A non-fibrillar collagen originally found in DESCEMET MEMBRANE. It is expressed in endothelial cell layers and in tissues undergoing active remodeling. It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains.
Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.
An x-linked recessive hepatic glycogen storage disease resulting from lack of expression of phosphorylase-b-kinase activity. Symptoms are relatively mild; hepatomegaly, increased liver glycogen, and decreased leukocyte phosphorylase are present. Liver shrinkage occurs in response to glucagon.
A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
A layer of the cornea. It is the basal lamina of the CORNEAL ENDOTHELIUM (from which it is secreted) separating it from the CORNEAL STROMA. It is a homogeneous structure composed of fine collagenous filaments, and slowly increases in thickness with age.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.
Enzymes that catalyze the degradation of collagen by acting on the peptide bonds.
A member of the MATRIX METALLOPROTEINASES that cleaves triple-helical COLLAGEN types I, II, and III.
A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC
A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.
An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.
The mechanical process of cooling.
Insurance designed to compensate persons who lose wages because of illness or injury; insurance providing periodic payments that partially replace lost wages, salary, or other income when the insured is unable to work because of illness, injury, or disease. Individual and group disability insurance are two types of such coverage. (From Facts on File Dictionary of Health Care Management, 1988, p207)
An independent agency within the Executive Branch of the United States Government. It administers a national social insurance program whereby employees, employers, and the self-employed pay contributions into pooled trust funds. Part of the contributions go into a separate hospital insurance trust fund for workers at age 65 to provide help with medical expenses. Other programs include the supplemental social security income program for the aged, blind, and disabled and the Old Age Survivors and Disability Insurance Program. It became an independent agency March 31, 1995. It had previously been part of the Department of Health, Education, and Welfare, later the Department of Health and Human Services. (From United States Government Manual, 1994-95)
Government sponsored social insurance programs.
A plant genus of the family LINACEAE that is cultivated for its fiber (manufactured into linen cloth). It contains a trypsin inhibitor and the seed is the source of LINSEED OIL.
The fixed oil obtained from the dried ripe seed of linseed, Linum usitatissimum (L. Linaceae). It is used as an emollient in liniments, pastes, and medicinal soaps, and in veterinary medicine as a laxative. It is also called flaxseed oil. (Dorland, 28th ed)
Disorder caused by loss of endothelium of the central cornea. It is characterized by hyaline endothelial outgrowths on Descemet's membrane, epithelial blisters, reduced vision, and pain.
Bilateral hereditary disorders of the cornea, usually autosomal dominant, which may be present at birth but more frequently develop during adolescence and progress slowly throughout life. Central macular dystrophy is transmitted as an autosomal recessive defect.
Single layer of large flattened cells covering the surface of the cornea.
A surgical procedure or KERATOPLASTY involving selective stripping and replacement of diseased host DESCEMET MEMBRANE and CORNEAL ENDOTHELIUM with a suitable and healthy donor posterior lamella. The advantage to this procedure is that the normal corneal surface of the recipient is retained, thereby avoiding corneal surface incisions and sutures.
Partial or total replacement of all layers of a central portion of the cornea.
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
The functions and properties of living organisms, including both the physical and chemical factors and processes, supporting life in single- or multi-cell organisms from their origin through the progression of life.
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
Basic glycoprotein members of the SERPIN SUPERFAMILY that function as COLLAGEN-specific MOLECULAR CHAPERONES in the ENDOPLASMIC RETICULUM.
ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.
Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.
Creation and development of bodies within solar systems, includes study of early planetary geology.
A non-fibrillar collagen involved in anchoring the epidermal BASEMENT MEMBRANE to underlying tissue. It is a homotrimer comprised of C-terminal and N-terminal globular domains connected by a central triple-helical region.
Form of epidermolysis bullosa characterized by trauma-induced, subepidermal blistering with no family history of the disease. Direct immunofluorescence shows IMMUNOGLOBULIN G deposited at the dermo-epidermal junction.
Form of epidermolysis bullosa characterized by atrophy of blistered areas, severe scarring, and nail changes. It is most often present at birth or in early infancy and occurs in both autosomal dominant and recessive forms. All forms of dystrophic epidermolysis bullosa result from mutations in COLLAGEN TYPE VII, a major component fibrils of BASEMENT MEMBRANE and EPIDERMIS.
Group of genetically determined disorders characterized by the blistering of skin and mucosae. There are four major forms: acquired, simple, junctional, and dystrophic. Each of the latter three has several varieties.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Visible accumulations of fluid within or beneath the epidermis.

Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy. (1/44)

Corneal clarity is maintained by its endothelium, which functions abnormally in the endothelial dystrophies, leading to corneal opacification. This group of conditions includes Fuchs' endothelial dystrophy of the cornea (FECD), one of the commonest indications for corneal transplantation performed in developed countries, posterior polymorphous dystrophy (PPCD) and the congenital hereditary endothelial dystrophies (CHED). A genome-wide search of a three-generation family with early-onset FECD demonstrated significant linkage with D1S2830 (Z(max) = 3.72, theta = 0.0). Refinement of the critical region defined a 6-7 cM interval of chromosome 1p34.3-p32 within which lies the COL8A2 gene. This encodes the 703 amino acid alpha2 chain of type VIII collagen, a short-chain collagen which is a component of endothelial basement membranes and which represented a strong candidate gene. Analysis of its coding sequence defined a missense mutation (gln455lys) within the triple helical domain of the protein in this family. Mutation analysis in patients with FECD and PPCD demonstrated further missense substitutions in familial and sporadic cases of FECD as well as in a single family with PPCD. This is the first description of the molecular basis of any of the corneal endothelial dystrophies or of mutations in type VIII collagen in association with human disease. This suggests that the underlying pathogenesis of FECD and PPCD may be related to disturbance of the role of type VIII collagen in influencing the terminal differentiation of the neural crest derived corneal endothelial cell.  (+info)

Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis. (2/44)

Type VIII collagen is upregulated after vessel injury, and this collagen has been implicated in both smooth muscle cell migration and angiogenesis. This study examines the temporal and spatial pattern of expression of type VIII collagen in porcine coronary vessels at specific time points after balloon angioplasty. In situ hybridization studies demonstrated that collagen VIII messenger ribonucleic acid (mRNA) was markedly elevated in the neoadventitia at 3 days post-angioplasty. By 14 days, elevated collagen VIII message was seen mainly in the neointima and this expression decreased to background levels by 90 days. The distribution of collagen VIII protein, detected using immunohistochemistry, was similar but the up-regulation lagged behind the mRNA increase by a few days. Pre-treatment of sections with pepsin highlighted variations in the organization and appearance of extracellular collagen VIII containing structures in both injured and normal vessels. New vessel formation was evident in the neoadventitia after 3 days, but there was no colocalization of type VIII collagen immunostaining with that of von Willebrand factor (a marker of endothelial cells) in the neoadventitia. These data show that up-regulation of collagen VIII in the neoadventitia is an important early marker of the coronary arterial response to injury, and is not associated with new vessel formation.  (+info)

Human corneal epithelial cell viability and morphology after dilute alcohol exposure. (3/44)

PURPOSE: To determine the effect of dilute alcohol on human corneal epithelial cellular morphology and viability. Dilute alcohol is used for epithelial removal during photorefractive keratectomy (PRK) and laser subepithelial keratomileusis (LASEK). METHODS: Corneal epithelial sheets harvested from human eyes after alcohol application during PRK were examined by light and electron microscopy (specimens I-IV). In addition, tissue cultures of human epithelial sheets were monitored for epithelial migration and attachment (specimens V-VII). To determine the effect of dilute alcohol on epithelial cell viability, simian virus (SV)40-immortalized human corneal epithelial cells were exposed to dilute alcohol in distilled water (EtOH-H2O) or to keratinocyte serum-free medium (EtOH-KSFM) for incubation periods of 20 to 45 seconds and concentrations of 10% to 70%. Cell membrane permeability and intracellular esterase activity were analyzed by calcein-acetoxymethyl ester (AM)/ethidium homodimer assay. TdT-mediated dUTP nick-end labeling (TUNEL) assay was used to detect apoptotic cells at 0, 8,12, 24, and 72 hours. RESULTS: Electron microscopy showed varying degrees of basement membrane alterations after alcohol application, including disruptions, discontinuities, irregularities, and duplication (specimens I-IV). Cellular destruction and vacuolization of basal epithelial cells associated with absent basement membrane were also observed (specimen III). One of three cultured epithelial sheets showed attachment and outgrowth in the tissue culture until day 15 (specimen V). Twenty-second exposure of cultured immortalized human cells to various concentrations of EtOH-H2O showed significant reduction of viable cells when EtOH-H2O concentration exceeded 25% (P = 0.005). Increasing the duration of application of 20% EtOH-H2O beyond 30 seconds resulted in a significant reduction in viable cells (69.69% +/- 16.34% at 30 seconds compared with 2.14% +/- 2.29%, 10.45% +/- 7.11%, and 11.09% +/- 15.73% at 35, 40, and 45 seconds, respectively; P = 0.01). TUNEL assay of cultured human corneal epithelial cells exposed to 20% EtOH-H(2)O for 20 and 40 seconds showed maximal labeling at 24 hours (58.05% +/- 33.10%) and 8 hours (94.12% +/- 1.21%), respectively. Exposure to 20% EtOH-KSFM for 20 and 40 seconds resulted in substantially lower TUNEL positivity (3.51% +/- 0.20% at 24 hours and 7.11% +/- 0.49% at 8 hours). CONCLUSIONS: The viability and electron microscopic findings in the basement membrane zone showed significant variation after treatment of the epithelium in vivo with dilute alcohol. The application of dilute alcohol on the monolayer of cultured corneal epithelial cells resulted in increasing cell death in a dose- and time-dependent manner.  (+info)

Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. (4/44)

Estrogen exerts a variety of important physiological effects, which have been suggested to be mediated via the two known estrogen receptors (ERs), alpha and beta. Three-month-old ovariectomized mice, lacking one or both of the two estrogen receptors, were given estrogen subcutaneously (2.3 micro g/mouse per day) and the effects on different estrogen-responsive parameters, including skeletal effects, were studied. We found that estrogen increased the cortical bone dimensions in both wild-type (WT) and double ER knockout (DERKO) mice. DNA microarray analysis was performed to characterize this effect on cortical bone and it identified four genes that were regulated by estrogen in both WT and DERKO mice. The effect of estrogen on cortical bone in DERKO mice might either be due to remaining ERalpha activity or represent an ERalpha/ERbeta-independent effect. Other effects of estrogen, such as increased trabecular bone mineral density, thymic atrophy, fat reduction and increased uterine weight, were mainly ERalpha mediated.  (+info)

Identification of genes induced in regenerating Xenopus tadpole tails by using the differential display method. (5/44)

To identify candidate gene(s) involved in the tail regeneration of Xenopus laevis tadpoles, we used the differential display method to isolate four genes (clones 1, 2, 13a, and 13b) whose expression is induced in regenerating tadpole tails. Among them, clones 13a and 13b were found to encode the Xenopus homologues of the alpha1 chain of type XVIII collagen and neuronal pentraxin I, respectively. Expression of clone 2 and neuronal pentraxin I genes increased dramatically in the blastema 3 days after amputation, whereas that for the clone 1 and type XVIII collagen genes was induced gradually after amputation. In situ hybridization revealed that the neuronal pentraxin I gene is expressed specifically in the regenerating tail epidermis but not in the normal tail epidermis or the most distal margin of the tail blastema, suggesting that it has a tissue-inductive role in tail regeneration. Expression of the four genes was induced in the limb and in the tail blastema, suggesting that they are involved in the regeneration of both organs. Finally, expression of clone 2 and neuronal pentraxin I genes was scarce during embryonic stages in comparison to the tail blastema, suggesting that their main functions are in organ regeneration. Our results demonstrate unique features of spatial and temporal gene expression patterns during Xenopus tadpole tail regeneration.  (+info)

Molecular targets for tumour progression in gastrointestinal stromal tumours. (6/44)

BACKGROUND AND AIMS: The distinction between benign and malignant gastrointestinal stromal tumours (GISTs) is often unclear at the clinical and histopathology levels. GISTs are believed to arise from the stem cells of Cajal. In order to define genetic biomarkers and identify target genes related to GIST progression, we analysed and compared benign and malignant GISTs with verified follow up data using cDNA expression arrays. METHODS: Eight genes were frequently overexpressed in malignant GISTs and their overexpression was confirmed using quantitative real time reverse transcription-polymerase chain reaction. These genes included ezrin (villin 2 (VIL2)), collagen 8 alpha 1 subunit (COL8A1), G2/mitotic specific cyclin B1 (CCNB1), high mobility group protein (HMG2), TSG101 tumour susceptibility protein, CENP-F kinetochore protein, protein tyrosine kinase 2 (FAK), and protein kinase DYRK2. To test these genes in a clinical setting, we obtained diagnostic samples of 16 additional GISTs that were classified at diagnosis as benign, malignant, and uncertain malignant potential (UMP). RESULTS: There was remarkable gene overexpression in all malignant GISTs. Statistical analyses revealed significant correlations between overexpression of several gene pairs in malignant GISTs. We found the strongest correlations (rho>0.70) among the significant correlations (p<0.01) between CCNB1-CENP-F (rho = 0.87) and CCNB1-FAK (rho = 0.73). Gene expression of the UMP GISTs suggested two different groups. Three UMP GISTs had gene expression consistent with malignant tumours and their follow up data revealed that indeed these patients had recurrences later on. On the other hand, UMP GISTs that had low gene expression levels continued free of disease for several years. CONCLUSIONS: These results provide insight into the oncogenesis of GISTs and suggest that testing the expression profile of a number of genes may segregate GISTs into groups of different tumour behaviour.  (+info)

Expression and supramolecular assembly of recombinant alpha1(viii) and alpha2(viii) collagen homotrimers. (7/44)

Collagen VIII is an extracellular matrix macromolecule comprising two polypeptide chains, alpha1(VIII) and alpha2(VIII), that can form homotrimers in vitro and in vivo. Here, recombinant collagen VIII was expressed to study its supramolecular assembly following secretion. Cells transfected with alpha1(VIII) or alpha2(VIII) assembled and secreted homotrimers that were stable in denaturing conditions and had a molecular mass of approximately 180 kDa on SDS-PAGE gels. Co-transfection with prolyl 4-hydroxylase generated homotrimers with stable pepsin-resistant triple-helical domains. Size fractionation of native recombinant collagen VIII molecules expressed with or without prolyl 4-hydroxylase identified urea-sensitive high molecular mass assemblies eluting in the void volume of a Superose 6HR 10/30 column and urea-resistant assemblies of approximately 700 kDa, all of which were composed of homotrimers. Immunofluorescence analysis highlighted the extracellular deposition of recombinant alpha1(VIII)(3), alpha2(VIII)(3), and co-expressed alpha1(VIII)(3)/alpha2(VIII)(3). Microscopy analysis of recombinant collagen VIII identified rod-like molecules of 134 nm in length that assembled into angular arrays with branching angles of approximately 114 degrees and extensive networks. Based on these data, we propose a model of collagen VIII assembly in which four homotrimers form a tetrahedron stabilized by central interacting C-terminal NC1 trimers. Tetrahedrons may then act as building blocks of three-dimensional hexagonal lattices generated by secondary interactions involving terminal and helical sequences.  (+info)

Endostatin promotes the anabolic program of rabbit chondrocyte. (8/44)

Endostatin is a natural occurred angiogenesis inhibitor derived from collagenXVIII. So far its function during the angiogenesis process of bone formation and arthropathy has not been well studied yet. The present study addresses the function of endostatin in rabbit articular chondrocytes (RAC). We found that endostatin can promote RAC adhesion and spreading as well as its proliferation. In monolayer cultured RAC, CollagenII, TIMP1 and collagenXVIII transcription were up regulated by endostatin while collagenI and MMP9 were down regulated. Moreover collagenXVIII and endostatin antigens are present at synovial fluid. These findings indicate new function of endostatin as a homeostatic factor in cartilage metabolism.  (+info)

TY - JOUR. T1 - Collagen VIII is expressed by vascular smooth muscle cells in response to vascular injury. AU - Sibinga, Nicholas E S. AU - Foster, Lauren C.. AU - Hsieh, Chung Ming. AU - Perrella, Mark A.. AU - Lee, Wen Sen. AU - Endege, Wilson O.. AU - Sage, E. Helene. AU - Lee, Mu En. AU - Haber, Edgar. PY - 1997. Y1 - 1997. N2 - To identify genes involved in vascular remodeling, we applied differential mRNA display analysis to the rat carotid artery balloon injury model. One polymerase chain reaction product showing increased expression at days 2 to 14 after vascular injury was nearly identical to the mouse α1 chain of type VIII collagen, a heterotrimeric short-chain collagen of uncertain function expressed by a limited number of cell types. By Northern analysis, expression of both chains of the type VIII collagen heterotrimer increased: collagen α1 (VIII) mRNA expression was almost 4-fold higher than control by 7 days after vascular injury, and collagen α2 (VIII) mRNA expression reached ...
Collagen VIII alpha 1兔多克隆抗体(ab100988)可与人样本反应并经WB实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets.
View mouse Col8a2 Chr4:126286793-126314330 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Mehta, J.S., Vithana, E.N., Tan, D.T.H., Yong, V.H.K., Aung, T., Yam, G.H.F., Law, R.W.K., Pang, C.P. (2008). Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset fuchs endothelial corneal dystrophy. Investigative Ophthalmology and Visual Science 49 (1) : 184-188. [email protected] Repository. https://doi.org/10.1167/iovs.07- ...
Purpose : Fuchs endothelial corneal dystrophy (FECD) is an autosomal dominant disease with assorted variations in expression and penetrance. The expansion of a CTG trinucleotide repeat (TNR) in a different intron of transcription factor 4 (TCF4) has commonly been detected in FECD patients, and the sensitivity and specificity of ,50 repeats was 79% and 96%, respectively (Wieben et al., PloS ONE, 2012). The purpose of this present study was to evaluate the TNR expansion in a larger cohort of Caucasian FECD patients. Methods : We recruited 387 FECD patients (158 males and 229 females; mean age: 69.7±9.2 years; range: 32-92 years) who were scheduled to receive Descemets membrane endothelial keratoplasty (DMEK) at the University of Erlangen-Nürnberg Hospital in order to obtain peripheral blood samples. All patients were diagnosed as FECD due to symptoms such as guttae, corneal edema, and decrease of corneal endothelial cell density. Purification of genomic DNA from each patients blood sample was ...
Purpose : Fuchs Endothelial Corneal Dystrophy (FECD) is a late-onset oxidative stress-induced disease characterized by progressive loss of corneal endothelial cells. We previously reported increased mitochondrial fragmentation as a possible phenomenon that explained the pathomechanism of FECD. The aim of this study is to further decipher the key checkpoints involved in mitochondrial quality control that may be aberrantly regulated in FECD. Methods : Tissue lysates prepared from post-keratoplasty specimens from late-onset FECD cases were compared with age-matched normal donor specimens (n=3 for each group) for PINK1, phosphoParkin(Ser65), phospho-Drp1(Ser616), phosphoDrp1(Ser637). Whole cell lysates of human corneal endothelial cell line immortalized with hTert (HCEnC-21T) were treated with 50mM menadione (MN) and 10nM Bafilomycin A1 for 20 hours. HCEnC-21T cells were transfected with YFP-Parkin, fragmentation was induced with 50mM MN, and mitochondria were visualized with immunofluorescence ...
Fuchs endothelial corneal dystrophy (FECD) MIM#136800 and posterior polymorphous corneal dystrophy (PPCD) MIM#122000 both belong to the corneal endothelial dystrophies in which endothelial dysfunction can lead to corneal oedema. In addition, they both share the common features of endothelial metaplasia and the secretion of an abnormal Descemets membrane as a pathological posterior collagenous layer (PCL) with a small or absent posterior non-banded zone.1,2. The exact cause of both FECD and PPCD is still unknown, although both are thought to be the result of a disorder of neural crest terminal differentiation.3 Mutations in COL8A2, the gene for the α2(VIII) chain of type VIII collagen, have previously been described in patients with both FECD and PPCD,4,5 and type ...
Arch Ophthalmol. 2012 Apr;130(4):433-9. doi: 10.1001/archopthalmol.2011.1626. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt
Expertise, Disease and Conditions: Cataract Surgery, Cataracts, Cornea Transplant, Cornea/Anterior Segment Disease, Corneal Disorders, Corneal Dystrophies, Corneal Ulcer, Dry Eyes, Fuchs Dystrophy of the Cornea, Fuchs Endothelial Corneal Dystrophy, Herpes Infections, Keratoconus, Laser Surgery, Ophthalmology, Refractive Surgery, Thyroid Eye Disease, ...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2010 ...
A novel pathogenic L450W COL8A2 mutation was identified and its highly distinctive pathology characterized. This indicates that COL8A2 mutations give rise to a rare subtype of FCD. This study also provides the first direct evidence that COL8A2-FCD progresses from early to late stages in 25 years, a …
Corneal-endothelial-vesicles Symptom Checker: Possible causes include Polymorphous Corneal Dystrophy. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
Researchers at Mayo Clinic have identified the specific genetic defect in the TCF4 gene - the expansion of the TGC repeat - that appears to be responsible for Fuchs endothelial corneal dystrophy (FECD).
Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 amino acid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells (adipokine). The protein belongs to the soluble defence collagen superfamily; it has a collagen-like domain structurally homologous with collagen VIII and X and complement factor C1q-like globular domain. Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. The human Adiponectin is expressed in E. coli as a recombinant 25.1 kDa sinle, non-glycosylated polypeptide chain containing 231 amino acid residues ...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy. [provided by RefSeq, Nov 2013 ...
RecName: Full=Adenylate cyclase type 8; EC=;AltName: Full=Adenylate cyclase type VIII;AltName: Full=ATP pyrophosphate-lyase 8;AltName: Full=Adenylyl cyclase 8;AltName: Full=Ca(2+)/calmodulin-activated adenylyl ...
Use SelfDecode to get personalized health recommendations based on your genes. Get started today with an existing DNA file or order a SelfDecode DNA kit!
Data scientist Thomas Fuchs develops and applies advanced machine learning and computer vision techniques for tackling large-scale computational pathology challenges in cancer research and clinical practice.
Kerstin Fuchs is the author of this article in the Journal of Visualized Experiments: Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent
I simply needed to thank you so much yet again. I do not know the things that I could possibly have tried without those recommendations shared by you relating to my question. It truly was a daunting matter in my position, however , noticing the very well-written manner you managed it forced me to cry for fulfillment. Now im grateful for the help as well as believe you know what an amazing job you were providing training many people via your site. I know that you have never met any of us.. ...
PURPOSE: To investigate the functional role that the zinc e-box binding homeobox 1 (ZEB1) gene, which underlies the genetic basis of posterior polymorphous corneal dystrophy 3 (PPCD3), plays in corneal endothelial cell proliferation, apoptosis, migration, and barrier function. METHODS: A human corneal endothelial cell line (HCEnC-21T) was transfected with siRNA targeting ZEB1 mRNA. Cell proliferation, apoptosis, migration, and barrier assays were performed: Cell proliferation was assessed with cell counting using a hemocytometer; cell apoptosis, induced by either ultraviolet C (UVC) radiation or doxorubicin treatment, was quantified by measuring cleaved caspase 3 (cCASP3) protein levels; and cell migration and barrier function were monitored with electric cell-substrate impedance sensing (ECIS ...
Findings published in the American Journal of Pathology offer new directions for treatment of patients with Fuchs Endothelial Corneal Dystrophy (FECD)
Do You Have Corneal Dystrophy, Fuchs Endothelial, 1? Join friendly people sharing true stories in the I Have Corneal Dystrophy, Fuchs Endothelial, 1 group. Find support forums, advice and chat with groups who share this life experience. A Corneal D...
From iuvax!bionet!embl.bitnet!FUCHS Mon Jun 25 09:29:36 EST 1990 Article 347 of bionet.software: Path: iuvax!bionet!embl.bitnet!FUCHS >From: [email protected] (Rainer Fuchs , EMBL Data Library) Newsgroups: bionet.software Subject: Molecular biological software/EMBL File Server Message-ID ...
As a global sensor manufacturer, Pepperl+Fuchs provides the highest-quality sensors for automation solutions. Pepperl+Fuchs is the ideal partner for factory automation projects that require industry-specific technologies.
Buy Fuchs «Extra» online: this off-dry red wine is very dense and has a fine fruitiness with a touch of sweetness. Histamine content 0.228 mg/l.
Pepperl+Fuchs offers a broad range of technologies to support your applications. Choose products and services that include SIL (safety integrity level), fieldbus advanced diagnostics and software solutions, or wireless HART communication
Web sitemizin düzgün çalıştığından emin olmak ve web sitemizi geliştirebilmek için kullanıcılar hakkında istatistiki bilgiler elde etmek amacıyla çerezler kullanmaktayız. Bu siteyi incelemeye devam etmeniz halinde, çerez kullanımımızı kabul etmiş olacaksınız. Devamını oku ...
Apidologie 43, 334-347. Dietemann, V., Pflugfelder, J., Anderson, D., Charriere, J.D., Chejanovsky, N., Dainat, B., de Miranda, J., Delaplane, K., Dillier, F.X., Fuchs, S., Gallmann, P., Gauthier, L., Imdorf, A., Koeniger, N., Kralj, J., Meikle, W., Pettis, J., Rosenkranz, P., Sammataro, D., Smith, D., Yanez, O., Neumann, P. (2012 ...
TY - JOUR. T1 - Evaluation of phacoemulsification-induced oxidative stress and damage of cultured human corneal endothelial cells in different solutions using redox fluorometry microscopy. AU - Nishi, Yutaro. AU - Engler, Christoph. AU - Na, Dae Ro. AU - Kashiwabuchi, Renata T.. AU - Shin, Young Joo. AU - Cano, Marisol. AU - Jun, Albert S.. AU - Chuck, Roy S.. PY - 2010/12/1. Y1 - 2010/12/1. N2 - Purpose: To describe the basic concept of redox fluorometry microscopy and investigate its efficacy in evaluating the state of cultured human corneal endothelial cells in different solutions when ultrasonic energy was applied in vitro. Methods: Human corneal endothelial cells from human donor tissue not suitable for transplantation were cultured. A phacoemulsification probe with a 30° round, 1.1- mm TurboSonics® ABS™ Tip (Alcon, Fort Worth, Texas) was introduced into culture dishes filled with balanced salt solution (BSS) and BSS plus (Alcon, Fort Worth, Texas). Cellular autofluorescence images were ...
FUCHS stands for performance and sustainability, for safety and reliability, for efficiency and cost savings. FUCHS stands for technology that pays back.
Less than a year ago the College of Engineering was in the midst of a search for a new dean and the plans for Duffield Hall seemed far-off. Now under the leadership of Dean W. Kent Fuchs, goals for the college include implementing a new biomedical engineering program, assessing the Colleges infrastructure and overseeing the completion and move-in to Duffield Hall.
Trappist Westvleteren 8 (VIII) is a Dubbel style beer brewed by Brouwerij Westvleteren (Sint-Sixtusabdij van Westvleteren) in Westvleteren, Belgium. 4.48 average with 2197 ratings, reviews and opinions.
Trappist Westvleteren 8 (VIII) is a Dubbel style beer brewed by Brouwerij Westvleteren (Sint-Sixtusabdij van Westvleteren) in Westvleteren, Belgium. 4.48 average with 2198 ratings, reviews and opinions.
Alport syndrome (AS) is characterized by renal, cochlear, and ocular involvement. In the absence of treatment, renal disease progresses from microscopic hematuria to proteinuria, progressive renal insufficiency, and end-stage renal disease (ESRD) in all males with X-linked (XL) AS, and in all males and females with autosomal recessive (AR) AS. Progressive sensorineural hearing loss (SNHL) is usually present by late childhood or early adolescence. Ocular findings include anterior lenticonus (which is virtually pathognomonic), maculopathy (whitish or yellowish flecks or granulations in the perimacular region), corneal endothelial vesicles (posterior polymorphous dystrophy), and recurrent corneal erosion. In individuals with autosomal dominant (AD) AS, ESRD is frequently delayed until later adulthood, SNHL is also relatively late in onset and ocular involvement is rare. Thin basement membrane nephropathy (TBMN) is characterized by persistent microscopic hematuria often first observed in childhood; ...
Visual system homeobox 1 is a protein that in humans is encoded by the VSX1 gene. The protein encoded by this gene contains a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior polymorphous corneal dystrophy (PPCD) and keratoconus. Two transcript variants encoding different isoforms have been found for this gene. GRCh38: Ensembl release 89: ENSG00000100987 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000033080 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Semina EV, Mintz-Hittner HA, Murray JC (Apr 2000). Isolation and characterization of a novel human paired-like homeodomain-containing transcription factor gene, VSX1, expressed in ocular tissues. Genomics. 63 (2): 289-93. doi:10.1006/geno.1999.6093. PMID 10673340. Entrez Gene: VSX1 visual system homeobox ...
Your cornea is the clear part of the front of the eye. Corneal dystrophies are common genetic conditions which cause changes to your cornea without any inflammation, infection or other eye disease. Corneal dystrophies affect the clearness of your cornea and usually involve both eyes. Although they can often get worse over time, normally this happens very slowly. Many corneal dystrophies develop so slowly that they may never get to a point where they affect your vision.
Corneal dystrophy comes in more than 20 types and occurs when material piles up in at least one of the five layers of the cornea. Corneal dystrophy can cause the cornea to lose its clarity, with the...
Alfonso VIII o Fernando II (hacia 1170). Dinero. Vellón. Sin marca de ceca. Figura de Fernando II coronado y estante a derecha S delante seguida por la de Alfonso VIII de niño y ·ALFOVN· con anillos al principio y final de la leyenda, cruz sobre menguante y dos puntos en el tercer y cuarto cuartel de la cruz y FRNANDVS REX con la S tumbada. RV119 de Alfonso VIII. Cy1048 de Alfonso VIII. AB158 de Alfonso VIII. 0´55 g. Algo sucia. MBC-. Estimación 600 €
GAINESVILLE Wednesday evening, hazy rumors of an impending Neo-Nazi march reached some wary protesters. A few quickly rallied to denounce the marchers in downtown Gainesville, only to find plazas e
The Essca Writing Group: Hegewald, J. and Uter, W. and Aberer, W. and Ayala, F. and Beliauskiene, A. and Belloni Fortina, A. and Bircher, A. J. and Brasch, J. and Chowdhury, M. M. U. and Coenraads, P. J. and Schuttelaar, M. L. A. and Elsner, P. and English, J. and Fartasch, M. and Mahler, V. and Frosch, P. J. and Fuchs, T. and Gawkrodger, D. and Giménez-Arnau, A. M. and Green, C. M. and Johansen, J. D. and Menné, T. and Jolanki, R. and King, C. M. and Krêcisz, B. and Kiec-Swierczynska, M. and Larese, F. and Ormerod, A. D. and Orton, D. and Peserico, A. and Rantanen, T. and Rustemeyer, T. and Sansom, J. E. and Statham, B. and Corradin, M. T. and Wallnofer, W. and Wilkinson, M. and Schnuch, A. ...
Daniela Zühlke, Kirsten Dörries, Jörg Bernhardt, Sandra Maaß, Jan Muntel, Volkmar Liebscher, Jan Pané-Farré, Katharina Riedel, Michael Lalk, Uwe Völker, Susanne Engelmann, Dörte Becher, Stephan Fuchs, Michael Hecker ...
This Histri was built automatically but not manually verified. As a consequence, the Histri can be incomplete or can contain errors ...
Fuchs Dystrophy is a type of corneal disease that affects the inner most layer of the cornea-the endothelium. Fuchs Dystrophy is slowly progressive, is found in both eyes and is slightly more common in women than men. While we can see Fuchs Dystrophy in people in their 30s and 40s, it usually does not compromise vision until people are in their 50s or 60s.. About Fuchs Dystrophy. The endothelial cells are responsible for pumping water out of the cornea and helping to maintain the corneal transparency. While the reason is poorly understood, in Fuchs Dystrophy, the endothelial cells die, which make the endothelium less efficient in its pumping activity. This results in the cornea swelling and distorting vision. Fuchs Dystrophy Risks & Severity. Researchers reporting in the journal Investigative Ophthalmology and Visual Science studied the effects of smoking, and other risk factors, on the development of advanced Fuchs endothelial corneal dystrophy (FECD) and on central corneal thickness ...
Looking for online definition of Meesmann-Wilke corneal dystrophy in the Medical Dictionary? Meesmann-Wilke corneal dystrophy explanation free. What is Meesmann-Wilke corneal dystrophy? Meaning of Meesmann-Wilke corneal dystrophy medical term. What does Meesmann-Wilke corneal dystrophy mean?
Looking for information on Dog Corneal Dystrophy (Corneal Opacities) in Manchester? We have compiled a list of businesses and services around Manchester that should help you with your search. We hope this page helps you find information on Dog Corneal Dystrophy (Corneal Opacities) in Manchester.
Looking for information on Dog Corneal Dystrophy (Corneal Opacities) in Stamford? We have compiled a list of businesses and services around Stamford that should help you with your search. We hope this page helps you find information on Dog Corneal Dystrophy (Corneal Opacities) in Stamford.
PURPOSE: To report the presence of the R124H mutation in two Spanish families with Avellino corneal dystrophy (ACD). METHODS: Two families with subjects who presented biomicroscopic features of ACD were included in this study. They have no relatives
Pharmacist Ben Fuchs radio show archives. Ben Fuchs archive is a directory of all the Bright Side Ben radio show broadcasts produced by the Genesis Communications Network - GCN, Youngevity and DR Joel Wallach
Pharmacist Ben Fuchs radio show archives. Ben Fuchs archive is a directory of all the Bright Side Ben radio show broadcasts produced by the Genesis Communications Network - GCN, Youngevity and DR Joel Wallach
If you are 70½ years old or older, you can make a tax free donation via your IRA to youir favorite charity Read More. Covered California Current members can renew or change their health plans until Jan. 31, 2018. Coverage now will start March 1, 2018. All other states are now closed. Please copy and paste to circulate.. ...
1896. Boston: Houghton Mifflin and Company, [1896]-1914. 20 volumes, 8vo., xix, [1]-444; xxxv, [1]-440; [viii], [1]-430; [vii], [1]-460; [viii], [1]-482; [viii], [1]-460; [viii], [1]-488; [viii], [1]-483; x, [1]-474; [viii], [1]-447; [viii], [1]-445; [xi], [1]-441; [vii], [1]-327; [vii], [1]-331; [viii], [1]-382; [viii], [1]-381; [viii], [1]-355; [viii], [1]-363; xxvi, [1]-433; xxvii, [1]-432..... More ...
Machado Y., R. Freier, S. Scheiblhofer, T. Thalhamer, M. Mayr, P. Briza, S. Grutsch, L. Ahammer, J. E. Fuchs, H. G. Wallnoefer, A. Isakovic, V. Kohlbauer, A. Hinterholzer, M. Steiner, M. Danzer, J. Horejs-Hoeck, F. Ferreira, K. R. Liedl, M. Tollinger, P. Lackner, C. M. Johnson, H. Brandstetter, J. Thalhamer and R. ...
Saur, Stefan C. and Alkadhi, Hatem and Stolzmann, Paul and Baumüller, Stephan and Leschka, Sebastian and Scheffel, Hans and Desbiolles, Lotus and Fuchs, Thomas J. and Székely, Gábor and Cattin, Philippe C. ...
Study VIII - Environmental and Nutritional Diseases flashcards from Valerie Queyquep's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
Study VIII - Environmental and Nutritional Diseases flashcards from Vanessa Almaden's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
Liu B, Weinzimer SA, Gibson TB, Mascarenhas D, Cohen P (2003). "Type Ialpha collagen is an IGFBP-3 binding protein". Growth ... Functional interactions with the EGF receptor and the type I/type II TGFβ receptor system have also been reported, and other ... IGFBP-3 exerts antiproliferative effects in many cell types by blocking the ability of IGF-1 and IGF-2 to activate the IGF1R ( ... Xue A, Scarlett CJ, Jackson CJ, Allen BJ, Smith RC (2008). "Prognostic significance of growth factors and the urokinase-type ...
It has been reported that biglycan interacts more strongly with collagen type II than collagen type I. Biglycan has been ... Pogány G, Hernandez DJ, Vogel KG (August 1994). "The in vitro interaction of proteoglycans with type I collagen is modulated by ... "Binding of the proteoglycan decorin to collagen type VI". J. Biol. Chem. 267 (8): 5250-6. PMID 1544908. Bowe MA, Mendis DB, ... "Interaction of biglycan with type I collagen". J. Biol. Chem. 270 (6): 2776-83. doi:10.1074/jbc.270.6.2776. PMID 7852349. ...
... especially actomyosin and Type I collagen, which is found in muscle joints.[8] ... The specificity of zingibain's binding ensures predominant hydrolyzation of actomyosin and Type I collagen. ... Zingibain exhibits complex-type N-linked oligosaccharide chains at two residues.[1] Chains are between 5-13 glycosyl units long ... Zingibain is also used to flavor sausages and baked products.[8] Rennet substitute[edit]. For over the past 100 years, ginger ...
Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). A closely related family member is the ... gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen ... Vogel W, Gish GD, Alves F, Pawson T (Dec 1997). "The discoidin domain receptor tyrosine kinases are activated by collagen". ... Mohan RR, Mohan RR, Wilson SE (Jan 2001). "Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase ...
Using type I collagen nanofibers produced via electrospinning, Shih et al. found that the engineered collagen scaffold showed ... Shih YR, Chen CN, Tsai SW, Wang YJ, Lee OK (November 2006). "Growth of mesenchymal stem cells on electrospun type I collagen ... Nonmineralized organic component (i.e. type 1 collagen), mineralized inorganic component (i.e. hydroxyapatite), and many other ... PCL is a type of biodegradable polyester that can be prepared via ring-opening polymerization of ε-caprolactone using catalysts ...
Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ... integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. 276 (31): 29368-74. doi:10.1074/jbc. ... They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. ... Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells. The DX5 monoclonal ...
Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ... 1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI". Exp ... 1996). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 ... MacDonald TT, Horton MA, Choy MY, Richman PI (1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium ...
Cleaves type IV collagen at Ala73-Gln in alpha1(IV) and at Gly7-Leu in alpha2(IV) This endopeptidase is present in the venom of ... "Identification of the cleavage sites by a hemorrhagic metalloproteinase in type IV collagen". Matrix. 10 (2): 91-7. doi:10.1016 ... 22 (16): 3770-8. doi:10.1021/bi00285a009. PMID 6351911. Baramova EN, Shannon JD, Bjarnason JB, Fox JW (May 1990). " ...
... with type IV collagen. J Biol Chem 1990; 265:17281-4. Paralkar VM, Vukicevic S, Reddi AH. Transforming growth factor beta type ... Transitions in collagen types during matrix-induced cartilage, bone, and bone marrow formation. Proc Natl Acad Sci U S A 1977; ... potentiation and binding to type IV collagen. J Cell Biol 1992; 119:1721-8. Ripamonti U, Ma S, Cunningham NS, Yeates L, Reddi ... Ramachandran, G.N., Reddi, A.H. (Eds.), Biochemistry of Collagen. Plenum Press, New York, NY, 1976. Piez, K.A., Reddi, A.H. ( ...
Immunohistochemical staining of basement membranes of kidney for laminin, collagen type IV, fibronectin, and Goodpasture ... "Regulation of collagen type IV genes is organ-specific: Evidence from a canine model of Alport syndrome". Kidney International ... X-linked hereditary nephritis resulting from a single base mutation in the gene encoding the alpha 5 chain of collagen type IV ... 42 (5): 235-8. doi:10.1111/j.1748-5827.2001.tb02027.x. PMID 11380016. Zheng, Keqin; Perry, Julie; Harvey, Scott J; Sado, ...
Assouti M, Vynios DH, Anagnostides ST, Papadopoulos G, Georgakopoulos CD, Gartaganis SP (Jan 2006). "Collagen type IX and HNK-1 ... 7 (4): 353-8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. Tone Y, Kitagawa H, Imiya K, Oka S, Kawasaki T, Sugahara K (Oct ... 10 (5): 1443-8. doi:10.3892/or.10.5.1443. PMID 12883721. Kakuda S, Shiba T, Ishiguro M, Tagawa H, Oka S, Kajihara Y, Kawasaki T ... 8 (7): 654-63. doi:10.1038/sj.mp.4001382. PMID 12874601. Chochi K, Ichikura T, Majima T, Kawabata T, Matsumoto A, Sugasawa H, ...
Each type of connective tissue in animals has a type of ECM: collagen fibers and bone mineral comprise the ECM of bone tissue; ... Facit (Type IX, XII, XIV). *Short chain (Type VIII, X). *Basement membrane (Type IV) ... Collagen[edit]. Collagens are the most abundant protein in the ECM. In fact, collagen is the most abundant protein in the human ... The collagen can be divided into several families according to the types of structure they form: *Fibrillar (Type I, II, III, V ...
In addition, the encoded protein can bind the promoter and upstream element and stimulate the expression of the collagen type I ... "Tumor Necrosis Factor Alpha Inhibits Type I Collagen Synthesis through Repressive CCAAT/Enhancer-Binding Proteins". Mol. Cell. ... CEBP-beta is critical for normal macrophage functioning, an important immune cell sub-type; mice unable to express CEBP-beta ... 20 (3): 912-8. doi:10.1128/MCB.20.3.912-918.2000. PMC 85208. PMID 10629048. Tanaka T, Uchiumi T, Hinoshita E, Inokuchi A, Toh S ...
It is composed of different kinds of collagen (Type IV and VIII) than the stroma. The endothelial layer is located at the ... "Tissue Distribution of Type VIII Collagen in Human Adult and Fetal Eyes" (PDF). Investigative Ophthalmology and Visual Science ... Its thickness ranges from 3 μm at birth to 8-10 μm in adults. The corneal endothelium is a single layer of squamous cells ...
Collagen is exposed at the site of injury, the collagen promotes platelets to adhere to the injury site. Platelets release ... TypesEdit. Hemostasis can be achieved in various other ways if the body cannot do it naturally (or needs help) during surgery ... Some main types of hemostasis used in emergency medicine include: *Chemical/topical- This is a topical agent often used in ... Which hemostasis type used is determined based on the situation.[8]. Developmental Haemostasis refers to the differences in the ...
... and types I and III collagen". J. Biol. Chem. 277 (13): 10783-8. doi:10.1074/jbc.M110992200. PMID 11788595. Dokras A, Gardner ... Biliran H, Sheng S (2002). "Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous ... 297 (1): 125-8. doi:10.1016/S0006-291X(02)02136-8. PMID 12220518. Sood AK, Fletcher MS, Gruman LM, et al. (2002). "The ... 8 (9): 2924-32. PMID 12231537. Son HJ, Sohn TS, Song SY, et al. (2003). "Maspin expression in human gastric adenocarcinoma". ...
"C-propeptide region of human pro alpha 1 type 1 collagen interacts with thioredoxin". Biochemical and Biophysical Research ... Plants have an unusually complex complement of Trxs composed of six well-defined types (Trxs f, m, x, y, h, and o) that reside ... 274 (5): 3182-8. doi:10.1074/jbc.274.5.3182. PMID 9915858.. *^ Li X, Luo Y, Yu L, Lin Y, Luo D, Zhang H, He Y, Kim YO, Kim Y, ... 8 (3): 757-64. doi:10.1002/j.1460-2075.1989.tb03436.x. PMC 400872. PMID 2785919.. ...
Type II collagen can help distinguish it from other tumours. Ferri, Fred (2019). Ferri's clinical advisor 2019 : 5 books in 1. ... The other type of sarcoma is a soft-tissue sarcoma. There are three main types of bone sarcoma based on tissue type - an ... Müller S, Söder S, Oliveira AM, Inwards CY, Aigner T (August 2005). "Type II collagen as specific marker for mesenchymal ... It is the most common type found in adults. Unlike the other types it is rarely found in those under the age of twenty. Most ...
There are at least eight main types, with type I being the least severe and type II the most severe. Diagnosis is often based ... Type IIC demonstrates thin and longer long bones with thin and beaded ribs. Collagen improperly formed, enough collagen is made ... Mutations in the gene CRTAP causes this type. OI caused by mutation in the gene LEPRE1 is classified as type VIII. Type IX ... There are at least nine different types of OI. Type I is the most common. Symptoms vary from person to person. Collagen is of ...
Unlike EC, interstitial collagenase, this enzyme cleaves type III collagen more slowly than type I This enzyme belongs ... Collagenase Hasty KA, Jeffrey JJ, Hibbs MS, Welgus HG (July 1987). "The collagen substrate specificity of human neutrophil ... This enzyme catalyses the following chemical reaction Cleavage of interstitial collagens in the triple helical domain. ... Neutrophil collagenase (EC, matrix metalloproteinase 8, PMNL collagenase, MMP-8) is an enzyme. ...
II and III collagens. In cancer, loss of MMP-8 in the murine MMTV-PyMT breast cancer model has been associated with increased ... is a collagen cleaving enzyme which is present in the connective tissue of most mammals. In humans, the MMP-8 protein is ... 77 (12): 2731-8. doi:10.1182/blood.V77.12.2731.2731. PMID 1646048. Bläser J, Knäuper V, Osthues A, et al. (1992). "Mercurial ... 371 (8): 733-734. doi:10.1515/bchm3.1990.371.2.733. PMID 2169766. Mallya SK, Mookhtiar KA, Gao Y, et al. (1991). " ...
"A novel designer natriuretic peptide CD-NP suppresses TGF-beta 1 induced collagen type I production in human cardiac ... Regulation of fibrillar collagen mRNAs and expression of early transcription factors". Circulation Research. 69 (2): 483-90. ... Bonnin CM, Sparrow MP, Taylor RR (November 1981). "Collagen synthesis and content in right ventricular hypertrophy in the dog ... Weber KT (June 1989). "Cardiac interstitium in health and disease: the fibrillar collagen network". Journal of the American ...
... and type III collagen is largely replaced by type I. Collagen which was originally disorganized is cross-linked and aligned ... They begin to produce the much stronger type I collagen. Some of the fibroblasts mature into myofibroblasts which contain the ... Fibroblasts quickly produce abundant type III collagen, which fills the defect left by an open wound. Granulation tissue moves ... In order for an injury to be healed by regeneration, the cell type that was destroyed must be able to replicate. Cells also ...
... collagen type I, and that it interacts with the "d" and "e" bands of fibrils of this collagen. Decorin appears to influence ... This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. ... Decorin has been shown to interact with: Collagen type I Epidermal growth factor receptor and TGF beta 1, TLR2, and TLR4. ... "Decorin core protein fragment Leu155-Val260 interacts with TGF-beta but does not compete for decorin binding to type I collagen ...
"Decorin core protein fragment Leu155-Val260 interacts with TGF-beta but does not compete for decorin binding to type I collagen ... Ebner R, Chen RH, Lawler S, Zioncheck T, Derynck R (November 1993). "Determination of type I receptor specificity by the type ... However, as with other cell types, TGF-β1 can also have the opposite effect on cells of myeloid origin. For example, TGF-β1 ... TGF-β1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or ...
"Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix ... S1PR1 is also involved in other types of cancer: fibrosarcoma cells migrate upon activation of S1PR1 by S1P via RAC1-CDC42 ... "Src-dependent phosphorylation of membrane type I matrix metalloproteinase on cytoplasmic tyrosine 573: role in endothelial and ... 114 (8): 1082-9. doi:10.1172/JCI22716. PMC 522258. PMID 15489955. Fisher KE, Pop A, Koh W, Anthis NJ, Saunders WB, Davis GE ( ...
The main substrates of the gelatinases are type IV collagen and gelatin, and these enzymes are distinguished by the presence of ... All six membrane-type MMPs (No. 14, No. 15, No. 16, No. 17, No. 24, and No. 25) have a furin cleavage site in the pro-peptide, ... These collagens are the major components of bone, cartilage and dentin, and MMPs are the only known mammalian enzymes capable ... 14 has also been shown to cleave fibrillar collagen, and there is evidence that No. 2 is capable of collagenolysis. In MeSH, ...
Shaffer has type four osteogenesis imperfecta, a condition involving a defect in type 1 collagen, which causes fragile bones ... October 8, 2010. Archived from the original on March 3, 2016. Retrieved September 19, 2015. Giardina, Carolyn; Zakarin, Jordan ... Cericola, Rachel (January 8, 2013). "5 Questions With Frankenweenie Actor Atticus Shaffer". Wired. Retrieved January 14, 2019. ... and short stature; he is 4' 8" (142 cm) tall. Shaffer is a devout Christian, and has a daily Bible study with his mother, ...
There was a great need for fast tissue-typing techniques and the work was performed in collaboration with the biotechnology ... Differences in monocyte phenotypes induced by cultivation on glass or on collagen". Journal of Experimental Medicine. 156 (4): ... Together with Professor Frode Vartdal, Gaudernack contributed to the development of cell-isolation systems for tissue-typing ... Chiarandini, DJ; Stefani, E (1979). "Electrophysiological identification of two types of fibres in rat extraocular muscles". ...
Several types of catenins work with N-cadherins to play an important role in learning and memory (For full article, see ... Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR (October 2011). "A role for collagen XXIII in cancer cell ... For instance, higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened ... levels of collagen helped facilitate adhesions and anchorage-independent cell growth and provided evidence of collagen XXIII's ...
Atrophic acne scars have lost collagen from the healing response and are the most common type of acne scar (account for ... viii-ix. doi:10.1016/j.det.2011.09.001. PMID 22117871.. ... Ablative lasers (such as CO2 and fractional types) have also ... microspheres with collagen; human and bovine collagen derivatives, and fat harvested from the person's own body (autologous fat ... Many over-the-counter treatments in many forms are available, which are often known as cosmeceuticals.[168] Certain types of ...
collagen-containing extracellular matrix. Biological process. • positive regulation of inflammatory response. • positive ... positive regulation of type IV hypersensitivity. • positive regulation of transcription, DNA-templated. • humoral immune ... 74 (4): 760-8. doi:10.1095/biolreprod.105.047522. PMID 16407501.. *. Chamberlin ME, Dean J (1990). "Human homolog of the mouse ... 28 (3): 381-8. doi:10.2164/jandrol.106.001289. PMID 17192598.. *. Qi H, Williams Z, Wassarman PM (2002). "Secretion and ...
List of human cell types derived from the germ layers. References[edit]. *^ .mw-parser-output cite.citation{font-style:inherit ... doi:10.1016/S0168-9525(03)00176-8. PMID 12902164.. *^ a b Tate, Melissa L Knothe; Thomas D. Falls; Sarah H McBride; Radhika ... COL2A1 collagen disease. *Achondrogenesis *type 2. *Hypochondrogenesis. SLC26A2 sulfation defect. *Achondrogenesis *type 1B ... 5 (8): e1000616. doi:10.1371/journal.pgen.1000616. PMC 2721633. PMID 19696890.. ...
... the rate of collagen loss will be accelerated and extreme pH can cause collagen swelling and accelerated hydrolysis.[8] Due to ... The study of diagenesis in rocks is used to understand the geologic history they have undergone and the nature and type of ... The composite nature of bone, comprising one-third organic (mainly protein collagen) and two thirds mineral (calcium phosphate ... The hydrolytic activity plays a key role in the mineral phase transformations that exposes the collagen to accelerated chemical ...
Type I collagen is present in many forms of connective tissue, and makes up about 25% of the total protein content of the ... Type I Collagen". Journal of Biological Chemistry. 277 (6): 4223-31. doi:10.1074/jbc.M110709200. PMID 11704682.. ... TypesEdit. Connective tissue can be broadly subdivided into connective tissue proper, and special connective tissue.[5][6] ... groups of adipose cells are kept together by collagen fibers and collagen sheets in order to keep fat tissue under compression ...
10% of all dislocations are anterior and this is broken down into superior and inferior types.[32] Superior dislocations ... syndrome is genetically inherited disorder that is thought to affect the encoding of the connective tissue protein's collagen ... the most common type of shoulder dislocation (96-98% of the time) occurs when the arm is in external rotation and abduction ( ... 83(8): 1119-1124. *^ Warby, Sarah A.; Pizzari, Tania; Ford, Jon J.; Hahne, Andrew J.; Watson, Lyn (2014-01-01). "The effect of ...
Both types of plants occur in tropical areas, but only C3 plants occur naturally in colder areas. 12C and 13C occur in a ratio ... Based on stable isotope levels, eight Cobern Street Burial Ground individuals consumed a diet based on C4 (tropical) plants in ... Nitrogen isotopes in bone collagen are ultimately derived from dietary protein, while carbon can be contributed by protein, ... This references the variety of types of labor (e.g., domestic vs. carrying heavy loads) labor that enslaved individuals were ...
Possibly important to basement membrane architecture and tissue development, as a needed catalyst to make collagen IV.[37] ... "Retrieved November 8, 2011.. *^ Corbridge, D. E. C. (1995-02-01). Phosphorus: An Outline of Its Chemistry, Biochemistry, and ... 527-8. ISBN 1-133-10405-3. Retrieved 10 July 2016.. *^ "Chromium". Office of Dietary Supplements, US National Institutes of ... ISBN 978-1-4665-0572-8. Retrieved 3 July 2016.. *^ Harris, Ph.D., Edward D. (1 January 2014). Minerals in Food Nutrition, ...
Data also proposed a decrease in weight gain as a result of increased consumption lessens the risk of developing diabetes type ... Foundation for strong healthy bones and teeth - majority of the calcium consumed as a child is deposited onto collagen bone ... In 2007, only 22% and 61% of four- to eight-year-old children were meeting these recommendations. School-based lunch times ... Vitamin A ensures sufficient collagen is produced to build strong healthy bones and other connecting tissues (Deen & Hark, 2007 ...
Based on this, eight types of secondary structure are assigned. The 310 helix, α helix and π helix have symbols G, H and I and ... is at least 70°), and a blank (or space) is used if no other rule applies, referring to loops.[3] These eight types are usually ... Two types of beta sheet structures exist; a beta bridge has symbol B while longer sets of hydrogen bonds and beta bulges have ...
Type. Appearance (micrograph). Appearance (illustration). Approx. %. in adults. See also:. Blood values. Diameter (μm)[7]. Main ... It rises in response to allergies, parasitic infections, collagen diseases, and disease of the spleen and central nervous ... This type of white blood cell decreased is usually the neutrophil. In this case the decrease may be called neutropenia or ... Types of white blood cells can be classified in standard ways. Two pairs of broadest categories classify them either by ...
There are two types of alveolar epithelial cells - Type 1 pneumocytes represent 90% of the cell surface area, and are easily ... Mice that survive this initial onslaught go on to demonstrate an increase in lung collagen content, and decreased lung ... Type 2 pneumocytes are more resistant to damage, which is important as these cells produce surfactant, transport ions and ... Depending on the type and amount of irritant gas inhaled, victims can experience symptoms ranging from minor respiratory ...
... of which is collagen type 1 and the remaining 10% ground substance, which includes dentine-specific proteins), and 10% water ( ... TypesEdit. There are three types of dentin, primary, secondary and tertiary.[13][14] Secondary dentin is a layer of dentin ... It is of two types, either reactionary, where dentin is formed from a pre-existing odontoblast, or reparative, where newly ... It is unmineralized and consists of collagen, glycoproteins and proteoglycans. It is similar to osteoid in bone and is thickest ...
Types[edit]. General[edit]. Irwin Fridovich and Joe McCord at Duke University discovered the enzymatic activity of superoxide ... insights into heparin and collagen binding". J. Mol. Biol. 388 (2): 310-26. doi:10.1016/j.jmb.2009.03.026. PMID 19289127.. ... Fe and Mn types (which bind either iron or manganese), and the Ni type (which binds nickel). ... In wild-type S. cerevisiae, DNA damage rates increased 3-fold with age, but more than 5-fold in mutants deleted for either the ...
collagen trimer. • proteinaceous extracellular matrix. • extracellular region. • extracellular exosome. • extracellular space. ... 278 (8): 6160-7. doi:10.1074/jbc.M208322200. PMID 12456677.. *. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). " ... 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.. *. Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). " ...
... organelles which are present in many cellular types throughout the human body. The cilia defects adversely affect "numerous ... Retrieved November 8, 2010.. *^ Ruiz-Perez VL, Ide SE, Strom TM, et al. (2000). "Mutations in a new gene in Ellis-van Creveld ... is a rare genetic disorder of the skeletal dysplasia type. ... COL2A1 collagen disease. *Achondrogenesis *type 2. * ... The disorder was described by Richard W. B. Ellis (1902-1966) of Edinburgh and Simon van Creveld (1895-1971) of Amsterdam.[8] ...
... as healthy collagen replaces the defective collagen with vitamin C repletion. Treatment can be orally or by intramuscular or ... Yamada H, Yamada K, Waki M, Umegaki K (October 2004). "Lymphocyte and plasma vitamin C levels in type 2 diabetic patients with ... six to eight months were required, possibly due to the pre-loading of this group with a 70 mg/day supplement for six weeks ... including wound healing and collagen synthesis. In humans, vitamin C deficiency leads to impaired collagen synthesis, ...
Work at the Institute for Cell Biology, University of Bonn, showed that a certain type of autophagy, i.e., chaperone-assisted ... Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... 38 (8): 1098-103. doi:10.1248/bpb.b15-00096. PMID 26235572.. *^ a b c Mizushima, Noboru; Yoshimori, Tamotsu; Ohsumi, Yoshinori ... CMA is significantly different from other types of autophagy because it translocates protein material in a one by one manner, ...
Two types of PDGFRs have been identified: alpha-type and beta-type PDGFRs.[8] The alpha type binds to PDGF-AA, PDGF-BB and PDGF ... The addition of PDGF at specific time‐points has been shown to stabilise vasculature in collagen‐glycosaminoglycan scaffolds.[ ... Types and classification[edit]. There are five different isoforms of PDGF that activate cellular response through two different ... The receptor for PDGF, PDGFR is classified as a receptor tyrosine kinase (RTK), a type of cell surface receptor. ...
The three main types of hyaluronidases are two classes of eukaryotic endoglycosidase hydrolases and a prokaryotic lyase-type of ... "Testicular hyaluronidase induces tubular structures of endothelial cells grown in three-dimensional collagen gel through a CD44 ... 8] a form of subcutaneous immunoglobulin (SCIG) that uses Hylenex to allow for a far greater volume of SCIG to be administered ... 74 (1): 40-8. doi:10.1128/IAI.74.1.40-48.2006. PMC 1346594. PMID 16368955.. ...
TNF can bind two receptors, TNFR1 (TNF receptor type 1; CD120a; p55/60) and TNFR2 (TNF receptor type 2; CD120b; p75/80). TNFR1 ... Tumor necrosis factor (TNF) alpha increases collagen accuulation and proliferation in intestinal myofibrobasts via TNF Receptor ... TNF is primarily produced as a 233-amino acid-long type II transmembrane protein arranged in stable homotrimers.[24][25] From ... TNF was thought to be produced primarily by macrophages,[36] but it is produced also by a broad variety of cell types including ...
Work at the Institute for Cell Biology, University of Bonn, showed that a certain type of autophagy, i.e., chaperone-assisted ... Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... There are three main types of autophagy (macroautophagy, microautophagy and Chaperone mediated autophagy), these are mediated ... 38 (8): 1098-103. doi:10.1248/bpb.b15-00096. PMID 26235572.. *^ a b c Mizushima N, Yoshimori T, Ohsumi Y (10 November 2011). " ...
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C- ... Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen".[citation needed] Collagen IV ... type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 ... Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase?". Alcoholism: ...
Saad, Mohamed (Oct 1994). Low resolution structure and packing investigations of collagen crystalline domains in tendon using ... Kraft and sulfite (also called sulphite) refer to the type of pulping process used to remove the lignin bonding the original ... Instances are collagen[3] family of proteins, tendon, muscle proteins like actin, cell proteins like microtubules and many ... ISBN 0-13-017440-8. *^ James Edward Gordon; Philip Ball (2006). The new science of strong materials, or, Why you don't fall ...
After CGPD resolves, the skin may return to normal without scarring or may have small atrophic depressions with collagen loss, ... Gianotti-type perioral dermatitis or Facial Afro-Caribbean childhood eruption Specialty. Dermatology. ... "Annals of Dermatology (Review). 23 (3): 386-8. doi:10.5021/ad.2011.23.3.386. PMC 3162274. PMID 21909215.. ... Tetracycline antibiotics are not recommended for children under the age of 8 since tetracyclines are known to deposit in teeth ...
Collagen cross-linking by applying riboflavin topically then shining UV light is a method to slow progression of corneal ... One such organism is Micrococcus luteus (American Type Culture Collection strain number ATCC 49442), which develops a yellow ... Retrieved 8 December 2016.. *^ a b Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones ... Retrieved 8 December 2016.. *^ Board, NIIR (2012). The Complete Technology Book on Dairy & Poultry Industries With Farming and ...
Platelet activation (through agonists such as thrombin, Type II collagen and ADP) results in "membrane flipping" where the ... The extracellular region of P-selectin is composed of three different domains like other selectin types; a C-type lectin-like ... a type of glycosaminoglycan (GAG). Its activity in tumor metastasis has been probed by the addition of heparin that functions ... 7 (8): 1277-84. doi:10.1093/hmg/7.8.1277. PMID 9668170.. *^ Pan J, Xia L, McEver RP (April 1998). "Comparison of promoters for ...
ANA type. Target antigen. Sensitivity (%) SLE. Drug-induced LE. Diffuse systemic sclerosis. Limited systemic scleroderma. ... collagen IV, fibronectin and laminin. Binding to these antigens within the kidney could cause inflammation and complement ... There are ten proteins in this complex and antibodies to eight of them are found at varying frequencies; PM/Scl-100 (70-80%), ... Some ANAs appear in several types of disease, resulting in lower specificity of the test. For example, IgM-rheumatoid factor ( ...
"Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen" ... 8] முகிழ்கருவின் நார்க்குருத்துக் கலங்களில் இருந்து தான் சில இணைப்பிழையங்கள் உருவாகின்றன. முதல்வகைப் பிசின்மம் பல வடிவ ...
"Entrez Gene: COL8A1 collagen, type VIII, alpha 1". Shuttleworth CA (1998). "Type VIII collagen". Int. J. Biochem. Cell Biol. 29 ... Illidge C, Kielty C, Shuttleworth A (1998). "The alpha1(VIII) and alpha2(VIII) chains of type VIII collagen can form stable ... This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major ... Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ...
"Entrez Gene: COL8A2 collagen, type VIII, alpha 2". Shuttleworth CA (1998). "Type VIII collagen". Int. J. Biochem. Cell Biol. 29 ... Illidge C, Kielty C, Shuttleworth A (1998). "The alpha1(VIII) and alpha2(VIII) chains of type VIII collagen can form stable ... 1991). "The alpha 2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome 1". ... Greenhill NS, Rüger BM, Hasan Q, Davis PF (2000). "The alpha1(VIII) and alpha2(VIII) collagen chains form two distinct ...
J:35224 Iruela-Arispe ML, et al., Expression of type VIII collagen during morphogenesis of the chicken and mouse heart. Dev ... Blue cells = expressed in wild-type.. Gray triangles = other expression annotations only. (e.g. absence of expression or data ...
VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to ... A collagen heterotrimer containing type VIII alpha chains; [alpha1( ... Collagen type VIII expression in human diabetic nephropathy. * Efficient Generation of Human Embryonic Stem Cell-Derived ... Maternal exposure to carbon black nanoparticle increases collagen type VIII expression in the kidney… ...
Collagen degradation (Homo sapiens) * Collagen type VIII degradation by ELANE (Homo sapiens) * Collagen type VIII fibril [ ... Collagen type VIII degradation by MMP1 (Homo sapiens) * Collagen type VIII fibril [extracellular region] (Homo sapiens) ... Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Homo sapiens) * Collagen type VIII fibril [extracellular ... Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Homo sapiens) * Collagen type VIII fibril [extracellular ...
... has enzymatic activity against native type I collagen, and the activity was inhibited by EDTA, 1,10- … ... tMMP-8) lacking a portion of the carboxy terminus and with an intact aminoterminus (latent; l-tMMP-8) or a truncated amino ... Background/aims: Excess type I collagen accumulation is a major feature of fibrotic diseases such as liver cirrhosis. Reversion ... being the most active against type I collagen. Introduction of MMP-8 gene into liver cells could be an advantageous tool to ...
Aubrey Organics, Body Lotion, Collagen & Almond, All Skin Types, 8 fl oz (237 ml) 93 Reviews ... Aubrey Organics, Body Lotion, Collagen & Almond, All Skin Types, 8 fl oz (237 ml). By. Aubrey Organics. ... Aubrey Organics, Body Lotion, Collagen & Almond, All Skin Types, 8 fl oz (237 ml). By. Aubrey Organics. ... Aubrey Organics, Body Lotion, Collagen & Almond, All Skin Types, 8 fl oz (237 ml). By Aubrey Organics ...
VIII) chain of type VIII collagen, have previously been described in patients with both FECD and PPCD,4,5 and type … ... Exclusion of COL8A1, the gene encoding the α2(VIII) chain of type VIII collagen, as a candidate for Fuchs endothelial dystrophy ... Exclusion of COL8A1, the gene encoding the α2(VIII) chain of type VIII collagen, as a candidate for Fuchs endothelial dystrophy ...
Efficacy and Safety of Riboflavin-Ultraviolet Type A Rays Inducing Cross-Linking of Corneal Collagen in Patients Aged 8 to 16 ... Efficacy and Safety of Riboflavin-Ultraviolet Type A Rays Inducing Cross-Linking of Corneal Collagen in Patients Aged 8 to 16 ... Efficacy and Safety of Riboflavin-Ultraviolet Type A Rays Inducing Cross-Linking of Corneal Collagen in Patients Aged 8 to 16 ... Purpose : To assess the effectiveness and safety of riboflavin-ultraviolet type A (UVA) rays induced cross-linking (CXL) of ...
These studies indicate that the dye and light treatment of insoluble Type I collagen (1) results in cross-linking of collagen ... Insoluble Type I collagen from bovine Achilles tendon (Sigma C9879) was suspended in a 3 mM solution of the dye diEd66Br ... Gel electrophoretic studies of photochemical cross-linking of type I collagen with brominated 1,8-naphthalimide dyes and ... Following pelleting of the collagen by centrifugation and 3x washing in phosphate-buffered saline, aliquots of light-treated ...
Anti-type II collagen antibodies, anti-CCP, IgA RF and IgM RF are associated with joint damage, assessed eight years after ... Background: Early appearance of antibodies specific for native human type II collagen (anti-CII) characterizes an ... Keywords: Arthritis, Juvenile Idiopathic Arthritis, Anti-CCP, Rheumatoid factor, Anti-collagen type II antibodies, ... assessed after eight years of disease. The role of anti-CII in JIA should be further studied. ...
Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 Stable Identifier ... Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Bos taurus) ... Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Bos taurus) ... Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens) ...
... that did not react with the anti-type VIII collagen IgG. Type VIII collagen therefore appears to be synthesized as a ... that did not react with the anti-type VIII collagen IgG. Type VIII collagen therefore appears to be synthesized as a ... that did not react with the anti-type VIII collagen IgG. Type VIII collagen therefore appears to be synthesized as a ... that did not react with the anti-type VIII collagen IgG. Type VIII collagen therefore appears to be synthesized as a ...
Recombinant Collagen Type VIII Alpha 1 (COL8a1), Cat#RPU40909. Write a Review Write a Review. × ... Recombinant Collagen Type VIII Alpha 1 (COL8a1), Cat#RPU40909. Rating Required Select Rating. 1 star (worst). 2 stars. 3 stars ... Product/Service Type: ELISA Kits. *Immunity, 50(2): 446-461.e9. (2019). PMID: 30709742. Title: Microbiota Sensing by Mincle-Syk ... Product/Service Type: Custom Gene Synthesis Service. *Nature, 577: 689-694. (2020). PMID: 31942068. Title: VEGF-C-driven ...
The collagen fiber network was developed in a representative volume element, which used the inter-fiber spacing to regulate the ... In this work, the role of crosslinks in terms of density and stiffness on the macroscopic behavior of collagen gel were ... Results suggest that the cross-linked fiber alignment dominated the strain stiffening effect of the collagen gel. In addition, ... This work could enhance our understanding of collagen gel mechanics and shed lights on designing future clinical relevant ...
Collagen Type VIII Alpha 2 Chain, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - ... COL8A2 (Collagen Type VIII Alpha 2 Chain) is a Protein Coding gene. Diseases associated with COL8A2 include Corneal Dystrophy, ... This gene encodes the alpha 2 chain of type VIII collagen. This protein is a major component of the basement membrane of the ... Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial ...
This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major ... collagen type VIII alpha 1 chain. Enable Javascript to view the expand/collapse boxes.. Open All Close All ... The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the ...
colocalizes_with collagen-containing extracellular matrix ISS Inferred from Sequence or Structural Similarity. more info ... a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8. ... Gene type. protein coding. RefSeq status. REVIEWED. Organism. Homo sapiens Lineage. Eukaryota; Metazoa; Chordata; Craniata; ... TSP1; Thrombospondin type 1 repeats. cd04273. Location:219 → 426. ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like ...
Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. Here the D is approximately 67 nm and ... These form the most abundant collagens in vertebrates. ... There are 29 genetically distinct collagens present in animal ... VIII. some endothelial cells. COL8A1, COL8A2. Posterior polymorphous corneal dystrophy 2. IX. FACIT collagen, cartilage, assoc ... Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen ...
... and type IV collagen (tissue framework; brown) showed that the number of OX62+BrdU+ cells increased significantly in the spleen ...
The extracellular matrix of the membranes contained collagen types I, III, IV, and V; fibronectin; laminin; mucopolysaccharide ... Primary antisera to c-retinaldehyde-binding protein; leukocyte common antigen; factor VIII-related antigen; S-100 protein; ... Publication type, MeSH terms, Substances. Publication type. *Research Support, Non-U.S. Govt ... collagen types I, II, III, IV, and V; laminin; and fibronectin were used for immunohistochemical characterization of the ...
The purified mass is dried to provide the desired Type I collagen product which may be ground into a powder or formed into a ... The enzyme-treated comminuted material which is rich in collagen is dispersed in an organic acid to cause the fibrillar mass to ... source such as poultry feet that incorporates a fibrillar mass of connective tissue as well as bony tissue to yield a collagen ... collagen matrix or sponge, depending on the end use therefor. ... A process for extracting type I collagen from an avian ...
Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II ... Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol Rev 1990; 118: 193-232.. Direct Link: ... Analysis of type I and IV collagens by FT-IR spectroscopy and imaging for a molecular investigation of skeletal muscle ... Antibodies to type II collagen in early rheumatoid arthritis: correlation with disease progression. Arthritis Rheum 1996; 39: ...
Distribution of type VIII collagen in tissues: an immunohistochemical study. Connect Tissue Res 1990; 24: 303-318.. *CrossRef, ... Type VIII collagen. Int J Biochem Cell Biol 1997; 29: 1145-1148.. *CrossRef, ... The interaction of decorin core protein fragments with type I collagen. Biochem Biophys Res Commun 1992; 189: 165-172.. * ... Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol Prog 1991; 7: 237-245.. ...
This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha ... Collagen, type VII, alpha 1 has been shown to interact with Laminin 5 and Fibronectin. Collagen GRCh38: Ensembl release 89: ... of type VII collagen is amino-terminal and chimeric. Homology to cartilage matrix protein, the type III domains of fibronectin ... "Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin". The ...
Shop for Reviva Labs Elastin Collagen Body Firming Lotion at Kroger. Find quality products to add to your Shopping List or ...
... especially actomyosin and Type I collagen, which is found in muscle joints.[8] ... The specificity of zingibains binding ensures predominant hydrolyzation of actomyosin and Type I collagen. ... Zingibain exhibits complex-type N-linked oligosaccharide chains at two residues.[1] Chains are between 5-13 glycosyl units long ... Zingibain is also used to flavor sausages and baked products.[8] Rennet substitute[edit]. For over the past 100 years, ginger ...
VIII) collagen. Learn about this gene and related health conditions. ... The COL8A2 gene provides instructions for making a component of type VIII collagen called alpha 2( ... VIII) collagen. Type VIII collagen is largely found within the front surface of the eye, called the cornea. Type VIII collagen ... To construct type VIII collagen, one subunit of the alpha 2(VIII) collagen protein interacts with two subunits of another ...
As expected, approximately half of the embryos in these litters (four of eight embryos and three of seven embryos) were P3H2−/− ... Collagens constitute nearly 30% of all proteins in our body (1). Among the 29 collagen types, type IV collagen is a major and ... collagen types I, II, and III) and networks (collagen types IV and VI) (1). Proper posttranslational modifications of collagen ... C and D) Presence of type IV collagen in both P3H2-null and control embryos at E6 (green) is shown. colIV, type IV collagen. (E ...
Anti-idiotypic antibodies against BP-IgG prevent type XVII collagen depletion. Front Immunol. 2017;8:1669.CrossRefPubMed ... Type I and type II Fc receptors regulate innate and adaptive immunity. Nat Immunol. 2014;15(8):707-16.CrossRefPubMedGoogle ... Immunoadsorption against two distinct epitopes on human type XVII collagen abolishes dermal-epidermal separation induced in ... Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs. Proc Natl ...
  • Collagen alpha-1(VIII) chain is a protein that in humans is encoded by the COL8A1 gene. (wikipedia.org)
  • Electrophoretic protein migration in 8% to 25% gradient polyacrylamide gels following SDS solubilization disclosed numerous, densely packed, essentially contiguous protein bands. (spie.org)
  • This protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. (genecards.org)
  • COL8A2 (Collagen Type VIII Alpha 2 Chain) is a Protein Coding gene. (genecards.org)
  • Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. (nih.gov)
  • In the skin, the type VII collagen protein is synthesized by keratinocytes and dermal fibroblasts. (wikipedia.org)
  • To construct type VIII collagen, one subunit of the alpha 2(VIII) collagen protein interacts with two subunits of another protein called alpha 1(VIII) collagen. (medlineplus.gov)
  • The COL8A2 gene mutations that cause the early-onset variant of Fuchs endothelial dystrophy replace single protein building blocks in alpha 2(VIII) collagen. (medlineplus.gov)
  • These mutations impair the structure of alpha 2(VIII) collagen, probably preventing the abnormal protein from being incorporated into type VIII collagen fibers. (medlineplus.gov)
  • Animal hides, a major byproduct of the meat industry, are a rich source of collagen, a structural protein of the extracellular matrix that gives strength and form to the skin, tendons and bones of mammals. (usda.gov)
  • Undernatured Type II Collagen is the principal structural protein in cartilage that is responsible for its tensile strength and toughness. (iherb.com)
  • p>This indicates the type of evidence that supports the existence of the protein. (uniprot.org)
  • Collagen protein is abundantly present in human. (sigmaaldrich.com)
  • These genes each provide instructions for making one component of a protein called type IV collagen. (medlineplus.gov)
  • Mutations in these genes result in abnormalities of the type IV collagen in glomeruli, which prevents the kidneys from properly filtering the blood and allows blood and protein to pass into the urine. (medlineplus.gov)
  • Collagen / ˈ k ɒ l ə dʒ ɪ n / is the main structural protein in the extracellular space in the various connective tissues in animal bodies. (wikipedia.org)
  • We determined concentrations of PICP, ICTP, C-reactive protein (CRP), IL-6, IL-8, and tumor necrosis factor (TNF)-α by using enzyme-linked immunosorbent assay methods. (dovepress.com)
  • [1] ​ ​ Of the 28 different types of collagen that have been identified, type II collagen is the main structural protein in cartilage. (nutraingredients.com)
  • Type VIII collagen molecules, expressed by corneal and vascular endothelial cells, are heterotrimers composed of 2 genetically distinct polypeptides, alpha-1(VIII) (COL8A1) and alpha-2(VIII) (COL8A2). (abcam.com)
  • The COL8A2 gene provides instructions for making a component of type VIII collagen called alpha 2(VIII) collagen. (medlineplus.gov)
  • Immunofluorescence studies with the mAb showed the type VIII collagen was deposited as fibrils in the extracellular matrix of corneal endothelial cells. (elsevier.com)
  • Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. (news-medical.net)
  • Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen respectively. (news-medical.net)
  • The structure of fibrous collagen, a long triple helix that self-associates in a staggered array to form a matrix of fibrils, fibers and fiber bundles, makes it uniquely suitable as a scaffold for biomaterial engineering. (usda.gov)
  • The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. (rcsb.org)
  • Thus, antibodies to these domains should stain fibroblasts synthesizing type I collagen but not extracellular collagen fibrils which could mask the signal from the cells. (jci.org)
  • Recessive dystrophic epidermolysis bullosa (RDEB) is an incurable disease caused by mutations in the gene encoding type VII collagen, the major component of anchoring fibrils (AF). (jci.org)
  • 12 13 Thus, the scenario was suggested that LDL bound to collagen, became oxidized, and would afterwards be taken up by macrophages gliding along collagen fibrils. (ahajournals.org)
  • Collagen consists of amino acids wound together to form triple- helices to form of elongated fibrils . (wikipedia.org)
  • transmembrane collagen, interacts with integrin a1b1, fibronectin and components of basement membranes like nidogen and perlecan. (news-medical.net)
  • Collagen, type VII, alpha 1 has been shown to interact with Laminin 5 and Fibronectin. (wikipedia.org)
  • We investigated the binding of oxidized LDL (ox-LDL) to microtiter plates coated with type I or II collagen, laminin, fibronectin, or poly- d -lysine. (ahajournals.org)
  • Application of the F(ab′) 2 from a monoclonal antibody to ox-LDL revealed a strong competition of the binding of highly ox-LDL to type II collagen (60%), laminin (35%), type I collagen (20%), and poly- d -lysine (15%), whereas the binding to fibronectin was not affected. (ahajournals.org)
  • In addition to these collagen phenotypes and poly- d -lysine, we investigated for the first time the binding of ox-LDL to laminin and fibronectin. (ahajournals.org)
  • 2011. Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage . (cardiff.ac.uk)
  • Collagens constitute nearly 30% of all proteins in our body. (pnas.org)
  • Berg, R. A., Schwartz, M. L., and Crystal, R. G. (1980) Regulation of the production of secretory proteins: intracellular degradation of newly synthesized "defective" collagen. (springer.com)
  • To elucidate the role of extracellular matrix and basement membrane associated proteins at the ectodermal-ectomesenchymal interface of developing salivary glands, human fetal submandibular glands (n=100), gestational age varying from 10 to 40 weeks, were evaluated for expression of tenascin, type IV collagen and laminin by using immunohistochemical methods and the results were compared with their expression in adult glands (n=20). (nii.ac.jp)
  • They're made from proteins such as collagen, and minerals such as calcium. (healthline.com)
  • 9 10 11 The structure of two scavenger receptors, recently explored by cloning cDNA from bovine lung library and designated type I and type II, was found to contain a collagenous domain, which plays a key role in binding chemically modified proteins, such as acetylated LDL, ox-LDL, and maleylated bovine serum albumin. (ahajournals.org)
  • The thrombospondins(TS) are a family of proteins which appear to be involved in the acute regulation of the migration, adhesion and proliferation of a number of cell types. (go.jp)
  • Some serotypes, presence of multiple serotypes and strains with collagen ‐binding proteins (CBP, Cnm and Cbm) have been linked with systemic disease. (medworm.com)
  • According to the U.S. National Institutes of Health, collagens are a family of proteins that are part of body tissues, including skin, cartilage and joints. (frysfood.com)
  • Vitacost Advanced Collagen is made from pure type 1 and type 3 collagen proteins that have undergone enzymatic hydrolysis for reduced molecular weight. (frysfood.com)
  • Finally, a-tMMP-8 cDNA was cloned in a vector under transcriptional control of a regulated promoter (PEPCK-a-tMMP-8). (nih.gov)
  • Determination of the complete cDNA sequence of rat type II collagen and evaluation of distinct expression patterns of types IIA and IIB procollagen mRNAs during fracture repair in rats. (biomedsearch.com)
  • First, we sequenced the rat collagen type II cDNA to design the primers. (biomedsearch.com)
  • 8. The isolated nucleic acid of claim 7 , which is a cDNA. (google.com)
  • IL-8 is represented in 53 dbEST cDNA libraries. (biomedcentral.com)
  • EST sequences in GenBank are derived from cDNA libraries generated from a vast array of tissue types including normal, disease-state, and variously treated tissues. (biomedcentral.com)
  • In the fetal calf, type VII collagen was absent from basement membranes and was found in a limited number of tissues. (elsevier.com)
  • There are 29 genetically distinct collagens present in animal tissues. (news-medical.net)
  • Type I collagen is found throughout the body except in cartilaginous tissues. (news-medical.net)
  • Type II collagen is specific for cartilaginous tissues. (rcsb.org)
  • However, at present there is no simple method for assessing the collagen-synthesizing and secreting activity of fibroblasts in human tissues. (jci.org)
  • The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance between synthesis and degradation. (springer.com)
  • Depending upon the degree of mineralization, collagen tissues may be either rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). (wikipedia.org)
  • Collagen is the main component of connective tissues that make up tendons, ligaments, skin and cartilage. (nutraingredients.com)
  • Although it has many important functions in the body, collagen is best known for its structural role - providing a framework for tissues throughout the body. (nutraingredients.com)
  • Additional analysis suggests that most IL-8 related genes are differentially expressed between non-tumor and tumor tissues. (biomedcentral.com)
  • To focus on IL-8's function in tumor tissues, we further analyzed and ranked the genes in 16 IL-8 related tumor libraries. (biomedcentral.com)
  • IL-8 is also found to be constitutively expressed in several tumor tissues including bronchogenic carcinoma, non-small cell lung cancer, colorectal carcinoma, breast cancer, melanoma, prostate cancer, gastric carcinoma, and ovarian cancer. (biomedcentral.com)
  • Coordinated expression of these and other factors with IL-8 in certain tumor tissues suggests that they may be functionally associated with IL-8 in these tumors. (biomedcentral.com)
  • Type IV collagen and laminin were observed in the basement membrane of salivary ducts and acini beginning from 16-18 weeks, and the intensity of reaction was more prominent during intermediate developing stages (19-32 weeks). (nii.ac.jp)
  • The present study suggests that tenascin forms an epithelial-ectomesenchymal interface before the organization of collagen IV and laminin in the basement membrane of salivary ducts and acini in developing human submandibular glands. (nii.ac.jp)
  • Type VII collagen appears to play a key role in tumor invasion, and appears to operate through association with laminin-5. (stanford.edu)
  • The molecule collagen XVII is closely associated with laminin-5 and a6b4 integrin and also is required for tumor invasion. (stanford.edu)
  • The best model included LAMC2 , encoding laminin-γ2 chain, and COL4A1 , encoding collagen, type IV α1 chain. (aacrjournals.org)
  • We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. (rsc.org)
  • The major components are laminin, type IV collagen, protéoglycan héparan-sulfate and entactin. (sigmaaldrich.com)
  • The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. (wikipedia.org)
  • Collagen VIII is a member of the 'short chain collagen' subfamily, and is a major component of the hexagonal lattice in the Descemet membrane. (abcam.com)
  • An antibody was selected for biochemical and tissue immunofluorescence studies which reacted both with Descemet's membrane and with type VIII collagen 50,000-M(r) polypeptides by competition ELISA and immunoblotting. (elsevier.com)
  • This is the collagen of granulation tissue, and is produced quickly by young fibroblasts before the tougher type I collagen is synthesized. (news-medical.net)
  • A process for extracting type I collagen from an avian source such as poultry feet that incorporates a fibrillar mass of connective tissue as well as bony tissue to yield a collagen product having useful medical and biotechnology applications. (google.co.uk)
  • The enzyme-treated comminuted material which is rich in collagen is dispersed in an organic acid to cause the fibrillar mass to undergo controlled swelling, after which the mass is separated from the bony tissue and purified to remove non-collangenous material. (google.co.uk)
  • Type VIII collagen is a major component of Descemet's membrane, which is a tissue at the back of the cornea. (medlineplus.gov)
  • The absence of staining in normal lung supports the hypothesis that fibrosis is associated with an altered collagen-synthesizing phenotype of tissue fibroblasts. (jci.org)
  • 8-way Joint Formula is a balanced comprehensive joint supplement designed to support healthy connective tissue and joint structure, and maintain joint function and mobility. (jefferspet.com)
  • Binding of LDL to connective tissue of the arterial intima, such as various types of collagen, elastin, and glycosaminoglycans, was found to play an important role in the formation of atherosclerotic lesions. (ahajournals.org)
  • Collagen constitutes one to two percent of muscle tissue and accounts for 6% of the weight of strong, tendinous muscles. (wikipedia.org)
  • Pathology of the collagen underpinning of the heart is understood within the category of connective tissue disease . (wikipedia.org)
  • These studies indicate that the dye and light treatment of insoluble Type I collagen (1) results in cross-linking of collagen molecules and (2) does not denature the trimer conformation sufficiently to enable significant digestion by pepsin. (spie.org)
  • These defects often cause problems in the biosynthesis of the collagen molecules, their assembly and posttranslational modification process that makes them their final end form of collagen. (news-medical.net)
  • Once these molecules are processed, they arrange themselves into long, thin bundles of mature type VIII collagen. (medlineplus.gov)
  • Laminins and collagens are molecules of the extracellular matrix which play particularly crucial roles in epithelial development. (stanford.edu)
  • We have generated transgenic (tg) mice expressing HLA-DQ8αβ (DQA1*0301/DQB*0302) or HLA-DQ6αβ (DQA1*0103/DQB1*0601) molecules lacking endogenous murine class II expression (Aβ0) to investigate the ability of these HLA class II to present type II Collagen (CII) and induce collagen-induced arthritis. (elsevier.com)
  • To examine the interaction of DQ6αβ and DQ8αβ molecules in vivo, we generated double tg DQ6αβ/8αβ (Aβ0) mice expressing both the α- and β-chains of DQ6 and DQ8 molecules by mating DQαβ (Aβ0) and DQ8αβ (Aβ0) tg mice. (elsevier.com)
  • The DQ6αβ/8αβ tg mice provide a model to investigate putative autoantigens and the mechanisms of pathogenesis involved in relapsing polychondritis as well as the influence of the expression of multiple HLA class II molecules on the disease process. (elsevier.com)
  • A pepsin-resistant triple helical domain (chain 50,000 M(r)) of type VIII collagen was isolated from bovine corneal Descemet's membrane and used as an immunogen for the production of mAbs. (elsevier.com)
  • The mAb specifically precipitated a high molecular mass component of type VIII collagen (EC2, of chain 125,000 M(r)) from the culture medium of subconfluent bovine corneal endothelial cels metabolically labeled for 24 h. (elsevier.com)
  • Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2. (genecards.org)
  • Amnion, the collagen-rich layer that forms the load-bearing structure of the fetal membrane, has regenerative capacity and has been used clinically to aid in the healing of various wounds including burns, diabetic ulcers, and corneal injuries. (frontiersin.org)
  • Reviva's Elastin & Collagen Body Firming Lotion improves the appearance of slackened skin during weight loss and may help diminish the appearance of stretch marks. (pennherb.com)
  • Includes powdered Elastin Concentrate and premium Soluble Collagen to soothe skin. (pennherb.com)
  • The type VIII collagen fibril can be either a homo- or a heterotrimer. (wikipedia.org)
  • Type III collagen is found in the walls of arteries and other hollow organs and usually occurs in the same fibril with type I collagen. (news-medical.net)
  • The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. (wikipedia.org)
  • We cloned latent and active MMP-8 genes in prokaryotic and eukaryotic expression vectors and an adenoviral vector. (nih.gov)
  • Vuorio, E. and de Crombrugghe, B. (1990) The family of collagen genes. (springer.com)
  • We report a novel computational approach to identify co-expressed genes using EST database, and its application to IL-8. (biomedcentral.com)
  • This method generated a reference database for genes co-expressed with IL-8 and could facilitate further characterization of functional association among genes. (biomedcentral.com)
  • a-tMMP-8) has enzymatic activity against native type I collagen, and the activity was inhibited by EDTA, 1,10-phenanthroline and TIMP-1. (nih.gov)
  • I'm not new to collagen peptides. (amzn.com)
  • I've been using them for a couple months now with surprising results and I'm a firm believer that collagen peptides have helped my skin look and feel tighter as well as more hydrated. (amzn.com)
  • Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type II. (sigmaaldrich.com)
  • Hydrolysed collagen is manufactured via a specific hydrolysis process, where enzymes "cut" the triple helix molecule into smaller pieces, i.e. short-chain peptides. (nutraingredients.com)
  • This is why hydrolysed collagen is also known as collagen peptides, or denatured type II collagen. (nutraingredients.com)
  • We describe Western immunoblotting of intact α1(I) collagen using antibodies directed to α1(I) collagen amino and carboxyl propeptides. (springer.com)
  • Introduction of MMP-8 gene into liver cells could be an advantageous tool to potentiate fibrosis degradation. (nih.gov)
  • Fitzgerald, J., Lamande, S. R., and Bateman, J. F. (1999) Proteasomal degradation of unassembled mutant type I collagen pro-alpha1(I) chains. (springer.com)
  • Bienkowski, R. S. (1984) Collagen degradation in human lung fibroblasts: extent of degradation, role of lysosomal proteases, and evaluation of an alternate hypothesis. (springer.com)
  • The expression of procollagen 1 C-terminal peptide (PICP) and collagen type 1 C-terminal telopeptide (ICTP), two major by-products in the synthesis and degradation of collagen, was shown to be positively correlated with inflammatory mediator levels in previous studies. (dovepress.com)
  • Experimental evidence suggests that degradation of type IV collagen, and perhaps also perlecan, is the key event in the onset of microvessel damage. (mdpi.com)
  • A nonradioactive assay for type IV collagen degradation. (hopkinsmedicine.org)
  • Only 100% food-grade hydrolyzed collagen is used to ensure superior quality and safety. (frysfood.com)
  • Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. (wikipedia.org)
  • Our bovine type I collagen microfibril model comprises five right-handed triple helices in a left-handed super coil containing gap and overlap regions as well as the nonhelical telopeptides. (usda.gov)
  • ATHLONE, Ireland, March 29, 2017 (GLOBE NEWSWIRE) -- Innocoll Holdings plc (NASDAQ:INNL) ("Innocoll" or the "Company"), a global, commercial-stage, specialty pharmaceutical and medical device company, today announced receipt of formal Type A Meeting minutes from the United States Food and Drug Administration (FDA) relating to its New Drug Application (NDA) for XARACOLL (bupivacaine HCl collagen-matrix implant). (globenewswire.com)
  • 8. The polypeptide fragment of claim 1 wherein the substrate is agarose. (google.es)
  • 9. The polypeptide fragment of claim 1 coupled to collagen. (google.es)
  • In its natural form, collagen has a folded triple helix structure consisting of long polypeptide chains (see figure 1). (nutraingredients.com)
  • Platelet adhesion to collagen type VI was shear rate-dependent and optimal at a rate of 300/s. (ashpublications.org)
  • vWF-dependent adhesion to collagen type III was studied for comparison. (ahajournals.org)
  • Adhesion to glass-coated vWF and vWF-mediated adhesion to collagen type III were in many respects similar. (ahajournals.org)
  • We conclude that adhesion to collagen type III is strongly but not completely determined by the adhesive properties of vWF. (ahajournals.org)
  • Usage information: A monoclonal antibody to the carboxyterminal domain of procollagen type I visualizes collagen-synthesizing fibroblasts. (jci.org)
  • Embryonic chick tendon fibroblasts actively synthesizing type I collagen stained heavily with Anti-pC, while quiescent adult tendon fibroblasts did not stain with Anti-pC. (jci.org)
  • Thus, Anti-pC specifically visualized fibroblasts actively synthesizing collagen. (jci.org)
  • HydroMatrix promotes cell growth and migration and has been shown to support the proliferation of many cell types, including neural stem cells, neurons, glia, astrocytes, fibroblasts, and keratinocytes. (sigmaaldrich.com)
  • The measurement of α1(I) collagen mRNA levels using real-time polymerase chain reaction is then outlined. (springer.com)
  • and (3) type IIB collagen is the predominant mRNA variant expressed at virtually all times during fracture repair. (biomedsearch.com)
  • Recombinant MMP-8 expressed by HepG2-transduced cells can efficiently degrade soluble type I collagen, which is potentially useful for gene transfer therapies. (nih.gov)
  • They enable endothelial cells to attach to underlying extracellular matrix by binding to collagen and they interact with fibrin, heparin, and integrins. (ahajournals.org)
  • This gene encodes the alpha 2 chain of type VIII collagen. (genecards.org)
  • Visit the database of genomic characterization data for multiple tumor types. (nih.gov)
  • This chapter outlines several methods to assess the in vitro production of type I collagen that are employed in our laboratory. (springer.com)
  • 8 On the other hand, ox-LDL was shown in vitro to bind to collagen gels. (ahajournals.org)
  • Type IV collagen is a major and crucial component of basement membranes. (pnas.org)
  • Positional cloning revealed that the shiomaneki (sio) gene locus encodes Col4a6, a subunit of type IV collagen, which, in a complex with Col4a5, is a basement membrane (BM) component. (nih.gov)
  • very late antigen [VLA]-alpha 2 subunit), completely inhibited platelet adhesion to all collagens tested, under conditions of both stasis and flow. (ashpublications.org)
  • An MoAb directed against GPIIa (VLA-beta subunit) partially inhibited platelet adhesion to collagen. (ashpublications.org)
  • Epidermolysis bullosa acquisita involves an autoimmune reaction to this form of collagen. (wikipedia.org)
  • To determine the relationship between Anti-pC staining and collagen synthesis, we stained embryonic and adult chicken tendon. (jci.org)
  • The increased levels of serum PICP in COPD might indicate the condition of airway remodeling, and IL-6 and/or IL-8 might play an important role in stimulating collagen synthesis. (dovepress.com)
  • This gene encodes one of the two alpha chains of type VIII collagen. (wikipedia.org)
  • Collagen chains undergo several posttranslational modifications that are indispensable for proper collagen function. (pnas.org)
  • Zingibain exhibits complex-type N-linked oligosaccharide chains at two residues. (wikipedia.org)
  • Collagen-related diseases most commonly arise from genetic defects or nutritional deficiencies that affect the biosynthesis, assembly, postranslational modification, secretion, or other processes involved in normal collagen production. (news-medical.net)
  • One day Dr. Moore read about some studies on chicken collagen which showed that a small amount taken orally could have a preventive effect on rheumatoid arthritis. (prohealth.com)
  • What Dr. Moore discovered was that, unlike grandma's chicken soup, if he cooked the chicken collagen, it became ineffective. (prohealth.com)
  • not processed by high heat or chemicals) chicken collagen using the chicken's sternum cartilage. (prohealth.com)
  • Derived from chicken sternum cartilage, UC-II is a patented form of Undernatured (native) Type II Collagen that works with the immune system to support healthy joints. (iherb.com)
  • Prolyl 3-hydroxylation is a crucial posttranslational modification of collagens. (pnas.org)
  • Mutations of the gene are linked to posterior polymorphous dystrophy type 2. (wikipedia.org)
  • In the absence of mutations, however, an autoimmune response against type VII collagen can result in an acquired form of this disease called epidermolysis bullosa acquisita. (wikipedia.org)
  • We previously demonstrated that gentamicin produced functional type VII collagen in RDEB cells harboring nonsense mutations. (jci.org)
  • Topical and intradermal gentamicin suppresses nonsense mutations and induces type VII collagen and AFs in RDEB patients. (jci.org)
  • Mutations that disrupt type IV collagen can result in misshapen lenses and an abnormally colored retina. (medlineplus.gov)
  • In addition there is excess collagen formation and deposition in scleroderma. (news-medical.net)
  • In addition to the above mentioned disorders, excessive deposition of collagen occurs in scleroderma. (news-medical.net)
  • Excessive collagen deposition plays a critical role in the development of fibrosis, and early or active fibrosis may be more susceptible to therapeutic intervention than later stages of scarring. (jci.org)
  • Gradual calcium deposition within collagen occurs as a natural function of aging. (wikipedia.org)
  • Will look forward to seeing even more benefits for these collagen capsules. (amzn.com)
  • Prolyl 3-hydroxylation of type IV collagen is required to avoid an aberrant interaction with the platelet-specific glycoprotein VI (GPVI), resulting in platelet aggregation, thrombosis of the maternal blood, and death of the embryo. (pnas.org)
  • The mechanism of the unexpectedly early lethality involves the interaction of non-3-hydroxylated embryonic type IV collagen with the maternal platelet-specific glycoprotein VI (GPVI). (pnas.org)
  • Under normal conditions, subendothelial collagens bear the GPVI-binding sites that initiate platelet aggregation upon blood exposure during injuries. (pnas.org)
  • Thus, prolyl 3-hydroxylation of type IV collagen has an important function preventing maternal platelet aggregation in response to the early developing embryo. (pnas.org)
  • Platelet adhesion to fibrillar collagens (types I, II, III, and V) and nonfibrillar collagens (types IV, VI, VII, and VIII) was investigated in the presence of physiologic concentrations of divalent cations under conditions of stasis and flow. (ashpublications.org)
  • Under static conditions, platelet adhesion was observed to collagen types I through VII but not to type VIII. (ashpublications.org)
  • Under flow conditions, platelet adhesion to collagen types I, II, III, and IV was almost independent of shear rates above 300/s. (ashpublications.org)
  • Collagen types VII and VIII showed minor reactivity and supported platelet adhesion only between shear rates 100 to 1,000/s. (ashpublications.org)
  • The concentration of antibody required for complete inhibition of platelet adhesion was dependent on the shear rate and the reactivity of the collagen. (ashpublications.org)
  • These results show that GPIa-IIa is a major and universal platelet receptor for eight unique types of collagen. (ashpublications.org)
  • In the present study we examined platelet adhesion to purified vWF from flowing blood and compared its characteristics with those of the adhesion of platelets to collagen type III preincubated with vWF. (ahajournals.org)
  • Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. (sigmaaldrich.com)
  • Dr. Eugene Moore, a chemical engineer, had an 8-year-old daughter, Anne Marie, who was diagnosed with rheumatoid arthritis. (prohealth.com)
  • Ten children (8 to 14 years old) with active juvenile rheumatoid arthritis were given UC · II for three months. (prohealth.com)
  • Study population values and correlation analyses between ( A ) serum type IV collagen (ng/ml) versus urine albumin (A:C [μg/mg], r = −0.001) and ( B ) serum type IV collagen versus creatinine (mg/dl) ( r = 0.161). (diabetesjournals.org)
  • In patients with stable COPD, serum levels of CRP, IL-6, IL-8, and TNF-α were all elevated compared to control subjects, but only changes of IL-6 achieved statistical significance. (dovepress.com)
  • Moreover, serum concentrations of PICP were positively correlated with the levels of both IL-6 and IL-8. (dovepress.com)
  • The susceptibility of DQ6αβ/8αβ tg mice compared with resistance in the parental strains suggests that expression of both the DQ6αβ and DQ8αβ tgs, unique to the DQ6αβ8αβ tg strain, is important in susceptibility to experimental polychondritis. (elsevier.com)
  • 1991). "The alpha 2(VIII) collagen gene. (wikipedia.org)
  • Homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. (genecards.org)
  • Two forms of type II collagen, IIA and IIB, are known to be produced by alternative splicing of the Alpha(1) (II) procollagen gene. (biomedsearch.com)
  • The purified mass is dried to provide the desired Type I collagen product which may be ground into a powder or formed into a collagen matrix or sponge, depending on the end use therefor. (google.co.uk)
  • This Collagen Powder was so much bigger than I expected. (evitamins.com)
  • Vitacost Advanced Collagen Types 1 & 3 supplies 6.6 grams of pure, natural collagen in a dissolvable powder that mixes easily with fruit juice for a drinkable supplement. (frysfood.com)
  • Collagen from bovine tracheal cartilage has been used to induce arthritis in male DBA/1 mice. (sigmaaldrich.com)
  • Transfection of MMP-8 in HepG2 was effectuated by CaPO4, polylysine-lactose (P-L) and adenoviral transduction, and cells and culture supernatant were harvested 72 h after transfection for analysis of MMP-8 expression by reverse transcription-polymerase chain reaction and collagenolytic activity. (nih.gov)
  • In contrast, confluent cells in the presence of FCS and isotope for 7 d secreted a collagenous component of chain 60,000 M(r) that did not react with the anti-type VIII collagen IgG. (elsevier.com)
  • Type VIII collagen therefore appears to be synthesized as a discontinuous triple helical molecule with a predominant chain 125,000 M(r) by subconfluent, proliferating cells in culture. (elsevier.com)
  • Among its related pathways are ERK Signaling and Collagen chain trimerization . (genecards.org)
  • Subsequent modeling without these two markers showed that COL1A1 , encoding collagen, type I α1 chain, and PADI1 , encoding peptidyl arginine deiminase, type 1, could also distinguish OSCC from controls. (aacrjournals.org)
  • Structural determination of eight HLA-DR4-self-epitope complexes revealed strict conformational convergence of the P4-Cit and surrounding HLA β-chain residues. (rcsb.org)
  • Type VI collagen promotes lung epithelial cell spreading and wound-closure. (rochester.edu)
  • Type I procollagen carboxyterminal domains are proteolytically removed during collagen secretion. (jci.org)
  • We developed and characterized a monoclonal antibody (Anti-pC) specific for the carboxyterminal propeptide of type I procollagen. (jci.org)