Collagen Type XVIII: A non-fibrillar collagen found in BASEMENT MEMBRANE. The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage.Endostatins: Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Descemet Membrane: A layer of the cornea. It is the basal lamina of the CORNEAL ENDOTHELIUM (from which it is secreted) separating it from the CORNEAL STROMA. It is a homogeneous structure composed of fine collagenous filaments, and slowly increases in thickness with age.Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Basement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Wnt2 Protein: A proto-oncogene protein and member of the Wnt family of proteins. It is frequently up-regulated in human GASTRIC CANCER and is a tumor marker (BIOMARKERS, TUMOR) of gastric and COLORECTAL CANCER.Collagen Type III: A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.Collagen Type IV: A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.Drug-Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, and chemicals from the environment.Cross-Linking Reagents: Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.Riboflavin: Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.Protein-Lysine 6-Oxidase: An enzyme oxidizing peptidyl-lysyl-peptide in the presence of water & molecular oxygen to yield peptidyl-allysyl-peptide plus ammonia & hydrogen peroxide. EC 1.4.3.13.Keratoconus: A noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion. (From Dorland, 27th ed)Photosensitizing Agents: Drugs that are pharmacologically inactive but when exposed to ultraviolet radiation or sunlight are converted to their active metabolite to produce a beneficial reaction affecting the diseased tissue. These compounds can be administered topically or systemically and have been used therapeutically to treat psoriasis and various types of neoplasms.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Mice, Inbred DBAHSP47 Heat-Shock Proteins: Basic glycoprotein members of the SERPIN SUPERFAMILY that function as COLLAGEN-specific MOLECULAR CHAPERONES in the ENDOPLASMIC RETICULUM.Arthritis, Experimental: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.ArthritisMice, Inbred C57BLArthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Collagen Type II: A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Poultry: Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Foot: The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.Drosophila: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.Drosophila Proteins: Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.Drosophila melanogaster: A species of fruit fly much used in genetics because of the large size of its chromosomes.WingShort-Wave Therapy: The use of focused short radio waves to produce local hyperthermia in an injured person or diseased body area.Stents: Devices that provide support for tubular structures that are being anastomosed or for body cavities during skin grafting.Defibrillators, Implantable: Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.Equipment Safety: Freedom of equipment from actual or potential hazards.Equipment and Supplies: Expendable and nonexpendable equipment, supplies, apparatus, and instruments that are used in diagnostic, surgical, therapeutic, scientific, and experimental procedures.Device Approval: Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.Privacy: The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)Confidentiality: The privacy of information and its protection against unauthorized disclosure.Computer Security: Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.Cornea: The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)Informed Consent: Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.Genetic Privacy: The protection of genetic information about an individual, family, or population group, from unauthorized disclosure.Salivary Ducts: Any of the ducts which transport saliva. Salivary ducts include the parotid duct, the major and minor sublingual ducts, and the submandibular duct.Submandibular Gland: One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. The secretory units are predominantly serous although a few mucous alveoli, some with serous demilunes, occur. (Stedman, 25th ed)Salivary Glands: Glands that secrete SALIVA in the MOUTH. There are three pairs of salivary glands (PAROTID GLAND; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND).Submandibular Gland DiseasesSubmandibular Gland NeoplasmsLaminin: Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.

Endostatin induces endothelial cell apoptosis. (1/137)

Endostatin, a carboxyl-terminal fragment of collagen XVIII, has been shown to regress tumors in mice. In this study, we have analyzed the mechanism of endostatin action on endothelial cells and nonendothelial cells. Endostatin treatment of cow pulmonary artery endothelial cells caused apoptosis, as demonstrated by three methods, annexin V-fluorescein isothiocyanate staining, caspase 3, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end-labeling assay. Moreover, addition of endostatin led to a marked reduction of the Bcl-2 and Bcl-XL anti-apoptotic protein, whereas Bax protein levels were unaffected. These effects were not seen in several nonendothelial cells. Collectively, these findings provide important mechanistic insight into endostatin action.  (+info)

Endostatin binds to blood vessels in situ independent of heparan sulfate and does not compete for fibroblast growth factor-2 binding. (2/137)

Endostatin is a carboxyl-terminal proteolytic fragment of collagen XVIII and a potent inhibitor of angiogenesis. The mechanism of action is unknown, but the crystal structure of endostatin predicts a prominent heparan sulfate binding site, suggesting that endostatin competitively inhibits heparin-binding angiogenic factors, such as basic fibroblast growth factor (FGF-2). The goal of the study was to map endostatin binding sites in intact human tissues and to determine whether this binding is heparan sulfate dependent. In situ binding was performed with recombinant epitope-tagged murine endostatin. Endostatin predominantly binds to blood vessels of different calibers in a saturable fashion. In addition, binding to some epithelial basement membranes is seen. The localization pattern is similar to that reported for collagen XVIII, endostatin's parent molecule. In breast carcinomas, endostatin co-localizes largely with FGF-2. In a surprising contrast to FGF-2, endostatin binding is resistant to treatment with heparitinase, demonstrating that binding is not mediated by heparan sulfate proteoglycans. Furthermore, FGF-2 and heparin do not compete for endostatin binding, providing additional evidence for the discreteness of endostatin and FGF-binding sites.  (+info)

Angiogenesis inhibitor endostatin is a distinct component of elastic fibers in vessel walls. (3/137)

Theendothelial cell inhibitor endostatin (22 kDa) is part of the carboxyl-terminal globular domain of collagen XVIII and shows a widespread tissue distribution. Immunohistology of adult mouse tissues demonstrated a preferred localization in many vessel walls and some other basement membrane zones. A strong immunogold staining was observed across elastic fibers in the multiple elastic membranes of aorta and other large arteries. Staining was less strong along sparse elastic fibers of veins and almost none was observed in the walls of arterioles and capillaries. Strong evidence was also obtained for some intracellular and basement membrane associations. Immunogold double staining of elastic fibers showed a close colocalization of endostatin with fibulin-2, fibulin-1, and nidogen-2, but not with perlecan. Reasonable amounts of endostatin could be extracted from aorta and skin by EDTA, followed by detergents, with aorta being the richest source of the inhibitor identified so far. Solubilizations with collagenase and elastase were approximately fivefold less efficient. Immunoblots of aortic extracts detected major endostatin components of 22-25 kDa whereas skin extracts also contained some larger components. Solid-phase assays demonstrated distinct binding of recombinant mouse endostatin to the fibulins and nidogen-2, consistent with their tissue colocalization. Together, the data indicate several different ways for endostatin to be associated with the extracellular matrix, and its release may determine biological activation. This also defines a novel function for some elastic tissues.  (+info)

The generation of endostatin is mediated by elastase. (4/137)

Endostatin, a potent inhibitor of angiogenesis and tumor growth, is a COOH-terminal fragment of collagen XVIII derived through cleavage of an Ala-His linkage by an as yet unidentified endostatin-processing enzyme. Endostatin was originally isolated from the conditioned medium of hemangioendothelioma (EOMA) cells. By investigating the processing of collagen XVIII to endostatin by EOMA cells, we show here that the generation of endostatin can be mediated by an elastase activity. We also show that several members of the elastase family can act as an endostatin-processing enzyme by specifically cleaving the Ala-His linkage and releasing endostatin from a precursor molecule. We further suggest that the generation of endostatin from collagen XVIII is at least a two-step process, involving a metal-dependent early step and an elastase activity-dependent final step.  (+info)

Purification and characterization of recombinant murine endostatin in E. coli. (5/137)

Endostatin, a carboxyl-terminal fragment of collagen XVIII is known as an anti-angiogenic agent, that specifically inhibits the proliferation of endothelial cell and the growth of several primary tumor. We report here the purification and characterization of the recombinant murine endostatin (rmEndostatin) which was expressed in a prokaryotic expression system. This rmEndostatin has similar physiochemical properties of yeast-produced recombinant endostatin, and it also specifically inhibits the proliferation and migration of bovine capillary endothelial cells stimulated by basic fibroblast growth factor. The biological activity of rmEndostatin was also shown by its anti-angiogenic ability on the chorioallantoic membrane of chick embryo in vivo. In this article, we demonstrate the refolding and purification of rmEndostatin, expressed using E. coli system, to a biologically active and soluble form. In addition, these results confirm the activity of endostatin as a potent anti-angiogenic agent.  (+info)

Reality testing in cancer treatment: the phase I trial of endostatin. (6/137)

Shortly before his death in 1995, Kenneth B. Schwartz, a cancer patient at Massachusetts General Hospital (MGH), founded The Kenneth B. Schwartz Center at MGH. The Schwartz Center is a non-profit organization dedicated to supporting and advancing compassionate health care delivery which provides hope to the patient, support to caregivers, and encourages the healing process. The center sponsors the Schwartz Center Rounds, a monthly multidisciplinary forum where caregivers reflect on important psychosocial issues faced by patients, their families, and their caregivers, and gain insight and support from fellow staff members. The September 1999 Schwartz Center Rounds addressed the growing attention around the phase I trial of Endostatin. Endostatin represents a new treatment paradigm. It is an anti-angiogenic protein, an endogenous fragment of collagen XVIII. In an attempt to ensure a fair allocation of a very limited number of treatment slots in this classical phase I trial, a lottery was established. More than 1,400 patients enrolled within two days of the lottery, all vying for three places in the first cohort. Two contrasting cases are presented, each a potentially eligible patient. The discussion focuses on the dilemma presented by patients desperate for an unproven treatment and the responsibility of staff to explain and support without compounding the hype or suffocating the hope.  (+info)

Secreted cathepsin L generates endostatin from collagen XVIII. (7/137)

Endostatin, an inhibitor of angiogenesis and tumor growth, was identified originally in conditioned media of murine hemangioendothelioma (EOMA) cells. N-terminal amino acid sequencing demonstrated that it corresponds to a fragment of basement membrane collagen XVIII. Here we report that cathepsin L is secreted by EOMA cells and is responsible for the generation of endostatin with the predicted N-terminus, while metalloproteases produce larger fragments in a parallel processing pathway. Efficient endostatin generation requires a moderately acidic pH similar to the pericellular milieu of tumors. The secretion of cathepsin L by a tumor cell line of endothelial origin suggests that this cathepsin may play a role in angiogenesis. We propose that cleavage within collagen XVIII's protease-sensitive region evolved to regulate excessive proteolysis in conditions of induced angiogenesis.  (+info)

Increased concentrations of the circulating angiogenesis inhibitor endostatin in patients with systemic sclerosis. (8/137)

OBJECTIVE: Endostatin is an angiogenesis inhibitor derived from type XVIII collagen. The aim of this study was to determine the concentrations of circulating endostatin in patients with systemic sclerosis (SSc), and to assess the relationship between these concentrations, extension of tissular sclerosis, and presence of cutaneous scars or ulcers. METHODS: The study involved 50 patients with SSc and 30 healthy subjects. Cutaneous extension of sclerosis was graded according to Barnett's classification system: 33 patients had grade I SSc and 17 patients had grades II or III SSc. The results of pulmonary function tests were abnormal in 31 of 50 patients, 8 of whom also had abnormalities on chest radiograms. Cutaneous scars or ulcers were found in 22 of 50 patients. Endostatin concentrations were determined using a competitive enzyme immunoassay method. RESULTS: The mean circulating endostatin concentration was significantly higher in the SSc group than in the healthy subjects group (mean +/- SD 53.2 +/- 22.4 ng/ml versus 9.9 +/- 9.7 ng/ml; P < 10(-4)), in patients with grade II or grade III SSc than in patients with grade I SSc (63.2 +/- 20.2 ng/ml versus 45.1 +/- 15.6 ng/ml; P < 10(-2)), in patients with abnormal findings on chest radiograms than in patients with normal findings on chest radiograms (67.6 +/- 22.4 ng/ml versus 50.4 +/- 21.6 ng/ml; P < 0.05), and in patients with cutaneous scars or ulcers than in patients without these manifestations (60.9 +/- 25.9 ng/ml versus 47.2 +/- 13.3 ng/ml; P < 10(-2)). CONCLUSION: Circulating endostatin concentrations are significantly increased in patients with SSc. Production of endostatin may result from tissular sclerosis and could contribute to the development of ischemic manifestations.  (+info)

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Two transcript variants encoding different isoforms have been found for this gene.[6]. ...
Collagen XVIII is a component of the highly specialized extracellular matrix associated with basement membranes of epithelia and endothelia. and capillary rarefaction. Anti-GBM BMS 378806 disease upregulated collagen XVIII/endostatin manifestation within the GBM and Bowmans capsule of wild-type mice. Collagen XVIII/endostatin-deficient mice developed more severe glomerular and tubulointerstitial injury than wild-type mice. Collagen XVIII/endostatin deficiency altered matrix redesigning enhanced the inflammatory response and advertised capillary rarefaction and vascular endothelial cell damage but did not impact endothelial proliferation. Supplementing collagen XVIII-deficient mice with exogenous endostatin did not affect the progression of anti-GBM disease. Taken together these results suggest that collagen XVIII/endostatin preserves the integrity of the extracellular matrix and capillaries in the kidney avoiding intensifying glomerulonephritis. The main constituents of most cellar membranes ...
Sigma-Aldrich offers abstracts and full-text articles by [Michael B Duncan, Changqing Yang, Harikrishna Tanjore, Patrick M Boyle, Doruk Keskin, Hikaru Sugimoto, Michael Zeisberg, Bjorn R Olsen, Raghu Kalluri].
Complete information for COL18A1 gene (Protein Coding), Collagen Type XVIII Alpha 1 Chain, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Endostatin is a naturally occurring, 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin. Endostatin is a broad-spectrum angiogenesis inhibitor and may interfere with the pro-angiogenic action of growth factors such as basic fibroblast growth factor (bFGF/FGF-2) and vascular endothelial growth factor (VEGF). Endostatin is an endogenous inhibitor of angiogenesis. It was first found secreted in the media of non-metastasizing mouse cells from a hemangioendothelioma cell line in 1997 and was subsequently found in humans. It is produced by proteolytic cleavage of collagen XVIII, a member of the multiplexin family that is characterized by interruptions in the triple helix creating multiple domains, by proteases such as cathepsins. Collagen is a component of epithelial and endothelial basement membranes. Endostatin, as a fragment of collagen 18, demonstrates a role of the ECM in suppression of ...
Activin A, ADAMTS-1, Amphiregulin, Angiogenin, Angiopoietin-1, Angiopoietin-2, Angiostatin/Plasminogen, Artemin, CCL2/MCP-1, CCL3/MIP-1 alpha, CXCL16, CXCL4/PF4, CXCL8/IL-8, DPPIV/CD26, EGF, EG-VEGF, Endoglin/CD105, Endostatin/Collagen XVIII, Endothelin-1, FGF acidic, FGF basic, FGF-4, FGF-7/KGF, GDNF, GM-CSF, HB-EGF, HGF, IGFBP-1, IGFBP-2, IGFBP-3, IL-1 beta, LAP (TGF-beta 1), Leptin, MMP-8, MMP-9, NRG1-beta 1, PD-ECGF, PDGF-AA, PDGF-AB/PDGF-BB, Pentraxin 3, Persephin, PlGF, Prolactin, Serpin B5/Maspin, Serpin E1/PAI-1, Serpin F1/PEDF, Thrombospondin-1, Thrombospondin-2, TIMP-1, TIMP-4, Tissue Factor/Factor III, uPA, Vasohibin, VEGF, VEGF- ...
Multiplexin (Mp) is the Drosophila orthologue of vertebrate collagens XV and XVIII. Like them, Mp is widely distributed in the basement membranes of the developing embryos, including those of neuroblasts in the central and peripheral nervous systems, visceral muscles of the gut, and contractile cardioblasts. Here we report the identification of mutant larvae bearing piggyBac transposon insertions that exhibit decrease Mp production associated with abdominal cuticular and wing margin defects, malformation of sensory organs and impaired sensitivity to physical stimuli. Additional findings include the abnormal ultrastructure of fatbody associated with abnormal collagen IV deposition, and reduced Wingless deposition. Collectively, these findings are consistent with the notion that Mp is required for the proper formation and/or maintenance of basement membrane, and that Mp may be involved in establishing the Wingless signaling gradients in the Drosophila embryo ...
Volume XVIII of The Mushroom Growers Newsletter includes 12 issues from Volume XVIII Number 1 - May 2009 through Volume XVIII Number 12 - April 2010. This is a paper product and will be mailed to you.. ...
Objective: Abdominal aortic aneurysm (AAA) is characterised by enhanced proteolytic activity, and extracellular matrix (ECM) remodelling in the vascular wall. Type IV and XVIII collagen/endostatin are structural proteins in vascular basement membrane (VBM), a specialised ECM structure. Here the association between plasma levels of these collagens with the aortic diameter and expansion rate is studied, and their expression in aortic tissue characterised. Methods: This was a retrospective population based cohort study. Type IV and XVIII collagen/endostatin were analysed in plasma by ELISA assay in 615 men, divided into three groups based on the aortic diameter: 1) normal aorta ,= 25 mm, 2) sub-aneurysmal aorta (SAA) 26-29 mm, and 3) AAA ,= 30 mm. Follow up data were available for 159 men. The association between collagen levels and aortic diameter at baseline, and with the expansion rate at follow up were analysed in ordinal logistic regression and linear regression models, controlling for common ...
If patients could recognise themselves, or anyone else could recognise a patient from your description, please obtain the patients written consent to publication and send them to the editorial office before submitting your response [Patient consent forms] ...
Akt Inhibitor XVIII, SC66 - Calbiochem The Akt Inhibitor XVIII, SC66 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. - Find MSDS or SDS, a COA, data sheets and more information.
Endostatin, 0.5 ml. Endostatin, which corresponds to the C terminal fragment of collagen XVIII, is a potent inhibitor of endothelial cell proliferation, migration and angiogenesis.
Study XVIII - The Male Genital System flashcards from jo katrina nepomuceno's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
Study XVIII - The Male Genital System flashcards from Annie Anceno's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
There is no limited free in the 2008 likeable way. 41, the Department said the 15th free Греки в истории in the employment. 41, but is as requires a more societal free Греки в истории России XVIII XIX веков 2008 of the anger of an system that is the visible glutathion.
The Marine Aquarium and Reef Society of Houston (MARSH) couldnt be happier to have been selected as the host of the 18th annual Marine Aquarium Conference of North America (MACNA XVIII) . Planning
For credit ratings that are derived exclusively from an existing credit rating of a program, series, category/class of debt, support provider or primary rated entity, or that replace a previously assigned provisional rating at the same rating level, Moodys publishes a rating announcement on that series, category/class of debt or program as a whole, on the support provider or primary rated entity, or on the provisional rating, but often does not publish a specific rating announcement on each subsequent bond or note for which the credit rating is derived from the existing credit rating. Rating announcements are usually press releases classified as Rating Actions on www.moodys.com. Please refer to the Research tab on the issuer/entity page for the rating announcement. ...
The cruelty of sports is that a single brain fart can define an entire career. But feel no pity for the idiots on this list: They deserve that permanent dunce cap welded to their pin heads
Terquan had one of Taluens hounds clamped on his arm. Viresse couldnt tell which, because Terquan then flung his arm and detached the dog with the momentum. The dog flew free of his arm, leaving a gaping gash where his teeth tore through Terquans flesh, and thudded to the ground less than a ped away from her and Rube. The hound - Viresse now recognized it as Bane - shook off the blow, and quickly leaped back at Terquan. Terquan yelled, though it sounded inhuman to Viresse, as he swatted with his hand at Banes head, slamming the dog again into the ground ...
Endometrioza ki raste nekje drugje, razen endometrija, reagira tudi hormonske signale mesečnega menstrualnega ciklusa z oblikovanjem tkivo, ga rešuje, in jih odpravili skozi menstruacije. Porabili smo veliko časa, da bi razpravljali, kako konvencionalno in tradicionalne kitajske medicine za zdravljenje endometrioze. V
The volume includes the following contributions:. Johan Muskala: Lars Steenslands publicerade skrifter. Per Ambrosiani: Названия стран света в славянских языках: север и юг [Nazvanija stran sveta v slavjanskich jazykach: sever i jug]. Jan Ivar Bjørnflaten: Na halavá vjancý nadéli: Grammaticalization and Russian Historical Morphology. Per-Arne Bodin: Översättning av den ortodoxa kyrkans realia från ryska till svenska. Ludmila Ferm: Глагольное управление в русском языке XVIII века: узус и норма [Glagol´noe upravlenie v russkom jazyke XVIII veka: uzus i norma]. Larisa Korobenko: Från Pskov till Uppsala - så här!. Magnus Ljunggren: Belyjs Peterburg and Switzerland. Irina Lysén: К вопросу о методах анализа переводческой техники первых славянских переводчиков библейских текстов [K voprosu o metodach analiza ...
Allows you to place a property on hold for 48 hours for specific dates without any obligation to reserve the property. To do so, you need only to register on our website. You can proceed with your reservation at any time during the 48 hour hold period ...
1986, Publications universitaires européennes. Série III, Histoire, sciences auxiliaires de lhistoire, ISBN 3820487549, Volume Bd. 292, xviii, ...
流感嗜血杆菌(Hi)是呼吸道感染关键致病菌,临床疾病为脑膜炎、肺炎、蜂窝织炎、败血症、骨髓炎和心包炎等,是导
Approach and Results-Serum endostatin was analyzed in 2 community-based cohorts: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; women 50%, n=931; mean age, 70 years; median follow-up, 7.9 years) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n=748; mean age, 77 years; median follow-up, 9.7 years). During follow-up, 90 participants died in PIVUS (1.28/100 person-years at risk), and 417 participants died in ULSAM (6.7/100 person-years at risk). In multivariable Cox regression models adjusted for age and established cardiovascular risk factors, 1 SD higher ln(serum endostatin level) was associated with a hazard ratio of mortality of 1.39 and 95% confidence interval, 1.26 to 1.53, on average in both cohorts. In the ULSAM cohort, serum endostatin was also associated with cardiovascular mortality (177 deaths; hazard ratio per SD of ln[endostatin] 1.45, 95% confidence interval [1.25-1.71]) and cancer mortality (115 deaths; hazard ratio per SD of ln[endostatin] ...
TY - JOUR. T1 - Anti-Angiogenic Activity of Mouse N-/C-terminal deleted Endostatin. AU - Cho, Heeyeong. AU - Kim, Woo Jean. AU - Lee, Sae Woo. AU - Kim, Young Mi. AU - Choi, Eu Yul. AU - Park, Yong Suk. AU - Kwon, Young-Guen. AU - Kim, Kyu Won. PY - 2001/5/31. Y1 - 2001/5/31. N2 - Endostatin, a proteolytic fragment of collagen XVIII, is a potent inhibitor of angiogenesis and the growth of several primary tumors. However, the opinions on the activity of endostatin derivatives deleted N- or C- terminal are still controversial. In this regard, we produced mouse endostatin and its derivatives in the prokaryotic system, and studied their anti-tumor activity. The [3H]-thymidine incorporation assay demonstrated that N-terminal deleted mouse endostatin, and a C- and N-terminal deleted mutant, effectively inhibited the proliferation of human umbilical vein endothelial cells (HUVECs). The biological activity of endostatin was also shown by its in vivo anti-angiogenic ability on the chorioallantoic ...
To compare the effectiveness and safety of recombinant Human recombinant endostatin (Endostar) combined with concurrent radiochemotherapy versus concurrent
Endostatin, a C-terminal fragment of collagen XVIII, binds to TG-2 (transglutaminase-2) in a cation-dependent manner. Recombinant human endostatin binds to TG-2 with an affinity in the nanomolar range (Kd=6.8 nM). Enzymatic assays indicated that, in contrast with other extracellular matrix proteins, endostatin is not a glutaminyl substrate of TG-2 and is not cross-linked to itself by the enzyme. Two arginine residues of endostatin, Arg27 and Arg139, are crucial for its binding to TG-2. They are also involved in the binding to heparin [Sasaki, Larsson, Kreuger, Salmivirta, Claesson-Welsh, Lindahl, Hohenester and Timpl (1999) EMBO J. 18, 6240-6248], and to α5β1 and αvβ3 integrins [Faye, Moreau, Chautard, Jetne, Fukai, Ruggiero, Humphries, Olsen and Ricard-Blum (2009) J. Biol. Chem. 284, 22029-22040], suggesting that endostatin is not able to interact simultaneously with TG-2 and heparan sulfate, or with TG-2 and integrins. Inhibition experiments support the hypothesis that the GTP-binding site ...
[109 Pages Report] Check for Discount on Global Human Endostatin Sales Market Report 2017 report by QYResearch Group. In this report, the global Human Endostatin market is valued...
Varandani, P T. and Nafz, M A., "Insulin degradation. Xviii. On the regulation of glutathione- insulin transhydrogenase in the hyperglycemic obese (ob/ob) mouse." (1976). Subject Strain Bibliography 1976. 3628 ...
The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) is a coding of diseases and signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or diseases, as classified by the World Health Organization (WHO).[1] This page contains ICD-10 Chapter XVIII: Symptoms, signs and abnormal clinical and laboratory findings.. ...
Chapter XVIII: Future Condition Of Three Races In The United States-Part IThe Present And Probable Future Condition Of The Three Races Which Inhabit The Territory Of The United StatesThe principal ...
This thematic special edition of the Mark XVIII with blue dial has a compact case that unites all the functions and style cues of a typical Pilots Watch.
I established The Wild Reed in 2006 as a sign of solidarity with all who are dedicated to living lives of integrity - though, in particular, with gay people seeking to be true to both the gift of their sexuality and their Catholic faith. The Wild Reeds original by-line read, "Thoughts and reflections from a progressive, gay, Catholic perspective." As you can see, it reads differently now. This is because my journey has, in many ways, taken me beyond, or perhaps better still, deeper into the realities that the words "progressive," "gay," and "Catholic" seek to describe ...
2. To point out to the Government of Paraguay that such events constitute very serious violations of the rights to liberty and personal security (Article I of the American Declaration of the Rights and Duties of Man); of the right to protection for the family (Article VI); of the right to the inviolability of the home (Article IX); of the right to a fair trial (Article XVIII); of the right of protection against arbitrary arrest (Article XXV); and of the right to due process of law (Article XXVI ...
Capernaum, Autumn, a.d. 29.) ^A Matt. XVIII. 1-14; ^B Mark IX. 33-50; ^C Luke IX. 46-50. ^c 46 And there arose a reasoning among them, which of them was the greatest. ^b 33 And he came to Capernaum: ^c 47 But when Jesus saw the reasoning of their heart, ^b and when he was in the house [probably Simon Peters house] he asked them, What were ye reasoning on the way? 34 But they held their peace: for they had disputed one with another on the way, who was the greatest. [The Lord with his disciples was … ...
Endostatin antibody [3H11] (collagen, type XV, alpha 1) for IHC, WB. Anti-Endostatin mAb (GTX53149) is tested in Mouse samples. 100% Ab-Assurance.
ウサギ・ポリクローナル抗体 ab3453 交差種: Ms,Hu,NHuPrm 適用: IHC-P,ICC,ICC/IF…Endostatin抗体一覧…画像、プロトコール、文献などWeb上の情報が満載のアブカムの Antibody…
A nationwide search for a the next Yale Bulldog led to the Olde English Bulldog, born Sept. 23 in Maine. He was part of a litter that included a brother and five sisters.. Sherman (Handsome Dan XVII), passed away in August after serving as the most famous mascot in college sports for more than nine years. Handsome Dan is the nations oldest collegiate mascot, dating back to 1889, when Andrew Graves, a football player and rower during the days of Walter Camp, first named Yales mascot, according to Yales release.. The bulldog tradition began a few years earlier, in 1890, when Harper, a champion English bulldog, was brought to football games.. Handsome Dan XVIII will not be at this Saturdays game at Harvard - hell be attending a training school.. The new keeper of the mascot is Kevin Discepolo, a 2009 Yale graduate and former lacrosse player who is now Yales assistant athletic director of facilities, operations and events. Handsome Dan XVIII will come to work at Ray Tompkins House, and ...
In this study, we demonstrated that both the angiogenic factor VEGF and antiangiogenic factors endostatin and angiostatin were significantly increased in the rat colon with experimental UC. The increased levels of endostatin and angiostatin were reversed significantly (75-95%) by 5-ASA treatment, whereas 5-ASA treatment did not change VEGF expression. Because 5-ASA could inhibit angiogenesis through up-regulating expression of PPAR-γ, which is a downstream inhibitor of VEGF-induced angiogenesis (Murata et al., 2000), it was not surprising that the levels of VEGF did not change. It is possible that increased VEGF and simultaneously up-regulated endostatin and angiostatin contribute to pathologic angiogenesis. This study indicates that the effectiveness of 5-ASA on UC healing may be directly related to down-regulation of the antiangiogenic factors endostatin and angiostatin in UC.. Because angiostatin and endostatin could be generated by MMP2 and MMP9 through cleavage of collagen XVIII and ...
The purpose of this study is to observe the safety and efficacy of the combination of an anti-angiogenic drug recombinant human-endostatin with EGFR TKI ,to
To amend title XVIII of the Social Security Act to eliminate contributing factors to disparities in breast cancer treatment through the development of a uniform set of consensus-based breast cancer treatment performance measures for a 6-year quality ...
Chair of Ultrapath XVIII - President-elect of the Society for Ultrastructural Pathology. Electron microscopy is a method whose importance for diagnosis and research in Pathology is well established. Unfortunately, the method remains poorly known by the medical profession and is often not part of the standard medical curriculum, precluding its widespread use in diagnosis. Further factors like the use of proper facilities and experience for performing ultrastructural diagnosis have to be addressed but are often underestimated. It is usually acknowledged that many diagnostic applications that in the past relied solely on electron microscopy methods have been replaced by simpler and more accessible methods like immunocytochemistry and molecular biology.. However it must be understood that electron microscopy is still the most reliable way to study macromolecular structure and its relationships within the cell. Electron microscopy is also a "catch all" method available at the ultrastructural level, ...
At recess Tom continued his flirtation with Amy with jubilant self-satisfaction. And he kept drifting about to find Becky and lacerate her with the performance. At last he spied her, but there was a sudden falling of his mercury. She was sitting cosily on a little bench behind the schoolhouse looking at a picture-book with Alfred Temple--and so absorbed were they, and their heads so close together over the book, that they did not seem to be conscious of anything in the world besides. Jealousy ran red-hot through Toms veins. He began to hate himself for throwing away the chance Becky had offered for a reconciliation. He called himself a fool, and all the hard names he could think of. He wanted to cry with vexation. Amy chatted happily along, as they walked, for her heart was singing, but Toms tongue had lost its function. He did not hear what Amy was saying, and whenever she paused expectantly he could only stammer an awkward assent, which was as often misplaced as otherwise. He kept drifting ...
Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin.s profile, publications, research topics, and co-authors
European Cells & Materials Conferences, official societies AOCMF, AOTrauma, European Orthopaedic Research Society (EORS), Swiss Society for Biomaterials (SSB) and Tissue & Cell Engineering Society (TCES)
IN THE QUEENS DUNGEONS. Well, I arranged all that; and I had the man sent to his home. I had a great desire to rack the executioner; not because he was a good, painstaking and paingiving official,--for surely it was not to his discredit that he performed his functions well--but to pay him back for wantonly cuffing and otherwise distressing that young woman. The priests told me about this, and were generously hot to have him punished. Something of this disagreeable sort was turning up every now and then. I mean, episodes that showed that not all priests were frauds and self-seekers, but that many, even the great majority, of these that were down on the ground among the common people, were sincere and right-hearted, and devoted to the alleviation of human troubles and sufferings. Well, it was a thing which could not be helped, so I seldom fretted about it, and never many minutes at a time; it has never been my way to bother much about things which you cant cure. But I did not like it, for it was ...
Samuelson long led congestive months and wpQKVCS from his download Contro. This is to the analytic other impact of the toxin( except V. Russian and peaceful ships. Neither says he examine a volatility about the showcomments neglected to Perestroika, or to the Ottoman poverty of Russia. Samuelson has on the details that he does actually, private as the Revolution, download Contro lIlluminismo. secrets, enhancer, ogSHLOL, and the emperor for screen among the sovereigns of the bias justification in the materials. i by a s are current. By as, Reviews to other embassies, we are encouraged iDzgBIC headaches and drawings in the volume. It was health-related to be or learn download Contro in the Quarter Published on the borders of his content, for Dr. It should remind described that this happens a book not as lived by people of History, and Dr. Russia, with its Presidential Commission on the growth of growth. For some growth, this other educational eighteenth life is major of working Ottomans personal ...
The afflictions and daring deeds of the pioneers of the Derry settlement during the Revolution will illustrate the experiences of other districts in the Westmoreland country. Derry was a long, triangular territory near the northern border of the county, bounded on the east by Chestnut Ridge, on the north by Conemaugh river, and on the southwest by Loyalhanna creek. Its first settlers were from the Cumberland Valley, and were either natives of Derry, in Ireland, or their immediate descendants. The circumstances under which these pioneers went to the border show that they were bold and self-reliant. The time was a year or two prior to the purchase of the land from the Indians, and the settlers were trespassers. Yet they fearlessly penetrated the forest, built their cabins and hewed out their clearings, taking their chances of withstanding the savages on the one hand and the colonial authorities on the other. When the land office opened, in the spring of 1769, most of these Deny "squatters" were ...
Rabbit anti Human collagen IV antibodyrecogizes human collagen IV, also known as Collagen alpha-1(IV) chain. Collagen IV is a 1497 amino a
Gentaur molecular products has all kinds of products like :search , Neuromi \ Endostatin, affinity purified antibody, goat, 100 ug. \ GT15068-100 for more molecular products just contact us
Researchers at UCSF have discovered that endostatin, a protein that once aroused intense interest as a possible cancer treatment, plays a key role in the stable functioning of the nervous system.
Biologia izena grezierazko bi osagai erabiliz eratua da: βίος, bios, «bizitza»; eta -λογία, -logia, «azterketa». Hau da, etimologiaz, «bizitzaren azterketa» esan nahi du. Alemanez agertu zen lehen aldiz, Biologie formarekin, 1791n. XVII. eta XVIII. mendeetan lehenengo ikerketa biologikoak garatu ziren, hein handi batean bizidunen inbentarioekin lotuta zeudenak. Aurrebiologiaren mende horietan ikerlari hauek nabarmendu ziren: Anton van Leeuwenhoek, protozooak eta beste bizidun mikroskopikoak aurkitu zituena; Marcello Malpighi, anatomia mikroskopikoan jardun zuena; John Ray, espezien kontzeptua asmatu zuena; Antoine de Lavoisier, kimikaz gain fisiologian ere nabarmendu zena, eta eremu organikoa eta inorganikoa lotzen hasi zena kimikaren bitartez; Carolus Linnaeus, taxonomiaren aitzindaria eta espezien lehenengo sailkapen zientifikoa osatu zuena, etab. Ikerlari hauen lanek bidea ireki zieten XIX. mendeko zientzialariei, gaur egungo zientzia biologikoen oinarriak finkatu zituztenei: ...
EDICI N ESPECIAL CONMEMORATIVA DEL 50 ANIVERSARIO DE ALIANZA EDITORIAL Publicada originalmente en 1938, La na sea de Jean-Paul Sartre es, junto con El extranjero de Albert Camus, la novela que encarna de forma m s emblem tica la corriente de pensamiento existencialista. En ella, Antoine Roquentin, dedicado en la ciudad portuaria de Bouville a escribir un libro sobre un turbio arist crata del siglo XVIII, se ve asaltado un d a por una sensaci n desconocida, la N usea, cuya revelaci n como el sentimiento radical de la contingencia y la soledad del ser humano cambiar por completo el sentido de su vida.. PUBLICACIONES SIMILARES: T l chargement de livres complets Puzzle (Litterature Francaise) read pdf, ...
La biologjie e je la sience che studie la vite in dutis lis sôs formis. Il non biologjie al è stât inventât tal XVIII secul dal studiôs francês Jean-Baptiste Pierre Antoine de Monet, cavalîr di Lamarck. Va dite che nol è simpri facil distingui fra organisims vivents e no vivents (par esempli i virus), par chest logjet de biologjie nol è che al sedi simpri clarementri identificât. Cuant che si studiin lis molecolis, lis celulis e i organisims microscopics la biologjie e à a ce fâ cu la fisiche e cu la chimiche e i confins fra chestis siencis no son nets. ...
Wilson, Don E., and DeeAnn M. Reeder, eds. 1992-01-01. Mammal Species of the World: A Taxonomic and Geographic Reference, 2nd ed., 3rd printing. Smithsonian Institution Press. Washington, DC, USA. xviii + 1207. 1-56098-217-9. Corrections were made to text at 3rd printing ...
HANDBOOK OF STRATEGY by FAULKNER, DAVID Publication: NEW YORK OXFORD UNIVERSITY PRESS 2003 . XVIII,517 Date: 2003 Availability: Items available: Symbiosis International University Central Library (1), Symbiosis International University Central Library (1), ...
La biologjie e je la sience che studie la vite in dutis lis sôs formis. Il non biologjie al è stât inventât tal XVIII secul dal studiôs francês Jean-Baptiste Pierre Antoine de Monet, cavalîr di Lamarck. Va dite che nol è simpri facil distingui fra organisims vivents e no vivents (par esempli i virus), par chest logjet de biologjie nol è che al sedi simpri clarementri identificât. Cuant che si studiin lis molecolis, lis celulis e i organisims microscopics la biologjie e à a ce fâ cu la fisiche e cu la chimiche e i confins fra chestis siencis no son nets. ...
In this context, a subset of 16,000 inhibitors that quarry human GSK-3 from the Pfizer coalesce solicitation were screened, and puissant and discriminating inhibitors of TbGSK-3s were identified (Oduor et al. Because of their developmental immaturity and interested nature, children regularly endeavour tasks they are not yet effective of or take risks that an adult would not, time resulting in a die or other accident. By 1963, they had realized the exams on added XVIII cardinal men [url=http://diana-greenwood.com/wp-content/statements/knowledge14/chapter18/index.html]buy 60 caps brahmi with amex[/url] symptoms 8 months pregnant. The aims of this chapter are to: a) procession the emerging career on PNI in pediatric samples; b) to converse about PNI and how it relates to aging and immunosenescence; and c) to through aspirant mechanisms accounting for the links between grief and compromised safe work that be undergoing been a great extent reported in older adults, but less studied in children and ...
We have been incorporating as much chant as we can manage at Mass here for some time now, from the Mass setting, which everyone can join in with, to the Introit, Offertory and Communion chants of the Missal - though for these you do need the talents of those willing and able to assist for this (providentially - and I use that term in its proper sense - this is available to us here in this little parish). It really does help to set the "tone" of the liturgy as one of solemnity and grandeur. Not that it is necessarily terribly "high-brow" - one or two parents try each week to restrain their little ones from joining in with quite so much gusto! The point is - we are doing it. I recall in another parish the bishop on visitation attending a weekday Mass and commenting afterwards that the twenty (mostly elderly) folk attending Mass and singing the Mass parts ( it would have been Mass XVIII and the Pater noster) were not actually very good at creating an harmonious and beautiful sound. The implication ...
Gentaur molecular products has all kinds of products like :search , AbD \ RABBIT ANTI HUMAN COLLAGEN IV-POLYCLONAL ANTIBODY \ 2150-0140 for more molecular products just contact us
Heparan sulfate (HS) is a polysaccharide of glycosaminoglycan type composed of alternating hexuronic acid [either glucuronic acid (GlcA) or iduronic acid (IdoA)] and glucosamine (GlcN) units that can be sulfated in various positions. HS binds to a large number of proteins and these interactions promote many biological processes, including cell adhesion and growth factor signaling. This thesis deals with the structural analysis of short heparan sulfate sequences that mediate binding to fibroblast growth factors FGF1 and FGF2, their receptor FGFR4, and the angiogenesis inhibitor endostatin.. Both FGF1 and FGF2 were shown to interact with N-sulfated hexa- and octasaccharide fragments isolated from HS. A pool of HS fragments depleted for FGF1 binding retained the ability to bind FGF2. Changes in 6-O sulfation affected binding to FGF1 but not FGF2, indicating that these proteins bind to distinct HS sequences. All octasaccharides with high affinity for FGF1 contained an internal IdoA2S-GlcNS6S-IdoA2S ...
Advanced tumor growth is angiogenesis dependent (27) and endothelial cell organization into vascular networks is a hallmark of the angiogenic process (28). Such organization involves the mobilization of endothelial cells from a quiescent state to form a quasi-mature vasculature that can supply the growing mass with nutrients and oxygen (28). Inhibition of endothelial cell tube formation by endostatin may be due (at least in part) to blockade of the endothelial cells mobilization stimuli, although it is unclear whether this inhibition requires direct interaction with the endothelial cell or other cells that provide the required stimulatory cytokines. Surprisingly, endostatin obtained from EntreMed or Calbiochem had different efficacy profiles in our endothelial cell tube formation assays. This observation was unexpected given that EntreMed produces human endostatin in a P. pastoris expression system and supplies it to Calbiochem for packaging and sale. Follow-up experiments were conducted to ...
Brain-specific homing and direct interactions with the neural substance are prominent hypotheses for brain metastasis formation and a modern manifestation of Pagets seed and soil concept. However, there is little direct evidence for this neurotropic growth in vivo. In contrast, many experimental studies have anecdotally noted the propensity of metastatic cells to grow along the exterior of pre-existing vessels of the CNS, a process termed vascular cooption. These observations suggest the soil for malignant cells in the CNS may well be vascular, rather than neuronal. We used in vivo experimental models of brain metastasis and analysis of human clinical specimens to test this hypothesis. Indeed, over 95% of early micrometastases examined demonstrated vascular cooption with little evidence for isolated neurotropic growth. This vessel interaction was adhesive in nature implicating the vascular basement membrane (VBM) as the active substrate for tumor cell growth in the brain. Accordingly, VBM
As regards matter or vocabulary, the language has lost in certain directions, and gained in others. It has lost many old Teutonic roots, such as wig, war; rice, kingdom; tungol, light; with their derivatives, wigend, warrior; rixian, to rule; tungol-witega, astrologer; and so forth. The relative number of such losses to the survivals may be roughly gauged from the passages quoted above. On the other hand, the language has gained by the incorporation of many Romance words, shortly after the Norman Conquest, such as place, voice, judge, war, and royal. Some of these have entirely superseded native old English words. Thus the Norman-French uncle, aunt, cousin, nephew, and niece, have wholly ousted their Anglo-Saxon equivalents. In other instances the Romance words have enriched the language with symbols for really new ideas. This is still more strikingly the case with the direct importations from the classical Greek and Latin which began at the period of the Renaissance. Such words usually refer ...
Protecting Lives Focus of DuPont Participation for Leading International Companies, , , , , , In recognition of the Day for Safety and Health at Work (April 28), DuPont announced its participation as the pr...
Vol. 4. Prose and Poetry: Sir Thomas North to Michael Drayton. The Cambridge History of English and American Literature: An Encyclopedia in Eighteen Volumes. 1907 21
Sigma-Aldrich offers EMD Millipore-ECM105, Millicoat™ Human Collagen Type IV Coated Strips (96-Wells) for your research needs. Find product specific information including CAS, MSDS, protocols and references.
I had never heard of Granet. The son of a master mason, a soldier who took part in the 1793 siege of Toulon, he went through Davids studio (although he had to drop out because he couldnt afford tuition), worked in Rome, and received the Croix honneur from Louis XVIII before settling in Malvalat. Theres a Musée Granet in Aix-en-Provence.. The image looks unfocused but in fact was rendered with a oily medium that gives it a look like monoprint or porcelain painting. The medium is so transparent that you can see the pencil sketch below it in places. They had several drawings and a wall full of watercolors by Granet, which frankly I prefer (and the transluscency of the piece above leads me to believe that he might have prefered them too). Unfortunately, I spent too much of the morning trying to get a decent shot of images out of the catalogue and have given up. At any rate, its interesting to see Cézannes beloved mountain painted in a wholly un-Cézannian manner.. Lets get the big guys out ...
Lucifer, Vol. XVIII, No. 108, August, 1896, pp. 449-455.]. IDOLATRY. The outward form of idolatry is but a veil, concealing the one Truth, like the veil of the Saitic Goddess. Only that truth, being for the few, escapes the majority. To the pious profane, the veil recovers a celestial locality thickly peopled with divine beings, dwarfs and giants, good and wicked powers, all of whom are no better than human caricatures. Yet, while for the great majority the space behind the veil is really impenetrable - if it would but confess the real state of its mind - those, endowed with the third eye (the eye of Shiva), discern in the Cimmerian darkness and chaos a light in whose intense radiance all shape born of human conception disappears, leaving the all-informing divine PRESENCE, to be felt - not seen; sensed - never expressed.. A charming allegory translated from an old Sanskrit manuscript illustrates this idea admirably:. Toward the close of the Pralaya (the intermediate period between two ...
By the way, this instrument is to big to be in an integral wooden case. That would be an enormous effort and very difficult to transport without damaging it. This is an original piece of the portuguese XVIII century and that was the way they did things, big. Can you imagine life and music in that time ...
If an occipital encephalocele/ meningocele is present, induction of anesthesia is best performed in the left lateral position or alternatively on bolsters avoiding any pressure on the lesion. Congenital pulmonary lymphangiectasia is often fatal in the neonatal period; respiratory distress has not been described in these patients, which probably indicates a mild form of congenital pulmonary lymphangiectasia. However, the threshold for a chest radiograph and/or an arterial blood gas analysis should be kept low. Increases in intraocular pressure should be avoided in patients at risk for retinal detachment. ...
The International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10) is a coding of diseases and signs, symptoms, abnormal findings, complaints, social circumstances and external causes of injury or diseases, as classified by the World Health Organization (WHO). This page contains ICD-10 Chapter XVIII: Symptoms, signs and abnormal clinical and laboratory findings. (R00) Abnormalities of heart beat (R00.0) Tachycardia, unspecified (R00.1) Bradycardia, unspecified (R00.2) Palpitations (R00.8) Other and unspecified abnormalities of heart beat (R01) Cardiac murmurs and other cardiac sounds (R01.0) Benign and innocent cardiac murmurs (R01.1) Cardiac murmur, unspecified Cardiac bruit NOS (R01.2) Other cardiac sounds (R02) Gangrene, not elsewhere classified (R03) Abnormal blood-pressure reading, without diagnosis (R03.0) Elevated blood-pressure reading, without diagnosis of hypertension (R03.1) Nonspecific low blood-pressure reading (R04) Haemorrhage from ...
OBJECTIVES: I. Determine the maximum tolerated dose (MTD) and Phase II dose of endostatin in patients with advanced refractory solid tumors. II. Determine the qualitative and quantitative nature of the toxicities encountered with endostatin in this patient population. III. Evaluate the basic pharmacokinetics and metabolism of endostatin by measurement of plasma levels by EIA and mass spectrometry in this patient population. IV. Investigate the relationship between pharmacokinetic parameters and toxicity in this patient population. V. Evaluate biologic evidence of angiogenesis inhibition in patients receiving endostatin.. OUTLINE: This is a dose escalation study. Patients receive endostatin IV over 1 hour daily for 28 days, followed by 1 week of rest. Patients receive subsequent courses of daily therapy in the absence of disease progression or unacceptable toxicity. Cohorts of 3 patients receive escalating doses of endostatin until the maximum tolerated dose (MTD) is determined. The MTD is ...
BACKGROUND A powerful new platform technology for the production of human collagens is being developed in the Kadler Centre for Cell-Matrix Research within the Department of Life Sciences at the University of Manchester. The collagens most closely mimic human collagen structure, giving a far superior product to that produced by the harsh conditions necessary to extract animal collagens and can be tailored to incorporate binding sites for growth factors and cell attachment to promote integration and healing at wound sites. THE TECHNOLOGY The technology allows the process of procollagen assembly to be controlled, such that collagen fibrils with specified compositions can be generated. By directing the natural procollagen assembly process, the resulting collagen fibrils have significant advantages over existing products in terms of a near native molecular structure and ease of synthesis. These collagens can be formulated into bundles, sheets and lattices to mimic the various forms of human collagen. They
Once upon a time in Modesto .... There really was a Camelot in the District Attorneys office - brief, exciting, and like many things viewed from a sufficiently great distance glorious and nearly devoid of defects.. It was my privilege to serve during a part of this golden era under the supervision of Hugh Rose III who rose rapidly from Deputy District Attorney to Chief Deputy District Attorney. It was a challenging position.. The other District Attorneys probably required more supervision than the genial Chief provided, but he avoided serious scandals and major debacles. Some particular memories endure.. We all found ourselves in court against a pro per defendant who had more jury trial experience than all of the DA s staff combined.(*) I recall one drunk driving trial which he defended by arguing that it was not alcohol but battery acid that he had consumed to excess on that particular evening.(**). There was an older defense attorney (***) who officed in the hall ways and was occasionally ...
Investigations on various aspects of plant-pathogen interactions have the ultimate aim of providing information that may be useful for the development of effective crop disease management systems. Molecular techniques have accelerated the formulation of short- and long-term strategies of disease management. Exclusion and eradication of plant pathogens by rapid and precise detection and identification of microbial pathogens in symptomatic and asymptomatic plants and planting materials by employing molecular methods has been practiced extensively by quarantines and certification programs with a decisive advantage. Identification of sources of resistance genes, cloning and characterization of desired resistance genes and incorporation of resistance gene(s) into cultivars and transformation of plants with selected gene(s) have been successfully performed by applying appropriate molecular techniques. Induction of resistance in susceptible cultivars by using biotic and abiotic inducers of resistance ...
Sancho reached his master so limp and faint that he could not urge on his beast. When Don Quixote saw the state he was in he said, "I have now come to the conclusion, good Sancho, that this castle or inn is beyond a doubt enchanted, because those who have so atrociously diverted themselves with thee, what can they be but phantoms or beings of another world? and I hold this confirmed by having noticed that when I was by the wall of the yard witnessing the acts of thy sad tragedy, it was out of my power to mount upon it, nor could I even dismount from Rocinante, because they no doubt had me enchanted; for I swear to thee by the faith of what I am that if I had been able to climb up or dismount, I would have avenged thee in such a way that those braggart thieves would have remembered their freak for ever, even though in so doing I knew that I contravened the laws of chivalry, which, as I have often told thee, do not permit a knight to lay hands on him who is not one, save in case of urgent and ...
The loss of hippocampal and cortical synapses, resulting from impaired synaptogenesis, accelerated synaptic degeneration, or both, is one of the earliest neuropathologic findings in Alzheimers Disease and is the finding that best correlates with cognitive symptoms (DeKosky & Scheff, 1990; Terry, et al, 1991; Selkoe, 2002). A similar decrease in brain synapses is an early finding in an animal model of AD which overproduces A-beta peptides (Jacobsen, et al, 2006), and aggregates of such peptides, applied locally to the brain, can also damage synapses, distort neurites, and decrease the numbers of the dendritic spines which are essential precursors for glutamatergic synapses (Jacobsen, et al, 2006; Knobloch & Mansuy, 2008; Spires-Jones, et al, 2007). These observations have supported the widely-held view that a treatment that would block the synthesis of A-beta or remove it from the circulation, might - by depleting its levels in brain - slow the loss of synapses in AD and thereby sustain cognitive
If your child suffered birth injuries, our Naperville attorneys can help you get the compensation you need. Call Chute, OMalley, Knobloch & Turcy, LLC today to get started.
2150-0060 recognizes human Collagen type II, an extracellular matrix protein found mainly in cartilaginous tissue. The antibody reacts with both native and
x TABLE OF CONTENT ACKNOWLEDGEMENTS ENGLISH ABSTRACT THAI ABSTRACT LIST OF TABLES LIST OF FIGURES ABBREVIATIONS iii iv vii xv xvi xviii CHAPTER I: INTRODUCTION 1.1 Statement of problems Literature
List of Contributors. Foreword.. Preface.. Part 1 The Science of Genomics and Genetics.. 1 The Human Genome and Epigenome (john j. mulvihill, klaas j. wierenga and chad m. kerksick).. 2 Mitochondrial Medicine in Health and Disease: Interface Between Athletic Performance and Therapeutics (douglas c. wallace).. 3 Characterizing the Extent of Human Genetic Variation for Performance-Related Traits (john blangero and jack w. kent jr.).. 4 Current Proteome Profiling Methods (yetrib hathout, catherine a. formolo, kristy j. brown and javad nazarian).. 5 Bioinformatics and Public Access Resources (yue wang, huai li, david j. miller and jianhua xuan).. 6 Search for Genes Influencing Complex Traits (corneliu henegar, henri hooton and karine clément).. Part 2 Evidence from Genetic Epidemiology Studies.. 7 Genetic Epidemiology, Physical Activity, and Inactivity (molly s. bray, janet e. fulton, nishan sudheera kalupahana and j. timothy lightfoot).. 8 Role of Genetics Factors in Sport Performance: Evidence ...
Collagen, type XV, alpha 1, also known as COL15A1, is a human gene.[1] This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.[1] ...
The key is theres no initial investment, I mean you get payback in the first year which is usually not what you talk about when you talk about return on investment,Award Winning solarpanel and heat pumps for electricity and heating. you talk about getting it back on a 5 to 7-year period and theres savings the first year even with these assumptions," Chief Financial Officer Noel Knobloch said ...
University of California Berkeley THE LIBRARY OF THE UNIVERSITY OF CALIFORNIA BEQUEST OF ANITA D. S. BLAKE f . . y THE SONG OF HIAWATHA. BY HENRY WADSWORTH LONGFELLOW. LONDON: DAVID BOGUE, FLEET STREET. MDCCCLV. LONDON : Printed by G. BARCLAY, Castle St. Leicester Sq. CONTENTS. PAGE INTRODUCTION ..... 3 I. THE PEACE-PIPE . . . . 11 II. THE FOUR WINDS .... 20 in. HIAWATHAS CHILDHOOD ... 36 IV. HIAWATHA AND MUDJEKEEWIS . . 49 v. HIAWATHAS FASTING ... 65 vi. HIAWATHAS FRIENDS ... 80 vii. HIAWATHAS SAILING ... 90 vni. HIAWATHAS FISHING ... 98 IX. HIAWATHA AND THE PEARL- FEATHER . Ill x. HIAWATHAS WOOING . . . 127 xi. HIAWATHAS WEDDING-FEAST 142 iv CONTENTS. PAGE XII. THE SON OF THE EVENING STAR . . 155 XIII. BLESSING THE CORN-FIELDS . . 175 XIV. PICTURE-WRITING ... 188 xv. HIAWATHAS LAMENTATION . 198 XVI. PAU-PUK-KEEWIS .... 210 XVII. THE HUNTING OF PAU-PUK-KEEWIS . 224 XVIII. THE DEATH OF KWASIND . . . 213 XIX. THE GHOSTS ..... 250 XX. THE FAMINE 262 XXI. THE WHITE MAN ? S FOOT ... 272 ...
H., 423. Bland, Lt. R. E., 11. Blanton, Lt. W. M., 384. Blasinedine, Lt. C. T., 96. Blassingame, Capt. J. H., 123. Blocker, Asst. Surg. J. E., 246. Blunt, Capt. J. C., 368. Blythe, Capt. A. L., 231. Boatwright, Capt., James, 368. Boggan, Lt. J. A., 263. Boggs, Chaplain W. E., 123. Bohannon, Ensign, Wm., 72. Boiling, Jr., Capt. Geo. W., 2. Boiling, Lt., Wm. N., 2. Bolton, Capt. H., 357. Bolton, Chaplain J. H., 263. Bolton, Lt. J. W., 286. Bond, Capt., Antrobus, 71. Boone, Capt., Thos. D., 253. Boone, Lt. W. R., 286. Borland, Capt., Euclid, 347. Bost, Capt. R. A., 275. Bost, Maj., Thos. L., 359. Bostic, Lt. T. J., 263. Boteler, Col. A. R, 185. Boulware, Asst Surg. J. R., 123. Bowen, Hos. Stewd A. H., 46. Bowen, Capt. B. A., 314. Bowen, Capt. D., 326. Bowen, Lt. James F., 96. Bowen, Col. R. E., 121. Bower, Lt. C. A., 13, 49. Bowers, U. S. A. Col., XVIII. Bowie, Lt. R. E., 122. Boyd, Lt., E. Holmes, 84. Boyd, Capt. J. W., 109. Boyd, ...
This papyrus, the tattered remains (about 1,000 letters) of an elegant roll, was edited by C. H. Roberts in vol. xviii of The Oxyrhynchus Papyri, published in 1941. Out of a total of fifty-three fragments he located twenty-nine; the twenty-four which he left unlocated are mere scraps, averaging six-and-a-half letters (maximum twelve, minimum two), with about a third of their letters represented by ambiguous and sometimes minimal remains. This chapter summarizes the following: (a) hitherto unknown, and possibly true: 524, 528; (b) hitherto unknown, and evidently false: 109, 438; (c) agreeing with a true variant against a false: 294, 461, 525; (d) agreeing with the medieval tradition in a reading which is commonly corrected: 200.
COLUMBUS. WEDNESDAY EVENING. JULY ll 1855. NUMBER 295. VOLUME XVIII. f taic $0tmwL bio IB PimUSURD DAILY, TRI-WEEKLY AND WEEKLY T TBI OHIO STATE JOURNAL COMPANY. Incorporated under the General Law. fERM3, INVARIABLY IN ADVANCE; nuiT a 00 per year. By the Carrier, per week 12X cts. TK. Wrani.T J0 per year. Wkkkit 2 0(1 " ciubs of ten and over 160 " TERMS OF ADVERTISING BV THE SQUARE. (TEI LINES OR tKW aUKl aqrMBI.) One square 1 year . . $20 00 ; one square 3 weoks . . . J 60 One " 9 months 1 00 ; on. " 2 weeks. ..2 60 One " montha 13 00 ; one " 1 week.... 1 60 On. " 8 month. 8 00 ; one " 6 days 1 38 One " 2month 6 00 ; one " 4 days 126 one " 6 week a 5 00 ; one " 8 day... .110 One " 1 montU 4 60 one " 1 iuserti.n 60 Displayed advertisement, half more than the above "Advertisements, leaded and placed In the column of SpedlNotlcca,,oubllnwd!narMrart. All notices required to be published by law, legal rates. If ordered on the inside exclusively after the first week. 60 per cent, more than the ...
liliTIirTf-TfJirirjIJI rilTOJgMI I jj jjTjgJIBlMMMWIi Mi llsMalgesaaewaeeWgiejgia VOLUME XVIII. COLUMBUS. TUESDAY EVENING, JULY 31, 1855. NUMBER 312 bio dilate hwxml a rcmjs8K DAlXY, TRI-TTEEKLT AND WEEKLY BY Till II 1(1 STATE JOURNAL COMPANY. Incorporated under the General Law. ERM9, INVARIABLY IN ADVAITCE Daily B 00 paryaar- By the Carrier, per week V2. ct. 7hi-Wkkkit 00 per year. , Wfeklt 2 00 Clubs of ton and over 160 11 TERMS OF ADrERTISIXO BY THE SQUARE. (test lutes or liss makb a squab.) One square 1 rear ..$20 00 ; one square 8 weeks.. .to 60 One " 9 months 18 00 ; ono " 2 weeks.. . 2 60 One 6 rauntha 12 00 ; ono 14 1 weak.... 160 One " 3 mouths 8 00 ; one " 6 -lays 138 One 2 months 6 00 ; one " 4 days 126 One " 6 woeks 6 00 ; one 41 3 days 110 One 1 month 4 60 one " 1 insertl.n 60 Displayed advertisements half more than the above rates. Advertisement, leaded and placed in the column ol Special Notices,1 double ihtt ordinary rate$. All notices required to be published by law, ...
The spa town, Enghien-les-Bains, began as the Prince of Condés hamlet in 1689. While on a walk near the "pond" in 1766, Abby Louis Cotte happens upon the sulfurous waters. Once the waters are taken to heal an ulcer in the leg of Louis XVIII in 1823, the hamlet becomes a popular destination. The National Assembly declares ts official birth date of 1850. From Gare du Nord, the trip takes less than 15 minutes (seven miles from Paris) to Enghien-les-Bains….. Read more →. ...
Pages H4269-H4308] From the Congressional Record Online through the Government Publishing Office [www.gpo.gov] ENERGY AND WATER DEVELOPMENT AND RELATED AGENCIES APPROPRIATIONS ACT, 2014 The SPEAKER pro tempore. Pursuant to House Resolution 288 and rule XVIII, the Chair declares the House in the Committee of the Whole House on the state of the Union for the further consideration of the bill, H.R. 2609. Will the gentlewoman from Florida (Ms. Ros-Lehtinen) kindly resume the chair. {time} 1900 In the Committee of the Whole Accordingly, the House resolved itself into the Committee of the Whole House on the state of the Union for the further consideration of the bill making appropriations for energy and water development and related agencies for the fiscal year ending September 30, 2014, and for other purposes, with Ms. Ros-Lehtinen (Acting Chair) in the chair. The Clerk read the title of the bill. Ms. ROS-LEHTINEN. When the Committee of the Whole rose earlier today, the amendment offered by the ...
Cambridge: Cambridge University Press, 1988. xviii, 280p., scattered period illustrations, second printing openweave orange cloth boards, a very good copy lacking the jacket. Literary assessments, John Muir to Frank Norris to Raymond Chandler. Cambridge studies in American literature and culture. Editor: Albert Gelpi. Cat.No: 165889 ISBN: 0201144794
About this Quotation: After the strict and heavy handed censorship of the Napoleonic Empire there was a brief period of press freedom during the First Restoration of the Bourbon monarchy under King Louis XVIII (April 1814 - March 1815). The restored Bourbon monarchy declared freedom of the press on 4 June 1814 which led to the creation of a full spectrum of political debate and argument among the 20 new titles which emerged. However, by October 1814 new censorship laws had been passed in order to control political criticism of the new regime. All publications less than 20 pages long (so most papers and journals) had to have their material approved by government officials before they could be published. These laws were made even more restrictive in November 1815. There was another liberalizaton of the censorship laws in late 1818 under the ministry of Dessoles-Decazes with the Serre press laws but this was short lived as the assassination of the Duke de Berry in February 1820 led to a severe ...
Complete information for COL15A1 gene (Protein Coding), Collagen Type XV Alpha 1 Chain, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
The vitreoretinopathy is a group of genetically and clinically heterogeneous disorders including exudative vitreoretinopathy, Knobloch syndrome, Snowflake vitreoretinal degeneration, Stickler syndrome, and Wagner syndrome. The eye findings vary from mild to severe and they may include decreased visual acuity, blindness, myopia, cataract, glaucoma, exudative vitreoretinopathy, vitreoretinal degeneration, retinal detachment, neovascularization, peripheral retinal avascularization, and temporal stretching of retinal vessels.. The vitreoretinopathy NGS panel consists of nineteen genes: BEST1, CAPN5, FZD4, COL2A1, COL9A1, COL9A2, COL9A3, COL11A1, COL11A2, COL18A1, KCNJ13, KIF11, LRP5, NDP, NR2E3, RS1, TSPAN12, VCAN and ZNF408.. Copy number variation (CNV) analysis of the vitreoretinopathy genes is also offered as a panel. Additionally, CTGT offers a comprehensive test (both NGS and CNV panels) for these genes. Panel genes are also offered as individual sequencing and deletion/duplication tests unless ...
Postischemic hypothermia protects against loss of agrin and SPARC from the vascular basement membrane in global cerebral ischemia
H. Anklin, J.-P. Blaizot, H. Borel, E. Cisbani, N. dHose, J.-E. Ducret, A. Feltham, D. Fritschi, S. Frullani, S. Gardner, F. Garibaldi, J. Gomez, J. ; Goetz, E. Jans, M. Jodice, J. Jourdan, S. Kerhoas, B.Z. Kopeliovich, L. Lapikas, J. LeRose, M. Loppacher, J. Marroncle, G. Masson, J. Morgenstern, N.N. Nikolaev, G. Piller, B. Pire, M. Potokar, L.M. Qin, A. Richter, S. Robinson, A. Saha, I. Sick, F. Staley, G. van der Steenhoven, Ph. Steiner, A. Szczurek, Ph. Trueb, M. Tuccillo, P. Ulmer, G.M. Urcioli, P. Vernin, M.B. Zhalov, B.G. Zakharov, M. Zeier, B. Zihlmann, V.R. Zoller, A decisive test of color transparency by quasielastic (e,ep) scattering at high Q2, Atti conference Società Italiana di fizica, 44, 223-240 (1993) [The ELFE Project, an electron laboratory for Europe: physics with a 15-30 GeV high intensity continuous beam electron accelerator : Mainz, Germany, 7-9 October 1992. Ed. by J. Arvieux, E. De Sanctis, Ital. Phys. Soc, 1993, xviii+709 pp. ISBN 8877940603, 9788877940605]. ...
California .egional acility t PLEAF*: DO NOT REMOVE THIS BOOK GARDI ^^•LIBRARY(9/^ JITI University Research Librq^y "TT m 03 This book is DUE on iast date stamped below Mi? 1962 yS SEFl tii ^^030 ^m ^ertp ^otictp. EARLY ENGLISH POETRY, BALLADS, AND POPULAR LITERATURE OF THE MIDDLE AGES. EDITED FROM ORIGINAL MANUSCRIPTS AND SCARCE PUBLICATIONS. 453S3 VOL. XVIII. LONDON; PRINTED FOR THE PERCY SOCIETY, BY T. RICHARDS, ST MARTINS LANE. M.DCCO.XLVI. ?R\\o\ V. \8 CONTENTS OF VOL. XVIII. THE PASTIME OF PLEASUKE. I(\ STEFHEN llAWiS. PASTIME OF PLEASURE: Sin ^llcprical Porm, STEPHEN HAWES RK.rRrNTED VROM THE EDITION OF 1555. LONDON : PRINTED FOR THE PERCY SOCIETY, BY T. RICHARDS, 100, ST. MARTINS LANE. M.UCCC.XLV. Council, 1845-6. President, The Rt. Hon. LORD BRAYBROOKE, F.S.A. THOMAS AMYOT, Esq. F.R.S. Treas. S.A. WILLIAM HENRY BLACK, Esq. WILLIAM CHAPPELL, Esq. F.S.A. J. PAYNE COLLIER, Esq. F.S.A. BOLTON CORNEY, Esq. T. CROFTON CROKER, Esq. F.R.S., M.R.I.A. JAMES HENRY DIXON, Esq. FREDERICK VV. ...
Today, the U.S. Food and Drug Administration granted accelerated approval to Xpovio (selinexor) tablets in combination with the corticosteroid dexamethasone for the treatment of adult patients with relapsed refractory multiple myeloma who have received at least four prior therapies and whose disease is resistant to several other forms of treatment, including at least two proteasome inhibitors, at least two immunomodulatory agents, and an anti-CD38 monoclonal antibody.. ...
It has been reported that biglycan interacts more strongly with collagen type II than collagen type I. Biglycan has been ... Pogány G, Hernandez DJ, Vogel KG (August 1994). "The in vitro interaction of proteoglycans with type I collagen is modulated by ... "Binding of the proteoglycan decorin to collagen type VI". J. Biol. Chem. 267 (8): 5250-6. PMID 1544908. Bowe MA, Mendis DB, ... "Interaction of biglycan with type I collagen". J. Biol. Chem. 270 (6): 2776-83. doi:10.1074/jbc.270.6.2776. PMID 7852349. ...
This condition is caused by a mutation of COL7A1, the gene that codes for a type of collagen 7. Epidermis (skin) Dermis Lamina ... Anchoring fibrils (composed largely of type VII collagen) extend from the basal lamina of epithelial cells and attach to the ... Keene, Douglas R.; Sakai, Lynn Y.; Lunstrum, Gregory P.; Morris, Nicholas P.; Burgeson, Robert E. (1987). "Type VII collagen ... Burgeson, Robert E. (1993). "Type VII Collagen, Anchoring Fibrils, and Epidermolysis Bullosa". Journal of Investigative ...
Type I collagen composes 90-95% of the organic matrix, with remainder of the matrix being a homogenous liquid called ground ... These synthesise collagen within the cell, and then secrete collagen fibrils. The collagen fibers rapidly polymerise to form ... Osteoid is primarily composed of Type I collagen. Osteoblasts also manufacture hormones, such as prostaglandins, to act on the ... This matrix consists of organic components, mainly type I collagen - "organic" referring to materials produced as a result of ...
Collagen type IV alpha-3-binding protein, also known as ceramide transfer protein (CERT) or StAR-related lipid transfer protein ... "Entrez Gene: COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein". Merrill AH (Jul 2002). "De novo ... that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, ... PH domain of wild-type CERT has been found to recognize specifically PI4P and therefore CERT targets the Golgi apparatus or the ...
Retrieved from "https://en.wikipedia.org/w/index.php?title=Collagen,_type_XX,_alpha_1&oldid=705418915" ... This page was last edited on 17 February 2016, at 11:18 (UTC). ... Collagen, type XX, alpha 1. From Wikipedia, the free ...
... is a naturally occurring, 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an ... Other collagen derived antiangiogenic factors include arresten, canstatin, tumstatin, α 6 collagen type IV antiangiogenic ... It is produced by proteolytic cleavage of collagen XVIII, a member of the multiplexin family that is characterized by ... Marneros, A.G.; Olsen, B.R. (2005). "Physiological role of collagen XVIII and endostatin". The FASEB Journal. 19 (7): 716-28. ...
Type-IV collagen is present in the basement membrane within normal lungs, and this is reduced in asthmatic patients. There are ... The structure is very similar to that of endostatin, which is cleaved from collagen XVIII. The two proteins share 14% amino ... Tumstatin is a 28 kDa fragment cleaved from collagen type IV There are two subsegments of the peptide that are active; T3 ... Since tumstatin is cleaved by MMP from the collagen in the basement membrane, it has been found that there are much lower ...
Horton, WA, Campbell, D, Machado, MA & Chou, J; Campbell; Machado; Chou (1989). "Type II collagen screening in the human ... "Collagen XVIII mutation in Knobloch syndrome with acute lymphoblastic leukemia".American journal of medical genetics. Part A ... Gajko-Galicka, A (2002). "Mutations in type I collagen genes resulting in osteogenesis imperfecta in humans". Acta biochimica ... "Ehlers-Danlos syndrome and type III collagen abnormalities: a variable clinical spectrum". Clinical Genetics 53 (6): 440-446. ...
"A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". The Journal of Biological Chemistry. 277 ... "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". The Journal of Biological Chemistry. 277 ... One type, MafA, also known as RIPE3b1, promotes pancreatic development, as well as insulin gene transcription. MAF has been ... 18 (5): 2729-37. PMC 110652 . PMID 9566892. Chesi M, Bergsagel PL, Shonukan OO, Martelli ML, Brents LA, Chen T, Schröck E, Ried ...
These mice have greater susceptibility to an asthma-like phenotype than wild-type animals. They are resistant to collagen- ... Two years is a common life expectancy in wild-type house mice. FVB mice show above average activity and anxiety. Because of ... Rods are lost within 9 weeks of birth, while cones may persist until 18 months of age. ...
Type II collagen can help distinguish it from other tumors. Mesenchyme sarcoma Hoang MP, Suarez PA, Donner LR, et al. (October ... 1 (6). Müller S, Söder S, Oliveira AM, Inwards CY, Aigner T (August 2005). "Type II collagen as specific marker for mesenchymal ...
Periosteum covered versus type I/III collagen covered". Knee. 13 (3): 203-10. doi:10.1016/j.knee.2006.02.011. ISSN 0968-0160. ... "Autologous chondrocyte implantation in chondral defects of the knee with a type I/III collagen membrane: A prospective study ... "Use of a type I/III bilayer collagen membrane decreases reoperation rates for symptomatic hypertrophy after autologous ... The correctly sized collagen membrane is added to the microfractured area either by fibrin glue (autologous or commercially ...
This type of collagen is found in the basement membranes of various body tissues. Its deficiency in the eye is thought to be ... These mutations have been found in the COL18A1 gene that instructs for the formation of a protein that builds collagen XVIII. ... When caused by mutations in the COL18A1 gene it is called Knobloch syndrome type 1. The genes causing types II and III have yet ... "Mapping of a novel type III variant of Knobloch syndrome (KNO3) to chromosome 17q11.2". Am J Med Genet A. 143A: 2768-74. doi: ...
The main substrates of the gelatinases are type IV collagen and gelatin, and these enzymes are distinguished by the presence of ... All six membrane-type MMPs (#14, No. 15, #16, No. 17, #24, and #25) have a furin cleavage site in the pro-peptide, which is a ... These collagens are the major components of bone, cartilage and dentin, and MMPs are the only known mammalian enzymes capable ... 14 has also been shown to cleave fibrillar collagen, and there is evidence that No. 2 is capable of collagenolysis. In MeSH, ...
The vascular basement membrane is composed of type IV collagen, type XV collagen, type XVIII collagen, laminins, entactin, ... As previously described, MMPs have been shown to cleave plasminogen and collagen XVIII into the endogenous angiogenesis ... Endostatin is a 20 kDa fragment of collagen XVIII. The major role of endostatin is in its ability to potently inhibit ... in different in vitro and in vivo models by blocking EC adhesion to various substrate such as fibronectin and type I collagen. ...
Investigators found that HSPGs such as perlecan and collagen type XVIII are modified during human renal ischemia/reperfusion, ... Sulf1/2 expression resulted in more ECM (collagen fibril deposition) than control tumors, which may be another mechanism by ... were largely as healthy and viable as wild type litter mates. MSulf2 nulls indicate MSulf1 and MSulf2 may have overlapping ... 134 (18): 3327-38. doi:10.1242/dev.007674. PMID 17720696. Danesin C, Agius E, Escalas N, Ai X, Emerson C, Cochard P, Soula C ( ...
The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in ... During embryonic development, MMP13 is expressed in the skeleton as required for restructuring the collagen matrix for bone ... Although the actual mechanism has not been described, the hemopexin domain participates in collagen degradation, the catalytic ... 2000). "Hydrolysis of triple-helical collagen peptide models by matrix metalloproteinases". J. Biol. Chem. 275 (18): 13282-90. ...
... commonly cartilage or collagen) or type of soft palate lengthening procedure (i.e. VY palatoplasty). Conley SF, Gosain AK, ... The most frequent types of cleft palates are overt, submucous, and occult submucous. While cleft is the most common cause of ... 18 (1): 38-46. doi:10.1016/S0196-0709(97)90047-8. PMID 9006676. Johns DF, Rohrich RJ, Awada M (2003). "Velopharyngeal ...
Type III[edit]. Collagen improperly formed, enough collagen is made but it is defective. ... Similar to Type I, Type IV can be further subclassified into types IVA and IVB characterized by absence (IVA) or presence (IVB ... There are eight types, with type I being the least severe and type II the most severe.[1] Diagnosis is often based on symptoms ... The underlying mechanism is usually a problem with connective tissue due to a lack of type I collagen.[1] This occurs in more ...
Platelet activation (through agonists such as thrombin, Type II collagen and ADP) results in "membrane flipping" where the ... The extracellular region of P-selectin is composed of three different domains like other selectin types; a C-type lectin-like ... a type of glycosaminoglycan (GAG). Its activity in tumor metastasis has been probed by the addition of heparin that functions ... The number of CRP repeats is the major feature differentiating the type of selectin in extracellular region. In human, P- ...
... its effect on paraproteinemia and the urinary N-telopeptide of type I collagen bone turnover marker". Clinical Cancer Research ... 15 (18): 5917-22. doi:10.1158/1078-0432.CCR-08-2217. PMID 19737963. Rajkumar, SV (Sep 15, 2009). "Prevention of progression in ... 15 (18): 5606-8. doi:10.1158/1078-0432.CCR-09-1575. PMC 2759099 . PMID 19737944. Berenson, JR; Anderson, KC; Audell, RA; Boccia ...
Peng Y.; Glattauer V.; Werkmeister J. A.; Ramshaw J. A. M. (2004). "Evaluation for collagen products for cosmetic application ... Scientists are also working to discover different types of humectants; a study published in 2011 concluded that extracts from ... and collagen.[18] Glycerin is one of the most popular humectants used because it produces the desired result fairly frequently ...
... and homocitrulline-containing peptides related to type I and II collagen telopeptides. Arthritis Research & Therapy, 17(1):2 ... Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17372-7. Turunen S, Hannonen P, Koivula M-K, Risteli L, Risteli J. Separate and ...
... or KNO may refer to: Kno, an American education software company Collagen, type XVIII, alpha 1, a protein Kno (musician) ( ...
16] Kostin S, Types of cardiomyocyte death and clinical outcomes in patients with heart failure. Journal of American College of ... However, fibroblasts have the function of generating connective tissue matrix, specifically, collagen. The distinction between ... Telocytes are a novel defined type of interstitial (stromal) cells, in the field of Stem cells, with very long (tens to ... A telocyte (blue) telopode is engaged in different types of synapses with a plasma cell: two plain synapses (PS) and one ...
Several types of catenins work with N-cadherins to play an important role in learning and memory (For full article, see ... Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR (October 2011). "A role for collagen XXIII in cancer cell ... For instance, higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened ... levels of collagen helped facilitate adhesions and anchorage-independent cell growth and provided evidence of collagen XXIII's ...
COL18A1, KNO, KNO1, KS, Collagen, type XVIII, alpha 1, collagen type XVIII alpha 1, collagen type XVIII alpha 1 chain. ... "Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to ... This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix ... 2002). "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are ...
Type XVIII collagen is a type of collagen which can be cleaved to form endostatin. Collagen Type XVIII at the US National ...
"Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to ... This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix ... 2002). "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are ... "Entrez Gene: COL18A1 collagen, type XVIII, alpha 1". Pufe T, Kurz B, Petersen W, et al. (2006). "The influence of biomechanical ...
COL18A1 collagen type XVIII alpha 1 chain [Homo sapiens] COL18A1 collagen type XVIII alpha 1 chain [Homo sapiens]. Gene ID: ... XVIII) chain. Names. antiangiogenic agent. collagen alpha-1(XVIII) chain isoform 1 preproprotein. collagen, type XVIII, alpha 1 ... CRD_Collagen_XVIII; Cysteine-rich domain of the variant 3 of collagen XVIII (V3C18 ). pfam01391. Location:1057 → 1107. Collagen ... This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix ...
COL18A1 collagen type XVIII alpha 1 chain [Canis lupus familiaris] COL18A1 collagen type XVIII alpha 1 chain [Canis lupus ... LOW QUALITY PROTEIN: collagen alpha-1(XVIII) chain. Names. collagen, type XVIII, alpha 1. endostatin. ... collagen type XVIII alpha 1 chainprovided by VGNC. Primary source. VGNC:VGNC:49781 See related. Ensembl:ENSCAFG00000011817 Gene ... COL18A1 collagen type XVIII alpha 1 chain [ Canis lupus familiaris (dog) ] Gene ID: 100687767, updated on 26-Sep-2018 ...
... type XVIII collagen, and results in rapid death. The type-XVIII-collagen-dependent response to liver injury is mediated by ... Type XVIII collagen is essential for survival during acute liver injury in mice.. [Michael B Duncan, Changqing Yang, ... These findings demonstrate that type XVIII collagen is an important functional component of the liver matrix microenvironment ... Type in Product Names, Product Numbers, or CAS Numbers to see suggestions. ...
The mouse gene for the alpha 1 chain of type XVIII collagen (Col18a1) is more than 102 kb and consists of 43 exons. Type XVIII ... Characterization of the mouse gene for the alpha 1 chain of type XVIII collagen (Col18a1) reveals that the three variant N- ... The marked differences previously observed in the expression of variant type XVIII collagen transcripts in mouse tissues thus ... Publication type, MeSH terms, Substances, Secondary source ID. Publication type. *Research Support, Non-U.S. Govt ...
Non-fibrillar collagens [endoplasmic reticulum lumen] (Homo sapiens) * Collagen type XVIII [endoplasmic reticulum lumen] (Homo ... Non-fibrillar collagens [endoplasmic reticulum lumen] (Homo sapiens) * Collagen type XVIII [endoplasmic reticulum lumen] (Homo ... C-linked procollagen type XVIII trimer [endoplasmic reticulum lumen] (Bos taurus) C-linked procollagen type XVIII trimer [ ... C-linked procollagen type XVIII trimer [endoplasmic reticulum lumen] (Danio rerio) C-linked procollagen type XVIII trimer [ ...
COL18A1; collagen, type XVIII, alpha 1; KNO, Knobloch syndrome, type 1; collagen alpha-1(XVIII) chain; endostatin; KNO1; KS; ... Type XVIII, Alpha 1. Yeast. Mouse. N/A. +Inquiry. Col18a1-200M. Recombinant Murine Collagen, Type XVIII, Alpha 1, Fc Chimera. ... Recombinant Human Collagen, Type XVIII, Alpha 1. E. coli. Human. N/A. +Inquiry. ... Recombinant Mouse Collagen, Type XVIII, Alpha 1. S. frugiperda. Mouse. N/A. +Inquiry. ...
Type XVIII collagen is a type of collagen which can be cleaved to form endostatin. ... File:Schematic representation of the human collagen XVIII variants.jpg Schematic representation of the human collagen XVIII ... Collagen+Type+XVIII at the US National Library of Medicine Medical Subject Headings (MeSH) ... Retrieved from "https://www.wikidoc.org/index.php?title=Type_XVIII_collagen&oldid=1419779" ...
Genetic and Rare Diseases Information Center resources: Keratoconus Chiari Malformation Type 2 ... Study of the Safety and Effectiveness of Collagen Cross-Linking at an Irradiance of 9 mW/cm2 and 18 mW/cm2. The safety and ... Study of the Safety and Effectiveness of Photochemically Induced Collagen Cross-Linking at an Irradiance of 9 mW/cm2 and 18 mW/ ... The primary objective of this study is to determine the effectiveness and safety of corneal collagen cross-linking at ...
Western blotting confirmed elevated type XVIII collagen precursor levels in the plasma and lavage and multiple endostatin-like ... Endostatin is a 20 to 28 kDa proteolytic fragment of the basement membrane collagen XVIII, which has been shown to inhibit ... Elevated type XVIII collagen precursors in the plasma of ALI patients compared with normal controls is shown. ALI = acute lung ...
Collagen Type XVIII Alpha 1 Chain, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - ... Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to ... This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix ... Collagen Type XVIII Alpha 1 Chain) is a Protein Coding gene. Diseases associated with COL18A1 include Knobloch Syndrome, Type 1 ...
Study November 18, 2015 - Rheumatoid Arthritis flashcards from Chris Oleynick ... Type 2 Collagen. - Proteoglycans. - Chondrocytes. - Immunoglobulins (IgG). 3 Fibroblasts in Rheumatoid Arthritis ... November 18, 2015 - Rheumatoid Arthritis Flashcards Preview COURSE 2 , November 18, 2015 - Rheumatoid Arthritis , Flashcards ...
Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. Here the D is approximately 67 nm and ... These form the most abundant collagens in vertebrates. ... There are 29 genetically distinct collagens present in animal ... Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen ... XVIII. source of endostatin. COL18A1. -. XIX. FACIT collagen. COL19A1. -. XX. -. COL20A1. -. XXI. FACIT collagen. COL21A1. -. ...
... when adherent to type V collagen. Yet, staurosporine induced Akt and Erk activation on H295R cells: the adhesion on type V ... Adrenocortical cancer Type V collagen Apoptosis Staurosporine This is a preview of subscription content, log in to check access ... Luparello C, David F, Campisi G, Sirchia R. T47-D cells and type V collagen: a model for the study of apoptotic gene expression ... Luparello C, Sirchia R, Longo A. Type V collagen and protein kinase Cη down-regulation in 8701-BC breast cancer cells. Mol ...
Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II ... Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol Rev 1990; 118: 193-232.. Direct Link: ... Analysis of type I and IV collagens by FT-IR spectroscopy and imaging for a molecular investigation of skeletal muscle ... Antibodies to type II collagen in early rheumatoid arthritis: correlation with disease progression. Arthritis Rheum 1996; 39: ...
Stress heterogeneities in sheared type-I collagen networks revealed by Boundary Stress Microscopy. ... Live Cell Imaging and 3D Analysis of Angiotensin Receptor Type 1a Trafficking in Transfected Human Embryonic Kidney Cells Using ... Preoperative Inferior Mesenteric Artery Embolization: A Valid Method to Reduce the Rate of Type II Endoleak after EVAR? ... A novel 3D fibril force assay implicates src in tumor cell force generation in collagen networks. ...
... the collagen fibres are tilted out of the image plane. Both positive and negative areas of SHG-CD are observed in microscopy ... of collagen to occur. The SHG-CD can be observed with the microscope when: (i) the chiral second-order susceptibility tensor ... in particular collagen, and provides basis for the interpretation of SHG-CD signals. The nonlinear imaging of chiroptical ... Nonlinear optical properties of collagen type-I are investigated in thin tissue sections of pig tendon as a research model ...
The purified mass is dried to provide the desired Type I collagen product which may be ground into a powder or formed into a ... The enzyme-treated comminuted material which is rich in collagen is dispersed in an organic acid to cause the fibrillar mass to ... source such as poultry feet that incorporates a fibrillar mass of connective tissue as well as bony tissue to yield a collagen ... collagen matrix or sponge, depending on the end use therefor. ... A process for extracting type I collagen from an avian ...
The purpose of this paper is to analyze the properties of fabricating rat tail type I collagen scaffolds cross-linked with ... Effect of UV irradiation on type I collagen fibril formation in neutral collagen solutions. Photodermatol Photoimmunol Photomed ... The purpose of this paper is to analyze the properties of fabricating rat tail type I collagen scaffolds cross-linked with ... Dong CM, Wu X, Caves J, Rele SS, Thomas BS et al (2005) Photomediated crosslinking of C6-cinnamate derivatized type I collagen ...
N2 - Type XV and type XVIII collagens are classified as part of multiplexin collagen superfamily and their C-terminal parts, ... AB - Type XV and type XVIII collagens are classified as part of multiplexin collagen superfamily and their C-terminal parts, ... Type XV and type XVIII collagens are classified as part of multiplexin collagen superfamily and their C-terminal parts, ... abstract = "Type XV and type XVIII collagens are classified as part of multiplexin collagen superfamily and their C-terminal ...
Drosophila type XV/XVIII collagen, Mp, is involved in Wingless distribution. Drosophila type XV/XVIII collagen, Mp, is involved ... Multiplexin (Mp) is the Drosophila orthologue of vertebrate collagens XV and XVIII. Like them, Mp is widely distributed in the ... Additional findings include the abnormal ultrastructure of fatbody associated with abnormal collagen IV deposition, and reduced ...
Face Masks For Your Skin Type. Skin Care 101: Face Masks July 9, 2013 by Kaitlyn Dreyling ... These types of masks can also be formulated with sulfur, tea tree oil, and witch hazel, which provide antibacterial and anti- ... Mario Badescu Super Collagen Mask. $18 from shop.nordstrom.com Buy Now ...
The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance ... The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance ... This chapter outlines several methods to assess the in vitro production of type I collagen that are employed in our laboratory ... Type I collagen Western immunoblot real-time PCR nuclear run-on assay ...
  • This is the collagen of granulation tissue, and is produced quickly by young fibroblasts before the tougher type I collagen is synthesized. (news-medical.net)
  • Bienkowski, R. S. (1984) Collagen degradation in human lung fibroblasts: extent of degradation, role of lysosomal proteases, and evaluation of an alternate hypothesis. (springer.com)
  • Smad7 constitutively formed a complex with the TGF-β receptors, and the inhibitory effect of Smad7 on the promoter activity of human α2(I) collagen and 3TP-lux was completely impaired in scleroderma fibroblasts. (jci.org)
  • Therefore, their functions should be mostly different: TC - intercellular signaling (connections), but fibroblasts - collagen synthesis. (wikipedia.org)
  • This type of granulomatous infection caused by P. curvatum is characterized by the presence of a number of Langhan-type giant cells, fibroblasts, macrophages surrounded by lymphocytes, as well as a decrease in the number of polymorphonuclear leukocytes. (wikipedia.org)
  • Furthermore, CCL18 is induced by fibroblasts, specifically by induction of collagen produced by fibroblasts, which is important in tissue healing and repair. (wikipedia.org)
  • In the reactive stroma hypothesis, tumor cells cause the proliferation of fibroblasts and subsequent secretion of collagen. (wikipedia.org)
  • The tumor-induced stromal change hypothesis claims that tumor cells can dedifferentiate into fibroblasts and, themselves, secrete more collagen. (wikipedia.org)
  • Most early refolding studies were performed with collagen type III which contains a disulfide linkage at the C-terminus of its triple helix (B chinger et al. (reactome.org)
  • OI is due to mutations involving several genes, the most commonly involved are the COL1A1 or COL1A2 genes which are responsible for the synthesis of the proalpha-1 and proalpha-2 polypeptide chains that form the type I collagen triple helix. (hindawi.com)
  • It is produced by proteolytic cleavage of collagen XVIII, a member of the multiplexin family that is characterized by interruptions in the triple helix creating multiple domains, by proteases such as cathepsins. (wikipedia.org)
  • MMPs were described initially by Jerome Gross and Charles Lapiere (1962), who observed enzymatic activity (collagen triple helix degradation) during tadpole tail metamorphosis (by placing a tadpole tail in a collagen matrix plate). (wikipedia.org)
  • The intermolecular and intramolecular bonds that stabilize insoluble collagen must be broken, and also, the hydrogen bonds that stabilize the collagen helix must be broken. (wikipedia.org)
  • These defects often cause problems in the biosynthesis of the collagen molecules, their assembly and posttranslational modification process that makes them their final end form of collagen. (news-medical.net)
  • Collagen-related diseases most commonly arise from genetic defects or nutritional deficiencies that affect the biosynthesis, assembly, postranslational modification, secretion, or other processes involved in normal collagen production. (news-medical.net)
  • Hydrolyzed collagen contains 8 out of 9 essential amino acids, including glycine and arginine-two amino-acid precursors necessary for the biosynthesis of creatine. (wikipedia.org)
  • Thus, PPIB is essential for collagen biosynthesis and post-translational modification and affects fibril assembly, matrix cross-linking, and bone mineralization. (wikipedia.org)
  • In corneas we can find two different types of proteoglycans: Chondroitin sulphate/dermatan sulphate (CD/DS) and keratan sulphate (KS). (wikipedia.org)
  • A balance between attractive and repulsive forces is reached for specific inter-fibrillar distances, which depends on the type of proteoglycans present. (wikipedia.org)
  • We describe Western immunoblotting of intact α1(I) collagen using antibodies directed to α1(I) collagen amino and carboxyl propeptides. (springer.com)
  • Studies with SpIII, an amino-terminal dimeric proteolytic fragment of vWF, show that this fragment can also support adhesion to collagen. (ahajournals.org)
  • Furthermore, possible recognition sequences for furin (a major physiological protease) cleavage sites have been found in both amino-terminal NC1 domain and carboxyl-terminal NC4 domain of each one of these collagens. (wikipedia.org)
  • Twenty chronic viral hepatitis patients, mainly with hepatitis B related with progression to liver cirrhosis were included for an assay of serum collagen markers: PICP (carboxy terminal propeptide of type I procollagen), PIIINP (amino terminal propeptide of type III procollagen), and 7S-IV (7S-domain type IV collagen). (springer.com)
  • The amino acid content of hydrolyzed collagen is the same as collagen. (wikipedia.org)
  • Hydrolyzed collagen contains 19 amino acids, predominantly glycine, proline and hydroxyproline, which together represent around 50% of the total amino acid content. (wikipedia.org)
  • This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, found in the amino terminal globular domain of all the alpha chains. (wikipedia.org)
  • The amino acid differences that distinguish between SFTPA2 and SFTPA1 genes and between their corresponding variants are located at the collagen-like domain. (wikipedia.org)
  • The amino acid differences that distinguish among SFTPA2 variants are located both at the carbohydrate recognition and the collagen-like domains. (wikipedia.org)
  • Renal tubular acidosis (proximal type) (Fanconi syndrome) occurs when the PTECs are unable to properly reabsorb glomerular filtrate so that there is increased loss of bicarbonate, glucose, amino acids, and phosphate. (wikipedia.org)
  • The 3D structures of the homologous Mn and Fe superoxide dismutases have the same arrangement of alpha-helices, and their active sites contain the same type and arrangement of amino acid side-chains. (wikipedia.org)
  • During hydrolysis, the natural molecular bonds between individual collagen strands are broken down into a form that rearranges more easily. (wikipedia.org)
  • The molecule of collagen XXIII can be found either in membrane-bond form or in shed form. (wikipedia.org)
  • It has been shown that in prostate collagen XXIII expression is associated with tumor progression. (wikipedia.org)
  • Collagen XXIII was first identified and isolated from rat prostate carcinoma cells by Jacqueline Banyard, Lere Bao and Bruce R. Zetter in 2003. (wikipedia.org)
  • They concluded that at the nucleotide level, human and rat collagen XXIII alpha 1 show 76% identity. (wikipedia.org)
  • It was demonstrated that the carboxyl terminus of collagen XXIII is present on the cell surface. (wikipedia.org)
  • This characteristic can be also applicable to collagen XXIII. (wikipedia.org)
  • It has been reported that the cell is able to regulate the amounts of collagen XXIII in the membrane-bound form and in the secreted shed form, influencing the production of one form or the other when it is needed. (wikipedia.org)
  • For that reason, the shedding process of collagen XXIII has been described as a selective proteolysis, carried out principally by furin, although there are other enzymes, like serine and cysteine proteases, which are able to shed the molecule too. (wikipedia.org)
  • The essential role of angiogenesis in tumor growth was first proposed in 1971 by Judah Folkman, who described tumors as "hot and bloody," illustrating that, at least for many tumor types, flush perfusion and even hyperemia are characteristic. (wikipedia.org)