A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.
The sudden collapse and disappearance or diminution of a colony of organisms.
Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.
Insects of the family Formicidae, very common and widespread, probably the most successful of all the insect groups. All ants are social insects, and most colonies contain three castes, queens, males, and workers. Their habits are often very elaborate and a great many studies have been made of ant behavior. Ants produce a number of secretions that function in offense, defense, and communication. (From Borror, et al., An Introduction to the Study of Insects, 4th ed, p676)
A complex sulfated polymer of galactose units, extracted from Gelidium cartilagineum, Gracilaria confervoides, and related red algae. It is used as a gel in the preparation of solid culture media for microorganisms, as a bulk laxative, in making emulsions, and as a supporting medium for immunodiffusion and immunoelectrophoresis.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
Progenitor cells from which all blood cells derive.
Insect members of the superfamily Apoidea, found almost everywhere, particularly on flowers. About 3500 species occur in North America. They differ from most WASPS in that their young are fed honey and pollen rather than animal food.
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
Glycoproteins found in a subfraction of normal mammalian plasma and urine. They stimulate the proliferation of bone marrow cells in agar cultures and the formation of colonies of granulocytes and/or macrophages. The factors include INTERLEUKIN-3; (IL-3); GRANULOCYTE COLONY-STIMULATING FACTOR; (G-CSF); MACROPHAGE COLONY-STIMULATING FACTOR; (M-CSF); and GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; (GM-CSF).
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A cytologic technique for measuring the functional capacity of tumor stem cells by assaying their activity. It is used primarily for the in vitro testing of antineoplastic agents.
The development and formation of various types of BLOOD CELLS. Hematopoiesis can take place in the BONE MARROW (medullary) or outside the bone marrow (HEMATOPOIESIS, EXTRAMEDULLARY).
Leukocytes with abundant granules in the cytoplasm. They are divided into three groups according to the staining properties of the granules: neutrophilic, eosinophilic, and basophilic. Mature granulocytes are the NEUTROPHILS; EOSINOPHILS; and BASOPHILS.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
The management and maintenance of colonies of honeybees.
Techniques used in studying bacteria.
A class in the phylum CNIDARIA, comprised mostly of corals and anemones. All members occur only as polyps; the medusa stage is completely absent.
Animal behavior associated with the nest; includes construction, effects of size and material; behavior of the adult during the nesting period and the effect of the nest on the behavior of the young.
The production of red blood cells (ERYTHROCYTES). In humans, erythrocytes are produced by the YOLK SAC in the first trimester; by the liver in the second trimester; by the BONE MARROW in the third trimester and after birth. In normal individuals, the erythrocyte count in the peripheral blood remains relatively constant implying a balance between the rate of erythrocyte production and rate of destruction.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A multilineage cell growth factor secreted by LYMPHOCYTES; EPITHELIAL CELLS; and ASTROCYTES which stimulates clonal proliferation and differentiation of various types of blood and tissue cells.
Very large BONE MARROW CELLS which release mature BLOOD PLATELETS.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
Any behavior caused by or affecting another individual, usually of the same species.
Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Social rank-order established by certain behavioral patterns.
A family of MITES in the subclass ACARI. It includes the single genus Varroa.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
The cells in the erythroid series derived from MYELOID PROGENITOR CELLS or from the bi-potential MEGAKARYOCYTE-ERYTHROID PROGENITOR CELLS which eventually give rise to mature RED BLOOD CELLS. The erythroid progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E); BFU-E differentiate into CFU-E on stimulation by ERYTHROPOIETIN, and then further differentiate into ERYTHROBLASTS when stimulated by other factors.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.
Established cell cultures that have the potential to propagate indefinitely.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. The compound stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series. M-CSF is a disulfide-bonded glycoprotein dimer with a MW of 70 kDa. It binds to a specific high affinity receptor (RECEPTOR, MACROPHAGE COLONY-STIMULATING FACTOR).
These growth factors comprise a family of hematopoietic regulators with biological specificities defined by their ability to support proliferation and differentiation of blood cells of different lineages. ERYTHROPOIETIN and the COLONY-STIMULATING FACTORS belong to this family. Some of these factors have been studied and used in the treatment of chemotherapy-induced neutropenia, myelodysplastic syndromes, and bone marrow failure syndromes.
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
Elements of limited time intervals, contributing to particular results or situations.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
The sole family in the order Sphenisciformes, comprised of 17 species of penguins in six genera. They are flightless seabirds of the Southern Hemisphere, highly adapted for marine life.
A phylum of small sessile aquatic animals living as small tufted colonies. Some appear like hydroids or corals, but their internal structure is more advanced. Most bryozoans are matlike, forming thin encrustations on rocks, shells, or kelp. (Storer & Stebbins, General Zoology, 6th ed, p443)
Signal molecules that are involved in the control of cell growth and differentiation.
An order of insects, restricted mostly to the tropics, containing at least eight families. A few species occur in temperate regions of North America.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
Any of numerous winged hymenopterous insects of social as well as solitary habits and having formidable stings.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
A hematopoietic growth factor and the ligand of the cell surface c-kit protein (PROTO-ONCOGENE PROTEINS C-KIT). It is expressed during embryogenesis and is a growth factor for a number of cell types including the MAST CELLS and the MELANOCYTES in addition to the HEMATOPOIETIC STEM CELLS.
The total process by which organisms produce offspring. (Stedman, 25th ed)
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the survival, proliferation, and differentiation of neutrophilic granulocyte precursor cells and functionally activates mature blood neutrophils. Among the family of colony-stimulating factors, G-CSF is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Colorless, endogenous or exogenous pigment precursors that may be transformed by biological mechanisms into colored compounds; used in biochemical assays and in diagnosis as indicators, especially in the form of enzyme substrates. Synonym: chromogens (not to be confused with pigment-synthesizing bacteria also called chromogens).
Diseases of Old World and New World monkeys. This term includes diseases of baboons but not of chimpanzees or gorillas (= APE DISEASES).
Proteins prepared by recombinant DNA technology.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
A cell line derived from cultured tumor cells.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.
Proteins found in any species of bacterium.
The relationships of groups of organisms as reflected by their genetic makeup.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
The etiological agent of contagious pleuropneumonia (PLEUROPNEUMONIA, CONTAGIOUS) of cattle and goats.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Infestations with arthropods of the subclass ACARI, superorder Acariformes.
Highly proliferative, self-renewing, and colony-forming stem cells which give rise to NEOPLASMS.
An encapsulated lymphatic organ through which venous blood filters.
Encrustations, formed from microbes (bacteria, algae, fungi, plankton, or protozoa) embedding in extracellular polymers, that adhere to surfaces such as teeth (DENTAL DEPOSITS); PROSTHESES AND IMPLANTS; and catheters. Biofilms are prevented from forming by treating surfaces with DENTIFRICES; DISINFECTANTS; ANTI-INFECTIVE AGENTS; and antifouling agents.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Methods for maintaining or growing CELLS in vitro.
The presence of bacteria, viruses, and fungi in food and food products. This term is not restricted to pathogenic organisms: the presence of various non-pathogenic bacteria and fungi in cheeses and wines, for example, is included in this concept.
A class in the phylum CNIDARIA which alternates between polyp and medusa forms during their life cycle. There are over 2700 species in five orders.
The functional hereditary units of BACTERIA.
Mucoproteins isolated from the kidney bean (Phaseolus vulgaris); some of them are mitogenic to lymphocytes, others agglutinate all or certain types of erythrocytes or lymphocytes. They are used mainly in the study of immune mechanisms and in cell culture.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The observable response an animal makes to any situation.
Bacterial variants, unable to form a complete cell wall, which are formed in cultures by various bacteria; granules (L bodies) appear, unite, and grow into amorphous bodies which multiply and give rise to bacterial cells morphologically indistinguishable from the parent strain.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Communication between animals involving the giving off by one individual of some chemical or physical signal, that, on being received by another, influences its behavior.
Reproductive bodies produced by fungi.
The presence of bacteria, viruses, and fungi in water. This term is not restricted to pathogenic organisms.
Techniques used in microbiology.
A genus of parasitic FUNGI in the family Nosematidae. Some species are pathogenic for invertebrates of economic importance while others are being researched for possible roles in controlling pest INSECTS. They are also pathogenic in humans.
Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.
The action of a drug in promoting or enhancing the effectiveness of another drug.
A sweet viscous liquid food, produced in the honey sacs of various bees from nectar collected from flowers. The nectar is ripened into honey by inversion of its sucrose sugar into fructose and glucose. It is somewhat acidic and has mild antiseptic properties, being sometimes used in the treatment of burns and lacerations.
DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.
Substances that reduce the growth or reproduction of BACTERIA.
A species of gram-negative, aerobic bacteria primarily found in purulent venereal discharges. It is the causative agent of GONORRHEA.
Number of individuals in a population relative to space.
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
Genotypic differences observed among individuals in a population.
A genus of gram-negative, mostly facultatively anaerobic bacteria in the family MYCOPLASMATACEAE. The cells are bounded by a PLASMA MEMBRANE and lack a true CELL WALL. Its organisms are pathogens found on the MUCOUS MEMBRANES of humans, ANIMALS, and BIRDS.
Studies determining the effectiveness or value of processes, personnel, and equipment, or the material on conducting such studies. For drugs and devices, CLINICAL TRIALS AS TOPIC; DRUG EVALUATION; and DRUG EVALUATION, PRECLINICAL are available.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Adherence of cells to surfaces or to other cells.
Blood of the fetus. Exchange of nutrients and waste between the fetal and maternal blood occurs via the PLACENTA. The cord blood is blood contained in the umbilical vessels (UMBILICAL CORD) at the time of delivery.
Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.
A pleuropneumonia of cattle and goats caused by species of MYCOPLASMA.
Mapping of the KARYOTYPE of a cell.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Immature, nucleated ERYTHROCYTES occupying the stage of ERYTHROPOIESIS that follows formation of ERYTHROID PRECURSOR CELLS and precedes formation of RETICULOCYTES. The normal series is called normoblasts. Cells called MEGALOBLASTS are a pathologic series of erythroblasts.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Any normal or abnormal coloring matter in PLANTS; ANIMALS or micro-organisms.
The relationship between two different species of organisms that are interdependent; each gains benefits from the other or a relationship between different species where both of the organisms in question benefit from the presence of the other.
A pesticide or chemical agent that kills mites and ticks. This is a large class that includes carbamates, formamides, organochlorines, organophosphates, etc, that act as antibiotics or growth regulators.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The pattern of any process, or the interrelationship of phenomena, which affects growth or change within a population.
A phylum of radially symmetrical invertebrates characterized by possession of stinging cells called nematocysts. It includes the classes ANTHOZOA; CUBOZOA; HYDROZOA, and SCYPHOZOA. Members carry CNIDARIAN VENOMS.
A subphylum of chordates intermediate between the invertebrates and the true vertebrates. It includes the Ascidians.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Social structure of a group as it relates to the relative social rank of dominance status of its members. (APA, Thesaurus of Psychological Index Terms, 8th ed.)
A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
Behavioral responses or sequences associated with eating including modes of feeding, rhythmic patterns of eating, and time intervals.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Any of several burrowing rodents of the families MURIDAE and Bathyergidae, found in eastern Europe, Africa, and Asia. They have short limbs, small eyes with permanently closed lids, and no tail. Three genera SPALAX (Muridae), Heterocephalus (Bathyergidae) and Cryptomys (Bathyergidae) are used frequently as experimental animals in biomedical research. (From Walker's Mammals of the World, 6th ed)
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
A phylum of fungi which have cross-walls or septa in the mycelium. The perfect state is characterized by the formation of a saclike cell (ascus) containing ascospores. Most pathogenic fungi with a known perfect state belong to this phylum.
Sexual activities of animals.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
A receptor for MACROPHAGE COLONY-STIMULATING FACTOR encoded by the c-fms proto-oncogene (GENES, FMS). It contains an intrinsic protein-tyrosine kinase activity. When activated the receptor undergoes autophosphorylation, phosphorylation of down-stream signaling molecules and rapid down-regulation.
Polysaccharides found in bacteria and in capsules thereof.
A genus of yeast-like mitosporic Saccharomycetales fungi characterized by producing yeast cells, mycelia, pseudomycelia, and blastophores. It is commonly part of the normal flora of the skin, mouth, intestinal tract, and vagina, but can cause a variety of infections, including CANDIDIASIS; ONYCHOMYCOSIS; vulvovaginal candidiasis (CANDIDIASIS, VULVOVAGINAL), and thrush (see CANDIDIASIS, ORAL). (From Dorland, 28th ed)
The body fluid that circulates in the vascular system (BLOOD VESSELS). Whole blood includes PLASMA and BLOOD CELLS.
A nitrosoguanidine derivative with potent mutagenic and carcinogenic properties.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Instinctual patterns of activity related to a specific area including ability of certain animals to return to a given place when displaced from it, often over great distances using navigational clues such as those used in migration (ANIMAL MIGRATION).
Methods of maintaining or growing biological materials in controlled laboratory conditions. These include the cultures of CELLS; TISSUES; organs; or embryo in vitro. Both animal and plant tissues may be cultured by a variety of methods. Cultures may derive from normal or abnormal tissues, and consist of a single cell type or mixed cell types.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The effects of ionizing and nonionizing radiation upon living organisms, organs and tissues, and their constituents, and upon physiologic processes. It includes the effect of irradiation on food, drugs, and chemicals.
Viruses infecting insects, the largest family being BACULOVIRIDAE.
Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
Order of mammals whose members are adapted for flight. It includes bats, flying foxes, and fruit bats.
The blood-making organs and tissues, principally the bone marrow and lymph nodes.
A membrane or barrier with micrometer sized pores used for separation purification processes.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
A series of steps taken in order to conduct research.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.
A unicellular budding fungus which is the principal pathogenic species causing CANDIDIASIS (moniliasis).
Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.
A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in the natural environment (soil, water, and plant surfaces) or as an opportunistic human pathogen.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Transplantation between animals of different species.
A form of interference microscopy in which variations of the refracting index in the object are converted into variations of intensity in the image. This is achieved by the action of a phase plate.
A genus of gram-positive, facultatively anaerobic, coccoid bacteria. Its organisms occur singly, in pairs, and in tetrads and characteristically divide in more than one plane to form irregular clusters. Natural populations of Staphylococcus are found on the skin and mucous membranes of warm-blooded animals. Some species are opportunistic pathogens of humans and animals.
The salinated water of OCEANS AND SEAS that provides habitat for marine organisms.
The presence of bacteria, viruses, and fungi in the soil. This term is not restricted to pathogenic organisms.
Deoxyribonucleic acid that makes up the genetic material of fungi.
Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Antibodies produced by a single clone of cells.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
The area that lies between continental North and South America and comprises the Caribbean Sea, the West Indies, and the adjacent mainland regions of southern Mexico, Central America, Colombia, and Venezuela.
Marine ridges composed of living CORALS, coral skeletons, calcareous algae, and other organisms, mixed with minerals and organic matter. They are found most commonly in tropical waters and support other animal and plant life.
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
Presence of warmth or heat or a temperature notably higher than an accustomed norm.
The presence of bacteria, viruses, and fungi in the air. This term is not restricted to pathogenic organisms.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
A myeloproliferative disorder of unknown etiology, characterized by abnormal proliferation of all hematopoietic bone marrow elements and an absolute increase in red cell mass and total blood volume, associated frequently with splenomegaly, leukocytosis, and thrombocythemia. Hematopoiesis is also reactive in extramedullary sites (liver and spleen). In time myelofibrosis occurs.
Endogenous or exogenous substances which inhibit the normal growth of human and animal cells or micro-organisms, as distinguished from those affecting plant growth (= PLANT GROWTH REGULATORS).
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Wormlike or grublike stage, following the egg in the life cycle of insects, worms, and other metamorphosing animals.
Microscopic threadlike filaments in FUNGI that are filled with a layer of protoplasm. Collectively, the hyphae make up the MYCELIUM.
An order of BIRDS including over 300 species that primarily inhabit coastal waters, beaches, and marshes. They are comprised of shorebirds, gulls, and terns.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Ribonucleic acid in bacteria having regulatory and catalytic roles as well as involvement in protein synthesis.
A functional system which includes the organisms of a natural community together with their environment. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)

Erythroid accelerating activity of rat serum in early stage of drug induced hemolysis. (1/1189)

An increase in the number of erythroblasts can be seen to some extent in the bone marrow of rats in the early stage of experimentally induced hemolytic anemia prior to any elevation in the plasma erythropoietin (Epo) level. This observation suggests that there is another erythroid stimulating factor present other than Epo. We studied the enhancing effect of serum, taken sequentially during experimentally induced hemolysis in rats, on erythroid proliferation, differentiation and maturation in vitro. Single intraperitoneal injection of 60 mg/kg of acetylphenylhydrazine (APH) induced self-limited hemolytic anemia in rats, in which the hematocrit dropped rapidly with a nadir at day 4 after APH injection, followed by a gradual increase with return to normal level by day 8. Serum obtained consecutively every day after APH injection from day 1 to day 7 was applied to an in vitro culturing system of erythroid progenitors. Addition of day 1 serum, in which an elevation of Epo level had not occurred, to a conventional methyl-cellulose culture of rat bone marrow mononuclear cells (BM-MNCs) resulted in a significant increase in the number of colonies derived from colony forming unit erythroid, but not in burst forming unit erythroid. This erythropoietic activity of the serum was particularly evident in the presence of Epo. In the liquid culture of BM-MNCs, day 1 serum also showed some enhancing effect on erythroblast formation. We were able to see significant differences in these erythroid enhancing activities induced by serum drawn on day 1 in comparison to the serum drawn on subsequent days. These results suggest that an unknown erythroid enhancing factor besides Epo stimulates erythropoiesis in the early stage of hemolytic anemia or sudden hypoxia before there is a measurable rise in the serum Epo level. We propose that this factor be termed erythroid accelerating factor (EAF).  (+info)

Involvement of the retinoblastoma protein in monocytic and neutrophilic lineage commitment of human bone marrow progenitor cells. (2/1189)

The retinoblastoma gene product (pRb) is involved in both cell cycle regulation and cell differentiation. pRb may have dual functions during cell differentiation: partly by promoting a cell cycle brake at G(1) and also by interacting with tissue-specific transcription factors. We recently showed that pRb mediates differentiation of leukemic cell lines involving mechanisms other than the induction of G(1) arrest. In the present study, we investigated the role of pRb in differentiation of human bone marrow progenitor cells. Human bone marrow cells were cultured in a colony-forming unit-granulocyte-macrophage (CFU-GM) assay. The addition of antisense RB oligonucleotides (alpha-RB), but not the addition of sense orientated oligonucleotides (SO) or scrambled oligonucleotides (SCR), reduced the number of colonies staining for nonspecific esterase without affecting the clonogenic growth. Monocytic differentiation of CD34(+) cells supported by FLT3-ligand and interleukin-3 (IL-3) was correlated to high levels of hypophosphorylated pRb, whereas neutrophilic differentiation, supported by granulocyte colony-stimulating factor (G-CSF) and stem cell factor (SCF), was correlated to low levels. The addition of alpha-RB to liquid cultures of CD34(+) cells, supported with FLT3-ligand and IL-3, inhibited monocytic differentiation. This was judged by morphology, the expression of CD14, and staining for esterase. Moreover, the inhibition of monocytic differentiation of CD34(+) cells mediated by alpha-RB, which is capable of reducing pRb expression, was counterbalanced by an enhanced neutrophilic differentiation response, as judged by morphology and the expression of lactoferrin. CD34(+) cells incubated with oligo buffer, alpha-RB, SO, or SCR showed similar growth rates. Taken together, these data suggest that pRb plays a critical role in the monocytic and neutrophilic lineage commitment of human bone marrow progenitors, probably by mechanisms that are not strictly related to control of cell cycle progression.  (+info)

Direct evidence for multiple self-renewal divisions of human in vivo repopulating hematopoietic cells in short-term culture. (3/1189)

Recently, culture conditions that stimulate the proliferation of primitive hematopoietic cells defined by various phenotypic and functional endpoints in vitro have been identified. However, evidence that they support a high probability of self-renewal leading to a large net expansion in vitro of transplantable cells with lympho-myeloid repopulating ability has been more difficult to obtain. The present study was designed to investigate whether the low overall expansion of human repopulating hematopoietic cells seen in vitro reflects a selective unresponsiveness of these rare cells to the growth factors currently used to stimulate them or, alternatively, whether they do proliferate in vitro but lose engrafting potential. For this, we used a high-resolution procedure for tracking and reisolating cells as a function of their proliferation history based on the loss of cellular fluorescence after staining with (5- and 6-) carboxyfluorescein diacetate succinimidyl ester. The results show that the vast majority of long-term culture-initiating cells and in vivo lympho-myeloid competitive repopulating units present in 5-day suspension cultures initiated with CD34(+) human cord blood and fetal liver cells are the progeny of cells that have divided at least once in response to stimulation by interleukin-3, interleukin-6, granulocyte colony-stimulating factor, Steel factor, and Flt3-ligand. Thus, most human repopulating cells from these two sources are stimulated to undergo multiple divisions under currently used short-term suspension culture conditions and a proportion of these retain engraftment potential.  (+info)

Isolation of MYADM, a novel hematopoietic-associated marker gene expressed in multipotent progenitor cells and up-regulated during myeloid differentiation. (4/1189)

A large number of hematopoietic cytokines and their receptors as well as transcription factors have been shown to be involved in maturation of blood cells. However, many of the genes important for the differentiation of multipotent stem cells to specific cellular lineages are still unknown. To identify novel genes involved in lineage selection of myeloid cells, we have applied differential display analysis during commitment toward granulocytes and macrophages of an IL-3-dependent multipotent progenitor cell line, FDCP-mix. One regulated cDNA represented a novel gene with restricted expression pattern within the hematopoietic system and was strongly up-regulated when FDCP-mix cells differentiated in GM-CSF, G-CSF, and M-CSF. The expression appears to be differentiation stage-specific in myeloid cells and is absent in B and T lymphocytes. Thus we found expression in normal mouse bone marrow enriched for stem cells and multipotent progenitors (c-kit+Sca-1+Lin- cells). When these cells were induced to differentiate toward myeloid cells, MYADM was up-regulated. In contrast, during conditions known to favor the development of B cell progenitors, the gene was down-regulated. The gene, termed MYADM for myeloid-associated differentiation marker gene, shows 100% identity to expressed sequence tags from early mouse embryonic development as well as from the mouse lung and from activated mouse macrophages. The predicted 32-kDa MYADM protein contains multiple hydrophobic putative transmembrane segments and has several potential consensus sites for phosphorylation. In view of its expression pattern, MYADM could serve as a new marker gene for hematopoietic differentiation. Although the function is unknown, antisense oligonucleotides were able to inhibit colony formation of c-kit+ Lin- bone marrow cells, suggesting an important role for MYADM in myeloid differentiation.  (+info)

Stimulation of granulocytic colony formation in agar diffusion chambers implanted in cyclophosphamide pretreated mice. (5/1189)

The growth of mouse bone marrow colonies in agar diffusion chambers (ADCs) was evaluated using host mice injected with saline or with cyclophosphamide (CY) before chamber insertion. The mice pretreated with cyclophosphamide proved more effective hosts than control (saline pretreated) mice, indicating that cyclophosphamide causes the elaboration of a stimulating factor acting on colony precursor cells. Assays of the factor for colony stimulating activity against mouse bone marrow cells in agar culture in vitro suggest that potentiation may be due to a slight temporary increase in the level of colony stimulating factor (CSF) in the chamber environment, although a parallel increase was not detected in the serum. Stem cell recovery from the ADCs, measured by spleen colony formation, suggests that the stimulus may act by increasing differentiation at the level of the pluripotential stem cell.  (+info)

Clonal growth of hamster free alveolar cells in soft agar. (6/1189)

Free alveolar cells obtained from healthy unstimulated hamsters were tested for their ability to form colonies in soft agar. Every bronchial washing so far tested contained colon-forming cells. The average plating efficiency was 8.1% (2.4-18.3%). Alveolar colony-forming cells were characterized by having a long initial lag period (4-8 days) and only mononuclear phagocytes were found in the colony. Medium conditioned by baby hamster kidney cells or other cells was required for the initiation and maintenance of their growth. Alveolar cells from normal mice and rats also formed colonies under appropriate culture conditions.  (+info)

Colony-stimulating factor (CSF) in the uterus of the pregnant mouse. (7/1189)

During the growth of the pregnant uterus of inbred Balb/c mice uterine colony-stimulating factor (CSF) content increased 800-fold. This corresponded to a 75-fold increase in CSF concentration. The size of the increase was the same in the uteri of inbred Balb/c mice and the uteri of F1 hybrid C57Bl/Balb/c mice mated with F1 males. It was about four times greater in these uteri than it was in the uteri of randomly mated TO mice. After unilateral Fallopian tubal ligation of TO mice the concentration of CSF was as great in the non-gravid uterine horns as it was in the gravid uterine horns. Physicochemical characterization of CSF from extracts of pregnant uterus showed that it differed from that found in foetal extracts and that found in the circulation. Its function in the pregnant uterus is discussed.  (+info)

Growth stimulation of human bone marrow cells in agar culture by vascular cells. (8/1189)

Human vascular cells are capable of stimulating granulopoiesis in agar culture of human bone marrow cells. This effect was obtained by including vein fragments in the culture or by using endothelial cells separated from the vein of human umbilical cords as feeder cells. Furthermore, the stimulatory capacity of conditioned medium obtained from cord veins was found to be highly active in comparison to that obtained from peripheral leukocytes. Endothelial cells within the bond marrow cavity are suggested as a local source of factors regulating granulopoiesis in humans in addition to the monocyte.  (+info)

1. Colony-stimulating activity appeared in the perfusate of the isolated rat liver during perfusions with either whole rat blood, rat plasma or an artificial perfusate of Eagles medium and albumin.. 2. Dialysable inhibitors of colony formation were also released during perfusions.. 3. Colony-stimulating activity in artificial perfusate could be enhanced by the addition of rat plasma in vitro. Concentrations of cycloheximide that inhibited albumin synthesis by the liver did not inhibit the release of colony-stimulating activity. ...
The effects of media conditioned by leukemic cells from 11 acute myeloblastic leukemia patients on the growth of autologous blast progenitors were studied. First, it was shown that T-cell-depleted leukemic cells from some patients release high levels of colony-stimulating activity into the culture medium, whereas following further depletion of phagocytic cells, the levels of colony-stimulating activity become undetectable. Second, media conditioned by purified blast cell fraction depleted of both T-cells and phagocytic cells potentiated autologous blast progenitor growth both in methylcellulose and suspension cultures stimulated by optimal concentration of media conditioned by human bladder carcinoma line 5637. Third, media conditioned by these purified blast cells generally did not contain measurable colony-stimulating activity or interleukin 1, whereas substantial levels of granulocyte colony-stimulating factor, granulocyte-macrophage colony-stimulating factor, and interleukin 1 were observed ...
TY - JOUR. T1 - Recombinant human macrophage colony-stimulating factor in nonhuman primates. T2 - Selective expansion of a CD16+ monocyte subset with phenotypic similarity to primate natural killer cells. AU - Munn, David H.. AU - Bree, Andrea G.. AU - Beall, Arthur C.. AU - Kaviani, Michelle D.. AU - Sabio, Hernan. AU - Schaub, Robert G.. AU - Alpaugh, R. Katherine. AU - Weiner, Louis M.. AU - Goldman, Samuel J.. PY - 1996/8/15. Y1 - 1996/8/15. N2 - The CD16 receptor (FcγR-III) is found on many tissue macrophages (Mφs), but its expression on circulating monocytes is restricted to a small, phenotypically distinct subset. The number of these CD16+ monocytes may be markedly increased in response to sepsis, human immunodeficiency virus infection, or metastatic malignancy. We have recently shown that the CD16+ monocyte population is selectively expanded by administration of recombinant human macrophage colony-stimulating factor (rhM-CSF). In the current study, we used the highly rhM-CSF-responsive ...
Find information on Sargramostim (Leukine, rHu GM-CSF - recombinant human granulocyte/macrophage colony-stimulating factor) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Davis Drug Guide PDF.
TY - JOUR. T1 - Effects of recombinant human granulocyte-macrophage colony-stimulating factor on myelosuppression induced by multiple cycles of high-dose chemotherapy in patients with advanced breast cancer. AU - Hoekman, Klaas. AU - Wagstaff, John. AU - Van Groeningen, Cees J.. AU - Vermorken, Jan B.. AU - Boven, Epie. AU - Pinedo, Herbert M.. PY - 1991/11/6. Y1 - 1991/11/6. N2 - In this study, 18 patients with advanced breast cancer were treated with multiple cycles of doxorubicin (75 or 90 mg/m2) plus cyclophosphamide (750 or 1000 mg/m2) every 21 days. Granulocyte-macrophage colony-stimulating factor (GM-CSF) (250 μg/m2 per day) was administered by continuous infusion during 10 days (days 2-12), starting in the first or second cycle of chemotherapy. Sixteen (89%) of 18 patients (95% confidence interval, 65%-99%) achieved an objective remission, five (28%) of which were complete. The median duration of response was 7 months. When GM-CSF was used for the first time, it had an effect on the ...
TY - JOUR. T1 - Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. AU - Dranoff, Glenn. AU - Jaffee, Elizabeth. AU - Lazenby, Audrey. AU - Golumbek, Paul. AU - Levitsky, Hyam. AU - Brose, Katja. AU - Jackson, Valerie. AU - Hamada, Hirofumi. AU - Pardoll, Drew. AU - Mulligan, Richard C.. PY - 1993/4/15. Y1 - 1993/4/15. N2 - To compare the ability of different cytokines and other molecules to enhance the immunogenicity of tumor cells, we generated 10 retroviruses encoding potential immunomodulators and studied the vaccination properties of murine tumor cells transduced by the viruses. Using a B16 melanoma model, in which irradiated tumor cells alone do not stimulate significant anti-tumor immunity, we found that irradiated tumor cells expressing murine granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulated potent, long-lasting, and specific anti-tumor ...
TY - JOUR. T1 - Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice. AU - Michelini, Zuleika. AU - Negri, Donatella. AU - Biava, Mirella. AU - Baroncelli, Silvia. AU - Spada, Massimo. AU - Leone, Pasqualina. AU - Bona, Roberta. AU - Blasi, Maria. AU - Nègre, Didier. AU - Klotman, Mary E.. AU - Cara, Andrea. PY - 2014/12/1. Y1 - 2014/12/1. N2 - As a prelude to immunization studies in nonhuman primates, we compared in mice the immunogenicity of a simian immunodeficiency virus (SIV)-based integrase (IN)-defective lentiviral vector (IDLV) encoding the model antigen-enhanced green fluorescence protein (eGFP) in the presence or absence of the murine granulocyte-macrophage colony-stimulating factor (mGM-CSF) expressed from an internal ribosomal entry site (IRES) sequence. BALB/c mice were immunized once intramuscularly with IDLV expressing eGFP alone or ...
Purchase Recombinant Human Granulocyte-macrophage colony-stimulating factor(CSF2). It is produced in E.coli. High purity. Good price.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is active in enhancing the production of mature myeloid cells in vitro and several phase 1/11 clinical trials have suggested that its administration may accelerate neutrophil recovery after autologous bone marrow transplantation (ABMT). We have conducted a multicentre randomized double-blind placebo controlled trial in patients with poor prognosis malignant lymphoma receiving an identical high-dose combination chemotherapy regimen with ABMT. 61 patients were entered and 29 in each arm of the trial were evaluated. Treatment with GM-CSF did not affect the period of severe neutropenia (absolute neutrophil count (ANC) of , 0.1 x 10(9)/l) but accelerated recovery to an ANC of 0.5 x 10(9)/l (median 14 d v 20 d in controls, P = 0.001).There was no significant difference in platelet recovery between the groups (GM-CSF group platelet dependent for 25 d v control 19 d, P = NS). The number of positive blood cultures was similar in both groups ...
Effectiveness of recombinant human granulocyte macrophage colony-stimulating issue for treating deep second-degree burns: a scientific evaluation and meta-analysis. Its unsure whether or not remedy by recombinant human granulocyte macrophage colony-stimulating issue (rhGM-CSF) can promote therapeutic of deep second-degree burns. This meta-analysis aimed to systematically evaluation and assess randomised managed trials (RCTs) that investigated the efficacy and security of rhGM-CSF for treating deep second-degree burns. This meta-analysis conformed […]. ...
This randomized clinical trial examines the effect of recombinant human granulocyte colony-stimulating factor on peripheral blood leukocyte and lymphocyte cell
TY - JOUR. T1 - Effects of Granulocyte-Macrophage Colony-Stimulating Factor on Neuronal Senescence in Ultraviolet Irradiated Skin. AU - Moon, Kyung Chul. AU - Lee, Hyun Su. AU - Son, Seung Tae. AU - Lee, Jae Sun. AU - Dhong, Eun-Sang. AU - Jeong, Seong-Ho. AU - Han, Seung-Kyu. PY - 2019/5/1. Y1 - 2019/5/1. N2 - Ultraviolet (UV) irradiation affects neuronal structures of the skin and accelerates skin aging. Cytokine cascades in keratinocytes after UV irradiation may result in a paracrine inhibitory effect on nerve cells. The purpose of the present study was to determine the direct effect of cytokines induced by UV radiation on nerve cells in terms of neuronal senescence. Our group performed a preliminary study to determine cytokines induced in UV-irradiated keratinocytes. Among 40 cytokines studied, granulocyte-macrophage colony-stimulating factor (GM-CSF) was increased 4-fold in inflammation antibody array. The GM-CSF was added to cultured human neuroblastoma cells. To evaluate the effect of ...
Abstract. Recombinant human granulocyte colony-stimulating factor (rhG-CSF) enhanced superoxide release and membrane depolarization in parallel in human granulo
TY - JOUR. T1 - Effect of ovine granulocyte-macrophage colony-stimulating factor on bovine in vitro embryo development and blastocyst interferon-s secretion. AU - Hickman, CF. AU - Ainslie, A. AU - Ealy, AD. AU - Ashworth, CJ. AU - Rooke, JA. N1 - 621723. PY - 2011. Y1 - 2011. KW - Blastocyst. KW - Bovine. KW - Development. KW - Effect. KW - Embryo. KW - Factor. KW - In Vitro. KW - Ovine. KW - Secretion. M3 - Article. VL - 46. SP - 608. EP - 615. JO - Reproduction in Domestic Animals. JF - Reproduction in Domestic Animals. SN - 0936-6768. ER - ...
Objective: The aim of the study is to investigate the effectiveness of the controlled slow-release granulocyte-monocyte colony-stimulating factor (GM-CSF) system in burn wound healing. ...
Cells and reagents. The cell lines used in this study were obtained from the American Type Culture Collection or the DSMZ. The MM.1S and MM.1R cell lines were a kind gift of Dr. Steven Rosen (Northwestern University, Chicago, IL). Cells were maintained in RPMI 1640 (Life Technologies, Inc.) supplemented with 10% fetal bovine serum. CD70 expression was quantified using the murine anti-CD70 antibody clone 1F6 and a Dako QiFi KiT flow cytometric indirect immunofluorescence assay (Dako). Monocyte-derived macrophages were prepared by culturing adherent leukocytes in 500 units/mL recombinant human granulocyte macrophage colony-stimulating factor (PeproTech) for 10 to 15 days as previously described (25). Cells recovered from these cultures were CD3/CD19 negative and expressed CD14, CD11b, CD16, CD32, and CD64 as determined by flow cytometry. Macrophage and T- and B-cell-specific fluorochrome-conjugated antibodies were purchased from BD Biosciences. CD138- and CD70-specific phycoerythrin-conjugated ...
To evaluate the safety of repeated courses of sargramostim ( recombinant granulocyte-macrophage colony-stimulating factor; GM-CSF ) administered subcutaneously to patients with HIV infection and leukopenia. To determine if administration of GM-CSF will prevent some or all of the hematologic toxicity associated with zidovudine ( AZT ) treatment in patients with pre-existing leukopenia. To assess any clinical and/or virologic benefits from administering alternating weeks of GM-CSF and AZT to patients with symptomatic HIV infection who have a history of cytologically confirmed Pneumocystis carinii pneumonia ( PCP ) or a circulating absolute CD4 lymphocyte count less than 200 cells/mm3 ...
Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor is produced by our Yeast expression system and the target gene encoding Ala18-Glu144 is expressed.
The gene IL-3 encodes interleukin 3, a hematopoietic colony-stimulating factor (CSF) that is capable of supporting the proliferation of a broad range of hematopoietic cell types. By using somatic cell hybrids and in situ chromosomal hybridization, we localized this gene to human chromosome 5 at bands q23-31, a chromosomal region that is frequently deleted [del(5q)] in patients with myeloid disorders. By in situ hybridization, IL-3 was found to be deleted in the 5q-chromosome of one patient with refractory anemia who had a del(5)(q15q33.3), of three patients with refractory anemia (two patients) or acute nonlymphocytic leukemia (ANLL) de novo who had a similar distal breakpoint [del(5)(q13q33.3)], and of a fifth patient, with therapy-related ANLL, who had a similar distal breakpoint in band q33 [del(5)(q14q33.3)]. Southern blot analysis of somatic cell hybrids retaining the normal or the deleted chromosome 5 from two patients with the refractory anemia 5q- syndrome indicated that IL-3 sequences were
TY - JOUR. T1 - The Effects of Oxidizing Species Derived from Molecular Oxygen on the Proliferation In Vitro of Human Granulocyte‐Macrophage Progenitor Cells. AU - BROXMEYER, HAL E.. AU - COOPER, SCOTT. AU - GABIC, THEODORE. PY - 1989/5. Y1 - 1989/5. N2 - In order to better understand the enhancing effects of lowered oxygen (O2) tension on the growth in vitro of granulocyte-macrophage progenitor cells (CFU-GM), the effects of oxidizing species derived from molecular O2 were assessed on CFU-GM. Low density or nonadherent low density normal human bone marrow cells were plated at ambient (20%) or lowered (5%) O2 tension in the presence of a source of colony stimulating factors, and in the absence or presence of superoxide dismutase, catalase, glucose oxidase or horseradish peroxidase, alone or in various combinations. Enhanced colony and cluster formation of CFU-GM was noted when low density cells were grown at 5% O2, or when cells were grown at 20% O2 in the presence of superoxide dismutase or ...
The magnitude of blindness and low vision in this oil what is cialis rich Ozoro community in Delta State is high and majority are avoidable causes of blindness. In contrast, temperate and tropical stoneflies exhibited similar acclimation responses. Subjects in Group A were equally divided into A1 (500 mg single bolus injection) and A2 (500 mg split dose).. Escalated MVAC with or without recombinant human granulocyte-macrophage colony-stimulating factor for the initial treatment of advanced malignant urothelial tumors: results of a randomized trial. Central to the system is an infuse-withdraw micropump component that, unlike previous micropump-based systems, has fully integrated drug and fluid storage compartments. Upon electrophoresis on denaturating gels, ribosomal RNA fraction of H.. We conducted a randomized, blinded crossover study of aldosterone vs vehicle and compared the effects of a low-sodium versus a high-sodium diet. Performance prediction of a synchronization link for distributed ...
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To assess the safety and efficacy of subcutaneous sargramostim ( granulocyte-macrophage colony-stimulating factor; GM-CSF ) in increasing and maintaining the granulocyte count in HIV-infected children who have developed granulocytopenia as a result of continuous intravenous ( CIV ) zidovudine ( AZT ). To assess the short-term and long-term effects of concomitant GM-CSF on other hematologic parameters. To assess the potential therapeutic benefit of concomitant GM-CSF and AZT on the natural history of HIV infection and associated infectious complications ...
Murine sarcoma MC12 cells were transfected with the gene coding for murine granulocyte-macrophage colony-stimulating factor (GM-CSF). Tumorigenicity of a variety of cell clones with different expression of the inserted gene was assessed. All of the genetically manipulated MC12 cell clones examined were found to be less tumorigenic than the parental MC12 cell population. No correlation was observed between the production of GM-CSF by the clones and their tumorigenicity. It has been found that irradiation of the GM-CSF-producing cells with the dose of 150 Gy did not significantly inhibit the GM-CSF production during the period of 5 days after irradiation. These findings provided us with the rationale for using the irradiated GM-CSF-producing MC12 sarcoma vaccine for therapy. It has further been found than immunosensitivity of the genetically manipulated, GM-CSF-producing tumour targets to the IL-2-activated killer (LAK) cell-mediated cytolysis was significantly increased, as compared to the ...
Human colony-stimulating factor 1 receptor (hCSF-1R) is unique among the hematopoietic receptors because it is activated by two distinct cytokines, CSF-1 and interleukin-34 (IL-34). Despite ever-growing insights into the central role of hCSF-1R signaling in innate and adaptive immunity, inflammatory diseases, and cancer, the structural basis of the functional dichotomy of hCSF-1R has remained elusive. Here, we report crystal structures of ternary complexes between hCSF-1 and hCSF-1R, including their complete extracellular assembly, and propose a mechanism for the cooperative human CSF-1:CSF-1R complex that relies on the adoption by dimeric hCSF-1 of an active conformational state and homotypic receptor interactions. Furthermore, we trace the cytokine-binding duality of hCSF-1R to a limited set of conserved interactions mediated by functionally equivalent residues on CSF-1 and IL-34 that play into the geometric requirements of hCSF-1R activation, and map the possible mechanistic consequences of ...
In this study, hematopoietic cells from mice pretreated with CVE and exposed to acute cold/restraint stress were stimulated in the presence of growth factors to form colonies, thus providing accurate information about the modulation of the green algae of the stress-induced changes in the hematopoietic response. Our results demonstrated that exposure to acute stress affected hematopoiesis. Mice exposed for a 2.5-hour time period of cold and restraint presented diminished clonal capacity for CFU-GM content per femur, which was decreased by as much as 50% compared with that in control mice, in spite of the significant increase in serum colony-stimulating activity (CSA). Treatment with 50 mg/kg CVE for 5 days, previously to the stress regimen, attenuates the effects of the stress, since comparable levels of myeloid progenitors were found in the bone marrow of both CVE/stress and control mice. Moreover, the sera from stressed mice pretreated with CVE further increased the CFU-GM formation. On the ...
Buy our Recombinant human GM-CSF protein. Ab9668 is an active full length protein produced in Escherichia coli and has been validated in FuncS, SDS-PAGE. Abcam…
Savara Pharmaceuticals (previously Serendex Pharmaceuticals) is developing an inhaled formulation of molgramostim, a recombinant human granulocyte macrophage
TY - JOUR. T1 - Proliferation and maturation effects of in-vivo granulocyte-macrophage colony stimulating factor in acute non-lymphocyte luekaemia. AU - Damiani, D.. AU - Michieli, M.. AU - Revignas, M. G.. AU - Russo, D.. AU - Fanin, R.. AU - Michelutti, A.. AU - Mallardi, F.. AU - Baccarani, M.. PY - 1992. Y1 - 1992. UR - http://www.scopus.com/inward/record.url?scp=0026574360&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0026574360&partnerID=8YFLogxK. M3 - Article. C2 - 1398278. AN - SCOPUS:0026574360. VL - 77. SP - 25. EP - 29. JO - Haematologica. JF - Haematologica. SN - 0390-6078. IS - 1. ER - ...
GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development
TY - JOUR. T1 - Protective effect of recombinant murine granulocyte-macrophage colony-stimulating factor against Pseudomonas aeruginosa infection in leukocytopenic mice. AU - Tanaka, T.. AU - Okamura, S.. AU - Okada, K.. AU - Suga, A.. AU - Shimono, N.. AU - Ohhara, N.. AU - Hirota, Y.. AU - Sawae, Y.. AU - Niho, Y.. N1 - Copyright: Copyright 2004 Elsevier B.V., All rights reserved.. PY - 1989. Y1 - 1989. N2 - The effects of recombinant murine granulocyte-macrophage colony-stimulating factor (rmGM-CSF) against Pseudomonas aeruginosa infection in ICR mice were investigated. Mice were treated with cyclophosphamide (CPA) and were then injected intraperitoneally with rmGM-CSF three times daily, beginning on the day after CPA treatment, for 7 days. The number of peripheral blood leukocytes in both CPA- and rmGM-CSF-treated mice and control CPA-treated mice reached a nadir on day 4, when P. aeruginosa was injected intraperitoneally. The administration of rmGM-CSF significantly increased the proportion ...
TY - JOUR. T1 - Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors. AU - Hisakawa, Hiroaki. AU - Sugiyama, Daisuke. AU - Nishijima, Ichiko. AU - Xu, Ming Jiang. AU - Wu, Hong. AU - Nakao, Kazuki. AU - Watanabe, Sumiko. AU - Katsuki, Motoya. AU - Asano, Shigetaka. AU - Aral, Ken Ichi. AU - Nakahata, Tatsutoshi. AU - Tsuji, Kohichiro. PY - 2001/12/15. Y1 - 2001/12/15. N2 - Although erythropoietin (EPO) and its receptor (EPOR) are crucial for the proliferation, survival, and terminal differentiation of erythroid progenitors, it remains to be elucidated whether EPOR-unique signaling is required for erythropoiesis. To address this issue, human granulocyte-macrophage colony-stimulating factor (hGM-CSF) receptor (hGMR)-transgenic mice and heterozygous EPOR mutant mice were crossed by in vitro fertilization. In methylcellulose clonal culture of fetal liver (FL) ...
Study Objective: To determine whether recombinant human granulocyte colony-stimulating factor (G-CSF) is effective in increasing neutrophil counts in patients with hairy cell leukemia and neutropenia.. Design: Open label, phase I/II study of G-CSF, given by daily subcutaneous injection for up to 7 weeks.. Setting: Outpatient oncology clinic of a university medical center.. Patients: A consecutive sample of four patients with hairy cell leukemia complicated by severe neutropenia. Three patients completed the study; one patient was removed after 2 weeks of therapy.. Interventions: Granulocyte colony-stimulating factor was given by daily subcutaneous injection. Each patient began therapy with 1 µg/kg body weight ·d; after 1 week the dose was increased to 3 µg/kg ·d, and 1 week later to 6 µg/ kg ·d. Therapy was continued for 5 to 6 weeks. Patients were taught self-injection, and administered treatment at home.. Measurements and main results: In three patients, an increase in absolute ...
TY - JOUR. T1 - Macrophage colony-stimulating factor in cooperation with transforming growth factor-β1 induces the differentiation of CD34+ hematopoietic progenitor cells into Langerhans cells under serum-free conditions without granulocyte-macrophage colony-stimulating factor. AU - Mollah, Zia U.A.. AU - Aiba, Setsuya. AU - Nakagawa, Satoshi. AU - Hara, Masahiro. AU - Manome, Hideaki. AU - Mizuashi, Masato. AU - Ootani, Tomoyuki. AU - Yoshino, Yumiko. AU - Tagami, Hachiro. PY - 2003/2/1. Y1 - 2003/2/1. N2 - Macrophage colony-stimulating factor has not been considered as a factor responsible for dendritic cell or Langerhans cell development from hematopoietic progenitor cells. In this study, we examined whether macrophage colony-stimulating factor could be used instead of granulocyte-macrophage colony-stimulating factor for the in vitro development of Langerhans cells from hematopoietic progenitor cells. We replaced granulocyte-macrophage colony-stimulating factor with macrophage ...
We show that cytotoxic T lymphocytes (CTLs) infiltrating a kidney tumor recognize a peptide encoded by an alternative open reading frame (ORF) of the macrophage colony-stimulating factor (M-CSF) gene. Remarkably, this alternative ORF, which is translated in many tumors concurrently with the major ORF, is also translated in some tissues that do not produce M-CSF, such as liver and kidney. Such a dissociation of the translation of two overlapping ORFs from the same gene is unexpected. The antigenic peptide encoded by the alternative ORF is presented by human histocompatibility leukocyte antigen (HLA)-B*3501 and has a length of 14 residues. Peptide elution indicated that tumor cells naturally present this 14 mer, which is the longest peptide known to be recognized by CTLs. Binding studies of peptide analogues suggest that it binds by its two extremities and bulges out of the HLA groove to compensate for its length.
Interleukin-3; Burst-Promoting Factor, Erythrocyte; Colony-Stimulating Factor, Mast-Cell; Colony-Stimulating Factor, Multipotential; Colony-Stimulating Factor 2 Alpha; Erythrocyte Burst-Promoting Factor; Multipotential Colony-Stimulating Factor; P-Cell Stimulating Factor; IL-3; Mast-Cell Colony-Stimulating Factor. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.
TY - JOUR. T1 - Pilot study of granulocyte-macrophage colony-stimulating factor and interleukin-2 as immune adjuvants for a melanoma peptide vaccine. AU - Block, Matthew S.. AU - Suman, Vera J.. AU - Nevala, Wendy K.. AU - Kottschade, Lisa A.. AU - Creagan, Edward T.. AU - Kaur, Judith S.. AU - Quevedo, Jorge Fernando. AU - McWilliams, Robert R.. AU - Markovic, Svetomir N.. PY - 2011/10/1. Y1 - 2011/10/1. N2 - Thus far, peptide vaccines used to stimulate tumor-specific immune responses in patients with melanoma have been largely unsuccessful. Granulocyte-macrophage colony-stimulating factor and interleukin-2 are immune-potentiating cytokines that have improved vaccine responses in preclinical models. We hypothesized that higher doses of granulocyte-macrophage colony-stimulating factor and addition of low-dose interleukin-2 might augment responses to vaccine antigens. Patients with resected stage II, III, or IV melanoma were treated with vaccines containing three melanoma-associated peptides ...
Fingerprint Dive into the research topics of Influence of filgrastim (granulocyte colony-stimulating factor) on human immunodeficiency virus type 1 RNA in patients with cytomegalovirus retinitis. Together they form a unique fingerprint. ...
Recombinant human granulocyte-macrophage colony stimulating factor (sargramostim) as an alternative therapy for fistulizing Crohns disease.
The mortality rate at eight weeks was similar in the lenograstim and placebo groups (23 and 27 percent, respectively; P = 0.60), as was the incidence of severe infections. The median duration of neutropenia (absolute neutrophil count , or = 1000 per cubic millimeter) was shorter in the lenograstim group (21 days, as compared with 27 days in the placebo group; P , 0.001). Eight percent of the patients in both groups had regrowth of AML cells. The rate of complete remission was significantly higher in the lenograstim group (70 percent, as compared with 47 percent in the placebo group; P = 0.002). Overall survival, however, was similar in the two groups (P = 0.76). Conclusions: ...
Definition of Colony-stimulating factors in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is Colony-stimulating factors? Meaning of Colony-stimulating factors as a legal term. What does Colony-stimulating factors mean in law?
Product Name: Mouse mAb anti- human Granulocyte Macrophage Colony Stimulating Factor (GM-CSF), Tracer (HRP Labeled), Clone 429Collection: AntibodySub Category:
Hemopoietic growth factors regulate the differentiation and proliferation of particular progenitor cells. Made available through recombinant DNA technology, they hold tremendous potential for medical uses when a persons natural ability to form blood cells is diminished or defective. Recombinant erythropoietin (EPO) is very effective in treating the diminished red blood cell production that accompanies end-stage kidney disease. Erythropoietin is a sialoglycoprotein hormone produced by peritubular cells of kidney Granulocyte-macrophage colony-stimulating factor and granulocyte CSF are given to stimulate white blood cell formation in cancer patients who are receiving chemotherapy, which tends to kill their red bone marrow cells as well as the cancer cells. Thrombopoietin shows great promise for preventing platelet depletion during chemotherapy. CSFs and thrombopoietin also improve the outcome of patients who receive bone marrow transplants. Colony-stimulating ...
Looking for colony-stimulating factor? Find out information about colony-stimulating factor. A group of lymphocytes that induce the maturation and proliferation of leukocyte, macrophage, and monocyte lines present in bone marrow Explanation of colony-stimulating factor
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is often used to treat leucopenia. Other haematopoietins may increase the number of circulating leucocytes with higher efficiency, but GM-CSF
Increased numbers of eosinophils and mast cells in the bronchial mucosa are characteristic features in subjects with aspirin-sensitive asthma. Interleukin-5 (IL-5) and granulocyte-macrophage colony-stimulating factor (GM-CSF) are involved in the activation, maturation, and perpetuation of survival o …
Transgenic expression of granulocyte-macrophage colony-stimulating factor induces the differentiation and activation of a novel dendritic cell population in the lung Academic Article ...
An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages ...
cost. 2 Prophylactic use of recombinant human granulocyte colony-stimulating factors (G-CSFs), such as filgrastim or pegfilgrastim, can significantly reduce FN risk and FN-related costs. 3 - 5 The risk of developing FN depends on patient and disease. ...
TY - JOUR. T1 - Inhaled granulocyte-macrophage colony stimulating factor for first pulmonary recurrence of osteosarcoma. T2 - Effects on disease-free survival and immunomodulation. A report from the Childrens Oncology Group. AU - Arndt, Carola A.S.. AU - Koshkina, Nadya V.. AU - Inwards, Carrie Y.. AU - Hawkins, Douglas S.. AU - Krailo, Mark D.. AU - Villaluna, Doojduen. AU - Anderson, Peter M.. AU - Goorin, Allen M.. AU - Blakely, Martin L.. AU - Bernstein, Mark. AU - Bell, Sharon A.. AU - Ray, Kaylee. AU - Grendahl, Darryl C.. AU - Marina, Neyssa. AU - Kleinerman, Eugenie S.. PY - 2010/8/1. Y1 - 2010/8/1. N2 - Purpose: Osteosarcoma most commonly recurs in the lung. Based on preliminary data on the antitumor effects of granulocyte-macrophage colony stimulating factor (GM-CSF) in animal models, and promising phase I trials, we embarked on a feasibility study of inhaled GM-CSF in patients with first isolated pulmonary recurrence of osteosarcoma. Experimental Design: Forty-three eligible patients ...
Identification of the soluble granulocyte-macrophage colony stimulating factor receptor protein in vivo and development of a soluable model of the high affinity cell surface receptor for granulocyte-macrophage colony stimulating ...
M-CSF, also called CSF-1, is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells
T-helper cells producing interleukin (IL)-17A and IL-17F cytokines (Th17 cells) are considered the source of autoimmunity in rheumatoid arthritis (RA). In this study, we characterized specific pathogenic features of Th17 cells in RA. By using nano-string technology, we analyzed transcription of 419 genes in the peripheral blood CCR6(+)CXCR3(-) CD4(+) cells of 14 RA patients and 6 healthy controls and identified 109 genes discriminating Th17 cells of RA patients from the controls. Th17 cells of RA patients had an aggressive pathogenic profile and in addition to signature cytokines IL-17, IL-23 and IL-21, and transcriptional regulators RAR-related orphan receptor gamma of T cells (RORγt) and Janus kinase 2 (JAK2), they produced high levels of IL-23R, C-C chemokine ligand type 20 (CCL20), granulocyte-monocyte colony-stimulating factor (GM-CSF ) and transcription factor Tbet required for synovial homing ...
Granulocyte Macrophage Colony Stimulating Factor Market Insights: Global Industry Analysis, Market Drivers, Restraints, Opportunities, Applications, Trends And Forecasts 2020-2026
Production of neutralizing granulocyte-macrophage colony-stimulating (GM-CSF) antibodies in carcinoma patients followingGM-CSF combinaiton therapy. ...
49. Dillman R.O., Wiemann M., Nayak S.K. et al. Interferongamma or granulocyte-macrophage colony-stimulating factor administered as adjuvants with a vaccine of irradiated autologous tumor cells from short-term cell line cultures: a randomized phase 2 trial of the cancer biotherapy research group // J Immunother. - 2003. - Vol. 26, № 4. - Р. 367-373 ...
Several laboratories have developed culture systems that allow the generation of large numbers of human dendritic cells (DC) from monocytes using granulocyte-macrophage colony stimulating factor (GM-CSF), and interleukin-4 (IL-4). In this work we provided evidence that GM-CSF (100 ng/ml) in combination with a low concentration of IL-4 (5 ng/ml) was efficient in the generation of immature, non-adherent, monocyte-derived DC as the same concentration of GM-CSF, and ten times higher concentration of IL-4 (50 ng/ml). This conclusion was based on the similar phenotype profile of DC such as the expression of CD1a, CD80, CD86, and HLA-DR, down-regulation of CD14, and the absence of CD83, as well as on their similar allostimulatory activity for T cells. A higher number of cells remained adherent in cultures with lower concentrations of IL-4 than in cultures with higher concentrations of the cytokine. However, most of these adherent cells down-regulated CD14 and stimulated the proliferation of ...
The global protected feed amino acids market is expected to grow from USD 1,376.57 million 2017 to USD 2,120.57 million by the end of 2024 at a Compound Annual Growth Rate (CAGR) of 6.37%. Growing demand of Glutamic acid for enhancing flavoris one of the factors largely attributing to the growth of protected feed amino acids market globally The factors attributing to the growth of the market are growing demand of glutamic acid for enhancing flavor, need to control the rising human health issues, and increase demand for amino acid-based nutrition products. However, some factors such as high cost involved in r&d activities & production, and stringent regulations may hinder the market growth. The global protected feed amino acids market is expected to showcase the opportunities such as and growing demand in developing economies. In the near future, the market may face the possible challenges in the growth due to increasing usage of multi-page labeling, and negative perception of
Rabbit anti Human GM-CSF antibody recognizes human GM-CSF (granulocyte-macrophage colony-stimulating factor), a 14.6kDa haematopoietic gro
Miller, A M.; Page, P L.; Hartwell, B L.; and Robinson, S H., Inhibition of growth of normal murine granulocytes by cocultured acute leukemic cells. (1977). Subject Strain Bibliography 1977. 31 ...
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Selective expression of interleukin 10, interferon gamma, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies.: The variable clinica
Medical information for Granulocyte Macrophage Colony Stimulating Factor on Pediatric Oncall including Mechanism, Indication, Contraindications, Dosing, Adverse Effect, Interaction, Hepatic Dose.
Colony stimulating factors (CSFs) are proteins that stimulate production of immune (white blood) cells and provide life-saving protection against infection.
... that I should purify a colony-stimulating factor (CSF), a substance that stimulates the proliferation of blood cells in the ... Colony-stimulating factor derivatives. 1988 US Patent # 5,989,537: Inventors: Holly RD, Lok S, Foster DC, Kaushansky K, Kuijper ... Methods for stimulating granulocyte-macrophage lineage using thrombopoietin. 1999 US Patent #6,099,830: Inventors: Kaushansky K ... Methods for stimulating erythropoiesis using hematopoietic proteins. November 13, 2001 International Patent # WO 2004/026332A1 ...
Sometimes also called colony-stimulating factor, multi-CSF, mast cell growth factor, MULTI-CSF, MCGF; MGC79398, MGC79399: the ... IL-3 shares the β subunit with IL-5 and granulocyte-macrophage colony-stimulating factor (GM-CSF). This β subunit sharing ... "Entrez Gene: IL3 interleukin 3 (colony-stimulating factor, multiple)". Yang YC, Ciarletta AB, Temple PA, Chung MP, Kovacic S, ... Urdal DL, Price V, Sassenfeld HM, Cosman D, Gillis S, Park LS (1989). "Molecular characterization of colony-stimulating factors ...
... and colony stimulating factor 2. However, no functional sequence genetic polylmophisms are found within the promoter, exons, or ... granulocyte macrophage colony stimulating factor, interleukin 3, interleukin 5) that: a) cause bone marrow precursor cells, i.e ... of these genes or within the common gene enhancer for interleukin 3 or colony stimulating factor 2. This suggests that the ... The location of the causal factor can be used to classify eosinophilia into two general types: extrinsic, in which the factor ...
Undifferentiated bone marrow cells are cultured in the presence of macrophage colony-stimulating factor (M-CSF; CSF-1). M-CSF ... Hamilton, Thomas A.; Zhao, Chenyang; Pavicic, Paul G.; Datta, Shyamasree (2014-11-21). "Myeloid Colony-Stimulating Factors as ... Exogenous media containing growth factors and other serums must also be added to make the cells continually viable. Full growth ... Mature macrophages and fibroblasts, which may carry unwanted growth factors, are removed. Next, IL-3 and IL-1, two growth ...
Tumor cell lines overexpressing colony stimulating factors (e.g. G-CSF and GM-CSF) have long been used in in vivo models of ... Another important factor influencing the activity of MDSC is oppressive ROS. In addition to host-derived factors, pharmacologic ... The myeloid-differentiation cytokine GM-CSF is a key factor in MDSC production from bone marrow,[unreliable medical source?] ... MDSCs also accelerate angiogenesis, tumor progression and metastasis through the expression of cytokines and factors such as ...
This type is refractory to granulocyte colony-stimulating factor. There is an absence of lysosomes in fibroblasts and depletion ... Most cases of SCN respond to treatment with granulocyte colony-stimulating factor (filgrastim), which increases the neutrophil ... Over 90% of SCN responds to treatment with granulocyte colony-stimulating factor (filgrastim), which has significantly improved ... Neutrophil survival is normal.[citation needed] Regular administration of exogenous granulocyte colony-stimulating factor ( ...
Granulocyte colony-stimulating factor (G-CSF), available as filgrastim, can reduce the risk of infection. In some cases, G-CSF ... "Granulocyte colony-stimulating factor in glycogen storage disease type 1b. Results of the European Study on Glycogen Storage ... "Thrombocytopenia in association with splenomegaly during granulocyte-colony-stimulating factor treatment in mice is not caused ... "Different effects of granulocyte colony-stimulating factor and erythropoietin on erythropoiesis". Stem Cell Research & Therapy ...
It is a colony-stimulating factor that stimulates megakaryocyte production. It functions by stimulating ligands for interleukin ... a family of chimeric growth factors, supports megakaryocyte development through activation of IL-3 and c-Mpl ligand signaling ... cells with stem cell factor and promegapoietin". Exp Hematol. 28 (3): 335-46. doi:10.1016/S0301-472X(99)00152-6. PMID 10720698 ...
Moreover, tumor-produced colony stimulating factor-1 (CSF1), which regulates macrophage lineage, increases expression of Tie2 ... Cannarile MA, Weisser M, Jacob W, Jegg AM, Ries CH, Rüttinger D (July 2017). "Colony-stimulating factor 1 receptor (CSF1R) ... 3 June 2014). "Macrophage colony-stimulating factor augments Tie2-expressing monocyte differentiation, angiogenic function, and ... TAMs secrete the pro-angiogenic factors tumor necrosis factor α (TNFα), basic fibroblast growth factor, urokinase-type ...
During this time, the group led by Professor Donald Metcalf discovered and characterised the colony-stimulating factors (CSFs ... Later, Professor Donald Metcalf discovered and characterised colony-stimulating factors. As of 2015[update], the institute ...
In this context, the colony-stimulating factor 1 (CSF1)/colony-stimulating factor 1 receptor (CSF1R) axis has gained the most ... TGCT tumors grow due to genetic overexpression of colony stimulating factor 1. This causes colony-stimulating factor-1 receptor ... "Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy". Journal for Immunotherapy of Cancer. 5 (1): 53. doi ...
... (tradename Leukine) is a recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) that functions as ... "Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor". Blood. 92 (12): 4491-508. doi: ...
One notable example is the granulocyte macrophage colony-stimulating factor. There are two main categories of immunostimulants ... For example, female sex hormones are known to stimulate both adaptive and innate immune responses. Some autoimmune diseases ... Dorshkind, Kenneth; Horseman, Nelson D. (1 June 2000). "The Roles of Prolactin, Growth Hormone, Insulin-Like Growth Factor-I, ... Immunostimulants, also known as immunostimulators, are substances (drugs and nutrients) that stimulate the immune system by ...
Research regarding the production of granulocyte colony stimulating factor (G-CSF) is being conducted to investigate AMML ... "Production of granulocyte colony-stimulating factor by acute myelomonocytic leukemia cells". Leukemia Research. 12 (9): 745-750 ... Acquired predisposing factors include:Aplastic anemia, Chemotherapy, prenatal exposure to tobacco, marihuana, and alcohol. ... "Acute Myeloid Leukemia (AML) Subtypes and Prognostic Factors". www.cancer.org. Retrieved 2019-12-14. Shirafuji, Naoki; Asano, ...
Production is stimulated by granulocyte macrophage colony-stimulating factor (GM-CSF). There is some controversy over which ... CFU-GM, also known as granulocyte-macrophage progenitor (GMP), is a colony forming unit. It is derived from CFU-GEMM. The "GM" ... Nomenclature of hematopoietic colonies and lineages "Hem I WBC Morphology and Physiology". Archived from the original on ...
An eosinophil-specific colony-stimulating factor with activity for human cells". J. Exp. Med. 163 (5): 1085-1099. doi:10.1084/ ... and granulocyte-macrophage colony-stimulating factor (GM-CSF), which are often co-expressed in TH2 cells. Interleukin-5 is also ... and granulocyte-macrophage colony-stimulating factor (GM-CSF). Glycosylation of the Asn196 residue of the Rα subunit appears to ... IL-5 was originally discovered as an eosinophil colony-stimulating factor, is a major regulator of eosinophil accumulation in ...
There is limited evidence that granulocyte colony-stimulating factor may not hasten the resolution of diabetic foot ulcer ... Cochrane Wounds Group) (August 2013). "Granulocyte-colony stimulating factors as adjunctive therapy for diabetic foot ... Growth factors - there is some low-quality evidence that growth factors may increase the likelihood that diabetic foot ulcers ... Binding of growth factors is clearly an important role of perlecan in wound healing and angiogenesis. Poor wound healing in ...
El Ouakfaoui S, Heitz D, Paquin R, Beaulieu AD (February 1999). "Granulocyte-macrophage colony-stimulating factor modulates ...
Lin, E. Y.; Nguyen, A. V.; Russell, R. G.; Pollard, J. W. (2001). "Colony-stimulating factor 1 promotes progression of mammary ... Chemoattractive paracrine loop of colony-stimulating factor-1 (CSF-1) and EGF ligands between tumor-associated macrophages ( ... Vascular endothelial growth factor A (VEGF-A). The role of autocrine transforming growth factor beta 1(TGF-β1) signaling on ... The RMF/EG fibroblast must then be irradiated to allow the expression of key proteins and growth factors. After 4 weeks of ...
... tumor necrosis factor-alpha (TNF-alpha), Macrophage colony-stimulating factor (M-CSF/CSF1) and IL-1 and IL-6 contributing ... Lin EY, Nguyen AV, Russell RG, Pollard JW (March 2001). "Colony-stimulating factor 1 promotes progression of mammary tumors to ... Macrophages are stimulated by the low oxygen content of their surroundings to produce factors that induce and speed ... Macrophages also secrete a number of factors such as growth factors and other cytokines, especially during the third and fourth ...
Granulocyte-colony stimulating factor (G-CSF) is one possible treatment for neutropenia. Monitoring weight gain and growth is ...
Islet resident macrophages depend on the expression of colony stimulating factor (CSF1). Knockout mice for the CSF-1 gene cause ... Once activated, T-cells stimulate the adaptive immune system, which leads to the destruction of pancreatic islets due to an ... Brissova, M (2014). "Islet microenvironment, modulated by vascular endothelial growth growth factor-A signaling promotes B cell ...
"Human osteoblasts support hematopoiesis through the production of granulocyte colony-stimulating factor". J. Exp. Medicine. 179 ... and Osteopontin that can stimulate Wnt signaling in HSCs. Transcription factors such as PITX2 must be expressed in stromal ... These chimeric transcription factors can result in the improper repression or activation of the target gene, as well as the ... ECs located in this niche have been found to support new HSCs through the upregulation of factors such as p57 and IGF2. The ...
... it elicits its activity by binding the Colony stimulating factor 1 receptor. Messenger RNA (mRNA) expression of human IL-34 is ...
These include granulocyte colony-stimulating factor (GCSF) and myelomonocytic growth factor (MGF). GCSF acts in hematopoiesis ... Secondary structure analysis has suggested similarity to IL4 and granulocyte-macrophage colony stimulating factor (GMCSF). ... "Disulfide structures of human interleukin-6 are similar to those of human granulocyte colony stimulating factor". Archives of ... "Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in ...
Among the molecules that function as embryokines are insulin-like growth factor-1, cytokines (e.g., colony stimulating factor 2 ... actions of insulin-like growth factor-1, colony stimulating factor-2 and hyaluronan". Theriogenology. 76 (9): 1602-1609. doi: ... "Programming of the preimplantation embryo by the embryokine colony stimulating factor 2". Animal Reproduction Science. 149 (1-2 ... "Programming of the preimplantation embryo by the embryokine colony stimulating factor 2". Animal Reproduction Science. 149 (1-2 ...
Nagata identified Interferon in 1980 and Granulocyte colony-stimulating factor in 1986. He also identified a death factor (Fas ... "Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor". Nature. 319 (6052): 415-8. Bibcode: ... a novel member of the tumor necrosis factor family". Cell. 75 (6): 1169-78. doi:10.1016/0092-8674(93)90326-L. PMID 7505205. ...
Kaziro further broadened his research profile in 1986, when he began a genetic study on Granulocyte colony-stimulating factor ( ... "Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor". Nature. 319 (6052): 415-418. Bibcode ... Factor T is one of two complementary factors that are required for the elongation of peptide bonds on ribosomes within E. coli ... Factor T divides into Tu and Ts components, where in the presence of GTP, a Tu-Ts complex will dissociated to Tu and Ts, and ...
"CD34 expression by murine haematopoietic stem cells mobilized by granulocyte colony-stimulating factor". Blood. 96 (5): 1989-93 ... Kees UR, Ford J (Feb 1999). "Synergistic action of stem-cell factor and interleukin-7 in a human immature T-cell line". ... as a cell surface glycoprotein and functions as a cell-cell adhesion factor. It may also mediate the attachment of ... which are factor XIIIa-negative) in the interstitium and around the adnexa of dermis of skin, as well as cells in soft tissue ...
Ludwig researchers in Melbourne discovered and cloned the granulocyte-monocyte colony stimulating factor (GM-CSF) through a ... March 1985). "Structure and expression of the mRNA for murine granulocyte-macrophage colony stimulating factor". The EMBO ... The factor is essential to the maturation of key white blood cells, and has been used extensively over the past few decades to ... October 1985). "Purification and characterization of a human tumor necrosis factor from the LuKII cell line". Proceedings of ...
The body also stimulates eating by detecting a drop in cellular lipid levels (lipoprivation).[20] Both the brain and the liver ... The size of an animal is also a factor in determining diet type (Allen's rule). Since small mammals have a high ratio of heat- ... The only large insectivorous mammals are those that feed on huge colonies of insects (ants or termites).[33] ... In mice, MCH stimulates feeding and a mutation causing the overproduction of MCH led to overeating and obesity.[25] Orexin ...
The peripheral stem cell yield is boosted with daily subcutaneous injections of Granulocyte-colony stimulating factor, serving ... and the colony-stimulating factor used (G-CSF). G-CSF drugs include filgrastim (Neupogen, Neulasta), and lenograstim (Graslopin ...
Additional growth factors: Adrenomedullin. *Colony-stimulating factors (see here instead). *Connective tissue growth factor ( ... It is mainly used to treat cases of NSCLC that harbour mutations in the epidermal growth factor receptor (EGFR) gene.[5] ... Afatinib covalently binds to cysteine number 797 of the epidermal growth factor receptor (EGFR) via a Michael addition (IC50 = ... Phase II results for breast cancer that over-expresses the protein human epidermal growth factor receptor 2 (Her2-positive ...
株落刺激(英語:Template:Colony-stimulating factors). *血基質和卟啉 *代謝酶 ...
Retinoic acid suppresses osteoblast activity and stimulates osteoclast formation in vitro,[23] resulting in increased bone ... Barker ME, Blumsohn A (November 2003). "Is vitamin A consumption a risk factor for osteoporotic fracture?". The Proceedings of ... St Claire MB, Kennett MJ, Besch-Williford CL (July 2004). "Vitamin A toxicity and vitamin E deficiency in a rabbit colony". ...
Many Germans died of tropical disease, while others left the colonies to find better living conditions. The German colony of ... To stimulate the immigration to Brazil, the king offered several benefits for the Azorean couples. Between 1748 and 1756, six ... Immigration has been a very important demographic factor in the formation, structure and history of the population in Brazil, ... The first colonies to be populated by Italians were created in the highlands of Rio Grande do Sul (Serra Gaúcha). These were ...
... and customs to the colonies. The policy of association also affirmed the superiority of the French in the colonies, but it ... France's main goal was to stimulate the production of exports. Coffee, cocoa, and palm oil crops were soon planted along the ... and encouragement of foreign investment have been factors in the economic growth of Ivory Coast. In recent years, Ivory Coast ... It was a colony and an overseas territory under the Third Republic. In World War I, France organized regiments from Ivory Coast ...
Macroeconomic analysis also considers factors affecting the long-term level and growth of national income. Such factors include ... Risk aversion may stimulate activity that in well-functioning markets smooths out risk and communicates information about risk ... and for state regulation to impose protective tariffs on foreign manufactured goods and prohibit manufacturing in the colonies. ... The same factors are used to explain differences in the level of output per capita between countries, in particular why some ...
株落刺激(英語:Template:Colony-stimulating factors). *血基質和卟啉 *代謝酶 ...
Colony-stimulating factors. *G-CSF *Filgrastim / Lipegfilgrastim / Pegfilgrastim. *Lenograstim. *Eflapegrastim. *GM-CSF * ...
株落刺激(英語:Template:Colony-stimulating factors). *血紅素和卟啉 *代謝酶 ... platelet activating factor)和其他物
Jolivétte, Andrew (2012). Obama and the Biracial Factor: The Battle for a New American Majority. Policy Press. p. xiii. ISBN ... Additionally, many Afro-Spaniards born in Spain are from the former Spanish colony Equatorial Guinea. Today, there are an ... in order to stimulate a "black" consciousness and identity.[174] ... Other social factors, such as illiteracy and education levels, ... and other factors resulted in a population in which 6.2% of the population identified as black, 40% as pardo, and 55% as white ...
... granulocyte macrophage-colony stimulating factor (GM-CSF) - granulocyte-colony stimulating factor (G-CSF) - granulocytopenia ... host factors - HPTN - HPV - HRSA - HTLV-I - HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) - HTLV-II - ...
Additional growth factors: Adrenomedullin. *Colony-stimulating factors (see here instead). *Connective tissue growth factor ( ... BDNF, brain-derived neurotrophic factor, ANON2, BULN2, Brain-derived neurotrophic factor, brain derived neurotrophic factor. ... Brain-derived neurotrophic factor (BDNF), or abrineurin,[5] is a protein[6] that, in humans, is encoded by the BDNF gene.[7][8] ... which are related to the canonical nerve growth factor. Neurotrophic factors are found in the brain and the periphery. BDNF was ...
Hematopoietic (KITLG, Colony-stimulating factor) · SPP1. By function/. cell. proinflammatory cytokine (IL1, TNFA) Monokine · ...
Colony collapse disorder[edit]. Main article: Colony collapse disorder. Primarily in places where the bee was imported by ... but others indicate egg viability as the key factor in eliciting the behavior.[67][68] Worker policing is an example of forced ... and alarmed bees release a pheromone that stimulates the attack response in other bees. The different species of honey bees are ... of European honey bee colonies have occurred in North America. This has been dubbed "colony collapse disorder" (CCD) and was at ...
... granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor for priming leukocyte-mediated ...
Granulocyte macrophage colony-stimulating factor. *Milodistim. *Molgramostim. *Regramostim. *Sargramostim. *Antibodies: ... tumor necrosis factor-activated receptor activity. • nerve growth factor binding. Cellular component. • cytoplasm. • integral ... "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". The ... "Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation". The ...
Additional growth factors: Adrenomedullin. *Colony-stimulating factors (see here instead). *Connective tissue growth factor ( ... Pegaptanib is a pegylated anti-vascular endothelial growth factor (VEGF) aptamer, a single strand of nucleic acid that binds ...
Additional growth factors: Adrenomedullin. *Colony-stimulating factors (see here instead). *Connective tissue growth factor ( ... Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In ... Chemically inhibiting the PI3K pathway in PDGF-stimulated cells negates the differential effect between the two growth factors ... Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)[16][17] which are ...
On macrophages: stimulates phagocytosis, and production of IL-1 oxidants and the inflammatory lipid Prostaglandin E2 (PGE2) ... TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha. ... Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) ... reported another cytotoxic factor produced by macrophages and named it tumor necrosis factor (TNF).[14] Both factors were ...
Additional growth factors: Adrenomedullin. *Colony-stimulating factors (see here instead). *Connective tissue growth factor ( ... It is believed to be a major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in ... A major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in adults."[5] ... A major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in adults. ...
A famine is a widespread scarcity of food,[1] caused by several factors including war, inflation, crop failure, population ... This stimulated the first mass movements to end famine across the world. ... the drought was brief the main cause of death in Rwanda was due to Belgian prerogatives to acquisition grain from their colony ... Numerous factors make the food security situation in Africa tenuous, including political instability, armed conflict and civil ...
Additional growth factors: Adrenomedullin. *Colony-stimulating factors (see here instead). *Connective tissue growth factor ( ... BDNF, brain-derived neurotrophic factor, ANON2, BULN2, Brain-derived neurotrophic factor, brain derived neurotrophic factor. ... Brain-derived neurotrophic factor, also known as BDNF, is a protein[5] that, in humans, is encoded by the BDNF gene.[6][7] BDNF ... growth factor activity. Cellular component. • cytoplasm. • perinuclear region of cytoplasm. • mitochondrion. • nuclear speck. • ...
Contrasting antibiotics, probiotics were defined as microbially derived factors that stimulate the growth of other ... rhamnosus or Saccharomyces boulardii at 5 to 40 billion colony-forming units/day, given the modest number needed to treat and ... The term was used again[61] to describe tissue extracts that stimulated microbial growth. The term probiotics was taken up by ... Lilly DM, Stillwell RH (1965). "Probiotics: Growth-promoting factors produced by microorganisms". Science. 147 (3659): 747-748 ...
... as persistent joint pain has been associated with elevated levels of IL-6 and granulocyte-macrophage colony-stimulating factor ... January 2010). "Factors associated with persistence of arthralgia among Chikungunya virus-infected travellers: report of 42 ... mouse studies suggest that IPS-1 is an important factor,[48] and that IRF3 and IRF7 are important in an age-dependent manner.[ ... "Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock". Journal of Virology. 86 ...
Granulocyte-macrophage colony-stimulating factor. *Interferon-gamma. References[edit]. *^ Julius M. Cruse; Robert Edwin Lewis ( ...
Additional growth factors: Adrenomedullin. *Colony-stimulating factors (see here instead). *Connective tissue growth factor ( ...
We think the same factors which act today also acted in the past. ... It was probably caused by cyanobacteria, whose colonies ... It cleared up many confusions, and was directly responsible for stimulating a great deal of research after WWII. ... The variety of genes (alleles) carried in natural populations is a key factor in evolution. ...
An Account of the English Colony in New South Wales, Volume 2. Retrieved 5 July 2017 - via Internet Archive.. ... which continuously stimulate its mechanoreceptors.[37] Experiments have shown the platypus will even react to an "artificial ... and this pattern does not seem to follow any particular climatic rule and may be due to other environmental factors, such as ... In David Collins's account of the new colony 1788-1801, he describes coming across "an amphibious animal, of the mole species ...
Source for information on colony-stimulating factor: A Dictionary of Biology dictionary. ... Any of several cytokines that stimulate development of certain types of blood cells from progenitor cells in the bone marrow ... colony-stimulating factor (CSF) Any of several cytokines that stimulate development of certain types of blood cells from ... colony-stimulating factor. Updated About encyclopedia.com content Print Article Share Article ...
Colony-stimulating factors include: CSF1 - macrophage colony-stimulating factor CSF2 - Granulocyte macrophage colony- ... was called macrophage colony-stimulating factor, for granulocytes, granulocyte colony-stimulating factor, and so on. The colony ... stimulating factors (also called GM-CSF and sargramostim) CSF3 - Granulocyte colony-stimulating factors (also called G-CSF and ... The name "colony-stimulating factors" comes from the method by which they were discovered. Hematopoietic stem cells were ...
The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine ... It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 ... "Entrez Gene: CSF1 colony stimulating factor 1 (macrophage)". Jang MH, Herber DM, Jiang X, Nandi S, Dai XM, Zeller G, Stanley ER ... Macrophage+Colony-Stimulating+Factor at the US National Library of Medicine Medical Subject Headings (MeSH) Overview of all the ...
... Xi Ling Liu,1 Xiang Hu,1 Wei Xin Cai,2,3 ... Xi Ling Liu, Xiang Hu, Wei Xin Cai, Weijia William Lu, and Li Wu Zheng, "Effect of Granulocyte-Colony Stimulating Factor on ...
macrophage colony stimulating factor synonyms, macrophage colony stimulating factor pronunciation, macrophage colony ... stimulating factor translation, English dictionary definition of macrophage colony stimulating factor. n. 1. One that actively ... contributes to an accomplishment, result, or process: Surprise is the greatest factor in war . See Synonyms at element. 2. a. ... factor. [ˈfæktəʳ]. A. N. 1. (= consideration) → factor m. safety factorfactor m de seguridad. the human factor → el factor ...
Colony Stimulating Factors. Class Summary. These agents are used to manage anemia related to chronic renal failure, rheumatoid ... Nutritional anemia can be treated with supplements of deficient factors.. Recombinant erythropoietin has been useful in ... Deficiency may result from intrinsic factor deficiency (pernicious anemia), partial or total gastrectomy, or diseases of the ... Its biological activity mimics human urinary EPO, which stimulates division and differentiation of committed erythroid ...
Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition.. Mok S1,2, Tsoi J3, Koya RC4 ... The production of colony stimulating factor 1 (CSF-1) in tumors recruits myeloid cells such as M2-polarized macrophages and ... Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition ... Inhibition of colony stimulating factor-1 receptor improves antitumor efficacy of BRAF inhibition ...
Granulocyte colony-stimulating factor treatment for cyclophosphamide-induced severe neutropenia in Wegeners granulomatosis.. ... To examine the efficacy and safety of recombinant human granulocyte colony-stimulating factor (rHuG-CSF) in the treatment of ...
Granulocyte macrophage colony-stimulating factor. Granulocyte colony-stimulating factor. Macrophage colony-stimulating factor. ... CSF1 - macrophage colony-stimulating factor. *CSF2 - Granulocyte macrophage colony-stimulating factors (also called GM-CSF and ... Colony-stimulating factors (CSFs) are secreted glycoproteins which bind to receptor proteins on the surfaces of hemopoietic ... Colony-Stimulating+Factors at the US National Library of Medicine Medical Subject Headings (MeSH) ...
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is often used to treat leucopenia. Other haematopoietins may increase ... Granulocyte-colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) for sepsis: a meta- ... Haematopoietic growth factor Granulocyte-macrophage colony-stimulating factor Innate immunity Adaptive immunity ... Macrophage tumor necrosis factor-alpha induces epithelial expression of granulocyte-macrophage colony-stimulating factor: ...
Purified human granulocyte-macrophage colony-stimulating factor: direct action on neutrophils. By JC Gasson, RH Weisbart, SE ... Purified human granulocyte-macrophage colony-stimulating factor: direct action on neutrophils. By JC Gasson, RH Weisbart, SE ... Purified human granulocyte-macrophage colony-stimulating factor: direct action on neutrophils Message Subject. (Your Name) has ... The NIF-T was found to potently stimulate the growth of granulocyte and macrophage colonies from human bone marrow and colony ...
drug JNJ-40346527 on CSF-1R (colony stimulating factor-1 receptor), which is a protein on the outside of cells present in the ... MIcroglial Colony Stimulating Factor-1 Receptor (CSF1R) in Alzheimers Disease. 2019-10-15 11:10:59 , BioPortfolio ... More From BioPortfolio on "MIcroglial Colony Stimulating Factor-1 Receptor (CSF1R) in Alzheimers Disease". *Related Companies* ... Home » Topics » Mild Cognitive impairment » Research » MIcroglial Colony Stimulating Factor-1 Receptor (CSF1R) in Alzheimers ...
GM-CSF stands for Granulocyte-Macrophage-Macrophage Colony-Stimulating Factor (pharmacology). GM-CSF is defined as Granulocyte- ... Macrophage-Macrophage Colony-Stimulating Factor (pharmacology) very rarely. ... How is Granulocyte-Macrophage-Macrophage Colony-Stimulating Factor (pharmacology) abbreviated? ... Macrophage-Colony_Stimulating-Factor-(pharmacology)-(GM_CSF).html ... Macrophage-Colony_Stimulating-Factor-(pharmacology)-(GM_CSF). ...
Granulocyte macrophage colony-stimulating factor. Granulocyte colony-stimulating factor. Macrophage colony-stimulating factor. ... The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine ... It is one of the three experimentally described colony-stimulating factors. M-CSF binds to the colony stimulating factor 1 ... Stanley ER, Berg KL, Einstein DB, Lee PS, Yeung YG (1995). "The biology and action of colony stimulating factor-1". Stem Cells ...
Colony-stimulating factors. Class Summary. These agents act as a hematopoietic growth factor that stimulates the development of ... Granulocyte colony-stimulating factor that activates and stimulates production, maturation, migration, and cytotoxicity of ... Antineoplastic-induced vomiting is stimulated through the chemoreceptor trigger zone (CTZ), which then stimulates the vomiting ... With serotonin release and subsequent binding to 5-HT3-receptors, vagal neurons are stimulated and transmit signals to the VC, ...
... granulocyte colony stimulating factor include Colony Forming Cell (CFC) Assay for Human Hematopoietic Cells, Proliferation ...
Macrophage colony-stimulating factor 1Add BLAST. 520. ChainiPRO_0000296232. 33 - 447. Processed macrophage colony-stimulating ... macrophage colony-stimulating factor signaling pathway Source: BHF-UCL ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a ... "The cell surface form of colony-stimulating factor-1 is biologically active in bone in vivo.". Yao G.Q., Wu J.J., Sun B.H., ... "The cell surface form of colony-stimulating factor-1 is biologically active in bone in vivo.". Yao G.Q., Wu J.J., Sun B.H., ...
Interleukin-1 boosts the effects of granulocyte colony-stimulating factor and granulocyte/macrophage colony-stimulating factor ... Most of these factors are now available as recombinant human colony-stimulating factors, and preclinical and clinical testing ... Hematopoietic colony-stimulating factors coordinate the proliferation and maturation of bone marrow and peripheral blood cells ... Granulocyte/macrophage colony-stimulating factor has similar biological properties but may also improve eosinophil ...
Granulocyte-macrophage colony-stimulating factor (GM-CSF) can stimulate proliferation of leukemic blasts and sensitize these ... Granulocyte-macrophage colony-stimulating factor (GM-CSF) can stimulate proliferation of leukemic blasts and sensitize these ... Granulocyte-macrophage colony-stimulating factor (GM-CSF) priming with successive concomitant low-dose Ara-C for elderly ... Rossi, H., ODonnell, J., Sarcinelli, F. et al. Granulocyte-macrophage colony-stimulating factor (GM-CSF) priming with ...
What is Colony-stimulating factors? Meaning of Colony-stimulating factors as a legal term. What does Colony-stimulating factors ... Definition of Colony-stimulating factors in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) secretion by ... Colony-stimulating factors legal definition of Colony-stimulating factors https://legal-dictionary.thefreedictionary.com/Colony ...
What is Colony-stimulating factor? Meaning of Colony-stimulating factor as a legal term. What does Colony-stimulating factor ... Definition of Colony-stimulating factor in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... Related to Colony-stimulating factor: Granulocyte colony-stimulating factor, macrophage colony stimulating factor, colony ... Colony-stimulating factor legal definition of Colony-stimulating factor https://legal-dictionary.thefreedictionary.com/Colony- ...
Because granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhance ... Because granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhance ... Granulocyte and granulocyte-macrophage colony-stimulating factors in cord and maternal serum at delivery Pediatr Res. 1994 Feb; ...
Synonyms: CSF, Colony-stimulating factor, GM-CSF, GMCSF, Granulocyte-macrophage colony-stimulating factor, ... ... When stimulated with granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-4 (IL-4), monocytes yield DCs [ ... Interleukin-3 (IL-3) and granulocyte-monocyte-colony-stimulating factor (GM-CSF) stimulate proliferation of human acute myeloid ... Interleukin-3 (IL3) and granulocyte/macrophage colony-stimulating factor (CSF2) stimulate proliferation and differentiation of ...
Granulocyte-colony Stimulating Factor for Stem Cells Therapy for Acute Ischemic Stroke (STEMTHER). The safety and scientific ... Granulocyte-colony stimulating factor (G-CSF) was used in some clinical trials without following autological transplantation. ... The aim of the study is to investigate treatment with Leukostim (Filgrastim; granulocyte-colony stimulating factor; G-CSF) for ... Open Prospective Randomized Controlled Trial of Efficacy and Safety of Granulocyte-colony Stimulating Factor Leukostim for ...
Efficacy of Granulocyte Colony Stimulating Factor (GCSF) In Patients With Dystrophic Epidermolysis Bullosa. The safety and ... Granulocyte Colony Stimulating Factor (GCSF): G-CSF 10mcg/kg/d SQ for 7 days ... Granulocyte Colony Stimulating Factor (GCSF): G-CSF 10mcg/kg/d SQ for 7 days ... Granulocyte Colony Stimulating Factor (GCSF): G-CSF 10mcg/kg/d subcutaneously for 7 days ...
Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor. ... Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor. Display Files *FASTA ... R-Factor (All). R-Factor (Observed). R-Work. R-Free. R-Free Selection Details. ...
Colony-stimulating factor levels were measured by a semi-solid tissue culture colony assay with murine bone marrow as the ... Abstract Studies have been done to determine the levels of human urinary granulocyte colony-stimulating factor in Egyptian ... Colony-stimulating factor levels were measured by a semi-solid tissue culture colony assay with murine bone marrow as the ... Urinary Granulocyte Colony-Stimulating Factor in Bilharziasis * * Lotfy Abdel Naby Mahmoud, William A. Robinson, Maureen A. ...
... recombinant human granulocyte/macrophage colony-stimulating factor) in Daviss Drug Guide including dosage, side effects, ...
What is eosinophil colony-stimulating factor? Meaning of eosinophil colony-stimulating factor medical term. What does ... Looking for online definition of eosinophil colony-stimulating factor in the Medical Dictionary? eosinophil colony-stimulating ... Fletcher factor prekallikrein.. granulocyte colony-stimulating factor (G-CSF) a colony-stimulating factor that stimulates ... Colony-stimulating factor, Contact inhibiting factor, Conversion factor, Cord factor, DAF factor, Dilution factor, Elongation ...
Purification and some properties of the colony stimulating factor from medium conditioned by mouse L cells. j BioL Chem ... The proliferation of microglial cells is stimulated by colony-stimulating factor 1 (CSF-1), an astrocyte-produced growth factor ... The proliferation of microglial cells is stimulated by colony-stimulating factor 1 (CSF-1), an astrocyte-produced growth factor ... MURINE EOSINOPHIL DIFFERENTIATION FACTOR An Eosinophil-specific Colony-stimulating Factor with Activity for by Human Cells, F. ...
  • Vaccination with irradiated granulocyte-macrophage colony-stimulating factor (GM-CSF)-secreting gene-transduced cancer vaccines induces tumoricidal immune responses. (aacrjournals.org)
  • Colony‑stimulating factor 1 receptor inhibition blocks macrophage infiltration and endometrial cancer cell proliferation. (nih.gov)
  • Genetic variants in macrophage colony-stimulating factor are associated with risk of renal cell carcinoma in a Chinese population. (nih.gov)
  • The substance that was found to stimulate formation of colonies of macrophages, for instance, was called macrophage colony-stimulating factor, for granulocytes, granulocyte colony-stimulating factor, and so on. (wikipedia.org)
  • Not to be confused with granulocyte macrophage colony-stimulating factor . (wikipedia.org)
  • The colony stimulating factor 1 (CSF1), also known as macrophage colony-stimulating factor (M-CSF), is a secreted cytokine which causes hematopoietic stem cells to differentiate into macrophages or other related cell types. (wikipedia.org)
  • Macrophage colony-stimulating factor has been shown to interact with PIK3R2. (wikipedia.org)
  • The hematopoietic growth factor, granulocyte macrophage colony-stimulating factor (GM-CSF), is considered to play a central role in maintaining chronic inflammation. (rupress.org)
  • The hematopoietic growth factor, GM-CSF, was first considered to be proinflammatory because of its ability to stimulate macrophage plasminogen activator activity ( 8 ). (rupress.org)
  • Surfactant metabolism in transgenic mice after granulocyte macrophage-colony stimulating factor ablation. (nih.gov)
  • Mice made granulocyte macrophage-colony stimulating factor (GM-CSF)-deficient by homologous recombination maintain normal steady-state hematopoiesis but have an alveolar accumulation of surfactant lipids and protein that is similar to pulmonary alveolar proteinosis in humans. (nih.gov)
  • Lieschke GJ, Burgess AW (1992) Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. (springer.com)
  • Tani K, Ozawa K, Ogura H et al (1990) Expression of granulocyte and granulocyte-macrophage colony-stimulating factors by human non-hematopoietic tumor cells. (springer.com)
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) is often used to treat leucopenia. (springer.com)
  • Harvesting and enrichment of hematopoietic progenitor cells mobilized into the peripheral blood of normal donors by granulocyte-macrophage colony-stimulating factor (GM-CSF) or G-CSF: potential role in allogeneic marrow transplantation. (springer.com)
  • Emerging applications of recombinant human granulocyte-macrophage colony-stimulating factor. (springer.com)
  • The NIF-T was found to potently stimulate the growth of granulocyte and macrophage colonies from human bone marrow and colony formation by the KG-1 myeloid leukemia cell line. (sciencemag.org)
  • Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. (uniprot.org)
  • Granulocyte and granulocyte/macrophage colony-stimulating factors have been the most extensively studied to date. (hindawi.com)
  • Granulocyte/macrophage colony-stimulating factor has similar biological properties but may also improve eosinophil proliferation and function, and platelet cell recovery after myelotoxic bone marrow injury, Interleukin-1 boosts the effects of granulocyte colony-stimulating factor and granulocyte/macrophage colony-stimulating factor, but also may promote the resolution of established infections in conjunction with antibiotics. (hindawi.com)
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) can stimulate proliferation of leukemic blasts and sensitize these cells to the cytotoxic effects of S-phase-specific drugs. (nature.com)
  • 8 , 9 Human granulocyte-macrophage colony-stimulating factor (GM-CSF) is a glycoprotein which supports proliferation and differentiation of a broad range of hematologic, especially myeloid, precursor cells. (nature.com)
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony-stimulating factor (G-CSF) secretion by adherent monocytes measured by quantitative immunoassays. (thefreedictionary.com)
  • Derman, "A randomized trial of granulocyte-macrophage colony-stimulating factor in neonates with sepsis and neutropenia," Pediatrics, vol. (thefreedictionary.com)
  • Local transgenic expression of granulocyte-macrophage colony-stimulating factor initiates autoimmunity. (thefreedictionary.com)
  • Simultaneous antagonism of interleukin-5, granulocyte-macrophage colony-stimulating factor , and interleukin-3 stimulation of human eosinophils by targeting the common cytokine binding site of their receptors. (thefreedictionary.com)
  • Some grade 2 toxicities were seen at higher doses of recombinant fowlpox granulocyte-macrophage colony-stimulating factor , but there were no significant toxicities (J. (thefreedictionary.com)
  • Because granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) enhance granulocyte and macrophage number and function, their use in the management of neonatal sepsis may be beneficial. (nih.gov)
  • The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer. (pnas.org)
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin 3 (IL-3) are pleiotropic hemopoietic growth factors whose genes are closely linked and induced in T lymphocytes in a cyclosporin A (CsA)-sensitive fashion. (pnas.org)
  • Citation Query Factors regulating macrophage production and growth. (psu.edu)
  • Factors regulating macrophage production and growth. (psu.edu)
  • This study investigates the potential for granulocyte-macrophage colony-stimulating factor (GM-CSF) to effect a clinically relevant increase in neutrophil number when used prophylactically in high-risk preterm neonates, and assesses its safety in this population. (aappublications.org)
  • The hemopoietic colony-stimulating factors, granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF), have become standard treatment for preventing chemotherapy-induced neutropenia and accelerating neutrophil recovery after marrow transplantation. (aappublications.org)
  • Outside of the setting of a clinical trial, few data support the use of granulocyte-macrophage colony-stimulating factor (GM-CSF) in patients with ALL. (medscape.com)
  • Regulation of wound healing by granulocyte-macrophage colony-stimulating factor after vocal fold injury. (sigmaaldrich.com)
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) facilitates epithelial wound healing, and recently, growth factor therapy has been applied to promote tissue repair. (sigmaaldrich.com)
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF), a 22 kDa glycoprotein, was first described as an in vitro inducer of differentiation and proliferation of bone marrow progenitor cells into distinct colonies, including granulocytes and macrophages. (dovepress.com)
  • SDS-PAGE of Human Macrophage Colony Stimulating Factor Recombinant Protein SDS-PAGE of Human Macrophage Colony Stimulating Factor Recombinant Protein. (antibodies-online.com)
  • Macrophage Colony Stimulating Factor purity was determined to be greater than 97% as determined by HpLC, analysis by UV-Spectroscopy at 280nm, and by reducing and non-reducing SDS-pAGE. (antibodies-online.com)
  • Application Note: Macrophage Colony Stimulating Factor Recombinant Protein is suitable as a control for polyclonal or monoclonal anti-Macrophage Colony Stimulating Factor in immunological assays. (antibodies-online.com)
  • In humans, these proteins include granulocyte-macrophage colony stimulating factor (GM-CSF), a glycoprotein required for the production of granulocytes and macrophages from normal bone marrow which also appears to regulate the activity of mature, differentiated granulocytes and macrophages. (google.com)
  • Other human CSFs (hCSFs) include macrophage CSF (M-CSF or CSF-1), which induces the selective proliferation of macrophages, granulocyte CSF (G-CSF), which stimulates development of granulocytes, and burst promoting activity (BPA), which induces development of erythroid cell progenitors into hemoglobin-containing cells. (google.com)
  • Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) is a cytokine that plays a key role in the immune/inflammatory cascade. (cags.org.ae)
  • Gene Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts that functions as a cytokine. (gentaur.com)
  • granulocyte-macrophage colony-stimulating factor is a topic covered in the Taber's Medical Dictionary . (tabers.com)
  • Taber's Online , www.tabers.com/tabersonline/view/Tabers-Dictionary/758890/all/granulocyte_macrophage_colony_stimulating_factor. (tabers.com)
  • Lachmann G, Kurth J, von Haefen C, Yuerek F, Wernecke KD, Spies C. In vivo application of Granulocyte-Macrophage Colony-stimulating Factor enhances postoperative qualitative monocytic function. (medsci.org)
  • Granulocyte macrophage colony-stimulating factor (GM-CSF) can be used as a potent stimulator for immune suppressed patients as defined by a decrease of human leukocyte antigen-D related expression on monocytes (mHLA-DR) after surgery. (medsci.org)
  • Recombinant human granulocyte-macrophage colony stimulating factor (sargramostim) as an alternative therapy for fistulizing Crohn's disease. (thefreelibrary.com)
  • We examined whether interferon (IFN)-gamma, a representative Th1 cytokine, modifies the effector functions of human eosinophils stimulated by granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-5. (unboundmedicine.com)
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) has been implicated as an important mediator in the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD). (bmj.com)
  • Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a major regulator of inflammatory cells of the myeloid lineage and has been implicated in asthma and COPD. (bmj.com)
  • It has previously been shown that human granulocyte-macrophage colony-stimulating factor (GM-CSF) can be fused to a truncated diphtheria toxin (DT) to produce a recombinant fusion toxin that kills GM-CSF receptor-bearing cells. (bloodjournal.org)
  • We chose to use diphtheria toxin as the toxophore and human granulocyte-macrophage colony-stimulating factor (GM-CSF) as the haptophore or ligand. (bloodjournal.org)
  • Global Markets Directs, Granulocyte Macrophage Colony Stimulating Factor Receptor Subunit Alpha (CDw116 or CD116 or CSF2RA) - Pipeline Review, H2 2016, provides in depth analysis on Granulocyte Macrophage Colony Stimulating Factor Receptor Subunit Alpha (CDw116 or CD116 or CSF2RA) targeted pipeline therapeutics. (researchmoz.us)
  • The report provides comprehensive information on the Granulocyte Macrophage Colony Stimulating Factor Receptor Subunit Alpha (CDw116 or CD116 or CSF2RA), targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. (researchmoz.us)
  • Additionally, the report provides an overview of key players involved in Granulocyte Macrophage Colony Stimulating Factor Receptor Subunit Alpha (CDw116 or CD116 or CSF2RA) targeted therapeutics development and features dormant and discontinued projects. (researchmoz.us)
  • To evaluate a dose intensive chemotherapy regimen for the treatment of locally advanced and metastatic breast cancer using granulocyte-macrophage colony-stimulating factor (GM-CSF) to ameliorate chemotherapy-induced toxicity. (knowcancer.com)
  • Objectives To determine the safety, tolerability and signs of efficacy of MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF), in patients with rheumatoid arthritis (RA). (bmj.com)
  • In a pilot study with five oral cancer patients undergoing radiotherapy (RT) three were given Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) as a protective agent to reduce the mucosal inflammation during radiotherapy. (amrita.edu)
  • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. (rupress.org)
  • Using granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin 4 we have established dendritic cell (DC) lines from blood mononuclear cells that maintain the antigen capturing and processing capacity characteristic of immature dendritic cells in vivo. (rupress.org)
  • Granulocyte-macrophage colony-stimulating factor: involvement in control of Trypanosoma cruzi infection in mice. (asm.org)
  • Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hemopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell (usually white blood cells. (wikipedia.org)
  • M-CSF binds to the colony stimulating factor 1 receptor. (wikipedia.org)
  • drug JNJ-40346527 on CSF-1R (colony stimulating factor-1 receptor), which is a protein on the outside of cells present in the brain. (bioportfolio.com)
  • G-CSF stimulates the proliferation, survival, and maturation of cells committed to the neutrophilic granulocyte (NG) lineage through binding to the specific G-CSF receptor (G-CSFR). (ahajournals.org)
  • GM-CSF carries out this function by activating signaling pathways via a cell surface receptor known as the Colony Stimulating Factor 2 Receptor. (cags.org.ae)
  • 8 GM-CSF is a pleiotrophic and proinflammatory cytokine that stimulates myelopoiesis, promotes leucocyte survival and activation, and regulates mucosal immunity and inflammation in part via modulation of Toll-like receptor-4 9 and neutrophil function. (bmj.com)
  • Microglial stimulation of glioblastoma invasion involves epidermal growth factor receptor (EGFR) and colony stimulating factor 1 receptor (CSF-1R) signaling. (sigmaaldrich.com)
  • Pharmacological inhibition of epidermal growth factor receptor (EGFR) strongly inhibited microglia-stimulated invasion. (sigmaaldrich.com)
  • Furthermore, blockade of colony stimulating factor 1 receptor (CSF-1R) signaling using ribonucleic acid (RNA) interference or pharmacological inhibitors completely inhibited microglial enhancement of glioblastoma invasion. (sigmaaldrich.com)
  • We now report that DT388-GM-CSF induces apoptosis and inhibition of colony formation in semisolid medium in receptor positive cells, and that the induction of apoptosis correlates with GM-CSF-receptor occupancy at low ligand concentrations. (bloodjournal.org)
  • DT388-GM-CSF at 4 × 10 −9 mol/L inhibited colony formation 1.5 to 3.0 logs for receptor positive cell lines. (bloodjournal.org)
  • M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. (wikipedia.org)
  • M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity. (wikipedia.org)
  • A protein that stimulates white blood cells, especially granulocytes, macrophages, and cells that become platelets, to multiply and mature. (nih.gov)
  • A naturally occurring protein that stimulates the production of granulocytes and macrophages by stem cells and is used as a drug by some immunosuppressed individuals. (wordnik.com)
  • It is assumed that about 20% of cases are related to autoimmune disorders and about 40-50% of cases are unexplained RM G-CSF (Granulocyte Colony-stimulating Factor ) is a glycoprotein that is secreted from endothelial cells, macrophages and some other immune system cells (6). (thefreedictionary.com)
  • Also the recently reported G-CSF-induced maturation of monocytes/macrophages [ 7 ] can be relevant to the role of this growth factor in acute radiation syndrome. (mdpi.com)
  • Granulocyte Colony-Stimulating Factor, or G-CSF, is a growth factor that is considered the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. (cellsciences.com)
  • Infliximab is a chimeric monoclonal immunoglobulin antibody (igGl) against tumor necrosis factor, a product of macrophages (3). (thefreelibrary.com)
  • We investigated how microglia, the resident macrophages of the brain, stimulate glioblastoma cell invasion. (sigmaaldrich.com)
  • 2-D-Deoxyglucose (2-dGlc) uptake and accumulation into rat peritoneal macrophages was increased by colony-stimulating factor (mCSF) by stimulating the coupling between endofacial hexokinase activity and the sugar transporter. (portlandpress.com)
  • Colony stimulating factors (CSFs) are proteins that stimulate production of immune (white blood) cells and provide life-saving protection against infection. (edu.au)
  • CSFs are hormone-like proteins that stimulate the production of infection-fighting immune cells. (edu.au)
  • Because CSFs can stimulate the production of immune cells, they are used as medicines to boost the production of white blood cells . (edu.au)
  • Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). (routledge.com)
  • Colony-stimulating factors (CSFs): Cytokines that stimulate the production of blood cells. (thefreedictionary.com)
  • For example, growth and differentiation of hematopoeitic cells is mediated by a number of glycoproteins collectively referred to as colony stimulating factors or CSFs. (google.com)
  • Freeze thaw will destroy a percentage in every cycle and should be avoided.Colonies can be formed by stimulating factors or recombinant GM-CSF and CSFs activity expressed in Units compared to a standard.Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (gentaur.com)
  • G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils . (wikipedia.org)
  • It also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. (wikidoc.org)
  • Hematopoietic colony-stimulating factors coordinate the proliferation and maturation of bone marrow and peripheral blood cells during normal hematopoiesis. (hindawi.com)
  • 10 By stimulating proliferation of leukemic blasts, GM-CSF can sensitize these cells to the cytotoxic effects of S-phase-specific drugs, such as cytarabine. (nature.com)
  • In vitro studies have generally confirmed the impact of growth factors on leukemic cell proliferation and sensitivity to chemotherapy. (nature.com)
  • Growth factors are polypeptides essentially involved in regulating survival, proliferation, maturation, and outgrowth of developing neuronal cells. (ahajournals.org)
  • Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. (gentaur.com)
  • Identification of a lymphokine that stimulates eosinophil differentiation in vitro. (psu.edu)
  • 4 GM-CSF can also act on relatively early progenitor cells and interacts with erythropoietin to stimulate eosinophil and megakaryocyte colony formation in vitro. (dovepress.com)
  • colony-stimulating factor ( CSF ) Any of several cytokines that stimulate development of certain types of blood cells from progenitor cells in the bone marrow and in other tissues. (encyclopedia.com)
  • Granulocyte-colony stimulating factor ( G-CSF or GCSF ), also known as colony-stimulating factor 3 ( CSF 3 ), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream . (wikipedia.org)
  • G-CSF stimulates the bone marrow to make more blood cells. (macmillan.org.uk)
  • during treatment with chemotherapy to stimulate the bone marrow to make white blood cells, called neutrophils. (macmillan.org.uk)
  • This will stimulate your bone marrow to make stem cells and increase the number of stem cells in the blood. (macmillan.org.uk)
  • Its biological activity mimics human urinary EPO, which stimulates division and differentiation of committed erythroid progenitor cells and induces the release of reticulocytes from bone marrow into the blood stream. (medscape.com)
  • Granulocyte colony-stimulating factor (G-CSF) is an endogenous hematopoietic growth factor that induces terminal differentiation and release of neutrophils from the bone marrow ( 8 ). (diabetesjournals.org)
  • Granulocyte colony-stimulating factor (G-CSF) is a naturally occurring glycoprotein that is synthesized by stromal cells in bone marrow. (springer.com)
  • It is a glycoprotein, growth factor or cytokine produced by a number of different tissues to stimulate the bone marrow to produce granulocytes and stem cells . (wikidoc.org)
  • G-CSF then stimulates the bone marrow to pulse them out of the marrow into the blood. (wikidoc.org)
  • Granulocyte colony-stimulating factor (G-CSF) is a glycoprotein first recognized for its ability to facilitate the formation of neutrophilic granulocyte colonies in soft agar from bone marrow cells [1, 2]. (thefreedictionary.com)
  • Comparison of granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood progenitor cells and G-CSF - stimulated bone marrow as a source of stem cells in HLA-matched sibling transplantation. (thefreedictionary.com)
  • Colony-stimulating factor levels were measured by a semi-solid tissue culture colony assay with murine bone marrow as the target cell source. (ajtmh.org)
  • The role of the sensitivity of bone marrow cells to, and the pharmacokinetics of granulocyte colony-stimulating factor (G-CSF) on the rhythm of leukocyte-increasing effect was investigated in ICR male mice housed under a standardized light-dark cycle (lights on at 0700, off at 1900). (aspetjournals.org)
  • 01). Bone marrow cultures obtained at two times of day resulted in different numbers of myeloid colonies even when treated with the same concentrations of G-CSF in vitro . (aspetjournals.org)
  • Highlighted are the topics of its real or anticipated use in radiation accident victims, the timing of its administration, the possibilities of combining G-CSF with other drugs, the ability of other agents to stimulate endogenous G-CSF production, as well as of the capability of this growth factor to ameliorate not only the bone marrow radiation syndrome but also the gastrointestinal radiation syndrome. (mdpi.com)
  • In this multicenter retrospective study, the outcomes of 234 patients with myelodysplastic syndrome (MDS) who underwent transplantation between 1995 and 1999 from HLA-identical siblings were analyzed according to the hematopoietic stem cell source used, that is, bone marrow (BM, n = 132) or granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells (PBPCs, n = 102). (bloodjournal.org)
  • In chronic myeloid and acute leukemia, the use of granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood progenitor cells (PBPCs) has been associated with faster hematopoietic recovery when compared with bone marrow. (bloodjournal.org)
  • Granulocyte-colony stimulating factor (G-CSF) increases the release of neutrophil endothelial progenitor cells from the bone marrow and improves neutrophil functions, which are often impaired in people with diabetes. (cochrane.org)
  • In nonneutropenic patients, G-CSF may stimulate neutrophil production, enhancing the inflammatory response ( 16 , 17 ). (diabetesjournals.org)
  • Neutrophil migration inhibition factor from T lymphocytes (NIF-T) is a lymphokine that acts to localize granulocytes. (sciencemag.org)
  • In human clinical trials, granulocyte colony-stimulating factor improves neutrophil counts and function, reduces episodes of febrile neutropenia, improves neutrophil recovery after disease- or treatment-induced myelosuppression, and reduces the number of serious infections in several neutropenic disease states. (hindawi.com)
  • In this setting, time to neutrophil recovery is shortened by growth factor administration. (nature.com)
  • Early treatment of neutropenia with granulocyte colony-stimulating factor might play an important role in the rapid increase of neutrophil count with no changes in short term mortality. (thefreedictionary.com)
  • In a Groupe d'Etude et de Traitement de la Leucemie Aigue Lymphoblastique de l'Adulte (GET-LALA) study, in patients who received G-CSF, GM-CSF, or no growth factor during induction therapy, the median time for neutrophil recovery was 17 days for G-CSF, 18 days for GM-CSF, and 21 days for no growth factors. (medscape.com)
  • To study a possible role of neutrophils in granulocyte colony-stimulating factor (G-CSF) induced hematopoietic mobilization, we assessed the number of circulating CD34(+) cells in healthy allogeneic stem cell donors on days 3, 4, and 5 of mobilization for comparison with the number of peripheral blood neutrophils and the plasma levels of IL-8, Flt3 ligand (FL), matrix metalloproteinase-9 (MMP-9), and human neutrophil elastase (HNE). (rug.nl)
  • However, because stem cell numbers could not be predicted by proteolytic enzyme levels and/or neutrophil numbers, other undefined factors may be more important. (rug.nl)
  • Elevated CSF1 levels were identified as a causal risk factor for Coronary Artery Disease with consistent epidemiological results. (nih.gov)
  • Granulocyte Colony-Stimulating Factor ( G-CSF or GCSF ) is a colony-stimulating factor hormone. (wikidoc.org)
  • In recent years some studies have stated that intrauterine infusion of granulocyte colony-stimulating factor (GCSF) may be effective in patients with treatment-resistant thin endometrium. (thefreedictionary.com)
  • Most of these factors are now available as recombinant human colony-stimulating factors, and preclinical and clinical testing is proceeding rapidly. (hindawi.com)
  • Neuroprotective effect of recombinant human granulocyte colony-stimulating factor in transient focal ischemia of mice. (thefreedictionary.com)
  • A glycosylated recombinant human granulocyte colony stimulating factor" by Roslyn Varki, Ed Pequignot et al. (jefferson.edu)
  • A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study. (jefferson.edu)
  • BACKGROUND: AVI-014 is an egg white-derived, recombinant, human granulocyte colony-stimulating factor (G-CSF). (jefferson.edu)
  • Interleukin -3 (IL-3) is sometimes called the 'multi-CSF' because it stimulates the production of all types of lymphocytes and also erythrocytes. (encyclopedia.com)
  • Growth factors which have been studied both in the laboratory and in clinical trials include GM-CSF, granulocyte-colony stimulating factor (G-CSF), and interleukin-3 (IL-3). (nature.com)
  • Plasma levels of stromal cell derived factor 1, angiopoietin 1, interleukin 8 and tumour necrosis factor α decreased after a symptom limited EST while vascular endothelial growth factor and platelet derived growth factor remained unchanged. (bmj.com)
  • Sheridan JW, Metcalf D. A low molecular weight factor in lung-conditioned medium stimulating granulocyte and monocyte colony formation in vitro. (springer.com)
  • We first examined the ability of normal microglia from C57Bl/6J mice to stimulate GL261 glioblastoma cell invasion in vitro. (sigmaaldrich.com)
  • We found that microglia stimulate the invasion of GL261 glioblastoma cells by approximately eightfold in an in vitro invasion assay. (sigmaaldrich.com)
  • Functionally, it is a cytokine and hormone , a type of colony-stimulating factor , and is produced by a number of different tissues . (wikipedia.org)
  • Granulocyte colony-stimulating factor (G-CSF) is a member of the cytokine family of growth factors. (cmaj.ca)
  • On the other hand, GM-CSF deficiency leads to various immune dysfunctions and the current utilization of GM-CSF as haematopoietic factor might be an accurate but very incomplete indication for a cytokine with vast clinical potential. (springer.com)
  • Granulocyte colony-stimulating factor (G-CSF) is a principle cytokine controlling granulocyte number. (springer.com)
  • We have recently identified granulocyte-colony stimulating factor (G-CSF) as a soluble cytokine that alters the behavioral response to cocaine and which increases dopamine release from the ventral tegmental area (VTA). (mdpi.com)
  • Granulocyte colony-stimulating factor (G-CSF), a 20-kDa protein, is a member of the cytokine family of growth factors, along with tumor necrosis factor-α (TNF-α) and the interleukins. (ahajournals.org)
  • Therefore, monocytic and T cell function such as mHLA-DR, tumor necrosis factor alpha (TNF-α) after LPS stimulation, T cell counts, Th1/Th2 specific cytokine production and the ratio of the number of Th17 cells to the number of Treg cells were studied after postoperative GM-CSF application. (medsci.org)
  • A recent abstract presented at the American Society of Clinical Oncology (ASCO) annual meeting compared 2 risk models for patients with intermediate chemotherapy-induced neutropenia (CIN) risk and compared them to guidelines from ASCO and the National Comprehensive Cancer Network to determine when colony-stimulating factor should be ideally used to prevent CIN. (ajmc.com)
  • Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients. (ebscohost.com)
  • Thus a human lymphokine (NIF-T) that modulates the activities of mature neutrophilic granulocytes is also a colony-stimulating factor acting on precursors to induce growth and differentiation of new effector cells. (sciencemag.org)
  • G-CSF stimulates the production of granulocytes , a type of white blood cell. (wikipedia.org)
  • Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor. (wikidoc.org)
  • Consequently, we discuss the pharmacological use of granulopoiesis stimulating factors not only in the context of febrile neutropenia but also from the perspective of MDSC-dependent and MDSC-independent mechanisms of immunosuppression and cancer angiogenesis. (springer.com)
  • Both guidelines from NCCN and ASCO recommend using colony-stimulating factors (CSF) for patients with lung cancer whose chemotherapy regimen carries greater than a 20% risk of developing febrile neutropenia. (ajmc.com)
  • Asano S, Urabe A, Okabe T et al (1977) Demonstration of granulopoietic factor(s) in the plasma of nude mice transplanted with a human lung cancer and in the tumor tissue. (springer.com)
  • Myeloid-derived suppressor cells (MDSCs) have been shown to contribute to tumor escape from host immune surveillance and to cancer progression by production of tumor-promoting soluble factors. (springer.com)
  • Overexpression of an activated mutant of hck in BAC1.2F5 cells augments tumor necrosis factor (TNF) production in response to LPS, whereas inhibition of endogenous hck expression, by antisense oligonucleotides, interferes with LPS-mediated TNF synthesis. (psu.edu)
  • Therefore, it was possible to add various substances to cultures of hemopoietic stem cells and then examine which kinds of colonies (if any) were "stimulated" by them. (wikipedia.org)
  • It is thought that stability of the G-CSF mRNA is regulated by an RNA element called the G-CSF factor stem-loop destabilising element . (wikipedia.org)
  • Because granulocyte colony-stimulating factor (G-CSF) has anti-inflammatory and neuroprotective properties and is known to mobilize stem cells, it may be useful in the treatment of acute ischemic stroke. (cmaj.ca)
  • Hemopoietic stem cells were cultured (see cell culture ) on a so-called semi solid matrix which prevents cells from moving around, so that if a single cell starts proliferating, all of the cells derived from it will remain clustered around the spot in the matrix where the first cell was originally located, and these are referred to as "colonies. (wikidoc.org)
  • Granulocyte colony-stimulating factor with or without stem cell factor extends time to premature ovarian insufficiency in female mice treated with alkylating chemotherapy. (thefreedictionary.com)
  • Recently biosimilars of granulocyte-colony-stimulating factor (G-CSF) became available for prophylaxis and treatment of postchemotherapy neutropenia and for mobilization of peripheral blood CD34+ cells for either autologous or allogeneic hematopoietic stem cell transplant. (wiley.com)
  • The protein functions as a white blood cell growth factor, stimulating stem cells to produce granulocytes and monocytes. (cags.org.ae)
  • Granulocyte colony-stimulating factor exacerbates hematopoietic stem cell injury after irradiation. (stembook.org)
  • The response to granulocyte-colony stimulating factor mobilization was investigated in a murine WAS knock-out model of the disease, by measuring haematological parameters, circulation and engraftment of hematopoietic progenitor/stem cells. (haematologica.org)
  • In spite of these anomalies, the administration of granulocyte-colony stimulating factor mobilizes progenitor/stem cells in WAS knock-out mice to the same level and with the same kinetic as in wild-type control mice. (haematologica.org)
  • The use of growth factors to drive malignant cells into cell cycle and increase sensitivity to chemotherapy has been attempted in a variety of settings. (nature.com)
  • 2, 3 ] Collection may be achieved by using the administration of granulocyte-colony stimulating factor (G-CSF), with or without chemotherapy. (wiley.com)
  • GL261 cells were found to constitutively secrete CSF-1, the levels of which were unaffected by epidermal growth factor (EGF) stimulation, EGFR inhibition or coculture with microglia. (sigmaaldrich.com)
  • This research report will present a complete account of the Global granulocyte colony stimulating factor sales market report 2017 is the ideal amalgamation of documented market information, expert knowledge sets, demonstrated research procedures, and the aim of furnishing its readers with a bare all assessment of the market's development prospects for the coming years. (qyresearchreports.com)
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  • What are the benefits of early use of granulocyte colony-stimulating factor (G-CSF) in the treatment of acute lymphoblastic leukemia (ALL)? (medscape.com)
  • This article concisely summarizes data on the action of one of the principal and best known growth factors, the granulocyte colony-stimulating factor (G-CSF), in a mammalian organism exposed to radiation doses inducing acute radiation syndrome. (mdpi.com)
  • Granulocyte colony-stimulating factor (G-CSF) increases the number of circulating granulocytes and decreases TNF production while improving survival in sepsis models. (nih.gov)
  • Univariate and logistic regression analysis of risk factors for sepsis and rejection revealed no difference between the two patient groups. (nih.gov)
  • We performed a randomized, double-masked, parallel-groups, placebo-controlled trial of recombinant granulocyte colony-stimulating factor (rG-CSF) administration to 44 preterm neonates who had blood cultures obtained and antibiotics begun because of the clinical diagnosis of early-onset sepsis. (aappublications.org)
  • Five-day prophylactic GM-CSF completely abolishes postnatal neutropenia and sepsis-induced neutropenia in preterm neonates at high risk of sepsis, and so removes an important risk factor for sepsis and sepsis-related mortality.GM-CSF, preterm neonates, neutropenia, sepsis. (aappublications.org)
  • 1 Attempts to prevent sepsis or reduce sepsis-related mortality using intravenous immunoglobulin have failed to make a major impact 2 and attention has recently turned to the potential enhancement of phagocyte immunity using the hemopoietic colony-stimulating factors. (aappublications.org)
  • Burgess AW, Camakaris J, Metcalf D. Purification and properties of colony-stimulating factor from mouse lung-conditioned medium. (springer.com)
  • Purification and some properties of the colony stimulating factor from medium conditioned by mouse L cells. (psu.edu)
  • Purification and characterization of human granulocyte colony-stimulating factor (G-CSF). (nii.ac.jp)
  • Phagocytosis, H2O2 production, Mac-1 expression, and in vivo elimination of Listeria monocytogenes were enhanced in granulocyte colony-stimulating factor (G-CSF)-treated mice. (asm.org)
  • Molgradex offers a novel treatment approach for NTM infection by stimulating the human immune system in the lungs with localized delivery of GM-CSF, directly into the site of infection. (benzinga.com)
  • A recent study of our research group aimed to stimulate postoperative immune function using GM-CSF and found an increase of mHLA-DR as well as a decrease of infection days after application of GM-CSF [ 5 ]. (medsci.org)
  • To examine the effects of adjunctive G-CSF compared with placebo or no growth factor added to usual care on rates of infection, cure and wound healing in people with diabetes who have a foot infection. (cochrane.org)
  • Studies have been done to determine the levels of human urinary granulocyte colony-stimulating factor in Egyptian patients with active bilharziasis. (ajtmh.org)
  • Objectives: Granulocyte-colony stimulating factor (G-CSF) is known to induce the myeloid-derived suppressor cell (MDSC) to stimulate the progression of uterine cervical cancer. (aacrjournals.org)
  • Dendritic cells (DCs) have a unique ability to stimulate naive T cells. (jimmunol.org)
  • Granulocyte-colony stimulating factor (G-CSF) is type of drug called a growth factor. (macmillan.org.uk)
  • G-CSF stimulates the growth and improves the function of both normal and defective neutrophils ( 9 ), including in patients with diabetes ( 10 ). (diabetesjournals.org)
  • Growth Factors. (springer.com)
  • angiogenesis factor a substance that causes the growth of new blood vessels, found in tissues with high metabolic requirements such as cancers and the retina. (thefreedictionary.com)
  • 1). These interactions are important for a variety of reasons, such as localizing cells within the microenvironment, directing cellular migration, and initiating growth factor-mediated developmental programs. (taylorfrancis.com)
  • However, simple interactions, such as those between cells and growth factors, are not the only interactions by which developing cells are regulated. (taylorfrancis.com)
  • Further complexity occurs through interactions of cells and growth factors with the extracellular matrix, or by combined interactions that generate a specific developmental responses. (taylorfrancis.com)
  • The mRNA levels of genes related to ECM components and ECM production-related growth factors, such as HGF and TGF-ß1, were examined by real time RT-PCR. (sigmaaldrich.com)
  • 4-6 After binding to high-affinity membrane receptors, the effects of growth factors are mediated by the activation of a series of kinases that translocate to the nucleus to phosphorylate transcription factors. (ahajournals.org)
  • This could be of interest, because G-CSF is one of the few growth factors approved for clinical use. (ahajournals.org)
  • The Midwest with sales (volume), revenue (value), market share and growth rate of Granulocyte-Colony Stimulating Factor in these regions, from 2012 to 2022 (forecast). (qyresearchreports.com)
  • Colony-stimulating factors in inflammation and autoimmunity. (springer.com)