A fibril-associated collagen found in many tissues bearing high tensile stress, such as TENDONS and LIGAMENTS. It is comprised of a trimer of three identical alpha1(XII) chains.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
Developmental bone diseases are a category of skeletal disorders that arise from disturbances in the normal growth and development of bones, including abnormalities in size, shape, structure, or composition, which can lead to various musculoskeletal impairments and deformities.
A genetic or pathological condition that is characterized by short stature and undersize. Abnormal skeletal growth usually results in an adult who is significantly below the average height.
Abnormal development of cartilage and bone.
Congenital structural abnormalities and deformities of the musculoskeletal system.
An autosomal dominant disorder that is the most frequent form of short-limb dwarfism. Affected individuals exhibit short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and mid-face hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, GENU VARUM, and trident hand. (Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim, MIM#100800, April 20, 2001)
A severe form of neonatal dwarfism with very short limbs. All cases have died at birth or later in the neonatal period.
Deviations from the average values for a specific age and sex in any or all of the following: height, weight, skeletal proportions, osseous development, or maturation of features. Included here are both acceleration and retardation of growth.

Tensile stress-dependent collagen XII and fibronectin production by fibroblasts requires separate pathways. (1/14)

The intracellular mechanisms controlling mechano-dependent production of the two extracellular matrix proteins collagen XII and fibronectin were analyzed. Fibroblasts were cultured on either tensed (attached) or released (floating) collagen type-I gels, respectively. Collagen XII and fibronectin production was three- to fivefold higher under tensed than under released conditions. The general inhibitor of tyrosine phosphorylation, genistein (50 microM), and the MAP kinase inhibitor PD98059 (20 microM) selectively reduced collagen XII accumulation by tensed cultures. Addition of PD98059, but not genistein, downregulated tensile stress-induced tyrosine phosphorylation levels of ERK1/2 and focal adhesion kinase. Staurosporine as well as pretreatment with phorbol ester, which constitute means to downregulate classical and novel PKC activity, specifically blocked collagen XII but not fibronectin accumulation in tensed fibroblasts. ERK1/2 phosphorylation levels were not affected by staurosporine treatment. Chronic exposure to the protein kinase C inhibitors bisindolylmaleimide and calphostin C blocked increased production of both fibronectin and collagen XII from cells under tension. The data manifest that the mechano-dependent production of collagen XII and fibronectin requires separate pathways. The FAK-ERK1/2 pathway, a genistein-sensitive tyrosine kinase, and a distinct classical/novel PKC appear selectively required for increased production of collagen XII in cells under tensile stress, whereas fibronectin induction is regulated by a different PKC-dependent pathway.  (+info)

Differential expression of type XII collagen in developing chicken metatarsal tendons. (2/14)

Type XII collagen is a fibril-associated collagen with multiple functional domains. The purpose of this work was to determine its role in regulating tendon matrix assembly. The temporal and spatial expression patterns of both collagen and mRNA were analysed in developing chicken metatarsal tendons using immunofluorescence microscopy, in situ hybridization and real-time quantitative PCR. Temporally, type XII collagen was present during all stages of development (day 14-hatch). However, spatially, type XII collagen expression shifted from the entire tendon at day 14, when the tendon is immature and fascicles are not well developed, to the interfacial matrix (endotendinium) associated with developing fascicles. This shift was obvious beginning at day 17, becoming prominent at day 19. Associated with this shift was a gradual decrease in type XII collagen reactivity in the tendon proper (non-sheath). By hatching, the reactivity was sequestered almost exclusively to the sheaths with some reactivity remaining at the fibroblast-matrix interface within the fascicle. In situ hybridization indicated that fibroblasts in the tendon expressed type XII collagen mRNA homogeneously at day 14. However, by hatching, when the tendon matures, type XII collagen is restricted primarily to the sheath cells. Quantitative PCR analyses, of NC3 splice variants, demonstrated highest expression levels for the short splice variant mRNA at days 14-17, followed by a significant decrease at day 19 with levels remaining constant to adult. Long variant mRNA expression was highest at day 14 then decreased and was constant from day 17 to adult. These changing patterns may be related to the spatial shift in type XII collagen expression to the sheaths. Differential temporal and spatial expression patterns indicate that type XII collagen functions to integrate the developing tendon matrices and fascicles into a functional unit.  (+info)

Expression of FACIT collagens XII and XIV during bleomycin-induced pulmonary fibrosis in mice. (3/14)

Collagens XII and XIV are members of a subfamily of fibril-associated collagens with interrupted triple-helices (FACITs) that facilitate the interactions of adjacent collagen fibrils. Using immunohistochemistry and in situ hybridization, we analyzed the spatial and temporal expression pattern of collagens XII and XIV during bleomycin-induced pulmonary fibrosis. C57Bl mice were treated with bleomycin (1 U, i.p., every other day for 8 days) or saline (control), and lung tissue samples were analyzed 2-12 weeks later. Collagen I protein expression was increased in the lung 2 weeks post bleomycin treatment and persisted for at least 12 weeks. In contrast, collagen XII and XIV expression was low until 4 weeks after bleomycin treatment. Whereas collagen XII expression was greatest between 4 weeks and 8 weeks, expression of collagen XIV persisted from 4 to 12 weeks, which suggests that these two proteins may play distinct roles in the fibrotic process. The mRNA for lysyl oxidase (LOX), an enzyme for cross-linking of collagens, had a delayed increase in the lung after bleomycin administration. It reached a maximum after 8 weeks, and persisted throughout the 12 weeks of the study. These data support the hypothesis that fibrosis is a multistep process that involves both collagen accumulation and changes in the molecules that modulate the biomechanical properties of fibrils.  (+info)

Collagen XII interacts with avian tenascin-X through its NC3 domain. (4/14)

Large oligomeric proteins often contain several binding sites for different molecules and can therefore induce formation of larger protein complexes. Collagen XII, a multidomain protein with a small collagenous region, interacts with fibrillar collagens through its C-terminal region. However, no interactions to other extracellular proteins have been identified involving the non-collagenous N-terminal NC3 domain. To further elucidate the components of protein complexes present close to collagen fibrils, different extracellular matrix proteins were tested for interaction in a solid phase assay. Binding to the NC3 domain of collagen XII was found for the avian homologue of tenascin-X that in humans is linked to Ehlers-Danlos disease. The binding was further characterized by surface plasmon resonance spectroscopy and supported by immunohistochemical co-localization in chick and mouse tissue. On the ultrastructural level, detection of collagen XII and tenascin-X by immunogold labeling confirmed this finding.  (+info)

Extracellular matrix gene alternative splicing by trabecular meshwork cells in response to mechanical stretching. (5/14)

PURPOSE: Elevated intraocular pressure (IOP), sensed as mechanical stretching by trabecular meshwork (TM) cells, triggers extracellular matrix (ECM) remodeling. In addition to changes in gene expression, alternative mRNA splicing may alter ECM protein isoforms. Changes in mRNA expression and alternative splicing of four ECM molecules in response to mechanical stretching of TM cells were investigated. METHODS: Porcine TM cells were mechanically stretched for 12, 24, or 48 hours. RNA was isolated, and RT-PCR was performed with primers that flanked alternatively spliced domains. PCR products were identified by DNA sequencing. Quantitative RT-PCR (qRT-PCR) was performed with primers positioned within nonspliced and spliced regions of the genes. RESULTS: Total levels of tenascin C, collagen type XII, and CD44 mRNA were increased, whereas versican mRNA levels were decreased in response to the mechanical stretch. In addition, each of these genes expressed alternate mRNA isoforms. Transcripts containing the fibronectin type III domain D of tenascin C, the long NC3 isoform of collagen type XII, the V1 isoform of versican, and exons v7 and v8 of CD44 all increased in response to mechanical stretching. A novel isoform of collagen type XII was observed that resulted in deletion of two exons, a frameshift, and a premature stop codon. This isoform was expressed only by stretched TM cells. CONCLUSIONS: These alternative splicing events led to the modulation of potential GAG attachment sites and other ECM-binding motifs. These changes should affect TM cell-ECM and/or protein-protein interactions during the ECM remodeling that occurs coincident with homeostatic restoration of IOP to normal.  (+info)

Mechanical strain increases expression of type XII collagen in murine osteoblastic MC3T3-E1 cells. (6/14)

In adult mouse, the mRNA corresponding to the alpha1 chain of type XII collagen (alpha 1(XII)) is predominantly detected in the bone. Additionally, murine osteoblastic cells, MC3T3-E1, increased the mRNA level of alpha 1(XII) response to the mechanical strain in the stretch culture system. Cyclic stretch stress resulted in a threefold increase in mRNA level of alpha 1(XII) as compared to the control experiment in MC3T3-E1. Transient transfection assays employing a reporter construct, together with site-directed mutagenesis studies, suggested that the AP-1 binding site in the first exon of mouse alpha 1(XII) gene is important for stretch stress-mediated upregulation of alpha 1(XII) expression. Electrophoretic mobility shift assay and associated antibody supershift experiments showed that stretch stress promotes the binding of c-Jun and JunD. Further chromatin immunoprecipitation experiments confirmed the participation of these transcription factors in the region. Also, the exogenous induction of the dominant negative form of c-Jun canceled the effect of stretch stress on the stimulation of the alpha 1(XII) gene. Here, we reported a potential responsive element to the stretch stress in mouse alpha 1(XII) gene. These data will provide new information on the mechanical strain-mediated transcriptional control of alpha 1(XII)-mediated fibrillogenesis in the bone.  (+info)

Tibolone inhibits bone resorption without secondary positive effects on cartilage degradation. (7/14)

 (+info)

Aberrations of 6q13 mapped to the COL12A1 locus in chondromyxoid fibroma. (8/14)

 (+info)

Collagen type XII is a type of collagen that is found in the extracellular matrix of various tissues, including tendons, ligaments, and skin. It is a fibril-associated collagen that is closely associated with collagens type I and III. Collagen type XII has been shown to play a role in regulating the organization and diameter of collagen fibrils. Mutations in the gene for collagen type XII have been associated with certain types of muscular dystrophy and Bethlem myopathy, which are genetic disorders that affect muscle strength and tone. Additionally, it has been suggested to play a role in the development of osteoarthritis.

Collagen is the most abundant protein in the human body, and it is a major component of connective tissues such as tendons, ligaments, skin, and bones. Collagen provides structure and strength to these tissues and helps them to withstand stretching and tension. It is made up of long chains of amino acids, primarily glycine, proline, and hydroxyproline, which are arranged in a triple helix structure. There are at least 16 different types of collagen found in the body, each with slightly different structures and functions. Collagen is important for maintaining the integrity and health of tissues throughout the body, and it has been studied for its potential therapeutic uses in various medical conditions.

Factor XII, also known as Hageman factor, is a protein that plays a role in the coagulation cascade, which is the series of events that leads to the formation of a blood clot. It is one of the zymogens, or inactive precursor proteins, that becomes activated and helps to trigger the coagulation process.

When Factor XII comes into contact with negatively charged surfaces, such as damaged endothelial cells or artificial surfaces like those found on medical devices, it undergoes a conformational change and becomes activated. Activated Factor XII then activates other proteins in the coagulation cascade, including Factor XI, which ultimately leads to the formation of a fibrin clot.

Deficiencies in Factor XII are generally not associated with bleeding disorders, as the coagulation cascade can still proceed through other pathways. However, excessive activation of Factor XII has been implicated in certain thrombotic disorders, such as deep vein thrombosis and disseminated intravascular coagulation (DIC).

Collagen Type I is the most abundant form of collagen in the human body, found in various connective tissues such as tendons, ligaments, skin, and bones. It is a structural protein that provides strength and integrity to these tissues. Collagen Type I is composed of three alpha chains, two alpha-1(I) chains, and one alpha-2(I) chain, arranged in a triple helix structure. This type of collagen is often used in medical research and clinical applications, such as tissue engineering and regenerative medicine, due to its excellent mechanical properties and biocompatibility.

Developmental bone diseases are a group of medical conditions that affect the growth and development of bones. These diseases are present at birth or develop during childhood and adolescence, when bones are growing rapidly. They can result from genetic mutations, hormonal imbalances, or environmental factors such as poor nutrition.

Some examples of developmental bone diseases include:

1. Osteogenesis imperfecta (OI): Also known as brittle bone disease, OI is a genetic disorder that affects the body's production of collagen, a protein necessary for healthy bones. People with OI have fragile bones that break easily and may also experience other symptoms such as blue sclerae (whites of the eyes), hearing loss, and joint laxity.
2. Achondroplasia: This is the most common form of dwarfism, caused by a genetic mutation that affects bone growth. People with achondroplasia have short limbs and a large head relative to their body size.
3. Rickets: A condition caused by vitamin D deficiency or an inability to absorb or use vitamin D properly. This leads to weak, soft bones that can bow or bend easily, particularly in children.
4. Fibrous dysplasia: A rare bone disorder where normal bone is replaced with fibrous tissue, leading to weakened bones and deformities.
5. Scoliosis: An abnormal curvature of the spine that can develop during childhood or adolescence. While not strictly a developmental bone disease, scoliosis can be caused by various underlying conditions such as cerebral palsy, muscular dystrophy, or spina bifida.

Treatment for developmental bone diseases varies depending on the specific condition and its severity. Treatment may include medication, physical therapy, bracing, or surgery to correct deformities and improve function. Regular follow-up with a healthcare provider is essential to monitor growth, manage symptoms, and prevent complications.

Dwarfism is a medical condition that is characterized by short stature, typically with an adult height of 4 feet 10 inches (147 centimeters) or less. It is caused by a variety of genetic and medical conditions that affect bone growth, including skeletal dysplasias, hormonal deficiencies, and chromosomal abnormalities.

Skeletal dysplasias are the most common cause of dwarfism and are characterized by abnormalities in the development and growth of bones and cartilage. Achondroplasia is the most common form of skeletal dysplasia, accounting for about 70% of all cases of dwarfism. It is caused by a mutation in the fibroblast growth factor receptor 3 (FGFR3) gene and results in short limbs, a large head, and a prominent forehead.

Hormonal deficiencies, such as growth hormone deficiency or hypothyroidism, can also cause dwarfism if they are not diagnosed and treated early. Chromosomal abnormalities, such as Turner syndrome (monosomy X) or Down syndrome (trisomy 21), can also result in short stature and other features of dwarfism.

It is important to note that people with dwarfism are not "dwarves" - the term "dwarf" is a medical and sociological term used to describe individuals with this condition, while "dwarves" is a term often used in fantasy literature and media to refer to mythical beings. The use of the term "dwarf" can be considered disrespectful or offensive to some people with dwarfism, so it is important to use respectful language when referring to individuals with this condition.

Osteochondrodysplasias are a group of genetic disorders that affect the development of bones and cartilage. These conditions can result in dwarfism or short stature, as well as other skeletal abnormalities. Osteochondrodysplasias can be caused by mutations in genes that regulate bone and cartilage growth, and they are often characterized by abnormalities in the shape, size, and/or structure of the bones and cartilage.

There are many different types of osteochondrodysplasias, each with its own specific symptoms and patterns of inheritance. Some common examples include achondroplasia, thanatophoric dysplasia, and spondyloepiphyseal dysplasia. These conditions can vary in severity, and some may be associated with other health problems, such as respiratory difficulties or neurological issues.

Treatment for osteochondrodysplasias typically focuses on managing the symptoms and addressing any related health concerns. This may involve physical therapy, bracing or surgery to correct skeletal abnormalities, and treatment for any associated medical conditions. In some cases, genetic counseling may also be recommended for individuals with osteochondrodysplasias and their families.

Musculoskeletal abnormalities refer to structural and functional disorders that affect the musculoskeletal system, which includes the bones, muscles, cartilages, tendons, ligaments, joints, and other related tissues. These abnormalities can result from genetic factors, trauma, overuse, degenerative processes, infections, or tumors. They may cause pain, stiffness, limited mobility, deformity, weakness, and susceptibility to injuries. Examples of musculoskeletal abnormalities include osteoarthritis, rheumatoid arthritis, scoliosis, kyphosis, lordosis, fractures, dislocations, tendinitis, bursitis, myopathies, and various congenital conditions.

Achondroplasia is a genetic disorder that affects bone growth, leading to dwarfism. It is the most common form of short-limbed dwarfism and is caused by a mutation in the FGFR3 gene. This mutation results in impaired endochondral ossification, which is the process by which cartilage is converted into bone.

People with achondroplasia have a characteristic appearance, including:

* Short stature (typically less than 4 feet, 4 inches tall)
* Disproportionately short arms and legs
* Large head with a prominent forehead and flat nasal bridge
* Short fingers with a gap between the middle and ring fingers (known as a trident hand)
* Bowing of the lower legs
* A swayed back (lordosis)

Achondroplasia is usually inherited in an autosomal dominant manner, which means that a child has a 50% chance of inheriting the disorder if one parent has it. However, about 80% of cases result from new mutations in the FGFR3 gene and occur in people with no family history of the condition.

While achondroplasia can cause various medical issues, such as breathing difficulties, ear infections, and spinal cord compression, most individuals with this condition have normal intelligence and a typical lifespan. Treatment typically focuses on managing specific symptoms and addressing any related complications.

Thnanatophoric Dysplasia is a severe skeletal disorder characterized by extreme short limbs, a narrow chest, and large head. It is one of the most common types of short-limbed dwarfism. The name "thanatophoric" comes from the Greek word thanatos, meaning death, as this condition is often lethal in the newborn period or shortly thereafter due to respiratory distress.

The disorder is caused by mutations in the FGFR3 gene, which provides instructions for making a protein that is part of a group of proteins called fibroblast growth factor receptors. These receptors play critical roles in many important processes during embryonic development, such as controlling bone growth.

There are two major types of thanatophoric dysplasia: type I and type II. Type I is characterized by curved thigh bones (femurs) and a clover-leaf shaped skull. Type II is characterized by straight femurs and an unossified (not fully developed) vertebral column.

The diagnosis of thanatophoric dysplasia can be made prenatally through ultrasound examination or postnatally through physical examination, X-rays, and genetic testing. Unfortunately, due to the severity of the condition, there is no cure for thanatophoric dysplasia and management is supportive in nature, focusing on providing comfort and addressing any complications that may arise.

Growth disorders are medical conditions that affect a person's growth and development, leading to shorter or taller stature than expected for their age, sex, and ethnic group. These disorders can be caused by various factors, including genetic abnormalities, hormonal imbalances, chronic illnesses, malnutrition, and psychosocial issues.

There are two main types of growth disorders:

1. Short stature: This refers to a height that is significantly below average for a person's age, sex, and ethnic group. Short stature can be caused by various factors, including genetic conditions such as Turner syndrome or dwarfism, hormonal deficiencies, chronic illnesses, malnutrition, and psychosocial issues.
2. Tall stature: This refers to a height that is significantly above average for a person's age, sex, and ethnic group. Tall stature can be caused by various factors, including genetic conditions such as Marfan syndrome or Klinefelter syndrome, hormonal imbalances, and certain medical conditions like acromegaly.

Growth disorders can have significant impacts on a person's physical, emotional, and social well-being. Therefore, it is essential to diagnose and manage these conditions early to optimize growth and development and improve overall quality of life. Treatment options for growth disorders may include medication, nutrition therapy, surgery, or a combination of these approaches.

"Entrez Gene: COL12A1 collagen, type XII, alpha 1". "Collagen, Type XII, Alpha-1; COL12A1 Gene-Phenotype Relationships". Online ... collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to ... This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted ... April 1997). "Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen ( ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... Collagen, type I, alpha 1 (COL1A1) Collagen, type II, alpha 1 (COL2A1) Collagen, type III, alpha 1 (COL3A1) Collagen, type V, ... collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of VWA-containing proteins are ... "Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins". ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... collagen types VI, VII, XII and XIV; and other extracellular proteins. Although the majority of vWA-containing proteins are ... Colombatti A, Bonaldo P, Doliana R (1993). "Type A modules: interacting domains found in several non-fibrillar collagens and in ... This type A domain is the prototype for a protein superfamily (InterPro: IPR036465; see also Pfam clan). The vWA domain is ...
FACIT collagens include collagen types IX, XII, XIV, XIX, and XXI. Triple helix Collagen helix GO term: FACIT collagen[ ... There are eight known types of FACIT collagens: collagens IX, XII, XIV, XVI, XIX, XXI, and XXII. The general FACIT collagen ... FACIT collagen (Fibril Associated Collagens with Interrupted Triple helices) is a type of collagen and also a proteoglycan that ... Other collagen types such as Collagen XX, which are smaller in size are mostly expressed in the connective tissue such as ...
... contains type I collagen and type XII collagen. Michael H. Ross. Histology: A Text and Atlas, with Correlated ... Perichondrium is a type of irregular collagenous ordinary connective tissue, and also functions in the growth and repair of ... Biosynthesis and Gene Regulation of Collagens in Cartilage and Bone", Dynamics of Bone and Cartilage Metabolism (Second Edition ... 3-40, doi:10.1016/b978-012088562-6/50002-9, ISBN 978-0-12-088562-6, retrieved 2020-11-18 Iowa Histology Index 4/iv-05 - "Slide ...
Found to have type I, III, VI, and XII collagen. Connective tissue in skeletal muscle Endomysium Epimysium E. Passerieux, R. ... The overall comprehensive organization of the perimysium collagen network, as well as its continuity and disparateness, however ...
... type III collagen is also an important regulator of the diameter of type I and II collagen fibrils. Type III collagen is also ... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... Type III collagen could also be important in several other human diseases. Increased amounts of type III collagen are found in ... Type III collagen is one of the fibrillar collagens whose proteins have a long, inflexible, triple-helical domain. Type III ...
... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ... "Entrez Gene: COL5A3 collagen, type V, alpha 3". van der Rest M, Garrone R (1991). "Collagen family of proteins". FASEB J. 5 (13 ...
It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of the type IV collagen and plays a role in ... collagen". FEBS Letters. 225 (1-2): 188-94. doi:10.1016/0014-5793(87)81155-9. PMID 3691802. "Entrez Gene: COL4A1 collagen, type ... Type IV collagen is the major structural component of basement membranes, which contains two or three COL4A1 proteins. Thus, ... COL4A1 belongs to the type IV collagen family and contains three domains: a short N-terminal domain, a long triple-helical 7S ...
Type XI collagen also helps maintain the spacing and diameter of type II collagen fibrils. Type II collagen is an important ... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... Instead, another type of collagen chain replaces pro-alpha2(XI) to form type XI collagen in the vitreous of the eye. COL11A2 ... The COL11A2 gene produces one component of this type of collagen, called the pro-alpha2(XI) chain. Type XI collagen adds ...
2005). "Collagen types XII and XIV are present in basement membrane zones during human embryonic development". J. Mol. Histol. ... "Entrez Gene: COL14A1 collagen, type XIV, alpha 1 (undulin)". "COL14A1 - Collagen alpha-1(XIV) chain precursor - Homo sapiens ( ... Tono-Oka S, Tanase S, Miike T, Tanaka H (1996). "Transient expression of collagen type XIV during muscle development and its ... Collagen alpha-1(XIV) chain is a protein that in humans is encoded by the COL14A1 gene. It likely plays a role in collagen ...
"Czech dysplasia metatarsal type: another type II collagen disorder". European Journal of Human Genetics. 15 (12): 1269-1275. ... Czech dysplasia metatarsal type is a rare type of Czech dysplasia which is characterized primarily by bone anomalies. ... "Czech dysplasia metatarsal type - About the Disease - Genetic and Rare Diseases Information Center". rarediseases.info.nih.gov ... "Orphanet: Czech dysplasia metatarsal type". www.orpha.net (in Spanish). Retrieved 2022-07-07. Marik, Ivo; Marikova, Olga; ...
Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, a collagen component of hyaline cartilage. ... "Entrez Gene: COL9A1 collagen, type IX, alpha 1". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...
Type XV collagen is known to be a tumor suppressor that can be used to understand tumor cells environment. Type XV collagen ... This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with ... "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed ... Hägg PM, Hägg PO, Peltonen S, Autio-Harmainen H, Pihlajaniemi T (June 1997). "Location of type XV collagen in human tissues and ...
... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. ... the structure of type I collagen is compromised. Tissues that are rich in type I collagen, such as the skin, bones, and tendons ... Ehlers-Danlos type IV is most attributed to abnormalities in the reticular fibers (collagen Type III). Ehlers-Danlos syndrome, ...
This protein is an alpha chain of type VI collagen that aids in microfibril formation. As part of type VI collagen, this ... This gene encodes the alpha 3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in ... "The 1.6 A structure of Kunitz-type domain from the alpha 3 chain of human type VI collagen". Journal of Molecular Biology. 246 ... "Anisotropic behaviour of the C-terminal Kunitz-type domain of the alpha3 chain of human type VI collagen at atomic resolution ( ...
... chain of type II collagen. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and ... "A COL2A1 mutation in achondrogenesis type II results in the replacement of type II collagen by type I and III collagens in ... type 2 by affecting tissues that are rich in type II collagen. Platyspondylic lethal skeletal dysplasia, Torrance type:Fewer ... chain that cannot be incorporated into type II collagen fibers. As a result, cells make a reduced amount of type II collagen. ...
XII) collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". ... This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with ... other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve ... "Entrez Gene: COL19A1 collagen, type XIX, alpha 1". Yoshioka H, Zhang H, Ramirez F, et al. (1992). "Synteny between the loci for ...
... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... "Entrez Gene: COL5A2 collagen, type V, alpha 2". Mann K (1992). "Isolation of the alpha 3-chain of human type V collagen and ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ...
... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... "Entrez Gene: COL5A1 collagen, type V, alpha 1". Mann K (1992). "Isolation of the alpha 3-chain of human type V collagen and ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ...
"Entrez Gene: COL8A2 collagen, type VIII, alpha 2". Shuttleworth CA (1998). "Type VIII collagen". Int. J. Biochem. Cell Biol. 29 ... Illidge C, Kielty C, Shuttleworth A (1998). "The alpha1(VIII) and alpha2(VIII) chains of type VIII collagen can form stable ... 1991). "The alpha 2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome 1". ... the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy". Hum Mol Genet. 10 ...
Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. ... "Entrez Gene: COL9A2 collagen, type IX, alpha 2". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...
Fibril Associated Collagens with Interrupted Triple Helices) (Type IX, XII, XIV, XIX, XXI) Short chain (Type VIII, X) Basement ... of the collagen in the human body is type I collagen. However, as of 2011, 28 types of human collagen have been identified, ... Type XIII, XVII) Microfibril forming (Type VI) Anchoring fibrils (Type VII) The five most common types are: Type I: skin, ... With type I collagen and possibly all fibrillar collagens, if not all collagens, each triple-helix associates into a right- ...
Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. ... "Entrez Gene: COL9A3 collagen, type IX, alpha 3". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...
... or collagen IV NC1 domain) is a duplicated domain present at the C-terminus of type IV collagens. Each type IV collagen ... Structural basis for type IV collagen assembly in basement membranes". J. Biol. Chem. 277 (34): 31142-53. doi:10.1074/jbc. ... In molecular biology, the type IV collagen C4 domain ( ... The collagen IV C4 domain is composed of two similarly folded ... domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link". Proc. Natl. Acad. ...
UCMD1 is associated with variants of type VI collagen, while UCMD2 is associated with variants of type XII collagen. UCMD is ... "COL6A1 collagen type VI alpha 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-05-11. Bushby KM, ... Alpha 1 subunit of type VI collagen is the encoded protein. In terms of the genetics of UCMD2, there are mutations in the gene ... Collagen type VI myopathies. Adv Exp Med Biol 802:185-199 Reed, Umbertina Conti; Ferreira, Lucio Gobbo; Liu, Enna Cristina; ...
Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions". J. ... Von Willebrand factor type D domain (vWD) is an evolutionarily-conserved protein domain found in, among others, the von ... "The secondary structure of the von Willebrand factor type A domain in factor B of human complement by Fourier transform ... Willebrand factor (vWF). vWF is a large multimeric glycoprotein and it is synthesized by a type of bone marrow cell called ...
Collagen, type I, alpha 1 Collagen, type II, alpha 1 Collagen, type III, alpha 1 Collagen, type IV, alpha 1 Collagen, type V, ... type VI, alpha 1 Collagen, type VII, alpha 1 Collagen, type VIII, alpha 1 Collagen, type IX, alpha 1 Collagen, type X, alpha 1 ... collagen (type I, II, VI, X collagen fibrils) and proteoglycans. The ratio and the proportion of collagen play an important ... "Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen". Cell and ...
... is caused by a mutation on the COL12A1 gene coding for type XII collagen. It is autosomal dominant. Gowers's sign, toe walking ... There are two types of Bethlem myopathy, based on which type of collagen is affected. Bethlem myopathy 1 (BTHLM1), formerly ... is caused by a mutation in one of the three genes coding for type VI collagen. These include COL6A1, COL6A2, and COL6A3. It is ... Bethlem myopathy 2 (BTHLM2), formerly known as myopathic-type Ehlers-Danlos syndrome, ...
Ullrich congenital muscular dystrophy and Bethlem myopathy - defects in collagen (type VI and XII), results in progressive ... Psoriatic arthritis is also a collagen vascular disease. Peyronie's disease - involving the growth of abnormal collagen (Type I ... Type I or III) and cause progressive deterioration of collagen, with different EDS types affecting different sites in the body ... Diseases in which inflammation or weakness of collagen tends to occur are also referred to as collagen diseases. Collagen ...
"Entrez Gene: COL12A1 collagen, type XII, alpha 1". "Collagen, Type XII, Alpha-1; COL12A1 Gene-Phenotype Relationships". Online ... collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to ... This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted ... April 1997). "Complete primary structure of two splice variants of collagen XII, and assignment of alpha 1(XII) collagen ( ...
Molecular mechanisms for OI types I-IV are mutations in type 1 collagen genes COLA1 and COLA2. Types V-XII are rarer forms. ... Mutations in type II collagen cause a large number of disorders classified as spondyloepiphyseal dysplasia (ie, ... Infant with Beemer-type (left) and an infant with Majewski-type (right) short-rib syndrome (SRS). Note severe micrognathia/ ... Infant with Beemer-type (left) and an infant with Majewski-type (right) short-rib syndrome (SRS). Note severe micrognathia/ ...
Different Types of Rugs. * Collagen in Medical Procedures. Advertisement. Follow me on Twitter. Tweets by @BakesPlace ...
Immunohistochemical staining for type II collagen. Collagen type II staining was positive in group I (A), but was absent in ... Immunohistochemical staining for type II collagen. Collagen type II staining was positive in group I (A), but was absent in ... Type-II collagen was immunolocalized with a mouse antibody to mouse anti-human type-II collagen (1:100; Daiichi Fine Chemical ... FIGURE 5 - Immunohistochemical staining for type II collagen. Collagen type II staining was positive in group I (A), but was ...
19, 20, 21] These result in abnormal type II collagen. Type II collagen is the major collagen of nucleus pulposus (spine), ... Type II collagen is a primary matrix protein of physeal and epiphyseal cartilage. Because an abnormality in type II collagen ... With the increasing molecular definition of several types of collagen and recognition of the concentration of certain types in ... SED Maroteaux type is a form with manifestations limited to the musculoskeletal system. [7] SED tarda Toledo type is a form of ...
Fibrosis, characterized by increased immunoexpression of collagen type I by 8 weeks and connective tissue growth factor by 12 ... The conduction velocity (NCV) within the carpal tunnel showed a modest but significant decline after 9-12 weeks. The lowest NCV ...
... meaning a persons body can convert them into collagen. Collagen supplements can help. retain moisture, and vitamins to help ... Protein type and ingredients. It is best to check the products label before committing to a purchase. The label should include ... Best for older women: Sunwarrior Collagen Building Protein Peptides. This protein powder is vegan and free from soy, gluten, ... Animal-based protein powders often contain casein, whey, collagen, and eggs. Plant-based products often contain pea, rice, and ...
MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen. Biochemistry. ... 2006 Mar 28;45(12):3863-74. doi: 10.1021/bi052252o. Citation on PubMed or Free article on PubMed Central ...
ITEM DESCRIPTION & CODES OR NOTES 101- What is the main type of heating system 102 you have? 11 - Steam or hot water system 12 ... Collagen disease Scleredema 36 Alcoholism 38 Whiplash This page last reviewed: Thursday, January 28, 2016 This information is ... Table 17 Weighted Average Thresholds-Poverty Cutoffs in 1979, By size and Type of Family, By Farm-Nonfarm Residence NONFARM ... Table 17 Weighted Average Thresholds-Poverty Cutoffs In 1980, By Size and Type of Family, By Farm-Nonfarm Residence NONFARM ...
... type IV), dimethyl sulfoxide (DMSO), and dexamethasone were purchased from Sigma (St. Quentin Fallavier, France). Collagen- ... precoated with collagen at 10 × 106 cells/plate in a total volume of 6 ml of a hormonally and chemically defined medium ... After 12 to 16 h, the medium was changed, and fresh medium containing 0.1% DMSO or inducers was added. Cells were harvested in ... 1998) SXR, a novel steroid and xenobiotic-sensing nuclear receptor. Genes Dev 12:3195-3205. ...
Activation of immune responses against the basement membrane component collagen type IV does not affect the development of ... Use of Vascular Assessments and Novel Biomarkers to Predict Cardiovascular Events in Type 2 Diabetes: The SUMMIT VIP Study. ... Elevated circulating effector memory T cells but similar levels of regulatory T cells in patients with type 2 diabetes mellitus ... Vallejo, J., Dunér, P., To, F., Engelbertsen, D., Gonçalves, I., Nilsson, J. & Bengtsson, E., 2019 Apr 12, In: Scientific ...
Expression of collagen type 1 in the normal eye was observed in the cornea and sclera, but not in the conjunctiva (Fig. 4A). By ... Twelve- to 14-week-old Japanese white rabbits (KBT Oriental, Saga, Japan) were used for the animal experiments. All experiments ... Immunohistochemical analyses of collagen type 1. Normal (A) and operated eyes (trabeculectomy; B, D, MicroShunt insertion; C, E ... Immunohistochemical analyses of collagen type 1. Normal (A) and operated eyes (trabeculectomy; B, D, MicroShunt insertion; C, E ...
Fibrillar collagens of types I, […]. What are Collagen Wound Dressings?. Collagen wound dressings are sheets, pads, plugs, gels ... The majority of collagen types are members of the fibril-forming or fibrillar subfamily. This group includes collagen types I ... What Type of Collagen is Best for Wound Healing?. There are 28 different kinds of collagen, which are further subdivided into ... Collagen Formats Make a Difference. In general, the formats of collagen wound dressing like the collagen sheet, sponge, film ...
... type IVa and classified as sequence type 8 (ST8) by multilocus sequence typing (4,5). ... homogeneous collagen bundles (sclerosing dermatitis). This pattern of inflammation is distinct from most staphylococcal ... Typing was performed by SmaI pulsed-field gel electrophoresis as previously described (2), and the isolate was classified as ... Volume 12, Number 12-December 2006 Letter. Methicillin-resistant Staphylococcus aureus in Cat and Owner On This Page ...
Collagen Type XII. *Collateral Circulation. *Colony Count, Microbial. *Combinatorial Chemistry Techniques. *Combined Modality ...
Compared with the carp fish ordinary muscle type I collagen, porcine dermis type I collagen and other seawater fish collagens, ... Keywords: Carp Fish Scale, ASC (Acid-Solubilized Collagens), PSC (Pepsin-Solubilized Collagens), Type I Collagen ... These collagens are mainly type I collagen with a lower denaturation temperatures than the collagen of porcine dermis. These ... Fish scales are biocomposites of highly ordered type I collagen fibers and hydroxyapatite Ca10(OH)2(PO4)6 [1-3]. Collagens ...
Collagen Production. One of the key benefits of red light therapy is its ability to stimulate collagen production. Collagen is ... Additionally, use a moisturizer suited to your skin type to lock in hydration and keep your skin soft and supple. ... As we age, collagen production declines, leading to the formation of fine lines. By boosting collagen levels, red light therapy ... Prolonged sun exposure can break down collagen and elastin fibers in dark skin, leading to the early appearance of fine lines. ...
... contributing to collagen fibrogenesis. On the other hand, type XII collagen increased at the PDL-cementum boundary of the ... We revealed the presence of type II collagen in PDL, possibly associated with the load-bearing function upon occlusal force. ... Notably, the proportion of type VI collagen significantly increased at the mesial side, ... METHODS: Two types of combined lightings were compared; one consisted of a high-CCT (12000 K) light-emitting diode (LED) panel ...
This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a ... collagen alpha-1(XI) chain. Names. collagen XI, alpha-1 polypeptide. collagen, type XI, alpha 1. deafness, autosomal dominant ... COL11A1 collagen type XI alpha 1 chain [Homo sapiens] COL11A1 collagen type XI alpha 1 chain [Homo sapiens]. Gene ID:1301 ... collagen type XI alpha 1 chainprovided by HGNC. Primary source. HGNC:HGNC:2186 See related. Ensembl:ENSG00000060718 MIM:120280; ...
When you exercise, your body produces more collagen, elastin, and other proteins that support healthy skin. Stretching helps ... Types of Stretches. There are two types of stretching: static and dynamic. Static stretching involves holding a position for a ... Both types of stretching are beneficial, but there are some differences.. 1. Static Stretching. Static stretching is typically ... 29 Benefits of Stretching ( With Types). By Rohit SharmaPosted on July 4, 2022. March 3, 2023. ...
DTaP, IPV, HBV and Hib*: (Diphtheria, tetanus, pertussis; polio; hepatitis B and Haemophilus influenza type B) Given to infants ... Gelatin: Derived from the collagen inside animals skin and bones. Injecting gelatin poses the risk of infection from synthetic ... 2 to 12 months with boosters less than a year later. Contains aluminum hydroxide, formaldehyde and bovine cow serum. Gardasil ...
Type 1 collagenopathy presenting with a Russell-Silver phenotype. Parker MJ, Deshpande C, Rankin J, Wilson LC, Balasubramanian ... Defect in proline synthesis: pyrroline-5-carboxylate reductase 1 deficiency leads to a complex clinical phenotype with collagen ... Epub 2013 Mar 12. Am J Med Genet A. 2013. PMID: 23494979 ... Epub 2011 May 12. Am J Med Genet A. 2011. PMID: 21567925 ...
":"Collagen","type":"Skincare\/Beauty","tags":["Adashiko Collagen","Face"],"price":9999,"price_min":9999,"price_max":9999," ... Step 2 A collagen + Noni gel that when applied to the skin will further boost collagen growth. It will also work on the ... It also carries the collagen into the deeper skin tissue where the Collagen regenerates and rebuilds the skin skin structure.\ ... It also carries the collagen into the deeper skin tissue where the Collagen regenerates and rebuilds the skin skin structure.\ ...
This is a peel-off type lip tint that leaves a vibrant color on your lips for over twelve hours. Just paint, dry, and peel! It ... Hydrolyzed Collagen, CI 45410:1 Allantoin, Dipotassium Glycyrrhaate, Sodium Hyaluronate ... Hydrolyzed Collagen, CI 45410:1 Allantoin, Dipotassium Glycyrrhaate, Sodium Hyaluronate ... Hydrolyzed Collagen, CI 45410:1 Allantoin, Dipotassium Glycyrrhaate, Sodium Hyaluronate ...
Collagen type IV alpha 2 (COL4A2, MIM 120090), is the major structural component of basement membranes. The C-terminal portion ... Collagen type IV alpha 2 (COL4A2), a major component of the basement membrane, dynamically influences a wide range of ... Bunt S, Hooley C, Hu N, Scahill C, Weavers H, Skaer H. Hemocyte-secreted type IV collagen enhances BMP signaling to guide renal ... siRNA-mediated suppression of collagen type iv alpha 2 (COL4A2) mRNA inhibits triple-negative breast cancer cell proliferation ...
... and type II collagen C2C were analyzed by immunoassays. Objectively measured PA (steps/day) was collected during 12 weeks from ... and type II collagen C2C were analyzed by immunoassays. Objectively measured PA (steps/day) was collected during 12 weeks from ... type. Contribution to journal publication status. published. subject. *Rheumatology and Autoimmunity. keywords. hip ...
Chocolate Collagen Peanut Butter Smoothie Perfectly Pure Type II Collagen Capsules Perfectly Pure Collagen Perfect Type II ... Perfect Type II Collagen (Cartilage) is now the worlds first 100% bovine cartilage collagen to receive the Glyphosate Residue ... Perfect Type II Collagen is The Worlds First Glyphosate Residue Free Certified Bovine Cartilage. Nov 21st 2019. The Perfect ... Perfectly Pure Collagen Elderberry Perfectly Pure Collagen Chocolate Vitamin C and Collagen ...
Levels of serum 25-hydroxy vitamin D, serum osteocalcin, and total serum collagen type N-terminal extension of the peptide were ... Patients with type 2 diabetes and albuminuria who were receiving angiotensin-converting enzyme inhibitors or angiotensin ... Selective vitamin D receptor activation with paricalcitol for reduction of albuminuria in patients with type 2 diabetes (VITAL ... Differing mechanisms may be involved in different tumor types and under different experimental conditions. Pre-clinical data ...
  • This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted triple helices) collagen family. (wikipedia.org)
  • This group includes collagen types I and III, which make up the majority of the extracellular matrix in the dermal layer of skin. (iwound.com)
  • Collagen alpha-1(XII) chain is a protein that in humans is encoded by the COL12A1 gene. (wikipedia.org)
  • These types encompass the full spectrum of OI severity, from perinatal lethal type II to progressively deforming type III to mild and diagnostically delayed type I. The rare forms of OI (types V-XVIII) delineated in the last decade have (except for type V and some XV) autosomal recessive inheritance and are caused by mutations in genes whose protein products interact with collagen for post-translational modification or folding. (nih.gov)
  • Type II collagen is a primary matrix protein of physeal and epiphyseal cartilage. (medscape.com)
  • Animal-based protein powders often contain casein, whey , collagen , and eggs . (medicalnewstoday.com)
  • C-type lectin (CTL) is a Ca 2+ -dependent glycan-binding protein (GBP) that shares primary and secondary structural homology in its carbohydrate-recognition domain (CRD). (biomedcentral.com)
  • Collagen is a protein produced naturally in the human body that aids in wound healing and tissue regeneration. (iwound.com)
  • Collagen is a crucial protein that is vital to the human body. (zazu.net)
  • Collagen is an important protein in the organisms, and the use of collagen in industry for health foods, cosmetics, and biomaterials is expanding. (scirp.org)
  • Collagen is a structural protein found abundantly in our bodies. (yogicosmetics.com)
  • Protein known as "structural", collagen make up the organism by giving it structure. (lapara.ca)
  • Serum concentrations of the inflammatory marker C-reactive protein (CRP) and the cartilage markers Alanine-Arginine-Glycine-Serine (ARGS)-aggrecan, cartilage oligomeric matrix protein (COMP), and type II collagen C2C were analyzed by immunoassays. (lu.se)
  • This advanced formula contains a unique blend of hydrolyzed collagen peptides, vitamins, and minerals essential for hair health. (yogicosmetics.com)
  • Incorporate anti-aging serums or treatments containing ingredients like retinol, vitamin C, or peptides, which can stimulate collagen production and thereby reduce wrinkles and the appearance of fine lines. (kozehealth.com)
  • With the increasing molecular definition of several types of collagen and recognition of the concentration of certain types in cartilage tissue, many skeletal dysplasias came to be defined as collagen abnormalities. (medscape.com)
  • With the increasing molecular definition of several types of collagen and recognition of the concentration of certain types in cartilage tissue, many skeletal dysplasias have now been defined as collagen abnormalities. (medscape.com)
  • There are more then 12 types of collagen but the one that is present in cartilage is type-II collagen. (lapara.ca)
  • With rheumatoid arthritis, complex immune mechanisms destroy type-II collagen in the cartilage. (lapara.ca)
  • Presence of factor V Leiden mutation raises the possibility that the infarct was due to acute coronary thrombosis, although coronary artery aneurysm and dissection with myocardial infarction is known to occur in vascular type EDS. (wjgnet.com)
  • Collagens are the most abundant proteins, the collagen family comprises 28 members (I-XXVIII) [5, 6]. (researchsquare.com)
  • As we age, our skin naturally loses collagen and elastin, the proteins responsible for keeping it firm and elastic. (kozehealth.com)
  • Studies in knockout mice have shown that lack of type IX collagen is associated with early onset osteoarthritis. (researchsquare.com)
  • In this study, we conducted scRNA-seq analysis of submandibular gland tissues from patients with IgG4-RD. Our findings unveil the presence of a disease-related cell subset, namely collagen type XV-expressing fibroblasts, which may have distinct functions. (biomedcentral.com)
  • 1% sodium bicarbonate (NaHCO ) dis- ions in tissues such as collagen or muscle. (who.int)
  • A stem cell is commonly defined as a cell that has the ability to continuously divide and produce progeny cells that differentiate (develop) into various other types of cells or tissues. (bvsalud.org)
  • Studies reported that Type XIX collagen may contribute to brain disorders [15], but no data on the relationship between COL19A1 polymorphisms and KBD risk. (researchsquare.com)
  • U Collagen offers a solution by replenishing the lost collagen, strengthening the hair shaft, and improving hair elasticity. (yogicosmetics.com)
  • These delicate creases and wrinkles are the first signs of aging skin, resulting from a combination of factors such as decreased collagen production, reduced skin elasticity, and repetitive facial expressions. (kozehealth.com)
  • This reduction in the retin a collagen breakdown in skin elasticity leads to the formation of fine lines, particularly in areas where the skin is thinner and more delicate, such as around the eyes and mouth. (kozehealth.com)
  • Fish scales are biocomposites of highly ordered type I collagen fibers and hydroxyapatite Ca 10 (OH) 2 (PO 4 ) 6 [1-3]. (scirp.org)
  • One of the three alpha chains of type IX collagen are coded by COL9A1 gene, which is essential for the functional longevity of joint cartilages and connected with osteochondropathy [7, 8]. (researchsquare.com)
  • Specially, it is reported that COL9A1 rs6910140 was significantly associated with KBD risk in a northwest Chinese Han population [12]. (researchsquare.com)
  • Furthermore, immune-suppressive therapy in active IgG4-RD patients resulted in decreased serum levels of collagen type XV. (biomedcentral.com)
  • Furthermore, we demonstrate that serum levels of collagen type XV could serve as a monitoring tool for IgG4-RD patients. (biomedcentral.com)
  • Healthy volunteers were recruited as controls for serum collagen type XV assessment. (biomedcentral.com)
  • A sandwich ELISA for quantitative measurement of Rat Collagen Type II Antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (gentaur.pl)
  • Anti-RANK ligand antibody improves bone mineral density in individuals with OI types I, III, IV and VI without accumulating in the bone matrix. (nih.gov)
  • E02C2519-48 Rat Collagen Type II Antibody ELIS. (gentaur.pl)
  • Prolonged sun exposure can break down collagen and elastin fibers in dark skin, leading to the early appearance of fine lines. (kozehealth.com)
  • Fibrosis, characterized by increased immunoexpression of collagen type I by 8 weeks and connective tissue growth factor by 12 weeks, was evident. (cdc.gov)
  • Ehlers-Danlos syndrome (EDS) is a group of inherited connective tissue disorders caused by collagen synthesis defects. (wjgnet.com)
  • Based on their origin, there are two main types of stem cells - embryonic stem cells (ES cells) and postnatal or adult stem cells (AS cells). (bvsalud.org)
  • Compared with the carp fish ordinary muscle type I collagen, porcine dermis type I collagen and other seawater fish collagens, freshwater carp fish scales collagen contained relative high half-cystine (Cys-s), but lower denaturation temperature(Td) than the porcine dermis type I collagen. (scirp.org)
  • At present, because of the outbreak of bovine spongiform encephalopathy (BSE) and the foot-and-mouth disease (FMD), the main sources of collagen in many fields are limited to those of bovine or porcine dermis, so more and more studies turn to find safe sources of collagen. (scirp.org)
  • These collagens are mainly type I collagen with a lower denaturation temperatures than the collagen of porcine dermis. (scirp.org)
  • The classical Sillence types of OI (types I-IV) with autosomal dominant inheritance comprise about 80-85% of cases and are caused by mutations in the genes that encode type I collagen, COL1A1 and COL1A2 . (nih.gov)
  • Contain some vitamin C: Ascorbic acid contributes to collagen biosynthesis. (lapara.ca)
  • Because an abnormality in type II collagen should affect the molecules throughout the body, it remains unclear how the currently defined abnormality can translate into major structural abnormalities of the vertebrae and capital femoral epiphysis while leaving the distal femur, proximal tibia, and other regions structurally unaffected. (medscape.com)
  • The supernatants were combined and salted out by adding NaCl to a final concentration of 0.7 M. The precipitated collagens were separated by centrifugation at 10,000× g for 30 min and redissolved in 0.5 M acetic acid to precipitate with NaCl again. (scirp.org)
  • Studies have indicated abnormal synthesis of type II collagen in SED congenita. (medscape.com)
  • While collagen is naturally produced by our bodies, the production tends to decline with age, leading to visible signs of aging such as wrinkles, brittle nails, and thinning hair. (yogicosmetics.com)
  • The results of SDS-PAGE showed that purified collagens were composed of at least two different chains which were in accordance with the type I collagen with α chain composition of (α 1 ) 2 α 2 . (scirp.org)
  • [ 7 ] SED tarda Toledo type is a form of SED tarda with peripheral corneal opacities and a qualitative abnormality of urinary mucopolysaccharides, mainly chondroitin-6-sulfate. (medscape.com)
  • However, the low sequence complexity and the presence of short lysine-rich repeats in the regions have hindered the accurate determination of types and locations of PTMs using conventional proteomic procedures. (bvsalud.org)
  • Histopathologic findings demonstrated ulcers and dermal granulation tissue with linearly arranged eosinophils, mast cells, neutrophils, and plasma cells between dense, homogeneous collagen bundles (sclerosing dermatitis). (cdc.gov)
  • To study the effect of tap water `softening' (i.e. calcium extraction) on H&E stains, 5 sets of slides from 30 different paraffin-embedded human pathologic tissue blocks were prepared in the same way except for washing with 5 different types of water. (who.int)
  • These collagens had evident absorption at 230 nm by UV-Vis spectra. (scirp.org)
  • 3. Mix the U Collagen powder with your favorite beverage, such as water, juice, or smoothie. (yogicosmetics.com)
  • Featuring our Tri-level Thickening Complex, this plumping trio of Biotin for volume, Collagen to fortify, and Coffee to help boost strands will enhance the appearance of hair without leaving it feeling heavy. (kislike.com)
  • Ham's F-12 and Williams' E culture media, vitamins and hormones, collagenase (type IV), dimethyl sulfoxide (DMSO), and dexamethasone were purchased from Sigma (St. Quentin Fallavier, France). (aspetjournals.org)
  • The Skeletal Dysplasia Management Consortium has developed best practice guidelines for diagnosis and management of type II collagen skeletal dysplasias (including SED). (medscape.com)
  • Type XIX collagen was involved in the initial stages of skeletal muscle cell differentiation [14]. (researchsquare.com)
  • Note disproportionately short stature with mesomelic shortening and deformities of forearms and legs (in mesomelic dysplasia) and short forearms with Madelung-type deformity (in Leri-Weill syndrome). (medscape.com)
  • The conduction velocity (NCV) within the carpal tunnel showed a modest but significant decline after 9-12 weeks. (cdc.gov)
  • Specimens were harvested at 12 weeks after implantation, examined histologically for morphologic features, and stained immunohistochemically for type-II collagen. (scielo.br)
  • Intraocular pressure (IOP) was measured on conscious rabbits using a rebound tonometer for up to 12 weeks after surgery. (arvojournals.org)
  • In both groups, the IOP of the operative eye was significantly lower than that of the contralateral eye at one day postoperatively, which continued until 12 weeks after surgery. (arvojournals.org)
  • Objectively measured PA (steps/day) was collected during 12 weeks from activity trackers used by 53 participants. (lu.se)
  • By supplementing your body with U Collagen, you can effectively replenish the declining collagen levels and boost hair strength from within. (yogicosmetics.com)
  • however, USA300 has previously been reported to carry staphylococcal cassette chromosome mec (SCCmec) type IVa and classified as sequence type 8 (ST8) by multilocus sequence typing ( 4 , 5 ). (cdc.gov)
  • La concentration sérique pour ces facteurs chez les femmes non encein- tes était similaire à celle des femmes enceintes en bonne santé. (who.int)
  • Toutefois, la concentration sérique était significativement plus élevée en présence d'une prééclampsie bénigne ou grave par rapport aux grossesses normales et significativement plus élevée pour les prééclampsies graves par rapport aux prééclampsies bénignes. (who.int)
  • Males and females often benefit from differing vitamin and mineral types, quantities, and combinations. (medicalnewstoday.com)
  • MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen. (medlineplus.gov)
  • Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to modify the interactions between collagen I fibrils and the surrounding matrix. (wikipedia.org)
  • In this section, we will explore the different types of collagen found in the human body and their significance. (zazu.net)
  • Positive immunohistochemical staining of type-II collagen was observed in group I and it was absent in the control group. (scielo.br)
  • This non-invasive treatment uses low-level wavelengths of red light to penetrate deep into the skin, stimulating collagen production and cellular regeneration. (kozehealth.com)
  • The demineralized scales were washed three times with distilled water for collagen extraction. (scirp.org)
  • Each type of liver cell was isolated from rats and cultured. (jsnm.org)
  • Our findings suggest that collagen type XV-producing fibroblasts may represent a disease-characterizing non-immune cell population in IgG4-RD and hold potential as a disease-monitoring marker. (biomedcentral.com)
  • ES cells are pluripotent cells, which mean that they can give rise to all differentiated cell types derived from all three germ layers. (bvsalud.org)
  • Dwarfing conditions are frequently referred to as short-limb or short-trunk types, according to whether the limbs or the trunk is more extensively involved. (medscape.com)
  • Immunohistochemical analysis confirmed a significant presence of collagen type XV-positive fibroblasts in IgG4-RD patients. (biomedcentral.com)
  • Modern nutritional habits are strongly responsible for generalized collagen deficiency. (lapara.ca)
  • However, due to factors like age, environmental stressors, and poor nutrition, collagen levels in our bodies may deplete, leading to hair-related issues. (yogicosmetics.com)
  • Collagen-coated culture dishes were obtained from Corning (Iwaki, Japan). (aspetjournals.org)
  • This can lead to a decrease in collagen production and result in the early formation of fine lines and facial wrinkles, especially around the mouth. (kozehealth.com)
  • There have been many reports of collagen in aquatic animals. (scirp.org)
  • Additionally, we measured the levels of collagen type XV in the sera of IgG4-RD patients. (biomedcentral.com)
  • Curly and coily hair types often suffer from dryness and lack of definition. (yogicosmetics.com)
  • By using U Collagen regularly, you can enjoy longer-lasting vibrant color while maintaining the health and strength of your locks. (yogicosmetics.com)
  • In conclusion, U Collagen is a game-changer when it comes to enhancing your hair's health and appearance. (yogicosmetics.com)