Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).
A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
A solution or compound that is introduced into the RECTUM with the purpose of cleansing the COLON or for diagnostic procedures.
Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.
Tumors or cancer of the COLON.
Discrete tissue masses that protrude into the lumen of the COLON. These POLYPS are connected to the wall of the colon either by a stalk, pedunculus, or by a broad base.

Reconstruction for chronic dysfunction of ileoanal pouches. (1/670)

OBJECTIVE: A retrospective review was performed to determine the results after surgical reconstruction for chronic dysfunction of ileal pouch-anal procedures for ulcerative colitis and familial colonic polyposis at a university medical center. METHODS: During the 20-year period from 1978 to 1998, 601 patients underwent colectomy and ileal pouch-anal anastomosis (IPAA) for ulcerative colitis, familial colonic polyposis, or Hirschsprung's disease. A J pouch was used for 351 patients, a lateral pouch for 221, an S pouch for 6, and a straight pull-through for 23. Acute complications after pouch construction have been detailed in previous publications and are not included in this study. Chronic pouch stasis with diarrhea, frequency, urgency, and soiling gradually became more severe in 164 patients (27.3%), associated with pouch enlargement, an elongated efferent limb, and obstruction to pouch outflow, largely related to the pouch configuration used during the authors' early clinical experience. These patients were sufficiently symptomatic to be considered for reconstruction (mean 68 months after IPAA). Transanal resection of an elongated IPAA spout was performed on 58 patients; abdominoperineal mobilization of the pouch with resection and tapering of the lower end (AP reconstruction) and ileoanal anastomosis on 83; pouch removal and new pouch construction on 7; and conversion of a straight pull-through to a pouch on 16. RESULTS: Good long-term results (mean 7.7 years) with improvement in symptoms occurred in 98% of transanal resections, 91.5% of AP reconstructions, 86% of new pouch constructions, and 100% of conversions of a straight pull-through to a pouch. The average number of bowel movements per 24 hours at 6 months was 4.8. Complications occurred in 11.6% of reconstructed patients. Five of the 164 patients (3.1%) required eventual pouch removal and permanent ileostomy. The high rate of pouch revision in this series of patients undergoing IPAA is due to a policy of aggressive correction when patients do not experience an optimal functional result, or have a progressive worsening of their status. CONCLUSIONS: Although occasionally a major undertaking, reconstruction of ileoanal pouches with progressive dysfunction due to large size or a long efferent limb has resulted in marked improvement in intestinal function in >93% of patients and has reduced the need for late pouch removal.  (+info)

The pathophysiology of disseminated Mycobacterium avium complex disease in AIDS. (2/670)

Mycobacterium avium complex (MAC) organisms cause disseminated disease in patients with AIDS. The organisms penetrate the gastrointestinal mucosa by unknown mechanisms and are phagocytosed by macrophages in the lamina propria. These cells cannot kill the organisms, and MAC spreads through the submucosal tissue. Lymphatic drainage transports mycobacteria to abdominal lymph nodes, from which the organisms enter the bloodstream. Hematogenous spread can occur to many sites, but spleen, bone marrow, and liver are the most common. Tissue destruction is rare, and most signs and symptoms of MAC disease are due to elaboration of cytokines. MAC is rarely the direct cause of death but increases the risk for superinfection; death may result from malnutrition or other infections.  (+info)

Psoas abscesses complicating colonic disease: imaging and therapy. (3/670)

Most surgeons think of psoas abscesses as a very rare condition related to tuberculosis of the spine, but in contemporary surgical practice they are more usually a complication of gastrointestinal disease. A case note study was undertaken on all patients treated for psoas abscess at two large hospitals in the mid-Trent region over a 2-year period. All seven patients presented with pyrexia, psoas spasm, a tender mass and leucocytosis. The diagnosis was made on abdominal radiographs in one patient, CT scan in three, MRI in two, and ultrasound in one. Aetiological factors included Crohn's disease in three, appendicitis in two, and sigmoid diverticulitis and metastatic colorectal carcinoma in one each. Six patients underwent transabdominal resection of the diseased bowel, retroperitoneal debridement and external drainage of the abscess cavity. Percutaneous drainage was performed in one. Two patients had more than one surgical exploration for complications. There were no deaths and the hospital stay ranged from 8-152 days. Psoas abscess can be a difficult and protracted problem. Bowel resection, thorough debridement, external drainage and concomitant antibiotics are essential for psoas abscesses complicating gastrointestinal disease. Defunctioning stomas may be necessary. However, in some cases a multidisciplinary approach may be required, as psoas abscesses can involve bone and joints.  (+info)

The colonic mesenteric margin is most susceptible to injury in an experimental model of colonic ulceration. (4/670)

BACKGROUND: Crohn's disease ileal ulcers and indomethacin-induced jejunal ulceration in the rat tend to occur in the mucosa nearest to the mesentery (mesenteric margin), an area of the bowel wall that has a critical blood supply. Mercuric chloride induces caecal and colonic ulceration in the Brown Norway rat. AIM: To examine whether the mesenteric margin is more sensitive to injury by a substance known to be vasculotoxic in the caecum and colon. METHODS: Brown Norway rats received a single subcutaneous dose of either mercuric chloride 1 mg/kg or saline. The gastrointestinal tract was examined macro- and microscopically for lesions 48 h later. The vascular anatomy of the normal rat colon and caecum was also examined using the carbon ink perfusion technique. RESULTS: Mercuric chloride induced caecal and colonic ulceration preferentially along the mesenteric margin of the bowel wall. Histologically, the lesions showed mucosal necrosis and neutrophil infiltration. There was also extensive vascular degeneration/necrosis with microaneurysm formation and extensive submucosal haemorrhage. Cellular infiltration of the vasculature was not a feature. The caecal and colonic mesenteric margins in control rats were supplied by small end arteries. CONCLUSIONS: The colonic and caecal mesenteric margins are susceptible to injury by mercuric chloride, a chemical known to induce haemorrhagic vasculopathy in the rat gastrointestinal tract. The large bowel mesenteric margin may be susceptible to injury by mercuric chloride because of the critical blood supply to that side of the bowel wall.  (+info)

Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor. (5/670)

Inducible nitric oxide synthase (iNOS) is overexpressed in colonic tumors of humans and also in rats treated with a colon carcinogen. iNOS appear to regulate cyclooxygenase-2 (COX-2) expression and production of proinflammatory prostaglandins, which are known to play a key role in colon tumor development. Experiments were designed to study the inhibitory effects of S,S'-1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea (PBIT) a selective iNOS-specific inhibitor, measured against formation of azoxymethane (AOM)-induced colonic aberrant crypt foci (ACF). Beginning at 5 weeks of age, male F344 rats were fed experimental diets containing 0 or 50 p.p.m. of PBIT, or 2000 p.p.m. of curcumin (non-specific iNOS inhibitor). One week later, rats were injected s.c. with AOM (15 mg/kg body wt, once weekly for 2 weeks). At 17 weeks of age, all rats were killed, colons were evaluated for ACF formation and colonic mucosa was assayed for isoforms of COX and NOS activities. Both COX and iNOS activities in colonic mucosa of the AOM-treated rats were significantly induced. Importantly, 50 p.p.m. PBIT suppressed AOM-induced colonic ACF formation to 58% (P < 0.0001) and crypt multiplicity containing four or more crypts per focus to 78% (P < 0.0001); it also suppressed AOM-induced iNOS activity. Curcumin inhibited colonic ACF formation by 45% (P < 0.001). These observations suggest that iNOS may play a key regulatory role in colon carcinogenesis. Developing iNOS-specific inhibitors may provide a selective and safe chemopreventive strategy for colon cancer treatment.  (+info)

Dietary n-3 PUFA increases the apoptotic response to 1,2-dimethylhydrazine, reduces mitosis and suppresses the induction of carcinogenesis in the rat colon. (6/670)

The effect of dietary fish oil on colonic crypt cell apoptosis and proliferation was examined in male Wistar rats, 24 and 48 h after administration of 1,2-dimethylhydrazine (DMH), and its influence on the induction of aberrant crypt foci (ACF) in the distal colon was assessed. Rats (125-150 g) fed a high-fat semi-synthetic diet containing corn oil (CO) were given DMH (30 mg/kg body wt) or a sham injection of EDTA/NaCl. Animals were then fed either the CO diet or a diet in which fish oil (EPA 18.7%; DHA 8%) was substituted for corn oil. Subgroups of rats (n = 5) were killed after 24 and 48 h, and crypt cell apoptosis and proliferation were quantified by morphological criteria in isolated intact crypts from the mid and distal colon. Consumption of the fish oil diet (FO) was associated with increased apoptotic cell death (P < 0.001) and suppression of proliferation (P < 0.05) in colonic crypts both 24 and 48 h after DMH. In a second experiment, animals were given three injections of DMH or sham injections of carrier at weekly intervals. For 48 h after each injection animals were fed either the CO or FO diet, but otherwise maintained on the CO throughout. The number and crypt multiplicity of ACF in the distal colon were determined after 18 weeks, and animals given the FO diet for the 48 h period following carcinogen administration were found to have significantly fewer ACF than rats fed the CO diet (P < 0.05). The data demonstrate that the fatty acid composition of the diet is an important determinant in the induction of carcinogenesis by DMH. The proliferative and apoptotic response of the colonic crypt to carcinogen and fish oil, coupled with the reduced incidence of ACF, suggest n-3 PUFA can protect against the carcinogenic effects of DMH by mediating changes in the balance proliferation and cell death.  (+info)

Laparoscopic-assisted colectomy: a comparison of dissection techniques. (7/670)

BACKGROUND AND OBJECTIVES: Mobilization of the colon and dissection of the mesentery are difficult laparoscopic techniques. Traditional methods have been used for this dissection, but often with great difficulty. The ultrasonically activated shears, when introduced in 1993, had the possibility to make this dissection less technically difficult. This is a retrospective review of the use of these shears for these techniques during laparoscopic-assisted colectomy. MATERIALS AND METHODS: Eighty-five patients underwent a laparoscopic-assisted right hemicolectomy or sigmoid resection. Colon mobilization and mesenteric dissection were completed intracorporeally. Complications, operative time, estimated blood loss, and length of stay were compared for resections completed with and without the ultrasonically activated shears. RESULTS: Thirty-six patients had laparoscopic-assisted colectomy without the shears, and 49 patients had the procedure with the shears. There were no complications due to the ultrasonic energy. Use of the shears resulted in shorter operative times (170 min. vs. 187 min., p=0.1989), similar median blood loss (98 mL vs. 95 mL, p=0.7620), and shorter lengths of stay (4.3 days vs. 6.9 days, p=0.0018). CONCLUSIONS: The ultrasonically activated shears are safe and effective for colon mobilization and mesenteric division. The use of the shears may result in shorter operative times and shorter lengths of stay.  (+info)

Laparoscopic colon surgery for benign disease: a comparison to open surgery. (8/670)

BACKGROUNDS AND OBJECTIVES: There remains a debate in the literature about the advisability of laparoscopic surgery for malignant disease of the colon. Current prospective studies will hopefully answer this question. However, for benign diseases of the colon, we believe laparoscopic surgery offers many advantages including decreased postoperative pain, early discharge from the hospital, and early return to normal activities. We retrospectively reviewed our experience with laparoscopic colectomies for benign disease to see whether these procedures could be done safely and if the proposed advantages could be realized. METHODS: Thirty-eight laparoscopic colon resections performed for benign disease were compared to 39 open colon resections with respect to operating times, length of hospital stay, estimated blood loss, days until first postoperative bowel movement, and complications. RESULTS: The laparoscopic colon resection group had decreased length of stay, less blood loss, earlier return of bowel function, and an equivalent number of complications. Laparoscopic cases did take an average of 24 minutes longer. CONCLUSION: The use of laparoscopic colon surgery for benign disease not only affords the patient the advantage of the laparoscopic approach, but also allows the surgeon to gain experience while awaiting the results of ongoing trials for laparoscopic colon surgery in malignant disease.  (+info)

Colonic diseases refer to a group of medical conditions that affect the colon, also known as the large intestine or large bowel. The colon is the final segment of the digestive system, responsible for absorbing water and electrolytes, and storing and eliminating waste products.

Some common colonic diseases include:

1. Inflammatory bowel disease (IBD): This includes conditions such as Crohn's disease and ulcerative colitis, which cause inflammation and irritation in the lining of the digestive tract.
2. Diverticular disease: This occurs when small pouches called diverticula form in the walls of the colon, leading to symptoms such as abdominal pain, bloating, and changes in bowel movements.
3. Colorectal cancer: This is a type of cancer that develops in the colon or rectum, often starting as benign polyps that grow and become malignant over time.
4. Irritable bowel syndrome (IBS): This is a functional gastrointestinal disorder characterized by abdominal pain, bloating, and changes in bowel movements, but without any underlying structural or inflammatory causes.
5. Constipation: This is a common condition characterized by infrequent bowel movements, difficulty passing stools, or both.
6. Infectious colitis: This occurs when the colon becomes infected with bacteria, viruses, or parasites, leading to symptoms such as diarrhea, abdominal cramps, and fever.

Treatment for colonic diseases varies depending on the specific condition and its severity. Treatment options may include medications, lifestyle changes, surgery, or a combination of these approaches.

Crohn's disease is a type of inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal tract, from the mouth to the anus. It is characterized by chronic inflammation of the digestive tract, which can lead to symptoms such as abdominal pain, diarrhea, fatigue, weight loss, and malnutrition.

The specific causes of Crohn's disease are not fully understood, but it is believed to be related to a combination of genetic, environmental, and immune system factors. The disease can affect people of any age, but it is most commonly diagnosed in young adults between the ages of 15 and 35.

There is no cure for Crohn's disease, but treatments such as medications, lifestyle changes, and surgery can help manage symptoms and prevent complications. Treatment options depend on the severity and location of the disease, as well as the individual patient's needs and preferences.

The colon, also known as the large intestine, is a part of the digestive system in humans and other vertebrates. It is an organ that eliminates waste from the body and is located between the small intestine and the rectum. The main function of the colon is to absorb water and electrolytes from digested food, forming and storing feces until they are eliminated through the anus.

The colon is divided into several regions, including the cecum, ascending colon, transverse colon, descending colon, sigmoid colon, rectum, and anus. The walls of the colon contain a layer of muscle that helps to move waste material through the organ by a process called peristalsis.

The inner surface of the colon is lined with mucous membrane, which secretes mucus to lubricate the passage of feces. The colon also contains a large population of bacteria, known as the gut microbiota, which play an important role in digestion and immunity.

An enema is a medical procedure in which liquid is introduced into the lower part of the large intestine, specifically the sigmoid colon or rectum, through the anus using a special device called an enema kit. The liquid used can be plain water, saline solution, or a medicated solution, and it is typically retained for a short period of time before being expelled.

The purpose of an enema may vary, but it is often used to relieve constipation, prepare the bowel for medical procedures such as colonoscopy, or administer medications or nutrients that cannot be taken by mouth. Enemas can also be used for therapeutic purposes, such as to stimulate the immune system or promote relaxation.

It is important to follow proper instructions when administering an enema to avoid injury or discomfort. Possible side effects of enemas may include cramping, bloating, nausea, or electrolyte imbalances. If you have any health concerns or conditions that may be affected by an enema, it is recommended to consult with a healthcare professional before using one.

Ulcerative colitis is a type of inflammatory bowel disease (IBD) that affects the lining of the large intestine (colon) and rectum. In ulcerative colitis, the lining of the colon becomes inflamed and develops ulcers or open sores that produce pus and mucous. The symptoms of ulcerative colitis include diarrhea, abdominal pain, and rectal bleeding.

The exact cause of ulcerative colitis is not known, but it is thought to be related to an abnormal immune response in which the body's immune system attacks the cells in the digestive tract. The inflammation can be triggered by environmental factors such as diet, stress, and infections.

Ulcerative colitis is a chronic condition that can cause symptoms ranging from mild to severe. It can also lead to complications such as anemia, malnutrition, and colon cancer. There is no cure for ulcerative colitis, but treatment options such as medications, lifestyle changes, and surgery can help manage the symptoms and prevent complications.

The rectum is the lower end of the digestive tract, located between the sigmoid colon and the anus. It serves as a storage area for feces before they are eliminated from the body. The rectum is about 12 cm long in adults and is surrounded by layers of muscle that help control defecation. The mucous membrane lining the rectum allows for the detection of stool, which triggers the reflex to have a bowel movement.

A colonoscopy is a medical procedure used to examine the large intestine, also known as the colon and rectum. It is performed using a flexible tube with a tiny camera on the end, called a colonoscope, which is inserted into the rectum and gently guided through the entire length of the colon.

The procedure allows doctors to visually inspect the lining of the colon for any abnormalities such as polyps, ulcers, inflammation, or cancer. If any polyps are found during the procedure, they can be removed immediately using special tools passed through the colonoscope. Colonoscopy is an important tool in the prevention and early detection of colorectal cancer, which is one of the leading causes of cancer-related deaths worldwide.

Patients are usually given a sedative to help them relax during the procedure, which is typically performed on an outpatient basis in a hospital or clinic setting. The entire procedure usually takes about 30-60 minutes to complete, although patients should plan to spend several hours at the medical facility for preparation and recovery.

The intestinal mucosa is the innermost layer of the intestines, which comes into direct contact with digested food and microbes. It is a specialized epithelial tissue that plays crucial roles in nutrient absorption, barrier function, and immune defense. The intestinal mucosa is composed of several cell types, including absorptive enterocytes, mucus-secreting goblet cells, hormone-producing enteroendocrine cells, and immune cells such as lymphocytes and macrophages.

The surface of the intestinal mucosa is covered by a single layer of epithelial cells, which are joined together by tight junctions to form a protective barrier against harmful substances and microorganisms. This barrier also allows for the selective absorption of nutrients into the bloodstream. The intestinal mucosa also contains numerous lymphoid follicles, known as Peyer's patches, which are involved in immune surveillance and defense against pathogens.

In addition to its role in absorption and immunity, the intestinal mucosa is also capable of producing hormones that regulate digestion and metabolism. Dysfunction of the intestinal mucosa can lead to various gastrointestinal disorders, such as inflammatory bowel disease, celiac disease, and food allergies.

Functional colonic diseases are a group of disorders of the large intestine (colon) that do not have a structural or biochemical explanation. They are characterized by chronic and often intermittent symptoms, such as abdominal pain, bloating, and changes in bowel habits, but do not show any visible abnormalities or damage to the tissue of the colon during routine examination or testing.

The most common functional colonic diseases include:

1. Irritable Bowel Syndrome (IBS): A disorder characterized by recurrent abdominal pain, bloating, and changes in bowel habits, such as constipation or diarrhea.
2. Functional Constipation: A condition where a person experiences difficult or infrequent bowel movements, but there is no obvious structural or biochemical cause.
3. Functional Diarrhea: A disorder characterized by frequent loose stools, but without any underlying structural or biochemical abnormalities.
4. Abdominal Bloating: A condition where the belly feels full and tight, often accompanied by discomfort or pain, but without any visible distention.
5. Functional Abdominal Pain Syndrome: A disorder characterized by chronic or recurrent abdominal pain that is not associated with any structural or biochemical abnormalities.

The exact cause of functional colonic diseases is unknown, but they are believed to be related to a combination of factors, including genetics, environmental factors, altered gut motility, visceral hypersensitivity, and psychological factors such as stress and anxiety. Treatment typically involves lifestyle modifications, such as changes in diet and exercise, and medication to manage symptoms.

Colonic neoplasms refer to abnormal growths in the large intestine, also known as the colon. These growths can be benign (non-cancerous) or malignant (cancerous). The two most common types of colonic neoplasms are adenomas and carcinomas.

Adenomas are benign tumors that can develop into cancer over time if left untreated. They are often found during routine colonoscopies and can be removed during the procedure.

Carcinomas, on the other hand, are malignant tumors that invade surrounding tissues and can spread to other parts of the body. Colorectal cancer is the third leading cause of cancer-related deaths in the United States, and colonic neoplasms are a significant risk factor for developing this type of cancer.

Regular screenings for colonic neoplasms are recommended for individuals over the age of 50 or those with a family history of colorectal cancer or other risk factors. Early detection and removal of colonic neoplasms can significantly reduce the risk of developing colorectal cancer.

Colonic polyps are abnormal growths that protrude from the inner wall of the colon (large intestine). They can vary in size, shape, and number. Most colonic polyps are benign, meaning they are not cancerous. However, some types of polyps, such as adenomas, have a higher risk of becoming cancerous over time if left untreated.

Colonic polyps often do not cause any symptoms, especially if they are small. Larger polyps may lead to symptoms like rectal bleeding, changes in bowel habits, abdominal pain, or iron deficiency anemia. The exact cause of colonic polyps is not known, but factors such as age, family history, and certain medical conditions (like inflammatory bowel disease) can increase the risk of developing them.

Regular screening exams, such as colonoscopies, are recommended for individuals over the age of 50 to detect and remove polyps before they become cancerous. If you have a family history of colonic polyps or colorectal cancer, your doctor may recommend earlier or more frequent screenings.

Timothy R. Koch (2003). Colonic diseases. Humana Press. pp. 387-. ISBN 978-0-89603-961-2. Retrieved 2010-11-12.[permanent dead ... "Hirschsprung's disease". Genetic and Rare Diseases Information Center (GARD) - an NCATS Program. 2017. Archived from the ... "Hirschsprung's disease". Mayo Clinic. Retrieved 30 January 2023. Heuckeroth RO (March 2018). "Hirschsprung disease - ... "Definition & Facts for Hirschsprung Disease - NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. ...
"Clinical manifestations and diagnosis of colonic diverticular disease". Literature review. "Diverticular Disease". www.niddk. ... Colonic perforation due to diverticular disease may be classified using the Hinchey Classification. The signs and symptoms of ... "Diverticular Disease". The Lecturio Medical Concept Library. Retrieved 12 July 2021. "Diverticular disease of the colon". The ... Diverticular disease is when problems occur due to diverticulosis, a condition defined by the presence of pouches in the wall ...
Anorectal and Colonic Diseases: A Practical Guide to their Management. Springer. ISBN 978-3-54069418-2. (Articles with short ... Ehrenpreis, Eli (2003). Anal and Rectal Diseases Explained. Remedica. ISBN 978-1-901346-67-1. Cohee, Mark W.; Hurff, Ashlee; ...
in 1978 classifies a colonic perforation due to diverticular disease. The classification is I-IV: Hinchey I - localised abscess ... Laparoscopic peritoneal lavage for perforated colonic diverticulitis: a systematic review. Colorectal Disease 12(9):862-7, 2010 ... Hinchey, E.J., Schaal, P.G. and Richard, G.K. Treatment of perforated diverticular disease of the colon. Advances in Surgery 12 ... para-colonic) Hinchey II - pelvic abscess Hinchey III - purulent peritonitis (the presence of pus in the abdominal cavity) ...
... , also called colonic diverticulitis, is a gastrointestinal disease characterized by inflammation of abnormal ... Pemberton, John H (16 June 2016). "Colonic diverticulosis and diverticular disease: Epidemiology, risk factors, and ... It is the most frequent anatomic disease of the colon. Costs associated with diverticular disease were around US $2.4 billion a ... Right-sided diverticula are micro-hernias of the colonic mucosa and submucosa through the colonic muscular layer where blood ...
Micro perforations with free air may be seen.[citation needed] Ulcerative colitis or Crohn's disease may cause colonic ... It has been associated to several diseases, including Huntington's disease. Laparotomy for other forms of volvulus, especially ... Although diverticulitis may be the source of a colonic obstruction, it more commonly causes an ileus, which appears to be a ... The medical history is helpful in that most cases of inflammatory bowel disease are well known to both patient and doctor. ...
Maladie d'Arbuthnot Lane)" [Colonic inertia and rectal obstruction (Arbuthnot Lane disease)]. Annales de Gastroentérologie et ... The syndrome that Lane reported in 1908, "Lane disease" or "Arbuthnot Lane disease", is now usually termed by ... "Lane's disease"-now otherwise termed colonic inertia, which he identified in 1908-which surgeries were controversial but ... Tracing diverse diseases to modern civilization, he urged the people to return to farmland. For his New Health, Lane eventually ...
"Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease". World Journal of ... Thus, altered IAP expression has been implicated in chronic inflammatory diseases such as inflammatory bowel disease (IBD). It ... Some diseases do not affect the levels of alkaline phosphatase, for example, hepatitis C. A high level of this enzyme does not ... Placental alkaline phosphatase is elevated in seminomas and active forms of rickets, as well as in the following diseases and ...
Large intestine: nonspecific ulcerative colitis, Crohn's disease, chronic colitis, colonic polyps, colorectal cancer, etc. The ... The laparoscopy: liver disease, biliary disease, etc. The respiratory tract: lung cancer, transbronchoscopy lung biopsy, ... Laparoscope was used in the diagnosis of liver and gallbladder disease by Heinz Kalk in the 1930s. Hope reported in 1937 on the ... It is meeting a growing demand to lessen the risk of cross contamination and hospital acquired diseases. A European consortium ...
"Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms". PLOS ONE. 5 (9): ... researchers have been using colonic biopsies of Parkinson's patients to help better understand and manage Parkinson's disease. ... Hirschsprung's disease is a congenital disorder of the colon in which nerve cells of the myenteric plexus in its walls, also ... Hirschsprung's disease is a form of functional low bowel obstruction due to failure of caudal migration of neuroblasts within ...
Colonoscopy is necessary in colonic and ileal disease. ERCP will show pancreatic and biliary structural abnormalities. 75SeHCAT ... OGD to detect duodenal pathology and obtain D2 biopsy (for coeliac disease, tropical sprue, Whipple's disease, ... as occurs in coeliac disease with extensive involvement of the small intestine. Depending on the nature of the disease process ... For example, pain is common in patients with chronic pancreatitis or pancreatic cancer and Crohn's disease, but it is absent in ...
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Humes D, Smith JK, Spiller RC (14 March 2011). "Colonic diverticular disease: medical treatments for acute diverticulitis". BMJ ... "Clinical manifestations and diagnosis of colonic diverticular disease". Literature review. Stefánsson T, Ekbom A, Sparèn P, ... Diverticular disease was found associated with a higher risk of left sided colon cancer. Diverticular disease can present with ... Pemberton, John H (16 June 2016). "Colonic diverticulosis and diverticular disease: Epidemiology, risk factors, and ...
It is used to treat inflammatory bowel disease, including ulcerative colitis and Crohn's disease (effective only in colonic ... including ulcerative colitis and Crohn's disease. It is generally used for mildly to moderately severe disease. It is taken by ... The drug should not be used in children under two years of age, people with kidney disease, or people who are allergic to ... It is in the category of disease-modifying antirheumatic drugs (DMARDs) family of medications. It is unclear exactly how it ...
Several factors may influence the development of the disease, such as local colonic ischemia, fecal stasis, or mucosal prolapse ... "Diverticular disease associated with inflammatory bowel disease-like colitis: a systematic review". Diseases of the Colon and ... Sladen, GE; Filipe, MI (August 1984). "Is segmental colitis a complication of diverticular disease?". Diseases of the Colon and ... is it the coexistence of colonic diverticulosis and inflammatory bowel disease?". Annals of Gastroenterology. 30 (3): 257-261. ...
Schofield, P. F.; Jones, D. J. (1992). "ABC of colorectal diseases. Colorectal neoplasia-I: Benign colonic tumours". BMJ ( ... Colonic resection may be required for large lesions. These can also lead to secretory diarrhea with large volume liquid stools ...
Bitterness and Colonic Neoplasms". Digestive Diseases and Sciences. 50 (3): 483-9. doi:10.1007/s10620-005-2462-7. PMID 15810630 ...
... a certain level of control is required for effective and safe treatment of colonic diseases. The L. lactis system has a 72-hour ... During clinical trials, it has been used to treat forms of inflammatory bowel disease (IBD). The most prominently studied ... implemented microbial drug delivery with L. lactis in clinical trials, successfully treating Crohn's disease (CD), a form of ... "A Phase I Trial With Transgenic Bacteria Expressing Interleukin-10 in Crohn's Disease". Clinical Gastroenterology and ...
... and total colonic Hirschsprung's disease. An ileostomy may also be necessary in the treatment of colorectal cancer or ovarian ... Diseases of the large intestine which may require surgical removal include Crohn's disease, ulcerative colitis, familial ... In some patients with Crohn's disease, a procedure called an ileoanal anastomosis is done if the disease affects the entire ... 2003), "Surgery for inflammatory bowel diseases", Dig. Dis. 21(2):168-79. doi:10.3748/wjg.14.2678 "Colorectal Diseases and ...
... a greater number than those with inflammatory bowel disease such as Crohn's disease or ulcerative colitis. New agents have been ... is important as many cancer survivors of radiation therapy develop other causes for their symptoms such as colonic polyps, ... Min M, Chua B, Guttner Y, Abraham N, Aherne NJ, Hoffmann M, McKay MJ, Shakespeare TP (2014). "Is "pelvic radiation disease" ... Stacey R, Green JT (2014). "Radiation-induced small bowel disease: latest developments and clinical guidance". Ther Adv Chronic ...
... to a Western diet lower in fiber in rising frequencies of appendicitis as well as the other aforementioned colonic diseases in ... "Pelvic inflammatory disease (PID) Symptoms; Diseases and Conditions". Mayo Clinic. Archived from the original on 2015-05-07. ... Diverticular disease and adenomatous polyps was historically unknown and colon cancer was exceedingly rare in communities where ... "WHO Disease and injury country estimates". World Health Organization. 2009. Archived from the original on 11 November 2020. ...
... cardiovascular diseases, pulmonary diseases, bone diseases, liver diseases, colonic diseases, infections, and HIV. Although ... Dextran prodrugs have potential applications in the treatment of liver diseases, pulmonary diseases, colonic diseases, and ... colonic diseases, bone diseases, and cardiovascular diseases. Dextran micelles are 10 to 100 nm sized amphiphilic polymeric ... Dextran-based drug delivery systems have an enormous potential for clinical use in the treatment of a variety of disease states ...
Scholia has a topic profile for Colonic ulcer. v t e v t e (Abdominal pain, All stub articles, Disease stubs, Digestive system ... Colonic ulcer can occur at any age, in children however they are rare. Most common symptoms are abdominal pain and hematochezia ... Maire, F.; Cellier, C.; Cervoni, J. P.; Danel, C.; Barbier, J. P.; Landi, B. (November 1998). "[Dieulafoy colonic ulcer. A rare ... Large intestine Kleinman, Ronald E. (1998). Atlas of Pediatric Gastrointestinal Disease. PMPH-USA. p. 209. ISBN 978-1-55009-038 ...
... dendritic cell populations in the colonic mucosa of patients with Crohn's disease". European Journal of Immunology. 33 (1): 143 ...
Multinodular disease was representedby nodular colonic lesions and pseudokidney appearances, while the single-nodular Dapaong ... GIDEON Infectious Diseases - Diseases (oesophagostomiasis). GIDEON Infectious Disease Database. 5 Feb 2009. Sun, Tsieh. ... Oesophagostomiasis is generally classified as a zoonotic disease, which is an infectious disease that can be transmitted ... Single-nodular disease, more commonly known as Dapaong disease, is characterized by the development of a single mass that ...
03 is associated with colonic Crohn's disease and ulcerative colitis. DRB1*01:01/*0404 and *01:01/*0401 increases risk of ... In lyme disease arthritis, *01:01 appears to play a role in presentation of triggering microbial antigens. DRB1*01:02 is ... Swiss Federal Commission for the Rheumatic Diseases, Subcommission for Research". Rheumatol Int. 6 (2): 89-92. 1986. doi: ... and disease severity in patients with recurrent respiratory papillomatosis". Hum Immunol. 65 (8): 773-782. doi:10.1016/j.humimm ...
Diverticulosis Hernias Inflammatory bowel disease Colonic volvulus (sigmoid, caecal, transverse colon) Adhesions Constipation ... October 2016). "Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and ... Functional outlet obstruction Inefficient inhibition of the internal anal sphincter Short-segment Hirschsprung's disease Chagas ... Small bowel obstruction caused by Crohn's disease, peritoneal carcinomatosis, sclerosing peritonitis, radiation enteritis, and ...
... of normally indigestible plant polysaccharides and also may result in a reduced incidence of non-infectious colonic diseases. ... whether changes to gut flora are a result of disease, a cause of disease, or both in any number of possible feedback loops in ... Crohn's disease and ulcerative colitis, are chronic inflammatory disorders of the gut; the causes of these diseases are unknown ... which impacts the overall health of the offspring by raising risks of disease such as celiac disease, asthma, and type 1 ...
Breast cancers, thyroid and parathyroid diseases, as well as colonic and rectal cancers are particularly well served by the ... hospital, with its surgeons managing high volumes of these diseases at both Campbelltown public and private hospitals. The ...
Colonic Diseases[majr:noexp] AND humans[mh] AND english[la] AND last 1 Year [edat] NOT (letter[pt] OR case reports[pt] OR ... Biofilms and Benign Colonic Diseases. Songtanin B, Peterson CJ, Molehin AJ, Nugent K. Songtanin B, et al. Int J Mol Sci. 2022 ... Colonic Diseases[majr:noexp] AND humans[mh] AND english[la] AND last 1 Year [edat] NOT (letter[pt] OR case reports[pt] OR ... Endoscopic ultrasound and endoscopic submucosal dissection with a multitraction device for a colonic submucosal lesion. Héroin ...
Health Information on Colonic Diseases: MedlinePlus Multiple Languages Collection ... Colonic Diseases: MedlinePlus Health Topic - English Enfermedades del colon: Tema de salud de MedlinePlus - español (Spanish) ... URL of this page: Other topics A-Z. ...
Crohns disease may mask or mimic the symptoms of colon cancer, complicating diagnosis. Is there a direct association between ... Colonic Adenocarcinoma Revealing Crohns Disease: A Case Report. Amal Ankouz; Karim Ibn Majdoub; Abdelmalek Ousadden; Khalid ... Cite this: Colonic Adenocarcinoma Revealing Crohns Disease: A Case Report - Medscape - May 01, 2010. ... Conclusion: The risk of colonic carcinoma in Crohns disease is increasing. Several case reports actually support the ...
Invasive Colonic Entamoebiasis in Wild Cane Toads, Australia. Emerging Infectious Diseases. 2018;24(8):1541-1543. doi:10.3201/ ... Invasive colonic entamoebiasis in wild cane toads (Rhinella marina), tropical Australia, 2014-2015. A) Toad with severe colonic ... Invasive colonic entamoebiasis in wild cane toads (Rhinella marina), tropical Australia, 2014-2015. A) Toad with severe colonic ... The disease outbreak involved conspicuous behavior, severe clinical disease, and high mortality. Populations of invasive ...
Sounds like majority of disease is in colon. Im confused on "colonic ulceration". I will clear this up at our next appt.. In ... I called the nurse today to ask a few questions about location of disease. She mentioned he has severe colonic ulceration. Is ... I called the nurse today to ask a few questions about location of disease. She mentioned he has severe colonic ulceration. Is ... Sounds like majority of disease is in colon. Im confused on "colonic ulceration". I will clear this up at our next appt. ...
Colonic Diseases. * Barium Enema - हिन्दी (Hindi) Bilingual PDF *Health Information Translations. Colorectal Cancer. * Cancer ...
Overview of colonic volvulus, which occurs when part of the colon twists around its mesentery. The most common types are ... In children, diseases such as Hirschsprung disease or Chagas disease can cause severe swelling of the colon, called megacolon, ... Colonic Volvulus Colonic Volvulus. What is colonic volvulus?. Colonic volvulus occurs when the colon twists around the tissue ... Clinical practice guidelines for colonic volvulus and acute colonic pseudo-obstruction. Diseases of the Colon & Rectum. 2016;59 ...
Colonic involvement in Crohn disease may be right, left sided, or bilateral, whereas in CF, colonic disease is usually right ... Colonic disease. Pickhardt et al performed a retrospective review of 26 patients with CF who underwent abdominal CT, mostly for ... Colonic involvement in CF lacks also other specific findings of Crohn disease such as sinus tracts, fistulas, and abscesses. ... CT findings of meconium ileus include diffuse colonic thickening and no paracolonic changes. The frequency of Crohn disease has ...
Invasive Colonic Entamoebiasis in Wild Cane Toads, Australia. Emerging Infectious Diseases. 2018;24(8):1541-1543. doi:10.3201/ ... Invasive colonic entamoebiasis in wild cane toads (Rhinella marina), tropical Australia, 2014-2015. A) Toad with severe colonic ... Invasive colonic entamoebiasis in wild cane toads (Rhinella marina), tropical Australia, 2014-2015. A) Toad with severe colonic ... The disease outbreak involved conspicuous behavior, severe clinical disease, and high mortality. Populations of invasive ...
Colonic anisakiasis: an exceptional presentation Infectious Diseases & Tropical Medicine 2020; 6: e615 DOI: 10.32113/idtm_20206 ... Infectious Diseases & Tropical Medicine 2020; 6: e615 DOI: 10.32113/idtm_20206_615 Topic: Parasitic diseases Category: Case ... Anisakiasis is a worldwide parasitic disease with 90% of reported cases in Japan. Here we present the case of a Spanish 55 ... 2016 Infectious Diseases & Tropical Medicine - Privacy Policy. Publisher: Verduci International (branch office of Verduci ...
Rectal Diseases. Anus Diseases. Colonic Diseases 3. Diseases of the rectum, anus, and colon: including the ileocolic angle, ... Rectal Diseases. Anus Diseases. Colonic Diseases 4. Diseases of the rectum, anus, and colon: including the ileocolic angle, ... Rectal Diseases. Anus Diseases. Colonic Diseases 5. Diseases of the rectum, anus, and colon: including the ileocolic angle, ... Start Over You searched for: Subjects Colonic Diseases ✖Remove constraint Subjects: Colonic Diseases ...
Colonic Diseases. * Barium Enema - हिन्दी (Hindi) Bilingual PDF *Health Information Translations. Colorectal Cancer. * Cancer ...
Colonic Diverticulosis - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the MSD Manuals - Medical ... Complications of colonic diverticular disease are more common among people who smoke, are obese, have HIV infection, or use ... 1. Elisei W, Tursi A: Recent advances in the treatment of colonic diverticular disease and prevention of acute diverticulitis. ... Etiology of Colonic Diverticulosis The etiology of colonic diverticulosis is multifactorial and not entirely known. Several ...
Timothy R. Koch (2003). Colonic diseases. Humana Press. pp. 387-. ISBN 978-0-89603-961-2. Retrieved 2010-11-12.[permanent dead ... "Hirschsprungs disease". Genetic and Rare Diseases Information Center (GARD) - an NCATS Program. 2017. Archived from the ... "Hirschsprungs disease". Mayo Clinic. Retrieved 30 January 2023. Heuckeroth RO (March 2018). "Hirschsprung disease - ... "Definition & Facts for Hirschsprung Disease - NIDDK". National Institute of Diabetes and Digestive and Kidney Diseases. ...
Post-operative colonic manometry in children with Hirschsprung disease : A systematic review. / Evans-Barns, Hannah M. E.; ... Post-operative colonic manometry in children with Hirschsprung disease: A systematic review. Neurogastroenterology and Motility ... Post-operative colonic manometry in children with Hirschsprung disease : A systematic review. In: Neurogastroenterology and ... title = "Post-operative colonic manometry in children with Hirschsprung disease: A systematic review", ...
CoDIR - Colonic disease investigation by robotic hydro-colonoscopy. *Start date: 1 January 2010 ... Our work centres on understanding the complex geometry and mechanical nature of the colonic system (through mechanical ...
Colonic Ischemia How to Cite This Chapter: Yoon HM, McKechnie T, Eskicioglu C, Bartnik W. Colonic Ischemia. McMaster Textbook ... 1) Medical conditions: Cardiovascular disease (eg, atherosclerosis, peripheral vascular disease, congestive heart failure, ... and colonic inflammation. Ischemic colitis is the most frequent and less severe form of colonic ischemia. Segments of the ... Increased mortality rates occur in patients with chronic kidney disease or chronic obstructive pulmonary disease, in those ...
... scale consisting of 15 items for assessment of gastrointestinal symptoms in irritable bowel syndrome and peptic ulcer disease ... Colonic Diseases, Functional / complications * Colonic Diseases, Functional / physiopathology* * Diagnosis-Related Groups* * ... GSRS--a clinical rating scale for gastrointestinal symptoms in patients with irritable bowel syndrome and peptic ulcer disease ... scale consisting of 15 items for assessment of gastrointestinal symptoms in irritable bowel syndrome and peptic ulcer disease ...
T1 - Colonic Adventitial Fibromuscular Dysplasia. T2 - A Nonspecific Arteriopathy Associated With Hirschsprung Disease and ... Colonic Adventitial Fibromuscular Dysplasia: A Nonspecific Arteriopathy Associated With Hirschsprung Disease and Other ... title = "Colonic Adventitial Fibromuscular Dysplasia: A Nonspecific Arteriopathy Associated With Hirschsprung Disease and Other ... Colonic Adventitial Fibromuscular Dysplasia: A Nonspecific Arteriopathy Associated With Hirschsprung Disease and Other ...
Colonic Motility: From Bench S…le to Function to Disease #11) - down 3.28% ($1.14) to $33.63 from $34.77. by ...
The value of CA125 in predicting acute complicated colonic diverticulitis (International journal of colorectal disease (2023) ... The value of CA125 in predicting acute complicated colonic diverticulitis (International journal of colorectal disease (2023) ... International journal of colorectal disease (2023) 38 1 (182)). International Journal of Colorectal Disease. 2023 Aug 9;38(1): ... International journal of colorectal disease (2023) 38 1 (182)). In: International Journal of Colorectal Disease. 2023 ; Vol. 38 ...
99m Tc-Sucralfate scintigraphy and colonic disease Br Med J (Clin Res Ed) 1987; 295 :1134 (Published 31 October 1987) ... 99m Tc-Sucralfate scintigraphy and colonic disease Br Med J (Clin Res Ed) 1987; 295 :1135 (Published 31 October 1987) ... 99m Tc-Sucralfate scintigraphy and colonic disease Br Med J (Clin Res Ed) 1987; 295 :1135 (Published 31 October 1987) ... 99m Tc-Sucralfate scintigraphy and colonic disease Br Med J (Clin Res Ed) 1987; 295 :1135 (Published 31 October 1987) ...
Colonic Diseases / pathology* * Enterochromaffin Cells* * Histocytochemistry * Humans * Intestinal Mucosa / innervation* * ...
Colonic Diseases. Humana Press Human Press, Totowa NJ: 211-222. Cuff CF, Fulton JR, Barnett JB, and Boyce CS (1998). Enteric ... 2003). Immunology of the Gastrointestinal Tract Colonic Diseases. Humana Press Human Press, Totowa NJ: 105-122 ...
Colonic Diseases (1) Colonoscopy (1) Congenital Heart Defects (1) Cáncer (1) Depression (1) ... Supplemental Project To Assess the Transparency of Reporting Requirements: Omega-3 Fatty Acids and Cardiovascular Disease ...
Colonic Diseases (1) Colonoscopy (1) Congenital Heart Defects (1) Critical Care (2) ... Comparative Effectiveness of Intravenous Iron Formulations in the Treatment of Anemia in End Stage Renal Disease ... Supplemental Project To Assess the Transparency of Reporting Requirements: Omega-3 Fatty Acids and Cardiovascular Disease ... or Risk Factors of Chronic Diseases: Pilot Study of New Checklists ...
Colonic vasoactive intestinal peptide nerves in inflammatory bowel disease.﻽. Kubota Y, Petras RE, Ottaway CA, Tubbs RR, Farmer ... Inflammatory Bowel Disease. (1990) Chapter: Natural history and prognosis of large intestine Crohn s disease. In: Second ... Inflammatory bowel disease and leukemia. A report of seven cases of leukemia in ulcerative colitis and Crohns disease and ... Recurrence and reoperation for Crohns disease: the role of disease location in prognosis.﻽. Lock MR, Farmer RG, Fazio VW, ...
... which may contribute to fibrostenotic Crohns disease. In this review, we will discuss the pathophysiological significance of ... which may contribute to fibrostenotic Crohns disease. In this review, we will discuss the pathophysiological significance of ... Sarna, S. K., and Shi, X.-Z. (2006). "Function and Regulation of Colonic Contractions in Health and Disease," in Physiology of ... Levine, A., and Wine, E. (2013). Effects of Enteral Nutrition on Crohns Disease: Clues to the Impact of Diet on Disease ...
  • Colonic diverticular disease (diverticulosis) is a common disorder in Western countries. (
  • Interstitial cells of Cajal and glial cells are decreased in colonic diverticular disease, whereas enteric neurones appear to be normally represented. (
  • Definition of Diverticular Disease Diverticula are saclike mucosal pouches that protrude from a tubular structure. (
  • Several studies have suggested a correlation between symptomatic diverticular disease and environmental factors such as a diet low in fiber or high in red meat, sedentary lifestyle, obesity, smoking, and use of nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin , acetaminophen , corticosteroids, and opioids. (
  • Alterations in enteric calcitonin gene-related peptide in patients with colonic diverticular disease: CGRP in diverticular disease. (
  • Colonic diverticular disease has been increasing in prevalence in Japan due to the rapidly aging population. (
  • Colonic diverticular bleeding can result in hemorrhagic shock requiring blood transfusion, and it carries a high risk of recurrence within 1 year. (
  • Stimulation of colonic motility by oral PEG electrolyte bowel preparation assessed by MRI: comparison of split vs single dose. (
  • Inflammatory Bowel Disease (IBD) primarily consists of two main ailments: Ulcerative Colitis (UC) and Crohn's Disease (CD). (
  • Oral delivery of nucleic acid drugs to the colon would be highly desirable to provide new options for the treatment of serious and rare colonic diseases such as ulcerative colitis, Crohn's colitis, and Lynch syndrome, but has been challenging due to the harsh conditions found in the gastrointestinal tract and low cellular uptake. (
  • Inflammatory bowel disease, including ulcerative colitis and Crohn disease. (
  • It starts to get a bit tricky to find your way around diagnosing Crohn's disease and ulcerative colitis because you have to look at so many guidelines," said Christian Maaser, MD, from Hospital Lüneburg in Germany. (
  • Colonoscopy is the technique of choice to assess disease activity in patients with symptomatic colonic Crohn's disease or ulcerative colitis. (
  • There are a number of clinical scoring systems for Crohn's disease and ulcerative colitis, each with its own pros and cons, Maaser explained. (
  • Presentations resembling inflammatory bowel disease, specifically ulcerative colitis, are rare. (
  • IBD is comprised of two conditions: ulcerative colitis and Crohn's disease. (
  • Panniculitis is an aggravation of the fatty layer underneath the skin which occurs due to Crohn's disease (inflammation of the digestive system) or ulcerative colitis (inflammation of the colon and rectum). (
  • Pyostomatitis vegetans can be a symptom of Crohn's disease and ulcerative colitis. (
  • It most commonly affects women and is caused by Crohn's disease and ulcerative colitis. (
  • This skin symptom can be the result of ulcerative colitis or Crohn's disease. (
  • Inflammatory bowel disease, comprised of ulcerative colitis (UC) and Crohn's disease (CD), affects tens of thousands of patients in Ireland alone. (
  • The work published in March studied paired biopsies from inflamed and non-inflamed mucosa of 80 adult patients with ulcerative colitis and 50 with Crohn's disease, along with paired biopsies of 31 non-IBD controls, all recruited in Ireland. (
  • Panel C), Crohn' disease behavior (Panel D) and ulcerative colitis disease extent (Panel E), Related to Table 1. (
  • Effect of IBD treatment exposures on serum CRP and Fecal calprotectin in Crohn's disease (Panel A) and ulcerative colitis (Panel B), Related to Figure 4. (
  • This conjugate will be designed to be stable in the upper gastrointestinal tract and deliver locally the nucleic acid drug to the colonic mucosa. (
  • The aim of this project is to design a nucleic acid prodrug that is stable in the upper gastrointestinal tract, activated in the colon, and internalized in the colonic mucosa. (
  • By selecting a locally accessible target (colonic mucosa) and exploiting the particular enzymatic environment of the colonic lumen, a clinically viable delivery system for orally-administered AONs could be realistically developed. (
  • Relative expression of miR-16 ( a ), miR-21 ( b ), miR-122 ( c ), miR-146a ( d ), miR-147 ( e ), miR-185 ( f ), miR-192 ( g ) and miR-223 ( h ) in the colonic mucosa of healthy dogs (Controls) ( n = 9) and dogs with large intestinal inflammatory bowel disease (IBD) ( n = 26). (
  • A drug commonly used to treat hyperkalemia has the potential to damage the GI mucosa, especially in surgical patients or patients with end-stage renal disease. (
  • When the results were combined with known transcription data from human tissue, the scientists noticed that the location of certain intestinal cells was the same in both mice and humans, which makes the model a tool for understanding how different diseases, such as IBD, affect the colon. (
  • Gross pathologic findings ranged from no obvious lesions in mildly affected toads to thickened colonic walls with hyperemic serosal vasculature and hemorrhagic content in severely affected toads ( Figure 1 , panel A). Histologically appreciable lesions (invasive amebiasis) were commonly limited to the colon, although in severely affected toads, lesions extended through the small intestine and, rarely, into the stomach. (
  • But the pattern of disease in the colon shows up more like Crohn's. (
  • Sounds like majority of disease is in colon. (
  • They are similar diseases, but as its name suggests, UC is confined to the colon (and rectum). (
  • The developed colon specific cleavable PEGylation could be widely applied for the delivery of therapeutic oligonucleotides targeting rare colonic diseases. (
  • Apart from one patient with an early colonic stricture, none of those exposed to high doses of lipase, or the methacrylic acid copolymer Eudragit L30 D55, showed evidence of subclinical damage to the colon. (
  • Long-term opiate narcotic use (including diphenoxylate and loperamide) may lead to colonic dilatation and may limit the ability of the colon to contract when dilated. (
  • Colon resections (colectomies) are performed to treat and prevent diseases and conditions that affect the colon, such as colon cancer (see the image below). (
  • Colonic polyps are important because, over time, some of them may transform into a colon cancer. (
  • Diseases of the colon and rectum. (
  • Many clinicians recommend that the drug be used in patients with left-sided disease, restricted to the colon. (
  • There is some evidence that concomitant therapy with sulfasalazine and corticosteroids may not be more effective than either drug alone, but some subgroups of patients may have a better response to combined therapy (e.g., those with disease localized in the colon). (
  • Colonic diverticulosis is the presence of one or more diverticula in the colon. (
  • Procesos patológicos en la región del COLON del INTESTINO GRUESO. (
  • Thanks to a Wellcome Trust VIP Fellowship and a RCUK Academic Fellowship I then moved to the School of Medicine, where I am now Professor in Gastrointestinal Imaging at the Nottingham Digestive Diseases Centre (NDDC) within the Translational Medical Sciences academic unit. (
  • May be useful in patients with mild to moderately active disease, especially those with ileocolonic or colonic involvement. (
  • SUBJECTS: A total of 59 patients with ileocolonic, ileocaecal or colonic Crohn's disease. (
  • Magnetic resonance enterography is increasingly utilized for assessment of luminal Crohn's disease activity. (
  • Upper gastrointestinal endoscopy is still recommended for people with Crohn's disease and upper GI symptoms. (
  • When monitoring Crohn's disease, the guidelines state that clinical and biochemical responses to treatment should be determined in the 12-week period after the initiation of therapy. (
  • For the diagnosis of perianal Crohn's disease, clinical and endoscopic examination of the rectum plus MRI should be used. (
  • Management of active Crohn's disease † [off-label] . (
  • OBJECTIVES: To ascertain whether patients with Crohn's disease treated with azathioprine maintained bone mineral mass better than patients treated with steroids alone. (
  • However, by being steroid-saving, it seems to conserve bone mineral mass in patients with Crohn's disease. (
  • on the Simple Endoscopic Score for Crohn's Disease (SES-CD), the mean lower gastrointestinal score fell from 13 to 4 in the treatment group but remained unchanged in the control group. (
  • The treatment group also showed a greater decrease than the control group in median Crohn's Disease Activity Index score (approximately 165 vs 50 points). (
  • Bile acids Bile acid turnover By-pass operation Crohn s disease Elimination Faecal excretion Faeces Ileal resection Abstract. (
  • Treatment of Crohn disease has changed over the past few years, reflecting new therapies that can target specific locations in the gastrointestinal (GI) tract and specific cytokines. (
  • The development of biologic anti-tumor necrosis factor (anti-TNF) agents (eg, infliximab, adalimumab, certolizumab pegol, and natalizumab) has significantly advanced the treatment of Crohn disease and improved the induction and maintenance of clinical remission in patients with moderate to severe disease, especially in those who are corticosteroid dependent. (
  • If medical therapy for active Crohn disease fails, surgical resection of the inflamed bowel, with restoration of continuity, is indicated. (
  • In 2013, the first randomized controlled trial of stem cell transplantation in treatment-resistant Crohn disease was performed in 45 patients with moderately to severely active disease. (
  • Many patients with an exacerbation of Crohn disease can be treated on an outpatient basis. (
  • Therapy for mild Crohn disease is typically administered in a sequential "step-up" approach, in which less aggressive and less toxic treatments are initiated first, followed by more potent medications or procedures if the initial therapy fails. (
  • Crohn disease is an idiopathic disorder that can involve the entire GI tract with transmural inflammation, noncaseating granulomas, and fissures. (
  • Symptoms of Crohn disease include intermittent attacks of diarrhea, constipation, abdominal pain, and fever. (
  • Intraoral involvement in Crohn disease occurs in 8-29% of patients and may precede intestinal involvement. (
  • [ 9 ] Extraintestinal features are also common in persons with Crohn disease, and these may manifest systemically as arthritis, clubbing of the fingers, sacroiliitis, and erythema nodosum. (
  • Noncaseating granulomas are characteristic of orofacial Crohn disease. (
  • Whether patients with orofacial granulomatoses will subsequently develop intestinal manifestations of Crohn disease is uncertain, but histologic similarities between the oral lesions and the intestinal lesions are obvious. (
  • Acute and chronic inflammation, with lymphocytic and giant cell perivascular infiltrates, and lymphoid follicles are the most common histologic findings in oral and GI Crohn disease. (
  • Oral findings as described above warrant a full systemic evaluation for intestinal Crohn disease, including referral for colonoscopy and biopsy with histopathologic correlation. (
  • This may progress to colonic perforation, causing life-threatening sepsis. (
  • Early diagnosis and management avoids the potential complications of patients with Hirschsprung's disease. (
  • Patients with the diagnosis of Hirschsprung's disease were included during the established term, who had undergone surgery. (
  • RITM undertakes research activities in the diagnosis, control and prevention of tropical diseases that are major causes of mortality and morbidity in the Philippines, develops cost-effective strategie. (
  • Oral manifestations can prove crucial in diagnosis and usually parallel the intestinal disease course. (
  • A total of 83(46.9%) of the patients had appendicitis related diagnosis, 16(9.0%) of the cases resulted from trauma, 25(14.1%) had intestinal obstruction from post-operative bands, 28(15.8%) had intestinal obstruction from colonic tumours and 17(9.6%) had perforated peptic ulcer disease. (
  • IBD: Inflammatory bowel diseases. (
  • We may be able to predict disease relapse in patients with chronic inflammatory bowel diseases based on their microbiome markers, according researchers from APC Microbiome Ireland. (
  • In parallel, this research allowed the identification of other local nucleic acid delivery strategies for the treatment of intestinal diseases. (
  • Objectives The hypothesis of the study was that if the gut microbiota is involved in the development of atherosclerotic cardiovascular and cerebrovascular diseases (CVDs), total colectomy may reduce the long-term risk of CVDs. (
  • The most recent study, published in the journal Gut ​yesterday (June 14th), followed 700 Irish and Canadian patients with CD and UC and ranked the effect of disease activity, medications, diet and geographic location on their faecal microbiota composition at three time points with 16 weeks intervals and revealed disturbances in the microbiome associated with relapses of disease. (
  • Epithelial DNA methylation improves disease classification and is associated with both inflammation and microbiota composition. (
  • In conclusion, inflamed and non-inflamed colonic segments in both CD and UC differ in microbiota composition and epigenetic profiles. (
  • Effects of Resistant Starch on Symptoms, Fecal Markers and Gut Microbiota in Parkinson's Disease - the RESISTA-PD Trial. (
  • Gut microbiota are related to Parkinson's disease and clinical phenotype. (
  • Functional analyses of RET mutations in Chinese Hirschsprung disease patients. (
  • Its main characteristic is that a section of the bowel is unable to relax, causing functional colonic obstruction. (
  • Functional implications of microbial and viral gut metagenome changes in early stage L-DOPA-naïve Parkinson's disease patients. (
  • Despite significant constipation and abdominal distention, children with Hirschsprung disease rarely develop encopresis (fecal incontinence secondary to impacted stools). (
  • Less commonly, patients may present with fecal occult blood, or massive colonic and gastric hemorrhage. (
  • Se reporta dos casos de retroneumoperitoneo con neumo-mediastino, consecuencias de perforaciones diverticulares en el espacio retroperitoneal, en pacientes portadores de diverticulitis aguda y septicemia. (
  • Colonic diverticulitis can cause abscess, fistula. (
  • The Gastroenterology section of the Medscape Drugs & Diseases journal contains three articles devoted to megacolon, and they are separated based on the three aforementioned categories (see also Differentials ). (
  • She mentioned he has severe colonic ulceration. (
  • In the meantime, does anyone have any experience with their child having Colonic ulceration? (
  • Primary and secondary outcome measures The primary outcome was the first occurring CVD event in any of the seven diagnostic domains (hypertensive disorders, acute ischaemic heart diseases, chronic ischaemic heart disease, cardiac arrhythmias, heart failure, cerebrovascular diseases and other arterial diseases) and the secondary outcomes were the first occurring event within each of these domains. (
  • Acute colonic pseudoobstruction (ACPO) is a rare condition first reported in 1948 by Sir William Ogilvie. (
  • It is characterized by acute colonic dilatation in the absence of an intrinsic mechanical obstruction or an extrinsic inflammatory process (toxic megacolon). (
  • The pathophysiology underlying acute colonic pseudoobstruction (ACPO) (acute megacolon, Ogilvie syndrome) remains unresolved. (
  • Enterocolitis, an acute complication of Hirschsprung disease, is characterised by sudden onset of fever, abdominal distension, vomiting, passage of bloody stools or release of explosive gas or stools after rectal examination. (
  • An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (
  • Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (
  • Initial therapy of acute graft-versus-host disease with low-dose prednisone does not compromise patient outcomes. (
  • Oral beclomethasone dipropionate for the treatment of gastrointestinal acute graft-versus-host disease (GVHD). (
  • 5. Acute or chronic decompensated lung diseases. (
  • The stool faecal occult, faecal immunochemical test (FIT) is used as part of screening at-risk individuals for colonic polyps and colorectal cancer. (
  • Dr. Temple has expertise in the management of colorectal diseases, and in particular, colorectal malignancies. (
  • Typically, Hirschsprung disease is diagnosed shortly after birth, although it may develop well into adulthood, because of the presence of megacolon, or because the baby fails to pass the first stool (meconium) within 48 hours of delivery. (
  • Those who pass stools after 36 to 48 hours after birth should raise suspicion of Hirschsprung disease. (
  • Hirschsprung disease should be considered in any newborn with delayed passage of meconium or in any child with a history of chronic constipation since birth. (
  • Older children with Hirschsprung disease usually have chronic constipation since birth. (
  • A low imperforate anus with a perineal orifice may have a similar presentation to that of a patient with Hirschsprung disease. (
  • Trans-ethnic meta-analysis of genome-wide association studies for Hirschsprung disease. (
  • RET mutational spectrum in Hirschsprung disease: evaluation of 601 Chinese patients. (
  • Hirschsprung´s disease (congenital megacolon ) is a common cause of lower bowel obstruction in neonates. (
  • This prodrug should constitute a versatile vehicle to explore new therapeutic targets and design more effective drugs in rare bowel diseases. (
  • Prenatal ultrasonography demonstrating bowel obstruction is rare, except in cases of total colonic involvement. (
  • Liverani E, Scaioli E, Digby RJ, Bellanova M, Belluzzi A. How to predict clinical relapse in inflammatory bowel disease patients. (
  • the clinical and epidemiological characteristics of the cases of Hirschsprung's Disease analyzed are similar to those reported in the literature. (
  • Chronic strongyloidiasis is generally asymptomatic, but in patients with clinical disease gastrointestinal and cutaneous manifestations are the most common. (
  • It is therefore critically important to define the microbiome of healthy persons in order to detect significant variations both in disease states and in pre-clinical conditions to understand disease onset and progression. (
  • A) Toad with severe colonic amebiasis. (
  • If no response occurs or if the disease is more severe than initially thought, corticosteroids and inhibitors of DNA synthesis (ie, immunomodulators) with 6-mercaptopurine (6-MP)/azathioprine or methotrexate are administered. (
  • These data provide a critical baseline for future studies investigating local and systemic diseases affecting human health. (
  • 32% (138/432) were related to surgical pathologies and the remaining 31.9% (136/432) were related to systemic diseases. (
  • Dr. Geibel's areas of research interests include gastric acid secretion, colonic fluid transport, renal physiology and diarrheal disease. (
  • Heanue TA, Pachnis V. Enteric nervous system development and Hirschsprung's disease: advances in genetic and stem cell studies. (
  • 1994. Pancreatitis in patients with end-stage renal disease. (
  • Anorectal and Colonic Diseases: A Practical Guide to Their by Felix Aigner, Helga Fritsch (auth. (
  • the great, but easy-to-read, details during this useful advisor on either universal and infrequent anorectal and colonic ailments is very vital for either the practitioner, who must recognize all of the attainable modalities of conservative and surgical procedure, and the health practitioner, who must adapt his surgery to the medical and anatomical findings. (
  • Magnetic Resonance Imaging Quantification of Fasted State Colonic Liquid Pockets in Healthy Humans. (
  • To understand the relationship between our bacterial microbiome and health, it is essential to define the microbiome in the absence of disease. (
  • The bacterial microbiome of the human digestive tract contributes to both health and disease. (
  • Colonic bacterial composition in Parkinson's disease. (
  • Fissures or fistulas may occur in persons with chronic disease. (
  • Full thickness colonic samples were obtained from 39 patients undergoing surgery for diverticulosis. (
  • Increased colonic wall thickness has been reported in patients exposed to large doses of high strength pancreatic enzyme preparations who did not develop fibrosing colonopathy. (
  • The relation between sonographically measured colonic wall thickness and pancreatic enzyme preparation and dose was studied in 86 children with cystic fibrosis (CF). Colonic wall thickness of a control group was also measured. (
  • The average thickness in all colonic regions was higher in the CF group (overall average range 0.7-2.5 mm v 0.6-1.4 mm in the control group). (
  • There was no significant relation between colonic wall thickness and age, sex, total dose of lipase, or copolymer. (
  • VIENNA - New guidelines designed to streamline recommendations on inflammatory bowel disease (IBD) have been developed by the European Crohn's and Colitis Organisation (ECCO) and the European Society of Gastrointestinal and Abdominal Radiology (ESGAR). (
  • Eighty six CF patients and 12 controls underwent colonic sonography. (
  • The major strength of the study is based on the availability of information in the entire Danish Patient Register from 1996 to 2014, which allows historical prospective assessment of the risk of new occurrences of cardiovascular and cerebrovascular diseases (CVDs) during long-term, essentially complete follow-up in patients after colectomy by comparison with matched patients that had undergone other types of surgery. (
  • Nucleic acids, such as antisense oligonucleotides (AONs) and small interfering RNAs (siRNAs) have enormous potential as therapeutics for life-threatening diseases because in principle, any problematic gene can be targeted with high efficacy and sequence-specificity. (
  • [ 8 ] However, oral manifestations at follow-up once disease is controlled may not be a marker for recurring intestinal disease. (
  • Do more mature preterm babies with surgical necrotizing enterocolitis predominantly develop the colonic disease? (
  • 5-9 Disease management has evolved over the years from very invasive procedures performed in several stages including three surgeries, to minimally invasive procedures carried out in a single surgical intervention. (
  • We detected a disease syndrome in free-ranging Australian cane toads involving atypical behavior and emaciation that is associated with a previously undescribed Entamoeba sp. (
  • Hirschsprung's disease (HD or HSCR) is a birth defect in which nerves are missing from parts of the intestine. (
  • Treatment for this disease requires the resection of the abnormal bowel segment in order to restore the functions of the healthy part of the intestine. (
  • Hirschsprung's disease is a congenital disorder characterized by the absence of ganglion cells in the myenteric and submucosal plexuses of the intestine. (
  • Okamoto E, Takashi U. Embryogenesis of intramural ganglia of the gut and its relation to Hirschsprung's disease. (
  • May not be effective in patients with small bowel disease. (
  • Bearded Collies can suffer from health concerns including hip dysplasia, hypothyroidism, epilepsy or colonic disease. (
  • Dr Marcus Claesson, leader of this research at APC Microbiome Ireland, said the studies will open the way for doctors to be able to predict relapses of disease before patients develop symptoms. (
  • More importantly, it will allow establishing a technological platform, which could be exploited for the oral treatment of several rare colonic diseases. (
  • Children who do not respond to constipation treatment for six months should also raise suspicion of such disease. (
  • Oral beclomethasone dipropionate for treatment of human intestinal graft-versus-host disease. (
  • 1992. A Multicenter, double-blind, randomized, placebo-controlled, comparison of nocturnal Roxatidine in the treatment of active duodenal ulcer disease. (
  • Hyperinfection syndrome and disseminated strongyloidiasis are most frequently associated with subclinical infection in patients receiving high-dose corticosteroids for the treatment of asthma or chronic obstructive pulmonary disease (COPD) exacerbations. (
  • Genera with pathogenic members were well-represented among this disease-free cohort. (