They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
The interstitial fluid that is in the LYMPHATIC SYSTEM.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
A system of organs and tissues that process and transport immune cells and LYMPH.
Area of the human body underneath the SHOULDER JOINT, also known as the armpit or underarm.
A layer of the peritoneum which attaches the abdominal viscera to the ABDOMINAL WALL and conveys their blood vessels and nerves.
Infection of the lymph nodes by tuberculosis. Tuberculous infection of the cervical lymph nodes is scrofula.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.
Tumors or cancer of the human BREAST.
Tubular vessels that are involved in the transport of LYMPH and LYMPHOCYTES.
Procedures for collecting, preserving, and transporting of specimens sufficiently stable to provide accurate and precise results suitable for clinical interpretation.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
An encapsulated lymphatic organ through which venous blood filters.
The part of a human or animal body connecting the HEAD to the rest of the body.
Specialized tissues that are components of the lymphatic system. They provide fixed locations within the body where a variety of LYMPHOCYTES can form, mature and multiply. The lymphoid tissues are connected by a network of LYMPHATIC VESSELS.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
Elements of limited time intervals, contributing to particular results or situations.
Ability of neoplasms to infiltrate and actively destroy surrounding tissue.
Tumors or cancer of the STOMACH.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Radiographic study of the lymphatic system following injection of dye or contrast medium.
A malignant epithelial tumor with a glandular organization.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Development of a library collection, including the determination and coordination of selection policy, assessment of needs of users and potential users, collection use studies, collection evaluation, identification of collection needs, selection of materials, planning for resource sharing, collection maintenance and weeding, and budgeting.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Inflammation of the lymph nodes.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm but is often wrongly used as a synonym for "cancer." (From Dorland, 27th ed)
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Dissection in the neck to remove all disease tissues including cervical LYMPH NODES and to leave an adequate margin of normal tissue. This type of surgery is usually used in tumors or cervical metastases in the head and neck. The prototype of neck dissection is the radical neck dissection described by Crile in 1906.
The space or compartment surrounded by the pelvic girdle (bony pelvis). It is subdivided into the greater pelvis and LESSER PELVIS. The pelvic girdle is formed by the PELVIC BONES and SACRUM.
The formation of LYMPHATIC VESSELS.
Tumors or cancer of the SKIN.
Methods or procedures used to obtain samples of URINE.
The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.
Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)
An invasive (infiltrating) CARCINOMA of the mammary ductal system (MAMMARY GLANDS) in the human BREAST.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Newly arising secondary tumors so small they are difficult to detect by physical examination or routine imaging techniques.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Inorganic compounds that contain TECHNETIUM as an integral part of the molecule. Technetium 99m (m=metastable) is an isotope of technetium that has a half-life of about 6 hours. Technetium 99, which has a half-life of 210,000 years, is a decay product of technetium 99m.
A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.
The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
The external junctural region between the lower part of the abdomen and the thigh.
Lymphoid tissue on the mucosa of the small intestine.
Compounds that contain the triphenylmethane aniline structure found in rosaniline. Many of them have a characteristic magenta color and are used as COLORING AGENTS.
A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR D in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.
Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.
Substances that are recognized by the immune system and induce an immune reaction.
Large benign, hyperplastic lymph nodes. The more common hyaline vascular subtype is characterized by small hyaline vascular follicles and interfollicular capillary proliferations. Plasma cells are often present and represent another subtype with the plasma cells containing IgM and IMMUNOGLOBULIN A.
A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in the gastrointestinal system, liver, and spleen.
The tunnel in the lower anterior ABDOMINAL WALL through which the SPERMATIC CORD, in the male; ROUND LIGAMENT, in the female; nerves; and vessels pass. Its internal end is at the deep inguinal ring and its external end is at the superficial inguinal ring.
CCR receptors with specificity for CHEMOKINE CCL19 and CHEMOKINE CCL21. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
An area occupying the most posterior aspect of the ABDOMINAL CAVITY. It is bounded laterally by the borders of the quadratus lumborum muscles and extends from the DIAPHRAGM to the brim of the true PELVIS, where it continues as the pelvic extraperitoneal space.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Tumors or cancer of the ESOPHAGUS.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.
External or interstitial irradiation to treat lymphomas (e.g., Hodgkin's and non-Hodgkin's lymphomas) and lymph node metastases and also some autoimmune diseases, such as rheumatoid arthritis.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Negative test results in subjects who possess the attribute for which the test is conducted. The labeling of diseased persons as healthy when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
Macrophages found in the TISSUES, as opposed to those found in the blood (MONOCYTES) or serous cavities (SEROUS MEMBRANE).
A type of acute or chronic skin reaction in which sensitivity is manifested by reactivity to materials or substances coming in contact with the skin. It may involve allergic or non-allergic mechanisms.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Drug therapy given to augment or stimulate some other form of treatment such as surgery or radiation therapy. Adjuvant chemotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.
Tumors or cancer of the THYROID GLAND.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
Facilities that collect, store, and distribute tissues, e.g., cell lines, microorganisms, blood, sperm, milk, breast tissue, for use by others. Other uses may include transplantation and comparison of diseased tissues in the identification of cancer.
Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.
Recirculating, dendritic, antigen-presenting cells containing characteristic racket-shaped granules (Birbeck granules). They are found principally in the stratum spinosum of the EPIDERMIS and are rich in Class II MAJOR HISTOCOMPATIBILITY COMPLEX molecules. Langerhans cells were the first dendritic cell to be described and have been a model of study for other dendritic cells (DCs), especially other migrating DCs such as dermal DCs and INTERSTITIAL DENDRITIC CELLS.
A malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. (Stedman, 25th ed)
Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Chemicals and substances that impart color including soluble dyes and insoluble pigments. They are used in INKS; PAINTS; and as INDICATORS AND REAGENTS.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651)
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
Immunologic adjuvant and sensitizing agent.
A general term for various neoplastic diseases of the lymphoid tissue.
Cell adhesion molecule and CD antigen that serves as a homing receptor for lymphocytes to lymph node high endothelial venules.
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Surgical procedure to remove one or both breasts.
Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.
Tumors or cancer of the RECTUM.
The relationships of groups of organisms as reflected by their genetic makeup.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
A class of lipoproteins that carry dietary CHOLESTEROL and TRIGLYCERIDES from the SMALL INTESTINE to the tissues. Their density (0.93-1.006 g/ml) is the same as that of VERY-LOW-DENSITY LIPOPROTEINS.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Endoscopic examination, therapy or surgery of the anterior superior mediastinum of the thorax.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.
Ultrasonography of internal organs using an ultrasound transducer sometimes mounted on a fiberoptic endoscope. In endosonography the transducer converts electronic signals into acoustic pulses or continuous waves and acts also as a receiver to detect reflected pulses from within the organ. An audiovisual-electronic interface converts the detected or processed echo signals, which pass through the electronics of the instrument, into a form that the technologist can evaluate. The procedure should not be confused with ENDOSCOPY which employs a special instrument called an endoscope. The "endo-" of endosonography refers to the examination of tissue within hollow organs, with reference to the usual ultrasonography procedure which is performed externally or transcutaneously.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
Tumors or cancer of the UTERINE CERVIX.
Used for excision of the urinary bladder.
A vascular endothelial growth factor that specifically binds to VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2 and VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-3. In addition to being an angiogenic factor it can act on LYMPHATIC VESSELS to stimulate LYMPHANGIOGENESIS. It is similar in structure to VASCULAR ENDOTHELIAL GROWTH FACTOR C in that they both contain N- and C-terminal extensions that were not found in other VEGF family members.
Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells.
Tumors or cancer of the MOUTH.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Excision of part (partial) or all (total) of the esophagus. (Dorland, 28th ed)
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
A cell line derived from cultured tumor cells.
Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.
Cytoplasmic proteins that bind estrogens and migrate to the nucleus where they regulate DNA transcription. Evaluation of the state of estrogen receptors in breast cancer patients has become clinically important.
Forceful administration under the skin of liquid medication, nutrient, or other fluid through a hollow needle piercing the skin.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Death resulting from the presence of a disease in an individual, as shown by a single case report or a limited number of patients. This should be differentiated from DEATH, the physiological cessation of life and from MORTALITY, an epidemiological or statistical concept.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
A round-to-oval mass of lymphoid tissue embedded in the lateral wall of the PHARYNX. There is one on each side of the oropharynx in the fauces between the anterior and posterior pillars of the SOFT PALATE.
A membrane-bound tumor necrosis family member found primarily on LYMPHOCYTES. It can form a heterotrimer (LYMPHOTOXIN ALPHA1, BETA2 HETEROTRIMER) with the soluble ligand LYMPHOTOXIN-ALPHA and anchor it to the cell surface. The membrane-bound complex is specific for the LYMPHOTOXIN BETA receptor.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards T LYMPHOCYTES and B LYMPHOCYTES.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Genotypic differences observed among individuals in a population.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Cells of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B-lymphocytes, can be defined, based on the different classes of immunoglobulins that they synthesize.
Diagnosis of the type and, when feasible, the cause of a pathologic process by means of microscopic study of cells in an exudate or other form of body fluid. (Stedman, 26th ed)
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Tumor-like sterile accumulation of serum in a tissue, organ, or cavity. It results from a tissue insult and is the product of tissue inflammation. It most commonly occurs following MASTECTOMY.
Surgical removal of the thyroid gland. (Dorland, 28th ed)
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Extensive collections, reputedly complete, of facts and data garnered from material of a specialized subject area and made available for analysis and application. The collection can be automated by various contemporary methods for retrieval. The concept should be differentiated from DATABASES, BIBLIOGRAPHIC which is restricted to collections of bibliographic references.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)
Sequential operating programs and data which instruct the functioning of a digital computer.
The preparation of leukocyte concentrates with the return of red cells and leukocyte-poor plasma to the donor.
Cell surface glycoproteins on lymphocytes and other leukocytes that mediate adhesion to specialized blood vessels called high endothelial venules. Several different classes of lymphocyte homing receptors have been identified, and they appear to target different surface molecules (addressins) on high endothelial venules in different tissues. The adhesion plays a crucial role in the trafficking of lymphocytes.
Tumors or cancer of the VULVA.
A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.
The use of combination of imaging techniques or platforms (e.g., MRI SCAN and PET SCAN) encompassing aspects of anatomical, functional, or molecular imaging methods.
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.
An integrin alpha subunit of approximately 150-kDa molecular weight. It is expressed at high levels on monocytes and combines with CD18 ANTIGEN to form the cell surface receptor INTEGRIN ALPHAXBETA2. The subunit contains a conserved I-domain which is characteristic of several of alpha integrins.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
A type I keratin found associated with KERATIN-7 in ductal epithelia and gastrointestinal epithelia.
The passage of viable bacteria from the GASTROINTESTINAL TRACT to extra-intestinal sites, such as the mesenteric lymph node complex, liver, spleen, kidney, and blood. Factors that promote bacterial translocation include overgrowth with gram-negative enteric bacilli, impaired host immune defenses, and injury to the INTESTINAL MUCOSA resulting in increased intestinal permeability. Bacterial translocation from the lung to the circulation is also possible and sometimes accompanies MECHANICAL VENTILATION.
Cell surface glycoproteins that bind to chemokines and thus mediate the migration of pro-inflammatory molecules. The receptors are members of the seven-transmembrane G protein-coupled receptor family. Like the CHEMOKINES themselves, the receptors can be divided into at least three structural branches: CR, CCR, and CXCR, according to variations in a shared cysteine motif.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
Tumors or cancer of the PROSTATE.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Cancers or tumors of the PENIS or of its component tissues.
The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)
An increased reactivity to specific antigens mediated not by antibodies but by cells.
Total mastectomy with axillary node dissection, but with preservation of the pectoral muscles.
The period during a surgical operation.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Experimental transplantation of neoplasms in laboratory animals for research purposes.
Each lymph node is a collection point where APCs can interact with T cells. During the migration, DCs undergo a process of ... they usually migrate to the vast network of lymph vessels and are carried by lymph flow to the draining lymph nodes. ... B cells reside in the lymph node. Once their B cell receptor binds to an antigen, they can interact with activated helper T ... It moves from the tissue to lymph nodes, where it encounters and activates T cells. Macrophages can be stimulated by T cell ...
Other fluid collections to be considered in the differential diagnosis are urinoma, seroma, hematoma, as well as collections of ... If the injury is minor, collateral channels will transport lymph fluid, but with extensive damage, fluid may accumulate in an ... A lymphocele is a collection of lymphatic fluid within the body not bordered by epithelial lining. It is usually a surgical ... Typical operations leading to lymphocysts are renal transplantation and radical pelvic surgery with lymph node removal because ...
There may also be intra-oral halitosis, cervical lymphadenitis (swollen lymph nodes in the neck) and malaise. Predisposing ... An abscess is a localized collection of pus which forms during an acute infection. The important difference between a ...
... and endoscopic ultrasound with fine-needle aspiration of mediastinal lymph nodes (EBUS FNA). Tissue from biopsy of lymph nodes ... As the granulomas are caused by collections of immune system cells, particularly T cells, there has been some success using ... Findings that make it likely include large lymph nodes at the root of the lung on both sides, high blood calcium with a normal ... Sarcoidosis in a lymph node Asteroid body in sarcoidosis Micrograph showing pulmonary sarcoidosis with granulomas with asteroid ...
According to the diagnostic criteria, at least one impaired lymph node ≥ 15 mm in diameter should be involved. Affected lymph ... Bailie NM, Hensey OJ, Ryan S, Allcut D, King MD (2001). "Bilateral subdural collections--an unusual feature of possible ... Other common symptoms include large lymph nodes in the neck, a rash in the genital area, lips, palms, or soles of the feet, and ... Kawasaki T, Kosaki F, Okawa S, Shigematsu I, Yanagawa H (September 1974). "A new infantile acute febrile mucocutaneous lymph ...
These lymph vessels can become blocked due to the collection of lymph which forms a cyst as a mass, and are known as ... Low-flow malformations involve a single type of blood or lymph vessel, and are known as simple vascular malformations; high- ... A vascular malformation, is a blood vessel or lymph vessel abnormality. Vascular malformations are one of the classifications ... Abnormal development of the lymph vessels results in their failure to connect and drain into the venous system. ...
In dogs it affects the gastrointestinal system and lymph nodes, and rarely the skin. Mucormycosis is a collection of fungal and ... Polyneuropathy is a collection of peripheral nerve disorders that often are breed-related in dogs. Polyneuropathy indicates ... Pericardial effusion* is a collection of fluid in the pericardium. It is usually serosanguinous (bloody fluid). Serosanguinous ... Congenital vertebral anomalies, including butterfly, block, and transitional vertebrae, and hemivertebrae, are a collection of ...
A lymph node is an organized collection of lymphoid tissue, through which the lymph passes on its way back to the blood. Lymph ... Lymph then passes into much larger lymph vessels known as lymph ducts. The right lymphatic duct drains the right side of the ... Lymph is moved through the system by muscle contractions. In some vertebrates, a lymph heart is present that pumps the lymph to ... The efferent lymph vessel directly emerges from the lymph node at the hilum. The arteries and veins supplying the lymph node ...
Part of the renal cortex, a medullary ray is a collection of renal tubules that drain into a single collecting duct. ... Hilar fat and lymphatic tissue with lymph nodes surrounds these structures. The hilar fat is contiguous with a fat-filled ...
Lymphatic malformation is more commonly used now because it is a sponge-like collection of abnormal growth that contains clear ... Microscopically, cystic hygroma consists of multiple locules filled with lymph. In the depth, the locules are quite big but ... It contains large cyst-like cavities containing lymph, a watery fluid that circulates throughout the lymphatic system. ...
A lymph node is an organized collection of lymphoid tissue, through which the lymph passes on its way back to the blood. Lymph ... Several afferent lymph vessels bring in lymph, which percolates through the substance of the lymph node, and is then drained ... The efferent lymph vessel directly emerges from the lymph node at the hilum. The arteries and veins supplying the lymph node ... The last of the lymph sacs, the paired posterior lymph sacs, develop from the iliac veins. The posterior lymph sacs produce ...
Additionally, peripheral lymph nodes will swell, and internal organs such as the kidney and lungs may become distended. Head, ... neck, feet, general body, mouth and tongue Kidneys and ureters may become distended with mucous and debris collection; ...
These are separated from the fundamental network of lymph vessels. Communication between the superficial lymph vessels is ... The pathologic process involves the collection of lymphatic cisterns within the deep subcutaneous layer of the skin. ... a mass of abnormal swollen veins and lymph nodes, or a tumorous growth of lymph and blood vessels. Oftentimes, it is described ... The malformation arises from when the primitive lymph sac is unable to connect with the rest of the lymphatic system during ...
The collection of this fluid is carried out by the initial lymph collectors that are blind-ended epithelial-lined vessels with ... Once the lymph enters the fully valved lymphatic vessels, it is pumped by a rhythmic peristaltic-like action by smooth muscle ... The lymph ends its journey in the thoracic duct or right lymphatic duct, which drain into the blood circulation.[citation ... Lymph is formed from the fluid that filters out of the blood circulation and contains proteins, cellular debris, bacteria, etc ...
Lymph node aspirate and chylous fluid may also yield microfilariae. Medical imaging, such as CT or MRI, may reveal "filarial ... Examples are W. bancrofti, whose vector is a mosquito; night is the preferred time for blood collection. Loa loa's vector is ... These worms occupy the lymphatic system, including the lymph nodes; in chronic cases, these worms lead to the syndrome of ... the deer fly; daytime collection is preferred. This method of diagnosis is only relevant to microfilariae that use the blood as ...
A week later the phone rang and I was told that I had a cancer of the testicles that had spread to a lymph node and to one lung ... He has also written a collection of essays, Love in a Dark Time: Gay Lives from Wilde to Almodóvar (2002), and a study on Lady ... In his 2012 essay collection New Ways to Kill Your Mother: Writers and Their Families he studies the biographies of James ... liver and lymph node. Tóibín's 1990 novel The South was followed by The Heather Blazing (1992), The Story of the Night (1996) ...
... the prelymphatics or lymph capillaries that specialize in collection of the lymph from the ISF, and the larger lymph vessels ... Lymph vessels that carry lymph to a lymph node are called afferent lymph vessels, and those that carry it from a lymph node are ... lymph ducts, or may empty into another lymph node as its afferent lymph vessel. Both the lymph ducts return the lymph to the ... The lymph percolates through the lymph node tissue and exits via an efferent lymph vessel. An efferent lymph vessel may ...
2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome ... identifies breast cancer micrometastases in sentinel lymph nodes". Am. J. Clin. Pathol. 121 (5): 637-43. doi:10.1309/MMAC-TXT5- ...
2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome ... 2005). "Amplification of Cyclin L1 is associated with lymph node metastases in head and neck squamous cell carcinoma (HNSCC)". ...
Lymphedema: this is when swelling occurs around the scrotum area due to collection of lymph fluid, which may cause the penis to ... In relation to lymphedema - When the lymph system operates normally, the lymph circulates through a series of vessels and ducts ... It then returns to the bloodstream with lymph. A blocking or failure in the genital area of this system may lead to a lymphatic ...
The rare collection is held at the National Library of Scotland (NLS) in Edinburgh, Scotland. Only one other collection of ... They reveal the shift from variolation, improved vaccination techniques, and the logistics of lymph supply, as well information ... "India Papers Collection - Official Publications Collections - National Library of Scotland - National Library of Scotland". www ... The Drugs collection is made up of nine volumes, dating from 1867 to 1903. It contains reports detailing research on hemp and ...
... these earlier collections were dispersed during the French Revolution. The cabinet's anatomical collection was reorganized and ... lymph systems (Marie Philibert Constant Sappey), kidney structure (Augier), trachea (Eralp), esophagus (Sussini), and liver. It ... In 2011 the collections were donated to the University of Montpellier and are on display in the Medical School. The museum ... Although the city had contained earlier, amateur collections, including a set of more than 1000 wax anatomical models ...
In the case of cancer, invasion into the thoracic duct or collateral lymph channels can obstruct lymph. In the case of ... In people on a normal diet, this fluid collection can sometimes be identified by its turbid, milky white appearance, since ... A chylothorax is an abnormal accumulation of chyle, a type of lipid-rich lymph, in the space surrounding the lung. The ... This impedes the centripetal drainage of the flow of lymph from the edges of the lung parenchyma and pleural surfaces. This ...
A therapeutic approach targeting towards the reduction of such tumor collections could be induced by ganitumab. Ganitumab is a ... and secondary lymph nodes (Kaposi sarcoma). IGF-1R allows the activation of these signaling pathways and subsequently regulates ... A therapeutic approach targeting towards the reduction of such tumor collections could be induced by ganitumab. Ganitumab is a ... and secondary lymph nodes (Kaposi sarcoma). IGF-1R allows the activation of these signaling pathways and subsequently regulates ...
... the prelymphatics or lymph capillaries that specialize in collection of the lymph from the ISF, and the larger lymph vessels ... Lymph vessels that carry lymph to a lymph node are called afferent lymph vessels, and those that carry it from a lymph node are ... lymph ducts, or may empty into another lymph node as its afferent lymph vessel.[4] Both the lymph ducts return the lymph to the ... Here the lymph percolates through the lymph node tissue and is removed by the efferent lymph vessel. An efferent lymph vessel ...
Rare manifestations include lymph node disease resembling tuberculosis, mediastinal masses, collection of fluid in the heart ... About 1 to 5% of those infected develop inflammation of the brain and brain covering or collection of pus in the brain; 14 to ... Tuberculosis should be considered if lymph nodes are enlarged at the root of the lung. Pneumonia caused by melioidosis rarely ...
"The Gordon Museum collection Artefacts". Gordon Museum of Pathology. Retrieved 22 October 2015. "The Gordon Museum collection ... adrenal glands and lymph nodes which led Thomas Hodgkin, Thomas Addison and Richard Bright to describe the medical conditions ... The Museum also houses a number of historic collections and artefacts, for example Joseph Lister's antiseptic spray, and Thomas ... "The Gordon Museum collection". Gordon Museum of Pathology. Retrieved 22 October 2015. " ...
... a software development methodology in which the system is modeled as a collection of objects that collaborate to fulfill the ... responsibilities Rosai-Dorfman disease, a disorder characterized by abundant histiocytes in lymph nodes and elsewhere in the ...
... concerning the thyroid gland Lymph node cytology - concerning lymph nodes Respiratory cytology - concerning the lungs and ... In intervention cytology the pathologist intervenes into the body for sample collection. Fine-needle aspiration, or fine-needle ... ISBN 0-304-31806-X. "Cytology". Collection development manual of the National Library of Medicine (4th ed.). Bethesda, MD: ... Cytotechnologists and cytopathologists can assist clinicians by assisting with sample collection. A "quick read" is a peek ...
... that later was added to the collection of Elizabeth Philpot and today is registered in the Lyme Regis Museum as specimen LYMPH ... Several specimens remain undescribed because they are in private collections. These include a 3.1 metres (ten feet) long ... Specimen CAMSMX.39256 is part of the collection of the Sedgwick Museum at Cambridge. ... that had been acquired by the BMNH from the Norris collection. Owen in 1861 described a second, partial, skeleton of a juvenile ...
Tissue Collection for Studies of Lymph Cancer. This study is currently recruiting participants. See Contacts and Locations ... To develop these studies, researchers want to collect samples from people with cancer or precancer conditions of the lymph ...
Raymond U. Osarogiagbon, MBBS, on NSCLC: A Lymph Node Collection Kit 2018 ASCO Annual Meeting. Advertisement ...
Innsamling og behandling av Lymph noder fra store dyr for RNA analyse: forbereder lymfeknute Transcriptomic studier av store ... JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Biopharma Archive *ISSN 1940-087X ... Innsamling og behandling av Lymph noder fra store dyr for RNA analyse ... inkludert trinnene i identifikasjon og excision av lymph noder fra husdyr og dyreliv, prøvetaking metoder å gi konsistens på ...
JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Biopharma Archive *ISSN 1940-087X ...
lymph nodes Dr. Axe on Facebook 17065 Dr. Axe on Twitter 101 Dr. Axe on Instagram Dr. Axe on Google Plus Dr. Axe on Youtube Dr ...
... in determining lymph node involvement. Although magnetic resonance imaging and computed tomography are commonly used for lymph ... Imaging of lymph node metastases in cervical cancer. Marcus Q. Bernardini and Allan Covens ... Given that most studies of early cervical cancer reported a less than 10% incidence of lymph node metastases,7 the post-test ... Examples comparing the detection of positive lymph nodes using the three imaging methods are shown in Figure 1, Figure 2, ...
In this study, the local recruitment and activation of immune cells in draining lymph nodes (LNs) was studied in calves in an ... Moreover, monocytes from the draining lymph node showed a high expression of genes coding for pro-inflammatory cytokines, ... Moreover, monocytes from the draining lymph node showed a high expression of genes coding for pro-inflammatory cytokines, ... In this study, the local recruitment and activation of immune cells in draining lymph nodes (LNs) was studied in calves in an ...
Donors and sample collection.. PB was collected before transplantation from patients with type 1 diabetes undergoing pancreas ... Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature 2005;435:224-228 ... Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients ... Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients ...
CD169 mediates the capture of exosomes in spleen and lymph node. Sarah C. Saunderson, Amy C. Dunn, Paul R. Crocker, Alexander D ... CD169 mediates the capture of exosomes in spleen and lymph node. Sarah C. Saunderson, Amy C. Dunn, Paul R. Crocker, Alexander D ... CD169 mediates the capture of exosomes in spleen and lymph node. Sarah C. Saunderson, Amy C. Dunn, Paul R. Crocker and ... Exosomes are bound by CD169+ macrophages in the spleen and LN in the absence of blood or lymph flow. Exo-bio was applied to ...
Fibronectin fibers are highly tensed in healthy organs in contrast to tumors and virus-infected lymph nodes. * Mendeley ... In contrast, tumor tissues and virus-infected lymph nodes exhibited a significantly higher content of relaxed or ...
1) Lymphatic cannulation and lymph collection will allow the qualitative and quantitative phenotypical analysis of lymph- ... As such, lymph collection from the vessel draining the site of injection into the regional node can prove very useful for ... 6). Thus, lymph collection will prove very useful for the phenotypic and functional analysis of patrolling immune cells and ... 3G, 3H). Lymphatic harvesting, cannulation, and lymph collection from the skin are identical to what is reported in Fig. 1. ...
... a comprehensive collection of slide seminars including histopathology slides of rare and educational pathological cases ... Rosai-Dorfman disease in lymph node and salivary gland (Lymph node (parotid region)) [1140/6] ... Seminar 1140: Pathology of lymph nodes and spleen, November, 1999. California Tumor Registry Monthly Sets (CTRMS). Seminar ... Monocytoid B cell lymphoma wih transformation into diffuse large B cell lymphoma (Lymph node) [1140/10] ...
... sentinel lymph node biopsy (SLNB) recommendations in guidelines for cutaneous melanoma have changed considerably. We aimed to ... Collection of Data. Data for this retrospective nationwide study were derived from PALGA, the Dutch nationwide network and ... To prevent confounding by indication, patients with other lymph node-related procedures, such as complete lymph node dissection ... procedure to identify the exact location of the first draining lymph node,3 it became possible to both perform a targeted lymph ...
HOME » Anatomia Collection » Vasorum lymphaticorum corporis humani historia et ichnographia. » Inguinal lymph nodes and ... Inguinal lymph nodes and lymphatic venules of the legs. Return to Book View. ... Inguinal lymph nodes and lymphatic ducts of the legs, shown in situ, in 2 numbered illustrations. Lateral and medial views. ...
Collection of airway, lung lymph node, and spleen cells. Airway cells were obtained by bronchoalveolar lavage (BAL) as ... The draining lymph nodes (mediastinal lymph node (MLN)) from the lungs were aseptically removed, passed through a 70-μm cell ... Schu4 replicates in the airways and draining lymph node of the lungs. Mice were infected with a low-dose aerosol of Schu4 (50 ... The primary function of DC is to carry Ag to the draining lymph node for presentation to effector T cells. During this ...
Specimen Collection and Transport Guidelines for Suspect Smallpox Cases ... Specimen Collection and Transport Guidelines for Suspect Smallpox Cases. *Specimen Collection and Transport Guidelines for ... Preparation for Specimen Collection. Collection of specimens can begin after appropriate consultations have been made. ... Specimen collection procedures: *Minimize the number and extent of procedures, both to decrease opportunities for worker risk ...
View Stock Photo of Normal Human Lymph Node Showing The Margin Of A Follicle With Small Lymphocytes On The Left And The ... Collection:Visuals Unlimited. Max file size:4817 x 3400 px (16.06 x 11.33 in) - 300 dpi - 5.48 MB ... Normal human lymph node showing the margin of a follicle with small lymphocytes on the left and the germinal center on the ...
View Stock Photo of Histoplasma Capsulatum Fungus Fills The Cytoplasm Of Many Cells In The Lymph Node Of An Elderly Man On ... Collection:Visuals Unlimited. Max file size:5100 x 3400 px (17.00 x 11.33 in) - 300 dpi - 7.76 MB ... Histoplasma capsulatum Fungus fills the cytoplasm of many cells in the lymph node of an elderly man on long-term steroid use, ...
Lymph Nodes. Part of Book Traité complet de lanatomie de lhomme comprenant la medecine operatoire, par le docteur Bourgery. ... Lymphatic vessels and lymph nodes of the thorax, abdomen and pelvis. Return to Book View. ... Lymphatic vessels and lymph nodes of the thorax, abdomen and pelvis, shown in situ. Anterior thoracic and abdominal wall ... HOME » Anatomia Collection » Traité complet de lanatomie de lhomme comprenant la medecine operatoire, par le docteur Bourgery ...
Tissue collection and processing. Oral mucosal and LN biopsy specimens, as well as peripheral blood, were obtained from ... Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1. Blood 109:4272-4279. [PubMed ... Expression of IFN-gamma induced CXCR3 agonist chemokines and compartmentalization of CXCR3+ cells in the periphery and lymph ... Elevated Levels of Innate Immune Modulators in Lymph Nodes and Blood Are Associated with More-Rapid Disease Progression in ...
This publication presents data from over four years of sentinel lymph node biopsy (SLNB) collection. The histological ... Wagner JD, Davidson D, Coleman JJ, et al. Lymph node tumour volumes in patients undergoing sentinel lymph node biopsy for ... Jansen L, Nieweg OE, Peterse JL, et al. Reliability of sentinel lymph node biopsy for staging melanoma. Br J Surg 2000;87:484-9 ... SLNB is very accurate in predicting the status of the remaining regional lymph nodes,7,12-14 and is currently the most ...
Mapping mononuclear phagocytes in blood, lungs, and lymph nodes of sarcoidosis patients. ... Mapping[Title] AND mononuclear[Title] AND phagocytes[Title] AND blood[Title] AND lungs[Title] AND lymph[Title] AND nodes[Title ... Search: Mapping[Title] AND mononuclear[Title] AND phagocytes[Title] AND blood[Title] AND lungs[Title] AND lymph[Title] AND ... Search: Mapping mononuclear phagocytes in blood lungs and lymph node.... *. Number of items displayed:. 5. 10. 15. 20. 50. 100 ...
Lymph node collection kit improves outcomes of lung cancer resection. August 15, 2018. CHICAGO - The use of a lymph node ... specimen collection kit during non-small cell lung cancer resection significantly improved staging quality… ...
By contrast, mesenteric lymph drainage increased the 2,3-DPG level in the renal tissue. These findings indicated that ... Mesenteric lymph drainage lessened the following: renal tissue damage; urea and trypsin concentrations in the plasma; ICAM-1, ... The hemorrhagic shock model (40 mmHg, 3 h) was established in shock and drainage groups; mesenteric lymph drainage was ... mesenteric lymph drainage could relieve kidney injury caused by sustained hypotension, and its mechanisms involve the decrease ...
... lymph node status; oestrogen receptor status; progesterone receptor status; human epidermal growth factor receptor 2 status; ... 6 Recommendations for further data collection. 6 Recommendations for further data collection. 6.1 Clinicians should enter ...
Tracheal venous blood and lymph collection : A model to study airway injury in sheep. / Barrow, R. E.; Morris, S. E.; Linares, ... Barrow RE, Morris SE, Linares HA, Herndon D. Tracheal venous blood and lymph collection: A model to study airway injury in ... Tracheal venous blood and lymph collection : A model to study airway injury in sheep. In: Journal of Applied Physiology. 1991 ... Barrow, R. E., Morris, S. E., Linares, H. A., & Herndon, D. (1991). Tracheal venous blood and lymph collection: A model to ...
This item appears in the following Collection(s). * HMS Scholarly Articles [21285]. ... Direct in vivo imaging of lymph flow is key to understanding lymphatic system function in normal and disease states. Optical ... In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography. ... In vivo label-free measurement of lymph flow velocity and volumetric flow rates using Doppler optical coherence tomography. ...
Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response The bee venom melittin has ... which correlates with metronidazole resistance status in a large international collection of CD isolates, and demonstrate that ...
Lymph node metastasis (p , 0.001) and molecular subtyping (p = 0.002) were independent factors associated with SPA17 expression ... Clinical Specimens and Collection of Clinicopathological Parameters as Well as Follow-Up Information. The 100 samples of ... B) SPA17 protein expression in lymph node negative and lymph node positive breast cancer patients. (C) SPA17 positive ... Lymph node metastasis (p , 0.001) and molecular subtyping (p = 0.002) were independent factors associated with SPA17 expression ...
  • In this issue of CMAJ , Selman and colleagues 5 have performed a systematic review and meta-analysis of the literature on the diagnostic accuracy of magnetic resonance imaging, computed tomography, positron emission tomography and sentinel node biopsy in determining lymph node status in patients with cervical cancer. (
  • They concluded that sentinel node biopsy was the most accurate (positive likelihood ratio 40.8) and positron emission tomography the next most accuracte (positive likelihood ratio of 15.3) in determining lymph node involvement. (
  • The bulk of the literature on sentinel node biopsy focuses on the early stages of disease and exploring the use of sentinel lymph node identification as part of the extirpative surgical procedure, with the goal of minimizing operative and postoperative morbidity from the lymphadenectomy. (
  • Over recent years, sentinel lymph node biopsy (SLNB) recommendations in guidelines for cutaneous melanoma have changed considerably. (
  • With the introduction of the sentinel lymph node biopsy (SNLB) procedure to identify the exact location of the first draining lymph node, 3 it became possible to both perform a targeted lymph node dissection aiming to improve the prognosis of SLNB-positive patients, and deny SLNB-negative patients a superfluous surgical procedure. (
  • Sentinel lymph node biopsy (SLNB) is an important component in the staging and treatment of cutaneous melanoma (CM). The medical literature provides only limited information regarding melanoma sentinel lymph node (SLN) histology. (
  • Sentinel lymph node biopsy is unsuitable for routine practice in younger female patients with unilateral low-risk papillary thyroid carcinoma. (
  • BACKGROUND: Sentinel lymph node (SLN) biopsy has been used to assess patients with papillary thyroid carcinoma (PTC). (
  • Thus, a combined SLN biopsy technique seems to more accurately stage lymph nodes, with better identification of SLN located out of the central compartment. (
  • To evaluate the magnitude of M. tuberculosis from lymph node biopsy paraffin-embedded sections among suspected patients visiting the Jimma University Specialized Hospital. (
  • A cross-sectional study design of histological examination among lymph node biopsy paraffin-embedded sections by Ziehl-Neelsen and hematoxylin/eosin staining technique was conducted from December, 2009, to October, 2010, at the Department of Medical Laboratory Science and Pathology. (
  • We report microbiologic analysis of 786 lymph node biopsy specimens from patients with suspected cat-scratch disease (CSD). (
  • Histologic analysis of lymph node biopsy specimens should be routinely performed because some patients might have a concurrent malignant disease or mycobacteriosis. (
  • As a national reference center for rickettsioses and bartonelloses, we routinely receive lymph node biopsy specimens from patients with suspected CSD. (
  • In this study, we analyzed a large collection of lymph node biopsy samples obtained from January 2001 through August 2005 using microbial cultures (blood agar culture and cell culture) and 16S rDNA- and Bartonella -specific PCR. (
  • We studied lymph node biopsy specimens from patients with suspected CSD that were collected from January 2001 through August 2005. (
  • Seven trials including 9426 patients compared ALND with sentinel lymph node biopsy (SLNB). (
  • The present study aimed to identify and preserve the stained non‑SLNs and evaluate the safety during sentinel lymph node biopsy (SLNB) in breast cancer. (
  • Sentinel lymph node biopsy (SLNB) was introduced in the 1990s ( 1 ). (
  • Sentinel lymph node (SLN) identification and biopsy has become clinical practise in other areas including breast, skin, and gastric cancer. (
  • A prospective clinical trial using a commercially available NIR system and ICG injection around the tumour site will evaluate the ability to detect and biopsy sentinel lymph nodes in head and neck cancer patients. (
  • This is most often done using a sentinel lymph node biopsy (SLNB) . (
  • What is a Sentinel Lymph Node Breast Biopsy? (
  • A sentinel lymph node biopsy can be done at the same time as a lumpectomy or a mastectomy when there's no sign that cancer has spread to the lymph nodes. (
  • During the biopsy, 1 or more lymph nodes are removed. (
  • These factors include large tumour size (≥ 4 cm), deep stromal invasion (outer third of cervical stroma), vascular space involvement, parametrial tissue invasion, positive surgical margins and lymph node metastasis. (
  • Nascimbeni R, Burgart LJ, Nivatvongs S, Larson DR. Risk of lymph node metastasis in T1 carcinoma of the colon and rectum. (
  • Background: Preoperative risk stratification is essential in tailoring endometrial cancer treatment, and biomarkers predicting lymph node metastasis and aggressive disease are aspired in clinical practice. (
  • DNA ploidy assessment in preoperative curettage specimens is less studied, and in particular in relation to the occurrence of lymph node metastasis. (
  • Non-diploid status significantly correlated with traditional aggressive postoperative clinicopathological features, and was an independent predictor of lymph node metastasis among FIGO stage I-III patients in multivariate analysis (OR 1.94, P=0.033). (
  • Conclusions: Non-diploid curettage is significantly associated with aggressive clinicopathological phenotype, lymph node metastasis, and poor survival in endometrial cancer. (
  • In this article, we report the presence of a true intrathyroid lymph node and describe the first reported case of intrathyroid lymph node metastasis of papillary thyroid cancer. (
  • 3.4.3 Significance of Mediastinal Lymph Node Metastasis in Carcinoma of the Lung. (
  • In this study, the local recruitment and activation of immune cells in draining lymph nodes (LNs) was studied in calves in an adjuvant-induced inflammation. (
  • RESEARCH DESIGN AND METHODS We phenotypically and functionally characterized Th17 cells and Tregs residing in the pancreatic-draining lymph nodes (PLNs) of 19 patients with type 1 diabetes and 63 nondiabetic donors and those circulating in the peripheral blood of 14 type 1 diabetic patients and 11 healthy subjects. (
  • However, the low incidence of lymph node metastases in these patients will make it difficult for any imaging method to be useful in the clinical setting. (
  • Reasoning from the concept of a stepwise spread of metastases through locoregional lymph nodes before going into the bloodstream to distant sites, locoregional lymph node dissection was introduced as a therapeutic procedure. (
  • Furthermore, the MSLT-II trial showed that additional complete lymph node dissection does not increase melanoma-specific survival among patients with sentinel node metastases. (
  • This report details the specific histological patterns of melanoma metastases in sentinel lymph nodes (SLNs) and highlights some key factors in evaluating SLNs for melanoma. (
  • Detection of lymph node metastases in colorectal carcinoma before and after fat clearance. (
  • Stage for stage, women with para-aortic lymph node metastases at presentation have a lower survival than those who do not have para-aortic metastases at presentation. (
  • Sugie et al ( 11 ) and Inoue et al ( 12 ) have published data on the removal of enlarged lymph nodes that are hard, palpable and suspicious for metastases, and can therefore be considered SLNs. (
  • Since MMP-9 shows very strong correlation with CK19 mRNA in breast carcinoma of no special type metastases, expression of MMP-9 in sentinel lymph nodes should be considered as useful method whenever OSNA analysis is not available. (
  • 3.4.4 Radiologic Assessment of Metastases to Mediastinal Lymph Nodes. (
  • However, for many sites of the body (apart from the extremities), the nearest lymph node basin is not obvious, making it often difficult to decide where to perform lymph node dissection and failing to improve prognosis. (
  • The review identified 26 randomised controlled trials that compared axillary lymph node dissection (ALND) with alternative approaches involving less axillary surgery. (
  • An inguinal lymph node dissection is surgery to remove the lymph nodes from the groin. (
  • An inguinal lymph node dissection is done under general anesthetic in a hospital operating room. (
  • Depending on how many lymph nodes are affected, the surgeon may remove only the superficial inguinal lymph nodes or both the superficial and deep inguinal lymph nodes (a complete inguinal lymph node dissection). (
  • People who have an inguinal lymph node dissection are usually sent home a few hours to a few days after surgery. (
  • Side effects can happen any time during, immediately after or a few days or weeks after an inguinal lymph node dissection. (
  • Sometimes late side effects develop months or years after an inguinal lymph node dissection. (
  • A lymphadenectomy, also called lymph node dissection, may be done to examine the pelvic and para-aortic lymph nodes for endometrial cancer cells. (
  • This is called a full axillary lymph node dissection. (
  • Sentinel lymph nodes (SLNs) are the first lymph nodes that receive lymphatic drainage from the breast. (
  • The aim of this proposal is to evaluate the potential application of Indocyanine Green (ICG) in the mapping and detection of sentinel lymph nodes (SLN) in cancers of the head and neck. (
  • The gold standard for detecting metastatic lymph nodes is pathological analysis, but the lack of an accurate or clinically accepted way to identify sentinel lymph nodes in the cervical region has motivated the usage of indocyanine green (ICG) and near-infrared fluorescence (NIR) imaging (Pinpoint, Novadaq, Waterloo). (
  • One-step nucleic acid amplification (OSNA) detects and quantifies, with the use of a polymerase chain reaction, the presence of cytokeratin 19 mRNA in sentinel lymph nodes. (
  • The objective of this study was to evaluate the significance of matrix metalloproteinase 9 expression by immunohistochemistry as supporting marker to cytokeratin 19 mRNA in sentinel lymph nodes in breast cancer patients and to relate this expression with clinicopathological data. (
  • This study was conducted on fresh sentinel lymph nodes obtained from 40 patients with tumors classified as carcinoma of no special type. (
  • The lymphatic system helps fight infections and is made up of lymph vessels, lymph fluid, lymph nodes, bone marrow and the lymphatic organs (thymus, adenoid, tonsil and spleen). (
  • The major organs of the immune system include the spleen, thymus,lymph nodes and bone marrow. (
  • of immature lymphoid cells in the bone marrow and lymph nodes. (
  • We show that this technique can measure lymph velocity at sufficiently high temporal resolution to resolve the dynamic pulsatile flow in collecting lymphatic vessels. (
  • Cervical cancer spreads to the lymph nodes in the pelvis and around the aorta (one of the major blood vessels in the abdomen). (
  • The lymphatic vessels entering the lymph nodes are called afferent lymphatic vessels and those exiting are called efferent lymphatic vessels. (
  • Drainage of fluid from blood stream into the tissues - The circulating blood through narrow vessels leads to leakage of fluid or plasma into the tissues carrying oxygen and nutrients to the tissues and carrying waste materials from the tissues into the lymph channels. (
  • The leaked fluid drains into the lymph vessels. (
  • The first lymph node, which was connected with lymphatic vessels from the breast, was designated as the true SLN. (
  • As the ICG fluorescence technique can identify the basin that includes not only SLNs but also para-SLNs where the lymphatic vessels drain, the average number of lymph nodes removed also tends to increase. (
  • Lymph vessels are very thin tubes similar to blood vessels. (
  • This category is for questions about the various vessels by which lymph, a watery fluid of leukocytes, circulates through the body, providing transportation for some materials and removing particulate from tissues. (
  • It's made up of lymph nodes and vessels that carry lymph fluid throughout the body. (
  • Obesity affects the skin barrier function, workings of the sebaceous glands and sebum production that keeps the skin moisturized and supple, sweat glands, small lymph channels under the skin, collagen structure and function, wound healing, small blood vessels under the skin, and subcutaneous fat. (
  • This study has identified a novel capture mechanism for host-derived vesicles within the spleen and lymph node. (
  • Exosome-capturing macrophages were present in the marginal zone of the spleen and in the subcapsular sinus of the lymph node. (
  • In vitro assays performed on spleen and lymph node sections confirmed that exosome binding to CD169 was not solely due to preferential fluid flow to these areas. (
  • The lymphatic system includes your spleen, thymus, lymph nodes and lymph channels, as well as your tonsils and adenoids. (
  • Kim et al ( 6 ) reported that the removal of at least two lymph nodes during SLNB may be acceptable. (
  • In the present study, SLNB was performed with methylene blue (MB) and the indocyanine green (ICG) double-tracer technique, and all the stained lymph nodes were observed carefully. (
  • In contrast, tumor tissues and virus-infected lymph nodes exhibited a significantly higher content of relaxed or proteolytically cleaved fibronectin fibers. (
  • Multivariate analysis showed that age, tumor size, specimen length, use of a pathology template, and academic status of the hospital were significant predictors of the number of lymph nodes assessed. (
  • SLNs are theoretically the first lymph nodes reached by metastatic cancer cells that migrate from a primary tumor to the breast ( 13 ). (
  • Tumor tissue and regional lymph node samples are collected during surgery for analysis of micrometastases and molecular markers by immunohistochemistry, qRT-PCR, MM qRT-PCR, qRDNA-PCR, and microarray profiling. (
  • The sentinel node is the first lymph node that a tumor drains into. (
  • When cancer cells break away from the initial tumor, they can travel through the blood or the lymph system to other parts of the body and form new tumors. (
  • The information contained on this webpage regarding collection of specimens for variola virus (smallpox) diagnostic testing and their transportation replaces the previous document known as "Guide D - Specimen Collection and Transport Guidelines. (
  • Collection of specimens can begin after appropriate consultations have been made. (
  • Lymph node recovery from colorectal resection specimens removed for adenocarcinoma. (
  • SLNs are detected by injecting a dye into the breast and detecting the first draining lymph node(s), which is/are subsequently sampled as pathological specimens. (
  • We designed it to improve the intraoperative retrieval of lymph nodes compatible with evidence-based guidelines, the secure transfer of lymph node specimens between surgery and pathology teams, and the accurate identification of the anatomic provenance of lymph node specimens to encourage thorough and accurate pathologic evaluation,' he said. (
  • Lymph fluid from these lymph nodes drains into another group of lymph nodes inside the abdomen called the pelvic lymph nodes. (
  • This means that cancer from the inguinal lymph nodes can spread to the pelvic lymph nodes. (
  • Indeed, every pelvic collection (blood or lymph) tends to recur. (
  • Your pelvic lymph nodes are enlarged. (
  • To collect tissue samples to study different types of lymph cancer. (
  • A protective immune response to infection or vaccination is dependent on the recruitment of immune cells to the inflamed tissue, followed by their activation and the subsequent movement of cells and antigens to the draining lymph node (LN). In this respect, the migration of antigen-loaded dendritic cells (DCs) and recirculating lymphocytes has been extensively studied [reviewed by Girard et al. (
  • The propensity of HIV to utilize mucosal transmission to spread to new hosts suggests that developing an effective HIV vaccine will likely require an in-depth understanding of these earliest events at the mucosal sites, as well as the subsequent events that follow at other tissue sites such as lymph nodes (LN) and blood. (
  • By contrast, mesenteric lymph drainage increased the 2,3-DPG level in the renal tissue. (
  • The objective of this study was to use NGS 16S amplicon analysis to identify bacteria in post-mortem lung and lymph node tissue samples harvested from fatal BRD cases and clinically healthy animals. (
  • Cranial lobe and corresponding mediastinal lymph node post-mortem tissue samples were collected from calves diagnosed as BRD cases by veterinary laboratory pathologists and from clinically healthy calves. (
  • Lymph nodes are small bean-shaped organs of lymphatic tissue. (
  • The lymph nodes and any other tissue removed during surgery are sent to a lab to be examined by a doctor who specializes in the causes and nature of disease (a pathologist). (
  • This leads to collection of protein-rich lymphatic fluid in the subcutaneous tissue. (
  • A collection of lymph tissue located in the nasopharynx. (
  • It moves from the tissue to lymph nodes, where it encounters and activates T cells. (
  • Review smallpox vaccination history and potential contraindications to vaccination for personnel on specimen collection teams. (
  • Specimen collection from suspected cases of smallpox should be conducted by personnel who have been successfully vaccinated against smallpox within the past 3 years. (
  • When possible, use plastic rather than glass materials for specimen collection. (
  • Please refer to respective test for special specimen collection and delivery instructions. (
  • Instructions for filling in the Request Form are given in the section Specimen Collection and Handling - General Information. (
  • We previously demonstrated longer survival after surgical resection with a lymph node specimen collection kit, published in the Journal of Thoracic Oncology in February, and now evaluate R-factor redistribution as the mechanism of its survival benefit,' Smeltzer said. (
  • Surgical removal of underarm (axillary) lymph nodes is often part of the initial surgical treatment for patients with operable breast cancer. (
  • Moderate-quality evidence suggests that patients who have no axillary lymph nodes removed at all are at increased risk of locoregional recurrence (regrowth of cancer, in the breast, mastectomy scar area or underarm glands). (
  • In breast cancer, the sentinel node is often one of the lymph nodes in the armpit (the axillary lymph nodes). (
  • Mapping mononuclear phagocytes in blood, lungs, and lymph nodes of sarcoidosis patients. (
  • Leptotrichiaceae, Mycoplasma, Pasteurellaceae , and Fusobacterium were the most abundant OTUs identified in the lungs and lymph nodes of the calves which died from BRD. (
  • 1996) and lungs and lymph nodes from COPD and non-COPD patients. (
  • The microbiomes of the cranial lung lobe and mediastinal lymph node from calves which died from BRD and from clinically healthy H-F calves have been characterised. (
  • Background The knowledge of the mediastinal lymph node positions from an intrabronchial view was important for conventional transbronchial needle aspiration (TBNA). (
  • 6 Moreover, because the sentinel lymph node in cervical cancer is primarily in the pelvis and standard radiation therapy fields encompass this area of potential spread, there is little clinical role for its use in the management of advanced disease. (
  • Some lymph nodes are located deeper within the body at the chest (between the two lobes of the lungs), around the coils of the intestines, in the pelvis etc. (
  • Collection of lymph fluid in the pelvis (lymphocele). (
  • The cancer has spread to lymph nodes in the abdomen or pelvis but not to more distant lymph nodes, such as those inside the chest. (
  • Unlike the blood, the interstitial fluid and the deriving lymph are directly bathing the cellular layer of each organ. (
  • Lymph is derived from the ultrafiltrate of plasma proteins and molecules, as well as from the extracellular fluid that bathes each parenchymal organ ( 1 - 7 ). (
  • Our studies showed that the mesenteric lymph duct ligation (MLDL) could alleviate kidney injury following two-hit of hemorrhage and lipopolysaccharide and hemorrhagic shock with fluid resuscitation [ 8 , 9 ]. (
  • Surgical removal of lymph nodes can lead to short-term surgical complications (such as infection and wound healing problems) and long-term problems (such as shoulder stiffness, pain and arm swelling ( lymphoedema )) when fluid accumulation causes restricted function and discomfort. (
  • The lymphatic system is basically a channel that carries a clear or whitish fluid called the lymph. (
  • They collect and move lymph fluid away from tissues into the lymph nodes. (
  • The lymph fluid can carry cancer cells from where the cancer started into the lymph nodes. (
  • Lymph fluid from tissues in the groin area drains into the lymph nodes in the groin. (
  • The lymph fluid can carry cancer cells from cancers in the groin into the inguinal lymph nodes. (
  • What is the fluid and particles absorbed into lymph capillaries? (
  • Does lymph fluid contain erythrocytes? (
  • The lymph nodes are small round organs that filter the lymph fluid. (
  • N stands for lymph nodes, which are collection areas for lymphatic fluid. (
  • Seroma is a collection of serous fluid that contains blood plasma and/ or lymph fluid. (
  • The presence of metastatic cells in the slices of lymph nodes was evaluated by immunohistochemistry using antibodies for CK19 and MMP-9. (
  • of metastatic lymph node involvement is a, the size of the node. (
  • metastatic disease in regional, that is the thoracic lymph node. (
  • 3.4.2 Patterns of Metastatic Spread to Mediastinal Lymph Nodes. (
  • Lymph carries the "omic," vesicular, and immune cell signature of the draining organs. (
  • The lymph cellular fraction is predominantly composed of immune cells, which after patrolling parenchymal organs, enter the lymphatic capillaries and collectors to travel to the draining lymph node ( 14 ). (
  • The lymph nodes, lymph and other organs. (
  • The cancer has spread through the blood to organs away from the kidneys such as the lungs, liver, brain, or bones, or to lymph nodes far away from the kidneys. (
  • Once my thyroid gland was removed in the first surgery, calcified was the term used to describe the cancerous lymph nodes found like little pebbles in my neck. (
  • The removal and examination of the cancerous lymph nodes will determine the exact stage and grade of the cancer and may reduce the spread of the disease. (
  • Removal of the cancerous lymph nodes may reduce the spread of cancer. (
  • Inguinal lymph nodes and lymphatic ducts of the legs, shown in situ, in 2 numbered illustrations. (
  • The lymph nodes in the groin are called inguinal lymph nodes. (
  • In more advanced stages of cancer, you may feel a lump in the groin as the inguinal lymph nodes get bigger. (
  • Cancer of the penis, vulva, anus and skin may spread to the inguinal lymph nodes. (
  • The surgeon makes a cut (incision) in the groin and removes inguinal lymph nodes that may contain cancer. (
  • Peripheral, abdominal, or thoracic lymph nodes were collected intra-operatively or immediately post-euthanasia from 19 canine patients. (
  • The lymph channels eventually drain at a large lymphatic vessel called the thoracic duct at the chest that drains into a blood vessel. (
  • atomic classification of the thoracic lymph nodes. (
  • Resection of all stained lymph nodes is not recommended. (
  • Determine whether the immunohistochemical and molecular presence of micrometastases in ≥ 12 lymph nodes removed during en-bloc resection in patients with stage II colon cancer correlates with 3-year disease-free survival. (
  • One of the most common places to find swollen lymph nodes is in the neck. (
  • The inset shows three swollen lymph nodes below the lower jaw. (
  • Your lymph nodes in your groin under your arms and in your neck and back of neck are all enlarged not enormous but swollen a bit you have had a cbc that came back normal Is HIV the only other thing? (
  • The reason is that glands, or lymph nodes, become swollen for different reasons. (
  • Within two weeks of the blister's appearance, lymph nodes near the site of injury become swollen. (
  • The symptoms usually disappear within a month, although the lymph nodes may remain swollen for several months. (
  • In such cases, a small sore develops on the palpebral conjunctiva (the membrane lining the inner eyelid) and is often accompanied by conjunctivitis (inflammation of the membrane) and swollen lymph nodes in front of the ear. (
  • The appearance of painful and swollen lymph nodes is another reason for consulting a doctor. (
  • When cat-scratch disease is suspected, the doctor will ask about a history of exposure to cats and look for evidence of a cat scratch or bite and swollen lymph nodes. (
  • Antibiotics are prescribed in some cases, particularly when complications occur or the lymph nodes remain swollen and painful for more than two or three months, but there is no agreement among doctors about when and how they should be used. (
  • If a lymph node becomes very swollen and painful, the family doctor may decide to drain it. (
  • Of the 39 patients, 28 (71.8%) had positive cervical lymph nodes (pN+), and 21 patients (53.8%) had pSLN+. (
  • Recent studies have suggested that the sites of extrapulmonary tuberculosis are lymph nodes in the neck, the bones, the serous membranes, and the cervical region. (
  • The purpose of this review was to assess the available literature on the effectiveness and safety of pre-treatment surgical para-aortic lymph node assessment for locally advanced cervical cancer. (
  • From the one available RCT we found insufficient evidence that pre-treatment surgical para-aortic lymph node assessment for locally advanced cervical cancer is beneficial, and it may actually have an adverse effect on survival. (
  • Therefore, the decision to offer surgical pre-treatment assessment of para-aortic lymph nodes in locally advanced cervical cancer needs to be individualised. (
  • To evaluate the effectiveness and safety of pre-treatment surgical para-aortic lymph node assessment for woman with locally advanced cervical cancer (FIGO stage IB2 to IVA). (
  • Cervical lymph node involvement, in head and cancer neck patients, is one of the most important prognostic factors. (
  • Lymph channels from the face, head and scalp drain at the nodes present at the back of the head, behind the ears and sides of the neck. (
  • Other common symptoms include large lymph nodes in the neck, a rash in the genital area, lips, palms, or soles of the feet, and red eyes. (
  • The kit includes 12 anatomically pre-labelled specimen containers and a checklist to indicate certain lymph node stations mandated for examination. (
  • If cancer cells are found in certain lymph nodes that were removed in an earlier surgical procedure. (
  • The lymph nodes are small bean shaped glands or bulbs that tend to occur in clusters much like grapes. (
  • Raise an immune reaction and fight infections - The lymphatic system especially the lymph nodes are over active in case of an infection the lymph nodes or glands often swell up in case of a local infection. (
  • Lymph nodes are bean-sized collections of immune cells. (
  • Nearby lymph nodes (bean-sized collections of immune cells) do not contain cancer. (
  • Examples comparing the detection of positive lymph nodes using the three imaging methods are shown in Figure 1 , Figure 2 , Figure 3 and Figure 4 . (
  • Diagnostic techniques for Bartonella -related infections include culture of the pathogen ( 4 , 5 ), detection of organisms in lymph nodes by immunofluorescence ( 6 ), molecular techniques including PCR amplification of Bartonella spp. (
  • Accurate detection of involved para-aortic lymph nodes helps to tailor radiotherapy so that it includes this area (extended-field radiotherapy). (
  • In order to reduce false negative rates and increase the detection rate, several surgeons may remove additional lymph nodes that are not true SLNs ( 11 , 12 ). (
  • Using luminescent conjugated polymers for histochemical PrP(Sc) detection, we identified PrP(Sc) deposits associated with HEVs in TNFR1(-/-) lymph nodes. (
  • Retrieval of an inadequate number of lymph nodes in the surgical specimen may result in incorrectly designating some patients as stage II (node negative), and consequently, such patients may not be offered appropriate chemotherapy. (
  • This review aimed to compare the benefits of surgical removal of underarm lymph nodes with the potential harms associated with this surgical procedure. (
  • Although magnetic resonance imaging and computed tomography are commonly used for lymph node assessment, the authors found that they were less effective (positive likelihood ratio for magnetic resonance imaging 6.4 and for computed tomography 4.3). (
  • The resulting infection causes swelling of appendix and collection of mucus. (
  • Adenoidectomy may be recommended when tympanostomy tube surgery ( failed to prevent ear infection. (
  • This lymph aids in clearing the tissues of infective organisms, toxins etc. (
  • This plasma bathes the tissues and enters the lymphatic channels as lymph. (
  • The uncertainty regarding any impact on survival from pre-treatment para-aortic lymph node assessment should be discussed openly with the women. (
  • A subset of patients with CRC in Ontario were assigned stage II disease on the basis of examination of relatively few lymph nodes. (
  • For patients with Dukes' B (TNM stage II) colorectal carcinoma, examination of six or fewer lymph nodes is related to poor prognosis. (
  • If cancer has spread to these lymph nodes , patients are advised to undergo additional treatments, such as chemotherapy or radiotherapy, to help treat their disease. (
  • If cancer has not spread to these lymph nodes , patients are spared extra treatments (with extra side effects). (
  • lymph nodes in the thorax in patients with non-small cell lung cancer. (
  • Some of these patients may have general, vascular or obstructive uropathy repercussions that are secondary to the collection, so it is necessary to study the cause. (
  • This helps in the movement of the immunity producing cells called lymphocytes (type of white blood cells), and the toxins, germs and chemicals to move in to the lymph capillaries freely. (
  • RATIONALE: Diagnostic procedures that look for micrometastases in lymph nodes removed during surgery for colon cancer may help doctors learn the extent of disease. (
  • Direct in vivo imaging of lymph flow is key to understanding lymphatic system function in normal and disease states. (
  • The second phase of the thesis aims to characterize the detectability of the choline metabolite in canine lymph nodes ex vivo, and compare choline ii levels (via choline signal-to-noise ratio or Cho SNR) among populations of normal, reactive, and malignant lymph nodes. (
  • Our hypothesis was that choline would be detectable in canine lymph nodes ex vivo, and that the Cho SNR in malignant lymph nodes would be significantly higher than in normal and reactive lymph nodes. (
  • Figures 1 and 2 show examples of Russell bodies in an enlarged lymph node in vivo in an AIDS case. (