A class of C-type lectins that target the carbohydrate structures found on invading pathogens. Binding of collectins to microorganisms results in their agglutination and enhanced clearance. Collectins form trimers that may assemble into larger oligomers. Each collectin polypeptide chain consists of four regions: a relatively short N-terminal region, a collagen-like region, an alpha-helical coiled-coil region, and carbohydrate-binding region.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens and enhances their opsinization and killing by phagocytic cells. Surfactant protein D contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
An abundant pulmonary surfactant-associated protein that binds to a variety of lung pathogens, resulting in their opsinization. It also stimulates MACROPHAGES to undergo PHAGOCYTOSIS of microorganisms. Surfactant protein A contains a N-terminal collagen-like domain and a C-terminal lectin domain that are characteristic of members of the collectin family of proteins.
All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)
Proteins found in the LUNG that act as PULMONARY SURFACTANTS.
Substances and drugs that lower the SURFACE TENSION of the mucoid layer lining the PULMONARY ALVEOLI.
A specific mannose-binding member of the collectin family of lectins. It binds to carbohydrate groups on invading pathogens and plays a key role in the MANNOSE-BINDING LECTIN COMPLEMENT PATHWAY.
Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
Polysaccharides consisting of mannose units.
Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.
A subcomponent of complement C1, composed of six copies of three polypeptide chains (A, B, and C), each encoded by a separate gene (C1QA; C1QB; C1QC). This complex is arranged in nine subunits (six disulfide-linked dimers of A and B, and three disulfide-linked homodimers of C). C1q has binding sites for antibodies (the heavy chain of IMMUNOGLOBULIN G or IMMUNOGLOBULIN M). The interaction of C1q and immunoglobulin activates the two proenzymes COMPLEMENT C1R and COMPLEMENT C1S, thus initiating the cascade of COMPLEMENT ACTIVATION via the CLASSICAL COMPLEMENT PATHWAY.
Proteins that bind to particles and cells to increase susceptibility to PHAGOCYTOSIS, especially ANTIBODIES bound to EPITOPES that attach to FC RECEPTORS. COMPLEMENT C3B may also participate.
The aggregation of ERYTHROCYTES by AGGLUTININS, including antibodies, lectins, and viral proteins (HEMAGGLUTINATION, VIRAL).
Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.
Serologic tests in which a known quantity of antigen is added to the serum prior to the addition of a red cell suspension. Reaction result is expressed as the smallest amount of antigen which causes complete inhibition of hemagglutination.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Simple sugars, carbohydrates which cannot be decomposed by hydrolysis. They are colorless crystalline substances with a sweet taste and have the same general formula CnH2nOn. (From Dorland, 28th ed)
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
A bacterium causing tuberculosis in domestic fowl and other birds. In pigs, it may cause localized and sometimes disseminated disease. The organism occurs occasionally in sheep and cattle. It should be distinguished from the M. avium complex, which infects primarily humans.
Transport proteins that carry specific substances in the blood or across cell membranes.
The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.
A biosensing technique in which biomolecules capable of binding to specific analytes or ligands are first immobilized on one side of a metallic film. Light is then focused on the opposite side of the film to excite the surface plasmons, that is, the oscillations of free electrons propagating along the film's surface. The refractive index of light reflecting off this surface is measured. When the immobilized biomolecules are bound by their ligands, an alteration in surface plasmons on the opposite side of the film is created which is directly proportional to the change in bound, or adsorbed, mass. Binding is measured by changes in the refractive index. The technique is used to study biomolecular interactions, such as antigen-antibody binding.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
The chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, especially peptides or proteins. Glycosyl transferases are used in this biochemical reaction.
Proteins prepared by recombinant DNA technology.
A class of animal lectins that bind to carbohydrate in a calcium-dependent manner. They share a common carbohydrate-binding domain that is structurally distinct from other classes of lectins.
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
Protein or glycoprotein substances of plant origin that bind to sugar moieties in cell walls or membranes. Some carbohydrate-metabolizing proteins (ENZYMES) from PLANTS also bind to carbohydrates, however they are not considered lectins. Many plant lectins change the physiology of the membrane of BLOOD CELLS to cause agglutination, mitosis, or other biochemical changes. They may play a role in plant defense mechanisms.
A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.
A medical specialty concerned with the diagnosis and treatment of diseases of the internal organ systems of adults.
Those individuals engaged in research.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Ordered compilations of item descriptions and sufficient information to afford access to them.
A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.
A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The class Insecta, in the phylum ARTHROPODA, whose members are characterized by division into three parts: head, thorax, and abdomen. They are the dominant group of animals on earth; several hundred thousand different kinds having been described. Three orders, HEMIPTERA; DIPTERA; and SIPHONAPTERA; are of medical interest in that they cause disease in humans and animals. (From Borror et al., An Introduction to the Study of Insects, 4th ed, p1)
A large family of cell surface receptors that bind conserved molecular structures (PAMPS) present in pathogens. They play important roles in host defense by mediating cellular responses to pathogens.
Plasmids coding for proteins which induce PLANT TUMORS. The most notable example of a plant tumor inducing plasmid is the Ti plasmid found associated with AGROBACTERIUM TUMEFACIENS.
PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.
Diseases of plants.
The inherent or induced capacity of plants to withstand or ward off biological attack by pathogens.

Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene. (1/252)

Mannan-binding lectin (MBL) forms a multimolecular complex with at least two MBL-associated serine proteases, MASP-1 and MASP-2. This complex initiates the MBL pathway of complement activation by binding to carbohydrate structures present on bacteria, yeast, and viruses. MASP-1 and MASP-2 are composed of modular structural motifs similar to those of the C1q-associated serine proteases C1r and C1s. Another protein of 19 kDa with the same N-terminal sequence as the 76-kDa MASP-2 protein is consistently detected as part of the MBL/MASP complex. In this study, we present the primary structure of this novel MBL-associated plasma protein of 19 kDa, MAp19, and demonstrate that MAp19 and MASP-2 are encoded by two different mRNA species generated by alternative splicing/polyadenylation from one structural gene.  (+info)

C1qRP is a heavily O-glycosylated cell surface protein involved in the regulation of phagocytic activity. (2/252)

C1q, mannose-binding lectin (MBL), and pulmonary surfactant protein A (SPA) interact with human monocytes and macrophages, resulting in the enhancement of phagocytosis of suboptimally opsonized targets. mAbs that recognize a cell surface molecule of 126,000 Mr, designated C1qRP, have been shown to inhibit C1q- and MBL-mediated enhancement of phagocytosis. Similar inhibition of the SPA-mediated enhancement of phagocytosis by these mAbs now suggests that C1qRP is a common component of a receptor for these macromolecules. Ligation of human monocytes with immobilized R3, a IgM mAb recognizing C1qRP, also triggers enhanced phagocytic capacity of these cells in the absence of ligand, verifying the direct involvement of this polypeptide in the regulation of phagocytosis. While the cDNA for C1qRP encodes a 631 amino acid membrane protein, Chinese hamster ovary cells transfected with the cDNA of the C1qRP coding region express a surface glycoprotein with the identical 126,000 Mr in SDS-PAGE as the native C1qRP. Use of glycosylation inhibitors, cleavage of the mature C1qRP with specific glycosidases, and in vitro translation of C1qRP cDNA demonstrated that both posttranslational glycosylation and the nature of the amino acid sequence of the protein contribute to the difference between its predicted m.w. and its migration on SDS-PAGE. These results verify that the cDNA cloned codes for the mature C1qRP, that C1qRP contains a relatively high degree of O-linked glycoslyation, and that C1qRP cross-linked directly by monoclonal anti-C1qRP or engaged as a result of cell surface ligation of SPA, as well as C1q and MBL, enhances phagocytosis.  (+info)

KM+, a mannose-binding lectin from Artocarpus integrifolia: amino acid sequence, predicted tertiary structure, carbohydrate recognition, and analysis of the beta-prism fold. (3/252)

The complete amino acid sequence of the lectin KM+ from Artocarpus integrifolia (jackfruit), which contains 149 residues/mol, is reported and compared to those of other members of the Moraceae family, particularly that of jacalin, also from jackfruit, with which it shares 52% sequence identity. KM+ presents an acetyl-blocked N-terminus and is not posttranslationally modified by proteolytic cleavage as is the case for jacalin. Rather, it possesses a short, glycine-rich linker that unites the regions homologous to the alpha- and beta-chains of jacalin. The results of homology modeling implicate the linker sequence in sterically impeding rotation of the side chain of Asp141 within the binding site pocket. As a consequence, the aspartic acid is locked into a conformation adequate only for the recognition of equatorial hydroxyl groups on the C4 epimeric center (alpha-D-mannose, alpha-D-glucose, and their derivatives). In contrast, the internal cleavage of the jacalin chain permits free rotation of the homologous aspartic acid, rendering it capable of accepting hydrogen bonds from both possible hydroxyl configurations on C4. We suggest that, together with direct recognition of epimeric hydroxyls and the steric exclusion of disfavored ligands, conformational restriction of the lectin should be considered to be a new mechanism by which selectivity may be built into carbohydrate binding sites. Jacalin and KM+ adopt the beta-prism fold already observed in two unrelated protein families. Despite presenting little or no sequence similarity, an analysis of the beta-prism reveals a canonical feature repeatedly present in all such structures, which is based on six largely hydrophobic residues within a beta-hairpin containing two classic-type beta-bulges. We suggest the term beta-prism motif to describe this feature.  (+info)

Molecular cloning of a novel human collectin from liver (CL-L1). (4/252)

Collectins are a C-lectin family with collagen-like sequences and carbohydrate recognition domains. These proteins can bind to carbohydrate antigens of microorganisms and inhibit their infection by direct neutralization and agglutination, the activation of complement through the lectin pathway, and opsonization by collectin receptors. Here we report the cloning of a cDNA encoding human collectin from liver (CL-L1 (collectin liver 1)) that has typical collectin structural characteristics, consisting of an N-terminal cysteine-rich domain, a collagen-like domain, a neck domain, and a carbohydrate recognition domain. The cDNA has an insert of 831 base pairs coding for a protein of 277 amino acid residues. The deduced amino acid sequence shows that this collectin has a unique repeat of four lysine residues in its C-terminal area. Northern blot, Western blot, and reverse transcription-polymerase chain reaction analyses showed that CL-L1 is present mainly in liver as a cytosolic protein and at low levels in placenta. More sensitive analyses by reverse transcription-polymerase chain reactions showed that most tissues (except skeletal muscle) have CL-L1 mRNA. Zoo-blot analysis indicated that CL-L1 is limited to mammals and birds. A chromosomal localization study indicated that the CL-L1 gene localizes to chromosome 8q23-q24.1, different from chromosome 10 of other human collectin genes. Expression studies of fusion proteins lacking the collagen and N-terminal domains produced in Escherichia coli affirmed that CL-L1 binds mannose weakly. CL-L1 and recombinant CL-L1 fusion proteins do not bind to mannan columns. Analysis of the phylogenetic tree of CL-L1 and other collectins indicated that CL-L1 belongs to a fourth subfamily of collectins following the mannan-binding protein, surfactant protein A, and surfactant protein D subfamilies including bovine conglutinin and collectin-43 (CL-43). These findings indicate that CL-L1 may be involved in different biological functions.  (+info)

Isolation, characterization, molecular cloning and molecular modelling of two lectins of different specificities from bluebell (Scilla campanulata) bulbs. (5/252)

Two lectins have been isolated from bluebell (Scilla campanulata) bulbs. From their isolation by affinity chromatography, they are characterized as a mannose-binding lectin (SCAman) and a fetuin-binding lectin (SCAfet). SCAman preferentially binds oligosaccharides with alpha(1,3)- and alpha(1,6)-linked mannopyranosides. It is a tetramer of four identical protomers of approx. 13 kDa containing 119 amino acid residues; it is not glycosylated. The fetuin-binding lectin (SCAfet), which is not inhibited by any simple sugars, is also unglycosylated. It is a tetramer of four identical subunits of approx. 28 kDa containing 244 residues. Each 28 kDa subunit is composed of two 14 kDa domains. Both lectins have been cloned from a cDNA library and sequenced. X-ray crystallographic analysis and molecular modelling studies have demonstrated close relationships in sequence and structure between these lectins and other monocot mannose-binding lectins. A refined model of the molecular evolution of the monocot mannose-binding lectins is proposed.  (+info)

Glomerular deposition of mannose-binding lectin in human glomerulonephritis. (6/252)

BACKGROUND: Mannose-binding lectin (MBL), a member of the collectin family, binds to various oligosaccharides and activates the classical pathway of complement independent from C1q. At present it is unknown whether this so-called lectin pathway of complement activation plays a role in the pathogenesis of human glomerulonephritis. METHODS: Direct immunofluorescence of 84 renal biopsies using an MBL-specific monoclonal antibody and antibodies directed against IgG, IgA, IgM, C1q, C3, and terminal complement complex (TCC) was performed. Serum MBL levels of 50 patients were determined by enzyme-linked immunosorbent assay. RESULTS: MBL was detected in the glomeruli of patients with lupus nephropathy (15 of 16), membranous nephropathy (10/15), membranoproliferative glomerulonephritis type I (5/6) and anti-GBM nephritis (2/4). MBL deposition paralleled that of immunoglobulins, C1q, C3, and TCC but was less intense as compared to C1q. Focal segmental deposits of MBL were present in focal segmental glomerulosclerosis (4/6), IgA nephropathy (3/11), amyloidosis AL (1/4), and advanced renal fibrosis (2/2). Here MBL staining was identical to IgM and C3 and considered an unspecific entrapment of MBL in sclerotic lesions in these cases. No significant difference in MBL serum levels was observed between normal controls and patients with lupus nephritis, membranous nephropathy, membranoproliferative glomerulonephritis, focal segmental sclerosis, minimal change disease or IgA nephropathy. In patients suffering from membranous nephropathy with (n=10) or without (n=5) glomerular MBL deposits serum creatinine, C3, C4, serum protein, and proteinuria were not statistically different. CONCLUSION: MBL is present in the glomeruli of patients with glomerulonephritis involving deposition of IgG and activation of the classical pathway of complement. We propose that MBL binds to agalactosyl oligosaccharides of IgG that terminate in N-acetylglucosamine. The extent to which the lectin pathway of complement contributes to overall complement activation in the glomeruli remains unknown, but is likely to be marginal.  (+info)

The significance of IgG subclasses and mannan-binding lectin (MBL) for susceptibility to infection in apparently healthy adults with IgA deficiency. (7/252)

The aim of this study was to investigate the significance of IgG subclasses and MBL for susceptibility to infection in association with IgA deficiency. The study population consisted of 139 apparently healthy adult blood donors with IgA deficiency and normal serum levels of IgG and IgM, and an increased susceptibility to infection demonstrated at a population level. Additionally, 216 controls matched for age and sex were investigated. IgG4 deficiency was more common and the mean level of IgG4 lower in persons with IgA deficiency than in the controls. No significant associations could be demonstrated between overt IgG subclass deficiencies and increased susceptibility to infection. However, when the mean concentrations of IgG subclasses were analysed with regard to medical history, that of IgG1 was lower in persons who reported recurrent viral respiratory infections, that of IgG3 in persons who had episodes of severe infection in their history, and that of IgG4 in persons who had recurrent mild respiratory infections, compared with those who had no particular history of infections. In contrast, MBL deficiency-alone or combined with that of the IgG subclass-was not associated with increased susceptibility to infection in persons with IgA deficiency. The results indicate that the proneness to infections observed in a population of otherwise healthy persons with IgA deficiency can only for a small part be accounted for by concomitant deficiencies of IgG subclasses. Contrary to expectations, no synergism between the deficiencies of IgA and MBL could be demonstrated.  (+info)

Antibody-independent classical complement pathway activation and homologous C3 deposition in xeroderma pigmentosum cell lines. (8/252)

Of human malignantly transformed cell lines, xeroderma pigmentosum (XP) cell lines were found to be highly susceptible to homologous complement (C): cells were opsonized by C3 fragments on incubation with diluted normal human serum. C3 fragment deposition on XP cells was Ca2+-dependent and occurred on live cells but not UV-irradiated apoptotic cells. (Ca2+ is required for activation of the classical C pathway via C1q and the lactin pathway via mannose binding lectin (MBL), and the surface of apoptotic cells usually activates the alternative C pathway.) In this study we tested which of the pathways participates in XP cell C3 deposition. In seven cell lines that allowed C3 deposition (i), Clq was shown to be essential but MBL played no role in C activation, (ii) Cls but not MASP bound XP cells for activation, (iii) no antibodies recognizing XP cells were required for homologous C3 deposition, and (iv) the alternative pathway barely participated in C3 deposition. Furthermore, the levels of C-regulatory proteins for host cell protection against C, decay-accelerating factor (DAF, CD55) and membrane cofactor protein (MCP, CD46), were found to be relatively low in almost all XP cell lines compared with normal cells. These results indicate that XP cells activate the classical C pathway in an antibody-independent manner through the expression of a molecule which directly attracts C1q in a C-activating form, and that relatively low levels of DAF and MCP on XP cells facilitate effective C3 deposition. The possible relationship between the pathogenesis of XP and our findings is discussed.  (+info)

Download Free Full-Text of an article Serum mannan-binding lectin in patients with pulmonary tuberculosis: Its lack of a relationship to the disease and response to treatment
Collectins such as mannose-binding lectin (MBL) and surfactant protein D (SP-D) become temporarily deposited in extravascular compartments after tissue injury and perform immune-stimulatory or inflammation-limiting functions. However, their turnover mechanisms, necessary to prevent excessive tissue damage, are virtually unknown. In this study, we show that fibroblasts in injured tissues undertake the clearance of collectins by using the endocytic collagen receptor uPARAP. In cellular assays, several types of collectins were endocytosed in a highly specific uPARAP-dependent process, not shared by the closely related receptor MR/CD206. When introduced into dermis or bleomycin-injured lungs of mice, collectins MBL and SP-D were endocytosed and routed for lysosomal degradation by uPARAP-positive fibroblasts. Fibroblast-specific expression of uPARAP governed endogenous SP-D levels and overall survival after lung injury. In lung tissue from idiopathic pulmonary fibrosis patients, a strong ...
Collectins are oligomeric proteins composed of C type lectin domains connected to collagen regions (1). Three collectins are known in humans: mannan-binding lectin (MBL), a serum protein, and the lung surfactant proteins A and D (SP-A and SP-D), which are produced by epithelial cells mainly in the lung. The collectins play an important role in innate immunity by binding to specific carbohydrate structures found on the surfaces of pathogenic microorganisms, including bacteria, viruses, yeasts, and parasitic protozoa. The binding promotes effector mechanisms such as aggregation, hindrance of infection, activation of phagocytes, and initiation of phagocytosis. After binding to microbial surfaces, MBL activates the complement system through a complement activation pathway, the MBL pathway, by using two recently identified serine proteases, MASP-1 and MASP-2, to activate C4 and C2 (2).. SP-D is mainly produced by alveolar type II cells but is also present in sweat, salivary, tear, and mammary glands ...
Jens Chr. Jensenius, Steen B. Laursen, Yupei Zheng, Uffe Holmskov; Conglutinin and CL-43, two collagenous C-type lectins (collectins) in bovine serum. Biochem Soc Trans 1 February 1994; 22 (1): 95-100. doi: https://doi.org/10.1042/bst0220095. Download citation file:. ...
(= MBL; formerly mannan binding protein, MBP) Plasma protein (32 kD) structurally related to complement C1, that binds specific carbohydrates (mannans) on the surface of various microorganisms including bacteria, yeasts, parasitic protozoa, and…
Rynkiewicz MJ, Wu H, Cafarella TR, Nikolaidis NM, Head JF, Seaton BA, McCormack FX. (2017) Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop. Biochemistry. Aug 8; 56(31):4095-4105. PMID: 28719181.. Rynkiewicz MJ, Fischer S, Lehman W. (2016) The propensity for tropomyosin twisting in the presence and absence of F-actin. Arch Biochem Biophys. 2016 Nov 1; 609:51-58. PMID: 27663225.. Goh BC, Wu H, Rynkiewicz MJ, Schulten K, Seaton BA, McCormack FX. (2016) Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations. Biochemistry. 2016 Jul 5; 55(26):3692-701. PMID: 27324153.. Fischer S, Rynkiewicz MJ, Moore JR, Lehman W. (2016) Tropomyosin diffusion over actin subunits facilitates thin filament assembly. Struct Dyn. 2016 Jan 14; 3(1):012002. PMID: 26798831.. Rynkiewicz MJ, Schott V, Orzechowski M, Lehman W, Fischer S. (2015) Electrostatic ...
Principal Investigator:KAWASAKI Nobuko, Project Period (FY):1993 - 1994, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Biological pharmacy
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TY - JOUR. T1 - Reaction of Bovine Conglutinin in Human in Vitro Phagocytic Systems. AU - Kronvall, Göran. AU - Dossett, John. AU - Quie, Paul G.. AU - Williams, Ralph C.. PY - 1970/1/1. Y1 - 1970/1/1. N2 - Bovine conglutinin, a naturally occurring anti-C3 factor, was studied in quantitative human in vitro phagocytosis systems. Striking antiopsonic effect was noted when conglutinin was added to phagocytic systems with gram-negative and gram-positive organisms dependent on heat-labile opsonic factors. In noncomplement-dependent test systems using isolated hyperimmune γG opsonins, no blocking by conglutinin was noted.. AB - Bovine conglutinin, a naturally occurring anti-C3 factor, was studied in quantitative human in vitro phagocytosis systems. Striking antiopsonic effect was noted when conglutinin was added to phagocytic systems with gram-negative and gram-positive organisms dependent on heat-labile opsonic factors. In noncomplement-dependent test systems using isolated hyperimmune γG ...
To investigate the point mutation at codon 54 of mannose binding lectin (MBL) gene, detect the plasma MBL level, and analyze the correlation between the gene mutation frequency and plasma MBL concentration. A method for detecting MBL gene point mutation (PCR-RFLP) was established with self-designed primers according to MBL genomic sequence. The plasma MBL concentration was detected by MBL Oliger ELISA kit. The PCR-RFLP for detecting the point mutation at codon 54 of MBL gene was established. Frequency of point mutation at codon 54 of MBL gene in healthy Mongolians was 0.18. The plasma MBL concentration was (2.53+/-1.96)mg/L. There was negative correlation between plasma MBL concentration and MBL gene mutation frequency in Mongolians (r = -0.641). The established method of PCR-RFLP was proved to have high specificity, excellent reproducibility and high sensitivity. The relationship between frequency of mutation at codon 54 of MBL gene and the plasma MBL concentration in healthy Mongolians is ...
RATIONALE: Recombinant human mannose-binding lectin (MBL) may be effective in preventing infection in young patients with fever and neutropenia receivin
Structural variants of the Mannose Binding Lectin (MBL) cause quantitative and qualitative functional deficiencies, which are associated with various patterns of susceptibility to infectious diseases and other disorders. We determined genetic MBL variants in 2010 Ghanaian patients with pulmonary tuberculosis (TB) and 2346 controls and characterized the mycobacterial isolates of the patients. Assuming a recessive mode of inheritance, we found a protective association between TB and the MBL2 G57E variant (odds ratio 0.60, confidence interval 0.4-0.9, P 0.008) and the corresponding LYQC haplotype (Pcorrected 0.007) which applied, however, only to TB caused by M. africanum but not to TB caused by M. tuberculosis. In vitro, M.africanum isolates bound recombinant human MBL more efficiently than did isolates of M. tuberculosis. We conclude that MBL binding may facilitate the uptake of M. africanum by macrophages, thereby promoting infection and that selection by TB may have favoured the spread of ...
This unit contains protocols that can be used to measure mannan‐binding lectin (MBL) levels and MBL pathway activity in human plasma or serum
Recently, an association between the presence of antibodies to Saccharomyces cerevisiae (ASCA) and mutations in exon 1 and the promoter region of the mannan binding lectin (MBL) gene was described in 58 patients with Crohns disease (CD).1 A possible link between ASCA and MBL mutations in patients with CD is plausible. MBL is a component of the innate immune system that can bind to S cerevisiae and the serum concentration of MBL … ...
With enhanced promotor, Mannan Binding Lectin / MBL2 cDNA ORF Clone, Mouse in pCMV3-C-OFPSpark is expression-ready, and confirmed by full-length sequence & expression validation
Your trusted lab partner for Mannan Binding Lectin (MBL) testing, Viracor Eurofins delivers your results faster, when it matters most.
Mannose binding lectin (MBL) is an important host defence protein against opportunistic fungal pathogens. This carbohydrate-binding protein, an opsonin and lectin pathway activator, binds through multiple lectin domains to the repeating sugar arrays displayed on the surface of a wide range of clinically relevant microbial species. We investigated the contribution of MBL to antifungal innate immunity towards C. parapsilosis in vitro. High avidity binding was observed between MBL and C. albicans and C. parapsilosis. Addition of MBL to MBL deficient serum increased the deposition of C4 and C3b and enhanced the uptake of C. albicans, C. parapsilosis and acapsular C. neoformans by polymorphonuclear cells (PMNs). Compared to other microorganisms, such as Escherichia coli, Staphylococcus aureus and Cryptococcus neoformans, C. parapsilosis and Candida albicans were potent activators of the lectin pathway. Our results suggest that MBL plays a crucial role in the innate immunity against infections caused by yeast
Individuals with low levels of mannan-binding lectin (MBL) appear to be susceptible to infectious diseases. This suggests that substitution therapy with MBL might be a beneficial treatment of patients with MBL deficiency. A production process for an MBL product has been developed from a fraction II+III precipitate obtained by ethanol fractionation of plasma. The MBL process includes three chromatographic steps, where the first and key step is affinity chromatography on a cross-linked agarose matrix selecting for oligomeric, carbohydrate-binding MBL. The yield from the production process is about 25% of the plasma MBL content, and the purity is about 65%. The MBL product shows mannan-binding activity and complement-activating ability. A safety study has shown this plasma-derived MBL to be safe and well tolerated in adult MBL-deficient volunteers. ...
Research abstract: Chronic fatigue syndrome (CFS) is a severe disease characterized by various symptoms of immune dysfunction. CFS onset is typically with an infection and many patients suffer from frequently recurrent viral or bacterial infections. Immunoglobulin and mannose binding lectin … Continue reading →. ...
Atherosclerosis is a chronic inflammatory disorder that is characterized by the accumulation of modified lipoproteins in the arterial intima. C1q and mannan-binding lectin (MBL) are not only recognition components involved in activation of inflammation via the complement cascade, but they are also able to directly modulate phagocyte activation. Studies in C1q−/− and MBL−/− mice suggest that these molecules play a protective role in the early atherosclerotic lesion in the absence of, or prior to, expression of other complement components. However, in later stages, complement activation becomes an inappropriate inflammatory response, contributing to disease pathology. Therefore, to investigate possible molecular interactions of C1q and MBL in atherosclerotic lesions, we examined the influence of C1q and MBL in the clearance of native and modified lipoproteins by human monocytes and monocyte-derived macrophages. Both C1q and MBL are shown to bind and enhance the monocyte/monocyte-derived ...
Mannose molecules signal acute responses to the immune system. Mannan binding proteins are essential to recognize, signal, and activate the immune system
Looking for immune conglutinin? Find out information about immune conglutinin. A heat-stable substance in bovine and other serums that aids or causes agglomeration or lysis of certain sensitized cells or particles Explanation of immune conglutinin
TY - JOUR. T1 - Solid phase enzyme immunoassay or radioimmunoassay for the detection of immune complexes based on their recognition by conglutinin. T2 - conglutinin binding test. A comparative study with 125I labelled C1q binding and Raji cell RIA tests. AU - Casali, P.. AU - Bossus, A.. AU - Carpentier, N. A.. AU - Lambert, P. H.. PY - 1977/12/1. Y1 - 1977/12/1. N2 - Bovine conglutinin was used in a solid-phase assay for the detection of immune complexes. In a first step, the tested serum sample is incubated in polypropylene tubes coated with conglutinin to allow C3-coated immune complexes to bind to solid-phase conglutinin. In a second step, the conglutinin-bound complexes are detected using an enzyme-conjugated or radiolabelled antiimmunoglobulin antibody. The conglutinin-binding (KgB) test does not suffer from the interference of DNA, heparin or endotoxins. Its limit of sensitivity for aggregated IgG is 3 μg/ml undiluted human serum. Immune complexes prepared in vitro using tetanus toxoid, ...
Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable. Spin down and send 1 mL of serum frozen in a plastic vial.
Mannan-Binding lectin (MBL) is a serum lectin and an important constituent of the innate immune system. Processes linked to the innate immune response have previously been implicated in Alzheimers disease (AD). MBL is associated with blood vessels in the brain and AD patients demonstrate lower MBL levels in the cerebrospinal fluid compared to controls. We investigated six single nucleotide polymorphisms, linked to MBL deficiency, in the corresponding MBL2 gene in AD patients and controls. Two MBL2 haplotypes, LXP and LYQ, were significantly associated with AD risk (OR = 1.6, p = 0.01 and OR = 1.5, p = 0.02, respectively). The present study is the first investigating MBL2 genotypes and haplotypes in relation to AD. Our findings support that the MBL2 gene impact the disease risk.
ASCA can also be inherited, much like a gluten allergy is inherited in Celiacs. There appears to be a genetic predispostion in Crohns and Behcets disease. There have been several studies finding ASCA in healthy relatives of these patients. Whats more, the genetic mechanism that may be responsible is something called Mannan Binding Lectin (MBL) deficiency. Mannan Binding Lectins are a part of the Innate Immune System. They look similar to bouquets of tulips. The tulip portion is designed to latch on to the carbohydrate surface of yeasts and certain bacteria. Once latched on they can sweep the particle away or call out to other components of the immune sytem to help with disposal. Roughly 55 percent, or so, of the population has adequate MBL, about 40 percent of so are lower on MBL and roughly 5-10 percent are deficient. When an individual is low, another part of the immune system steps in to take up the slack, and its usually antibodies that do this. And if I understand correctly (again, I ...
ASCA can also be inherited, much like a gluten allergy is inherited in Celiacs. There appears to be a genetic predispostion in Crohns and Behcets disease. There have been several studies finding ASCA in healthy relatives of these patients. Whats more, the genetic mechanism that may be responsible is something called Mannan Binding Lectin (MBL) deficiency. Mannan Binding Lectins are a part of the Innate Immune System. They look similar to bouquets of tulips. The tulip portion is designed to latch on to the carbohydrate surface of yeasts and certain bacteria. Once latched on they can sweep the particle away or call out to other components of the immune sytem to help with disposal. Roughly 55 percent, or so, of the population has adequate MBL, about 40 percent of so are lower on MBL and roughly 5-10 percent are deficient. When an individual is low, another part of the immune system steps in to take up the slack, and its usually antibodies that do this. And if I understand correctly (again, I ...
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PE/Cyanine7 anti-mouse CD93 (AA4.1, early B lineage) Antibody - CD93 is a 130-140kD C-type lectin-like type I transmembrane protein, also known as complement component 1, q subcomponent (C1qR1), C1qRp collectin receptor (C1qRp), or AA4 antigen.
Phagocytosis of microbes is a major innate host defense that limits the growth and spread of pathogens. Phagocytes appear rapidly at sites of infection in conjunction with the initiation of inflammation. Ingestion of microbes by both tissue-fixed macrophages and migrating phagocytes probably accounts for the limited ability of most microbial agents to cause disease.A family of related molecules called collectins, soluble defense collagens, or pattern-recognition molecules are found in blood (mannose-binding lectins), in lung (surfactant proteins A and D), and most likely in other tissues as well and bind to carbohydrates on microbial surfaces to promote phagocyte clearance. Bacterial pathogens seem to be ingested principally by polymorphonuclear neutrophils (PMNs), whereas eosinophils are frequently found at sites of infection with protozoan or multicellular parasites. Successful pathogens, by definition, must avoid being cleared by professional phagocytes. One of several antiphagocytic ...
Purified Recombinant Human MBL2 Protein, MYC/DDK-tagged from Creative Biomart. Recombinant Human MBL2 Protein, MYC/DDK-tagged can be used for research.
Collagens and proteins with collagen-like domains form large superfamilies in various species, and the numbers of known family members are increasing constantly. Vertebrates have at least 27 collagen types with 42 distinct polypeptide chains, |20 additional proteins with collagen-like domains and …
WLAN-Repeater N Mbps, 2,4GHz Operating Instructions Bedienungsanleitung GB D Signal WLAN Power WPS LAN WPS man.indd :28 G User manual WLAN 300 Mbps Repeater Contents
When I first joined plusnet, around 10 years ago, I got 15-17mbps on my line. Over time this reduced to 12-14mbps and stayed that way for quite some
Mannan Binding Lectin (MBL) is a member of the lectin pathway of the complement system and plays an important role in the innate immune system. MBL replacement in MBL-deficient children with chemotherapy-induced neutropenia represents a new approach to lower the risk of febrile episodes, of hospital admission, of prolonged use of intravenous antibiotics and of severe infections.. The aim of the Phase II study is to find evidence for the correct prediction of plasma levels of MBL necessary for clinical effects and biological efficacy, to confirm the dosage regimen needed to reach the required MBL plasma levels, and reconfirm the safety and lack of side-effects. ...
Mannose binding lectin (MBL) is a calcium-dependent lectin that plays an important role innate immunity by activating the complement pathway. There have been a number of studies describing an association between the MBL genotype and disease susceptibility. ...
Background: There have been studies focused on mannose binding lectin (MBL) polymorphism and susceptibility to recurrent respiratory tract infections (RRTI) with inconclusive results. This present study is a meta-analysis of possible MBL and RRTI association in children. ...
The ficolins share a common organization and function with the collectins: serum mannose-binding and the pulmonary surfactant proteins A and D. All of these proteins are soluble mediators of innate immunity and consist of globular sugar-binding domains attached to collagenous stalks, which can invoke innate immune responses either through complement fixation or interaction with receptors on the surfaces of macrophages. Amongst these proteins, the ficolins have been most extensively investigated with CFG resources, while mannose-binding protein is the best characterized. The ficolins have fibrinogen-like sugar-binding domains, rather than C-type carbohydrate-recognition domains, but conceptually fall within the same group. See also: paradigm page for Ficolin M (Ficolin 1) ...
The ficolins share a common organization and function with the collectins: serum mannose-binding and the pulmonary surfactant proteins A and D. All of these proteins are soluble mediators of innate immunity and consist of globular sugar-binding domains attached to collagenous stalks, which can invoke innate immune responses either through complement fixation or interaction with receptors on the surfaces of macrophages. Amongst these proteins, the ficolins have been most extensively investigated with CFG resources, while mannose-binding protein is the best characterized. The ficolins have fibrinogen-like sugar-binding domains, rather than C-type carbohydrate-recognition domains, but conceptually fall within the same group. See also: paradigm page for Ficolin M (Ficolin 1) ...
(lek tin) The lectin pathway for complement activation is triggered by the binding of a serum lectin (mannan binding lectin; MBL) to mannose containing proteins or to carbohydrates on viruses or bacteria
The pulmonary collectins, surfactant proteins A (SP-A) and D (SP-D), have been reported to bind lipopolysaccharide (LPS), opsonize microorganisms, and enhance the clearance of lung pathogens. In this study, we examined the effect of SP-A and SP-D on the growth and viability of Gram-negative bacteria. The pulmonary clearance of Escherichia coli K12 was reduced in SP-A-null mice and was increased in SP-D-overexpressing mice, compared with strain-matched wild-type controls. Purified SP-A and SP-D inhibited bacterial synthetic functions of several, but not all, strains of E. coli, Klebsiella pneumoniae, and Enterobacter aerogenes. In general, rough E. coli strains were more susceptible than smooth strains, and collectin-mediated growth inhibition was partially blocked by coincubation with rough LPS vesicles. Although both SP-A and SP-D agglutinated E. coli K12 in a calcium-dependent manner, microbial growth inhibition was independent of bacterial aggregation. At least part of the antimicrobial ...
Gene Information The ficolin family of proteins are characterized by the presence of a leader peptide a short N-terminal segment followed by a collagen-like region and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q C-type lectins known as collectins and tenascins. However all these proteins recognize different targets and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq Jul 2008]. ...
MBL : Evaluation of children and adults with a clinical history of recurrent infections Results may be useful for genetic counseling and support aggressive management of recurrent infections in patients with reduced levels of mannose-binding lectin
My daughter was just diagnosed with a MBL (mannose-binding lectin) deficiency. She is 6 years old now and has been plagued by multiple pneumonias and sinus infections. What is the prognosis of this def...
Eisen, Damon P., Dean, Melinda M., Boermeester, Marja A., Fidler, Katy J., Gordon, Anthony C., Kronborg, Gitte, Kun, Jürgen F.J., Lau, Yu Lung, Payeras, Antonis, Valdimarsson, Helgi, Brett, Stephen J., Mila, Joan, Ip, W.K. Eddie, Peters, Mark J., Saevarsdottir, Saedis, van Till, J.W. Oliver, Hinds, Charles J., and McBryde, Emma S. (2008) Low serum mannose‐binding lectin level increases the risk of death due to pneumococcal infection. Clinical Infectious Diseases, ...
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2BGO: Structure of a Mannan-Specific Family 35 Carbohydrate-Binding Module: Evidence for Significant Conformational Changes Upon Ligand Binding
Background: Mannose-binding lectin is a collectin involved in host defense against infection. Whether mannose-binding lectin deficiency is associated with acute exacerbations of chronic obstructive pulmonary disease is debated. Methods: Participants in a ...
Console gaming requires a TON of bandwidth, especially with the next-gen systems. A single Xbox One game for example can be 50 gigabytes or larger between the base game and all the updates and add-ons. at 10 mbps we are talking 11+ hours to download! Yeah Verizon, im sure your customers are going to be completely fine with waiting 11+ hours to download a game they purchased, since you dont think they need any faster speeds ...
802.11a operates at data rates up to 54 Mbps; 802.11b has a maximum data rate of 11 Mbps. Actual application throughput is typically about half of the data rate due to overhead. For a more detailed comparison of these two WLAN radio standards, read this searchNetworking tip: Choosing Between 802.11a and 802.11b ...
The TUSB2046x is a 3.3-V CMOS hub device that provides one upstream port and four downstream ports in compliance with the Universal Serial Bus (USB) specification as a full-speed hub.
Vol II: Letters and Buddhist". Khalili Collectins: 19. "Afghan and Afghanistan". Abdul Hai Habibi. alamahabibi.com. 1969. ... Vol II: Letters and Buddhist". Khalili Collectins: 19. Noelle-Karimi, Christine; Schetter, Conrad J.; Schlagintweit, Reinhard ( ...
Bowman, Julie (September 1, 2012). "Tujin Nars: A Story of the Forest". SIT Digital Collectins. SIT Graduate Institute. ...
SP-A2 is a member of a subfamily of C-type lectins called collectins. Together with (surfactant protein A1 ) SP-A1, they are ... Stuart GR, Lynch NJ, Day AJ, Schwaeble WJ, Sim RB (December 1997). "The C1q and collectin binding site within C1q receptor ( ... Crouch EC (August 1998). "Collectins and pulmonary host defense". American Journal of Respiratory Cell and Molecular Biology. ... Crouch E, Hartshorn K, Ofek I (February 2000). "Collectins and pulmonary innate immunity". Immunological Reviews. 173: 52-65. ...
SP-A1 is a member of a subfamily of C-type lectins called collectins. Together with SP-A2, they are the most abundant proteins ... Crouch EC (Aug 1998). "Collectins and pulmonary host defense". American Journal of Respiratory Cell and Molecular Biology. 19 ( ... Crouch E, Hartshorn K, Ofek I (Feb 2000). "Collectins and pulmonary innate immunity". Immunological Reviews. 173: 52-65. doi: ... Lu J (Jun 1997). "Collectins: collectors of microorganisms for the innate immune system". BioEssays. 19 (6): 509-18. doi: ...
In 2009, he co-founded "The Collectin" with his friend Zoë Worth, a group of New York actors, writers, producers and directors ... "Collectin Consciousness". Interview. July 12, 2010. Sancton, Julian (April 7, 2010). "Alden Ehrenreich's Magic Show". Vanity ...
Barcelona: Interface Collectin. p. 88. Herbert, Kadison (1946). Flamenco Firebrand. Greenwich Village Chatter. pp. 5-7. Clement ...
SP-A and SP-D are collectins. They confer innate immunity as they have carbohydrate recognition domains that allow them to coat ...
Hansen S, Holmskov U (August 1998). "Structural aspects of collectins and receptors for collectins". Immunobiology. 199 (2): ... is a lung surfactant protein part of the collagenous family of proteins called collectin. In humans, SP-D is encoded by the ...
... lectin which are named collectins. The collectins are responsible for immune and inflammatory control. They have a very basic ...
... is an innate immune system collectin. It is water-soluble and has collagen-like domains similar to SP-D. ...
Members of every class of pathogen that infect humans also infect plants. Although the exact pathogenic species vary with the infected species, bacteria, fungi, viruses, nematodes, and insects can all cause plant disease. As with animals, plants attacked by insects or other pathogens use a set of complex metabolic responses which lead to the formation of defensive chemical compounds that fight infection or make the plant less attractive to insects and other herbivores.[33] (see: plant defense against herbivory). Like invertebrates, plants neither generate antibody or T-cell responses nor possess mobile cells that detect and attack pathogens. In addition, in case of infection, parts of some plants are treated as disposable and replaceable, in ways that very few animals are able to do. Walling off or discarding a part of a plant helps stop spread of an infection.[33] Most plant immune responses involve systemic chemical signals sent throughout a plant. Plants use pattern-recognition receptors to ...
CS1 maint: discouraged parameter (link) Black Borders Collectin of 32 Cameos. pa.: Saadat Hasan., Rakhshanda Jalil Manto: ...
Maurice Tallon made collectins of flint and pottery from the area dating to various periods. These included an incised sherd ...
Collectins (e.g. mannose-binding lectin and surfactant protein A) bind the altered surface sugars on apoptotic cell and enable ... C1q and collectins are other PRRs which could potentially recognize both PAMPs and ACAMPs structures. It is necessary to ... They can also be seen as secreted forms of pattern recognition receptors (PRRs).7 These include collectins, components of ...
Stuart GR, Lynch NJ, Day AJ, Schwaeble WJ, Sim RB (December 1997). "The C1q and collectin binding site within C1q receptor ( ...
ISBN 978-2-07-038237-8. Also published by Gallimard Education as Ronde Et Autres Faits Divers (La) (Collectin Folio) in a Mass ... ISBN 978-2-07-038237-8. Also published as Ronde Et Autres Faits Divers (La) (Collectin Folio) by Gallimard Education Le Clézio ... Collectin Folio) (Mass Market Paperback) (in French). Paris: Editions Flammarion. p. 281. ...
Some other genes encoding cell adhesion molecules including CDH26, collectins and gelectins are up-regulated in infected ...
These include secretory immunoglobulins (IgA), collectins, defensins and other peptides and proteases, reactive oxygen species ...
As result the collectin was published in Zagreb in 1861, and it was dedicated to Strosmayer. The book represents an anthology ...
The CL-K1 protein is a C-type lectin, and belongs to the collectin family of these proteins. Other than its role in innate ...
van de Wetering JK, van Golde LMG, Batenburg JJ (2004). "Collectins Players of the innate immune system". Eur J Biochem 271: ... comparison with serum collectins". Am J Physiol Lung Cell Mol Physiol 273: 1156-1166.. Je zde použita šablona {{Cite journal}} ... Gardai SJ, Yi-Qun Xiao, Dickinson M (2003). "By Binding SIRP� or Calreticulin/CD91, Lung Collectins Act as Dual Function ... Calreticulin and CD91 as a Common Collectin Receptor Complex". J Immunol 169: 3978-86.. Je zde použita šablona {{Cite journal}} ...
One very important collectin is mannan-binding lectin (MBL), a major PRR of the innate immune system that binds to a wide range ... Complement receptors, collectins, ficolins, pentraxins such as serum amyloid and C-reactive protein, lipid transferases, ...
Like collectins (Col+lectin) such as mannan-binding lectin, ficolins are secreted, lectin-type (soluble) pattern recognition ...
Collectin molecules such as mannose-binding lectin (MBL), surfactant protein A (SP-A), and SP-D interact with unknown ligands ... Mannose-binding lectins, or ficolins, along with pentraxins and collectins are able to recognize certain types of carbohydrates ...
... known together as collectins, are more distinct from SP-B than SP-C. They are hydrophilic, so they are found in the solution, ...
MBL belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in ...
... while the former is also found in complement protein C1q and collectins, which include mannose-binding lectin and lung ...
Collectins Mannan-binding lectin (MBL) Surfactant protein A (SP-A) Surfactant protein D (SP-D) CL-L1 CL-P1 CL-K1 Peptidoglycan ...
... and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A". J ...
... with Quelle Chris Collectin' Dust (2012) Throwbacks (2012) Llamaville (2012) 10K (2013) Progressions (2013) Up the Joystick 2 ( ...
... collectin liver 1 CL-P1 = collectin placenta 1 CL-43 = conglutinin collectin of 43 kDa CL-46 = collectin of 46 kDa CL-K1 = ... Collectins SP-A and SP-D enhance clearance of apoptotic cells by macrophages. Collectins are linked with activation of lectin ... Collectins can act as opsonins. There is a specific interaction between collectins and receptors on phagocytic cells which can ... At the beginning, there is a binding of collectin to PAMPs or DAMPs. Collectin MBL is involved in activation of the lectin ...
Collectin-12, also known as collectin subfamily member 12, is a collectin protein that in humans is encoded by the COLEC12 gene ... "Entrez Gene: Collectin subfamily member 12". Retrieved 2019-12-24. Ohmori H, Makita Y, Funamizu M, Chiba S, Ohtani K, Suzuki Y ... Selman L, Skjodt K, Nielsen O, Floridon C, Holmskov U, Hansen S (June 2008). "Expression and tissue localization of collectin ... This gene encodes a member of the collectin family, proteins that possess collagen-like sequences and carbohydrate recognition ...
IPR033990 Collectin_CTLD. IPR016187 CTDL_fold. Pfami. View protein in Pfam. PF01391 Collagen, 2 hits. PF00059 Lectin_C, 1 hit ... "Molecular cloning of a novel human collectin from liver (CL-L1).". Ohtani K., Suzuki Y., Eda S., Kawai T., Kase T., Yamazaki H. ... "Molecular cloning of a novel human collectin from liver (CL-L1).". Ohtani K., Suzuki Y., Eda S., Kawai T., Kase T., Yamazaki H. ... "Molecular cloning of a novel human collectin from liver (CL-L1).". Ohtani K., Suzuki Y., Eda S., Kawai T., Kase T., Yamazaki H. ...
Here, we identify collectin CL-LK as a novel soluble C-type lectin able to bind M. tuberculosis, and characterize mycobacterial ...
All of the collectins enhanced IAV binding to neutrophils; however, in the case of MBL, this effect was modest compared with ... Mechanisms of anti-influenza activity of surfactant proteins A and D: comparison with serum collectins.. Hartshorn KL1, White ... The present study provides the first direct comparison of anti-influenza A virus (IAV) activities of the collectins surfactant ... for viral inhibition by SP-D and reveal significant differences in the mechanisms of anti-IAV activity among the collectins. ...
Here, we have described how the recently discovered C-type lectin collectin-11 (CL-11, also known as CL-K1 and encoded by ... Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury. ... Collectin-11 detects stress-induced L-fucose pattern to trigger renal epithelial injury. ...
Other members of the collectin family, including human surfactant protein D, bovine collectin-43, and conglutinin also showed ... Interactions of the Extracellular Matrix Proteoglycans Decorin and Biglycan with C1q and Collectins. Tom W. L. Groeneveld, ... These two proteoglycans are likely to down-regulate proinflammatory effects mediated by C1q, and possibly also the collectins, ... Interactions of the Extracellular Matrix Proteoglycans Decorin and Biglycan with C1q and Collectins ...
Conglutinin and CL-43, two collagenous C-type lectins (collectins) in bovine serum Jens Chr. Jensenius; Jens Chr. Jensenius ... Jensenius, Steen B. Laursen, Yupei Zheng, Uffe Holmskov; Conglutinin and CL-43, two collagenous C-type lectins (collectins) in ...
Collectins and cationic antimicrobial peptides are antimicrobial components of the pulmonary innate immune system produced by ... Collectins and cationic antimicrobial peptides are antimicrobial components of the pulmonary innate immune system produced by ... Grubor, Branka; Meyerholz, David K.; and Ackermann, Mark R., "Collectins and cationic antimicrobial peptides of the respiratory ...
The surfactant-associated protein A (SP-A) belongs to the collectin family, a group of C-type lectins encompassing also ... may mediate anti-microbial activity through binding to carbohydrates on the microorganisms and collectin receptors on ... characteristics of human pulmonary surfactant-associated protein A and comparison with two other collectins: mannan-binding ... characteristics of human pulmonary surfactant-associated protein A and comparison with two other collectins: mannan-binding ...
Collectin-mediated antiviral host defense of the lung: evidence from influenza virus infection of mice.J. Virol. 71 1997 8204 ... Collectins: collagenous C-type lectins of the innate immune defense system.Immunol. Today 15 1994 67 74 ... Collectins-soluble proteins containing collagenous regions and lectin domains-and their role in innate immunity.Protein Sci. 3 ... The collectins are a family of soluble collagenous lectins believed to function in host defense against a variety of ...
Presentation] Pulmonary Collectins Attenuate Autophagy Induce By L.Pneumophila Infection2011. *. Author(s). Saito A, Ariki S, ... Presentation] Pulmonary Collectins Attenuate Autophagy Induce By L.Pneumophila Infection.2011. *. Author(s). Saito S, Takahashi ... to evaluate the protective effect by lung a collectin, SP-A and to establish the molecular basis for the clinical application ... These results indicate that BLM-induced signal depends on TLR2 and lung collectin, SP-A has protective function against ALI via ...
Complement and collectins. The complement system consists of a number of small proteins found in the blood, in general ...
Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease ...
This gene encodes a member of the C-lectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. The other members of this family are secreted proteins and bind to carbohydrate antigens on microorganisms facilitating their recognition and removal. This gene product is a cytosolic protein, a characteristic that suggests that it may have different biological functions than other C-lectins. [provided by RefSeq, Jul 2008 ...
Recently, three novel collectins, collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1 and CL-11), and collectin placenta 1 (CL ... Investigations on Collectin Liver 1. Axelgaard et al., J. Biol. Chem. (2013) - PMID: 23814060. Product(s) used in this ... Investigations on Collectin Liver 1. *The Mtb Proteome Library: A Resource of Assays to Quantify the Complete Proteome of ... Collectins are pattern recognition molecules of the innate immune system showing binding to carbohydrate structures on ...
Collectins and ficolins, present in plasma and on mucosal surfaces, are humoral molecules of the innate immune systems. ... Collectins and Ficolins: Humoral Lectins of the Innate Immune System. ... Collectins and Ficolins: Humoral Lectins of the Innate Immune System Collectins and ficolins, present in plasma and on mucosal ... Collectins and Ficolins: Humoral Lectins of the Innate Immune System. Collectins and Ficolins: Humoral Lectins of the Innate ...
Relaxed Fit Stretch/Plain Jane Jeans...again, you get this if in the 60s you sat in a tub of hot water in your Levis until they shrunk several sizes smaller than your epidermis. After which you wore them while they dried and until they would stand alone when peeled off your body. If that was not your skinny jean era, then you might be a Designer Jeans Gal, when it was any bodies GUESS as to how they figured a tall girl with no butt and no defined waist could fit into those hourglass waists, hippo hips, a wedgie crotch and SitOn Pockets with forked studs and wire stitching ...
There is nothing over here that I do not like! You are a baaaddd influence! LOL! I love it over it! You are a real doll to post my giveaway. There will be more to follow. I am loving meeting all these new friends and as for you I feel like I have known you a while! Plus this post it awesome! My niece Karla collects apples so everywhere I go I buy her apple stuff! Now I will have to think of you and send a pretty red apple piece your way too! Hugs!. ReplyDelete ...
Collectin-1,Homo sapiens,Human,Mannan-binding protein,Mannose-binding lectin,Mannose-binding protein C,MBL,MBL2,MBP1,MBP-C \ ... ELISA COLEC1,Collectin-1,Homo sapiens,Human,Mannan-binding protein,Mannose-binding lectin,Mannose-binding protein C,MBL,MBL2, ... Product name : ELISA COLEC1,Collectin-1,Homo sapiens,Human,Mannan-binding protein,Mannose-binding lectin,Mannose-binding ... Index / EIAab / ELISA COLEC1,Collectin-1,Homo sapiens,Human,Mannan-binding protein,Mannose-binding lectin,Mannose-binding ...
Heteromeric Complexes of Native Collectin Kidney 1 and Collectin Liver 1 Are Found in the Circulation with MASPs and Activate ... During purification and characterization of native CL-K1 from plasma, we observed that collectin liver 1 (CL-L1) was copurified ... or collectin kidney 1 (CL-K1, alias CL-11) to suitable microbial patterns consisting of carbohydrates or acetylated molecules. ...
collectin subfamily member 10. Enable Javascript to view the expand/collapse boxes.. Open All Close All ...
Collectins such as mannose-binding lectin (MBL) and surfactant protein D (SP-D) become temporarily deposited in extravascular ... Immune regulation by fibroblasts in tissue injury depends on uPARAP-mediated uptake of collectins. Publikation: Bidrag til ... When introduced into dermis or bleomycin-injured lungs of mice, collectins MBL and SP-D were endocytosed and routed for ... In this study, we show that fibroblasts in injured tissues undertake the clearance of collectins by using the endocytic ...
Human Placental Gene Expression: Collectins. Tashmay Jones and Raphael Isokpehi. Collectins (collagen-containing C-type lectins ... Within the collectin (COLEC) gene family, there are ten genes. The placenta is the highly specialized but relatively ... The objective of the research study was to determine the expression levels of the individual members within the collectin ... A total of 7 probe sets were analyzed for the collectin gene family. A box plot representation identified probe set "221019_s_ ...
Members of every class of pathogen that infect humans also infect plants. Although the exact pathogenic species vary with the infected species, bacteria, fungi, viruses, nematodes, and insects can all cause plant disease. As with animals, plants attacked by insects or other pathogens use a set of complex metabolic responses which lead to the formation of defensive chemical compounds that fight infection or make the plant less attractive to insects and other herbivores.[33] (see: plant defense against herbivory). Like invertebrates, plants neither generate antibody or T-cell responses nor possess mobile cells that detect and attack pathogens. In addition, in case of infection, parts of some plants are treated as disposable and replaceable, in ways that very few animals are able to do. Walling off or discarding a part of a plant helps stop spread of an infection.[33] Most plant immune responses involve systemic chemical signals sent throughout a plant. Plants use pattern-recognition receptors to ...
Roles Of Collectins In Resisting Allergic Inflammation And Hypersensitivity Induced By Fungal Allergens And Antigens. Last ...
collectin-1. *HSMBPC. *mannan-binding lectin. *mannose-binding lectin (protein C) 2, soluble ...
The COLEC11 gene provides instructions for making a protein called collectin kidney 1 (CL-K1). This protein is involved in a ... Selman L, Hansen S. Structure and function of collectin liver 1 (CL-L1) and collectin 11 (CL-11, CL-K1). Immunobiology. 2012 ... Genetic variation of COLEC10 and COLEC11 and association with serum levels of collectin liver 1 (CL-L1) and collectin kidney 1 ... Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate ...
Fingerprint Dive into the research topics of Protective role of the lung collectins surfactant protein A and surfactant ... Protective role of the lung collectins surfactant protein A and surfactant protein D in airway inflammation. ...
Development of Chimeric Collectins with Enhanced Activity Against Influenza a Virus Kevan L. Hartshorn, Mitchell R. White, R. ... Pattern Recognition, Receptors and Collectins in Innate Immunity. * Mannose Receptor and Scavenger Receptor: Two Macrophage ...
  • Nine types of collectins have been defined: MBL = mannan-binding lectin (mannose-binding lectin) SP-A = surfactant protein A SP-D = surfactant protein D CL-L1 = collectin liver 1 CL-P1 = collectin placenta 1 CL-43 = conglutinin collectin of 43 kDa CL-46 = collectin of 46 kDa CL-K1 = collectin kidney 1 Conglutinin CL-43, CL-46 and conglutinin are found in bovine. (wikipedia.org)
  • Mechanisms of anti-influenza activity of surfactant proteins A and D: comparison with serum collectins. (nih.gov)
  • The present study provides the first direct comparison of anti-influenza A virus (IAV) activities of the collectins surfactant protein (SP) A and SP-D, mannose-binding lectin (MBL), and conglutinin. (nih.gov)
  • Other members of the collectin family, including human surfactant protein D, bovine collectin-43, and conglutinin also showed binding to decorin and biglycan. (jimmunol.org)
  • The surfactant-associated protein A (SP-A) belongs to the collectin family, a group of C-type lectins encompassing also surfactant-associated protein D, mannan-binding protein (MBP) and conglutinin. (biochemj.org)
  • A/Phil/82 and A/HKx31 are sensitive to neutralization in vitro by the pulmonary collectin surfactant protein D (SP-D), whereas A/PR/8/34 is essentially resistant. (asm.org)
  • Our recent studies with mice have indicated an important role for collectins, in particular lung surfactant protein D (SP-D), in innate defense against influenza virus ( 20 ). (asm.org)
  • The human collectins, mannan-binding lectin (MBL) and surfactant protein A and D (SP-A and SP-D), are oligomeric proteins composed of carbohydrate-recognition domains (CRDs) attached to collagenous regions and are thus structurally similar to the ficolins, L-ficolin, M-ficolin, and H-ficolin. (sinobiological.com)
  • Collectins such as mannose-binding lectin (MBL) and surfactant protein D (SP-D) become temporarily deposited in extravascular compartments after tissue injury and perform immune-stimulatory or inflammation-limiting functions. (regionh.dk)
  • This finding contrasted with results obtained with surfactant protein D (SP-D). Unlike collectins or human neutrophil defensins (HNPs), LL-37 did not induce viral aggregation under electron microscopy. (nih.gov)
  • The pulmonary collectins and surfactant metabolism. (ucdavis.edu)
  • The collectins are soluble lectins containing collagen-like regions which are found in plasma and in the lung surfactant. (go.jp)
  • 2003). "Direct binding of Toll-like receptor 2 to zymosan, and zymosan-induced NF-kappa B activation and TNF-alpha secretion are down-regulated by lung collectin surfactant protein A". J. Immunol. (wikipedia.org)
  • Surfactant Protein D (SP-D) is a collectin family protein consisting of a collagen-like sequence followed by a C-type lectin domain. (rndsystems.com)
  • Three collectins are known in humans: mannan-binding lectin (MBL), a serum protein, and the lung surfactant proteins A and D (SP-A and SP-D), which are produced by epithelial cells mainly in the lung. (pnas.org)
  • In the absence of serum opsonins, competitive inhibition of mannose receptor (MR) activity on MDM with mannan decreased the association of F. novicida and opsonization of F. novicida with lung collectin surfactant protein A (SP-A) increased bacterial association and intracellular survival. (asm.org)
  • The complement cascade may be initiated downstream of the lectin activation pathway upon binding of mannan-binding lectin, ficolins, or collectin kidney 1 (CL-K1, alias CL-11) to suitable microbial patterns consisting of carbohydrates or acetylated molecules. (forskningsdatabasen.dk)
  • These include TLRs, lectin-like receptors, serum antimicrobial molecules, natural Abs, complement proteins, and collectins that include mannose-binding lectin (MBL), 5 also known as mannose-binding protein or mannan-binding lectin ( 1 , 2 , 3 ). (jimmunol.org)
  • Data show that the concentration of collectin (show MBL2 ELISA Kits ) kidney 1 (show ZNF354A ELISA Kits ) ( CL-K1 , COLEC11 ) in plasma was 0.34 +/- 0.13 microg/ml and that in mannan-binding lectin (MBL (show MBL2 ELISA Kits )) was 1.72 +/- 1.51 microg/ml. (antibodies-online.com)
  • Polymorphisms of MBL2 and MASP2 genes were investigated and serial measurements of serum concentrations of mannose-binding lectin (MBL), CL-LK collectin and MASP-2 as well as activities of MBL-MASP-1 and MBL-MASP-2 complex were made. (cdc.gov)
  • Here we provide evidence that C1q and mannose binding lectin (MBL), a member of the collectin family of proteins, bind to apoptotic cells and stimulate ingestion of these by ligation on the phagocyte surface of the multifunctional protein, calreticulin (also known as the cC1qR), which in turn is bound to the endocytic receptor protein CD91, also known as the α-2-macroglobulin receptor. (rupress.org)
  • In complex with mannose-binding lectin-associated serine proteases (MASPs), collectin-11 may initiate the activation of complement, playing a role against pathogens, including T. cruzi. (cdc.gov)
  • Mannose-binding lectin (MBL), a serum protein belonging to the collectin family, is considered to be a pattern recognition molecule designed to detect pathogen-associated molecular patterns ( 5 ). (asm.org)
  • The Mannose-binding Lectin pathway is activated by oligosaccharide binding collectin proteins. (scirp.org)
  • Collectin subfamily member 10 (C-type lectin). (cdc.gov)
  • Collectin subfamily member 10 ( COLEC10 ) encodes for collectin liver 1 (CL-L1), which is highly expressed in normal liver. (dovepress.com)
  • This gene encodes a member of the collectin family, proteins that possess collagen-like sequences and carbohydrate recognition domains. (wikipedia.org)
  • Collectins and ficolins can also function as opsonins, which require interaction of these proteins with phagocyte receptors. (sinobiological.com)
  • Collectins, also known as defense collagens, are a multifunctional family of proteins with C-type lectin domains and pattern recognition capability thought to be involved in the role of the innate immune system in protection from infectious organisms ( 1 )( 2 ). (rupress.org)
  • Collectins are oligomeric proteins composed of C type lectin domains connected to collagen regions ( 1 ). (pnas.org)
  • It can be activated by collectin proteins which recognize the structural pattern of polysaccharide on the surface of microorganisms. (scirp.org)
  • Recently, three novel collectins, collectin liver 1 (CL-L1), collectin kidney 1 (CL-K1 and CL-11), and collectin placenta 1 (CL-P1), were discovered. (jpt.com)
  • Bayarri-Olmos R, Hansen S, Henriksen ML, Storm L, Thiel S, Garred P, Munthe-Fog L. Genetic variation of COLEC10 and COLEC11 and association with serum levels of collectin liver 1 (CL-L1) and collectin kidney 1 (CL-K1). (medlineplus.gov)
  • It seems likely that SP-A, like MBP and conglutinin, may mediate anti-microbial activity through binding to carbohydrates on the microorganisms and collectin receptors on phagocytic cells. (biochemj.org)
  • Collectin-12, also known as collectin subfamily member 12, is a collectin protein that in humans is encoded by the COLEC12 gene. (wikipedia.org)
  • The COLEC11 gene provides instructions for making a protein called collectin kidney 1 (CL-K1). (medlineplus.gov)
  • Collectins (collagen-containing C-type lectins) are a part of the innate immune system. (wikipedia.org)
  • The collectins are a family of soluble collagenous lectins believed to function in host defense against a variety of microorganisms ( 8 , 12 , 13 ). (asm.org)
  • C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins [ PMID: 15476922 ]. (ebi.ac.uk)
  • Here, we have described how the recently discovered C-type lectin collectin-11 (CL-11, also known as CL-K1 and encoded by COLEC11 ) recognizes an abnormal pattern of L-fucose on postischemic renal tubule cells and activates a destructive inflammatory response. (jci.org)
  • In this study, collectin-11 plasma levels and COLEC11 variants in exon 7 were assessed in a Brazilian cohort of 251 patients with chronic CD and 108 healthy controls. (cdc.gov)
  • Collectins are soluble pattern recognition receptors (PRRs). (wikipedia.org)
  • Collectin-11 is a multifunctional soluble PRM lectin, widely distributed throughout the body, with important participation in host defense, homeostasis, and embryogenesis. (cdc.gov)
  • There is a specific interaction between collectins and receptors on phagocytic cells which can lead to increased clearance of microorganisms. (wikipedia.org)
  • The purpose of this project were to clarify the mechanism of regulation by which Toll-like receptors (TLRs) act against drug-induced acute lung injury (ALI), to evaluate the protective effect by lung a collectin, SP-A and to establish the molecular basis for the clinical application of it. (nii.ac.jp)
  • Collectins and ficolins have been reported to promote phagocytosis of various microorganisms, either directly after binding to microbes, or indirectly through upregulation of phagocytosis mediated by other phagocytic receptors. (sinobiological.com)
  • Among these receptors, calreticulin and C1qRp have been shown to bind to multiple collectins. (sinobiological.com)
  • C1qRp is a receptor that mediates immobilized collectin-induced upregulation of phagocytosis through complement and Fc receptors. (sinobiological.com)
  • During purification and characterization of native CL-K1 from plasma, we observed that collectin liver 1 (CL-L1) was copurified. (forskningsdatabasen.dk)
  • Henriksen ML, Brandt J, Andrieu JP, Nielsen C, Jensen PH, Holmskov U, Jorgensen TJ, Palarasah Y, Thielens NM, Hansen S. Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system. (medlineplus.gov)
  • Selman L, Hansen S. Structure and function of collectin liver 1 (CL-L1) and collectin 11 (CL-11, CL-K1). (medlineplus.gov)
  • In cellular assays, several types of collectins were endocytosed in a highly specific uPARAP-dependent process, not shared by the closely related receptor MR/CD206. (regionh.dk)
  • Binding of collectins to microorganisms may trigger elimination of microorganisms by aggregation, complement activation, opsonization, activation of phagocytosis, or inhibition of microbial growth. (wikipedia.org)
  • Binding of collectins and ficolins to microbes through the lectin domains leads to activation of multiple immunological processes such as complement activation and phagocytosis. (sinobiological.com)
  • After I moved to King's College London, I focused on studying: 1) how C5a/C5aR1 signaling mediates the expression of carbohydrate ligands on renal tubules in acute pyelonephritis, 2) how collectin 11 increases acute kidney injury and promotes the development of renal fibrosis, 3) how collectin 11 regulates the phagocytosis and cytokine production of retinal pigment epithelial cells, and 4) the roles of collectin 11 in regulating arthritis. (ncl.ac.uk)
  • Collectins and cationic antimicrobial peptides are antimicrobial components of the pulmonary innate immune system produced by respiratory epithelia, which have integral roles in host defense and inflammation in the lung. (iastate.edu)
  • Collectins and pulmonary innate immunity. (semanticscholar.org)
  • Collectin MBL is involved in activation of the lectin complement pathway. (wikipedia.org)
  • Collectins are pattern recognition molecules of the innate immune system showing binding to carbohydrate structures on microorganisms in a calcium-dependent manner. (jpt.com)
  • Collectins and ficolins, present in plasma and on mucosal surfaces, are humoral molecules of the innate immune systems, which recognize pathogen-associated molecular patterns. (sinobiological.com)
  • Other functions of collectins are modulation of inflammatory, allergic responses, adaptive immune system and clearance of apoptotic cells. (wikipedia.org)
  • Collectins SP-A and SP-D enhance clearance of apoptotic cells by macrophages. (wikipedia.org)
  • Collectins can bind to the surface of microorganisms and between carbohydrate ligands. (wikipedia.org)
  • The collectins play an important role in innate immunity by binding to specific carbohydrate structures found on the surfaces of pathogenic microorganisms, including bacteria, viruses, yeasts, and parasitic protozoa. (pnas.org)
  • Like the other collectins, SP-D binds to repeating carbohydrate moieties on pathogenic microorganisms and is considered to be a pattern-recognition molecule of the innate immune system ( 3 ). (pnas.org)
  • However, they make use of different CRD structures: C-type lectin domains for the collectins and fibrinogen-like domains for the ficolins. (sinobiological.com)
  • Increased Susceptibility of Diabetic Mice to Influenza Virus Infection: Compromise of Collectin-Mediated Host Defense of the Lung by Glucose? (asm.org)
  • These findings suggest that in mice, and perhaps in humans, diabetes predisposes to influenza virus infection through compromise of collectin-mediated host defense of the lung by glucose. (asm.org)
  • Thus the collectins by virtue of their antibody-independent, carbohydrate recognition properties may play an important role in innate immunity especially in the very young or in those with an inability to produce antibodies. (go.jp)
  • collectin-11 associates with all the known MBL -associated serine proteases ( MASP-1 , MASP-2 and MASP-3 ) as well as the lectin complement pathway regulator MAP-1 . (antibodies-online.com)
  • Collectins have also been shown to modulate leukocyte chemotaxis, proliferation and differentiation. (sinobiological.com)
  • Affinity of interaction between microbes and collectins depends on the degree of collectin oligomerization and also on the density of ligands on the surface of the microbe. (wikipedia.org)
  • Collectins are linked with activation of lectin pathway of complement activation. (wikipedia.org)
  • BML bound directly with sTLR2 and its binding was blocked by SP-A. These results indicate that BLM-induced signal depends on TLR2 and lung collectin, SP-A has protective function against ALI via TLR2 dependent signal pathway. (nii.ac.jp)
  • C1q, a member of the first component of the classical complement pathway, is related to this family as it shares structural and functional homology with the collectins, although it does not exhibit lectin activity ( 3 ). (rupress.org)
  • In this study, we show that fibroblasts in injured tissues undertake the clearance of collectins by using the endocytic collagen receptor uPARAP. (regionh.dk)
  • These two proteoglycans are likely to down-regulate proinflammatory effects mediated by C1q, and possibly also the collectins, at the tissue level. (jimmunol.org)
  • Data suggest that collectin 11 (CL-11), e.g. via complement, may play a role in response to particles and surfaces presenting extracellular DNA, such as apopototic cells. (antibodies-online.com)
  • These studies clarify the structural requirements for viral inhibition by SP-D and reveal significant differences in the mechanisms of anti-IAV activity among the collectins. (nih.gov)
  • Collectins SP-A and SP-D have anti-allergic effects: they inhibit IgE binding to allergens, decrease histamine release from basophils, and inhibit T-lymphocyte production in the late phase of the inflammation. (wikipedia.org)
  • At the beginning, there is a binding of collectin to PAMPs or DAMPs. (wikipedia.org)
  • The roles of these three collectins remain largely unknown. (jpt.com)
  • Hansen SW, Ohtani K, Roy N, Wakamiya N. The collectins CL-L1, CL-K1 and CL-P1, and their roles in complement and innate immunity. (medlineplus.gov)
  • In Nov 2014, I moved to King's College London and worked as a research associate in the lab of Prof. Wuding Zhou and Steven Sacks, where I studied the roles of complement particularly C5a and collectin 11 in immune regulation and disease. (ncl.ac.uk)
  • Collectins have effect on microorganism survival. (wikipedia.org)
  • When introduced into dermis or bleomycin-injured lungs of mice, collectins MBL and SP-D were endocytosed and routed for lysosomal degradation by uPARAP-positive fibroblasts. (regionh.dk)