Collagen Type XII: A fibril-associated collagen found in many tissues bearing high tensile stress, such as TENDONS and LIGAMENTS. It is comprised of a trimer of three identical alpha1(XII) chains.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Factor XII: Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Toll-Like Receptors: A family of pattern recognition receptors characterized by an extracellular leucine-rich domain and a cytoplasmic domain that share homology with the INTERLEUKIN 1 RECEPTOR and the DROSOPHILA toll protein. Following pathogen recognition, toll-like receptors recruit and activate a variety of SIGNAL TRANSDUCING ADAPTOR PROTEINS.Dendritic Cells: Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).Interferon Type I: Interferon secreted by leukocytes, fibroblasts, or lymphoblasts in response to viruses or interferon inducers other than mitogens, antigens, or allo-antigens. They include alpha- and beta-interferons (INTERFERON-ALPHA and INTERFERON-BETA).Toll-Like Receptor 4: A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA.Toll-Like Receptor 1: A pattern recognition receptor that forms heterodimers with TOLL-LIKE RECEPTOR 2.Toll-Like Receptor 2: A pattern recognition receptor that forms heterodimers with other TOLL-LIKE RECEPTORS. It interacts with multiple ligands including PEPTIDOGLYCAN, bacterial LIPOPROTEINS, lipoarabinomannan, and a variety of PORINS.Interferons: Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions.Anti-Glomerular Basement Membrane Disease: An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Basement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Collagen Type IV: A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.Hearing Loss, Sensorineural: Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM.Hemoptysis: Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Peptide Termination Factors: Proteins that are involved in the peptide chain termination reaction (PEPTIDE CHAIN TERMINATION, TRANSLATIONAL) on RIBOSOMES. They include codon-specific class-I release factors, which recognize stop signals (TERMINATOR CODON) in the MESSENGER RNA; and codon-nonspecific class-II release factors.Muridae: A family of the order Rodentia containing 250 genera including the two genera Mus (MICE) and Rattus (RATS), from which the laboratory inbred strains are developed. The fifteen subfamilies are SIGMODONTINAE (New World mice and rats), CRICETINAE, Spalacinae, Myospalacinae, Lophiomyinae, ARVICOLINAE, Platacanthomyinae, Nesomyinae, Otomyinae, Rhizomyinae, GERBILLINAE, Dendromurinae, Cricetomyinae, MURINAE (Old World mice and rats), and Hydromyinae.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.von Willebrand Factor: A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.Fatigue: The state of weariness following a period of exertion, mental or physical, characterized by a decreased capacity for work and reduced efficiency to respond to stimuli.von Willebrand Diseases: Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Ristocetin: An antibiotic mixture of two components, A and B, obtained from Nocardia lurida (or the same substance produced by any other means). It is no longer used clinically because of its toxicity. It causes platelet agglutination and blood coagulation and is used to assay those functions in vitro.Factor VIII: Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.Platelet Glycoprotein GPIb-IX Complex: Platelet membrane glycoprotein complex essential for normal platelet adhesion and clot formation at sites of vascular injury. It is composed of three polypeptides, GPIb alpha, GPIb beta, and GPIX. Glycoprotein Ib functions as a receptor for von Willebrand factor and for thrombin. Congenital deficiency of the GPIb-IX complex results in Bernard-Soulier syndrome. The platelet glycoprotein GPV associates with GPIb-IX and is also absent in Bernard-Soulier syndrome.Bone Diseases, DevelopmentalDwarfism: A genetic or pathological condition that is characterized by short stature and undersize. Abnormal skeletal growth usually results in an adult who is significantly below the average height.Osteochondrodysplasias: Abnormal development of cartilage and bone.Musculoskeletal Abnormalities: Congenital structural abnormalities and deformities of the musculoskeletal system.Achondroplasia: An autosomal dominant disorder that is the most frequent form of short-limb dwarfism. Affected individuals exhibit short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and mid-face hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, GENU VARUM, and trident hand. (Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim, MIM#100800, April 20, 2001)Thanatophoric Dysplasia: A severe form of neonatal dwarfism with very short limbs. All cases have died at birth or later in the neonatal period.Growth Disorders: Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Serial Publications: Publications in any medium issued in successive parts bearing numerical or chronological designations and intended to be continued indefinitely. (ALA Glossary of Library and Information Science, 1983, p203)Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Poultry: Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Foot: The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.Cell Hypoxia: A condition of decreased oxygen content at the cellular level.eIF-2 Kinase: A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.Adaptation, Physiological: The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.Anoxia: Relatively complete absence of oxygen in one or more tissues.Cell Fractionation: Techniques to partition various components of the cell into SUBCELLULAR FRACTIONS.Activating Transcription Factor 4: An activating transcription factor that regulates the expression of a variety of GENES involved in amino acid metabolism and transport. It also interacts with HTLV-I transactivator protein.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Tensile stress-dependent collagen XII and fibronectin production by fibroblasts requires separate pathways. (1/14)

The intracellular mechanisms controlling mechano-dependent production of the two extracellular matrix proteins collagen XII and fibronectin were analyzed. Fibroblasts were cultured on either tensed (attached) or released (floating) collagen type-I gels, respectively. Collagen XII and fibronectin production was three- to fivefold higher under tensed than under released conditions. The general inhibitor of tyrosine phosphorylation, genistein (50 microM), and the MAP kinase inhibitor PD98059 (20 microM) selectively reduced collagen XII accumulation by tensed cultures. Addition of PD98059, but not genistein, downregulated tensile stress-induced tyrosine phosphorylation levels of ERK1/2 and focal adhesion kinase. Staurosporine as well as pretreatment with phorbol ester, which constitute means to downregulate classical and novel PKC activity, specifically blocked collagen XII but not fibronectin accumulation in tensed fibroblasts. ERK1/2 phosphorylation levels were not affected by staurosporine treatment. Chronic exposure to the protein kinase C inhibitors bisindolylmaleimide and calphostin C blocked increased production of both fibronectin and collagen XII from cells under tension. The data manifest that the mechano-dependent production of collagen XII and fibronectin requires separate pathways. The FAK-ERK1/2 pathway, a genistein-sensitive tyrosine kinase, and a distinct classical/novel PKC appear selectively required for increased production of collagen XII in cells under tensile stress, whereas fibronectin induction is regulated by a different PKC-dependent pathway.  (+info)

Differential expression of type XII collagen in developing chicken metatarsal tendons. (2/14)

Type XII collagen is a fibril-associated collagen with multiple functional domains. The purpose of this work was to determine its role in regulating tendon matrix assembly. The temporal and spatial expression patterns of both collagen and mRNA were analysed in developing chicken metatarsal tendons using immunofluorescence microscopy, in situ hybridization and real-time quantitative PCR. Temporally, type XII collagen was present during all stages of development (day 14-hatch). However, spatially, type XII collagen expression shifted from the entire tendon at day 14, when the tendon is immature and fascicles are not well developed, to the interfacial matrix (endotendinium) associated with developing fascicles. This shift was obvious beginning at day 17, becoming prominent at day 19. Associated with this shift was a gradual decrease in type XII collagen reactivity in the tendon proper (non-sheath). By hatching, the reactivity was sequestered almost exclusively to the sheaths with some reactivity remaining at the fibroblast-matrix interface within the fascicle. In situ hybridization indicated that fibroblasts in the tendon expressed type XII collagen mRNA homogeneously at day 14. However, by hatching, when the tendon matures, type XII collagen is restricted primarily to the sheath cells. Quantitative PCR analyses, of NC3 splice variants, demonstrated highest expression levels for the short splice variant mRNA at days 14-17, followed by a significant decrease at day 19 with levels remaining constant to adult. Long variant mRNA expression was highest at day 14 then decreased and was constant from day 17 to adult. These changing patterns may be related to the spatial shift in type XII collagen expression to the sheaths. Differential temporal and spatial expression patterns indicate that type XII collagen functions to integrate the developing tendon matrices and fascicles into a functional unit.  (+info)

Expression of FACIT collagens XII and XIV during bleomycin-induced pulmonary fibrosis in mice. (3/14)

Collagens XII and XIV are members of a subfamily of fibril-associated collagens with interrupted triple-helices (FACITs) that facilitate the interactions of adjacent collagen fibrils. Using immunohistochemistry and in situ hybridization, we analyzed the spatial and temporal expression pattern of collagens XII and XIV during bleomycin-induced pulmonary fibrosis. C57Bl mice were treated with bleomycin (1 U, i.p., every other day for 8 days) or saline (control), and lung tissue samples were analyzed 2-12 weeks later. Collagen I protein expression was increased in the lung 2 weeks post bleomycin treatment and persisted for at least 12 weeks. In contrast, collagen XII and XIV expression was low until 4 weeks after bleomycin treatment. Whereas collagen XII expression was greatest between 4 weeks and 8 weeks, expression of collagen XIV persisted from 4 to 12 weeks, which suggests that these two proteins may play distinct roles in the fibrotic process. The mRNA for lysyl oxidase (LOX), an enzyme for cross-linking of collagens, had a delayed increase in the lung after bleomycin administration. It reached a maximum after 8 weeks, and persisted throughout the 12 weeks of the study. These data support the hypothesis that fibrosis is a multistep process that involves both collagen accumulation and changes in the molecules that modulate the biomechanical properties of fibrils.  (+info)

Collagen XII interacts with avian tenascin-X through its NC3 domain. (4/14)

Large oligomeric proteins often contain several binding sites for different molecules and can therefore induce formation of larger protein complexes. Collagen XII, a multidomain protein with a small collagenous region, interacts with fibrillar collagens through its C-terminal region. However, no interactions to other extracellular proteins have been identified involving the non-collagenous N-terminal NC3 domain. To further elucidate the components of protein complexes present close to collagen fibrils, different extracellular matrix proteins were tested for interaction in a solid phase assay. Binding to the NC3 domain of collagen XII was found for the avian homologue of tenascin-X that in humans is linked to Ehlers-Danlos disease. The binding was further characterized by surface plasmon resonance spectroscopy and supported by immunohistochemical co-localization in chick and mouse tissue. On the ultrastructural level, detection of collagen XII and tenascin-X by immunogold labeling confirmed this finding.  (+info)

Extracellular matrix gene alternative splicing by trabecular meshwork cells in response to mechanical stretching. (5/14)

PURPOSE: Elevated intraocular pressure (IOP), sensed as mechanical stretching by trabecular meshwork (TM) cells, triggers extracellular matrix (ECM) remodeling. In addition to changes in gene expression, alternative mRNA splicing may alter ECM protein isoforms. Changes in mRNA expression and alternative splicing of four ECM molecules in response to mechanical stretching of TM cells were investigated. METHODS: Porcine TM cells were mechanically stretched for 12, 24, or 48 hours. RNA was isolated, and RT-PCR was performed with primers that flanked alternatively spliced domains. PCR products were identified by DNA sequencing. Quantitative RT-PCR (qRT-PCR) was performed with primers positioned within nonspliced and spliced regions of the genes. RESULTS: Total levels of tenascin C, collagen type XII, and CD44 mRNA were increased, whereas versican mRNA levels were decreased in response to the mechanical stretch. In addition, each of these genes expressed alternate mRNA isoforms. Transcripts containing the fibronectin type III domain D of tenascin C, the long NC3 isoform of collagen type XII, the V1 isoform of versican, and exons v7 and v8 of CD44 all increased in response to mechanical stretching. A novel isoform of collagen type XII was observed that resulted in deletion of two exons, a frameshift, and a premature stop codon. This isoform was expressed only by stretched TM cells. CONCLUSIONS: These alternative splicing events led to the modulation of potential GAG attachment sites and other ECM-binding motifs. These changes should affect TM cell-ECM and/or protein-protein interactions during the ECM remodeling that occurs coincident with homeostatic restoration of IOP to normal.  (+info)

Mechanical strain increases expression of type XII collagen in murine osteoblastic MC3T3-E1 cells. (6/14)

In adult mouse, the mRNA corresponding to the alpha1 chain of type XII collagen (alpha 1(XII)) is predominantly detected in the bone. Additionally, murine osteoblastic cells, MC3T3-E1, increased the mRNA level of alpha 1(XII) response to the mechanical strain in the stretch culture system. Cyclic stretch stress resulted in a threefold increase in mRNA level of alpha 1(XII) as compared to the control experiment in MC3T3-E1. Transient transfection assays employing a reporter construct, together with site-directed mutagenesis studies, suggested that the AP-1 binding site in the first exon of mouse alpha 1(XII) gene is important for stretch stress-mediated upregulation of alpha 1(XII) expression. Electrophoretic mobility shift assay and associated antibody supershift experiments showed that stretch stress promotes the binding of c-Jun and JunD. Further chromatin immunoprecipitation experiments confirmed the participation of these transcription factors in the region. Also, the exogenous induction of the dominant negative form of c-Jun canceled the effect of stretch stress on the stimulation of the alpha 1(XII) gene. Here, we reported a potential responsive element to the stretch stress in mouse alpha 1(XII) gene. These data will provide new information on the mechanical strain-mediated transcriptional control of alpha 1(XII)-mediated fibrillogenesis in the bone.  (+info)

Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation. (7/14)

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Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma. (8/14)

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Results 77 SLE and 100 controls, all female. SLE vs control group: Mean of age ys: 34 (19-49)vs 38 (19-60). Prevalence of depression: 52% (44/77) vs 29% (29/100) (p,0.05). Prevalence of fatigue (FACIT,40): 42% (33/77) and 36% (36/100) (p,0.05). Mean disease duration (months) 48 (24-114). Socio-demographic characteristics, SLICC/SLEDAI, clinical and serological manifestations were not correlated with major depression p,0.05. FACIT: Median value: 31 (range 22-40) SLE group. FACIT,22 total SLE: 12/77 (15%) and FACIT,40: 33/77 (42%). Cut points FACIT SLE vs controls: ,22: 15% (12/77) vs 1% (1/100) (p,0.05), 30% sensitivity/100% specificity, 100% PPV and 57% NPV. AUC FACIT ,22: 0.65 (0.65-0.77). FACIT,40 in SLE vs controls: 42% (33/77) vs 26% (26/100) (p,0.05), 69% sensitivity and 84% specificity, 82% PPV and 70% NPV. AUC FACIT,40: 0.75 (0.64-0.87). ...
texdoc xii work (show the pdf) No, because there is no xii*pdf in TL or CTAN. if not Id leave things as they are. Ack. I wondered about adding the new one into the existing xii package Ack. Thanks, Karl ...
Sola dosis facit venenum-thats the Latin phrase (no pun intended) representing the basic principle of toxicology. It means that a substance will produce a harmful effect on a biological system only if it accumulates above a certain concentration within the biological system. From the turf pathology perspective, the appropriate interpretation is that in order to […]. ...
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Show moreCollagen XIV is a fibril-associated collagen with an interrupted triple helix (FACIT). Previous studies have shown that this collagen type regulates early stages of fibrillogenesis in connective tissues of high mechanical demand. Mice null for Collagen XIV are viable, however formation of the interstitial collagen network is defective in tendons and skin leading to reduced biomechanical function. The assembly of a tightly regulated collagen network is also required in the heart, not only for structural support but also for controlling cellular processes. Collagen XIV is highly expressed in the embryonic heart, notably within the cardiac interstitium of the developing myocardium, however its role has not been elucidated. To test this, we examined cardiac phenotypes in embryonic and adult mice devoid of Collagen XIV. From as early as E11.5, Col14a1(-/-) mice exhibit significant perturbations in mRNA levels of many other collagen types and remodeling enzymes (MMPs, TIMPs) within the ...
This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Although the function of this collagen is not known, other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. The transcript produced from this gene has an unusually large 3 UTR which has not been completely sequenced. [provided by RefSeq, Jul 2008 ...
Collagen, type XV, alpha 1, also known as COL15A1, is a human gene.[1] This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Type XV collagen has a wide tissue distribution but the strongest expression is localized to basement membrane zones so it may function to adhere basement membranes to underlying connective tissue stroma. Mouse studies have shown that collagen XV deficiency is associated with muscle and microvessel deterioration.[1] ...
On Wed, 20 Dec 2017, Peter Wilson wrote: , \usr\local\texlive\2017\texmf-dist\doc\plain. I feel that the TDS should be , organized in this case so that pdftex xii will produce xii.pdf (and , similarly for xii-lat or other (La)TeX files of the same nature). Not very good idea. It would add sooooo many files to the search space, with a high probability of file name clashes etc. No, doc files will not be automatically searched by kpathsea. They (the doc files) *are* different beasts and not supposed to be input files *unless* you want to typeset the documentation. Norbert -- PREINING Norbert http://www.preining.info Accelia Inc. + JAIST + TeX Live + Debian Developer GPG: 0x860CDC13 fp: F7D8 A928 26E3 16A1 9FA0 ACF0 6CAC A448 860C DC13 ...
SOAL REMEDIAL BIOLOGI KLS XII IPA 4-6 TUGAS REMEDIAL XII IPA Kerjakan soal - soal di bawah ini sesuai dg ketentuan ! A.Soal PG da ...
VÕISTLUS: võistlus seisneb orienteerumispäevakutel osalemises. Iga liikme osaluskord suvalisel orienteerumispäevakul toob tema organisatsioonile ühe arvestuspunkti. Ühel päevakul saab üks võistleja teenida vaid ühe arvestuspunkti. Võistlus toimub organisatsioonide vahel. Suve jooksul enim arvestuspunkte kogunud organisatsioon on karikasarja võitja. Osaleja võib päevakul osaleda temale sobivas võistlusklassis, kaasa arvatud vabaklass. Arvesse lähevad 05.04.2009 kuni 10.09.2009 toimuvad päevakud ja boonusena 5.-6. juunil 2009 toimuva Kalevi Suvejooksu mõlemad päevad ning 2010 septembris toimuva XII Vironia O-päeva tulemused. Arvestusse ei lähe teised eelregistreerimisega võistlused. Eestis toimuvad päevakud on toodud EOL-i kodulehel: http://www.orienteerumine.ee/paevak/index.php ...
... , Authors: Salvatore Romeo, Pancras CW Hogendoorn. Published in: Atlas Genet Cytogenet Oncol Haematol.
Toronto, Ontario - June 7, 2012. The Ontario Institute for Cancer Research (OICR) today announced $1.5 million in funding over three years for the development of a new drug by Toronto-based Fluorinov Pharma, Inc. The drug, called FV-162, is a highly potent, orally-delivered small molecule proteasome inhibitor with significant advantages over drugs currently used to treat multiple myeloma and some forms of Non-Hodgkins lymphoma.. "Our investment in Fluorinov Pharma Inc. will move FV-162 towards the market by helping it to meet the preclinical requirements of Health Canada and the FDA," said Mr. Frank Stonebanks, Vice-President, Commercialization and Chief Commercial Officer of OICR. "This novel drug is very promising and could improve the quality of life and outcomes of patients with certain blood cancers.". An important target for therapies treating blood cancers such as multiple myeloma is the proteasome, a part of the cell that recycles old proteins. While effective, the current proteasome ...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Nam liber tempor cum soluta nobis eleifend option congue nihil imperdiet doming id quod mazim placerat facer possim assum. Typi non habent claritatem insitam; est usus legentis in iis qui facit eorum claritatem. Investigationes demonstraverunt lectores legere me lius quod ii legunt saepius.. ...
Trappist Westvleteren 12 (XII) is a Quadrupel (Quad) style beer brewed by Brouwerij Westvleteren (Sint-Sixtusabdij van Westvleteren) in Westvleteren, Belgium. 4.6 average with 6429 ratings, reviews and opinions.
Trappist Westvleteren 12 (XII) is a Quadrupel (Quad) style beer brewed by Brouwerij Westvleteren (Sint-Sixtusabdij van Westvleteren) in Westvleteren, Belgium. 4.6 average with 6429 ratings, reviews and opinions.
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Logical Images, Inc. d/b/a VisualDx (hereinafter "VisualDx", "we", "us", or "our") has created this Acceptable Use Policy, Medical Disclaimer, & Copyright Notice (this "Notice") to inform you (hereinafter "you", "your", or "yourself") as a purchaser of a license for and/or user of the software hosted by VisualDx known as VisualDx (the "Software") of certain important terms and conditions set forth in the VisualDx End User License Agreement that governs your license for and/or use of the Software (the "EULA"). This Notice is subject to all of the terms and conditions set forth in the EULA and does not replace or limit it in anyway. You should read the EULA in detail prior to purchasing a license for or using the Software to make sure you understand and agree to its terms and conditions. Nothing in this Notice will (a) expand your rights or VisualDx′s obligations under the EULA or (b) modify or otherwise affect any terms and conditions of the EULA or the rights of the parties under the EULA. In ...
1019 views. Kalimantan Barat - KUBU RAYA. Kepala Penerangan Komando Daerah Militer (Kapendam) XII/Tanjungpura Kolonel Infanteri Tri Rana Subekti, S.Sos, memberikan keterangan kepada awak media, bahwa sejumlah Prajurit Kodam XII/Tpr yang tergabung Pasukan Perdamaian PBB, telah kembali ke Kodam XII/Tpr, Jum`at (30/12/2016).. Kapendam XII/Tpr Kolonel Inf Tri Rana Subekti mengatakan, prajurit Kodam XII/Tpr sebanyak 18 Prajurit termasuk satu Kowad yang tergabung dalam misi Perdamaian PBB sebagai Satgas TNI Konga Unifil Lebanon, bertugas selama satu tahun telah kembali ke tanah air dengan selamat.. Perlu kita ketahui bersama, sesuai UU RI No. 34 Tahun 2004 tentang TNI disebutkan, bahwa tugas pokok TNI tersebut dilakukan dengan Operasi Militer untuk Perang (OMP) dan Operasi Militer Selain Perang (OMSP). Sedangkan OMSP sendiri salah satunya adalah melaksanakan tugas perdamaian dunia sesuai dengan kebijakan politik luar negeri, terang Kapendam XII/Tpr.. Sementara Prajurit Kodam XII/Tpr yang tergabung ...
IF we examine the bright bow of Iris painted on the heavens by the sunbeams that break through the parting storm-clouds, no matter how closely we may scan it, we shall not be able to determine where the colors begin or end. As in this arch the blue gradually passes over into a green, and the green in turn changes insensibly into a yellow, even thus we find, in the countless forms in which Nature delights, the most delicate gradations, the most gradual transitions. Natura non facit saltus: this saying of Linnés is realized everywhere in the ever-changeful realm of life.. How difficult a matter it is to decide whether the lung-fish of Brazil and Senegambia belong to the amphibia or to the fishes, which in other instances are known to always breathe by their gills! In the rainless season of the year the swamps, the homes of these animals, dry out; they then coat themselves with a crust of earth, and are dependent on their lungs for every breath they draw. During the rest of the year they can use ...
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No-ti-ce is gi-ven in terms of Re-gu-la-ti-ons pu-blis-hed in Go-vern-ment No-ti-ce No R.324, 325, 326, and 327, ac-cor-ding to C-hap-ter 5 of the Na-ti-o-nal En-vi-ron-men-tal Ma-na-ge-ment Act (Act 107 of 1998) of the ap-pli-ca-ti-on for an EIA Ba-sic As-ses-sment Aut-ho-ri-sa-ti-on, which will be sub-mit-ted to Eastern Ca-pe Pro-vin-ces De-part-ment of E-co-no-mic De-ve-lop-ment, En-vi-ron-men-tal Af-fairs & Tou-rism for the pur-po-se of:. • Pro-po-sed chan-ge of lan-du-se to In-s-ti-tu-ti-o-nal I and II for hos-pi-tal, Re-si-den-ti-al II and IV, Con-sent for Re-ti-re-ment Pur-po-ses, and as-so-ci-a-ted In-fra-struc-tu-re:. GN 327 Lis-ting 1, Acti-vi-ty 12 The de-ve-lop-ment of (vi) bulk storm-wa-ter out-let struc-tu-res ex-cee-ding 100 sqm in si-ze, (x) buil-dings ex-cee-ding 100 sqm in si-ze, and (xii) in-fra-struc-tu-re or struc-tu-res with a phy-si-cal foot-print of 100 sqm or mo-re (c) within 32m from a wa-ter-cour-se.. GN 327 Lis-ting 1, Acti-vi-ty 27 The cle-a-ran-ce of an a-rea of ...
Purpose: Oncogene mutations contribute to colorectal cancer development. We searched for differences in oncogene mutation profiles between colorectal cancer metastases from different sites and evaluated these as markers for site of relapse. Experimental Design: One-hundred colorectal cancer metastases were screened for mutations in 19 oncogenes, and further 61 metastases and 87 matched primary cancers were analyzed for genes with identified mutations. Mutation prevalence was compared between (a) metastases from liver (n=65), lung (n=50) and brain (n=46), (b) metastases and matched primary cancers, and (c) metastases and an independent cohort of primary cancers (n=604). Mutations differing between metastasis sites were evaluated as markers for site of relapse in 859 patients from the VICTOR trial. Results: In colorectal cancer metastases, mutations were detected in 4 of 19 oncogenes: BRAF (3.1%), KRAS (48.4%), NRAS (6.2%) and PIK3CA (16.1%). KRAS mutation prevalence was significantly higher in ...
Conclusion. Results of our study show that synchronous hepatic metastases of colorectal cancers are less frequently observed in chronic HBV or HCV infected patients than in non infected patients, while the incidence of extrahepatic metastases is comparable in both groups, suggesting that virus-related mechanisms and specific liver mediated immunity may have a protective role against neoplastic cell colonization of the liver.. ...
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Rudolf Steiner Archive: Gospel of St. John: Lecture XII - The decline of the ancient wisdom and its renewal through the Christ-impulse. The significance of the Mystery of Golgotha for human evolution upon earth.
The real challenge to come is to acquire SIM cards for our data "dongles" in order to avoid the rip-off rates charged for data roaming. It will be interesting to see whether the various French telcos and mobile operators still persist in their bizarre policy of allowing you to top up your account in a shop using a credit card but will not allow you to use the same card for the same purpose on-line (unless its a French card of course). Perhaps M. Hollande will sort it out when hes finished dealing with Angela ...
Chondromyxoid fibroma is a rare benign tumor of cartilaginous origin with myxoid and fibrous components. It accounts for approximately 1% of bone tumors. Metaphysis of long bones is the most common location of this tumor. However, there a few case reports of this tumor arising from epiphysis of short tubular bones of the hand and feet. An 11-year-old girl presented to our OPD with complaints of pain and a gradually progressive swelling of the right great toe. On examination, the swelling was diffuse with no signs of inflammation. X-ray examination revealed a well-defined, longitudinally oval lytic lesion in the right distal phalanx of great toe, involving the growth plate and, eroding the medial cortex. Computed tomography (CT) scan did not show any evidence of calcification, septations or involvement of soft tissue. Open biopsy and curettage was done and the specimen was sent for histopathological examination. Histopathological examination (HPE) showed a lobular pattern consisting of myxomatous
UniProtKB/Swiss-Prot : 74 Osteogenesis imperfecta 12: A form of osteogenesis imperfecta, a connective tissue disorder characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI12 is an autosomal recessive form characterized by recurrent fractures, mild bone deformations, generalized osteoporosis, delayed teeth eruption, no dentinogenesis imperfecta, normal hearing, and white sclerae ...
Looking for online definition of Ehlers-Danlos-like syndrome due to tenascin-X deficiency in the Medical Dictionary? Ehlers-Danlos-like syndrome due to tenascin-X deficiency explanation free. What is Ehlers-Danlos-like syndrome due to tenascin-X deficiency? Meaning of Ehlers-Danlos-like syndrome due to tenascin-X deficiency medical term. What does Ehlers-Danlos-like syndrome due to tenascin-X deficiency mean?
α). With acc.: ut faber, cum quid aedificaturus est, non ipse facit materiam, sed ea utitur, quae sit parata, etc. ... Quod si non est a deo materia facta, ne terra quidem et aqua et aër et ignis a deo factus est, Cic. N. D. Fragm. ap. Lact. 2, 8 (Cic. ed. Bait. 7, p. 121): "sphaera ab Archimede facta," Cic. Rep. 1, 14: "fecitque idem et sepsit de manubiis comitium et curiam," id. ib. 2, 17: "aedem," id. ib. 2, 20: "pontem in Arari faciundum curat," Caes. B. G. 1, 13, 1: "castra," id. ib. 1, 48, 2; Cic. Fam. 15, 4, 4: "faber vasculum fecit," Quint. 7, 10, 9: "classem," Caes. B. G. 4, 21, 4: "cenas et facere et obire," Cic. Att. 9, 13, 6: "ignem lignis viridibus," Cic. Verr. 2, 1, 17, § 45: "poëma," to compose, id. Pis. 29, 70: "carmina," Juv. 7, 28: "versus," id. 7, 38: "sermonem," Cic. Fam. 9, 8, 1; cf. "litteram," id. Ac. 2, 2, 6: ludos, to celebrate, exhibit = edere, id. Rep. 2, 20; id. Att. 15, 10; "also i. q. ludificari," Plaut. Capt. 3, 4, 47: "sementes," i. e. to sow, Caes. B. G. 1, ...
That in order to enforce this Order and responsibility, I, Kevin Annett Eagle Strong Voice, will publicly deputize any and all members of the Vancouver police department and the RCMP to enforce this legal order, as is their duty and obligation under common law, and that any refusal by them to do so, or any attempt by them to prevent me or my agents from enforcing this Order, will be considered an act of hostile intent and criminality by them, and a violation of their oath of office. In the event of such a dereliction of duty on the part of these police officers, I reserve my right under common law and Siem Kiapilanos original authorization to appoint Public Peace Officers to maintain the peace and enforce this lawful Order according to the principle Actus legis nemini facit injuriam, The act of the law does no one an injury ...
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TY - JOUR. T1 - Frequent expression of fibroblast growth factor-23 (FGF23) mRNA in aneurysmal bone cysts and chondromyxoid fibromas. AU - Graham, Rondell. AU - Krishnamurthy, Smita. AU - Oliveira, Andre. AU - Inwards, Carrie. AU - Folpe, Andrew L.. PY - 2012/10/1. Y1 - 2012/10/1. N2 - Osteomalacia has multiple aetiologies including the least common, tumour-induced osteomalacia (TIO). Recently, most cases of TIO have been confirmed to be due to phosphaturic mesenchymal tumour of mixed connective tissue type (PMTMCT). Most cases of TIO are the result of production of the fibroblast growth factor-23 (FGF-23) by the tumour. The authors recently showed reverse transcriptase PCR (RT-PCR) for FGF-23 to be valuable in the diagnosis of PMTMCT. However, the authors also noted FGF-23 expression in some cases of aneurysmal bone cyst (ABC) and chondromyxoid fibroma (CMF). For the present study, the authors studied FGF-23 expression by RT-PCR in 19 cases of ABC and eight cases of CMF, all with typical ...
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This thesis consists of three essays investigating different aspects of interest rates.. "Prediction of Future Risk-Neutral Short-Term Interest Rate Densities: Can the Black, Derman and Toy Model Assist?" (Co-authored with David Vestin.) This essay evaluates two different approaches to inferring expectations of future interest rates from asset prices. One is based on bond data and builds on the Black, Derman and Toy model, the other is based on option prices. We compare the outcome with a specified assumed benchmark data generating process. The main conclusion is that the option based model works well, whereas the bond based model has difficulties in capturing aspects of the true distribution.. "Natura non facit saltum - Or Are Jumps an Inherent Feature in European Interest Rate Markets?" A jump-enhanced diffusion model for the instantaneous interest rate is estimated on the EURIBOR, LIBOR and STIBOR one-week interest rates via the characteristic function and a Fourier transform to recover the ...
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France - The age of Louis XIV: Throughout his long reign Louis XIV (1643-1715) never lost the hold over his people he had assumed at the beginning. He worked hard to project his authority in the splendid setting of Versailles and to depict it in his arrogant motto
1 Corinthians chapter 12, verse 1 and 1 Corinthians chapter 12, verse 2Now concerning spiritual gifts, brethren, I would not have you ignorant. Ye know that when ye were Gentiles, ye were led away unto those dumb idols, howsoever ye might be led.. This whole place is very obscure: but the obscurity is produced by our ignorance of the facts referred to and by their cessation, being such as then used to occur but now no longer take place. And why do they not happen now?Why look now, the cause too of the obscurity hath produced us again another question: namely, why did they then happen, and now do so no more?. This however let us defer to another time, but for the present let us state what things were occurring then. Well: what did happen then? Whoever was baptized he straightway spake with tongues and not with tongues only, but many also prophesied, and some also performed many other wonderful works. For since on their coming over from idols, without any clear knowledge or training in the ancient ...
1. In describing the nerves and their functions, it will be necessary to classify them, or to reduce them to such arrangement, as the present state of our knowledge on the subject will admit. The foll...
It appears that we will announce one (possibly two) more bands for the main location (Edison) sometime in December. Neither band will be a huge headliner, but will be a nice way to round things out. One band in particular would represent a country that has never been represented before at MDF, and were currently waiting to make sure that they can make it into the US before announcing them ...
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March 14, 2001 - Number of Comments » 0. Le Jardin de Peyrou with the statue of Louix XIV and the Porte de Peyrou in the background. ...
Anti mouse factor XII, clone 2A6 - Strongly detects mouse Factor XII, mildly detects human Factor XII and XIIa, and strongly detects human Factor beta-XIIa.
Quicunque tribuit sibi bonum quod facit, etiamsi nihil videtur mali manibus operari, jam cordis innocentiam perdidit, in quo se largitori bonorum prætulit." - Hieron. in Prov. cap. xvi. Neither is this impotency, although absolutely and naturally insuperable, and although it have in it also the nature of a punishment, any excuse or alleviation of the sin of men when they receive not spiritual things as proposed unto them; for although it be our misery, it is our sin; - it is the misery of our persons, and the sin of our natures. As by it there is an unconformity in our minds to the mind of God, it is our sin; as it is a consequent of the corruption of our nature by the fall, it is an effect of sin; and as it exposeth us unto all the ensuing evil of sin and unbelief, it is both the punishment and cause of sin. And no man can plead his sin or fault as an excuse of another sin in any kind. This impotency is natural, because it consists in the deprivation of the light and power that were originally ...
Anti mouse factor XII, clone 23E10 - Epitope localized to the light chain. Detects Factor XII, Factor XIIa and Factor beta-XIIa under non-reducing and reducing conditions.
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İçindekiler ÖZET................................................................................................................................. i. ABSTRACT..................................................................................................................... ii. TEŞEKKÜR..................................................................................................................... iii. SİMGELER DİZİNİ....................................................................................................... viii. ŞEKİLLER DİZİNİ......................................................................................................... ix. ÇİZELGELER DİZİNİ.................................................................................................. xii. 1.GİRİŞ.............................................................................................................................. 1. 2. KURAMSAL ...
The standard of care of care for metastatic CRC confined to the liver is surgical resection; however, most patients are not surgical candidates due to patient and tumor characteristics. Liver-directed therapy is an option for many of these patients whose liver metastases are unresectable. There is uncertainty surrounding the optimal use of the various local therapies in these settings. This topic is clinically relevant and one of importance to health care providers, patients, and policymakers.. Patients with unresectable liver metastasis are a heterogeneous group, in which careful patient selection may offer opportunities for successful treatment. Patient-selection criteria are a key issue, in particular the definition of medically or technically inoperable patients.24 All patients in our review will have been classified as having unresectable disease, either due to the extent of the tumor or patient characteristics (poor surgical candidate). Our review will include two distinct patient ...
The Pope (Pius XII and Leo XIII) Speaks on Rural Life Speech delivered by His Holiness, Pope Pius XII, to the delegates at the Convention of the National Confederation of Farm Owner-Operators. Also a section from Pope Leo XIIIs encyclical Rerum Novarum on the Values of Land Ownership. Compiled by the National Catholic Rural Life Conference.
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i) express this in percent by mass (ii) determine the molality of chloroform in the water sample. Question12:State Henrys law and mention some important applications? Question13:The partial pressure of ethane over a solution containing 6.56 × 10−3 g of ethane is 1 bar. ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... Collagen, type I, alpha 1 (COL1A1) Collagen, type II, alpha 1 (COL2A1) Collagen, type III, alpha 1 (COL3A1) Collagen, type V, ... collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of VWA-containing proteins are ... "Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins". ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of VWA-containing proteins are ... Colombatti A, Bonaldo P, Doliana R (1993). "Type A modules: interacting domains found in several non-fibrillar collagens and in ... Perkins SJ, Edwards YJ (1995). "The protein fold of the von Willebrand factor type A domain is predicted to be similar to the ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of VWF-containing proteins are ... Colombatti A, Bonaldo P, Doliana R (July 1993). "Type A modules: interacting domains found in several non-fibrillar collagens ... the vWF type D domain in particular, is a large, multimeric glycoprotein and it is synthesized by a type of bone marrow cell ...
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C- ... Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen".[citation needed] Collagen IV ... type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 ... Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase?". Alcoholism: ...
Each type of connective tissue in animals has a type of ECM: collagen fibers and bone mineral comprise the ECM of bone tissue; ... Fibrillar (Type I, II, III, V, XI). *Facit (Type IX, XII, XIV) ... CollagenEdit. Collagens are the most abundant protein in the ... Other (Type VI, VII, XIII). ElastinEdit. Elastins, in contrast to collagens, give elasticity to tissues, allowing them to ... Karsenty G, Park RW (1995). "Regulation of type I collagen genes expression". International Reviews of Immunology. 12 (2-4): ...
The COL2A1 gene results in malformed type II collagen, which is essential in the transition from collagen to bone. This is the ... The COL2A1 gene is responsible for producing type II collagen. The mutation of COL2A1 gene leads to abnormal skeletal growth ... Hypochondrogenesis is caused when type II collagen is abnormally formed due to a mutation in the COL2A1 gene. Normally, the ... or Metatrophic Dwarfism Type II. Because collagen plays an important role in the development of the body, people with Kniest ...
Each type of connective tissue in animals has a type of ECM: collagen fibers and bone mineral comprise the ECM of bone tissue; ... Fibrillar (Type I, II, III, V, XI). *Facit (Type IX, XII, XIV) ... Collagen[edit]. Collagens are the most abundant protein in the ... Other (Type VI, VII, XIII). Elastin[edit]. Elastins, in contrast to collagens, give elasticity to tissues, allowing them to ... Laminins bind other ECM components such as collagens and nidogens.[9] Development[edit]. There are many cell types that ...
Collagenopathy, types II and XI XII. FACIT collagen, interacts with type I containing fibrils, decorin and glycosaminoglycans. ... TypesEdit. Collagen occurs in many places throughout the body. Over 90% of the collagen in the human body, however, is type I.[ ... Multiple collagen fibrils form into collagen fibers.. *Collagen may be attached to cell membranes via several types of protein ... With type I collagen and possibly all fibrillar collagens, if not all collagens, each triple-helix associates into a right- ...
Fibril Associated Collagens with Interrupted Triple Helices) (Type IX, XII, XIV, XIX, XXI) Short chain (Type VIII, X) Basement ... With type I collagen and possibly all fibrillar collagens, if not all collagens, each triple-helix associates into a right- ... Multiple collagen fibrils form into collagen fibers. Collagen may be attached to cell membranes via several types of protein, ... Over 90% of the collagen in the human body, however, is type I. So far, 28 types of collagen have been identified and described ...
Collagen, type I, alpha 1 Collagen, type II, alpha 1 Collagen, type III, alpha 1 Collagen, type IV, alpha 1 Collagen, type V, ... type VI, alpha 1 Collagen, type VII, alpha 1 Collagen, type VIII, alpha 1 Collagen, type IX, alpha 1 Collagen, type X, alpha 1 ... collagen (type I, II, VI, X collagen fibrils) and proteoglycans. The ratio and the proportion of collagen play an important ... "Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen". Cell and ...
... is a type of collagen which is also a proteoglycan. FACIT collagens include collagen types IX, XII, XIV, XIX, and XXI. COL22A1 ... GO term: FACIT collagen FACIT - Collagens which are proteoglycnas Fitzgerald J, Bateman J (2001). "A new FACIT of the collagen ... Tuckwell D (2002). "Identification and analysis of collagen alpha 1(XXI), a novel member of the FACIT collagen family". Matrix ... FACIT collagen (Fibril Associated Collagens with Interrupted Triple helices) ...
... of which is collagen type 1 and the remaining 10% ground substance, which includes dentine-specific proteins), and 10% water ( ... TypesEdit. There are three types of dentin, primary, secondary and tertiary.[13][14] Secondary dentin is a layer of dentin ... It is of two types, either reactionary, where dentin is formed from a pre-existing odontoblast, or reparative, where newly ... It is unmineralized and consists of collagen, glycoproteins and proteoglycans. It is similar to osteoid in bone and is thickest ...
Leitinger B, Kwan AP (2006). "The discoidin domain receptor DDR2 is a receptor for type X collagen". Matrix Biol. 25 (6): 355- ... protein tyrosine kinase collagen receptor activity. • protein tyrosine kinase activity. • ATP binding. • collagen binding. ... collagen-activated tyrosine kinase receptor signaling pathway. • ossification. • phosphorylation. • collagen fibril ... "Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen". J. Biol. Chem. 277 (21): ...
This gene is in between COL2A1, the human type II collagen gene, and VDR, the human Vitamin D Receptor gene. This protein is ... It can be found expressed in many tissues types. Tissue types with high expression included the adrenal gland, eye, ... Krogh, Anders (12 Jun 2013). "TMHMM Server v 2.0". Tusnady, G.E. (2001). "HMMTop: Prediction of transmembrane helices and ... This gene spans from 48357225 to 48362667 on chromosome 12. ...
Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. ... "Entrez Gene: COL9A3 collagen, type IX, alpha 3". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...
Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, a collagen component of hyaline cartilage. ... "Entrez Gene: COL9A1 collagen, type IX, alpha 1". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...
... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... GeneReview/NCBI/NIH/UW entry on Ehlers-Danlos Syndrome Type IV Collagen type III at the US National Library of Medicine Medical ... COL3A1 collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)". ... Type-III collagen is a fibrous scleroprotein in bone, cartilage, dentin, tendon, bone marrow stroma and other connective tissue ...
... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. ... the structure of type I collagen is compromised. Tissues that are rich in type I collagen, such as the skin, bones, and tendons ... Ehlers-Danlos type IV is most attributed to abnormalities in the reticular fibers (collagen Type III). Ehlers-Danlos syndrome, ...
... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ... "Entrez Gene: COL5A3 collagen, type V, alpha 3". van der Rest M, Garrone R (1991). "Collagen family of proteins". FASEB J. 5 (13 ...
This protein is an alpha chain of type VI collagen that aids in microfibril formation. As part of type VI collagen, this ... This gene encodes the alpha 3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in ... "The 1.6 A structure of Kunitz-type domain from the alpha 3 chain of human type VI collagen". Journal of Molecular Biology. 246 ... "Anisotropic behaviour of the C-terminal Kunitz-type domain of the alpha3 chain of human type VI collagen at atomic resolution ( ...
... chain of type II collagen. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and ... "A COL2A1 mutation in achondrogenesis type II results in the replacement of type II collagen by type I and III collagens in ... type 2 by affecting tissues that are rich in type II collagen. Platyspondylic lethal skeletal dysplasia, Torrance type:Fewer ... chain that cannot be incorporated into type II collagen fibers. As a result, cells make a reduced amount of type II collagen. ...
XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". ... This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with ... other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve ... "Entrez Gene: COL19A1 collagen, type XIX, alpha 1". Yoshioka H, Zhang H, Ramirez F, et al. (1992). "Synteny between the loci for ...
2005). "Collagen types XII and XIV are present in basement membrane zones during human embryonic development". J. Mol. Histol. ... "Entrez Gene: COL14A1 collagen, type XIV, alpha 1 (undulin)". Schuppan D, Cantaluppi MC, Becker J, et al. (1990). "Undulin, an ... Tono-Oka S, Tanase S, Miike T, Tanaka H (1996). "Transient expression of collagen type XIV during muscle development and its ... Bauer M, Dieterich W, Ehnis T, Schuppan D (Jan 1998). "Complete primary structure of human collagen type XIV (undulin)". ...
It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of the type IV collagen and plays a role in ... collagen". FEBS Letters. 225 (1-2): 188-94. doi:10.1016/0014-5793(87)81155-9. PMID 3691802. "Entrez Gene: COL4A1 collagen, type ... Type IV collagen is the major structural component of basement membranes, which contains two or three COL4A1 proteins. Thus, ... COL4A1 belongs to the type IV collagen family and contains three domains: a short N-terminal domain, a long triple-helical 7S ...
... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... "Entrez Gene: COL5A2 collagen, type V, alpha 2". Mann K (1992). "Isolation of the alpha 3-chain of human type V collagen and ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ...
Atrophic acne scars have lost collagen from the healing response and are the most common type of acne scar (account for ... acne generally improves between eight and twelve weeks after starting therapy.[15] ... microspheres with collagen; human and bovine collagen derivatives, and fat harvested from the person's own body (autologous fat ... Many over-the-counter treatments in many forms are available, which are often known as cosmeceuticals.[168] Certain types of ...
... collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to ... type XII, alpha 1". Oh SP, Taylor RW, Gerecke DR, et al. (1992). "The mouse alpha 1(XII) and human alpha 1(XII)-like collagen ... This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted ... XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". ...
Collagen degradation (Homo sapiens) * Collagen type XII degradation by MMP12 (Homo sapiens) * Cleaved collagen type XII [ ... Cleaved collagen type XII [extracellular region] (Danio rerio) Cleaved collagen type XII [extracellular region] (Gallus gallus) ... Cleaved collagen type XII [extracellular region] (Bos taurus) Cleaved collagen type XII [extracellular region] (Canis ... Cleaved collagen type XII [extracellular region] (Mus musculus) Cleaved collagen type XII [extracellular region] (Rattus ...
Collagen types XII and XIV belong to a subgroup of... ... The collagens constitute a large group of proteins in the ... Collagen types XII and XIV belong to a subgroup of non-fibrillar-collagens termed (fibril-associated collagens with interrupted ... collagen type-XII was present in the basement membrane zones of epithelia and endothelia. However, collagen type-XIV was ... RE 1991Two type XII-like collagens localize to the surface of banded collagen fibrilsJ Cell Biol113971978Google Scholar ...
... type XII collagen could be associated with a disorganized collagen fiber arrangement. 22 Thus, type XII collagen could also ... Recently, using type XII collagen-null mice, it was demonstrated that type XII collagen could be involved in bone formation and ... Unwounded cornea expressed a low level of type XII collagen (Fig. 7B). At D7 after injury, type XII collagen staining was ... The next steps will concern the functional analysis of type XII collagen using mice deficient for collagen XII. Targeting type ...
... collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to ... Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of ... This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted ... collagen type XII alpha 1 chain. Enable Javascript to view the expand/collapse boxes.. Open All Close All ...
... is an eagle-i resource of type Hybridoma cell line at eagle-i Network Shared Resource Repository. ... mouse anti-collagen type XII hybridoma (MT2). eagle-i ID. http://shared.eagle-i.net/i/00000140-d7a4-ab3e-fa61-b3d480000000 ... mouse anti-collagen type XII hybridoma (MT2) ... Inferred Types from the eagle-i Ontology (What is an ontology?) ...
Niedbala W, Cai B, Wei X, Patakas A, Leung BP, McInnes IB et al. Interleukin-27 attenuates collagen-induced arthritis. Ann ... The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. J Clin Invest 2008;118:1680-1690. * ... Type I interferon in systemic lupus erythematosus and other autoimmune diseases. Immunity 2006;25:383-392. *CrossRef, ... Induction of type I diabetes by interferon-alpha in transgenic mice. Science 1993;260:1942-1946. *CrossRef, ...
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C- ... Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen".[citation needed] Collagen IV ... type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 ... Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase?". Alcoholism: ...
Fibronectin type-IIIInterPro annotation. ,p>Information which has been generated by the UniProtKB automatic annotation system, ... Collagen alpha-1(XII) chainImported. ,p>Information which has been imported from another database using automatic procedures.,/ ... tr,E9PX70,E9PX70_MOUSE Collagen alpha-1(XII) chain OS=Mus musculus OX=10090 GN=Col12a1 PE=1 SV=1 ... IPR008160 Collagen. IPR013320 ConA-like_dom_sf. IPR003961 FN3_dom. IPR036116 FN3_sf. IPR013783 Ig-like_fold. IPR001791 Laminin_ ...
Fibronectin type-IIIInterPro annotation. Automatic assertion inferred from signature matchi ... Collagen alpha-1(XII) chainImported. ,p>Information which has been imported from another database using automatic procedures.,/ ... tr,A0A087X0A8,A0A087X0A8_HUMAN Collagen alpha-1(XII) chain OS=Homo sapiens OX=9606 GN=COL12A1 PE=1 SV=1 ... IPR008160 Collagen. IPR013320 ConA-like_dom_sf. IPR003961 FN3_dom. IPR036116 FN3_sf. IPR013783 Ig-like_fold. IPR001791 Laminin_ ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions.. J. ... Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions.. J. ... Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins.. ... Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins.. ...
... and Collagen Type I Degradation Products With the Remodeling of the Left Ventricle in Patients With Acute Myocardial Infarction ... content of C-terminal telopeptide of collagen type I degradation products (ICTP) was measured by chemiluminescent immunoassay. ... In this work we revealed association of A allele of MMP20 rs2245803 with formation of dilative type of LV remodeling and ... Significant association was found between A allele of MMP 20 rs2245803 and dilation type of LV remodeling (odds ratio [OR] 2.82 ...
... is a type of collagen which is also a proteoglycan. FACIT collagens include collagen types IX, XII, XIV, XIX, and XXI. COL22A1 ... GO term: FACIT collagen FACIT - Collagens which are proteoglycnas Fitzgerald J, Bateman J (2001). "A new FACIT of the collagen ... Tuckwell D (2002). "Identification and analysis of collagen alpha 1(XXI), a novel member of the FACIT collagen family". Matrix ... FACIT collagen (Fibril Associated Collagens with Interrupted Triple helices) ...
Type XII collagen regulates osteoblast polarity and communication during bone formation.. Izu Y, Sun M, Zwolanek D, Veit G, ... Type XIV Collagen Regulates Fibrillogenesis: PREMATURE COLLAGEN FIBRIL GROWTH AND TISSUE DYSFUNCTION IN NULL MICE. ... Expression of type XXIII collagen mRNA and protein.. Koch M, Veit G, Stricker S, Bhatt P, Kutsch S, Zhou P, Reinders E, Hahn RA ... Collagen XII interacts with avian tenascin-X through its NC3 domain.. Veit G, Hansen U, Keene DR, Bruckner P, Chiquet-Ehrismann ...
The purified mass is dried to provide the desired Type I collagen product which may be ground into a powder or formed into a ... The enzyme-treated comminuted material which is rich in collagen is dispersed in an organic acid to cause the fibrillar mass to ... source such as poultry feet that incorporates a fibrillar mass of connective tissue as well as bony tissue to yield a collagen ... collagen matrix or sponge, depending on the end use therefor. ... A process for extracting type I collagen from an avian ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... Collagen, type I, alpha 1 (COL1A1) Collagen, type II, alpha 1 (COL2A1) Collagen, type III, alpha 1 (COL3A1) Collagen, type V, ... collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of VWA-containing proteins are ... "Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins". ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of VWA-containing proteins are ... Colombatti A, Bonaldo P, Doliana R (1993). "Type A modules: interacting domains found in several non-fibrillar collagens and in ... Perkins SJ, Edwards YJ (1995). "The protein fold of the von Willebrand factor type A domain is predicted to be similar to the ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of VWF-containing proteins are ... Colombatti A, Bonaldo P, Doliana R (July 1993). "Type A modules: interacting domains found in several non-fibrillar collagens ... the vWF type D domain in particular, is a large, multimeric glycoprotein and it is synthesized by a type of bone marrow cell ...
Molecular mechanisms for OI types I-IV are mutations in type 1 collagen genes COLA1 and COLA2. Types V-XII are rarer forms. ... Mutations in type II collagen cause a large number of disorders classified as spondyloepiphyseal dysplasia (ie, ... Infant with Beemer-type (left) and an infant with Majewski-type (right) short-rib syndrome (SRS). Note severe micrognathia/ ... Infant with Beemer-type (left) and an infant with Majewski-type (right) short-rib syndrome (SRS). Note severe micrognathia/ ...
Collagen type XI alpha 1 chain. COL12A1. Collagen type XII alpha 1 chain ... slow type MYBPC1, troponin T1, slow skeletal type TNNT1, tropomodulin 4 TMOD4, leiomodin 3 LMOD3 and myosin light chain 10 ... Induction of alveolar type-II cell-differentiation in fetal tracheal epithelium by grafted distal lung mesenchyme. Dev Biol. ... The lung contains about 40 cell types and myofibroblasts represent 10% of mature lung cells. As the normal rate of regeneration ...
col12a1: collagen, type XII, alpha 1. 0.9. 0.3. 2.0. 2.0. EEMP1: EGF-containing fibulin-like extracellular matrix protein 1. 49 ... Collagen catabolism. 2.1. 0.4. None. None. mmp13: matrix metalloproteinase 13. 1. 1.1. 1.1. 3.2. 2.8. TIMP3: tissue inhibitor ... col6a3: procollagen, type VI, alpha 3. 86. 2.4. 0.8. None. None. ... VCIP: VEGF and type I collagen inducible protein. 42. Cell ...
... collagen type XII α 1 chain. ... Cancer type. Target gene. (Refs.). Mitra et al, 2012. miR-155. ... MicroRNAs (miRNAs/miRs) are an abundant type of endogenous small RNA molecule that downregulate target gene expression (24). A ... Using the peptidase inhibitor, PT-100 (talabostat) was revealed to reduce the tumor growth rate in numerous types of tumor ... BIBF1120 has been applied clinically for the treatment of several types of tumor (102). Taken together, these findings suggest ...
Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. Here the D is approximately 67 nm and ... These form the most abundant collagens in vertebrates. ... There are 29 genetically distinct collagens present in animal ... XII. FACIT collagen, interacts with type I containing fibrils, decorin and glycosaminoglycans. COL12A1. -. ... Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen ...
... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ... "Entrez Gene: COL5A3 collagen, type V, alpha 3". van der Rest M, Garrone R (1991). "Collagen family of proteins". FASEB J. 5 (13 ...
This protein is an alpha chain of type VI collagen that aids in microfibril formation. As part of type VI collagen, this ... This gene encodes the alpha 3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in ... "The 1.6 A structure of Kunitz-type domain from the alpha 3 chain of human type VI collagen". Journal of Molecular Biology. 246 ... "Anisotropic behaviour of the C-terminal Kunitz-type domain of the alpha3 chain of human type VI collagen at atomic resolution ( ...
  • C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins [ PMID: 15476922 ]. (ebi.ac.uk)
  • Endostatin [ PMID: 9724722 ] and the endostatin domain of collagen alpha 1 (XV) [ PMID: 966814 ], these domains being decorated with many insertions in the common fold. (ebi.ac.uk)
  • The noncollagenous (NC1) domain of collagen IV, which consists of a duplication of the C-type lectin domain, with segment swapping within and between individual domains [ PMID: 12011424 ]. (ebi.ac.uk)
  • Gelatin , which is used in food and industry, is collagen that has been irreversibly hydrolyzed . (wikipedia.org)
  • Gelatin or gelatine (from Latin: gelatus meaning "stiff", "frozen") is a translucent, colorless, brittle (when dry), flavorless food derived from collagen obtained from various animal body parts. (wikipedia.org)
  • While many processes exist whereby collagen may be converted to gelatin, they all have several factors in common. (wikipedia.org)
  • This enzyme catalyses the following chemical reaction Cleavage of gelatin types I and V and collagen types IV and V This enzyme is similar to gelatinase A, but possesses a further domain. (wikipedia.org)
  • Collagen Reticular fiber Ehlers-Danlos syndrome Kuivaniemi H, Tromp G, Prockop DJ (1991). (wikipedia.org)
  • Jaeger E, Rust S, Roessner A, Kleinhans G, Buchholz B, Althaus M, Rauterberg J, Gerlach U (1991) Joint occurrence of collagen mRNA containing cells and macrophages in human atherosclerotic vessels. (springer.com)
  • Alternative splice variants of the NC3 and NC1 domains of type XII collagen were investigated in the mouse wound-healing model using RT-PCR. (arvojournals.org)
  • Ullrich congenital muscular dystrophy is a form of congenital muscular dystrophy.It is associated with variants of type VI collagen, it is commonly associated with muscle weakness and respiratory problems, though cardiac issues are not associated with this type of CMD. (wikipedia.org)
  • Liver fibrosis and cirrhosis are associated with the deposition of collagen IV in the liver. (wikipedia.org)
  • Increased glomerular and mesangial deposition of collagen IV occurs in diabetic nephropathy and increased urinary levels are associated with the extent of renal injury. (wikipedia.org)
  • In addition to the above mentioned disorders, excessive deposition of collagen occurs in scleroderma. (news-medical.net)
  • IPF is believed to be the result of an aberrant wound healing process including/involving abnormal and excessive deposition of collagen (fibrosis) in the pulmonary interstitium with minimal associated inflammation. (wikipedia.org)
  • Glycine, proline, alanine and hydroxyproline are some of the important amino acids provided by collagen I & III peptides and replenishing these amino acids helps to maintain collagen at healthy levels. (forresthealth.com)
  • Hydrolyzed collagen contains 19 amino acids, predominantly glycine, proline and hydroxyproline, which together represent around 50% of the total amino acid content. (wikipedia.org)
  • Hydrolyzed collagen contains 8 out of 9 essential amino acids, including glycine and arginine-two amino-acid precursors necessary for the biosynthesis of creatine. (wikipedia.org)
  • Glutaric acidemia type 1 (or "glutaric aciduria", "GA1", or "GAT1") is an inherited disorder in which the body is unable to completely break down the amino acids lysine, hydroxylysine and tryptophan. (wikipedia.org)
  • Collagen-related diseases most commonly arise from genetic defects or nutritional deficiencies that affect the biosynthesis, assembly, postranslational modification, secretion, or other processes involved in normal collagen production. (news-medical.net)
  • A platelet function assay may give an abnormal collagen/epinephrine closure time, and in most cases, a normal collagen/ADP time. (wikipedia.org)
  • Thirty healthy adult corneas and 10 corneas from 12-day- to 3-year-old children were studied by immunofluorescence with antibodies against BM components. (arvojournals.org)
  • We describe Western immunoblotting of intact α1(I) collagen using antibodies directed to α1(I) collagen amino and carboxyl propeptides. (springer.com)
  • Immunohistochemical analysis using collagen type-specific antibodies. (springer.com)
  • They are also referred to as anti-DNA topoisomerase I antibody (anti-topo I). Anti Scl-70 antibodies (also called anti-topoisomerase I after the type I topoisomerase target) is a type of anti-nuclear autoantibody seen mainly in diffuse systemic scleroderma, but is also seen the more limited form of systemic scleroderma called CREST syndrome. (wikipedia.org)
  • Known aliases for PRR12 include "proline rich 12" and KIAA1205. (wikipedia.org)
  • PRR12 is not only proline rich, but it is also rich in glycine, suggesting that there might be a relationship to collagen which is also proline and glycine rich. (wikipedia.org)
  • Type V: cell surfaces, hair and placenta The collagenous cardiac skeleton which includes the four heart valve rings, is histologically, elastically and uniquely bound to cardiac muscle. (wikipedia.org)