Collagen type xi. Medical search

A fibrillar collagen found primarily in interstitial CARTILAGE. Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits.

A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).

The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.

Contacts with fibrils containing collagen I, but not collagens II, IX, and XI, can destabilize the cartilage phenotype of chondrocytes. (1/125)

OBJECTIVE: Cell-matrix interactions are important regulators of cellular functions, including matrix synthesis, proliferation and differentiation. This is well exemplified by the characteristically labile phenotype of chondrocytes that is lost in monolayer culture but is stabilized in suspension under appropriate conditions. We were interested in the role of collagen suprastructures in maintaining or destabilizing the cartilage phenotype of chondrocytes. DESIGN: Primary sternal chondrocytes from 17-day-old chick embryos were cultured in gels of fibrils reconstituted from soluble collagen I from various sources. The culture media either contained or lacked FBS. Cells were cultured for up to 28 days and the evolution of the phenotype of the cells was assessed by their collagen expression (collagens II and X for differentiated chondrocytes and hypertrophic chodrocytes, repectively; collagen I for phenotypically modulated cells), or by their secretion of alkaline phosphatase (hypertrophic cartilage phenotype). RESULTS: The cells often retained their differentiated phenotype only if cultured with serum. Under serum-free conditions, cartilage characteristics were lost. The cells acquired a fibroblast-like shape and, later, synthesized collagen I instead of cartilage collagens. Shape changes were influenced by beta1-integrin-activity, whereas other matrix receptors were important for alterations of collagen patterns. Heterotypic fibrils reconstituted from collagens II, IX, and XI did not provoke this phenotypic instability. CONCLUSIONS: Chondrocytes sensitively recognize the suprastructures of collagen fibrils in their environment. Cellular interactions with fibrils with appropriate molecular organizations, such as that in cartilage fibrils, result in the maintenance of the differentiated cartilage phenotype. However, other suprastructures, e.g. in reconstituted fibrils mainly containing collagen I, lead to cell-matrix interactions incompatible with the cartilage phenotype. The maintenance of the differentiated traits of chondrocytes is pivotal for the normal function of, e.g., articular cartilage. If pathologically altered matrix suprastructures lead to a dysregulation of collagen production also in vivo compromised cartilage functions inevitably will be propagated further. (+info)

Articular cartilage repair using a tissue-engineered cartilage-like implant: an animal study. (2/125)

OBJECTIVE: Because articular cartilage has limited ability to repair itself, treatment of (osteo)chondral lesions remains a clinical challenge. We aimed to evaluate how well a tissue-engineered cartilage-like implant, derived from chondrocytes cultured in a novel patented, scaffold-free bioreactor system, would perform in minipig knees with chondral, superficial osteochondral, and full-thickness articular defects. DESIGN: For in vitro implant preparation, we used full-thickness porcine articular cartilage and digested chondrocytes. Bioreactors were seeded with 20x10(6) cells and incubated for 3 weeks. Subsequent to culture, tissue cartilage-like implants were divided for assessment of viability, formaldehyde-fixed and processed by standard histological methods. Some samples were also prepared for electron microscopy (TEM). Proteoglycans and collagens were identified and quantified by SDS-PAGE gels. For in vivo studies in adult minipigs, medial parapatellar arthrotomy was performed unilaterally. Three types of defects were created mechanically in the patellar groove of the femoral condyle. Tissue-engineered cartilage-like implants were placed using press-fit fixation, without supplementary fixation devices. Control defects were not grafted. Animals could bear full weight with an unlimited range of motion. At 4 and 24 weeks postsurgery, explanted knees were assessed using the modified ICRS classification for cartilage repair. RESULTS: After 3-4 weeks of bioreactor incubation, cultured chondrocytes developed a 700-microm- to 1-mm-thick cartilage-like tissue. Cell density was similar to that of fetal cartilage, and cells stained strongly for Alcian blue and safranin O. The percentage of viable cells remained nearly constant (approximately 90%). Collagen content was similar to that of articular cartilage, as shown by SDS-PAGE. At explantation, the gross morphological appearance of grafted defects appeared like normal cartilage, whereas controls showed irregular fibrous tissue covering the defect. Improved histologic appearance was maintained for 6 months postoperatively. Although defects were not always perfectly level upon implantation at explanation the implant level matched native cartilage levels with no tissue hypertrophy. Once in place, implants remodelled to tissues with decreased cell density and a columnar organization. CONCLUSIONS: Repair of cartilage defects with a tissue-engineered implant yielded a consistent gross cartilage repair with a matrix predominantly composed of type II collagen up to 6 months after implantation. This initial result holds promise for the use of this unique bioreactor/tissue-engineered implant in humans. (+info)

COL11A1 in FAP polyps and in sporadic colorectal tumors. (3/125)

BACKGROUND: We previously reported that the alpha-1 chain of type 11 collagen (COL11A1), not normally expressed in the colon, was up-regulated in stromal fibroblasts in most sporadic colorectal carcinomas. Patients with germline mutations in the APC gene show, besides colonic polyposis, symptoms of stromal fibroblast involvement, which could be related to COL11A1 expression. Most colorectal carcinomas are suggested to be a result of an activated Wnt- pathway, most often involving an inactivation of the APC gene or activation of beta-catenin. METHODS: We used normal and polyp tissue samples from one FAP patient and a set of 37 sporadic colorectal carcinomas to find out if the up-regulation of COL11A1 was associated with an active APC/beta-catenin pathway. RESULTS: In this study we found a statistically significant difference in COL11A1 expression between normal tissue and adenomas from one FAP patient, and all adenomas gave evidence for an active APC/beta-catenin pathway. An active Wnt pathway has been suggested to involve stromal expression of WISP-1. We found a strong correlation between WISP-1 and COL11A1 expression in sporadic carcinomas. CONCLUSIONS: Our results suggest that expression of COL11A1 in colorectal tumors could be associated with the APC/beta-catenin pathway in FAP and sporadic colorectal cancer. (+info)

Expression of collagen and aggrecan genes in normal and osteoarthritic murine knee joints. (4/125)

OBJECTIVE: The STR/ort mouse strain develops osteoarthritis (OA) of the medial tibial cartilage whilst CBA mice do not develop this disease. We investigated whether changes occur in the expression of genes encoding major extracellular matrix proteins in the connective tissue of the murine knee joint in OA. DESIGN: Expression of the genes encoding collagens II (Col2alpha1), X (Col10alpha1), alpha2(XI) (Col11alpha2) and aggrecan (Agc) was detected in skeletally mature and immature male mice of the CBA and STR/ort strains by in situ hybridization. RESULTS: Col2alpha1 was expressed by chondrocytes of the tibial and patella-femoral cartilage and by the meniscal cartilage in all young mice (4-9 weeks) but only in the patella-femoral cartilage in older mice of both strains (36-45 weeks). In contrast Col2alpha1 was expressed by growth plate chondrocytes of both species at all ages. Similarly, Col2alpha1 transcripts were detected in cruciate ligament cells in both strains at all ages. Col10alpha1 transcripts were detected in cruciate ligament cells in both strains at all ages. Col10alpha1 expression was evident in the hypertrophic chondrocytes in the growth plate of young CBA and STR mice, but was not active in these cells in mature animals. However, Col10alpha1 was transcribed in articular chondrocytes of the tibia, meniscal and patella-femoral cartilages of all ages, in normal and osteoarthritic mice. Transcripts were also present in ligament of some mature animals. Col11alpha2 followed a similar pattern of expression in CBA cartilages to Col2alpha1, being active in adult growth plate but generally inactive in adult articular cartilages. Young CBA and STR/ort mice expressed Col11alpha2 in articular cartilage and very strongly throughout the growth plate. Agc expression was detected in all articular cartilages at all ages in both strains. Interestingly, transcripts for all four genes were absent in tibial articular chondrocytes located close to osteoarthritic lesions in STR/ort mice, indicating that these cells are unable to synthesize matrix proteins. Adult STR/ort mice also showed evidence of tissue remodeling around the periphery of the knee joint. Cells in remodeling areas actively transcribed Col2alpha1, Col10alpha1, Col11alpha2 and Agc. CONCLUSION: It is unlikely that OA develops in STR/ort mice because of failure to express major proteins in joint tissue. However, once lesions develop in articular cartilage neighbouring chondrocytes fail to express genes encoding several matrix proteins. (+info)

A Kruppel-associated box-zinc finger protein, NT2, represses cell-type-specific promoter activity of the alpha 2(XI) collagen gene. (5/125)

Type XI collagen is composed of three chains, alpha 1(XI), alpha 2(XI), and alpha 3(XI), and plays a critical role in the formation of cartilage collagen fibrils and in skeletal morphogenesis. It was previously reported that the -530-bp promoter segment of the alpha 2(XI) collagen gene (Col11a2) was sufficient for cartilage-specific expression and that a 24-bp sequence from this segment was able to switch promoter activity from neural tissues to cartilage in transgenic mice when this sequence was placed in the heterologous neurofilament light gene (NFL) promoter. To identify a protein factor that bound to the 24-bp sequence of the Col11a2 promoter, we screened a mouse limb bud cDNA expression library in the yeast one-hybrid screening system and obtained the cDNA clone NT2. Sequence analysis revealed that NT2 is a zinc finger protein consisting of a Kruppel-associated box (KRAB) and is a homologue of human FPM315, which was previously isolated by random cloning and sequencing. The KRAB domain has been found in a number of zinc finger proteins and implicated as a transcriptional repression domain, although few target genes for KRAB-containing zinc finger proteins has been identified. Here, we demonstrate that NT2 functions as a negative regulator of Col11a2. In situ hybridization analysis of developing mouse cartilage showed that NT2 mRNA is highly expressed by hypertrophic chondrocytes but is minimally expressed by resting and proliferating chondrocytes, in an inverse correlation with the expression patterns of Col11a2. Gel shift assays showed that NT2 bound a specific sequence within the 24-bp site of the Col11a2 promoter. We found that Col11a2 promoter activity was inhibited by transfection of the NT2 expression vector in RSC cells, a chondrosarcoma cell line. The expression vector for mutant NT2 lacking the KRAB domain failed to inhibit Col11a2 promoter activity. These results demonstrate that KRAB-zinc finger protein NT2 inhibits transcription of its physiological target gene, suggesting a novel regulatory mechanism of cartilage-specific expression of Col11a2. (+info)

Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements. (6/125)

Expression of the type XI collagen gene Col11a2 is directed to cartilage by at least three chondrocyte-specific enhancer elements, two in the 5' region and one in the first intron of the gene. The three enhancers each contain two heptameric sites with homology to the Sox protein-binding consensus sequence. The two sites are separated by 3 or 4 bp and arranged in opposite orientation to each other. Targeted mutational analyses of these three enhancers showed that in the intronic enhancer, as in the other two enhancers, both Sox sites in a pair are essential for enhancer activity. The transcription factor Sox9 binds as a dimer at the paired sites, and the introduction of insertion mutations between the sites demonstrated that physical interactions between the adjacently bound proteins are essential for enhancer activity. Additional mutational analyses demonstrated that although Sox9 binding at the paired Sox sites is necessary for enhancer activity, it alone is not sufficient. Adjacent DNA sequences in each enhancer are also required, and mutation of those sequences can eliminate enhancer activity without preventing Sox9 binding. The data suggest a new model in which adjacently bound proteins affect the DNA bend angle produced by Sox9, which in turn determines whether an active transcriptional enhancer complex is assembled. (+info)

Collagen XI sequence variations in nonsyndromic cleft palate, Robin sequence and micrognathia. (7/125)

Cleft palate is a common birth defect, but its etiopathogenesis is mostly unknown. Several studies have shown that cleft palate has a strong genetic component. Robin sequence consists of three of the following four findings: micrognathia, glossoptosis, obstructive apnea, and cleft palate. While cleft palate is mainly nonsyndromic, about 80 percent of Robin sequence cases are associated with syndromes. Mutations in genes coding for cartilage collagens II and XI, COL2A1, COL11A1 and COL11A2, have been shown to cause chondrodysplasias that are commonly associated with Robin sequence, micrognathia or cleft palate. We therefore analyzed a cohort of 24 patients with nonsyndromic Robin sequence, 17 with nonsyndromic cleft palate and 21 with nonsyndromic micrognathia for mutations in COL11A2. A total of 23 Robin sequence patients were also analyzed for mutations in COL2A1 and COL11A1. We detected two disease-associated mutations in patients with Robin sequence, an Arg to stop codon mutation in COL11A2 and a splicing mutation in COL11A1. Two putatively disease-associated sequence variations were found in COL11A1 in Robin sequence patients, one in COL11A2 in a patient with micrognathia and one in COL2A1 in two patients with Robin sequence. The results showed that sequence variations in these genes can play a role in the etiology of Robin sequence, cleft palate and micrognathia but are not common causes of these phenotypes. (+info)

Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia. (8/125)

Campomelic dysplasia (CD) is a semilethal osteochondrodysplasia, characterized by skeletal anomalies that include bending of the long bones, and by XY sex reversal. CD results from haploinsufficiency for the transcription factor SOX9, a key regulator at various steps of cartilage differentiation and of early testis development. Two functional domains are so far recognized for SOX9, a high-mobility group (HMG) DNA-binding domain and a C-terminal transactivation domain. We present two CD patients with de novo mutations in a conserved region preceding the HMG domain. A long-term survivor with the acampomelic form of CD has an A76E amino acid substitution, while a severely affected CD patient had an in-frame deletion of amino acid residues 66-75. The conserved domain has been shown to function in the related transcription factor SOX10 as a DNA-dependent dimerization domain. We show that, like SOX10, SOX9 also binds cooperatively as a dimer to response elements in regulatory regions of some target genes such as the cartilage genes Col11a2 and CD-Rap. Dimerization and the resulting capacity to activate promoters via dimeric binding sites is lost in both mutant SOX9 proteins while other features involved in SOX9 function remained unaltered. These findings establish the dimerization domain as the third domain essential for SOX9 function during chondrogenesis. (+info)

The COL11A1 gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a ... XI) collagen cDNA demonstrates that type XI belongs to the fibrillar class of collagens and reveals that the expression of the ... and XI in the growth plate of human rib and fetal bovine epiphyseal cartilage: type XI collagen is restricted to thin fibrils ... type XI, alpha 1". GeneReviews/NCBI/NIH/UW entry on Stickler Syndrome Yoshioka H, Ramirez F (1990). "Pro-alpha 1(XI) collagen. ...

https://en.wikipedia.org/wiki/Collagen,_type_XI,_alpha_1

Type XI collagen also helps maintain the spacing and diameter of type II collagen fibrils. Type II collagen is an important ... Instead, another type of collagen chain replaces pro-alpha2(XI) to form type XI collagen in the vitreous of the eye. COL11A2 ... The COL11A2 gene produces one component of this type of collagen, called the pro-alpha2(XI) chain. Type XI collagen adds ... These mutations prevent the normal assembly of type XI collagen. Type XI collagen plays an important role in the structure and ...

https://en.wikipedia.org/wiki/Collagen,_type_XI,_alpha_2

... chain of type II collagen. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and ... "A COL2A1 mutation in achondrogenesis type II results in the replacement of type II collagen by type I and III collagens in ... type 2 by affecting tissues that are rich in type II collagen. Platyspondylic lethal skeletal dysplasia, Torrance type:Fewer ... chain that cannot be incorporated into type II collagen fibers. As a result, cells make a reduced amount of type II collagen. ...

https://en.wikipedia.org/wiki/Collagen,_type_II,_alpha_1

... collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to ... This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted ... collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". Genomics ... "Entrez Gene: COL12A1 collagen, type XII, alpha 1". Oh SP, Taylor RW, Gerecke DR, et al. (1992). "The mouse alpha 1(XII) and ...

https://en.wikipedia.org/wiki/Collagen,_type_XII,_alpha_1

This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix ... 2002). "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are ... "Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to ... "Entrez Gene: COL18A1 collagen, type XVIII, alpha 1". Pufe T, Kurz B, Petersen W, et al. (2006). "The influence of biomechanical ...

https://en.wikipedia.org/wiki/Collagen,_type_XVIII,_alpha_1

It encodes the alpha chain of type XVII collagen. Collagen XVII is a transmembrane protein, like collagen XIII, XXIII and XXV. ... which in turn causes a type of osteogenesis imperfecta. Collagen, type XVII, alpha 1 has been shown to interact with Keratin 18 ... Collagen XVII is a homotrimer of three alpha1(XVII)-chains and a transmembrane protein in type II orientation. Each 180 kD a- ... 2015). "Mutations in collagen, type XVII, alpha 1 (COL17A1) cause epithelial recurrent erosion dystrophy (ERED)". Hum. Mutat. ...

https://en.wikipedia.org/wiki/Collagen,_type_XVII,_alpha_1

"Entrez Gene: COL8A1 collagen, type VIII, alpha 1". Shuttleworth CA (1998). "Type VIII collagen". Int. J. Biochem. Cell Biol. 29 ... This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major ... Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ... The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the ...

https://en.wikipedia.org/wiki/Collagen,_type_VIII,_alpha_1

"Entrez Gene: COL6A1 collagen, type VI, alpha 1". Bertini E, Pepe G (2002). "Collagen type VI and related disorders: Bethlem ... "Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen". J. Biol. Chem. 272 (42): 26522-9 ... The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that ... 1996). "Type VI collagen mutations in Bethlem myopathy, an autosomal dominant myopathy with contractures". Nat. Genet. 14 (1): ...

https://en.wikipedia.org/wiki/Collagen,_type_VI,_alpha_1

Latvanlehto A, Snellman A, Tu H, Pihlajaniemi T (2003). "Type XIII collagen and some other transmembrane collagens contain two ... Collagen XIII belongs to the transmembranous subfamily of collagens, like collagen XVII, XXIII and XXV. GRCh38: Ensembl release ... 2002). "The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and ... 1998). "Type XIII collagen is identified as a plasma membrane protein". J. Biol. Chem. 273 (25): 15590-7. doi:10.1074/jbc. ...

https://en.wikipedia.org/wiki/Collagen,_type_XIII,_alpha_1

Type XV collagen is known to be a tumor suppressor that can be used to understand tumor cells environment. Type XV collagen ... This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with ... "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed ... Hägg PM, Hägg PO, Peltonen S, Autio-Harmainen H, Pihlajaniemi T (June 1997). "Location of type XV collagen in human tissues and ...

https://en.wikipedia.org/wiki/Collagen,_type_XV,_alpha_1

Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, a collagen component of hyaline cartilage. ... "Entrez Gene: COL9A1 collagen, type IX, alpha 1". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...

https://en.wikipedia.org/wiki/Collagen,_type_IX,_alpha_1

... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... type III collagen is also an important regulator of the diameter of type I and II collagen fibrils. Type III collagen is also ... Type III collagen could also be important in several other human diseases. Increased amounts of type III collagen are found in ... Type III collagen is one of the fibrillar collagens whose proteins have a long, inflexible, triple-helical domain. Type III ...

https://en.wikipedia.org/wiki/Collagen,_type_III,_alpha_1

"Entrez Gene: COL25A1 collagen, type XXV, alpha 1". Kakuyama H, Söderberg L, Horigome K, et al. (2006). "CLAC binds to ... Collagen, type XXV, alpha 1 has been shown to interact with Amyloid precursor protein. GRCh38: Ensembl release 89: ... CLAC-P/collagen type XXV". EMBO J. 21 (7): 1524-34. doi:10.1093/emboj/21.7.1524. PMC 125364. PMID 11927537. " ... Collagen alpha-1(XXV) chain is a protein that in humans is encoded by the COL25A1 gene. COL25A1 is a brain-specific membrane- ...

https://en.wikipedia.org/wiki/Collagen,_type_XXV,_alpha_1

This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with ... other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve ... collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". Genomics ... "Entrez Gene: COL19A1 collagen, type XIX, alpha 1". Yoshioka H, Zhang H, Ramirez F, et al. (1992). "Synteny between the loci for ...

https://en.wikipedia.org/wiki/Collagen,_type_XIX,_alpha_1

"Entrez Gene: COL6A2 collagen, type VI, alpha 2". Bertini E, Pepe G (2002). "Collagen type VI and related disorders: Bethlem ... "Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen". J. Biol. Chem. 272 (42): 26522-9 ... This gene encodes one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective ... 1996). "Type VI collagen mutations in Bethlem myopathy, an autosomal dominant myopathy with contractures". Nat. Genet. 14 (1): ...

https://en.wikipedia.org/wiki/Collagen,_type_VI,_alpha_2

It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of the type IV collagen and plays a role in ... collagen". FEBS Letters. 225 (1-2): 188-94. doi:10.1016/0014-5793(87)81155-9. PMID 3691802. "Entrez Gene: COL4A1 collagen, type ... Type IV collagen is the major structural component of basement membranes, which contains two or three COL4A1 proteins. Thus, ... COL4A1 belongs to the type IV collagen family and contains three domains: a short N-terminal domain, a long triple-helical 7S ...

https://en.wikipedia.org/wiki/Collagen,_type_IV,_alpha_1

... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ... Kypreos KE, Sonenshein GE (1998). "Basic fibroblast growth factor decreases type V/XI collagen expression in cultured bovine ...

https://en.wikipedia.org/wiki/Collagen,_type_V,_alpha_3

Alpha 1 subunit of type VI collagen is the encoded protein. In terms of the diagnosis of Ullrich congenital muscular dystrophy ... It is associated with variants of type VI collagen, it is commonly associated with muscle weakness and respiratory problems, ... Bushby KM, Collins J, Hicks D (2014) Collagen type VI myopathies. Adv Exp Med Biol 802:185-199 "Congenital Muscular Dystrophy ... via ScienceDirect (Subscription may be required or content may be available in libraries.) "COL6A1 collagen type VI alpha 1 [ ...

https://en.wikipedia.org/wiki/Ullrich_congenital_muscular_dystrophy

Collagenopathy, types II and XI Connective tissue disease Coburn, Alvin (1974). Commitment Total. United States of America: ... 54, xi. ISBN 0-8027-0449-2. Collagen disease entry in the public domain NCI Dictionary of Cancer Terms This article ... Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus ... "collagen disease" was coined by Dr. Alvin F. Coburn in 1932, on his quest to discover streptococcal infection as the cause for ...

https://en.wikipedia.org/wiki/Collagen_disease

It is related to the fibrillar collagens: type II, type XI, and type XXIV. Current research suggests that it is made by ... Type XXVII collagen is the protein predicted to be encoded by COL27A1. It was first described by Dr. James M. Pace and his ... v t e (Articles lacking sources from December 2009, All articles lacking sources, Collagens, All stub articles, Protein stubs) ...

https://en.wikipedia.org/wiki/Type_XXVII_collagen

The number of types shows collagen's diverse functionality. Fibrillar (Type I, II, III, V, XI) Non-fibrillar FACIT (Fibril ... of the collagen in the human body is type I collagen. However, as of 2011, 28 types of human collagen have been identified, ... Type XIII, XVII) Microfibril forming (Type VI) Anchoring fibrils (Type VII) The five most common types are: Type I: skin, ... With type I collagen and possibly all fibrillar collagens, if not all collagens, each triple-helix associates into a right- ...

https://en.wikipedia.org/wiki/Collagen

Enhanced deposition of predominantly type I collagen in myocardial disease. J Mol Cell Cardiol. 1990;22:1157-1165 Table 11-2 in ... Clinical history of ischaemic type chest pain lasting for more than 20 minutes Changes in serial ECG tracings Rise and fall of ... have nearly complete tissue specificity and are now the preferred markers for assessing myocardial damage.Heart-type fatty acid ... Archived 2015-11-21 at the Wayback Machine)" Chute, Michael; Aujla, Preetinder; Jana, Sayantan; Kassiri, Zamaneh (2019). "The ...

https://en.wikipedia.org/wiki/Myocardial_infarction_diagnosis

Diagnostic tests include collagen gene-variant testing, collagen typing via skin biopsy, echocardiogram, and lysyl hydroxylase ... type 5 130080: type 8 - unspecified gene, locus 12p13 225310: type 10 - unspecified gene, locus 2q34 608763: Beasley-Cohen type ... It has two types. Type 1 occurs due to variations in the ZNF469 gene. Type 2 is due to variations in the PRDM5 gene. Classical- ... Except for hypermobility (type 3), the most common type of all 10 types, some of the specific variations involved have been ...

https://en.wikipedia.org/wiki/Ehlers–Danlos_syndromes

Perälä M, Savontaus M, Metsäranta M, Vuorio E (1997). "Developmental regulation of mRNA species for types II, IX and XI ... Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. ...

https://en.wikipedia.org/wiki/Collagen,_type_IX,_alpha_3

Using type I collagen nanofibers produced via electrospinning, Shih et al. found that the engineered collagen scaffold showed ... Shih YR, Chen CN, Tsai SW, Wang YJ, Lee OK (November 2006). "Growth of mesenchymal stem cells on electrospun type I collagen ... Nonmineralized organic component (i.e. type 1 collagen), mineralized inorganic component (i.e. hydroxyapatite), and many other ... PCL is a type of biodegradable polyester that can be prepared via ring-opening polymerization of ε-caprolactone using catalysts ...

https://en.wikipedia.org/wiki/Nanofiber

... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... "Entrez Gene: COL5A1 collagen, type V, alpha 1". Mann K (1992). "Isolation of the alpha 3-chain of human type V collagen and ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ...

https://en.wikipedia.org/wiki/Collagen,_type_V,_alpha_1

Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ... integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. 276 (31): 29368-74. doi:10.1074/jbc. ... They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. ... Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells. The DX5 monoclonal ...

https://en.wikipedia.org/wiki/Integrin_alpha_2

Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ... 1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI". Exp ... 1996). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 ... MacDonald TT, Horton MA, Choy MY, Richman PI (1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium ...

https://en.wikipedia.org/wiki/Integrin_alpha-1

The COL11A2 gene is responsible for providing instructions on making one component of the type XI collagen. Type XI collagen is ... which codes for the α2 strand of collagen type XI. It is a collagenopathy, types II and XI disorder. The condition was first ... The mutation of COL11A2 in Weissenbacher-Zweymüller syndrome disrupts the assembly of the type XI collagen molecules. The ... Collagen is found in bone. It is also found in cartilage that makes up most of the skeleton during early development. ...

https://en.wikipedia.org/wiki/Weissenbacher–Zweymüller_syndrome

Cleaves type IV collagen at Ala73-Gln in alpha1(IV) and at Gly7-Leu in alpha2(IV) This endopeptidase is present in the venom of ... "Identification of the cleavage sites by a hemorrhagic metalloproteinase in type IV collagen". Matrix. 10 (2): 91-7. doi:10.1016 ... 8832(11)80175-7. PMID 2374521. Atrolysin+E at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: ...

https://en.wikipedia.org/wiki/Atrolysin_E

Several types of catenins work with N-cadherins to play an important role in learning and memory. Cell-cell adhesion complexes ... Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR (October 2011). "A role for collagen XXIII in cancer cell ... For instance, higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened ... levels of collagen helped facilitate adhesions and anchorage-independent cell growth and provided evidence of collagen XXIII's ...

https://en.wikipedia.org/wiki/Catenin

Due to its many twists and turns, it is a common place for a type of horse colic called an impaction. The small colon is 3.0 to ... Once a tendon is damaged the tendon will always be weaker, because the collagen fibres tend to line up in random arrangements ... As tendons develop they lay down collagen, which is the main structural protein of connective tissue. As tendons pass near bony ... Archived (PDF) from the original on 11 April 2013. Retrieved 1 May 2018. Whittington, Beverly. "Body Parts of the Horse". www. ...

https://en.wikipedia.org/wiki/Equine_anatomy

Fluoride-containing toothpaste can be classified into two types, namely low-fluoride and high-fluoride toothpaste. Low-fluoride ... SDF, in addition to performing the functions of conventional topical fluorides, is suggested to have collagen-conserving ... Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal of Stomatology. 24 (2): 146-147. ISSN 1000- ... 6 (1): 11. doi:10.3390/healthcare6010011. ISSN 2227-9032. PMC 5872218. PMID 29385684. Nóbrega, Diego Figueiredo; Fernández, ...

https://en.wikipedia.org/wiki/Topical_fluoride

... such as expression of several types of collagens and protein vimentin, a part of cytoskeletal filaments. Unlike fibroblasts, ... Fibroblast-like synoviocytes (FLS) represent a specialised cell type located inside joints in the synovium. These cells play a ... 2010). "Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production". Science. 327 (5965): 580- ... The inner layer is mainly composed of two cell types, specialized macrophages (macrophage-like synovial cells) and fibroblast- ...

https://en.wikipedia.org/wiki/Fibroblast-like_synoviocyte

"Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl ... is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous ... 11 (19): 2456-67. doi:10.1101/gad.11.19.2456. PMC 316562. PMID 9334312. Roig J, Tuazon PT, Zipfel PA, Pendergast AM, Traugh JA ... 88 (2): 205-11. doi:10.1016/S0092-8674(00)81841-3. PMID 9008161. S2CID 14205526. Yu HH, Zisch AH, Dodelet VC, Pasquale EB (July ...

https://en.wikipedia.org/wiki/ABL_(gene)

While there may be some validity to the idea that for various types of specific damage detailed below that are by-products of ... Chemical damage to structural proteins can lead to loss of function; for example, damage to collagen of blood vessel walls can ... With respect to specific types of chemical damage caused by metabolism, it is suggested that damage to long-lived biopolymers, ... Horvath S (2013). "DNA methylation age of human tissues and cell types". Genome Biology. 14 (10): R115. doi:10.1186/gb-2013-14- ...

https://en.wikipedia.org/wiki/Senescence

The use of this type of product on a daily basis gradually enhances the exfoliation of the epidermis. This exposes newer skin ... Epidermal growth factor, to stimulate cell renewal and collagen production in the skin, and strengthen elasticity and structure ... p. 11. ISBN 9789240016866. Calasanti, T. (1 September 2007). "Bodacious Berry, Potency Wood and the Aging Monster: Gender and ... 51 (11): 1393-1400. doi:10.3109/13880209.2013.793720. ISSN 1388-0209. PMID 23862588. Magnet, U.; Urbanek, C.; Gaisberger, D.; ...

https://en.wikipedia.org/wiki/Anti-aging_product

Excessive pronation of the foot (over 5 degrees) in the subtalar joint is a type of mechanical mechanism that can lead to ... This lack of blood supply can lead to the degradation of collagen fibers and inflammation. Tightness in the calf muscles has ... It is also a known side effect of fluoroquinolone antibiotics such as ciprofloxacin, as are other types of tendinitis. Swelling ... Increased water content and disorganized collagen matrix in tendon lesions may be detected by ultrasonography or magnetic ...

https://en.wikipedia.org/wiki/Achilles_tendinitis

It is also unlikely that Paleolithic hunter-gatherers were affected by modern diseases of affluence such as type 2 diabetes, ... 19 February 2019). "Exceptionally high δ15N values in collagen single amino acids confirm Neandertals as high-trophic level ... For instance, archaeological evidence from art and bear remains reveals that the bear cult apparently involved a type of ... collagen samples shed new light on their debated diet". Science Daily. Retrieved 21 February 2019. Wilford, John Noble (18 ...

https://en.wikipedia.org/wiki/Paleolithic

CDG syndrome type 1A CDG syndrome type 1B CDG syndrome type 1C CDG syndrome type 2 CDG syndrome type 3 CDG syndrome type 4 CDK4 ... hemolytic anemia Cold contact urticaria Cold urticaria Cole carpenter syndrome Coleman-Randall syndrome Colitis Collagen ... Tooth disease type 1C Charcot-Marie-Tooth disease type 2A Charcot-Marie-Tooth disease type 2B1 Charcot-Marie-Tooth disease type ... disease type 2C Charcot-Marie-Tooth disease type 2D Charcot-Marie-Tooth disease type 4A Charcot-Marie-Tooth disease type 4B ...

https://en.wikipedia.org/wiki/List_of_diseases_(C)

Tuberous sclerosis is also associated with a second type of angiofibroma, adenoma sebaceum, also termed facial angiofibroma, in ... spindle-shaped or star-shaped fibroblasts and ectatic blood vessels in a dense collagen fiber connective tissue background. In ... 54 (11): 1214-25. doi:10.1111/ijd.12980. PMID 26235189. S2CID 5471149. DiCicco B, Johnson W, Allred J, Soldano AC, Ramsdell WM ...

https://en.wikipedia.org/wiki/Koenen's_tumor

There are two types of striated muscle: Cardiac muscle (heart muscle) Skeletal muscle (muscle attached to the skeleton) ... The perimysium organizes the muscle fibers, which are encased in collagen and endomysium, into fascicles. Each muscle fiber ... Based on their contractile and metabolic phenotypes, skeletal muscle can be classified as slow-oxidative (Type I) or fast- ... oxidative (Type II). Cardiac muscle lies between the epicardium and the endocardium in the heart. Cardiac muscle cells ...

https://en.wikipedia.org/wiki/Striated_muscle_tissue

The ISneck domain is a type of neck domain. There are two types of ISneck domain. This first is an ISneck which is interrupted ... Nummelin H, Merckel MC, Leo JC, Lankinen H, Skurnik M, Goldman A (2004). "The Yersinia adhesin YadA collagen-binding domain ... There are several types of head domain. Each domain helps the head to bind to a different component of the extracellular matrix ... There are two types of stalk domain: the FGG domain and the right-handed stalk domain. Structure: The structure of this protein ...

https://en.wikipedia.org/wiki/Trimeric_autotransporter_adhesin

Protein sequencing of the material showed it to be collagen. In November 2010, hunter David Bradt stumbled on an elasmosaur ... There are four major types of habitat within the refuge: river bottom, riparian zones and wetlands, shoreline, and upland ( ... On December 11, 1936, President Roosevelt issued Executive Order 7509, establishing the Fort Peck Game Range. Jurisdiction over ... doi:10.1038/news070409-11. S2CID 83947782. Retrieved November 8, 2017. "New prehistoric sea creature discovered after Montana ...

https://en.wikipedia.org/wiki/Charles_M._Russell_National_Wildlife_Refuge

... mice made deficient in LECT2 using a gene knockout method developed more severe osteoarthritis induced by anti-type II collagen ... and other types of inflammation-related disorders; the metabolic syndrome and diabetes; and various types of liver disease. The ... Mice made deficient in the Lect2 gene were compared to wild-type mice in a model of high fatty acid diet-induced obesity and ... Several cell types or tissues, e.g. osteoblasts, chondrocytes, cardiac tissue, gastrointestinal smooth muscle cells, and ...

https://en.wikipedia.org/wiki/LECT2

A polyproline helix is a type of protein secondary structure which occurs in proteins comprising repeating proline residues. A ... This structure is somewhat similar to that adopted in the fibrous protein collagen, which is composed mainly of proline, ... most commonly in the first residue of a type II β-turn. The "mirror image" PPII backbone dihedral angles (75°, -150°) are ... 2018-11-15). "The Singular NMR Fingerprint of a Polyproline II Helical Bundle". Journal of the American Chemical Society. 140 ( ...

https://en.wikipedia.org/wiki/Polyproline_helix

Collagen fibers have about a 4% elastic zone where fibers stretch out with increased load on the joint. However, exceeding this ... type of cold compress that is activated similarly to a blood pressure cuff) have been effective in reducing swelling and ... Ligaments are tough, inelastic fibers made of collagen that connect two or more bones to form a joint and are important for ... Chronic sprains are caused by repetitive movements leading to overuse.[citation needed] Ligaments are collagen fibers that ...

https://en.wikipedia.org/wiki/Sprain

There are numerous types of liposuction. Some can be described as techniques or modalities. Often surgeons will use two or more ... Referred to as Smart Lipo, this technique uses laser technology to coagulate and tighten the skin and boost collagen ... Referred to as "a vibrating cannula" in research studies, PAL uses a specific type of wand that creates an up and down, ... Liposuction, or simply lipo, is a type of fat-removal procedure used in plastic surgery. Evidence does not support an effect on ...

https://en.wikipedia.org/wiki/Liposuction

... is a type of receptor which binds one or more signaling peptides or signaling proteins. An example ... Asprosin Bombesin Calcitonin Carnosine CART CLIP DSIP Enteroglucagon Formyl peptide GALP GIP GRP Integrin ligands collagens ... 2-11) Galanin-like peptide Galmic Galnon J18 NAX 810-2 Antagonists C7 Galantide (M15) M32 M35 M40 M871 Agonists Galanin Galanin ... Antagonists BIIE-0246 JNJ-5207787 SF-11 Agonists GR-231118 Neuropeptide Y Pancreatic polypeptide Peptide YY Antagonists UR-AK49 ...

https://en.wikipedia.org/wiki/Signaling_peptide_receptor

"Glycated albumin stimulation of PKC-beta activity is linked to increased collagen IV in mesangial cells". The American Journal ... and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gene expression in cultured human vascular smooth ... 13 (11): 2715-22. doi:10.1097/01.ASN.0000033507.32175.FA. PMID 12397041. Kim S, Yu SS, Lee IS, Ohno S, Yim J, Kim S, Kang HS ( ... 176 (11): 6709-16. doi:10.4049/jimmunol.176.11.6709. PMID 16709830. Wang N, Verna L, Hardy S, Forsayeth J, Zhu Y, Stemerman MB ...

https://en.wikipedia.org/wiki/AP-1_transcription_factor

There are various types of hepatocytes that are used in these devices. Porcine hepatocytes are often used due to ease of ... Hepatocytes are suspended in a gel solution such as collagen, which is injected into a series of hollow fibers. In the case of ... A liver support system or diachysis is a type of therapeutic device to assist in performing the functions of the liver. Such ... Basically, three different types of supportive therapies have been developed: bio-artificial, artificial and hybrid liver ...

https://en.wikipedia.org/wiki/Liver_support_system

... such as the Aquaflow collagen wick, ologen Collagen Matrix, or Xenoplast glaucoma implant. Laser-assisted NPDS is performed ... The most common type is open-angle (wide angle, chronic simple) glaucoma, in which the drainage angle for fluid within the eye ... A number of types of glaucoma surgeries may be used in people who do not respond sufficiently to other measures. Treatment of ... Since then, several types of implants have followed on from the original: the Baerveldt tube shunt, or the valved implants, ...

https://en.wikipedia.org/wiki/Glaucoma

Chernousov MA, Stahl RC, Carey DJ (1996). "Schwann cells secrete a novel collagen-like adhesive protein that binds N-syndecan ... this deactivated gene is found across many cancer types in this study to be the underlying cause of the disease. Tne CUX1 gene ... 13 (11): 3761-74. doi:10.1091/mbc.E02-06-0349. PMC 133590. PMID 12429822. Malsam J, Satoh A, Pelletier L, Warren G (2005). " ... 11 (12): 1552-66. doi:10.1111/j.1600-0854.2010.01123.x. PMID 20874812. S2CID 20424336. Lievens PM, Tufarelli C, Donady JJ, ...

https://en.wikipedia.org/wiki/CUTL1

Compared to Type I PEL, Type II PEL occurs more often in older individuals, is less often associated with EBV, and more often ... tightly woven collagen fibers) which forms around breast implants. Less frequently, individuals present with extracavitary ... than the malignant cells in Type I PEL. The response to treatment and prognosis of Type II PEL is poor but may be somewhat ... Type II PEL may be a less severe disease than Type I PEL, at lease in certain cases. PEL is generally resistant to cancer ...

https://en.wikipedia.org/wiki/Primary_effusion_lymphoma

"Establishing collagen quality criteria for sulphur isotope analysis of archaeological bone collagen". Archaeological and ... Many methods tracking these types of changes have been developed using a variety of skeletal series. For instance, in children ... Though bone collagen is abundant in skeletal remains, less than 1% of the tissue is made of sulfur, making it imperative that ... The same cannot be said for human bone collage, as δ18O values in collagen seem to be impacted by drinking water, food water, ...

https://en.wikipedia.org/wiki/Bioarchaeology

It can also be used as an edible coating for dates, producing another type of snack. Ejiao is also used for applying di mo, a ... "Extraction and identification of collagen-derived peptides with hematopoietic activity from Colla Corii Asini". Journal of ... In China ejiao is a traditional medicine used for different types of illnesses. An amount of 5 to 10 grams may be dissolved in ... Murray, Jessica (2019-11-21). "World's donkeys being 'decimated' by demand for Chinese medicine". The Guardian. Lesté-Lasserre ...

https://en.wikipedia.org/wiki/Donkey-hide_gelatin

Swierczynski A, Ton-That H (September 2006). "Type III pilus of corynebacteria: Pilus length is determined by the level of its ... "A collagen-binding adhesin, Acb, and ten other putative MSCRAMM and pilus family proteins of Streptococcus gallolyticus subsp. ... "A second pilus type in Streptococcus pneumoniae is prevalent in emerging serotypes and mediates adhesion to host cells". ... 75 (11): 5399-404. doi:10.1128/IAI.00663-07. PMC 2168291. PMID 17785477. Manetti AG, Zingaretti C, Falugi F, Capo S, Bombaci M ...

https://en.wikipedia.org/wiki/Sortase

... and homocitrulline-containing peptides related to type I and II collagen telopeptides. Arthritis Research & Therapy, 17(1):2 ... 1988;11(3):261-5. Kato T, Sano M: Effect of ammonium chloride on homocitrulline and homoarginine synthesis from lysine. J ... 2001 Mar 24;131(11-12):139-4. Kraus LM, Elberger AJ, Handorf CR, Pabst MJ, Kraus AP Jr: Urea-derived cyanate forms epsilon- ... 2013; 11:224 Dionisi Vici C, Bachmann C, Gambarara M, Colombo JP, Sabetta G: Hyperornithinemia-hyperammonemia-homocitrullinuria ...

https://en.wikipedia.org/wiki/Homocitrulline

Joint contracture of the shoulder has also been found to be at a higher incidence in type two diabetics, which may lead to ... The inflammatory process causes synovial cells to multiply, increasing collagen formation and fluid production within the bursa ... "Vascular endothelial growth factor 121 and 165 in the subacromial bursa are involved in shoulder joint contracture in type II ... 8 (2): 102-11. doi:10.1016/S1058-2746(99)90001-0. PMID 10226960. Butcher JD, Salzman KL, Lillegard WA (1996). "Lower extremity ...

https://en.wikipedia.org/wiki/Subacromial_bursitis

Type XI collagenopathies: Mutations in procollagen XI genes (COL11A1 and COL11A2) cause Stickler dysplasia and ... Type 2 collagen group. This includes the following conditions:. * Achondrogenesis type 2 ... Infant with Beemer-type (left) and an infant with Majewski-type (right) short-rib syndrome (SRS). Note severe micrognathia/ ... Type II collagenopathies: Mutations in the procollagen II gene (COL2A1) cause achondrogenesis type II (Langer-Saldino dysplasia ...

https://emedicine.medscape.com/article/943343-clinical

Collagen face cream can instantly plump and hydrate your skin, with even better long term results that will have you looking ... This cream is excellent for most skin types, but if you have extremely dry skin, ráya also makes collagen cream with ... If youre searching for a collagen cream thats natural, paraben free and cruelty free, ráya collagen - elastin cream is a ... Collagen water, in theory, reduces the size of the collagen particles for easier absorption. ...

https://heavy.com/beauty/2019/02/collagen-face-cream/

Structural organization of distinct domains within the non-collagenous N-terminal region of collagen type XI. / Gregory, Kate E ... Structural organization of distinct domains within the non-collagenous N-terminal region of collagen type XI. In: Journal of ... Structural organization of distinct domains within the non-collagenous N-terminal region of collagen type XI. Journal of ... title = "Structural organization of distinct domains within the non-collagenous N-terminal region of collagen type XI", ...

https://ohsu.pure.elsevier.com/en/publications/structural-organization-of-distinct-domains-within-the-non-collag

XI) chain. Learn about this gene and related health conditions. ... gene provides instructions for making a component of type XI ... Type XI collagen also helps maintain the spacing and width (diameter) of another type of collagen molecule, type II collagen. ... The COL11A1 gene provides instructions for making a component of type XI collagen called the pro-alpha1(XI) chain. Collagens ... When the abnormal chain is incorporated into collagen molecules, it creates defective type XI collagen. The abnormal collagen ...

https://medlineplus.gov/genetics/gene/col11a1/

The collagen triple helix is a ubiquitous biomacromolecule used in acidic aqueous solutions as precursor in the fabrication of ... The collagen triple helix is a ubiquitous biomacromolecule used in acidic aqueous solutions as precursor in the fabrication of ... with previous theoretical and experimental studies but also able to be used to explore new routes for non-equilibrium collagen ... Type I collagen from Jellyfish Catostylus mosaicus for biomaterial applications. ACS Biomater Sci Eng. (2018) 4:2115-25. doi: ...

https://www.frontiersin.org/articles/10.3389/fphy.2019.00088/full

Collagen degradation (Homo sapiens) * Collagen type XI degradation by MMP1,2,3,9 (Homo sapiens) * Cleaved collagen type XI ... Cleaved collagen type XI fibril [extracellular region] (Homo sapiens) * Cleaved tropocollagen type XI [extracellular region] ( ... Cleaved collagen type XI fibril [extracellular region] (Homo sapiens) * Cleaved tropocollagen type XI [extracellular region] ( ... Cleaved tropocollagen type XI [extracellular region] (Homo sapiens) * Cleaved collagen alpha-2(XI) chains [extracellular region ...

https://reactome.org/content/detail/R-HSA-2470611

Cleaved collagen type XI fibril [extracellular region] (Mus musculus) * Cleaved tropocollagen type XI [extracellular region] ( ... Cleaved collagen alpha-2(XI) chains [extracellular region] (Mus musculus) * 4-Hyp 5-Gal-Hyl collagen alpha-2(XI) chain C-term ... 5-Gal-Hyl collagen alpha-2(XI) chain [extracellular region] 4-Hyp Glu-Gal-Hyl collagen alpha-2(XI) chain [extracellular region] ... Collagen alpha-2(XI) chain N-term fragment [extracellular region] 4-Hyp 5-Hyl collagen alpha-2(XI) chain N-term fragment [ ...

https://www.reactome.org/content/detail/R-MMU-2470635

... types IX and XI) have been described. They are more likely to be found in association with antibodies to type II collagen in ... Various studies find circulating antibodies to cartilage-specific collagen types II, IX, and XI to be present in 30%-70% of ... cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive ... Antibodies to type II collagen in relapsing polychondritis. N Engl J Med. 1978 Nov 30. 299(22):1203-7. [QxMD MEDLINE Link]. ...

https://www.medscape.com/answers/331475-167229/when-was-relapsing-polychondritis-rp-first-identified

Name: collagen, type XI, alpha 1. Synonyms: C530001D20Rik. Type: Gene. Species: Mus musculus (mouse) ... When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J ...

https://www.mmrrc.org/catalog/sds.php?mmrrc_id=41013

Collagen Complex (Type II Collagen). One clinical trial of collagen, 1200 mg per day, showed improved pain levels in joints ... The amount used in this study was 40 mg undenatured type II collagen 9with 10 mg bioactive undenatured type II collagen). [12] ... Another study found type II collagen effective for reducing joint pain and treating rheumatoid arthritis and osteoarthritis. ... "Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial." ...

https://www.supplementcritic.com/arnold-iron-pack-reviews/

Collagen Casing, Cellulose Casing, Plastic Casing, Fibrous Casing, Value Added Casing, Textile Casing, and Net Casing) and ... 5. Artificial Casings Market, by Type. 5.1. Introduction. 5.2. Collagen Casing. 5.2.1. Edible Collagen Casing. 5.2.2. Non- ... Table 5 Global Collagen Casings Market Size, by Type, 2017-2025 (USD Million). Table 6 Collagen Casings Market Size, by Country ... Artificial Casings Market by Type (Collagen Casing, Cellulose Casing, Plastic Casing, Fibrous Casing, Value Added Casing, ...

https://www.marketresearch.com/Meticulous-Research-v4061/Artificial-Casings-Type-Collagen-Casing-12643166/

... matrix metalloproteinase-derived fragments of type II collagen) and hsCRP (high sensitive C-reactive protein) were quantified ... monoclonal antibody was developed as a biomarker of chondrocyte hypertrophy through measurement of type X collagen (ColX). The ... The data suggest that chondrocyte hypertrophy and subsequent collagen X fragmentation seem to be increased in a subset of ... Differential susceptibility of type X collagen to cleavage by two mammalian interstitial collagenases and 72-kDa type IV ...

https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-15-309

It also contains vitamins A, D and E and helps to boost collagen production, which promotes elasticity and helps combat ... Argan is also a great carrier oil for the face, as its not too heavy or light, making it suitable for all skin types. "Its ... What are the best carrier oils for my skin type?. There are many carrier oils, but youll want to figure out which is best for ... Oily and acne-prone skin types can sparingly use jojoba oil, which has anti-inflammatory properties. "Jojoba oil is very ...

https://www.goodhousekeeping.com/beauty-products/a36491686/carrier-oils-for-skincare/

Mayne, R.; Brewton, R.G.; Mayne, P.M.; Baker, J.R. Isolation and characterization of the chains of type V/type XI collagen ... Mutational landscape and significance across 12 major cancer types. Nature 2013, 502, 333-339. [Google Scholar] [CrossRef] [ ... This type of paper provides an outlook on future directions of research or possible applications. ... likely a driver mutation shown to occur in many cancer types, including breast cancer [25,29]. The clonal variant groups B and ...

https://www.mdpi.com/2072-6694/11/10/1566

4.11 Collagen. 4.11.1 Nutrient Overview. 4.11.2 Clinical Trials Suggesting the Benefits of Collagen in Various Indications. ... Which are the popular product types in the global nutraceuticals market?. *What are the various stages in the value chain of ... Figure 12: Collagen Health Concern Areas. Figure 13: Aloe Vera Health Concern Areas. Figure 14: Zinc Health Concern Areas. ... Table 14: Types of Nutraceuticals. Table 15: Nutraceuticals Market: Nutraceuticals for Various Indications. Table 16: Global ...

https://www.imarcgroup.com/global-nutraceuticals-market

Formulated with hydrolysed collagen and lemon verbena leaf extract, this lightweight ampoule helps retain moisture in the skin ... All Skin Types - Moisture Line. Oily Skin - Snail Line. Dry Skin - Collagen Line. Toners. ... Formulated with hydrolysed collagen and lemon verbena leaf extract, this lightweight ampoule helps retain moisture in the skin ... Village 11 Factory Collagen Ampoule - Cosmopolitan India. By :Gwang Bio Care 0 comments ...

https://www.gwangbiocare.com/blogs/news/village-11-factory-collagen-ampoule

We found the 11 best brightening face washes that deliver instant and long-term gratification in the radiance department. Click ... But choosing a face wash that plays nicely with your skin type, pays heed to your concerns, and concurs with your goals is of ... The brilliant combination of eco-friendly jojoba beads, hyaluronic acid, vegetable collagen, and vitamin B5 keeps skin firm and ... Its safe for all skin types and keeps the skin at peace by gently polishing away dulling dead skin cells and buildup, ...

https://www.whowhatwear.com/brightening-face-washes

Collagen Type I (Type I Collagen)IBA 08/2002. 1. Complementary DNA (cDNA)IBA 12/2001. ...

https://www.curehunter.com/public/authorSummary-Yasui,%20T.do

Cleavage of type XI collagen fibers by gelatinase and by extracts of osteoarthritic canine cartilage. Smith, G.N., Hasty, K.A ... purified from culture medium of MDCK cells by affinity chromatography on gelatin-sepharose was tested against type XI collagen ... Retinoic acid-induced type II collagen degradation does not correlate with matrix metalloproteinase activity in cartilage ... Shedding of membrane type matrix metalloproteinase 5 by a furin-type convertase: a potential mechanism for down-regulation. ...

https://www.wikigenes.org/e/gene/e/281308.html

... collagen type I usually occurs as a heterotrimer (two α1 chains and one α2 chain). Inside the cell, the role of the C-terminal ... but how this occurs for different forms of the same collagen type is so far unknown. Here, by structural and mutagenic analysis ... Heterotrimers of collagen I (two α1 chains, one α2 chain) are crucial for the normal function of multiple tissues and organs. ... Here the authors show the molecular basis of both homotrimerization (three α1 chains) and heterotrimerization of collagen I ...

https://www.nature.com/articles/ncomms14671?error=cookies_not_supported

Eleven rats from each group were sacrificed at 4 and 8 weeks. Supraspinatus tendons were evaluated histologically or ... Both supraspinatus tendons of the experimental groups had increases in cellularity and collagen disorganization and changes in ... Publication types * Research Support, Non-U.S. Govt * Research Support, U.S. Govt, P.H.S. ...

https://pubmed.ncbi.nlm.nih.gov/9850782/?dopt=Abstract

... maintenance of chondrocyte differentiation and proliferation in type I collagen gels. J Orthop Res. 2004;22(2):446-55 ... type II collagen, aggrecan and N-Cadherin were up-regulated in cartilage. SOX9 is the key transcription factor for ... Halofuginone attenuates osteoarthritis by inhibition of TGF-beta activity and H-type vessel formation in subchondral bone. ANN ... Evaluation of chondrocyte growth in the highly porous scaffolds made by fused deposition manufacturing (FDM) filled with type ...

https://medsci.org/v18p3808.htm

N-telopeptides of type I collagen (NTx) and ratio of urinary 8-hydroxy-2-deoxyguanosine (8-OHdG) to creatinine. Plasma and ... Park HM, Cho MH, Cho Y, Kim SY: Royal jelly increases collagen production in rat skin after ovariectomy. J Med Food. 2012, 15 ( ... It is then converted to T through androstenedione by 3β-hydroxysteroid dehydrogenase type 2 (3β-HSD2) and 17β-hydroxysteroid ... Testosterone is an anabolic steroid and has been used to treat several types of anemia. ...

https://link.springer.com/article/10.1186/1475-2891-11-77

After spontaneous chondrogenesis, CPC spheroids were entirely positive for N-cadherin, collagen type II and type VI, and ... 12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z/,,/g,,g transform=matrix(.013,0,0,-0.013,31.809,0 ... 11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z/,,/g,,/svg,,/span,). ... collagen type II; (d) collagen type VI; (e) aggrecan; (f) chondroitin sulfate. Bar size: 20 μm. (g) Control of nonspecific ...

https://www.hindawi.com/journals/sci/2017/7053465/

Type & Select Correct Answer. Type in at least one full word to see suggestions list ... generates reactive O2 species that destroys collagen ... Type & Select Correct Answer. Type in at least one full word to ... Type & Select Correct Answer. Type in at least one full word to see suggestions list ... Type & Select Correct Answer. Type in at least one full word to see suggestions list ...

https://www.orthobullets.com/basic-science/9002/bone-cells

It actually starts on the inside, with collagen. According to research, by the age of 30 we only have about 50% of the collagen ... The most superior collagen for radiant glowing skin. The foundation of youthful, supple skin is about so much more than ... and is the type of collagen used in our GLOW Hydrolysed Collagen Powder. The other types of collagen are involved in other ... Collagen is the most abundant protein in the human body with over 28 known types. Of these, Type 1 collagen is involved in skin ...

https://www.swiish.com/collections/wellness/products/glow-chocolate-hydrolysed-collagen

I used collagen type II before my pregnancy but I was advised through my OB that I shouldnt take it during pregnancy and ... Marine Collagen. Collagen is a staple supplement for busy moms who want to stay in top health and keep up with their kids. But ... Collagen is an essential protein. Improves Digestion. Collagen helps to heal and seal our gut by lining the gut and aiding in ... What is Collagen?. Collagen is the protein building block of all your connective tissues, including your bones, muscles, skin, ...

https://modernalternativemama.com/2016/06/23/7-reasons-every-mama-needs-supplement-collagen/?replytocom=1023993

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"Fibrochondrogenesis results from mutations in the COL11A1 type XI collagen gene." Am J Hum Genet. 2010 November 12; 87 (5): 708 ...

https://www.bcm.edu/people-search/carlos-bacino-17844

The cross-links result in the formation of very strong type XI collagen fibers. (medlineplus.gov)
The annulus is formed of 15-25 concentric lamellae with collagen fibers running parallel within each lamella and oriented approximately 60° to the vertical axis. (wheelessonline.com)
2,3,8,9 The orientation of the collagen fibers alternates in adjacent lamellae, and the lamellae are bound and held together via elastic fibers. (wheelessonline.com)
10 The outer layers of the annulus contain elongated thin fibroblastic-like cells which are aligned parallel to the collagen fibers. (wheelessonline.com)
Picrosirius red (PSR) staining viewed under polarized light microscopy is the standard method to evaluate the organization of collagen fibers in tissues. (elsevier.com)
This and other cellular interactions with the fibers appear to trigger the collagen buildup in the lungs known as fibrosis or asbestosis and, over a longer period, produce cancer as well. (cdc.gov)
The physiological role of cartilage depends on the integrity of the matrix, made mainly by type 11 collagen fibers, proteoglycans and non collagen glycoproteins. (uchile.cl)
These types all create relatively long fibers (compared to body cells). (afemo.org)
Fibroblasts are cells in connective tissue which produce collagen and other fibers. (seraphinaskincare.com)

Collagen XI is a heterotrimeric molecule found predominantly in heterotypic cartilage fibrils, where it is involved in the regulation of fibrillogenesis. (elsevier.com)
Mature collagen molecules arrange themselves into long, thin fibrils that form stable interactions (cross-links) with one another in the spaces between cells (the extracellular matrix). (medlineplus.gov)
The arrangement and size of type II collagen fibrils is essential for the normal structure of these tissues. (medlineplus.gov)
One of the main families of ECM proteins are the collagens (currently 28 different types in humans) among which the fibrillar collagens (types I, II, III, V and XI) constitute the classical periodically banded fibrils seen by electron microscopy 2 . (nature.com)
The inner gelatinous core, nucleus pulposus, contains primarily type II collagen fibrils oriented in a random fashion, interspersed within a proteoglycan-rich interfibrillar matrix. (wheelessonline.com)

id":271106736188,"handle":"gut-health","updated_at":"2022-12-05T20:45:04+11:00","published_at":"2022-09-27T16:02:49+10:00","sort_order":"manual","template_suffix":"collection-no-banner","published_scope":"global","title":"Gut Health","body_html":"Ease bloating, boost energy and improve gut health. (swiish.com)
id":271106637884,"handle":"hair","updated_at":"2022-12-05T19:40:10+11:00","published_at":"2022-09-27T16:02:33+10:00","sort_order":"manual","template_suffix":"collection-no-banner","published_scope":"global","title":"Hair","body_html":"\u003cp\u003e\u003cmeta charset=\"utf-8\"\u003eTarget hair growth and health with scientifically formulated SWIISH supplements that deliver results. (swiish.com)
u003c\/p\u003e"},{"id":271106572348,"handle":"skin","updated_at":"2022-12-05T19:20:17+11:00","published_at":"2022-09-27T15:57:39+10:00","sort_order":"manual","template_suffix":"collection-no-banner","published_scope":"global","title":"Skin","body_html":"\u003cmeta charset=\"utf-8\"\u003e\n\u003cp\u003eSay hello to skin that glows. (swiish.com)
Preprints (earlier versions) of this paper are available at https://preprints.jmir.org/preprint/36339 , first published January 11, 2022 . (jmir.org)

TWNT-1 cells showed differential functions of HSC, including uptake of acetylated low-density lipoproteins and synthesis of collagen type I and hepatocyte growth factor. (lww.com)
Serum markers of collagen degradation, collagen synthesis, and their ratio were not elevated in aged rats with task performance. (cdc.gov)
This study uncovers new insights into EWAT adaptation after BS with decreased collagen crosslink and synthesis as well as an increased degradation together with enhanced blood vessel density providing, simultaneously, higher stiffness and more ductility. (unav.edu)
Collagen synthesis analysis has historically been performed by culturing dermal fibroblasts obtained during skin biopsy. (medscape.com)
Argireline reduces wrinkles associated with repeated facial contractions, and Matrixyl 3000 encourages collagen synthesis for firmer, smoother, and more supple-looking skin. (milamoursi.com)
u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eArgireline:\u003c\/strong\u003e Reduces the appearance of wrinkles caused by facial contractions\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMatrixyl 3000:\u003c\/strong\u003e Encourages collagen synthesis for firmer, smoother, and more supple-looking skin. (milamoursi.com)
The natural role of these peptides as found in human plasma includes supporting a wide range of skin health functions like maintaining normal immune function, collagen synthesis, fibroblast production and anti-inflammatory responses. (sweetcorea.com)
the latter a biomarker of collage type II synthesis) were also attenuated by ibuprofen. (cdc.gov)

This weakens skin structure, results in the degradation of collagen and elastin and impairs the skin's barrier function. (eminenceorganics.com)

The search for the holy grail of beautiful young looking skin boils down to a simple protein called collagen. (heavy.com)
Some of these mutations change single protein building blocks (amino acids) or delete a small number of amino acids from the pro-alpha1(XI) chain. (medlineplus.gov)
Other mutations cause segments of DNA to be skipped when the protein is made, resulting in an abnormally short pro-alpha1(XI) chain. (medlineplus.gov)
The levels of C-Col10, C2M (matrix metalloproteinase-derived fragments of type II collagen) and hsCRP (high sensitive C-reactive protein) were quantified by ELISAs in serum of 271 OA patients stratified by Kellgren-Lawrence (KL) score 0-4. (biomedcentral.com)
EDS causes a mutation in the body's collagen, a protein in the body that essentially acts as the glue for connective tissues in the ligaments, skin, joints, blood vessels and organs. (cedarville.edu)
These increases in procollagen expression were accompanied by increases in collagen translation and increases in procollagen-1 mRNA without any demonstrable increase in procollagen-1 protein stability. (marshall.edu)
But lately, most know Alpha Prime for their AP Prime Bites Protein Brownies … which have a fair amount of collagen in them. (priceplow.com)
In fact, collagenous proteins account for about 25% to 35% of all the protein in your body, making it your body's most common type of protein. (priceplow.com)
Since collagen is the most abundant protein not just in human beings, but in all animals, [3,4] eating animals "nose to tail," as most traditional cultures did, naturally furnished the people in those cultures with a relatively high dietary intake of collagen. (priceplow.com)
Collagen is one of the most numerous healthy protein in your body, and also it's a huge part of your tendons, skin, bones, teeth, muscular tissues as well as tendons. (afemo.org)
Additional proteins have joined this exclusive club of adipocyte-specific secretory proteins since then, including adipokines such as resistin ( 11 , 12 ) and acylation-stimulating protein ( 13 ), as well as the recently described visfatin ( 14 , 15 ) and retinol-binding protein-4 ( 16 ). (diabetesjournals.org)
Also, see the documentation for the primary exam data for Lab 11 C-Reactive Protein. (cdc.gov)
or a protein that is less able to bind to collagen. (cdc.gov)

Type XI collagen is normally found in cartilage, a tough but flexible tissue that makes up much of the skeleton during early development. (medlineplus.gov)
Type II collagen is an important component of the vitreous and cartilage. (medlineplus.gov)
The evidence for an autoimmune etiology includes pathological findings of infiltrating T cells, the presence of antigen-antibody complexes in affected cartilage, cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive regimens most often suppress the disease. (medscape.com)
Various studies find circulating antibodies to cartilage-specific collagen types II, IX, and XI to be present in 30%-70% of patients with relapsing polychondritis. (medscape.com)
Autoantibodies to minor cartilage-specific collagens (ie, types IX and XI) have been described. (medscape.com)
On the other hand, hydrogels, commonly used in scaffold-based cartilage tissue engineering, are responsible to impair cell-cell interaction [ 11 ]. (hindawi.com)
A fibrillar collagen found primarily in interstitial CARTILAGE . (nih.gov)
According to that, this work was focused on the biochemical analysis of the extracellular matrix articular cartilages from scapular-humerus, ulnar-humerus and radial-humerus articulations of chicken, aiming to analyze small proteoglycans and identify the type of glycosaminoglycans present in each cartilage. (uchile.cl)
Northampton, MA (11/12/19) - Perfect Type II Collagen (Cartilage) is now the world's first 100% bovine cartilage collagen to receive the Glyphosate Residue Free Certification from the Detox Project. (perfectsupplements.com)
Type II collagen is thinner than kind I, as well as is used in cartilage material all bunched up like springs for shock absorption. (afemo.org)
Collagen in your cartilage is the mechanical reason why joints do not just fracture and break whenever you leap or run. (afemo.org)

Apr.11, 2019 - UAE building giant Arabtec Construction has teamed up with Robert Bird Group, American University of Dubai (AUD) and local firm 3Dvincy Creations, to establish the AUD Center for 3D concrete printing & digital construction. (3ders.org)
Apr.11, 2019 - Researchers at North Carolina State University have developed a way to improve the characteristics of artificial tissues by using ultrasound to align living cells during the biofabrication process. (3ders.org)

Il s'agissait d'une étude transversale analytique de type cas témoins avec appariement 1/1 (1 cas pour 1 témoin) sur une période six mois allant du 01er Janvier 2021 au 30 Juin 2021, au centre médico-social du port autonome de Douala. (bvsalud.org)

Lose that heavy feeling with our highly effective SWIISH gut cleansing fibre, greens powder, marine collagen and more for the ultimate digestive reset. (swiish.com)
Add to your routine the best marine collagen or bovine collagen for added support. (swiish.com)
Our SWIISH marine collagen, bovine collagen and greens powder help achieve radiant, glowing skin. (swiish.com)
But you can also try their Marine Collagen capsules or Pure Collagen if you want to keep it simple! (priceplow.com)

The most superior bioavailable bovine collagen for healthy, glowing skin that radiates from within. (swiish.com)
The rats, which had a small portion of their back skin clipped, were provided with either a jellyfish collagen sponge or a bovine collagen sponge and were observed for at least a month. (naturalnews.com)
After a month of testing, researchers found that host rats were able to accept jellyfish collagen better than bovine collagen. (naturalnews.com)

Experts believe that this is because collagen generates cells such as fibroblasts and keratinocytes which sanitize the wound and encourage the growth of new blood vessels to speed up the process of healing. (naturalnews.com)

Trimerization of the procollagen C-propeptides initiates intracellular assembly of the procollagen molecule while extracellular proteolytic cleavage of the N- and C-propeptides controls collagen fibril formation. (nature.com)
Our in vivo results demonstrated that hypoxic BMSCs possessed better histological and biomechanical properties than those of normoxic BMSCs, as evidenced by histological scores, quantitative analysis of immunohistochemical staining for Col-1a1 and Tnmd, the range and average of collagen fibril diameters and patellar tendon biomechanical tests. (researchsquare.com)

We found decreased gene expression levels of collagens and Lox together with increased elastin and Mmps mRNA levels in EWAT after BS, which were also associated with the biomechanical properties. (unav.edu)
With time, the skin's strong and flexible matrix begins to weaken and hyaluronic acid, elastin and collagen naturally deplete. (eminenceorganics.com)
Here are a few signs of aging that develop due to the loss of hyaluronic acid, collagen and elastin over time. (eminenceorganics.com)
Hyaluronic acid, collagen and elastin are what keeps the skin plump, firm and elastic. (eminenceorganics.com)
At the heart of the brand is our MM-5 Complex, an expertly calibrated system of plant-derived stem cells, peptides, collagen, elastin, amino acids, and innovative ingredients to address all signs of aging. (milamoursi.com)
u003c\/p\u003e\n\u003ch5\u003eIngredients\u003c\/h5\u003e\n\u003cp\u003e\u003cstrong\u003eKey Ingredients\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003eMM-5 Complex:\u003c\/strong\u003e Transforms skin with a powerful multi-peptide complex that works in synergy with amino acids, plant-derived stem cells, collagen and elastin. (milamoursi.com)

Collagens are molecules that provide structure and strength to the connective tissues that support the body's muscles, joints, organs, and skin. (medlineplus.gov)
The abnormal collagen weakens connective tissues, impairing the formation of bones throughout the skeleton and causing changes in the eye and inner ear that lead to vision and hearing problems. (medlineplus.gov)
Defective collagen disrupts the normal development of connective tissues in many different parts of the body, which leads to the varied signs and symptoms of Stickler syndrome. (medlineplus.gov)
While a homotrimeric form (three α1 chains) has been reported in embryonic tissues as well as in diseases (cancer, fibrosis, genetic disorders), collagen type I usually occurs as a heterotrimer (two α1 chains and one α2 chain). (nature.com)
The reason why collagen is so abundant is that it's your body's structural backbone , the extracellular matrix [1] that gives your tissues shape. (priceplow.com)
The collagen helps hold it all together - support collagen and support your connective tissues! (priceplow.com)
GC are activated by the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) and this regulates cell function (e.g. growth, development, signalling) in tissues such as fat, muscle and liver but the effects of 11β-HSD1 in skin are poorly understood. (leeds.ac.uk)
1% sodium bicarbonate (NaHCO ) dis- ions in tissues such as collagen or muscle. (who.int)

These small-chain amino acids (also known as peptides) are absorbed by the body to help regenerate lost collagen such as the collagen that occurs naturally in the deepest layers of skin known as the dermis. (swiish.com)
What we can do however, is 'hydrolyze' the collagen, which indicates it's broken down into much smaller items (' peptides') by water, making it useful by your body. (afemo.org)
Collagen Complicated offers easy-to-digest hydrolyzed collagen peptides. (afemo.org)
What is the difference in between hydrolyzed collagen and also collagen peptides? (afemo.org)
Collagen supplements are otherwise identified as "hydrolyzed collagen" or "collagen peptides," however they're the same. (afemo.org)

Collagen helps to heal and seal our gut by lining the gut and aiding in digestion of proteins and amino acids. (modernalternativemama.com)
One of the most common proteins in your body is collagen. (manageyourage.com)
Collagen proteins are long chains of amino acids. (afemo.org)
Vital Proteins Collagen Energy Shots. (shakerdesignproject.com)

The pro-alpha1(XI) chain combines with two other collagen chains, pro-alpha2(XI) and pro-alpha1(II), to form a triple-stranded procollagen molecule. (medlineplus.gov)
Type XI collagen also helps maintain the spacing and width (diameter) of another type of collagen molecule, type II collagen. (medlineplus.gov)
Each procollagen molecule is a trimer, where, depending on the genetic type, the three polypeptide chains are either identical (homotrimers, as in collagens II and III) or at least one of the chains is distinct (heterotrimers, as in collagens I, V and XI). (nature.com)
The collagen contains a triple helix molecule made up of the amino acids glycine, proline , and hydroxyproline . (priceplow.com)
The triple helix molecular structure is what makes collagenous tissue like skin supple and taut: these helices are shaped in such a way that they can fold over each other effortlessly at the structural level, without breaking the bonds between them or degrading the collagen molecule of which they're a part. (priceplow.com)

We think collagen face cream is a must-have in your beauty arsenal, especially if you're already noticing fine lines and wrinkles. (heavy.com)
It also contains vitamins A, D and E and helps to boost collagen production, which promotes elasticity and helps combat wrinkles. (goodhousekeeping.com)
Now with dry skin, you might suffer cracks, the formation of wrinkles, and dry patches which can accentuate if a wrong type of setting powder is used. (pucebeauty.com)

The collagen triple helix is a ubiquitous biomacromolecule used in acidic aqueous solutions as precursor in the fabrication of artificial compact bone and cornea and in tissue engineering. (frontiersin.org)
Studies have revealed that jellyfish contain collagen , which can assist in tissue regrowth and help with the healing process. (naturalnews.com)
The material can be used for any type of wound, except for third-degree burns and injuries which have deteriorated into burnt dead tissue. (naturalnews.com)
It is also used to distinguish between type I and type III collagen in tissue sections. (elsevier.com)
Variations in the concentration and types of components may result in special biomechanical properties to the tissue. (uchile.cl)
That implies they do not get the amino acids (specifically hydroxyproline, glycine, and also proline) that are discovered in collagen yet not much in muscular tissue meat. (afemo.org)
To study the effect of tap water `softening' (i.e. calcium extraction) on H&E stains, 5 sets of slides from 30 different paraffin-embedded human pathologic tissue blocks were prepared in the same way except for washing with 5 different types of water. (who.int)

Each chain has three domains: a short triple helix domain flanked by a bigger globular domain (NC1 domain) at the carboxyl end and a short non-collagenous domain (NC2 domain) at the amino end [ 11 ]. (biomedcentral.com)
Our collagen has been through a process known as hydrolysis whereby long-chain amino acids have been broken down using water into smaller molecular components called small-chain amino acids. (swiish.com)
But collagen is far, far more than that: it contains a suite of certain amino acids that are absolutely crucial for optimal metabolic and cardiovascular health, and are generally lacking in the SAD. (priceplow.com)
Together, these three aminos account for nearly 60% of all the amino acids in collagen. (priceplow.com)

VitaPost Collagen Complex could have terrific advantages supporting the body's upkeep of the skeleton, especially in females that are undertaking all-natural hormonal changes. (afemo.org)

Read more to discover why collagen is so important and the benefits of collagen production. (manageyourage.com)
What are the Benefits of Collagen Supplements? (afemo.org)

Immunohistochemistry will also be used to visualise changes in wound healing, inflammation and collagen remodelling. (leeds.ac.uk)

Based on these findings, we propose that MBG directly induces increases in collagen expression by fibroblasts, and we suggest that this may be important in the cardiac fibrosis seen with experimental renal failure. (marshall.edu)
When we can encourage the growth of fibroblasts, we can encourage the production of collagen, and when we are talking anti aging skincare, more collagen is always a good thing. (seraphinaskincare.com)

Alpha Prime Supps has launched three different collagen supplements, including the C3 Collagen that also includes full doses of Carnitine and CLA. (priceplow.com)

Both supraspinatus tendons of the experimental groups had increases in cellularity and collagen disorganization and changes in cell shape compared with control tendons. (nih.gov)
Collagen has a major role in the structural organization of tendons. (elsevier.com)
The aim of this study was to clarify whether collagen types I and III can be distinguished by PSR staining in rat Achilles tendons, using double immunohistochemistry as the positive control. (elsevier.com)

The effect of dietary collagen on managing digestive symptoms is currently lacking in the literature. (jmir.org)
second, the study explored the effect of an 8-week daily supplementation of 20 g dietary collagen peptide (Peptan) on digestive symptoms. (jmir.org)

Many people don't eat bones, skin, as well as connective cells- the parts of pets which contain collagen. (afemo.org)

Sadly for those of us who have hit (and long since passed) peak collagen production at 25, it might feel like we're doomed to saggy, baggy, crepy skin. (heavy.com)
According to Heather Wilson, a licensed esthetician and brand development director at InstaNatural , a clean beauty company focused on natural and botanical formulas, "with a topical collagen product, people should expect an increase in moisture which can help the skin appear less dull and more plump upon application. (heavy.com)
What are the best carrier oils for my skin type? (goodhousekeeping.com)
There are many carrier oils, but you'll want to figure out which is best for your skin type first. (goodhousekeeping.com)
The Good Housekeeping Institute asked top dermatologists for everything you need to know about carrier oils, including which are best for use in skincare for every skin type so you'll be on your way to having glowing and healthy skin . (goodhousekeeping.com)
According to Adebola Dele-Michael, M.D. , a dermatologist in New York City, this is a safe go-to to use on your face, no matter what your skin type. (goodhousekeeping.com)
It's also known for its ability to penetrate deep into the skin, therefore boosting moisture and collagen levels. (goodhousekeeping.com)
Formulated with hydrolysed collagen and lemon verbena leaf extract, this lightweight ampoule helps retain moisture in the skin, improving elasticity and texture. (gwangbiocare.com)
But choosing a face wash that plays nicely with your skin type, pays heed to your concerns, and concurs with your goals is of utmost importance in the quest for healthy, balanced skin. (whowhatwear.com)
Learn why adding collagen may be the answer to your energy and skin toning needs. (modernalternativemama.com)
Collagen comes to the rescue of dead skin by aiding in repair and supplying new skin cells. (modernalternativemama.com)
Collagen is the bedrock of your hair, skin and nails. (modernalternativemama.com)
Collagen dressings are also structured in a way as to stay compressed without necessarily feeling too tight around the skin, so the dressing will not stick to dried-up areas of the wound. (naturalnews.com)
Most people's first association when they hear the word collagen is skin , as collagen supplementation is most often undertaken to improve a person's skin health, and thus appearance. (priceplow.com)
Well, your skin is the largest organ in your body, and although it does contain a little water, the vast majority of it - about 80% of it - is actually collagen . (priceplow.com)
When collagen diminishes, so does the moisture levels and the natural bounce of the skin, which is why you must try this collagen anti-aging night cream ASAP. (stylecraze.com)
If yes, then be rest assured for L'Oreal Paris Collagen Moisture Filler is a great anti-aging night cream for sensitive skin too. (stylecraze.com)
Glucocorticoid (GC) steroid hormones (commonly used to treat a range of inflammatory disorders) cause many adverse effects in skin including thinning, collagen loss, impaired wound healing and increased infection risk. (leeds.ac.uk)
Not sure what your skin type is? (lookfantastic.com.hk)
Use cosmetics such as toners or moisturizers designed for your skin type to continue your acne treatment. (foodpharmacy.blog)
Designed for instant and extended results for men and women of all ages, all skin types, and all skin tones, this formula will have you sexy in a flash. (foodpharmacy.blog)
Silky yet deeply hydrating for all skin types, this collagen-promoting moisturizer reveals a more youthful-looking complexion thanks to the magic of Adipofill'in™, a wrinkle-filler to help plump and lift lines and creases. (milamoursi.com)
Collagen offers your skin toughness and also strength. (afemo.org)
Collagen supplements are not only helpful for your skin but likewise for your hair, nails, as well as joints. (afemo.org)
Researches have ended that supplementing with collagen can also raise skin hydration. (afemo.org)
UVA and UVB can damage collagen fibres which results in the speeding up skin ageing. (siyavula.com)
As a defence against UV radiation, the body tans when exposed to moderate (depending on skin type) levels of radiation by releasing the brown pigment melanin. (siyavula.com)
The reticular layer contains thicker, compact collagen, and the adnexal structures of the skin such as sweat glands, hair follicles, and sebaceous glands. (plasticsurgerykey.com)
HYDRATE, BRIGHTEN & SMOOTH FINE LINES: Our unique, non-abrasive, leave-on exfoliant is gentle enough for daily use on all skin types. (antiagingcreamfacts.com)
Suitable for all skin types, including sensitive. (antiagingcreamfacts.com)
Re-Generate Fibroblast Growth Cream is excellent for all skin types, including post peel/treatment. (seraphinaskincare.com)

The COL11A1 gene provides instructions for making a component of type XI collagen called the pro-alpha1(XI) chain. (medlineplus.gov)
At least seven mutations in the COL11A1 gene have been identified in people with fibrochondrogenesis type 1, a disorder of bone growth characterized by severe skeletal abnormalities, hearing loss, and vision loss. (medlineplus.gov)
Some cases of fibrochondrogenesis type 1 result from a combination of COL11A1 gene mutations. (medlineplus.gov)
In at least two reported cases, fibrochondrogenesis type 1 has been caused by combinations of COL11A1 gene mutations that completely eliminate the production of the pro-alpha1(XI) chain. (medlineplus.gov)
When Stickler syndrome results from COL11A1 gene mutations, it is classified as type II. (medlineplus.gov)

Now when a new mommy asks me what prenatal and other supplements she should take during pregnancy, I always mention grabbing a high-quality collagen supplement . (modernalternativemama.com)
Collagen production declines with age, making it even more important to supplement as we age. (modernalternativemama.com)
Collagen is a staple supplement for busy moms who want to stay in top health and keep up with their kids. (modernalternativemama.com)
In keeping with the company's mission of offering the best for every single person , Alpha Prime has made a good effort to develop a collagen supplement for everybody - above and beyond the Brownies! (priceplow.com)
Participation involved 2 weeks of baseline tracking (digestive symptoms, mood, stool, and lifestyle) using an app, followed by 8 weeks of tracking and taking 20 g collagen peptide supplement split into 2 dosages per day. (jmir.org)
The use of a 20 g daily collagen peptide supplement may reduce bloating and improve mild digestive symptoms in otherwise healthy female adults in the absence of any other dietary or lifestyle interventions. (jmir.org)
Northampton, MA (11/25/20) - Perfect Multi-Organs is now the world's first and only multi-organ glandular supplement to receive the Glyphosate Residue Free Certification from the Detox Project. (perfectsupplements.com)
This article will certainly help you determine which collagen supplement is best for you. (afemo.org)
Here are some actions to adhere to when looking for a high quality collagen supplement. (afemo.org)

Collagens begin as rope-like procollagen molecules that are each made up of three chains. (medlineplus.gov)
When the abnormal chain is incorporated into collagen molecules, it creates defective type XI collagen. (medlineplus.gov)
Researchers speculate that a loss of this chain changes the structure of type XI collagen molecules and disrupts its ability to form cross-links. (medlineplus.gov)
All of these changes impair the production or assembly of type XI collagen molecules. (medlineplus.gov)
Fibrillar collagen molecules are synthesized as precursors, procollagens, with large propeptide extensions. (nature.com)
Fibrillar collagen molecules are synthesized in precursor form, procollagens, consisting of a rod-like central triple-helical region ( ∼ 300 kDa) with globular propeptide extensions at both the N- ( ∼ 50 kDa) and C- ( ∼ 90 kDa) termini ( Fig. 1 ). (nature.com)

We can boost our personal collagen with supplements (more on that at the end of this article) and we can turn to moisturizers like collagen face cream, which really can make a noticeable difference. (heavy.com)
That's the context for Alpha Prime's collagen line: as we'll see, collagen is perhaps one of the most indispensable health and wellness supplements in existence, and is of particular importance for people who follow a post-industrial eating pattern like the Standard American Diet (aptly abbreviated as SAD! (priceplow.com)
So if the 5 grams of collagen in the Prime Bites Brownies aren't enough for you (and for most people, it isn't), the heads up - Alpha Prime Supps has launched a trifecta of collagen supplements ! (priceplow.com)
Book an appointment with Medical Age Management to find out what collagen supplements we recommend and more! (manageyourage.com)
There are many different types of collagen supplements on the marketplace today. (afemo.org)
That requires collagen supplements? (afemo.org)

Marinobufagenin Stimulates Fibroblast Collagen Production and Causes F" by Jihad Elkareh, David J. Kennedy et al. (marshall.edu)
We performed the following studies to examine whether MBG might directly stimulate cardiac fibroblast collagen production. (marshall.edu)

Type I Collagen is composed of three left-handed polypeptide helices (denoted by [α1(I)] 2 [α2(I)]) twisted together to yield a right-handed triple helix. (frontiersin.org)

Type X collagen (ColX) is a well-established marker for hypertrophic chondrocytes differentiation, which is a non-fibrillar collagen consisting of three identical alpha 1 chains. (biomedcentral.com)
Inside the cell, the role of the C-terminal propeptides is to gather together the correct combination of three α chains during molecular assembly, but how this occurs for different forms of the same collagen type is so far unknown. (nature.com)

These results show how the C-propeptide of the α2 chain has specifically evolved to permit the appearance of heterotrimeric collagen I, the major extracellular building block among the metazoa. (nature.com)

However, the molecular mechanisms determining homo- or heterotrimerization of these fibrillar collagens remain unknown. (nature.com)

El colágeno de tipo XI es un heterotrímero que contiene subunidades alfa 1 (XI), alfa 2 (XI) y alfa 3 (XI). (bvsalud.org)
O papel fisiológico da cartilagem depende da integridade dessa matriz, formada em geral por fibras de colágeno, principalmente do tipo 11, proteoglicanos e glicoproteínas não colagênicas. (uchile.cl)

In the present study, 84% of patients had good compliance with collagen dressings which were similar to study conducted by Nayak et al. (who.int)

Lethal types of congenital skeletal dysplasia include achondrogenesis, homozygous achondroplasia, chondrodysplasia punctata (recessive form), camptomelic dysplasia, congenital lethal hypophosphatasia, perinatal lethal type of osteogenesis imperfecta, thanatophoric dysplasia, and short-rib polydactyly syndromes. (medscape.com)
Osteogenesis imperfecta (OI) is a disorder of bone fragility chiefly caused by mutations in the COL1A1 and COL1A2 genes, which encode type I procollagen. (medscape.com)
The width of biopsy cores, the width of the cortex, and the volume of cancellous bone are decreased in all types of osteogenesis imperfecta. (medscape.com)

When collagen is defective, this "glue" becomes like rubber, causing these parts of the body to function improperly. (cedarville.edu)

Researchers have found that antibodies to type II collagen are present during acute relapsing polychondritis episodes and that the levels correlate with the severity of the episode. (medscape.com)
They are more likely to be found in association with antibodies to type II collagen in patients with relapsing polychondritis. (medscape.com)
Another study found type II collagen effective for reducing joint pain and treating rheumatoid arthritis and osteoarthritis. (supplementcritic.com)
Glycine found in collagen delivers energy to your cells, and increases muscle production. (modernalternativemama.com)
In a study published in the Journal of Biomedical Materials, researchers discovered that the collagen found in jellyfish was safe for human use and that it had the potential to be used in treating wounds. (naturalnews.com)
Results were compared with conventional dressing, and we found that collagen is a better dressing material for wound healing. (who.int)
4 Four major cell types are found in the epidermis, including keratinocytes (80%), melanocytes, Langerhans cells, and Merkel cells. (plasticsurgerykey.com)

Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits. (nih.gov)

Specifically, one copy of the gene has a mutation that prevents the production of any functional pro-alpha1(XI) chain, and the other copy has a mutation that results in an abnormal version of the pro-alpha1(XI) chain. (medlineplus.gov)
Bethlem myopathy (BM) and Ullrich Congenital Muscular Dystrophy (DMCU) result from a mutation in collagen type VI. (bvsalud.org)

The condition is associated with injury to dermal collagen, granulomatous inflammation, and ulceration. (medscape.com)

Consequently, numerous promising applications of biomimetic fabrication of collagenous biomaterials [ 9 - 11 ] in conjunction with the availability of precursor play a central role in the drive to create the bioinspired collagen-based materials. (frontiersin.org)

Collagen Complex (Type II Collagen). (supplementcritic.com)
Apricot Vegan Collagen Line contains an exclusive patent that has 70% fresh apricot extract which helps us formulate the unique Apricot Collagen Complex. (sweetcorea.com)

The glycine in collagen also helps the liver digest toxic substances. (modernalternativemama.com)

After spontaneous chondrogenesis, CPC spheroids were entirely positive for N-cadherin, collagen type II and type VI, and aggrecan and chondroitin sulfate. (hindawi.com)

Anti-GBM antibodies interact with the GBM glycoproteins, almost exclusively the epitope of the noncollagenous domain (NC1) of the α3 chain of type IV collagen. (medscape.com)

Colágeno fibrilar que se encuentra principalmente en el CARTÍLAGO intersticial. (bvsalud.org)

Collagen Type XI

Collagen

Collagen Type I

Contacts with fibrils containing collagen I, but not collagens II, IX, and XI, can destabilize the cartilage phenotype of chondrocytes. (1/125)

Articular cartilage repair using a tissue-engineered cartilage-like implant: an animal study. (2/125)

COL11A1 in FAP polyps and in sporadic colorectal tumors. (3/125)

Expression of collagen and aggrecan genes in normal and osteoarthritic murine knee joints. (4/125)

A Kruppel-associated box-zinc finger protein, NT2, represses cell-type-specific promoter activity of the alpha 2(XI) collagen gene. (5/125)

Adjacent DNA sequences modulate Sox9 transcriptional activation at paired Sox sites in three chondrocyte-specific enhancer elements. (6/125)

Collagen XI sequence variations in nonsyndromic cleft palate, Robin sequence and micrognathia. (7/125)

Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia. (8/125)

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Collagen, type XI, alpha 1

Collagen, type XI, alpha 2

Collagen, type II, alpha 1

Collagen, type XII, alpha 1

Collagen, type XVIII, alpha 1

Collagen, type XVII, alpha 1

Collagen, type VIII, alpha 1

Collagen, type VI, alpha 1

Collagen, type XIII, alpha 1

Collagen, type XV, alpha 1

Collagen, type IX, alpha 1

Collagen, type III, alpha 1

Collagen, type XXV, alpha 1

Collagen, type XIX, alpha 1

Collagen, type VI, alpha 2

Collagen, type IV, alpha 1

Collagen, type V, alpha 3

Ullrich congenital muscular dystrophy

Collagen disease