Colonic Neoplasms: Tumors or cancer of the COLON.Dimethylhydrazines: Hydrazines substituted with two methyl groups in any position.Intestinal Polyps: Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.Adenoma: A benign epithelial tumor with a glandular organization.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Colonic Diseases: Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Pancreatic Neoplasms: Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).Colonic Polyps: Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.Neoplasms, Cystic, Mucinous, and Serous: Neoplasms containing cyst-like formations or producing mucin or serum.Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Skin Neoplasms: Tumors or cancer of the SKIN.Gastrointestinal Transit: Passage of food (sometimes in the form of a test meal) through the gastrointestinal tract as measured in minutes or hours. The rate of passage through the intestine is an indicator of small bowel function.Colonic Pseudo-Obstruction: Functional obstruction of the COLON leading to MEGACOLON in the absence of obvious COLONIC DISEASES or mechanical obstruction. When this condition is acquired, acute, and coexisting with another medical condition (trauma, surgery, serious injuries or illness, or medication), it is called Ogilvie's syndrome.Diverticulosis, Colonic: A pathological condition characterized by the presence of a number of COLONIC DIVERTICULA in the COLON. Its pathogenesis is multifactorial, including colon aging, motor dysfunction, increases in intraluminal pressure, and lack of dietary fibers.Kidney Neoplasms: Tumors or cancers of the KIDNEY.Gastrointestinal Motility: The motor activity of the GASTROINTESTINAL TRACT.Neoplasms, Second Primary: Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.Adenocarcinoma, Mucinous: An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.ArchivesColorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.Polyps: Discrete abnormal tissue masses that protrude into the lumen of the DIGESTIVE TRACT or the RESPIRATORY TRACT. Polyps can be spheroidal, hemispheroidal, or irregular mound-shaped structures attached to the MUCOUS MEMBRANE of the lumen wall either by a stalk, pedunculus, or by a broad base.Azoxymethane: A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Nitrosomethylurethane: An alkylating carcinogen that produces gastrointestinal and probably lung and nervous system tumors.Dextran Sulfate: Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.Laparoscopy: A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.Polydioxanone: An absorbable suture material used also as ligating clips, as pins for internal fixation of broken bones, and as ligament reinforcement for surgically managed ligament injuries. Its promising characteristics are elasticity, complete biodegradability, and lack of side effects such as infections.Cholecystectomy, Laparoscopic: Excision of the gallbladder through an abdominal incision using a laparoscope.Colectomy: Excision of a portion of the colon or of the whole colon. (Dorland, 28th ed)Physical Therapy Modalities: Therapeutic modalities frequently used in PHYSICAL THERAPY SPECIALTY by PHYSICAL THERAPISTS or physiotherapists to promote, maintain, or restore the physical and physiological well-being of an individual.Body Composition: The relative amounts of various components in the body, such as percentage of body fat.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Platelet Activating Factor: A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Sentinel Lymph Node Biopsy: A diagnostic procedure used to determine whether LYMPHATIC METASTASIS has occurred. The sentinel lymph node is the first lymph node to receive drainage from a neoplasm.Lymph Nodes: They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.Rosaniline Dyes: Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta color and are used as COLORING AGENTS.Spectroscopy, Near-Infrared: A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.Indocyanine Green: A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.Lymphatic Metastasis: Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.Technetium Tc 99m Sulfur Colloid: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, liver, and spleen.Lymphomatoid Granulomatosis: An angiocentric and angiodestructive lymphoproliferative disorder primarily involving the lungs. It is caused by an Epstein-Barr virus-induced transformation of the B-cells, in a T-cell rich environment. Clinically and pathologically it resembles EXTRANODAL NK-T-CELL LYMPHOMA.Lymphoma, B-Cell, Marginal Zone: Extranodal lymphoma of lymphoid tissue associated with mucosa that is in contact with exogenous antigens. Many of the sites of these lymphomas, such as the stomach, salivary gland, and thyroid, are normally devoid of lymphoid tissue. They acquire mucosa-associated lymphoid tissue (MALT) type as a result of an immunologically mediated disorder.Lymphoma, B-Cell: A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes.Lymphoma: A general term for various neoplastic diseases of the lymphoid tissue.Lymphoma, Non-Hodgkin: Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.Lymphoma, T-Cell: A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.Lymphoma, Extranodal NK-T-Cell: An extranodal neoplasm, usually possessing an NK-cell phenotype and associated with EPSTEIN-BARR VIRUS. These lymphomas exhibit a broad morphologic spectrum, frequent necrosis, angioinvasion, and most commonly present in the midfacial region, but also in other extranodal sites.

Classification of human colorectal adenocarcinoma cell lines. (1/11349)

Eleven human colorectal adenocarcinoma cell lines established in this laboratory were classified into three groups based on morphological features (light and electron microscopy), modal chromosome number, and ability to synthesize carcinoembryonic antigen (CEA). Group 1 cell lines contained both dedifferentiated and differentiating cells growing in tight clusters or islands of epithelium-like cells; their modal chromosome number was about 47, and they synthesized small to moderate amounts of CEA. Group 2 cell lines were more dedifferentiated, were hyperdiploid, and synthesized small amounts of CEA. Group 3 cell lines were morphologically similar to those of Group 1 by light microscopy. They differed ultrastructurally by containing microvesicular bodies; the modal chromosome number varied from hyperdiploid to hypertriploid or they had bimodal populations of hypodiploid and hypertriploid cells, and they synthesized relatively large amounts of CEA. No correlation could be found between Broder's grade or Duke's classification of the original tumor and modal chromosome number or ability to synthesize CEA. These findings support Nowell's hypothesis that the stem line is different for each solid tumor, which makes it difficult to relate chromosomal changes to the initiation of the neoplastic state.  (+info)

PKCdelta acts as a growth and tumor suppressor in rat colonic epithelial cells. (2/11349)

We have analysed the expression of three calcium-independent isoforms of protein kinase C (PKC), PKCdelta, PKCepsilon and PKCzeta, in an in vitro model of colon carcinogenesis consisting of the nontumorigenic rat colonic epithelial cell line D/WT, and a derivative src-transformed line D/src. While PKCzeta and PKCepsilon showed similar protein levels, PKCdelta was markedly decreased in D/src cells when compared to the D/WT line. To assess whether down-regulation of PKCdelta was causally involved in the neoplastic phenotype in D/src cells, we prepared a kinase-defective mutant of PKCdelta. Stable transfection of this sequence caused morphological and growth changes characteristic of partial transformation in D/WT cells. Moreover, to test whether PKCdelta was involved in growth control and transformation in this model, we overexpressed PKCdelta in D/src cells. Transfected cells underwent marked growth and morphological modifications toward the D/WT phenotype. In a late stage in culture, transfected cells ceased to proliferate, rounded up and degenerated into multinucleated, giant-like cells. We conclude that PKCdelta can reverse the transformed phenotype and act as a suppressor of cell growth in D/src cells. Moreover, our data show that downregulation of this isoenzyme of PKC may cooperate in the neoplastic transformation induced by the src oncogene in D/WT cells.  (+info)

The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells. (3/11349)

The acquisition of invasiveness is a crucial step in the malignant progression of cancer. In cancers of the colon and of other organs the E-cadherin/catenin complex, which is implicated in homotypic cell-cell adhesion as well as in signal transduction, serves as a powerful inhibitor of invasion. We show here that one allele of the alphaE-catenin (CTNNA1) gene is mutated in the human colon cancer cell family HCT-8, which is identical to HCT-15, DLD-1 and HRT-18. Genetic instability, due to mutations in the HMSH6 (also called GTBP) mismatch repair gene, results in the spontaneous occurrence of invasive variants, all carrying either a mutation or exon skipping in the second alphaE-catenin allele. The alphaE-catenin gene is therefore, an invasion-suppressor gene in accordance with the two-hit model of Knudsen for tumour-suppressor genes.  (+info)

Mechanisms related to [18F]fluorodeoxyglucose uptake of human colon cancers transplanted in nude mice. (4/11349)

[18F]Fluorodeoxyglucose ([18F]FDG), a glucose analogue, has been widely used for tumor imaging. To investigate the mechanisms related to [18F]FDG uptake by tumors, an experiment involving nude mice was performed. METHODS: Human colon cancer cell lines SNU-C2A, SNU-C4 and SNU-C5 were transplanted to nude mice. Using immunohistochemical staining and Western blot, the expression of glucose transporter (Glut) isoforms (Glut-1 through -5) in xenografted tumors was analyzed. For the analysis of messenger ribonucleic acid (mRNA) expression, reverse-transcription polymerase chain reaction and Northern blot were used and the enzyme activity of hexokinase in cancer tissues was measured by continuous spectrophotometric rate determination. RESULTS: [18F]FDG uptake in SNU-C4 and SNU-C5 cells was higher than in normal colon cells. Among these cells and xenografted tumors, SNU-C5 showed the highest level of [18F]FDG uptake, followed by SNU-C4 and SNU-C2A. An immunostaining experiment showed intense staining of Glut-1 in SNU-C5 tumors but somewhat faint staining in SNU-C4. SNU-C5 tumors also showed positive staining with Glut-3, although this was not the case with SNU-C2A and SNU-C4. Western blot analysis showed the expression of Glut-1 and Glut-3 in all tumors. Experiments involving Northern blot analysis and reverse-transcription polymerase chain reaction confirmed the overexpression of Glut-1 mRNA in all tumors, with the highest level in SNU-C5. The level of Glut-3 mRNA was also elevated in SNU-C5 tumors but not in SNU-C2A and SNU-C4. The enzyme activity of hexokinase did not vary among different tumors. CONCLUSION: Gluts, especially Glut-1, are responsible for [18F]FDG uptake in a nude mouse model of colon cancer rather than hexokinase activity. Increased numbers of glucose transporters at the plasma membrane of cancer cells is attributed to an increased level of transcripts of glucose transporter genes and may be a cause of increased [18F]FDG uptake, at least in colon cancer tumors.  (+info)

In vivo isolated kidney perfusion with tumour necrosis factor alpha (TNF-alpha) in tumour-bearing rats. (5/11349)

Isolated perfusion of the extremities with high-dose tumour necrosis factor alpha (TNF-alpha) plus melphalan leads to dramatic tumour response in patients with irresectable soft tissue sarcoma or multiple melanoma in transit metastases. We developed in vivo isolated organ perfusion models to determine whether similar tumour responses in solid organ tumours can be obtained with this regimen. Here, we describe the technique of isolated kidney perfusion. We studied the feasibility of a perfusion with TNF-alpha and assessed its anti-tumour effects in tumour models differing in tumour vasculature. The maximal tolerated dose (MTD) proved to be only 1 microg TNF-alpha. Higher doses appeared to induce renal failure and a secondary cytokine release with fatal respiratory and septic shock-like symptoms. In vitro, the combination of TNF-alpha and melphalan did not result in a synergistic growth-inhibiting effect on CC 531 colon adenocarcinoma cells, whereas an additive effect was observed on osteosarcoma ROS-1 cells. In vivo isolated kidney perfusion, with TNF-alpha alone or in combination with melphalan, did not result in a significant anti-tumour response in either tumour model in a subrenal capsule assay. We conclude that, because of the susceptibility of the kidney to perfusion with TNF-alpha, the minimal threshold concentration of TNF-alpha to exert its anti-tumour effects was not reached. The applicability of TNF-alpha in isolated kidney perfusion for human tumours seems, therefore, questionable.  (+info)

Cancer risk in close relatives of women with early-onset breast cancer--a population-based incidence study. (6/11349)

Inherited susceptibility to breast cancer is associated with an early onset and bilateral disease. The extent of familial risks has not, however, been fully assessed in population-based incidence studies. The purpose of the study was to quantify the risks for cancers of the breast, ovary and other sites of close relatives of women in whom breast cancer was diagnosed at an early age. Records collected between 1943 and 1990 at the Danish Cancer Registry were searched, and 2860 women were found in whom breast cancer was diagnosed before age 40. Population registers and parish records were used to identify 14 973 parents, siblings and offspring of these women. Cancer occurrence through to 31 December 1993 was determined within the Cancer Registry's files and compared with national incidence rates. Women with early-onset breast cancer were at a nearly fourfold increased risk of developing a new cancer later in life (268 observed vs. 68.9 expected). The excess risk was most evident for second cancer of the breast (181 vs. 24.5) and for ovarian cancer (20 vs. 3.3). For mothers and sisters, risks for cancers of the breast and ovary were significantly increased by two- to threefold. Bilateral breast cancer and breast-ovarian cancer were very strong predictors of familial risks, with one in four female relatives predicted to develop breast and/or ovarian cancer by age 75. Mothers had a slightly increased risk of colon cancer, but not endometrial cancer. The risk for breast cancer was also increased among fathers (standardized incidence ratio 2.5; 95% CI 0.5-7.4) and especially brothers (29; 7.7-74), although based on small numbers. The risk for prostatic cancer was unremarkable. In this large population-based survey, the first-degree relatives of women who developed breast cancer before age 40 were prone to ovarian cancer as well as male and female breast cancer, but not other tumours that may share susceptibility genes with breast cancer.  (+info)

Bombesin stimulates adhesion, spreading, lamellipodia formation, and proliferation in the human colon carcinoma Isreco1 cell line. (7/11349)

The neuropeptide bombesin and its mammalian homologue, gastrin-releasing peptide (GRP), enhance proliferation in some but not all human tumor cell lines. The pathophysiological relevance of the bombesin/GRP receptor (GRP-R), which is expressed in 30% of human colon tumor cell lines and in 24-40% of native tumors, has not been clearly assessed at this time. We studied the effects of bombesin in the recently characterized human colon carcinoma Isreco1 cell line. Competitive reverse transcription-PCR showed a high GRP-R mRNA level in Isreco1 cells, and binding studies confirmed the expression of bombesin/GRP-subtype receptors (Kd = 0.42 nM; Bmax = 18,000 sites/cell). Exposure to bombesin resulted in an increase of intracellular calcium concentrations. Bombesin (1 nM) induced cell spreading at 24 h (21.7+/-1.6% versus 6.4+/-0.8% in control cells; P<0.01) and markedly increased the formation of lamellipodia. In addition, adhesion of Isreco1 cells to collagen I-coated culture dishes was stimulated in the presence of 1 nM bombesin (69+/-6% versus 42+/-1% in control cells; P<0.01). Finally, bombesin significantly increased [3H]thymidine uptake by Isreco1 cells in a dose-dependent manner, with a first significant response at 0.1 nM and a maximal effect at 100 nM bombesin (192.2+/-9.7% of control). These results clearly indicate that bombesin exerts morphological, adhesive, and proliferative effects on Isreco1 cells, suggesting that expression of the bombesin/GRP-R may contribute to the malignant properties of colon carcinoma cells.  (+info)

Telomeric repeats on small polydisperse circular DNA (spcDNA) and genomic instability. (8/11349)

Small polydisperse circular DNA (spcDNA) is a heterogeneous population of extrachromosomal circular molecules present in a large variety of eukaryotic cells. Elevated amounts of total spcDNA are related to endogenous and induced genomic instability in rodent and human cells. We suggested spcDNA as a novel marker for genomic instability, and speculated that spcDNA might serve as a mutator. In this study, we examine the presence of telomeric sequences on spcDNA. We report for the first time the appearance of telomeric repeats in spcDNA molecules (tel-spcDNA) in rodent and human cells. Restriction enzyme analysis indicates that tel-spcDNA molecules harbor mostly, if not exclusively, telomeric repeats. In rodent cells, tel-spcDNA levels are higher in transformed than in normal cells and are enhanced by treatment with carcinogen. Tel-spcDNA is also detected in some human tumors and cell lines, but not in others. We suggest, that its levels in human cells may be primarily related to the amount of the chromosomal telomeric sequences. Tel-spcDNA may serve as a unique mutator, through specific mechanisms related to the telomeric repeats, which distinguish it from the total heterogeneous spcDNA population. It may affect telomere dynamics and genomic instability by clastogenic events, alterations of telomere size and sequestration of telomeric proteins.  (+info)

In patients with locally advanced colon cancer (high risk stage II and stage III), curative surgery followed by adjuvant FOLFOX-4 chemotherapy has become the standard of care. However, for 30-40% of these patients, the current curative treatment strategy of surgical excision followed by adjuvant chemotherapy fails either to clear locoregional spread or to eradicate distant micrometastases, leading to disease recurrence. Preoperative chemotherapy is an attractive concept for locally advanced colon cancer and has the potential to impact upon both of these causes of failure. Optimum systemic therapy at the earliest possible opportunity may be more effective at eradicating distant metastases than the same treatment given after the delay and immunological stress of surgery. Added to this, shrinking the primary tumor before surgery may reduce the risk of incomplete surgical excision, and the risk of tumor cell shedding during surgery.. ECKINOXE is a multicenter randomized phase II trial designed to ...
In patients with locally advanced colon cancer (high risk stage II and stage III), curative surgery followed by adjuvant FOLFOX-4 chemotherapy has become the standard of care. However, for 30-40% of these patients, the current curative treatment strategy of surgical excision followed by adjuvant chemotherapy fails either to clear locoregional spread or to eradicate distant micrometastases, leading to disease recurrence. Preoperative chemotherapy is an attractive concept for locally advanced colon cancer and has the potential to impact upon both of these causes of failure. Optimum systemic therapy at the earliest possible opportunity may be more effective at eradicating distant metastases than the same treatment given after the delay and immunological stress of surgery. Added to this, shrinking the primary tumor before surgery may reduce the risk of incomplete surgical excision, and the risk of tumor cell shedding during surgery.. ECKINOXE is a multicenter randomized phase II trial designed to ...
Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis.: Patients with mucinou
BioAssay record AID 86084 submitted by ChEMBL: In vitro cytotoxicity against human colon adenocarcinoma cell line HT-29 at 5.9*10e-5M.
Berberine reduces cAMP-induced chloride secretion in T84 human colonic carcinoma cells through inhibition of basolateral KCNQ1 channels
The American Cancer Society and the Cigna Foundation have awarded $232,000 to MedStar Washington Hospital Center to address advanced colon cancer.
Genes May Determine Aspirins Effect on Advanced Colon Cancer, Harvard School of Public Health Study - read this article along with other careers information, tips and advice on BioSpace
This page provides useful content and local businesses that can help with your search for Colon Cancer Treatment. You will find helpful, informative articles about Colon Cancer Treatment, including Colon Cancer. You will also find local businesses that provide the products or services that you are looking for. Please scroll down to find the local resources in Lakeville, MN that will answer all of your questions about Colon Cancer Treatment.
This page provides useful content and local businesses that can help with your search for Colon Cancer Treatment. You will find helpful, informative articles about Colon Cancer Treatment, including Colon Cancer. You will also find local businesses that provide the products or services that you are looking for. Please scroll down to find the local resources in Carson City, NV that will answer all of your questions about Colon Cancer Treatment.
Colon Cancer Treatment cost in India starts from USD 7000. Find affordable packages, best specialists, hospitals and patient experiences for Colon Cancer Treatment in India through Vaidam.
We believe this is the first case report of anunusual presentation of hypercalcemia due to sarcoidosis mimicking metastatic colon carcinoma. A 68 year old lady with a background history of pancolectomy and neoadjuvant chemotherapy for Duke C1 rectal carcinoma under surveillance, ulcerative colitis, type 2 diabetes mellitus presented to the clinic with hypercalcemia with low parathyroid hormone (PTH) and symptoms of tiredness. Her blood test showed Adj Ca of 2.8 mmol/l, PTH , 2.5 pmol/l, Vitamin D 18 mol/l, ALP 177 U/l. She was commenced on 800 IU of vitamin D, ordered for bone scan, 24 h urine calcium excretion ratio, myeloma screen. Her surveillance CT scan couple of months earlier was reported stable features. She had an acute medical admission with unsteadiness of gait, tiredness and nausea. The adjusted calcium level was reported as 3.6 mmol/l with suppressed PTH. She was resuscitated with intravenous fluids and bisphosphate infusion. A CT scan of abdomen, chest and pelvis was organised that ...
A patient with a metastatic colon carcinoma was treated by immunoadsorption (IA) therapy using heat-killed, formalin-stabilized protein A-containing Staphylococcus aureus Cowan I as the immunoadsorbent. The patient experienced both subjective and objective positive clinical response without undue morbidity. The patients response correlated well with laboratory findings of decreased concentrations of carcinoembryonic antigen (CEA), immunoglobulin G (IgG), immune complexes (IC) and histopathologic data. The patient underwent surgery following 15 IA treatments; she lived for eighteen months, post-treatment.
Colon cancer is one of the most frequent solid tumor and simultaneous diagnosis of primary colon cancer and liver metastases occurs in about one fourth of cases. The current knowledge on epigenetic signatures, especially those related to hydroxymethylation in primary cancer tissue, synchronous metastasis and blood circulating cells is lacking. This study aimed to investigate both methylcytosine (mCyt) and hydroxymethylcytosine (hmCyt) status in the DNA of individual patients from colon cancer tissue, synchronous liver metastases, and in cancer-free colon and liver tissues and leukocytes. Patients undergoing curative surgery (n=16) were enrolled and their laboratory and clinical history data collected. The contents of mCyt and hmCyt were determined by a liquid chromatography/mass spectrometry (LC/MS/MS) method in DNA extracted from primary colon cancer, synchronous hepatic metastatic tissues and homologous cancer-free tissues, i.e., colon and liver tissues as well as leukocytes. The mCyt and hmCyt
Researchers have identified a biomarker that predicts which stage II colon cancer patients may benefit from adjuvant chemotherapy.
TY - JOUR. T1 - Single-dose versus fractionated radioimmunotherapy of human colon carcinoma xenografts using 131I-labeled multivalent CC49 single-chain Fvs1. AU - Goel, A.. AU - Augustine, S.. AU - Baranowska-Kortylewicz, Janina. AU - Colcher, D.. AU - Booth, B. J M. AU - Pavlinkova, G.. AU - Tempero, M.. AU - Batra, Surinder Kumar. PY - 2001/2/12. Y1 - 2001/2/12. N2 - The prospects of radiolabeled antibodies in cancer detection and therapy remain promising. However, efforts to achieve cures, especially of solid tumors, with the systemic administration of radiolabeled monoclonal antibodies (MAbs) have met with limited success. Using genetic engineering techniques, MAbs have been tailored to improve the therapeutic index (tumor:normal tissue ratio) in clinical radioimmunotherapy. In the present study, we investigated the potential of tetravalent {[sc(Fv)2]2} and divalent [sc(FV)2] single chain Fvs of MAb CC49 for therapy in athymic mice bearing s.c. LS-174T human colon carcinoma xenografts. Mice ...
TY - JOUR. T1 - Completion of therapy by medicare patients with stage III colon cancer. AU - Dobie, Sharon A.. AU - Baldwin, Laura Mae. AU - Dominitz, Jason A.. AU - Matthews, Barbara. AU - Billingsley, Kevin. AU - Barlow, William. PY - 2006/5/3. Y1 - 2006/5/3. N2 - Background: Certain factors, such as race or age, are known to be associated with variation in initiation of adjuvant chemotherapy for stage III colon cancer, but little is known about what factors are associated with completion of adjuvant therapy. To determine whether predictors of initiation also predict completion, we analyzed Surveillance, Epidemiology, and End Results (SEER) program data linked to Medicare claims. We investigated mortality as a means to testing the validity of the completion measure that we created. Methods: We studied 3193 stage III colon cancer patients whose diagnosis was recorded in 1992-1996 SEER program data linked to 1991-1998 Medicare claims and who initiated adjuvant chemotherapy after colon cancer ...
Currently, data regarding the prognosis of right-sided versus left-sided colon cancer are conflicting, however, most studies revealed a poorer survival in right-sided primary tumor location [14-18, 29].. To our knowledge this is the first population-based, propensity score adjusted analysis investigating the prognostic impact of tumor location in non-metastatic colon cancer patients. Being aware of the conflicting data and also of the challenges to handle relevant bias due to substantial imbalances regarding baseline characteristics between right- and left-sided colon cancer patients, we have intentionally selected the propensity score matching as a further statistical method in addition to common multivariate analysis to minimize confounding. In the present analysis, the cohort was partitioned into subgroups containing one or more patients with right-sided colon cancer who were matched to one or more patients with left-sided colon cancer with similar values on the observed covariates in the ...
TY - JOUR. T1 - Identification of Endogenous Inhibitory Growth Factors from a Human Colon Carcinoma Cell Line. AU - Levine, Alan E.. AU - McRae, L. J.. AU - Hamilton, David A.. AU - Brattain, Diane E.. AU - Yeoman, Lynn C.. AU - Brattain, Michael G.. PY - 1985/5/1. Y1 - 1985/5/1. N2 - A line of human colon carcinoma cells, designated MOSER, was established which synthesized tumor-inhibitory factor (TIF) and transforming growth factor (TGF) activity. Both activities were found in serum-free conditioned medium and in cell extracts. The activities coelute on Bio-Gel P-10 in acetic acid, but can be completely separated by reverse-phase high-pressure liquid chromatography. The TIF and TGF activities were acid and heat stable and were sensitive to trypsin and dithiothreitol. MOSER cell TIF prevented the anchorage-independent growth of the more differentiated colon carcinoma cell lines tested but did not affect the less differentiated lines. Using anchorage-dependent growth conditions, the effect of ...
2018 American Association for Cancer Research. Unresectable hepatic metastases of colon cancer respond poorly to existing therapies and are a major cause of colon cancer lethality. In this study, we evaluated the therapeutic viability of targeting the mediator kinase CDK8, an early clinical stage drug target, as a means to suppress metastasis of colon cancer. CDK8 was amplified or overexpressed in many colon cancers and CDK8 expression correlated with shorter patient survival. Knockdown or inhibition of CDK8 had little effect on colon cancer cell growth but suppressed metastatic growth of mouse and human colon cancer cells in the liver. This effect was due in part to inhibition of already established hepatic metastases, indicating therapeutic potential of CDK8 inhibitors in the metastatic setting. In contrast, knockdown or inhibition of CDK8 had no significant effect on the growth of tumors implanted subcutaneously, intrasplenically, or orthotopically in the cecum. CDK8 mediated colon cancer ...
BACKGROUND: Circular RNAs (circRNAs) are considered to be highly stable due to the closed structure, which are predominately correlated with the development and progression of a wide variety of cancers. Colon cancer is one of the most common malignancies worldwide. A recent study demonstrated the upregulated expression of circPIP5K1A in non-small cell lung cancer. However, few studies have investigated the relationship between circ_0014130 level and colon cancer. Therefore, elucidating the underlying mechanisms of circPIP5K1As role may help with the identification of novel diagnostic and therapeutic targets for colon cancer. AIM: To investigate the status of circPIP5K1A in colon cancers and its effects on the modulation of cancer development. METHODS: The expression level of circPIP5K1A in tissue and serum samples from colon cancer patients, as well as human colonic cancer cell lines was detected by real-time quantitative reverse transcription-polymerase chain reaction. Following the ...
4334 Vascular endothelial growth factor (VEGF) has been shown to be associated with tumor angiogenesis and poor prognosis in human colon cancer. VEGF receptor-1 (VEGFR-1/Flt-1) is a high-affinity receptor for VEGF and is typically viewed as being endothelial cell specific. Here we report on the expression and function of VEGFR-1 on colon cancer cell lines. VEGFR-1 was expressed in 7/7 colon cancer cell lines as determined by Western blot analysis. Treatment of the human colon cancer cell line SW480 with VEGF-A (ligand for both VEGFR-1 and VEGFR-2) or VEGF-B (a ligand specific for VEGFR-1) led to activation of Erk 1/2. A blocking antibody to VEGFR-1 (18F1) completely inhibited the ability of VEGF-A and -B to activate Erk 1/2 in SW480 cells. VEGF-A and B did not increase colon cancer cell proliferation as determined by the MTT assay. However, VEGF-A and VEGF-B led to a significant induction of cancer cell motility and invasion through Matrigel. VEGF-A and -B stimulation of colon tumor cells also ...
Colon cancer treatments are varied and you can choose from a series of traditional and alternative methods of dealing with this condition. Surgery is often the number one choice - the surgeon removes the tumors on the colon, even if the cancer cells are spread beyond the colon itself. This ensures less problems in the future of the patients life, reducing chances of bowel problems or internal bleeding. Colon cancer surgery is usually categorized in four main areas: rectum resection, radio frequency ablation, colostomy and colon resection. The surgeon will determine which method is best suited for each individual patient ...
ORLANDO-Compared with the standard first-line chemotherapy treatment for advanced colorectal cancer, patients treated with the FOLFOX4 regimen containing the investigational agent oxaliplatin lived longer and had fewer side effects. 1
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
Colon cancer is the second leading cause of cancer death in men and women. New Hope Unlimiteds alternative colon cancer treatment consists of a non-invasive, less toxic and more effective treatment strategy that improves the symptoms and reverse the disease. Know your options and call us at 480-845-0813.
Background Cyclooxygenase-2 (COX-2) is a key factor in the development of colorectal cancer, and non-steroidal anti-inflammatory drugs (NSAIDs) have anti-colorectal cancer activity. However, the potential molecular mechanism of the COX-2 selective inhibitor effect on proliferation and apoptosis of colon cancer cells is unclear. In this study, we have demonstrated for the first time that the Delta1/Notch1 signal transduction pathway mediates the COX-2 selective inhibitor effect on colorectal cancer cells, and we reveal the mechanism of the Notch1 pathway in terms of regulating the proliferation and apoptosis of colorectal cancer cells. Methods and Result Colon cancer cell lines HT-29 and SW480 were treated with NS-398 (a COX-2 selective inhibitor) and DAPT (a gamma-secretase inhibitor). The colormetric MTT cell proliferation assay and flow cytometry were used to measure cell proliferation and apoptosis. Reverse transcriptase (RT)-PCR and ELISA analyses were used to detect the levels of COX-2 mRNA ...
TY - JOUR. T1 - RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells. AU - Subauste, M. Cecilia. AU - Ventura-Holman, T.. AU - Du, L.. AU - Subauste, Jose S.. AU - Chan, Shing Leng. AU - Yu, Victor C.. AU - Maher, Joseph F.. PY - 2009/12/1. Y1 - 2009/12/1. N2 - Evasion of apoptosis plays an important role in colon cancer progression. Following loss of the Apc tumor suppressor gene in mice, the gene encoding Fem1b is upregulated early in neoplastic intestinal epithelium. Fem1b is a pro-apoptotic protein that interacts with Fas, TNFR1 and apaf-1, and increased expression of Fem1b induces apoptosis of cancer cells. Fem1b is a homolog of FeM-1, a protein in Caenorhabditis elegans that is negatively regulated by ubiquitination and proteasomal degradation. To study Fem1b regulation in colon cancer progression, we used apoptotis-sensitive SW480 cells, derived from a primary colon cancer, and their isogenic, apoptosis-resistant counterparts sW620 cells, ...
Learn about Colon Cancer Treatment (Patient). Information from PDQ, the National Cancer Institutes comprehensive cancer information database.
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
Cancer Monthly. Colon Cancer treatments. Chemotherapy. Monash University, Melbourne, Australia. Compare therapy differences, longest survival rates, toxicity, side effects, hospitals.
Cancer Monthly. Colon Cancer treatments. Chemotherapy. Universitat Aut noma de Barcelona, Barcelona, Spain. Compare therapy differences, longest survival rates, toxicity, side effects, hospitals.
It is pertinent however to determine wholesome cooking strategies in addition to consuming habits in methods to not intervene with the nutritious worth of meals Mother Nature intended. Have you ever ever gone through a grueling weight reduction program for a very long time, solely to seek out out later that youve hit a wall when it comes to outcomes. You wont end up tempted almost as much if your forbidden foods arent simply accessible. Correctly, chances are youll need to do additional than merely discovering a meals plan reply program. He did it greater than 50 years earlier. One factor to remember when deciding how one can go about shedding pounds is that there is no such thing as a single greatest way to lose weight. This can be a weight loss program thats loaded with numerous greens and fruits, chemopreventive effects of dietary canola oil on colon cancer development with the lean meats and likewise other protein sources. Due to this actuality, it is best to avoid excessive consumption ...
Among patients with Stage II or Stage III colon cancer, the Oncotype DX colon cancer test provides information about risk of cancer recurrence and may help guide treatment decisions. These results were presented at the 2012 Annual Meeting of the American Society of Clinical Oncology.. Gene expression profiling explores the patterns of genes that are active in tumor cells. Studies suggest that gene expression may provide important information about prognosis or likely response to treatment in several types of cancer. For example, among women with early-stage, estrogen receptor-positive breast cancer, the Oncotype DX breast cancer test has been shown to predict the likelihood of cancer recurrence and the likelihood of benefit from chemotherapy. As a result, the test has been added to medical guidelines for early-stage breast cancer.. A similar test became available for colon cancer patients in 2010. The test was originally developed for use in patients with Stage II colon cancer, but has now also ...
➤ Colon cancer treatment in clinics of Anyang, ➤ 16 clinics, Addresses, $ Prices for treatments and diagnostics, ☺ 43 reviews, ✎ Make an appointment, ✉ 3,439 patients are sent for treatment
Before talking about colon cancer prevention, lets talk a little about what colon cancer is, exactly. Both the colon and rectum are part of the digestive system. The first part of the digestive system, which is the esophagus and stomach, breaks down food to be processed into energy. Next, the broken down food travels to the small intestine/bowel, which is a narrow, 20-foot section that continues breaking down food and absorbing most of the nutrients. The small intestine then sends the remaining material to the five-foot-long colon (which is also referred to as "the large intestine"), where it absorbs salt and water and stores waste. The first part of the colon is the ascending colon, which is attached to the small intestine and the appendix on the right side of the abdomen. The transverse colon runs from the right to the left side of the upper abdomen. The descending colon travels downward on the left side and the sigmoid colon is an S-shaped portion that passes food matter down to the rectum, ...
We previously reported that CIN85, an 85 KDa protein known to be involved in tumor cell migration and metastasis through its interaction with Cbl, associates with MUC1 in tumor cells. MUC1/CIN85 complex also regulates migration and invasion of tumor cells in vitro. Here, we examined specifically human colon carcinoma tissue microarrays (TMA) by immunohistochemistry for the expression of MUC1 and CIN85 and their potential role in cancer progression and metastasis. We detected a significant increase in expression of both MUC1 and CIN85 associated with advanced tumor stage and lymph node metastasis. We further investigated if Cbl could also be present in the MUC1/CIN85 complex. Co-immunoprecipitation assay showed that Cbl co-localized both with CIN85 and with MUC1 in a human colon cancer cell line. To begin to investigate the in vivo relevance of MUC1 overexpression and association with CIN85 and Cbl in cancer development and progression, we used human MUC1 transgenic mice that express MUC1 on the colonic
denotes superscript. Background: This study was conducted to develop a non-invasive orthotopic model for metastasis of colon and rectal cancer using a trans-anal approach that is non-operative, reproducible, and easy to perform. Currently, the most accurate orthotopic representation of metastatic human colon cancer is a cecal injection. The trans-anal model allows for further examination of systemic immune responses, tumor take, and onset of metastasis without prior surgical intervention.. Methods: Sixty (60) Balb/c mice were anesthetized and received gentle anal dilation using blunt tipped forceps at the anal opening. Using a 29 gauge syringe, murine colon cancer parental CT26 (CT26) or luciferase labeled CT26 (CT26-luc) cells were injected submucosally into the distal, posterior rectum (CT26 N=30 and CT26-luc N=30) at various concentrations: 2.5×10(^4), 1×10(^5), or 1×10(^6) in a volume of 50µL. All mice were injected using 100 x magnification. Tumor growth and metastatic development was ...
Background: Mucin, a family of high molecular weight glycoprotein has been implicated in a variety of cancers. MUC13 is a newly identified transmembrane mucin which has shown deregulated expression in gastric and ovarian cancers. However, limited information is available about the role of MUC13 in colon cancer progression. The present study investigated the expression profile, clinical relevance and functional significance of MUC13 expression in colon cancer progression.. Materials and Methods: The MUC13 expression profile was determined by immunohistochemical (IHC) analysis using a novel MUC13 monoclonal antibody (PPZ0020) on a panel of colon cancer tissue microarrays containing non-malignant, colon cancer and liver metastasis tissue samples. Colon cancer cell lines which showed faint (SW480) and high (SW620) MUC13 expression were selected for over-expression and knockdown experiments, respectively, to determine the functional role of MUC13 in colon cancer progression. Functional studies, such ...
Todays guest is Wade Hayes, country singer and advanced colon cancer survivor. He is here with us to help support awareness in colon cancer during Colon Cancer Awareness Month in March—a disease impacting nearly 93,000 people this year. Wade was at the height of his country music career with Billboard hits and a promising road ahead when he was diagnosed with stage IV colon cancer. Like so many people facing a cancer diagnosis, he had to put his life on hold. After successful treatment, the singer is determined to reignite his career. Wade is in NYC launching his brand new album and song ?Go Live Your Life?—an emotional song that he wrote after his oncologist told him he was cancer free. For every download of ?Go Live Your Life? purchased on iTunes, a donation of a $1 will be made to the Colon Cancer Alliance Blue Note Fund, a non-profit that supports colon cancer patients who are currently in treatment. Please go visit the site at www.goliveyourlife.com.
TY - JOUR. T1 - Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells. AU - Pollock, Claire B.. AU - Shirasawa, Senji. AU - Sasazuki, Takehiko. AU - Kolch, Walter. AU - Dhillon, Amardeep S.. PY - 2005/2/15. Y1 - 2005/2/15. N2 - RAS oncegenes are thought to play a role at multiple stages of tumorigenesis. The role and mechanisms by which RAS oncogenes maintain the transformed state of human cancer cells are poorly understood. Here, we have studied the role of oncogenic K-RAS in maintaining cytoskeletal disruption, cell adhesion and motility in metastatic colon carcinoma cells. Targeted deletion of K-RASG13D from HCT116 colon carcinoma cells restored their ability to assemble stress fibers and focal adhesions/complexes, accompanied by increased cell-matrix adhesion and reduced motility. We further show that oncogenic K-Ras induces high Rho activity, but uncouples Rho from stress fiber formation. This uncoupling required the ...
Obesity is a global phenomenon and is associated with various types of cancer, including colon cancer. There is a growing interest for safe and effective bioactive compounds that suppress the risk for obesity-promoted colon cancer. Resveratrol (trans
Colon cancer remains one of the most common malignancies. In the past decades, there have been substantial developments in diagnostic and clinical treatment regimens for colon cancer. However, its prognosis remains poorer than expected. Therefore, there is still a need for the development of new and effective drugs or strategies for colon cancer treatment. In the present study, the effective anticancer activity of Evo, which may be mediated by BMP9 via the upregulation of HIF-1α to partly increase the activity of p53, was demonstrated in human colon cancer.. It has been reported that Evo exhibits great anti-cancer activities in many types of cancer, such as tongue, breast, colon, prostate and lung cancer (9-12,26,27). As far as colon cancer is concerned, the anticancer activity of Evo may be mediated by inactivating the NF-κB (9) or TGF-β1 (11), or activating the p53/p21/Rb pathway (12). Our previous study indicated that the anti-cancer activity of Evo was associated with the downregulation ...
TY - JOUR. T1 - Folic acid inhibits COLO-205 colon cancer cell proliferation through activating the FRα/c-SRC/ERK1/2/NFκB/TP53 pathway. T2 - In vitro and in vivo studies. AU - Kuo, Chun Ting. AU - Chang, Chieh. AU - Lee, Wen Sen. PY - 2015/6/9. Y1 - 2015/6/9. N2 - To investigate the molecular mechanism underlying folic acid (FA)-induced anti-colon caner activity, we showed that FA caused G0/G1 arrest in COLO-205. FA activated the proto-oncogene tyrosine-protein kinase Src (c-SRC)-mediated signaling pathway to enhance nuclear factor of kappa light polypeptide gene enhancer in B-cells (NFκB) nuclear translocation and binding onto the tumor protein p53 (TP53) gene promoter, and up-regulated expressions of TP53, cyclin-dependent kinase inhibitor 1A (CDKN1A) and cyclin-dependent kinase inhibitor 1B (CDKN1B). Knock-down of TP53 abolished FA-induced increases in the levels of CDKN1A and CDKN1B protein and G0/G1 arrest in COLO-205. Knock-down of folate receptor alpha (FRα) abolished FA-induced ...
TY - JOUR. T1 - Serological immunoreactivity against colon cancer proteome varies upon disease progression. AU - De Monte, Lucia. AU - Sanvito, Francesca. AU - Olivieri, Stefano. AU - Viganò, Fiammetta. AU - Doglioni, Claudio. AU - Frasson, Matteo. AU - Braga, Marco. AU - Bachi, Angela. AU - Dellabona, Paolo. AU - Protti, Maria Pia. AU - Alessio, Massimo. PY - 2008/2. Y1 - 2008/2. N2 - Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. A panel of six TAAs eliciting a serological immune response in colorectal cancer was identified, showing a modification in antigen recognition by B cells in patients as a function of colon cancer progression. The expression of these proteins was either confined or increased in tumor as compared to normal mucosa.. AB - Sera from colon carcinoma patients were used to identify tumor-associated antigens (TAAs) by screening tumor proteome resolved by 2D electrophoresis. ...
40 patients were randomised to receive either propofol target controlled infusion with a thoracic epidural at the level of T9-12 or to sevoflurane with intraoperative sufentanyl and postoperative patient controlled analgesia. Venous blood samples were taken preoperatively and 24 hours postoperatively. Both groups were similar in patient demographics and tumour stage. The ability of colon cancer cells to proliferate in the propofol-epidural patients serum was significantly reduced compared to the sevoflurane-opioid patients serum. The number of invasive colon cancer cells and cell viability ratio was significantly reduced in the propofol-epidural exposed patients serum compared to the sevoflurane opioid group serum. Apoptosis of colon cancer cells was significantly reduced in sevoflurane-opioid exposed patients serum. The neutrophil/leukocyte ratio, a marker of inflammation, was lower in patients serum who received propofol-epidural analgesia. ...
Buy our Caco 2 (human colonic carcinoma cell line) whole cell lysate. ab3950 has been validated in western blot. Abcam now offers a 12-month guarantee.
TY - JOUR. T1 - Apoptotic Effects of Drug Targeting Conjugates Containing Different GnRH Analogs on Colon Carcinoma Cells. AU - Lajkó, Eszter. AU - Hegedüs, Rózsa. AU - Mező, G.. AU - Kőhidai, L.. PY - 2019/9/8. Y1 - 2019/9/8. N2 - The wide range of cellular target reactions (e.g., antitumor) of gonadotropin-releasing hormone (GnRH) variants provides the possibility to develop multifunctional GnRH conjugates. The aim of our work was to compare the cytotoxic/apoptotic activity of different GnRH-based, daunorubicin (Dau)-linked conjugates with or without butyrated Lys in position 4 (4Lys(Bu)) at a molecular level in a human colorectal carcinoma cell line. Cell viability was measured by impedimetry, cellular uptake and apoptosis were studied by flow cytometry, and the expression of apoptosis-related genes was analyzed by qRT-PCR. The modification with 4Lys(Bu) resulted in an increased cytotoxic and apoptotic effects and cellular uptake of the GnRH-I and GnRH-III conjugates. Depending on the ...
Published multigene classifiers suggesting outcome prediction for patients with stage UICC II colon cancer have not been translated into a clinical application so far. Therefore, we aimed at validatin
Cancer that forms in the tissues of the colon (the longest part of the large intestine). Most colon cancers are adenocarcinomas (cancers that begin in cells that make and release mucus and other fluids). An estimated 106,000 cases of colon cancer are diagnosed in the United States each year.. For more information, visit the National Cancer Institutes page on colon cancer: http://www.cancer.gov/cancertopics/types/colon-and-rectal.. Treatment at the UAB Comprehensive Cancer Center. Colon cancer patients at the UAB Comprehensive Cancer Center are seen in the centers Multidisciplinary Gastrointestinal Oncology Clinic, located in The Kirklin Clinic of UAB Hospital. The clinic treats all types of GI cancers, including esophageal cancer, stomach cancer, liver cancer, pancreatic cancer, bile duct cancer, colon cancer and rectal cancer, as well as soft-tissue sarcomas and endocrine diseases (thyroid, parathyroid, pancreas and adrenal).. The clinics multidisciplinary approach to treatment provides ...
Colon cancer cells show increased resistance to chemotherapeutic agents compared to breast cancer cells (28, 29), and the molecular mechanisms of this resistance are not fully known. While colon cancer cells express high levels of Src family kinases (30), the survival signal pathways associated with its expression are not known (31). In the present study, we have demonstrated that colon cancer cell lines have survival signals operative through both FAK and Src activities, suggesting that the combination of these signals may contribute to their resistance to apoptosis. Furthermore, these results have shown for the first time that combined dual Src and FAK inhibition is effective for inducing apoptosis in colon cancer cell lines.. Several studies have demonstrated up-regulation of FAK expression in colorectal cancer (11, 13, 14, 24, 25, 32), and it appears that colon cells up-regulate expression of FAK at early stages of tumorigenesis, even before carcinoma has been detected (11). Our previous ...
Weight loss. Metastatic Colon Cancer. Sometimes the cancer cells from one area of the body can spread to other parts of the body this is known as secondary spread or metastasis. The cells of the colon cancer can travel through the lymphatic system or bold stream and can spread to the liver, bones or any other organ. The exact cause of metastatic colon cancer is not known.. Colon Cancer Stages. To diagnose colon cancer the physician may conduct colonoscopy or barium enema X-ray. The polyps detected by colonoscopy, they are removed and sent for biopsy to detect cancer cells. After diagnosis the stage of the cancer is identified. The colon cancer stages are identified using the method called the TNM system. T indicates the size and extent of the primary tumor or degree of invasion of cancer cells into the intestinal wall, N indicates the degree to which the cancer has spread to the lymph nodes and M indicates whether the cancer has metastasized to other organs of the body.. Colon Cancer ...
Weight loss. Metastatic Colon Cancer. Sometimes the cancer cells from one area of the body can spread to other parts of the body this is known as secondary spread or metastasis. The cells of the colon cancer can travel through the lymphatic system or bold stream and can spread to the liver, bones or any other organ. The exact cause of metastatic colon cancer is not known.. Colon Cancer Stages. To diagnose colon cancer the physician may conduct colonoscopy or barium enema X-ray. The polyps detected by colonoscopy, they are removed and sent for biopsy to detect cancer cells. After diagnosis the stage of the cancer is identified. The colon cancer stages are identified using the method called the TNM system. T indicates the size and extent of the primary tumor or degree of invasion of cancer cells into the intestinal wall, N indicates the degree to which the cancer has spread to the lymph nodes and M indicates whether the cancer has metastasized to other organs of the body.. Colon Cancer ...
According to an analysis reported by Amanda Phipps, PhD, MPH, Assistant Professor of Epidemiology at the University of Washington and Assistant Member at Fred Hutchinson Cancer Research Center, Seattle, and colleagues in the Journal of Clinical Oncology, patients with stage III colon cancer who ever smoked had significantly reduced disease-free survival compared with never-smokers.1 The association between smoking and reduced disease-free survival was most marked in patients with BRAF wild-type or KRAS mutant colon cancer. Prior studies have indicated that cigarette smoking is associated with a modestly increased risk for colon cancer, particularly after long durations or high levels of exposure.. Study Details. The study involved 1,968 patients with stage III disease from the North Central Cancer Treatment Group phase III trial N0147 examining FOLFOX (infusional fluorouracil, leucovorin, and oxaliplatin) vs FOLFOX plus cetuximab (Erbitux) as adjuvant therapy. Questionnaires regarding smoking ...
Reuben D Shin, MD, Peter W Marcello, MD. Lahey Hospital & Medical Center. Background: There is an increasing emphasis on colorectal cancer screening and we are finding more large and advanced polyps along with early stage cancers. Traditionally, these lesions may have required colon resections, however new techniques and technology can allow for endoscopic and endolaparoscopic resections. Methods: We present a video of advanced endolaparoscopic resection of colonic neoplasms to demonstrate new techniques and tips.. Conclusion: Advanced endoscopy and combined endolaparoscopy is emerging as an effective and minimally invasive procedure for advanced polyps and early stage colon cancers. As surgical endoscopists, it is important to consider these new techniques in light of continued advancement in this field. ...
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon. ...
If you use this products in your scientific publication, it should be cited in the publication as: Creative Bioarray cat no. If your paper has been published, please click here to submit the Pub Med ID of your paper to get a coupon. ...
Inhibition of colon cancer cell growth by nanoemulsion carrying gold nanoparticles and lycopene Rwei-Fen S Huang,1,2,* Yi-Jun Wei,1,2,* Baskaran Stephen Inbaraj,3 Bing-Huei Chen1,3,4 1Graduate Institute of Nutrition and Food Science, 2Department of Nutritional Science, 3Department of Food Science, 4Graduate Institute of Medicine, Fu Jen University, Taipei, Taiwan *These authors contributed equally to this work Abstract: Lycopene (LP), an important functional compound in tomatoes, and gold nanoparticles (AN), have received considerable attention as potential candidates for cancer therapy. However, the extreme instability and poor bioavailability of LP limits its in vivo application. This study intends to develop a nanoemulsion system incorporating both LP and AN, and to study the possible synergistic effects on the inhibition of the HT-29 colon cancer cell line. LP–nanogold nanoemulsion containing Tween 80 as an emulsifier was prepared, followed by characterization using
But early in colon cancer development, these growth-controlling hormones are "lost" and not expressed, disrupting GCCs activity, and, Dr. Waldman believes, contributing to tumor formation. Using two separate mouse models that mimic the development of colon cancer in people, his team showed that GCC signaling blocks such tumors from forming. According to Dr. Waldman, the group found that GCC stops tumors from forming through two different mechanisms. In one case, it controls cell growth, while in the other, it maintains "regulation of genomic integrity.". In one mouse cancer model, the animals carried mutations in the APC gene, which causes colon polyps that frequently lead to colon cancer. Mice in the other cancer-development model were exposed to a commonly used experimental cancer-causing agent, azoxymethane. "We modeled both ways that humans develop colon cancer, and studied the effects of a lack of GCC on the incidence of colon cancer development," he explains.. "We found that in animals ...
Abstract. The present research included the determination of xanthine oxidase XO in tissues of benign and malignant colon tumor patients. Six samples were collected from patients in surgery unit in Al-Zahrawi hospital in Nineveh Governorate, three of them were benign and the others were malignant colon tumors. The results showed that there are (62%) increase in the specific activity of the enzyme in malignant than benign. The research also included an isolation and partial purification of XO using gel filtration chromatography from benign and malignant colon tumor tissues. The number of purification folds was (12) fold from benign and (17) folds from malignant. The molecular weight of XO was determined using gel filtration on sephadex G-100 and it was found to be (199000 ± 2000 , 191000 ± 2000) dalton from benign and malignant colon tumor respectively. The results also showed that the enzyme gave a maximum activity at (1.5×10-4 M) of xanthine as a substrate and phosphate buffer at pH (8.5), ...
1. R. Blomhoff, T. Gjøen, G. Skretting, H.K. Blomhoff, K.R. Norum and T. Berg (1986). Uptake of retinol and retinol binding protein in hepatic parenchymal cells and perisinusoidal stellate cells. In Cells of the hepatic sinusoid (A. Kirn, D.L. Knook and E. Wisse eds.) Pasmans, Netherlands.. 2. Kaare R. Norum, Rune Blomhoff, Michael H. Green, Joanne B. Green, karl-Olof Wathne, Tor Gjøen, Marie Botilsrud and Trond Berg (1986). Metabolism of retinol in the intestine and liver. In Proceedings from 618th Meeting of Biochemical Society Transactions: Biological Roles of Retinol and other Retinoids.. 3. T. Gjøen, R. Seljelid and S.O. Kolset 1989. Binding of metastatic colon carcinoma cells to liver macrophages. In Cells of the hepatic sinusoid Vol 2 (E. Wisse, D.L. Knook and K. Decker eds) The Kupffer cell foundation. Rijswijk, The Netherlands pp245-246.. 4. Gjøen, T., Holtz, E., Strande, P., Klaveness, J., Leander, P. and Berg, A. Particulate biodegradable contrast medium for CT of the liver. 1991. ...
In May 1999, my youngest sister Elaine was rushed to the emergency room at our local hospital complaining of abdominal pain. Later that evening she underwent urgent surgery to have her colon resected. She unfortunately had advanced colon cancer. Sadly, just one year later, on May 18, 2000, she died, at the young age of 44 years old.. The tragic loss of my youngest sister could have been avoided if she had been screened for colon cancer.. A few years later, when I was 55, a colonoscopy revealed that I too had colon cancer and I required extensive surgery. Thankfully, to date, the cancer has not reappeared.. I was so much luckier. However, having been present throughout my sisters painful battle with colon cancer, I still ask myself why I wasnt more proactive in getting screened long before I was diagnosed with the disease. I guess I felt that it was something that could only happen to someone else. Perhaps I was embarrassed at the thought of having a doctor examine me or perhaps I was ...
In May 1999, my youngest sister Elaine was rushed to the emergency room at our local hospital complaining of abdominal pain. Later that evening she underwent urgent surgery to have her colon resected. She unfortunately had advanced colon cancer. Sadly, just one year later, on May 18, 2000, she died, at the young age of 44 years old.. The tragic loss of my youngest sister could have been avoided if she had been screened for colon cancer.. A few years later, when I was 55, a colonoscopy revealed that I too had colon cancer and I required extensive surgery. Thankfully, to date, the cancer has not reappeared.. I was so much luckier. However, having been present throughout my sisters painful battle with colon cancer, I still ask myself why I wasnt more proactive in getting screened long before I was diagnosed with the disease. I guess I felt that it was something that could only happen to someone else. Perhaps I was embarrassed at the thought of having a doctor examine me or perhaps I was ...
The goal of this study was to characterize p53 tumor suppressor pathway in colon-specific carcinogen azoxymethane (AOM)-induced mouse colon tumor and to assess the usefulness of this animal model to evaluate novel anti-cancer drugs. The acute exposure of mice to AOM showed no overall induction of p53-regulated genes. Subdued p53 gene activation in the colon corresponded to a drop in the expression of its transcriptional co-activator, p300. The status of p53 pathway was further analyzed using AOM-induced mouse colon tumor and the cell line (AJ02-NM0) generated from the primary tumor. Wild type p53 protein, constitutively expressed in this model, showed no detectable DNA binding activity nor did it activate p21 expression. The cell line studies revealed that p53 activity was inhibited by a constitutive interaction with Mdm2. The p53-activating p19/ARF protein did not appear to have significant effect on the standing of p53 pathway in this cell line. p53 was activated by Doxorubicin, 5-FU and the recently
In a study in the PETACC-8 trial population reported in JAMA Oncology, Taieb et al found that the risk of recurrence in patients with stage III colon cancer differed for the primary tumor location according to RAS- and BRAF-mutation status.. Study Details. A total of 2,559 patients were randomized to receive adjuvant FOLFOX (leucovorin, fluorouracil, and oxaliplatin) with or without cetuximab (Erbitux). Of them, 1,900 were screened by next-generation sequencing, with the primary tumor location identified in 1,869. Among them (57% male), 755 (40%) had a right-sided tumor, 164 (10%) had microsatellite instability (MSI), 942 (50%) had RAS mutations, and 212 (11%) had BRAF mutations.. Outcomes. Among all patients, there was no significant difference in disease-free survival for right-sided vs left-sided tumors. However, survival after relapse (hazard ratio [HR] = 1.54, P = .001) and overall survival (HR = 1.25, P = .03) were better for left-sided tumors, with 5-year rates of 31.1% vs 18.5% and 84.2% ...
Despite undergoing complete surgical removal of the cancer, 25-40% of patients with Stage II colon carcinoma experience recurrence of their cancer.
In this case-based interview, Michael Morse, MD, FACP, discusses management of two patients, one with quadruple wild-type unresectable metastatic colon cancer and another with locally advanced disease.
Scientists saw dramatic effects on risk factors for colon cancer when American and African volunteers swapped diets for just two weeks... Western diets,
African-Americans with colon cancer are half as likely as Caucasian patients to have a type of colon cancer that is linked to better outcomes. The finding may provide insight into why African-Americans are more likely to die of colon cancer than Caucasians with the same stage of disease.. The population-based study of 503 people with colon cancer found that 14 percent of Caucasians and 7 percent of African-Americans had a genetic marker called microsatellite instability, or MSI. These types of tumors are known to be resistant to the chemotherapy drug 5FU. Yet, even without chemotherapy, these patients tend to have better outcomes.. "We know that patients with MSI colon cancer do better without chemotherapy. But these improved survival benefits are limited among African-Americans with colon cancer," says lead study author John M. Carethers, M.D., John G. Searle Professor and Chair of internal medicine at the University of Michigan Medical School.. Results of the study appear in the journal PLOS ...
Despite the recognition that colon cancer is largely preventable, it remains the second leading cause of cancer-related deaths in the United States. Historically, screening approaches have sought to detect established cancer, but the identification of precancerous adenomatous polyps is clearly the preferable goal. Not all adenomas progress to cancer, but those that are larger than 1 cm or contain villous histology or high-grade dysplasia are most likely to do so. The current multisociety guidelines now emphasize detection of precancerous polyps as the most effective strategy to prevent deaths from colon cancer, and structural examinations, such as colonoscopy, are recommended for this purpose (1). Testing for occult blood in stool is notoriously insensitive for detecting adenomas (2) ...
More than 20% of patients with resected stage II colon cancer and 50% of patients with resected stage III colon cancer will develop recurrence. To identify markers for recurrence and to find potentially new targets for treatment, mutations were profiled in tumors from NSABP clinical trial C‐07. TypePLEX chemistry and the Mass Array system from Sequenom (SanDiego CA) were used to profile 238 common, hot‐spot, cancer mutations in 19 genes in 239 colon cancer samples utilizing the OncoCarta panel. Mutations were detected in 7 different genes (ABL1, AKT1, BRAF, KRAS, MET, NRAS and PIK3CA) at 26 different nucleotide positions. Twenty‐four assays which detected mutations in more than 1% of the samples were reconfigured into a new multiplexed panel, termed here as ColoCarta, and used to repeat the profiling of 24 mutant samples. These profiles were identical to those found with OncoCarta, demonstrating reproducibility. The method was also sensitive, requiring as little as 1ng of input DNA. In ...
A number of studies have demonstrated that perturbed cellular calcium homeostasis has been implicated in apoptosis. Some studies showed that selenium compounds were able to induce cell apoptosis. The main objective of this study is to evaluate effect of Na2SeO3 on intracellular Ca2+ levels in SW480 human colonic carcinoma cells. When SW480 cells were exposed to 25 to 100 micrometers ol/L Na2SeO3, we also found that Na2SeO3 was able to induce [Ca2+]i, disruption of mitochondrial membrane potential ((Delta) (psi) m) in SW480 cells by using a confocal laser scanning microscope. Ca2+ channel inhibitor CoCl2 and an intracellular Ca2+ chelator BAPTA completely inhibited [Ca2+]i increase. CoCl2, BAPTA and ruthenium red also inhibited disruption of (Delta) (psi) m. The results suggest that Na2SeO3 is able to increase [Ca2+]i mitochondria permeability transition and Ca2+ is from extracellular Ca2+ ...
We start kindergarten around the age of five. We are eligible to get a drivers license at 16. Colon cancer screenings begin around the age of 50.. Guidelines exist for a reason, but they are not always sufficient in providing uniform results. A child could be ready for kindergarten at age 4. Some teenagers are not responsible enough to drive until they turn 17 - or later! And many adults need a colonoscopy before their fiftieth birthday.. According to a study published in JAMA in August 2017, colon cancer rates have been increasing among adults under the age of 55 since the mid-1990s. Even though colon cancer incidence is declining overall, younger people are dying of colon cancer at higher rates than in years past. Among 20 to 54-year-olds, the death rate has risen to 4.3 per 100,000 in 2014 compared to 3.9 per 100,000 in 2004.. Even so, the U.S. Preventative Services Task Force has not altered the recommended age for baseline colonoscopies for men and women who are at average risk for colon ...
Colon cancer survival rates - Survival rates for pancreatic cancer | American Cancer Society. Bowtrol is formulated to maximize ones elimination without causing loose stools or uncomfortable cramping.
Novel chemotherapy and biological agents for metastatic colorectal cancer, combined with surgical advances in liver resection, have resulted in a dramatic increase
My 63 year husband who has advanced colon cancer is now paralysed (found out 2 weeks ago) from his waist downwards and has a catheter and a stoma. The tumours have metatised up his spine. He is home now and we are putting a care package in place but in due to huge expense trying to do as much as possible myself and son. I am trying complimentary therapies to reduce tumours boost his immune system as oncology can do nothing for him but he wont cooperate with the medication saying that its not doing anything. It is recommended by a Dr called Dana Flavin who is very well regarded and is a US physician and pharmacologist based in Germany. Juicing 3 times a day and medication quite a few pills and CBT oil. Id take him to a centre but cant see he would be able to fly anywhere - I will do anything to help me but as you can imagine we are all in a state of dreadful shock and he is very depressed and says he wants to die and not be a burden. We are at the beginning of an unknown journey but would ...
Nodules on colon cancer - Is a 0.5 CM lung nodule in colon cancer pt regarded a small? Can it be ablated? Depends on what. The nodule is. If the nodule is a met from colon cancer, then ablating this apparent solitary nodule is not likely to affect the course of the disease. Calling is small or large is not relevant, the nature of the lesions needs to be ascertained.
In this study,YWHAE expression was silenced by RNA interference in colon cancer cell lines, and investigate the correlation between YWHAE expression and colon cancer proliferation,and differential expressed genes were analized by gene assay and qPCR technologe.The proliferation and colony formation ability of colon cancer cells were significantly reduced after YWHAE knockdown. More 1200 known genes were found to be involved in the YWHAE functions related tumorigenesis by genechip analysis, these genes related to cell proliferation/apoptosis and cell cycle process. qRT-PCR results showed an expression pattern consistent with that of the genechip analysis. Lentivirus-mediated RNA interference was used to knockdown YWHAE expression in colon cancer cell lines. And cell proliferation assays . GeneChip analysis were carried out for mRNA expression profiling, followed, the expressed levels of mRNA and protein were measured by Quantitative real-time polymerase chain reaction (qRT-PCR) and western blot ,
This study is pivotal as research groups seek to educate our geographic areas and communities on the importance of colon cancer education. Currently, colon cancer is the third-leading cause of cancer death in the United States among men and women, but it does not have to remain this way. Through education, communication, and community support, we can help all eligible individuals receive preventative screenings. Talk to your doctor about when you should schedule your first colonoscopy, and be confident in asking your loved ones if they are up-to-date on their screenings. Offering to be a caregiver for a parent, relative or neighbor could save a life, so take action today.. ...
In the first case only the expression level of altered genes is used with standard inference mechanisms (here, we call this approach "combined approach", shortly COMB). In the second case we define dissimilarities among patients due to differences among the COMB data associated to each subject, and evaluate the "inference accuracy" when using this new type of representation; we call this approach "relational approach" (shortly RA). Specifically, our inference is based on "control vs. case" classification tasks. In other words, given a patient x, whose stage is, e.g., stage(x), we evaluate the ability of an inference mechanism to classify that patient either in the same stage (i.e., stage(x)) or in an advanced stage, say stage′,stage(x). Our evaluation (provided through comparisons) is empirical: we first observe the accuracy performance of a state-of-the-art inference method (for instance Support Vector Machine) to forecast the CRC stage progression when patients are represented through the ...
I Was Diagnosed With Colon Cancer at 36 While Raising 5 Daughters Alone : Olivia Newton-John Talks Agonizing Second Battle With Cancer: I Couldnt Walk a Month Ago ...
BioAssay record AID 88942 submitted by ChEMBL: Antiproliferative activity was evaluated by the 72 hr MTT cell viability assay using human colon carcinoma cells (GC3)..
The therapy is aimed at treating a genetic condition called Familial Adenomatous Polyposis, or FAP, which can develop into colon cancer if its left untreated.
A key role for eicosanoid biosynthetic pathways in human cancer development is supported by numerous reports in the literature (Dannenberg and Zakim, 1999; Marks et al., 1999). Clearly, induction of COX-2 and cPLA2 is observed in colonic polyps and carcinomas (Kargman et al., 1995). Moreover, chronic NSAID intake reduces colon cancer incidence in animal models and humans. Colon cancer incidence in the setting of adenomatous polyposis coli (APC) deficiency is markedly reduced in COX-2 deficient (Oshima et al., 1996), and cPLA2-deficient mice (Takaku et al., 2000), and overexpression of COX-2 has been shown to be sufficient for induction of mammary tumors (Liu et al., 2001). We have previously reported enhanced PGE2 production in NSCLC cell lines that correlated with the expression of oncogenic Ras mutations (Heasley et al., 1997). This was mediated through increased expression of cPLA2 and COX-2 proteins. The induction of COX-2 has also been verified in primary human lung cancer specimens (Hida ...
Researchers at Western University have shown how the bacteria primarily responsible for causing strep throat can be used to fight colon cancer. By engineering a streptococcal bacterial toxin to attach itself to tumour cells, they are forcing the immune system to recognize and attack the cancer.. Kelcey Patterson, a PhD Candidate at Western and the lead author on the study, showed that the engineered bacterial toxin could significantly reduce the size of human colon cancer tumours in mice, with a drastic reduction in the instances of metastasis. By using mouse models that are stripped of their immune system, they were able to create a humanized mouse - one that would not only grow human colon cancer cells, but would also support a human immune system, to test the anti-cancer immunotherapy.. The work was directed by John McCormick, PhD, an associate professor in the Department of Microbiology and Immunology at the Schulich School of Medicine & Dentistry and scientist at the Lawson Health ...
Dr. Mathew Meeneghan joins Debbie Bosque at KULM-FM 98.3 to discuss colon cancer on The Doctors Point of View radio show. Dr. Meeneghan talks about colon cancer development, treatment and screening procedures like colonoscopies.
While published data on right sided versus left sided colon cancers are lacking, colon cancers per se have previously been compared with normal mucosa. In this study, we identified differences in gene expression in the colon that characterised left and right sided normal mucosa and adenocarcinomas. Using statistical algorithms provided by the Affymetrix software, we identified sets of genes differentially expressed, as well as genes in common, between right sided and left sided adenocarcinomas.. In this study, we analysed a total of 45 samples (20 normal and 25 tumour samples). The complexity of our study is comparable with colon cancer expression analyses previously described by Alon et al, analysing 22 normal and 40 tumour samples, and by Notterman et al, analysing 18 adenocarcinomas and four adenomas with paired normal tissue, both using Affymetrix GeneChips, as previously discussed.12,13 The reliability of our data (for example, with regard to comparisons of left sided normal mucosa to ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Lin28b is an RNA-binding protein that inhibits biogenesis of tumor-suppressive microRNAs of the let-7 family, and is involved in induction of pluripotency. Although LIN28B has been implicated in cancer, a specific role in colon tumorigenesis has not been elucidated. We have determined that colon tumors exhibit decreased levels of mature let-7 isoforms, and that constitutive let-7 expression inhibits migration and invasion of colon cancer cells in vitro. Importantly, down-regulation of let-7a and let-7b in colon tumors correlates with increased expression of LIN28B, suggesting tumor-promoting properties of this let-7 inhibitor. In order to determine the role of LIN28B in colon cancer, we constitutively expressed LIN28B in immortalized human colonic epithelial cells and colon cancer cell lines via retroviral transduction. We found that constitutive LIN28B expression promotes migration, invasion, and soft-agar colony formation in vitro, as well as differentiated and metastatic phenotypes in vivo.
Jay, welcome to our forum; however it would be nicer to meet you under a different set of circumstances. Is your father being treated at a top notch cancer facility by a top notch doctor for colon cancer? This is so very important. Are they going to two prong or three prong the chemo? This means utilizing two or three different types of chemo on a low dosage level. Different chemos work better for certain cancer cells and it is wise to be getting more than one chemo so that no time is wasted on treatment. How old is your father? Has he had surgery? Believe me HOPE is very important to have; so maintain the hope and let me know how things are going. Warmly, lillian We invite you to take a look at our Album. www.angelfire.com/sc/molangels/index.html ( Very informational, good tips, Molers pictures, art work and much more.... ----- Original Message ----- From: ,[email protected], To: ,[email protected], Sent: Monday, December 25, 2000 9:54 PM Subject: Re: [MOL] chemotherapy for Stage III colon ...
The article discusses research indicating that stilbenes, the phytochemicals in grapes and berries, may help prevent cancer of the colon.. ...
bis-Dehydroxy-Curcumin Triggers Mitochondrial-Associated Cell Death in Human Colon Cancer Cells through ER-Stress Induced Autophagy. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
It suggests a biomarker for colon cancer patients, something ideally physicians can one day screen for as a diagnostic and prognostic tool," said Subramanian.. Subramanian believes the next step will be determining if drugs are able to target miR-182 and -503, as well was what miR-182 and -503 do after suppressing FBXW7. He hopes to develop a clinical test as well as a translational target for treatments to be utilized in a clinical setting.. ###. This study was supported by the Department of Surgery, University of Minnesota Medical School. Patient sets were utilized in partnership with the Mayo Clinic, Rochester, MN.. The University of Minnesota Medical School, with its two campuses in the Twin Cities and Duluth, is a leading educator of the next generation of physicians. Our graduates and the schools 3,800 faculty physicians and scientists advance patient care, discover biomedical research breakthroughs with more than $180 million in sponsored research annually, and enhance health through ...
The major finding in this work is the development and validation of a novel prognostic algorithm based on GIV expression and LVI status to predict recurrence risk in patients with stage II colon cancer. First, we found that patients with T3, pMMR, stage II colon cancer, the subgroup of patients who create the biggest dilemma for adjuvant treatment decision making, can be stratified into low- and high-risk groups using the GIV/LVI risk prediction model with a significant difference observed in 3-year RFS. Second, we found that this GIV/LVI risk stratification model is as good as an "all-clinical" test model in its ability to predict the 3-year recurrence risk; the latter accounts for all clinicopathologic risk factors. It is noteworthy that the "all clinical" model we used here does not represent any gold standard clinical practice, but was used as an internal reference only because we had access to detailed clinicopathologic information in our test cohort. Such an "all clinical" model suffers ...
CD4 T cells inhibit in vivo the CD8-mediated immune response against murine colon carcinoma cells transduced with interleukin-12 genes.: Retroviral-mediated cyt
Cancer that has spread past the lining of the colon and has affected the lymph nodes is considered stage III colon cancer. In this stage, even though the lymph nodes are affected, the cancer has not yet affected other organs in the body. This stage is further divided into three categories: IIIA, IIIB and IIIC. Where your cancer is staged in these categories depends on a complex combination of which layers of the colon wall are affected and how many lymph nodes have been attacked.. Treatment: The course of action for all categories of stage III colon cancer involves surgery to remove the affected areas, and chemotherapy. Radiation treatment may also be recommended for patients who are not healthy enough for surgery or for patients who may still have cancer cells in their bodies after surgery has taken place.. ...
HOUSTON-Colon cancer researchers are studying a variety of cell surface molecules and receptors as potential targets for new treatments aimed particularly at preventing or treating metastatic disease. Lee Ellis, MD, professor of surgery and cancer biology at the University of Texas M. D. Anderson Cancer Center in Houston, discussed his groups current work in three new areas: angiopoietins as a target for blocking tumor angiogenesis, integrins, and the insulin growth factor-1 (IGF-1) system. 1
Reducing the size, weight, and density of stools to the norm, is the most important and effective step toward the goal of preventing colorectal cancer.
The mammalian SPCA1 and SPCA2 ATPases localise in membranes of the secretory pathway and transport ions of Ca2+ and Mn2+. The role of tissue-specific SPCA2 isoform, highly expressed in lungs, mammary gland and gastrointestinal tract, is poorly understood. To elucidate the function of SPCA2, we studied human colon cancer HCT116 cells, grown under ambient and decreased O2 levels. We found that in contrast to other Ca2+-ATPase isoforms the expression of SPCA2 was upregulated under hypoxia (3% O2), in both adherent (2D) and spheroid (3D) cultures. In spheroids, experiencing lowest O2 levels (30-50 μM, measured by phosphorescence lifetime imaging microscopy), we observed lower staining with reactive oxygen species (ROS)-specific fluorescent probe, which correlated with increased SPCA2. However, SPCA2 expression was upregulated in cells exposed to reactive oxygen and nitrogen species donors, and when grown at higher density. We noticed that the culture exposed to hypoxia showed overall increase of S ...
Researchers in the Netherlands have developed a method of accurately predicting which patients with colon cancer are most likely to have their disease recur after surgery and who would, therefore, be likely to benefit from additional chemotherapy. Professor Rob Tollenaar presented the findings at the European Cancer Conference in Barcelona today.
Lipkin M, Deschner E, Troncale F (1970). "Cell differentiation and the development of colonic neoplasms". CA: A Cancer Journal ... "Biochemical measure of the volume doubling time of human pulmonary neoplasms". Cancer. 55 (7): 1530-5. doi:10.1002/1097-0142( ...
Bitterness and Colonic Neoplasms". Digestive Diseases and Sciences. 50 (3): 483-9. doi:10.1007/s10620-005-2462-7. PMID 15810630 ...
April 2002). "Risk of renal and colonic neoplasms and spontaneous pneumothorax in the Birt-Hogg-Dubé syndrome". Cancer ... cosegregation of kidney neoplasms with BHD cutaneous lesions was observed in 3 families with a family history of kidney tumors ...
... violet is absorbed into intestinal and neoplastic cells and is used to identify Barrett's esophagus and colonic neoplasms. ... characterization of colonic polyps and colorectal cancer, and in screening for dysplasia in individuals with ulcerative colitis ...
indicated that macrophages and neutrophils in an inflamed colonic epithelium are the source of reactive oxygen species causing ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The term 'neoplasm' is a synonym of "tumor". 'Neoplasia' denotes the process of the formation of neoplasms/tumors, the process ... "II Neoplasms". World Health Organization. Retrieved 19 June 2014.. *^ a b Abrams, Gerald. "Neoplasia I". Retrieved 23 January ...
... colonic neoplasms MeSH C04.588.274.476.411.307.180.089 --- adenomatous polyposis coli MeSH C04.588.274.476.411.307.180.089.500 ... nose neoplasms MeSH C04.588.149.721.656 --- orbital neoplasms MeSH C04.588.149.721.828 --- skull base neoplasms MeSH C04.588. ... anal gland neoplasms MeSH C04.588.274.476.411.445 --- duodenal neoplasms MeSH C04.588.274.476.411.501 --- ileal neoplasms MeSH ... femoral neoplasms MeSH C04.588.149.721 --- skull neoplasms MeSH C04.588.149.721.450 --- jaw neoplasms MeSH C04.588.149.721. ...
... appendiceal neoplasms MeSH C06.301.371.411.307 --- colorectal neoplasms MeSH C06.301.371.411.307.180 --- colonic neoplasms MeSH ... appendiceal neoplasms MeSH C06.405.249.411.307 --- colorectal neoplasms MeSH C06.405.249.411.307.180 --- colonic neoplasms MeSH ... appendiceal neoplasms MeSH C06.405.469.491.307 --- colorectal neoplasms MeSH C06.405.469.491.307.180 --- colonic neoplasms MeSH ... cecal neoplasms MeSH C06.405.469.110.417.290 --- appendiceal neoplasms MeSH C06.405.469.158 --- colonic diseases MeSH C06.405. ...
... compared to histologically normal tissue from individuals who never had a colonic neoplasm. This finding suggests that ... MBD4 expression is reduced in almost all colorectal neoplasms due to methylation of the promoter region of MBD4. Also MBD4 is ...
... compared to histologically normal tissue from individuals who never had a colonic neoplasm. This indicates that an epigenetic ... MBD4 mRNA expression is reduced in colorectal neoplasms due to methylation of the promoter region of MBD4. A majority of ...
Neoplasms / cancer Diverticulitis / Diverticulosis Hernias Inflammatory bowel disease Colonic volvulus (sigmoid, caecal, ... Pseudoobstruction Hernias containing bowel Crohn's disease causing adhesions or inflammatory strictures Neoplasms, benign or ...
These neoplasms have a characteristic transition of cells. The lining of the cyst consists of basoloid cells with indistinct ... This association has prognostic important since cutaneous findings in children with Gardner Syndrome generally precede colonic ... These neoplasms are relatively uncommon and typically occur on the scalp, face, and upper extremities. Clinically, ... polyposis.[citation needed] Malignant pilomatricoma List of cutaneous conditions List of cutaneous neoplasms associated with ...
Hemorrhoids Neoplasm - such as colorectal cancer Angiodysplasia Bleeding from a site where a colonic polyp was removed ... The presence of fresh blood in the terminal ileum is presumed to indicate a non colonic source of bleeding. The overall ... use is a risk factor for diverticular bleeding and NSAID-induced colonic ulcer; and recent colonoscopy with polypectomy ...
S. bovis and Clostridium septicum, which are part of the natural flora of the bowel, are associated with colonic malignancies. ... colonoscopy to be done immediately due to concerns regarding hematogenous spread of bacteria from the colon due to the neoplasm ...
Cancer - Histopathologic image of colonic carcinoid Precancer - Tubular adenoma (left of image), a type of colonic polyp and a ... As summarized in the articles Carcinogenesis and Neoplasm, for sporadic cancers in general, a deficiency in DNA repair is ... Other microRNAs, with likely comparable numbers of target genes, are even more frequently epigenetically altered in colonic ... Srikumar Chakravarthi; Baba Krishnan; Malathy Madhavan (1999). "Apoptosis and expression of p53 in colorectal neoplasms". ...
Precancer-Tubular adenoma (left of image), a type of colonic polyp and a precursor of colorectal cancer. Normal colorectal ... Srikumar Chakravarthi; Baba Krishnan; Malathy Madhavan (1999). "Apoptosis and expression of p53 in colorectal neoplasms". ... As summarized in the articles Carcinogenesis and Neoplasm, for sporadic cancers in general, a deficiency in DNA repair is ... "Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis". Nature. 363 (6429 ...
It is well documented that malignancy may be only focally present in mucinous neoplasms of the ovary, so thorough sampling is ... The appearance can look similar to colonic cancer. Clear stromal invasion is used to differentiate borderline tumors from ... Mucinous tumors are part of the surface epithelial-stromal tumor group of ovarian neoplasms, and account for approximately 36% ...
Gastric and colonic pacemakers have been tried. These are strips placed along the colon or stomach which create an electric ... Bowel obstruction: mechanical or functional obstruction of the bowel most commonly due to adhesions, hernias or neoplasms. ... Briejer MR, Prins NH, Schuurkes JA (October 2001). "Effects of the enterokinetic prucalopride (R093877) on colonic motility in ... Saunders MD (October 2004). "Acute colonic pseudoobstruction". Current Gastroenterology Reports. 6 (5): 410-6. doi:10.1007/ ...
2009). "Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms". ... the colonic cell line". Biochim. Biophys. Acta. 1498 (1): 32-43. doi:10.1016/s0167-4889(00)00075-6. PMID 11042348. Ciocca V, ...
Neoplasms / cancer. *Diverticulitis / Diverticulosis. *Hernias. *Inflammatory bowel disease. *Colonic volvulus (sigmoid, caecal ...
... s are a class of ovarian neoplasms that may be benign or malignant. Neoplasms in this group are ... The appearance can look similar to colonic or ovarian cancer, but typically originates from the appendix (see mucinous ... One rare but noteworthy condition associated with mucinous ovarian neoplasms is pseudomyxoma peritonei. As primary ovarian ... of all ovarian neoplasms In some cases mucinous tumors are characterized by more cysts of variable size and a rarity of surface ...
Benign neoplasms are typically but not always composed of cells which bear a strong resemblance to a normal cell type in their ... Bowel intussusception can occur with various benign colonic tumors. Cosmetic effects can be caused by tumors, especially those ... ISBN 92-832-2416-7. Gill SS, Heuman DM, Mihas AA (October 2001). "Small intestinal neoplasms". J. Clin. Gastroenterol. 33 (4): ... polyps of the colon are often referred to as benign but they are actually overgrowths of normal tissue rather than neoplasms. ...
Hairy cell leukemia is also a neoplasm of B lymphocytes, but the neoplastic cells have a distinct morphology under the ... Colonic perforation secondary to chronic lymphocytic leukemia infiltration without Richter transformation. Leuk Lymphoma. 2011 ... ISBN 0-7817-5007-5. Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and ...
... and colonic adenomas, a premalignant lesion of colon adenocarcinoma. Furthermore epigenetic silencing of MORT is associated ... lymphoid neoplasm diffuse large B-cell lymphoma, pancreatic adenocarcinoma, rectum adenocarcinoma, skin cutaneous melanoma, and ...
A neoplasm is a tissue whose cells have lost its normal differentiation. They can be either benign growths or malignant growths ... chance of colonic malignancy. Juvenile polyps are hamartomatous polyps which often become evident before twenty years of age, ...
... which may be benign neoplasms) or else a malignant neoplasm (cancer). These neoplasms are also indicated, in the diagram below ... in colon tumors compared to adjacent normal-appearing colonic mucosa, there are about 600 to 800 somatically heritable heavily ... The Hallmarks of Cancer as evolutionary adaptations in a neoplasm[edit]. In their landmark paper, The Hallmarks of Cancer,[3] ... Cells in neoplasms compete for resources, such as oxygen and glucose, as well as space. Thus, a cell that acquires a mutation ...
... see malignant neoplasms). Thus, CpG island hyper/hypo-methylation in the promoters of DNA repair genes are likely central to ... in one study of colon tumors compared to adjacent normal-appearing colonic mucosa, 1,734 CpG islands were heavily methylated in ...
Rectal Neoplasms. Lymphoma, B-Cell. Hodgkin Disease. Colonic Neoplasms. Lymphoma, Mantle-Cell. Lymphoma, B-Cell, Marginal Zone ... Breast Neoplasms. Lymphoma, Follicular. Lymphoma, Non-Hodgkin. ...
Colonic Neoplasms, Rectal Neoplasms Cancer trial. Review trial description, criteria and location information here. ... Pfizer is currently recruiting for the NCT00063427 Colorectal Neoplasms, ...
Disease relevance of Colonic Neoplasms. *The relative risk in men with both cholesterol greater than or equal to 250 mg per ... Biological context of Colonic Neoplasms. *The APC gene on chromosome 5 causing adenomatous polyposis coli represents a minority ... Analytical, diagnostic and therapeutic context of Colonic Neoplasms. *Serum cholesterol levels in adenomatous polyps and cancer ... Gene context of Colonic Neoplasms. *The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon ...
Carcinoembryonic Antigen Present in Human Colonic Neoplasms Serially Propagated in Hamsters. By David M. Goldenberg, Hans J. ... Carcinoembryonic Antigen Present in Human Colonic Neoplasms Serially Propagated in Hamsters. By David M. Goldenberg, Hans J. ... Carcinoembryonic Antigen Present in Human Colonic Neoplasms Serially Propagated in Hamsters Message Subject. (Your Name) has ... Carcinoembryonic antigen, as measured by radioimmunoassay, is present in two different human colonic tumors that have been ...
Advanced EndoLaparoscopic Resection of Colonic Neoplasms: the Latest Techniques and Technology. Reuben D Shin, MD, Peter W ... Methods: We present a video of advanced endolaparoscopic resection of colonic neoplasms to demonstrate new techniques and tips. ...
Clinical trial for Colonic Neoplasms , Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis ...
Malignant neoplasm of colon , GASTROINTESTINAL DISORDER , Gastrointestinal Neoplasm , Esophageal Cancer , Duodenal Polyp , ... within the gastrointestinal tract for endoscopic treatment of early gastrointestinal neoplasms involving the resection of the ... Endoscopic resection can be an appropriate approach in early neoplasms, challenging adenomas or sub-epithelial lesions. ...
Rapid induction of colonic neoplasms in ICR mice treated with azoxymethane followed by dextran sodium sulfate. Takuji Tanaka, ... Besides these neoplasms, dysplastic lesions and aberrabt crypt foci (ACF) developed in the colonic mucosa and the frequency of ... Rapid induction of colonic neoplasms in ICR mice treated with azoxymethane followed by dextran sodium sulfate ... Rapid induction of colonic neoplasms in ICR mice treated with azoxymethane followed by dextran sodium sulfate ...
Bordonaro M, Lazarova D. Hypothesis: Induction of biomarkers for detection of colonic neoplasms. J Cancer 2018; 9(1):166-173. ... The concept of detecting inducible markers of colonic neoplasms is novel, and is substantiated by the significant physiological ... Hypothesis: Induction of biomarkers for detection of colonic neoplasms Michael Bordonaro, Darina Lazarova✉ ... We posit that gCD and propolis induce the release of neoplasm-associated biomarkers in systemic circulation (e.g., metabolites ...
Robotic excision of a colonic neoplasm with ICG as a tumor localizer and colonoscopic assistance. Zeitschrift:. Techniques in ... Robotic excision of a colonic neoplasm with ICG as a tumor localizer and colonoscopic assistance ... Nagata J, Fukunaga Y, Akiyoshi T, Konishi T, Fujimoto Y, Nagayama S, Yamamoto N, Ueno M (2016) Colonic marking with near- ... Watanabe M, Murakami M, Ozawa Y, Yoshizawa S, Matsui N, Aoki T (2017) Intraoperative identification of colonic tumor sites ...
... On-line free medical diagnosis assistant. Ranked list of possible diseases ... "colonic neoplasms"Drugs, active principles and "colonic neoplasms"Medicinal plantsQuestions and answers from other usersNews ... Colonic neoplasms (Cancer of Colon; Colon Cancer). Tumors or cancer of the colon. ...
Elias, H & Hyde, DM 1982, Separation and spread of nuclear fragments ("nucleotesimals") in colonic neoplasms, Human Pathology ... Elias, Hans ; Hyde, Dallas M. / Separation and spread of nuclear fragments ("nucleotesimals") in colonic neoplasms. In: Human ... Elias, H., & Hyde, D. M. (1982). Separation and spread of nuclear fragments ("nucleotesimals") in colonic neoplasms. Human ... Separation and spread of nuclear fragments ("nucleotesimals") in colonic neoplasms. Human Pathology. 1982;13(7):635-639. https ...
Colonic Neoplasms Resource Information The concept Colonic Neoplasms represents the subject, aboutness, idea or notion of ... Colonic Neoplasms,/a,,/span, - ,span property=potentialAction typeOf=OrganizeAction,,span property=agent typeof= ... Colonic Neoplasms,/a,,/span, - ,span property=potentialAction typeOf=OrganizeAction,,span property=agent typeof= ... Colonic Neoplasms. Local Identifier. http://link.collegeofphysicians.org/resource/555ZNmLP-iE/ Network Identifier. http:// ...
Colonic Neoplasms. Colorectal Neoplasms. Intestinal Neoplasms. Gastrointestinal Neoplasms. Digestive System Neoplasms. ... Neoplasms by Site. Neoplasms. Digestive System Diseases. Gastrointestinal Diseases. Colonic Diseases. Intestinal Diseases. ... SEMS Placement Followed by Chemotherapy and Surgery for Obstructing Left-sided Colonic Cancer. The safety and scientific ... Left-sided colonic tumor. Intestinal obstruction. Self-expanding metallic stent. Neoadjuvant chemotherapy. Stoma. ...
Colonic Neoplasms. Signs and Symptoms. Colorectal Neoplasms. Intestinal Neoplasms. Gastrointestinal Neoplasms. Digestive System ... Neoplasms by Site. Neoplasms. Digestive System Diseases. Gastrointestinal Diseases. Colonic Diseases. Intestinal Diseases. ... Following open colonic surgery patients are fatigued and loss body mass and have a reduction in physical function, but the ... Patients undergoing laparoscopic colonic surgery are compared with a historical cohort of patients undergoing similar open ...
List of variants reported as likely benign for colonic neoplasm by Pathway Genomics Included ClinVar conditions (19):* ... Gastric polyposis; Duodenal polyposis; Adenomatous colonic polyposis; Intestinal polyp; Hyperplastic colonic polyposis ... Colorectal polyposis; Neoplasm of the colon. *Desmoid disease, hereditary; Carcinoma of colon; Familial adenomatous polyposis 1 ... Adenomatous colonic polyposis. *Adrenocortical carcinoma, hereditary; Familial cancer of breast; Glioma susceptibility 1; ...
Adenoma, Animals, Body Weight, Colonic Neoplasms, Colonic Polyps, Female, Glucagon-Like Peptide 2, Glucagon-Like Peptides, ... Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice. Research output: Contribution to journal ... AIMS: In the present study, the effects of GLP-2 treatment on the growth of chemically induced colonic neoplasms were ... RESULTS: Colonic polyps developed in 100% of the mice, regardless of treatment. Survival data revealed no statistical ...
Brain Neoplasms. D001932. EFO:0003833. brain neoplasm. 1. ClinicalTrials. Colonic Neoplasms. D003110. EFO:1001950. colon ... Skin Neoplasms. D012878. EFO:0004198. skin neoplasm. 2. ClinicalTrials. ClinicalTrials. Head and Neck Neoplasms. D006258. EFO: ...
Colonic Neoplasms. D003110. EFO:0004288. colonic neoplasm. 2. ClinicalTrials. Dermatomyositis. D003882. EFO:0000557. juvenile ... Neoplasms. D009369. EFO:0000616. neoplasm. 4. ATC. Scleroderma, Systemic. D012595. EFO:0000717. systemic scleroderma. 2. ... Breast Neoplasms. D001943. EFO:0003869. breast neoplasm. 2. ClinicalTrials. Diabetic Neuropathies. D003929. EFO:1000783. ... Pancreatic Neoplasms. D010190. EFO:0003860. pancreatic neoplasm. 2. ClinicalTrials. Pemphigoid, Benign Mucous Membrane. D010390 ...
Colonic Neoplasms. D003110. EFO:0004288. colonic neoplasm. 3. ClinicalTrials. Glioma. D005910. EFO:0000326. central nervous ... Colonic Neoplasms. D003110. EFO:1001950. colon carcinoma. 3. ClinicalTrials. Hematologic Neoplasms. D019337. EFO:0001642. ... Stomach Neoplasms. D013274. EFO:0003897. stomach neoplasm. 3. ClinicalTrials. Anus Neoplasms. D001005. EFO:0003835. anal ... Peritoneal Neoplasms. D010534. EFO:1001100. peritoneal neoplasm. 2. ClinicalTrials. Rectal Neoplasms. D012004. EFO:1000657. ...
Colonic neoplasms; cytokines; glycolytic metabolism; intestinal epithelial cells; macrophage; tumorigenesis. PMID:. 32056981. ...
Colonic Neoplasms. D003110. EFO:1001950. colon carcinoma. 3. ClinicalTrials. Irritable Bowel Syndrome. D043183. EFO:0000555. ...
Colonic Neoplasms. D003110. EFO:1001950. colon carcinoma. 2. ClinicalTrials. Sarcoma, Ewing. D012512. EFO:0000174. Ewing ... Brain Neoplasms. D001932. EFO:0003833. brain neoplasm. 3. ClinicalTrials. Depressive Disorder. D003866. EFO:0003761. unipolar ... Ovarian Neoplasms. D010051. EFO:0001075. ovarian carcinoma. 2. ClinicalTrials. Substance-Related Disorders. D019966. EFO: ...
Colonic Neoplasms. D003110. EFO:0004288. colonic neoplasm. 3. ClinicalTrials. Multiple Myeloma. D009101. EFO:0001378. multiple ... Breast Neoplasms. D001943. EFO:0003869. breast neoplasm. 3. ClinicalTrials. Colonic Neoplasms. D003110. EFO:1001950. colon ... Neoplasms. D009369. EFO:0000616. neoplasm. 4. ATC. ClinicalTrials. Pancreatic Neoplasms. D010190. EFO:0002618. pancreatic ... Colorectal Neoplasms. D015179. EFO:0004142. colorectal neoplasm. 3. ClinicalTrials. Colorectal Neoplasms. D015179. EFO:1001951 ...
Colonic Neoplasms. D003110. EFO:0004288. colonic neoplasm. 2. ClinicalTrials. Lymphoma, Large-Cell, Anaplastic. D017728. EFO: ... Colonic Neoplasms. D003110. EFO:1001950. colon carcinoma. 1. ClinicalTrials. Diabetes Mellitus, Type 1. D003922. EFO:0001359. ... Uterine Neoplasms. D014594. EFO:0003859. uterine neoplasm. 1. ClinicalTrials. Acute Lung Injury. D055371. EFO:0004610. acute ... Neoplasms. D009369. EFO:0000616. neoplasm. 4. ClinicalTrials. ATC. ClinicalTrials. Histiocytoma. D051642. EFO:0005561. ...
  • The study will be conducted on 30 adult patients aged grater than 18 years, of both genders who have undergone surgical resection of colonic neoplastic lesions without metastatic lesion. (clinicaltrials.gov)
  • Neoplasm is an abnormal growth of tissue which, if it forms a mass, is commonly referred to as a tumor. (wikipedia.org)
  • Current English, however, both medical and non-medical, uses tumor as a synonym for a neoplasm (a solid or fluid-filled cystic lesion that may or may not be formed by an abnormal growth of neoplastic cells) that appears enlarged in size. (wikipedia.org)
  • Patterns of cell proliferation were defined by dividing the colonic crypt into longitudinal compartments and comparing the numbers and fractions of tritiated thymidine--labeled epithelial cells in the various compartments. (nih.gov)
  • This is a single Institution prospective randomized controlled trial comparing the outcomes in patients undergoing laparoscopic right colectomy with IIA or EIA for right colon neoplasm. (clinicaltrials.gov)
  • Immunohistochemical investigation of such dysplasias and neoplasms revealed that all lesions expressed positive reactivities against β-catenin, cyclooxygenase-2, and inducible nitric oxide synthase, but did not show p53 immunoreactivity. (aacrjournals.org)
  • For lymphoid neoplasms, e.g. lymphoma and leukemia, clonality is proven by the amplification of a single rearrangement of their immunoglobulin gene (for B cell lesions) or T cell receptor gene (for T cell lesions). (wikipedia.org)
  • We posit that gCD and propolis induce the release of neoplasm-associated biomarkers in systemic circulation (e.g., metabolites, neoplastic, apoptotic, and immune response proteins), and these markers could be used to detect early stage intestinal neoplasms. (jcancer.org)
  • However, growth stimulation of the intestinal system may accelerate the growth of existing neoplasms in the intestine. (ku.dk)
  • Crystal violet is absorbed into intestinal and neoplastic cells and is used to identify Barrett's esophagus and colonic neoplasms. (wikipedia.org)
  • Male Crj: CD-1 (ICR) mice were given a single and low dose of a genotoxic colonic carcinogen azoxymethane (AOM, 10 mg/kg bw, i.p. injection) followed by one-week oral exposure (2% in drinking water) of a non-genotoxic carcinogen dextran sodium sulfate (DSS) to develop an efficient and rapid animal model for colon carcinogenesis. (aacrjournals.org)
  • The World Health Organization classifies these disorders into a) Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1 (i.e. high eosinophil blood counts caused by mutations in the eosinophil cell line of one of these three genes), 'b) Chronic eosinophilic leukemia, and c) the Idiopathic hypereosinophiic syndrome. (wikipedia.org)
  • Advances in cytogenetics facilitated discovery of chromosome abnormalities in neoplasms, including the Philadelphia chromosome in chronic myelogenous leukemia and translocations in acute myeloblastic leukemia. (wikipedia.org)
  • Bordonaro M, Lazarova D. Hypothesis: Induction of biomarkers for detection of colonic neoplasms. (jcancer.org)
  • Colonic adenocarcinomas were seen in 2 of 5 mice (40% incidence with 2.0 ± 3.5 multiplicity) at Wk 4. (aacrjournals.org)
  • METHODS: In 210 female C57bl mice, colonic tumours were initially induced with the methylating carcinogen 1,2-dimethylhydrazine (DMH) and mice were then treated with GLP-2. (ku.dk)
  • Following open colonic surgery patients are fatigued and loss body mass and have a reduction in physical function, but the investigators do not know if this is also the case following laparoscopic surgery. (clinicaltrials.gov)
  • Here we showed that Gpr109a signaling promoted anti-inflammatory properties in colonic macrophages and dendritic cells and enabled them to induce differentiation of Treg cells and IL-10-producing T cells. (nih.gov)
  • AIMS: In the present study, the effects of GLP-2 treatment on the growth of chemically induced colonic neoplasms were investigated. (ku.dk)