candidates for resection of hepatic metastases, as are those with a solitary liver metastasis from renal cell carcinoma. (cancernetwork.com)
- Liver metastases from endocrine tumors rarely present with localized disease that can be completely resected, but if localized, surgical resection is the treatment of choice. (cancernetwork.com)
- CXCR4 Expression Predicts Patient Outcome and Recurrence Patterns after Hepatic Resection for Colorectal Liver Metastases. (utsouthwestern.edu)
- Overexpression of PRL-3 has been implicated in colorectal cancer metastases. (aacrjournals.org)
- In addition, PRL-3 is expected to be a promising biomarker for identifying colorectal cancer patients at high risk for distant metastases. (aacrjournals.org)
- In addition, not a few colorectal cancer patients suffer from the unexpected development of occult metastases, especially in the liver and lung, after the curative resection of their primary tumors. (aacrjournals.org)
- (3) performed global gene expression profiles using a serial analysis of gene expression approach and found that PRL-3 ( phosphatase of regenerating liver-3/PTP4A3 ) was frequently overexpressed in the liver metastases studied, but expressed at lower levels in primary tumors and normal colorectal epithelium. (aacrjournals.org)
- In this case, the patient was diagnosed with hepatocellular carcinoma more than 20 years after undergoing the Fontan procedure and was a candidate for combined heart-liver transplant. (medworm.com)
- One hundred and six colorectal carcinomas and 62 adenomas were screened by nested polymerase chain reaction (PCR) for HPV DNA with a control group of 49 cervical tissues with invasive cervical carcinoma and cervical intraepithelial neoplasia (CIN). (springer.com)
- Impact of postoperative infective complications on long‐term survival after liver resection for hepatocellular carcinoma. (bjs.co.uk)
- Prognostic Implications of Mucinous Differentiation in Metastatic Colorectal Carcinoma Can Be Explained by Distinct Molecular and Clinicopathologic Characteristics. (cdc.gov)
- Pancreas lipiodol embolism induced acute necrotizing pancreatitis following transcatheter arterial chemoembolization for hepatocellular carcinoma: A case report and literature review. (bioportfolio.com)
- The incidence of carcinoma of the pancreas is associated with a high mortality rate. (aacrjournals.org)
- The hepatocellular carcinoma program is administered by the Division of Liver Diseases and the Recanati Miller Transplant Institute. (mssm.edu)
- Invasive carcinoma arising in intraductal papillary mucinous neoplasms of the pancreas: a matched control study with conventional pancreatic ductal adenocarcinoma. (utsouthwestern.edu)
- In conjunction with abdominal ultrasonography, it is recommended that alphafetoprotein (AFP) be measured at six-monthly intervals in patients at high risk for hepatocellular carcinoma (especially those with liver cirrhosis related to hepatitis B or hepatitis C). A raised AFP is found in 80% of patients with hepatocellular carcinoma and in 40% of these patients, the AFP exceeds 1000 ng/mL. (healthxchange.com.sg)
- giant cell carcinoma a poorly differentiated, highly malignant, epithelial neoplasm containing many large multinucleated tumor cells, such as occurs in the lungs. (thefreedictionary.com)
- hepatocellular carcinoma primary carcinoma of the liver cells with hepatomegaly, jaundice, hemoperitoneum, and other symptoms of the presence of an abdominal mass. (thefreedictionary.com)
- Dr. Gold's clinical investigations on GI tumors, and particularly colorectal cancer treatment, can be found in peer-reviewed publications like the Journal of Clinical Oncology, Seminars in Oncology, and Cancer Investigation. (swedish.org)
- We conclude that ANXA1 and ANXA10 are promising biomarker candidates with high diagnostic values for the differential diagnosis of intrahepatic CCC and metastatic liver tumors deriving from PDAC. (mcponline.org)
- A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. (cancerindex.org)
- In 2018, primary liver tumors will be diagnosed in approximately 42,220 new patients in the United States, and approximately 30,200 individuals will die from this disease. (abdominalkey.com)
- 1 Worldwide, primary liver tumors remain the second leading cause of death from cancer in males and the sixth leading cause of death from cancer in females. (abdominalkey.com)
- KRAS and PIK3CA mutation frequencies in patient-derived xenograft models of pancreatic and colorectal cancer are reflective of patient tumors and stable across passages. (cdc.gov)
- From published case series, it appears that these tumors have a better prognosis than adenocarcinomas of the pancreas. (knowcancer.com)
- The Gastrointestinal Cancer Research Program in the Division of Gastroenterology covers cancers of all digestive organs, with a concentration in three main areas: Colorectal cancer (CRC), neuroendocrine tumors (NETs) and familial pancreatic cancer. (mssm.edu)
- In addition, the group is also very active in the surgical treatment of liver tumors, bile duct problems, pancreatic cancer, chronic pancreatitis, and other hepatobiliary diseases. (ohsu.edu)
- Keutgen XM, Schadde E, Pommier RF, Halfdanarson TR, Howe JR, Kebebew E. Metastatic neuroendocrine tumors of the gastrointestinal tract and pancreas: A surgeon's plea to centering attention on the liver. (uchicago.edu)
- ABSTRACT: Primary and metastatic liver tumors continue to be a significant health problem in the United States. (cancernetwork.com)
- Other rare primary tumors also are seen in the liver. (cancernetwork.com)
- Intrahepatic cholangiocarcinomas represent less than 0.5% of liver tumors. (cancernetwork.com)
- Specifically, Dr. House's clinical interests are focused on surgical oncology including the management of primary and secondary hepatic neoplasms, bile duct tumors, benign and malignant diseases of the pancreas, gastric cancer, and sarcoma. (iuhealth.org)
- Lung, colorectal and breast cancers are responsible for the highest number of DALYs in Spain. (biomedcentral.com)
- Gastrointestinal Neoplasms refers to the group of cancers that affect the digestive system which includes cancers of the oesophagus, gallbladder, liver, pancreas, stomach, small intestine, bowel and anus. (gastroconferences.com)
- Less strong direct relations were observed for cancers of the stomach, colon and rectum, liver, breast and ovary. (nih.gov)
- No significant nor consistent relation was observed for cancers of the pancreas, lung, prostate or bladder. (nih.gov)
- Allowance for tobacco appreciably modified the relations with laryngeal, lung and bladder cancers, but not those with oral, oesophageal or colorectal cancers. (nih.gov)
- Areas of active research include the multidisciplinary treatment of pancreatic neuroendocrine cancers, technical aspects of minimally invasive pancreatic and liver surgery, and trends in the management of hepatobiliary cancers in California. (stanford.edu)
- These chemotherapy drugs are commonly used to treat more common pancreatic and colorectal cancers. (knowcancer.com)
- His research focuses predominantly on pre-neoplastic lesions and early cancers of the gut and particularly Barrett's esophagus-related neoplasms and gastric cancer. (moffitt.org)
- In 1995, the estimated incidence of primary liver and biliary cancers was 18,500 cases in the United States, with 7,800 estimated deaths from these cancers. (cancernetwork.com)
- Elevated levels of CA19-9, an intracellular adhesion molecule, occur primarily in patients with pancreatic and biliary tract cancers, but may be raised in colorectal, gastric, hepatocellular, oesophageal and ovarian cancers. (healthxchange.com.sg)
- Moreover, genotypic distribution differences were also observed for rs231775 polymorphism among patients with colorectal cancer/pancreatic cancer and controls, for rs4553808 and rs5742909 polymorphisms among patients with gastric cancer and controls, for rs3087243 polymorphism among patients with liver cancer and controls, and for rs733618 polymorphism among patients with colorectal cancer and controls in pooled meta-analyses. (biomedcentral.com)
- This meta-analysis suggested that rs231775 polymorphism was associated with predisposition to colorectal cancer and pancreatic cancer, rs4553808 and rs5742909 polymorphisms were associated with predisposition to gastric cancer, rs3087243 polymorphism was associated with predisposition to liver cancer, and rs733618 polymorphism was associated with predisposition to colorectal cancer. (biomedcentral.com)
- 4,5 Systematic reviews have indicated that CD133 is a prognostic factor in colorectal cancer (CRC) 12 and gastric cancer. (touchoncology.com)
- Few studies to date have evaluated gastric cancer(GC)-related malignant neoplasm family history (MN-FH), and their findings have been largely inconsistent. (biomedcentral.com)
Underlying colorectal cancer1
- A total of five patients underwent en bloc resection of adjacent structures, including two with portal vein involvement. (bjs.co.uk)
- Multicentre analysis of the learning curve for laparoscopic liver resection of the posterosuperior segments. (bjs.co.uk)
- Sixty-five patients who received a preoperative gadoxetate-enhanced MRI prior to liver resection for CRCLM from January 1, 2010, to December 31, 2012, were included in this retrospective study. (springer.com)
- This subspecialty of general surgery treats a variety of conditions affecting the liver, pancreas, gallbladder and spleen through procedures including liver resection, gallbladder removal, and the Whipple procedure. (healthgrades.com)
- Whereas laparoscopic procedures involving resection of the head of the pancreas (pancreatoduodenectomy (PD), total PD) still represent a major challenge even for experienced laparoscopic surgeons, enucleations/ atypical resections are increasingly performed worldwide [3-5, 7- (termedia.pl)
- Hepatic resection or, in selected cases, transplantation are the only curative therapies for patients with resectable disease confined to the liver. (cancernetwork.com)
- Three conditions preclude liver resection: an unacceptable risk based on the degree of cirrhosis, evidence of extrahepatic disease, and tumor spread within the liver that prevents the attainment of clear surgical margins. (cancernetwork.com)
- Surgical resection also is the only potential curative treatment for metastatic cancer to the liver. (cancernetwork.com)
- 2005, Two-stage laparoscopic resection of colon cancer and metastatic liver tumor. (oita-u.ac.jp)
- In patients with primary hepatic malignancies, the malignancy itself and any underlying liver disease must be considered as 2 separate but interconnected pathologic processes. (abdominalkey.com)
- The aim of this study was to identify clinical predictors of malignancy and surgical strategies for pancreatic solid pseudopapillary neoplasm ( SPN ) by analysis of surgical outcomes at a single institution. (bjs.co.uk)
Metastatic colorectal cancer2
- SIRFLOX and FOXFIRE Global Trial Investigators 2018, ' Effect of Primary Tumor Side on Survival Outcomes in Untreated Patients With Metastatic Colorectal Cancer When Selective Internal Radiation Therapy Is Added to Chemotherapy: Combined Analysis of Two Randomized Controlled Studies ', Clinical Colorectal Cancer , vol. 17, no. 4, pp. e617-e629. (psu.edu)
- Without surgery, the median survival of patients with metastatic colorectal cancer confined to the liver is measured in months, with the majority of patients dying within a year ( Table 1 ) [4- (cancernetwork.com)
- The remaining primary hepatic neoplasms are hepatic angiosarcoma, epithelioid hemangioendothelioma, and hepatic lymphoma. (abdominalkey.com)
- Discuss the updated classification of benign and malignant hepatic neoplasm. (cloud-cme.com)
- The presence of compromised liver function, thrombocytopenia, and coagulopathy with increased intraoperative blood loss can lead to postoperative hepatic decompensation and failure. (cancernetwork.com)
- Validation of a nomogram to predict the risk of cancer in patients with intraductal papillary mucinous neoplasm and main duct dilatation of 10 mm or less. (bjs.co.uk)
- GNAS but Not Extended RAS Mutations Spectrum are Associated with a Better Prognosis in Intraductal Pancreatic Mucinous Neoplasms. (cdc.gov)
- Loss of PTEN expression is associated with poor prognosis in patients with intraductal papillary mucinous neoplasms of the pancreas. (cdc.gov)
- Different subtypes of intraductal papillary mucinous neoplasm in the pancreas have distinct pathways to pancreatic cancer progression. (cdc.gov)
- Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas. (cdc.gov)
- Prevalence of Extrapancreatic Malignancies Among Patients With Intraductal Papillary Mucinous Neoplasms of the Pancreas. (nih.gov)
- Comparative clinicopathological study of biliary intraductal papillary neoplasms and papillary cholangiocarcinomas. (cdc.gov)
- Prognosis of invasive intraductal papillary mucinous neoplasms of the pancreas. (utsouthwestern.edu)
- Colorectal adenocarcinoma is one of the most common neoplasms encountered in the affluent countries of the Western world. (uab.edu)
- Carcinoembryonic antigen (CEA) is a glycoprotein, which is present in normal mucosal cells but increased amounts are associated with adenocarcinoma, especially colorectal cancer. (healthxchange.com.sg)
- First addressed are the most common gastric and small bowel malignancies - adenocarcinoma - before the book progresses to a thorough discussion of some complexities of colorectal cancer. (future-science-group.com)
- Diagnosed with colorectal cancer Kimberly "Kim" Parker, a former college administrator, took the advice of others and became a patient of Dr. Michael House who specializes in surgical oncology. (iuhealth.org)
- 2005, Randomized controlled trial to evaluate laparoscopic surgery for colorectal cancer: Japan clinical oncology group study JCOG 0404. (oita-u.ac.jp)
Cystic neoplasms of the liver5
- Mucinous cystic neoplasms of the liver and pancreas: relationship between KRAS driver mutations and disease progression. (cdc.gov)
- Mucinous cystic neoplasms of the liver and extrahepatic biliary tree have recently been re-defined by WHO as epithelial cystic tumours with ovarian-type mesenchymal stroma. (intechopen.com)
- Mucinous cystic neoplasms of the liver [ 1 ], formerly known as bile duct/biliary cystadenoma and biliary cystadenocarcinoma [ 2 ], represent an enigmatic entity, characterised by unknown origin and peculiar morphology including the presence of ovarian-type stroma. (intechopen.com)
- To enhance the knowledge of medical society on the mucinous cystic neoplasms of the liver, here we aim to summarise contemporary data on these tumours, including the current definition and classification [ 1 ], the recent molecular genetic findings [ 3 , 4 ] as well as the practical issues of clinical presentation, diagnostic approach, treatment and prognosis. (intechopen.com)
- Currently, mucinous cystic neoplasms of the liver are defined as epithelial cystic tumours associated with ovarian-type mesenchymal stroma. (intechopen.com)
- Frederick K. Shieh, MD, specializes in gastroenterology with a special interest in advanced therapeutic endoscopy, disorders of the gastrointestinal tract, liver, pancreas and bile duct, biliary diseases, cancer screening and management, esophageal disease and gastrointestinal bleeding. (summitmedicalgroup.com)
- Table 1 shows that diseases of the circulatory system and cancer (malignant neoplasms) were, by far, the leading causes of death in the EU. (europa.eu)
- Matthew Weiss, MD, FACS, specializes in surgery for pancreatic and liver cancer, as well as benign hepatopancreatobiliary diseases, including cystic lesions of the pancreas. (broadcastmed.net)
- OHSU physicians utilize several endoscopic (internal seeing) methods for treating and evaluating liver, pancreatic and biliary diseases. (ohsu.edu)
- Stomach Neoplasms" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- This graph shows the total number of publications written about "Stomach Neoplasms" by people in this website by year, and whether "Stomach Neoplasms" was a major or minor topic of these publications. (uchicago.edu)
- Below are the most recent publications written about "Stomach Neoplasms" by people in Profiles. (uchicago.edu)
- The increase in survival in many malignant neoplasms means that, in addition to mortality, it is increasingly necessary to take into account the non-mortal consequences of disease (disability due to the disease itself or to treatment, and the worsening of the patient's quality of life). (biomedcentral.com)
- Predisposing factors for colorectal cancer include adenomatous polyps, inherited multiple polyposis syndromes, long-standing ulcerative colitis, close relatives with colon cancer, and a low fiber, high animal fat diet. (uab.edu)
- Develop a diagnostic approach to unusual/variant colorectal polyps. (cloud-cme.com)
- 4 The degree of liver change that results from hepatitis before development of HCC differs between hepatitis B and C. Among patients with hepatitis B, 20% of HCC cases develop before cirrhosis develops, whereas among patients with hepatitis C, HCC almost always arises in the background of significant cirrhosis and fibrosis. (abdominalkey.com)
- Other risk factors for HCC include environmental exposures, chronic disease processes, and genetic conditions that predispose patients to development of cirrhosis and/or chronic liver inflammation. (abdominalkey.com)
- Metabolism of alcohol occurs through oxidative processes, resulting in lipogenesis and fatty liver development that can progress to cirrhosis. (abdominalkey.com)
- A Randomized Control Trial of Thromboelastography-Guided Transfusion in Cirrhosis for High-Risk Invasive Liver-Related Procedures. (amedeo.com)
- Clinical Cirrhosis Dilemmas: Survey of Practice from the 7th International Coagulation in Liver Disease Conference. (amedeo.com)
- Portal Hypertension, Clinical and basic research on diagnosis and treatment of esophago-gastic varices as complications of the liver cirrhosis. (oita-u.ac.jp)
- He got the training in deceased donor liver transplant and HPB surgery in King's College Hospital, London (UK). (liverhelplineindia.com)
- He has been the Editorial board member of different journals like Archives of Organ Transplantation, Journal of Biological Research (Hong Kong), SM Journal of Gastroenterology & Hepatology, Journal of Gastroenterology, Liver & Pancreatic disease and Surgery . (liverhelplineindia.com)
- Dr. Sheppard has more experience with Transplant Surgery and Liver/Pancreas/Gallbadder/Spleen Surgery than other specialists in his area. (healthgrades.com)
- Transplant surgery is a subspecialty of general surgery that focuses on replacement of damaged or diseased organs with healthy donor organs and includes partial, single or multi-organ transplant, as well as living donor organ procurement. (healthgrades.com)
- Compare with other Liver/Pancreas/Gallbadder/Spleen Surgery specialists. (healthgrades.com)
- Comprehensive and complete, Blumgart's Surgery of the Liver, Pancreas and Biliary Tract - edited by Dr. William R. Jarnagin and a team of experts- delivers the comprehensive, cutting-edge guidance you need to achieve optimal outcomes in surgery of the liver, biliary tract, and pancreas. (elsevier.com)
- Prognostic Value of HMLH1 Methylation and Microsatellite Instability in Pancreatic Endocrine Neoplasms Surgery. (jove.com)
- Traditionally considered a difficult organ to approach surgically, owing to its retroperitoneal location, its connections with major vessels and the intrinsic characteristics of its parenchyma, the pancreas has been considered for years one of the "last frontiers" of laparoscopic surgery. (termedia.pl)
- His research interests include the examining the outcomes following the utilization of minimally invasive and robotic surgery in pancreatic and liver surgery. (broadcastmed.net)
- Dr. Winslow is MedStar's Regional Chief of Hepatopancreaticobiliary Surgery and a board-certified surgeon who specializes in the treatment of cancer of the liver, pancreas, gallbladder, and bile ducts, as well as benign conditions that affect these organs. (amazonaws.com)
- She is an experienced surgeon and performs minimally invasive and open surgery of the liver, biliary tree, and pancreas. (amazonaws.com)
- Her surgery resulted in a bile leak, and another spot of cancer was found on her liver that was removed during the procedure. (iuhealth.org)
Screening for colorectal cancer2
- The Community Preventive Services Task Force (CPSTF) finds insufficient evidence to determine the effectiveness of reducing out-of-pocket costs in increasing screening for colorectal cancer because no studies were identified. (thecommunityguide.org)
- While there is insufficient evidence to determine effectiveness of this intervention in increasing screening for colorectal cancer, consistently favorable results for interventions that reduce costs for breast cancer screening and several other preventive services suggest that such interventions are likely to be effective for increasing colorectal cancer screening as well. (thecommunityguide.org)
- The aim of the study was to evaluate the presence of human papillomavirus DNA in colorectal carcinomas and adenomas. (springer.com)
- In the study group, we did not find HPV DNA positivity in any of all the colorectal carcinomas and adenomas. (springer.com)
- These results indicated that there was no correlation between HPV infection and colorectal carcinomas and adenomas. (springer.com)
- 85% of renal neoplasms are renal cell carcinomas, most commonly occurring in men, at ages 50-70, and usually involving one kidney. (uab.edu)
Biliary Tract and Pancreas1
- He's experienced at performing robotic whipple, robotic distal pancreatectomy, robotic colectomy and robotic liver resections. (moffitt.org)
- Because of a relatively large size at the time of presentation (average diameter of 5 cm) and common location within the head of the pancreas, the Whipple procedure (pancreaticoduodenectomy) serves as the predominant modality for curative and palliative surgical approaches. (jove.com)