Collagen Type VIII: A non-fibrillar collagen originally found in DESCEMET MEMBRANE. It is expressed in endothelial cell layers and in tissues undergoing active remodeling. It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains.Factor VIII: Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Collagen Type III: A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.Glycogen Storage Disease Type VIII: An x-linked recessive hepatic glycogen storage disease resulting from lack of expression of phosphorylase-b-kinase activity. Symptoms are relatively mild; hepatomegaly, increased liver glycogen, and decreased leukocyte phosphorylase are present. Liver shrinkage occurs in response to glucagon.Collagen Type IV: A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.Collagen Type II: A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.Descemet Membrane: A layer of the cornea. It is the basal lamina of the CORNEAL ENDOTHELIUM (from which it is secreted) separating it from the CORNEAL STROMA. It is a homogeneous structure composed of fine collagenous filaments, and slowly increases in thickness with age.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Hemophilia A: The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.Refrigeration: The mechanical process of cooling.Insurance, Disability: Insurance designed to compensate persons who lose wages because of illness or injury; insurance providing periodic payments that partially replace lost wages, salary, or other income when the insured is unable to work because of illness, injury, or disease. Individual and group disability insurance are two types of such coverage. (From Facts on File Dictionary of Health Care Management, 1988, p207)United States Social Security Administration: An independent agency within the Executive Branch of the United States Government. It administers a national social insurance program whereby employees, employers, and the self-employed pay contributions into pooled trust funds. Part of the contributions go into a separate hospital insurance trust fund for workers at age 65 to provide help with medical expenses. Other programs include the supplemental social security income program for the aged, blind, and disabled and the Old Age Survivors and Disability Insurance Program. It became an independent agency March 31, 1995. It had previously been part of the Department of Health, Education, and Welfare, later the Department of Health and Human Services. (From United States Government Manual, 1994-95)Social Security: Government sponsored social insurance programs.ThiomalatesFlax: A plant genus of the family LINACEAE that is cultivated for its fiber (manufactured into linen cloth). It contains a trypsin inhibitor and the seed is the source of LINSEED OIL.Linseed Oil: The fixed oil obtained from the dried ripe seed of linseed, Linum usitatissimum (L. Linaceae). It is used as an emollient in liniments, pastes, and medicinal soaps, and in veterinary medicine as a laxative. It is also called flaxseed oil. (Dorland, 28th ed)Fuchs' Endothelial Dystrophy: Disorder caused by loss of endothelium of the central cornea. It is characterized by hyaline endothelial outgrowths on Descemet's membrane, epithelial blisters, reduced vision, and pain.Corneal Dystrophies, Hereditary: Bilateral hereditary disorders of the cornea, usually autosomal dominant, which may be present at birth but more frequently develop during adolescence and progress slowly throughout life. Central macular dystrophy is transmitted as an autosomal recessive defect.Endothelium, Corneal: Single layer of large flattened cells covering the surface of the cornea.Descemet Stripping Endothelial Keratoplasty: A surgical procedure or KERATOPLASTY involving selective stripping and replacement of diseased host DESCEMET MEMBRANE and CORNEAL ENDOTHELIUM with a suitable and healthy donor posterior lamella. The advantage to this procedure is that the normal corneal surface of the recipient is retained, thereby avoiding corneal surface incisions and sutures.Keratoplasty, Penetrating: Partial or total replacement of all layers of a central portion of the cornea.Integrins: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.Physiological Phenomena: The functions and properties of living organisms, including both the physical and chemical factors and processes, supporting life in single- or multi-cell organisms from their origin through the progression of life.Metabolic Networks and Pathways: Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Poultry: Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Foot: The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.Mice, Inbred DBAHSP47 Heat-Shock Proteins: Basic glycoprotein members of the SERPIN SUPERFAMILY that function as COLLAGEN-specific MOLECULAR CHAPERONES in the ENDOPLASMIC RETICULUM.Arthritis, Experimental: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.ArthritisMice, Inbred C57BLArthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Hepatocytes: The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.History of MedicineAlbumins: Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.Kupffer Cells: Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.Evolution, Planetary: Creation and development of bodies within solar systems, includes study of early planetary geology.Collagen Type VII: A non-fibrillar collagen involved in anchoring the epidermal BASEMENT MEMBRANE to underlying tissue. It is a homotrimer comprised of C-terminal and N-terminal globular domains connected by a central triple-helical region.Epidermolysis Bullosa Acquisita: Form of epidermolysis bullosa characterized by trauma-induced, subepidermal blistering with no family history of the disease. Direct immunofluorescence shows IMMUNOGLOBULIN G deposited at the dermo-epidermal junction.Epidermolysis Bullosa Dystrophica: Form of epidermolysis bullosa characterized by atrophy of blistered areas, severe scarring, and nail changes. It is most often present at birth or in early infancy and occurs in both autosomal dominant and recessive forms. All forms of dystrophic epidermolysis bullosa result from mutations in COLLAGEN TYPE VII, a major component fibrils of BASEMENT MEMBRANE and EPIDERMIS.Epidermolysis Bullosa: Group of genetically determined disorders characterized by the blistering of skin and mucosae. There are four major forms: acquired, simple, junctional, and dystrophic. Each of the latter three has several varieties.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Blister: Visible accumulations of fluid within or beneath the epidermis.
Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy. (1/44)Corneal clarity is maintained by its endothelium, which functions abnormally in the endothelial dystrophies, leading to corneal opacification. This group of conditions includes Fuchs' endothelial dystrophy of the cornea (FECD), one of the commonest indications for corneal transplantation performed in developed countries, posterior polymorphous dystrophy (PPCD) and the congenital hereditary endothelial dystrophies (CHED). A genome-wide search of a three-generation family with early-onset FECD demonstrated significant linkage with D1S2830 (Z(max) = 3.72, theta = 0.0). Refinement of the critical region defined a 6-7 cM interval of chromosome 1p34.3-p32 within which lies the COL8A2 gene. This encodes the 703 amino acid alpha2 chain of type VIII collagen, a short-chain collagen which is a component of endothelial basement membranes and which represented a strong candidate gene. Analysis of its coding sequence defined a missense mutation (gln455lys) within the triple helical domain of the protein in this family. Mutation analysis in patients with FECD and PPCD demonstrated further missense substitutions in familial and sporadic cases of FECD as well as in a single family with PPCD. This is the first description of the molecular basis of any of the corneal endothelial dystrophies or of mutations in type VIII collagen in association with human disease. This suggests that the underlying pathogenesis of FECD and PPCD may be related to disturbance of the role of type VIII collagen in influencing the terminal differentiation of the neural crest derived corneal endothelial cell. (+info)
Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis. (2/44)Type VIII collagen is upregulated after vessel injury, and this collagen has been implicated in both smooth muscle cell migration and angiogenesis. This study examines the temporal and spatial pattern of expression of type VIII collagen in porcine coronary vessels at specific time points after balloon angioplasty. In situ hybridization studies demonstrated that collagen VIII messenger ribonucleic acid (mRNA) was markedly elevated in the neoadventitia at 3 days post-angioplasty. By 14 days, elevated collagen VIII message was seen mainly in the neointima and this expression decreased to background levels by 90 days. The distribution of collagen VIII protein, detected using immunohistochemistry, was similar but the up-regulation lagged behind the mRNA increase by a few days. Pre-treatment of sections with pepsin highlighted variations in the organization and appearance of extracellular collagen VIII containing structures in both injured and normal vessels. New vessel formation was evident in the neoadventitia after 3 days, but there was no colocalization of type VIII collagen immunostaining with that of von Willebrand factor (a marker of endothelial cells) in the neoadventitia. These data show that up-regulation of collagen VIII in the neoadventitia is an important early marker of the coronary arterial response to injury, and is not associated with new vessel formation. (+info)
Human corneal epithelial cell viability and morphology after dilute alcohol exposure. (3/44)PURPOSE: To determine the effect of dilute alcohol on human corneal epithelial cellular morphology and viability. Dilute alcohol is used for epithelial removal during photorefractive keratectomy (PRK) and laser subepithelial keratomileusis (LASEK). METHODS: Corneal epithelial sheets harvested from human eyes after alcohol application during PRK were examined by light and electron microscopy (specimens I-IV). In addition, tissue cultures of human epithelial sheets were monitored for epithelial migration and attachment (specimens V-VII). To determine the effect of dilute alcohol on epithelial cell viability, simian virus (SV)40-immortalized human corneal epithelial cells were exposed to dilute alcohol in distilled water (EtOH-H2O) or to keratinocyte serum-free medium (EtOH-KSFM) for incubation periods of 20 to 45 seconds and concentrations of 10% to 70%. Cell membrane permeability and intracellular esterase activity were analyzed by calcein-acetoxymethyl ester (AM)/ethidium homodimer assay. TdT-mediated dUTP nick-end labeling (TUNEL) assay was used to detect apoptotic cells at 0, 8,12, 24, and 72 hours. RESULTS: Electron microscopy showed varying degrees of basement membrane alterations after alcohol application, including disruptions, discontinuities, irregularities, and duplication (specimens I-IV). Cellular destruction and vacuolization of basal epithelial cells associated with absent basement membrane were also observed (specimen III). One of three cultured epithelial sheets showed attachment and outgrowth in the tissue culture until day 15 (specimen V). Twenty-second exposure of cultured immortalized human cells to various concentrations of EtOH-H2O showed significant reduction of viable cells when EtOH-H2O concentration exceeded 25% (P = 0.005). Increasing the duration of application of 20% EtOH-H2O beyond 30 seconds resulted in a significant reduction in viable cells (69.69% +/- 16.34% at 30 seconds compared with 2.14% +/- 2.29%, 10.45% +/- 7.11%, and 11.09% +/- 15.73% at 35, 40, and 45 seconds, respectively; P = 0.01). TUNEL assay of cultured human corneal epithelial cells exposed to 20% EtOH-H(2)O for 20 and 40 seconds showed maximal labeling at 24 hours (58.05% +/- 33.10%) and 8 hours (94.12% +/- 1.21%), respectively. Exposure to 20% EtOH-KSFM for 20 and 40 seconds resulted in substantially lower TUNEL positivity (3.51% +/- 0.20% at 24 hours and 7.11% +/- 0.49% at 8 hours). CONCLUSIONS: The viability and electron microscopic findings in the basement membrane zone showed significant variation after treatment of the epithelium in vivo with dilute alcohol. The application of dilute alcohol on the monolayer of cultured corneal epithelial cells resulted in increasing cell death in a dose- and time-dependent manner. (+info)
Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. (4/44)Estrogen exerts a variety of important physiological effects, which have been suggested to be mediated via the two known estrogen receptors (ERs), alpha and beta. Three-month-old ovariectomized mice, lacking one or both of the two estrogen receptors, were given estrogen subcutaneously (2.3 micro g/mouse per day) and the effects on different estrogen-responsive parameters, including skeletal effects, were studied. We found that estrogen increased the cortical bone dimensions in both wild-type (WT) and double ER knockout (DERKO) mice. DNA microarray analysis was performed to characterize this effect on cortical bone and it identified four genes that were regulated by estrogen in both WT and DERKO mice. The effect of estrogen on cortical bone in DERKO mice might either be due to remaining ERalpha activity or represent an ERalpha/ERbeta-independent effect. Other effects of estrogen, such as increased trabecular bone mineral density, thymic atrophy, fat reduction and increased uterine weight, were mainly ERalpha mediated. (+info)
Identification of genes induced in regenerating Xenopus tadpole tails by using the differential display method. (5/44)To identify candidate gene(s) involved in the tail regeneration of Xenopus laevis tadpoles, we used the differential display method to isolate four genes (clones 1, 2, 13a, and 13b) whose expression is induced in regenerating tadpole tails. Among them, clones 13a and 13b were found to encode the Xenopus homologues of the alpha1 chain of type XVIII collagen and neuronal pentraxin I, respectively. Expression of clone 2 and neuronal pentraxin I genes increased dramatically in the blastema 3 days after amputation, whereas that for the clone 1 and type XVIII collagen genes was induced gradually after amputation. In situ hybridization revealed that the neuronal pentraxin I gene is expressed specifically in the regenerating tail epidermis but not in the normal tail epidermis or the most distal margin of the tail blastema, suggesting that it has a tissue-inductive role in tail regeneration. Expression of the four genes was induced in the limb and in the tail blastema, suggesting that they are involved in the regeneration of both organs. Finally, expression of clone 2 and neuronal pentraxin I genes was scarce during embryonic stages in comparison to the tail blastema, suggesting that their main functions are in organ regeneration. Our results demonstrate unique features of spatial and temporal gene expression patterns during Xenopus tadpole tail regeneration. (+info)
Molecular targets for tumour progression in gastrointestinal stromal tumours. (6/44)BACKGROUND AND AIMS: The distinction between benign and malignant gastrointestinal stromal tumours (GISTs) is often unclear at the clinical and histopathology levels. GISTs are believed to arise from the stem cells of Cajal. In order to define genetic biomarkers and identify target genes related to GIST progression, we analysed and compared benign and malignant GISTs with verified follow up data using cDNA expression arrays. METHODS: Eight genes were frequently overexpressed in malignant GISTs and their overexpression was confirmed using quantitative real time reverse transcription-polymerase chain reaction. These genes included ezrin (villin 2 (VIL2)), collagen 8 alpha 1 subunit (COL8A1), G2/mitotic specific cyclin B1 (CCNB1), high mobility group protein (HMG2), TSG101 tumour susceptibility protein, CENP-F kinetochore protein, protein tyrosine kinase 2 (FAK), and protein kinase DYRK2. To test these genes in a clinical setting, we obtained diagnostic samples of 16 additional GISTs that were classified at diagnosis as benign, malignant, and uncertain malignant potential (UMP). RESULTS: There was remarkable gene overexpression in all malignant GISTs. Statistical analyses revealed significant correlations between overexpression of several gene pairs in malignant GISTs. We found the strongest correlations (rho>0.70) among the significant correlations (p<0.01) between CCNB1-CENP-F (rho = 0.87) and CCNB1-FAK (rho = 0.73). Gene expression of the UMP GISTs suggested two different groups. Three UMP GISTs had gene expression consistent with malignant tumours and their follow up data revealed that indeed these patients had recurrences later on. On the other hand, UMP GISTs that had low gene expression levels continued free of disease for several years. CONCLUSIONS: These results provide insight into the oncogenesis of GISTs and suggest that testing the expression profile of a number of genes may segregate GISTs into groups of different tumour behaviour. (+info)
Expression and supramolecular assembly of recombinant alpha1(viii) and alpha2(viii) collagen homotrimers. (7/44)Collagen VIII is an extracellular matrix macromolecule comprising two polypeptide chains, alpha1(VIII) and alpha2(VIII), that can form homotrimers in vitro and in vivo. Here, recombinant collagen VIII was expressed to study its supramolecular assembly following secretion. Cells transfected with alpha1(VIII) or alpha2(VIII) assembled and secreted homotrimers that were stable in denaturing conditions and had a molecular mass of approximately 180 kDa on SDS-PAGE gels. Co-transfection with prolyl 4-hydroxylase generated homotrimers with stable pepsin-resistant triple-helical domains. Size fractionation of native recombinant collagen VIII molecules expressed with or without prolyl 4-hydroxylase identified urea-sensitive high molecular mass assemblies eluting in the void volume of a Superose 6HR 10/30 column and urea-resistant assemblies of approximately 700 kDa, all of which were composed of homotrimers. Immunofluorescence analysis highlighted the extracellular deposition of recombinant alpha1(VIII)(3), alpha2(VIII)(3), and co-expressed alpha1(VIII)(3)/alpha2(VIII)(3). Microscopy analysis of recombinant collagen VIII identified rod-like molecules of 134 nm in length that assembled into angular arrays with branching angles of approximately 114 degrees and extensive networks. Based on these data, we propose a model of collagen VIII assembly in which four homotrimers form a tetrahedron stabilized by central interacting C-terminal NC1 trimers. Tetrahedrons may then act as building blocks of three-dimensional hexagonal lattices generated by secondary interactions involving terminal and helical sequences. (+info)
Endostatin promotes the anabolic program of rabbit chondrocyte. (8/44)Endostatin is a natural occurred angiogenesis inhibitor derived from collagenXVIII. So far its function during the angiogenesis process of bone formation and arthropathy has not been well studied yet. The present study addresses the function of endostatin in rabbit articular chondrocytes (RAC). We found that endostatin can promote RAC adhesion and spreading as well as its proliferation. In monolayer cultured RAC, CollagenII, TIMP1 and collagenXVIII transcription were up regulated by endostatin while collagenI and MMP9 were down regulated. Moreover collagenXVIII and endostatin antigens are present at synovial fluid. These findings indicate new function of endostatin as a homeostatic factor in cartilage metabolism. (+info)
TY - JOUR. T1 - Collagen VIII is expressed by vascular smooth muscle cells in response to vascular injury. AU - Sibinga, Nicholas E S. AU - Foster, Lauren C.. AU - Hsieh, Chung Ming. AU - Perrella, Mark A.. AU - Lee, Wen Sen. AU - Endege, Wilson O.. AU - Sage, E. Helene. AU - Lee, Mu En. AU - Haber, Edgar. PY - 1997. Y1 - 1997. N2 - To identify genes involved in vascular remodeling, we applied differential mRNA display analysis to the rat carotid artery balloon injury model. One polymerase chain reaction product showing increased expression at days 2 to 14 after vascular injury was nearly identical to the mouse α1 chain of type VIII collagen, a heterotrimeric short-chain collagen of uncertain function expressed by a limited number of cell types. By Northern analysis, expression of both chains of the type VIII collagen heterotrimer increased: collagen α1 (VIII) mRNA expression was almost 4-fold higher than control by 7 days after vascular injury, and collagen α2 (VIII) mRNA expression reached ...
Collagen VIII alpha 1兔多克隆抗体(ab100988)可与人样本反应并经WB实验严格验证。中国75%以上现货，所有产品均提供质保服务，可通过电话、电邮或微信获得本地专属技术支持。
A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets.
View mouse Col8a2 Chr4:126286793-126314330 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Mehta, J.S., Vithana, E.N., Tan, D.T.H., Yong, V.H.K., Aung, T., Yam, G.H.F., Law, R.W.K., Pang, C.P. (2008). Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset fuchs endothelial corneal dystrophy. Investigative Ophthalmology and Visual Science 49 (1) : 184-188. [email protected] Repository. https://doi.org/10.1167/iovs.07- ...
Purpose : Fuchs endothelial corneal dystrophy (FECD) is an autosomal dominant disease with assorted variations in expression and penetrance. The expansion of a CTG trinucleotide repeat (TNR) in a different intron of transcription factor 4 (TCF4) has commonly been detected in FECD patients, and the sensitivity and specificity of ,50 repeats was 79% and 96%, respectively (Wieben et al., PloS ONE, 2012). The purpose of this present study was to evaluate the TNR expansion in a larger cohort of Caucasian FECD patients. Methods : We recruited 387 FECD patients (158 males and 229 females; mean age: 69.7±9.2 years; range: 32-92 years) who were scheduled to receive Descemets membrane endothelial keratoplasty (DMEK) at the University of Erlangen-Nürnberg Hospital in order to obtain peripheral blood samples. All patients were diagnosed as FECD due to symptoms such as guttae, corneal edema, and decrease of corneal endothelial cell density. Purification of genomic DNA from each patients blood sample was ...
Purpose : Fuchs Endothelial Corneal Dystrophy (FECD) is a late-onset oxidative stress-induced disease characterized by progressive loss of corneal endothelial cells. We previously reported increased mitochondrial fragmentation as a possible phenomenon that explained the pathomechanism of FECD. The aim of this study is to further decipher the key checkpoints involved in mitochondrial quality control that may be aberrantly regulated in FECD. Methods : Tissue lysates prepared from post-keratoplasty specimens from late-onset FECD cases were compared with age-matched normal donor specimens (n=3 for each group) for PINK1, phosphoParkin(Ser65), phospho-Drp1(Ser616), phosphoDrp1(Ser637). Whole cell lysates of human corneal endothelial cell line immortalized with hTert (HCEnC-21T) were treated with 50mM menadione (MN) and 10nM Bafilomycin A1 for 20 hours. HCEnC-21T cells were transfected with YFP-Parkin, fragmentation was induced with 50mM MN, and mitochondria were visualized with immunofluorescence ...
Fuchs endothelial corneal dystrophy (FECD) MIM#136800 and posterior polymorphous corneal dystrophy (PPCD) MIM#122000 both belong to the corneal endothelial dystrophies in which endothelial dysfunction can lead to corneal oedema. In addition, they both share the common features of endothelial metaplasia and the secretion of an abnormal Descemets membrane as a pathological posterior collagenous layer (PCL) with a small or absent posterior non-banded zone.1,2. The exact cause of both FECD and PPCD is still unknown, although both are thought to be the result of a disorder of neural crest terminal differentiation.3 Mutations in COL8A2, the gene for the α2(VIII) chain of type VIII collagen, have previously been described in patients with both FECD and PPCD,4,5 and type ...
Arch Ophthalmol. 2012 Apr;130(4):433-9. doi: 10.1001/archopthalmol.2011.1626. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt
Expertise, Disease and Conditions: Cataract Surgery, Cataracts, Cornea Transplant, Cornea/Anterior Segment Disease, Corneal Disorders, Corneal Dystrophies, Corneal Ulcer, Dry Eyes, Fuchs Dystrophy of the Cornea, Fuchs Endothelial Corneal Dystrophy, Herpes Infections, Keratoconus, Laser Surgery, Ophthalmology, Refractive Surgery, Thyroid Eye Disease, ...
Researchers at Mayo Clinic have identified the specific genetic defect in the TCF4 gene - the expansion of the TGC repeat - that appears to be responsible for Fuchs endothelial corneal dystrophy (FECD).
Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 amino acid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells (adipokine). The protein belongs to the soluble defence collagen superfamily; it has a collagen-like domain structurally homologous with collagen VIII and X and complement factor C1q-like globular domain. Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. The human Adiponectin is expressed in E. coli as a recombinant 25.1 kDa sinle, non-glycosylated polypeptide chain containing 231 amino acid residues ...
RecName: Full=Adenylate cyclase type 8; EC=126.96.36.199;AltName: Full=Adenylate cyclase type VIII;AltName: Full=ATP pyrophosphate-lyase 8;AltName: Full=Adenylyl cyclase 8;AltName: Full=Ca(2+)/calmodulin-activated adenylyl ...
Data scientist Thomas Fuchs develops and applies advanced machine learning and computer vision techniques for tackling large-scale computational pathology challenges in cancer research and clinical practice.
Kerstin Fuchs is the author of this article in the Journal of Visualized Experiments: Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent
PURPOSE: To investigate the functional role that the zinc e-box binding homeobox 1 (ZEB1) gene, which underlies the genetic basis of posterior polymorphous corneal dystrophy 3 (PPCD3), plays in corneal endothelial cell proliferation, apoptosis, migration, and barrier function. METHODS: A human corneal endothelial cell line (HCEnC-21T) was transfected with siRNA targeting ZEB1 mRNA. Cell proliferation, apoptosis, migration, and barrier assays were performed: Cell proliferation was assessed with cell counting using a hemocytometer; cell apoptosis, induced by either ultraviolet C (UVC) radiation or doxorubicin treatment, was quantified by measuring cleaved caspase 3 (cCASP3) protein levels; and cell migration and barrier function were monitored with electric cell-substrate impedance sensing (ECIS ...
Findings published in the American Journal of Pathology offer new directions for treatment of patients with Fuchs Endothelial Corneal Dystrophy (FECD)
Do You Have Corneal Dystrophy, Fuchs Endothelial, 1? Join friendly people sharing true stories in the I Have Corneal Dystrophy, Fuchs Endothelial, 1 group. Find support forums, advice and chat with groups who share this life experience. A Corneal D...
... Article 347 of bionet.software: Path: iuvax!bionet!embl.bitnet!FUCHS >From: [email protected] ("Rainer Fuchs ", EMBL Data Library) Newsgroups: bionet.software Subject: Molecular biological software/EMBL File Server Message-ID ...
Buy Fuchs «Extra» online: this off-dry red wine is very dense and has a fine fruitiness with a touch of sweetness. Histamine content 0.228 mg/l.
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TY - JOUR. T1 - Evaluation of phacoemulsification-induced oxidative stress and damage of cultured human corneal endothelial cells in different solutions using redox fluorometry microscopy. AU - Nishi, Yutaro. AU - Engler, Christoph. AU - Na, Dae Ro. AU - Kashiwabuchi, Renata T.. AU - Shin, Young Joo. AU - Cano, Marisol. AU - Jun, Albert S.. AU - Chuck, Roy S.. PY - 2010/12/1. Y1 - 2010/12/1. N2 - Purpose: To describe the basic concept of redox fluorometry microscopy and investigate its efficacy in evaluating the state of cultured human corneal endothelial cells in different solutions when ultrasonic energy was applied in vitro. Methods: Human corneal endothelial cells from human donor tissue not suitable for transplantation were cultured. A phacoemulsification probe with a 30° round, 1.1- mm TurboSonics® ABS™ Tip (Alcon, Fort Worth, Texas) was introduced into culture dishes filled with balanced salt solution (BSS) and BSS plus (Alcon, Fort Worth, Texas). Cellular autofluorescence images were ...
Trappist Westvleteren 8 (VIII) is a Dubbel style beer brewed by Brouwerij Westvleteren (Sint-Sixtusabdij van Westvleteren) in Westvleteren, Belgium. 4.48 average with 2197 ratings, reviews and opinions.
Trappist Westvleteren 8 (VIII) is a Dubbel style beer brewed by Brouwerij Westvleteren (Sint-Sixtusabdij van Westvleteren) in Westvleteren, Belgium. 4.48 average with 2198 ratings, reviews and opinions.
Alport syndrome (AS) is characterized by renal, cochlear, and ocular involvement. In the absence of treatment, renal disease progresses from microscopic hematuria to proteinuria, progressive renal insufficiency, and end-stage renal disease (ESRD) in all males with X-linked (XL) AS, and in all males and females with autosomal recessive (AR) AS. Progressive sensorineural hearing loss (SNHL) is usually present by late childhood or early adolescence. Ocular findings include anterior lenticonus (which is virtually pathognomonic), maculopathy (whitish or yellowish flecks or granulations in the perimacular region), corneal endothelial vesicles (posterior polymorphous dystrophy), and recurrent corneal erosion. In individuals with autosomal dominant (AD) AS, ESRD is frequently delayed until later adulthood, SNHL is also relatively late in onset and ocular involvement is rare. Thin basement membrane nephropathy (TBMN) is characterized by persistent microscopic hematuria often first observed in childhood; ...
Visual system homeobox 1 is a protein that in humans is encoded by the VSX1 gene. The protein encoded by this gene contains a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior polymorphous corneal dystrophy (PPCD) and keratoconus. Two transcript variants encoding different isoforms have been found for this gene. GRCh38: Ensembl release 89: ENSG00000100987 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000033080 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". Semina EV, Mintz-Hittner HA, Murray JC (Apr 2000). "Isolation and characterization of a novel human paired-like homeodomain-containing transcription factor gene, VSX1, expressed in ocular tissues". Genomics. 63 (2): 289-93. doi:10.1006/geno.1999.6093. PMID 10673340. "Entrez Gene: VSX1 visual system homeobox ...
Your cornea is the clear part of the front of the eye. Corneal dystrophies are common genetic conditions which cause changes to your cornea without any inflammation, infection or other eye disease. Corneal dystrophies affect the clearness of your cornea and usually involve both eyes. Although they can often get worse over time, normally this happens very slowly. Many corneal dystrophies develop so slowly that they may never get to a point where they affect your vision.
Corneal dystrophy comes in more than 20 types and occurs when material piles up in at least one of the five layers of the cornea. Corneal dystrophy can cause the cornea to lose its clarity, with the...
Pepperl+Fuchs is a pioneer and innovator of industrial sensors for factory automation and an expert for explosion protection in process automation
GAINESVILLE Wednesday evening, hazy rumors of an impending Neo-Nazi march reached some wary protesters. A few quickly rallied to denounce the marchers in downtown Gainesville, only to find plazas e
Daniela Zühlke, Kirsten Dörries, Jörg Bernhardt, Sandra Maaß, Jan Muntel, Volkmar Liebscher, Jan Pané-Farré, Katharina Riedel, Michael Lalk, Uwe Völker, Susanne Engelmann, Dörte Becher, Stephan Fuchs, Michael Hecker ...
This Histri was built automatically but not manually verified. As a consequence, the Histri can be incomplete or can contain errors ...
Fuchs Dystrophy is a type of corneal disease that affects the inner most layer of the cornea-the endothelium. Fuchs Dystrophy is slowly progressive, is found in both eyes and is slightly more common in women than men. While we can see Fuchs Dystrophy in people in their 30s and 40s, it usually does not compromise vision until people are in their 50s or 60s.. About Fuchs Dystrophy. The endothelial cells are responsible for pumping water out of the cornea and helping to maintain the corneal transparency. While the reason is poorly understood, in Fuchs Dystrophy, the endothelial cells die, which make the endothelium less efficient in its pumping activity. This results in the cornea swelling and distorting vision. Fuchs Dystrophy Risks & Severity. Researchers reporting in the journal Investigative Ophthalmology and Visual Science studied the effects of smoking, and other risk factors, on the development of advanced Fuchs endothelial corneal dystrophy (FECD) and on central corneal thickness ...
Looking for information on Dog Corneal Dystrophy (Corneal Opacities) in Manchester? We have compiled a list of businesses and services around Manchester that should help you with your search. We hope this page helps you find information on Dog Corneal Dystrophy (Corneal Opacities) in Manchester.
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PURPOSE: To report the presence of the R124H mutation in two Spanish families with Avellino corneal dystrophy (ACD). METHODS: Two families with subjects who presented biomicroscopic features of ACD were included in this study. They have no relatives
Pharmacist Ben Fuchs radio show archives. Ben Fuchs archive is a directory of all the Bright Side Ben radio show broadcasts produced by the Genesis Communications Network - GCN, Youngevity and DR Joel Wallach
Pharmacist Ben Fuchs radio show archives. Ben Fuchs archive is a directory of all the Bright Side Ben radio show broadcasts produced by the Genesis Communications Network - GCN, Youngevity and DR Joel Wallach
If you are 70½ years old or older, you can make a tax free donation via your IRA to youir favorite charity Read More. Covered California Current members can renew or change their health plans until Jan. 31, 2018. Coverage now will start March 1, 2018. All other states are now closed. Please copy and paste to circulate.. ...
Machado Y., R. Freier, S. Scheiblhofer, T. Thalhamer, M. Mayr, P. Briza, S. Grutsch, L. Ahammer, J. E. Fuchs, H. G. Wallnoefer, A. Isakovic, V. Kohlbauer, A. Hinterholzer, M. Steiner, M. Danzer, J. Horejs-Hoeck, F. Ferreira, K. R. Liedl, M. Tollinger, P. Lackner, C. M. Johnson, H. Brandstetter, J. Thalhamer and R. ...
Study VIII - Environmental and Nutritional Diseases flashcards from Vanessa Almaden's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
Study VIII - Environmental and Nutritional Diseases flashcards from Valerie Queyquep's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
Unusual giant nodules on the posterior surface of Descemets membrane were observed in two out of over 400 corneae examined during routine histopathological reporting. Both of the patients, a 60-year-old man and a 26-year-old woman, had histories of corneal trauma. Neither was associated with chronic keratitis or corneal dystrophy. Light microscopy showed these nodules to be composed of material resembling Descemets membrane. Histochemical and electron microscopical preparations identified oxytalan fibres within the outer layers of the nodules. These fibres are not a feature of the normal adult Descemets membrane. The findings are discussed and compared with other nodular lesions of Descemets membrane. ...
Baburajeev, C. P. and Mohan, C. D. and Shobith, R. and Mason, Daniel J. and Fuchs, Julian E. and Bender, Andreas and Barash, Uri and Vlodavsky, Israel and Rangappa, K. S. (2017) Identification of novel class of triazolo-thiadiazoles as potent inhibitors of human heparanase and their anticancer activity. BMC Cancer, 17 (1). pp. 1-14. ISSN 1471-2407 Anusha Sebastian, and Pandey, Vijay and Mohan, C. D. and Chia, Yi Ting and Shobith, R. and Mathai, Jessin and Baburajeev, C. P. and Paricharak, Shardul and Mervin, Lewis H. and Bulusu, Krishna C. and Fuchs, Julian E. and Bender, Andreas and Yamada, Shuhei and Basappa, and Lobie, Peter E. and Rangappa, K. S. (2016) Novel adamantanyl-based thiadiazolyl pyrazoles targeting EGFR in triple-negative Breast Cancer. ACS Omega, 1 (6). pp. 1412-1424. ISSN 2470-1343 Gowtham, S. and Babu Rajeev, C. P. and Mohan, C. D. and Sinha, Ameya and Chu, Trang T. T. and Sebastian Anusha, and Ximei, Huang and Fuchs, Julian E. and Bender, Andreas and Rangappa, K. S. and ...
Mutations in human and/or mouse homologs are associated with this disease. Synonyms: FCD; Francois-Neetens speckled corneal dystrophy
Gabriel Fuchs is a senior consultant and business intelligence expert. His column Reality IT takes an ironic look at what real-world IT solutions often look like - for better or for worse. The ideas and thoughts expressed in this column are based on Fuchs own personal experience and imagination and do not reflect the situation at any particular company. His book, Dealing with Nasty Colleagues: The Art of Winning in Office Politics While Still Getting the Job Done, can be ordered at www.amazon.co.uk. He can be reached at [email protected]
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Schematic of proposed mechanism of TGFBI-related corneal dystrophies in present study. The hypothesis of pathogenesis of TGFBI-related corneal dystrophies mainl
The scenario that the Gemara describes in Berachos 21a discusses the halacha when one is in the middle of davening Shemoneh Esrei and realizes that he had already davened this tefillah. The Gemara says that he should stop davening immediately, even if he is in the middle of a berachah. Even though one may daven a tefillas nedavah (a voluntary tefillah) whenever he desires, he must stop in the middle since he initially began davening under the impression that the tefillah was obligatory. The Tosafos Harash explains that just as there are no korbanos that are part obligatory and part voluntary, so too there cannot be a tefillah that is part obligatory and part voluntary.. Based on this, the Rambam (Hilchos Tefillah 10:6) wrote a tremendous chiddush. He wrote that the abovementioned Gemara - that discusses the halacha concerning ones realization in the middle of Shemoneh Esrei that he has already davened that tefillah - should not apply when the tefillah that one is in the midst of reciting is ...
Global Specialty Lubricants market report 2018 provides analysis based on vendors, types, applications and presents upcoming industry trends.
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For COM.POST #15 Raymond Dijkstra curated an exclusive live program with new acoustic compositions to be made on the spot in a blind date setting. With public reader Frédérique Bruyas (fr), composer of acoustic and visual happenings Limpe Fuchs (de) , soundartist Timo van Luijk/Af Ursin (fin/be) & Edward Ka-spel (uk/nl) who is known from The Legendary Pink Dots o=Raymond
Université de Liège - ULg , Département de langues et littératures romanes , Langues et littératures espagnoles et hispano-américaines ,] ...
concretis entravessarem rasclats desfrunzeixes desemmandrís paleoplacer caseïficat infringien torcejam regulem trempant desrengués moltonegí [email protected]íemo.org ...
MalaCards based summary : Corneal Dystrophy, Thiel-Behnke Type, also known as thiel-behnke corneal dystrophy, is related to corneal dystrophy, avellino type and epithelial basement membrane dystrophy, and has symptoms including photophobia, corneal dystrophy and corneal scarring. An important gene associated with Corneal Dystrophy, Thiel-Behnke Type is TGFBI (Transforming Growth Factor Beta Induced). Affiliated tissues include eye, and related phenotypes are Increased cilium length after serum starvation and vision/eye ...
MENLO PARK, Calif., May 6, 2016 /CNW/ -- Avellino Labs Commences Cross-Sectional Study of the Prevalence of TGFBI Corneal Dystrophies in a North American Population.
Definition of central crystalline corneal dystrophy of Snyder. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions.
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Fuchs, A., Wiese, B., Altiner, A., Wollny, A. and Pentzek, M. (2012), Cued Recall and Other Cognitive Tasks to Facilitate Dementia Recognition in Primary Care. Journal of the American Geriatrics Society, 60: 130-135. doi: 10.1111/j.1532-5415.2011.03765.x ...
Mesin yang digunakan dalam produksi semen mendapatkan beban yang besar. Selain getaran yang kuat saat menghancurkan dan menggiling batuan berat, suhu tungku yang ekstrem menuntut performa yang besar pada peralatan - serta pada pelumasannya. Bersama dengan produsen roda gigi dan mesin, FUCHS LUBRITECH mengembangkan pelumas khusus yang inovatif untuk penghancur, penggiling, tanur putar atau roller press. Untuk melakukan ini, kami berusaha mencari solusi khusus aplikasi yang akan membantu melindungi suku cadang mesin secara efektif dari aus, meningkatkan interval perawatan - serta memperpanjang umur peralatan Anda. ...
While officials in the executive branch, members of Congress and senior congressional staffers spin in and out of the private and public sectors, so too does privilege, power, access and, of course, money.
The general counsel of the Consumer Financial Protection Bureau is a keynote speaker at the upcoming Women Influence & Power in Law Conference in Washington D.C.
Quiet session this month, possibly because of it being busy with the recent ARVO meeting, the ECVO meeting, and the upcoming RCOphth Congress. Still, we chatted about a fair range of eye pathology topics yesterday, from rare corneal dystrophies to ocular trauma to the value of deeper sections. Here are a few of the cases…
Dörte Becher, Kristina Hempel, Susanne Sievers, Daniela Zühlke, Jan Pané-Farré, Andreas Otto, Stephan Fuchs, Dirk Albrecht, Jörg Bernhardt, Susanne Engelmann, Uwe Völker, Jan Maarten van Dijl, Michael Hecker ...
Congenital stromal corneal dystrophy (CSCD), also called Witschel dystrophy, is an extremely rare, autosomal dominant form of corneal dystrophy. Only 4 families have been reported to have the disease by 2009. The main features of the disease are numerous opaque flaky or feathery areas of clouding in the stroma that multiply with age and eventually preclude visibility of the endothelium. Strabismus or primary open angle glaucoma was noted in some of the patients. Thickness of the cornea stays the same, Descemets membrane and endothelium are relatively unaffected, but the fibrills of collagen that constitute stromal lamellae are reduced in diameter and lamellae themselves are packed significantly more tightly. CSCD is associated with a mutation in the gene DCN that encodes the protein decorin, located at chromosome 12q22. The disorder is inherited in an autosomal dominant manner, which indicates that the defective gene responsible for a disorder is located on an autosome (chromosome 12 is an ...
Fuchs corneal endothelial dystrophy is an inherited eye condition, which may cause your cornea to become cloudy.Fuchs dystrophy develops slowly and can affect people to a varying degree. While some people may never have any real problems with their vision, others can require a corneal treatment quite early in life.
Schnyder crystalline corneal dystrophy (SCCD, MIM 121800) is a rare autosomal dominant disease characterized by progressive opacification of the cornea resulting from the local accumulation of lipids, and associated in some cases with systemic dyslip
Fuchsia und Fuchs Photo & image by Rosa Lieblich ᐅ View and rate this photo free at fotocommunity.de. Discover more images here.
Diagnosis Code 371.50 information, including descriptions, synonyms, code edits, ICD-10 conversion and references to the diseases index.
Looking for CN VIII? Find out information about CN VIII. auditory nerve in man, the eighth pair of cranial nerves.The nerve copsists of two functional parts- the vestibular, which is the conductor of the impulses... Explanation of CN VIII
The recycling industry is responsible for collecting processing and marketing billions of dollars worth of metals, paper, plastics and other recovered materials. Through Recycling Today and Recycling Today Global Edition , market directories, and industry conferences, GIE serves the scrap and recycling industry in North America and globally.
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col3negoriginal, col3negoriginal.com, col3, col3neg, col 3 neg original col3negoriginal. A place to watch and share Sri Lankan videos.
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Disclaimer: Wordsmith.org is not responsible for views expressed on this site. Use of this forum is at your own risk and liability - you agree to hold Wordsmith.org and its associates harmless as a condition of using it ...
Disclaimer: Wordsmith.org is not responsible for views expressed on this site. Use of this forum is at your own risk and liability - you agree to hold Wordsmith.org and its associates harmless as a condition of using it ...
Liu B, Weinzimer SA, Gibson TB, Mascarenhas D, Cohen P (2003). "Type Ialpha collagen is an IGFBP-3 binding protein". Growth ... Functional interactions with the EGF receptor and the type I/type II TGFβ receptor system have also been reported, and other ... IGFBP-3 exerts antiproliferative effects in many cell types by blocking the ability of IGF-1 and IGF-2 to activate the IGF1R ( ... Xue A, Scarlett CJ, Jackson CJ, Allen BJ, Smith RC (2008). "Prognostic significance of growth factors and the urokinase-type ...
It has been reported that biglycan interacts more strongly with collagen type II than collagen type I. Biglycan has been ... Pogány G, Hernandez DJ, Vogel KG (August 1994). "The in vitro interaction of proteoglycans with type I collagen is modulated by ... "Binding of the proteoglycan decorin to collagen type VI". J. Biol. Chem. 267 (8): 5250-6. PMID 1544908. Bowe MA, Mendis DB, ... "Interaction of biglycan with type I collagen". J. Biol. Chem. 270 (6): 2776-83. doi:10.1074/jbc.270.6.2776. PMID 7852349. ...
Type II collagen can help distinguish it from other tumors. Mesenchyme sarcoma Hoang MP, Suarez PA, Donner LR, et al. (October ... 1 (6). Müller S, Söder S, Oliveira AM, Inwards CY, Aigner T (August 2005). "Type II collagen as specific marker for mesenchymal ... 8 (4): 291-301. doi:10.1177/106689690000800408. PMID 11494006. Chen JY, Hsu SS, Ho JT (May 2004). "Extraskeletal intracranial ...
Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). A closely related family member is the ... gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen ... Vogel W, Gish GD, Alves F, Pawson T (Dec 1997). "The discoidin domain receptor tyrosine kinases are activated by collagen". ... Mohan RR, Mohan RR, Wilson SE (Jan 2001). "Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase ...
Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ... The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen ... 1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI". Exp ... 1996). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 ...
Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ... integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. 276 (31): 29368-74. doi:10.1074/jbc. ... They are found on a wide variety of cell types including, T cells (the NKT cells), NK cells, fibroblasts and platelets. ... Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells. DX5 is a monoclonal ...
Collagen is exposed at the site of injury, the collagen promotes platelets to adhere to the injury site. Platelets release ... TypesEdit. Hemostasis can be achieved in various other ways if the body cannot do it naturally (or needs help) during surgery ... Some main types of hemostasis used in emergency medicine include: *Chemical/topical- This is a topical agent often used in ... Which hemostasis type used is determined based on the situation.. Developmental Haemostasis refers to the differences in the ...
... with type IV collagen. J Biol Chem 1990; 265:17281-4. Paralkar VM, Vukicevic S, Reddi AH. Transforming growth factor beta type ... Transitions in collagen types during matrix-induced cartilage, bone, and bone marrow formation. Proc Natl Acad Sci U S A 1977; ... potentiation and binding to type IV collagen. J Cell Biol 1992; 119:1721-8. Ripamonti U, Ma S, Cunningham NS, Yeates L, Reddi ... Ramachandran, G.N., Reddi, A.H. (Eds.), Biochemistry of Collagen. Plenum Press, New York, NY, 1976. Piez, K.A., Reddi, A.H. ( ...
Each type of connective tissue in animals has a type of ECM: collagen fibers and bone mineral comprise the ECM of bone tissue; ... Facit (Type IX, XII, XIV). *Short chain (Type VIII, X). *Basement membrane (Type IV) ... Collagen. Collagens are the most abundant protein in the ECM. In fact, collagen is the most abundant protein in the human ... The collagen can be divided into several families according to the types of structure they form: *Fibrillar (Type I, II, III, V ...
Assouti M, Vynios DH, Anagnostides ST, Papadopoulos G, Georgakopoulos CD, Gartaganis SP (Jan 2006). "Collagen type IX and HNK-1 ... 7 (4): 353-8. doi:10.1101/gr.7.4.353. PMC 139146 . PMID 9110174. Tone Y, Kitagawa H, Imiya K, Oka S, Kawasaki T, Sugahara K ( ... 10 (5): 1443-8. doi:10.3892/or.10.5.1443. PMID 12883721. Kakuda S, Shiba T, Ishiguro M, Tagawa H, Oka S, Kajihara Y, Kawasaki T ... 8 (7): 654-63. doi:10.1038/sj.mp.4001382. PMID 12874601. Chochi K, Ichikura T, Majima T, Kawabata T, Matsumoto A, Sugasawa H, ...
Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to ... is a collagen cleaving enzyme which is present in the connective tissue of most mammals. In humans, the MMP-8 protein is ... 77 (12): 2731-8. PMID 1646048. Bläser J, Knäuper V, Osthues A, et al. (1992). "Mercurial activation of human polymorphonuclear ... 371 (8): 733. doi:10.1515/bchm3.1990.371.2.733. PMID 2169766. Mallya SK, Mookhtiar KA, Gao Y, et al. (1991). "Characterization ...
In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I ... "Tumor Necrosis Factor Alpha Inhibits Type I Collagen Synthesis through Repressive CCAAT/Enhancer-Binding Proteins". Mol. Cell. ... CEBP-beta is critical for normal macrophage functioning, an important immune cell sub-type; mice unable to express CEBP-beta ... 20 (3): 912-8. doi:10.1128/MCB.20.3.912-918.2000. PMC 85208 . PMID 10629048. Tanaka T, Uchiumi T, Hinoshita E, Inokuchi A, Toh ...
It is composed of different kinds of collagen (Type IV and VIII) than the stroma. The endothelial layer is located at the ... "Tissue Distribution of Type VIII Collagen in Human Adult and Fetal Eyes" (PDF). Investigative Ophthalmology and Visual Science ... Its thickness ranges from 3 μm at birth to 8-10 μm in adults. The corneal endothelium is a single layer of squamous cells ...
Immunohistochemical staining of basement membranes of kidney for laminin, collagen type IV, fibronectin, and Goodpasture ... "Regulation of collagen type IV genes is organ-specific: Evidence from a canine model of Alport syndrome". Kidney International ... X-linked hereditary nephritis resulting from a single base mutation in the gene encoding the alpha 5 chain of collagen type IV ... 42 (5): 235-8. doi:10.1111/j.1748-5827.2001.tb02027.x. PMID 11380016. Zheng, Keqin; Perry, Julie; Harvey, Scott J; Sado, ...
... and types I and III collagen". J. Biol. Chem. 277 (13): 10783-8. doi:10.1074/jbc.M110992200. PMID 11788595. Dokras A, Gardner ... Biliran H, Sheng S (2002). "Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous ... 297 (1): 125-8. doi:10.1016/S0006-291X(02)02136-8. PMID 12220518. Sood AK, Fletcher MS, Gruman LM, et al. (2002). "The ... 8 (9): 2924-32. PMID 12231537. Son HJ, Sohn TS, Song SY, et al. (2003). "Maspin expression in human gastric adenocarcinoma". ...
Type VIII. OI caused by mutation in the gene LEPRE1 is classified as type VIII. ... Type III. Collagen improperly formed, enough collagen is made but it is defective. ... There are eight types, with type I being the least severe and type II the most severe. Diagnosis is often based on symptoms ... Similar to Type I, Type IV can be further subclassified into types IVA and IVB characterized by absence (IVA) or presence (IVB ...
"Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression ... "Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens". BMC Genomics. 13: 306. ... untranslated region of KRAS gene predicts response in wild-type KRAS patients with metastatic colorectal cancer treated with ... 42 (8): 1330-3. doi:10.1016/j.biocel.2009.02.023. PMID 20619222. Lee ST, Chu K, Oh HJ, Im WS, Lim JY, Kim SK, Park CK, Jung KH ...
... show homology with the alpha chains of fibronectin and vitronectin receptors and collagen type IV". J. Leukoc. Biol. 51 (6): ... CD93 is a C-type lectin transmembrane receptor which plays a role not only in cell-cell adhesion processes but also in host ... All of them contain a C-type lectin domain, a series of epidermal growth factor like domains, a highly glycosylated mucin-like ... CD93 belongs to the Group XIV C-Type lectin family, a group containing two other members, endosialin (CD248) and thrombomodulin ...
Synthesis of Type IV and Type VI Collagen during Nurse Cell Formation". Experimental Parasitology. 86 (3): 191-199. doi:10.1006 ... 14 (8): 318-323. doi:10.1016/S0169-4758(98)01287-3. ISSN 0169-4758. PMID 17040798. Capó, Virginia A.; Despommier, Dickson D.; ... doi:10.1016/0169-4758(90)90355-8. ISSN 0169-4758. Despommier, Dickson D.; Gold, Allen M.; Buck, Stephen W.; Capo, Virginia; ... ISBN 0-387-94223-8. Despommier, Dickson D.; Gwadz, Robert; Hotez, Peter; Knirsch, Charles (2000). Parasitic Diseases 4th ed. ...
Unlike EC 188.8.131.52, interstitial collagenase, this enzyme cleaves type III collagen more slowly than type I This enzyme belongs ... Collagenase Hasty, K. (1987). "A., Jeffrey, J. J., Hibbs, M. S. and Welgus, H. G. The collagen substrate specificity of human ... This enzyme catalyses the following chemical reaction Cleavage of interstitial collagens in the triple helical domain. ... Neutrophil collagenase (EC 184.108.40.206, matrix metalloproteinase 8, PMNL collagenase, MMP-8) is an enzyme. ...
... collagen type I, and that it interacts with the "d" and "e" bands of fibrils of this collagen. Decorin appears to influence ... This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. ... Decorin has been shown to interact with: Collagen type I Epidermal growth factor receptor and TGF beta 1, TLR2, and TLR4. ... "Decorin core protein fragment Leu155-Val260 interacts with TGF-beta but does not compete for decorin binding to type I collagen ...
"Decorin core protein fragment Leu155-Val260 interacts with TGF-beta but does not compete for decorin binding to type I collagen ... Ebner R, Chen RH, Lawler S, Zioncheck T, Derynck R (November 1993). "Determination of type I receptor specificity by the type ... However, as with other cell types, TGF-β1 can also have the opposite effect on cells of myeloid origin. For example, TGF-β1 ... TGF-β1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or ...
"Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix ... S1PR1 is also involved in other types of cancer: fibrosarcoma cells migrate upon activation of S1PR1 by S1P via RAC1-CDC42 ... Nyalendo C, Michaud M, Beaulieu E, Roghi C, Murphy G, Gingras D, Béliveau R (May 2007). "membrane type I matrix ... 114 (8): 1082-9. doi:10.1172/JCI22716. PMC 522258 . PMID 15489955. Fisher KE, Pop A, Koh W, Anthis NJ, Saunders WB, Davis GE ( ...
The main substrates of the gelatinases are type IV collagen and gelatin, and these enzymes are distinguished by the presence of ... All six membrane-type MMPs (#14, No. 15, #16, No. 17, #24, and #25) have a furin cleavage site in the pro-peptide, which is a ... These collagens are the major components of bone, cartilage and dentin, and MMPs are the only known mammalian enzymes capable ... 14 has also been shown to cleave fibrillar collagen, and there is evidence that No. 2 is capable of collagenolysis. In MeSH, ...
There was a great need for fast tissue-typing techniques and the work was performed in collaboration with the biotechnology ... Differences in monocyte phenotypes induced by cultivation on glass or on collagen". Journal of Experimental Medicine. 156 (4): ... Together with Professor Frode Vartdal, Gaudernack contributed to the development of cell-isolation systems for tissue-typing ... Chiarandini, DJ; Stefani, E (1979). "Electrophysiological identification of two types of fibres in rat extraocular muscles". ...
Several types of catenins work with N-cadherins to play an important role in learning and memory (For full article, see ... Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR (October 2011). "A role for collagen XXIII in cancer cell ... For instance, higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened ... levels of collagen helped facilitate adhesions and anchorage-independent cell growth and provided evidence of collagen XXIII's ...
"Entrez Gene: COL8A1 collagen, type VIII, alpha 1". Shuttleworth CA (1998). "Type VIII collagen". Int. J. Biochem. Cell Biol. 29 ... Illidge C, Kielty C, Shuttleworth A (1998). "The alpha1(VIII) and alpha2(VIII) chains of type VIII collagen can form stable ... This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major ... Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ...
"Entrez Gene: COL8A2 collagen, type VIII, alpha 2". Shuttleworth CA (1998). "Type VIII collagen". Int. J. Biochem. Cell Biol. 29 ... Illidge C, Kielty C, Shuttleworth A (1998). "The alpha1(VIII) and alpha2(VIII) chains of type VIII collagen can form stable ... 1991). "The alpha 2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome 1". ... Greenhill NS, Rüger BM, Hasan Q, Davis PF (2000). "The alpha1(VIII) and alpha2(VIII) collagen chains form two distinct ...
collagen alpha-2(VIII) chain. Names. collagen VIII, alpha-2 polypeptide. collagen, type VIII, alpha 2. endothelial collagen. ... COL8A2 collagen type VIII alpha 2 chain [Homo sapiens] COL8A2 collagen type VIII alpha 2 chain [Homo sapiens]. Gene ID:1296 ... Collagen; Collagen triple helix repeat (20 copies). * NM_005202.3 → NP_005193.1 collagen alpha-2(VIII) chain isoform 1 ... collagen type VIII alpha 2 chainprovided by HGNC. Primary source. HGNC:HGNC:2216 See related. Ensembl:ENSG00000171812 MIM: ...
J:35224 Iruela-Arispe ML, et al., Expression of type VIII collagen during morphogenesis of the chicken and mouse heart. Dev ... Blue cells = expressed in wild-type.. Gray triangles = other expression annotations only. (e.g. absence of expression or data ...
VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to ... A collagen heterotrimer containing type VIII alpha chains; [alpha1( ... Collagen type VIII expression in human diabetic nephropathy. * Efficient Generation of Human Embryonic Stem Cell-Derived ... Maternal exposure to carbon black nanoparticle increases collagen type VIII expression in the kidney… ...
Collagen degradation (Homo sapiens) * Collagen type VIII degradation by ELANE (Homo sapiens) * Collagen type VIII fibril [ ... Collagen type VIII degradation by MMP1 (Homo sapiens) * Collagen type VIII fibril [extracellular region] (Homo sapiens) ... Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Homo sapiens) * Collagen type VIII fibril [extracellular ... Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Homo sapiens) * Collagen type VIII fibril [extracellular ...
Aubrey Organics, Body Lotion, Collagen & Almond, All Skin Types, 8 fl oz (237 ml) 93 Reviews ... Aubrey Organics, Body Lotion, Collagen & Almond, All Skin Types, 8 fl oz (237 ml). By. Aubrey Organics. ... Aubrey Organics, Body Lotion, Collagen & Almond, All Skin Types, 8 fl oz (237 ml). By. Aubrey Organics. ... Aubrey Organics, Body Lotion, Collagen & Almond, All Skin Types, 8 fl oz (237 ml). By Aubrey Organics ...
VIII) chain of type VIII collagen, have previously been described in patients with both FECD and PPCD,4,5 and type … ... Exclusion of COL8A1, the gene encoding the α2(VIII) chain of type VIII collagen, as a candidate for Fuchs endothelial dystrophy ... Exclusion of COL8A1, the gene encoding the α2(VIII) chain of type VIII collagen, as a candidate for Fuchs endothelial dystrophy ...
Efficacy and Safety of Riboflavin-Ultraviolet Type A Rays Inducing Cross-Linking of Corneal Collagen in Patients Aged 8 to 16 ... Efficacy and Safety of Riboflavin-Ultraviolet Type A Rays Inducing Cross-Linking of Corneal Collagen in Patients Aged 8 to 16 ... Efficacy and Safety of Riboflavin-Ultraviolet Type A Rays Inducing Cross-Linking of Corneal Collagen in Patients Aged 8 to 16 ... Purpose : To assess the effectiveness and safety of riboflavin-ultraviolet type A (UVA) rays induced cross-linking (CXL) of ...
These studies indicate that the dye and light treatment of insoluble Type I collagen (1) results in cross-linking of collagen ... Insoluble Type I collagen from bovine Achilles tendon (Sigma C9879) was suspended in a 3 mM solution of the dye diEd66Br ... Gel electrophoretic studies of photochemical cross-linking of type I collagen with brominated 1,8-naphthalimide dyes and ... Following pelleting of the collagen by centrifugation and 3x washing in phosphate-buffered saline, aliquots of light-treated ...
Anti-type II collagen antibodies, anti-CCP, IgA RF and IgM RF are associated with joint damage, assessed eight years after ... Background: Early appearance of antibodies specific for native human type II collagen (anti-CII) characterizes an ... Keywords: Arthritis, Juvenile Idiopathic Arthritis, Anti-CCP, Rheumatoid factor, Anti-collagen type II antibodies, ... assessed after eight years of disease. The role of anti-CII in JIA should be further studied. ...
Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 Stable Identifier ... Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Bos taurus) ... Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Bos taurus) ... Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens) ...
The collagen fiber network was developed in a representative volume element, which used the inter-fiber spacing to regulate the ... In this work, the role of crosslinks in terms of density and stiffness on the macroscopic behavior of collagen gel were ... Results suggest that the cross-linked fiber alignment dominated the strain stiffening effect of the collagen gel. In addition, ... This work could enhance our understanding of collagen gel mechanics and shed lights on designing future clinical relevant ...
Collagen Type VIII Alpha 2 Chain, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - ... COL8A2 (Collagen Type VIII Alpha 2 Chain) is a Protein Coding gene. Diseases associated with COL8A2 include Corneal Dystrophy, ... This gene encodes the alpha 2 chain of type VIII collagen. This protein is a major component of the basement membrane of the ... Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial ...
colocalizes_with collagen-containing extracellular matrix ISS Inferred from Sequence or Structural Similarity. more info ... a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8. ... Gene type. protein coding. RefSeq status. REVIEWED. Organism. Homo sapiens Lineage. Eukaryota; Metazoa; Chordata; Craniata; ... TSP1; Thrombospondin type 1 repeats. cd04273. Location:219 → 426. ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like ...
Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. Here the D is approximately 67 nm and ... These form the most abundant collagens in vertebrates. ... There are 29 genetically distinct collagens present in animal ... VIII. some endothelial cells. COL8A1, COL8A2. Posterior polymorphous corneal dystrophy 2. IX. FACIT collagen, cartilage, assoc ... Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen ...
... and type IV collagen (tissue framework; brown) showed that the number of OX62+BrdU+ cells increased significantly in the spleen ...
The extracellular matrix of the membranes contained collagen types I, III, IV, and V; fibronectin; laminin; mucopolysaccharide ... Primary antisera to c-retinaldehyde-binding protein; leukocyte common antigen; factor VIII-related antigen; S-100 protein; ... Publication type, MeSH terms, Substances. Publication type. *Research Support, Non-U.S. Govt ... collagen types I, II, III, IV, and V; laminin; and fibronectin were used for immunohistochemical characterization of the ...
The purified mass is dried to provide the desired Type I collagen product which may be ground into a powder or formed into a ... The enzyme-treated comminuted material which is rich in collagen is dispersed in an organic acid to cause the fibrillar mass to ... source such as poultry feet that incorporates a fibrillar mass of connective tissue as well as bony tissue to yield a collagen ... collagen matrix or sponge, depending on the end use therefor. ... A process for extracting type I collagen from an avian ...
Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II ... Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol Rev 1990; 118: 193-232.. Direct Link: ... Analysis of type I and IV collagens by FT-IR spectroscopy and imaging for a molecular investigation of skeletal muscle ... Antibodies to type II collagen in early rheumatoid arthritis: correlation with disease progression. Arthritis Rheum 1996; 39: ...
Distribution of type VIII collagen in tissues: an immunohistochemical study. Connect Tissue Res 1990; 24: 303-318.. *CrossRef, ... Type VIII collagen. Int J Biochem Cell Biol 1997; 29: 1145-1148.. *CrossRef, ... The interaction of decorin core protein fragments with type I collagen. Biochem Biophys Res Commun 1992; 189: 165-172.. * ... Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol Prog 1991; 7: 237-245.. ...
The type IV collagen genes col4a6 and col4a5 are located in this region. The numbers of recombinations in the mutant genomes ... Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish.. ... Type IV Collagen Controls the Axogenesis of Cerebellar Granule Cells by Regulating Basement Membrane Integrity in Zebrafish ... Type IV collagen gene col4a6 is required for axogenesis of the GCs in caudolateral lobes. ...
This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha ... Collagen, type VII, alpha 1 has been shown to interact with Laminin 5 and Fibronectin. Collagen GRCh38: Ensembl release 89: ... of type VII collagen is amino-terminal and chimeric. Homology to cartilage matrix protein, the type III domains of fibronectin ... "Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin". The ...
Media was collected after 24 h treatment of Ang II (100 nM). (C) Real-time PCR results of fibronectin and collagen type I after ... Publication type, MeSH terms, Substances, Grant support. Publication type. *Research Support, Non-U.S. Govt ... B) Measurement of fibronectin and collagen type I in culture media by Western blotting. ... C) Western blot analysis of VSMCs transfected with myc-tagged wild type Rac1 (Rac1-WT) or constitutively active Rac1 (Rac1-V12 ...
ChemProteinCartilageBindsMoleculesLamininCDNATissuesMutationsShort chain collagenFibersChains2000VitroMembranesElastinMoleculeXVIIBasementTriple helicalAlphaBovineChromosome1996ProteoglycansEpithelialChondroitin SulfateIntegrinProcollagenBoneBiosynthesisForm of collagenReceptor for collagenAutosomal dominantDecorin1998ProliferationMolecularChondrocytesExtracellular matrix componentsChainStructuralFibrillar collagensPeptidesInterstitial
- This protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. (nih.gov)
- Electrophoretic protein migration in 8% to 25% gradient polyacrylamide gels following SDS solubilization disclosed numerous, densely packed, essentially contiguous protein bands. (spie.org)
- In the skin, the type VII collagen protein is synthesized by keratinocytes and dermal fibroblasts. (wikipedia.org)
- Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. (nih.gov)
- Undernatured Type II Collagen is the principal structural protein in cartilage that is responsible for its tensile strength and toughness. (iherb.com)
- p>This indicates the type of evidence that supports the existence of the protein. (uniprot.org)
- Collagen / ˈ k ɒ l ə dʒ ɪ n / is the main structural protein in the extracellular space in the various connective tissues in animal bodies. (wikipedia.org)
- We determined concentrations of PICP, ICTP, C-reactive protein (CRP), IL-6, IL-8, and tumor necrosis factor (TNF)-α by using enzyme-linked immunosorbent assay methods. (dovepress.com)
- Of the 28 different types of collagen that have been identified, type II collagen is the main structural protein in cartilage. (nutraingredients.com)
- The role of collagen as a cell signaling protein has been dissected using THPs that represent ligands for specific receptors. (rsc.org)
- Collagen XVII, previously called BP180, is a transmembrane protein which plays a critical role in maintaining the linkage between the intracellular and the extracellular structural elements involved in epidermal adhesion. (wikipedia.org)
- Collagen XVII is a transmembrane protein, like collagen XIII, XXIII and XXV. (wikipedia.org)
- Collagen XVII is a homotrimer of three alpha1(XVII)-chains and a transmembrane protein in type II orientation. (wikipedia.org)
- Unlike most of the collagens, which are secreted into the extracellular matrix, collagen XIII contains a transmembrane domain and the protein has been localized to the plasma membrane. (wikipedia.org)
- Collagen is a protein that strengthens and supports many tissues in the body, including cartilage, bone, tendon, skin and the white part of the eye (sclera). (wikipedia.org)
- When this part of the protein is missing, the structure of type I collagen is compromised. (wikipedia.org)
- This protein is an alpha chain of type VI collagen that aids in microfibril formation. (wikipedia.org)
- As part of type VI collagen, this protein has been implicated in Bethlem myopathy, Ullrich congenital muscular dystrophy (UCMD), and other diseases related to muscle and connective tissue. (wikipedia.org)
- In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. (wikipedia.org)
- Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. (wikipedia.org)
- 100% pure collagen protein that provides building materials for growth and maintenance of a healthy body. (puritan.com)
- She studies the effect of a matrix protein called type VIII collagen on vessel stiffening. (utoronto.ca)
- Fibroblast activation protein α (FAPα) is a cytomembrane protein that is selectively expressed by activated CAFs in various types of human epithelial cancer ( 13 ). (spandidos-publications.com)
- Accordingly, it was demonstrated that protein expression of collagen type IV in human vascular smooth muscle cells is regulated by both SMAD3 protein and TGFβ mediated stimulation of mRNA. (wikipedia.org)
- Biglycan interacts with collagen, both via the core protein and GAG chains. (wikipedia.org)
- This protein heterodimerizes with the beta 1 subunit to form a cell-surface receptor for collagen and laminin. (wikipedia.org)
- The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. (wikipedia.org)
- Collagen receptors are membrane proteins that bind the extracellular matrix protein collagen, the most abundant protein in mammals. (wikipedia.org)
- The mannose receptor is a type I transmembrane protein, with an extracellular N-terminus and an intracellular C-terminus. (wikipedia.org)
- For more information about categorizing protein types, see List of types of proteins. (wikipedia.org)
- Arp2/3 Coronin Dystrophin FtsZ Keratin Myosin Tubulin Collagen Elastin F-spondin Pikachurin Fibronectin Serum Amyloid P Component Serum albumin Complement proteins C1-inhibitor C3-convertase Factor VIII Factor XIII Protein C Protein S Protein Z Protein Z-related protease inhibitor Thrombin Von Willebrand Factor C-reactive protein Hemoglobin (oxyhemoglobin and deoxyhemoglobin) Cadherin Ependymin Integrin NCAM Selectin Ion pumping enzymes are in the enzymes section. (wikipedia.org)
- Collagen /ˈkɒlədʒɪn/ is the main structural protein in the extracellular space in the various connective tissues in animal bodies. (wikipedia.org)
- Heat shock protein 47, also known as SERPINH1 is a serpin which serves as a human chaperone protein for collagen. (wikipedia.org)
- Interactions of heat shock protein 47 with collagen and the stress response: an unconventional chaperone model? (wikipedia.org)
- Two types of fibronectin are present in vertebrates: soluble plasma fibronectin (formerly called "cold-insoluble globulin", or CIg) is a major protein component of blood plasma (300 μg/ml) and is produced in the liver by hepatocytes. (wikipedia.org)
- Tenascin C is a very diverse protein that can produce different functions within the same cell type. (wikipedia.org)
- Kunitz domains are the active domains of proteins that inhibit the function of protein degrading enzymes or, more specifically, domains of Kunitz-type are protease inhibitors. (wikipedia.org)
- Examples of Kunitz-type protease inhibitors are aprotinin (bovine pancreatic trypsin inhibitor, BPTI), Alzheimer's amyloid precursor protein (APP), and tissue factor pathway inhibitor (TFPI). (wikipedia.org)
- These two transcripts contain the same 8 coding exons, and therefore, encode the same protein. (wikipedia.org)
- The C1q protein is produced in collagen-producing cells and shows sequence and structural similarity to collagens VIII and X. It is assumed that the globular ends are the sites for multivalent attachment to the complement fixing sites in immune complexed immunoglobulin. (wikipedia.org)
- As a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family, this protein catalyzes the cis-trans isomerization of proline imidic peptide bonds, which allows it to regulate protein folding of type I collagen. (wikipedia.org)
- In the ER, PPIB interacts with proteins such as P3H1, CRTAP, BiP, GRP94, PDI, and calreticulin to form foldase and chaperone complexes and facilitate protein folding, especially for type I collagen. (wikipedia.org)
- This protein is the major PPIase for type I collagen, since the collagen contains an abundance of prolines that require cis-trans isomerization for proper folding. (wikipedia.org)
- Fibroblast activation protein is a homodimeric integral protein with dipeptidyl peptidase IV (DPPIV)-like fold, featuring an alpha/beta-hydrolase domain and an eight-bladed beta-propeller domain. (wikipedia.org)
- Type II collagen is the main component of cartilage. (news-medical.net)
- ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. (nih.gov)
- Derived from chicken sternum cartilage, UC-II is a patented form of Undernatured (native) Type II Collagen that works with the immune system to support healthy joints. (iherb.com)
- Taken from the chicken's sternum cartilage, UC · II is an innovative, patented form of undenatured type II collagen that works with the immune system to reduce inflammation and restore cartilage (unlike glucosamine & chondroitin, which are materials involved in the structure of healthy cartilage). (prohealth.com)
- not processed by high heat or chemicals) chicken collagen using the chicken's sternum cartilage. (prohealth.com)
- Depending upon the degree of mineralization, collagen tissues may be either rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). (wikipedia.org)
- Cartilage formation, and therefore the expression of type II collagen by chondrocytes, is a critical step in frac-ture healing. (biomedsearch.com)
- Collagen is the main component of connective tissues that make up tendons, ligaments, skin and cartilage. (nutraingredients.com)
- COL1A1 encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. (wikipedia.org)
- Type II collagen, which adds structure and strength to connective tissues, is found primarily in cartilage, the jelly-like substance that fills the eyeball (the vitreous), the inner ear, and the center portion of the discs between the vertebrae in the spine (nucleus pulposus). (wikipedia.org)
- Instead of forming collagen molecules, the abnormal pro-alpha1(II) chains build up in cartilage cells (chondrocytes). (wikipedia.org)
- Type XI collagen is normally found in cartilage as well as the fluid that fills the eyeball, the inner ear, and the center portion of the discs between the vertebrae in the spine (nucleus pulposus). (wikipedia.org)
- Type II collagen is an important component of the eye and mature cartilage tissue. (wikipedia.org)
- Because this type of collagen is an important component of cartilage and other connective tissues, these mutations result in the characteristic signs and symptoms of OSMED. (wikipedia.org)
- Although the nature of the autoantigens in RA is not yet clarified, collagen type II (CII), which is present abundantly in the articular cartilage, the site of inflammatory attack in arthritis, is a potential candidate autoantigen. (royalsocietypublishing.org)
- orally administered 14C hydrolyzed collagen was digested and more than 90% absorbed within 6 hours, with measurable accumulation in cartilage and skin. (wikipedia.org)
- Beneficial action is likely due to hydrolyzed collagen accumulation in the cartilage and stimulated production of collagen by the chondrocytes, the cells of cartilage. (wikipedia.org)
- The content of collagen in cartilage is different between joints and soft tissue structures. (wikipedia.org)
- Collagen supplementation has been shown in research studies (in vitro and in vivo) to increase the thickness or volume of the cartilage tissue. (wikipedia.org)
- Transitions in collagen types during matrix-induced cartilage, bone, and bone marrow formation. (wikipedia.org)
- Other ways of treating velopharyngeal insufficiency is by placing a posterior nasopharyngeal wall implant (commonly cartilage or collagen) or type of soft palate lengthening procedure (i.e. (wikipedia.org)
- Hyaline cartilage matrix is mostly made up of type II collagen and chondroitin sulphate, both of which are also found in elastic cartilage. (wikipedia.org)
- The biochemical breakdown of the articular cartilage results in osteoarthritis, the most common type of joint disease. (wikipedia.org)
- The C-terminus of collagen XVII binds to laminin 5, and correct integration of laminin 5 into the matrix requires collagen XVII. (wikipedia.org)
- Integrin α1β1 binds to collagen via the MIDAS motif in the α subunit I domain. (wikipedia.org)
- It preferentially binds collagens IV, VI and type XIII collagen, but also fibril-forming collagens. (wikipedia.org)
- Integrin α2β1 preferentially binds fibril-forming collagens. (wikipedia.org)
- Integrin α10β1 preferentially binds collagens IV and VI, but also collagen II. (wikipedia.org)
- Integrin α11β1 is expressed by mesenchymal cells in some parts of embryo during its development and also in muscles in adults: it preferably binds fibrillar collagen. (wikipedia.org)
- 2000), include integrin α10β2, which is situated on monocytes and binds type I collagen. (wikipedia.org)
- Receptor activation happens when collagen binds into preformed DDR dimers on cell membrane, when collagen is bound, a conformational change probably occurs, which causes cytosolic kinases to rotate to face each other, and their autophospohorylation. (wikipedia.org)
- It binds fibril-forming collagens and primarily type IV collagen, but also collagen of types I, VI, VIII. (wikipedia.org)
- Binds fibril-forming collagens, collagen of types I, II, III and X. A specific binding site in collagen II has been identified.It is specific for mesenchymal cells. (wikipedia.org)
- Collagens I-IV bind this region with high affinity, while collagen V binds only weakly. (wikipedia.org)
- elements of note are: the D'/D3 domain, which binds to factor VIII (Von Willebrand factor type D domain) the A1 domain, which binds to: platelet GPIb-receptor heparin possibly collagen the A2 domain, which must partially unfold to expose the buried cleavage site for the specific ADAMTS13 protease that inactivates vWF by making much smaller multimers. (wikipedia.org)
- vWF binds to collagen, e.g., when it is exposed in endothelial cells due to damage occurring to the blood vessel. (wikipedia.org)
- It binds collagen and hydroxyapatite in separate domains, is found in relatively large amounts in immature bone, and promotes mineralization of collagen. (wikipedia.org)
- It binds to the same site on the collagen type I molecule as lumican. (wikipedia.org)
- These studies indicate that the dye and light treatment of insoluble Type I collagen (1) results in cross-linking of collagen molecules and (2) does not denature the trimer conformation sufficiently to enable significant digestion by pepsin. (spie.org)
- These defects often cause problems in the biosynthesis of the collagen molecules, their assembly and posttranslational modification process that makes them their final end form of collagen. (news-medical.net)
- Laminins and collagens are molecules of the extracellular matrix which play particularly crucial roles in epithelial development. (stanford.edu)
- Type VIII collagen molecules, expressed by corneal and vascular endothelial cells, are heterotrimers composed of 2 genetically distinct polypeptides, alpha-1(VIII) (COL8A1) and alpha-2(VIII) (COL8A2). (abcam.com)
- Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. (wikipedia.org)
- Fibrillar collagens, such as COL27A1, compose one of the most ancient families of extracellular matrix molecules. (wikipedia.org)
- All of these changes interfere with the formation of mature triple-stranded type II collagen molecules, which results in this type of hypochondrogenesis by affecting tissues that are rich in type II collagen. (wikipedia.org)
- The resulting abnormal type II collagen molecules are shorter than normal, causing the signs and symptoms of Kniest dysplasia. (wikipedia.org)
- The substitution of another amino acid for glycine in this chain inhibits the formation of stable, triple-stranded, ropelike collagen molecules. (wikipedia.org)
- Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. (wikipedia.org)
- This mutation prevents collagen molecules from being assembled properly, which disrupts the structure of type XI collagen. (wikipedia.org)
- Using NeoCell's technologically advanced hydrolyzation process, large collagen molecules are enzyematically hydrolyzed into small peptides that are both bioavailable and bioactive in the body. (puritan.com)
- Collagen VI molecules are made up of three alpha chains: α1(VI), α2(VI), and α3(VI). (wikipedia.org)
- thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. (wikipedia.org)
- To elucidate the role of extracellular matrix and basement membrane associated proteins at the ectodermal-ectomesenchymal interface of developing salivary glands, human fetal submandibular glands (n=100), gestational age varying from 10 to 40 weeks, were evaluated for expression of tenascin, type IV collagen and laminin by using immunohistochemical methods and the results were compared with their expression in adult glands (n=20). (nii.ac.jp)
- Type IV collagen and laminin were observed in the basement membrane of salivary ducts and acini beginning from 16-18 weeks, and the intensity of reaction was more prominent during intermediate developing stages (19-32 weeks). (nii.ac.jp)
- The present study suggests that tenascin forms an epithelial-ectomesenchymal interface before the organization of collagen IV and laminin in the basement membrane of salivary ducts and acini in developing human submandibular glands. (nii.ac.jp)
- Serum laminin and type IV collagen are accurate markers of histologically severe alcoholic hepatitis in patients with cirrhosis. (nih.gov)
- The aim of this study was to determine the accuracy of 5 extracellular matrix serum markers, i.e. laminin (Lam), N-terminal peptide of type III procollagen (PIIINP), type I (CI), type III (CIII) and type IV (CIV) collagens in identifying patients with severe histologic alcoholic hepatitis from among those with cirrhosis and suspected alcoholic hepatitis. (nih.gov)
- The best model included LAMC2 , encoding laminin-γ2 chain, and COL4A1 , encoding collagen, type IV α1 chain. (aacrjournals.org)
- We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. (rsc.org)
- Type VII collagen appears to play a key role in tumor invasion, and appears to operate through association with laminin-5. (stanford.edu)
- The molecule collagen XVII is closely associated with laminin-5 and a6b4 integrin and also is required for tumor invasion. (stanford.edu)
- The major components are laminin, type IV collagen, protéoglycan héparan-sulfate and entactin. (sigmaaldrich.com)
- 9 10 11 The structure of two scavenger receptors, recently explored by cloning cDNA from bovine lung library and designated type I and type II, was found to contain a collagenous domain, which plays a key role in binding chemically modified proteins, such as acetylated LDL, ox-LDL, and maleylated bovine serum albumin. (ahajournals.org)
- Determination of the complete cDNA sequence of rat type II collagen and evaluation of distinct expression patterns of types IIA and IIB procollagen mRNAs during fracture repair in rats. (biomedsearch.com)
- First, we sequenced the rat collagen type II cDNA to design the primers. (biomedsearch.com)
- 8. The isolated nucleic acid of claim 7 , which is a cDNA. (google.com)
- 1992). "Genomic organization and full-length cDNA sequence of human collagen X". FEBS Lett. (wikipedia.org)
- 1988). "Sequence analysis of murine cytokeratin endo A (no. 8) cDNA. (wikipedia.org)
- There are 29 genetically distinct collagens present in animal tissues. (news-medical.net)
- Type I collagen is found throughout the body except in cartilaginous tissues. (news-medical.net)
- However, at present there is no simple method for assessing the collagen-synthesizing and secreting activity of fibroblasts in human tissues. (jci.org)
- The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance between synthesis and degradation. (springer.com)
- Type II collagen is specific for cartilaginous tissues. (rcsb.org)
- Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. (wikipedia.org)
- Although it has many important functions in the body, collagen is best known for its structural role - providing a framework for tissues throughout the body. (nutraingredients.com)
- The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. (wikipedia.org)
- Tissues that are rich in type I collagen, such as the skin, bones, and tendons, are affected by this change. (wikipedia.org)
- These alterations negatively affect tissues that are rich in type I collagen, such as the skin, bones, teeth, and tendons, leading to the signs and symptoms of type III osteogenesis imperfecta. (wikipedia.org)
- All of these mutations prevent the normal production of mature type II collagen, which results in achondrogenesis, type 2 by affecting tissues that are rich in type II collagen. (wikipedia.org)
- This results in spondyloepimetaphyseal dysplasia, Strudwick type by affecting tissues that are rich in type II collagen. (wikipedia.org)
- Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. (wikipedia.org)
- Type XI collagen adds structure and strength to the tissues that support the body's muscles, joints, organs and skin (the connective tissue). (wikipedia.org)
- It is found within the dermal/epidermal junction, placental tissues, as well as in association with tissues containing Type-I collagen. (wikipedia.org)
- It is ubiquitously expressed in many tissues and cell types. (wikipedia.org)
- Within tissues, IGFBP-3 can bind IGF-1 and IGF-2 released by many cell types, and block their access to the IGF-1 receptor (IGF1R), which is activated by both IGFs. (wikipedia.org)
- A nuchal-type fibroma is a rare benign proliferation involving the dermis and subcutaneous tissues, that is a collection of dense, hypocellular bundles of collagen with entrapped adipocytes and increased numbers of small nerves. (wikipedia.org)
- In the absence of mutations, however, an autoimmune response against type VII collagen can result in an acquired form of this disease called epidermolysis bullosa acquisita. (wikipedia.org)
- Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy. (wikipedia.org)
- Mutations in the type VI collagen genes are associated with Bethlem myopathy and Ullrich congenital muscular dystrophy (UCMD). (wikipedia.org)
- Typically, both Bethlem myopathy and autosomal recessive UCMD patients are heterozygous for mutations in the three type VI collagen alpha chains, but only the former exhibit symptoms. (wikipedia.org)
- These COL2A1 mutations lead to the production of an abnormal version of the pro-alpha1(II) chain that cannot be incorporated into type II collagen fibers. (wikipedia.org)
- Kniest dysplasia: Most of the mutations responsible for Kniest dysplasia cause abnormally short pro-alpha1(II) collagen chains to be produced in the cell. (wikipedia.org)
- 1998). "Mutations of the alpha2(V) chain of type V collagen impair matrix assembly and produce ehlers-danlos syndrome type I". Hum. (wikipedia.org)
- These mutations prevent the normal assembly of type XI collagen. (wikipedia.org)
- Most of these mutations result in a complete lack of pro-alpha2(XI) chains, which leads to a loss of function of type XI collagen. (wikipedia.org)
- Some mutations affect the production of the pro-alpha2(XI) chain and disrupt normal collagen assembly. (wikipedia.org)
- COL11A2 mutations cause abnormal production of the pro-alpha2(XI) chain, part of type XI collagen. (wikipedia.org)
- reticulate (main component of reticular fibers ), commonly found alongside type I. (wikipedia.org)
- The cross-links result in the formation of very strong mature type I collagen fibers. (wikipedia.org)
- Ehlers-Danlos type IV is most attributed to abnormalities in the reticular fibers (collagen Type III). (wikipedia.org)
- The cross-linkages result in the formation of very strong mature type II collagen fibers. (wikipedia.org)
- Influence of nanofibers on the growth and osteogenic differentiation of stem cells-a comparison of biological collagen nanofibers and synthetic PLLA fibers. (springer.com)
- By microscopic examination, there are haphazardly arranged thick collagen fibers, with a low cellularity and no pleomorphism. (wikipedia.org)
- Normal healthy tendons are composed mostly of parallel arrays of collagen fibers closely packed together. (wikipedia.org)
- Collagen fibers are the most thrombogenic macromolecular components of the extracellular matrix, with collagen types I, III, and VI being the major forms found in blood vessels. (wikipedia.org)
- Deficiency causes one of the types of Ehlers-Danlos syndrome where collagen density is reduced and elastic fibers are fragmentated. (wikipedia.org)
- Fibromodulin participates in the assembly of the collagen fibers of the extracellular matrix. (wikipedia.org)
- The interterritorial space between the isogenous cell groups contains relatively more collagen fibers, causing it to maintain its shape while the actual cells shrink, creating the lacunae. (wikipedia.org)
- The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. (wikipedia.org)
- Collagen chains undergo several posttranslational modifications that are indispensable for proper collagen function. (pnas.org)
- Fitzgerald, J., Lamande, S. R., and Bateman, J. F. (1999) Proteasomal degradation of unassembled mutant type I collagen pro-alpha1(I) chains. (springer.com)
- In its natural form, collagen has a folded triple helix structure consisting of long polypeptide chains (see figure 1). (nutraingredients.com)
- The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. (wikipedia.org)
- The alpha 3 chain of type VI collagen is much larger than the alpha 1 and 2 chains. (wikipedia.org)
- This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, found in the amino terminal globular domain of all the alpha chains. (wikipedia.org)
- These short chains join with longer, normal-length collagen chains. (wikipedia.org)
- The pro-alpha2(XI) chain combines with pro-alpha1(XI) and pro-alpha1(II)collagen chains to form a procollagen molecule. (wikipedia.org)
- This chapter outlines several methods to assess the in vitro production of type I collagen that are employed in our laboratory. (springer.com)
- 8 On the other hand, ox-LDL was shown in vitro to bind to collagen gels. (ahajournals.org)
- In conclusion, our results show a novel action of orally active 8-OHdG in suppressing atherosclerotic plaque formation in vivo and VSMC activation in vitro through inhibition of Rac1, which emphasizes a new therapeutic avenue to benefit atherosclerosis. (nih.gov)
- Venugopal J, Ma LL, Yong T, Ramakrishna S. In vitro study of smooth muscle cells on polycaprolactone and collagen nanofibrous matrices. (springer.com)
- Runx2/Cbfa1-genetically engineered skeletal myoblasts mineralize collagen scaffolds in vitro. (springer.com)
- It also inhibits fibrillogenesis of collagen type I and collagen type III in vitro. (wikipedia.org)
- Type IV collagen is a major and crucial component of basement membranes. (pnas.org)
- α-Integrins dictate distinct modes of type IV collagen recruitment to basement membranes. (nih.gov)
- This particular collagen IV subunit, however, is only found in a subset of basement membranes. (wikipedia.org)
- Thus, COL4A1 is abundant and found in all types of basement membranes. (wikipedia.org)
- These include type II collagen in the cartilaginous zones, type III collagen in the reticulin fibres of the vascular walls, type IX collagen, type IV collagen in the basement membranes of the capillaries, type V collagen in the vascular walls, and type X collagen in the mineralized fibrocartilage near the interface with the bone. (wikipedia.org)
- Reviva's Elastin & Collagen Body Firming Lotion improves the appearance of slackened skin during weight loss and may help diminish the appearance of stretch marks. (pennherb.com)
- Includes powdered Elastin Concentrate and premium Soluble Collagen to soothe skin. (pennherb.com)
- The dry mass of normal tendons, which makes up about 30% of their total mass, is composed of about 86% collagen, 2% elastin, 1-5% proteoglycans, and 0.2% inorganic components such as copper, manganese, and calcium. (wikipedia.org)
- Although type IV collagen is reported to control axon targeting by regulating the concentration gradient of an axonal guidance molecule Slit, Slit overexpression did not affect the GC axons. (nih.gov)
- Hydrolysed collagen is manufactured via a specific hydrolysis process, where enzymes "cut" the triple helix molecule into smaller pieces, i.e. short-chain peptides. (nutraingredients.com)
- All of these changes interfere with the formation of the mature triple-stranded collagen molecule and prevent the production of mature type I collagen, which results in type IV osteogenesis imperfecta. (wikipedia.org)
- Collagen is used in bone grafting as it has a triple helical structure, making it a very strong molecule. (wikipedia.org)
- Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. (wikipedia.org)
- Two homotrimeric forms of type XVII collagen exist. (wikipedia.org)
- The membrane proximal part of the ectodomain, within amino acids 506-519, is responsible for binding to alpha 6 integrin, this binding seems to be important for the collagen XVII integration into hemidesmosomes (citation needed). (wikipedia.org)
- The largest collagenous domain, Col15, which contains 232 amino acids (amino acids 567-808), contributes significantly to stability of collagen XVII homotrimer. (wikipedia.org)
- Collagen XVII also plays a role as an autoantigen in acquired subepithelial blistering disorders. (wikipedia.org)
- Most immunodominant epitopes lie within the NC16A domain, and the binding of the autoantibodies perturbs adhesive functions of the collagen XVII, and this (together with inflammation-related processes) leads to epidermal-dermal separation and skin blistering. (wikipedia.org)
- Collagen XVII is constitutively shed from the keratinocyte surface within NC16A domain by TACE (TNF-Alpha Converting Enzyme), metalloproteinase of the ADAM family. (wikipedia.org)
- Collagen XVII is extracellularly phosphorylated by ecto-casein kinase 2 within the NC16A domain, phosphorylation negatively regulates ectodomain shedding. (wikipedia.org)
- Collagen XIII belongs to the transmembranous subfamily of collagens, like collagen XVII, XXIII and XXV. (wikipedia.org)
- Dystonin has been shown to interact with Collagen, type XVII, alpha 1, DCTN1 and Erbin. (wikipedia.org)
- Triple-helical peptides (THPs) have been utilized as collagen models since the 1960s. (rsc.org)
- COL4A1 belongs to the type IV collagen family and contains three domains: a short N-terminal domain, a long triple-helical 7S domain at its center, and a non-collagenous 1 (NC1) domain at its C-terminal. (wikipedia.org)
- This enzyme catalyses the following chemical reaction Cleavage of interstitial collagens in the triple helical domain. (wikipedia.org)
- The hemopexin domain is important to facilitate the cleavage of triple helical interstitial collagens. (wikipedia.org)
- Homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. (genecards.org)
- Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. (wikipedia.org)
- Pro-alpha 1(XI) collagen. (wikipedia.org)
- This mutation causes the amino acid glycine to be replaced with the amino acid glutamic acid at position 955 in the alpha 2 chain of type XI collagen (written as Gly955Glu). (wikipedia.org)
- Recombinant analysis of human alpha 1 (XVI) collagen. (wikipedia.org)
- Alpha collagen is specifically designed to deliver specific ratios of α- chain peptides as building blocks. (wikipedia.org)
- Scientists believe that Alpha collagen can help to deliver specific ratios of peptides to benefit the targeted cells. (wikipedia.org)
- Alpha collagen is designed to be used as a supplement for osteoarthritis, based on the theory of the different environments of the extracellular matrix (ECM). (wikipedia.org)
- The alpha 1 subunit contains an inserted (I) von Willebrand factor type I domain which is thought to be involved in collagen binding. (wikipedia.org)
- Schmid metaphyseal chondrodysplasia is a type of chondrodysplasia associated with a deficiency of collagen, type X, alpha 1. (wikipedia.org)
- Insoluble Type I collagen from bovine Achilles tendon (Sigma C9879) was suspended in a 3 mM solution of the dye diEd66Br dissolved in Cremophor EL R (BASF) to give a molecular concentration ratio. (spie.org)
- Both human and bovine collagen is widely used as dermal fillers for treatment of wrinkles and skin aging. (wikipedia.org)
- Most medical collagen is derived from young beef cattle (bovine) from certified BSE -free animals. (wikipedia.org)
- Calorad Classic is a liquid dietary supplement composed primarily of 3,000 mg (3 grams) of Type II hydrolyzed collagen (hydrolysate) from either beef (bovine) or tuna (marine) sources and 8 mg of aloe vera, both of which are listed as active ingredients. (wikipedia.org)
- In corneas we can find two different types of proteoglycans: Chondroitin sulphate/dermatan sulphate (CD/DS) and keratan sulphate (KS). (wikipedia.org)
- A balance between attractive and repulsive forces is reached for specific inter-fibrillar distances, which depends on the type of proteoglycans present. (wikipedia.org)
- Type I procollagen carboxyterminal domains are proteolytically removed during collagen secretion. (jci.org)
- We developed and characterized a monoclonal antibody (Anti-pC) specific for the carboxyterminal propeptide of type I procollagen. (jci.org)
- Type I collagen production is inhibited by the inability of the altered procollagen strands to associate and form the triple-stranded, ropelike structure of mature collagen. (wikipedia.org)
- Bone turnover was evaluated by analysing serum levels of C-terminal telopeptide of type I collagen (sCTX), and bone-specific alkaline phosphatase. (springer.com)
- Collagen has been widely used in cosmetic surgery, as a healing aid for burn patients for reconstruction of bone and a wide variety of dental, orthopedic, and surgical purposes. (wikipedia.org)
- Three types of solution processes, hydrothermal (H), electrochemical (E), and hydrothermal-electrochemical (HE), were performed on the Ti-29Nb-13Ta-4.6Zr alloy (TNTZ) to improve its bioactivity, and their bioactivities were measured in vivo using bone-implant contacts (BICs). (bireme.br)
- Several studies have shown that a daily intake of hydrolyzed collagen increases bone mass density in rats. (wikipedia.org)
- It seems that hydrolyzed collagen peptides stimulated differentiation and osteoblasts activity- the cells that build bone- over that of osteoclasts (cells that destroy bone). (wikipedia.org)
- Osteonectin also shows affinity for collagen in addition to bone mineral calcium. (wikipedia.org)
- Osteonectin is an acidic extracellular matrix glycoprotein that plays a vital role in bone mineralization, cell-matrix interactions, and collagen binding. (wikipedia.org)
- Thus, PPIB is essential for collagen biosynthesis and post-translational modification and affects fibril assembly, matrix cross-linking, and bone mineralization. (wikipedia.org)
- Collagen-related diseases most commonly arise from genetic defects or nutritional deficiencies that affect the biosynthesis, assembly, postranslational modification, secretion, or other processes involved in normal collagen production. (news-medical.net)
- Hydrolyzed collagen contains 8 out of 9 essential amino acids, including glycine and arginine-two amino-acid precursors necessary for the biosynthesis of creatine. (wikipedia.org)
- Epidermolysis bullosa acquisita involves an autoimmune reaction to this form of collagen. (wikipedia.org)
- Hydrolyzed collagen is a form of collagen and is also referred to as collagen hydrolysate, gelatine, gelatine hydrolysate, hydrolyzed gelatine, and collagen peptides. (wikipedia.org)
- Collagen VI is a form of collagen primarily associated with the extracellular matrix of skeletal muscle. (wikipedia.org)
- It has been reported that biglycan interacts more strongly with collagen type II than collagen type I. Biglycan has been reported to compete with decorin for the same binding site on collagen. (wikipedia.org)
- Decorin has been shown to interact with: Collagen type I Epidermal growth factor receptor and TGF beta 1, TLR2, and TLR4. (wikipedia.org)
- The effects of 8-OHdG observed in primary VSMCs were consistent with the in vivo effects of 8-OHdG and were inhibitory to angiotensin II or platelet-derived growth factor-induced production of reactive oxygen species, proliferation, migration, and ECM production. (nih.gov)
- Mechanical properties and cellular proliferation of electrospun collagen type II. (springer.com)
- In a normal wall of arteries, collagen type IV acts to inhibit smooth muscle cell proliferation. (wikipedia.org)
- TGF-β is a multifunctional set of peptides that controls proliferation, differentiation, and other functions in many cell types. (wikipedia.org)
- We assign a molecular function for prolyl 3-hydroxyl groups in type IV collagen. (pnas.org)
- vWF multimers of lower molecular weight show less binding to platelets in the presence of ristocetin 14 and less binding to collagen. (ahajournals.org)
- Molecular docking study showed that 8-OHdG stabilizes Rac1-GEF complex, indicating the physical contact of 8-OHdG with Rac1. (nih.gov)
- The process of hydrolysis involves breaking down the molecular bonds between individual collagen strands and peptides using combinations of physical, chemical or biological means. (wikipedia.org)
- Among its related pathways are ERK Signaling and Collagen chain trimerization . (genecards.org)
- Subsequent modeling without these two markers showed that COL1A1 , encoding collagen, type I α1 chain, and PADI1 , encoding peptidyl arginine deiminase, type 1, could also distinguish OSCC from controls. (aacrjournals.org)
- Heterotrimeric THPs have been utilized to better appreciate the contributions of chain sequence diversity on collagen function. (rsc.org)
- Instead, another type of collagen chain replaces pro-alpha2(XI) to form type XI collagen in the vitreous of the eye. (wikipedia.org)
- The targeted cells can process the α- chain peptides to form triple helix collagen, and replenish the collagen in the targeted site. (wikipedia.org)
- The C-type CRDs are each separated by linker regions of 10-20 amino acids containing a number of proline residues, whose cyclic side chain is fairly rigid and favours a conformation in which the N-terminal cysteine-rich domain is extended as far away from the plasma membrane as possible. (wikipedia.org)
- however, type I and type II are stabilized by intra-chain disulfide bonds, while type III modules do not contain any disulfide bonds. (wikipedia.org)
- Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. (wikipedia.org)
- The original focus for THP -based research was to unravel the structural determinants of collagen . (rsc.org)
- In the last two decades, virtually all aspects of collagen structural biochemistry have been explored with THP models. (rsc.org)
- Collagen VI is a major structural component of microfibrils. (wikipedia.org)
- When studying the influence of Na + , K + , Ca 2+ , Mg 2+ (equivalent to their concentrations in the interstitial fluid), native LDL, moderately ox-LDL, and highly ox-LDL showed the same affinity to type I collagen. (ahajournals.org)
- Unlike EC 220.127.116.11, interstitial collagenase, this enzyme cleaves type III collagen more slowly than type I This enzyme belongs to the peptidase family M10. (wikipedia.org)
- Telocytes are a novel defined type of interstitial (stromal) cells, in the field of Stem cells, with very long (tens to hundreds of micrometres) and very thin prolongations (mostly below the resolving power of light microscopy). (wikipedia.org)