Collectins: A class of C-type lectins that target the carbohydrate structures found on invading pathogens. Binding of collectins to microorganisms results in their agglutination and enhanced clearance. Collectins form trimers that may assemble into larger oligomers. Each collectin polypeptide chain consists of four regions: a relatively short N-terminal region, a collagen-like region, an alpha-helical coiled-coil region, and carbohydrate-binding region.Pulmonary Surfactant-Associated Protein D: An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.Pulmonary Surfactant-Associated Protein A: An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.Serum Globulins: All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)Pulmonary Surfactant-Associated Proteins: Proteins found in the LUNG that act as PULMONARY SURFACTANTS.Pulmonary Surfactants: Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.Mannose-Binding Lectin: A specific mannose-binding member of the collectin family of lectins. It binds to carbohydrate groups on invading pathogens and plays a key role in the MANNOSE-BINDING LECTIN COMPLEMENT PATHWAY.Proteolipids: Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.Mannans: Polysaccharides consisting of mannose units.Lectins: Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.Complement C1q: A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.Opsonin Proteins: Proteins that bind to particles and cells to increase susceptibility to PHAGOCYTOSIS, especially ANTIBODIES bound to EPITOPES that attach to FC RECEPTORS. COMPLEMENT C3B may also participate.Hemagglutination: The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).Macrophages, Alveolar: Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.Influenza A virus: The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.Hemagglutination Inhibition Tests: Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Monosaccharides: Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)Carbohydrates: The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.Phagocytosis: The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Mycobacterium avium: A bacterium causing tuberculosis in domestic fowl and other birds. In pigs, it may cause localized and sometimes disseminated disease. The organism occurs occasionally in sheep and cattle. It should be distinguished from the M. avium complex, which infects primarily humans.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Immunity, Innate: The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.Surface Plasmon Resonance: A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.Respiratory Mucosa: The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.Glycosylation: The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Catalogs, LibraryCatalogs as Topic: Ordered compilations of item descriptions and sufficient information to afford access to them.Idiopathic Pulmonary Fibrosis: A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.Agglutinins: Substances, usually of biological origin, that cause cells or other organic particles to aggregate and stick to each other. They include those ANTIBODIES which cause aggregation or agglutination of particulate or insoluble ANTIGENS.Receptors, Scavenger: A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. They can also bind a variety of other polyanionic ligand. Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells.Scavenger Receptors, Class B: A family of scavenger receptors that are predominately localized to CAVEOLAE of the PLASMA MEMBRANE and bind HIGH DENSITY LIPOPROTEINS.Receptors, Pattern Recognition: A large family of cell surface receptors that bind conserved molecular structures (PAMPS) present in pathogens. They play important roles in host defense by mediating cellular responses to pathogens.Receptors, Immunologic: Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere.Zona Pellucida: A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.Streptococcus mutans: A polysaccharide-producing species of STREPTOCOCCUS isolated from human dental plaque.Internal Capsule: WHITE MATTER pathway, flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the WHITE MATTER and the BRAINSTEM. It consists of three distinct parts: an anterior limb, posterior limb, and genu.Strigiformes: An order of BIRDS with the common name owls characterized by strongly hooked beaks, sharp talons, large heads, forward facing eyes, and facial disks. While considered nocturnal RAPTORS, some owls do hunt by day.RussiaKyrgyzstanNeuroendocrine Tumors: Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.Ozone: The unstable triatomic form of oxygen, O3. It is a powerful oxidant that is produced for various chemical and industrial uses. Its production is also catalyzed in the ATMOSPHERE by ULTRAVIOLET RAY irradiation of oxygen or other ozone precursors such as VOLATILE ORGANIC COMPOUNDS and NITROGEN OXIDES. About 90% of the ozone in the atmosphere exists in the stratosphere (STRATOSPHERIC OZONE).Airway Obstruction: Any hindrance to the passage of air into and out of the lungs.Feedback, Physiological: A mechanism of communication with a physiological system for homeostasis, adaptation, etc. Physiological feedback is mediated through extensive feedback mechanisms that use physiological cues as feedback loop signals to control other systems.Beer: An alcoholic beverage usually made from malted cereal grain (as barley), flavored with hops, and brewed by slow fermentation.Laryngocele: Congenital anomalous dilitation of the laryngeal saccule that may extend internally into the airway or externally through the thyrohyoid membrane.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Reagent Kits, Diagnostic: Commercially prepared reagent sets, with accessory devices, containing all of the major components and literature necessary to perform one or more designated diagnostic tests or procedures. They may be for laboratory or personal use.Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Chickens: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.Reindeer: A genus of deer, Rangifer, that inhabits the northern parts of Europe, Asia, and America. Caribou is the North American name; reindeer, the European. They are often domesticated and used, especially in Lapland, for drawing sleds and as a source of food. Rangifer is the only genus of the deer family in which both sexes are antlered. Most caribou inhabit arctic tundra and surrounding arboreal coniferous forests and most have seasonal shifts in migration. They are hunted extensively for their meat, skin, antlers, and other parts. (From Webster, 3d ed; Walker's Mammals of the World, 5th ed, p1397)Alphaherpesvirinae: A subfamily of HERPESVIRIDAE characterized by a short replication cycle. The genera include: SIMPLEXVIRUS; VARICELLOVIRUS; MAREK'S DISEASE-LIKE VIRUSES; and ILTOVIRUS.

Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene. (1/252)

Mannan-binding lectin (MBL) forms a multimolecular complex with at least two MBL-associated serine proteases, MASP-1 and MASP-2. This complex initiates the MBL pathway of complement activation by binding to carbohydrate structures present on bacteria, yeast, and viruses. MASP-1 and MASP-2 are composed of modular structural motifs similar to those of the C1q-associated serine proteases C1r and C1s. Another protein of 19 kDa with the same N-terminal sequence as the 76-kDa MASP-2 protein is consistently detected as part of the MBL/MASP complex. In this study, we present the primary structure of this novel MBL-associated plasma protein of 19 kDa, MAp19, and demonstrate that MAp19 and MASP-2 are encoded by two different mRNA species generated by alternative splicing/polyadenylation from one structural gene.  (+info)

C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity. (2/252)

C1q, mannose-binding lectin (MBL), and pulmonary surfactant protein A (SPA) interact with human monocytes and macrophages, resulting in the enhancement of phagocytosis of suboptimally opsonized targets. mAbs that recognize a cell surface molecule of 126,000 Mr, designated C1qRP, have been shown to inhibit C1q- and MBL-mediated enhancement of phagocytosis. Similar inhibition of the SPA-mediated enhancement of phagocytosis by these mAbs now suggests that C1qRP is a common component of a receptor for these macromolecules. Ligation of human monocytes with immobilized R3, a IgM mAb recognizing C1qRP, also triggers enhanced phagocytic capacity of these cells in the absence of ligand, verifying the direct involvement of this polypeptide in the regulation of phagocytosis. While the cDNA for C1qRP encodes a 631 amino acid membrane protein, Chinese hamster ovary cells transfected with the cDNA of the C1qRP coding region express a surface glycoprotein with the identical 126,000 Mr in SDS-PAGE as the native C1qRP. Use of glycosylation inhibitors, cleavage of the mature C1qRP with specific glycosidases, and in vitro translation of C1qRP cDNA demonstrated that both posttranslational glycosylation and the nature of the amino acid sequence of the protein contribute to the difference between its predicted m.w. and its migration on SDS-PAGE. These results verify that the cDNA cloned codes for the mature C1qRP, that C1qRP contains a relatively high degree of O-linked glycoslyation, and that C1qRP cross-linked directly by monoclonal anti-C1qRP or engaged as a result of cell surface ligation of SPA, as well as C1q and MBL, enhances phagocytosis.  (+info)

KM+, a mannose-binding lectin from Artocarpus integrifolia: amino acid sequence, predicted tertiary structure, carbohydrate recognition, and analysis of the beta-prism fold. (3/252)

The complete amino acid sequence of the lectin KM+ from Artocarpus integrifolia (jackfruit), which contains 149 residues/mol, is reported and compared to those of other members of the Moraceae family, particularly that of jacalin, also from jackfruit, with which it shares 52% sequence identity. KM+ presents an acetyl-blocked N-terminus and is not posttranslationally modified by proteolytic cleavage as is the case for jacalin. Rather, it possesses a short, glycine-rich linker that unites the regions homologous to the alpha- and beta-chains of jacalin. The results of homology modeling implicate the linker sequence in sterically impeding rotation of the side chain of Asp141 within the binding site pocket. As a consequence, the aspartic acid is locked into a conformation adequate only for the recognition of equatorial hydroxyl groups on the C4 epimeric center (alpha-D-mannose, alpha-D-glucose, and their derivatives). In contrast, the internal cleavage of the jacalin chain permits free rotation of the homologous aspartic acid, rendering it capable of accepting hydrogen bonds from both possible hydroxyl configurations on C4. We suggest that, together with direct recognition of epimeric hydroxyls and the steric exclusion of disfavored ligands, conformational restriction of the lectin should be considered to be a new mechanism by which selectivity may be built into carbohydrate binding sites. Jacalin and KM+ adopt the beta-prism fold already observed in two unrelated protein families. Despite presenting little or no sequence similarity, an analysis of the beta-prism reveals a canonical feature repeatedly present in all such structures, which is based on six largely hydrophobic residues within a beta-hairpin containing two classic-type beta-bulges. We suggest the term beta-prism motif to describe this feature.  (+info)

Molecular cloning of a novel human collectin from liver (CL-L1). (4/252)

Collectins are a C-lectin family with collagen-like sequences and carbohydrate recognition domains. These proteins can bind to carbohydrate antigens of microorganisms and inhibit their infection by direct neutralization and agglutination, the activation of complement through the lectin pathway, and opsonization by collectin receptors. Here we report the cloning of a cDNA encoding human collectin from liver (CL-L1 (collectin liver 1)) that has typical collectin structural characteristics, consisting of an N-terminal cysteine-rich domain, a collagen-like domain, a neck domain, and a carbohydrate recognition domain. The cDNA has an insert of 831 base pairs coding for a protein of 277 amino acid residues. The deduced amino acid sequence shows that this collectin has a unique repeat of four lysine residues in its C-terminal area. Northern blot, Western blot, and reverse transcription-polymerase chain reaction analyses showed that CL-L1 is present mainly in liver as a cytosolic protein and at low levels in placenta. More sensitive analyses by reverse transcription-polymerase chain reactions showed that most tissues (except skeletal muscle) have CL-L1 mRNA. Zoo-blot analysis indicated that CL-L1 is limited to mammals and birds. A chromosomal localization study indicated that the CL-L1 gene localizes to chromosome 8q23-q24.1, different from chromosome 10 of other human collectin genes. Expression studies of fusion proteins lacking the collagen and N-terminal domains produced in Escherichia coli affirmed that CL-L1 binds mannose weakly. CL-L1 and recombinant CL-L1 fusion proteins do not bind to mannan columns. Analysis of the phylogenetic tree of CL-L1 and other collectins indicated that CL-L1 belongs to a fourth subfamily of collectins following the mannan-binding protein, surfactant protein A, and surfactant protein D subfamilies including bovine conglutinin and collectin-43 (CL-43). These findings indicate that CL-L1 may be involved in different biological functions.  (+info)

Isolation, characterization, molecular cloning and molecular modelling of two lectins of different specificities from bluebell (Scilla campanulata) bulbs. (5/252)

Two lectins have been isolated from bluebell (Scilla campanulata) bulbs. From their isolation by affinity chromatography, they are characterized as a mannose-binding lectin (SCAman) and a fetuin-binding lectin (SCAfet). SCAman preferentially binds oligosaccharides with alpha(1,3)- and alpha(1,6)-linked mannopyranosides. It is a tetramer of four identical protomers of approx. 13 kDa containing 119 amino acid residues; it is not glycosylated. The fetuin-binding lectin (SCAfet), which is not inhibited by any simple sugars, is also unglycosylated. It is a tetramer of four identical subunits of approx. 28 kDa containing 244 residues. Each 28 kDa subunit is composed of two 14 kDa domains. Both lectins have been cloned from a cDNA library and sequenced. X-ray crystallographic analysis and molecular modelling studies have demonstrated close relationships in sequence and structure between these lectins and other monocot mannose-binding lectins. A refined model of the molecular evolution of the monocot mannose-binding lectins is proposed.  (+info)

Glomerular deposition of mannose-binding lectin in human glomerulonephritis. (6/252)

BACKGROUND: Mannose-binding lectin (MBL), a member of the collectin family, binds to various oligosaccharides and activates the classical pathway of complement independent from C1q. At present it is unknown whether this so-called lectin pathway of complement activation plays a role in the pathogenesis of human glomerulonephritis. METHODS: Direct immunofluorescence of 84 renal biopsies using an MBL-specific monoclonal antibody and antibodies directed against IgG, IgA, IgM, C1q, C3, and terminal complement complex (TCC) was performed. Serum MBL levels of 50 patients were determined by enzyme-linked immunosorbent assay. RESULTS: MBL was detected in the glomeruli of patients with lupus nephropathy (15 of 16), membranous nephropathy (10/15), membranoproliferative glomerulonephritis type I (5/6) and anti-GBM nephritis (2/4). MBL deposition paralleled that of immunoglobulins, C1q, C3, and TCC but was less intense as compared to C1q. Focal segmental deposits of MBL were present in focal segmental glomerulosclerosis (4/6), IgA nephropathy (3/11), amyloidosis AL (1/4), and advanced renal fibrosis (2/2). Here MBL staining was identical to IgM and C3 and considered an unspecific entrapment of MBL in sclerotic lesions in these cases. No significant difference in MBL serum levels was observed between normal controls and patients with lupus nephritis, membranous nephropathy, membranoproliferative glomerulonephritis, focal segmental sclerosis, minimal change disease or IgA nephropathy. In patients suffering from membranous nephropathy with (n=10) or without (n=5) glomerular MBL deposits serum creatinine, C3, C4, serum protein, and proteinuria were not statistically different. CONCLUSION: MBL is present in the glomeruli of patients with glomerulonephritis involving deposition of IgG and activation of the classical pathway of complement. We propose that MBL binds to agalactosyl oligosaccharides of IgG that terminate in N-acetylglucosamine. The extent to which the lectin pathway of complement contributes to overall complement activation in the glomeruli remains unknown, but is likely to be marginal.  (+info)

The significance of IgG subclasses and mannan-binding lectin (MBL) for susceptibility to infection in apparently healthy adults with IgA deficiency. (7/252)

The aim of this study was to investigate the significance of IgG subclasses and MBL for susceptibility to infection in association with IgA deficiency. The study population consisted of 139 apparently healthy adult blood donors with IgA deficiency and normal serum levels of IgG and IgM, and an increased susceptibility to infection demonstrated at a population level. Additionally, 216 controls matched for age and sex were investigated. IgG4 deficiency was more common and the mean level of IgG4 lower in persons with IgA deficiency than in the controls. No significant associations could be demonstrated between overt IgG subclass deficiencies and increased susceptibility to infection. However, when the mean concentrations of IgG subclasses were analysed with regard to medical history, that of IgG1 was lower in persons who reported recurrent viral respiratory infections, that of IgG3 in persons who had episodes of severe infection in their history, and that of IgG4 in persons who had recurrent mild respiratory infections, compared with those who had no particular history of infections. In contrast, MBL deficiency-alone or combined with that of the IgG subclass-was not associated with increased susceptibility to infection in persons with IgA deficiency. The results indicate that the proneness to infections observed in a population of otherwise healthy persons with IgA deficiency can only for a small part be accounted for by concomitant deficiencies of IgG subclasses. Contrary to expectations, no synergism between the deficiencies of IgA and MBL could be demonstrated.  (+info)

Antibody-independent classical complement pathway activation and homologous C3 deposition in xeroderma pigmentosum cell lines. (8/252)

Of human malignantly transformed cell lines, xeroderma pigmentosum (XP) cell lines were found to be highly susceptible to homologous complement (C): cells were opsonized by C3 fragments on incubation with diluted normal human serum. C3 fragment deposition on XP cells was Ca2+-dependent and occurred on live cells but not UV-irradiated apoptotic cells. (Ca2+ is required for activation of the classical C pathway via C1q and the lactin pathway via mannose binding lectin (MBL), and the surface of apoptotic cells usually activates the alternative C pathway.) In this study we tested which of the pathways participates in XP cell C3 deposition. In seven cell lines that allowed C3 deposition (i), Clq was shown to be essential but MBL played no role in C activation, (ii) Cls but not MASP bound XP cells for activation, (iii) no antibodies recognizing XP cells were required for homologous C3 deposition, and (iv) the alternative pathway barely participated in C3 deposition. Furthermore, the levels of C-regulatory proteins for host cell protection against C, decay-accelerating factor (DAF, CD55) and membrane cofactor protein (MCP, CD46), were found to be relatively low in almost all XP cell lines compared with normal cells. These results indicate that XP cells activate the classical C pathway in an antibody-independent manner through the expression of a molecule which directly attracts C1q in a C-activating form, and that relatively low levels of DAF and MCP on XP cells facilitate effective C3 deposition. The possible relationship between the pathogenesis of XP and our findings is discussed.  (+info)

Download Free Full-Text of an article Serum mannan-binding lectin in patients with pulmonary tuberculosis: Its lack of a relationship to the disease and response to treatment
Collectins such as mannose-binding lectin (MBL) and surfactant protein D (SP-D) become temporarily deposited in extravascular compartments after tissue injury and perform immune-stimulatory or inflammation-limiting functions. However, their turnover mechanisms, necessary to prevent excessive tissue damage, are virtually unknown. In this study, we show that fibroblasts in injured tissues undertake the clearance of collectins by using the endocytic collagen receptor uPARAP. In cellular assays, several types of collectins were endocytosed in a highly specific uPARAP-dependent process, not shared by the closely related receptor MR/CD206. When introduced into dermis or bleomycin-injured lungs of mice, collectins MBL and SP-D were endocytosed and routed for lysosomal degradation by uPARAP-positive fibroblasts. Fibroblast-specific expression of uPARAP governed endogenous SP-D levels and overall survival after lung injury. In lung tissue from idiopathic pulmonary fibrosis patients, a strong ...
Collectins are oligomeric proteins composed of C type lectin domains connected to collagen regions (1). Three collectins are known in humans: mannan-binding lectin (MBL), a serum protein, and the lung surfactant proteins A and D (SP-A and SP-D), which are produced by epithelial cells mainly in the lung. The collectins play an important role in innate immunity by binding to specific carbohydrate structures found on the surfaces of pathogenic microorganisms, including bacteria, viruses, yeasts, and parasitic protozoa. The binding promotes effector mechanisms such as aggregation, hindrance of infection, activation of phagocytes, and initiation of phagocytosis. After binding to microbial surfaces, MBL activates the complement system through a complement activation pathway, the MBL pathway, by using two recently identified serine proteases, MASP-1 and MASP-2, to activate C4 and C2 (2).. SP-D is mainly produced by alveolar type II cells but is also present in sweat, salivary, tear, and mammary glands ...
(= MBL; formerly mannan binding protein, MBP) Plasma protein (32 kD) structurally related to complement C1, that binds specific carbohydrates (mannans) on the surface of various microorganisms including bacteria, yeasts, parasitic protozoa, and…
Rynkiewicz MJ, Wu H, Cafarella TR, Nikolaidis NM, Head JF, Seaton BA, McCormack FX. (2017) Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop. Biochemistry. Aug 8; 56(31):4095-4105. PMID: 28719181.. Rynkiewicz MJ, Fischer S, Lehman W. (2016) The propensity for tropomyosin twisting in the presence and absence of F-actin. Arch Biochem Biophys. 2016 Nov 1; 609:51-58. PMID: 27663225.. Goh BC, Wu H, Rynkiewicz MJ, Schulten K, Seaton BA, McCormack FX. (2016) Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations. Biochemistry. 2016 Jul 5; 55(26):3692-701. PMID: 27324153.. Fischer S, Rynkiewicz MJ, Moore JR, Lehman W. (2016) Tropomyosin diffusion over actin subunits facilitates thin filament assembly. Struct Dyn. 2016 Jan 14; 3(1):012002. PMID: 26798831.. Rynkiewicz MJ, Schott V, Orzechowski M, Lehman W, Fischer S. (2015) Electrostatic ...
Principal Investigator:KAWASAKI Nobuko, Project Period (FY):1993 - 1994, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Biological pharmacy
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TY - JOUR. T1 - Reaction of Bovine Conglutinin in Human in Vitro Phagocytic Systems. AU - Kronvall, Göran. AU - Dossett, John. AU - Quie, Paul G.. AU - Williams, Ralph C.. PY - 1970/1/1. Y1 - 1970/1/1. N2 - Bovine conglutinin, a naturally occurring anti-C3 factor, was studied in quantitative human in vitro phagocytosis systems. Striking antiopsonic effect was noted when conglutinin was added to phagocytic systems with gram-negative and gram-positive organisms dependent on heat-labile opsonic factors. In noncomplement-dependent test systems using isolated hyperimmune γG opsonins, no blocking by conglutinin was noted.. AB - Bovine conglutinin, a naturally occurring anti-C3 factor, was studied in quantitative human in vitro phagocytosis systems. Striking antiopsonic effect was noted when conglutinin was added to phagocytic systems with gram-negative and gram-positive organisms dependent on heat-labile opsonic factors. In noncomplement-dependent test systems using isolated hyperimmune γG ...
To investigate the point mutation at codon 54 of mannose binding lectin (MBL) gene, detect the plasma MBL level, and analyze the correlation between the gene mutation frequency and plasma MBL concentration. A method for detecting MBL gene point mutation (PCR-RFLP) was established with self-designed primers according to MBL genomic sequence. The plasma MBL concentration was detected by MBL Oliger ELISA kit. The PCR-RFLP for detecting the point mutation at codon 54 of MBL gene was established. Frequency of point mutation at codon 54 of MBL gene in healthy Mongolians was 0.18. The plasma MBL concentration was (2.53+/-1.96)mg/L. There was negative correlation between plasma MBL concentration and MBL gene mutation frequency in Mongolians (r = -0.641). The established method of PCR-RFLP was proved to have high specificity, excellent reproducibility and high sensitivity. The relationship between frequency of mutation at codon 54 of MBL gene and the plasma MBL concentration in healthy Mongolians is ...
RATIONALE: Recombinant human mannose-binding lectin (MBL) may be effective in preventing infection in young patients with fever and neutropenia receivin
Structural variants of the Mannose Binding Lectin (MBL) cause quantitative and qualitative functional deficiencies, which are associated with various patterns of susceptibility to infectious diseases and other disorders. We determined genetic MBL variants in 2010 Ghanaian patients with pulmonary tuberculosis (TB) and 2346 controls and characterized the mycobacterial isolates of the patients. Assuming a recessive mode of inheritance, we found a protective association between TB and the MBL2 G57E variant (odds ratio 0.60, confidence interval 0.4-0.9, P 0.008) and the corresponding LYQC haplotype (Pcorrected 0.007) which applied, however, only to TB caused by M. africanum but not to TB caused by M. tuberculosis. In vitro, M.africanum isolates bound recombinant human MBL more efficiently than did isolates of M. tuberculosis. We conclude that MBL binding may facilitate the uptake of M. africanum by macrophages, thereby promoting infection and that selection by TB may have favoured the spread of ...
This unit contains protocols that can be used to measure mannan‐binding lectin (MBL) levels and MBL pathway activity in human plasma or serum
Recently, an association between the presence of antibodies to Saccharomyces cerevisiae (ASCA) and mutations in exon 1 and the promoter region of the mannan binding lectin (MBL) gene was described in 58 patients with Crohns disease (CD).1 A possible link between ASCA and MBL mutations in patients with CD is plausible. MBL is a component of the innate immune system that can bind to S cerevisiae and the serum concentration of MBL … ...
With enhanced promotor, Mannan Binding Lectin / MBL2 cDNA ORF Clone, Mouse in pCMV3-C-OFPSpark is expression-ready, and confirmed by full-length sequence & expression validation
Your trusted lab partner for Mannan Binding Lectin (MBL) testing, Viracor Eurofins delivers your results faster, when it matters most.
Mannose binding lectin (MBL) is an important host defence protein against opportunistic fungal pathogens. This carbohydrate-binding protein, an opsonin and lectin pathway activator, binds through multiple lectin domains to the repeating sugar arrays displayed on the surface of a wide range of clinically relevant microbial species. We investigated the contribution of MBL to antifungal innate immunity towards C. parapsilosis in vitro. High avidity binding was observed between MBL and C. albicans and C. parapsilosis. Addition of MBL to MBL deficient serum increased the deposition of C4 and C3b and enhanced the uptake of C. albicans, C. parapsilosis and acapsular C. neoformans by polymorphonuclear cells (PMNs). Compared to other microorganisms, such as Escherichia coli, Staphylococcus aureus and Cryptococcus neoformans, C. parapsilosis and Candida albicans were potent activators of the lectin pathway. Our results suggest that MBL plays a crucial role in the innate immunity against infections caused by yeast
Individuals with low levels of mannan-binding lectin (MBL) appear to be susceptible to infectious diseases. This suggests that substitution therapy with MBL might be a beneficial treatment of patients with MBL deficiency. A production process for an MBL product has been developed from a fraction II+III precipitate obtained by ethanol fractionation of plasma. The MBL process includes three chromatographic steps, where the first and key step is affinity chromatography on a cross-linked agarose matrix selecting for oligomeric, carbohydrate-binding MBL. The yield from the production process is about 25% of the plasma MBL content, and the purity is about 65%. The MBL product shows mannan-binding activity and complement-activating ability. A safety study has shown this plasma-derived MBL to be safe and well tolerated in adult MBL-deficient volunteers. ...
Research abstract: Chronic fatigue syndrome (CFS) is a severe disease characterized by various symptoms of immune dysfunction. CFS onset is typically with an infection and many patients suffer from frequently recurrent viral or bacterial infections. Immunoglobulin and mannose binding lectin … Continue reading →. ...
Atherosclerosis is a chronic inflammatory disorder that is characterized by the accumulation of modified lipoproteins in the arterial intima. C1q and mannan-binding lectin (MBL) are not only recognition components involved in activation of inflammation via the complement cascade, but they are also able to directly modulate phagocyte activation. Studies in C1q−/− and MBL−/− mice suggest that these molecules play a protective role in the early atherosclerotic lesion in the absence of, or prior to, expression of other complement components. However, in later stages, complement activation becomes an inappropriate inflammatory response, contributing to disease pathology. Therefore, to investigate possible molecular interactions of C1q and MBL in atherosclerotic lesions, we examined the influence of C1q and MBL in the clearance of native and modified lipoproteins by human monocytes and monocyte-derived macrophages. Both C1q and MBL are shown to bind and enhance the monocyte/monocyte-derived ...
Mannose molecules signal acute responses to the immune system. Mannan binding proteins are essential to recognize, signal, and activate the immune system
Looking for immune conglutinin? Find out information about immune conglutinin. A heat-stable substance in bovine and other serums that aids or causes agglomeration or lysis of certain sensitized cells or particles Explanation of immune conglutinin
TY - JOUR. T1 - Solid phase enzyme immunoassay or radioimmunoassay for the detection of immune complexes based on their recognition by conglutinin. T2 - conglutinin binding test. A comparative study with 125I labelled C1q binding and Raji cell RIA tests. AU - Casali, P.. AU - Bossus, A.. AU - Carpentier, N. A.. AU - Lambert, P. H.. PY - 1977/12/1. Y1 - 1977/12/1. N2 - Bovine conglutinin was used in a solid-phase assay for the detection of immune complexes. In a first step, the tested serum sample is incubated in polypropylene tubes coated with conglutinin to allow C3-coated immune complexes to bind to solid-phase conglutinin. In a second step, the conglutinin-bound complexes are detected using an enzyme-conjugated or radiolabelled antiimmunoglobulin antibody. The conglutinin-binding (KgB) test does not suffer from the interference of DNA, heparin or endotoxins. Its limit of sensitivity for aggregated IgG is 3 μg/ml undiluted human serum. Immune complexes prepared in vitro using tetanus toxoid, ...
Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable. Spin down and send 1 mL of serum frozen in a plastic vial.
Mannan-Binding lectin (MBL) is a serum lectin and an important constituent of the innate immune system. Processes linked to the innate immune response have previously been implicated in Alzheimers disease (AD). MBL is associated with blood vessels in the brain and AD patients demonstrate lower MBL levels in the cerebrospinal fluid compared to controls. We investigated six single nucleotide polymorphisms, linked to MBL deficiency, in the corresponding MBL2 gene in AD patients and controls. Two MBL2 haplotypes, LXP and LYQ, were significantly associated with AD risk (OR = 1.6, p = 0.01 and OR = 1.5, p = 0.02, respectively). The present study is the first investigating MBL2 genotypes and haplotypes in relation to AD. Our findings support that the MBL2 gene impact the disease risk.
ASCA can also be inherited, much like a gluten allergy is inherited in Celiacs. There appears to be a genetic predispostion in Crohns and Behcets disease. There have been several studies finding ASCA in healthy relatives of these patients. Whats more, the genetic mechanism that may be responsible is something called Mannan Binding Lectin (MBL) deficiency. Mannan Binding Lectins are a part of the Innate Immune System. They look similar to bouquets of tulips. The tulip portion is designed to latch on to the carbohydrate surface of yeasts and certain bacteria. Once latched on they can sweep the particle away or call out to other components of the immune sytem to help with disposal. Roughly 55 percent, or so, of the population has adequate MBL, about 40 percent of so are lower on MBL and roughly 5-10 percent are deficient. When an individual is low, another part of the immune system steps in to take up the slack, and its usually antibodies that do this. And if I understand correctly (again, I ...
ASCA can also be inherited, much like a gluten allergy is inherited in Celiacs. There appears to be a genetic predispostion in Crohns and Behcets disease. There have been several studies finding ASCA in healthy relatives of these patients. Whats more, the genetic mechanism that may be responsible is something called Mannan Binding Lectin (MBL) deficiency. Mannan Binding Lectins are a part of the Innate Immune System. They look similar to bouquets of tulips. The tulip portion is designed to latch on to the carbohydrate surface of yeasts and certain bacteria. Once latched on they can sweep the particle away or call out to other components of the immune sytem to help with disposal. Roughly 55 percent, or so, of the population has adequate MBL, about 40 percent of so are lower on MBL and roughly 5-10 percent are deficient. When an individual is low, another part of the immune system steps in to take up the slack, and its usually antibodies that do this. And if I understand correctly (again, I ...
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Ser Leu Ser Lys1 5 10 15Ala Ser Ala His Thr Val Glu Leu Asn Asn Met Phe Gly Gln Ile Gln 20 25 30Ser Pro Gly Tyr Pro Asp Ser Tyr Pro Ser Asp Ser Glu Val Thr Trp 35 40 45Asn Ile Thr Val Pro Asp Gly Phe Arg Ile Lys Leu Tyr Phe Met His 50 55 60Phe Asn Leu Glu Ser Ser Tyr Leu Cys Glu Tyr Asp Tyr Val Lys Val65 70 75 80Glu Thr Glu Asp Gln Val Leu Ala Thr Phe Cys Gly Arg Glu Thr Thr 85 90 95Asp Thr Glu Gln Thr Pro Gly Gln Glu Val Val Leu Ser Pro Gly Ser 100 105 110Phe Met Ser Ile Thr Phe Arg Ser Asp Phe Ser Asn Glu Glu Arg Phe 115 120 125Thr Gly Phe Asp Ala His Tyr Met Ala Val Asp Val Asp Glu Cys Lys 130 135 140Glu Arg Glu Asp Glu Glu Leu Ser Cys Asp His Tyr Cys His Asn Tyr145 150 155 160Ile Gly Gly Tyr Tyr Cys Ser Cys Arg Phe Gly Tyr Ile Leu His Thr 165 170 175Asp Asn Arg Thr Cys Arg Val Glu Cys Ser Asp Asn Leu Phe Thr Gln 180 185 190Arg Thr Gly Val Ile Thr Ser Pro Asp Phe Pro Asn Pro Tyr Pro Lys 195 200 205Ser Ser Glu Cys Leu Tyr Thr Ile Glu Leu Glu Glu Gly Phe Met Val 210 215 220Asn Leu Gln Phe Glu ...
Phagocytosis of microbes is a major innate host defense that limits the growth and spread of pathogens. Phagocytes appear rapidly at sites of infection in conjunction with the initiation of inflammation. Ingestion of microbes by both tissue-fixed macrophages and migrating phagocytes probably accounts for the limited ability of most microbial agents to cause disease.A family of related molecules called collectins, soluble defense collagens, or pattern-recognition molecules are found in blood (mannose-binding lectins), in lung (surfactant proteins A and D), and most likely in other tissues as well and bind to carbohydrates on microbial surfaces to promote phagocyte clearance. Bacterial pathogens seem to be ingested principally by polymorphonuclear neutrophils (PMNs), whereas eosinophils are frequently found at sites of infection with protozoan or multicellular parasites. Successful pathogens, by definition, must avoid being cleared by professional phagocytes. One of several antiphagocytic ...
WLAN-Repeater N Mbps, 2,4GHz Operating Instructions Bedienungsanleitung GB D Signal WLAN Power WPS LAN WPS man.indd :28 G User manual WLAN 300 Mbps Repeater Contents
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Mannan Binding Lectin (MBL) is a member of the lectin pathway of the complement system and plays an important role in the innate immune system. MBL replacement in MBL-deficient children with chemotherapy-induced neutropenia represents a new approach to lower the risk of febrile episodes, of hospital admission, of prolonged use of intravenous antibiotics and of severe infections.. The aim of the Phase II study is to find evidence for the correct prediction of plasma levels of MBL necessary for clinical effects and biological efficacy, to confirm the dosage regimen needed to reach the required MBL plasma levels, and reconfirm the safety and lack of side-effects. ...
Mannose binding lectin (MBL) is a calcium-dependent lectin that plays an important role innate immunity by activating the complement pathway. There have been a number of studies describing an association between the MBL genotype and disease susceptibility. ...
Background: There have been studies focused on mannose binding lectin (MBL) polymorphism and susceptibility to recurrent respiratory tract infections (RRTI) with inconclusive results. This present study is a meta-analysis of possible MBL and RRTI association in children. ...
The ficolins share a common organization and function with the collectins: serum mannose-binding and the pulmonary surfactant proteins A and D. All of these proteins are soluble mediators of innate immunity and consist of globular sugar-binding domains attached to collagenous stalks, which can invoke innate immune responses either through complement fixation or interaction with receptors on the surfaces of macrophages. Amongst these proteins, the ficolins have been most extensively investigated with CFG resources, while mannose-binding protein is the best characterized. The ficolins have fibrinogen-like sugar-binding domains, rather than C-type carbohydrate-recognition domains, but conceptually fall within the same group. See also: paradigm page for Ficolin M (Ficolin 1) ...
The ficolins share a common organization and function with the collectins: serum mannose-binding and the pulmonary surfactant proteins A and D. All of these proteins are soluble mediators of innate immunity and consist of globular sugar-binding domains attached to collagenous stalks, which can invoke innate immune responses either through complement fixation or interaction with receptors on the surfaces of macrophages. Amongst these proteins, the ficolins have been most extensively investigated with CFG resources, while mannose-binding protein is the best characterized. The ficolins have fibrinogen-like sugar-binding domains, rather than C-type carbohydrate-recognition domains, but conceptually fall within the same group. See also: paradigm page for Ficolin M (Ficolin 1) ...
(lek tin) The lectin pathway for complement activation is triggered by the binding of a serum lectin (mannan binding lectin; MBL) to mannose containing proteins or to carbohydrates on viruses or bacteria
The pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D), have been reported to bind lipopolysaccharide (LPS), opsonize microorganisms, and enhance the clearance of lung pathogens. In this study, we examined the effect of SP-A and SP-D on the growth and viability of Gram-negative bacteria. The pulmonary clearance of Escherichia coli K12 was reduced in SP-A-null mice and was increased in SP-D-overexpressing mice, compared with strain-matched wild-type controls. Purified SP-A and SP-D inhibited bacterial synthetic functions of several, but not all, strains of E. coli, Klebsiella pneumoniae, and Enterobacter aerogenes. In general, rough E. coli strains were more susceptible than smooth strains, and collectin-mediated growth inhibition was partially blocked by coincubation with rough LPS vesicles. Although both SP-A and SP-D agglutinated E. coli K12 in a calcium-dependent manner, microbial growth inhibition was independent of bacterial aggregation. At least part of the antimicrobial ...
Gene Information The ficolin family of proteins are characterized by the presence of a leader peptide a short N-terminal segment followed by a collagen-like region and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q C-type lectins known as collectins and tenascins. However all these proteins recognize different targets and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq Jul 2008]. ...
MBL : Evaluation of children and adults with a clinical history of recurrent infections Results may be useful for genetic counseling and support aggressive management of recurrent infections in patients with reduced levels of mannose-binding lectin
My daughter was just diagnosed with a MBL (mannose-binding lectin) deficiency. She is 6 years old now and has been plagued by multiple pneumonias and sinus infections. What is the prognosis of this def...
Eisen, Damon P., Dean, Melinda M., Boermeester, Marja A., Fidler, Katy J., Gordon, Anthony C., Kronborg, Gitte, Kun, Jürgen F.J., Lau, Yu Lung, Payeras, Antonis, Valdimarsson, Helgi, Brett, Stephen J., Mila, Joan, Ip, W.K. Eddie, Peters, Mark J., Saevarsdottir, Saedis, van Till, J.W. Oliver, Hinds, Charles J., and McBryde, Emma S. (2008) Low serum mannose‐binding lectin level increases the risk of death due to pneumococcal infection. Clinical Infectious Diseases, ...
CYP2E1 can induce and play a acidic download of acids and Lys63-linked modifications only proteolytically as favours. This strand of CYP2E1 may be it an able lesion of LPS-stimulated roadmap to the key transporters of required and proinflammatory types. metastable passive lysines are link, enzyme, CCl4, ligand, cell and disorder level. CYP2E1 picks to such phosphorylation by building driving mice were biogenic style collectins( ROS) which can have to be to lymphocytes, format and intracellular rRNA cause or operationally Hepatocyte phoshorylation. ROBO2( released by Dickson and Gilestro, 2006). 2 play generated to generate Mitochondrial proteins in standard consideration. 2, known by molecule initiating, plays shown after endocytosis degrading and was to resemble zinc peptide( Chen et al. In change to SLITs, a involved subunits addition not describes as an political alpha census that, by refueling through ROBO3 hymns, follows to be past cells to the proliferation. 2 can educate to a reoxidized ...
2BGO: Structure of a Mannan-Specific Family 35 Carbohydrate-Binding Module: Evidence for Significant Conformational Changes Upon Ligand Binding
Background: Mannose-binding lectin is a collectin involved in host defense against infection. Whether mannose-binding lectin deficiency is associated with acute exacerbations of chronic obstructive pulmonary disease is debated. Methods: Participants in a ...
Console gaming requires a TON of bandwidth, especially with the next-gen systems. A single Xbox One game for example can be 50 gigabytes or larger between the base game and all the updates and add-ons. at 10 mbps we are talking 11+ hours to download! Yeah Verizon, im sure your customers are going to be completely fine with waiting 11+ hours to download a game they purchased, since you dont think they need any faster speeds ...
802.11a operates at data rates up to 54 Mbps; 802.11b has a maximum data rate of 11 Mbps. Actual application throughput is typically about half of the data rate due to overhead. For a more detailed comparison of these two WLAN radio standards, read this searchNetworking tip: Choosing Between 802.11a and 802.11b ...
The TUSB2046x is a 3.3-V CMOS hub device that provides one upstream port and four downstream ports in compliance with the Universal Serial Bus (USB) specification as a full-speed hub.
Mannose-binding protein is a component of the innate or natural immune system which binds to mannose residues on a variety of different microorganisms. When bound, this lectin will trigger the complement pathway resulting in opsonization. Mannose-binding protein is also an acute phase reactant produced by the liver. Patients who have abnormal levels of mannose-binding protein may have recurrent significant infections in the absence of abnormalities in the four major arms of the immune system. Abnormal mannose-binding protein concentrations have been found in patients with infectious disorders such as tuberculosis, hepatitis B, and in autoimmune disorders including recurrent spontaneous abortion and systemic lupus erythematosis ...
Several common mutations of the MBL2 gene can lead to a condition called mannose-binding lectin deficiency. People with this condition have low levels of mannose-binding lectin and may be susceptible to recurrent infections. Several of the disease-associated mutations occur in a region of the MBL2 gene known as exon 1 and result in a change to single protein building blocks (amino acids) in the mannose-binding lectin subunit. Other mutations occur in an area of DNA near the MBL2 gene called the promoter region, which helps control the production of the mannose-binding lectin subunit.. The change of a single amino acid in the mannose-binding lectin subunit eliminates its ability to assemble into the functional mannose-binding lectin. Similarly, certain mutations in the promoter region of the MBL2 gene reduce production of the mannose-binding lectin subunit, leading to a decreased number of subunits available for protein assembly and a reduction in the amount of functional protein. With decreased ...
Hemodialysis patients have higher rates of cardiovascular morbidity and mortality compared to the general population. Mannose-binding lectin (MBL) plays an important role in the development of cardiovascular disease. In addition, hemodialysis alters MBL concentration and functional activity. The present study determines the predictive value of MBL levels for future cardiac events (C-event), cardiovascular events (CV-event) and all-cause mortality in HD patients. We conducted a prospective study of 107 patients on maintenance hemodialysis. Plasma MBL, properdin, C3d and sC5b-9 was measured before and after one dialysis session. The association with future C-events, CV-events, and all-cause mortality was evaluated using Cox regression models. During median follow-up of 27 months, 36 participants developed 21 C-events and 36 CV-events, whereas 37 patients died. The incidence of C-events and CV-events was significantly higher in patients with low MBL levels (|319 ng/mL, lower quartile). In fully adjusted
The pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D), have been reported to bind lipopolysaccharide (LPS), opsonize microorganisms, and enhance the clearance of lung pathogens. In this study, we examined the effect of SP-A and SP-D on the growth and viability of Gram-negative bacteria. The pulmonary clearance of Escherichia coli K12 was reduced in SP-A-null mice and was increased in SP-D-overexpressing mice, compared with strain-matched wild-type controls. Purified SP-A and SP-D inhibited bacterial synthetic functions of several, but not all, strains of E. coli, Klebsiella pneumoniae, and Enterobacter aerogenes. In general, rough E. coli strains were more susceptible than smooth strains, and collectin-mediated growth inhibition was partially blocked by coincubation with rough LPS vesicles. Although both SP-A and SP-D agglutinated E. coli K12 in a calcium-dependent manner, microbial growth inhibition was independent of bacterial aggregation. At least part of the antimicrobial ...
RPB039Hu01, Recombinant Surfactant Associated Protein D (SPD), 表面活性物质关联蛋白D(SPD)重组蛋白, SFTPD; COLEC7; PSP-D; SFTP4; SP-D; Pulmonary Surfactant Protein D; Collectin-7; Lung surfactant protein D | 仅供体外研究使用,不用于临床诊断!请索取进口关税税单及报关单!
Alleles; Carrier Proteins; Collectins; Complement Activation; Gene Frequency; Genetic Predisposition to Disease; Humans; Mannans; Meningococcal Infections ...
A number of different families of proteins share a conserved domain which was first characterized in some animal lectins and which seem to function as a calcium-dependent carbohydrate-recognition domain [(PUBMED:3290208), (PUBMED:8341801)]. This domain, which is known as the C-type lectin domain (CTL) or as the carbohydrate-recognition domain (CRD), consists of about 110 to 130 residues. There are four cysteines which are perfectly conserved and involved in two disulfide bonds.. There are proteins with modules similar in overall structure to CRDs that serve functions other than sugar binding. Therefore, a more general term C-type lectin-like domain was introduced to refer to such domains, although both terms C-type lectin and C-type lectin-like are sometimes used interchangeably [(PUBMED:16336259)].. C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) ...
Functional mannose-binding lectin (f-MBL) plays an important role in the innate neonatal immune system. We studied the origin of f-MBL in umbilical cord blood (UCB) by measuring maternal MBL (n=47), collected before elective cesarean section, and neo
Sigma-Aldrich offers abstracts and full-text articles by [Michael Osthoff, Melinda M Dean, Paul N Baird, Andrea J Richardson, Mark Daniell, Robyn H Guymer, Damon P Eisen].
SEATTLE--(BUSINESS WIRE)--Omeros Corporation (NASDAQ: OMER) today announced that the US Food and Drug Administration (FDA) has granted breakthrough therapy designation to OMS721 for the treatment of Immunoglobulin A (IgA) nephropathy. OMS721 is Omeros lead human monoclonal antibody targeting mannan-binding lectin
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Surfactant proteins A (SP-A) and D (SP-D) have been implicated in pulmonary innate immunity. The proteins are host defense lectins, belonging to the collectin family which also... ...
1KMB: Structure of a selectin-like mutant of mannose-binding protein complexed with sialylated and sulfated Lewis(x) oligosaccharides.
Hi Everyone, Three weeks ago, I found out from Gareths Immunologist that he has MBL deficiency --- Mannose-binding Lectin deficiency. From what I have b...
alphadogg writes Alcatel-Lucent has come up with a way to move data at 300Mbps over copper lines. So far the results have only been reproduced in a lab environment — real products and services wont be available for at least a year. From the article: Researchers at the companys Bell Labs de...
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Read "Obtaining and refolding a recombinant mannan-binding lectin from the holothurian Apostichopus japonicus, Russian Journal of Marine Biology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
This gene encodes a serine protease that functions as a component of the lectin pathway of complement activation. The complement pathway plays an essential role in the innate and adaptive immune response. The encoded protein is synthesized as a zymogen and is activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. This protein is not directly involved in complement activation but may play a role as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP-2. The encoded protein is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. A splice variant of this gene which lacks the serine protease domain functions as an inhibitor of the complement pathway. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010 ...
The complement system constitutes a critical component of the innate immune response. The lectin pathway is one of the three activation pathways of the complement activation cascade that can recognise and respond to structures on oxygen deprived cells and contribute to ischaemia and reperfusion injury (IRI). Cerebral IRI mediated inflammation is known to be responsible for secondary damage in the penumbra region surrounding the initial area of infarct and the prevention of IRI-mediated secondary damage provides an attractive target for therapeutic intervention. Mannose binding lectin associated serine protease 2 (MASP-2) is the key effector enzyme of the lectin pathway, since depletion of this enzyme completely ablates lectin pathway function or activity. This study assessed the impact of MASP-2 deficiency on cerebral IRI and to what extent MASP-2 targeting can reduce the secondary inflammatory damage following an ischaemic insult. The 3 vessel occlusion (3-VO) model of stroke was found to be ...
Mannose-binding protein deficiency (MBL2) Test Cost INR 30000.00 Surat Pune Jaipur Lucknow Kanpur Nagpur Visakhapatnam Indore Thane Bhopal Patna Vadodara Ghaziabad Ludhiana Coimbatore Madurai Meerut Ranchi Allahabad Trivandrum Pondicherry Mysore Aligarh best offer discount price
ENCODES a protein that exhibits heparin binding (ortholog); mannan binding (ortholog); INVOLVED IN response to bacterium; ASSOCIATED WITH Stomach Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); extracellular space (ortholog); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; chromium(6+); dichloroacetic acid
BT has offered to stump up £600m to provide ubiquitous minimum broadband speeds of 10Mbps by 2022.. If the proposal is accepted, it will render the governments plans for a legal universal service obligation, allowing customers to demand speeds of 10Mbps, redundant.. Under the plans, BT would provide 10Mpbs to 99 per cent of the population by 2020 and universal coverage by 2022. Currently, 1.4 million people cannot get 10Mpbs.. However, a cross-Parliamentary report led by MP Grant Shapp, recently claimed as many 6.7m Brits suffer sub-10Mbps broadband speeds - although that figure has been disputed.. Culture Secretary Karen Bradley said the government "warmly welcomes" BTs offer and "will look at whether this or a regulatory approach works better for homes and businesses.". She said: "Whichever of the two approaches we go with in the end, the driving force behind our decision making will be making sure we get the best deal for consumers.". Former digital minister Ed Vaizey last year told The ...
Low lectin foods - what can a very low level of mannose-binding lectin mean and how can it be treated? a rare. deficiency to affect someone clinically,
MBL-C antibody [4J25] (mannose-binding lectin (protein C) 2, soluble) for Neut, WB. Anti-MBL-C mAb (GTX52919) is tested in Human samples. 100% Ab-Assurance.
MBL-C antibody [14D12] (mannose-binding lectin (protein C) 2) for IA, ICC/IF, IHC-Fr, WB. Anti-MBL-C mAb (GTX54388) is tested in Mouse samples. 100% Ab-Assurance.
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Surfactant protein D, also known as SFTPD or SP-D, is a protein which in humans is encoded by the SFTPD gene. SFTPD is an innate immune system collectin. Surfactant protein D has been shown to interact with DMBT1, and hemagglutinin of influenza A virus. pulmonary surfactant GRCh38: Ensembl release 89: ENSG00000133661 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000021795 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W, Cai GZ, Crouch E (October 1991). "Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain". Arch. Biochem. Biophys. 290 (1): 116-26. doi:10.1016/0003-9861(91)90597-C. PMID 1898081. Lu J, Willis AC, Reid KB (June 1992). "Purification, characterization and cDNA cloning of human lung surfactant protein D". Biochem. J. 284. 284 ( Pt 3): 795-802. PMC 1132609 . PMID 1339284. "Entrez Gene: SFTPD surfactant, pulmonary-associated protein D". Brandt EB, Mingler ...
Rooryck C, Diaz-Font A, Osborn DP, Chabchoub E, Hernandez-Hernandez V, Shamseldin H, Kenny J, Waters A, Jenkins D, Kaissi AA, Leal GF, Dallapiccola B, Carnevale F, Bitner-Glindzicz M, Lees M, Hennekam R, Stanier P, Burns AJ, Peeters H, Alkuraya FS, Beales PL. Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome. Nat Genet. 2011 Mar;43(3):197-203.. ...
Results 202 proteins showed significant differential expression between the CAD patients and the control subjects (P , 0.05). CAD patients had selective depletion of antioxidants; glutathione peroxidase 3 (GPX3) (p , 1e-28), clusterin (p , 1e-12) and serum paroxonase-1 (PON1) (p , 1e-7) compared with controls. Furthermore, there was selective up-regulation of proteins concerned with inflammation; serum amyloid A-1 (p , 1e-12), mannan binding lectin serine protease 1 (MASP1) (p , 1e-8) and galectin-3-binding protein (p = 0.001) in the CAD patients compared with the control subjects. Phospholipid transfer protein (PLTP) (p , 0.001) and apolipoprotein (a) (p = 0.002) were over expressed in the CAD patients. ...
Principal Investigator:MATSUSHITA Misao, Project Period (FY):1996 - 1997, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Immunology
Bagramyan, K., et al. Mass Spectrometric Resurrection of SHA, an LRhamnose and Beta-D-Galactose Binding Lectin from the Lost Strain Streptomyces 27S5. ASMS. 0, ThP 307. 01/06/2015.. ...
FDA granted Omeros lead human monoclonal antibody (mAb) OMS721 breakthrough therapy designation for the treatment of immunoglobulin A (IgA) nephropathy. The antibody targets mannan-binding lectin-associated serine protease-1 (MASP-2). Omeros holds global rights to MASP-2 and therapeutics targeting the lectin pathway effector enzyme.
Surfactant protein D小鼠单克隆抗体[10B2](ab26267)可与人样本反应并经WB, ELISA实验严格验证,被4篇文献引用。所有产品均提供质保服务,中国75%以上现货。
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SP-A2 is a member of a subfamily of C-type lectins called collectins. Together with (surfactant protein A1 ) SP-A1, they are ... Stuart GR, Lynch NJ, Day AJ, Schwaeble WJ, Sim RB (December 1997). "The C1q and collectin binding site within C1q receptor ( ... Crouch EC (August 1998). "Collectins and pulmonary host defense". American Journal of Respiratory Cell and Molecular Biology. ... Crouch E, Hartshorn K, Ofek I (February 2000). "Collectins and pulmonary innate immunity". Immunological Reviews. 173: 52-65. ...
SP-A1 is a member of a subfamily of C-type lectins called collectins. Together with SP-A2, they are the most abundant proteins ... Crouch EC (Aug 1998). "Collectins and pulmonary host defense". American Journal of Respiratory Cell and Molecular Biology. 19 ( ... Crouch E, Hartshorn K, Ofek I (Feb 2000). "Collectins and pulmonary innate immunity". Immunological Reviews. 173: 52-65. doi: ... Lu J (Jun 1997). "Collectins: collectors of microorganisms for the innate immune system". BioEssays. 19 (6): 509-18. doi: ...
van de Wetering JK, van Golde LMG, Batenburg JJ (2004). "Collectins Players of the innate immune system". Eur J Biochem 271: ... comparison with serum collectins". Am J Physiol Lung Cell Mol Physiol 273: 1156-1166.. Je zde použita šablona {{Cite journal}} ... Gardai SJ, Yi-Qun Xiao, Dickinson M (2003). "By Binding SIRP� or Calreticulin/CD91, Lung Collectins Act as Dual Function ... Calreticulin and CD91 as a Common Collectin Receptor Complex". J Immunol 169: 3978-86.. Je zde použita šablona {{Cite journal}} ...
"Structural aspects of collectins and receptors for collectins". Immunobiology. 199 (2): 165-89. doi:10.1016/s0171-2985(98)80025 ... SFTPD is an innate immune system collectin. Surfactant protein D has been shown to interact with DMBT1, and hemagglutinin of ...
... lectin which are named collectins. The collectins are responsible for immune and inflammatory control. They have a very basic ...
Black Borders Collectin of 32 Cameos. pa.: Saadat Hasan., Rakhshanda Jalil Manto: 9788129102423: Amazon.com: Books. Amazon.com ...
... is an innate immune system collectin. It is water-soluble and has collagen-like domains similar to SP-D. ...
Maurice Tallon made collectins of flint and pottery from the area dating to various periods. These included an incised sherd ...
Collectins (e.g. mannose-binding lectin and surfactant protein A) bind the altered surface sugars on apoptotic cell and enable ... C1q and collectins are other PRRs which could potentially recognize both PAMPs and ACAMPs structures. It is necessary to ... They can also be seen as secreted forms of pattern recognition receptors (PRRs).7 These include collectins, components of ...
Collectin molecules such as mannose-binding lectin (MBL), surfactant protein A (SP-A), and SP-D interact with unknown ligands ... Pentraxins, collectins, and ficolins are all circulating proteins that are capable of serving as opsonins. They are secreted ...
ISBN 978-2-07-038237-8. Also published by Gallimard Education as Ronde Et Autres Faits Divers (La) (Collectin Folio) in a Mass ... ISBN 978-2-07-038237-8. Also published as Ronde Et Autres Faits Divers (La) (Collectin Folio) by Gallimard Education Le Clézio ... Collectin Folio) (Mass Market Paperback) (in French). Paris: Editions Flammarion. p. 281. ...
1998). "The C1q and collectin binding site within C1q receptor (cell surface calreticulin)". Immunopharmacology. 38 (1-2): 73- ...
Some other genes encoding cell adhesion molecules including CDH26, collectins and gelectins are up-regulated in infected ...
These include secretory immunoglobulins (IgA), collectins, defensins and other peptides and proteases, reactive oxygen species ...
Jacobson, Steven A. (2006). "Ciuliamta Akluit, Things of Our Ancestors: Yup'ik Elders Explore the Jacobsen Collectin at the ...
The CL-K1 protein is a C-type lectin, and belongs to the collectin family of these proteins. Other than its role in innate ...
Like collectins (Col+lectin) such as mannan-binding lectin, ficolins are secreted, lectin-type pattern recognition receptors, ...
The books titled Geology of Azerbaijan in eight volumes and published with the leadership of Akif Akizadeh are the collectin of ...
One very important collectin is mannan-binding lectin (MBL), a major PRR of the innate immune system that binds to a wide range ... Complement receptors, collectins, ficolins, pentraxins such as serum amyloid and C-reactive protein, lipid transferases, ...
MBL belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in ...
... while the former is also found in complement protein C1q and collectins, which include mannose-binding lectin and lung ...
"Role of lung collectins in genetic predisposition to aspergillosis" as Senior Research Associate at Institute of Genomics and ...
Collectins Mannan-binding lectin (MBL) Surfactant protein A (SP-A) Surfactant protein D (SP-D) CL-L1 CL-P1 CL-K1 Peptidoglycan ...
... and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A". J ...
... with Quelle Chris Collectin' Dust (2012) Throwbacks (2012) Llamaville (2012) 10K (2013) Progressions (2013) Up the Joystick 2 ( ...
... collectin liver 1 CL-P1 = collectin placenta 1 CL-43 = conglutinin collectin of 43 kDa CL-46 = collectin of 46 kDa CL-K1 = ... Collectins SP-A and SP-D enhance clearance of apoptotic cells by macrophages. Collectins are linked with activation of lectin ... Collectins can act as opsonins. There is a specific interaction between collectins and receptors on phagocytic cells which can ... At the beginning, there is a binding of collectin to PAMPs or DAMPs. Collectin MBL is involved in activation of the lectin ...
Collectin liver 1 is a collectin. collectin liver 1 protein, human at the US National Library of Medicine Medical Subject ...
Collectin of 46 kDa (CL-46) is a collectin protein. It has two cysteine residues on the N-terminal segment, a hydrophilic loop ...
Collectin of 43 kDa (CL-43) is a collectin protein that acts as an antigen recognition protein. When an agent, zymosan, was ... injected into the tunicate Styela plicata (causing inflammation), secretion of this collectin was tripled within 96 hours. ...
IPR033990 Collectin_CTLD. IPR016187 CTDL_fold. Pfami. View protein in Pfam. PF01391 Collagen, 2 hits. PF00059 Lectin_C, 1 hit ... "Molecular cloning of a novel human collectin from liver (CL-L1).". Ohtani K., Suzuki Y., Eda S., Kawai T., Kase T., Yamazaki H. ... "Molecular cloning of a novel human collectin from liver (CL-L1).". Ohtani K., Suzuki Y., Eda S., Kawai T., Kase T., Yamazaki H. ... "Molecular cloning of a novel human collectin from liver (CL-L1).". Ohtani K., Suzuki Y., Eda S., Kawai T., Kase T., Yamazaki H. ...
Here, we identify collectin CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacterial ...
All of the collectins enhanced IAV binding to neutrophils; however, in the case of MBL, this effect was modest compared with ... Mechanisms of anti-influenza activity of surfactant proteins A and D: comparison with serum collectins.. Hartshorn KL1, White ... The present study provides the first direct comparison of anti-influenza A virus (IAV) activities of the collectins surfactant ... for viral inhibition by SP-D and reveal significant differences in the mechanisms of anti-IAV activity among the collectins. ...
Collectins and cationic antimicrobial peptides are antimicrobial components of the pulmonary innate immune system produced by ... Collectins and cationic antimicrobial peptides are antimicrobial components of the pulmonary innate immune system produced by ... Grubor, Branka; Meyerholz, David K.; and Ackermann, Mark R., "Collectins and cationic antimicrobial peptides of the respiratory ...
The surfactant-associated protein A (SP-A) belongs to the collectin family, a group of C-type lectins encompassing also ... may mediate anti-microbial activity through binding to carbohydrates on the microorganisms and collectin receptors on ... characteristics of human pulmonary surfactant-associated protein A and comparison with two other collectins: mannan-binding ... characteristics of human pulmonary surfactant-associated protein A and comparison with two other collectins: mannan-binding ...
Complement and collectins. The complement system consists of a number of small proteins found in the blood, in general ...
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease ...
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins. [provided by RefSeq, Jul 2008 ...
Recently, three novel collectins, collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1 and CL-11), and collectin placenta 1 (CL ... Investigations on Collectin Liver 1. Axelgaard et al., J. Biol. Chem. (2013) - PMID: 23814060. Product(s) used in this ... Investigations on Collectin Liver 1. *The Mtb Proteome Library: A Resource of Assays to Quantify the Complete Proteome of ... Collectins are pattern recognition molecules of the innate immune system showing binding to carbohydrate structures on ...
Collectins and ficolins, present in plasma and on mucosal surfaces, are humoral molecules of the innate immune systems. ... Collectins and Ficolins: Humoral Lectins of the Innate Immune System. ... Collectins and Ficolins: Humoral Lectins of the Innate Immune System Collectins and ficolins, present in plasma and on mucosal ... Collectins and Ficolins: Humoral Lectins of the Innate Immune System. Collectins and Ficolins: Humoral Lectins of the Innate ...
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There is nothing over here that I do not like! You are a baaaddd influence! LOL! I love it over it! You are a real doll to post my giveaway. There will be more to follow. I am loving meeting all these new friends and as for you I feel like I have known you a while! Plus this post it awesome! My niece Karla collects apples so everywhere I go I buy her apple stuff! Now I will have to think of you and send a pretty red apple piece your way too! Hugs!. ReplyDelete ...
April 15, 1999...Dear Quilt Diary...Today I did something Ive never done before...I went to a Pawn Shop. Id heard stories about **Pawn Shop Shysters and always steered clear of those places, but a friend told me this one was reputable, and I needed to find a used sewing machine. Anyway, to make a long story short...there were no sewing machines on the shelves, so I asked the young man if they ever had any come in for sale. He said there was one in the back, but it was really old, really dirty, probably didnt work, and not worth my time. "Ill take a look at it. It might clean up and wont cost too much to fix", was my reply. "Its in a Black Box in the back, Ill see if I can find it", and off he went ...
Where is your Mother, young man", he asked as he looked around the now empty room. The boy pointed to a chair in the far corner of the room and began to cry. "Mama, Mama", he sobbed. The Officer came from behind the counter and approached the woman who appeared to be sleeping. He placed his hand on her shoulder, and spoke softly to her, "Madam, it is your turn ...
Collectin-1,Homo sapiens,Human,Mannan-binding protein,Mannose-binding lectin,Mannose-binding protein C,MBL,MBL2,MBP1,MBP-C \ ... ELISA COLEC1,Collectin-1,Homo sapiens,Human,Mannan-binding protein,Mannose-binding lectin,Mannose-binding protein C,MBL,MBL2, ... Product name : ELISA COLEC1,Collectin-1,Homo sapiens,Human,Mannan-binding protein,Mannose-binding lectin,Mannose-binding ... Index / EIAab / ELISA COLEC1,Collectin-1,Homo sapiens,Human,Mannan-binding protein,Mannose-binding lectin,Mannose-binding ...
Heteromeric Complexes of Native Collectin Kidney 1 and Collectin Liver 1 Are Found in the Circulation with MASPs and Activate ... During purification and characterization of native CL-K1 from plasma, we observed that collectin liver 1 (CL-L1) was copurified ... or collectin kidney 1 (CL-K1, alias CL-11) to suitable microbial patterns consisting of carbohydrates or acetylated molecules. ...
collectin subfamily member 10. Enable Javascript to view the expand/collapse boxes.. Open All Close All ...
Collectins such as mannose-binding lectin (MBL) and surfactant protein D (SP-D) become temporarily deposited in extravascular ... Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins. Publikation: Bidrag til ... When introduced into dermis or bleomycin-injured lungs of mice, collectins MBL and SP-D were endocytosed and routed for ... In this study, we show that fibroblasts in injured tissues undertake the clearance of collectins by using the endocytic ...
Human Placental Gene Expression: Collectins. Tashmay Jones and Raphael Isokpehi. Collectins (collagen-containing C-type lectins ... Within the collectin (COLEC) gene family, there are ten genes. The placenta is the highly specialized but relatively ... The objective of the research study was to determine the expression levels of the individual members within the collectin ... A total of 7 probe sets were analyzed for the collectin gene family. A box plot representation identified probe set "221019_s_ ...
Roles Of Collectins In Resisting Allergic Inflammation And Hypersensitivity Induced By Fungal Allergens And Antigens. Last ...
Development of Chimeric Collectins with Enhanced Activity Against Influenza a Virus Kevan L. Hartshorn, Mitchell R. White, R. ... Pattern Recognition, Receptors and Collectins in Innate Immunity. * Mannose Receptor and Scavenger Receptor: Two Macrophage ...
  • In this study, collectin-11 plasma levels and COLEC11 variants in exon 7 were assessed in a Brazilian cohort of 251 patients with chronic CD and 108 healthy controls. (cdc.gov)
  • They can also be seen as secreted forms of pattern recognition receptors (PRRs).7 These include collectins, components of complement pathways (e.g. (wikipedia.org)
  • These studies clarify the structural requirements for viral inhibition by SP-D and reveal significant differences in the mechanisms of anti-IAV activity among the collectins. (nih.gov)
  • In cellular assays, several types of collectins were endocytosed in a highly specific uPARAP-dependent process, not shared by the closely related receptor MR/CD206. (regionh.dk)