Tumors or cancer of the COLON.
The segment of LARGE INTESTINE between TRANSVERSE COLON and the SIGMOID COLON.
A segment of the COLON between the RECTUM and the descending colon.
The segment of LARGE INTESTINE between the CECUM and the TRANSVERSE COLON. It passes cephalad from the cecum to the caudal surface of the right lobe of the LIVER where it bends sharply to the left, forming the right colic flexure.
The segment of LARGE INTESTINE between ASCENDING COLON and DESCENDING COLON. It passes from the RIGHT COLIC FLEXURE across the ABDOMEN, then turns sharply at the left colonic flexure into the descending colon.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells such as the GOBLET CELLS.
A potent carcinogen and neurotoxic compound. It is particularly effective in inducing colon carcinomas.
A pouch or sac opening from the COLON.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).
A malignant epithelial tumor with a glandular organization.
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
A DNA alkylating agent that has been shown to be a potent carcinogen and is widely used to induce colon tumors in experimental animals.
Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
A cell line derived from cultured tumor cells.
Hydrazines substituted with two methyl groups in any position.
Excision of a portion of the colon or of the whole colon. (Dorland, 28th ed)
Endoscopic examination, therapy or surgery of the luminal surface of the colon.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A benign epithelial tumor with a glandular organization.
Human colonic ADENOCARCINOMA cells that are able to express differentiation features characteristic of mature intestinal cells, such as ENTEROCYTES. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation.
Tumors or cancer of the SIGMOID COLON.
Tumors or cancer of the RECTUM.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
The motor activity of the GASTROINTESTINAL TRACT.
The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.
Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Pathological processes that tend eventually to become malignant. (From Dorland, 27th ed)
Derivatives of BUTYRIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxypropane structure.
Agents that reduce the frequency or rate of spontaneous or induced tumors independently of the mechanism involved.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Discrete abnormal tissue masses that protrude into the lumen of the INTESTINE. A polyp is attached to the intestinal wall either by a stalk, pedunculus, or by a broad base.
Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.
A segment of the LOWER GASTROINTESTINAL TRACT that includes the CECUM; the COLON; and the RECTUM.
A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
The surgical construction of an opening between the colon and the surface of the body.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Tumor suppressor genes located in the 5q21 region on the long arm of human chromosome 5. The mutation of these genes is associated with familial adenomatous polyposis (ADENOMATOUS POLYPOSIS COLI) and GARDNER SYNDROME, as well as some sporadic colorectal cancers.
Tumors or cancer of the CECUM.
Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.
Pathological processes in the SIGMOID COLON region of the large intestine (INTESTINE, LARGE).
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
A solution or compound that is introduced into the RECTUM with the purpose of cleansing the COLON or for diagnostic procedures.
High molecular weight mucoproteins that protect the surface of EPITHELIAL CELLS by providing a barrier to particulate matter and microorganisms. Membrane-anchored mucins may have additional roles concerned with protein interactions at the cell surface.
The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
A reagent that is used to neutralize peptide terminal amino groups.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Agents that are used to stimulate evacuation of the bowels.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.
A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Transplantation between animals of different species.
Tumors or cancer of the INTESTINES.
An inducibly-expressed subtype of prostaglandin-endoperoxide synthase. It plays an important role in many cellular processes and INFLAMMATION. It is the target of COX2 INHIBITORS.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
The relationship between the dose of an administered drug and the response of the organism to the drug.
The occurrence of highly polymorphic mono- and dinucleotide MICROSATELLITE REPEATS in somatic cells. It is a form of genome instability associated with defects in DNA MISMATCH REPAIR.
Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.
A negative regulator of beta-catenin signaling which is mutant in ADENOMATOUS POLYPOSIS COLI and GARDNER SYNDROME.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Inflammation of the COLONIC DIVERTICULA, generally with abscess formation and subsequent perforation.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Regular course of eating and drinking adopted by a person or animal.
A compound used as an x-ray contrast medium that occurs in nature as the mineral barite. It is also used in various manufacturing applications and mixed into heavy concrete to serve as a radiation shield.
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
Elements of limited time intervals, contributing to particular results or situations.
The remnants of plant cell walls that are resistant to digestion by the alimentary enzymes of man. It comprises various polysaccharides and lignins.
A sulfinylindene derivative prodrug whose sulfinyl moiety is converted in vivo to an active NSAID analgesic. Specifically, the prodrug is converted by liver enzymes to a sulfide which is excreted in the bile and then reabsorbed from the intestine. This helps to maintain constant blood levels with reduced gastrointestinal side effects.
Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Hydrazines substituted by one or more methyl groups in any position.
Methods of investigating the effectiveness of anticancer cytotoxic drugs and biologic inhibitors. These include in vitro cell-kill models and cytostatic dye exclusion tests as well as in vivo measurement of tumor growth parameters in laboratory animals.
Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Benign neoplasms derived from glandular epithelium. (From Stedman, 25th ed)
A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.
Opening or penetration through the wall of the INTESTINES.
A plastic operation on the esophagus. (Dorland, 28th ed)
Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms.
A group of organs stretching from the MOUTH to the ANUS, serving to breakdown foods, assimilate nutrients, and eliminate waste. In humans, the digestive system includes the GASTROINTESTINAL TRACT and the accessory glands (LIVER; BILIARY TRACT; PANCREAS).
Dilatation of the COLON, often to alarming dimensions. There are various types of megacolon including congenital megacolon in HIRSCHSPRUNG DISEASE, idiopathic megacolon in CONSTIPATION, and TOXIC MEGACOLON.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
One of two ganglionated neural networks which together form the ENTERIC NERVOUS SYSTEM. The myenteric (Auerbach's) plexus is located between the longitudinal and circular muscle layers of the gut. Its neurons project to the circular muscle, to other myenteric ganglia, to submucosal ganglia, or directly to the epithelium, and play an important role in regulating and patterning gut motility. (From FASEB J 1989;3:127-38)
DNA present in neoplastic tissue.
In vivo methods of screening investigative anticancer drugs, biologic response modifiers or radiotherapies. Human tumor tissue or cells are transplanted into mice or rats followed by tumor treatment regimens. A variety of outcomes are monitored to assess antitumor effectiveness.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Tumors or cancer of the LIVER.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Uptake of substances through the lining of the INTESTINES.
Enzyme complexes that catalyze the formation of PROSTAGLANDINS from the appropriate unsaturated FATTY ACIDS, molecular OXYGEN, and a reduced acceptor.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Endoscopic examination, therapy or surgery of the sigmoid flexure.
The contents included in all or any segment of the GASTROINTESTINAL TRACT.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Short-chain fatty acids of up to six carbon atoms in length. They are the major end products of microbial fermentation in the ruminant digestive tract and have also been implicated in the causation of neurological diseases in humans.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.
A bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorption, is reabsorbed itself, and is used as a choleretic and detergent.
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
Inflammation of the COLON due to colonic ISCHEMIA resulting from alterations in systemic circulation or local vasculature.
Generally refers to the digestive structures stretching from the MOUTH to ANUS, but does not include the accessory glandular organs (LIVER; BILIARY TRACT; PANCREAS).
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Antibodies produced by a single clone of cells.
The middle portion of the SMALL INTESTINE, between DUODENUM and ILEUM. It represents about 2/5 of the remaining portion of the small intestine below duodenum.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Established cell cultures that have the potential to propagate indefinitely.
An antihelminthic drug that has been tried experimentally in rheumatic disorders where it apparently restores the immune response by increasing macrophage chemotaxis and T-lymphocyte function. Paradoxically, this immune enhancement appears to be beneficial in rheumatoid arthritis where dermatitis, leukopenia, and thrombocytopenia, and nausea and vomiting have been reported as side effects. (From Smith and Reynard, Textbook of Pharmacology, 1991, p435-6)
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Antimetabolites that are useful in cancer chemotherapy.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA TOPOISOMERASES, TYPE I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity.
Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein.
The normal process of elimination of fecal material from the RECTUM.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
Specially designed endoscopes for visualizing the interior surface of the colon.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
RNA present in neoplastic tissue.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
Organic compounds which contain platinum as an integral part of the molecule.
An adenoma of the large intestine. It is usually a solitary, sessile, often large, tumor of colonic mucosa composed of mucinous epithelium covering delicate vascular projections. Hypersecretion and malignant changes occur frequently. (Stedman, 25th ed)
A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A movement, caused by sequential muscle contraction, that pushes the contents of the intestines or other tubular organs in one direction.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Chronic or recurrent colonic disorders without an identifiable structural or biochemical explanation. The widely recognized IRRITABLE BOWEL SYNDROME falls into this category.
A non-invasive imaging method that uses computed tomographic data combined with specialized imaging software to examine the colon.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
The action of a drug in promoting or enhancing the effectiveness of another drug.
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
Surgical creation of an external opening into the ILEUM for fecal diversion or drainage. This replacement for the RECTUM is usually created in patients with severe INFLAMMATORY BOWEL DISEASES. Loop (continent) or tube (incontinent) procedures are most often employed.
Preparations of Cassia senna and C. angustifolia (see SENNA PLANT). They contain sennosides, which are anthraquinone type CATHARTICS and are used in many different preparations as laxatives.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
A DNA repair pathway involved in correction of errors introduced during DNA replication when an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. Excinucleases recognize the BASE PAIR MISMATCH and cause a segment of polynucleotide chain to be excised from the daughter strand, thereby removing the mismatched base. (from Oxford Dictionary of Biochemistry and Molecular Biology, 2001)
A four carbon acid, CH3CH2CH2COOH, with an unpleasant odor that occurs in butter and animal fat as the glycerol ester.
A subclass of cyclooxygenase inhibitors with specificity for CYCLOOXYGENASE-2.
An enzyme of the transferase class that catalyzes the reaction 5,10-methylenetetrahydrofolate and dUMP to dihydrofolate and dTMP in the synthesis of thymidine triphosphate. (From Dorland, 27th ed) EC 2.1.1.45.
The growth of INTESTINAL POLYPS. Growth processes include neoplastic (ADENOMA and CARCINOMA) and non-neoplastic (hyperplastic, mucosal, inflammatory, and other polyps).
A yellow-orange dye obtained from tumeric, the powdered root of CURCUMA longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
One of two ganglionated neural networks which together form the enteric nervous system. The submucous (Meissner's) plexus is in the connective tissue of the submucosa. Its neurons innervate the epithelium, blood vessels, endocrine cells, other submucosal ganglia, and myenteric ganglia, and play an important role in regulating ion and water transport. (From FASEB J 1989;3:127-38)
A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).
A subcategory of mucins that contain SIALIC ACID.
Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.
Compounds or agents that combine with cyclooxygenase (PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES) and thereby prevent its substrate-enzyme combination with arachidonic acid and the formation of eicosanoids, prostaglandins, and thromboxanes.
A pathological condition characterized by the presence of a number of COLONIC DIVERTICULA in the COLON. Its pathogenesis is multifactorial, including colon aging, motor dysfunction, increases in intraluminal pressure, and lack of dietary fibers.
A rod-shaped, gram-positive, non-acid-fast, non-spore-forming, non-motile bacterium that is a genus of the family Bifidobacteriaceae, order Bifidobacteriales, class ACTINOBACTERIA. It inhabits the intestines and feces of humans as well as the human vagina.
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
A family of DNA-binding proteins that are primarily expressed in T-LYMPHOCYTES. They interact with BETA CATENIN and serve as transcriptional activators and repressors in a variety of developmental processes.
Wnt proteins are a large family of secreted glycoproteins that play essential roles in EMBRYONIC AND FETAL DEVELOPMENT, and tissue maintenance. They bind to FRIZZLED RECEPTORS and act as PARACRINE PROTEIN FACTORS to initiate a variety of SIGNAL TRANSDUCTION PATHWAYS. The canonical Wnt signaling pathway stabilizes the transcriptional coactivator BETA CATENIN.
An adenocarcinoma producing mucin in significant amounts. (From Dorland, 27th ed)
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
The combination of two or more different factors in the production of cancer.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
Tumors or cancer of the LUNG.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
A group of autosomal-dominant inherited diseases in which COLON CANCER arises in discrete adenomas. Unlike FAMILIAL POLYPOSIS COLI with hundreds of polyps, hereditary nonpolyposis colorectal neoplasms occur much later, in the fourth and fifth decades. HNPCC has been associated with germline mutations in mismatch repair (MMR) genes. It has been subdivided into Lynch syndrome I or site-specific colonic cancer, and LYNCH SYNDROME II which includes extracolonic cancer.

Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors. (1/8609)

The terminal colon is aganglionic in mice lacking endothelin-3 or its receptor, endothelin B. To analyze the effects of endothelin-3/endothelin B on the differentiation of enteric neurons, E11-13 mouse gut was dissociated, and positive and negative immunoselection with antibodies to p75(NTR )were used to isolate neural crest- and non-crest-derived cells. mRNA encoding endothelin B was present in both the crest-and non-crest-derived cells, but that encoding preproendothelin-3 was detected only in the non-crest-derived population. The crest- and non-crest-derived cells were exposed in vitro to endothelin-3, IRL 1620 (an endothelin B agonist), and/or BQ 788 (an endothelin B antagonist). Neurons and glia developed only in cultures of crest-derived cells, and did so even when endothelin-3 was absent and BQ 788 was present. Endothelin-3 inhibited neuronal development, an effect that was mimicked by IRL 1620 and blocked by BQ 788. Endothelin-3 failed to stimulate the incorporation of [3H]thymidine or bromodeoxyuridine. Smooth muscle development in non-crest-derived cell cultures was promoted by endothelin-3 and inhibited by BQ 788. In contrast, transcription of laminin alpha1, a smooth muscle-derived promoter of neuronal development, was inhibited by endothelin-3, but promoted by BQ 788. Neurons did not develop in explants of the terminal bowel of E12 ls/ls (endothelin-3-deficient) mice, but could be induced to do so by endothelin-3 if a source of neural precursors was present. We suggest that endothelin-3/endothelin B normally prevents the premature differentiation of crest-derived precursors migrating to and within the fetal bowel, enabling the precursor population to persist long enough to finish colonizing the bowel.  (+info)

Expression of nitric oxide synthase in inflammatory bowel disease is not affected by corticosteroid treatment. (2/8609)

AIM: To examine the effect of corticosteroid treatment on the expression of inducible nitric oxide synthase (iNOS) in the colon of patients with inflammatory bowel disease. METHODS: Four groups of patients were studied: (1) ulcerative colitis treated with high dose corticosteroids (six patients, 10 blocks); (2) ulcerative colitis patients who had never received corticosteroids (10 patients, 16 blocks); (3) Crohn's disease treated with high dose corticosteroids (12 patients, 24 blocks); (4) Non-inflammatory, non-neoplastic controls (four patients, six blocks). Full thickness paraffin sections of colons removed at surgery were immunostained with an antibody raised against the C terminal end of iNOS. Sections were assessed semiquantitatively for the presence and degree of inflammation and immunoreactivity for nitric oxide synthase. RESULTS: Cases of ulcerative colitis and Crohn's disease with active inflammation showed strong staining for nitric oxide synthase. The staining was diffuse in ulcerative colitis and patchy in Crohn's disease, in accordance with the distribution of active inflammation. Staining was seen in epithelial cells and was most intense near areas of inflammation such as crypt abscesses. Non-inflamed epithelium showed no immunoreactivity. Treatment with corticosteroids made no difference to the amount of nitric oxide synthase. CONCLUSIONS: Expression of nitric oxide synthase is increased in both ulcerative colitis and Crohn's disease and appears to be unaffected by treatment with corticosteroids. Disease severity necessitated surgery in all the cases included in this study, regardless of whether or not the patients had received long term corticosteroid treatment. It seems therefore that a high level of iNOS expression and, presumably, production of nitric oxide characterise cases which are refractory to clinical treatment; this suggests that specific inhibition of the enzyme may be a useful therapeutic adjunct.  (+info)

Colon and rectal anastomoses do not require routine drainage: a systematic review and meta-analysis. (3/8609)

OBJECTIVE: Many surgeons continue to place a prophylactic drain in the pelvis after completion of a colorectal anastomosis, despite considerable evidence that this practice may not be useful. The authors conducted a systematic review and meta-analysis of randomized controlled trials to determine if placement of a drain after a colonic or rectal anastomosis can reduce the rate of complications. METHODS: A search of the Medline database of English-language articles published from 1987 to 1997 was conducted using the terms "colon," "rectum," "postoperative complications," "surgical anastomosis," and "drainage." A manual search was also conducted. Four randomized controlled trials, including a total of 414 patients, were identified that compared the routine use of drainage of colonic and/or rectal anastomoses to no drainage. Two reviewers assessed the trials independently. Trial quality was critically appraised using a previously published scale, and data on mortality, clinical and radiologic anastomotic leakage rate, wound infection rate, and major complication rate were extracted. RESULTS: The overall quality of the studies was poor. Use of a drain did not significantly affect the rate of any of the outcomes examined, although the power of this analysis to exclude any difference was low. Comparison of pooled results revealed an odds ratio for clinical leak of 1.5 favoring the control (no drain) group. Of the 20 observed leaks among all four studies that occurred in a patient with a drain in place, in only one case (5%) did pus or enteric content actually appear in the effluent of the existing drain. CONCLUSIONS: Any significant benefit of routine drainage of colon and rectal anastomoses in reducing the rate of anastomotic leakage or other surgical complications can be excluded with more confidence based on pooled data than by the individual trials alone. Additional well-designed randomized controlled trials would further reinforce this conclusion.  (+info)

Segmental colonic transit after oral 67Ga-citrate in healthy subjects and those with chronic idiopathic constipation. (4/8609)

Measurement of segmental colonic transit is important in the assessment of patients with severe constipation. 111In-diethylenetriamine pentaacetic acid (DTPA) has been established as the tracer of choice for these studies, but it is expensive and not readily available. 67Ga-citrate is an inexpensive tracer and when given orally is not absorbed from the bowel. It was compared with 111In-DTPA in colonic transit studies in nonconstipated control subjects and then in patients with idiopathic constipation. METHODS: Studies were performed after oral administration of 3 MBq (81 microCi) 67Ga-citrate or 4 MBq (108 microCi) 111In-DTPA in solution. Serial abdominal images were performed up to 96 h postinjection, and computer data were generated from geometric mean images of segmental retention of tracer, mean activity profiles and a colonic tracer half-clearance time. RESULTS: There were no differences in segmental retention of either tracer or in mean activity profiles between control subjects and constipated patients. Results in constipated subjects were significantly different from those in controls. The mean half-clearance times of tracer for control subjects were 28.8 h for 67Ga-citrate and 29.9 h for 111In-DTPA in control subjects and 75.0 h for 67Ga-citrate and 70.8 h for 111In-DTPA in constipated patients. CONCLUSION: Oral 67Ga-citrate can be used as a safe alternative to 111In-DTPA for accurate measurement of segmental colonic transit.  (+info)

Modulation of distal colonic epithelial barrier function by dietary fibre in normal rats. (5/8609)

BACKGROUND: Dietary fibre influences the turnover and differentiation of the colonic epithelium, but its effects on barrier function are unknown. AIMS: To determine whether altering the type and amount of fibre in the diet affects paracellular permeability of intestinal epithelium, and to identify the mechanisms of action. METHODS: Rats were fed isoenergetic low fibre diets with or without supplements of wheat bran (10%) or methylcellulose (10%), for four weeks. Paracellular permeability was determined by measurement of conductance and 51Cr-EDTA flux across tissue mounted in Ussing chambers. Faecal short chain fatty acid (SCFA) concentrations were assessed by gas chromatography, epithelial kinetics stathmokinetically, and mucosal brush border hydrolase activities spectrophotometrically. RESULTS: Body weight was similar across the dietary groups. Conductance and 51Cr-EDTA flux were approximately 25% higher in animals fed no fibre, compared with those fed wheat bran or methylcellulose in the distal colon, but not in the caecum or jejunum. Histologically, there was no evidence of epithelial injury or erosion associated with any diet. The fibres exerted different spectra of effects on luminal SCFA concentrations and pH, and on mucosal indexes, but both bulked the faeces, were trophic to the epithelium, and stimulated expression of a marker of epithelial differentiation. CONCLUSIONS: Both a fermentable and a non-fermentable fibre reduce paracellular permeability specifically in the distal colon, possibly by promoting epithelial cell differentiation. The mechanisms by which the two fibres exert their effects are likely to be different.  (+info)

The role of psychological and biological factors in postinfective gut dysfunction. (6/8609)

BACKGROUND: Both psychological and physiological disturbances have been implicated in the aetiopathogenesis of irritable bowel syndrome (IBS). AIMS: To investigate how the psychological factors act, and the involvement of infective and physiological factors. METHODS: Consecutive patients hospitalised for gastroenteritis reported life events for the previous 12 months, and past illness experiences on standardised questionnaires. They also completed psychometric questionnaires for anxiety, neuroticism, somatisation, and hypochondriasis. In some patients, rectal biopsy specimens were obtained during the acute illness and at three months postinfection. RESULTS: Ninety four patients completed all questionnaires: 22 patients were diagnosed with IBS after their gastroenteritis (IBS+), and 72 patients returned to normal bowel habits (IBS-). IBS+ patients reported more life events and had higher hypochondriasis scores than IBS- patients. The predictive value of the life event and hypochondriasis measures was highly significant and independent of anxiety, neuroticism, and somatisation scores, which were also elevated in IBS+ patients. Rectal biopsy specimens from 29 patients showed a chronic inflammatory response in both IBS+ and IBS- patients. Three months later, specimens from IBS+ patients continued to show increased chronic inflammatory cell counts but those from IBS- patients had returned to normal levels. IBS+ and IBS- patients exhibited rectal hypersensitivity and hyper-reactivity and rapid colonic transit compared with normal controls, but there were no significant differences between IBS+ and IBS- patients for these physiological measurements. CONCLUSION: Psychological factors most clearly predict the development of IBS symptoms after gastroenteritis but biological mechanisms also contribute towards the expression of symptoms.  (+info)

Is early post-operative treatment with 5-fluorouracil possible without affecting anastomotic strength in the intestine? (7/8609)

Early post-operative local or systemic administration of 5-fluorouracil (5-FU) is under investigation as a means to improve outcome after resection of intestinal malignancies. It is therefore quite important to delineate accurately its potentially negative effects on anastomotic repair. Five groups (n = 24) of rats underwent resection and anastomosis of both ileum and colon: a control group and four experimental groups receiving daily 5-FU, starting immediately after operation or after 1, 2 or 3 days. Within each group, the drug (or saline) was delivered either intraperitoneally (n = 12) or intravenously (n = 12). Animals were killed 7 days after operation and healing was assessed by measurement of anastomotic bursting pressure, breaking strength and hydroxyproline content. In all cases, 5-FU treatment from the day of operation or from day 1 significantly (P<0.025) and severely suppressed wound strength; concomitantly, the anastomotic hydroxyproline content was reduced. Depending on the location of the anastomosis and the route of 5-FU administration, even a period of 3 days between operation and first dosage seemed insufficient to prevent weakening of the anastomosis. The effects of intravenous administration, though qualitatively similar, were quantitatively less dramatic than those observed after intraperitoneal delivery. Post-operative treatment with 5-FU, if started within the first 3 days after operation, is detrimental to anastomotic strength and may compromise anastomotic integrity.  (+info)

Low tumour cell proliferation at the invasive margin is associated with a poor prognosis in Dukes' stage B colorectal cancers. (8/8609)

The conflicting results about the prognostic impact of tumour cell proliferation in colorectal cancer might be explained by the heterogeneity observed within these tumours. We have investigated whether a systematic spatial heterogeneity exists between different compartments, and whether the presence of such a systematic heterogeneity has any impact on survival. Fifty-six Dukes' stage B colorectal cancers were carefully morphometrically quantified with respect to the immunohistochemical expression of the proliferative marker Ki-67 at both the luminal border and the invasive margin. The proliferative activity was significantly higher at the luminal border compared with the invasive margin (P<0.001), although the two compartments were also significantly correlated with each other. Tumours with low proliferation at the invasive margin had a significantly poorer prognosis both in univariate (P = 0.014) and in multivariate survival analyses (P = 0.042). We conclude that Dukes' B colorectal cancers exhibit a systematic spatial heterogeneity with respect to proliferation, and tumours with low proliferation at the invasive margin had a poor prognosis. The present data independently confirm recent results from the authors, and provide new insights into the understanding of tumour cell proliferation in colorectal cancer.  (+info)

Mouse Colonic Smooth Muscle Cells from Creative Bioarray are isolated from tissue of pathogen-free laboratory mice. Mouse Colonic Smooth Muscle Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based solution for 0.5 hour and incubated in Creative Bioarrays Cell Culture Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1x10^6 cells per ml and is delivered frozen ...
Crypt restricted heterogeneity of goblet cell mucus glycoprotein in histologically normal human colonic mucosa: a potential marker of somatic mutation
MEKK1-MKK4-JNK-AP1 Pathway Negatively Regulates Rgs4 Expression in Colonic Smooth Muscle Cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
BACKGROUND: The predominant colonic short chain fatty acids, acetate, propionate, and butyrate, are oxidised into CO2 in colonocytes from rat and humans in the preferred order of butyrate (C4) , propionate (C3) , acetate (C2)- hence butyrate is considered to be the principal oxidative substrate for colonocytes. AIMS: To compare colonocyte oxidation of valerate (C5), hexanoate (C6), and octanoate (C8) with that of butyrate. METHODS: Isolated rat colonocytes were incubated in the presence of a concentration range of 1-14C labelled C2-C8 fatty acids. Oxidation rates were obtained by quantifying the production of 14CO2, and Vmax (maximum velocity) and K(m) (Michaelis-Menten constant) were calculated by computer fitting of the data to a Michaelis-Menten plot. RESULTS: The K(m) value of acetate (0.56 (SEM 0.02) mmol/l) was about fourfold higher than the K(m) of butyrate (0.13 (0.01) mmol/l), whereas the K(m) values of valerate (0.19 (0.01) mmol/l), hexanoate (0.19 (0.01) mmol/l), and octanoate (0.16 ...
TY - JOUR. T1 - The Crohns disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells. AU - Matthews, Stephen M.. AU - Eshelman, Melanie A.. AU - Berg, Arthur S.. AU - Koltun, Walter A.. AU - Yochum, Gregory S.. PY - 2019/2. Y1 - 2019/2. N2 - Crohns disease (CD) is a debilitating inflammatory bowel disease (IBD) that arises from chronic inflammation in the gastrointestinal tract. Genome-wide association studies (GWAS) have identified over 200 single nucleotide polymorphisms (SNPs) that are associated with a predisposition for developing IBD. For the majority, the causal variant and target genes affected are unknown. Here, we investigated the CD-associated SNP rs6651252 that maps to a gene desert region on chromosome 8. We demonstrate that rs6651252 resides within a Wnt responsive DNA enhancer element (WRE) and that the disease associated allele augments binding of the TCF7L2 transcription factor to this region. Using CRISPR/ Cas9 directed gene editing and ...
Increased mucosal infiltration by leucocytes is a characteristic feature of inflammatory bowel disease and chemotactic factors play a key role in the recruitment of inflammatory cells. Intestinal epithelial cells act as the interface between the contents of the gut lumen and the internal milieu, which places them in an ideal position to detect and respond to proinflammatory stimuli.. In this study we have shown that human colonic cell lines, HT29-19A and Caco-2, express distinct patterns of chemokine secretion, both constitutively and after stimulation by inflammatory agonists. HT29-19A cells, which have a phenotype similar to that expected of Cl− secretory cells in the crypt epithelium,18 secreted high levels of both IL-8 and GROα, primarily in response to TNF-α and IL-1. These chemokines were secreted in parallel, probably via a common pathway as judged by their virtually identical time course for secretion and dose responsiveness to cytokine stimulation, suggesting that they may have ...
B129 Mouse Colonic Microvascular Endothelial Cells from Creative Bioarray are isolated from colonic tissue of pathogen-free laboratory B129S2/SvPasCrl mice. B129 Mouse Colonic Microvascular Endothelial Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based coating solution for 2 min and incubated in Creative Bioarray Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 1x10^6 cells per ml and are delivered frozen. The method we use to isolate endothelial cells was developed based on a combination of established and our proprietary methods. These cells are pre-coated with PECAM-1 antibody, following the application of magnetic pre-coated with secondary antibody ...
Distorted bands from human colon samples - posted in SDS-PAGE and Western Blotting: I have been running western blots for some time now and I am having difficulty running some human colon samples that perhaps I could get advice on. In brief my protocol is as follows: To 0.12g of colon tissue, I add 1ml of RIPA (0.96g Tris, 3.5g NaCL, 0.24g EDTA, 0.3g EGTA, 4g Na Doxycholate, 4ml Triton-X 100, 4ml 10% SDS, made up to 400ml with dH2). I leave the tissue in RIPA for 10 mins on ice, after whic...
HLA-DR+ gut epithelial cells may present antigen to intraepithelial lymphocytes (IEL). This study aimed to isolate an IEL population from the human colon to activate CD3 + IEL by a human colonic epithelial cell line (HT-29), bearing different concentrations of class II antigen (HLA-DR). IEL were isolated by a mechanical method from six patients with ulcerative colitis (UC) and from 14 control patients. IEL were cocultured with HT-29 which had been induced to express class II molecules by gamma-interferon (IFN-gamma) in a dose dependent manner. The phenotype and the subsequent expression of activation markers by the IEL were determined to two colour flow cytometry. The IEL population had a CD4/CD8 ratio similar to that seen in tissue sections. In the mixed cell culture, the degree of IEL activation showed a positive correlation with the degree of HLA-DR expression by the HT29 cells and the IEL secreted a IFN-gamma like factor that in turn stimulated the HT-29. Thus, depending on their expression of HLA
TY - JOUR. T1 - The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis. AU - Jin, Guangchun. AU - Sakitani, Kosuke. AU - Wang, Hongshan. AU - Jin, Ying. AU - Dubeykovskiy, Alexander. AU - Worthley, Daniel L.. AU - Tailor, Yagnesh. AU - Wang, Timothy C.. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Overexpression of human progastrin increases colonic mucosal proliferation and colorectal cancer progression in mice. The G-protein coupled receptor 56 (GPR56) is known to regulate cell adhesion, migration, proliferation and stem cell biology, but its expression in the gut has not been studied. We hypothesized that the promotion of colorectal cancer by progastrin may be mediated in part through GPR56. Here, we found that GPR56 expresses in rare colonic crypt cells that lineage trace colonic glands consistent with GPR56 marking long-lived colonic stem-progenitor cells. GPR56 was upregulated in transgenic mice overexpressing human ...
Author(s): Mills SJ, Mathers JC, Chapman PD, Burn J, Gunn A. Publication type: Article. Publication status: Published. Journal: Gut. Year: 2001. Volume: 48. Issue: 1. Pages: 41-46. ISSN (print): 0017-5749. ISSN (electronic): 1468-3288. Publisher: BMJ Publishing Group Ltd. URL: http://dx.doi.org/10.1136/gut.48.1.41. DOI: 10.1136/gut.48.1.41. ...
This project aims to better understand the role of Src kinase on the development of colon cancer. Enhanced Src expression and activity are commonly elevated in colon cancer, with progressively higher activity observed as tumors progress and metastasize, however, the specific mechanism by which Src promotes cancer progression are still under investigation. First, we examined the potential for biological cooperativity between APC (adenomatous polyposis coli), a tumor suppressor often mutated in early stages of colon cancer, and elevated Src activity, using conditionally immortalized mouse colon epithelial cell lines, IMCE (APC +/min) and YAMC (APC +/+) as a model. The APC genotype did not affect the ability of Src to disrupt cell-cell junctions and promote cell invasiveness. However, IMCE cells exhibited increased capacity for oncogenic Src-mediated anchorage-independent proliferation as compared to YAMC cells. This property was correlated with enhanced â-catenin expression and activity, but not ...
The aim of this project was to develop a system using the methods and techniques of computerised image processing and analysis in order to quantitatively describe patterns of movement in smooth muscle. The algorithms developed have been applied to the investigation of the co-ordination of motility of rabbit colon in vitro. The MAGISCAN 2 image processor used in this project is designed to analyse single still photographic images from a television camera. In the analysis of movement it is essential to process sequences of images with respect to time. These must be captured at a rate much faster than the period of the movements being investigated. To define precisely complex movements such as gut peristalsis large data sets must be used. Typically this requires the processing of several thousand photographs, the photographs being taken at a rate of three frames/sec over a period of half an hour. The most efficient way to achieve this is to capture, fully analyse and store the derived parameters of ...
|i|Background|/i|. Type 2 diabetes mellitus (T2DM) is determined by genetic and environmental factors. There have been many studies on the relationship between the composition of the gastrointestinal bacterial flora, T2DM, and obesity. There are no data, however, on the gut microbiome structure in monogenic forms of the disease including Maturity Onset Diabetes of the Young (MODY).|i| Methods|/i|. The aim of the investigation was to compare the qualitative parameters of the colonic flora in patients with HNF1A|i|-|/i|MODY and T2DM and healthy individuals. 16S sequencing of bacterial DNA isolated from the collected fecal samples using the MiSeq platform was performed.|i| Results|/i|. There were significant between-group differences in the bacterial profile. At the phylum level, the amount of Proteobacteria was higher (|svg xmlns:xlink=http://www.w3.org/1999/xlink xmlns=http://www.w3.org/2000/svg style=vertical-align:-3.42938pt id=M1 height=11.7782pt version=1.1 viewBox=-0.0498162 -8.34882 57
High-end custom furniture provided by Samuelson Furniture in collaboration with Design @ Teresa Dos Santos & Purchasing @ Cooper Hotels to deliver on the design intent. Functionality and engineering ...
We present a theoretical and computational framework to model the colonic crypt organisation in the human intestine. We construct a theoretical and computational framework to model the colonic crypt b
in NVP-BHG712 viable cells was eluted from the cells with a mixture of acetic acid, ethanol and water . The plates were agitated on a micro titer plate shaker
A29 (Background) It has been estimated that approximately 1010 of normal adult colonic epithelial cells, each having a lifespan of 3-4days, are shed daily from the lower two-thirds of colon crypts; thus, using colonocytes to develop a screening test is an attainable goal. There is a need for sensitive and specific diagnostic and prognostic molecular markers which can monitor early patterns of gene expression in non-invasive exfoliated colonocytes shed in the stool. There were a few studies of RNA -based detection method because of the characteristics in stool. We report here the mass RNA analysis using stool in colorectal cancer. (Method) The study included 15 patients with colorectal cancer, and 15 control patients without neoplastic disease of the colon and rectum. RNA was isolated from routinely collected stool samples using a modified method. The expression levels of survivin, livin, Akt-1, caveolin, histone deacetylase(HDAC)1, matrix metalloproteinases(MMP)-2, MMP-7, MMP-9, MMP-12, hepatoma ...
The Jets have their starting offensive line set for 2014 after re-signing right guard Willie Colon on Wednesday. The $2 million contract is for one year,...
Interleukin 10 inhibits interferon γ- and tumor necrosis factor α-stimulated activation of NADPH oxidase 1 in human colonic epithelial cells and the mouse colon (2009 ...
Both of my older brothers had colon cancer; the oldest died at 36 and the other lost his colon at 48. This was when my family learned that we hold the mutation for Lynch syndrome. Lynch syndrome is an inherited disorder that increases your risk for a dozen different early onset cancers, particularly cancers of the colon and rectum. My particular mutation also holds implications for cancer of the stomach, small intestine, liver, gallbladder ducts, upper urinary tract, brain and skin.
Download Celia and Willie by Celia Cruz and Willie Colon at MP3mixx.com! High Quality, Preview Available. Songs start at just $0.15!
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During this evolution from the gut pathology mentioned while in the documents to what was published inside the paper, boy or girl threes case is a primary illustration. Just after ileocolonoscopy (which, GMC prosecution and defence gurus agreed, was not clinically indicated116), the hospitals pathologists identified all colonic samples to generally be inside normal histological limits ...
Official Post from Youre A Kitty! Studio by Giselle Colon: Ive updated the price tiers to reflect adding cosplay into all of this! I know I have some people at the $5 tier that are donating $10 so if youd like all the benefits of the $10 tier then go to Edit your patronage (or something like that) and you can select the $10 tier. Im pretty sure it does
Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Please contact the study team to discuss whether or not you are eligible to participate in a study.. ...
Wcap are said/such/same two majalternatively dominant parts of human consequentlycover win view of the fact thatte: colonic, rectum, alternatively anusAnswer:Maikang Your enquiry is confusing. The colonic abconsequently...
TY - JOUR. T1 - Effect of fluid perfusion and cleansing on canine colonic motor activity. AU - Sarna, S. K.. PY - 1992. Y1 - 1992. N2 - We investigated the effect of absorbable and nonabsorbable fluid perfusion and cleansing on colonic motor activity in eight intact conscious dogs. Each dog was instrumented with an indwelling catheter in the proximal colon and seven strain gauge transducers on the entire colon. After an overnight fast, a control recording was made for 3 h, followed by 3 h of perfusion and 3 additional h of postperfusion recording. Next day, a 3-h recording was made when the colon was empty. The colon exhibited normal migrating and nonmigrating motor complexes in the control uncleansed state. The perfusion of absorbable electrolyte or nonabsorbable Colyte solution immediately disrupted the migrating motor complexes and replaced them with almost continuous but irregular contractions at all recording sites. Both solutions significantly prolonged the mean and total duration per hour ...
Charrier , C , Duncan , G J , Reid , M D , Rucklidge , G J , Henderson , D , Young , P , Russell , V J , Aminov , R I , Flint , H J & Louis , P 2006 , A novel class of CoA-transferase involved in short-chain fatty acid metabolism in butyrate-producing human colonic bacteria Microbiology , vol 152 , no. 1 , pp. 179-185 . DOI: 10.1099/MIC.0.28412- ...
TY - JOUR. T1 - Aquaporin-8 is involved in water transport in isolated superficial colonocytes from rat proximal colon. AU - Laforenza, Umberto. AU - Cova, Emanuela. AU - Gastaldi, Giulia. AU - Tritto, Simona. AU - Grazioli, Monica. AU - LaRusso, Nicholas F.. AU - Splinter, Patrick L.. AU - DAdamo, Patrizia. AU - Tosco, Marisa. AU - Ventura, Ulderico. N1 - Copyright: Copyright 2020 Elsevier B.V., All rights reserved.. PY - 2005/10. Y1 - 2005/10. N2 - Water is an essential nutrient because it must be introduced from exogenous sources to satisfy metabolic demand. Under physiologic conditions, the colon can absorb and secrete considerable amounts of water even against osmotic gradients, thus helping to maintain the body fluid balance. Here we describe studies on both aquaporin (AQP) expression and function using cells isolated from the superficial and lower crypt regions of the rat proximal colon. The expression of AQP-3, -4, and -8 in isolated colonocytes was determined by semiquantitative RT-PCR ...
The presence of RON and its variant isoform in malignant and non-malignant human colonic tissues was examined by immunohistochemistry using paraffin-embedded sections and RT-PCR analysis followed by direct sequencing of PCR product using RNAs isolated from frozen tissues. In normal colonic mucosa, R …
TY - JOUR. T1 - Prolonged ambulatory monitoring of colonic motor activity in the pig. AU - Crowell, M. D.. AU - Musial, F.. AU - French, W.. AU - Kittur, D.. AU - Anderson, D.. AU - Whitehead, W. E.. PY - 1992/9. Y1 - 1992/9. N2 - The aim of this study was to develop a chronic model suitable for repeated, long-term studies of the interaction of behavior and colonic function in unrestrained pigs. Cecostomies were created in three 20-30 kg micropigs under general anesthesia. Fistulas were created by suturing the bowel to the abdominal wall. Recordings were made by passing a small (8F) solid-state pressure transducer through the fistula into the proximal bowel and connecting it to a battery-operated data logger worn in a vest on the pigs back. Cecostomies have remained patent and trouble-free for over 18 months. No serious infections have occurred. Preliminary data from a total of thirteen 24-h recording sessions showed 54% of all contractile activity to be in the 2-4 cpm frequency range. ...
TY - JOUR. T1 - Effect of Orlistat on Fecal Fat, Fecal Biliary Acids, and Colonic Cell Proliferation in Obese Subjects. AU - Ahnen, Dennis J.. AU - Guerciolini, Roberto. AU - Hauptman, Jonathan. AU - Blotner, Steven. AU - Woods, Cindy J.. AU - Wargovich, Michael J.. PY - 2007/11/1. Y1 - 2007/11/1. N2 - Background & Aims: Orlistat is a weight management agent that selectively inhibits gastrointestinal lipase activity. Because of orlistats mode of action, increased fecal fat is presented to the colonic mucosa, and fecal bile acid and free fatty acid composition may be altered during treatment. Our aim was to assess the effect of treatment of obese subjects with orlistat 120 mg 3 times a day for 6 weeks on fecal lipid and bile acid parameters and colonic mucosal cell proliferation. Methods: Twenty-four obese (body mass index, 30-40 kg/m2) but otherwise healthy male and female subjects were enrolled in a single-center, randomized, double-blind, placebo-controlled, parallel-group study. Participants ...
Reynolds, Amy, Addison, S., Lindqvist, Susanne and Williams, Mark (2005) Propagating calcium signals along human colonic crypts dynamically regulate NKCC1 phosphorylation and activity. Gastroenterology, 128. pp. 357-358. ISSN 1528-0012 Full text not available from this repository. (Request a copy ...
The relationship between intestinal epithelial integrity and the development of intestinal disease is of increasing interest. A reduction in mucosal integrity has been associated with ulcerative colitis, Crohns disease and potentially could have links with colorectal cancer development. The Ussing chamber system can be utilised as a valuable tool for measuring gut integrity. Here we describe step-by-step methodology required to measure intestinal permeability of both mouse and human colonic tissue samples ex vivo, using the latest equipment and software. This system can be modified to accommodate other tissues. An Ussing chamber was constructed and adapted to support both mouse and human tissue to measure intestinal permeability, using paracellular flux and electrical measurements. Two mouse models of intestinal inflammation (dextran sodium sulphate treatment and T regulatory cell depletion using C57BL/6-FoxP3DTR mice) were used to validate the system along with human colonic biopsy samples. Distinct
The relationship between intestinal epithelial integrity and the development of intestinal disease is of increasing interest. A reduction in mucosal integrity has been associated with ulcerative colitis, Crohns disease and potentially could have links with colorectal cancer development. The Ussing chamber system can be utilised as a valuable tool for measuring gut integrity. Here we describe step-by-step methodology required to measure intestinal permeability of both mouse and human colonic tissue samples ex vivo, using the latest equipment and software. This system can be modified to accommodate other tissues. An Ussing chamber was constructed and adapted to support both mouse and human tissue to measure intestinal permeability, using paracellular flux and electrical measurements. Two mouse models of intestinal inflammation (dextran sodium sulphate treatment and T regulatory cell depletion using C57BL/6-FoxP3DTR mice) were used to validate the system along with human colonic biopsy samples. Distinct
Recently, we delineated the mechanism in which graft-versus-host disease (GVHD), the major detrimental effect of allogeneic bone marrow transplantation, is enhanced by pathogenic colon-derived donor dendritic cells (DC) in a murine model. First, we will find the genetic signature of these DC using RNA sequence assay. Secondly, we will identify the equivalent human DC from post-transplant patients blood sample. The genetic profile of pathogenic colon-derived DC will provide us with a powerful biomarker to predict and treat severe GVHD. ...
TY - JOUR. T1 - Measurement of the Nucleus Area and Nucleus/Cytoplasm and Mitochondria/Nucleus Ratios in Human Colon Tissues by Dual-Colour Two-Photon Microscopy Imaging. AU - Su Lim, Chang. AU - Kim, Eun-Sun. AU - Yeon Kim, Ji. AU - Taek Hong, Seung. AU - Chun, Hoon-Jai. AU - Eun Kang, Dong. AU - Cho, Bong-Rae. PY - 2015/12/17. Y1 - 2015/12/17. N2 - We developed two-photon (TP) probes for DNA (ABI-Nu), cytoplasm (Pyr-CT), and mitochondria (BF-MT). We found that ABI-Nu binds to AT in the minor groove, while ABI-Nu and BF-MT are effective for tracking in the cytoplasm and mitochondria, respectively. These probes showed very large effective two-photon action cross section values of 2230, 1555, and 790 Göppert-Mayer units (1GM=10-50 cm4s photon-1 molecule-1) at 740nm with emission maxima at 473, 561, and 560nm, respectively, in each organelle. Using these probes, we quantitatively estimated the mean nuclear area and the ratios of nuclei to cytoplasm and mitochondria to nuclei in human colon ...
Descending rabbit colon, stripped ofmuscularis externa, absorbs Na and Cl under short-circuit conditions and exhibits a residual ion flux, consistent with HCO3 secretion, whose magnitude is approximately equal to the rate of active Cl absorption. Net K transport was not observed under short-circuit conditions. The results of ion replacement studies and of treatment with ouabain or amiloride suggest that the short-circuit currentI sc is determined solely by the rate of active Na transport and that the net movements of Cl and HCO3 are mediated by a Na-independent, electrically-neutral, anion exchange process. Cyclic AMP stimulates an electrogenic Cl secretion, abolishes HCO3 secretion but does not affect the rate of Na absorption under short-circuit conditions. Studies of the effect of transepithelial potential difference on the serosa-to-mucosa fluxesJ sm i of Na, K and Cl suggest thatJ sm Na ,J sm K and one-third ofJ sm Cl may be attributed to ionic diffusion. The permeabilities of the passive
博士論文. Volume regulation is one of the most important cell functions to maintain cell homeostasis in a variety of physiological and pathological conditions, where cells are subject to osmotic perturbation. Although colon crypts have been reported to shrink during Cl,SUP,-,/SUP, secretion in response to secretagogue stimulation, it is not yet clear whether or how individual secretory cells located in colon crypts restore their cell volume. To study this, he visualized individual cells in the crypt isolated from the guinea pig distal colon using two-photon laser scanning microscopy, and their volume changes in response to carbachol (CCh), a cholinergic agonist, were compared with those of a human colonic epithelial T84 cell line. Both T84 cells and fundus crypt cells, but not upper crypt cells, showed shrinkage (termed a secretory volume decrease: SVD) after CCh stimulation, and surprisingly, even under continuous stimulation by CCh, they recovered their original cell volume (called a ...
We (30) have recently reported that the majority of mouse LS colon sensory neurons respond to heat, protons, and capsaicin, consistent with the expression of TRPV1 channels. In the present report, we examined, in greater detail, the acid-sensitive currents in this population of colon sensory neurons as well as in a second TL sensory pathway innervating the distal colon. We found that visceral sensory neurons labeled from the colon are functionally distinct from unlabeled neurons, which likely project to nonvisceral targets, such as the skin or muscle. Whereas most unlabeled DRG neurons generated transient amiloride-sensitive currents in response to acid, most LS and TL colon sensory neurons responded with slowly activating, sustained currents that were reversibly inhibited by the TRPV1 blocker capsazepine. Consistent with the role of TRPV1 as the principal mediator of acid-sensitive currents in colon sensory neurons, the peak current and fraction of neurons responding to acid were significantly ...
TY - JOUR. T1 - Ureteral replacement with reconfigured colon substitute. AU - Pope, John. AU - Koch, Michael. PY - 1996/5. Y1 - 1996/5. N2 - Purpose: Upper ureteral defects are often too extensive to repair by direct anastomosis or with use of a bladder flap. Ureteral substitution may be the only remaining alternative to restoring urinary drainage from the kidney to the bladder. This effect is usually achieved by interposing a segment of small bowel between the proximal collecting system and bladder. If ileum is not available other substitution alternatives must be sought. Materials and Methods: We report a new technique in which a tube constructed from a small piece of ascending colon was used to replace a large ureteral defect. Results: Excellent short-term results were achieved by replacing the strictured ureteral segment with a reconfigured colon segment as shown by symptomatic and radiographic improvement. Conclusions: A reconfigured colon segment can be used for ureteral reconstruction in ...
Aldosterone is a major regulator of Na+-absorptive and K+-secretory processes in the distal segment of mammalian colon. In this study, the distribution of aldosterone-sensitive cell types in isolated rat distal colon was determined using site-directed intracellular microelectrodes, specific Na+- and K+-channel blockers, and aldosterone-receptor binding techniques. Electrophysiological data indicated that aldosterone induced parallel apical membrane Na+ and K+ conductances, mainly in surface cells and to a significantly lesser degree in crypt cells. Scatchard analyses of aldosterone-receptor binding in cytosolic fractions revealed the maximum number of specific binding sites in whole mucosal homogenate and in the upper one-third and lower two-thirds of isolated crypt units to be 74.9 ± 2.0, 59.8 ± 2.4, and 59.3 ± 3.2 fmol/mg protein, respectively, indicating the presence of aldosterone receptors in the crypt cell population. We conclude that in rat distal colon aldosterone-induced Na+ and K+ ...
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Colorectal cancer (CRC) is a highly heterogeneous disease worldwide. Long non‑coding RNA (lncRNA) tumor suppressor candidate 7 (TUSC7) plays a crucial role in the development of several cancers. However, the role of TUSC7 in the tumorigenesis of CRC has not been explored. The TUSC7‑overexpressing CRC cell lines SW480 and CaCo‑2 were generated to investigate the effects of TUSC7 on the growth, migration, invasion and epithelial‑mesenchymal transition (EMT) of CRC cells. CCK‑8, wound‑healing and Transwell assays were used to evaluate CRC cell proliferation, migration and invasion. The mRNA and protein expression of TUSC7 were detected by quantitative real‑time PCR and immunoblotting, respectively. In the present study, we observed that the expression of TUSC7 was decreased in CRC cells compared to the expression in the normal colon epithelial cell line NCM460. Moreover, overexpression of TUSC7 inhibited CRC cell proliferation, metastasis, invasion and EMT. These findings indicated ...
Ascending Colon Membrane Lysate Catalog Number: XBL-10523 By Type: Tissue Species: Human Diagnosis: Normal Tested Applications: WB Size: 0.1 mg ...
In development of colorectal cancer (CRC), stem cell (SC) overpopulation underlies tumor initiation and progression, but it is incompletely understood which dysregulated mechanisms cause SC overpopulation. Because neuroendocrine cell (NEC) and SC populations both reside in the SC niche at the normal crypt bottom, we hypothesized that i) NECs play a role in maintaining the SC population, and ii) changes in the NEC population contributes to SC overpopulation and altered epithelial: stromal interactions during tumorigenesis. Immunofluorescence mapping and flow cytometry were used to analyze SC niche structure and cell-cell interactions in normal and neoplastic colonic tissues from Caucasian and African-American patients. In normal colonic crypts, most cells (77%) staining positively for the colonic SC marker ALDH1, also co-stained for the NE cell marker chromogranin-A (CGA). In the progression from normal to normal-appearing FAP to adenomatous to malignant colonic tissue, the proportion of ...
Hello [ColleagueName], I found this podcast titled Geoffrey Colon on Disruptive Marketing on the AMA Website that may help in professional development. You can find out more about it here, Geoffrey Colon on Disruptive ...
Despite there being no clearcut advantages, one of the most common recommendations in IBS management is to increase the amount of dietary fibres. In some IBS patients fibres have a deleterious effect on pain and bloating. It has been shown that butyrate can increase colonic sensitivity in rats. Our purpose is to study whether butyrogenic fibres can modify rectal sensitivity and symptoms in IBS and healthy control through a modification of colonic flora ...
Health, table width 218 border 0 cellspacing ...a target _self href http://www.eurekalert.org/multimedia/pub/12012...,Inflammation,in,colon,may,get,doused,before,fueling,cancer,development,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
Another perplexing aspect of the /32-microglobulin association of CD1 proteins has recently been demonstrated by a report of P2microglobulin-independent expression of the human C D l d protein by intestinal epithelial cells. Immunoprecipitations from lysates of =I-labeled normal colonic epithelial cells performed with these mAbs, or with a mAb raised against a bacterial fusion protein constructed from the human C D l d cDNA sequence (Bilsland and Milstein, 1991), revealed a 100-kDa band under nonreducing conditions and a single 37-kDa band after reduction. 1987a). In similar fashion, two separate epitopes have been defined on the C D l b molecule, whereas the four anti-CDlc mAbs so far examined in this fashion appear to bind to the same or overlapping epitopes (Amiot et al. 1986, 1987b; Favaloro et al. 1987a). The relationship of these serologic epitopes to the protein structure of CD1 is currently unknown. , 1989). This variable reactivity with trypsin-cleaved CDla further underscores the ...
Im getting surgery on Match 6th, removing 80 percent of my colon at first. (Three stage surgery) Ive been prescribed Flagyl and Pred. I was wondering if...
This formula is for Killing Parasites Blood cleansing Colon detox Paraherb is used for the elimination of all bodily parasites including their eggs. It also cleans the blood and detoxifies the colon at the same time. It should be taken.... ...
In the UK alone the statistics make sombre reading. Did you know that most people can suffer with problems in their colon at some time in their life, those less fortunate suffer long term? Its one of those subjects that no-one wants to openly discuss either and that means you may not get support when you need it and you may not have the information you need to make informed choices. Understanding is part of the key and thats what this website is about. Because your Colon works to eliminate waste from your body it is an integral part of keeping you well and healthy.. The colon works hard on your behalf clearing the toxins that enter your system and trying to evacuate the toxins on a regular basis. Help your colon to help yourself! As your colon acts as the sewage system for your body you can get problems if it gets blocked or overloaded. Think about the effects a blocked or faulty sewer would have on your home.. ...
The Mets arent expected to make Bartolo Colon available at this years trade deadline, Andy Martino of the New York Daily News reports, barring a situation where trading him would somehow directly improve their playoff chances. Colon, Dillon Gee and Jon Niese were all being shopped by the Mets during the offseason but none were dealt, a non-move that could end up being a prudent one for the team given that Zack Wheeler was lost for the season due to Tommy John surgery.. Colon has essentially been seen as a trade candidate ever since he signed his two-year, $20MM free agent contract in January 2014. As Martino puts it, the Mets might has well have issued Colon a jersey with PLACEHOLDER on the back as the thinking was that the Mets would eventually use the veteran as a trade chip once one of their younger arms was ready to take his spot in the rotation. The Mets didnt get much interest about Colon at last years trade deadline, however, and despite testing his market over the winter, the ...
Learn more about Pólipos de Colon at Portsmouth Regional Hospital DefiniciónCausasFactores de riesgoSíntomasDiagnósticoTratamientoPrevenció...
Learn more about Angiodisplasia del Colon at Medical City Dallas DefiniciónCausasFactores de RiesgoSíntomasDiagnósticoTratamientoPrevenció...
Researchers have identified an enzyme that is absent in healthy colon tissue but abundant in colon cancer cells. The enzyme appears to drive the conversion of normal colon tissue into cancer by attaching sugar molecules, or glycans, to certain proteins in the cell.
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The multigenic nature of human tumors presents a fundamental challenge for cancer research. To capture this genetic complexity we generated multigenic models of colon cancer in Drosophila-double, triple and quadruple combinations of transgenes representing mutations found together in sequenced human colon tumors. We then investigated the tumorigenic and metastatic potential of each of these combinations by targeting them specifically to the adult Drosophila colon as it shows important similarities to the human colon in terms of the signaling pathways that regulate its maintenance. We focused our initial analysis on three quadruple combinations: 1) rasG12V p53RNAi apcRNAi ptenRNAi, 2) rasG12V p53RNAi apcRNAi Smad4RNAi and 3) egfr p53RNAi apcRNAi Smad4RNAi. These models recapitulated key features of human cancer, including proliferation and multilayering of the colon epithelium, evasion of apoptosis and a senescence-like process, epithelial-mesenchymal-transition (EMT), migration and dissemination ...
put him on his back, i said, oozing confidence, im going through the abdomen. they nodded. and did so. once everything was ready we all started scrubbing and the sister started draping the patient. i tried to envisage what i would be doing in a while. i decided that id reflect the right colon up and pull the ivc out of the way, rather than reflecting the left colon up, which would mean id have more to do with the aorta. my reason had little to do with the blood vessels but rather had to do with the fact that the right colon can be reflected right out of the way whereas the left colon cant because it continues down to the rectum which is pretty much fixed. truth be told, the aorta is easier to work with than the ivc, but i just felt id get more exposure on the right. in my mind i was just trying to convince myself that it was going to be fine when the great orthopaedic consultant entered. he greeted us all and thanked me for my help before quickly going into the theater to make sure ...
BACKGROUND: Colon cancer occurrence is increasing worldwide, making it the third most frequent cancer. Although many therapeutic options are available and quite efficient at the early stages, survival is strongly decreased when the disease has spread to other organs. The identification of molecular markers of colon cancer is likely to help understanding its course and, eventually, to uncover novel genes to be targeted by drugs. In this study, we compared gene expression in a set of 95 human colon cancer samples to that in 19 normal colon mucosae, focusing on 401 genes from 5 selected pathways (Apoptosis, Cancer, Cholesterol metabolism and lipoprotein signaling, Drug metabolism, Wnt/beta-catenin ...
Fingerprint Dive into the research topics of Gpr109a limits microbiota-induced IL-23 production to constrain ILC3-mediated colonic inflammation. Together they form a unique fingerprint. ...
Our colon can be a magnet of all the things that we eat-thats why it serves as a double edge. Why? IT may be of benefit if we live a nutritious lifestyle i.e. balanced diet, eating nutritious foods, etc… however, it can be very detrimental if we are the type of person who lives in a quick lifestyle-fast foods, canned goods, processed meat and the likes. This is where our colon can be both harmful and beneficial.
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Dr. Zadeh responded: Depends. The answer to this question really depends on the specific type of |a href=/topics/colonic track_data={
When beginning a detox, the first organ that needs to be addressed is the colon. The colon is the bodys number 1 elimination channel, and unless it is properly working, detoxifying other organs of the body will be nowhere near as beneficial-and in some cases, can even cause harm. This is because if you are detoxing with a sluggish colon, the toxins we are trying to remove from the body will have no way of exiting. They can then recirculate around the body, causing damage.. A backed-up, sluggish colon can be at the heart of many health problems. With bowel cancer making it into the top 3 most common cancers diagnosed each year in Australia, it is easy to see just how important bowel health is.. When faecal matter is backed up in the colon, it becomes toxic. Doing a colon detox (using my Colon Detox #1 AND Colon Detox #2) can help you to resolve problems that you never even imagined! Cleaning your colon has been known to help:. ...
During surgery, the cancer is removed following sound oncological principles. We remove a small length of healthy colon on either side of the cancer to ensure that no microscopic cancer cells are left behind.
Have you seen what happens to a plant when it is starved of water? Drink plenty of fresh clear fluids. Make sure that all aspects of your body are well hydrated with refreshing cleansing fluids by taking those fluids on a regular basis in their safest most natural form.. Water is the most important ingredient in your diet. Without enough water you will stress your system. Make sure your body doesnt go short so that the colon can work.. ...
Learn about all the various causes of swollen colon development and its symptoms. One of them actually bleeds a little and the blood looks like it may be slightly pus-y though im. A swollen colon can be caused by an infection, blood flow problems, disease, or chemicals in the colon.
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Barrio Balboa is one of the 18 corregimientos of La Chorrera District. The population is of 33,214 peoples, and its representative is Pedro A. Montero H.. "Archived copy". Archived from the original on 2014-05-30. Retrieved 2012-12-10.CS1 maint: archived copy as title (link) v t ...
Colom is a metro station of the Metrovalencia network in Valencia, Spain. It is situated on Carrer de Colom, in the southeastern part of the city centre. The station is an underground structure ...
T0: No evidence of cancer in the colon or rectum.. *Tis: Carcinoma in situ; Cancer cells are found only in the epithelium or ... Colon cancer staging is an estimate of the amount of penetration of a particular cancer. It is performed for diagnostic and ... M1b: Metastasis to more than 1 other part of the body beyond the colon, rectum or regional lymph nodes. Any T, any N. ... Turnbull RB Jr, Kyle K, Watson FR, et al: Cancer of the colon: the influence of the no touch isolation technique on survival ...
Colón (Spanish pronunciation: [koˈlon]) is a province of Panama. The capital is the city of Colón. It covers an area of 4,575.5 ... "Municipios (Distritos) de Colón". Editorial OX. Retrieved 15 November 2012.. *^ As at 1 July 2010; adjusted for under- ... Colón District Barrio Norte1, Barrio Sur1, Buena Vista, Cativá, Ciricito, Sabanitas, Salamanca, Limón, Nueva Providencia, ... Colón Province is divided into 5 distritos (districts) and subdivided into 40 corregimientos.[4] ...
Pages in category "People from Colón Department (Honduras)". The following 35 pages are in this category, out of 35 total. This ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Category:People_from_Colón_Department_(Honduras)&oldid=466122336" ...
Columbus Towers or Torres de Colón is a highrise office building composed of twin towers located at the Plaza de Colón in ... It is found in and dominates the Plaza de Colón, one of the major commercial centres in Madrid.[citation needed] The twin ... Content in this edit is translated from the existing Spanish Wikipedia article at [[:es:Torres de Colón]]; see its history for ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Torres_de_Colón&oldid=931529724" ...
"Teatro Colón. Archived from the original on 17 July 2007.. *^ "Official Schedule for October 2006". Teatro Colón. Archived from ... Historia del Teatro Colón, Vol I-III, Cinetea, Buenos Aires, 1969.. *Ferro, Valenti. Las voces del Teatro Colón, Buenos Aires, ... Las historias más insólitas del Teatro Colón. 2002. *Sessa, Aldo, Manuel Mujica Láinez, Vida y gloria del Teatro Colón. 1983. ... The first Teatro Colón[edit]. The first Teatro Colón was designed by Charles Pellegrini, and proved to be a successful venue ...
Inclusion of a diagram of the colon, labeling e.g. 'sigmoid colon', 'ascending colon', 'descending colon','transverse colon' ... The squatting theory is looking better and better, now that Burkitt's hunch about fiber has failed in the case of colon cancer ...
The Secret Life of Willie Colón) and the launching of his record label Willie Colon Presents.[13] For 2018 Colón kicked off his ... "LMEC Commissioner Willie Colon". Home2.nyc.gov. Retrieved May 3, 2010.. *^ Willie Colón Endorses Hillary Clinton for President ... Chávez addressed Colón via Twitter [19] ("shoemaker tend to your shoes"). After Chávez' death, Willie Colón endorsed opposition ... "Willie Colón - News Blog » Blog Archive » Freed Political Prisoner General Antonio Rivero Thanks Willie Colón - YouTube". ...
Sarcoma, Oral Cancer, Liver Cancer, and Colon Cancer[edit]. BHLHE41 has been shown to suppress the expression of vascular ... It has been shown that the normal tissue adjacent to colon carcinomas show high levels of BHLHE41 expression.[35] Research is ...
The colon is not a sterile environment; many bacteria that normally live in the colon ensure the well-functioning of the bowel ... The colon has distension sensors that can tell when there is unexpected gas pushing the colon walls out-thus the "second brain ... The endoscope is then passed through the anus up the rectum, the colon (sigmoid, descending, transverse and ascending colon, ... Colonoscopy reduces cancer rates by detecting some colon polyps and cancers on the left side of the colon early enough that ...
... is a municipality and a city in the northern Honduran department of Colón slightly inland at 38 m elevation in the ... There is a Rehabilitation Center (Centro de Rehabilitacion Integral de Colon - CRICOL ) which provides high - quality ... is one of the most populated cities in the northern part of Honduras and is the most populated city in the Department of Colón ... Retrieved from "https://en.wikipedia.org/w/index.php?title=Tocoa,_Colón&oldid=898833356" ...
2005). "Assessment of JC polyoma virus in colon neoplasms". Dis. Colon. Rectum. 48 (1): 86-91. doi:10.1007/s10350-004-0737-2. ... as JCV has been found in malignant colon tumors, but these findings are still controversial.[13] ...
Colon. *Ascending colon. *Hepatic flexure. *Transverse colon. *Splenic flexure. *Descending colon. *Sigmoid colon ...
... transverse colon and its mesocolon, and the diaphragm. The term was introduced around 1896 by Philip Polson of the Catholic ...
The company was formed by a merger between Britain's Reckitt & Colman plc and the Dutch company Benckiser NV in December 1999. Bart Becht became CEO of the new company and has been credited for its transformation, focusing on core brands and improving efficiency in the supply chain. The new management team's strategy of "innovation marketing".[20] - a combination of increased marketing spend and product innovation, focusing on consumer needs - has been linked to the company's ongoing success. For example, in 2008, the company's "rapid succession of well publicised new product variants" were credited for helping them "to capture shoppers' imagination".[21] Business Week has also noted that "40% of Reckitt Benckiser's $10.5 billion in 2007 revenues came from products launched within the previous three years."[22] In October 2005, RB agreed to purchase the over-the-counter drugs manufacturing business of Boots Group, Boots Healthcare International, for £1.9 billion. The three main brands acquired ...
Colon. *Ascending colon. *Hepatic flexure. *Transverse colon. *Splenic flexure. *Descending colon. *Sigmoid colon ...
colon. ፦ Preface colon (introduces speech from a descriptive prefix). ፧ question mark. ፨ paragraph separator. Grammar[edit]. ...
While the main purpose of the train is as a commuter rail for those living in Panama City and working in Colon, it has also ... The Corozal (Panama City)-Colón train leaves at 7:15 a.m., and the return train leaves at 5:15 p.m., with a traveling time of ... The route stretches 47.6 miles (76.6 km) across the Isthmus of Panama from Colón (Atlantic) to Balboa (Pacific, near Panama ... Starting in May 1850, what would become the city of Aspinwall (now Colón) was founded on 650 acres (260 ha) on the western end ...
Colon[edit]. The colon may be regarded as two organs, *the right side (cecum and ascending colon), a fermenter.[80] The right ... the left side (transverse, descending, and sigmoid colon), affecting continence.. The presence of bacteria in the colon ... Soluble fiber (fermentable fiber or prebiotic fiber) - which dissolves in water - is generally fermented in the colon into ... lower colonic pH (i.e., raises the acidity level in the colon) which protects the lining from formation of colonic polyps and ...
Colon Rectum. 50 (8): 1169-81. doi:10.1007/s10350-006-0842-5. PMID 17347903. Gassler N, Herr I, Keith M, Autschbach F, Schmitz- ... 5-aminosalicylate (ASA) has been shown to reduce β-catenin and its localization to the nucleus in colon cancer cells isolated ... "Adjuvant immunochemotherapy with protein-bound polysaccharide K for colon cancer in relation to oncogenic β-catenin activation ...
... of colon cancers.[46] miR-34a is also generally under-expressed in primary neuroblastoma tumors.[47] ... "Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer ...
Colon/rectum. *colorectal polyp: Peutz-Jeghers syndrome. *Juvenile polyposis syndrome. *Familial adenomatous polyposis/ ...
Colon/rectum. *colorectal polyp: Peutz-Jeghers syndrome. *Juvenile polyposis syndrome. *Familial adenomatous polyposis/ ...
"Los Angeles Colon and Rectal Surgical Associates. 2012.. [unreliable source?] *^ Dal Monte PP, Tagariello C, Sarago M, et al. ( ... Colon Rectum. 53 (5): 803-11. doi:10.1007/DCR.0b013e3181cdafa7. PMID 20389215.. ... Colon Rectum. 52 (9): 1665-71. doi:10.1007/DCR.0b013e3181af50f4. PMID 19690499.. ...
Colon/rectum. *colorectal polyp: Peutz-Jeghers syndrome. *Juvenile polyposis syndrome. *Familial adenomatous polyposis/ ...
Colon, Jorge. "A Call for a Response From The International Chemistry Community. (Science For Haiti)." Chemistry International ... Machlis, Gary E, Jorge Colón, and Jean E. McKendry. Science for Haiti: A Report on Advancing Haitian Science and Science ...
New Jersey was once one of the most reliably Republican states in the Northeast. From 1948 to 1988, it voted Republican in all but two elections: John F. Kennedy in his narrow victory over Richard Nixon in 1960, and Lyndon Johnson's 44-state landslide of 1964. However, the brand of Republicanism practiced in New Jersey has historically been a moderate one. As the national party tilted more to the right, the state's voters became more friendly to Democrats. The state narrowly went for Bill Clinton in 1992 and has voted Democratic in every election since then. In all but one election since 1996, the Democrats have carried it by double digits. While Republicans remain competitive at the state and local level, at the presidential level New Jersey is now reckoned as part of the solid bloc of blue states in the Northeast. Democrats have several structural advantages in New Jersey during presidential elections. The northeastern portion, including Newark, Jersey City, Elizabeth and Paterson, contains ...
... transverse colon, spleen, adrenal gland, or kidney. Very often they also spread to the important blood or lymphatic vessels and ... hereditary non-polyposis colon cancer (Lynch syndrome); and familial adenomatous polyposis. PanNETs have been associated with ... if the cancer is invading or compressing the duodenum or colon. In such cases, bypass surgery might overcome the obstruction ...
Colon/rectum. *colorectal polyp: Peutz-Jeghers syndrome. *Juvenile polyposis syndrome. *Familial adenomatous polyposis/ ...
How to take care of your Colon health? Consult Aloe Expert... ... The most deathly disease shared among men and women-Colon ... colon cancer symptoms , How to Recognize Colon Cancer Symptoms-Healthy Wealthy - Duration: 2:10. Healthy Wealthy 88,298 views ... Doctors Are In A Shock This Kills 93% Of Colon Cancer In Just 2 Days , Life well lived - Duration: 3:41. Life Well Lived 86,750 ... 5 Symptoms Of Colon Cancer You Should Not Ignore - Duration: 4:29. Remedies For You 1,756,898 views ...
A polyp is a projection (growth) of tissue from the inner lining of the colon into the lumen (hollow center) of the colon. ... Colon Polyps (Sessile or Traditional Serrated Adenomas). Polyps that tend to grow as slightly flattened, broad-based polyps are ... Colon Pathology. These questions and answers are meant to help you understand the medical language used in the pathology report ... Invasive Adenocarcinoma of the Colon. Adenocarcinoma is a type of cancer that starts in the cells that form glands making mucus ...
T0: No evidence of cancer in the colon or rectum.. *Tis: Carcinoma in situ; Cancer cells are found only in the epithelium or ... Colon cancer staging is an estimate of the amount of penetration of a particular cancer. It is performed for diagnostic and ... M1b: Metastasis to more than 1 other part of the body beyond the colon, rectum or regional lymph nodes. Any T, any N. ... Turnbull RB Jr, Kyle K, Watson FR, et al: Cancer of the colon: the influence of the no touch isolation technique on survival ...
We rely on advertising to help fund our award-winning journalism.. We urge you to turn off your ad blocker for The Telegraph website so that you can continue to access our quality content in the future.. Thank you for your support.. ...
Durante el proceso, explicó, se examina el colon y el recto con un colonoscopio, un tubo delgado y flexible que tiene una ... A woman who competed on "Jeopardy!" while battling terminal colon cancer has died the week before her episode was set to air ... Former IndyCar and NASCAR driver John Andretti says he is undergoing chemotherapy for stage-four colon cancer thats spread to ... The World Health Organization recently released a report linking bacon and other processed meat to colon cancer. ...
Pseudodiverticulosis Diverticulosis of the colon is characterized by diverticula in the colon. They represent herniations of ... Diverticulosis of the colon is characterized by diverticula in the colon. They represent herniations of the colonic mucosa and ... Diseases of the Colon and Rectum, 54, 1326-1338.CrossRefPubMedGoogle Scholar ... Golder, M., Ster, I. C., Babu, P., Sharma, A., Bayat, M., & Farah, A. (2011). Demographic determinants of risk, colon ...
... colon cleanse diet tea, diet food to lose weight fast plan, low carb diet foods to avoid, easy healthy recipes with chicken, ... Colon Cleanse Pro brought to you by the National Diet Team is a natural yet highly effective colon cleanser that can prepare ... Comments to "Colon cleanse diet tea". * NFS_Carbon. : 18.12.2009 at 21:16:53 Sunflower seeds are loaded with protein almond ... Colon cleanse is an excellent way to help relieve bloating and constipation and it may also help to improve energy and weight ...
Going to colon by Ship. The quote of $35 for taxi. Is that in US dollars?? Are there admission fees for the zoo and other ... Travel from Panama City to Colon 30 November 2017 * Location of the last stop for the train from Colon to Panama 20 November ... When you get to Colon, look for the green SET taxis (Servicio Especial de Turismo). The drivers speak English and most have a ... going to colon by Ship. The quote of $35 for taxi. Is that in US dollars?? ...
COLON.* The PUNCTUATION [1] mark (:). It has an anticipatory effect, leading from what precedes to what follows. The following ... co·lon1 / ˈkōlən/ • n. a punctuation mark (:) indicating: ∎ that a writer is introducing a quotation or a list of items. ∎ that ... Home Literature and the Arts Language, Linguistics, and Literary Terms Language and Linguistics Colon (grammar) ... COLON. The PUNCTUATION mark (:). It has an anticipatory effect, leading from what precedes to what follows. The following are ...
Visitors can walk through the inflatable colon to see cancer cells and polyps up close. (March 22) ... 10-foot high replica of the human colon was on display Friday in Miami to educate people about colorectal cancer. ... A 30-foot long, 10-foot high replica of the human colon was on display Friday in Miami to educate people about colorectal ... Visitors can walk through the inflatable colon to see cancer cells and polyps up close. (March 22) AP ...
Colon Cancer Screening. English Español Polskie 中文 PDF Is colon cancer screening available through the World Trade Center ... What is the risk from colon cancer screening?. Some procedures used to examine the colon do present minimal risk, but for most ... When am I eligible for colon cancer screening?. Colon cancer screening is recommended to begin at the age of 50, and should ... What are the benefits of colon cancer screening?. Colon cancer screening looks for cancer before you feel symptoms from the ...
Colón (Spanish pronunciation: [koˈlon]) is a province of Panama. The capital is the city of Colón. It covers an area of 4,575.5 ... "Municipios (Distritos) de Colón". Editorial OX. Retrieved 15 November 2012.. *^ As at 1 July 2010; adjusted for under- ... Colón District Barrio Norte1, Barrio Sur1, Buena Vista, Cativá, Ciricito, Sabanitas, Salamanca, Limón, Nueva Providencia, ... Colón Province is divided into 5 distritos (districts) and subdivided into 40 corregimientos.[4] ...
Militza Carrero-Colon Crop Production and Pest Control Research Biological Science Technician. Phone: (765) 494-8088 Fax: (765 ... Thapa, R., Carrero-Colon, M., Crowe, M.D., Gaskin, E.L., Hudson, K.A. 2015. Novel FAD2-1A alleles confer an elevated oleic acid ... Carrero-Colon, M., Abshire, N., Sweeney, D., Gaskin, E., Hudson, K.A. 2014. Mutations in SACPD-C result in a range of elevated ... Thapa, R., Carrero-Colon, M., Hudson, K.A. 2016. New alleles of FATB-1A to reduce palmitic acid levels in soybean. Crop Science ...
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Colon Cancer. There are no trials in this category at this time. ...
Dr Alok Khorana reports on a study indicating that increased milk and calcium intake is associated with improved outcomes after diagnosis of colorectal cancer.
Human Colon, Removed Feb 2010, Condition Ulcerative Colitis.JPG 3,456 × 2,592; 3.6 MB. ... Media in category "Human colon". The following 33 files are in this category, out of 33 total. ... That was my wife colon she was oprated on 31st march 2010.jpg 320 × 240; 12 KB. ... Retrieved from "https://commons.wikimedia.org/w/index.php?title=Category:Human_colon&oldid=274491727" ...
Get a complete listing of Car Dealerships in Colon, Nebraska and make the process of buying your next new car, truck, or SUV ... Find Colon, Nebraska Car Dealerships. Visit Edmunds.com for a complete listing of local car dealerships in Colon, Nebraska. ... With the ability to compare prices on new and used vehicles in Colon, Edmunds.com makes the car buying process convenient and ... Search for car dealerships in Colon, Nebraska with our comprehensive dealership network and avoid the common hassles associated ...
Colon cancer can be treated and cured if its diagnosed early, and a colonoscopy is one of the best ways to detect the disease ... March is National Colon Cancer Awareness Month. Colon cancer is the second leading cause of cancer death in the United States. ... Colon Cancer: Symptoms, Signs, Screening, Stages. Colorectal cancer (colon cancer) is the cause of many cancer deaths. Learn ... Gutkin noted that women and men have the same risk for colon cancer, and that having no risk factors does not mean you wont ...
See an archive of all colon cancer stories published on the New York Media network, which includes NYMag, The Cut, Vulture, and ... You Could Have Walked Through a Huge Colon in Grand Central Today. For a good cause. ...
Rafael Hernández Colón (born 1936), Puerto Rican political leader and ,twice-elected governor, was one of the foremost ... Rafael Hernández Colón. Rafael Hernández Colón (born 1936), Puerto Rican political leader and twice-elected governor, was one ... Rafael Hernández Colón was born on October 24, 1936, in Ponce, Puerto Rico, the son of Rafael Hernández Matos, a lawyer who ... Rafael Hernández Colón (räfäĕl´ ĕrnän´dĕs kōlōn´), 1936-, governor of Puerto Rico (1973-77, 1985-93). An honors graduate of ...
Visit Ralph colons CaringBridge website where youll find the latest updates and a place to share messages of love, hope & ...
Visit Paula Colons CaringBridge website where youll find the latest updates and a place to share messages of love, hope & ... Paula Colon Master Electricians University Place provides 24 hours a day, 7 days a week electric service to ensure your ...
Yes, I would like to receive e-mail from Colon Cancer Challenge Foundation. ... Yes, I would like to receive postal mail from Colon Cancer Challenge Foundation. ...
... Colon Cancer Self Screening Test ( ...
Flushing your colon with herbs to eliminate toxins may appeal to some, but the road to wellness does not pass through the ... They say colon cleansing can help restore balance in the body.. Colon cleansing has been around since ancient times, when the ... Sometimes called colonic irrigation or colonic hydrotherapy, colon cleansing often involves flushing the colon with a mixture ... Colon cleansing can supposedly help you lose weight, eliminate toxins and enhance well-being. But a review of scientific ...
... checks on pitcher Bartolo Colon, who was eventually taken out of the game in the second inning. ... Angel manager Mike Scioscia, left, checks on pitcher Bartolo Colon, who was eventually taken out of the game in the second ... Angel manager Mike Scioscia, left, checks on pitcher Bartolo Colon, who was eventually taken out of the game in the second ... Angel manager Mike Scioscia, left, checks on pitcher Bartolo Colon, who was eventually taken out of the game in the second ...
Which classes of medications are most commonly associated with drug-induced colon ischemia, and what are their respective ... Pharmacologic Agents Strongly Associated With Colon Ischaemia. *Pharmacologic Agents Moderately Associated With Colon Ischaemia ... Pharmacologic Agents Strongly Associated With Colon Ischaemia. *Pharmacologic Agents Moderately Associated With Colon Ischaemia ... Background: Colon ischaemia is the most common ischaemic disorder of the gastrointestinal system, can affect any segment of the ...
Download this Colon Organ Anatomy photo now. And search more of the webs best library of royalty-free stock images from iStock ... Colon organ anatomy - Stock image. .... Abdomen, Anatomy, Ascending Colon, Biomedical Illustration, Blue. ...
  • Adenocarcinoma is a type of cancer that starts in the cells that form glands making mucus to lubricate the inside of the colon and rectum. (cancer.org)
  • T0: No evidence of cancer in the colon or rectum. (wikipedia.org)
  • T3: Growth through the muscularis propria and into the subserosa, or into tissues surrounding the colon or rectum (but not the visceral peritoneum or surrounding organs). (wikipedia.org)
  • M1a: Spread to 1 other part of the body beyond the colon, rectum or regional lymph nodes. (wikipedia.org)
  • Diseases of the Colon and Rectum, 54 , 1326-1338. (springer.com)
  • Sometimes called colonic irrigation or colonic hydrotherapy, colon cleansing often involves flushing the colon with a mixture of herbs and water through a tube inserted in the rectum. (newscientist.com)
  • Colorectal cancer is a result of cancer cells that form in the lining of the colon (large intestine) or rectum. (medicinenet.com)
  • Adenomas are a type of polyp and are benign tumors of the tissue lining the colon or rectum. (medicinenet.com)
  • A colonoscopy allows examination of the entire colon and rectum using a tiny camera. (medicinenet.com)
  • An X-ray of the colon, known as a lower GI series, can provide another way to image the colon and rectum. (medicinenet.com)
  • If there are abnormalities seen in your colon or rectum, a biopsy is done to determine whether cancer is present. (medicinenet.com)
  • Stage 0 - The cancer is found only in the innermost lining of the rectum or colon. (medicinenet.com)
  • Stage I - The cancer has not spread beyond the inner wall of the rectum or colon. (medicinenet.com)
  • Stage II - The cancer has spread into the muscle layer of the rectum or colon. (medicinenet.com)
  • But if the cancer has had a chance to spread outside the colon or rectum, survival rates are lower. (cancer.org)
  • If cancer is detected in your colon or rectum, a colostomy is performed. (cancercare.org)
  • Colon cancer, also referred to as colorectal cancer or large bowel cancer involves cancerous growths in the colon, rectum and appendix. (buzzle.com)
  • Colorectal cancer refers the cancer of the large intestine (colon) or the rectum. (buzzle.com)
  • Inherited conditions such as familial adenomatous polyposis and Gardner's syndrome can cause hundreds of polyps to grow in the colon and rectum. (womenshealthmag.com)
  • Sigmoidoscopy - A thin, lighted tube fitted with a video camera is inserted into the colon through the rectum, allowing the doctor to examine the area for polyps. (womenshealthmag.com)
  • Barium enema - Chalky liquid is injected into the colon through the rectum, and then X-ray images are taken of the intestine. (womenshealthmag.com)
  • Some are using do-it-yourself colon cleansing methods - such as laxatives, enemas or herbal remedies - while others are undergoing colonic irrigation (also known as colonic hydrotherapy, or colonics) and allowing gallons of water to be flushed through a tube into their rectum, to purportedly remove harmful toxins and eliminate old fecal material from their bodies. (livescience.com)
  • Colorectal cancer starts either in your colon or your rectum, both of which are parts of the large intestine. (aarp.org)
  • Most of these cancers start out as polyps, or growths on the inner lining of your colon or rectum. (aarp.org)
  • If cancer forms in a polyp, it grows into the wall of the colon or rectum. (aarp.org)
  • Abnormal mushroom growths usually start in the inner surface of the colon or rectum and some eventually become malignant tumors, while others remain as benign polyps. (brighthub.com)
  • During defecation, the descending colon helps to propel feces toward the sigmoid colon and rectum and eventually out of the body by contraction of its smooth muscle tissue. (innerbody.com)
  • For a flexible sigmoidoscopy , a trained medical professional uses a sigmoidoscope -a flexible, narrow tube with a light and tiny camera on one end-to look inside your rectum and lower colon. (nih.gov)
  • Virtual colonoscopy uses x-rays and a computer to create images of your rectum and colon from outside the body. (nih.gov)
  • Together, the colon and rectum make up the large intestine. (hopkinsmedicine.org)
  • Brcic I. (2017) Diverticular Disease, Colon. (springer.com)
  • WEDNESDAY, March 22, 2017 (HealthDay News) -- Colon cancer can be treated and cured if it's diagnosed early, and a colonoscopy is one of the best ways to detect the disease, a gastroenterologist says. (medicinenet.com)
  • Bartolo Colon just went from being one of Major League Baseball's worst players in 2017 to Minor League Baseball's best marketing tool. (nydailynews.com)
  • My 45 yr old son in law passed away last year after fighting colon cancer and spread to liver and lungs at diagnoses for 8 years. (cancerresearchuk.org)
  • Our 2018 property listings offer a large selection of 12 vacation rentals near Colon. (vrbo.com)
  • Recent study: Office desk job doubles colon cancer risk Study participants who spent 10 or more years working at a desk had almost twice the risk of distal -- descending -- colon cancer and a 44 percent increased risk of rectal -- the final portion of the large intestine -- cancer. (angelfire.com)
  • The colon is the main portion of the large intestine and is divided into four regions: the ascending, transverse, descending, and sigmoid colon. (innerbody.com)
  • colon cancer, cancer of any part of the colon (often called the large intestine ). (factmonster.com)
  • Colon cancer develops when tumorous growths develop in the large intestine. (medicalnewstoday.com)
  • The colon, or large intestine, is where the body draws out water and salt from solid wastes. (medicalnewstoday.com)
  • In the U.S., cleansing the colon -- the large intestine -- became popular in the early 1900s. (webmd.com)
  • Colon cancer refers to the growth of cancerous cells in the colon (large intestine). (buzzle.com)
  • Colon polyps are growths of tissue inside the large intestine, also called the colon. (womenshealthmag.com)
  • Colon cancer is an abnormal, disorderly, and uncontrollable growth of cells in the large intestine, where the body's waste material is stored. (brighthub.com)
  • The descending colon is a segment of the large intestine and is the third and penultimate segment of the colon. (innerbody.com)
  • A 30-foot long, 10-foot high replica of the human colon was on display Friday in Miami to educate people about colorectal cancer. (usatoday.com)
  • Colorectal cancer (colon cancer) is the cause of many cancer deaths. (medicinenet.com)
  • Colorectal cancer , which describes co-occurring colon cancer and rectal cancer, is also common. (medicalnewstoday.com)
  • Stage 4 colon cancer, or what is also known as colorectal cancer, is the last stage of one going through the effects of this disease. (buzzle.com)
  • In this article, you will find causes, symptoms and treatment methods for colon or colorectal cancer in men. (buzzle.com)
  • Colon cancer, which is also referred to as colorectal cancer, occurs due to uncontrolled and abnormal cell division in the colon. (buzzle.com)
  • These are the different DNA genetics in colon cancer which are responsible for developing certain diseases that when gone unmanaged may develop into colorectal cancer. (brighthub.com)
  • He or she may also ask if you have a family history of colon polyps or colorectal cancer . (nih.gov)
  • Angel manager Mike Scioscia, left, checks on pitcher Bartolo Colon, who was eventually taken out of the game in the second inning. (latimes.com)
  • Bartolo Colon has always admired Hall of Fame pitcher and fellow countryman Juan Marichal. (nydailynews.com)
  • Bartolo Colon nearly made history Sunday night. (nydailynews.com)
  • Bartolo Colon is not coming back. (nydailynews.com)
  • The Mets have reached out to Bartolo Colon about a possible reunion, but are not expected to come to an agreement Thursday. (nydailynews.com)
  • In a way, Bartolo Colon never really left. (nydailynews.com)
  • Bartolo Colon may no longer be with the Mets, but he still has an influence on their young pitchers. (nydailynews.com)
  • Bartolo Colon is preparing for his 20th MLB season and the first of his post-Mets career by getting his blood flowing. (nydailynews.com)
  • Angels starter Bartolo Colon will take the mound Wednesday against Boston right-hander and countryman Pedro Martinez in what could be the most anticipated postseason game in the Dominican Republic. (mlb.com)
  • Bartolo Colon points as he retires Seattle's Yuniesky Betancourt with two runners in scoring position for the third out of the 7th inning during Sox 2-1 win. (dailypress.com)
  • Statistically, a family history of colon cancer or cancer of the female reproductive organs, a history of colon polyps, or a history of ulcerative colitis puts one at a greater risk of developing colon cancer. (factmonster.com)
  • On average, the lifetime risk of developing colon cancer is about one in 20. (cnbc.com)
  • The fact that Colon pitched in the ALDS in 1998, 1999, and 2001 while with Cleveland doesn't hurt, either. (mlb.com)
  • Colón a débuté en 1999 , il luttait dans la Cruiserweight division. (wikipedia.org)
  • The Colon Cancer Alliance was founded in 1999 by a group of 41 survivors, caregivers and friends who saw the need to educate the public about colon cancer and provide support to those affected by the disease. (cnbc.com)
  • Extra fat, especially around the waist alters your metabolism and increases your chances of developing colon and rectal cancer. (womenshealthmag.com)
  • In 2020, there were an estimated 104,610 new cases of colon cancer and 43,340 cases of rectal cancer diagnosed in the United States, and almost 90 percent of those cases were diagnosed in adults age 50 and older. (aarp.org)
  • Reader: I wish to pay tribute to Dr. David Prager, who was instrumental in joining me to create a multidisciplinary board to evaluate and make recommendations for treatment of all colon and rectal cancer. (mcall.com)
  • Today, colonic hygienists or colon hydrotherapists perform colon irrigations. (webmd.com)
  • After preliminary studies, scientists conclude that it might cause colonic inflammation and promote colon cancer. (medicalnewstoday.com)
  • After completion of the railway in 1855, Colón overshadowed the older Caribbean ports of Panama, and with the first plans for the isthmian canal it took on additional prestige . (britannica.com)
  • Eddie Carlos Colón ( San Juan , 21 december 1982 ), beter bekend als Primo , is een Puerto Ricaans professioneel worstelaar die werkzaam is bij de WWE als Diego en vormt samen met zijn neef, Orlando Colón (Fernando), een tag team , Los Matadores . (wikipedia.org)
  • Talk to your doc about earlier testing if you have a history of colon polyps, cancer, or other colon diseases. (menshealth.com)
  • Le 26 janvier 2008, Colón a fait ses débuts à la Florida Championship Wrestling , battant Shawn Osbourne. (wikipedia.org)
  • Edwin Carlos Colón (né le 21 décembre 1982 à San Juan , Porto Rico ) est un catcheur américano - portoricain . (wikipedia.org)
  • NEW YORK (Reuters Health) - Cigarette smoking appears to promote the development of polyps in the colon, especially those that are more likely to progress to cancer, a research review suggests. (reuters.com)
  • These are age, polyps in the colon, diet and lifestyle, chronic inflammatory bowel disease, and familial or genetic history. (brighthub.com)
  • Some of the symptoms of colon cancer are blood in stool and change in bowel habits. (buzzle.com)
  • Symptoms of colon cancer, if identified at an early stage, can help in treating the condition completely. (buzzle.com)
  • Most symptoms of colon cancer are nonspecific: You might have a tummy ache or lose your appetite or feel bloated. (aarp.org)
  • The danger from polyps is that most cases of colon cancer spring from these growths. (womenshealthmag.com)
  • Hij heeft een broer, Carlos Colón Jr. ( Carlito ) en een zus, Stacy Colón, die beiden ook actief zijn in het worstelen. (wikipedia.org)
  • Il est le fils de Carlos Colón Sr., le frère de Carlito et le cousin de Epico . (wikipedia.org)
  • Occasionnellement, il lutte dans des matches en équipe avec Carlito pour le World Wrestling Council. (wikipedia.org)
  • Le 25 août, pour son premier match à Raw , il bat Charlie Haas déguisé en Carlito , avec un saut de l'ange du haut de la troisième corde. (wikipedia.org)
  • Le 12 septembre, il apparaît à SmackDown en compagnie de son frère Carlito , ils défont les champions par équipe, Les Ex-Edgeheads ( Curt Hawkins et Zack Ryder ), dans un match sans enjeu. (wikipedia.org)
  • March is National Colon Cancer Awareness Month. (medicinenet.com)
  • WASHINGTON,, Feb. 16, 2016 (GLOBE NEWSWIRE) -- In 2000, March was officially dedicated as National Colon Cancer Awareness Month. (cnbc.com)
  • The nation's oldest and largest nonprofit dedicated to the disease, the Colon Cancer Alliance, is encouraging everyone to support National Colon Cancer Awareness Month so the disease can be knocked out of the top three cancer killers. (cnbc.com)
  • National Colon Cancer Awareness Month provides the Colon Cancer Alliance a greater opportunity to create a dialogue about this deadly disease and decrease the barriers to screening," said Michael Sapienza, CEO of the Colon Cancer Alliance. (cnbc.com)
  • Support National Colon Cancer Awareness Month. (cnbc.com)
  • Il a gagné son premier titre le 10 février 2001, en battant Damian Steele pour le WWC World Junior Heavyweight Championship. (wikipedia.org)
  • Cleansing and detoxifying the body helps to clear the body of any unwanted toxins in the colon and thus prepare our body for our weight loss journey. (amazonaws.com)
  • Colon cleansing can supposedly help you lose weight, eliminate toxins and enhance well-being. (newscientist.com)
  • Proponents of colon cleansing, however, believe that toxins in your gastrointestinal tract can cause a variety of health problems, such as arthritis, allergies and asthma. (newscientist.com)
  • Colon cleansing has been around since ancient times, when the procedure was thought to help the body dispose of waste and toxins. (newscientist.com)
  • Colon cleansing is a method to remove harmful toxins from the body. (buzzle.com)
  • A colon cleansing diet menu plan, that will help you cleanse your system of impurities and toxins, is what you will find here. (buzzle.com)
  • When followed with correct steps and precautions, a natural colon cleanse remedy is effective to flush body toxins, without causing side effects. (buzzle.com)
  • Colon cleansing is an effective way to flush out the toxins accumulated in the body. (buzzle.com)
  • Cleansing enthusiasts suggest that old stool can stick to the colon walls and harden, causing the release of toxins that can lead to a wide array of health problems, from bloating and fatigue to depression and achy joints. (livescience.com)
  • This cell turnover means stool doesn't stick to intestinal walls, and so-called toxins don't build up in the colon and get released into the bloodstream, as cleansing proponents contend. (livescience.com)
  • Stool in the blood, diarrhea, constipation and abdominal cramps, are some of the common symptoms of sigmoid colon cancer. (buzzle.com)
  • It transports feces from the transverse colon inferiorly along the left side of the abdominal cavity to the sigmoid colon. (innerbody.com)
  • From the splenic flexure, the descending colon extends inferiorly toward the left hip before turning about 90 degrees to the right and forming the sigmoid colon. (innerbody.com)
  • During defecation, these muscle cells contract in waves of peristalsis to push feces down the colon toward the sigmoid colon. (innerbody.com)
  • The transverse colon is the longest region of the colon and is located between the ascending colon and descending colon. (innerbody.com)
  • Much of the absorption and feces formation of the colon takes place in the transverse colon, making it a very important region of the digestive system. (innerbody.com)
  • The transverse colon begins at the hepatic flexure, a sharp bend at the superior end of the ascending colon just inferior to the liver on the right side of the abdominal cavity. (innerbody.com)
  • At the hepatic flexure, the colon turns to the left and crosses to the left side of the abdominal cavity as the transverse colon. (innerbody.com)
  • The transverse colon is a hollow tube about 2.5 inches (6 cm) in diameter and around 18 inches (46 cm) in length. (innerbody.com)
  • It curves along its length so that the middle of the transverse colon is inferior and posterior to the hepatic and splenic flexures at its ends. (innerbody.com)
  • Many pouches, or haustra, are formed in the walls of the transverse colon by contraction of the smooth muscle of the intestinal walls. (innerbody.com)
  • The walls of the transverse colon are made of four tissue layers: the mucosa, submucosa, muscularis, and serosa. (innerbody.com)
  • Its name is derived from the mucus produced by goblet cells that line the surface of the mucosa to lubricate the transverse colon. (innerbody.com)
  • The next layer, the muscularis, is made of several bands of smooth muscle that mix and move feces through the transverse colon. (innerbody.com)
  • Lastly, the serosa is the outermost layer of the transverse colon that acts as the skin of the colon. (innerbody.com)
  • Just like the skin of our arms protects what is beneath it, the serosa protects the transverse colon from damage caused by its surroundings. (innerbody.com)
  • The serosa secretes serous fluid, a thin, slick secretion that prevents friction between the transverse colon and the surrounding tissues. (innerbody.com)
  • The transverse colon mixes feces by contracting small regions of the intestinal wall in a process known as segmentation. (innerbody.com)
  • At its superior end, the descending colon connects to the transverse colon at the splenic flexure just inferior to the spleen. (innerbody.com)
  • By the time feces reach the descending colon, the vast majority of nutrients, vitamins and water have been extracted by the ascending and transverse colon, leaving mostly waste products. (innerbody.com)
  • Colon cancer is also the third most common cause of cancer-related death in the U.S. In fact, in 2019, the American Cancer Society (ACS) predict that 101,420 people in the U.S. will receive a new diagnosis of colon cancer. (medicalnewstoday.com)
  • Travelocity-listed hotels that are close to the city center of Colon include the Radisson Colon 2,000 Hotel & Casino and Four Points By Sheraton Colon . (travelocity.com)
  • Diverticulosis of the colon is characterized by diverticula in the colon. (springer.com)
  • Treatment of complicated diverticulitis and diverticular bleeding may involve surgical removal of the segment of colon containing the diverticula. (medlineplus.gov)
  • Search for car dealerships in Colon, Nebraska with our comprehensive dealership network and avoid the common hassles associated with car shopping. (edmunds.com)
  • A PubMed search for "colon ischaemia" and "ischaemic colitis" alone as well as in combination with various known pharmacologic causes was performed. (medscape.com)
  • This photo shows an example of an "apple core" tumor that narrows the colon. (medicinenet.com)
  • Immunohistochemistry using antihuman p53 (Dako, Carpinteria, CA, USA) and antihuman p21 (Dako, Glostrup, Denmark) antibodies showed that p53 and p21 proteins tended to coexpress in the colon tumor cells (Fig. 3). (issuu.com)
  • In all mouse models used, triclosan prompted inflammation of the colon, worsened symptoms of colitis (inflammation of the lining of the colon), and promoted colitis-associated tumor growth. (medicalnewstoday.com)
  • The standard of care for colon cancer is surgery to remove the tumor, plus chemotherapy and radiation, if needed. (aarp.org)
  • Once a polyp develops into a tumor, it grows very fast and it can immediately block, invade, break through the colon walls then spread through other parts of the body. (brighthub.com)
  • The test, being developed by Danish biotech company Exiqon, worked well at both identifying colon cancers and at ruling them out, the company said at an American Association for Cancer Research meeting in Denver. (reuters.com)
  • Colon polyps typically emerge after age 50, and the large majority of colon cancers develop after this age as well. (reuters.com)
  • Celecoxib inhibits an enzyme called cyclooxygenase 2, which has been associated with various cancers in addition to colon cancer. (news-medical.net)
  • Colon and rectal surgeries are typically performed to treat colon and rectal cancers, inflammatory bowel disease (IBD), or diverticulitis, and may also be necessary following an injury or wound, serious infection, or bowel blockage. (hopkinsmedicine.org)
  • Water, nutrients, and vitamins are absorbed through the walls of the colon to be used by the tissues of the body. (innerbody.com)
  • Stage 1 colon cancer is when the cancer has not spread beyond the walls of the colon. (buzzle.com)
  • A polyp is a projection (growth) of tissue from the inner lining of the colon into the lumen (hollow center) of the colon. (cancer.org)
  • That resulted in a huge bowel obstruction from the gut full of scar tissue I developed, and the removal of nearly 2 feet of colon. (medhelp.org)
  • Immunostaining for p53 and p21 in primary colon cancer tissue. (issuu.com)
  • Like all parts of the gastrointestinal tract, the descending colon consists of four major tissue layers surrounding a hollow lumen. (innerbody.com)
  • on the posterior of the descending colon, the outermost layer is areolar connective tissue (known as adventitia). (innerbody.com)
  • Former IndyCar and NASCAR driver John Andretti says he is undergoing chemotherapy for stage-four colon cancer that's spread to his liver. (orlandosentinel.com)
  • The most common options for colon cancer are surgery, chemotherapy , and radiation therapy . (medicalnewstoday.com)
  • The following Buzzle article gives you an overview of chemotherapy and some of its possible side effects, when it is used for treating colon cancer. (buzzle.com)
  • The practice of natural colon cleansing dates back to ancient Greece. (webmd.com)
  • Colon cleansing as a practice is getting popular these days with increasing number of people looking out for commercial colon cleansers that work. (buzzle.com)
  • U.S. health experts recommend regular colonoscopies for people starting at age 50 and the practice is credited with helping to lower the number of deaths from colon cancer from around 52,000 in 2007 to just under 50,000 people in 2009 in the United States. (reuters.com)
  • In 2011, Mishori published a paper in The Journal of Family Practice, warning physicians about the possible side effects of colon cleansing , after she observed these dangers in two patients at her hospital and reviewed other case reports in the scientific literature. (livescience.com)
  • Rafael Hernández Colón was born on October 24, 1936, in Ponce, Puerto Rico , the son of Rafael Hernández Matos, a lawyer who served as an associate justice of the Supreme Court of Puerto Rico , and Dorinda Colón Clavell. (encyclopedia.com)
  • Colón entre ensuite dans une feud avec El Diamante pour le WWC Puerto Rico Heavyweight Championship. (wikipedia.org)
  • It contains many small pouches, known as haustra, along its length that increase its surface area and help to move feces through the colon. (innerbody.com)
  • Katie Becker Colón is an actress, known for Dead Billy (2016) and Imagining Vera (2014). (imdb.com)
  • As it stands, adults are advised to start colon cancer screening at the age of 50, though people at higher-than-average risk -- such as those with ulcerative colitis, or a family history of colon cancer -- often start earlier. (reuters.com)
  • This is the belief that undigested meat and other foods cause mucus buildup in the colon. (webmd.com)
  • Mucus membranes in the colon may keep unwanted substances from reentering the blood and tissues. (webmd.com)
  • The mucus secreted from goblet cells in the mucosa layer provides lubrication to feces moving through the lumen, protecting the delicate tissues of the colon. (innerbody.com)
  • The cancer has reached other tissues beyond the wall of the colon. (medicalnewstoday.com)
  • Therefore, she's not sure how cleansing the colon could enhance the production of the intricate components of the immune system, which includes white blood cells, proteins such as antibodies, and tissues and organs. (livescience.com)
  • Most are noncancerous (benign), but one type, the adenomatous polyp, is associated with changes (called mutations) in the DNA of the lining of the colon. (womenshealthmag.com)
  • Colon adenocarcinoma is the most widely diagnosed gastrointestinal cancer, that primarily affects men and women over 50 years of age. (buzzle.com)
  • A 72year-old man diagnosed with adenocarcinoma of the ascending colon and 14 bilateral liver metastases underwent a right hemicolectomy combined with microwave ablation of six metastatic liver tumors. (issuu.com)
  • Case Report A 72-year old man was diagnosed with well-differentiated adenocarcinoma of the ascending colon, 6 ⫻ 3 cm in size, with multiple liver metastases. (issuu.com)
  • Histological examination confirmed well-differentiated adenocarcinoma of the colon, Dukes' D with N1 lymph node invasion. (issuu.com)
  • This province has traditionally been focused in commerce (through the Colón Free Zone , Panama Canal and its banking activities), but also has natural resources that are being developed as tourist attraction, such as coral reefs and rainforests . (wikipedia.org)
  • The great portworks and docks built by the U.S. government in the former Canal Zone at Cristóbal, now essentially a suburb, make Colón one of the most important ports of the Caribbean Sea . (britannica.com)
  • Colon lies on the eastern shore of Limon Bay at the northern entrance to the Panama canal. (noonsite.com)
  • Colon welcomes you to one of humanity's most extraordinary engineering endeavours, the Panama Canal. (silversea.com)
  • Colon hydrotherapy is an alternative medicine used to relieve problems in the digestive system. (buzzle.com)
  • Upon reaching the left side, the colon again turns sharply toward the inferior direction at the splenic flexure before continuing on as the descending colon. (innerbody.com)
  • A Northampton man going through treatment for colon cancer won a pizza parlor's raffle for a year's worth of free pies and then donated his prize to a food bank. (mcall.com)
  • Q. I was recently diagnosed with colon cancer and will have surgery and then a colostomy. (cancercare.org)
  • Early detection and prompt treatment can significantly improve the life expectancy of a person diagnosed with colon cancer. (buzzle.com)
  • An alternative to colonoscopy uses CT scan images to visualize the colon. (medicinenet.com)
  • As with a conventional colonoscopy, the colon must be emptied as thoroughly as possible prior to the examination. (medicinenet.com)
  • Nielsen said the company is not looking to replace colonoscopy, the current gold standard test for colon cancer. (reuters.com)
  • Colonoscopy - A longer version of the instrument used in sigmoidoscopy is used to see the entire length of the colon. (womenshealthmag.com)
  • Doctors can find colon polyps only by using certain tests or procedures, such as a colonoscopy or imaging study. (nih.gov)
  • The mucosa forms the innermost layer that surrounds the lumen and is in contact with fecal matter stored in the colon. (innerbody.com)
  • Colon ischaemia is the most common ischaemic disorder of the gastrointestinal system, can affect any segment of the colon, and may present with a range of symptoms. (medscape.com)
  • The descending colon is a hollow tube that is part of the gastrointestinal (GI) tract. (innerbody.com)
  • After the water is in the colon, the therapist may massage your abdomen . (webmd.com)
  • Colostomy, which creates an opening through the abdomen where the colon empties into a bag, may be permanent or just used temporarily while the intestines heal. (hopkinsmedicine.org)
  • Colon cleanse is a way of detoxifying the body, especially the digestive system. (buzzle.com)
  • The cancer has reached the outer layers of the colon, but it has not spread beyond the colon. (medicalnewstoday.com)
  • The cancer has grown through the outer layers of the colon, and it has reached one to three lymph nodes. (medicalnewstoday.com)
  • The surgeon will then either reattach the healthy portion of the colon or create a stoma, depending on the extent of the colectomy. (medicalnewstoday.com)
  • Colectomy is a type of colon surgery where the diseased portion of the colon is removed. (hopkinsmedicine.org)
  • Abstract We report a case of survival for nearly 8 years after treatment of unresectable multiple liver metastases from colon cancer, using microwave ablation and the nontoxic antitumor agent, the antineoplastons. (issuu.com)
  • This case report demonstrates the potential effectiveness of the nontoxic antitumor agent, the antineoplastons, for controlling liver metastases from colon cancer. (issuu.com)
  • reported that only a small percentage of patients with synchronous multiple hepatic metastases from colon cancer survive for 2 years.4 We report a patient with colon cancer and synchronous multiple unresectable liver metastases who has survived for nearly 8 years following treatment with microwave ablation and the nontoxic antitumor agent, the antineoplastons. (issuu.com)
  • Our findings may help clarify how to control unresectable metastatic tumors in the liver, originating from colon cancer. (issuu.com)
  • Not a medic, but know that colon metastases to liver and lung are sometimes curable. (cancerresearchuk.org)
  • Since then, the nationally recognized day has grown to be a rallying point for the colon cancer community, when thousands of patients, survivors, caregivers and advocates throughout the country join together to spread colon cancer awareness and raise funds for the cause. (cnbc.com)
  • Colon Cancer Awareness Month is presented by Exact Sciences, with additional support for the effort provided by Boston Scientific Corporation, Dulcolax, and Ferring Pharmaceuticals. (cnbc.com)
  • Colon Cleanse Pro brought to you by the National Diet Team is a natural yet highly effective colon cleanser that can prepare your body for weight loss, detox or weight management. (amazonaws.com)
  • When you first take the Colon Cleanse Pro you may notice your stools become slightly watery and you may empty your bowels more frequently. (amazonaws.com)
  • During the second week of taking the Colon Cleanse Pro you may notice your stools become slightly harder. (amazonaws.com)
  • Colon cleanse is an excellent way to help relieve bloating and constipation and it may also help to improve energy and weight loss. (amazonaws.com)
  • The only side effects that some people may experience when they first start taking Colon Cleanse Pro is minor stomach cramping. (amazonaws.com)
  • If you are looking for a product that may compliment Colon Cleanse Pro please take a look at our Acai Berry Pure and our Thermogenic Max Plus. (amazonaws.com)
  • The National Diet Teams Colon Cleanse Pro compliments all of our weight loss products and we would recommend taking this supplement before starting on any weight loss journey or alongside your chosen weight loss supplement. (amazonaws.com)
  • There are many colon cleanse kits available on the market today. (buzzle.com)
  • Enema, laxatives and herbal teas are some of the ways to cleanse the colon naturally. (buzzle.com)
  • Carrying out a colon cleanse at home is the perfect way to 'service' your body and get it working effectively again. (buzzle.com)
  • Colon cleanse can be done by using high grade sea salt and pure drinking water. (buzzle.com)
  • This modern colon cleanse method also aids in weight loss. (buzzle.com)
  • Colon cleanse pills help clear the bowels of toxin and waste materials. (buzzle.com)
  • There are varieties of natural colon cleanse foods, which help in cleaning the intestines without any side effects. (buzzle.com)
  • The most simple and probably the best way to detoxify the body of children is a natural colon cleanse. (buzzle.com)
  • If you are planning to try the very popular, power colon cleanse, it is extremely crucial to know how it works. (buzzle.com)
  • Maqui colon cleanse is a kind of colon cleaning product that helps to detoxify your body and keep it healthy. (buzzle.com)
  • The following article provides information about this colon cleanse. (buzzle.com)
  • Sometimes, people suffering from constipation, or those who need to cleanse their colon, are asked to undergo enema. (buzzle.com)
  • Most of the black population in Panama is centered in the Province of Colon. (wikipedia.org)
  • Many later settled in the Colon Province. (wikipedia.org)
  • Colón Province is divided into 5 distritos (districts) and subdivided into 40 corregimientos . (wikipedia.org)
  • Your doctor can find colon polyps only by using certain tests or procedures. (nih.gov)
  • They do not cover all of the information that would be in a pathology report that would result from having part of your colon removed (resected) to treat colon cancer. (cancer.org)
  • In this article, we look at how to recognize and treat colon cancer, why it develops, and how to prevent it. (medicalnewstoday.com)
  • Because of side effects of these drugs, taking them every day just to prevent colon cancer is not advised if your cancer risk is only average. (womenshealthmag.com)
  • In many cases, timely screening can prevent colon cancer by finding and removing polyps before they become cancer. (cnbc.com)
  • True, lifestyle can play a role, but you can be at a healthy weight, eat a good diet, exercise regularly, and avoid smoking and alcohol and still develop colon cancer. (aarp.org)
  • There are major risk factors that predispose a person to develop colon cancer. (brighthub.com)
  • Genetic predisposition increases a person's risk to develop colon cancer. (brighthub.com)