Tumors or cancer of the COLON.
Hydrazines substituted with two methyl groups in any position.
Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.
A benign epithelial tumor with a glandular organization.
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Neoplasms containing cyst-like formations or producing mucin or serum.
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Tumors or cancer of the SKIN.
Passage of food (sometimes in the form of a test meal) through the gastrointestinal tract as measured in minutes or hours. The rate of passage through the intestine is an indicator of small bowel function.
Functional obstruction of the COLON leading to MEGACOLON in the absence of obvious COLONIC DISEASES or mechanical obstruction. When this condition is acquired, acute, and coexisting with another medical condition (trauma, surgery, serious injuries or illness, or medication), it is called Ogilvie's syndrome.
A pathological condition characterized by the presence of a number of COLONIC DIVERTICULA in the COLON. Its pathogenesis is multifactorial, including colon aging, motor dysfunction, increases in intraluminal pressure, and lack of dietary fibers.
Tumors or cancers of the KIDNEY.
The motor activity of the GASTROINTESTINAL TRACT.
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Discrete abnormal tissue masses that protrude into the lumen of the DIGESTIVE TRACT or the RESPIRATORY TRACT. Polyps can be spheroidal, hemispheroidal, or irregular mound-shaped structures attached to the MUCOUS MEMBRANE of the lumen wall either by a stalk, pedunculus, or by a broad base.
A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
An alkylating carcinogen that produces gastrointestinal and probably lung and nervous system tumors.
Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.
A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.
An absorbable suture material used also as ligating clips, as pins for internal fixation of broken bones, and as ligament reinforcement for surgically managed ligament injuries. Its promising characteristics are elasticity, complete biodegradability, and lack of side effects such as infections.
Excision of the gallbladder through an abdominal incision using a laparoscope.
Excision of a portion of the colon or of the whole colon. (Dorland, 28th ed)
Therapeutic modalities frequently used in PHYSICAL THERAPY SPECIALTY by PHYSICAL THERAPISTS or physiotherapists to promote, maintain, or restore the physical and physiological well-being of an individual.
The relative amounts of various components in the body, such as percentage of body fat.
A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Cell surface receptors for obesity factor (LEPTIN), a hormone secreted by the WHITE ADIPOCYTES. Upon leptin-receptor interaction, the signal is mediated through the JAK2/STAT3 pathway to regulate food intake, energy balance and fat storage.
(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.
A type of asbestos that occurs in nature as the dihydrate of magnesium silicate. It exists in two forms: antigorite, a plated variety, and chrysotile, a fibrous variety. The latter makes up 95% of all asbestos products. (From Merck Index, 11th ed, p.893)
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
A lavender, acid-resistant asbestos.
A class of asbestos that includes silicates of magnesium, iron, calcium, and sodium. The fibers are generally brittle and cannot be spun, but are more resistant to chemicals and heat than ASBESTOS, SERPENTINE. (From Hawley's Condensed Chemical Dictionary, 11th ed)
A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.
Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.
A publication issued at stated, more or less regular, intervals.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and inducer of systemic anaphylactic symptoms, including HYPOTENSION; THROMBOCYTOPENIA; NEUTROPENIA; and BRONCHOCONSTRICTION.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).

Classification of human colorectal adenocarcinoma cell lines. (1/11349)

Eleven human colorectal adenocarcinoma cell lines established in this laboratory were classified into three groups based on morphological features (light and electron microscopy), modal chromosome number, and ability to synthesize carcinoembryonic antigen (CEA). Group 1 cell lines contained both dedifferentiated and differentiating cells growing in tight clusters or islands of epithelium-like cells; their modal chromosome number was about 47, and they synthesized small to moderate amounts of CEA. Group 2 cell lines were more dedifferentiated, were hyperdiploid, and synthesized small amounts of CEA. Group 3 cell lines were morphologically similar to those of Group 1 by light microscopy. They differed ultrastructurally by containing microvesicular bodies; the modal chromosome number varied from hyperdiploid to hypertriploid or they had bimodal populations of hypodiploid and hypertriploid cells, and they synthesized relatively large amounts of CEA. No correlation could be found between Broder's grade or Duke's classification of the original tumor and modal chromosome number or ability to synthesize CEA. These findings support Nowell's hypothesis that the stem line is different for each solid tumor, which makes it difficult to relate chromosomal changes to the initiation of the neoplastic state.  (+info)

PKCdelta acts as a growth and tumor suppressor in rat colonic epithelial cells. (2/11349)

We have analysed the expression of three calcium-independent isoforms of protein kinase C (PKC), PKCdelta, PKCepsilon and PKCzeta, in an in vitro model of colon carcinogenesis consisting of the nontumorigenic rat colonic epithelial cell line D/WT, and a derivative src-transformed line D/src. While PKCzeta and PKCepsilon showed similar protein levels, PKCdelta was markedly decreased in D/src cells when compared to the D/WT line. To assess whether down-regulation of PKCdelta was causally involved in the neoplastic phenotype in D/src cells, we prepared a kinase-defective mutant of PKCdelta. Stable transfection of this sequence caused morphological and growth changes characteristic of partial transformation in D/WT cells. Moreover, to test whether PKCdelta was involved in growth control and transformation in this model, we overexpressed PKCdelta in D/src cells. Transfected cells underwent marked growth and morphological modifications toward the D/WT phenotype. In a late stage in culture, transfected cells ceased to proliferate, rounded up and degenerated into multinucleated, giant-like cells. We conclude that PKCdelta can reverse the transformed phenotype and act as a suppressor of cell growth in D/src cells. Moreover, our data show that downregulation of this isoenzyme of PKC may cooperate in the neoplastic transformation induced by the src oncogene in D/WT cells.  (+info)

The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells. (3/11349)

The acquisition of invasiveness is a crucial step in the malignant progression of cancer. In cancers of the colon and of other organs the E-cadherin/catenin complex, which is implicated in homotypic cell-cell adhesion as well as in signal transduction, serves as a powerful inhibitor of invasion. We show here that one allele of the alphaE-catenin (CTNNA1) gene is mutated in the human colon cancer cell family HCT-8, which is identical to HCT-15, DLD-1 and HRT-18. Genetic instability, due to mutations in the HMSH6 (also called GTBP) mismatch repair gene, results in the spontaneous occurrence of invasive variants, all carrying either a mutation or exon skipping in the second alphaE-catenin allele. The alphaE-catenin gene is therefore, an invasion-suppressor gene in accordance with the two-hit model of Knudsen for tumour-suppressor genes.  (+info)

Mechanisms related to [18F]fluorodeoxyglucose uptake of human colon cancers transplanted in nude mice. (4/11349)

[18F]Fluorodeoxyglucose ([18F]FDG), a glucose analogue, has been widely used for tumor imaging. To investigate the mechanisms related to [18F]FDG uptake by tumors, an experiment involving nude mice was performed. METHODS: Human colon cancer cell lines SNU-C2A, SNU-C4 and SNU-C5 were transplanted to nude mice. Using immunohistochemical staining and Western blot, the expression of glucose transporter (Glut) isoforms (Glut-1 through -5) in xenografted tumors was analyzed. For the analysis of messenger ribonucleic acid (mRNA) expression, reverse-transcription polymerase chain reaction and Northern blot were used and the enzyme activity of hexokinase in cancer tissues was measured by continuous spectrophotometric rate determination. RESULTS: [18F]FDG uptake in SNU-C4 and SNU-C5 cells was higher than in normal colon cells. Among these cells and xenografted tumors, SNU-C5 showed the highest level of [18F]FDG uptake, followed by SNU-C4 and SNU-C2A. An immunostaining experiment showed intense staining of Glut-1 in SNU-C5 tumors but somewhat faint staining in SNU-C4. SNU-C5 tumors also showed positive staining with Glut-3, although this was not the case with SNU-C2A and SNU-C4. Western blot analysis showed the expression of Glut-1 and Glut-3 in all tumors. Experiments involving Northern blot analysis and reverse-transcription polymerase chain reaction confirmed the overexpression of Glut-1 mRNA in all tumors, with the highest level in SNU-C5. The level of Glut-3 mRNA was also elevated in SNU-C5 tumors but not in SNU-C2A and SNU-C4. The enzyme activity of hexokinase did not vary among different tumors. CONCLUSION: Gluts, especially Glut-1, are responsible for [18F]FDG uptake in a nude mouse model of colon cancer rather than hexokinase activity. Increased numbers of glucose transporters at the plasma membrane of cancer cells is attributed to an increased level of transcripts of glucose transporter genes and may be a cause of increased [18F]FDG uptake, at least in colon cancer tumors.  (+info)

In vivo isolated kidney perfusion with tumour necrosis factor alpha (TNF-alpha) in tumour-bearing rats. (5/11349)

Isolated perfusion of the extremities with high-dose tumour necrosis factor alpha (TNF-alpha) plus melphalan leads to dramatic tumour response in patients with irresectable soft tissue sarcoma or multiple melanoma in transit metastases. We developed in vivo isolated organ perfusion models to determine whether similar tumour responses in solid organ tumours can be obtained with this regimen. Here, we describe the technique of isolated kidney perfusion. We studied the feasibility of a perfusion with TNF-alpha and assessed its anti-tumour effects in tumour models differing in tumour vasculature. The maximal tolerated dose (MTD) proved to be only 1 microg TNF-alpha. Higher doses appeared to induce renal failure and a secondary cytokine release with fatal respiratory and septic shock-like symptoms. In vitro, the combination of TNF-alpha and melphalan did not result in a synergistic growth-inhibiting effect on CC 531 colon adenocarcinoma cells, whereas an additive effect was observed on osteosarcoma ROS-1 cells. In vivo isolated kidney perfusion, with TNF-alpha alone or in combination with melphalan, did not result in a significant anti-tumour response in either tumour model in a subrenal capsule assay. We conclude that, because of the susceptibility of the kidney to perfusion with TNF-alpha, the minimal threshold concentration of TNF-alpha to exert its anti-tumour effects was not reached. The applicability of TNF-alpha in isolated kidney perfusion for human tumours seems, therefore, questionable.  (+info)

Cancer risk in close relatives of women with early-onset breast cancer--a population-based incidence study. (6/11349)

Inherited susceptibility to breast cancer is associated with an early onset and bilateral disease. The extent of familial risks has not, however, been fully assessed in population-based incidence studies. The purpose of the study was to quantify the risks for cancers of the breast, ovary and other sites of close relatives of women in whom breast cancer was diagnosed at an early age. Records collected between 1943 and 1990 at the Danish Cancer Registry were searched, and 2860 women were found in whom breast cancer was diagnosed before age 40. Population registers and parish records were used to identify 14 973 parents, siblings and offspring of these women. Cancer occurrence through to 31 December 1993 was determined within the Cancer Registry's files and compared with national incidence rates. Women with early-onset breast cancer were at a nearly fourfold increased risk of developing a new cancer later in life (268 observed vs. 68.9 expected). The excess risk was most evident for second cancer of the breast (181 vs. 24.5) and for ovarian cancer (20 vs. 3.3). For mothers and sisters, risks for cancers of the breast and ovary were significantly increased by two- to threefold. Bilateral breast cancer and breast-ovarian cancer were very strong predictors of familial risks, with one in four female relatives predicted to develop breast and/or ovarian cancer by age 75. Mothers had a slightly increased risk of colon cancer, but not endometrial cancer. The risk for breast cancer was also increased among fathers (standardized incidence ratio 2.5; 95% CI 0.5-7.4) and especially brothers (29; 7.7-74), although based on small numbers. The risk for prostatic cancer was unremarkable. In this large population-based survey, the first-degree relatives of women who developed breast cancer before age 40 were prone to ovarian cancer as well as male and female breast cancer, but not other tumours that may share susceptibility genes with breast cancer.  (+info)

Bombesin stimulates adhesion, spreading, lamellipodia formation, and proliferation in the human colon carcinoma Isreco1 cell line. (7/11349)

The neuropeptide bombesin and its mammalian homologue, gastrin-releasing peptide (GRP), enhance proliferation in some but not all human tumor cell lines. The pathophysiological relevance of the bombesin/GRP receptor (GRP-R), which is expressed in 30% of human colon tumor cell lines and in 24-40% of native tumors, has not been clearly assessed at this time. We studied the effects of bombesin in the recently characterized human colon carcinoma Isreco1 cell line. Competitive reverse transcription-PCR showed a high GRP-R mRNA level in Isreco1 cells, and binding studies confirmed the expression of bombesin/GRP-subtype receptors (Kd = 0.42 nM; Bmax = 18,000 sites/cell). Exposure to bombesin resulted in an increase of intracellular calcium concentrations. Bombesin (1 nM) induced cell spreading at 24 h (21.7+/-1.6% versus 6.4+/-0.8% in control cells; P<0.01) and markedly increased the formation of lamellipodia. In addition, adhesion of Isreco1 cells to collagen I-coated culture dishes was stimulated in the presence of 1 nM bombesin (69+/-6% versus 42+/-1% in control cells; P<0.01). Finally, bombesin significantly increased [3H]thymidine uptake by Isreco1 cells in a dose-dependent manner, with a first significant response at 0.1 nM and a maximal effect at 100 nM bombesin (192.2+/-9.7% of control). These results clearly indicate that bombesin exerts morphological, adhesive, and proliferative effects on Isreco1 cells, suggesting that expression of the bombesin/GRP-R may contribute to the malignant properties of colon carcinoma cells.  (+info)

Telomeric repeats on small polydisperse circular DNA (spcDNA) and genomic instability. (8/11349)

Small polydisperse circular DNA (spcDNA) is a heterogeneous population of extrachromosomal circular molecules present in a large variety of eukaryotic cells. Elevated amounts of total spcDNA are related to endogenous and induced genomic instability in rodent and human cells. We suggested spcDNA as a novel marker for genomic instability, and speculated that spcDNA might serve as a mutator. In this study, we examine the presence of telomeric sequences on spcDNA. We report for the first time the appearance of telomeric repeats in spcDNA molecules (tel-spcDNA) in rodent and human cells. Restriction enzyme analysis indicates that tel-spcDNA molecules harbor mostly, if not exclusively, telomeric repeats. In rodent cells, tel-spcDNA levels are higher in transformed than in normal cells and are enhanced by treatment with carcinogen. Tel-spcDNA is also detected in some human tumors and cell lines, but not in others. We suggest, that its levels in human cells may be primarily related to the amount of the chromosomal telomeric sequences. Tel-spcDNA may serve as a unique mutator, through specific mechanisms related to the telomeric repeats, which distinguish it from the total heterogeneous spcDNA population. It may affect telomere dynamics and genomic instability by clastogenic events, alterations of telomere size and sequestration of telomeric proteins.  (+info)

In patients with locally advanced colon cancer (high risk stage II and stage III), curative surgery followed by adjuvant FOLFOX-4 chemotherapy has become the standard of care. However, for 30-40% of these patients, the current curative treatment strategy of surgical excision followed by adjuvant chemotherapy fails either to clear locoregional spread or to eradicate distant micrometastases, leading to disease recurrence. Preoperative chemotherapy is an attractive concept for locally advanced colon cancer and has the potential to impact upon both of these causes of failure. Optimum systemic therapy at the earliest possible opportunity may be more effective at eradicating distant metastases than the same treatment given after the delay and immunological stress of surgery. Added to this, shrinking the primary tumor before surgery may reduce the risk of incomplete surgical excision, and the risk of tumor cell shedding during surgery.. ECKINOXE is a multicenter randomized phase II trial designed to ...
In patients with locally advanced colon cancer (high risk stage II and stage III), curative surgery followed by adjuvant FOLFOX-4 chemotherapy has become the standard of care. However, for 30-40% of these patients, the current curative treatment strategy of surgical excision followed by adjuvant chemotherapy fails either to clear locoregional spread or to eradicate distant micrometastases, leading to disease recurrence. Preoperative chemotherapy is an attractive concept for locally advanced colon cancer and has the potential to impact upon both of these causes of failure. Optimum systemic therapy at the earliest possible opportunity may be more effective at eradicating distant metastases than the same treatment given after the delay and immunological stress of surgery. Added to this, shrinking the primary tumor before surgery may reduce the risk of incomplete surgical excision, and the risk of tumor cell shedding during surgery.. ECKINOXE is a multicenter randomized phase II trial designed to ...
TY - JOUR. T1 - Molecular mechanisms of econazole-induced toxicity on human colon cancer cells. T2 - G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways. AU - Ho, Yuan Soon. AU - Wu, Chih Hsiung. AU - Chou, Hsiao Min. AU - Wang, Ying Jan. AU - Tseng, How. AU - Chen, Chien Ho. AU - Chen, Li Ching. AU - Lee, Chia Hwa. AU - Lin, Shyr Yi. PY - 2005/10. Y1 - 2005/10. N2 - Econazole (Eco), a potent broad-spectrum anti-fungal agent, has been used in the treatment of superficial mycosis. Eco is a store-operated Ca2+ channel antagonist which induces cytotoxic cell death of leukemia. However, little is known about its cytotoxic effect upon solid tumor cells. The purpose of this study is to investigate both the in vitro and in vivo molecular mechanisms of Eco-induced toxicity on colon cancer cells. We used COLO 205 cell line and nude mice xenograft model to investigate the cytotoxic effect of Eco. We demonstrated that lower doses Eco (5-20 μM) arrested human colon cancer cells ...
Screening for the antiproliferative activity of extracts of marine invertebrates on human colon cancer cell lines Conference Poster 2016 ...
Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis.: Patients with mucinou
BioAssay record AID 86084 submitted by ChEMBL: In vitro cytotoxicity against human colon adenocarcinoma cell line HT-29 at 5.9*10e-5M.
The American Cancer Society and the Cigna Foundation have awarded $232,000 to MedStar Washington Hospital Center to address advanced colon cancer.
Genes May Determine Aspirins Effect on Advanced Colon Cancer, Harvard School of Public Health Study - read this article along with other careers information, tips and advice on BioSpace
This page provides useful content and local businesses that can help with your search for Colon Cancer Treatment. You will find helpful, informative articles about Colon Cancer Treatment, including Colon Cancer. You will also find local businesses that provide the products or services that you are looking for. Please scroll down to find the local resources in Lakeville, MN that will answer all of your questions about Colon Cancer Treatment.
This page provides useful content and local businesses that can help with your search for Colon Cancer Treatment. You will find helpful, informative articles about Colon Cancer Treatment, including Colon Cancer. You will also find local businesses that provide the products or services that you are looking for. Please scroll down to find the local resources in Carson City, NV that will answer all of your questions about Colon Cancer Treatment.
Colon Cancer Treatment cost in India starts from USD 7000. Find affordable packages, best specialists, hospitals and patient experiences for Colon Cancer Treatment in India through Vaidam.
We believe this is the first case report of anunusual presentation of hypercalcemia due to sarcoidosis mimicking metastatic colon carcinoma. A 68 year old lady with a background history of pancolectomy and neoadjuvant chemotherapy for Duke C1 rectal carcinoma under surveillance, ulcerative colitis, type 2 diabetes mellitus presented to the clinic with hypercalcemia with low parathyroid hormone (PTH) and symptoms of tiredness. Her blood test showed Adj Ca of 2.8 mmol/l, PTH , 2.5 pmol/l, Vitamin D 18 mol/l, ALP 177 U/l. She was commenced on 800 IU of vitamin D, ordered for bone scan, 24 h urine calcium excretion ratio, myeloma screen. Her surveillance CT scan couple of months earlier was reported stable features. She had an acute medical admission with unsteadiness of gait, tiredness and nausea. The adjusted calcium level was reported as 3.6 mmol/l with suppressed PTH. She was resuscitated with intravenous fluids and bisphosphate infusion. A CT scan of abdomen, chest and pelvis was organised that ...
A patient with a metastatic colon carcinoma was treated by immunoadsorption (IA) therapy using heat-killed, formalin-stabilized protein A-containing Staphylococcus aureus Cowan I as the immunoadsorbent. The patient experienced both subjective and objective positive clinical response without undue morbidity. The patients response correlated well with laboratory findings of decreased concentrations of carcinoembryonic antigen (CEA), immunoglobulin G (IgG), immune complexes (IC) and histopathologic data. The patient underwent surgery following 15 IA treatments; she lived for eighteen months, post-treatment.
Colon cancer is one of the most frequent solid tumor and simultaneous diagnosis of primary colon cancer and liver metastases occurs in about one fourth of cases. The current knowledge on epigenetic signatures, especially those related to hydroxymethylation in primary cancer tissue, synchronous metastasis and blood circulating cells is lacking. This study aimed to investigate both methylcytosine (mCyt) and hydroxymethylcytosine (hmCyt) status in the DNA of individual patients from colon cancer tissue, synchronous liver metastases, and in cancer-free colon and liver tissues and leukocytes. Patients undergoing curative surgery (n=16) were enrolled and their laboratory and clinical history data collected. The contents of mCyt and hmCyt were determined by a liquid chromatography/mass spectrometry (LC/MS/MS) method in DNA extracted from primary colon cancer, synchronous hepatic metastatic tissues and homologous cancer-free tissues, i.e., colon and liver tissues as well as leukocytes. The mCyt and hmCyt
Researchers have identified a biomarker that predicts which stage II colon cancer patients may benefit from adjuvant chemotherapy.
TY - JOUR. T1 - Single-dose versus fractionated radioimmunotherapy of human colon carcinoma xenografts using 131I-labeled multivalent CC49 single-chain Fvs1. AU - Goel, A.. AU - Augustine, S.. AU - Baranowska-Kortylewicz, Janina. AU - Colcher, D.. AU - Booth, B. J M. AU - Pavlinkova, G.. AU - Tempero, M.. AU - Batra, Surinder Kumar. PY - 2001/2/12. Y1 - 2001/2/12. N2 - The prospects of radiolabeled antibodies in cancer detection and therapy remain promising. However, efforts to achieve cures, especially of solid tumors, with the systemic administration of radiolabeled monoclonal antibodies (MAbs) have met with limited success. Using genetic engineering techniques, MAbs have been tailored to improve the therapeutic index (tumor:normal tissue ratio) in clinical radioimmunotherapy. In the present study, we investigated the potential of tetravalent {[sc(Fv)2]2} and divalent [sc(FV)2] single chain Fvs of MAb CC49 for therapy in athymic mice bearing s.c. LS-174T human colon carcinoma xenografts. Mice ...
TY - JOUR. T1 - Completion of therapy by medicare patients with stage III colon cancer. AU - Dobie, Sharon A.. AU - Baldwin, Laura Mae. AU - Dominitz, Jason A.. AU - Matthews, Barbara. AU - Billingsley, Kevin. AU - Barlow, William. PY - 2006/5/3. Y1 - 2006/5/3. N2 - Background: Certain factors, such as race or age, are known to be associated with variation in initiation of adjuvant chemotherapy for stage III colon cancer, but little is known about what factors are associated with completion of adjuvant therapy. To determine whether predictors of initiation also predict completion, we analyzed Surveillance, Epidemiology, and End Results (SEER) program data linked to Medicare claims. We investigated mortality as a means to testing the validity of the completion measure that we created. Methods: We studied 3193 stage III colon cancer patients whose diagnosis was recorded in 1992-1996 SEER program data linked to 1991-1998 Medicare claims and who initiated adjuvant chemotherapy after colon cancer ...
Currently, data regarding the prognosis of right-sided versus left-sided colon cancer are conflicting, however, most studies revealed a poorer survival in right-sided primary tumor location [14-18, 29].. To our knowledge this is the first population-based, propensity score adjusted analysis investigating the prognostic impact of tumor location in non-metastatic colon cancer patients. Being aware of the conflicting data and also of the challenges to handle relevant bias due to substantial imbalances regarding baseline characteristics between right- and left-sided colon cancer patients, we have intentionally selected the propensity score matching as a further statistical method in addition to common multivariate analysis to minimize confounding. In the present analysis, the cohort was partitioned into subgroups containing one or more patients with right-sided colon cancer who were matched to one or more patients with left-sided colon cancer with similar values on the observed covariates in the ...
TY - JOUR. T1 - Identification of Endogenous Inhibitory Growth Factors from a Human Colon Carcinoma Cell Line. AU - Levine, Alan E.. AU - McRae, L. J.. AU - Hamilton, David A.. AU - Brattain, Diane E.. AU - Yeoman, Lynn C.. AU - Brattain, Michael G.. PY - 1985/5/1. Y1 - 1985/5/1. N2 - A line of human colon carcinoma cells, designated MOSER, was established which synthesized tumor-inhibitory factor (TIF) and transforming growth factor (TGF) activity. Both activities were found in serum-free conditioned medium and in cell extracts. The activities coelute on Bio-Gel P-10 in acetic acid, but can be completely separated by reverse-phase high-pressure liquid chromatography. The TIF and TGF activities were acid and heat stable and were sensitive to trypsin and dithiothreitol. MOSER cell TIF prevented the anchorage-independent growth of the more differentiated colon carcinoma cell lines tested but did not affect the less differentiated lines. Using anchorage-dependent growth conditions, the effect of ...
2018 American Association for Cancer Research. Unresectable hepatic metastases of colon cancer respond poorly to existing therapies and are a major cause of colon cancer lethality. In this study, we evaluated the therapeutic viability of targeting the mediator kinase CDK8, an early clinical stage drug target, as a means to suppress metastasis of colon cancer. CDK8 was amplified or overexpressed in many colon cancers and CDK8 expression correlated with shorter patient survival. Knockdown or inhibition of CDK8 had little effect on colon cancer cell growth but suppressed metastatic growth of mouse and human colon cancer cells in the liver. This effect was due in part to inhibition of already established hepatic metastases, indicating therapeutic potential of CDK8 inhibitors in the metastatic setting. In contrast, knockdown or inhibition of CDK8 had no significant effect on the growth of tumors implanted subcutaneously, intrasplenically, or orthotopically in the cecum. CDK8 mediated colon cancer ...
To understand colon cancer metastasis, we earlier analyzed a mouse model that developed liver metastasis of cancer cells disseminated from the spleen. We suggested that CCR1(+) bone marrow (BM)-derived cells are recruited to the microenvironment of disseminated colon cancer cells, and produce metall …
BACKGROUND: Circular RNAs (circRNAs) are considered to be highly stable due to the closed structure, which are predominately correlated with the development and progression of a wide variety of cancers. Colon cancer is one of the most common malignancies worldwide. A recent study demonstrated the upregulated expression of circPIP5K1A in non-small cell lung cancer. However, few studies have investigated the relationship between circ_0014130 level and colon cancer. Therefore, elucidating the underlying mechanisms of circPIP5K1As role may help with the identification of novel diagnostic and therapeutic targets for colon cancer. AIM: To investigate the status of circPIP5K1A in colon cancers and its effects on the modulation of cancer development. METHODS: The expression level of circPIP5K1A in tissue and serum samples from colon cancer patients, as well as human colonic cancer cell lines was detected by real-time quantitative reverse transcription-polymerase chain reaction. Following the ...
4334 Vascular endothelial growth factor (VEGF) has been shown to be associated with tumor angiogenesis and poor prognosis in human colon cancer. VEGF receptor-1 (VEGFR-1/Flt-1) is a high-affinity receptor for VEGF and is typically viewed as being endothelial cell specific. Here we report on the expression and function of VEGFR-1 on colon cancer cell lines. VEGFR-1 was expressed in 7/7 colon cancer cell lines as determined by Western blot analysis. Treatment of the human colon cancer cell line SW480 with VEGF-A (ligand for both VEGFR-1 and VEGFR-2) or VEGF-B (a ligand specific for VEGFR-1) led to activation of Erk 1/2. A blocking antibody to VEGFR-1 (18F1) completely inhibited the ability of VEGF-A and -B to activate Erk 1/2 in SW480 cells. VEGF-A and B did not increase colon cancer cell proliferation as determined by the MTT assay. However, VEGF-A and VEGF-B led to a significant induction of cancer cell motility and invasion through Matrigel. VEGF-A and -B stimulation of colon tumor cells also ...
Colon cancer treatments are varied and you can choose from a series of traditional and alternative methods of dealing with this condition. Surgery is often the number one choice - the surgeon removes the tumors on the colon, even if the cancer cells are spread beyond the colon itself. This ensures less problems in the future of the patients life, reducing chances of bowel problems or internal bleeding. Colon cancer surgery is usually categorized in four main areas: rectum resection, radio frequency ablation, colostomy and colon resection. The surgeon will determine which method is best suited for each individual patient ...
ORLANDO-Compared with the standard first-line chemotherapy treatment for advanced colorectal cancer, patients treated with the FOLFOX4 regimen containing the investigational agent oxaliplatin lived longer and had fewer side effects. 1
ORLANDO-Compared with the standard first-line chemotherapy treatment for advanced colorectal cancer, patients treated with the FOLFOX4 regimen containing the investigational agent oxaliplatin lived longer and had fewer side effects.
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
Colon cancer is the second leading cause of cancer death in men and women. New Hope Unlimiteds alternative colon cancer treatment consists of a non-invasive, less toxic and more effective treatment strategy that improves the symptoms and reverse the disease. Know your options and call us at 480-845-0813.
Find out more about Colorectal Cancer ( Colon Cancer ) Treatment in Spain. Costs, Treatments, and Prioritized Appointments with best Doctors at top JCI-Certified Hospitals
Background Cyclooxygenase-2 (COX-2) is a key factor in the development of colorectal cancer, and non-steroidal anti-inflammatory drugs (NSAIDs) have anti-colorectal cancer activity. However, the potential molecular mechanism of the COX-2 selective inhibitor effect on proliferation and apoptosis of colon cancer cells is unclear. In this study, we have demonstrated for the first time that the Delta1/Notch1 signal transduction pathway mediates the COX-2 selective inhibitor effect on colorectal cancer cells, and we reveal the mechanism of the Notch1 pathway in terms of regulating the proliferation and apoptosis of colorectal cancer cells. Methods and Result Colon cancer cell lines HT-29 and SW480 were treated with NS-398 (a COX-2 selective inhibitor) and DAPT (a gamma-secretase inhibitor). The colormetric MTT cell proliferation assay and flow cytometry were used to measure cell proliferation and apoptosis. Reverse transcriptase (RT)-PCR and ELISA analyses were used to detect the levels of COX-2 mRNA ...
TY - JOUR. T1 - RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells. AU - Subauste, M. Cecilia. AU - Ventura-Holman, T.. AU - Du, L.. AU - Subauste, Jose S.. AU - Chan, Shing Leng. AU - Yu, Victor C.. AU - Maher, Joseph F.. PY - 2009/12/1. Y1 - 2009/12/1. N2 - Evasion of apoptosis plays an important role in colon cancer progression. Following loss of the Apc tumor suppressor gene in mice, the gene encoding Fem1b is upregulated early in neoplastic intestinal epithelium. Fem1b is a pro-apoptotic protein that interacts with Fas, TNFR1 and apaf-1, and increased expression of Fem1b induces apoptosis of cancer cells. Fem1b is a homolog of FeM-1, a protein in Caenorhabditis elegans that is negatively regulated by ubiquitination and proteasomal degradation. To study Fem1b regulation in colon cancer progression, we used apoptotis-sensitive SW480 cells, derived from a primary colon cancer, and their isogenic, apoptosis-resistant counterparts sW620 cells, ...
BACKGROUND: Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells to endothelial cells. It requires interactions between adhesion receptors on endothelial cells and their counter-receptors on cancer cells. Notably, E-selectin, a major endothelial adhesion receptor, interacts with Death receptor-3 present on metastatic colon carcinoma cells. This interaction confers metastatic properties to colon cancer cells by promoting the adhesion of cancer cells to endothelial cells and triggering the activation of the pro-migratory p38 and pro-survival ERK pathways in the cancer cells. In the present study, we investigated further the mechanisms by which the E-selectin-activated pathways downstream of DR3 confer a survival advantage to colon cancer cells.. METHODS: Cell survival has been ascertained by using the WST-1 assay and by evaluating the activation of the PI3 kinase/NFκB survival axis. Apoptosis has been assayed by ...
Learn about Colon Cancer Treatment (Patient). Information from PDQ, the National Cancer Institutes comprehensive cancer information database.
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Cancer Monthly. Colon Cancer treatments. Chemotherapy. Monash University, Melbourne, Australia. Compare therapy differences, longest survival rates, toxicity, side effects, hospitals.
Cancer Monthly. Colon Cancer treatments. Chemotherapy. Universitat Aut noma de Barcelona, Barcelona, Spain. Compare therapy differences, longest survival rates, toxicity, side effects, hospitals.
It is pertinent however to determine wholesome cooking strategies in addition to consuming habits in methods to not intervene with the nutritious worth of meals Mother Nature intended. Have you ever ever gone through a grueling weight reduction program for a very long time, solely to seek out out later that youve hit a wall when it comes to outcomes. You wont end up tempted almost as much if your forbidden foods arent simply accessible. Correctly, chances are youll need to do additional than merely discovering a meals plan reply program. He did it greater than 50 years earlier. One factor to remember when deciding how one can go about shedding pounds is that there is no such thing as a single greatest way to lose weight. This can be a weight loss program thats loaded with numerous greens and fruits, chemopreventive effects of dietary canola oil on colon cancer development with the lean meats and likewise other protein sources. Due to this actuality, it is best to avoid excessive consumption ...
Among patients with Stage II or Stage III colon cancer, the Oncotype DX colon cancer test provides information about risk of cancer recurrence and may help guide treatment decisions. These results were presented at the 2012 Annual Meeting of the American Society of Clinical Oncology.. Gene expression profiling explores the patterns of genes that are active in tumor cells. Studies suggest that gene expression may provide important information about prognosis or likely response to treatment in several types of cancer. For example, among women with early-stage, estrogen receptor-positive breast cancer, the Oncotype DX breast cancer test has been shown to predict the likelihood of cancer recurrence and the likelihood of benefit from chemotherapy. As a result, the test has been added to medical guidelines for early-stage breast cancer.. A similar test became available for colon cancer patients in 2010. The test was originally developed for use in patients with Stage II colon cancer, but has now also ...
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Inflammation has a critical role in the pathogenesis and progression of cancer. Recently, the derived neutrophil to lymphocyte ratio (absolute count of neutrophils divided by the absolute white cell count minus the absolute count of neutrophils; dNLR) has been shown to influence clinical outcome in various cancer entities. In this study, we analysed the dNLR with clinical outcome in stage II and III colon cancer patients. Three-hundred and seventy-two patients with stage II and III colon cancer were included in this retrospective study. Kaplan-Meier curves and multivariate Cox proportion analyses were calculated for time to recurrence (TTR) and overall survival (OS). In univariate analysis, the elevated preoperative dNLR was significantly associated with decreased TTR (hazard ratio (HR) 2.38, 95% confidence interval (CI) 1.57-3.6, P|0.001) and remained significant in multivariate analysis. Patients with dNLR |3 had a median TTR of 83 months, and patients with dNLR ⩽3 showed a median TTR of 132 months.
Before talking about colon cancer prevention, lets talk a little about what colon cancer is, exactly. Both the colon and rectum are part of the digestive system. The first part of the digestive system, which is the esophagus and stomach, breaks down food to be processed into energy. Next, the broken down food travels to the small intestine/bowel, which is a narrow, 20-foot section that continues breaking down food and absorbing most of the nutrients. The small intestine then sends the remaining material to the five-foot-long colon (which is also referred to as the large intestine), where it absorbs salt and water and stores waste. The first part of the colon is the ascending colon, which is attached to the small intestine and the appendix on the right side of the abdomen. The transverse colon runs from the right to the left side of the upper abdomen. The descending colon travels downward on the left side and the sigmoid colon is an S-shaped portion that passes food matter down to the rectum, ...
We previously reported that CIN85, an 85 KDa protein known to be involved in tumor cell migration and metastasis through its interaction with Cbl, associates with MUC1 in tumor cells. MUC1/CIN85 complex also regulates migration and invasion of tumor cells in vitro. Here, we examined specifically human colon carcinoma tissue microarrays (TMA) by immunohistochemistry for the expression of MUC1 and CIN85 and their potential role in cancer progression and metastasis. We detected a significant increase in expression of both MUC1 and CIN85 associated with advanced tumor stage and lymph node metastasis. We further investigated if Cbl could also be present in the MUC1/CIN85 complex. Co-immunoprecipitation assay showed that Cbl co-localized both with CIN85 and with MUC1 in a human colon cancer cell line. To begin to investigate the in vivo relevance of MUC1 overexpression and association with CIN85 and Cbl in cancer development and progression, we used human MUC1 transgenic mice that express MUC1 on the colonic
denotes superscript. Background: This study was conducted to develop a non-invasive orthotopic model for metastasis of colon and rectal cancer using a trans-anal approach that is non-operative, reproducible, and easy to perform. Currently, the most accurate orthotopic representation of metastatic human colon cancer is a cecal injection. The trans-anal model allows for further examination of systemic immune responses, tumor take, and onset of metastasis without prior surgical intervention.. Methods: Sixty (60) Balb/c mice were anesthetized and received gentle anal dilation using blunt tipped forceps at the anal opening. Using a 29 gauge syringe, murine colon cancer parental CT26 (CT26) or luciferase labeled CT26 (CT26-luc) cells were injected submucosally into the distal, posterior rectum (CT26 N=30 and CT26-luc N=30) at various concentrations: 2.5×10(^4), 1×10(^5), or 1×10(^6) in a volume of 50µL. All mice were injected using 100 x magnification. Tumor growth and metastatic development was ...
Background: Mucin, a family of high molecular weight glycoprotein has been implicated in a variety of cancers. MUC13 is a newly identified transmembrane mucin which has shown deregulated expression in gastric and ovarian cancers. However, limited information is available about the role of MUC13 in colon cancer progression. The present study investigated the expression profile, clinical relevance and functional significance of MUC13 expression in colon cancer progression.. Materials and Methods: The MUC13 expression profile was determined by immunohistochemical (IHC) analysis using a novel MUC13 monoclonal antibody (PPZ0020) on a panel of colon cancer tissue microarrays containing non-malignant, colon cancer and liver metastasis tissue samples. Colon cancer cell lines which showed faint (SW480) and high (SW620) MUC13 expression were selected for over-expression and knockdown experiments, respectively, to determine the functional role of MUC13 in colon cancer progression. Functional studies, such ...
Todays guest is Wade Hayes, country singer and advanced colon cancer survivor. He is here with us to help support awareness in colon cancer during Colon Cancer Awareness Month in March—a disease impacting nearly 93,000 people this year. Wade was at the height of his country music career with Billboard hits and a promising road ahead when he was diagnosed with stage IV colon cancer. Like so many people facing a cancer diagnosis, he had to put his life on hold. After successful treatment, the singer is determined to reignite his career. Wade is in NYC launching his brand new album and song ?Go Live Your Life?—an emotional song that he wrote after his oncologist told him he was cancer free. For every download of ?Go Live Your Life? purchased on iTunes, a donation of a $1 will be made to the Colon Cancer Alliance Blue Note Fund, a non-profit that supports colon cancer patients who are currently in treatment. Please go visit the site at www.goliveyourlife.com.
TY - JOUR. T1 - Oncogenic K-RAS is required to maintain changes in cytoskeletal organization, adhesion, and motility in colon cancer cells. AU - Pollock, Claire B.. AU - Shirasawa, Senji. AU - Sasazuki, Takehiko. AU - Kolch, Walter. AU - Dhillon, Amardeep S.. PY - 2005/2/15. Y1 - 2005/2/15. N2 - RAS oncegenes are thought to play a role at multiple stages of tumorigenesis. The role and mechanisms by which RAS oncogenes maintain the transformed state of human cancer cells are poorly understood. Here, we have studied the role of oncogenic K-RAS in maintaining cytoskeletal disruption, cell adhesion and motility in metastatic colon carcinoma cells. Targeted deletion of K-RASG13D from HCT116 colon carcinoma cells restored their ability to assemble stress fibers and focal adhesions/complexes, accompanied by increased cell-matrix adhesion and reduced motility. We further show that oncogenic K-Ras induces high Rho activity, but uncouples Rho from stress fiber formation. This uncoupling required the ...
Binding studies with 125I-Tyr labelled hyaluronan (HA) on a cultured rat colon cancer cell line were performed to characterize the association of HA to tumour cells in vitro. Results show a specific and saturable binding (Kd=1.36 nM) which indicates the presence of an HA binding receptor on the tumour cells. There is a specific constant increase of cell-associated HA over time, which indicates that HA is specifically taken up by the cells through endocytosis. The binding of 125I-Tyr labelled HA was more effectively inhibited by unlabelled HA of high MW in relation to low MW species of the polysaccharide indicating that the receptor binds HA of high MW with greater affinity than low MW species. In competition experiments, the HA-binding could not be inhibited by other polysaccharides such as chondroitin sulphate and heparin. Nor could ligands for scavenger receptors and antibodies directed towards ICAM-1, CD 44 and RHAMM (Receptor for HA Mediated Motility) significantly inhibit the association of ...
TY - JOUR. T1 - PTH-related protein enhances LoVo colon cancer cell proliferation, adhesion, and integrin expression. AU - Shen, Xiaoli. AU - Falzon, Miriam. PY - 2005/2/15. Y1 - 2005/2/15. N2 - Parathyroid hormone-related protein (PTHrP) has been localized in human colon cancer tissue and cell lines. Tumor cell adhesion to extracellular matrix (ECM) proteins plays a major role in the invasion and metastasis of tumor cells, and is mediated via integrin subunits. The LoVo human colon cancer cell line was used as a model system to study the effects of PTHrP on cell proliferation and adhesion to ECM proteins found in normal liver. Clones of LoVo cells engineered to overexpress PTHrP by stable transfection with a PTHrP cDNA showed enhanced cell proliferation vs. control (empty vector-transfected) cells. PTHrP-overexpressing cells also showed significantly higher adhesion to collagen type I, fibronectin, and laminin, and enhanced expression of the ∀2, ∀5, ∀6, ∃1 and ∃4 integrin subunits. ...
TY - JOUR. T1 - Modified complete mesocolic excision with central vascular ligation for the treatment of right-sided colon cancer. T2 - Long-term outcomes and prognostic factors. AU - Cho, Min Soo. AU - Baek, Se Jin. AU - Hur, Hyuk. AU - Min, Byung Soh. AU - Baik, Seung Hyuk. AU - Kim, Namkyu. PY - 2015/4/1. Y1 - 2015/4/1. N2 - Objective: to Investigate the Long-term Oncologic Outcomes and Risk Factors for Adverse Effects in Rt.-sided Colon Cancer Patients Who Underwent Modified Complete Mesocolic Excision . Background: Complete Mesocolic Excision with Ctrl. Vasc. Ligation Has Recently Been Found to Improve Oncological Outcomes in Patients with Colon Cancer. Our Inst. Has Estab. MCME on the Basis of the Original Concept of CME for the Treatm. of Rt.-sided Colon Cancer. Methods: between January 2000 and July 2009, 773 Patients Who Underwent MCME for Rt.-sided Colon Cancer Were Eligible for This Retrospective Stud.. the Prognostic Factors for Survival/recurrence and the Risk Factors for ...
TY - JOUR. T1 - Modulation of chemosensitivity in human colon carcinoma cells by downregulating Protein Kinase Cα expression. AU - Chakrabarty, Subhas. AU - Huang, Shuang. PY - 1996/7/1. Y1 - 1996/7/1. N2 - Protein kinase C (PKC) is thought to play a role in tumor progression and drug resistance of colon carcinomas. Specifically, the PKCα isoform has been implicated in drug resistance and responsiveness of colon carcinoma cells to growth factors. Therefore, in this study we determined the effect of downregulating PKCα expression by transfecting human colon carcinoma cells with an antisense PKCα expression vector and then determined the sensitivity of these cells to the anticancer drugs mitomycin C (MMC), 5-fluorouracil (5-FU) and vincristine (Vin). Transiently transfecting the human colon carcinoma cell lines Moser, SW480 and HT29 with antisense PKCα expression vector (but not antisense PKCβ expression vector) consistently increased the sensitivity of these cells to MMC, 5-FU and VIN by ...
Cell lines are invaluable tools for biomedical research. Cancer cell lines are the foundation of cancer biology and the quest for drug treatments. Adenocarcinoma is a cancer of the epithelium (including colon) and originates in glandular tissue, such as skin surface layer and glands.. Product. These human adenocarcinoma cell lines have been previously licensed to commercial parties for research into human adenocarcinoma treatments.. These cell lines are available through Public Health England ECACC. Please make your purchase through the links below.. Imperial Innovations requests that commercial/for profit parties contact them first to discuss the terms of supply prior to Innovations authorising the release of supplies from ECACC.. ...
The aim of this study was to analyze the molecular mechanism of inositol hexaphosphate (InsP6) action through which it may inhibit proliferation of colon cancer cells and cell cycle progression. A kinetic study of p53 and p21WAF1 mRNA increase was performed on human colon cancer HT-29 cells after treatment with 1, 5 and 10 mM InsP6 for 6, 12, 24 and 48 h. Real-time-QPCR based on TaqMan methodology was applied to analyze quantitatively the transcript levels of these genes. The transcription of β-actin and GAPDH genes was assessed in parallel to select the control gene with least variability. The 2-ΔΔCt method was used to analyze the relative changes in gene transcription. InsP6 stimulated p53 and p21WAF1 expression at the mRNA level, with the highest increase in p21WAF1 mRNA occurring at 24 h, i.e., following the highest increase in p53 mRNA observed at 12 h. Based on these studies it may be concluded that the ability of InsP6 to arrest the cell cycle may be mediated by the transcriptional ...
Human Colon Cancer Stem Cell Culture Extra-cellular Differentiation Matrix is essential for Differentiation of Human Colon Cancer Stem Cell Cultures. This product requires Human Colon Cancer Stem Cell Culture Media Cat#M36112-39 and Cells Cat# 36112-39. Also available Products ...
HPB Surgery is a peer-reviewed, Open Access journal that offers ready access to important developments in the field of HPB surgery and associated disciplines. We aim to publish fresh experimental and clinical work across the spectrum of HPB disease, while concentrating on those conditions for which surgical treatment - not necessarily an actual operation - is a common option. Thus diabetes mellitus and hepatitis, for example, might belong more appropriately elsewhere, though not if the paper should concern pancreatic transplantation or virally-induced hepatoma.
Mutations in apc which lead to activation of the Wnt signaling pathway are a hallmark of sporadic colon cancers but occur infrequently in colon cancers arising in patients with inflammatory bowel disease (IBD). There is evidence, however, that other components of the Wnt pathway may be altered in IBD-related colon cancer. In this study, we examined the expression the Wnt pathway components frizzled (Fz), the cell surface receptor, and disheveled (DVL), a family of cytoplasmic signal transduction molecules, in IBD and IBD-related colon cancer. Paraffin sections of normal and malignant colon tissues were obtained from patients with a history of ulcerative colitis and from controls with sporadic colon cancer. Tissue sections were stained with antibodies directed against Fz1/2 receptors and DVL1, DVL2 and DVL3 and antigen expression visualized by immunohistochemistry. Fz1/2 receptors were minimally expressed in normal IBD mucosa, were not expressed in IBD colon cancer, but exhibited strong ...
Contluent cultures of Caco-2 cells, a human colonic carcinoma cell line, undergo differentiation into enterocyte-like cells and are widely used as a model system to study the expression of membrane peptidases on the apical brush border [I-41 Indirect irnniunofluorescent staining has previously shown dipeptidylpeptidase IV (DPPIV, EC 3 4 14 5) to be homogeneously distributed on the surface of Caco-2 cells [ I ] whereas endopeptidase-24 1 1 (E-24 I I , EC 3 4 24 I I ) was found on the surface of some cells but not on others [4] This observation has also been reported by Jalal e/ d. [ S ] who have shown that E-24 1 1 is expressed by all cells but in some is confined to an intracellular pool In the present study the cellsurface and intracellular expression of five membrane peptidases on confluent cultures of Caco-2 cells has been investigated using indirect immunofluorescent staining The membrane peptidases studied were DPPIV, E-24 I I , angiotensin converting enzyme (ACE, EC 3 4 15 I). ...
Anticancer Effect of COX-2 Inhibitor DuP-697 Alone and in Combination with Tyrosine Kinase Inhibitor (E7080) on Colon Cancer Cell Lines Colon cancer;DuP-697;COX-2 inhibition;tyrosine kinase inhibitor; Colorectal cancer remains one of the most common types of cancer and a leading cause of cancer death worldwide. In this study, we aimed to investigate effects of DuP-697, an irreversible selective inhibitor of COX-2 on colorectal cancer cells alone and in combination with a promising new multi-targeted kinase inhibitor E7080. The HT29 colorectal cancer cell line was used. Real time cell analysis (xCELLigence system) was conducted to determine effects on colorectal cell proliferation, angiogenesis was assessed with a chorioallantoic membrane model and apoptosis was determined with annexin V staining. We found that DuP-697 alone exerted antiproliferative, antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. For the antiproliferative effect the half maximum inhibition concentration ($IC_{50
TY - JOUR. T1 - Overexpression of ras in mucus-secreting human colon carcinoma cells of low tumorigenicity. AU - Augenlicht, Leonard H.. AU - Augeron, C.. AU - Yander, G.. AU - Laboisse, C.. PY - 1987. Y1 - 1987. N2 - We have investigated the expression of the protooncogenes of the myc and ras family in HT29 cells and in three different clonal cell lines derived from this colon carcinoma cell line. In contrast to the decrease in myc expression seen when leukemia cells are induced to differentiate, we have found no changes in expression of the myc gene family in differentiated colon carcinoma cells. However, a greater than 5-fold increase in expression of sequences which hybridize to Ha-ras was observed in cells which secrete mucin, with a smaller increase seen in expression of Ki-ras in the same cells. This increase was not seen in cells which exhibit vectorial transport of water and ions, and which are not mucus-secreting. All differentiated lines were less tumorigenic in nude mice than the ...
With very few exceptions, initial therapy for colon cancer is adequate surgical resection. Subsequent surgical and pathologic staging will dictate the need for adjuvant therapy. Currently, Stage I colon cancer patients enjoy a high cure rate after surgery alone (,80%), and there is no evidence that these patients will benefit from any adjuvant therapy. Large randomized clinical trials have been more interested in Stage II and Stage III colon cancer patients whose cure rate can be as low as 30% after surgery alone. Early chemotherapy trials for colon cancer used the chemotherapeutic agents available at the time. Eventually, fluorinated pyrimidines (5-Fluorouracil or 5-FU) were shown to have activity against metastatic colorectal cancer. This finding led to several trials evaluating 5-FU as adjuvant therapy for high risk patients after surgery (Stage II and III colon cancer). In 1988, Buyse and colleagues(4) published a meta-analysis of all randomized controlled trials of adjuvant therapy with ...
This study showed that greater weight, waist, and WHR before diagnosis (at baseline) were risk factors for all-cause mortality for women diagnosed with colon cancer. These associations were independent of age at diagnosis, education, smoking, and stage. The HR of all-cause mortality was also increased among those in the obese BMI category and among those few women in the underweight BMI category compared with women of normal weight. This pattern is similar to the relationship between BMI and all-cause mortality among all IWHS women (7, 20).. There were also statistically significant positive associations of colon cancer mortality with waist circumference and WHR. Women in the highest tertiles of waist and WHR had a 30% to 40% greater colon cancer mortality (similar to all-cause mortality) compared with the lowest tertiles. However, BMI and weight were not significantly associated with colon cancer mortality. Thus, WHR, which reflects abdominal obesity, and waist circumference, which ...
Youve probably talked to your kids about important issues like time management and personal finances, but have you ever talked to your kids about colon cancer? Contrary to what most people think, colon cancer is not just a disease for the elderly. In fact, young-onset colon cancer incidence is increasing in individuals under the age of 50. If youve never had the conversation with your kids about colon cancer prevention and awareness, now is the time.. Its very likely that you may not know how or when to bring up the subject, or even what to say. After all, colon cancer and colonoscopies are not exactly dinner table conversation. We couldnt agree more, so choose a setting that is comfortable for everyone. You could consider a family walk, a cup of coffee at the kitchen table, or a trip to your local park.. Once youve chosen the setting, you need to think of how you will present your message. Remember, your goal is to inform and encourage. It might help to begin with a few facts to inform ...
Combining different chemopreventive agents is a promising strategy to reduce cancer incidence and mortality due to potential synergistic interactions between these agents. Previously, we demonstrated that oral administration of nobiletin (NBT, a citrus flavonoid) at 0.05% (w/w, in diet) together with atorvas
In this Danish national register-based cohort study, we examined the effects of alendronate on the development of colon cancers and survival. The incidence of colon cancer and mortality rate, once colon cancer had been diagnosed, were lower in patients treated with alendronate, posing the question whether alendronate acts as chemopreventive.When bisphosphonates are given by mouth, around 99% remains non-absorbed in the intestine. Based on their biochemical actions, we predicted that oral bisphosphonates might prevent colon cancers.This is a Danish national register-based cohort study. We identified 30,606 women aged 50+, mean age 71.9 years, who had not previously taken treatments for osteoporosis, who began to take alendronate in 1996-2005, and assigned 124,424 individually age- and gender-matched control subjects. The main outcome measure was colorectal cancers incidence and post-diagnosis survival in patients taking oral alendronate for osteoporosis.Cox proportional hazards analysis of death due to
Could preventing colon cancer be as simple as developing a taste for yerba mate tea? In a recent University of Illinois study, scientists showed that human colon cancer cells die when they are exposed to the approximate number of bioactive compounds present in one cup of this brew, which has long been consumed in South America for its medicinal properties. The caffeine derivatives in mate tea not only induced death in human colon cancer cells, they also reduced important markers of inflammation, said Dr. Elvira de Mejia, a University of Illinois associate professor of food chemistry and food toxicology. Thats important because inflammation can trigger the steps of cancer progression, she said. In the in vitro study, Dr. de Mejia and former graduate student Sirima Puangpraphant isolated, purified, and then treated human colon cancer cells with caffeoylquinic acid (CQA) derivatives from mate tea. As the scientists increased the CQA concentration, cancer cells died as a result of apoptosis. Put ...
Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we critically present the molecular, cellular, histopathological, and chemopreventive evidence that ACF are relevant biomarkers for colon cancer. The laboratory and clinical evidence are highly suggestive that ACF are in the pathway leading to colon cancer, but not all ACF will do so. The possible fate and outcome of ACF in the progression toward colon cancer may be dependent on a number of features that define their predictive power for the prevention or progression of cancer.
Background We assessed the novel MACC1 gene to further stratify stage II colon cancer patients with proficient mismatch repair (pMMR). Patients and methods Four cohorts with 596 patients were analyzed: Charité 1 discovery cohort was assayed for MACC1 mRNA expression and MMR in cryo-preserved tumors. Charité 2 comparison cohort was used to translate MACC1 qRT-PCR analyses to FFPE samples. In the BIOGRID 1 training cohort MACC1 mRNA levels were related to MACC1 protein levels from immunohistochemistry in FFPE sections; also analyzed for MMR. Chemotherapy-naïve pMMR patients were stratified by MACC1 mRNA and protein expression to establish risk groups based on recurrence-free survival (RFS). Risk stratification from BIOGRID 1 was confirmed in the BIOGRID 2 validation cohort. Pooled BIOGRID datasets produced a best effect-size estimate. Results In BIOGRID 1, using qRT-PCR and immunohistochemistry for MACC1 detection, pMMR/MACC1-low patients had a lower recurrence probability versus pMMR/MACC1-high
Colorectal cancer is the second leading cause of cancer-related death in the United States. Among many gene mutations associated with colorectal cancer, mutation of APC (adenomatous polyposis coli) or ß-catenin, which activates Wnt signaling, represents the initiation step of colon tumorigenesis. Wnt signaling is known to play multiple roles in early development and formation of human cancers. In addition, Wnt signaling also regulates the self-renewal and differentiation of adult stem cells. Recently, cancer stem cells have emerged as an exciting new concept in cancer research. This book discusses the development and trends in the field of cancer stem cell research, with emphasis on colon cancer stem cells. (Imprint: Nova Biomedical). ...
CRC is the third most common cancer in men and women and is the third leading cause of cancer death (39, 40). Thus, the causes and methods of preventing and treating colon cancer are a high priority. In particular, abnormal activation of Wnt signaling has been tightly linked to colon cancer. Therefore, identifying small molecules targeting Wnt signaling is a promising preventive or treatment strategy against cancer.. In the current study, we identified a natural product, esculetin, as a potent inhibitor of Wnt signaling. Previously, the inhibitory effect of esculetin on cell proliferation in many cell lines has been reported (32, 33, 43, 44). However, the molecular mechanism of the antiproliferation effect of esculetin against colon cancer cells is not clearly understood. In the present study, we demonstrated that esculetin could disrupt the interaction between β-catenin and Tcf by targeting β-catenin, leading to suppression of the proliferation of three different colon cancer cell lines ...
Scientists have developed a novel biomarker that could help predict a persons risk of developing colon cancer at the University of Cincinnati. Hotspots has been identified which play a critical role in regulating gene expression and influence colon cancer progression. Researchers consider that these hotspots could be used as a biomarker for colon cancer. AMACR is the first study to explain how a gene is regulated in relation to cancer development and to identify specific genetic events (a polymorphism and somatic cell mutations) related to colon cancer. UC researchers looked at the actions of the AMACR gene in human tissue in this study. AMACR breaks down branched-chain fatty acids, a type of molecule only found in animals that eat plants. Previous research showed that plant-derived fatty acids, such as those found in red meat and dairy products, can accelerate cancer growth. AMACR genes abnormal expression patterns using a sophisticated laser-capture microdissection technique identifies the ...
A molecular ribbon model of estrogen receptor beta, a protein encoded by the ESR2 gene, found primarily in the kidneys, brain, bone, heart, lungs, intestinal mucosa, prostate and endothelial cells. After activated by estrogen hormones, estrogen receptors bind to DNA to regulate gene expression. Abnormal activity by estrogen receptors have been observed in cases of breast cancer, ovarian cancer, colon cancer, prostate cancer and endometrial cancer. The loss of estrogen receptor beta proteins can disrupt the process of apoptosis and are often associated with advanced colon cancer and the development of tumours. - Stock Image C027/6387
The mRNA as well as protein expression of SASH1 was strongly and significantly reduced in colon cancer of UICC stage II, III, and IV, as well as in colorectal liver metastases. In contrast, SASH1 expression was not significantly altered in benign adenomas and in early stage lesions (UICC I). Around 40% of primary colon tumours tested (n=113) showed a 10-fold or stronger reduction in SASH1 expression, compared to normal colon mucosa. Decreased SASH1 mRNA expression was correlated with the occurrence of metachronous distant metastasis, and multivariate analysis identified SASH1 downregulation as an independent negative prognostic parameter for patient survival (Rimkus et al., 2006). Recently, these results were confirmed on an independent patient collective of stage II colon cancer (n=179 patients), confirming that decreased SASH1 expression is an independent negative prognostic factor in colon cancer, allowing to distinguish high-risk patients in early, locally restriced stages of the disease ...
MicroRNAs (miRNAs or miRs) are short non-coding RNAs that affect the expression of genes involved in normal physiology, but that also become dysregulated in cancer development. In the latter context, studies to date have focused on high-abundance miRNAs and their targets. We hypothesized that among the pool of low-abundance miRNAs are some with the potential to impact crucial oncogenic signaling networks in colon cancer. Unbiased screening of over 650 miRNAs identified miR-206, a low-abundance miRNA, as the most significantly altered miRNA in carcinogen-induced rat colon tumors. Computational modeling highlighted the stem-cell marker Krüppel-like factor 4 (KLF4) as a potential target of miR-206. In a panel of primary human colon cancers, target validation at the mRNA and protein level confirmed a significant inverse relationship between miR-206 and KLF4, which was further supported by miR-206 knockdown and ectopic upregulation in human colon cancer cells. Forced expression of miR-206 resulted in
Background Only between 25 to 35% of stage II and IIIA colon cancer patients will experience a relapse of their disease and may benefit from adjuvant chemotherapy. ColoPrint is a gene expression classifier that can predict disease relapse in patients with early-stage colorectal cancer and helps to identify patients with higher risk of relapse.. Methods ColoPrint was developed using whole genome expression data and was validated in public datasets and an independent patient cohort of 206 patients (Salazar et al., JCO 2011). The signature was translated to a customized 8-pack microarray. Positive and negative hybridization control genes monitor the quality of hybridization and a colon specific normalization gene set (n = 461) guarantee reliability of results. Reproducibility and precision studies with 20 times 6 samples were performed by multiple operators on multiple days. Additional independent patient cohorts were validated on the customized arrays. Uni- and multi-variate analyses were ...
Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States. During the tumorigenesis and metastasis of CRC, cells encounter numerous cellular and molecular events. ATF3, a member of the ATF/CREB transcription factor family, plays an important role on regulation of apoptosis and is regarded as a potential molecular target for chemoprevention and chemotherapy of colon cancer. The current study was performed to investigate cellular and molecular mechanisms by which ATF3 affects colon cancer-related phenotypes including apoptosis and metastasis. Here, we demonstrated that knockdown of ATF3 using small interfering RNA (siRNA) promotes the expression of anti-apoptotic protein, B-cell lymphoma 2 (Bcl-2), in colon cancer cells, while overexpression of ATF3 resulted in a dramatic decrease in Bcl-2 protein. Gain of function of ATF3 in colon cancer cell line HCT116 led to an increase of pro-apoptotic protein Bcl-2 homologous antagonist killer (Bak), followed by the ...
Colorectal carcinoma growth and progression is dependent on the vasculature of the tumor microenvironment. Tumor-derived endothelial cells differ functionally from their normal counterpart. For this reason we isolated microvascular endothelial cells from human colon cancer tissue (HCTEC) and compared them with endothelial cells from normal colonic tissue (HCMEC) of the same donor. Since hypoxia is a universal hallmark of carcinomas, we examined its effects on HCTEC of five patients in comparison with the corresponding HCMEC, with respect to the secretion of the soluble form of the two important vascular endothelial growth factor (VEGF) receptors, VEGFR-1 and -2. After dissociation by dispase/collagenase of central non-necrotic tumor areas obtained from colon carcinomas, HCTEC were isolated using CD31-coated magnetic beads and cultivated as monolayers. Subsequent characterization studies demonstrated the endothelial phenotype, including VEGFR-1 and -2 mRNA and protein expression as well as E-selectin
Mice and reagents. Six- to eight-week-old female C57BL/6J and BALB/c mice were purchased from the Charles River Laboratory. OT-I mice and Ifnar-/- mice were obtained from Jackson Laboratory. All the mice were maintained under specific pathogen-free conditions.. The B16 (C57BL/6 mouse melanoma), LSV174T (human colon adenocarcinoma), CT26 (BALB/c mouse colon adenocarcinoma), and HEK293 cell lines were obtained from ATCC. MC38 (C57BL/6 mouse colon adenocarcinoma) was provided by Yang Xuanming (Shanghai Jiaotong University, Shanghai, China). B16-OVA cells were constructed by stably expressing OVA cDNA on B16 cells. PDAC murine pancreatic cancer cells were derived from spontaneous pancreatic cancer tissues of K-ras(G12D); p53-/- mice (51). DC2.4, a murine DC line, was provided by Kenneth Dock (University of Massachusetts Medical School, Worcester, Massachusetts, USA). B3Z hybridoma cells were provided by Nilabh Shastri (University of California, Berkeley, Berkeley, California, USA). All cell lines ...
Lipid metabolism plays an essential role in carcinogenesis due to the requirements of tumoral cells to sustain increased structural, energetic and biosynthetic precursor demands for cell proliferation. We investigated the association between expression of lipid metabolism-related genes and clinical outcome in intermediate-stage colon cancer patients with the aim of identifying a metabolic profile associated with greater malignancy and increased risk of relapse. Expression profile of 70 lipid metabolismrelated genes was determined in 77 patients with stage II colon cancer. Cox regression analyses using c-index methodology was applied to identify a metabolic-related signature associated to prognosis. The metabolic signature was further confirmed in two independent validation sets of 120 patients and additionally, in a group of 264 patients from a public database. The combined analysis of these 4 genes, ABCA1, ACSL1, AGPAT1 and SCD, constitutes a metabolic-signature (ColoLipidGene) able to ...
Ursolic acid (UA), a natural pentacyclic triterpenoid carboxylic acid distributed in medical herbs, exerts antitumor effects and is emerging as a promising compound for cancer prevention and therapy, but its excise mechanisms of action in colon cancer cells remains largely unknown. Here, we identified the molecular mechanisms by which UA inhibited cell proliferation and induced apoptosis in human colon cancer SW480 and LoVo cells. Treatment with UA led to significant inhibitions in cell viability and clone formation and changes in cell morphology and spreading. UA also suppressed colon cancer cell migration by inhibiting MMP9 and upregulating CDH1 expression. Further studies showed that UA inhibited the phosphorylation of Akt and ERK proteins. Pretreatment with an Akt or ERK-specific inhibitor considerably abrogated the proliferation inhibition by UA. UA also significantly inhibited colon cancer cell COX-2 expression and PGE2 production. Pretreatment with a COX-2 inhibitor (celecoxib) abrogated ...
Colon cancer affects one in 20 Americans, making it the third-leading cause of cancer death in the United States. Most cases of colon cancer are preventable through routine colonoscopy, but one out of every three Americans is not up to date on their colon screenings.. Although colon cancer rates are decreasing among men and women who are 50 and older, colon cancer incidence is steadily increasing among younger Americans. For this reason, the American Cancer Society recommends that men and women who are at average risk for colon cancer begin preventative screenings at age 45.. A colonoscopy is a life-saving procedure, so it is important to make an educated decision when selecting your gastroenterologist. Here are some guidelines to help you choose the best GI doctor in your area:. ...
Colon cancer affects one in 20 Americans, making it the third-leading cause of cancer death in the United States. Most cases of colon cancer are preventable through routine colonoscopy, but one out of every three Americans is not up to date on their colon screenings.. Although colon cancer rates are decreasing among men and women who are 50 and older, colon cancer incidence is steadily increasing among younger Americans. For this reason, the American Cancer Society recommends that men and women who are at average risk for colon cancer begin preventative screenings at age 45.. A colonoscopy is a life-saving procedure, so it is important to make an educated decision when selecting your gastroenterologist. Here are some guidelines to help you choose the best GI doctor in your area:. ...
Human (Parental) Colon Cancer Stem Cell (Plated cells are also available). 120 Population doublings up to 12 passages. One million viable cells upon thawing of frozen cells, frozen vial of cells shipped in dry-ice. Cell Cultures from single donors, 1000 different cell cultures available, please indicate which lots you require from the 1000 donors. Source: Human (Parental) Colon Cancer tissue. Positive Markers: Vimentin, Variable S100, CEA, Galactosyl Transferase II, CK-7, CK-20, Smooth Muscle Actin (polyp), Bcl2, Ki-67, P504S, Mucin (MUC-1 & MUC-3) For non-academic use please inquire for pricing. Cells are only guaranteed with purchase of Creative Bioarray Media and Creative Bioarray Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment ...
A new study finds daily aspirin can lower colon cancer risk, but some doctors warn against regular aspirin use because of possible side effects.. March is Colon Cancer Awareness Month, a time to raise awareness about colon cancer and take steps toward prevention. Colon cancer is the third-leading cause of cancer death in the United States, but most cases are preventable with regular colonoscopies and screenings. Preventing colon cancer is always less expensive than treating the disease, so researchers are continually performing studies to test new methods of prevention.. Through a recent study conducted at City of Hope Hospital in Duarte, California, Ajay Goel, Ph.D., M.S., discovered aspirin can prevent colon tumors from returning and even from forming. Goel and his research team used mice and mathematical modeling to mimic the different amounts of aspirin people in Europe and the United States take daily.. The researchers gave three different aspirin doses to mice that had four different colon ...
Lipkin M, Deschner E, Troncale F (1970). "Cell differentiation and the development of colonic neoplasms". CA: A Cancer Journal ... "Biochemical measure of the volume doubling time of human pulmonary neoplasms". Cancer. 55 (7): 1530-5. doi:10.1002/1097-0142( ...
Bitterness and Colonic Neoplasms". Digestive Diseases and Sciences. 50 (3): 483-9. doi:10.1007/s10620-005-2462-7. PMID 15810630 ...
... violet is absorbed into intestinal and neoplastic cells and is used to identify Barrett's esophagus and colonic neoplasms. ... characterization of colonic polyps and colorectal cancer, and in screening for dysplasia in individuals with ulcerative colitis ...
... colonic neoplasms MeSH C04.588.274.476.411.307.180.089 - adenomatous polyposis coli MeSH C04.588.274.476.411.307.180.089.500 - ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588.274.120.250.250 - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ... femoral neoplasms MeSH C04.588.149.721 - skull neoplasms MeSH C04.588.149.721.450 - jaw neoplasms MeSH C04.588.149.721.450.583 ...
... appendiceal neoplasms MeSH C06.301.371.411.307 - colorectal neoplasms MeSH C06.301.371.411.307.180 - colonic neoplasms MeSH ... appendiceal neoplasms MeSH C06.405.249.411.307 - colorectal neoplasms MeSH C06.405.249.411.307.180 - colonic neoplasms MeSH ... appendiceal neoplasms MeSH C06.405.469.491.307 - colorectal neoplasms MeSH C06.405.469.491.307.180 - colonic neoplasms MeSH ... cecal neoplasms MeSH C06.405.469.110.417.290 - appendiceal neoplasms MeSH C06.405.469.158 - colonic diseases MeSH C06.405. ...
... compared to histologically normal tissue from individuals who never had a colonic neoplasm. This finding suggests that ... MBD4 expression is reduced in almost all colorectal neoplasms due to methylation of the promoter region of MBD4. Also MBD4 is ...
Neoplasms / cancer Diverticulitis / Diverticulosis Hernias Inflammatory bowel disease Colonic volvulus (sigmoid, caecal, ... sutures Pseudoobstruction Hernias containing bowel Crohn's disease causing adhesions or inflammatory strictures Neoplasms, ...
indicated that macrophages and neutrophils in an inflamed colonic epithelium are the source of reactive oxygen species causing ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The term "neoplasm" is a synonym of "tumor". "Neoplasia" denotes the process of the formation of neoplasms/tumors, the process ... p. Neoplasm. ISBN 978-0781733908. "II Neoplasms". International Statistical Classification of Diseases and Related Health ...
The presence of fresh blood in the terminal ileum is presumed to indicate a non colonic source of bleeding. The overall ... H7 Shigella Salmonella Campylobacter jejuni Hemorrhoids Neoplasm - such as colorectal cancer Angiodysplasia Bleeding from a ... use is a risk factor for diverticular bleeding and NSAID-induced colonic ulcer; and recent colonoscopy with polypectomy ... site where a colonic polyp was removed Inflammatory bowel disease such as Crohn's disease or ulcerative colitis Rectal varices ...
These neoplasms have a characteristic transition of cells. The lining of the cyst consists of basoloid cells with indistinct ... This association has prognostic import, since cutaneous findings in children with Gardner Syndrome generally precede colonic ... These neoplasms are relatively uncommon and typically occur on the scalp, face, and upper extremities. Clinically, ... Malignant pilomatricoma List of cutaneous conditions List of cutaneous neoplasms associated with systemic syndromes Rapini, ...
indicated that macrophages and neutrophils in an inflamed colonic epithelium are the source of reactive oxygen species causing ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The term 'neoplasm' is a synonym of "tumor". 'Neoplasia' denotes the process of the formation of neoplasms/tumors, the process ... "II Neoplasms". World Health Organization. Retrieved 19 June 2014.. *^ a b Abrams, Gerald. "Neoplasia I". Retrieved 23 January ...
"Faecal microRNAs as a non-invasive tool in the diagnosis of colonic adenomas and colorectal cancer: A meta-analysis". ... it has been demonstrated as an independent prognostic factor in patients with pancreatic neuroendocrine neoplasms. miR-21 has ... "Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms". European Journal of Endocrinology ...
It is well documented that malignancy may be only focally present in mucinous neoplasms of the ovary, so thorough sampling is ... The appearance can look similar to colonic cancer. Clear stromal invasion is used to differentiate borderline tumors from ... Mucinous tumors are part of the surface epithelial-stromal tumor group of ovarian neoplasms, and account for approximately 36% ...
Gastric and colonic pacemakers have been tried. These are strips placed along the colon or stomach which create an electric ... Bowel obstruction: mechanical or functional obstruction of the bowel most commonly due to adhesions, hernias or neoplasms. ... Briejer MR, Prins NH, Schuurkes JA (October 2001). "Effects of the enterokinetic prucalopride (R093877) on colonic motility in ... Saunders MD (October 2004). "Acute colonic pseudoobstruction". Current Gastroenterology Reports. 6 (5): 410-6. doi:10.1007/ ...
2009). "Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms". ... the colonic cell line". Biochim. Biophys. Acta. 1498 (1): 32-43. doi:10.1016/s0167-4889(00)00075-6. PMID 11042348. Ciocca V, ...
Colonic transit studies may be used to rule out colonic inertia if there is a history of severe constipation. Continent ... Rarely, a neoplasm (tumour) may form on the leading edge of the intussusceptum. In addition, patients are frequently elderly ... anismus and colonic dysmotility exacerbate. Some believe that internal rectal intussusception represents the initial form of a ... "Solitary rectal ulcer syndrome mimicking rectal neoplasm on MRI". The British Journal of Radiology. 83 (995): e221-4. doi: ...
Hairy cell leukemia is also a neoplasm of B lymphocytes, but the neoplastic cells have a distinct morphology under the ... Colonic perforation secondary to chronic lymphocytic leukemia infiltration without Richter transformation. Leuk Lymphoma. 2011 ... ISBN 978-0-7817-5007-3. Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and ... Choi SM, O'Malley DP (December 2018). "Diagnostically relevant updates to the 2017 WHO classification of lymphoid neoplasms". ...
Precancer-Tubular adenoma (left of image), a type of colonic polyp and a precursor of colorectal cancer. Normal colorectal ... Srikumar Chakravarthi; Baba Krishnan; Malathy Madhavan (1999). "Apoptosis and expression of p53 in colorectal neoplasms". ... As summarized in the articles Carcinogenesis and Neoplasm, for sporadic cancers in general, a deficiency in DNA repair is ... "Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis". Nature. 363 (6429 ...
... and colonic adenomas, a premalignant lesion of colon adenocarcinoma. Furthermore epigenetic silencing of MORT is associated ... lymphoid neoplasm diffuse large B-cell lymphoma, pancreatic adenocarcinoma, rectum adenocarcinoma, skin cutaneous melanoma, and ...
In the colonic tissues of mice fed diet plus DOC similar changes in biomarkers occurred. Thus, 8-OH-dG was increased, DNA ... 1996). "Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice". Cancer Res. 56 (16): 3842-9. PMID 8706033 ... 1998). "Development of colonic adenocarcinomas in a mouse model of ulcerative colitis". Inflamm. Bowel Dis. 4 (3): 196-202. doi ... After 8-10 months, 45% to 56% of the mice developed colonic adenocarcinomas, and no mice had cancers of the small intestine. On ...
... s are a class of ovarian neoplasms that may be benign or malignant. Neoplasms in this group are ... The appearance can look similar to colonic or ovarian cancer, but typically originates from the appendix (see mucinous ... One rare but noteworthy condition associated with mucinous ovarian neoplasms is pseudomyxoma peritonei. As primary ovarian ... of all ovarian neoplasms In some cases mucinous tumors are characterized by more cysts of variable size and a rarity of surface ...
Neoplasms / cancer. *Diverticulitis / Diverticulosis. *Hernias. *Inflammatory bowel disease. *Colonic volvulus (sigmoid, caecal ...
Some solid malignant tumors, ( colonic, uterine and bronchogenic, and head and neck necrotic tumors, are more likely to become ... malignant neoplasms intestinal obstruction; decubitus ulcers; dental extraction; sickle cell disease; diabetes mellitus; ... often to yield colonic flora organisms. These are generally B. fragilis group, Clostridium spp., Enterobacteriaceae and ...
Of solid tumor neoplasms, ovarian cancer is most likely to provoke eosinophilia, though any other cancer can cause the ... Beeken WL, Northwood I, Beliveau C, Baigent G, Gump D (1987). "Eosinophils of human colonic mucosa: C3b and Fc gamma receptor ... The World Health Organization classifies these disorders into a) Myeloid and lymphoid neoplasms with eosinophilia and ... Reiter A, Gotlib J (2017). "Myeloid neoplasms with eosinophilia". Blood. 129 (6): 704-714. doi:10.1182/blood-2016-10-695973. ...
In 1986, a laboratory worker accidentally bruised herself with the needles she was using to inject colonic cancer cells into ... Frierman EM, Andrews JD (February 1976). "Occurrence of hematopoietic neoplasms in Virginia oysters (Crassostrea virginica)". ... Gugel EA, Sanders ME (December 1986). "Needle-stick transmission of human colonic adenocarcinoma". The New England Journal of ... have been found to be vulnerable to a transmissible neoplasm of the hemolymphatic system - effectively, leukemia. The cells ...
In contrast, in colon tumors compared to adjacent normal-appearing colonic mucosa, there are about 600 to 800 heavily ... Such mutations and epigenetic alterations can give rise to cancer (see malignant neoplasms). Thus, CpG island hyper/hypo- ...
In contrast, in one study of colon tumors compared to adjacent normal-appearing colonic mucosa, 1,734 CpG islands were heavily ... Such mutations and epigenetic alterations can give rise to cancer (see malignant neoplasms). Thus, CpG island hyper/hypo- ...
Benign neoplasms are typically but not always composed of cells which bear a strong resemblance to a normal cell type in their ... Bowel intussusception can occur with various benign colonic tumors. Cosmetic effects can be caused by tumors, especially those ... ISBN 92-832-2416-7. Gill SS, Heuman DM, Mihas AA (October 2001). "Small intestinal neoplasms". J. Clin. Gastroenterol. 33 (4): ... polyps of the colon are often referred to as benign but they are actually overgrowths of normal tissue rather than neoplasms. ...
... which may be benign neoplasms) or else a malignant neoplasm (cancer). These neoplasms are also indicated, in the diagram below ... In contrast, in colon tumors compared to adjacent normal-appearing colonic mucosa, there are about 600 to 800 somatically ... Neoplasms are mosaics of different mutant cells with both genetic and epigenetic changes that distinguish them from normal ... In this way, a population of mutant cells, called a clone, can expand in the neoplasm. Clonal expansion is the signature of ...
"Colonic Polyps". Retrieved 2010-04-13. "Management of Colonic Polyps and Adenomas". Retrieved 2010-04-13. "Colon Polyps (cont ... Some polyps are tumors (neoplasms) and others are non-neoplastic, for example hyperplastic or dysplastic. The neoplastic ones ... Ali Nawaz Khan with CME available "How I Do It" - Removing large or sessile colonic polyps. Dr. Brian Saunders MD FRCP; St. ... "Colonic Polyps". medlineplus.gov. Retrieved 2020-04-30. "Colon polyps - Symptoms and causes". Mayo Clinic. Retrieved 2020-04-30 ...
... see malignant neoplasms). Thus, CpG island hyper/hypo-methylation in the promoters of DNA repair genes are likely central to ... in one study of colon tumors compared to adjacent normal-appearing colonic mucosa, 1,734 CpG islands were heavily methylated in ...
Functional colonic disease *IBS. *Intestinal pseudoobstruction / Ogilvie syndrome. *Megacolon / Toxic megacolon. * ... Neoplasms and cancer. *Inflammatory bowel disease. *Gluten sensitivity. *Other. *Symptoms and signs *eponymous ...
Screening for colonic polyps as well as preventing them has become an important part of the management of the condition. ... Some polyps are tumors (neoplasms) and others are nonneoplastic (for example, hyperplastic or dysplastic). The neoplastic ones ... "How I Do It" - Removing large or sessile colonic polyps. Dr. Brian Saunders MD FRCP; St. Mark's Academic Institute; Harrow, ... Micrograph of a Peutz-Jeghers colonic polyp - a type of hamartomatous polyp. H&E stain. ...
Benign neoplasms are typically but not always composed of cells which bear a strong resemblance to a normal cell type in their ... Bowel intussusception can occur with various benign colonic tumors.[11] Cosmetic effects can be caused by tumors, especially ... Gill SS, Heuman DM, Mihas AA (October 2001). "Small intestinal neoplasms". J. Clin. Gastroenterol. 33 (4): 267-82. doi:10.1097/ ... polyps of the colon are often referred to as benign but they are actually overgrowths of normal tissue rather than neoplasms.[4 ...
Thus, a clone with a mutation in a tumor suppressor gene or oncogene will expand only in a neoplasm if that mutation gives the ... Macrophages and neutrophils in an inflamed colonic epithelium are the source of reactive oxygen species causing the DNA damages ... Some of the small polyps in the field defect shown in the photo of the opened colon segment may be relatively benign neoplasms ... November 2010). "Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic ...
Functional colonic disease *IBS. *Intestinal pseudoobstruction / Ogilvie syndrome. *Megacolon / Toxic megacolon. * ... Neoplasms and cancer. *Inflammatory bowel disease. *Gluten sensitivity. *Other. *Symptoms and signs *eponymous ...
... familial nonpolyposis Colonic atresia Colonic malakoplakia Color blindness Colorado tick fever Colver-Steer-Godman syndrome ... Carrington syndrome Cartilage-hair hypoplasia Cartilage hair hypoplasia like syndrome Cartilaginous neoplasms Cartwright-Nelson ... hypoxia Cerebral malformations hypertrichosis claw hands Cerebral palsy Cerebral thrombosis Cerebral ventricle neoplasms ... Choriocarcinoma Chorioretinitis Chorioretinopathy dominant form microcephaly Choroid plexus cyst Choroid plexus neoplasms ...
Misago N, Narisawa Y (September 2006). "Cytokeratin 15 expression in neoplasms with sebaceous differentiation". Journal of ... isografts from normal and transgenic mice to study the programming of positional information along the duodenal-to-colonic axis ...
... neoplasm seeding MeSH C23.550.727.650.895 - neoplasms, unknown primary MeSH C23.550.727.655 - neoplasm recurrence, local MeSH ... colonic polyps MeSH C23.300.825.557 - nasal polyps MeSH C23.300.970.500 - intestinal volvulus MeSH C23.550.073.093 - arrhythmia ... neoplasm metastasis MeSH C23.550.727.650.560 - lymphatic metastasis MeSH C23.550.727.650.645 - neoplasm circulating cells MeSH ... C23.550.727.670 - neoplasm regression, spontaneous MeSH C23.550.727.700 - neoplasm, residual MeSH C23.550.737.500 - retrograde ...
People with BHD were once thought to be at higher risk for colorectal polyps and neoplasms, but this has been disproven. The ... These include multinodular goiter, medullary thyroid carcinoma, parotid oncocytoma, colonic polyposis, connective tissue nevus ...
Colonic Neoplasms, Rectal Neoplasms Cancer trial. Review trial description, criteria and location information here. ... Pfizer is currently recruiting for the NCT00063427 Colorectal Neoplasms, ...
Disease relevance of Colonic Neoplasms. *The relative risk in men with both cholesterol greater than or equal to 250 mg per ... Biological context of Colonic Neoplasms. *The APC gene on chromosome 5 causing adenomatous polyposis coli represents a minority ... Analytical, diagnostic and therapeutic context of Colonic Neoplasms. *Serum cholesterol levels in adenomatous polyps and cancer ... Gene context of Colonic Neoplasms. *The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon ...
Carcinoembryonic Antigen Present in Human Colonic Neoplasms Serially Propagated in Hamsters. By David M. Goldenberg, Hans J. ... Carcinoembryonic Antigen Present in Human Colonic Neoplasms Serially Propagated in Hamsters. By David M. Goldenberg, Hans J. ... Carcinoembryonic Antigen Present in Human Colonic Neoplasms Serially Propagated in Hamsters Message Subject. (Your Name) has ... Carcinoembryonic antigen, as measured by radioimmunoassay, is present in two different human colonic tumors that have been ...
Advanced EndoLaparoscopic Resection of Colonic Neoplasms: the Latest Techniques and Technology. Reuben D Shin, MD, Peter W ... Methods: We present a video of advanced endolaparoscopic resection of colonic neoplasms to demonstrate new techniques and tips. ...
Clinical trial for Colonic Neoplasms , Establishing Effective Screening Methods for Diagnosing Hereditary Nonpolypoisis ...
Malignant neoplasm of colon , GASTROINTESTINAL DISORDER , Gastrointestinal Neoplasm , Esophageal Cancer , Duodenal Polyp , ... within the gastrointestinal tract for endoscopic treatment of early gastrointestinal neoplasms involving the resection of the ... Endoscopic resection can be an appropriate approach in early neoplasms, challenging adenomas or sub-epithelial lesions. ...
Rapid induction of colonic neoplasms in ICR mice treated with azoxymethane followed by dextran sodium sulfate. Takuji Tanaka, ... Besides these neoplasms, dysplastic lesions and aberrabt crypt foci (ACF) developed in the colonic mucosa and the frequency of ... Rapid induction of colonic neoplasms in ICR mice treated with azoxymethane followed by dextran sodium sulfate ... Rapid induction of colonic neoplasms in ICR mice treated with azoxymethane followed by dextran sodium sulfate ...
Bordonaro M, Lazarova D. Hypothesis: Induction of biomarkers for detection of colonic neoplasms. J Cancer 2018; 9(1):166-173. ... The concept of detecting inducible markers of colonic neoplasms is novel, and is substantiated by the significant physiological ... Hypothesis: Induction of biomarkers for detection of colonic neoplasms Michael Bordonaro, Darina Lazarova✉ ... We posit that gCD and propolis induce the release of neoplasm-associated biomarkers in systemic circulation (e.g., metabolites ...
Robotic excision of a colonic neoplasm with ICG as a tumor localizer and colonoscopic assistance. Zeitschrift:. Techniques in ... Robotic excision of a colonic neoplasm with ICG as a tumor localizer and colonoscopic assistance ... Nagata J, Fukunaga Y, Akiyoshi T, Konishi T, Fujimoto Y, Nagayama S, Yamamoto N, Ueno M (2016) Colonic marking with near- ... Watanabe M, Murakami M, Ozawa Y, Yoshizawa S, Matsui N, Aoki T (2017) Intraoperative identification of colonic tumor sites ...
... On-line free medical diagnosis assistant. Ranked list of possible diseases ... "colonic neoplasms"Drugs, active principles and "colonic neoplasms"Medicinal plantsQuestions and answers from other usersNews ... Colonic neoplasms (Cancer of Colon; Colon Cancer). Tumors or cancer of the colon. ...
Lipkin M, Deschner E, Troncale F (1970). "Cell differentiation and the development of colonic neoplasms". CA: A Cancer Journal ... "Biochemical measure of the volume doubling time of human pulmonary neoplasms". Cancer. 55 (7): 1530-5. doi:10.1002/1097-0142( ...
Elias, H & Hyde, DM 1982, Separation and spread of nuclear fragments ("nucleotesimals") in colonic neoplasms, Human Pathology ... Elias, Hans ; Hyde, Dallas M. / Separation and spread of nuclear fragments ("nucleotesimals") in colonic neoplasms. In: Human ... Elias, H., & Hyde, D. M. (1982). Separation and spread of nuclear fragments ("nucleotesimals") in colonic neoplasms. Human ... Separation and spread of nuclear fragments ("nucleotesimals") in colonic neoplasms. Human Pathology. 1982;13(7):635-639. https ...
Fingerprint Dive into the research topics of DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and ... title = "DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohns Colitis: Implications for ... DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohns Colitis: Implications for ... DNA Methylation and Mutation of Small Colonic Neoplasms in Ulcerative Colitis and Crohns Colitis: Implications for ...
Colonic Neoplasms. Colorectal Neoplasms. Intestinal Neoplasms. Gastrointestinal Neoplasms. Digestive System Neoplasms. ... Neoplasms by Site. Neoplasms. Digestive System Diseases. Gastrointestinal Diseases. Colonic Diseases. Intestinal Diseases. ... SEMS Placement Followed by Chemotherapy and Surgery for Obstructing Left-sided Colonic Cancer. The safety and scientific ... Left-sided colonic tumor. Intestinal obstruction. Self-expanding metallic stent. Neoadjuvant chemotherapy. Stoma. ...
Colonic Neoplasms. Signs and Symptoms. Colorectal Neoplasms. Intestinal Neoplasms. Gastrointestinal Neoplasms. Digestive System ... Neoplasms by Site. Neoplasms. Digestive System Diseases. Gastrointestinal Diseases. Colonic Diseases. Intestinal Diseases. ... Following open colonic surgery patients are fatigued and loss body mass and have a reduction in physical function, but the ... Patients undergoing laparoscopic colonic surgery are compared with a historical cohort of patients undergoing similar open ...
Colonic Neoplasms / chemically induced* * Colonic Neoplasms / pathology * Colonic Neoplasms / prevention & control* * Infusion ... Leptin reduces the development of the initial precancerous lesions induced by azoxymethane in the rat colonic mucosa ... This study investigates in rat colonic mucosa (1) the effects of hyperleptinemia on epithelial cell proliferation and ... azoxymethane-induced colonic lesions study). The effects of injections or continuous infusion of leptin into the colon were ...
Colonic Neoplasms / pathology * Dinoprostone / metabolism* * Humans * In Vitro Techniques * Leukocytes, Mononuclear / ... Enhanced secretion of prostaglandin E2 by tissue-fixed macrophages in colonic carcinoma Digestion. 1990;47(3):160-6. doi: ... PGE2 production by tissue-fixed macrophages from within colonic polyps was found to be normal. These results could not be ... Modulation of levels of prostaglandin production within colonic tumours may play a role in the rate of growth and vascularity ...
Colonic Neoplasms Resource Information The concept Colonic Neoplasms represents the subject, aboutness, idea or notion of ... Colonic Neoplasms,/a,,/span, - ,span property=potentialAction typeOf=OrganizeAction,,span property=agent typeof= ... Colonic Neoplasms,/a,,/span, - ,span property=potentialAction typeOf=OrganizeAction,,span property=agent typeof= ... Colonic Neoplasms. Local Identifier. http://link.collegeofphysicians.org/resource/555ZNmLP-iE/ Network Identifier. http:// ...
The standard procedure for treating colonic cancer is changing from open surgery to laparoscopic surgery. Following open ... Changes in Fatigue and Physical Function Following Laparoscopic Colonic Surgery. Trial Phase:. N/A. Minimum Age:. N/A. Maximum ... elective colonic cancer surgery. - hemicolectomy or sigmoid resection. - informed consent. Exclusion Criteria:. - disseminated ... Colonic Neoplasms. *Fatigue. .map{width:100%;height:300px;margin-bottom:15px;} Name. Location. ...
Ultrasonographic diagnosis of clinically non-palpable primary colonic neoplasms PRICE J Br J Radiol 61, 190-195, 1988 ... Transabdominal sonographic appearance of adult colonic polyps * * YABUNAKA Koichi * Graduate School of Health Sciences, ... Ultrasonographic detection of colonic polyps : screening for polyps less than 2 cm in diameter YUASA H ... Diagnosis and staging of colonic tumors by conventional abdominal sonography as compared with hydrocolonic sonography LIMBERG B ...
... violet is absorbed into intestinal and neoplastic cells and is used to identify Barretts esophagus and colonic neoplasms. ... characterization of colonic polyps and colorectal cancer, and in screening for dysplasia in individuals with ulcerative colitis ...
... colonic neoplasms; meta-analysis; occupational diseases ...
List of variants reported as likely benign for colonic neoplasm by Pathway Genomics Included ClinVar conditions (19):* ... Gastric polyposis; Duodenal polyposis; Adenomatous colonic polyposis; Intestinal polyp; Hyperplastic colonic polyposis ... Colorectal polyposis; Neoplasm of the colon. *Desmoid disease, hereditary; Carcinoma of colon; Familial adenomatous polyposis 1 ... Adenomatous colonic polyposis. *Adrenocortical carcinoma, hereditary; Familial cancer of breast; Glioma susceptibility 1; ...
Adenoma, Animals, Body Weight, Colonic Neoplasms, Colonic Polyps, Female, Glucagon-Like Peptide 2, Glucagon-Like Peptides, ... Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice. Research output: Contribution to journal ... AIMS: In the present study, the effects of GLP-2 treatment on the growth of chemically induced colonic neoplasms were ... RESULTS: Colonic polyps developed in 100% of the mice, regardless of treatment. Survival data revealed no statistical ...
Brain Neoplasms. D001932. EFO:0003833. brain neoplasm. 1. ClinicalTrials. Colonic Neoplasms. D003110. EFO:1001950. colon ... Skin Neoplasms. D012878. EFO:0004198. skin neoplasm. 2. ClinicalTrials. ClinicalTrials. Head and Neck Neoplasms. D006258. EFO: ...
Colonic Neoplasms. D003110. EFO:0004288. colonic neoplasm. 2. ClinicalTrials. Dermatomyositis. D003882. EFO:0000557. juvenile ... Neoplasms. D009369. EFO:0000616. neoplasm. 4. ATC. Scleroderma, Systemic. D012595. EFO:0000717. systemic scleroderma. 2. ... Breast Neoplasms. D001943. EFO:0003869. breast neoplasm. 2. ClinicalTrials. Diabetic Neuropathies. D003929. EFO:1000783. ... Pancreatic Neoplasms. D010190. EFO:0003860. pancreatic neoplasm. 2. ClinicalTrials. Pemphigoid, Benign Mucous Membrane. D010390 ...
Colonic neoplasms; cytokines; glycolytic metabolism; intestinal epithelial cells; macrophage; tumorigenesis. PMID:. 32056981. ...
COLONIC NEOPLASMS; COLORECTAL CANCER; COLORECTAL CANCER SCREENING; MOLECULAR BIOLOGY; MOLECULAR ONCOLOGY. PMID:. 25994221. ... The observation of tumour cell exfoliation into the mucocellular layer of the colonic epithelium and proven stability of DNA in ...
Colonic Neoplasms. Colorectal Neoplasms. Intestinal Neoplasms. Gastrointestinal Neoplasms. Digestive System Neoplasms. ... Neoplasms by Site. Neoplasms. Digestive System Diseases. Gastrointestinal Diseases. Colonic Diseases. Intestinal Diseases. ...
Colonic Neoplasm Intervention Behavioral: There is no intervention, only observation Study Groups/Cohorts Patients with colon ...
  • Endoscopic resection can be an appropriate approach in early neoplasms, challenging adenomas or sub-epithelial lesions. (centerwatch.com)
  • At Wk 3, colonic adenomas developed in 2 of 5 mice (40% incidence with 0.4 ± 0.5 multiplicity). (aacrjournals.org)
  • Colonic diverticulosis may represent a risk factor for colonic adenomas by virtue of the fact that evolving data suggest that these 2 conditions may share common risk factors such as Western dietary pattern and physical inactivity. (dovepress.com)
  • This study aims to investigate the association between colonic diverticulosis and colonic adenomas in mainland China. (dovepress.com)
  • Multivariate logistic regression and stratified analysis were used to evaluate the associations between the prevalence of diverticulosis and age, sex, and presence of colonic adenomas and advanced adenomas. (dovepress.com)
  • Evolving data suggested that colonic diverticular disease and colonic adenomas may share common risk factors such as Western dietary pattern, 1 lifestyle factors (overweight, obesity, and physical inactivity), 2 and cigarette smoking. (dovepress.com)
  • 3 Both the prevalence of diverticulosis and colonic adenomas increased with age, 4 , 5 and varied with geography and ethnics. (dovepress.com)
  • Most colonic adenomas are considered as precursors of colorectal carcinomas. (isciii.es)
  • Notwithstanding, the number of flat or depressed colorectal lesions has increased in the last decades, representing up to 38% of colonic adenomas (9). (isciii.es)
  • Carcinoembryonic antigen, as measured by radioimmunoassay, is present in two different human colonic tumors that have been serially transplanted and maintained in the cheek pouches of unconditioned, adult golden hamsters. (sciencemag.org)
  • SBS reduced the death rate through decreasing the incidence and multiplicity of colonic tumors. (biomedcentral.com)
  • Epithelial tumors of the papilla of Vater are rare neoplasms of the gastrointestinal tract. (unboundmedicine.com)
  • Data on whether the prevalence of colorectal tumors is increased in patients with sporadic ampullary neoplasms are scarce. (unboundmedicine.com)
  • However, the finding of 2 rectal carcinomas among patients with ampullary neoplasms supports the place of screening colonoscopy for the diagnostic work-up of ampullary tumors. (unboundmedicine.com)
  • We conclude that in early colorectal cancer arising in pedunculated polyps (0-Ip), mucosal endoscopic resection would be indicated as only treatment in Haggitt levels 1, 2 and 3, tumors smaller than 2 cm, well- or moderately differentiated, without vascular or lymphatic affection, with submucosal infiltration lower than 1 µm from the muscularis mucosae and maximal submucosal width lower than 4 µm, and undergoing en bloc resection. (isciii.es)
  • 5 ] revealed that 48% of appendectomy specimens with diverticulosis harbored appendiceal neoplasms including well-differentiated neuroendocrine tumors (carcinoid), mucinous adenoma, tubular adenoma, and adenocarcinoma. (hindawi.com)
  • Neoplasms may be benign or malignant. (thefreedictionary.com)
  • Neoplasms show partial or complete lack of structural organization and functional coordination with the normal tissue, and usually form a distinct mass of tissue that may be either benign ( benign tumor ) or malignant ( cancer ). (thefreedictionary.com)
  • This is a retrospective and prospective multicenter registry to collect long-term data (1 year) on patients who have or will undergo Endoscopic resection such as EMR, ESD, EFTR, STER, etc. within the gastrointestinal tract for endoscopic treatment of early gastrointestinal neoplasms involving the resection of the superficial layers, mucosa and submucosa, of the tract wall. (centerwatch.com)
  • Besides these neoplasms, dysplastic lesions and aberrabt crypt foci (ACF) developed in the colonic mucosa and the frequency of the latter was well correlated with the multiplicity of the colonic malignancy. (aacrjournals.org)
  • This study investigates in rat colonic mucosa (1) the effects of hyperleptinemia on epithelial cell proliferation and development of aberrant crypts, earliest preneoplastic lesions, and (2) whether luminal leptin affects cell proliferation. (nih.gov)
  • Cell population kinetics of 1,2-dimethylhydrazine-induced colonic neoplasms and their adjacent colonic mucosa in the mouse. (mcmaster.ca)
  • Immunohistochemical investigation of such dysplasias and neoplasms revealed that all lesions expressed positive reactivities against β-catenin, cyclooxygenase-2, and inducible nitric oxide synthase, but did not show p53 immunoreactivity. (aacrjournals.org)
  • Leptin (1 mg/kg/d) or vehicle was administered systemically by miniosmotic pump in Fischer 344 rats either for 7 days (BrdU-labeling indices study) or 23 days (azoxymethane-induced colonic lesions study). (nih.gov)
  • One hundred five and 59 colonic lesions were detected on FDG PET/CT and colonoscopy, respectively. (bvsalud.org)
  • The present essay is aimed at demonstrating the findings of the most common colonic lesions and pseudolesions observed at virtual colonoscopy and familiarizing the readers with the main technical features of the method. (scielo.br)
  • The expression of p16, β-catenin, and Gli1 and the in vivo methylation status of the p16 gene were also analyzed in serial sections of colonic precancerous lesions. (aacrjournals.org)
  • Neoadjuvant chemotherapy was administered 1 week after successful SEMS placement and decompression for patient with obstructing left-sided colonic cancer. (clinicaltrials.gov)
  • The standard procedure for treating colonic cancer is changing from open surgery to laparoscopic surgery. (clinicaltrials.gov)
  • As such, the array of contemporary screening methods now used for CRC prevention center on being able to successfully recognize and remove these precancerous neoplasms (adenomatous polyps) before they develop into cancer. (thepermanentejournal.org)
  • The most common applications for chromoendoscopy are the following: identification of squamous cell carcinomas or dysplasia of the esophagus, identification of Barrett's esophagus and dysplasia, identification of early gastric cancer, characterization of colonic polyps and colorectal cancer, and in screening for dysplasia in individuals with ulcerative colitis. (wikipedia.org)
  • For over a decade, CTC has been utilized in the investigation of colonic polyps and colorectal cancer (CRC). (scielo.br)
  • Pancreatic mucinous cystic neoplasm defined by ovarian stroma: demographics, clinical features, and prevalence of cancer. (thefreedictionary.com)
  • See Cancer , Doubling time , Intraductal papillary-mucinous neoplasm of pancreas, Metastases, Papillary & solid neoplasm of pancreas. (thefreedictionary.com)
  • Furthermore, a recent study showed that 43.6% of the cases coincided with appendiceal neoplasm and regional colonic carcinoma [ 6 ]. (hindawi.com)
  • pylori infection is a risk factor for colonic neoplasms , but all of them involved relatively small case populations, Dr. (thefreedictionary.com)
  • The prevalence of colonic diverticulosis and adenoma was 2.4% and 13.2%, respectively. (dovepress.com)
  • 4 , 5 The proposed common mechanisms for diverticulosis and colonic adenoma formation include lack of dietary fiber, increased saturated fats, and slow colonic transit time. (dovepress.com)
  • We present a video of advanced endolaparoscopic resection of colonic neoplasms to demonstrate new techniques and tips. (sages.org)
  • Colonoscopy Assisted Local Resection for Colonic Neoplasm. (nii.ac.jp)
  • The diagnosis of solid and papillary epithelial neoplasm carries an excellent prognosis with surgical resection. (thefreedictionary.com)
  • Those polyps with a size bigger than 3 cm, affecting more than one third of circumference or two colonic haustras, or with flat or depressed morphology are more difficult to be resected with the conventional endoscopic polypectomy, thus with the new endoscopic approaches, such as endoscopic mucosal resection, the number of resected polyps has increased, avoiding the surgical act in many cases (10). (isciii.es)
  • As of now, it is debatable whether patients found to have distal HPs only by screening FS should undergo a colonoscopy for further evaluation of synchronous proximal neoplasms (SPNs). (thepermanentejournal.org)
  • CONCLUSIONS: The present results clearly indicate that GLP-2 promotes the growth of mucosal neoplasms. (ku.dk)
  • AIMS: In the present study, the effects of GLP-2 treatment on the growth of chemically induced colonic neoplasms were investigated. (ku.dk)
  • We posit that gCD and propolis induce the release of neoplasm-associated biomarkers in systemic circulation (e.g., metabolites, neoplastic, apoptotic, and immune response proteins), and these markers could be used to detect early stage intestinal neoplasms. (jcancer.org)
  • Mucinous cystic neoplasms of the liver: a clinicopathological study and comparison with intraductal papillary neoplasms of the bile duct. (thefreedictionary.com)
  • 4 ] reported a 25% association between appendiceal mucinous neoplasms and DDA. (hindawi.com)
  • A 30 year old unmarried female reported with a diagnosis of spindle cell neoplasm from her neck node in February 2012. (thefreedictionary.com)
  • METHODS: In 210 female C57bl mice, colonic tumours were initially induced with the methylating carcinogen 1,2-dimethylhydrazine (DMH) and mice were then treated with GLP-2. (ku.dk)
  • Both methods were comparable in identifying advanced neoplasms. (unicare.com)
  • Colonic adenocarcinomas were seen in 2 of 5 mice (40% incidence with 2.0 ± 3.5 multiplicity) at Wk 4. (aacrjournals.org)
  • After this time point, the incidence and multiplicity of colonic neoplasms gradually increased with time and reached to 100% incidence at Wk 6. (aacrjournals.org)
  • The average incidence of paediatric CNS neoplasm is 15. (thefreedictionary.com)
  • SBS treatment reduced the death rate of mice and decreased the incidence and multiplicity of colonic neoplasms. (biomedcentral.com)
  • Bordonaro M, Lazarova D. Hypothesis: Induction of biomarkers for detection of colonic neoplasms. (jcancer.org)
  • Modulation of levels of prostaglandin production within colonic tumours may play a role in the rate of growth and vascularity of these tumours and in the regulation of the local immune response to malignancy. (nih.gov)
  • Importantly, clostridial bacteremia is frequently associated with underlying medical conditions, such as colonic malignancy. (semanticscholar.org)
  • The concept of detecting inducible markers of colonic neoplasms is novel, and is substantiated by the significant physiological effects of gCD and propolis on neoplastic colonic cells in culture and on early neoplastic development in Apc Min mice. (jcancer.org)
  • Crystal violet is absorbed into intestinal and neoplastic cells and is used to identify Barrett's esophagus and colonic neoplasms. (wikipedia.org)
  • The prevalence of colonic neoplasm among the patients with cryptogenic PLA was not as high as that in previous studies. (bvsalud.org)
  • Following open colonic surgery patients are fatigued and loss body mass and have a reduction in physical function, but the investigators do not know if this is also the case following laparoscopic surgery. (clinicaltrials.gov)
  • Patients undergoing laparoscopic colonic surgery are compared with a historical cohort of patients undergoing similar open colonic surgery (right hemicolectomy and sigmoid resections). (clinicaltrials.gov)
  • Among them, all the patients with cryptogenic PLA were recommended for colonoscopic exam to check for colonic neoplasm. (bvsalud.org)
  • 50% of the colonic polyps in patients with ampullary neoplasms were located in the ascending colon. (unboundmedicine.com)
  • Male Crj: CD-1 (ICR) mice were given a single and low dose of a genotoxic colonic carcinogen azoxymethane (AOM, 10 mg/kg bw, i.p. injection) followed by one-week oral exposure (2% in drinking water) of a non-genotoxic carcinogen dextran sodium sulfate (DSS) to develop an efficient and rapid animal model for colon carcinogenesis. (aacrjournals.org)
  • RESULTS: Colonic polyps developed in 100% of the mice, regardless of treatment. (ku.dk)
  • mice : inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms. (nii.ac.jp)
  • The secondary outcome was to identify individuals with flat or depressed neoplasms, as defined by the Paris classification system. (unicare.com)
  • The observation of tumour cell exfoliation into the mucocellular layer of the colonic epithelium and proven stability of DNA in a harsh stool environment make stool DNA a particularly promising marker. (nih.gov)
  • Diseases associated with UCHL3 include Colonic Benign Neoplasm . (genecards.org)
  • This study examines how fatigue, quality of life, physical function, and body composition changes following laparoscopic colonic surgery. (clinicaltrials.gov)
  • Journal Article] An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide : its potential use for preclinical chemoprevention studies. (nii.ac.jp)