AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and Occupations
Colonic NeoplasmsDimethylhydrazinesIntestinal PolypsAdenomaColonColonic DiseasesIntestinal MucosaPancreatic NeoplasmsColonic PolypsNeoplasmsNeoplasms, Cystic, Mucinous, and SerousColitisNeoplasms, Multiple PrimarySkin NeoplasmsGastrointestinal TransitColonic Pseudo-ObstructionDiverticulosis, ColonicKidney NeoplasmsGastrointestinal MotilityNeoplasms, Second PrimaryAdenocarcinoma, MucinousImmunohistochemistry
Colonic Neoplasms
Tumors or cancer of the COLON.
Dimethylhydrazines
Hydrazines substituted with two methyl groups in any position.
Intestinal Polyps
Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.
Adenoma
A benign epithelial tumor with a glandular organization.
Colon
The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.
Colonic Diseases
Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).
Intestinal Mucosa
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Pancreatic Neoplasms
Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Colonic Polyps
Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Neoplasms, Cystic, Mucinous, and Serous
Neoplasms containing cyst-like formations or producing mucin or serum.
Colitis
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
Neoplasms, Multiple Primary
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Skin Neoplasms
Tumors or cancer of the SKIN.
Gastrointestinal Transit
Passage of food (sometimes in the form of a test meal) through the gastrointestinal tract as measured in minutes or hours. The rate of passage through the intestine is an indicator of small bowel function.
Colonic Pseudo-Obstruction
Functional obstruction of the COLON leading to MEGACOLON in the absence of obvious COLONIC DISEASES or mechanical obstruction. When this condition is acquired, acute, and coexisting with another medical condition (trauma, surgery, serious injuries or illness, or medication), it is called Ogilvie's syndrome.
Diverticulosis, Colonic
A pathological condition characterized by the presence of a number of COLONIC DIVERTICULA in the COLON. Its pathogenesis is multifactorial, including colon aging, motor dysfunction, increases in intraluminal pressure, and lack of dietary fibers.
Kidney Neoplasms
Tumors or cancers of the KIDNEY.
Gastrointestinal Motility
The motor activity of the GASTROINTESTINAL TRACT.
Neoplasms, Second Primary
Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.
Adenocarcinoma, Mucinous
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Immunohistochemistry
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

Classification of human colorectal adenocarcinoma cell lines. (1/11349)

Eleven human colorectal adenocarcinoma cell lines established in this laboratory were classified into three groups based on morphological features (light and electron microscopy), modal chromosome number, and ability to synthesize carcinoembryonic antigen (CEA). Group 1 cell lines contained both dedifferentiated and differentiating cells growing in tight clusters or islands of epithelium-like cells; their modal chromosome number was about 47, and they synthesized small to moderate amounts of CEA. Group 2 cell lines were more dedifferentiated, were hyperdiploid, and synthesized small amounts of CEA. Group 3 cell lines were morphologically similar to those of Group 1 by light microscopy. They differed ultrastructurally by containing microvesicular bodies; the modal chromosome number varied from hyperdiploid to hypertriploid or they had bimodal populations of hypodiploid and hypertriploid cells, and they synthesized relatively large amounts of CEA. No correlation could be found between Broder's grade or Duke's classification of the original tumor and modal chromosome number or ability to synthesize CEA. These findings support Nowell's hypothesis that the stem line is different for each solid tumor, which makes it difficult to relate chromosomal changes to the initiation of the neoplastic state.  (+info)

PKCdelta acts as a growth and tumor suppressor in rat colonic epithelial cells. (2/11349)

We have analysed the expression of three calcium-independent isoforms of protein kinase C (PKC), PKCdelta, PKCepsilon and PKCzeta, in an in vitro model of colon carcinogenesis consisting of the nontumorigenic rat colonic epithelial cell line D/WT, and a derivative src-transformed line D/src. While PKCzeta and PKCepsilon showed similar protein levels, PKCdelta was markedly decreased in D/src cells when compared to the D/WT line. To assess whether down-regulation of PKCdelta was causally involved in the neoplastic phenotype in D/src cells, we prepared a kinase-defective mutant of PKCdelta. Stable transfection of this sequence caused morphological and growth changes characteristic of partial transformation in D/WT cells. Moreover, to test whether PKCdelta was involved in growth control and transformation in this model, we overexpressed PKCdelta in D/src cells. Transfected cells underwent marked growth and morphological modifications toward the D/WT phenotype. In a late stage in culture, transfected cells ceased to proliferate, rounded up and degenerated into multinucleated, giant-like cells. We conclude that PKCdelta can reverse the transformed phenotype and act as a suppressor of cell growth in D/src cells. Moreover, our data show that downregulation of this isoenzyme of PKC may cooperate in the neoplastic transformation induced by the src oncogene in D/WT cells.  (+info)

The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells. (3/11349)

The acquisition of invasiveness is a crucial step in the malignant progression of cancer. In cancers of the colon and of other organs the E-cadherin/catenin complex, which is implicated in homotypic cell-cell adhesion as well as in signal transduction, serves as a powerful inhibitor of invasion. We show here that one allele of the alphaE-catenin (CTNNA1) gene is mutated in the human colon cancer cell family HCT-8, which is identical to HCT-15, DLD-1 and HRT-18. Genetic instability, due to mutations in the HMSH6 (also called GTBP) mismatch repair gene, results in the spontaneous occurrence of invasive variants, all carrying either a mutation or exon skipping in the second alphaE-catenin allele. The alphaE-catenin gene is therefore, an invasion-suppressor gene in accordance with the two-hit model of Knudsen for tumour-suppressor genes.  (+info)

Mechanisms related to [18F]fluorodeoxyglucose uptake of human colon cancers transplanted in nude mice. (4/11349)

[18F]Fluorodeoxyglucose ([18F]FDG), a glucose analogue, has been widely used for tumor imaging. To investigate the mechanisms related to [18F]FDG uptake by tumors, an experiment involving nude mice was performed. METHODS: Human colon cancer cell lines SNU-C2A, SNU-C4 and SNU-C5 were transplanted to nude mice. Using immunohistochemical staining and Western blot, the expression of glucose transporter (Glut) isoforms (Glut-1 through -5) in xenografted tumors was analyzed. For the analysis of messenger ribonucleic acid (mRNA) expression, reverse-transcription polymerase chain reaction and Northern blot were used and the enzyme activity of hexokinase in cancer tissues was measured by continuous spectrophotometric rate determination. RESULTS: [18F]FDG uptake in SNU-C4 and SNU-C5 cells was higher than in normal colon cells. Among these cells and xenografted tumors, SNU-C5 showed the highest level of [18F]FDG uptake, followed by SNU-C4 and SNU-C2A. An immunostaining experiment showed intense staining of Glut-1 in SNU-C5 tumors but somewhat faint staining in SNU-C4. SNU-C5 tumors also showed positive staining with Glut-3, although this was not the case with SNU-C2A and SNU-C4. Western blot analysis showed the expression of Glut-1 and Glut-3 in all tumors. Experiments involving Northern blot analysis and reverse-transcription polymerase chain reaction confirmed the overexpression of Glut-1 mRNA in all tumors, with the highest level in SNU-C5. The level of Glut-3 mRNA was also elevated in SNU-C5 tumors but not in SNU-C2A and SNU-C4. The enzyme activity of hexokinase did not vary among different tumors. CONCLUSION: Gluts, especially Glut-1, are responsible for [18F]FDG uptake in a nude mouse model of colon cancer rather than hexokinase activity. Increased numbers of glucose transporters at the plasma membrane of cancer cells is attributed to an increased level of transcripts of glucose transporter genes and may be a cause of increased [18F]FDG uptake, at least in colon cancer tumors.  (+info)

In vivo isolated kidney perfusion with tumour necrosis factor alpha (TNF-alpha) in tumour-bearing rats. (5/11349)

Isolated perfusion of the extremities with high-dose tumour necrosis factor alpha (TNF-alpha) plus melphalan leads to dramatic tumour response in patients with irresectable soft tissue sarcoma or multiple melanoma in transit metastases. We developed in vivo isolated organ perfusion models to determine whether similar tumour responses in solid organ tumours can be obtained with this regimen. Here, we describe the technique of isolated kidney perfusion. We studied the feasibility of a perfusion with TNF-alpha and assessed its anti-tumour effects in tumour models differing in tumour vasculature. The maximal tolerated dose (MTD) proved to be only 1 microg TNF-alpha. Higher doses appeared to induce renal failure and a secondary cytokine release with fatal respiratory and septic shock-like symptoms. In vitro, the combination of TNF-alpha and melphalan did not result in a synergistic growth-inhibiting effect on CC 531 colon adenocarcinoma cells, whereas an additive effect was observed on osteosarcoma ROS-1 cells. In vivo isolated kidney perfusion, with TNF-alpha alone or in combination with melphalan, did not result in a significant anti-tumour response in either tumour model in a subrenal capsule assay. We conclude that, because of the susceptibility of the kidney to perfusion with TNF-alpha, the minimal threshold concentration of TNF-alpha to exert its anti-tumour effects was not reached. The applicability of TNF-alpha in isolated kidney perfusion for human tumours seems, therefore, questionable.  (+info)

Cancer risk in close relatives of women with early-onset breast cancer--a population-based incidence study. (6/11349)

Inherited susceptibility to breast cancer is associated with an early onset and bilateral disease. The extent of familial risks has not, however, been fully assessed in population-based incidence studies. The purpose of the study was to quantify the risks for cancers of the breast, ovary and other sites of close relatives of women in whom breast cancer was diagnosed at an early age. Records collected between 1943 and 1990 at the Danish Cancer Registry were searched, and 2860 women were found in whom breast cancer was diagnosed before age 40. Population registers and parish records were used to identify 14 973 parents, siblings and offspring of these women. Cancer occurrence through to 31 December 1993 was determined within the Cancer Registry's files and compared with national incidence rates. Women with early-onset breast cancer were at a nearly fourfold increased risk of developing a new cancer later in life (268 observed vs. 68.9 expected). The excess risk was most evident for second cancer of the breast (181 vs. 24.5) and for ovarian cancer (20 vs. 3.3). For mothers and sisters, risks for cancers of the breast and ovary were significantly increased by two- to threefold. Bilateral breast cancer and breast-ovarian cancer were very strong predictors of familial risks, with one in four female relatives predicted to develop breast and/or ovarian cancer by age 75. Mothers had a slightly increased risk of colon cancer, but not endometrial cancer. The risk for breast cancer was also increased among fathers (standardized incidence ratio 2.5; 95% CI 0.5-7.4) and especially brothers (29; 7.7-74), although based on small numbers. The risk for prostatic cancer was unremarkable. In this large population-based survey, the first-degree relatives of women who developed breast cancer before age 40 were prone to ovarian cancer as well as male and female breast cancer, but not other tumours that may share susceptibility genes with breast cancer.  (+info)

Bombesin stimulates adhesion, spreading, lamellipodia formation, and proliferation in the human colon carcinoma Isreco1 cell line. (7/11349)

The neuropeptide bombesin and its mammalian homologue, gastrin-releasing peptide (GRP), enhance proliferation in some but not all human tumor cell lines. The pathophysiological relevance of the bombesin/GRP receptor (GRP-R), which is expressed in 30% of human colon tumor cell lines and in 24-40% of native tumors, has not been clearly assessed at this time. We studied the effects of bombesin in the recently characterized human colon carcinoma Isreco1 cell line. Competitive reverse transcription-PCR showed a high GRP-R mRNA level in Isreco1 cells, and binding studies confirmed the expression of bombesin/GRP-subtype receptors (Kd = 0.42 nM; Bmax = 18,000 sites/cell). Exposure to bombesin resulted in an increase of intracellular calcium concentrations. Bombesin (1 nM) induced cell spreading at 24 h (21.7+/-1.6% versus 6.4+/-0.8% in control cells; P<0.01) and markedly increased the formation of lamellipodia. In addition, adhesion of Isreco1 cells to collagen I-coated culture dishes was stimulated in the presence of 1 nM bombesin (69+/-6% versus 42+/-1% in control cells; P<0.01). Finally, bombesin significantly increased [3H]thymidine uptake by Isreco1 cells in a dose-dependent manner, with a first significant response at 0.1 nM and a maximal effect at 100 nM bombesin (192.2+/-9.7% of control). These results clearly indicate that bombesin exerts morphological, adhesive, and proliferative effects on Isreco1 cells, suggesting that expression of the bombesin/GRP-R may contribute to the malignant properties of colon carcinoma cells.  (+info)

Telomeric repeats on small polydisperse circular DNA (spcDNA) and genomic instability. (8/11349)

Small polydisperse circular DNA (spcDNA) is a heterogeneous population of extrachromosomal circular molecules present in a large variety of eukaryotic cells. Elevated amounts of total spcDNA are related to endogenous and induced genomic instability in rodent and human cells. We suggested spcDNA as a novel marker for genomic instability, and speculated that spcDNA might serve as a mutator. In this study, we examine the presence of telomeric sequences on spcDNA. We report for the first time the appearance of telomeric repeats in spcDNA molecules (tel-spcDNA) in rodent and human cells. Restriction enzyme analysis indicates that tel-spcDNA molecules harbor mostly, if not exclusively, telomeric repeats. In rodent cells, tel-spcDNA levels are higher in transformed than in normal cells and are enhanced by treatment with carcinogen. Tel-spcDNA is also detected in some human tumors and cell lines, but not in others. We suggest, that its levels in human cells may be primarily related to the amount of the chromosomal telomeric sequences. Tel-spcDNA may serve as a unique mutator, through specific mechanisms related to the telomeric repeats, which distinguish it from the total heterogeneous spcDNA population. It may affect telomere dynamics and genomic instability by clastogenic events, alterations of telomere size and sequestration of telomeric proteins.  (+info)

Trial of Neoadjuvant Chemotherapy in Locally Advanced Colon Cancer - Full Text View - ClinicalTrials.govTrial of Neoadjuvant Chemotherapy in Locally Advanced Colon Cancer - Full Text View - ClinicalTrials.gov
In patients with locally advanced colon cancer (high risk stage II and stage III), curative surgery followed by adjuvant FOLFOX-4 chemotherapy has become the standard of care. However, for 30-40% of these patients, the current curative treatment strategy of surgical excision followed by adjuvant chemotherapy fails either to clear locoregional spread or to eradicate distant micrometastases, leading to disease recurrence. Preoperative chemotherapy is an attractive concept for locally advanced colon cancer and has the potential to impact upon both of these causes of failure. Optimum systemic therapy at the earliest possible opportunity may be more effective at eradicating distant metastases than the same treatment given after the delay and immunological stress of surgery. Added to this, shrinking the primary tumor before surgery may reduce the risk of incomplete surgical excision, and the risk of tumor cell shedding during surgery.. ECKINOXE is a multicenter randomized phase II trial designed to ...
https://clinicaltrials.gov/ct2/show/NCT01675999?recr=Open&intr=chemotherapy&rank=3
Trial of Neoadjuvant Chemotherapy in Locally Advanced Colon Cancer - Full Text View - ClinicalTrials.govTrial of Neoadjuvant Chemotherapy in Locally Advanced Colon Cancer - Full Text View - ClinicalTrials.gov
In patients with locally advanced colon cancer (high risk stage II and stage III), curative surgery followed by adjuvant FOLFOX-4 chemotherapy has become the standard of care. However, for 30-40% of these patients, the current curative treatment strategy of surgical excision followed by adjuvant chemotherapy fails either to clear locoregional spread or to eradicate distant micrometastases, leading to disease recurrence. Preoperative chemotherapy is an attractive concept for locally advanced colon cancer and has the potential to impact upon both of these causes of failure. Optimum systemic therapy at the earliest possible opportunity may be more effective at eradicating distant metastases than the same treatment given after the delay and immunological stress of surgery. Added to this, shrinking the primary tumor before surgery may reduce the risk of incomplete surgical excision, and the risk of tumor cell shedding during surgery.. ECKINOXE is a multicenter randomized phase II trial designed to ...
https://clinicaltrials.gov/ct2/show/NCT01675999?term=colon+cancer&recr=Open&rank=7
Molecular mechanisms of econazole-induced toxicity on human colon cancer cells: G0/G1 cell cycle arrest and caspase 8...
TY - JOUR. T1 - Molecular mechanisms of econazole-induced toxicity on human colon cancer cells. T2 - G0/G1 cell cycle arrest and caspase 8-independent apoptotic signaling pathways. AU - Ho, Yuan Soon. AU - Wu, Chih Hsiung. AU - Chou, Hsiao Min. AU - Wang, Ying Jan. AU - Tseng, How. AU - Chen, Chien Ho. AU - Chen, Li Ching. AU - Lee, Chia Hwa. AU - Lin, Shyr Yi. PY - 2005/10. Y1 - 2005/10. N2 - Econazole (Eco), a potent broad-spectrum anti-fungal agent, has been used in the treatment of superficial mycosis. Eco is a store-operated Ca2+ channel antagonist which induces cytotoxic cell death of leukemia. However, little is known about its cytotoxic effect upon solid tumor cells. The purpose of this study is to investigate both the in vitro and in vivo molecular mechanisms of Eco-induced toxicity on colon cancer cells. We used COLO 205 cell line and nude mice xenograft model to investigate the cytotoxic effect of Eco. We demonstrated that lower doses Eco (5-20 μM) arrested human colon cancer cells ...
https://tmu.pure.elsevier.com/en/publications/molecular-mechanisms-of-econazole-induced-toxicity-on-human-colon
Colon Cancer Treatment In Mumbai, Colon Cancer Treatment Cost, Find Best Reviewed Hospitals & Surgeons, Reviews | PractoColon Cancer Treatment In Mumbai, Colon Cancer Treatment Cost, Find Best Reviewed Hospitals & Surgeons, Reviews | Practo
Colon Cancer Treatment in Mumbai. Cost of Colon Cancer Treatment in Mumbai, View List of Best Reviewed Hospitals & Surgeons & Book Appointment, Patient Reviews, Colon Cancer Treatment Meaning, Risks, Side Effects & FAQ. | Practo
https://www.practo.com/mumbai/colon-cancer-treatment/procedure
Screening for the antiproliferative activity of extracts of marine invertebrates on human colon cancer cell linesScreening for the antiproliferative activity of extracts of marine invertebrates on human colon cancer cell lines
Screening for the antiproliferative activity of extracts of marine invertebrates on human colon cancer cell lines Conference Poster 2016 ...
http://research.umh.es/vivo/individual?uri=http%3A%2F%2Fresearch.umh.es%2Fvivo%2Fpub%2Fcomunicacion%2F169576
Mucin production by human colonic carcinoma cells correlates w...Mucin production by human colonic carcinoma cells correlates w...
Mucin production by human colonic carcinoma cells correlates with their metastatic potential in animal models of colon cancer metastasis.: Patients with mucinou
https://www.mysciencework.com/publication/show/mucin-production-by-human-colonic-carcinoma-cells-correlates-with-their-metastatic-potential-in-animal-models-of-colon-cancer-metastasis
AID 86084 - In vitro cytotoxicity against human colon adenocarcinoma cell line HT-29 at 5.9*10e-5M - PubChemAID 86084 - In vitro cytotoxicity against human colon adenocarcinoma cell line HT-29 at 5.9*10e-5M - PubChem
BioAssay record AID 86084 submitted by ChEMBL: In vitro cytotoxicity against human colon adenocarcinoma cell line HT-29 at 5.9*10e-5M.
https://pubchem.ncbi.nlm.nih.gov/bioassay/86084
Berberine reduces cAMP-induced chloride secretion in T84 human colonic carcinoma cells through inhibition of basolateral KCNQ1...Berberine reduces cAMP-induced chloride secretion in T84 human colonic carcinoma cells through inhibition of basolateral KCNQ1...
Two Grants Received to Combat Advanced Colon Cancer in Ward 5Two Grants Received to Combat Advanced Colon Cancer in Ward 5
The American Cancer Society and the Cigna Foundation have awarded $232,000 to MedStar Washington Hospital Center to address advanced colon cancer.
https://www.medstarwashington.org/news/2017/03/23/colon-cancer-prevention-ward-5/?newstag=colon-cancer-prevention
Genes May Determine Aspirins Effect on Advanced Colon Cancer, Harvard School of Public Health Study | BioSpaceGenes May Determine Aspirins Effect on Advanced Colon Cancer, Harvard School of Public Health Study | BioSpace
Genes May Determine Aspirins Effect on Advanced Colon Cancer, Harvard School of Public Health Study - read this article along with other careers information, tips and advice on BioSpace
https://www.biospace.com/article/genes-may-determine-aspirin-s-effect-on-advanced-colon-cancer-harvard-school-of-public-health-study-/
Colon Cancer Treatment Lakeville MN - Colon Cancer, Lakeville MN cancer clinics, Lakeville MN healthy diet, Lakeville MN ...
This page provides useful content and local businesses that can help with your search for Colon Cancer Treatment. You will find helpful, informative articles about Colon Cancer Treatment, including Colon Cancer. You will also find local businesses that provide the products or services that you are looking for. Please scroll down to find the local resources in Lakeville, MN that will answer all of your questions about Colon Cancer Treatment.
http://localmarket.energytimes.com/_Lakeville_MN-p1574530-Lakeville_MN.html
Colon Cancer Treatment Carson City NV - Colon Cancer, Carson City NV cancer clinics, Carson City NV healthy diet, Carson City...
This page provides useful content and local businesses that can help with your search for Colon Cancer Treatment. You will find helpful, informative articles about Colon Cancer Treatment, including Colon Cancer. You will also find local businesses that provide the products or services that you are looking for. Please scroll down to find the local resources in Carson City, NV that will answer all of your questions about Colon Cancer Treatment.
http://localmarket.energytimes.com/_Carson_City_NV-p1574530-Carson_City_NV.html
Colon Cancer Treatment Cost in India | Colon Cancer Treatment in India | Vaidam.comColon Cancer Treatment Cost in India | Colon Cancer Treatment in India | Vaidam.com
Colon Cancer Treatment cost in India starts from USD 7000. Find affordable packages, best specialists, hospitals and patient experiences for Colon Cancer Treatment in India through Vaidam.
https://www.vaidam.com/cost/colon-cancer-treatment-cost-in-india-cost-in-india
Sarcoidosis imitating metastatic colon carcinoma | SFEBES2019
We believe this is the first case report of anunusual presentation of hypercalcemia due to sarcoidosis mimicking metastatic colon carcinoma. A 68 year old lady with a background history of pancolectomy and neoadjuvant chemotherapy for Duke C1 rectal carcinoma under surveillance, ulcerative colitis, type 2 diabetes mellitus presented to the clinic with hypercalcemia with low parathyroid hormone (PTH) and symptoms of tiredness. Her blood test showed Adj Ca of 2.8 mmol/l, PTH , 2.5 pmol/l, Vitamin D 18 mol/l, ALP 177 U/l. She was commenced on 800 IU of vitamin D, ordered for bone scan, 24 h urine calcium excretion ratio, myeloma screen. Her surveillance CT scan couple of months earlier was reported stable features. She had an acute medical admission with unsteadiness of gait, tiredness and nausea. The adjusted calcium level was reported as 3.6 mmol/l with suppressed PTH. She was resuscitated with intravenous fluids and bisphosphate infusion. A CT scan of abdomen, chest and pelvis was organised that ...
https://www.endocrine-abstracts.org/ea/0065/ea0065p113
Extracorporeal immunoadsorption of plasma from a metastatic colon carcinoma patient by protein A-containing nonviable...Extracorporeal immunoadsorption of plasma from a metastatic colon carcinoma patient by protein A-containing nonviable...
A patient with a metastatic colon carcinoma was treated by immunoadsorption (IA) therapy using heat-killed, formalin-stabilized protein A-containing Staphylococcus aureus Cowan I as the immunoadsorbent. The patient experienced both subjective and objective positive clinical response without undue morbidity. The patients response correlated well with laboratory findings of decreased concentrations of carcinoembryonic antigen (CEA), immunoglobulin G (IgG), immune complexes (IC) and histopathologic data. The patient underwent surgery following 15 IA treatments; she lived for eighteen months, post-treatment.
https://www.semanticscholar.org/paper/Extracorporeal-immunoadsorption-of-plasma-from-a-m-Ray-Idiculla/ef76a038f06eb3f0e131d2b6f2e69b5b4854cb70
Frontiers | DNA Methylation and Hydroxymethylation in Primary Colon Cancer and Synchronous Hepatic Metastasis | GeneticsFrontiers | DNA Methylation and Hydroxymethylation in Primary Colon Cancer and Synchronous Hepatic Metastasis | Genetics
Colon cancer is one of the most frequent solid tumor and simultaneous diagnosis of primary colon cancer and liver metastases occurs in about one fourth of cases. The current knowledge on epigenetic signatures, especially those related to hydroxymethylation in primary cancer tissue, synchronous metastasis and blood circulating cells is lacking. This study aimed to investigate both methylcytosine (mCyt) and hydroxymethylcytosine (hmCyt) status in the DNA of individual patients from colon cancer tissue, synchronous liver metastases, and in cancer-free colon and liver tissues and leukocytes. Patients undergoing curative surgery (n=16) were enrolled and their laboratory and clinical history data collected. The contents of mCyt and hmCyt were determined by a liquid chromatography/mass spectrometry (LC/MS/MS) method in DNA extracted from primary colon cancer, synchronous hepatic metastatic tissues and homologous cancer-free tissues, i.e., colon and liver tissues as well as leukocytes. The mCyt and hmCyt
https://www.frontiersin.org/articles/10.3389/fgene.2017.00229/full
Biomarker Predicts Which Stage II Colon Cancer Patients May Benefit from Chemotherapy - Columbia University Medical CenterBiomarker Predicts Which Stage II Colon Cancer Patients May Benefit from Chemotherapy - Columbia University Medical Center
Researchers have identified a biomarker that predicts which stage II colon cancer patients may benefit from adjuvant chemotherapy.
http://newsroom.cumc.columbia.edu/blog/2016/01/20/biomarker-predicts-which-stage-ii-colon-cancer-patients-may-benefit-from-chemotherapy/
Wnt3a expression is associated with epithelial-mesenchymal transition and promotes colon cancer progression | Journal of...Wnt3a expression is associated with epithelial-mesenchymal transition and promotes colon cancer progression | Journal of...
Epithelial-mesenchymal transition (EMT) contributes to the progression and metastasis of cancer cells and is associated with a more invasive phenotype of cancer. The Wnt/β-catenin signaling pathway is one of the major pathways involved in EMT regulation. Many studies provide evidence that β-catenin, the key regulator of the canonical Wnt signaling pathway, is important in regulating EMT in cancer. However, the roles of Wnt3a, the representative canonical Wnt ligand, in EMT and colon cancer progression have not yet been fully explored. The expression levels of Wnt3a and EMT-associated proteins (E-cadherin, vimentin, and β-catenin) were assessed by immunohistochemistry in human colon cancer tissues to evaluate the clinicopathological significance of Wnt3a, as well as the correlation between Wnt3a and EMT. We then upregulated Wnt3a expression in HCT116 colon cancer cells, established a nude mouse xenograft model, detected the expression of EMT and Wnt/β-catenin signaling-associated proteins, and
https://jeccr.biomedcentral.com/articles/10.1186/s13046-014-0107-4/figures/2
Single-dose versus fractionated radioimmunotherapy of human colon carcinoma xenografts using <sup>131</sup>I-labeled...
TY - JOUR. T1 - Single-dose versus fractionated radioimmunotherapy of human colon carcinoma xenografts using 131I-labeled multivalent CC49 single-chain Fvs1. AU - Goel, A.. AU - Augustine, S.. AU - Baranowska-Kortylewicz, Janina. AU - Colcher, D.. AU - Booth, B. J M. AU - Pavlinkova, G.. AU - Tempero, M.. AU - Batra, Surinder Kumar. PY - 2001/2/12. Y1 - 2001/2/12. N2 - The prospects of radiolabeled antibodies in cancer detection and therapy remain promising. However, efforts to achieve cures, especially of solid tumors, with the systemic administration of radiolabeled monoclonal antibodies (MAbs) have met with limited success. Using genetic engineering techniques, MAbs have been tailored to improve the therapeutic index (tumor:normal tissue ratio) in clinical radioimmunotherapy. In the present study, we investigated the potential of tetravalent {[sc(Fv)2]2} and divalent [sc(FV)2] single chain Fvs of MAb CC49 for therapy in athymic mice bearing s.c. LS-174T human colon carcinoma xenografts. Mice ...
https://nebraska.pure.elsevier.com/en/publications/single-dose-versus-fractionated-radioimmunotherapy-of-human-colon
Completion of therapy by medicare patients with stage III colon cancer<...Completion of therapy by medicare patients with stage III colon cancer<...
TY - JOUR. T1 - Completion of therapy by medicare patients with stage III colon cancer. AU - Dobie, Sharon A.. AU - Baldwin, Laura Mae. AU - Dominitz, Jason A.. AU - Matthews, Barbara. AU - Billingsley, Kevin. AU - Barlow, William. PY - 2006/5/3. Y1 - 2006/5/3. N2 - Background: Certain factors, such as race or age, are known to be associated with variation in initiation of adjuvant chemotherapy for stage III colon cancer, but little is known about what factors are associated with completion of adjuvant therapy. To determine whether predictors of initiation also predict completion, we analyzed Surveillance, Epidemiology, and End Results (SEER) program data linked to Medicare claims. We investigated mortality as a means to testing the validity of the completion measure that we created. Methods: We studied 3193 stage III colon cancer patients whose diagnosis was recorded in 1992-1996 SEER program data linked to 1991-1998 Medicare claims and who initiated adjuvant chemotherapy after colon cancer ...
https://ohsu.pure.elsevier.com/en/publications/completion-of-therapy-by-medicare-patients-with-stage-iii-colon-c-2
Amplification and Elevated Expression of C-Myc in a Chemically Induced Mouse Colon Tumor<...Amplification and Elevated Expression of C-Myc in a Chemically Induced Mouse Colon Tumor<...
TY - JOUR. T1 - Amplification and Elevated Expression of C-Myc in a Chemically Induced Mouse Colon Tumor. AU - Yander, Gail. AU - Halsey, Heidi. AU - Kenna, Margaret. AU - Augenlicht, Leonard H.. PY - 1985/9. Y1 - 1985/9. N2 - The amplification and level of expression of four cellular oncogenes was investigated in dimethylhydrazine-induced Mouse Colon Tumor 36 of Corbett et al. [Corbett, T. H. Griswold, D. P., Jr., Roberts, B. J., Peckham, J. C., and Schabel, F. M., Jr. Cancer (Phila.), 40:2660-2680,1977], which has been used to evaluate potential chemotherapeutic agents. A 30- to 40-fold amplification of c-myc was observed in the tumor DNA as compared to the DNA of normal colonic mucosa and liver. No changes were observed in the number of copies of c-mos, erbP, or bas. Digestion with three different restriction enzymes demonstrated that there was no major alteration in the genomic structure of c-myc in the amplified DNA. The level of c-rnyc RNA was 10-fold higher in both the total and ...
https://einstein.pure.elsevier.com/en/publications/amplification-and-elevated-expression-of-c-myc-in-a-chemically-in-2
Better survival in right-sided versus left-sided stage I - III colon cancer patients | BMC Cancer | Full TextBetter survival in right-sided versus left-sided stage I - III colon cancer patients | BMC Cancer | Full Text
Currently, data regarding the prognosis of right-sided versus left-sided colon cancer are conflicting, however, most studies revealed a poorer survival in right-sided primary tumor location [14-18, 29].. To our knowledge this is the first population-based, propensity score adjusted analysis investigating the prognostic impact of tumor location in non-metastatic colon cancer patients. Being aware of the conflicting data and also of the challenges to handle relevant bias due to substantial imbalances regarding baseline characteristics between right- and left-sided colon cancer patients, we have intentionally selected the propensity score matching as a further statistical method in addition to common multivariate analysis to minimize confounding. In the present analysis, the cohort was partitioned into subgroups containing one or more patients with right-sided colon cancer who were matched to one or more patients with left-sided colon cancer with similar values on the observed covariates in the ...
https://bmccancer.biomedcentral.com/articles/10.1186/s12885-016-2412-0
Identification of Endogenous Inhibitory Growth Factors from a Human Colon Carcinoma Cell Line<...
TY - JOUR. T1 - Identification of Endogenous Inhibitory Growth Factors from a Human Colon Carcinoma Cell Line. AU - Levine, Alan E.. AU - McRae, L. J.. AU - Hamilton, David A.. AU - Brattain, Diane E.. AU - Yeoman, Lynn C.. AU - Brattain, Michael G.. PY - 1985/5/1. Y1 - 1985/5/1. N2 - A line of human colon carcinoma cells, designated MOSER, was established which synthesized tumor-inhibitory factor (TIF) and transforming growth factor (TGF) activity. Both activities were found in serum-free conditioned medium and in cell extracts. The activities coelute on Bio-Gel P-10 in acetic acid, but can be completely separated by reverse-phase high-pressure liquid chromatography. The TIF and TGF activities were acid and heat stable and were sensitive to trypsin and dithiothreitol. MOSER cell TIF prevented the anchorage-independent growth of the more differentiated colon carcinoma cell lines tested but did not affect the less differentiated lines. Using anchorage-dependent growth conditions, the effect of ...
https://experts.nebraska.edu/en/publications/identification-of-endogenous-inhibitory-growth-factors-from-a-hum
CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix...CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix...
2018 American Association for Cancer Research. Unresectable hepatic metastases of colon cancer respond poorly to existing therapies and are a major cause of colon cancer lethality. In this study, we evaluated the therapeutic viability of targeting the mediator kinase CDK8, an early clinical stage drug target, as a means to suppress metastasis of colon cancer. CDK8 was amplified or overexpressed in many colon cancers and CDK8 expression correlated with shorter patient survival. Knockdown or inhibition of CDK8 had little effect on colon cancer cell growth but suppressed metastatic growth of mouse and human colon cancer cells in the liver. This effect was due in part to inhibition of already established hepatic metastases, indicating therapeutic potential of CDK8 inhibitors in the metastatic setting. In contrast, knockdown or inhibition of CDK8 had no significant effect on the growth of tumors implanted subcutaneously, intrasplenically, or orthotopically in the cecum. CDK8 mediated colon cancer ...
http://scholars.uab.edu/display/pub2301026
Growth-regulatory effect of gastrin on human colon cancer cell lines is determined by protein kinase a isoform contentGrowth-regulatory effect of gastrin on human colon cancer cell lines is determined by protein kinase a isoform content
Cell growth is regulated by various peptide growth factors through receptor-linked multiple intracellular signal-transduction pathways, such as the cyclic adenosine monophosphate (cAMP) pathway. cAMP activates cAMP-dependent protein kinase A (PKA) either to stimulate or inhibit cell growth. The effe …
https://pubmed.ncbi.nlm.nih.gov/7800859/?dopt=Abstract
CCR1-mediated accumulation of myeloid cells in the liver microenvironment promoting mouse colon cancer metastasisCCR1-mediated accumulation of myeloid cells in the liver microenvironment promoting mouse colon cancer metastasis
To understand colon cancer metastasis, we earlier analyzed a mouse model that developed liver metastasis of cancer cells disseminated from the spleen. We suggested that CCR1(+) bone marrow (BM)-derived cells are recruited to the microenvironment of disseminated colon cancer cells, and produce metall …
https://pubmed.ncbi.nlm.nih.gov/25326065/?dopt=Abstract
An on-going clinical trial frees a woman from advanced colon cancer | BioSkyAn on-going clinical trial frees a woman from advanced colon cancer | BioSky
A 50-year old woman who suffered from colon cancer that had spread to her lungs is now free from cancer following a clinical trial using her own white blood cells.. Her remarkable recovery was recently published in the New England Journal of Medicine. Before treatment, the patient had 7 tumors in her lungs. 40 days following treatment, all 7 of her lung metastases had shrunk. At a 9-month follow up, one of the tumors appeared to have started to develop resistance to the treatment, although it was successfully removed by surgery. The patient has since remained cancer free. No adverse side effects were reported.. Her cancer cells contained a mutation in a gene called KRAS, which is very common in cancers such as colorectal and pancreatic cancers. Cancers with this mutation generally have a poor prognosis, and previous attempts by scientists to target this mutation had been unsuccessful. This study marks the first successful attempt to target this KRAS mutation in a cancer.. Essentially, the ...
https://biosky.co/clinical-trial-treatment-colon-cancer/
Pesquisa | Portal Regional da BVSPesquisa | Portal Regional da BVS
BACKGROUND: Circular RNAs (circRNAs) are considered to be highly stable due to the closed structure, which are predominately correlated with the development and progression of a wide variety of cancers. Colon cancer is one of the most common malignancies worldwide. A recent study demonstrated the upregulated expression of circPIP5K1A in non-small cell lung cancer. However, few studies have investigated the relationship between circ_0014130 level and colon cancer. Therefore, elucidating the underlying mechanisms of circPIP5K1As role may help with the identification of novel diagnostic and therapeutic targets for colon cancer. AIM: To investigate the status of circPIP5K1A in colon cancers and its effects on the modulation of cancer development. METHODS: The expression level of circPIP5K1A in tissue and serum samples from colon cancer patients, as well as human colonic cancer cell lines was detected by real-time quantitative reverse transcription-polymerase chain reaction. Following the ...
https://pesquisa.bvsalud.org/portal/?lang=pt&q=au:%22Zhang,%20Qu%22
Plus itPlus it
4334 Vascular endothelial growth factor (VEGF) has been shown to be associated with tumor angiogenesis and poor prognosis in human colon cancer. VEGF receptor-1 (VEGFR-1/Flt-1) is a high-affinity receptor for VEGF and is typically viewed as being endothelial cell specific. Here we report on the expression and function of VEGFR-1 on colon cancer cell lines. VEGFR-1 was expressed in 7/7 colon cancer cell lines as determined by Western blot analysis. Treatment of the human colon cancer cell line SW480 with VEGF-A (ligand for both VEGFR-1 and VEGFR-2) or VEGF-B (a ligand specific for VEGFR-1) led to activation of Erk 1/2. A blocking antibody to VEGFR-1 (18F1) completely inhibited the ability of VEGF-A and -B to activate Erk 1/2 in SW480 cells. VEGF-A and B did not increase colon cancer cell proliferation as determined by the MTT assay. However, VEGF-A and VEGF-B led to a significant induction of cancer cell motility and invasion through Matrigel. VEGF-A and -B stimulation of colon tumor cells also ...
http://cancerres.aacrjournals.org/content/64/7_Supplement/1000.4
Medical Blog by Dr. Hujimy: The Best Colon Cancer Treatment OptionsMedical Blog by Dr. Hujimy: The Best Colon Cancer Treatment Options
Colon cancer treatments are varied and you can choose from a series of traditional and alternative methods of dealing with this condition. Surgery is often the number one choice - the surgeon removes the tumors on the colon, even if the cancer cells are spread beyond the colon itself. This ensures less problems in the future of the patients life, reducing chances of bowel problems or internal bleeding. Colon cancer surgery is usually categorized in four main areas: rectum resection, radio frequency ablation, colostomy and colon resection. The surgeon will determine which method is best suited for each individual patient ...
http://our-medical.blogspot.com/2009/02/best-colon-cancer-treatment-options.html
First-Line FOLFOX4 Ups Survival in Advanced Colon Cancer | Cancer Network | The Oncology JournalFirst-Line FOLFOX4 Ups Survival in Advanced Colon Cancer | Cancer Network | The Oncology Journal
ORLANDO-Compared with the standard first-line chemotherapy treatment for advanced colorectal cancer, patients treated with the FOLFOX4 regimen containing the investigational agent oxaliplatin lived longer and had fewer side effects. 1
http://www.cancernetwork.com/articles/first-line-folfox4-ups-survival-advanced-colon-cancer
First-Line FOLFOX4 Ups Survival in Advanced Colon CancerFirst-Line FOLFOX4 Ups Survival in Advanced Colon Cancer
ORLANDO-Compared with the standard first-line chemotherapy treatment for advanced colorectal cancer, patients treated with the FOLFOX4 regimen containing the investigational agent oxaliplatin lived longer and had fewer side effects.
https://www.cancernetwork.com/view/first-line-folfox4-ups-survival-advanced-colon-cancer
Efficacy and Safety of Compound Kushen Injection on Patients with Advanced Colon Cancer: A Meta-Analysis of Randomized...Efficacy and Safety of Compound Kushen Injection on Patients with Advanced Colon Cancer: A Meta-Analysis of Randomized...
Evidence-Based Complementary and Alternative Medicine (eCAM) is an international peer-reviewed, Open Access journal that seeks to understand the sources and to encourage rigorous research in this new, yet ancient world of complementary and alternative medicine.
https://www.hindawi.com/journals/ecam/2017/7102514/
Alternative Colon Cancer Treatments | New Hope UnlimitedAlternative Colon Cancer Treatments | New Hope Unlimited
Colon cancer is the second leading cause of cancer death in men and women. New Hope Unlimiteds alternative colon cancer treatment consists of a non-invasive, less toxic and more effective treatment strategy that improves the symptoms and reverse the disease. Know your options and call us at 480-845-0813.
https://www.newhopemedicalcenter.com/colon-cancer/
Colorectal Cancer ( Colon Cancer ) Treatment in Spain: Costs, Doctors, and top Hospitals | MediGenceColorectal Cancer ( Colon Cancer ) Treatment in Spain: Costs, Doctors, and top Hospitals | MediGence
Find out more about Colorectal Cancer ( Colon Cancer ) Treatment in Spain. Costs, Treatments, and Prioritized Appointments with best Doctors at top JCI-Certified Hospitals
https://medigence.com/hospitals/oncology/colorectal-cancer/spain
北京大学医学部机构知识库([email protected]): The COX-2 selective inhibitor-independent COX-2 effect on colon carcinoma cells is associated with the...
Background Cyclooxygenase-2 (COX-2) is a key factor in the development of colorectal cancer, and non-steroidal anti-inflammatory drugs (NSAIDs) have anti-colorectal cancer activity. However, the potential molecular mechanism of the COX-2 selective inhibitor effect on proliferation and apoptosis of colon cancer cells is unclear. In this study, we have demonstrated for the first time that the Delta1/Notch1 signal transduction pathway mediates the COX-2 selective inhibitor effect on colorectal cancer cells, and we reveal the mechanism of the Notch1 pathway in terms of regulating the proliferation and apoptosis of colorectal cancer cells. Methods and Result Colon cancer cell lines HT-29 and SW480 were treated with NS-398 (a COX-2 selective inhibitor) and DAPT (a gamma-secretase inhibitor). The colormetric MTT cell proliferation assay and flow cytometry were used to measure cell proliferation and apoptosis. Reverse transcriptase (RT)-PCR and ELISA analyses were used to detect the levels of COX-2 mRNA ...
http://ir.bjmu.edu.cn/handle/400002259/62350
RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells<...RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells<...
TY - JOUR. T1 - RACK1 downregulates levels of the pro-apoptotic protein Fem1b in apoptosis-resistant colon cancer cells. AU - Subauste, M. Cecilia. AU - Ventura-Holman, T.. AU - Du, L.. AU - Subauste, Jose S.. AU - Chan, Shing Leng. AU - Yu, Victor C.. AU - Maher, Joseph F.. PY - 2009/12/1. Y1 - 2009/12/1. N2 - Evasion of apoptosis plays an important role in colon cancer progression. Following loss of the Apc tumor suppressor gene in mice, the gene encoding Fem1b is upregulated early in neoplastic intestinal epithelium. Fem1b is a pro-apoptotic protein that interacts with Fas, TNFR1 and apaf-1, and increased expression of Fem1b induces apoptosis of cancer cells. Fem1b is a homolog of FeM-1, a protein in Caenorhabditis elegans that is negatively regulated by ubiquitination and proteasomal degradation. To study Fem1b regulation in colon cancer progression, we used apoptotis-sensitive SW480 cells, derived from a primary colon cancer, and their isogenic, apoptosis-resistant counterparts sW620 cells, ...
https://scholars.uthscsa.edu/en/publications/rack1-downregulates-levels-of-the-pro-apoptotic-protein-fem1b-in-
Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream...Survival advantages conferred to colon cancer cells by E-selectin-induced activation of the PI3K-NFκB survival axis downstream...
BACKGROUND: Extravasation of circulating cancer cells is a key event of metastatic dissemination that is initiated by the adhesion of cancer cells to endothelial cells. It requires interactions between adhesion receptors on endothelial cells and their counter-receptors on cancer cells. Notably, E-selectin, a major endothelial adhesion receptor, interacts with Death receptor-3 present on metastatic colon carcinoma cells. This interaction confers metastatic properties to colon cancer cells by promoting the adhesion of cancer cells to endothelial cells and triggering the activation of the pro-migratory p38 and pro-survival ERK pathways in the cancer cells. In the present study, we investigated further the mechanisms by which the E-selectin-activated pathways downstream of DR3 confer a survival advantage to colon cancer cells.. METHODS: Cell survival has been ascertained by using the WST-1 assay and by evaluating the activation of the PI3 kinase/NFκB survival axis. Apoptosis has been assayed by ...
https://read.qxmd.com/read/21722370/survival-advantages-conferred-to-colon-cancer-cells-by-e-selectin-induced-activation-of-the-pi3k-nf%C3%AE%C2%BAb-survival-axis-downstream-of-death-receptor-3
Colon Cancer Treatment (Patient): Healthwise Medical Information on eMedicineHealthColon Cancer Treatment (Patient): Healthwise Medical Information on eMedicineHealth
Learn about Colon Cancer Treatment (Patient). Information from PDQ, the National Cancer Institutes comprehensive cancer information database.
https://www.emedicinehealth.com/colon_cancer_treatment_patient-health/article_em.htm
Quantification of Intracellular Phosphorylated Carbohydrates in HT29 Human Colon Adenocarcinoma Cell Line Using Liquid...Quantification of Intracellular Phosphorylated Carbohydrates in HT29 Human Colon Adenocarcinoma Cell Line Using Liquid...
Close The Infona portal uses cookies, i.e. strings of text saved by a browser on the users device. The portal can access those files and use them to remember the users data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser. ...
https://www.infona.pl/resource/bwmeta1.element.acs-doi-10_1021_ac070170v
Colon Cancer treatments. Survival, toxicity, side effects. Chemotherapy. Melbourne, Australia
Cancer Monthly. Colon Cancer treatments. Chemotherapy. Monash University, Melbourne, Australia. Compare therapy differences, longest survival rates, toxicity, side effects, hospitals.
http://www.cancermonthly.com/TreatmentInfo.asp?TreatmentID=1137&returnURL=SearchResults.asp%3FCurrentPage%3D145
Colon Cancer treatments. Survival, toxicity, side effects. Chemotherapy. Barcelona, Spain
Cancer Monthly. Colon Cancer treatments. Chemotherapy. Universitat Aut noma de Barcelona, Barcelona, Spain. Compare therapy differences, longest survival rates, toxicity, side effects, hospitals.
http://www.cancermonthly.com/TreatmentInfo.asp?TreatmentID=1898&returnURL=SearchResults.asp%3FCurrentPage%3D98
Chemopreventive effects of dietary canola oil on colon cancer development - Dieting Blog
It is pertinent however to determine wholesome cooking strategies in addition to consuming habits in methods to not intervene with the nutritious worth of meals Mother Nature intended. Have you ever ever gone through a grueling weight reduction program for a very long time, solely to seek out out later that youve hit a wall when it comes to outcomes. You wont end up tempted almost as much if your forbidden foods arent simply accessible. Correctly, chances are youll need to do additional than merely discovering a meals plan reply program. He did it greater than 50 years earlier. One factor to remember when deciding how one can go about shedding pounds is that there is no such thing as a single greatest way to lose weight. This can be a weight loss program thats loaded with numerous greens and fruits, chemopreventive effects of dietary canola oil on colon cancer development with the lean meats and likewise other protein sources. Due to this actuality, it is best to avoid excessive consumption ...
http://partykleider.info/dietary/chemopreventive-effects-of-dietary-canola-oil-on-colon-cancer-development.html
Oncotype DX Predicts Recurrence Risk in Stage II and Stage III Colon Cancer - UNM Comprehensive Cancer CenterOncotype DX Predicts Recurrence Risk in Stage II and Stage III Colon Cancer - UNM Comprehensive Cancer Center
Among patients with Stage II or Stage III colon cancer, the Oncotype DX colon cancer test provides information about risk of cancer recurrence and may help guide treatment decisions. These results were presented at the 2012 Annual Meeting of the American Society of Clinical Oncology.. Gene expression profiling explores the patterns of genes that are active in tumor cells. Studies suggest that gene expression may provide important information about prognosis or likely response to treatment in several types of cancer. For example, among women with early-stage, estrogen receptor-positive breast cancer, the Oncotype DX breast cancer test has been shown to predict the likelihood of cancer recurrence and the likelihood of benefit from chemotherapy. As a result, the test has been added to medical guidelines for early-stage breast cancer.. A similar test became available for colon cancer patients in 2010. The test was originally developed for use in patients with Stage II colon cancer, but has now also ...
http://cancer.unm.edu/2012/06/11/oncotype-dx-predicts-recurrence-risk-in-stage-ii-and-stage-iii-colon-cancer/
Colon cancer treatment in clinics of Anyang, prices, patient reviews - DocLandmedColon cancer treatment in clinics of Anyang, prices, patient reviews - DocLandmed
➤ Colon cancer treatment in clinics of Anyang, ➤ 16 clinics, Addresses, $ Prices for treatments and diagnostics, ☺ 43 reviews, ✎ Make an appointment, ✉ 3,439 patients are sent for treatment
https://doclandmed.com/en/south-korea/anyang/oncology/colon-cancer
A derived neutrophil to lymphocyte ratio predicts clinical outcome in stage II and III colon cancer patients | British Journal...A derived neutrophil to lymphocyte ratio predicts clinical outcome in stage II and III colon cancer patients | British Journal...
Inflammation has a critical role in the pathogenesis and progression of cancer. Recently, the derived neutrophil to lymphocyte ratio (absolute count of neutrophils divided by the absolute white cell count minus the absolute count of neutrophils; dNLR) has been shown to influence clinical outcome in various cancer entities. In this study, we analysed the dNLR with clinical outcome in stage II and III colon cancer patients. Three-hundred and seventy-two patients with stage II and III colon cancer were included in this retrospective study. Kaplan-Meier curves and multivariate Cox proportion analyses were calculated for time to recurrence (TTR) and overall survival (OS). In univariate analysis, the elevated preoperative dNLR was significantly associated with decreased TTR (hazard ratio (HR) 2.38, 95% confidence interval (CI) 1.57-3.6, P|0.001) and remained significant in multivariate analysis. Patients with dNLR |3 had a median TTR of 83 months, and patients with dNLR ⩽3 showed a median TTR of 132 months.
https://www.nature.com/articles/bjc2013346?error=cookies_not_supported&code=618ffa1b-1e95-4c13-aaca-0f47dec1be78
Colon Cancer - Prevention Tips - LuxeBin
Before talking about colon cancer prevention, lets talk a little about what colon cancer is, exactly. Both the colon and rectum are part of the digestive system. The first part of the digestive system, which is the esophagus and stomach, breaks down food to be processed into energy. Next, the broken down food travels to the small intestine/bowel, which is a narrow, 20-foot section that continues breaking down food and absorbing most of the nutrients. The small intestine then sends the remaining material to the five-foot-long colon (which is also referred to as the large intestine), where it absorbs salt and water and stores waste. The first part of the colon is the ascending colon, which is attached to the small intestine and the appendix on the right side of the abdomen. The transverse colon runs from the right to the left side of the upper abdomen. The descending colon travels downward on the left side and the sigmoid colon is an S-shaped portion that passes food matter down to the rectum, ...
http://luxebin.com/colon-cancer-prevention-tips/
Cancers | Free Full-Text | Complex of MUC1, CIN85 and Cbl in Colon Cancer Progression and MetastasisCancers | Free Full-Text | Complex of MUC1, CIN85 and Cbl in Colon Cancer Progression and Metastasis
We previously reported that CIN85, an 85 KDa protein known to be involved in tumor cell migration and metastasis through its interaction with Cbl, associates with MUC1 in tumor cells. MUC1/CIN85 complex also regulates migration and invasion of tumor cells in vitro. Here, we examined specifically human colon carcinoma tissue microarrays (TMA) by immunohistochemistry for the expression of MUC1 and CIN85 and their potential role in cancer progression and metastasis. We detected a significant increase in expression of both MUC1 and CIN85 associated with advanced tumor stage and lymph node metastasis. We further investigated if Cbl could also be present in the MUC1/CIN85 complex. Co-immunoprecipitation assay showed that Cbl co-localized both with CIN85 and with MUC1 in a human colon cancer cell line. To begin to investigate the in vivo relevance of MUC1 overexpression and association with CIN85 and Cbl in cancer development and progression, we used human MUC1 transgenic mice that express MUC1 on the colonic
http://www.mdpi.com/2072-6694/7/1/342
PTH-related protein enhances LoVo colon cancer cell proliferation, adhesion, and integrin expression<...PTH-related protein enhances LoVo colon cancer cell proliferation, adhesion, and integrin expression<...
TY - JOUR. T1 - PTH-related protein enhances LoVo colon cancer cell proliferation, adhesion, and integrin expression. AU - Shen, Xiaoli. AU - Falzon, Miriam. PY - 2005/2/15. Y1 - 2005/2/15. N2 - Parathyroid hormone-related protein (PTHrP) has been localized in human colon cancer tissue and cell lines. Tumor cell adhesion to extracellular matrix (ECM) proteins plays a major role in the invasion and metastasis of tumor cells, and is mediated via integrin subunits. The LoVo human colon cancer cell line was used as a model system to study the effects of PTHrP on cell proliferation and adhesion to ECM proteins found in normal liver. Clones of LoVo cells engineered to overexpress PTHrP by stable transfection with a PTHrP cDNA showed enhanced cell proliferation vs. control (empty vector-transfected) cells. PTHrP-overexpressing cells also showed significantly higher adhesion to collagen type I, fibronectin, and laminin, and enhanced expression of the ∀2, ∀5, ∀6, ∃1 and ∃4 integrin subunits. ...
https://researchexperts.utmb.edu/en/publications/pth-related-protein-enhances-lovo-colon-cancer-cell-proliferation
Inhibitory effect of emodin on human colon cancer SW620 cells and possible mechanisms | AbstractInhibitory effect of emodin on human colon cancer SW620 cells and possible mechanisms | Abstract
This study aimed to investigate the inhibitory effect of emodin on human colon cancer SW620 cells and the possible mechanisms. SW620 cells were cultur..
https://www.alliedacademies.org/abstract/inhibitory-effect-of-emodin-on-human-colon-cancer-sw620-cells-and-possible-mechanisms-9333.html
Modified complete mesocolic excision with central vascular ligation for the treatment of right-sided colon cancer: Long-term...Modified complete mesocolic excision with central vascular ligation for the treatment of right-sided colon cancer: Long-term...
TY - JOUR. T1 - Modified complete mesocolic excision with central vascular ligation for the treatment of right-sided colon cancer. T2 - Long-term outcomes and prognostic factors. AU - Cho, Min Soo. AU - Baek, Se Jin. AU - Hur, Hyuk. AU - Min, Byung Soh. AU - Baik, Seung Hyuk. AU - Kim, Namkyu. PY - 2015/4/1. Y1 - 2015/4/1. N2 - Objective: to Investigate the Long-term Oncologic Outcomes and Risk Factors for Adverse Effects in Rt.-sided Colon Cancer Patients Who Underwent Modified Complete Mesocolic Excision . Background: Complete Mesocolic Excision with Ctrl. Vasc. Ligation Has Recently Been Found to Improve Oncological Outcomes in Patients with Colon Cancer. Our Inst. Has Estab. MCME on the Basis of the Original Concept of CME for the Treatm. of Rt.-sided Colon Cancer. Methods: between January 2000 and July 2009, 773 Patients Who Underwent MCME for Rt.-sided Colon Cancer Were Eligible for This Retrospective Stud.. the Prognostic Factors for Survival/recurrence and the Risk Factors for ...
https://yonsei.pure.elsevier.com/en/publications/modified-complete-mesocolic-excision-with-central-vascular-ligati
Modulation of chemosensitivity in human colon carcinoma cells by downregulating Protein Kinase Cα expression<...
TY - JOUR. T1 - Modulation of chemosensitivity in human colon carcinoma cells by downregulating Protein Kinase Cα expression. AU - Chakrabarty, Subhas. AU - Huang, Shuang. PY - 1996/7/1. Y1 - 1996/7/1. N2 - Protein kinase C (PKC) is thought to play a role in tumor progression and drug resistance of colon carcinomas. Specifically, the PKCα isoform has been implicated in drug resistance and responsiveness of colon carcinoma cells to growth factors. Therefore, in this study we determined the effect of downregulating PKCα expression by transfecting human colon carcinoma cells with an antisense PKCα expression vector and then determined the sensitivity of these cells to the anticancer drugs mitomycin C (MMC), 5-fluorouracil (5-FU) and vincristine (Vin). Transiently transfecting the human colon carcinoma cell lines Moser, SW480 and HT29 with antisense PKCα expression vector (but not antisense PKCβ expression vector) consistently increased the sensitivity of these cells to MMC, 5-FU and VIN by ...
https://augusta.pure.elsevier.com/en/publications/modulation-of-chemosensitivity-in-human-colon-carcinoma-cells-by-
Human Colon Adenocarcinoma cell line HCA-7 - Quicktech
Cell lines are invaluable tools for biomedical research. Cancer cell lines are the foundation of cancer biology and the quest for drug treatments. Adenocarcinoma is a cancer of the epithelium (including colon) and originates in glandular tissue, such as skin surface layer and glands.. Product. These human adenocarcinoma cell lines have been previously licensed to commercial parties for research into human adenocarcinoma treatments.. These cell lines are available through Public Health England ECACC. Please make your purchase through the links below.. Imperial Innovations requests that commercial/for profit parties contact them first to discuss the terms of supply prior to Innovations authorising the release of supplies from ECACC.. ...
http://quicktech.imperialinnovations.co.uk/i/Cell_Lines/HCA7.html
Effect of Restricted Caloric Intake on Azoxymethane-induced Colon Tumor Incidence in Male F344 Rats | Cancer ResearchEffect of Restricted Caloric Intake on Azoxymethane-induced Colon Tumor Incidence in Male F344 Rats | Cancer Research
The effect of 30% caloric restriction on azoxymethane (AOM)-induced colon carcinogenesis was investigated in male F344 rats. Starting at 5 weeks of age, groups of animals were fed ad libitum a high-fat (23.5%) semipurified diet. At 7 weeks of age, all animals except the vehicle-treated groups were s.c. injected with AOM (15 mg/kg body wt, once weekly for 2 weeks). Four days after the second AOM injection, groups of animals were continued on high-fat diet and fed ad libitum (ad libitum group) whereas other groups were restricted to 70% of total calories (calorie-restricted group) consumed by the ad libitum group, but received same amounts of fiber, vitamins, and minerals. Thirty-two weeks after AOM injections, all animals were necropsied. The animals in the calorie-restricted group developed significantly fewer colon tumors and had a lower colon tumor incidence than did the rats in the ad libitum group. The size of colon tumors was also reduced in the calorie-restricted group.. ...
https://cancerres.aacrjournals.org/content/47/5/1226?ijkey=3052540f25862d99ef2fc1061e9855bcf5d928b5&keytype2=tf_ipsecsha
Quantitative analysis of the level of p53 and p21WAF1 mRNA in human colon cancer HT-29 cells treated with inositol...
The aim of this study was to analyze the molecular mechanism of inositol hexaphosphate (InsP6) action through which it may inhibit proliferation of colon cancer cells and cell cycle progression. A kinetic study of p53 and p21WAF1 mRNA increase was performed on human colon cancer HT-29 cells after treatment with 1, 5 and 10 mM InsP6 for 6, 12, 24 and 48 h. Real-time-QPCR based on TaqMan methodology was applied to analyze quantitatively the transcript levels of these genes. The transcription of β-actin and GAPDH genes was assessed in parallel to select the control gene with least variability. The 2-ΔΔCt method was used to analyze the relative changes in gene transcription. InsP6 stimulated p53 and p21WAF1 expression at the mRNA level, with the highest increase in p21WAF1 mRNA occurring at 24 h, i.e., following the highest increase in p53 mRNA observed at 12 h. Based on these studies it may be concluded that the ability of InsP6 to arrest the cell cycle may be mediated by the transcriptional ...
http://psjd.icm.edu.pl/psjd/element/bwmeta1.element.bwnjournal-article-abpv53p349kz
Human Colon Cancer Stem Cell Culture Extra-cellular Differentiation Matrix pre-coated 6 Well Plate|CelprogenHuman Colon Cancer Stem Cell Culture Extra-cellular Differentiation Matrix pre-coated 6 Well Plate|Celprogen
Human Colon Cancer Stem Cell Culture Extra-cellular Differentiation Matrix is essential for Differentiation of Human Colon Cancer Stem Cell Cultures. This product requires Human Colon Cancer Stem Cell Culture Media Cat#M36112-39 and Cells Cat# 36112-39. Also available Products ...
https://www.celprogen.com/details.php?pid=7953
Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells<...
TY - JOUR. T1 - Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells. AU - Gurbuxani, Sandeep. AU - Bruey, Jean Marie. AU - Fromentin, Annie. AU - Larmonier, Nicolas. AU - Parcellier, Arnaud. AU - Jäättelä, Marja. AU - Martin, François. AU - Solary, Eric. AU - Garrido, Carmen. N1 - Funding Information: We thank M Martin and B Bonnotte for valuable advice and M Moutet for excellent technical assistance. Our group is supported by a special grant from the Ligue Nationale. PY - 2001/11/8. Y1 - 2001/11/8. N2 - Expression of inducible heat shock protein 70 (HSP70) in tumor cells has been proposed to enhance their immunogenicity. However, HSP70 has also been demonstrated to prevent tumor cell death, a key process for the development of tumor cell immunogenicity. In the present study, we investigated the influence of the HSP70 protein level on PRO colon cancer cell growth and immunogenicity in syngeneic BDIX rats and nude mice. These cells have a basal expression ...
https://arizona.pure.elsevier.com/en/publications/selective-depletion-of-inducible-hsp70-enhances-immunogenicity-of
DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts<...
TY - JOUR. T1 - DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts. AU - Giovanella, Beppino C.. AU - Stehlin, John S.. AU - Wall, Monroe E.. AU - Wani, Mansukh C.. AU - Nicholas, Allan W.. AU - Liu, Leroy F.. AU - Silber, Robert. AU - Potmesil, Milan. N1 - Copyright: Copyright 2018 Elsevier B.V., All rights reserved.. PY - 1989. Y1 - 1989. N2 - Drug development is needed to improve chemotherapy of patients with locally advanced or metastatic colon carcinoma, who otherwise have an unfavorable prognosis. DNA topoisomerase I, a nuclear enzyme important for solving topological problems arising during DNA replication and for other cellular functions, has been identified as a principal target of a plant aLkaloid 20(S)-camptothecin. Significantly increased concentrations of this enzyme, compared to that in normal colonic mucosa, were found in advanced stages of human colon adenocarcinoma and in xenografts of colon cancer carried by immunodeficient mice. Several synthetic ...
https://tmu.pure.elsevier.com/zh/publications/dna-topoisomerase-i-targeted-chemotherapy-of-human-colon-cancer-i
Liver Resection for Metastatic Colon CarcinomaLiver Resection for Metastatic Colon Carcinoma
HPB Surgery is a peer-reviewed, Open Access journal that offers ready access to important developments in the field of HPB surgery and associated disciplines. We aim to publish fresh experimental and clinical work across the spectrum of HPB disease, while concentrating on those conditions for which surgical treatment - not necessarily an actual operation - is a common option. Thus diabetes mellitus and hepatitis, for example, might belong more appropriately elsewhere, though not if the paper should concern pancreatic transplantation or virally-induced hepatoma.
https://www.hindawi.com/journals/hpb/1989/040169/abs/
Expression of Wnt pathway components frizzled and disheveled in colon cancer arising in patients with inflammatory bowel diseaseExpression of Wnt pathway components frizzled and disheveled in colon cancer arising in patients with inflammatory bowel disease
Mutations in apc which lead to activation of the Wnt signaling pathway are a hallmark of sporadic colon cancers but occur infrequently in colon cancers arising in patients with inflammatory bowel disease (IBD). There is evidence, however, that other components of the Wnt pathway may be altered in IBD-related colon cancer. In this study, we examined the expression the Wnt pathway components frizzled (Fz), the cell surface receptor, and disheveled (DVL), a family of cytoplasmic signal transduction molecules, in IBD and IBD-related colon cancer. Paraffin sections of normal and malignant colon tissues were obtained from patients with a history of ulcerative colitis and from controls with sporadic colon cancer. Tissue sections were stained with antibodies directed against Fz1/2 receptors and DVL1, DVL2 and DVL3 and antigen expression visualized by immunohistochemistry. Fz1/2 receptors were minimally expressed in normal IBD mucosa, were not expressed in IBD colon cancer, but exhibited strong ...
https://www.spandidos-publications.com/or/18/3/691
Membrane peptidase expression by confluent cultures of Caco-2 cells -ORCAMembrane peptidase expression by confluent cultures of Caco-2 cells -ORCA
Contluent cultures of Caco-2 cells, a human colonic carcinoma cell line, undergo differentiation into enterocyte-like cells and are widely used as a model system to study the expression of membrane peptidases on the apical brush border [I-41 Indirect irnniunofluorescent staining has previously shown dipeptidylpeptidase IV (DPPIV, EC 3 4 14 5) to be homogeneously distributed on the surface of Caco-2 cells [ I ] whereas endopeptidase-24 1 1 (E-24 I I , EC 3 4 24 I I ) was found on the surface of some cells but not on others [4] This observation has also been reported by Jalal e/ d. [ S ] who have shown that E-24 1 1 is expressed by all cells but in some is confined to an intracellular pool In the present study the cellsurface and intracellular expression of five membrane peptidases on confluent cultures of Caco-2 cells has been investigated using indirect immunofluorescent staining The membrane peptidases studied were DPPIV, E-24 I I , angiotensin converting enzyme (ACE, EC 3 4 15 I). ...
http://orca-mwe.cf.ac.uk/57436/
Anticancer Effect of COX-2 Inhibitor DuP-697 Alone and in Combination with Tyrosine Kinase Inhibitor (E7080) on Colon Cancer...Anticancer Effect of COX-2 Inhibitor DuP-697 Alone and in Combination with Tyrosine Kinase Inhibitor (E7080) on Colon Cancer...
Anticancer Effect of COX-2 Inhibitor DuP-697 Alone and in Combination with Tyrosine Kinase Inhibitor (E7080) on Colon Cancer Cell Lines Colon cancer;DuP-697;COX-2 inhibition;tyrosine kinase inhibitor; Colorectal cancer remains one of the most common types of cancer and a leading cause of cancer death worldwide. In this study, we aimed to investigate effects of DuP-697, an irreversible selective inhibitor of COX-2 on colorectal cancer cells alone and in combination with a promising new multi-targeted kinase inhibitor E7080. The HT29 colorectal cancer cell line was used. Real time cell analysis (xCELLigence system) was conducted to determine effects on colorectal cell proliferation, angiogenesis was assessed with a chorioallantoic membrane model and apoptosis was determined with annexin V staining. We found that DuP-697 alone exerted antiproliferative, antiangiogenic and apoptotic effects on HT29 colorectal cancer cells. For the antiproliferative effect the half maximum inhibition concentration ($IC_{50
http://koreascience.or.kr/article/JAKO201418342937192.page?lang=en
Overexpression of ras in mucus-secreting human colon carcinoma cells of low tumorigenicity<...Overexpression of ras in mucus-secreting human colon carcinoma cells of low tumorigenicity<...
TY - JOUR. T1 - Overexpression of ras in mucus-secreting human colon carcinoma cells of low tumorigenicity. AU - Augenlicht, Leonard H.. AU - Augeron, C.. AU - Yander, G.. AU - Laboisse, C.. PY - 1987. Y1 - 1987. N2 - We have investigated the expression of the protooncogenes of the myc and ras family in HT29 cells and in three different clonal cell lines derived from this colon carcinoma cell line. In contrast to the decrease in myc expression seen when leukemia cells are induced to differentiate, we have found no changes in expression of the myc gene family in differentiated colon carcinoma cells. However, a greater than 5-fold increase in expression of sequences which hybridize to Ha-ras was observed in cells which secrete mucin, with a smaller increase seen in expression of Ki-ras in the same cells. This increase was not seen in cells which exhibit vectorial transport of water and ions, and which are not mucus-secreting. All differentiated lines were less tumorigenic in nude mice than the ...
https://einstein.pure.elsevier.com/en/publications/overexpression-of-ras-in-mucus-secreting-human-colon-carcinoma-ce-2
Colon and Rectal Cancer - Adjuvant Therapy | Beverly Hill ProctologistsColon and Rectal Cancer - Adjuvant Therapy | Beverly Hill Proctologists
With very few exceptions, initial therapy for colon cancer is adequate surgical resection. Subsequent surgical and pathologic staging will dictate the need for adjuvant therapy. Currently, Stage I colon cancer patients enjoy a high cure rate after surgery alone (,80%), and there is no evidence that these patients will benefit from any adjuvant therapy. Large randomized clinical trials have been more interested in Stage II and Stage III colon cancer patients whose cure rate can be as low as 30% after surgery alone. Early chemotherapy trials for colon cancer used the chemotherapeutic agents available at the time. Eventually, fluorinated pyrimidines (5-Fluorouracil or 5-FU) were shown to have activity against metastatic colorectal cancer. This finding led to several trials evaluating 5-FU as adjuvant therapy for high risk patients after surgery (Stage II and III colon cancer). In 1988, Buyse and colleagues(4) published a meta-analysis of all randomized controlled trials of adjuvant therapy with ...
https://lacolon.com/patient-education/adjuvant-therapy-for-colon-and-rectal-cancer
Both Transforming Growth Factor-β and Substrate Release Are Inducers of Apoptosis in a Human Colon Adenoma Cell Line<...
TY - JOUR. T1 - Both Transforming Growth Factor-β and Substrate Release Are Inducers of Apoptosis in a Human Colon Adenoma Cell Line. AU - Cheng Ya Wang, Ya Wang. AU - Eshleman, J. R.. AU - Willson, J. K V. AU - Markowitz, S.. PY - 1995/11/1. Y1 - 1995/11/1. N2 - VACO-330, a nontransfonned cell line established from a human colon adenoma, undergoes spontaneous apoptosis and shedding of cells into the culture medium. Shed cells were shown to be apoptotic, both by nuclear morphology and by generation of a typical laddered pattern of degraded DNA. Quantitation of DNA released into the medium, compared with the amount retained on the plate, demonstrated that 6.2 ± 1.1% of the total cell mass underwent apoptotic death daily. The addition of transforming growth factor β (20 ng/ml) accelerated this spontaneous apoptotic rate 3.2-fold. Moreover, apoptosis could be rapidly induced in up to 45% of the VACO-330 cells by using brief exposure to a calcium chelating medium to release the cells from the ...
https://utsouthwestern.pure.elsevier.com/en/publications/both-transforming-growth-factor-%CE%B2-and-substrate-release-are-induc
Survival of Women with Colon Cancer in Relation to Precancer Anthropometric Characteristics: the Iowa Womens Health Study |...Survival of Women with Colon Cancer in Relation to Precancer Anthropometric Characteristics: the Iowa Womens Health Study |...
This study showed that greater weight, waist, and WHR before diagnosis (at baseline) were risk factors for all-cause mortality for women diagnosed with colon cancer. These associations were independent of age at diagnosis, education, smoking, and stage. The HR of all-cause mortality was also increased among those in the obese BMI category and among those few women in the underweight BMI category compared with women of normal weight. This pattern is similar to the relationship between BMI and all-cause mortality among all IWHS women (7, 20).. There were also statistically significant positive associations of colon cancer mortality with waist circumference and WHR. Women in the highest tertiles of waist and WHR had a 30% to 40% greater colon cancer mortality (similar to all-cause mortality) compared with the lowest tertiles. However, BMI and weight were not significantly associated with colon cancer mortality. Thus, WHR, which reflects abdominal obesity, and waist circumference, which ...
https://cebp.aacrjournals.org/content/19/9/2229?ijkey=e9ca5d61976dbbb48ab36396f26dd363f525d6e0&keytype2=tf_ipsecsha
Is It Time to Talk to Your Adult Children About Colon Cancer? - Central Coast Endoscopy Centers
Youve probably talked to your kids about important issues like time management and personal finances, but have you ever talked to your kids about colon cancer? Contrary to what most people think, colon cancer is not just a disease for the elderly. In fact, young-onset colon cancer incidence is increasing in individuals under the age of 50. If youve never had the conversation with your kids about colon cancer prevention and awareness, now is the time.. Its very likely that you may not know how or when to bring up the subject, or even what to say. After all, colon cancer and colonoscopies are not exactly dinner table conversation. We couldnt agree more, so choose a setting that is comfortable for everyone. You could consider a family walk, a cup of coffee at the kitchen table, or a trip to your local park.. Once youve chosen the setting, you need to think of how you will present your message. Remember, your goal is to inform and encourage. It might help to begin with a few facts to inform ...
https://centralcoastendoscopycenters.com/news-article/is-it-time-to-talk-to-your-adult-children-about-colon-cancer-09132017
A metabolite of nobiletin, 4′-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by...A metabolite of nobiletin, 4′-demethylnobiletin and atorvastatin synergistically inhibits human colon cancer cell growth by...
Combining different chemopreventive agents is a promising strategy to reduce cancer incidence and mortality due to potential synergistic interactions between these agents. Previously, we demonstrated that oral administration of nobiletin (NBT, a citrus flavonoid) at 0.05% (w/w, in diet) together with atorvas
http://pubs.rsc.org/en/content/articlelanding/2017/fo/c7fo01155e
Reduced colon cancer incidence and mortality in postmenopausal women treated with an oral bisphosphonate--Danish National...
UNLABELLED: In this Danish national register-based cohort study, we examined the effects of alendronate on the development of colon cancers and survival. The incidence of colon cancer and mortality rate, once colon cancer had been diagnosed, were lower in patients treated with alendronate, posing the question whether alendronate acts as chemopreventive. INTRODUCTION: When bisphosphonates are given by mouth, around 99% remains non-absorbed in the intestine. Based on their biochemical actions, we predicted that oral bisphosphonates might prevent colon cancers. METHODS: This is a Danish national register-based cohort study. We identified 30,606 women aged 50+, mean age 71.9 years, who had not previously taken treatments for osteoporosis, who began to take alendronate in 1996-2005, and assigned 124,424 individually age- and gender-matched control subjects. The main outcome measure was colorectal cancers incidence and post-diagnosis survival in patients taking oral alendronate for osteoporosis. RESULTS: Cox
https://www.ndorms.ox.ac.uk/publications/360179
Compounds in Mate Tea Kill Colon Cancer Cells In Vitro | www.bioquicknews.comCompounds in Mate Tea Kill Colon Cancer Cells In Vitro | www.bioquicknews.com
Could preventing colon cancer be as simple as developing a taste for yerba mate tea? In a recent University of Illinois study, scientists showed that human colon cancer cells die when they are exposed to the approximate number of bioactive compounds present in one cup of this brew, which has long been consumed in South America for its medicinal properties. The caffeine derivatives in mate tea not only induced death in human colon cancer cells, they also reduced important markers of inflammation, said Dr. Elvira de Mejia, a University of Illinois associate professor of food chemistry and food toxicology. Thats important because inflammation can trigger the steps of cancer progression, she said. In the in vitro study, Dr. de Mejia and former graduate student Sirima Puangpraphant isolated, purified, and then treated human colon cancer cells with caffeoylquinic acid (CQA) derivatives from mate tea. As the scientists increased the CQA concentration, cancer cells died as a result of apoptosis. Put ...
http://www.bioquicknews.com/node/731
Cancers | Free Full-Text | Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon CancerCancers | Free Full-Text | Aberrant Crypt Foci: The Case for Inclusion as a Biomarker for Colon Cancer
Aberrant crypt foci (ACF) are one of the earliest histopathological manifestations of colon cancer. In this review, we critically present the molecular, cellular, histopathological, and chemopreventive evidence that ACF are relevant biomarkers for colon cancer. The laboratory and clinical evidence are highly suggestive that ACF are in the pathway leading to colon cancer, but not all ACF will do so. The possible fate and outcome of ACF in the progression toward colon cancer may be dependent on a number of features that define their predictive power for the prevention or progression of cancer.
http://www.mdpi.com/2072-6694/2/3/1705/xml
OPUS 4 | Prognostic value of MACC1 and proficient mismatch repair status for recurrence risk prediction in stage II colon...
Background We assessed the novel MACC1 gene to further stratify stage II colon cancer patients with proficient mismatch repair (pMMR). Patients and methods Four cohorts with 596 patients were analyzed: Charité 1 discovery cohort was assayed for MACC1 mRNA expression and MMR in cryo-preserved tumors. Charité 2 comparison cohort was used to translate MACC1 qRT-PCR analyses to FFPE samples. In the BIOGRID 1 training cohort MACC1 mRNA levels were related to MACC1 protein levels from immunohistochemistry in FFPE sections; also analyzed for MMR. Chemotherapy-naïve pMMR patients were stratified by MACC1 mRNA and protein expression to establish risk groups based on recurrence-free survival (RFS). Risk stratification from BIOGRID 1 was confirmed in the BIOGRID 2 validation cohort. Pooled BIOGRID datasets produced a best effect-size estimate. Results In BIOGRID 1, using qRT-PCR and immunohistochemistry for MACC1 detection, pMMR/MACC1-low patients had a lower recurrence probability versus pMMR/MACC1-high
https://opus4.kobv.de/opus4-zib/frontdoor/index/index/docId/6389
Spiral CT pneumocolon for suspected colonic neoplasms [1]<...Spiral CT pneumocolon for suspected colonic neoplasms [1]<...
TY - JOUR. T1 - Spiral CT pneumocolon for suspected colonic neoplasms [1]. AU - Coakley, F. V.. AU - Entwisle, J. J.. AU - Amin, Z.. AU - Lees, W. R.. PY - 1996. Y1 - 1996. UR - http://www.scopus.com/inward/record.url?scp=0029761122&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0029761122&partnerID=8YFLogxK. U2 - 10.1016/S0009-9260(96)80069-9. DO - 10.1016/S0009-9260(96)80069-9. M3 - Letter. C2 - 8810704. AN - SCOPUS:0029761122. VL - 51. SP - 666. JO - Clinical Radiology. JF - Clinical Radiology. SN - 0009-9260. IS - 9. ER - ...
https://ohsu.pure.elsevier.com/en/publications/spiral-ct-pneumocolon-for-suspected-colonic-neoplasms-1-2
Wnt Signaling in Colon Cancer Stem Cells - Nova Science PublishersWnt Signaling in Colon Cancer Stem Cells - Nova Science Publishers
Colorectal cancer is the second leading cause of cancer-related death in the United States. Among many gene mutations associated with colorectal cancer, mutation of APC (adenomatous polyposis coli) or ß-catenin, which activates Wnt signaling, represents the initiation step of colon tumorigenesis. Wnt signaling is known to play multiple roles in early development and formation of human cancers. In addition, Wnt signaling also regulates the self-renewal and differentiation of adult stem cells. Recently, cancer stem cells have emerged as an exciting new concept in cancer research. This book discusses the development and trends in the field of cancer stem cell research, with emphasis on colon cancer stem cells. (Imprint: Nova Biomedical). ...
https://novapublishers.com/shop/wnt-signaling-in-colon-cancer-stem-cells/
Plus itPlus it
CRC is the third most common cancer in men and women and is the third leading cause of cancer death (39, 40). Thus, the causes and methods of preventing and treating colon cancer are a high priority. In particular, abnormal activation of Wnt signaling has been tightly linked to colon cancer. Therefore, identifying small molecules targeting Wnt signaling is a promising preventive or treatment strategy against cancer.. In the current study, we identified a natural product, esculetin, as a potent inhibitor of Wnt signaling. Previously, the inhibitory effect of esculetin on cell proliferation in many cell lines has been reported (32, 33, 43, 44). However, the molecular mechanism of the antiproliferation effect of esculetin against colon cancer cells is not clearly understood. In the present study, we demonstrated that esculetin could disrupt the interaction between β-catenin and Tcf by targeting β-catenin, leading to suppression of the proliferation of three different colon cancer cell lines ...
http://cancerpreventionresearch.aacrjournals.org/content/6/12/1356
University Of Cincinnati Identifies Potential Colon Cancer Biomarker - NS Medical DevicesUniversity Of Cincinnati Identifies Potential Colon Cancer Biomarker - NS Medical Devices
Scientists have developed a novel biomarker that could help predict a persons risk of developing colon cancer at the University of Cincinnati. Hotspots has been identified which play a critical role in regulating gene expression and influence colon cancer progression. Researchers consider that these hotspots could be used as a biomarker for colon cancer. AMACR is the first study to explain how a gene is regulated in relation to cancer development and to identify specific genetic events (a polymorphism and somatic cell mutations) related to colon cancer. UC researchers looked at the actions of the AMACR gene in human tissue in this study. AMACR breaks down branched-chain fatty acids, a type of molecule only found in animals that eat plants. Previous research showed that plant-derived fatty acids, such as those found in red meat and dairy products, can accelerate cancer growth. AMACR genes abnormal expression patterns using a sophisticated laser-capture microdissection technique identifies the ...
https://www.nsmedicaldevices.com/news/university_of_cincinnati_identifies_potentialcancer_biomarker_090121/
Profiling the humoral immune response in colon cancer patients: Diagnostic antigens from Streptococcus bovis<...
TY - JOUR. T1 - Profiling the humoral immune response in colon cancer patients. T2 - Diagnostic antigens from Streptococcus bovis. AU - Tjalsma, Harold. AU - Schöller-Guinard, Marie. AU - Lasonder, Edwin. AU - Ruers, Theo J.. AU - Willems, Hans L.. AU - Swinkels, Dorine W.. PY - 2006/11/1. Y1 - 2006/11/1. N2 - The human bowel contains a large and dynamic bacterial population that is not only essential for intestinal health, but also critical for the development of diseases such as cancer. In this respect, the Gram-positive bacterium Streptococcus bovis has been associated with colon cancer for many years. To investigate the clinical importance of this association, an immunocapture mass spectrometry assay was developed that can generate infection-related protein profiles. The composition of these profiles is governed by the capture of specific antigens by serum antibodies from colon cancer patients. This assay showed that S. bovis antigen profiles could distinguish 11 out of 12 colon cancer ...
https://researchportal.northumbria.ac.uk/en/publications/profiling-the-humoral-immune-response-in-colon-cancer-patients-di
Estrogren Receptor Model, Illustration - Stock Image C027/6387 - Science Photo LibraryEstrogren Receptor Model, Illustration - Stock Image C027/6387 - Science Photo Library
A molecular ribbon model of estrogen receptor beta, a protein encoded by the ESR2 gene, found primarily in the kidneys, brain, bone, heart, lungs, intestinal mucosa, prostate and endothelial cells. After activated by estrogen hormones, estrogen receptors bind to DNA to regulate gene expression. Abnormal activity by estrogen receptors have been observed in cases of breast cancer, ovarian cancer, colon cancer, prostate cancer and endometrial cancer. The loss of estrogen receptor beta proteins can disrupt the process of apoptosis and are often associated with advanced colon cancer and the development of tumours. - Stock Image C027/6387
http://www.sciencephoto.com/media/703072/view
Atlas: SASH1 (SAM and SH3 domain containing 1)
The mRNA as well as protein expression of SASH1 was strongly and significantly reduced in colon cancer of UICC stage II, III, and IV, as well as in colorectal liver metastases. In contrast, SASH1 expression was not significantly altered in benign adenomas and in early stage lesions (UICC I). Around 40% of primary colon tumours tested (n=113) showed a 10-fold or stronger reduction in SASH1 expression, compared to normal colon mucosa. Decreased SASH1 mRNA expression was correlated with the occurrence of metachronous distant metastasis, and multivariate analysis identified SASH1 downregulation as an independent negative prognostic parameter for patient survival (Rimkus et al., 2006). Recently, these results were confirmed on an independent patient collective of stage II colon cancer (n=179 patients), confirming that decreased SASH1 expression is an independent negative prognostic factor in colon cancer, allowing to distinguish high-risk patients in early, locally restriced stages of the disease ...
https://atlasgeneticsoncology.usal.es/classic/Genes/GC_SASH1.html
cecum cancer stages
Researchers compile survival rates based on observed survival of a large number of people diagnosed with cecum cancer, notes the American Cancer … 0. as a child. See the Introduction for a list of those NETs. If the bowel cancer disease has breached the bowel wall, and especially if it is has gone into the local lymph nodes, adjuvant chemotherapy will increase the chance of cure. Despite this prognosis, right-sided colon cancers are less likely to spread (metastasize) to the liver and lungs than left-sided colon cancers.. Boston: Butterworths; 1990. Currently, doctors have not yet studied the cancer of the cecum to the end, therefore only approximate causes are known. TX: The primary tumor cannot be evaluated. Anatomically, the cecum sits in the right lower area of your abdomen, where your appendix is positioned. This region of the colon can be difficult to examine, but is important, in that some studies have found that up to 20% of colorectal cancers occur in the cecum (in some studies ...
http://equipement-hardware.com/good-mood-mxa/cecum-cancer-stages-b88d3e
A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis | Clinical Epigenetics | Full...A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis | Clinical Epigenetics | Full...
MicroRNAs (miRNAs or miRs) are short non-coding RNAs that affect the expression of genes involved in normal physiology, but that also become dysregulated in cancer development. In the latter context, studies to date have focused on high-abundance miRNAs and their targets. We hypothesized that among the pool of low-abundance miRNAs are some with the potential to impact crucial oncogenic signaling networks in colon cancer. Unbiased screening of over 650 miRNAs identified miR-206, a low-abundance miRNA, as the most significantly altered miRNA in carcinogen-induced rat colon tumors. Computational modeling highlighted the stem-cell marker Krüppel-like factor 4 (KLF4) as a potential target of miR-206. In a panel of primary human colon cancers, target validation at the mRNA and protein level confirmed a significant inverse relationship between miR-206 and KLF4, which was further supported by miR-206 knockdown and ectopic upregulation in human colon cancer cells. Forced expression of miR-206 resulted in
https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/1868-7083-4-16
Development and validation of a robust molecular diagnostic test (COLOPRINT) for predicting outcome in stage II colon cancer...Development and validation of a robust molecular diagnostic test (COLOPRINT) for predicting outcome in stage II colon cancer...
Background Only between 25 to 35% of stage II and IIIA colon cancer patients will experience a relapse of their disease and may benefit from adjuvant chemotherapy. ColoPrint is a gene expression classifier that can predict disease relapse in patients with early-stage colorectal cancer and helps to identify patients with higher risk of relapse.. Methods ColoPrint was developed using whole genome expression data and was validated in public datasets and an independent patient cohort of 206 patients (Salazar et al., JCO 2011). The signature was translated to a customized 8-pack microarray. Positive and negative hybridization control genes monitor the quality of hybridization and a colon specific normalization gene set (n = 461) guarantee reliability of results. Reproducibility and precision studies with 20 times 6 samples were performed by multiple operators on multiple days. Additional independent patient cohorts were validated on the customized arrays. Uni- and multi-variate analyses were ...
http://oncologypro.esmo.org/Topics/Gastrointestinal-Cancers/Rectal-Cancer/Development-and-validation-of-a-robust-molecular-diagnostic-test-COLOPRINT-for-predicting-outcome-in-stage-II-colon-cancer-patients
THE POTENTIAL DICHOTOMOUS ROLE OF ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3) IN COLON CANCERTHE POTENTIAL DICHOTOMOUS ROLE OF ACTIVATING TRANSCRIPTION FACTOR 3 (ATF3) IN COLON CANCER
Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States. During the tumorigenesis and metastasis of CRC, cells encounter numerous cellular and molecular events. ATF3, a member of the ATF/CREB transcription factor family, plays an important role on regulation of apoptosis and is regarded as a potential molecular target for chemoprevention and chemotherapy of colon cancer. The current study was performed to investigate cellular and molecular mechanisms by which ATF3 affects colon cancer-related phenotypes including apoptosis and metastasis. Here, we demonstrated that knockdown of ATF3 using small interfering RNA (siRNA) promotes the expression of anti-apoptotic protein, B-cell lymphoma 2 (Bcl-2), in colon cancer cells, while overexpression of ATF3 resulted in a dramatic decrease in Bcl-2 protein. Gain of function of ATF3 in colon cancer cell line HCT116 led to an increase of pro-apoptotic protein Bcl-2 homologous antagonist killer (Bak), followed by the ...
https://drum.lib.umd.edu/handle/1903/17382
Comparative study of human colonic tumor-derived endothelial cells (HCTEC) and normal colonic microvascular endothelial cells ...Comparative study of human colonic tumor-derived endothelial cells (HCTEC) and normal colonic microvascular endothelial cells ...
Colorectal carcinoma growth and progression is dependent on the vasculature of the tumor microenvironment. Tumor-derived endothelial cells differ functionally from their normal counterpart. For this reason we isolated microvascular endothelial cells from human colon cancer tissue (HCTEC) and compared them with endothelial cells from normal colonic tissue (HCMEC) of the same donor. Since hypoxia is a universal hallmark of carcinomas, we examined its effects on HCTEC of five patients in comparison with the corresponding HCMEC, with respect to the secretion of the soluble form of the two important vascular endothelial growth factor (VEGF) receptors, VEGFR-1 and -2. After dissociation by dispase/collagenase of central non-necrotic tumor areas obtained from colon carcinomas, HCTEC were isolated using CD31-coated magnetic beads and cultivated as monolayers. Subsequent characterization studies demonstrated the endothelial phenotype, including VEGFR-1 and -2 mRNA and protein expression as well as E-selectin
https://www.semanticscholar.org/paper/Comparative-study-of-human-colonic-tumor-derived-e-Jayasinghe-Simiantonaki/eb1d988e5f4b168f301fd4d40637d6014302cd15
JCI - cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicityJCI - cGAS/STING axis mediates a topoisomerase II inhibitor-induced tumor immunogenicity
Mice and reagents. Six- to eight-week-old female C57BL/6J and BALB/c mice were purchased from the Charles River Laboratory. OT-I mice and Ifnar-/- mice were obtained from Jackson Laboratory. All the mice were maintained under specific pathogen-free conditions.. The B16 (C57BL/6 mouse melanoma), LSV174T (human colon adenocarcinoma), CT26 (BALB/c mouse colon adenocarcinoma), and HEK293 cell lines were obtained from ATCC. MC38 (C57BL/6 mouse colon adenocarcinoma) was provided by Yang Xuanming (Shanghai Jiaotong University, Shanghai, China). B16-OVA cells were constructed by stably expressing OVA cDNA on B16 cells. PDAC murine pancreatic cancer cells were derived from spontaneous pancreatic cancer tissues of K-ras(G12D); p53-/- mice (51). DC2.4, a murine DC line, was provided by Kenneth Dock (University of Massachusetts Medical School, Worcester, Massachusetts, USA). B3Z hybridoma cells were provided by Nilabh Shastri (University of California, Berkeley, Berkeley, California, USA). All cell lines ...
https://jci.org/articles/view/127471
ColoLipidGene: Signature of lipid metabolism-related genes to predict prognosis in stage-II colon cancer patients
Lipid metabolism plays an essential role in carcinogenesis due to the requirements of tumoral cells to sustain increased structural, energetic and biosynthetic precursor demands for cell proliferation. We investigated the association between expression of lipid metabolism-related genes and clinical outcome in intermediate-stage colon cancer patients with the aim of identifying a metabolic profile associated with greater malignancy and increased risk of relapse. Expression profile of 70 lipid metabolismrelated genes was determined in 77 patients with stage II colon cancer. Cox regression analyses using c-index methodology was applied to identify a metabolic-related signature associated to prognosis. The metabolic signature was further confirmed in two independent validation sets of 120 patients and additionally, in a group of 264 patients from a public database. The combined analysis of these 4 genes, ABCA1, ACSL1, AGPAT1 and SCD, constitutes a metabolic-signature (ColoLipidGene) able to ...
http://repositorio.uam.es/handle/10486/671590
Thymidine kinase in clinical chemistryThymidine kinase in clinical chemistry
Lipkin M, Deschner E, Troncale F (1970). "Cell differentiation and the development of colonic neoplasms". CA: A Cancer Journal ... "Biochemical measure of the volume doubling time of human pulmonary neoplasms". Cancer. 55 (7): 1530-5. doi:10.1002/1097-0142( ...
https://en.wikipedia.org/wiki/Thymidine_kinase_in_clinical_chemistry
SupertasterSupertaster
Bitterness and Colonic Neoplasms". Digestive Diseases and Sciences. 50 (3): 483-9. doi:10.1007/s10620-005-2462-7. PMID 15810630 ...
https://en.wikipedia.org/wiki/Supertaster
FolliculinFolliculin
April 2002). "Risk of renal and colonic neoplasms and spontaneous pneumothorax in the Birt-Hogg-Dubé syndrome". Cancer ... cosegregation of kidney neoplasms with BHD cutaneous lesions was observed in 3 families with a family history of kidney tumors ...
https://en.wikipedia.org/wiki/Folliculin
ChromoendoscopyChromoendoscopy
... violet is absorbed into intestinal and neoplastic cells and is used to identify Barrett's esophagus and colonic neoplasms.[ ... characterization of colonic polyps and colorectal cancer, and in screening for dysplasia in individuals with ulcerative colitis ...
https://en.wikipedia.org/wiki/Chromoendoscopy
List of MeSH codes (C04)List of MeSH codes (C04)
... colonic neoplasms MeSH C04.588.274.476.411.307.180.089 - adenomatous polyposis coli MeSH C04.588.274.476.411.307.180.089.500 - ... skull base neoplasms MeSH C04.588.149.828 - spinal neoplasms MeSH C04.588.180.260 - breast neoplasms, male MeSH C04.588.180.390 ... bile duct neoplasms MeSH C04.588.274.120.250.250 - common bile duct neoplasms MeSH C04.588.274.120.401 - gallbladder neoplasms ... femoral neoplasms MeSH C04.588.149.721 - skull neoplasms MeSH C04.588.149.721.450 - jaw neoplasms MeSH C04.588.149.721.450.583 ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C04)
List of MeSH codes (C06)List of MeSH codes (C06)
... appendiceal neoplasms MeSH C06.301.371.411.307 - colorectal neoplasms MeSH C06.301.371.411.307.180 - colonic neoplasms MeSH ... appendiceal neoplasms MeSH C06.405.249.411.307 - colorectal neoplasms MeSH C06.405.249.411.307.180 - colonic neoplasms MeSH ... appendiceal neoplasms MeSH C06.405.469.491.307 - colorectal neoplasms MeSH C06.405.469.491.307.180 - colonic neoplasms MeSH ... cecal neoplasms MeSH C06.405.469.110.417.290 - appendiceal neoplasms MeSH C06.405.469.158 - colonic diseases MeSH C06.405. ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C06)
DNA glycosylaseDNA glycosylase
... compared to histologically normal tissue from individuals who never had a colonic neoplasm. This finding suggests that ... MBD4 expression is reduced in almost all colorectal neoplasms due to methylation of the promoter region of MBD4. Also MBD4 is ...
https://en.wikipedia.org/wiki/DNA_glycosylase
MBD4MBD4
... compared to histologically normal tissue from individuals who never had a colonic neoplasm. This indicates that an epigenetic ... MBD4 mRNA expression is reduced in colorectal neoplasms due to methylation of the promoter region of MBD4. A majority of ...
https://en.wikipedia.org/wiki/MBD4
Base excision repairBase excision repair
... compared to histologically normal tissue from individuals who never had a colonic neoplasm. This finding suggests that ... MBD4 expression is reduced in almost all colorectal neoplasms due to methylation of the promoter region of MBD4. Also MBD4 is ...
https://en.wikipedia.org/wiki/Base_excision_repair
Thyroid neoplasmThyroid neoplasm
Colonic adenocarcinoma metastatic to the thyroid gland (e); the thyroid tissue is positive for thyroglobulin while the ... Thyroid neoplasm is a neoplasm or tumor of the thyroid. It can be a benign tumor such as thyroid adenoma, or it can be a ... Thyroid neoplasm might be classified as benign or malignant.[citation needed] Thyroid adenoma is a benign neoplasm of the ... The first step in diagnosing a thyroid neoplasm is a physical exam of the neck area. If any abnormalities exist, a doctor needs ...
https://en.wikipedia.org/wiki/Thyroid_neoplasm
NeoplasmNeoplasm
indicated that macrophages and neutrophils in an inflamed colonic epithelium are the source of reactive oxygen species causing ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The term neoplasm is a synonym of tumor. Neoplasia denotes the process of the formation of neoplasms/tumors, and the process is ... The process that occurs to form or produce a neoplasm is called neoplasia. The growth of a neoplasm is uncoordinated with that ...
https://en.wikipedia.org/wiki/Neoplasm
Bowel obstructionBowel obstruction
Neoplasms / cancer Diverticulitis / Diverticulosis Hernias Inflammatory bowel disease Colonic volvulus (sigmoid, caecal, ... sutures Pseudoobstruction Hernias containing bowel Crohn's disease causing adhesions or inflammatory strictures Neoplasms, ...
https://en.wikipedia.org/wiki/Bowel_obstruction
EndoscopeEndoscope
Large intestine: nonspecific ulcerative colitis, Crohn's disease, chronic colitis, colonic polyps, colorectal cancer, etc. The ... Small intestine: small intestine neoplasms, smooth muscle tumors, sarcomas, polyps, lymphomas, inflammation, etc. ...
https://en.wikipedia.org/wiki/Endoscope
Lower gastrointestinal bleedingLower gastrointestinal bleeding
The presence of fresh blood in the terminal ileum is presumed to indicate a non colonic source of bleeding. The overall ... H7 Shigella Salmonella Campylobacter jejuni Hemorrhoids Neoplasm - such as colorectal cancer Angiodysplasia Bleeding from a ... use is a risk factor for diverticular bleeding and NSAID-induced colonic ulcer; and recent colonoscopy with polypectomy ... site where a colonic polyp was removed Inflammatory bowel disease such as Crohn's disease or ulcerative colitis Rectal varices ...
https://en.wikipedia.org/wiki/Lower_gastrointestinal_bleeding
Colorectal polypColorectal polyp
A neoplasm is a tissue whose cells have lost normal differentiation. They can be either benign growths or malignant growths. ... Micrograph of a Peutz-Jeghers colonic polyp - a type of hamartomatous polyp. H&E stain. Micrograph of a tubular adenoma - ... Saunders B, Ginsberg GG, Bjorkman DJ (2008). "How I do it: Removing large or sessile colonic polyps" (PDF). Munich: OMED. ... Paris classification of colorectal neoplasms. In colonoscopy, colorectal polyps can be classified by NICE (Narrow-band imaging ...
https://en.wikipedia.org/wiki/Colorectal_polyp
MIRN21MIRN21
"Faecal microRNAs as a non-invasive tool in the diagnosis of colonic adenomas and colorectal cancer: A meta-analysis". ... it has been demonstrated as an independent prognostic factor in patients with pancreatic neuroendocrine neoplasms. miR-21 has ... "Prognostic relevance of proliferation-related miRNAs in pancreatic neuroendocrine neoplasms". European Journal of Endocrinology ...
https://en.wikipedia.org/wiki/MIRN21
Ovarian mucinous tumorOvarian mucinous tumor
It is well documented that malignancy may be only focally present in mucinous neoplasms of the ovary, so thorough sampling is ... The appearance can look similar to colonic cancer. Clear stromal invasion is used to differentiate borderline tumors from ... Mucinous tumors are part of the surface epithelial-stromal tumor group of ovarian neoplasms, and account for approximately 36% ...
https://en.wikipedia.org/wiki/Ovarian_mucinous_tumor
PilomatricomaPilomatricoma
These neoplasms are relatively uncommon and typically occur on the scalp, face, and upper extremities. Clinically, ... This association has prognostic import, since cutaneous findings in children with Gardner Syndrome generally precede colonic ... Malignant pilomatricoma List of cutaneous conditions List of cutaneous neoplasms associated with systemic syndromes Rapini, ...
https://en.wikipedia.org/wiki/Pilomatricoma
Guanylate cyclase 2CGuanylate cyclase 2C
2009). "Guanylyl cyclase C is a specific marker for differentiating primary and metastatic ovarian mucinous neoplasms". ... the colonic cell line". Biochim. Biophys. Acta. 1498 (1): 32-43. doi:10.1016/s0167-4889(00)00075-6. PMID 11042348. Ciocca V, ...
https://en.wikipedia.org/wiki/Guanylate_cyclase_2C
Intestinal pseudo-obstructionIntestinal pseudo-obstruction
Gastric and colonic pacemakers have been tried. These are strips placed along the colon or stomach which create an electric ... Bowel obstruction: mechanical or functional obstruction of the bowel, most commonly due to adhesions, hernias or neoplasms. ... Briejer MR, Prins NH, Schuurkes JA (October 2001). "Effects of the enterokinetic prucalopride (R093877) on colonic motility in ... Saunders MD (October 2004). "Acute colonic pseudoobstruction". Current Gastroenterology Reports. 6 (5): 410-6. doi:10.1007/ ...
https://en.wikipedia.org/wiki/Intestinal_pseudo-obstruction
MORT (long non-coding RNA)MORT (long non-coding RNA)
... and colonic adenomas, a premalignant lesion of colon adenocarcinoma. Furthermore epigenetic silencing of MORT is associated ... lymphoid neoplasm diffuse large B-cell lymphoma, pancreatic adenocarcinoma, rectum adenocarcinoma, skin cutaneous melanoma, and ...
https://en.wikipedia.org/wiki/MORT_(long_non-coding_RNA)
Gardners syndromeGardner's syndrome
Gardner syndrome is set apart as a subtype because, in addition to colonic polyps, there are also extra-colonic growths (both ... The incidence of mammary desmoid tumors is less than 0.2% of primary breast neoplasms. In Gardner's syndrome, the incidence ... Baranov E, Hornick JL (March 2020). "Soft Tissue Special Issue: Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck ... List of cutaneous conditions List of dental abnormalities associated with cutaneous conditions List of cutaneous neoplasms ...
https://en.wikipedia.org/wiki/Gardner's_syndrome
Surface epithelial-stromal tumorSurface epithelial-stromal tumor
... s are a class of ovarian neoplasms that may be benign or malignant. Neoplasms in this group are ... The appearance can look similar to colonic or ovarian cancer, but typically originates from the appendix (see mucinous ... One rare but noteworthy condition associated with mucinous ovarian neoplasms is pseudomyxoma peritonei. As primary ovarian ... of all ovarian neoplasms In some cases mucinous tumors are characterized by more cysts of variable size and a rarity of surface ...
https://en.wikipedia.org/wiki/Surface_epithelial-stromal_tumor
Mouse model of colorectal and intestinal cancerMouse model of colorectal and intestinal cancer
In the colonic tissues of mice fed diet plus DOC similar changes in biomarkers occurred. Thus, 8-OH-dG was increased, DNA ... 1996). "Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice". Cancer Res. 56 (16): 3842-9. PMID 8706033 ... 1998). "Development of colonic adenocarcinomas in a mouse model of ulcerative colitis". Inflamm. Bowel Dis. 4 (3): 196-202. doi ... After 8-10 months, 45% to 56% of the mice developed colonic adenocarcinomas, and no mice had cancers of the small intestine. On ...
https://en.wikipedia.org/wiki/Mouse_model_of_colorectal_and_intestinal_cancer
EosinophiliaEosinophilia
Of solid tumor neoplasms, ovarian cancer is most likely to provoke eosinophilia, though any other cancer can cause the ... Beeken WL, Northwood I, Beliveau C, Baigent G, Gump D (1987). "Eosinophils of human colonic mucosa: C3b and Fc gamma receptor ... The World Health Organization classifies these disorders into a) Myeloid and lymphoid neoplasms with eosinophilia and ... Reiter A, Gotlib J (2017). "Myeloid neoplasms with eosinophilia". Blood. 129 (6): 704-714. doi:10.1182/blood-2016-10-695973. ...
https://en.wikipedia.org/wiki/Eosinophilia
Anaerobic infectionAnaerobic infection
Some solid malignant tumors, ( colonic, uterine and bronchogenic, and head and neck necrotic tumors, are more likely to become ... malignant neoplasms intestinal obstruction; decubitus ulcers; dental extraction; sickle cell disease; diabetes mellitus; ... often to yield colonic flora organisms. These are generally B. fragilis group, Clostridium spp., Enterobacteriaceae and ...
https://en.wikipedia.org/wiki/Anaerobic_infection
Chronic lymphocytic leukemiaChronic lymphocytic leukemia
Hairy cell leukemia is also a neoplasm of B lymphocytes, but the neoplastic cells have a distinct morphology under the ... Colonic perforation secondary to chronic lymphocytic leukemia infiltration without Richter transformation. Leuk Lymphoma. 2011 ... ISBN 978-0-7817-5007-3. Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and ... Choi SM, O'Malley DP (December 2018). "Diagnostically relevant updates to the 2017 WHO classification of lymphoid neoplasms". ...
https://en.wikipedia.org/wiki/Chronic_lymphocytic_leukemia
Pulmonary enteric adenocarcinomaPulmonary enteric adenocarcinoma
CT and colonoscopy to rule out a colonic primary are recommended.[citation needed] Optimal treatment for this condition is not ... Neoplasm stubs). ...
https://en.wikipedia.org/wiki/Pulmonary_enteric_adenocarcinoma
Clonally transmissible cancerClonally transmissible cancer
In 1986, a laboratory worker accidentally bruised herself with the needles she was using to inject colonic cancer cells into ... Frierman EM, Andrews JD (February 1976). "Occurrence of hematopoietic neoplasms in Virginia oysters (Crassostrea virginica)". ... Gugel EA, Sanders ME (December 1986). "Needle-stick transmission of human colonic adenocarcinoma". The New England Journal of ... have been found to be vulnerable to a transmissible neoplasm of the hemolymphatic system - effectively, leukemia. The cells ...
https://en.wikipedia.org/wiki/Clonally_transmissible_cancer
MastocytosisMastocytosis
"Performing Colonic Mast Cell Counts in Patients With Chronic Diarrhea of Unknown Etiology Has Limited Diagnostic Use". Archives ... "The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): ... Systemic mastocytosis with associated hematological neoplasm (SM-AHN) Aggressive systemic mastocytosis (ASM) Mast cell leukemia ...
https://en.wikipedia.org/wiki/Mastocytosis
List of diseases (C)List of diseases (C)
... familial nonpolyposis Colonic atresia Colonic malakoplakia Color blindness Colorado tick fever Colver-Steer-Godman syndrome ... Carrington syndrome Cartilage hair hypoplasia like syndrome Cartilage-hair hypoplasia Cartilaginous neoplasms Cartwright-Nelson ... hypoxia Cerebral malformations hypertrichosis claw hands Cerebral palsy Cerebral thrombosis Cerebral ventricle neoplasms ... Choriocarcinoma Chorioretinitis Chorioretinopathy dominant form microcephaly Choroid plexus cyst Choroid plexus neoplasms ...
https://en.wikipedia.org/wiki/List_of_diseases_(C)
Stem cell markerStem cell marker
Misago N, Narisawa Y (September 2006). "Cytokeratin 15 expression in neoplasms with sebaceous differentiation". Journal of ... isografts from normal and transgenic mice to study the programming of positional information along the duodenal-to-colonic axis ...
https://en.wikipedia.org/wiki/Stem_cell_marker
List of MeSH codes (C23)List of MeSH codes (C23)
... neoplasm seeding MeSH C23.550.727.650.895 - neoplasms, unknown primary MeSH C23.550.727.655 - neoplasm recurrence, local MeSH ... colonic polyps MeSH C23.300.825.557 - nasal polyps MeSH C23.300.970.500 - intestinal volvulus MeSH C23.550.073.093 - arrhythmia ... neoplasm metastasis MeSH C23.550.727.650.560 - lymphatic metastasis MeSH C23.550.727.650.645 - neoplasm circulating cells MeSH ... C23.550.727.670 - neoplasm regression, spontaneous MeSH C23.550.727.700 - neoplasm, residual MeSH C23.550.737.500 - retrograde ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(C23)
Large intestineLarge intestine
As estimated from the image in panel A, there are about 100 colonic crypts per square millimeter of the colonic epithelium. ... and left-sided colorectal neoplasms after colonoscopy: population-based study". J Natl Cancer Inst. 102 (2): 89-95. doi:10.1093 ... Colonic crypts deficient for CCOI in women reaches, on average, 18% in women and 23% in men by 80-84 years of age. Crypts of ... measuring the number of cells in a small number of crypts reported a range of 1,500 to 4,900 cells per colonic crypt. Cells are ...
https://en.wikipedia.org/wiki/Large_intestine
ColonoscopyColonoscopy
Colonic polypectomy has become a routine part of colonoscopy, allowing quick and simple removal of polyps during the procedure ... and left-sided colorectal neoplasms after colonoscopy: population-based study". J Natl Cancer Inst. 102 (2): 89-95. doi:10.1093 ... Detailed examination of duodenal walls and folds, colonic walls and haustra was performed using a 7.5 MHz probe. Deeply located ... Wolff WI, Shinya H (September 1974). "Earlier diagnosis of cancer of the colon through colonic endoscopy (colonoscopy)". Cancer ...
https://en.wikipedia.org/wiki/Colonoscopy
Epstein-Barr virus-associated lymphoproliferative diseasesEpstein-Barr virus-associated lymphoproliferative diseases
Dalia S, Shao H, Sagatys E, Cualing H, Sokol L (October 2014). "Dendritic cell and histiocytic neoplasms: biology, diagnosis, ... of Epstein-Barr Virus Negative Inflammatory Pseudotumor-like Follicular Dendritic Cell Sarcoma Presenting as a Solitary Colonic ... Tang VK, Vijhani P, Cherian SV, Ambelil M, Estrada-Y-Martin RM (2018). "Primary pulmonary lymphoproliferative neoplasms". Lung ... An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation". The ...
https://en.wikipedia.org/wiki/Epstein–Barr_virus–associated_lymphoproliferative_diseases
Familial adenomatous polyposisFamilial adenomatous polyposis
... the resulting colonic polyps and cancers are initially confined to the colon wall. Detection and removal before metastasis ... Fibroblastic and Myofibroblastic Neoplasms of the Head and Neck". Head and Neck Pathology. 14 (1): 43-58. doi:10.1007/s12105- ...
https://en.wikipedia.org/wiki/Familial_adenomatous_polyposis
Somatic evolution in cancerSomatic evolution in cancer
... which may be benign neoplasms) or else a malignant neoplasm (cancer). These neoplasms are also indicated, in the diagram below ... In contrast, in colon tumors compared to adjacent normal-appearing colonic mucosa, there are about 600 to 800 somatically ... Neoplasms are mosaics of different mutant cells with both genetic and epigenetic changes that distinguish them from normal ... In this way, a population of mutant cells, called a clone, can expand in the neoplasm. Clonal expansion is the signature of ...
https://en.wikipedia.org/wiki/Somatic_evolution_in_cancer
Regulation of transcription in cancerRegulation of transcription in cancer
In contrast, in colon tumors compared to adjacent normal-appearing colonic mucosa, there are about 600 to 800 heavily ... Such mutations and epigenetic alterations can give rise to cancer (see malignant neoplasms). Thus, CpG island hyper/hypo- ...
https://en.wikipedia.org/wiki/Regulation_of_transcription_in_cancer
Birt-Hogg-Dubé syndromeBirt-Hogg-Dubé syndrome
People with BHD were once thought to be at higher risk for colorectal polyps and neoplasms, but this has been disproven. The ... These include multinodular goiter, medullary thyroid carcinoma, parotid oncocytoma, colonic polyposis, connective tissue nevus ... neoplasms, and cysts, Autosomal dominant disorders, Syndromes with tumors, Syndromes affecting the lung, Rare syndromes). ...
https://en.wikipedia.org/wiki/Birt–Hogg–Dubé_syndrome
CarcinogenesisCarcinogenesis
Mutant cells in neoplasms compete for space and resources. Thus, a clone with a mutation in a tumor suppressor gene or oncogene ... Macrophages and neutrophils in an inflamed colonic epithelium are the source of reactive oxygen species causing the DNA damage ... Some of the small polyps in the field defect shown in the photo of the opened colon segment may be relatively benign neoplasms ... November 2010). "Methylation tolerance due to an O6-methylguanine DNA methyltransferase (MGMT) field defect in the colonic ...
https://en.wikipedia.org/wiki/Carcinogenesis
Browsing by Subject Colonic NeoplasmsBrowsing by Subject "Colonic Neoplasms"
JavaScript is disabled for your browser. Some features of this site may not work without it ...
https://extranet.who.int/iris/restricted/browse?authority=Colonic+Neoplasms&type=mesh
Results of search for 'su:{Colonic neoplasms.}' › WHO HQ Library catalog
Neoplasms of the colon, rectum, and anus : mucosal and epithelial / [edited by] John S. Spratt ; Norma Braver, editorial ...
https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7BColonic%20neoplasms.%7D
Biblio | Page 30 | Linus Pauling Institute | Oregon State UniversityBiblio | Page 30 | Linus Pauling Institute | Oregon State University
Colonic Neoplasms. Blum CA, Tanaka T, Zhong X, Li Q, Dashwood W-M, Pereira C, Xu M, Dashwood RH. 2003. Mutational analysis of ... Liver Neoplasms. Blum CA, Tanaka T, Zhong X, Li Q, Dashwood W-M, Pereira C, Xu M, Dashwood RH. 2003. Mutational analysis of ... Skin Neoplasms. Blum CA, Tanaka T, Zhong X, Li Q, Dashwood W-M, Pereira C, Xu M, Dashwood RH. 2003. Mutational analysis of ... Intestinal Neoplasms. Blum CA, Tanaka T, Zhong X, Li Q, Dashwood W-M, Pereira C, Xu M, Dashwood RH. 2003. Mutational analysis ...
https://lpi.oregonstate.edu/biblio?f%5Bauthor%5D=6216&o=asc&page=29&s=keyword
Colorectal Cancer | Colon Cancer | Rectal Cancer | MedlinePlusColorectal Cancer | Colon Cancer | Rectal Cancer | MedlinePlus
ClinicalTrials.gov: Colonic Neoplasms (National Institutes of Health) * ClinicalTrials.gov: Colorectal Neoplasms (National ...
https://medlineplus.gov/colorectalcancer.html
Chromoendoscopy Technique: Approach Considerations, Use of Staining Agents in EndoscopyChromoendoscopy Technique: Approach Considerations, Use of Staining Agents in Endoscopy
Cohen-Mekelburg S, Schneider Y, Gold S, Scherl E, Steinlauf A. Advances in the Diagnosis and Management of Colonic Dysplasia in ... between I-SCAN-Optical Enhancement and Chromoendoscopy for Evaluating the Horizontal Margins of Gastric Epithelial Neoplasms. ... Chromoendoscopy versus narrow band imaging for colonic surveillance in inflammatory bowel disease. Inflamm Bowel Dis. 2013 Sep ... Interobserver and intra-observer consistency in the endoscopic assessment of colonic pit patterns. Gastrointest Endosc. 2004 ...
https://emedicine.medscape.com/article/1891483-technique
Browsing by SubjectBrowsing by Subject
Colonic Neoplasms [‎1]‎. Colony Count, Microbial [‎1]‎. Color [‎1]‎. Color Perception Tests [‎1]‎. ...
https://apps.who.int/iris/browse?rpp=20&offset=1146&etal=-1&sort_by=-1&type=mesh&starts_with_previous=D&order=ASC
Recent developments in nonspecific inflammatory bowel disease (first of two parts)Recent developments in 'nonspecific' inflammatory bowel disease (first of two parts)
Colonic Neoplasms / etiology * Colonic Neoplasms / pathology * Crohn Disease* / complications * Crohn Disease* / diagnosis ...
https://pubmed.ncbi.nlm.nih.gov/7038488/?dopt=Abstract
Laparoscopic-Assisted Surgery Compared With Open Surgery in Treating Patients With Colon Cancer - Full Text View -...Laparoscopic-Assisted Surgery Compared With Open Surgery in Treating Patients With Colon Cancer - Full Text View -...
Colonic Neoplasms. Colorectal Neoplasms. Intestinal Neoplasms. Gastrointestinal Neoplasms. Digestive System Neoplasms. ... Neoplasms by Site. Neoplasms. Digestive System Diseases. Gastrointestinal Diseases. Colonic Diseases. Intestinal Diseases. ...
https://clinicaltrials.gov/show/NCT00002575
An epitope localized in c-SRC negative regulatory domain is a potential marker in early stage of colonic neoplasms<...An epitope localized in c-SRC negative regulatory domain is a potential marker in early stage of colonic neoplasms<...
An epitope localized in c-SRC negative regulatory domain is a potential marker in early stage of colonic neoplasms. In: ... An epitope localized in c-SRC negative regulatory domain is a potential marker in early stage of colonic neoplasms. Laboratory ... An epitope localized in c-SRC negative regulatory domain is a potential marker in early stage of colonic neoplasms. / Sakai, ... title = "An epitope localized in c-SRC negative regulatory domain is a potential marker in early stage of colonic neoplasms", ...
https://pure.fujita-hu.ac.jp/en/publications/an-epitope-localized-in-c-src-negative-regulatory-domain-is-a-pot
NIOSHTIC-2 Search Results - Full View
Biblio | Linus Pauling Institute | Oregon State UniversityBiblio | Linus Pauling Institute | Oregon State University
Colonic Neoplasms. Wang R, Dashwood W-M, Nian H, Löhr CV, Fischer KA, Tsuchiya N, Nakagama H, Ashktorab H, Dashwood RH. 2011. ...
https://lpi.oregonstate.edu/biblio?f%5Bauthor%5D=5541&o=asc&s=keyword
Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)
Categories: Colonic Neoplasms Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 4 ...
https://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Colonic+Neoplasms&parentid=27779&catid=6756
NIOSHTIC-2 Search Results - Full View
Birt-Hogg-Dube Syndrome (BHDS) Treatment & Management: Medical Care, Surgical Care, ConsultationsBirt-Hogg-Dube Syndrome (BHDS) Treatment & Management: Medical Care, Surgical Care, Consultations
Risk of renal and colonic neoplasms and spontaneous pneumothorax in the Birt-Hogg-Dubé syndrome. Cancer Epidemiol Biomarkers ... Nagashima Y, Furuya M, Gotohda H, Takagi S, Hes O, Michal M. FLCN gene-mutated renal cell neoplasms: mother and daughter cases ... The principle concern of Birt-Hogg-Dubé syndrome is comorbid internal neoplasms. Associated conditions most commonly include ...
https://www.medscape.com/answers/1060579-164625/how-is-birt-hogg-dube-syndrome-treated
Medical Microbiology<...Medical Microbiology<...
Urinary Bladder Neoplasms 58% * Intravesical 57% * Colonic Neoplasms 55% 15 Citations (SciVal) ...
https://portal.research.lu.se/en/organisations/medical-microbiology
Bente Mertz Nørgård - Research output - University of Southern DenmarkBente Mertz Nørgård - Research output - University of Southern Denmark
Colonic Neoplasms 89% * Mental Disorders 80% * Cohort Studies 67% * Neoplasms 31% 132 Downloads (Pure) ...
https://portal.findresearcher.sdu.dk/en/persons/bente-n%C3%B8rg%C3%A5rd/publications/
Jennifer Chois Research | CureHunterJennifer Choi's Research | CureHunter
Colonic Neoplasms (Colon Cancer) 10/2015. 1. Ulcerative Colitis 10/2015. 1. Inflammation 10/2015. ...
https://www.curehunter.com/public/authorSummary-Choi,%20Jennifer.do
Gastroenterology and Hepatology - Research output - Mayo Clinic
Netters Gastroenterology Elsevier eBook on VitalSource, 3rd Edition - 9780323596275Netter's Gastroenterology Elsevier eBook on VitalSource, 3rd Edition - 9780323596275
Neoplasms of the Large Bowel: Colonic Polyps and Colon Cancer. *Familial Adenomatous Polyposis and Polyposis Syndromes ...
https://evolve.elsevier.com/cs/product/9780323596275?role=student
Issue 64: Ulcerative Colitis Cure - Vitamin E Enema & Diet at Vitamin E Enema & Diet For UC, topic 67345Issue 64: Ulcerative Colitis Cure - Vitamin E Enema & Diet at Vitamin E Enema & Diet For UC, topic 67345
Pharmacologic prevention of colonic neoplasms. Effects of calcium, vitamins, omega fatty acids, and nonsteroidal anti- ... While in rats given only a high haemin diet, free radical production and abnormal colonic cell growth escalated, in those who ... In this study, rats that already had abnormal colonic cell growths (called aberrant crypt foci) were injected with a ... Lieberman D, Prindiville S, Weiss D, Willett W. Risk factors for advanced colonic neoplasia and hyperplastic polyps in ...
https://www.curezone.org/forums/am.asp?i=67345
Stephen M Hewitt - Google ScholarStephen M Hewitt - Google Scholar
Risk of renal and colonic neoplasms and spontaneous pneumothorax in the Birt-Hogg-Dube syndrome. B Zbar, WG Alvord, G Glenn, M ...
https://scholar.google.de/citations?user=MOgUXuAAAAAJ&hl=de&oe=ASCII
HuGE Navigator|Genopedia|PHGKBHuGE Navigator|Genopedia|PHGKB
Colorectal Neoplasms 2 0 Breast Neoplasms 2 0 Colonic Neoplasms 1 0 ... Stomach Neoplasms 1 0 Note: The number of publications displayed in this table will differ from the number displayed in the ...
https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=MACC1&geneID=346389&typeSubmit=GO&check=y&typeOption=gene&which=2&pubOrderType=pubD
Random diets. - Nuffield Department of Population Health
Cellulose, Colonic Neoplasms, Dietary Fiber, Humans. © 2022 Nuffield Department of Population Health ...
https://www.ndph.ox.ac.uk/publications/79931?a1b96aec-737c-11ed-a564-061ab7f93640
Retention of in vivo antipyrimidine effects of brequinar sodium (DUP-785; NSC 368390) in murine liver, bone marrow and colon...
Colonic Neoplasms Medicine & Life Sciences 48% * Colon Medicine & Life Sciences 43% * Bone Marrow Medicine & Life Sciences 39% ...
https://jhu.pure.elsevier.com/en/publications/retention-of-in-vivo-antipyrimidine-effects-of-brequinar-sodium-d-3
Research Labs and Institutes | Johns Hopkins MedicineResearch Labs and Institutes | Johns Hopkins Medicine
He performed several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting ...
https://www.hopkinsmedicine.org/research/research_lab_results.html?query=molecular%20genetics&pagesize=10&page=2
David Jacobs - Research output - Experts@MinnesotaDavid Jacobs - Research output - [email protected]
Ding, J., Reynolds, L. M., Zeller, T., Müller, C., Lohman, K., Nicklas, B. J., Kritchevsky, S. B., Huang, Z., De La Fuente, A., Soranzo, N., Settlage, R. E., Chuang, C. C., Howard, T., Xu, N., Goodarzi, M. O., Chen, Y. D. I., Rotter, J. I., Siscovick, D. S., Parks, J. S., Murphy, S., & 9 othersJacobs, D. R., Post, W., Tracy, R. P., Wild, P. S., Blankenberg, S., Hoeschele, I., Herrington, D., McCall, C. E. & Liu, Y., Oct 2015, In: Diabetes. 64, 10, p. 3464-3474 11 p.. Research output: Contribution to journal › Article › peer-review ...
https://experts.umn.edu/en/persons/david-jacobs/publications/?ordering=type&descending=false
An electrochemical method for sensitive and rapid detection of FAM134B protein in colon cancer samples.<...An electrochemical method for sensitive and rapid detection of FAM134B protein in colon cancer samples.<...
Colonic Neoplasms Medicine & Life Sciences 100% * Proteins Medicine & Life Sciences 40% * Enzyme-Linked Immunosorbent Assay ...
https://research.tees.ac.uk/en/publications/an-electrochemical-method-for-sensitive-and-rapid-detection-of-fa
Nicholas Rattray - Research output - University of StrathclydeNicholas Rattray - Research output - University of Strathclyde
Colonic Neoplasms 96% * Womens Rights 54% * Colorectal Neoplasms 50% * Aspartate-Ammonia Ligase 36% ...
https://pureportal.strath.ac.uk/en/persons/nicholas-rattray/publications/
Chemically modified antisense oligonucleotide against ARL4C inhibits primary and metastatic liver tumor growth - Fingerprint ...
Colonic Neoplasms 4% * Cultured Cells 4% * Small Interfering RNA 4% * Cell Movement 4% ...
https://kyushu-u.pure.elsevier.com/en/publications/chemically-modified-antisense-oligonucleotide-against-arl4c-inhib/fingerprints/
Dietary Fibre Intake and Risks of Cancers of the Colon and Rectum in the European Prospective Investigation into Cancer and...
Rectal Neoplasms Medicine & Life Sciences 83% * Colonic Neoplasms Medicine & Life Sciences 74% ...
https://research.wur.nl/en/publications/dietary-fibre-intake-and-risks-of-cancers-of-the-colon-and-rectum
ColonNeoplasticCancerDiseasesRenalAcuteTumors1980InvasionChronicSearchAdenocarcinomaCarcinomaAdenomaCancerEpithelialRecurrenceLymphomaAdenomasGastrointestinalAntigensOccurrence of colonicTumorGrowthMucosaHuman colonicMalignant neoplasmsCancersDetectionLungColorectal neoplasmDiagnosis
Colon4
  • Colonic neoplasm means "new tissue" growing in the colon, or large intestine. (givingtuesdaykz.com)
  • Objetivo: desarrollar una guía de práctica clínica con la evidencia más reciente para la tamización de cáncer de colon y recto en población asintomática de riesgo promedio, dirigida a pacientes, personal asistencial, administrativo y entes gubernamentales de cualquier servicio de atención en Col. (bvsalud.org)
  • Diverticular disease of the colon begins as diverticulosis (colonic outpouchings), which may develop into diverticulitis (diverticular inflammation and perforation). (medscape.com)
  • However, colon cancer certainly occurs in younger adults and even rarely in teenagers, while a previous screening colonoscopy may have missed a neoplasm. (medscape.com)
Neoplastic2
  • The findings of the present study thus allow us to propose a molecular mechanism involving c-Src activation in the process of malignant transformation of the human colonic neoplastic cells. (fujita-hu.ac.jp)
  • Photomicrograph of a section of the abdominal mass from the dog in Figure 1 , depicting neoplastic infiltration of the colonic serosa and tunica muscularis. (avma.org)
Cancer1
Diseases1
  • Computed tomography (CT) of the abdomen and pelvis with IV contrast is considered to be the best imaging method because it can confirm the presence of acute colonic diverticulitis, evaluate disease severity and degree, and often differentiate colonic diverticulitis from other diseases. (medscape.com)
Renal1
  • Because renal neoplasms often are asymptomatic during the growth phase, an earlier onset of fibrofolliculomas and trichodiscomas may serve as a marker. (medscape.com)
Acute1
  • Patients with acute colonic diverticulitis may have severe and prolonged lower abdominal pain due to diverticular inflammation that is usually associated with change in bowel movements, fever, and leukocytosis. (medscape.com)
Tumors1
  • Results A total of 144 patients had obstructive colonic tumors while 254 had nonobstructive tumors and constituted the control group. (bgu.ac.il)
19801
  • 1980. Inhibition by bran of the colonic cocarcinogenicity of bile salts in rats given dimethylhydrazine. (cdc.gov)
Invasion1
  • The stagnation of nonsterile inspissated fecal material, termed a fecalith, within the diverticulum may compromise the blood supply to the thin-walled sac and render it susceptible to invasion by colonic bacteria, causing inflammatory erosion of the mucosal lining and perforation. (medscape.com)
Chronic1
  • The answers to these questions may suggest chronic laxative abuse or less common causes, such as colonic outlet obstruction. (medscape.com)
Search1
  • Results of search for 'su:{Colonic neoplasms. (who.int)
Adenocarcinoma9
  • Other gastric conditions etiologically associated with H. pylori , such as intestinal metaplasia, adenoma, lymphoma, and adenocarcinoma, were also significantly associated with an increased risk of colonic neoplasm. (medscape.com)
  • Total proctocolectomy is often curative, alleviating symptoms and removing the risk of colonic adenocarcinoma . (medscape.com)
  • Colonic dysplasia is a precursor to adenocarcinoma and occurs in patients with UC. (medscape.com)
  • However, surveillance colonoscopy must be undertaken with caution, because even low-grade dysplasia is associated with synchronous adenocarcinoma in as many as 42% of cases, and as many as 84% of neoplasms in persons with UC are missed at random biopsy. (medscape.com)
  • In dogs, adenocarcinoma is the most common gastric and large intestinal neoplasm, whereas lymphoma is more frequently seen in the small intestine , followed by adenocarcinoma and sarcomas such as gastrointestinal stromal tumor (GIST) and leiomyosarcoma. (msdvetmanual.com)
  • In cats, lymphoma is the most common GI neoplasm , followed by adenocarcinoma and mast cell tumor. (msdvetmanual.com)
  • A 74-year-old man suffered from jejunal perforation and adhesion to sigmoid colon due to adenocarcinoma associated with intraductal papillary mucinous neoplasm (IPMN) arising in a jejunal heterotopic pancreas. (jpatholtm.org)
  • Furthermore, we have not found any report regarding an adenocarcinoma associated with intraductal papillary mucinous neoplasm (IPMN) in a heterotopic pancreas. (jpatholtm.org)
  • Newly Diagnosed Colonic Adenocarcinoma: The Presenting Sign in a Young Woman with Undiagnosed Crohn's Disease in the Absence of Primary Sclerosing Cholangitis and a Normal Microsatellite Instability Profile. (ucsd.edu)
Carcinoma2
  • Most invasive CRCs develop from intraepithelial neoplasms (adenomas), although the adenoma to carcinoma sequence may take 10 years (2) . (aacrjournals.org)
  • We report a case of colonic plasmacytoma which presented with bleeding per rectum and was initially misdiagnosed as colonic neuroendocrine carcinoma. (hindawi.com)
Adenoma3
  • Pooled miRNAs for CRC had an AUC of 0.811, with a sensitivity of 58.8% (95% confidence interval [CI]: 51.7-65.5%) and specificity of 84.8% (95% CI: 81.1-87.8%), whilst for colonic adenoma, it was 0.747, 57.3% (95% CI: 40.8-72.3%) and 76.1% (95% CI: 66.1-89.4%), respectively. (sruc.ac.uk)
  • With this new application, the system's sophisticated machine learning can alert the endoscopist in real time when a suspected colonic lesion (such as a polyp, malignant neoplasm or adenoma) appears on the screen. (seanewswire.com)
  • Micrograph of a tubular adenoma (left of image), a type of colonic polyp and a precursor of colorectal cancer. (icd.codes)
Cancer6
  • In colon cancer, we have shown a pattern of age-related methylation for several genes, including ER, IGF2, N33 and MyoD, which progresses to full methylation in adenomas and neoplasms. (elsevier.com)
  • However, colon cancer certainly occurs in younger adults and even rarely in teenagers, while a previous screening colonoscopy may have missed a neoplasm. (medscape.com)
  • Previously, we reported that aldehyde dehydrogenase (ALDH) and other RA pathway components are co-expressed in colonic cancer SCs (CSCs) and that overpopulation of ALDH-positive CSCs occurs during colon tumorigenesis. (jefferson.edu)
  • Lung cancer is reported as the most common neoplasm in human world-wide. (spandidos-publications.com)
  • Presently, carnosic acid has been suggested to possess some antitumor properties in mammary tumors, colonic cancer, as well as skin tumors via regulation of cell growth and apoptosis. (spandidos-publications.com)
  • Colonic are bladder papillomas cancerous during treatment of radiotherapy complications in prostatic cancer. (calorifere-fonta.ro)
Epithelial1
  • Colonic tumorigenesis involves the processes of initiation and promotion/progression from normal epithelial cells to tumors. (aacrjournals.org)
Recurrence2
  • Later the patient presented with recurrence of the colonic mass along with multiple lytic bone lesions. (hindawi.com)
  • It was diagnosed as a recurrence of the initial colonic mass. (hindawi.com)
Lymphoma1
  • Non-Hodgkin lymphoma is the most common type of colonic lymphoma and represents less than 0.5% of colorectal neoplasms. (physiciansweekly.com)
Adenomas2
  • Similarly, the strength of the association between H. pylori- positive gastritis and colonic neoplasm increased with size and number of the adenomas. (medscape.com)
  • Obese patients consistently exhibit a higher prevalence of colonic adenomas than non-obese controls[5,6]. (ghrnet.org)
Gastrointestinal4
  • In this article I review the association between exposure to carrageenan and the occurrence of colonic ulcerations and gastrointestinal neoplasms in animal models. (nih.gov)
  • Classify here works on gastrointestinal neoplasms. (nih.gov)
  • It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. (lookformedical.com)
  • Many gastrointestinal neoplasms in dogs and cats are biologically aggressive with a poor outcome, even with surgical and medical therapy. (msdvetmanual.com)
Antigens1
  • 9. Antigen expression in normal and neoplastic colonic mucosa: three tissue-specific antigens using monoclonal antibodies to isolated colonic glands. (nih.gov)
Occurrence of colonic2
  • The association between H. pylori gastritis and the occurrence of colonic neoplasm was similar for different locations of the large bowel. (medscape.com)
  • [ 1 , 2 ] These previous studies relied on different variables to assess risk factors and the occurrence of colonic neoplasm. (medscape.com)
Tumor2
  • In summary, UDCA significantly inhibited AOM-induced colonic carcinogenesis during either tumor initiation or in the promotion/progression phase. (aacrjournals.org)
  • Hereditary Wilms' Tumor Familial embryonal neoplasm derived from nephrogenic blastemal cells. (nih.gov)
Growth1
  • These findings indicate that the expression of HOXA9 and its functional network is regulated by RA signaling in normal colonic SCs, and, when dysregulated, HOXA9 may contribute to CSC overpopulation that drives CRC development and growth. (jefferson.edu)
Mucosa5
  • 19. Immunohistochemical changes in morphologically involved and uninvolved colonic mucosa of patients with idiopathic proctitis. (nih.gov)
  • An upwards shift of the proliferative compartment in colonic crypts is reported to be one of the earliest changes in premalignant mucosa. (bmj.com)
  • In normal colonic mucosa the proliferative compartment is confined to the lower half to two thirds of the crypt. (bmj.com)
  • 2-14 These studies suggested that the whole of the colonic mucosa expresses proliferative abnormalities-that is, there is a field change rather than a focal change. (bmj.com)
  • Biologic mechanisms may also increase CRC risk for people with diabetes (1-3), possibly because increased exposure of colonic mucosa to carcinogens caused by slower bowel transit times increases fecal bile acids associated with blood glucose and triglycerides (1). (cdc.gov)
Human colonic1
  • It is also highly expressed in the human colonic adenocarcinomas. (nih.gov)
Malignant neoplasms1
  • Designed to offer the ultimate combination of delivery system access and stent construction to expand options available for patient treatment and management of colonic strictures caused by malignant neoplasms. (bostonscientific.com)
Cancers1
  • Of the 195 patients with focal colonic 18F-FDG activity, 103 patients (52.8 %) had 145 advanced colonic neoplasms, including 58 colon cancers and 11 metastatic cancers. (springernature.com)
Detection1
  • A number of studies were reviewed, including the results of clinical trials for occult blood testing for detection of colonic neoplasms in the U.S. and Germany. (nih.gov)
Lung1
  • Oral exposure of mice to IQ induces increased incidences of neoplasms of the lung, liver, and forestomach in males and females. (nih.gov)
Colorectal neoplasm3
  • In the past, when H. pylori infection was more prevalent, its attributable risk to the occurrence of colorectal neoplasm may have been quite substantial. (medscape.com)
  • Patients and methods Patients with a history of colorectal neoplasm were eligible. (thieme-connect.de)
  • Zhang S, Peng JW, Shi QY, Tang F, Zhong MG. Colorectal neoplasm: Magnetic resonance colonography with fat enema-initial clinical experience. (wjgnet.com)
Diagnosis2
  • The diagnosis of colonic plasmacytoma with progression into multiple myeloma was given. (hindawi.com)
  • To code a diagnosis of this type, you must use one of the ten child codes of D12 that describes the diagnosis 'benign neoplasm of colon, rectum, anus and anal canal' in more detail. (icd.codes)
Laparoscopic-Assisted Surgery Compared With Open Surgery in Treating Patients With Colon Cancer - Full Text View -...
Laparoscopic-Assisted Surgery Compared With Open Surgery in Treating Patients With Colon Cancer - Full Text View -... (clinicaltrials.gov)
Colorectal Cancer | Colon Cancer | Rectal Cancer | MedlinePlus
Colorectal Cancer | Colon Cancer | Rectal Cancer | MedlinePlus (medlineplus.gov)
Birt-Hogg-Dube Syndrome (BHDS) Workup: Imaging Studies, Other Tests, Procedures
Birt-Hogg-Dube Syndrome (BHDS) Workup: Imaging Studies, Other Tests, Procedures (medscape.com)
Plau (plasminogen activator, urokinase) - Rat Genome Database
Plau (plasminogen activator, urokinase) - Rat Genome Database (rgd.mcw.edu)
Medical Microbiology<...
Medical Microbiology<... (portal.research.lu.se)
Gastroenterology and Hepatology - Research output - Mayo Clinic
Gastroenterology and Hepatology - Research output - Mayo Clinic (mayoclinic.pure.elsevier.com)
Larry M Karnitz - Research output - Mayo Clinic
Larry M Karnitz - Research output - Mayo Clinic (mayoclinic.pure.elsevier.com)
Stephen M Hewitt - Google Scholar
Stephen M Hewitt - Google Scholar (scholar.google.de)
David Jacobs - Research output - Experts@Minnesota
David Jacobs - Research output - [email protected] (experts.umn.edu)
Lower Gastrointestinal Bleeding Clinical Presentation: History, Physical Examination
Lower Gastrointestinal Bleeding Clinical Presentation: History, Physical Examination (medscape.com)
Colonic Infiltration With Chronic Myelomonocytic Leukaemia
Colonic Infiltration With Chronic Myelomonocytic Leukaemia (medscape.com)
An electrochemical method for sensitive and rapid detection of FAM134B protein in colon cancer samples.<...
An electrochemical method for sensitive and rapid detection of FAM134B protein in colon cancer samples.<... (research.tees.ac.uk)
Chemically modified antisense oligonucleotide against ARL4C inhibits primary and metastatic liver tumor growth - Fingerprint ...
Chemically modified antisense oligonucleotide against ARL4C inhibits primary and metastatic liver tumor growth - Fingerprint ... (kyushu-u.pure.elsevier.com)
Professor Robyn Ward
Professor Robyn Ward (unsw.edu.au)
Dietary Fibre Intake and Risks of Cancers of the Colon and Rectum in the European Prospective Investigation into Cancer and...
Dietary Fibre Intake and Risks of Cancers of the Colon and Rectum in the European Prospective Investigation into Cancer and... (research.wur.nl)
Helicobacter pylori Is a Risk Factor for Colonic Neoplasms
Helicobacter pylori Is a Risk Factor for Colonic Neoplasms (medscape.com)
PubMed: Searching Using Subsets. NLM Technical Bulletin. Jan-Feb 1999
PubMed: Searching Using Subsets. NLM Technical Bulletin. Jan-Feb 1999 (nlm.nih.gov)
Taste System Anatomy: Overview, Gross Anatomy, Microscopic Anatomy
Taste System Anatomy: Overview, Gross Anatomy, Microscopic Anatomy (emedicine.medscape.com)
A Proximal Ascending Colon Lesion of a Crohn Disease Patient
A Proximal Ascending Colon Lesion of a Crohn Disease Patient (medscape.com)
Birt-Hogg-Dube Syndrome (BHDS) Clinical Presentation: History, Physical Examination
Birt-Hogg-Dube Syndrome (BHDS) Clinical Presentation: History, Physical Examination (medscape.com)