A fibril-associated collagen found in many tissues bearing high tensile stress, such as TENDONS and LIGAMENTS. It is comprised of a trimer of three identical alpha1(XII) chains.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
The functions and properties of living organisms, including both the physical and chemical factors and processes, supporting life in single- or multi-cell organisms from their origin through the progression of life.
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
The functions and activities of living organisms that support life in single- or multi-cellular organisms from their origin through the progression of life.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).
A family of pattern recognition receptors characterized by an extracellular leucine-rich domain and a cytoplasmic domain that share homology with the INTERLEUKIN 1 RECEPTOR and the DROSOPHILA toll protein. Following pathogen recognition, toll-like receptors recruit and activate a variety of SIGNAL TRANSDUCING ADAPTOR PROTEINS.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).
A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA.
A pattern recognition receptor that forms heterodimers with TOLL-LIKE RECEPTOR 2.
A pattern recognition receptor that forms heterodimers with other TOLL-LIKE RECEPTORS. It interacts with multiple ligands including PEPTIDOGLYCAN, bacterial LIPOPROTEINS, lipoarabinomannan, and a variety of PORINS.
Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Proteins that are involved in the peptide chain termination reaction (PEPTIDE CHAIN TERMINATION, TRANSLATIONAL) on RIBOSOMES. They include codon-specific class-I release factors, which recognize stop signals (TERMINATOR CODON) in the MESSENGER RNA; and codon-nonspecific class-II release factors.
A family of the order Rodentia containing 250 genera including the two genera Mus (MICE) and Rattus (RATS), from which the laboratory inbred strains are developed. The fifteen subfamilies are SIGMODONTINAE (New World mice and rats), CRICETINAE, Spalacinae, Myospalacinae, Lophiomyinae, ARVICOLINAE, Platacanthomyinae, Nesomyinae, Otomyinae, Rhizomyinae, GERBILLINAE, Dendromurinae, Cricetomyinae, MURINAE (Old World mice and rats), and Hydromyinae.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.
A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.
Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM.
Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.
Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
An antibiotic mixture of two components, A and B, obtained from Nocardia lurida (or the same substance produced by any other means). It is no longer used clinically because of its toxicity. It causes platelet agglutination and blood coagulation and is used to assay those functions in vitro.
Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.
A genetic or pathological condition that is characterized by short stature and undersize. Abnormal skeletal growth usually results in an adult who is significantly below the average height.
Abnormal development of cartilage and bone.
Congenital structural abnormalities and deformities of the musculoskeletal system.
An autosomal dominant disorder that is the most frequent form of short-limb dwarfism. Affected individuals exhibit short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and mid-face hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, GENU VARUM, and trident hand. (Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim, MIM#100800, April 20, 2001)
A severe form of neonatal dwarfism with very short limbs. All cases have died at birth or later in the neonatal period.
Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).
Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.

Tensile stress-dependent collagen XII and fibronectin production by fibroblasts requires separate pathways. (1/14)

The intracellular mechanisms controlling mechano-dependent production of the two extracellular matrix proteins collagen XII and fibronectin were analyzed. Fibroblasts were cultured on either tensed (attached) or released (floating) collagen type-I gels, respectively. Collagen XII and fibronectin production was three- to fivefold higher under tensed than under released conditions. The general inhibitor of tyrosine phosphorylation, genistein (50 microM), and the MAP kinase inhibitor PD98059 (20 microM) selectively reduced collagen XII accumulation by tensed cultures. Addition of PD98059, but not genistein, downregulated tensile stress-induced tyrosine phosphorylation levels of ERK1/2 and focal adhesion kinase. Staurosporine as well as pretreatment with phorbol ester, which constitute means to downregulate classical and novel PKC activity, specifically blocked collagen XII but not fibronectin accumulation in tensed fibroblasts. ERK1/2 phosphorylation levels were not affected by staurosporine treatment. Chronic exposure to the protein kinase C inhibitors bisindolylmaleimide and calphostin C blocked increased production of both fibronectin and collagen XII from cells under tension. The data manifest that the mechano-dependent production of collagen XII and fibronectin requires separate pathways. The FAK-ERK1/2 pathway, a genistein-sensitive tyrosine kinase, and a distinct classical/novel PKC appear selectively required for increased production of collagen XII in cells under tensile stress, whereas fibronectin induction is regulated by a different PKC-dependent pathway.  (+info)

Differential expression of type XII collagen in developing chicken metatarsal tendons. (2/14)

Type XII collagen is a fibril-associated collagen with multiple functional domains. The purpose of this work was to determine its role in regulating tendon matrix assembly. The temporal and spatial expression patterns of both collagen and mRNA were analysed in developing chicken metatarsal tendons using immunofluorescence microscopy, in situ hybridization and real-time quantitative PCR. Temporally, type XII collagen was present during all stages of development (day 14-hatch). However, spatially, type XII collagen expression shifted from the entire tendon at day 14, when the tendon is immature and fascicles are not well developed, to the interfacial matrix (endotendinium) associated with developing fascicles. This shift was obvious beginning at day 17, becoming prominent at day 19. Associated with this shift was a gradual decrease in type XII collagen reactivity in the tendon proper (non-sheath). By hatching, the reactivity was sequestered almost exclusively to the sheaths with some reactivity remaining at the fibroblast-matrix interface within the fascicle. In situ hybridization indicated that fibroblasts in the tendon expressed type XII collagen mRNA homogeneously at day 14. However, by hatching, when the tendon matures, type XII collagen is restricted primarily to the sheath cells. Quantitative PCR analyses, of NC3 splice variants, demonstrated highest expression levels for the short splice variant mRNA at days 14-17, followed by a significant decrease at day 19 with levels remaining constant to adult. Long variant mRNA expression was highest at day 14 then decreased and was constant from day 17 to adult. These changing patterns may be related to the spatial shift in type XII collagen expression to the sheaths. Differential temporal and spatial expression patterns indicate that type XII collagen functions to integrate the developing tendon matrices and fascicles into a functional unit.  (+info)

Expression of FACIT collagens XII and XIV during bleomycin-induced pulmonary fibrosis in mice. (3/14)

Collagens XII and XIV are members of a subfamily of fibril-associated collagens with interrupted triple-helices (FACITs) that facilitate the interactions of adjacent collagen fibrils. Using immunohistochemistry and in situ hybridization, we analyzed the spatial and temporal expression pattern of collagens XII and XIV during bleomycin-induced pulmonary fibrosis. C57Bl mice were treated with bleomycin (1 U, i.p., every other day for 8 days) or saline (control), and lung tissue samples were analyzed 2-12 weeks later. Collagen I protein expression was increased in the lung 2 weeks post bleomycin treatment and persisted for at least 12 weeks. In contrast, collagen XII and XIV expression was low until 4 weeks after bleomycin treatment. Whereas collagen XII expression was greatest between 4 weeks and 8 weeks, expression of collagen XIV persisted from 4 to 12 weeks, which suggests that these two proteins may play distinct roles in the fibrotic process. The mRNA for lysyl oxidase (LOX), an enzyme for cross-linking of collagens, had a delayed increase in the lung after bleomycin administration. It reached a maximum after 8 weeks, and persisted throughout the 12 weeks of the study. These data support the hypothesis that fibrosis is a multistep process that involves both collagen accumulation and changes in the molecules that modulate the biomechanical properties of fibrils.  (+info)

Collagen XII interacts with avian tenascin-X through its NC3 domain. (4/14)

Large oligomeric proteins often contain several binding sites for different molecules and can therefore induce formation of larger protein complexes. Collagen XII, a multidomain protein with a small collagenous region, interacts with fibrillar collagens through its C-terminal region. However, no interactions to other extracellular proteins have been identified involving the non-collagenous N-terminal NC3 domain. To further elucidate the components of protein complexes present close to collagen fibrils, different extracellular matrix proteins were tested for interaction in a solid phase assay. Binding to the NC3 domain of collagen XII was found for the avian homologue of tenascin-X that in humans is linked to Ehlers-Danlos disease. The binding was further characterized by surface plasmon resonance spectroscopy and supported by immunohistochemical co-localization in chick and mouse tissue. On the ultrastructural level, detection of collagen XII and tenascin-X by immunogold labeling confirmed this finding.  (+info)

Extracellular matrix gene alternative splicing by trabecular meshwork cells in response to mechanical stretching. (5/14)

PURPOSE: Elevated intraocular pressure (IOP), sensed as mechanical stretching by trabecular meshwork (TM) cells, triggers extracellular matrix (ECM) remodeling. In addition to changes in gene expression, alternative mRNA splicing may alter ECM protein isoforms. Changes in mRNA expression and alternative splicing of four ECM molecules in response to mechanical stretching of TM cells were investigated. METHODS: Porcine TM cells were mechanically stretched for 12, 24, or 48 hours. RNA was isolated, and RT-PCR was performed with primers that flanked alternatively spliced domains. PCR products were identified by DNA sequencing. Quantitative RT-PCR (qRT-PCR) was performed with primers positioned within nonspliced and spliced regions of the genes. RESULTS: Total levels of tenascin C, collagen type XII, and CD44 mRNA were increased, whereas versican mRNA levels were decreased in response to the mechanical stretch. In addition, each of these genes expressed alternate mRNA isoforms. Transcripts containing the fibronectin type III domain D of tenascin C, the long NC3 isoform of collagen type XII, the V1 isoform of versican, and exons v7 and v8 of CD44 all increased in response to mechanical stretching. A novel isoform of collagen type XII was observed that resulted in deletion of two exons, a frameshift, and a premature stop codon. This isoform was expressed only by stretched TM cells. CONCLUSIONS: These alternative splicing events led to the modulation of potential GAG attachment sites and other ECM-binding motifs. These changes should affect TM cell-ECM and/or protein-protein interactions during the ECM remodeling that occurs coincident with homeostatic restoration of IOP to normal.  (+info)

Mechanical strain increases expression of type XII collagen in murine osteoblastic MC3T3-E1 cells. (6/14)

In adult mouse, the mRNA corresponding to the alpha1 chain of type XII collagen (alpha 1(XII)) is predominantly detected in the bone. Additionally, murine osteoblastic cells, MC3T3-E1, increased the mRNA level of alpha 1(XII) response to the mechanical strain in the stretch culture system. Cyclic stretch stress resulted in a threefold increase in mRNA level of alpha 1(XII) as compared to the control experiment in MC3T3-E1. Transient transfection assays employing a reporter construct, together with site-directed mutagenesis studies, suggested that the AP-1 binding site in the first exon of mouse alpha 1(XII) gene is important for stretch stress-mediated upregulation of alpha 1(XII) expression. Electrophoretic mobility shift assay and associated antibody supershift experiments showed that stretch stress promotes the binding of c-Jun and JunD. Further chromatin immunoprecipitation experiments confirmed the participation of these transcription factors in the region. Also, the exogenous induction of the dominant negative form of c-Jun canceled the effect of stretch stress on the stimulation of the alpha 1(XII) gene. Here, we reported a potential responsive element to the stretch stress in mouse alpha 1(XII) gene. These data will provide new information on the mechanical strain-mediated transcriptional control of alpha 1(XII)-mediated fibrillogenesis in the bone.  (+info)

Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation. (7/14)

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Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma. (8/14)

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Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Results 77 SLE and 100 controls, all female. SLE vs control group: Mean of age ys: 34 (19-49)vs 38 (19-60). Prevalence of depression: 52% (44/77) vs 29% (29/100) (p,0.05). Prevalence of fatigue (FACIT,40): 42% (33/77) and 36% (36/100) (p,0.05). Mean disease duration (months) 48 (24-114). Socio-demographic characteristics, SLICC/SLEDAI, clinical and serological manifestations were not correlated with major depression p,0.05. FACIT: Median value: 31 (range 22-40) SLE group. FACIT,22 total SLE: 12/77 (15%) and FACIT,40: 33/77 (42%). Cut points FACIT SLE vs controls: ,22: 15% (12/77) vs 1% (1/100) (p,0.05), 30% sensitivity/100% specificity, 100% PPV and 57% NPV. AUC FACIT ,22: 0.65 (0.65-0.77). FACIT,40 in SLE vs controls: 42% (33/77) vs 26% (26/100) (p,0.05), 69% sensitivity and 84% specificity, 82% PPV and 70% NPV. AUC FACIT,40: 0.75 (0.64-0.87). ...
Med facit i hand. Normalitet, elevskap och vänlig maktutövning i två svenska skolor.. Bartholdsson, Åsa. 2007. Med facit i hand. Normalitet, elevskap och vänlig maktutövning i två svenska skolor. Stockholm: Stockholms universitet. Doktorsavhandling. ...
texdoc xii work (show the pdf) No, because there is no xii*pdf in TL or CTAN. if not Id leave things as they are. Ack. I wondered about adding the new one into the existing xii package Ack. Thanks, Karl ...
Sola dosis facit venenum-thats the Latin phrase (no pun intended) representing the basic principle of toxicology. It means that a substance will produce a harmful effect on a biological system only if it accumulates above a certain concentration within the biological system. From the turf pathology perspective, the appropriate interpretation is that in order to […]. ...
Nam liber tempor cum soluta nobis eleifend option congue nihil imperdiet doming id quod mazim placerat facer possim assum. Typi non habent claritatem insitam; est usus legentis in iis qui facit eorum claritatem. Investigationes demonstraverunt lectores legere me lius quod ii legunt saepius. ...
Nam liber tempor cum soluta nobis eleifend option congue nihil imperdiet doming id quod mazim placerat facer possim assum. Typi non habent claritatem insitam; est usus legentis in iis qui facit eorum claritatem. Investigationes demonstraverunt lectores legere me lius quod ii legunt saepius.. ...
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Show moreCollagen XIV is a fibril-associated collagen with an interrupted triple helix (FACIT). Previous studies have shown that this collagen type regulates early stages of fibrillogenesis in connective tissues of high mechanical demand. Mice null for Collagen XIV are viable, however formation of the interstitial collagen network is defective in tendons and skin leading to reduced biomechanical function. The assembly of a tightly regulated collagen network is also required in the heart, not only for structural support but also for controlling cellular processes. Collagen XIV is highly expressed in the embryonic heart, notably within the cardiac interstitium of the developing myocardium, however its role has not been elucidated. To test this, we examined cardiac phenotypes in embryonic and adult mice devoid of Collagen XIV. From as early as E11.5, Col14a1(-/-) mice exhibit significant perturbations in mRNA levels of many other collagen types and remodeling enzymes (MMPs, TIMPs) within the ...
This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3 UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008 ...
Collagen, type XV, alpha 1, also known as COL15A1, is a human gene.[1] This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.[1] ...
Erico XIV (es); XIV. Erik svéd király (hu); Eiríkur 14. (is); Erik XIV.a Suediakoa (eu); Эрик XIV (ru); Erik XIV. (de); Eric XIV of Sweden (sq); Էրիկ XIV (hy); Ерик XIV (bg); Erik 14. af Sverige (da); ერიკ XIV (ka); エリク14世 (ja); اريك الاربعتاشر (arz); Ерік XIV (uk); Ericus XIV (la); Erik 14ma (io); Eerik XIV (fi); Eirikur XIV av Svøríki (fo); Eric XIV of Sweden (en-ca); Erik XIV. Švédský (cs); Erik XIV di Svezia (it); Eriko la 14-a (eo); Éric XIV de Suède (fr); Erik XIV (br); Erik XIV (et); Eric XIV of Sweden (en-gb); Erik XIV. (hr); 에리크 14세 (ko); Eric al XIV-lea al Suediei (ro); एरिक चौदावा, स्वीडन (mr); 埃里克十四世 (zh); Erik XIV của Thụy Điển (vi); Eric XIV de Suècia (ca); Erik XIV van Zweden (nl); اریک چهاردهم سوئد (fa); Ерик XIV Шведски (sr); Erik XIV van Zweden (sl); Erik XIV. (sk); Érico XIV da Suécia (pt-br); אריק הארבעה עשר, מלך ...
On Wed, 20 Dec 2017, Peter Wilson wrote: , \usr\local\texlive\2017\texmf-dist\doc\plain. I feel that the TDS should be , organized in this case so that pdftex xii will produce xii.pdf (and , similarly for xii-lat or other (La)TeX files of the same nature). Not very good idea. It would add sooooo many files to the search space, with a high probability of file name clashes etc. No, doc files will not be automatically searched by kpathsea. They (the doc files) *are* different beasts and not supposed to be input files *unless* you want to typeset the documentation. Norbert -- PREINING Norbert http://www.preining.info Accelia Inc. + JAIST + TeX Live + Debian Developer GPG: 0x860CDC13 fp: F7D8 A928 26E3 16A1 9FA0 ACF0 6CAC A448 860C DC13 ...
SOAL REMEDIAL BIOLOGI KLS XII IPA 4-6 TUGAS REMEDIAL XII IPA Kerjakan soal - soal di bawah ini sesuai dg ketentuan ! A.Soal PG da ...
VÕISTLUS: võistlus seisneb orienteerumispäevakutel osalemises. Iga liikme osaluskord suvalisel orienteerumispäevakul toob tema organisatsioonile ühe arvestuspunkti. Ühel päevakul saab üks võistleja teenida vaid ühe arvestuspunkti. Võistlus toimub organisatsioonide vahel. Suve jooksul enim arvestuspunkte kogunud organisatsioon on karikasarja võitja. Osaleja võib päevakul osaleda temale sobivas võistlusklassis, kaasa arvatud vabaklass. Arvesse lähevad 05.04.2009 kuni 10.09.2009 toimuvad päevakud ja boonusena 5.-6. juunil 2009 toimuva Kalevi Suvejooksu mõlemad päevad ning 2010 septembris toimuva XII Vironia O-päeva tulemused. Arvestusse ei lähe teised eelregistreerimisega võistlused. Eestis toimuvad päevakud on toodud EOL-i kodulehel: http://www.orienteerumine.ee/paevak/index.php ...
W: WibroTech 2008. XIV Konferencja Naukowa Wibroakustyki i Wibrotechniki. IX Og lnopolskie Seminarium Wibroakustyka w Systemach Technicznych, Krak w, 20-21 listopad 2008. Akademia G rniczo-Hutnicza w Krakowie. Katedra Mechaniki i Wibroakustyki [i in.]. Krak w : [b.w.], 2008, s. 119-120, bibliogr. 2 poz ...
Bone: Chondromyxoid fibroma, Authors: Salvatore Romeo, Pancras CW Hogendoorn. Published in: Atlas Genet Cytogenet Oncol Haematol.
Toronto, Ontario - June 7, 2012. The Ontario Institute for Cancer Research (OICR) today announced $1.5 million in funding over three years for the development of a new drug by Toronto-based Fluorinov Pharma, Inc. The drug, called FV-162, is a highly potent, orally-delivered small molecule proteasome inhibitor with significant advantages over drugs currently used to treat multiple myeloma and some forms of Non-Hodgkins lymphoma.. Our investment in Fluorinov Pharma Inc. will move FV-162 towards the market by helping it to meet the preclinical requirements of Health Canada and the FDA, said Mr. Frank Stonebanks, Vice-President, Commercialization and Chief Commercial Officer of OICR. This novel drug is very promising and could improve the quality of life and outcomes of patients with certain blood cancers.. An important target for therapies treating blood cancers such as multiple myeloma is the proteasome, a part of the cell that recycles old proteins. While effective, the current proteasome ...
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Nam liber tempor cum soluta nobis eleifend option congue nihil imperdiet doming id quod mazim placerat facer possim assum. Typi non habent claritatem insitam; est usus legentis in iis qui facit eorum claritatem. Investigationes demonstraverunt lectores legere me lius quod ii legunt saepius.. ...
Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh euismod tincidunt ut laoreet dolore magna aliquam erat volutpat. Ut wisi enim ad minim veniam, quis nostrud exerci tation ullamcorper suscipit lobortis nisl ut aliquip ex ea commodo consequat. Duis autem vel eum iriure dolor in hendrerit in vulputate velit esse molestie consequat, vel illum dolore eu feugiat nulla facilisis at vero eros et accumsan et iusto odio dignissim qui blandit praesent luptatum zzril delenit augue duis dolore te feugait nulla facilisi. Nam liber tempor cum soluta nobis eleifend option congue nihil imperdiet doming id quod mazim placerat facer possim assum.. Typi non habent claritatem insitam; est usus legentis in iis qui facit eorum claritatem. Investigationes demonstraverunt lectores legere me lius quod ii legunt saepius. Claritas est etiam processus dynamicus, qui sequitur mutationem consuetudium lectorum. Mirum est notare quam littera gothica, quam nunc putamus parum claram, anteposuerit ...
Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh euismod tincidunt ut laoreet dolore magna aliquam erat volutpat. Ut wisi enim ad minim veniam, quis nostrud exerci tation ullamcorper suscipit lobortis nisl ut aliquip ex ea commodo consequat. Duis autem vel eum iriure dolor in hendrerit in vulputate velit esse molestie consequat, vel illum dolore eu feugiat nulla facilisis at vero eros et accumsan et iusto odio dignissim qui blandit praesent luptatum zzril delenit augue duis dolore te feugait nulla facilisi. Nam liber tempor cum soluta nobis eleifend option congue nihil imperdiet doming id quod mazim placerat facer possim assum.. Typi non habent claritatem insitam; est usus legentis in iis qui facit eorum claritatem. Investigationes demonstraverunt lectores legere me lius quod ii legunt saepius. Claritas est etiam processus dynamicus, qui sequitur mutationem consuetudium lectorum. Mirum est notare quam littera gothica, quam nunc putamus parum claram, anteposuerit ...
Trappist Westvleteren 12 (XII) is a Quadrupel (Quad) style beer brewed by Brouwerij Westvleteren (Sint-Sixtusabdij van Westvleteren) in Westvleteren, Belgium. 4.6 average with 6429 ratings, reviews and opinions.
Trappist Westvleteren 12 (XII) is a Quadrupel (Quad) style beer brewed by Brouwerij Westvleteren (Sint-Sixtusabdij van Westvleteren) in Westvleteren, Belgium. 4.6 average with 6451 ratings, reviews and opinions.
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What are sports injuries in youth? Although sports injuries can range from scrapes and bruises to serious brain and spinal cord injuries, most fall somewhere between the two extremes. Here are some of the more common types of injuries: Muscle sprains and strains. Injuries of a growth plate, area of tissue at the end of the long bones in growing children and teens. Injuries from overuse of muscles and tendons. Learn more about sports injuries ...
TY - JOUR. T1 - Recurrence of chondromyxoid fibroma of great toe. AU - Mallya, P. Sharan. AU - Sujir, Premjit. PY - 2018/7/1. Y1 - 2018/7/1. N2 - Chondromyxoid fibroma (CMF) is a benign cartilaginous tumour which involves mainly the long bones and proximal tibia being common. CMF of foot and phalanx is very rare. Various treatment options are available for this tumour and recurrences have been reported following surgery. 24 year old male was treated with curettage and bone grafting for chondromyxoid fibroma of great toe 8 years back. 6 years later, he presented with local recurrence of tumour with extensive soft tissue involvement. He was treated with amputation of great toe. After two years follow up, patient was symptom free.. AB - Chondromyxoid fibroma (CMF) is a benign cartilaginous tumour which involves mainly the long bones and proximal tibia being common. CMF of foot and phalanx is very rare. Various treatment options are available for this tumour and recurrences have been reported ...
Logical Images, Inc. d/b/a VisualDx (hereinafter VisualDx, we, us, or our) has created this Acceptable Use Policy, Medical Disclaimer, & Copyright Notice (this Notice) to inform you (hereinafter you, your, or yourself) as a purchaser of a license for and/or user of the software hosted by VisualDx known as VisualDx (the Software) of certain important terms and conditions set forth in the VisualDx End User License Agreement that governs your license for and/or use of the Software (the EULA). This Notice is subject to all of the terms and conditions set forth in the EULA and does not replace or limit it in anyway. You should read the EULA in detail prior to purchasing a license for or using the Software to make sure you understand and agree to its terms and conditions. Nothing in this Notice will (a) expand your rights or VisualDx′s obligations under the EULA or (b) modify or otherwise affect any terms and conditions of the EULA or the rights of the parties under the EULA. In ...
1019 views. Kalimantan Barat - KUBU RAYA. Kepala Penerangan Komando Daerah Militer (Kapendam) XII/Tanjungpura Kolonel Infanteri Tri Rana Subekti, S.Sos, memberikan keterangan kepada awak media, bahwa sejumlah Prajurit Kodam XII/Tpr yang tergabung Pasukan Perdamaian PBB, telah kembali ke Kodam XII/Tpr, Jum`at (30/12/2016).. Kapendam XII/Tpr Kolonel Inf Tri Rana Subekti mengatakan, prajurit Kodam XII/Tpr sebanyak 18 Prajurit termasuk satu Kowad yang tergabung dalam misi Perdamaian PBB sebagai Satgas TNI Konga Unifil Lebanon, bertugas selama satu tahun telah kembali ke tanah air dengan selamat.. Perlu kita ketahui bersama, sesuai UU RI No. 34 Tahun 2004 tentang TNI disebutkan, bahwa tugas pokok TNI tersebut dilakukan dengan Operasi Militer untuk Perang (OMP) dan Operasi Militer Selain Perang (OMSP). Sedangkan OMSP sendiri salah satunya adalah melaksanakan tugas perdamaian dunia sesuai dengan kebijakan politik luar negeri, terang Kapendam XII/Tpr.. Sementara Prajurit Kodam XII/Tpr yang tergabung ...
Medical Entrance - Test Papers and notes for Class XI, Class XII, Engineering Entrance, Engineering Exam, Medical Entrance, Medical Exam, Class XI Biology, Class XII Biology covers all concepts of Nervous System, Coordination, Cell theory, Evolution, Genetics, Homeostasis, Energy,XI/XII Medical / Non-medical
Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh euismod tincidunt ut laoreet dolore magna aliquam erat volutpat. Ut wisi enim ad minim veniam, quis nostrud exerci tation ullamcorper suscipit lobortis nisl ut aliquip ex ea commodo consequat. Duis autem vel eum iriure dolor in hendrerit in vulputate velit esse molestie consequat, vel illum dolore eu feugiat nulla facilisis at vero eros et accumsan et iusto odio dignissim qui blandit praesent luptatum zzril delenit augue duis dolore te feugait nulla facilisi. Nam liber tempor cum soluta nobis eleifend option congue nihil imperdiet doming id quod mazim placerat facer possim assum.. Typi non habent claritatem insitam; est usus legentis in iis qui facit eorum claritatem. Investigationes demonstraverunt lectores legere me lius quod ii legunt saepius. Claritas est etiam processus dynamicus, qui sequitur mutationem consuetudium lectorum. Mirum est notare quam littera gothica, quam nunc putamus parum claram, anteposuerit ...
IF we examine the bright bow of Iris painted on the heavens by the sunbeams that break through the parting storm-clouds, no matter how closely we may scan it, we shall not be able to determine where the colors begin or end. As in this arch the blue gradually passes over into a green, and the green in turn changes insensibly into a yellow, even thus we find, in the countless forms in which Nature delights, the most delicate gradations, the most gradual transitions. Natura non facit saltus: this saying of Linnés is realized everywhere in the ever-changeful realm of life.. How difficult a matter it is to decide whether the lung-fish of Brazil and Senegambia belong to the amphibia or to the fishes, which in other instances are known to always breathe by their gills! In the rainless season of the year the swamps, the homes of these animals, dry out; they then coat themselves with a crust of earth, and are dependent on their lungs for every breath they draw. During the rest of the year they can use ...
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No-ti-ce is gi-ven in terms of Re-gu-la-ti-ons pu-blis-hed in Go-vern-ment No-ti-ce No R.324, 325, 326, and 327, ac-cor-ding to C-hap-ter 5 of the Na-ti-o-nal En-vi-ron-men-tal Ma-na-ge-ment Act (Act 107 of 1998) of the ap-pli-ca-ti-on for an EIA Ba-sic As-ses-sment Aut-ho-ri-sa-ti-on, which will be sub-mit-ted to Eastern Ca-pe Pro-vin-ces De-part-ment of E-co-no-mic De-ve-lop-ment, En-vi-ron-men-tal Af-fairs & Tou-rism for the pur-po-se of:. • Pro-po-sed chan-ge of lan-du-se to In-s-ti-tu-ti-o-nal I and II for hos-pi-tal, Re-si-den-ti-al II and IV, Con-sent for Re-ti-re-ment Pur-po-ses, and as-so-ci-a-ted In-fra-struc-tu-re:. GN 327 Lis-ting 1, Acti-vi-ty 12 The de-ve-lop-ment of (vi) bulk storm-wa-ter out-let struc-tu-res ex-cee-ding 100 sqm in si-ze, (x) buil-dings ex-cee-ding 100 sqm in si-ze, and (xii) in-fra-struc-tu-re or struc-tu-res with a phy-si-cal foot-print of 100 sqm or mo-re (c) within 32m from a wa-ter-cour-se.. GN 327 Lis-ting 1, Acti-vi-ty 27 The cle-a-ran-ce of an a-rea of ...
Purpose: Oncogene mutations contribute to colorectal cancer development. We searched for differences in oncogene mutation profiles between colorectal cancer metastases from different sites and evaluated these as markers for site of relapse. Experimental Design: One-hundred colorectal cancer metastases were screened for mutations in 19 oncogenes, and further 61 metastases and 87 matched primary cancers were analyzed for genes with identified mutations. Mutation prevalence was compared between (a) metastases from liver (n=65), lung (n=50) and brain (n=46), (b) metastases and matched primary cancers, and (c) metastases and an independent cohort of primary cancers (n=604). Mutations differing between metastasis sites were evaluated as markers for site of relapse in 859 patients from the VICTOR trial. Results: In colorectal cancer metastases, mutations were detected in 4 of 19 oncogenes: BRAF (3.1%), KRAS (48.4%), NRAS (6.2%) and PIK3CA (16.1%). KRAS mutation prevalence was significantly higher in ...
Conclusion. Results of our study show that synchronous hepatic metastases of colorectal cancers are less frequently observed in chronic HBV or HCV infected patients than in non infected patients, while the incidence of extrahepatic metastases is comparable in both groups, suggesting that virus-related mechanisms and specific liver mediated immunity may have a protective role against neoplastic cell colonization of the liver.. ...
Nostrud exerci tation ullamcorper suscipit lobortis nisl ut aliquip ex ea commodo consequat. Duis autem vel eum iriure dolor in hendrerit in vulputate velit esse molestie consequat, vel illum dolore eu feugiat nulla facilisis at vero eros et accumsan et iusto odio dignissim qui blandit praesent luptatum zzril delenit augue duis dolore te feugait nulla facilisi. lacerat facer possim assum. Typi non habent claritatem insitam; est usus legentis in iis qui facit eorum claritatem. Investigationes demonstraverunt lectores legere me lius quod ii legunt saepius vel illum dolore eu feugiat nulla facilisis at vero eros et accumsan. Ex ea commodo consequat. Duis autem vel eum iriure dolor in hendrerit in vulputate velit esse molestie consequat, vel illum dolore eu feugiat nulla facilisis at vero eros et accumsan et iusto odio dignissim qui blandit praesent luptatum zzril delenit augue duis dolore te feugait nulla facilisi. Nam liber tempor cum soluta nobis eleifend option congue nihil imperdiet doming id ...
Nostrud exerci tation ullamcorper suscipit lobortis nisl ut aliquip ex ea commodo consequat. Duis autem vel eum iriure dolor in hendrerit in vulputate velit esse molestie consequat, vel illum dolore eu feugiat nulla facilisis at ver nulla facilisi. lacerat facer possim assum. Typi non habent claritatem insitam; est usus legentis in iis qui facit eor um claritatem. Investigationes demonstraverunt lectores legere me lius quod ii legunt saepius vel illum dolore eu feugiat nulla facilisis at vero eros et accumsan etpraesent.. ...
Lorem ipsum dolor sit amet, consectetuer adipiscing elit, sed diam nonummy nibh euismod tincidunt ut laoreet dolore magna aliquam erat volutpat. Ut wisi enim ad minim veniam, quis nostrud exerci tation ullamcorper suscipit lobortis nisl ut aliquip ex ea commodo consequat. Duis autem vel eum iriure dolor in hendrerit in vulputate velit esse molestie consequat, vel illum dolore eu feugiat nulla facilisis at vero eros et accumsan et iusto odio dignissim qui blandit praesent luptatum zzril delenit augue duis dolore te feugait nulla facilisi.. Nam liber tempor cum soluta nobis eleifend option congue nihil imperdiet doming id quod mazim placerat facer possim assum. Typi non habent claritatem insitam; est usus legentis in iis qui facit eorum claritatem. Investigationes demonstraverunt lectores legere me lius quod ii legunt saepius. Claritas est etiam processus dynamicus, qui sequitur mutationem consuetudium lectorum. Mirum est notare quam littera gothica, quam nunc putamus parum claram, anteposuerit ...
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Rudolf Steiner Archive: Gospel of St. John: Lecture XII - The decline of the ancient wisdom and its renewal through the Christ-impulse. The significance of the Mystery of Golgotha for human evolution upon earth.
The real challenge to come is to acquire SIM cards for our data dongles in order to avoid the rip-off rates charged for data roaming. It will be interesting to see whether the various French telcos and mobile operators still persist in their bizarre policy of allowing you to top up your account in a shop using a credit card but will not allow you to use the same card for the same purpose on-line (unless its a French card of course). Perhaps M. Hollande will sort it out when hes finished dealing with Angela ...
Chondromyxoid fibroma is a rare benign tumor of cartilaginous origin with myxoid and fibrous components. It accounts for approximately 1% of bone tumors. Metaphysis of long bones is the most common location of this tumor. However, there a few case reports of this tumor arising from epiphysis of short tubular bones of the hand and feet. An 11-year-old girl presented to our OPD with complaints of pain and a gradually progressive swelling of the right great toe. On examination, the swelling was diffuse with no signs of inflammation. X-ray examination revealed a well-defined, longitudinally oval lytic lesion in the right distal phalanx of great toe, involving the growth plate and, eroding the medial cortex. Computed tomography (CT) scan did not show any evidence of calcification, septations or involvement of soft tissue. Open biopsy and curettage was done and the specimen was sent for histopathological examination. Histopathological examination (HPE) showed a lobular pattern consisting of myxomatous
UniProtKB/Swiss-Prot : 74 Osteogenesis imperfecta 12: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI12 is an autosomal recessive form characterized by recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae ...
Looking for online definition of Ehlers-Danlos-like syndrome due to tenascin-X deficiency in the Medical Dictionary? Ehlers-Danlos-like syndrome due to tenascin-X deficiency explanation free. What is Ehlers-Danlos-like syndrome due to tenascin-X deficiency? Meaning of Ehlers-Danlos-like syndrome due to tenascin-X deficiency medical term. What does Ehlers-Danlos-like syndrome due to tenascin-X deficiency mean?
Gut vascular barrier impairment leads to intestinal bacteria dissemination and colorectal cancer metastasis to liver / A. Bertocchi, S. Carloni, P.S. Ravenda, G. Bertalot, I. Spadoni, A. Lo Cascio, S. Gandini, M. Lizier, D. Braga, F. Asnicar, N. Segata, C. Klaver, P. Brescia, E. Rossi, A. Anselmo, S. Guglietta, A. Maroli, P. Spaggiari, N. Tarazona, A. Cervantes, S. Marsoni, L. Lazzari, M.G. Jodice, C. Luise, M. Erreni, S. Pece, P.P. Di Fiore, G. Viale, A. Spinelli, C. Pozzi, G. Penna, M. Rescigno. - In: CANCER CELL. - ISSN 1535-6108. - 39:5(2021 May 10), pp. 708-724.e11 ...
α). With acc.: ut faber, cum quid aedificaturus est, non ipse facit materiam, sed ea utitur, quae sit parata, etc. ... Quod si non est a deo materia facta, ne terra quidem et aqua et aër et ignis a deo factus est, Cic. N. D. Fragm. ap. Lact. 2, 8 (Cic. ed. Bait. 7, p. 121): sphaera ab Archimede facta, Cic. Rep. 1, 14: fecitque idem et sepsit de manubiis comitium et curiam, id. ib. 2, 17: aedem, id. ib. 2, 20: pontem in Arari faciundum curat, Caes. B. G. 1, 13, 1: castra, id. ib. 1, 48, 2; Cic. Fam. 15, 4, 4: faber vasculum fecit, Quint. 7, 10, 9: classem, Caes. B. G. 4, 21, 4: cenas et facere et obire, Cic. Att. 9, 13, 6: ignem lignis viridibus, Cic. Verr. 2, 1, 17, § 45: poëma, to compose, id. Pis. 29, 70: carmina, Juv. 7, 28: versus, id. 7, 38: sermonem, Cic. Fam. 9, 8, 1; cf. litteram, id. Ac. 2, 2, 6: ludos, to celebrate, exhibit = edere, id. Rep. 2, 20; id. Att. 15, 10; also i. q. ludificari, Plaut. Capt. 3, 4, 47: sementes, i. e. to sow, Caes. B. G. 1, ...
That in order to enforce this Order and responsibility, I, Kevin Annett Eagle Strong Voice, will publicly deputize any and all members of the Vancouver police department and the RCMP to enforce this legal order, as is their duty and obligation under common law, and that any refusal by them to do so, or any attempt by them to prevent me or my agents from enforcing this Order, will be considered an act of hostile intent and criminality by them, and a violation of their oath of office. In the event of such a dereliction of duty on the part of these police officers, I reserve my right under common law and Siem Kiapilanos original authorization to appoint Public Peace Officers to maintain the peace and enforce this lawful Order according to the principle Actus legis nemini facit injuriam, The act of the law does no one an injury ...
Typi non habent claritatem insitam; est usus legentis in iis qui facit eorum claritatem. Investigationes demonstraverunt lectores legere me lius quod ii legunt saepius. Claritas est etiam processus dynamicus, qui sequitur mutationem consuetudium lectorum.. Mirum est notare quam littera gothica, quam nunc putamus parum claram, anteposuerit litterarum formas humanitatis per seacula quarta decima et quinta decima. Eodem modo typi, qui nunc nobis videntur parum clari, fiant sollemnes in futurum.. Claritas est etiam processus dynamicus, qui sequitur mutationem consuetudium lectorum. Mirum est notare quam littera gothica, quam nunc putamus parum claram, anteposuerit litterarum formas humanitatis per seacula quarta decima et quinta decima. Eodem modo typi, qui nunc nobis videntur parum clari, fiant sollemnes in futurum ...
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Factor XII Genetically Deficient (Knockout) Products are applicable to a wide range of in vitro research applications (including ELISA and Western Blot) and for many different areas of research, including cardiovascular and neurological studies. Our Factor XII Knockout was created by targeted disruption of the F12 gene
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Pubblicazioni scientifiche svolte dallIstituto Pio XII: asma allergico, bronchite asmatica allergica, asma da sforrzo, tosse allergica, terapie e sintomi asma
... contains type I collagen and type XII collagen. Michael H. Ross. Histology: A Text and Atlas, with Correlated ... Perichondrium is a type of irregular collagenous ordinary connective tissue, and also functions in the growth and repair of ... Biosynthesis and Gene Regulation of Collagens in Cartilage and Bone", Dynamics of Bone and Cartilage Metabolism (Second Edition ... 3-40, doi:10.1016/b978-012088562-6/50002-9, ISBN 978-0-12-088562-6, retrieved 2020-11-18 Iowa Histology Index 4/iv-05 - "Slide ...
Found to have type I, III, VI, and XII collagen. Connective tissue in skeletal muscle Endomysium Epimysium E. Passerieux, R. ... The overall comprehensive organization of the perimysium collagen network, as well as its continuity and disparateness, however ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... Collagen, type I, alpha 1 (COL1A1) Collagen, type II, alpha 1 (COL2A1) Collagen, type III, alpha 1 (COL3A1) Collagen, type V, ... collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of VWA-containing proteins are ... "Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins". ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of vWA-containing proteins are ... Colombatti A, Bonaldo P, Doliana R (1993). "Type A modules: interacting domains found in several non-fibrillar collagens and in ... This type A domain is the prototype for a protein superfamily (InterPro: IPR036465; see also Pfam clan). The vWA domain is ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... Von Willebrand factor type D domain (vWD) is an evolutionarilly-conserved protein domain found in, among others, the von ... "The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform ... Willebrand factor (vWF). vWF is a large multimeric glycoprotein and it is synthesized by a type of bone marrow cell called ...
Type II domains have also been found in a range of proteins including blood coagulation factor XII; bovine seminal plasma ... Fibronectin type II domain is a collagen-binding protein domain. Fibronectin is a multi-domain glycoprotein, found in a soluble ... Fibronectin type-II collagen-binding domain in PROSITE v t e. ... which are called type I, II, and III. Type II domain is ... contains four conserved cysteines involved in disulfide bonds and is part of the collagen-binding region of fibronectin. Type ...
The COL2A1 gene results in malformed type II collagen, which is essential in the transition from collagen to bone. This is the ... The COL2A1 gene is responsible for producing type II collagen. The mutation of COL2A1 gene leads to abnormal skeletal growth ... Hypochondrogenesis is caused when type II collagen is abnormally formed due to a mutation in the COL2A1 gene. Normally, the ... or metatrophic dwarfism type II. Because collagen plays an important role in the development of the body, people with Kniest ...
XII, XIV) Short chain (Type VIII, X) Basement membrane (Type IV) Other (Type VI, VII, XIII) Elastins, in contrast to collagens ... Each type of connective tissue in animals has a type of ECM: collagen fibers and bone mineral comprise the ECM of bone tissue; ... The collagen can be divided into several families according to the types of structure they form: Fibrillar (Type I, II, III, V ... Laminins bind other ECM components such as collagens and nidogens. There are many cell types that contribute to the development ...
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C- ... Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen".[citation needed] Collagen IV ... type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 ... Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase?". Alcoholism: ...
This gene is in between COL2A1, the human type II collagen gene, and VDR, the human Vitamin D Receptor gene. This protein is ... It can be found expressed in many tissues types. Tissue types with high expression included the adrenal gland, eye, ... Krogh, Anders (12 Jun 2013). "TMHMM Server v 2.0". Tusnady, G.E. (2001). "HMMTop: Prediction of transmembrane helices and ... This gene spans from 48357225 to 48362667 on chromosome 12. ...
The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in ... and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII". The Journal of ... Lauer-Fields JL, Tuzinski KA, Shimokawa K, Nagase H, Fields GB (May 2000). "Hydrolysis of triple-helical collagen peptide ... During embryonic development, MMP13 is expressed in the skeleton as required for restructuring the collagen matrix for bone ...
Fibril Associated Collagens with Interrupted Triple Helices) (Type IX, XII, XIV, XIX, XXI) Short chain (Type VIII, X) Basement ... Over 90% of the collagen in the human body is type I collagen. However, as of 2011, 28 types of collagen have been identified, ... Type XIII, XVII) Microfibril forming (Type VI) Anchoring fibrils (Type VII) The five most common types are: Type I: skin, ... With type I collagen and possibly all fibrillar collagens, if not all collagens, each triple-helix associates into a right- ...
... collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) CRACR2A: encoding protein Calcium ... achondrogenesis type 2 collagenopathy, types II and XI cornea plana 2 episodic ataxia hereditary hemorrhagic telangiectasia ... cblB type MON2: encoding protein Protein MON2 homolog MUCL1: encoding protein Mucin-like protein 1 MYO1A: myosin IA NANOG: NK-2 ... type II, gamma PIWIL1: encoding protein Piwi-like protein 1 POP5: encoding enzyme Ribonuclease P/MRP protein subunit POP5 ...
Collagen, type I, alpha 1 Collagen, type II, alpha 1 Collagen, type III, alpha 1 Collagen, type IV, alpha 1 Collagen, type V, ... type VI, alpha 1 Collagen, type VII, alpha 1 Collagen, type VIII, alpha 1 Collagen, type IX, alpha 1 Collagen, type X, alpha 1 ... collagen (type I, II, VI, X collagen fibrils) and proteoglycans. The ratio and the proportion of collagen play an important ... "Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen". Cell and ...
... is a type of collagen which is also a proteoglycan. FACIT collagens include collagen types IX, XII, XIV, XIX, and XXI. COL22A1 ... GO term: FACIT collagen[permanent dead link] "FACIT - Collagens which are proteoglycnas". Archived from the original on 2006-10 ... Tuckwell D (2002). "Identification and analysis of collagen alpha 1(XXI), a novel member of the FACIT collagen family". Matrix ... FACIT collagen (Fibril Associated Collagens with Interrupted Triple helices) ...
Each capsule is about 1 mm long, has a diameter of about 0.1 mm, and is perforated by one or more afferent type Ib sensory ... The body of the organ is made up of braided strands of collagen (intrafusal fasciculi) that are less compact than elsewhere in ... Inside the capsule, the afferent fibers lose their medullary sheaths, branch, intertwine with the collagen fibers, and ... terminate as flattened leaf-like endings between the collagen strands (see figure). When the muscle generates force, the ...
Collagenopathy, types II and XI XII. FACIT collagen, interacts with type I containing fibrils, decorin and glycosaminoglycans. ... TypesEdit. Collagen occurs in many places throughout the body. Over 90% of the collagen in the human body, however, is type I.[ ... Multiple collagen fibrils form into collagen fibers.. *Collagen may be attached to cell membranes via several types of protein ... With type I collagen and possibly all fibrillar collagens, if not all collagens, each triple-helix associates into a right- ...
Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. ... "Entrez Gene: COL9A3 collagen, type IX, alpha 3". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...
Type XV collagen is known to be a tumor suppressor that can be used to understand tumor cells environment. Type XV collagen ... This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with ... "Entrez Gene: COL15A1 collagen, type XV, alpha 1". "Collagen XV, a multifaceted multiplexin present across tissues and species ... "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed ...
Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, a collagen component of hyaline cartilage. ... "Entrez Gene: COL9A1 collagen, type IX, alpha 1". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...
... type III collagen is also an important regulator of the diameter of type I and II collagen fibrils. Type III collagen is also ... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... Type III collagen could also be important in several other human diseases. Increased amounts of type III collagen are found in ... Type III collagen is one of the fibrillar collagens whose proteins have a long, inflexible, triple-helical domain. Type III ...
... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. ... the structure of type I collagen is compromised. Tissues that are rich in type I collagen, such as the skin, bones, and tendons ... Ehlers-Danlos type IV is most attributed to abnormalities in the reticular fibers (collagen Type III). Ehlers-Danlos syndrome, ...
... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ... "Entrez Gene: COL5A3 collagen, type V, alpha 3". van der Rest M, Garrone R (1991). "Collagen family of proteins". FASEB J. 5 (13 ...
This protein is an alpha chain of type VI collagen that aids in microfibril formation. As part of type VI collagen, this ... This gene encodes the alpha 3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in ... "The 1.6 A structure of Kunitz-type domain from the alpha 3 chain of human type VI collagen". Journal of Molecular Biology. 246 ... "Anisotropic behaviour of the C-terminal Kunitz-type domain of the alpha3 chain of human type VI collagen at atomic resolution ( ...
... chain of type II collagen. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and ... "A COL2A1 mutation in achondrogenesis type II results in the replacement of type II collagen by type I and III collagens in ... type 2 by affecting tissues that are rich in type II collagen. Platyspondylic lethal skeletal dysplasia, Torrance type:Fewer ... chain that cannot be incorporated into type II collagen fibers. As a result, cells make a reduced amount of type II collagen. ...
XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". ... This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with ... other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve ... "Entrez Gene: COL19A1 collagen, type XIX, alpha 1". Yoshioka H, Zhang H, Ramirez F, et al. (1992). "Synteny between the loci for ...
2005). "Collagen types XII and XIV are present in basement membrane zones during human embryonic development". J. Mol. Histol. ... Tono-Oka S, Tanase S, Miike T, Tanaka H (1996). "Transient expression of collagen type XIV during muscle development and its ... Collagen alpha-1(XIV) chain is a protein that in humans is encoded by the COL14A1 gene. It likely plays a role in collagen ... Bauer M, Dieterich W, Ehnis T, Schuppan D (Jan 1998). "Complete primary structure of human collagen type XIV (undulin)". ...
It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of the type IV collagen and plays a role in ... collagen". FEBS Letters. 225 (1-2): 188-94. doi:10.1016/0014-5793(87)81155-9. PMID 3691802. "Entrez Gene: COL4A1 collagen, type ... Type IV collagen is the major structural component of basement membranes, which contains two or three COL4A1 proteins. Thus, ... COL4A1 belongs to the type IV collagen family and contains three domains: a short N-terminal domain, a long triple-helical 7S ...
Atrophic acne scars have lost collagen from the healing response and are the most common type of acne scar (account for ... acne generally improves between eight and twelve weeks after starting therapy.[15] ... microspheres with collagen; human and bovine collagen derivatives, and fat harvested from the person's own body (autologous fat ... Many over-the-counter treatments in many forms are available, which are often known as cosmeceuticals.[168] Certain types of ...
List of human cell types derived from the germ layers. References[edit]. *^ .mw-parser-output cite.citation{font-style:inherit ... The disease has symptoms similar to those resulting from Trsp gene knockout.[12] ... COL2A1 collagen disease. *Achondrogenesis *type 2. *Hypochondrogenesis. SLC26A2 sulfation defect. *Achondrogenesis *type 1B ... 40 (12): 2710-2738. doi:10.1016/j.biocel.2008.05.011. PMC 4427832. PMID 18620888.. ...
The dissolution of collagen depends on time, temperature and environmental pH.[8] At high temperatures, the rate of collagen ... The study of diagenesis in rocks is used to understand the geologic history they have undergone and the nature and type of ... The composite nature of bone, comprising one-third organic (mainly protein collagen) and two thirds mineral (calcium phosphate ... The hydrolytic activity plays a key role in the mineral phase transformations that exposes the collagen to accelerated chemical ...
Type I collagen is present in many forms of connective tissue, and makes up about 25% of the total protein content of the ... Type I Collagen". Journal of Biological Chemistry. 277 (6): 4223-31. doi:10.1074/jbc.M110709200. PMID 11704682.. ... TypesEdit. Connective tissue can be broadly subdivided into connective tissue proper, and special connective tissue.[5][6] ... groups of adipose cells are kept together by collagen fibers and collagen sheets in order to keep fat tissue under compression ...
Research has shown that scores below twelve indicate color vision deficiency, and twelve or more correct indicate normal color ... Diagnostic plates: intended to determine the type of color vision defect (protanopia or deuteranopia) and the severity of it. ... Corneal collagen cross-linking. Iris, ciliary body,. sclera, and anterior chamber. *Glaucoma surgery: Trabeculectomy ... Demonstration plate (plate number one, typically the numeral "12"); designed to be visible by all persons, whether normal or ...
10% of all dislocations are anterior and this is broken down into superior and inferior types.[32] Superior dislocations ... syndrome is genetically inherited disorder that is thought to affect the encoding of the connective tissue protein's collagen ... the most common type of shoulder dislocation (96-98% of the time) occurs when the arm is in external rotation and abduction ( ... 12(5): 413-415. *^ Cools, Ann M.; Borms, Dorien; Castelein, Birgit; Vanderstukken, Fran; Johansson, Fredrik R. (2016-02-01). " ...
Both types of plants occur in tropical areas, but only C3 plants occur naturally in colder areas. 12C and 13C occur in a ratio ... Nitrogen isotopes in bone collagen are ultimately derived from dietary protein, while carbon can be contributed by protein, ... This references the variety of types of labor (e.g., domestic vs. carrying heavy loads) labor that enslaved individuals were ... Many methods tracking these types of changes have been developed using a variety of skeletal series. For instance, in children ...
Possibly important to basement membrane architecture and tissue development, as a needed catalyst to make collagen IV.[37] ... "Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture". Cell. 157 ... Required in the synthesis of vitamin B12, but because bacteria are required to synthesize the vitamin, it is usually considered ... vitamin B12) by bacteria. Minerals are used by animals and microorganisms for the process of mineralizing structures, called " ...
Data also proposed a decrease in weight gain as a result of increased consumption lessens the risk of developing diabetes type ... Foundation for strong healthy bones and teeth - majority of the calcium consumed as a child is deposited onto collagen bone ... Vitamin A ensures sufficient collagen is produced to build strong healthy bones and other connecting tissues (Deen & Hark, 2007 ... A 2007 study by Boeing et al., explored common chronic lifestyle diseases including diabetes type 2 mellitus, obesity, ...
Based on this, eight types of secondary structure are assigned. The 310 helix, α helix and π helix have symbols G, H and I and ... Two types of beta sheet structures exist; a beta bridge has symbol B while longer sets of hydrogen bonds and beta bulges have ... is at least 70°), and a blank (or space) is used if no other rule applies, referring to loops.[3] These eight types are usually ...
Type. Appearance (micrograph). Appearance (illustration). Approx. %. in adults. See also:. Blood values. Diameter (μm)[7]. Main ... It rises in response to allergies, parasitic infections, collagen diseases, and disease of the spleen and central nervous ... This type of white blood cell decreased is usually the neutrophil. In this case the decrease may be called neutropenia or ... Types of white blood cells can be classified in standard ways. Two pairs of broadest categories classify them either by ...
There are two types of alveolar epithelial cells - Type 1 pneumocytes represent 90% of the cell surface area, and are easily ... Mice that survive this initial onslaught go on to demonstrate an increase in lung collagen content, and decreased lung ... Type 2 pneumocytes are more resistant to damage, which is important as these cells produce surfactant, transport ions and ... Depending on the type and amount of irritant gas inhaled, victims can experience symptoms ranging from minor respiratory ...
... of which is collagen type 1 and the remaining 10% ground substance, which includes dentine-specific proteins), and 10% water ( ... TypesEdit. There are three types of dentin, primary, secondary and tertiary.[13][14] Secondary dentin is a layer of dentin ... It is of two types, either reactionary, where dentin is formed from a pre-existing odontoblast, or reparative, where newly ... It is unmineralized and consists of collagen, glycoproteins and proteoglycans. It is similar to osteoid in bone and is thickest ...
Types[edit]. General[edit]. Irwin Fridovich and Joe McCord at Duke University discovered the enzymatic activity of superoxide ... insights into heparin and collagen binding". J. Mol. Biol. 388 (2): 310-26. doi:10.1016/j.jmb.2009.03.026. PMID 19289127.. ... Fe and Mn types (which bind either iron or manganese), and the Ni type (which binds nickel). ... In wild-type S. cerevisiae, DNA damage rates increased 3-fold with age, but more than 5-fold in mutants deleted for either the ...
collagen trimer. • proteinaceous extracellular matrix. • extracellular region. • extracellular exosome. • extracellular space. ...
... as healthy collagen replaces the defective collagen with vitamin C repletion. Treatment can be orally or by intramuscular or ... Yamada H, Yamada K, Waki M, Umegaki K (October 2004). "Lymphocyte and plasma vitamin C levels in type 2 diabetic patients with ... including wound healing and collagen synthesis. In humans, vitamin C deficiency leads to impaired collagen synthesis, ... Hydroxylation allows the collagen molecule to assume its triple helix structure, and thus vitamin C is essential to the ...
Work at the Institute for Cell Biology, University of Bonn, showed that a certain type of autophagy, i.e., chaperone-assisted ... Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... 12: 9-14. doi:10.1038/nrm3028.. *^ a b Levine B, Mizushima N, Virgin HW (January 2011). "Autophagy in immunity and inflammation ... 112 (12): 1809-20. doi:10.1172/JCI20039. PMC 297002 . PMID 14638851.. *^ Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, ...
Two types of PDGFRs have been identified: alpha-type and beta-type PDGFRs.[8] The alpha type binds to PDGF-AA, PDGF-BB and PDGF ... The addition of PDGF at specific time‐points has been shown to stabilise vasculature in collagen‐glycosaminoglycan scaffolds.[ ... Types and classification[edit]. There are five different isoforms of PDGF that activate cellular response through two different ... The receptor for PDGF, PDGFR is classified as a receptor tyrosine kinase (RTK), a type of cell surface receptor. ...
The three main types of hyaluronidases are two classes of eukaryotic endoglycosidase hydrolases and a prokaryotic lyase-type of ... "Testicular hyaluronidase induces tubular structures of endothelial cells grown in three-dimensional collagen gel through a CD44 ... "September 12, 2004 Approval Letter". FDA. FDA.gov. Retrieved 20 November 2015.. ... 12] bladder, prostate, breast and brain), whereas low expression of HYAL1 is correlated with a decrease in survival of ...
TNF can bind two receptors, TNFR1 (TNF receptor type 1; CD120a; p55/60) and TNFR2 (TNF receptor type 2; CD120b; p75/80). TNFR1 ... Tumor necrosis factor (TNF) alpha increases collagen accuulation and proliferation in intestinal myofibrobasts via TNF Receptor ... TNF is primarily produced as a 233-amino acid-long type II transmembrane protein arranged in stable homotrimers.[24][25] From ... TNF was thought to be produced primarily by macrophages,[36] but it is produced also by a broad variety of cell types including ...
Work at the Institute for Cell Biology, University of Bonn, showed that a certain type of autophagy, i.e., chaperone-assisted ... Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... There are three main types of autophagy (macroautophagy, microautophagy and Chaperone mediated autophagy), these are mediated ... 112 (12): 1809-20. doi:10.1172/JCI20039. PMC 297002. PMID 14638851.. *^ Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, ...
... that is caused by a mutation in one of the three genes coding for type VI collagen.[2] These include COL6A1, COL6A2, and COL6A3 ... Okada M et al (2007) Primary collagen VI deficiency is the second most common congenital muscular dystrophy in Japan. Neurolog ... "Collagen VI related muscle disorders" (PDF). J. Med. Genet. 42 (9): 673-85. doi:10.1136/jmg.2002.002311. PMC 1736127 . PMID ...
Possibly collagen and/or citrullinated self proteins. Chronic arthritis, inflammation, destruction of articular cartilage and ... Type V hypersensitivity. References[edit]. *^ a b c d e f g Kumar, Vinay; Abbas, Abul K.; Aster, Jon C. (2012-05-01). Robbins ... Type 4 hypersensitivity is often called delayed type hypersensitivity as the reaction takes several days to develop. Unlike the ... Diabetes mellitus type 1[1]. Pancreatic beta cell proteins (possibly insulin, glutamate decarboxylase). Insulitis, beta cell ...
Collagen cross-linking by applying riboflavin topically then shining UV light is a method to slow progression of corneal ... One such organism is Micrococcus luteus (American Type Culture Collection strain number ATCC 49442), which develops a yellow ... Archived from the original on 2016-12-30.. *^ a b "Office of Dietary Supplements - Riboflavin". ods.od.nih.gov. 11 February ... Archived from the original on 2016-12-30.. *^ "WHO Model List of Essential Medicines (19th List)" (PDF). World Health ...
Platelet activation (through agonists such as thrombin, Type II collagen and ADP) results in "membrane flipping" where the ... The extracellular region of P-selectin is composed of three different domains like other selectin types; a C-type lectin-like ... a type of glycosaminoglycan (GAG). Its activity in tumor metastasis has been probed by the addition of heparin that functions ... The number of CRP repeats is the major feature differentiating the type of selectin in extracellular region. In human, P- ...
ANA type. Target antigen. Sensitivity (%) SLE. Drug-induced LE. Diffuse systemic sclerosis. Limited systemic scleroderma. ... collagen IV, fibronectin and laminin. Binding to these antigens within the kidney could cause inflammation and complement ... Some ANAs appear in several types of disease, resulting in lower specificity of the test. For example, IgM-rheumatoid factor ( ... Type I topoisomerase -[62]. -[62]. 20[62]. 10[62]. -[62]. -. -[62] Anti-centromere Centromeric proteins -[62]. -[62]. 30[62]. ...
"Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen" ... 12]:171 இவை பெரிய குருதிக்குழல் சுவர்களிலும் தசைநார்களிலும் குறிப்பாக மஞ்சள் தசைநாரிலும் காணப்படுகின்றன.[12]:173 ... இவை தொடக்கநிலை அழற்சி, நோயெதிர்ப்பு சார்ந்த துலங்கலை, எதிர்ப்பொருள்களைச் சந்திக்கும்போது உருவாக்குகின்றன.[12]:161 நோய்நாடல் ... இது கொப்பூழ்கொடியில் அல்லது தொப்புள் கொடியில் காணப்படுகிறது.[12]:160 பல்வேறுவகை சிறப்பு இழையங்களும்
July 2002). "D-Amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the ... "Extraction and identification of collagen-derived peptides with hematopoietic activity from Colla Corii Asini". Journal of ... B-type Natriuretic Peptide (BNP) - produced in myocardium & useful in medical diagnosis ... 31 (6): 605-12. doi:10.1002/bip.360310604. PMID 1932561.. CS1 maint: Multiple names: authors list (link) ...
The errors are of four general types: *Variations in the 14. C/12. C ratio in the atmosphere, both geographically and over time ... as well as for different parts of animals such as bone collagen, but when dating a given sample it is better to determine the δ ... 12. ). sample. (. C. 13. C. 12. ). PDB. −. 1. ). ×. 1000. {\displaystyle {\ce {\delta ^{13}C}}=\left({\frac {\left({\frac {{\ce ... C/12. C ratio is used because it is much easier to measure than the 14. C/12. C ratio, and the 14. C/12. C ratio can be easily ...
... collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to ... type XII, alpha 1". Oh SP, Taylor RW, Gerecke DR, et al. (1992). "The mouse alpha 1(XII) and human alpha 1(XII)-like collagen ... This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted ... XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". ...
Collagen degradation (Homo sapiens) * Collagen type XII degradation by MMP12 (Homo sapiens) * Cleaved collagen type XII [ ... Cleaved collagen type XII [extracellular region] (Danio rerio) Cleaved collagen type XII [extracellular region] (Gallus gallus) ... Cleaved collagen type XII [extracellular region] (Bos taurus) Cleaved collagen type XII [extracellular region] (Canis ... Cleaved collagen type XII [extracellular region] (Mus musculus) Cleaved collagen type XII [extracellular region] (Rattus ...
Cellular and humoral anti-collagen immune mechanisms appear to be involved in the pathogenesis of arthriti … ... A destructive joint disease can be induced in susceptible DBA/1 mice by immunization with type II collagen emulsified with oil ... and either killed Mycobacterium tuberculosis or IL-12 as adjuvant. ... A destructive joint disease can be induced in susceptible DBA/1 mice by immunization with type II collagen emulsified with oil ...
Collagen types XII and XIV belong to a subgroup of... ... The collagens constitute a large group of proteins in the ... Collagen types XII and XIV belong to a subgroup of non-fibrillar-collagens termed (fibril-associated collagens with interrupted ... collagen type-XII was present in the basement membrane zones of epithelia and endothelia. However, collagen type-XIV was ... RE 1991Two type XII-like collagens localize to the surface of banded collagen fibrilsJ Cell Biol113971978Google Scholar ...
... type XII collagen could be associated with a disorganized collagen fiber arrangement. 22 Thus, type XII collagen could also ... Recently, using type XII collagen-null mice, it was demonstrated that type XII collagen could be involved in bone formation and ... Unwounded cornea expressed a low level of type XII collagen (Fig. 7B). At D7 after injury, type XII collagen staining was ... The next steps will concern the functional analysis of type XII collagen using mice deficient for collagen XII. Targeting type ...
Type XII and XIV collagens associate with type I and type II fibrils. (Homo sapiens) * Collagen type I,II:XII,XIV fibrils [ ... Collagen type XII, XIV fibrils [extracellular region] (Homo sapiens) * Collagen type XII fibril [extracellular region] (Homo ... Collagen type XII, XIV fibrils [extracellular region] (Homo sapiens) * Collagen type XII fibril [extracellular region] (Homo ... Collagen type XII fibril [extracellular region] (Canis familiaris) Collagen type XII fibril [extracellular region] (Danio rerio ...
Niedbala W, Cai B, Wei X, Patakas A, Leung BP, McInnes IB et al. Interleukin-27 attenuates collagen-induced arthritis. Ann ... The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest 2008;118:1680-1690. * ... Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 2006;25:383-392. *CrossRef, ... Induction of type I diabetes by interferon-alpha in transgenic mice. Science 1993;260:1942-1946. *CrossRef, ...
... collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to ... Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of ... This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted ... collagen type XII alpha 1 chain. Enable Javascript to view the expand/collapse boxes.. Open All Close All ...
... that facilitate the interactions of adjacent collagen fibrils. Using immunohistochemistry and in situ hybridization, we ... Collagens XII and XIV are members of a subfamily of fibril-associated collagens with interrupted triple-helices (FACITs) ... Collagen / metabolism* * Collagen Type I / metabolism* * Collagen Type XII / metabolism* * Female * Fibril-Associated Collagens ... In contrast, collagen XII and XIV expression was low until 4 weeks after bleomycin treatment. Whereas collagen XII expression ...
Fibronectin type-IIIInterPro annotation. ,p>Information which has been generated by the UniProtKB automatic annotation system, ... Collagen alpha-1(XII) chainImported. ,p>Information which has been imported from another database using automatic procedures.,/ ... tr,E9PX70,E9PX70_MOUSE Collagen alpha-1(XII) chain OS=Mus musculus OX=10090 GN=Col12a1 PE=1 SV=1 ... IPR008160 Collagen. IPR013320 ConA-like_dom_sf. IPR003961 FN3_dom. IPR036116 FN3_sf. IPR013783 Ig-like_fold. IPR001791 Laminin_ ...
Fibronectin type-IIIInterPro annotation. Automatic assertion inferred from signature matchi ... Collagen alpha-1(XII) chainImported. ,p>Information which has been imported from another database using automatic procedures.,/ ... tr,A0A087X0A8,A0A087X0A8_HUMAN Collagen alpha-1(XII) chain OS=Homo sapiens OX=9606 GN=COL12A1 PE=1 SV=1 ... IPR008160 Collagen. IPR013320 ConA-like_dom_sf. IPR003961 FN3_dom. IPR036116 FN3_sf. IPR013783 Ig-like_fold. IPR001791 Laminin_ ...
... is an eagle-i resource of type Hybridoma cell line at eagle-i Network Shared Resource Repository. ... mouse anti-collagen type XII hybridoma (MT2). eagle-i ID. http://shared.eagle-i.net/i/00000140-d7a4-ab3e-fa61-b3d480000000 ... mouse anti-collagen type XII hybridoma (MT2) ... Inferred Types from the eagle-i Ontology (What is an ontology?) ...
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C- ... Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen".[citation needed] Collagen IV ... type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 ... Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase?". Alcoholism: ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions.. J. ... Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions.. J. ... Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins.. ... Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins.. ...
Molecular mechanisms for OI types I-IV are mutations in type 1 collagen genes COLA1 and COLA2. Types V-XII are rarer forms. ... Mutations in type II collagen cause a large number of disorders classified as spondyloepiphyseal dysplasia (ie, ... Infant with Beemer-type (left) and an infant with Majewski-type (right) short-rib syndrome (SRS). Note severe micrognathia/ ... Infant with Beemer-type (left) and an infant with Majewski-type (right) short-rib syndrome (SRS). Note severe micrognathia/ ...
Found to have type I, III, VI, and XII collagen. See also[edit]. *Connective tissue in skeletal muscle ... The overall comprehensive organization of the perimysium collagen network, as well as its continuity and disparateness, however ...
Urotensin Ⅱ promoted the expression of typecollagen in a time-and concentrationdependent manner.The level of typecollagen ... Objective To evaluate the effect of a vasoactive substance urotensin Ⅱ on the expression of typecollagen and migration of ... Effects of urotensin Ⅱ on the expression of typecollagen in human skin fibroblasts / 中华皮肤科杂志 ... Effects of urotensin Ⅱ on the expression of typecollagen in human skin fibroblasts ...
... and Collagen Type I Degradation Products With the Remodeling of the Left Ventricle in Patients With Acute Myocardial Infarction ... content of C-terminal telopeptide of collagen type I degradation products (ICTP) was measured by chemiluminescent immunoassay. ... In this work we revealed association of A allele of MMP20 rs2245803 with formation of dilative type of LV remodeling and ... Significant association was found between A allele of MMP 20 rs2245803 and dilation type of LV remodeling (odds ratio [OR] 2.82 ...
Objective To determine the serum levels of cross-linked telopoptide of typecollagen (ICTP),alkaline phosphatase (ALP) in ... Application of cross-linked telopeptide of typecollagen, alkaline phosphatase in bone tumor / 中国医师杂志 ... Application of cross-linked telopeptide of typecollagen, alkaline phosphatase in bone t ... Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Chinese Physician Year: 2013 Type: ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... Collagen, type I, alpha 1 (COL1A1) Collagen, type II, alpha 1 (COL2A1) Collagen, type III, alpha 1 (COL3A1) Collagen, type V, ... collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of VWA-containing proteins are ... "Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins". ...
Bone marrow stromal cells enhance prostate cancer cell invasion through type I collagen in an mmp-12 dependent manner. Int J ... 12.. Zeng XH, Ou ZL, Yu KD, Feng LY, Yin WJ, Li J, et al. Absence of multiple atypical chemokine binders (acbs) and the ... Matrix metalloproteinase-12 is associated with overall survival in chinese patients with gastric cancer. J Surg Oncol. 2013;107 ... Metalloelastase (mmp-12) expression by tumour cells in squamous cell carcinoma of the vulva correlates with invasiveness, while ...
Type XII collagen regulates osteoblast polarity and communication during bone formation.. Izu Y, Sun M, Zwolanek D, Veit G, ... Type XIV Collagen Regulates Fibrillogenesis: PREMATURE COLLAGEN FIBRIL GROWTH AND TISSUE DYSFUNCTION IN NULL MICE. ... Expression of type XXIII collagen mRNA and protein.. Koch M, Veit G, Stricker S, Bhatt P, Kutsch S, Zhou P, Reinders E, Hahn RA ... Collagen XII interacts with avian tenascin-X through its NC3 domain.. Veit G, Hansen U, Keene DR, Bruckner P, Chiquet-Ehrismann ...
The purified mass is dried to provide the desired Type I collagen product which may be ground into a powder or formed into a ... The enzyme-treated comminuted material which is rich in collagen is dispersed in an organic acid to cause the fibrillar mass to ... source such as poultry feet that incorporates a fibrillar mass of connective tissue as well as bony tissue to yield a collagen ... collagen matrix or sponge, depending on the end use therefor. ... A process for extracting type I collagen from an avian ...
Type 1 collagen, alpha 1 chain. Type 1 collagen is a fibril-forming collagen found in most connective tissues and is abundant ... Type I collagen production was high when cells were cultured on TCPS (Figure 2d). Unpredictably, the CICP release in 2D ... Type I collagen fibers are involved in aligning the mineral crystals, thus playing a pivotal role in mediating the apatite ... The synthesis of type I collagen was assessed by measuring its metabolic product released in the culture supernatant. Levels of ...
... and type XII collagen; and quantitative real-time polymerase chain reaction to analyze the expression patterns of the following ... Type in Product Names, Product Numbers, or CAS Numbers to see suggestions. ... and Col XII. Although there was no significant increase in tissue-forming ability among DPSCs after predifferentiation, ... genes: RUNX2, OC, DMP1, DSPP, POSTN, CP23, and Col XII. In DPSC transplants, the amount of new tissues was similar in all ...
Expression of type XII collagen by wound epithelial, mesenchymal, and ependymal cells during blastema. formation in ... identifies the urodele alpha 1 chain of type XII collagen, a developmentally regulated extracellular matrix. protein in ...
Collagen type XI alpha 1 chain. COL12A1. Collagen type XII alpha 1 chain ... slow type MYBPC1, troponin T1, slow skeletal type TNNT1, tropomodulin 4 TMOD4, leiomodin 3 LMOD3 and myosin light chain 10 ... Induction of alveolar type-II cell-differentiation in fetal tracheal epithelium by grafted distal lung mesenchyme. Dev Biol. ... The lung contains about 40 cell types and myofibroblasts represent 10% of mature lung cells. As the normal rate of regeneration ...
col12a1: collagen, type XII, alpha 1. 0.9. 0.3. 2.0. 2.0. EEMP1: EGF-containing fibulin-like extracellular matrix protein 1. 49 ... Collagen catabolism. 2.1. 0.4. None. None. mmp13: matrix metalloproteinase 13. 1. 1.1. 1.1. 3.2. 2.8. TIMP3: tissue inhibitor ... col6a3: procollagen, type VI, alpha 3. 86. 2.4. 0.8. None. None. ... VCIP: VEGF and type I collagen inducible protein. 42. Cell ...
The collagenous component is mainly type I collagen; however, other collagen types, such as II-VI, XI, XII, and XIV, are also ... Other types of collagen in the PDL are types III, V, VI, and XII (11, 12). It was previously shown that the 3D collagenous ... Verification of the collagen type was done by immunostaining of collagen type I and imaging by SHG with two photon emission; ... The major collagenous constituent is type I, and it is the only collagen that is embedded in both the tooth and the bone. ...
... collagen type XII α 1 chain. ... Cancer type. Target gene. (Refs.). Mitra et al, 2012. miR-155. ... MicroRNAs (miRNAs/miRs) are an abundant type of endogenous small RNA molecule that downregulate target gene expression (24). A ... Using the peptidase inhibitor, PT-100 (talabostat) was revealed to reduce the tumor growth rate in numerous types of tumor ... BIBF1120 has been applied clinically for the treatment of several types of tumor (102). Taken together, these findings suggest ...
  • Collagen alpha-1(XII) chain is a protein that in humans is encoded by the COL12A1 gene. (wikipedia.org)
  • This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. (wikipedia.org)
  • Collagen types XII and XIV belong to a subgroup of non-fibrillar-collagens termed (fibril-associated collagens with interrupted triple-helices) (FACIT) and may be involved in basement membrane regulation providing specific molecular bridges between fibrils and other matrix components. (springer.com)
  • Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. (wikipedia.org)
  • Type XII and XIV collagens associate with type I and type II fibrils. (reactome.org)
  • Collagens XII and XIV are members of a subfamily of fibril-associated collagens with interrupted triple-helices (FACITs) that facilitate the interactions of adjacent collagen fibrils. (nih.gov)
  • These data support the hypothesis that fibrosis is a multistep process that involves both collagen accumulation and changes in the molecules that modulate the biomechanical properties of fibrils. (nih.gov)
  • Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. (nih.gov)
  • Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. (news-medical.net)
  • Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen respectively. (news-medical.net)
  • Collagen consists of amino acids wound together to form triple- helices to form of elongated fibrils . (wikipedia.org)
  • The collagens constitute a large group of proteins in the extracellular matrix that can be divided into several distinct families. (springer.com)
  • Corneal wound healing is a complex process involving many cell types, signaling pathways, and proteins. (arvojournals.org)
  • Whereas collagen XII expression was greatest between 4 weeks and 8 weeks, expression of collagen XIV persisted from 4 to 12 weeks, which suggests that these two proteins may play distinct roles in the fibrotic process. (nih.gov)
  • The domain is named after the von Willebrand factor (VWF) type C repeat which is found in multidomain protein/multifunctional proteins involved in maintaining homeostasis. (wikipedia.org)
  • Each module has homologues in other extracellular mosaic proteins such as Von Willebrand factor, slit, thrombospondins, fibrillar collagens, IGF-binding proteins and mucins. (ebi.ac.uk)
  • Berg, R. A., Schwartz, M. L., and Crystal, R. G. (1980) Regulation of the production of secretory proteins: intracellular degradation of newly synthesized "defective" collagen. (springer.com)
  • Previously undetected bacterial homologues were identified for# plant pathogenesis-related proteins, Pad1, von Willebrand factor type A, src homology 3 and YWTD repeat-containing domains. (embl.de)
  • The functions of collagen XXIII are still unknown, although it is believed that they could be similar to other transmembrane proteins, such as collagen XIII . (wikidoc.org)
  • Apart from having the characteristic structure of transmembranous collagens, all three proteins present a high level of amino acid residue conservation in collagenous and non-collagenous domains. (wikidoc.org)
  • Also provided is an injectable composition comprising any type of collagen and passaged autologous fibroblasts substantially free of immunogenic proteins, e.g., culture medium serum-derived proteins, for correcting defects in skin, such as wrinkles or scars, and for augmenting tissue in the subject, particularly facial tissue. (google.es)
  • Collagens constitute nearly 30% of all proteins in our body. (pnas.org)
  • Up to 30 percent of all the protein in the human body is collagen, including up to 70 percent of the proteins in connective tissues. (purebulk.com)
  • Smooth muscle cells (SMCs), the major cellular constituents of the medial layer of an artery, are responsible for synthesis and deposition of connective tissue proteins (including types I and V collagen, elastin, and proteoglycans) during artery development. (ahajournals.org)
  • Cultured vascular SMCs from adult animals exhibit predominantly a synthetic phenotype, expressing genes encoding types I, III, and V/XI collagen at confluence or when deprived of serum growth factors, 8-10 whereas during exponential growth, only low levels of matrix proteins are produced. (ahajournals.org)
  • What is the structure of a typical collagen molecule? (brainscape.com)
  • According to Smart Skincare, even when this form of collagen enters the skin, the molecule fragments are too small to be able to integrate with the skin's own collagen. (truthinaging.com)
  • Dermatologists say that the collagen molecule is too large to be absorbed through the skin. (womenshealthmag.com)
  • The molecule of collagen XXIII can be found either in membrane-bond form or in shed form. (wikidoc.org)
  • Collagen XXIII molecule might be shed at Golgi apparatus or the cellular membrane . (wikidoc.org)
  • A common feature of transmembrane collagens is the presence of two forms of the molecule: a full-length membrane-bound form and an ectodomain shed form . (wikidoc.org)
  • These defects often cause problems in the biosynthesis of the collagen molecules, their assembly and posttranslational modification process that makes them their final end form of collagen. (news-medical.net)
  • Collagen I: This is the common form of collagen in the human body and it's the end product when tissue repair. (thebeautybrains.com)
  • Hydrolyzed collagen provides a bioavailable form of collagen that is readily processed by the body. (purebulk.com)
  • Collagen α-1 (XXIII) chain is a protein encoded by COL23A1 gene , which is located on chromosome 5q35 in humans, and on chromosome 11B1+2 in mice. (wikidoc.org)
  • In this gene transfer trial we plan to biopsy some skin tissue, grow the cells in a skin cell culture (sterile dishes with special fluid that allows cells to grow and multiply) and then infect the cells with a virus that we have genetically engineered to insert the correct type VII collagen gene. (clinicaltrials.gov)
  • The process of inserting the correct type VII collagen gene into cells is called 'gene transfer. (clinicaltrials.gov)
  • The virus is made so that it only delivers the type VII collagen gene and it should not spread to other parts of the body. (clinicaltrials.gov)
  • C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins [ PMID: 15476922 ]. (ebi.ac.uk)
  • This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. (genecards.org)
  • Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. (genecards.org)
  • COL4A5 (Collagen Type IV Alpha 5 Chain) is a Protein Coding gene. (genecards.org)
  • Furthermore, basic fibroblast growth factor (bFGF), a potent inducer of SMC proliferation, decreased α1(I) and α2(V) collagen gene expression at the transcriptional level in bovine SMCs. (ahajournals.org)
  • 12 The B- myb gene was isolated on the basis of its homology with c- myb in its DNA-binding region and encodes a 3.3- to 3.5-kb mRNA and ≈704-aa protein. (ahajournals.org)
  • 12,13,16-19 We demonstrated that B-Myb is a strong negative regulator of MBS-driven reporter activity and matrix gene promoters in cultured adult vascular SMCs. (ahajournals.org)
  • The collagen IV C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. (wikipedia.org)
  • Collagen is a mesh of fibers in the skin. (truthinaging.com)
  • reticulate (main component of reticular fibers ), commonly found alongside type I. (wikipedia.org)
  • [ 9 ] The collagen fibers in keloids are larger, thicker, and wavier and have a random orientation, whereas those in hypertrophic scars are oriented parallel to the epidermal surface. (medscape.com)
  • b) Collagen fibers lose their moist texture and become rigid. (nutritiongeeks.com)
  • When Super Collagen™ is taken internally, the body receives the raw materials it needs to supplement the collagen found in all of these areas and may act as a messenger to trigger the synthesis of new collagen fibers. (vitaminworld.com)
  • Tsutsumi Y, Tazawa K, Shibuya M. Type VI collagen immunoreactivity in skeinoid fibers in small intestinal stromal tumors. (southernbiotech.com)
  • What type of collagen is PureBulk's Hydrolyzed Chicken Collagen? (purebulk.com)
  • Please contact customer support to inquire about the types of collagen contained in our Hydrolyzed Chicken Collagen. (purebulk.com)
  • One day Dr. Moore read about some studies on chicken collagen which showed that a small amount taken orally could have a preventive effect on rheumatoid arthritis. (prohealth.com)
  • What Dr. Moore discovered was that, unlike grandma's chicken soup, if he cooked the chicken collagen, it became ineffective. (prohealth.com)
  • not processed by high heat or chemicals) chicken collagen using the chicken's sternum cartilage. (prohealth.com)
  • Objective To evaluate the effect of a vasoactive substance urotensin Ⅱ on the expression of type Ⅰ collagen and migration of human skin fibroblasts ,and to explore the underlying mechanisms of signal transduction . (bvsalud.org)
  • This is the collagen of granulation tissue, and is produced quickly by young fibroblasts before the tougher type I collagen is synthesized. (news-medical.net)
  • Bienkowski, R. S. (1984) Collagen degradation in human lung fibroblasts: extent of degradation, role of lysosomal proteases, and evaluation of an alternate hypothesis. (springer.com)
  • [ 11 ] Furthermore, fibroblasts isolated from keloids and hypertrophic scars have different mRNA transcription sequences -- keloids have an increased ratio of type I to type III collagen. (medscape.com)
  • Human fibroblasts were stained with Goat Anti-Type I Collagen-UNLB (SB Cat. (southernbiotech.com)
  • The purified mass is dried to provide the desired Type I collagen product which may be ground into a powder or formed into a collagen matrix or sponge, depending on the end use therefor. (google.co.uk)
  • 12. A process as set forth in claim 1, wherein the swollen powder is concentrated by precipitation which is effected by raising the pH. (google.co.uk)
  • Do Collagen Powder And Supplements Benefit Your Skin? (womenshealthmag.com)
  • Does Collagen Powder Do Anything For Your Skin? (womenshealthmag.com)
  • Collagen powder, supplements, and "shots" are popular products that promise to add more collagen to your skin, making it look younger and more supple. (womenshealthmag.com)
  • Well, according to every #influencer and wellness-obsessed celeb, that ingredient is collagen powder. (womenshealthmag.com)
  • One note: Collagen is not a complete protein (it's made up of only three amino acids, not nine, according to the Protein Data Bank ), so pure collagen powder doesn't have the same muscle-building, recovery-boosting abilities as your standard protein powder . (womenshealthmag.com)
  • Bluebonnet's Beautiful Ally™ Collagen Powder is specially formulated with collagen peptides types I + III, key structural components for lustrous hair, firm skin and durable nails. (vitacost.com)
  • It provides an overview of the approach used to treat such cases while emphasizing the feasibility of using 2 new products (in pediatric wound care): an antimicrobial skin and wound cleanser as well as type 1 hydrolyzed collagen powder. (o-wm.com)
  • Kolla2 is UnHydrolyzed Chicken Sternal Cartilage Collagen Type II powder or liquid concentrate. (nutritiongeeks.com)
  • Super Collagen™ is neutral in taste and is specifically formulated in an easy to take powder form. (vitaminworld.com)
  • content of C-terminal telopeptide of collagen type I degradation products (ICTP) was measured by chemiluminescent immunoassay. (cdc.gov)
  • The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance between synthesis and degradation. (springer.com)
  • Fitzgerald, J., Lamande, S. R., and Bateman, J. F. (1999) Proteasomal degradation of unassembled mutant type I collagen pro-alpha1(I) chains. (springer.com)
  • Journal Article] Orthodontic tensile strain induces angiogenesis via type iv collagen degradation by matrix metalloproteinase-12. (nii.ac.jp)
  • During the aging process, collagen levels deplete in the body, resulting in connective tissue degradation, which manifests as wrinkles, thinning cartilage, and brittle hair. (vitacost.com)
  • The intact trimeric noncollagenous 1 (NC1) domain of type X collagen, the marker we designated as CXM for Collagen X Marker, is a degradation by-product of endochondral ossification that is released into the circulation in proportion to overall growth plate activity. (sciencemag.org)
  • When I took a look, following a request from a reader, at Dermal FX and the Day and Night Cream ($149.95), which prominently features collagen and elastin the first thing that jumped to my mind was egg yolk. (truthinaging.com)
  • Unfortunately, it is right near the end of the ingredients list whereas collagen and elastin are the first two. (truthinaging.com)
  • As many metalloproteinases (MMPs), macrophage elastase (MMP-12) is able to degrade extracellular matrix components such as elastin and is involved in tissue remodeling processes. (scielo.br)
  • Depending on which amino acids are hooked together and how they form these sub structures you can generate 28 or 29 different types of collagen. (thebeautybrains.com)
  • Just in case this isn't confusing enough, in addition to the different TYPES of collagen, there are also different FORMS of each type of collagen. (thebeautybrains.com)
  • There are 12 different types of collagen throughout the body. (truthinaging.com)
  • Mutations to the genes coding for collagen IV lead to Alport syndrome . (wikipedia.org)
  • A family of growth regulators (originally called cef10, connective tissue growth factor, fisp-12, cyr61, or, alternatively, beta IG-M1 and beta IG-M2), all belong to immediate-early genes expressed after induction by growth factors or certain oncogenes. (ebi.ac.uk)
  • Comparing CAGE and microarray data sets, we furthermore identified a small number of genes that showed a receptor-dependent response in LECs, demonstrating that these receptors, despite activating very similar signaling pathways, fulfill overlapping but not identical functions within the same cell type (LECs). (nature.com)
  • Vuorio, E. and de Crombrugghe, B. (1990) The family of collagen genes. (springer.com)
  • The classical Sillence types of OI (types I-IV) with autosomal dominant inheritance comprise about 80-85% of cases and are caused by mutations in the genes that encode type I collagen, COL1A1 and COL1A2 . (nih.gov)
  • These types encompass the full spectrum of OI severity, from perinatal lethal type II to progressively deforming type III to mild and diagnostically delayed type I. The rare forms of OI (types V-XVIII) delineated in the last decade have (except for type V and some XV) autosomal recessive inheritance and are caused by mutations in genes whose protein products interact with collagen for post-translational modification or folding. (nih.gov)
  • Osteogenesis imperfecta (oi) is disorder of congenital bone fragility caused by mutations in the genes that codify for type i procollagen (ie, col1a1 and col1a2). (healthtap.com)
  • These form the most abundant collagens in vertebrates. (news-medical.net)
  • This is the most abundant collagen of the human body. (news-medical.net)
  • Type 1 and 2 are the most abundant in the skin. (truthinaging.com)
  • Collagen is the most abundant protein in the body, and the main building block for skin. (womenshealthmag.com)
  • Type I Collagen - The most abundant collagen in the body. (purebulk.com)
  • Kolla2 -ImmuCell is 100% pure chicken sternum cartilage collagen type II, the most abundant structural protein found in joints. (nutritiongeeks.com)
  • There are 29 genetically distinct collagens present in animal tissues. (news-medical.net)
  • Type I collagen is found throughout the body except in cartilaginous tissues. (news-medical.net)
  • Collagen / ˈ k ɒ l ə dʒ ɪ n / is the main structural protein in the extracellular space in the various connective tissues in animal bodies. (wikipedia.org)
  • Depending upon the degree of mineralization, collagen tissues may be either rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). (wikipedia.org)
  • Type XXIII collagen is expressed in both adult tissues and developing organs. (wikidoc.org)
  • Hydrolyzed collagen contains naturally-occurring glucosamine and hyaluronic acid , which support connective tissue repair and increase hydrating and volumizing effects - a result of the natural ability of connective tissues to hold water. (purebulk.com)
  • The associated variants, which have been identified to date, may contribute to the interindividual variation in the structure and, by implication, mechanical properties of the collagen fibril and surrounding matrix within musculoskeletal soft tissues, as well as their response to mechanical loading and other stimuli. (bmj.com)
  • Collagen is a protein (which means it's made of long strings of amino acids) and it's very rich in two amino acids in particular: proline and hydroxyproline. (thebeautybrains.com)
  • We describe Western immunoblotting of intact α1(I) collagen using antibodies directed to α1(I) collagen amino and carboxyl propeptides. (springer.com)
  • Furthermore, possible recognition sequences for furin (a major physiological protease ) cleavage sites have been found in both amino-terminal NC1 domain and carboxyl-terminal NC4 domain of each one of these collagens. (wikidoc.org)
  • Glycine, proline, alanine and hydroxyproline are some of the important amino acids provided by collagen I & III peptides and replenishing these amino acids helps to maintain collagen at healthy levels. (forresthealth.com)
  • Hydrolyzed collagen provides additional amounts of amino acids like glycine , lysine , and proline , which are specifically needed by the body to support connective tissue structure and maintain healthy cell function. (purebulk.com)
  • The amino acid content of hydrolyzed collagen is the same as collagen: 20 amino acids, including 8 out of 9 essential amino acids ( Wikipedia ) (lacking tryptophan ). (purebulk.com)
  • Many people have insufficient levels of the amino acids needed to make collagen due to poor food choices. (purebulk.com)
  • Collagen hydrolyzed provides additional amounts of the amino acids glycine and glutamine. (purebulk.com)
  • Taken as a food supplement, collagen hydrolyzed provides the proper ratios of amino acids needed for collagen production. (purebulk.com)
  • Parallels the amino acid structure of our own body s collagen type II. (nutritiongeeks.com)
  • The composition of Chicken Type II Collagen protein consists of eighteen amino acids. (nutritiongeeks.com)
  • The percentage and molecular weight of each amino acid is different than those found in Type I & III. (nutritiongeeks.com)
  • Super Collagen™ is enzymatically hydrolyzed, providing an amino acid ratio with a low molecular weight for maximum bioavailability and utilization by the body. (vitaminworld.com)
  • Other useful collagen boosters to keep an out for are aldenine , vitamin C and In addition to Matrixyl and Matrixyl 3000, other peptides are ChroLine and hexapeptide. (truthinaging.com)
  • Collagen "shots" (like juice shots, not injectables)-which generally contain collagen along with skin-boosting nutrients like vitamin C and copper peptides -promise to reduce the appearance of aging by improving skin tone and texture and firmness. (womenshealthmag.com)
  • Collagen I & III peptides are key to maintaining beautiful skin. (forresthealth.com)
  • Advanced Connective Tissue Formula specialized formulation includes highly-bioavailable, bovine-based Collagen Type 1 & 3 peptides, all natural hyaluronic acid extracted from rooster comb and vitamins. (forresthealth.com)
  • Collagen Type I & III is made up of protein peptides derived from pharmaceutical food grade bovine collagen. (forresthealth.com)
  • Collagen peptides help to replenish the nutrients lost over time, boosting collagen production while reducing its breakdown thereby enhancing the skin's hydration and natural elasticity while counteracting visible signs of aging. (vitacost.com)
  • Super Collagen™ is made up of the collagen peptides Type 1 & 3 which support collagen in skin, hair, nails, muscles, tendons, ligaments and bones. (vitaminworld.com)
  • van den Hooff had tentatively proposed that signal molecules emanating from the ECM, such as collagens and their peptides, could "contribute to at least one aspect of ultimate malignancy of neoplastic cells" [ 1 - 4 ]. (omicsonline.org)
  • Type XII collagen protein expression was evaluated by immunohistochemistry in human corneal scars and in a mouse model of corneal scarring at several time points (from day 7 to day 210) after full-thickness excision. (arvojournals.org)
  • Using immunohistochemistry and in situ hybridization, we analyzed the spatial and temporal expression pattern of collagens XII and XIV during bleomycin-induced pulmonary fibrosis. (nih.gov)
  • In the present study, we investigated MMP-12 expression level in 298 patients with cutaneous melanoma and 60 normal skin tissue specimens by immunohistochemistry assay. (springer.com)
  • There are at least twelve structural families of lectins, of which C-type (Ca+-dependent) lectins is one. (ebi.ac.uk)
  • Undernatured Type II Collagen is the principal structural protein in cartilage that is responsible for its tensile strength and toughness. (iherb.com)
  • Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. (abcam.com)
  • Collagen is a complex structural protein that maintains strength and flexibility throughout the body. (vitaminworld.com)
  • Prolyl 3-hydroxylation is a crucial posttranslational modification of collagens. (pnas.org)
  • Laboratory tested to naturally contain collagen type II protein, and hyaluronic acid, glucosamine, and chondroitin, Therefore, naturally provides all necessary components for maintaining health joints. (nutritiongeeks.com)
  • It contains 65-70% Collagen Type II and naturally contains 30-35% carbohydrates (chondroitin, glucosamine & hyaluronic acid), the major components of joint cartilage. (nutritiongeeks.com)
  • The mucopolysaccharides consists of Glucosamine, Chondroitin, and Hyaluronic Acid, the makeup of synovial fluid and sugar aminos required to make collagen type II cells. (nutritiongeeks.com)
  • A process for extracting type I collagen from an avian source such as poultry feet that incorporates a fibrillar mass of connective tissue as well as bony tissue to yield a collagen product having useful medical and biotechnology applications. (google.co.uk)
  • It makes sense that collagen has glue-like properties considering the role it plays in biology - it's a type of connective tissue that helps other structures "stick" together. (thebeautybrains.com)
  • Pathology of the collagen underpinning of the heart is understood within the category of connective tissue disease . (wikipedia.org)
  • Advanced Connective Tissue Formula may help epidermis cells turnover, improving the rate of water moving through the skin layer to support the water-binding function of the outermost part of the epidermis and stimulate collagen synthesis for healthy skin and connective tissue. (forresthealth.com)
  • Even if you want to believe in topical collagen, another problem is that the collagen molecules contained in most of these creams are much too large penetrate the surface of the skin. (truthinaging.com)
  • In these, the collagen molecules have been broken down into much smaller fragments, which are able to penetrate the skin's surface. (truthinaging.com)
  • What ratio of pro-collagen molecules are abnormal in type 2 osteogenesis imperfecta? (healthtap.com)
  • These results proved that MMP-12 expression was increased in cutaneous melanoma and associated with tumor progression. (springer.com)
  • Chemoresistance is defined as tumor resistance intrinsic or extrinsic to the chemotherapeutic treatment leading to recurrence of the disease or its progression to metastasis [ 12 ]. (hindawi.com)
  • Patients with stable or responding disease in either or both groups of treated lesions (halofuginone hydrobromide ointment or placebo ointment) may receive open-label treatment with topical halofuginone hydrobromide ointment to all 12 lesions for an additional 12 weeks as above in the absence of disease progression or unacceptable toxicity. (clinicaltrials.gov)
  • It has been shown that in prostate collagen XXIII expression is associated with tumor progression. (wikidoc.org)
  • Moreover, epigenetic silencing of P3H2 in breast cancers implies that the interaction between GPVI and non-3-hydroxylated type IV collagen might also play a role in the progression of malignant tumors and metastasis. (pnas.org)
  • Transforming growth factor β (TGFβ) is one of the crucial factors that alter the architecture of the tumor microenvironment to allow tumor progression ( 11, 12 ). (aacrjournals.org)
  • Both human and bovine collagen is widely used as dermal fillers for treatment of wrinkles and skin aging. (wikipedia.org)
  • Most medical collagen is derived from young beef cattle (bovine) from certified BSE -free animals. (wikipedia.org)
  • 12,15 Although B-Myb promotes G1/S phase transition in some cells, it does not induce proliferation of bovine SMCs and fails to cooperate with c-Myc to promote entry into S phase, unlike c-Myb and A-Myb. (ahajournals.org)
  • Other Ingredients: Super Collagen™ Type 1&3 derived from pharmaceutical food grade bovine collagen. (vitaminworld.com)
  • To investigate type XII collagen expression in corneal scars in vivo. (arvojournals.org)
  • Type XII collagen was overexpressed in human corneal scars in areas that were also positive for alpha-smooth muscle actin staining. (arvojournals.org)
  • In a mouse model of corneal wound injury we found that at 14 and 21 days postexcision, type XII collagen was largely concentrated in the subepithelial region of the cornea, especially in and near the wound bed. (arvojournals.org)
  • Corneal scars from a 7-month-old mouse revealed an overexpression of type XII collagen in the wound area similar to what we observed in human corneal scars. (arvojournals.org)
  • Type XII collagen is overexpressed in permanent human and mouse corneal scars and could represent a new target to treat corneal scarring. (arvojournals.org)
  • Directions: As a daily dietary supplement, dissolve one scoop of Super Collagen™ Dietary Supplement with one spoon of water or orange juice. (vitaminworld.com)
  • c) For each person ages 12-74 years, a Dietary Supplement form was self-administered and reviewed. (cdc.gov)
  • transmembrane collagen, interacts with integrin a1b1, fibronectin and components of basement membranes like nidogen and perlecan. (news-medical.net)
  • Expression of collagen I and III, fibronectin, versican, matrix metalloproteinase (MMP)-1, -2, -9 and -12 and tissue inhibitor of metalloproteinase-1 and -2 was quantified within the ASM in 22 FA and 10 control cases. (ersjournals.com)
  • Similarly, fibronectin, MMP-9 and MMP-12 were increased within the ASM in large airways of FA cases compared with controls. (ersjournals.com)
  • Therefore, in the present study, the expression of major lung ECM elements (collagens, elastic fibres, fibronectin and versican), members of the MMP family (MMP-1, -2, -9 and -12) and tissue inhibitors (TIMP-1 and -2) were determined within the ASM layer in the lung tissue of patients with asthma. (ersjournals.com)
  • However, according to Smart Skincare they still aren't able integrate with the skin's own collagen. (truthinaging.com)
  • Instead, look for products that boost your skin's collagen production, like retinol and vitamin C. (womenshealthmag.com)
  • Is there ANY way to boost your skin's collagen? (womenshealthmag.com)
  • According to 2013 research , compounds in gotu kola help increase collagen production and improve skin's tensile strength. (healthline.com)
  • C57Bl mice were treated with bleomycin (1 U, i.p., every other day for 8 days) or saline (control), and lung tissue samples were analyzed 2-12 weeks later. (nih.gov)
  • Serum Collagen IV concentrations correlate with hepatic tissue levels of collagen IV in subjects with alcoholic liver disease and hepatitis C and fall following successful therapy. (wikipedia.org)
  • Serum Markers for Hepatic Fibrosis in Alcoholic Liver Disease: Which is the Best Marker, Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase? (wikipedia.org)
  • The enzyme-treated comminuted material which is rich in collagen is dispersed in an organic acid to cause the fibrillar mass to undergo controlled swelling, after which the mass is separated from the bony tissue and purified to remove non-collangenous material. (google.co.uk)
  • In particular, 8-day predifferentiated PDLSC transplants formed tissue closer to the cementum/PDL complex in vivo as confirmed by the higher expression levels of POSTN, CP23, and Col XII. (sigmaaldrich.com)
  • For example Collagen XXII is present only at tissue junctions like those found in skeletal and heart muscle. (thebeautybrains.com)
  • Collagen III: Is found in fast growing tissue especially in early stages of wound repair. (thebeautybrains.com)
  • Collagen constitutes one to two percent of muscle tissue and accounts for 6% of the weight of strong, tendinous muscles. (wikipedia.org)
  • Bone is a dynamic tissue which undergoes continuous self-renewal, and bone homeostasis relies on functional equilibrium among three types of cells: osteoclasts essential for bone resorption, osteoblasts responsible for bone matrix formation, and osteocytes involved in the reception and transduction of mechanical stimuli and in the regulation of osteoclast/osteoblast differentiation and function [ 1 ]. (hindawi.com)
  • In addition, Type II is low in hydroxyproline and trace of hydroxylysine, the primary difference in comparison with Type I and III gearing type II to address cartilage tissue properties. (nutritiongeeks.com)
  • In addition, the effects of OF/LB and type V collagens on the phenotype of cultured breast cancer cells, as well as recent data on the active role played on neoplastic cells by collagen fragments originating from prominent tissue turn-over are summarized and discussed. (omicsonline.org)
  • The fraction of fibrous tissue was significantly lower in the ADTT group compared with the ABG group at both 6 and 12 months. (ovid.com)
  • The presence of cartilage chips in an osteochondral defect facilitated the formation of fibrocartilage as opposed to fibrous tissue at both 6 and 12 months posttreatment. (ovid.com)
  • In the infant DM, type IV collagen α1-α6 chains, perlecan, nidogen-1, nidogen-2, and netrin-4 were found on both faces, but they remained only on the endothelial face of the adult DM. (arvojournals.org)
  • Collagen chains undergo several posttranslational modifications that are indispensable for proper collagen function. (pnas.org)
  • There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network. (genecards.org)
  • Type III collagen is found in the walls of arteries and other hollow organs and usually occurs in the same fibril with type I collagen. (news-medical.net)
  • First, we're talking about collagen as an ingredient and not other agents that can boost collagen production. (thebeautybrains.com)
  • All in all, I believe it is better to look for active ingredients that may actually boost collagen production. (truthinaging.com)
  • These derivatives of vitamin A have been shown to increase collagen production in the skin," says Nazarian. (womenshealthmag.com)
  • Collagen XXIII is a type II transmembrane protein and the fourth in the subfamily of non-fibrillar transmembranous collagens. (wikidoc.org)
  • This kind of collagens have a single pass hydrophobic transmembrane domain. (wikidoc.org)
  • Collagens α1(XIII), α1(XXIII) and α1(XXV) display three collagenous domains (Col 1, Col 2, and Col 3) and four non-collagenous domains (NC1, which is also a transmembranous domain, NC2, NC3 and NC4). (wikidoc.org)
  • It has been reported that Col 1 domain of α1(XXIII) shows similarities with regions of both Col 1 and Col 2 domains of collagen types α1(XIII) and α1(XXV), whilst sequences of Col 2 and Col 3 domains of α1(XXIII) are related to the Col 3 domain of types α1(XIII)and α1(XXV). (wikidoc.org)
  • The activity of this protease is vital to explain the origin of the two forms that collagen types XIII, XXIII and XXV can adopt. (wikidoc.org)
  • Increased glomerular and mesangial deposition of collagen IV occurs in diabetic nephropathy and increased urinary levels are associated with the extent of renal injury. (wikipedia.org)
  • In addition to the above mentioned disorders, excessive deposition of collagen occurs in scleroderma. (news-medical.net)
  • Collagen occurs in many places throughout the body. (wikipedia.org)
  • Gradual calcium deposition within collagen occurs as a natural function of aging. (wikipedia.org)
  • The results are similar, but trophoblast outgrowth on collagen occurs radially at the surface while on Matrigel it occurs predominantly in a downward direction into the gel. (protocol-online.org)
  • Under control conditions of 20% oxygen and serum free medium, cell proliferation occurs during the first 24 h after which it ceases and further outgrowth on collagen, which continues for up to about 5 days, represents the reorganisation of an existing pool of cells from a thick column at the villous tip to a sheet only a few cells thick at the collagen gel surface. (protocol-online.org)
  • Cellular and humoral anti-collagen immune mechanisms appear to be involved in the pathogenesis of arthritis. (nih.gov)
  • Increased expression of human macrophage metalloelastase (mmp-12) is associated with the invasion of endometrial adenocarcinoma. (springer.com)
  • Alternative splice variants of the NC3 and NC1 domains of type XII collagen were investigated in the mouse wound-healing model using RT-PCR. (arvojournals.org)
  • The measurement of α1(I) collagen mRNA levels using real-time polymerase chain reaction is then outlined. (springer.com)
  • Aortic SMCs from adult transgenic animals displayed decreased α1(I) collagen mRNA levels. (ahajournals.org)
  • For example, in the developing intestine, collagen type-XII was present in the basement membrane zones of epithelia and endothelia. (springer.com)
  • However, collagen type-XIV was restricted to the mesothelial basement membrane zones. (springer.com)
  • The alpha-3 subunit (COL4A3) of collagen IV is thought to be the antigen implicated in Goodpasture syndrome , wherein the immune system attacks the basement membranes of the glomeruli and the alveoli upon the antigenic site on the alpha-3 subunit becomes unsequestered due to environmental exposures. (wikipedia.org)
  • The alpha 3 protein constituent of type-IV collagen is thought to be the antigen implicated in goodpasture's syndrome , wherein the immune system attacks the basement membranes of the glomeruli and the alveoli . (wikidoc.org)
  • Type IV collagen is a major and crucial component of basement membranes. (pnas.org)
  • We conclude that both collagens might well be able to serve different functions during human embryonic development although their structures are highly similar. (springer.com)
  • Thus, 3-hydroxylation of type IV collagen is indispensable for embryonic development in mice. (pnas.org)
  • The mechanism of the unexpectedly early lethality involves the interaction of non-3-hydroxylated embryonic type IV collagen with the maternal platelet-specific glycoprotein VI (GPVI). (pnas.org)
  • Skin, Laminins, Collagens, and Extra Cellular Matrix, with particular interest in skin wound repair and countermeasures to sulfur mustard damage. (rutgers.edu)
  • Liver fibrosis and cirrhosis are associated with the deposition of collagen IV in the liver. (wikipedia.org)
  • Fibroblast activation protein α (FAPα) is a cytomembrane protein that is selectively expressed by activated CAFs in various types of human epithelial cancer ( 13 ). (spandidos-publications.com)
  • However, epithelial cells could be one of the main targets of rhMMP-12 in our model. (scielo.br)
  • As a first step toward the elucidation of their possible cell biological functions, we compared the distribution of the two collagens during human organogenesis at the light microscopical level. (springer.com)
  • The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform infrared spectroscopy. (wikipedia.org)
  • However, the clinical significance of matrix metalloproteinasis (MMP)-12 in human cutaneous melanoma has not been addressed yet. (springer.com)
  • Collagen in topical cosmetics (as opposed to collagen injections) only treats the surface layer of the skin, and even if it is identical to human protein, it won't supplement collagen deficiencies. (truthinaging.com)
  • They concluded that at the nucleotide level, human and rat collagen XXIII alpha 1 show 76% identity. (wikidoc.org)
  • However, as very few data regarding the direct involvement of MMP-12 in inflammatory process in the airways were available, we have instilled a recombinant form of human MMP-12 (rhMMP-12) in mouse airways. (scielo.br)
  • Purified Human Type I Collagen (SB Cat. (southernbiotech.com)
  • Rasmussen LM, Hansen PR, Ledet T. Homocysteine and the production of collagens, proliferation and apoptosis in human arterial smooth muscle cells. (southernbiotech.com)
  • Collagen type VI expression during cardiac development and in human fetuses with trisomy 21. (southernbiotech.com)
  • Collagen is one of the many types of protein found in skin, bone, joints, muscles and internal organs. (purebulk.com)
  • Derived from chicken sternum cartilage, UC-II is a patented form of Undernatured (native) Type II Collagen that works with the immune system to support healthy joints. (iherb.com)
  • a) As we age, the body s ability to make collagen protein slows down so there is insufficient new collagen to make skin, joints and other parts of the body. (nutritiongeeks.com)
  • Rated 5 out of 5 by Toni from Excellent Product Collagen has improved the overall feel of my joints and my hair is fuller stronger and shiny. (vitaminworld.com)
  • however, other collagen types, such as II-VI, XI, XII, and XIV, are also found in ligaments and at their bony interfaces ( 1 ⇓ ⇓ ⇓ - 5 ). (pnas.org)
  • therefore, in areas of ligaments that are working under compression loads as well as in pathological conditions, a mixture of type II collagen and GAGs which absorb compressive loads efficiently, are found ( 6 ). (pnas.org)
  • Collagen is made by specialized cells in the skin, ligaments, bones and cartilage. (purebulk.com)
  • The primary protein in cartilage, Type II Collagen (CII) is crucial to joint health and function. (brightsurf.com)