Collagen type viii. Medical search

A non-fibrillar collagen originally found in DESCEMET MEMBRANE. It is expressed in endothelial cell layers and in tissues undergoing active remodeling. It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains.

Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.

A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).

The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.

A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.

An x-linked recessive hepatic glycogen storage disease resulting from lack of expression of phosphorylase-b-kinase activity. Symptoms are relatively mild; hepatomegaly, increased liver glycogen, and decreased leukocyte phosphorylase are present. Liver shrinkage occurs in response to glucagon.

A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.

A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.

A layer of the cornea. It is the basal lamina of the CORNEAL ENDOTHELIUM (from which it is secreted) separating it from the CORNEAL STROMA. It is a homogeneous structure composed of fine collagenous filaments, and slowly increases in thickness with age.

Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy. (1/44)

Corneal clarity is maintained by its endothelium, which functions abnormally in the endothelial dystrophies, leading to corneal opacification. This group of conditions includes Fuchs' endothelial dystrophy of the cornea (FECD), one of the commonest indications for corneal transplantation performed in developed countries, posterior polymorphous dystrophy (PPCD) and the congenital hereditary endothelial dystrophies (CHED). A genome-wide search of a three-generation family with early-onset FECD demonstrated significant linkage with D1S2830 (Z(max) = 3.72, theta = 0.0). Refinement of the critical region defined a 6-7 cM interval of chromosome 1p34.3-p32 within which lies the COL8A2 gene. This encodes the 703 amino acid alpha2 chain of type VIII collagen, a short-chain collagen which is a component of endothelial basement membranes and which represented a strong candidate gene. Analysis of its coding sequence defined a missense mutation (gln455lys) within the triple helical domain of the protein in this family. Mutation analysis in patients with FECD and PPCD demonstrated further missense substitutions in familial and sporadic cases of FECD as well as in a single family with PPCD. This is the first description of the molecular basis of any of the corneal endothelial dystrophies or of mutations in type VIII collagen in association with human disease. This suggests that the underlying pathogenesis of FECD and PPCD may be related to disturbance of the role of type VIII collagen in influencing the terminal differentiation of the neural crest derived corneal endothelial cell. (+info)

Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis. (2/44)

Type VIII collagen is upregulated after vessel injury, and this collagen has been implicated in both smooth muscle cell migration and angiogenesis. This study examines the temporal and spatial pattern of expression of type VIII collagen in porcine coronary vessels at specific time points after balloon angioplasty. In situ hybridization studies demonstrated that collagen VIII messenger ribonucleic acid (mRNA) was markedly elevated in the neoadventitia at 3 days post-angioplasty. By 14 days, elevated collagen VIII message was seen mainly in the neointima and this expression decreased to background levels by 90 days. The distribution of collagen VIII protein, detected using immunohistochemistry, was similar but the up-regulation lagged behind the mRNA increase by a few days. Pre-treatment of sections with pepsin highlighted variations in the organization and appearance of extracellular collagen VIII containing structures in both injured and normal vessels. New vessel formation was evident in the neoadventitia after 3 days, but there was no colocalization of type VIII collagen immunostaining with that of von Willebrand factor (a marker of endothelial cells) in the neoadventitia. These data show that up-regulation of collagen VIII in the neoadventitia is an important early marker of the coronary arterial response to injury, and is not associated with new vessel formation. (+info)

Human corneal epithelial cell viability and morphology after dilute alcohol exposure. (3/44)

PURPOSE: To determine the effect of dilute alcohol on human corneal epithelial cellular morphology and viability. Dilute alcohol is used for epithelial removal during photorefractive keratectomy (PRK) and laser subepithelial keratomileusis (LASEK). METHODS: Corneal epithelial sheets harvested from human eyes after alcohol application during PRK were examined by light and electron microscopy (specimens I-IV). In addition, tissue cultures of human epithelial sheets were monitored for epithelial migration and attachment (specimens V-VII). To determine the effect of dilute alcohol on epithelial cell viability, simian virus (SV)40-immortalized human corneal epithelial cells were exposed to dilute alcohol in distilled water (EtOH-H2O) or to keratinocyte serum-free medium (EtOH-KSFM) for incubation periods of 20 to 45 seconds and concentrations of 10% to 70%. Cell membrane permeability and intracellular esterase activity were analyzed by calcein-acetoxymethyl ester (AM)/ethidium homodimer assay. TdT-mediated dUTP nick-end labeling (TUNEL) assay was used to detect apoptotic cells at 0, 8,12, 24, and 72 hours. RESULTS: Electron microscopy showed varying degrees of basement membrane alterations after alcohol application, including disruptions, discontinuities, irregularities, and duplication (specimens I-IV). Cellular destruction and vacuolization of basal epithelial cells associated with absent basement membrane were also observed (specimen III). One of three cultured epithelial sheets showed attachment and outgrowth in the tissue culture until day 15 (specimen V). Twenty-second exposure of cultured immortalized human cells to various concentrations of EtOH-H2O showed significant reduction of viable cells when EtOH-H2O concentration exceeded 25% (P = 0.005). Increasing the duration of application of 20% EtOH-H2O beyond 30 seconds resulted in a significant reduction in viable cells (69.69% +/- 16.34% at 30 seconds compared with 2.14% +/- 2.29%, 10.45% +/- 7.11%, and 11.09% +/- 15.73% at 35, 40, and 45 seconds, respectively; P = 0.01). TUNEL assay of cultured human corneal epithelial cells exposed to 20% EtOH-H(2)O for 20 and 40 seconds showed maximal labeling at 24 hours (58.05% +/- 33.10%) and 8 hours (94.12% +/- 1.21%), respectively. Exposure to 20% EtOH-KSFM for 20 and 40 seconds resulted in substantially lower TUNEL positivity (3.51% +/- 0.20% at 24 hours and 7.11% +/- 0.49% at 8 hours). CONCLUSIONS: The viability and electron microscopic findings in the basement membrane zone showed significant variation after treatment of the epithelium in vivo with dilute alcohol. The application of dilute alcohol on the monolayer of cultured corneal epithelial cells resulted in increasing cell death in a dose- and time-dependent manner. (+info)

Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. (4/44)

Estrogen exerts a variety of important physiological effects, which have been suggested to be mediated via the two known estrogen receptors (ERs), alpha and beta. Three-month-old ovariectomized mice, lacking one or both of the two estrogen receptors, were given estrogen subcutaneously (2.3 micro g/mouse per day) and the effects on different estrogen-responsive parameters, including skeletal effects, were studied. We found that estrogen increased the cortical bone dimensions in both wild-type (WT) and double ER knockout (DERKO) mice. DNA microarray analysis was performed to characterize this effect on cortical bone and it identified four genes that were regulated by estrogen in both WT and DERKO mice. The effect of estrogen on cortical bone in DERKO mice might either be due to remaining ERalpha activity or represent an ERalpha/ERbeta-independent effect. Other effects of estrogen, such as increased trabecular bone mineral density, thymic atrophy, fat reduction and increased uterine weight, were mainly ERalpha mediated. (+info)

Identification of genes induced in regenerating Xenopus tadpole tails by using the differential display method. (5/44)

To identify candidate gene(s) involved in the tail regeneration of Xenopus laevis tadpoles, we used the differential display method to isolate four genes (clones 1, 2, 13a, and 13b) whose expression is induced in regenerating tadpole tails. Among them, clones 13a and 13b were found to encode the Xenopus homologues of the alpha1 chain of type XVIII collagen and neuronal pentraxin I, respectively. Expression of clone 2 and neuronal pentraxin I genes increased dramatically in the blastema 3 days after amputation, whereas that for the clone 1 and type XVIII collagen genes was induced gradually after amputation. In situ hybridization revealed that the neuronal pentraxin I gene is expressed specifically in the regenerating tail epidermis but not in the normal tail epidermis or the most distal margin of the tail blastema, suggesting that it has a tissue-inductive role in tail regeneration. Expression of the four genes was induced in the limb and in the tail blastema, suggesting that they are involved in the regeneration of both organs. Finally, expression of clone 2 and neuronal pentraxin I genes was scarce during embryonic stages in comparison to the tail blastema, suggesting that their main functions are in organ regeneration. Our results demonstrate unique features of spatial and temporal gene expression patterns during Xenopus tadpole tail regeneration. (+info)

Molecular targets for tumour progression in gastrointestinal stromal tumours. (6/44)

BACKGROUND AND AIMS: The distinction between benign and malignant gastrointestinal stromal tumours (GISTs) is often unclear at the clinical and histopathology levels. GISTs are believed to arise from the stem cells of Cajal. In order to define genetic biomarkers and identify target genes related to GIST progression, we analysed and compared benign and malignant GISTs with verified follow up data using cDNA expression arrays. METHODS: Eight genes were frequently overexpressed in malignant GISTs and their overexpression was confirmed using quantitative real time reverse transcription-polymerase chain reaction. These genes included ezrin (villin 2 (VIL2)), collagen 8 alpha 1 subunit (COL8A1), G2/mitotic specific cyclin B1 (CCNB1), high mobility group protein (HMG2), TSG101 tumour susceptibility protein, CENP-F kinetochore protein, protein tyrosine kinase 2 (FAK), and protein kinase DYRK2. To test these genes in a clinical setting, we obtained diagnostic samples of 16 additional GISTs that were classified at diagnosis as benign, malignant, and uncertain malignant potential (UMP). RESULTS: There was remarkable gene overexpression in all malignant GISTs. Statistical analyses revealed significant correlations between overexpression of several gene pairs in malignant GISTs. We found the strongest correlations (rho>0.70) among the significant correlations (p<0.01) between CCNB1-CENP-F (rho = 0.87) and CCNB1-FAK (rho = 0.73). Gene expression of the UMP GISTs suggested two different groups. Three UMP GISTs had gene expression consistent with malignant tumours and their follow up data revealed that indeed these patients had recurrences later on. On the other hand, UMP GISTs that had low gene expression levels continued free of disease for several years. CONCLUSIONS: These results provide insight into the oncogenesis of GISTs and suggest that testing the expression profile of a number of genes may segregate GISTs into groups of different tumour behaviour. (+info)

Expression and supramolecular assembly of recombinant alpha1(viii) and alpha2(viii) collagen homotrimers. (7/44)

Collagen VIII is an extracellular matrix macromolecule comprising two polypeptide chains, alpha1(VIII) and alpha2(VIII), that can form homotrimers in vitro and in vivo. Here, recombinant collagen VIII was expressed to study its supramolecular assembly following secretion. Cells transfected with alpha1(VIII) or alpha2(VIII) assembled and secreted homotrimers that were stable in denaturing conditions and had a molecular mass of approximately 180 kDa on SDS-PAGE gels. Co-transfection with prolyl 4-hydroxylase generated homotrimers with stable pepsin-resistant triple-helical domains. Size fractionation of native recombinant collagen VIII molecules expressed with or without prolyl 4-hydroxylase identified urea-sensitive high molecular mass assemblies eluting in the void volume of a Superose 6HR 10/30 column and urea-resistant assemblies of approximately 700 kDa, all of which were composed of homotrimers. Immunofluorescence analysis highlighted the extracellular deposition of recombinant alpha1(VIII)(3), alpha2(VIII)(3), and co-expressed alpha1(VIII)(3)/alpha2(VIII)(3). Microscopy analysis of recombinant collagen VIII identified rod-like molecules of 134 nm in length that assembled into angular arrays with branching angles of approximately 114 degrees and extensive networks. Based on these data, we propose a model of collagen VIII assembly in which four homotrimers form a tetrahedron stabilized by central interacting C-terminal NC1 trimers. Tetrahedrons may then act as building blocks of three-dimensional hexagonal lattices generated by secondary interactions involving terminal and helical sequences. (+info)

Endostatin promotes the anabolic program of rabbit chondrocyte. (8/44)

Endostatin is a natural occurred angiogenesis inhibitor derived from collagenXVIII. So far its function during the angiogenesis process of bone formation and arthropathy has not been well studied yet. The present study addresses the function of endostatin in rabbit articular chondrocytes (RAC). We found that endostatin can promote RAC adhesion and spreading as well as its proliferation. In monolayer cultured RAC, CollagenII, TIMP1 and collagenXVIII transcription were up regulated by endostatin while collagenI and MMP9 were down regulated. Moreover collagenXVIII and endostatin antigens are present at synovial fluid. These findings indicate new function of endostatin as a homeostatic factor in cartilage metabolism. (+info)

The symptoms of GSD8 usually become apparent in infancy or early childhood and may include:

1. Hepatomegaly (enlarged liver)
2. Hypoglycemia (low blood sugar)
3. Fatty liver disease
4. Elevated levels of glucose in the urine
5. Delayed development and growth
6. Hypotonia (low muscle tone)
7. Seizures
8. Cognitive impairment
9. Vision loss or blindness
10. Short stature

GSD8 is diagnosed based on a combination of clinical symptoms, laboratory tests, and genetic analysis. Treatment for GSD8 includes a high-carbohydrate diet to manage hypoglycemia and liver disease, as well as medication to control seizures and other symptoms. In some cases, a liver transplant may be necessary.

The prognosis for GSD8 is generally poor, with many individuals experiencing significant developmental delays, intellectual disability, and a shortened life expectancy. However, the outlook can vary depending on the severity of the disease and the presence of any additional medical conditions. With appropriate management and care, some individuals with GSD8 may lead relatively normal lives, while others may require ongoing support and assistance.

"Entrez Gene: COL8A1 collagen, type VIII, alpha 1". Shuttleworth CA (1998). "Type VIII collagen". Int. J. Biochem. Cell Biol. 29 ... Illidge C, Kielty C, Shuttleworth A (1998). "The alpha1(VIII) and alpha2(VIII) chains of type VIII collagen can form stable ... This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major ... Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ...

https://en.wikipedia.org/wiki/Collagen,_type_VIII,_alpha_1

"Entrez Gene: COL8A2 collagen, type VIII, alpha 2". Shuttleworth CA (1998). "Type VIII collagen". Int. J. Biochem. Cell Biol. 29 ... Illidge C, Kielty C, Shuttleworth A (1998). "The alpha1(VIII) and alpha2(VIII) chains of type VIII collagen can form stable ... 1991). "The alpha 2(VIII) collagen gene. A novel member of the short chain collagen family located on the human chromosome 1". ... Greenhill NS, Rüger BM, Hasan Q, Davis PF (2000). "The alpha1(VIII) and alpha2(VIII) collagen chains form two distinct ...

https://en.wikipedia.org/wiki/Collagen,_type_VIII,_alpha_2

The COL11A1 gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a ... collagen cDNA demonstrates that type XI belongs to the fibrillar class of collagens and reveals that the expression of the gene ... "Entrez Gene: COL11A1 collagen, type XI, alpha 1". GeneReviews/NCBI/NIH/UW entry on Stickler Syndrome Yoshioka H, Ramirez F ( ... Keene DR, Oxford JT, Morris NP (1995). "Ultrastructural localization of collagen types II, IX, and XI in the growth plate of ...

https://en.wikipedia.org/wiki/Collagen,_type_XI,_alpha_1

Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, a collagen component of hyaline cartilage. ... "Entrez Gene: COL9A1 collagen, type IX, alpha 1". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...

https://en.wikipedia.org/wiki/Collagen,_type_IX,_alpha_1

"Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen ... "Entrez Gene: COL4A2 collagen, type IV, alpha 2". Hinek A (1995). "Nature and the multiple functions of the 67-kD elastin-/ ... Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another ... This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C- ...

https://en.wikipedia.org/wiki/Collagen,_type_IV,_alpha_2

... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... This gene encodes one of the chains for type I collagen, the fibrillar collagen found in most connective tissues. Mutations in ... Type-I collagen Collagen GRCh38: Ensembl release 89: ENSG00000164692 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... "Entrez Gene: COL1A2 collagen, type I, alpha 2". Byers PH, Wallis GA, Willing MC (1991). "Osteogenesis imperfecta: translation ...

https://en.wikipedia.org/wiki/Collagen,_type_I,_alpha_2

It encodes the alpha chain of type XVII collagen. Collagen XVII is a transmembrane protein, like collagen XIII, XXIII and XXV. ... which in turn causes a type of osteogenesis imperfecta. Collagen, type XVII, alpha 1 has been shown to interact with Keratin 18 ... Collagen XVII is a homotrimer of three alpha1(XVII)-chains and a transmembrane protein in type II orientation. Each 180 kD a- ... 2015). "Mutations in collagen, type XVII, alpha 1 (COL17A1) cause epithelial recurrent erosion dystrophy (ERED)". Hum. Mutat. ...

https://en.wikipedia.org/wiki/Collagen,_type_XVII,_alpha_1

Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. ... "Entrez Gene: COL9A3 collagen, type IX, alpha 3". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...

https://en.wikipedia.org/wiki/Collagen,_type_IX,_alpha_3

"Entrez Gene: COL6A1 collagen, type VI, alpha 1". Bertini E, Pepe G (2002). "Collagen type VI and related disorders: Bethlem ... "Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen". J. Biol. Chem. 272 (42): 26522-9 ... The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that ... 1996). "Type VI collagen mutations in Bethlem myopathy, an autosomal dominant myopathy with contractures". Nat. Genet. 14 (1): ...

https://en.wikipedia.org/wiki/Collagen,_type_VI,_alpha_1

The transcripts for this gene undergo complex and extensive splicing involving at least eight exons. Like other collagens, ... Latvanlehto A, Snellman A, Tu H, Pihlajaniemi T (2003). "Type XIII collagen and some other transmembrane collagens contain two ... Collagen XIII belongs to the transmembranous subfamily of collagens, like collagen XVII, XXIII and XXV. GRCh38: Ensembl release ... 2002). "The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and ...

https://en.wikipedia.org/wiki/Collagen,_type_XIII,_alpha_1

Type XV collagen is known to be a tumor suppressor that can be used to understand tumor cells environment. Type XV collagen ... This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with ... "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed ... Hägg PM, Hägg PO, Peltonen S, Autio-Harmainen H, Pihlajaniemi T (June 1997). "Location of type XV collagen in human tissues and ...

https://en.wikipedia.org/wiki/Collagen,_type_XV,_alpha_1

... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. ... the structure of type I collagen is compromised. Tissues that are rich in type I collagen, such as the skin, bones, and tendons ... Ehlers-Danlos type IV is most attributed to abnormalities in the reticular fibers (collagen Type III). Ehlers-Danlos syndrome, ...

https://en.wikipedia.org/wiki/Collagen,_type_I,_alpha_1

This protein is an alpha chain of type VI collagen that aids in microfibril formation. As part of type VI collagen, this ... This gene encodes the alpha 3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in ... "The 1.6 A structure of Kunitz-type domain from the alpha 3 chain of human type VI collagen". Journal of Molecular Biology. 246 ... "Anisotropic behaviour of the C-terminal Kunitz-type domain of the alpha3 chain of human type VI collagen at atomic resolution ( ...

https://en.wikipedia.org/wiki/Collagen,_type_VI,_alpha_3

... chain of type II collagen. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and ... "A COL2A1 mutation in achondrogenesis type II results in the replacement of type II collagen by type I and III collagens in ... type 2 by affecting tissues that are rich in type II collagen. Platyspondylic lethal skeletal dysplasia, Torrance type:Fewer ... chain that cannot be incorporated into type II collagen fibers. As a result, cells make a reduced amount of type II collagen. ...

https://en.wikipedia.org/wiki/Collagen,_type_II,_alpha_1

"Entrez Gene: COL6A2 collagen, type VI, alpha 2". Bertini E, Pepe G (2002). "Collagen type VI and related disorders: Bethlem ... "Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen". J. Biol. Chem. 272 (42): 26522-9 ... This gene encodes one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective ... 1996). "Type VI collagen mutations in Bethlem myopathy, an autosomal dominant myopathy with contractures". Nat. Genet. 14 (1): ...

https://en.wikipedia.org/wiki/Collagen,_type_VI,_alpha_2

Type XI collagen also helps maintain the spacing and diameter of type II collagen fibrils. Type II collagen is an important ... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... Instead, another type of collagen chain replaces pro-alpha2(XI) to form type XI collagen in the vitreous of the eye. COL11A2 ... The COL11A2 gene produces one component of this type of collagen, called the pro-alpha2(XI) chain. Type XI collagen adds ...

https://en.wikipedia.org/wiki/Collagen,_type_XI,_alpha_2

... as well as in association with tissues containing type I collagen. Autoimmunity against type V collagen is associated with lung ... Type V collagen is a form of fibrillar collagen associated with classical Ehlers-Danlos syndrome. It is found within the dermal ... "Type V collagen controls the initiation of collagen fibril assembly". J. Biol. Chem. 279 (51): 53331-7. doi:10.1074/jbc. ... Collagen+Type+V at the US National Library of Medicine Medical Subject Headings (MeSH) v t e (CS1 errors: missing periodical, ...

https://en.wikipedia.org/wiki/Type_V_collagen

... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... "Entrez Gene: COL5A1 collagen, type V, alpha 1". Mann K (1992). "Isolation of the alpha 3-chain of human type V collagen and ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ...

https://en.wikipedia.org/wiki/Collagen,_type_V,_alpha_1

This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with ... Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to ... "Entrez Gene: COL16A1 collagen, type XVI, alpha 1". Yamaguchi N, Kimura S, McBride OW, Hori H, Yamada Y, Kanamori T, Yamakoshi H ... High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion. GRCh38: ...

https://en.wikipedia.org/wiki/Collagen,_type_XVI,_alpha_1

"Entrez Gene: COL4A4 collagen, type IV, alpha 4". Hinek A (1995). "Nature and the multiple functions of the 67-kD elastin-/ ... 2003). "Type-IV collagen related diseases". J. Nephrol. 16 (2): 314-6. PMID 12768082. Torra R, Tazón-Vega B, Ars E, Ballarín J ... Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another ... Murata K, Motayama T, Kotake C (1986). "Collagen types in various layers of the human aorta and their changes with the ...

https://en.wikipedia.org/wiki/Collagen,_type_IV,_alpha_4

Type XXVII collagen is related to the "fibrillar" class of collagens and may play a role in development of the skeleton. ... COL27A1 is a type XXVII collagen. It was discovered by James Pace. This gene appears to be turned on in cartilage, the eye, and ... Fibrillar collagens, such as COL27A1, compose one of the most ancient families of extracellular matrix molecules. They form ... Collagen alpha-1 (XXVII) chain (COL27A1) is a protein that in humans is encoded by the COL27A1 gene. ...

https://en.wikipedia.org/wiki/Collagen,_type_XXVII,_alpha_1

... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... "Entrez Gene: COL5A2 collagen, type V, alpha 2". Mann K (1992). "Isolation of the alpha 3-chain of human type V collagen and ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ...

https://en.wikipedia.org/wiki/Collagen,_type_V,_alpha_2

This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha ... Epidermolysis bullosa acquisita involves an autoimmune reaction to this form of collagen. Collagen, type VII, alpha 1 forms a ... of type VII collagen is amino-terminal and chimeric. Homology to cartilage matrix protein, the type III domains of fibronectin ... including laminin-5 and collagen IV, contribute greatly to the overall stability of the basement membrane. Type VII collagen is ...

https://en.wikipedia.org/wiki/Collagen,_type_VII,_alpha_1

... type III collagen is also an important regulator of the diameter of type I and II collagen fibrils. Type III collagen is also ... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... Type III collagen could also be important in several other human diseases. Increased amounts of type III collagen are found in ... Type III collagen is one of the fibrillar collagens whose proteins have a long, inflexible, triple-helical domain. Type III ...

https://en.wikipedia.org/wiki/Collagen,_type_III,_alpha_1

... of type IV collagen in synovial capillaries by immunohistochemistry using a monoclonal antibody against human type IV collagen ... Collagen Type-IV collagen Alport syndrome GRCh38: Ensembl release 89: ENSG00000188153 - Ensembl, May 2017 GRCm38: Ensembl ... "Entrez Gene: COL4A5 collagen, type IV, alpha 5 (Alport syndrome)". Lemmink HH, Schröder CH, Monnens LA, Smeets HJ (1997). "The ... Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another ...

https://en.wikipedia.org/wiki/Collagen,_type_IV,_alpha_5

"Entrez Gene: COL14A1 collagen, type XIV, alpha 1 (undulin)". "COL14A1 - Collagen alpha-1(XIV) chain precursor - Homo sapiens ( ... 2005). "Collagen types XII and XIV are present in basement membrane zones during human embryonic development". J. Mol. Histol. ... Tono-Oka S, Tanase S, Miike T, Tanaka H (1996). "Transient expression of collagen type XIV during muscle development and its ... Collagen alpha-1(XIV) chain is a protein that in humans is encoded by the COL14A1 gene. It likely plays a role in collagen ...

https://en.wikipedia.org/wiki/Collagen,_type_XIV,_alpha_1

It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of the type IV collagen and plays a role in ... collagen". FEBS Letters. 225 (1-2): 188-94. doi:10.1016/0014-5793(87)81155-9. PMID 3691802. "Entrez Gene: COL4A1 collagen, type ... Type IV collagen is the major structural component of basement membranes, which contains two or three COL4A1 proteins. Thus, ... COL4A1 belongs to the type IV collagen family and contains three domains: a short N-terminal domain, a long triple-helical 7S ...

https://en.wikipedia.org/wiki/Collagen,_type_IV,_alpha_1

Fibril Associated Collagens with Interrupted Triple Helices) (Type IX, XII, XIV, XIX, XXI) Short chain (Type VIII, X) Basement ... of the collagen in the human body is type I collagen. However, as of 2011, 28 types of human collagen have been identified, ... Type XIII, XVII) Microfibril forming (Type VI) Anchoring fibrils (Type VII) The five most common types are: Type I: skin, ... With type I collagen and possibly all fibrillar collagens, if not all collagens, each triple-helix associates into a right- ...

https://en.wikipedia.org/wiki/Collagen

... collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to ... This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted ... collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". Genomics ... "Entrez Gene: COL12A1 collagen, type XII, alpha 1". Oh SP, Taylor RW, Gerecke DR, et al. (1992). "The mouse alpha 1(XII) and ...

https://en.wikipedia.org/wiki/Collagen,_type_XII,_alpha_1

Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. ... "Entrez Gene: COL9A2 collagen, type IX, alpha 2". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...

https://en.wikipedia.org/wiki/Collagen,_type_IX,_alpha_2

Several types of catenins work with N-cadherins to play an important role in learning and memory. Cell-cell adhesion complexes ... Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR (October 2011). "A role for collagen XXIII in cancer cell ... For instance, higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened ... levels of collagen helped facilitate adhesions and anchorage-independent cell growth and provided evidence of collagen XXIII's ...

https://en.wikipedia.org/wiki/Catenin

Due to its many twists and turns, it is a common place for a type of horse colic called an impaction. The small colon is 3.0 to ... Once a tendon is damaged the tendon will always be weaker, because the collagen fibres tend to line up in random arrangements ... As tendons develop they lay down collagen, which is the main structural protein of connective tissue. As tendons pass near bony ... The mare has two ovaries, usually 7 to 8 cm (2.8 to 3.1 in) in length and 3 to 4 cm (1.2 to 1.6 in) thick, that generally tend ...

https://en.wikipedia.org/wiki/Equine_anatomy

Children under the age of eight are susceptible to dental fluorosis. Overdose of fluoride can potentially cause neurotoxicity ... Fluoride-containing toothpaste can be classified into two types, namely low-fluoride and high-fluoride toothpaste. Low-fluoride ... SDF, in addition to performing the functions of conventional topical fluorides, is suggested to have collagen-conserving ... 149 (8): 671-679.e1. doi:10.1016/j.adaj.2018.03.028. PMC 6064675. PMID 29805039. Qiao, Lichun; Liu, Xuan; He, Yujie; Zhang, ...

https://en.wikipedia.org/wiki/Topical_fluoride

... such as expression of several types of collagens and protein vimentin, a part of cytoskeletal filaments. Unlike fibroblasts, ... Fibroblast-like synoviocytes (FLS) represent a specialised cell type located inside joints in the synovium. These cells play a ... 2010). "Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production". Science. 327 (5965): 580- ... The inner layer is mainly composed of two cell types, specialized macrophages (macrophage-like synovial cells) and fibroblast- ...

https://en.wikipedia.org/wiki/Fibroblast-like_synoviocyte

"Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl ... is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous ... 8 (7): 783-95. doi:10.1101/gad.8.7.783. PMID 7926767. Heaney C, Kolibaba K, Bhat A, Oda T, Ohno S, Fanning S, Druker BJ ( ... 93 (8): 2707-20. doi:10.1182/blood.V93.8.2707. PMID 10194451. Wang B, Golemis EA, Kruh GD (July 1997). "ArgBP2, a multiple Src ...

https://en.wikipedia.org/wiki/ABL_(gene)

While there may be some validity to the idea that for various types of specific damage detailed below that are by-products of ... Chemical damage to structural proteins can lead to loss of function; for example, damage to collagen of blood vessel walls can ... With respect to specific types of chemical damage caused by metabolism, it is suggested that damage to long-lived biopolymers, ... Horvath S (2013). "DNA methylation age of human tissues and cell types". Genome Biology. 14 (10): R115. doi:10.1186/gb-2013-14- ...

https://en.wikipedia.org/wiki/Senescence

Excessive pronation of the foot (over 5 degrees) in the subtalar joint is a type of mechanical mechanism that can lead to ... This lack of blood supply can lead to the degradation of collagen fibers and inflammation. Tightness in the calf muscles has ... It is also a known side effect of fluoroquinolone antibiotics such as ciprofloxacin, as are other types of tendinitis. Swelling ... Increased water content and disorganized collagen matrix in tendon lesions may be detected by ultrasonography or magnetic ...

https://en.wikipedia.org/wiki/Achilles_tendinitis

It is also unlikely that Paleolithic hunter-gatherers were affected by modern diseases of affluence such as type 2 diabetes, ... 19 February 2019). "Exceptionally high δ15N values in collagen single amino acids confirm Neandertals as high-trophic level ... For instance, archaeological evidence from art and bear remains reveals that the bear cult apparently involved a type of ... collagen samples shed new light on their debated diet". Science Daily. Retrieved 21 February 2019. Wilford, John Noble (18 ...

https://en.wikipedia.org/wiki/Paleolithic

CDG syndrome type 1A CDG syndrome type 1B CDG syndrome type 1C CDG syndrome type 2 CDG syndrome type 3 CDG syndrome type 4 CDK4 ... hemolytic anemia Cold contact urticaria Cold urticaria Cole carpenter syndrome Coleman-Randall syndrome Colitis Collagen ... Tooth disease type 1C Charcot-Marie-Tooth disease type 2A Charcot-Marie-Tooth disease type 2B1 Charcot-Marie-Tooth disease type ... disease type 2C Charcot-Marie-Tooth disease type 2D Charcot-Marie-Tooth disease type 4A Charcot-Marie-Tooth disease type 4B ...

https://en.wikipedia.org/wiki/List_of_diseases_(C)

Tuberous sclerosis is also associated with a second type of angiofibroma, adenoma sebaceum, also termed facial angiofibroma, in ... spindle-shaped or star-shaped fibroblasts and ectatic blood vessels in a dense collagen fiber connective tissue background. In ... 32 (6): 413-8. doi:10.1111/j.0303-6987.2005.00358.x. PMID 15953374. S2CID 12366680. Zheng LQ, Huang Y, Han XC (May 2013). " ... 2 (3): 196-8. doi:10.1016/j.jdcr.2016.03.014. PMC 4885148. PMID 27274535. Liebman JJ, Nigro LC, Matthews MS (December 2014). " ...

https://en.wikipedia.org/wiki/Koenen's_tumor

Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ... integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. 276 (31): 29368-74. doi:10.1074/jbc. ... They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. ... Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells. The DX5 monoclonal ...

https://en.wikipedia.org/wiki/Integrin_alpha_2

The ISneck domain is a type of neck domain. There are two types of ISneck domain. This first is an ISneck which is interrupted ... The YadA head domain has eight repeat motifs, each fourteen residues in length. The Trp ring is the second-most-common TAA head ... Nummelin H, Merckel MC, Leo JC, Lankinen H, Skurnik M, Goldman A (2004). "The Yersinia adhesin YadA collagen-binding domain ... There are several types of head domain. Each domain helps the head to bind to a different component of the extracellular matrix ...

https://en.wikipedia.org/wiki/Trimeric_autotransporter_adhesin

Protein sequencing of the material showed it to be collagen. In November 2010, hunter David Bradt stumbled on an elasmosaur ... There are four major types of habitat within the refuge: river bottom, riparian zones and wetlands, shoreline, and upland ( ... On May 8, the Corps passed the Milk River, named for the amount of sediment contained in the river during the spring run-off. ... On the evening of May 8, the expedition camped a mile or two above Fort Peck Dam. On May 9, the Corps of Discovery entered what ...

https://en.wikipedia.org/wiki/Charles_M._Russell_National_Wildlife_Refuge

... mice made deficient in LECT2 using a gene knockout method developed more severe osteoarthritis induced by anti-type II collagen ... and other types of inflammation-related disorders; the metabolic syndrome and diabetes; and various types of liver disease. The ... Mice made deficient in the Lect2 gene were compared to wild-type mice in a model of high fatty acid diet-induced obesity and ... Several cell types or tissues, e.g. osteoblasts, chondrocytes, cardiac tissue, gastrointestinal smooth muscle cells, and ...

https://en.wikipedia.org/wiki/LECT2

At high temperatures, the rate of collagen loss will be accelerated and extreme pH can cause collagen swelling and accelerated ... The study of diagenesis in rocks is used to understand the geologic history they have undergone and the nature and type of ... During this phase, most bone collagen is lost and porosity is increased. The dissolution of the mineral phase caused by low pH ... Due to the increase in porosity of bones through collagen loss, the bone becomes susceptible to hydrolytic infiltration where ...

https://en.wikipedia.org/wiki/Diagenesis

This enzyme catalyses the following chemical reaction Hydrolysis of proteins including elastin, collagen types III and IV, ... 255 (8): 3482-6. PMID 6767718. Dreyfus LA, Iglewski BH (March 1986). "Purification and characterization of an extracellular ...

https://en.wikipedia.org/wiki/Pseudolysin

Collagen fibers have about a 4% elastic zone where fibers stretch out with increased load on the joint. However, exceeding this ... type of cold compress that is activated similarly to a blood pressure cuff) have been effective in reducing swelling and ... Ligaments are tough, inelastic fibers made of collagen that connect two or more bones to form a joint and are important for ... Chronic sprains are caused by repetitive movements leading to overuse.[citation needed] Ligaments are collagen fibers that ...

https://en.wikipedia.org/wiki/Sprain

The most widely used substance, gluteraldehyde crosslinked collagen (GAX collagen) proved to be of value in many patients. The ... This type of intervention can take a person months to learn and would not be a therapy option for people who are not physically ... There is no evidence that one type of incontinence pad is superior with regard to skin health. A pessary is a medical device ... Rortveit, G.; Hannestad, Y. S.; Daltveit, A. K.; Hunskaar, S. (December 2001). "Age- and type-dependent effects of parity on ...

https://en.wikipedia.org/wiki/Stress_incontinence

There are numerous types of liposuction. Some can be described as techniques or modalities. Often surgeons will use two or more ... Referred to as Smart Lipo, this technique uses laser technology to coagulate and tighten the skin and boost collagen ... Referred to as "a vibrating cannula" in research studies, PAL uses a specific type of wand that creates an up and down, ... Liposuction, or simply lipo, is a type of fat-removal procedure used in plastic surgery. Evidence does not support an effect on ...

https://en.wikipedia.org/wiki/Liposuction

... is a type of receptor which binds one or more signaling peptides or signaling proteins. An example ... Asprosin Bombesin Calcitonin Carnosine CART CLIP DSIP Enteroglucagon Formyl peptide GALP GIP GRP Integrin ligands collagens ... 8-37) MK-3207 Olcegepant Rimegepant SB-268262 Telcagepant Ubrogepant Antibodies Eptinezumab Erenumab Fremanezumab Galcanezumab ...

https://en.wikipedia.org/wiki/Signaling_peptide_receptor

Eye surgery List of surgeries by type Cillino, S; Pace F Di; Cillino G; Casuccio A (Sep 2011). "Biodegradable collagen matrix ... Bleb leak - may cause flat bleb; leaking blebs can be revised with the use of ologen collagen matrix or bandage contact lens ... Dietlein TS, Rosentreter A. "Secondary subconjunctival implantation of biodegradable porous collagen matrix for treating ocular ... the use of biodegradable spacer or ologen collagen matrix implant may be implemented. Trabeculectomy is the most common ...

https://en.wikipedia.org/wiki/Trabeculectomy

"Glycated albumin stimulation of PKC-beta activity is linked to increased collagen IV in mesangial cells". The American Journal ... and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gene expression in cultured human vascular smooth ... 12 (8): 2352-63. doi:10.1091/mbc.12.8.2352. PMC 58599. PMID 11514621. Knöchel S, Schuler-Metz A, Knöchel W (November 2000). "c- ... 85 (8): 747-52. doi:10.1016/j.biochi.2003.09.006. PMID 14585541. Lee W, Haslinger A, Karin M, Tjian R (January 1987). " ...

https://en.wikipedia.org/wiki/AP-1_transcription_factor

3 to 5 eight-hour treatment sessions in consecutives days Hypoxic hepatitis. 3 eight-hour treatment sessions in consecutives ... There are various types of hepatocytes that are used in these devices. Porcine hepatocytes are often used due to ease of ... Hepatocytes are suspended in a gel solution such as collagen, which is injected into a series of hollow fibers. In the case of ... A liver support system or diachysis is a type of therapeutic device to assist in performing the functions of the liver. Such ...

https://en.wikipedia.org/wiki/Liver_support_system

IGF type 1 receptor - IGF type 2 receptor - IgG - IgM - immediate-early protein - immune cell - immune system - immunoglobulin ... factor VIII - FADH - FADH2 - Fat - Fatty acid - fc immunoglobulin - fc receptor - feedback inhibition - fermentation - fetal ... collagen - colloid - colony-stimulating factor - colony stimulating factor 1 receptor - colorimeter - comparative biochemistry ... interferon type I - interferon type II - interferon-alpha - interferon-beta - interleukin receptor - interleukin-1 receptor - ...

https://en.wikipedia.org/wiki/Index_of_biochemistry_articles

... such as the Aquaflow collagen wick, ologen Collagen Matrix, or Xenoplast glaucoma implant. Laser-assisted NPDS is performed ... The most common type is open-angle (wide angle, chronic simple) glaucoma, in which the drainage angle for fluid within the eye ... A number of types of glaucoma surgeries may be used in people who do not respond sufficiently to other measures. Treatment of ... Since then, several types of implants have followed on from the original: the Baerveldt tube shunt, or the valved implants, ...

https://en.wikipedia.org/wiki/Glaucoma

Chernousov MA, Stahl RC, Carey DJ (1996). "Schwann cells secrete a novel collagen-like adhesive protein that binds N-syndecan ... this deactivated gene is found across many cancer types in this study to be the underlying cause of the disease. Tne CUX1 gene ... 46 (1): 33-8. doi:10.1038/ng.2846. PMC 3874239. PMID 24316979. Sohda M, Misumi Y, Yamamoto A, Nakamura N, Ogata S, Sakisaka S, ... 8 (10): 1060-73. doi:10.1101/gr.8.10.1060. PMC 310788. PMID 9799793. Oka T, Ungar D, Hughson FM, Krieger M (April 2004). "The ...

https://en.wikipedia.org/wiki/CUTL1

Compared to Type I PEL, Type II PEL occurs more often in older individuals, is less often associated with EBV, and more often ... tightly woven collagen fibers) which forms around breast implants. Less frequently, individuals present with extracavitary ... than the malignant cells in Type I PEL. The response to treatment and prognosis of Type II PEL is poor but may be somewhat ... Type II PEL may be a less severe disease than Type I PEL, at lease in certain cases. PEL is generally resistant to cancer ...

https://en.wikipedia.org/wiki/Primary_effusion_lymphoma

"Establishing collagen quality criteria for sulphur isotope analysis of archaeological bone collagen". Archaeological and ... Many methods tracking these types of changes have been developed using a variety of skeletal series. For instance, in children ... Based on stable isotope levels, eight Cobern Street Burial Ground individuals consumed a diet based on C4 (tropical) plants in ... Though bone collagen is abundant in skeletal remains, less than 1% of the tissue is made of sulfur, making it imperative that ...

https://en.wikipedia.org/wiki/Bioarchaeology

... is also an inhibitor of collagen type I gene expression and as a consequence it may inhibit tumor cell growth. ... 8 (3): 311-7. doi:10.1038/nchembio.790. PMC 3281520. PMID 22327401. (Drugs with non-standard legal status, Articles with ... 324 (5932): 1334-8. Bibcode:2009Sci...324.1334S. doi:10.1126/science.1172638. PMC 2803727. PMID 19498172. "A new lead for ... 324 (5932): 1334-8. Bibcode:2009Sci...324.1334S. doi:10.1126/science.1172638. PMC 2803727. PMID 19498172. Sundrud MS, Koralov ...

https://en.wikipedia.org/wiki/Halofuginone

VIII) collagen. Learn about this gene and related health conditions. ... The COL8A2 gene provides instructions for making a component of type VIII collagen called alpha 2( ... VIII) collagen. Type VIII collagen is largely found within the front surface of the eye, called the cornea. Type VIII collagen ... To construct type VIII collagen, one subunit of the alpha 2(VIII) collagen protein interacts with two subunits of another ...

https://medlineplus.gov/genetics/gene/col8a2/

... placebo-controlled trial of oral type I collagen treatment in patients with diffuse cutaneous systemic sclerosis: I. oral type ... Advances in tissue engineering and use of type 1 bovine collagen particles in wound bed preparation. Rudnick A. Rudnick A. J ... Augmentation of a rotator cuff suture repair using rhPDGF-BB and a type I bovine collagen matrix in an ovine model. Hee CK, ... The use of a Type-I lyophilisate collagen as an osteoinductive factor in pseudarthroses of the forearm. Strassmair M, Mont MA, ...

http://www.ncbi.nlm.nih.gov/sites/entrez?DB=pubmed&term=BOVINE+TYPE+I+COLLAGEN/TU

Changes in the process of forming collagen.. Type VIII *Resembles Type II and Type III OI in appearance and symptoms. ... Type II is the most severe form of OI. Other types of OI have symptoms that fall between Type I and Type II. Following is an ... a change or defect in the genes that carry the instructions for making type I collagen causes OI. Type I collagen is a material ... Improperly formed collagen.. Type III *Most severe type among those who survive the neonatal period and usually results in the ...

http://www.niams.nih.gov/health_info/bone/osteogenesis_imperfecta/

Vitamin A-containing lipocytes and formation of type III collagen in liver injury G Kent, S Gay, T Inouye, R Bahu, O T Minick, ... Vitamin A-containing lipocytes and formation of type III collagen in liver injury G Kent et al. Proc Natl Acad Sci U S A. 1976 ... Publication types *. Research Support, U.S. Govt, Non-P.H.S. Actions ... the precursor of the fibroblasts responsible for parenchymal fibrillogenesis and under these conditions forms type III collagen ...

https://pubmed.ncbi.nlm.nih.gov/1068482

Immunohistochemical distribution of type IV collagen and laminin.. Kuwashima Y; Uehara T; Kurosumi M; Kishi K; Shiromizu K; ... Acta Cytol; 2000; 44(3):485-8. PubMed ID: 10834020. [No Abstract] [Full Text] [Related] ... 8. Basement membrane status in undifferentiated carcinomas of the ovary. ...

https://pubmedhh.nlm.nih.gov/biomarkers/search.php?id=8669877&mod=related&page=1&outid=&proj=

Alterations in type IV collagen often result in abnormal inner ear function, which can lead to hearing loss. In the eye. , this ... Type IV collagen is also an important component of inner ear structures. , particularly the organ of Corti, that transform ... Pescucci C, Longo I, Bruttini M, Mari F, Renieri A. Type-IV collagen related diseases. J Nephrol. 2003 Mar-Apr;16(2):314-6. ... Mutations that disrupt type IV collagen can result in misshapen lenses and an abnormally colored retina. ...

https://ghr.nlm.nih.gov/condition/alport-syndrome

productA high-quality collagen solution providing in vivo-like ECM structures for 3D cell culture and coatings , High ... Collagen Type I. A high-quality collagen type I (bovine or rat tail origin) for cell culture applications (e.g., 3D gels, ... cell-culture-microscopy/107-collagen-type-i-rat-tail.html Cart 0 There are no more items in your cart ... A high-quality collagen type I (bovine or rat tail origin) for cell culture applications (e.g., 3D gels, scaffolds, and coating ...

https://ibidi.com/cell-culture-microscopy/107-collagen-type-i-rat-tail.html

She studies the effect of a matrix protein called type VIII collagen on vessel stiffening. ...

https://www.marsdd.com/media-centre/u-of-t-expands-research-facilities-in-new-partnership-with-mars/

The vitreous gel has an outer cortex consisting primarily of type II collagen that is attached to the internal limiting ... it has the advantage that it does not degrade collagen type IV, a major component of the ILM.[8] ... consisting primarily of type IV collagen. The vitreous plays a central role in many common and potentially blinding diseases ... Types of Hair Loss and Treatment Options, Including the Novel Low-level Light Therapy and its Proposed Mechanism ...

https://www.medscape.com/viewarticle/823054

The proteins are named RspA and RspB and serve in helping the microorganism bind to biotic (collagen types I and IV) and ... Adhesive surface proteins of Erysipelothrix rhusiopathiae bind to polystyrene, fibronectin, and type I and IV collagens. J ... RspA is the type that is by far most prevalent in animals with erysipelas. However, a single study isolated a E. rhusiopathiae ...

http://emedicine.medscape.com/article/1054170-overview

... revealed a loss of cellular protection by luteolin and a decrease in collagen, suggesting that luteolin acts by targeting and ... revealed a loss of cellular protection by Luteolin and a decrease in collagen, suggesting that Luteolin acts by targeting and ... and increased collagen expression. Continued cellular experiments using 3-TYP, an inhibitor of Sirtuin 3 (SIRT3), ... and increased collagen expression. Continued cellular experiments using 3-TYP, an inhibitor of Sirtuin 3 (SIRT3), ...

https://www.frontiersin.org/articles/10.3389/fphar.2021.728261/full

Retinoids stimulate collagen production, lighten brown spots, and increase cell turnover. Using a small amount of a topical ... This is a BASIC skincare routine suitable for all skin types.". 8 ...

https://www.eatthis.com/news-habits-you-should-be-doing-daily/

9:00 am: Hai Pham, "Collagen Type VI Alpha 2 Deficiency Leads to Dento-alveolar Defects" ... 8:00 am - 9:30 am. SYMPOSIUM. Towards NIDCR 2030: From Development to Disease in Salivary Research at the NIH. NIDCR Scientific ... 8:50 am: Indu Ambudkar, "Ca2+ Signaling and Mitochondrial Defects in Radiation Induced Dry Mouth". 9:10 am: John Chiorini, " ... 8:10 am: Kenneth Yamada, "Cell Migration and Tissue Remodeling in Morphogenesis". 8:30 am: Jacqueline Mays, "From Infiltration ...

https://www.nidcr.nih.gov/news-events/nidcr-news/2019/nidcrsponsored-events-2019-iadr-general-session

Collagen Type-VIII, alpha1 Subunit Collagen alpha1(VIII) Procollagen Type VIII Type VIII Collagen Type VIII Procollagen ... Collagen Type-VIII, alpha1 Subunit Narrower Concept UI. M0369413. Registry Number. 0. Terms. Collagen Type-VIII, alpha1 Subunit ... It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains.. Terms. Collagen Type VIII Preferred Term Term UI T009010 ... It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains.. Entry Term(s). Collagen Type-VIII, alpha1 Chain ...

https://meshb.nlm.nih.gov/record/ui?ui=D024102

Fillers A substance such as collagen, hyaluronic acid, or fat can be used to "fill out" certain types of acne scars. Since ... Because collagen plays a role in the healing process, your skin produces new collagen as it repairs itself after a breakout. ... Some types of acne leave scars that appear as enlarged, raised growths of tissue. These acne scars are caused by too much scar ... Types of RashesMenopause BellyBaking Soda UsesMediterranean Diet Meal PlanHow to OrgasmApple Cider Vinegar BenefitsGallbladder ...

https://www.everydayhealth.com/acne/remove-acne-scars.aspx

Breakthrough in Arthritis & Joint Pain Treatment with Collagen Type 2 Protein. Detox Drinks. ... Type 1 Diabetes*Type 2 Diabetes*Cancer*Heart Attack*Pneumonia*Diseases A-Z ... Type 1 Diabetes*Type 2 Diabetes*Cancer*Heart Attack*Pneumonia*Diseases A-Z ... पीरियड्स से जुड़ी ये 8 बातें हैं असल जिंदगी में हैं झूठ, जानें कौन सी बातों पर कभी न करें विश्वास. ...

https://www.thehealthsite.com/baby-names/meaning-of-nikky-10835/

... lipped mussel extract and undenatured type II collagen demonstrated clinically important effects for pain reduction among eight ... Only green-lipped mussel extract and undenatured type II collagen had clinically important effects on pain at medium term. No ... Five supplements (undenatured type II collagen, avocado/soybean unsaponifiables (ASU), glucosamine, chondroitin and diacerein) ... Another six (undenatured type II collagen, avocado soybean unsaponifiables, methylsulfonylmethane, diacerein, glucosamine and ...

https://bjsm.bmj.com/content/52/3/167.long?fbclid=IwAR3UxYwkc6msS1w17c_52MnW89CsO9R_GaiXvIL2b00RD6lvTJ7Rdc1lNQA

Structure and multiple conformations of the Kunitz-type domain from human type VI collagen alpha 3(VI) chain in solution. ... Conversion of the Kunitz-type module of collagen VI into a highly active trypsin inhibitor by site-directed mutagenesis. Eur. J ... 8, 682-686. Kohfeldt, E., Göhring, W., Mayer, U., Zweckstetter, M., Mayer, U., Holak, T. A., Chu, M.-L. & Timpl, R. (1996). ...

https://spin.niddk.nih.gov/bax/people/zweckstetter.html

Fibrosis, characterized by increased immunoexpression of collagen type I by 8 weeks and connective tissue growth factor by 12 ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=%27ergonom%2A%27+or+musculoskeletal+or+repetitive+or+carpal&f1=TI&Startyear=&t1=1&s2=%27ergonom%2A%27+or+musculoskeletal+or+repetitive+or+carpal&terms=3&Adv=1&ct=&B1=Search&f2=KW&Limit=500&Sort=DP+DESC&D1=10&EndYear=&PageNo=303&RecNo=3025&View=f&

The volume of collagen fibrils in septal walls increased and was linked with an increase in blood-gas barrier thickness. A high ... Two, eight and twelve weeks after induction of Nedd4-2 knockout, lungs were fixed and subjected to design-based stereological ... Volume and surface area of alveolar epithelial type I cells were reduced, which could not be compensated by a corresponding ... Abstract: Our previous study showed that in adult mice, conditional Nedd4-2-deficiency in club and alveolar epithelial type II ...

https://tools.niehs.nih.gov/portfolio/index.cfm?do=portfolio.publicationDetail&id=4334181

... eight genes related to neuronal development have been associated with different CCDD phenotypes. By using linkage analysis, ... By using linkage analysis, candidate gene screening, and exome sequencing, we identified three mutations in collagen, type XXV ... Abnormal ocular motility is a common clinical feature in congenital cranial dysinnervation disorder (CCDD). To date, eight ... 2015 Jan 8;96(1):147-52. doi: 10.1016/j.ajhg.2014.11.006. Epub 2014 Dec 11. ...

https://pubmed.ncbi.nlm.nih.gov/25500261/?dopt=Abstract

... a bioinspired in situ gelling hydrogel system composed of naturally occurring biopolymers collagen and hyaluronic acid was ... The vitreous body is mainly composed of hyaluronic acid and different types of collagens, primarily type II collagen [31,32]. ... Eight-arm polyethylene glycol (PEG) succinimidyl glutarate (tripentaerythritol) (8-arm PEG, MW: 20 kDa and 40 kDa) were ... Collagen (type II) from calf articular joints was purchased from Elastic Products Company, Inc (Owensville, MO). Sodium ...

https://www.mdpi.com/1999-4923/13/9/1335

... alendronate 5 and 10 mg/day reduced cross-linked N-telopeptides of type I collagen (a marker of bone resorption) by ... such as deoxypyridinoline and cross-linked N-telopeptides of type I collagen). These biochemical changes tended to return ... deoxypyridinoline and cross-linked N-telopeptides of type l collagen, by approximately 50% and 70%, respectively, to reach ... with alendronate 10 mg/day for two years reduced urinary excretion of cross-linked N-telopeptides of type I collagen by ...

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5c49d7fc-c76a-40c9-8c43-68b731230f0e

Collagen Type I Alpha 2 Chain (COL1A2), Galectin 4 (LGALS4) and Tetraspanin 8 (TSPAN8) mRNAs as blood biomarkers for colorectal ...

https://www.unibo.it/sitoweb/enea.ferlizza2/publications

2 Tablespoons integral collagen (paleo friendly dairy/soy-free protein). *half of a banana (sliced and frozen is nice) ... August 8, 2021. by Tasha Hackett 1 Comment This post may contain affiliate links which wont change your price but will share ... Recipe type: snack. Ingredients. *8 oz. coconut milk. *2 Tablespoons cacao or cocoa powder ... Cook on low for 6-8 hours or until pork is tender and falling apart. ...

https://www.heavenlyhomemakers.com/category/gluten-free

... heterogeneous marking of type II collagen and prevalence of this type of fiber in the three zones of cartilage. Thus, we ... increased collagen density, less heterogeneous marking of type II collagen in the lateral condyle, the predominance of this ... collagen morphometry, the identification of the types of collagen and immunohistochemical analysis. The results show that the ... decreased volumetric proportion of collagen bicondylar, marking heterogeneous collagen type II predominance of such fibers in ...

https://www.teses.usp.br/teses/disponiveis/10/10132/tde-01112013-115832/pt-br.php

... loss of type IV collagen, type VII collagen and laminin immunostaining. Equine Vet J Suppl 1998:139-144. ... On the dermal side of the basement membrane, bundles of collagen I connect to the basement membrane via hook-like anchoring ... collagen IV, begins to disappear.2 Previously, damage to the lamellar basement membrane was attributed to MMP release and ... fibrils (collagen VII). With the aberrant cell signalling of laminitis, hemidesmosomes no longer attach LEBCs to the basement ...

https://www.equipodiatry.com/news/articles/-thirty-years-of-laminitis-research---what-have-i-learned-

The major focus was to highlight the extraordinary role and importance of the short chain network forming type VIII collagen in the extracellular matrix of undiseased arteries and of atherosclerotic plaques. (nih.gov)
2 Schuppan D, Gressner A M. Function and metabolism of collagens and other extracellular matrix proteins. (thieme-connect.com)

These mutations impair the structure of alpha 2(VIII) collagen, probably preventing the abnormal protein from being incorporated into type VIII collagen fibers. (medlineplus.gov)
Dermal collagen fibers are disorderly arranged, with a whorled appearance. (medscape.com)
Electron microscopy reveals defects in the striations of the collagen fibers, with large or small fibrils. (medscape.com)

While Type II Collagen is less prevalent within our bodies, it still offers great benefit to the aging body by promoting joint and cartilage health! (familychristian.com)
Collagen Type II is the form of collagen that promotes joint and cartilage health. (familychristian.com)
Instead of forming collagen molecules, the abnormal COL2A1 protein builds up in cartilage cells (chondrocytes). (medlineplus.gov)
Inflammation serves an important role in the progression of osteoarthritis (OA), and IL‑1β may act as a catabolic factor on cartilage, reducing the synthesis of primary cartilage components type II collagen and aggrecan. (spandidos-publications.com)
IL-1β is an important cytokine in OA progression by acting as a catabolic factor to reduce the synthesis of two primary cartilage components, the type II collagen (COL2A1) and aggrecan (ACAN) ( 6 ). (spandidos-publications.com)

The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. (nih.gov)
Production of MMP-9 allows T cells to pass through collagen IV-containing basement membrane. (medscape.com)
The molecular conformation of the lamellar basement membrane is altered 12 hours after dosing with oligofructose and a major constituent of the basement membrane, collagen IV, begins to disappear.2 Previously, damage to the lamellar basement membrane was attributed to MMP release and activation and I promoted this concept for many years. (equipodiatry.com)

An imbalanced metabolism may lead to uncontrolled collagen accumulation reducing vessel wall velocity, frequently resulting in arterial occlusion or thrombosis. (nih.gov)
ApoE (-/-)) resulted in development of plaques with thin fibrous caps because of decreased smooth muscle cell migration and proliferation and reduced accumulation of fibrillar type I collagen . (bvsalud.org)
4. Nakanishi Y, Nogawa H, Hashimoto Y, Kishi J, Hayakawa T. Accumulation of collagen III at the cleft points of developing mouse submandibular epithelium. (southernbiotech.com)
Our previous study showed that in adult mice, conditional Nedd4-2-deficiency in club and alveolar epithelial type II (AE2) cells results in impaired mucociliary clearance, accumulation of Muc5b and progressive, terminal pulmonary fibrosis within 16 weeks. (nih.gov)

Collagen synthesis in atherosclerosis: too much and not enough. (nih.gov)
19. Fibrosis in undifferentiated (anaplastic) thyroid carcinomas: evidence for a dual action of tumour cells in collagen type I synthesis. (nih.gov)
Ehlers-Danlos syndromes (EDS), the name given to a group of more than 10 different inherited, clinically and genetically heterogeneous group of connective-tissue disorders, involves a genetic defect in collagen and connective-tissue synthesis and structure. (medscape.com)

1996 May 3;63(1):123-8. (medlineplus.gov)

Published online 2018 Mar 8. (nih.gov)

The COL8A2 gene mutations that cause the early-onset variant of Fuchs endothelial dystrophy replace single protein building blocks in alpha 2(VIII) collagen. (medlineplus.gov)
Mutations in these genes result in abnormalities of the type IV collagen in glomeruli, which prevents the kidneys from properly filtering the blood and allows blood and protein to pass into the urine. (nih.gov)
Mutations that disrupt type IV collagen can result in misshapen lenses and an abnormally colored retina. (nih.gov)
By using linkage analysis, candidate gene screening, and exome sequencing, we identified three mutations in collagen, type XXV, alpha 1 (COL25A1) in individuals with autosomal-recessive inheritance of CCDD ophthalmic phenotypes. (nih.gov)
Mutations in the COL2A1 gene interfere with the assembly of type II collagen molecules, reducing the amount of this type of collagen in the body. (medlineplus.gov)

To construct type VIII collagen, one subunit of the alpha 2(VIII) collagen protein interacts with two subunits of another protein called alpha 1(VIII) collagen. (medlineplus.gov)

Collagens play a central role in maintaining the integrity and stability of the undiseased as well as of the atherosclerotic vessel wall. (nih.gov)
A reduced production of collagen and its uncontrolled degradation may affect the stability of the vessel wall and especially of the atherosclerotic plaques by making them prone to rupture and aneurysm. (nih.gov)
Type VIII collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis. (bvsalud.org)

Type I collagen is also in other connective tissues such as tendon, ligament, lung, and skin, and these tissues can sometimes be affected. (nih.gov)
Fibrosis, characterized by increased immunoexpression of collagen type I by 8 weeks and connective tissue growth factor by 12 weeks, was evident. (cdc.gov)

Crosslinked porous type I collagen scaffolds (O ~ 14 mm) were sutured into the lesion. (ru.nl)

For most people, a change or defect in the genes that carry the instructions for making type I collagen causes OI. (nih.gov)
The defect in the genes causes the body to make collagen incorrectly or not make enough, leading to weak bones that break more easily. (nih.gov)
These genes each provide instructions for making one component of a protein called type IV collagen. (nih.gov)
To date, eight genes related to neuronal development have been associated with different CCDD phenotypes. (nih.gov)

Collagens in the atherosclerotic plaque signal regulation of cell behavior and provide tensile strength to the fibrous cap. (bvsalud.org)

Consistent with this notion, macrophages can undergo two types of activation, characterized by differential gene expression programs depending of the triggering stimulus [ 27 ]. (hindawi.com)
The first type of activation is known as classical and leads to inflammatory or M1 activated macrophages. (hindawi.com)

Am J Med Genet A. 2004 Aug 30;129A(2):144-8. (medlineplus.gov)

20. Tubular atrophy, interstitial fibrosis, and inflammation in type 2 diabetic db/db mice. (nih.gov)

It consists of collagens, glycoproteins, proteoglycans, glycosaminoglycans and molecules that are bound specifically by the ECM, such as certain growth factors/cytokines, matrix metalloproteinases (MMPs) and processing enzymes such as tissue transglutaminase and procollagen propeptidases. (thieme-connect.com)
In a study in Skin Pharmacology and Physiology, women who popped a 2,500-milligram Verisol collagen peptide supplement (you can buy them at health-food stores) daily for eight weeks had a 20 percent reduction in eye-wrinkle volume, a 65 percent increase of procollagen type I, and an 18 percent increase in elastin. (allure.com)

The volume of collagen fibrils in septal walls increased and was linked with an increase in blood-gas barrier thickness. (nih.gov)

Examples are peptides derived from collagens VI (stress activation) and XIV (stress relaxation), or collagenous consensus peptides that remove ECM-bound MMPs and growth factors. (thieme-connect.com)
Crash course in peptides: They're amino acid chains that build collagen in the skin. (allure.com)

Quantitative data did not show any abnormalities until 8 weeks compared to controls. (nih.gov)

Alterations in type IV collagen often result in abnormal inner ear function, which can lead to hearing loss. (nih.gov)

1. Collagen VIII influences epithelial phenotypic changes in experimental diabetic nephropathy. (nih.gov)
8. β-Casomorphin-7 attenuates the development of nephropathy in type I diabetes via inhibition of epithelial-mesenchymal transition of renal tubular epithelial cells. (nih.gov)
Volume and surface area of alveolar epithelial type I cells were reduced, which could not be compensated by a corresponding increase of AE2 cells. (nih.gov)

We conclude that in atherosclerosis , type VIII collagen is up-regulated in the absence of ApoE and functions to increase smooth muscle cell proliferation and migration. (bvsalud.org)
14. Type VIII collagen modulates TGF-β1-induced proliferation of mesangial cells. (nih.gov)
1. Rasmussen LM, Hansen PR, Ledet T. Homocysteine and the production of collagens, proliferation and apoptosis in human arterial smooth muscle cells. (southernbiotech.com)

Histological examination showed that the collagen scaffold degraded slowly and new collagen, elastin and mesothelium were deposited. (ru.nl)

This gene encodes one of the two alpha chains of type VIII collagen. (nih.gov)
It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains. (nih.gov)

Zabel B, Hilbert K, Stoss H, Superti-Furga A, Spranger J, Winterpacht A. A specific collagen type II gene (COL2A1) mutation presenting as spondyloperipheral dysplasia. (medlineplus.gov)
Previous reports demonstrated that treatment with IL-1β decreases COL2A1 expression ( 6 ) and increases MMP-13 expression ( 8 ). (spandidos-publications.com)

Once these molecules are processed, they arrange themselves into long, thin bundles of mature type VIII collagen. (medlineplus.gov)

Type II Collagen is comprised of: glucosamine, chondroitin and hyaluronic acid. (familychristian.com)
Another six (undenatured type II collagen, avocado soybean unsaponifiables, methylsulfonylmethane, diacerein, glucosamine and chondroitin) revealed statistically significant improvements on pain, but were of unclear clinical importance. (bmj.com)

Clinically similar to Type IV OI in appearance and symptoms. (nih.gov)
Only green-lipped mussel extract and undenatured type II collagen had clinically important effects on pain at medium term. (bmj.com)

This review presents an overview on the four groups of vascular collagens and on their role in atherogenesis. (nih.gov)
In 1 patient, the vascular type of Ehlers-Danlos syndrome (EDS) was associated with mild hemophilia A. (medscape.com)
The access of monocytes and T cells to the vascular wall is controlled by matrix metalloproteinase 9 (MMP-9), a type IV collagenase that is produced in the vasculitic lesions of giant cell arteritis. (medscape.com)

Type I collagen is a material in bones that helps make them strong. (nih.gov)
Collagen has many different types and each of those types offer benefits to our hair, skin, nails and bones! (familychristian.com)
Type I collagen is used for strong hair, skin, nails and bones. (familychristian.com)
These Collagen types also help strengthen bones and nails. (familychristian.com)

We studied the response to arterial injury and the development of atherosclerosis in type VIII collagen knockout mice (Col8(-/-) mice ). (bvsalud.org)
Two, eight and twelve weeks after induction of Nedd4-2 knockout, lungs were fixed and subjected to design-based stereological investigation at the light and electron microscopic level. (nih.gov)

The molecular structure of type VIII collagen, its cellular origin, its implication in atherogenesis, its temporal and spatial expression patterns in human and experimental models of atherogenesis, the factors modulating its expression, and--not at least--its potential function is discussed. (nih.gov)
8. Human thyroid tumor cell lines derived from different tumor types present a common dedifferentiated phenotype. (nih.gov)
15. Collagen type VIII expression in human diabetic nephropathy. (nih.gov)
Structure and multiple conformations of the Kunitz-type domain from human type VI collagen alpha 3(VI) chain in solution. (nih.gov)

unlike some other enzymes, it has the advantage that it does not degrade collagen type IV, a major component of the ILM. (medscape.com)
That can trigger rosacea or eczema flare-ups and boost enzymes that destroy collagen and cause wrinkles and sagging over time. (allure.com)

By offering support for joints, this type of collagen can reduce the progression of arthritis! (familychristian.com)

8. Blush J, Lei J, Ju W, Silbiger S, Pullman J, Neugarten J. Estradiol reverses renal injury in Alb/TGF-β1 transgenic mice. (southernbiotech.com)

Collagen supplement benefits have been evaluated through published medical studies. (familychristian.com)
I hope you learned what collagen is, the types of collagen there are, and collagen supplement benefits! (familychristian.com)

8 Winnemoller M, Schmidt G, Kresse H. Influence of decorin on fibroblast adhesion to fibronectin. (thieme-connect.com)

These two types of Collagen promote hair, skin, nail and bone health. (familychristian.com)

The type VIII collagen fibril can be either a homo- or a heterotrimer. (nih.gov)

Medical Language System® (UMLS®) (Lindberg et relations between biomedical entities named in al, 1993) to determine relations between entities questions and the potential answer types and then found in the text by MetaMap (Aronson, 2001). (nih.gov)

Collagen Types I and III also stimulates the production of amino acids, in particular Glycine. (familychristian.com)

However, the most commonly researched types of collagen include: Types I, II and III. (familychristian.com)
As described above, Collagen Type I and Type III are the most commonly occurring collagen types within our bodies. (familychristian.com)
They are commonly seen in patients with type I. (medscape.com)

Type VIII collagen is a major component of Descemet's membrane, which is a tissue at the back of the cornea. (medlineplus.gov)

The COL8A2 gene provides instructions for making a component of type VIII collagen called alpha 2(VIII) collagen. (medlineplus.gov)
This gene provides instructions for making a protein that forms type II collagen. (medlineplus.gov)

As we all age, this type of collagen diminishes significantly. (familychristian.com)

It's also recommended to take these products with citrus, orange juice or supplements which contain Vitamin C. Vitamin C actually works as a co-enzyme to allow for better absorption of the collagen, which provides added benefit and better absorption. (familychristian.com)
One isolated report showed that patients with type VI disease benefited from oral vitamin C at 4 g/d. (medscape.com)
Healthy & Skin Friendly : Contains vitamin E and collagen which keeps your tired skin lively and healthy. (pinterest.it)

Type VIII collagen is largely found within the front surface of the eye, called the cornea. (medlineplus.gov)
Disclaimer: I am not a medical professional, and this article is based off of research I found online, as well as my own personal use of collagen supplements. (familychristian.com)
A non-fibrillar collagen originally found in DESCEMET MEMBRANE . (nih.gov)

Because collagen plays a role in the healing process, your skin produces new collagen as it repairs itself after a breakout. (everydayhealth.com)

Normal collagen structure, but less than the normal amount is produced. (nih.gov)

We evaluated the feasibility of using an acellular biodegradable collagen bioscaffold for a regenerative medicine approach to close a surgically created diaphragmatic defect in a rat model. (ru.nl)
Use of a collagen scaffold to close a surgically created diaphragmatic defect is feasible, with evidence of new tissue formation. (ru.nl)

One patient with Ehlers-Danlos syndrome type IV has been diagnosed with gastric adenocarcinoma. (medscape.com)

As they say, collagen is the "fountain of YOUTH," sought after by many who wish to maintain that young, vibrant skin. (familychristian.com)
These medical studies have proven that adding oral collagen to your daily routine can increase the elasticity of our skin, along with other benefits. (familychristian.com)
Essence : Each type of Mask For Various Skin Benefiting Results Such As Moisturization, Skin Nutrition, Skin Calming, Skin Elasticiy and Tightening. (pinterest.it)
2 ) Also, scarring tends to happen more as the skin loses collagen with age. (everydayhealth.com)

The vitreous gel has an outer cortex consisting primarily of type II collagen that is attached to the internal limiting membrane (ILM) consisting primarily of type IV collagen. (medscape.com)

If you want to skip the supplements, then make sure to include foods that are naturally rich in collagen in your diet. (familychristian.com)

Anatomy1

Diseases1

Chemicals and Drugs7

Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy. (1/44)

Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis. (2/44)

Human corneal epithelial cell viability and morphology after dilute alcohol exposure. (3/44)

Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. (4/44)

Identification of genes induced in regenerating Xenopus tadpole tails by using the differential display method. (5/44)

Molecular targets for tumour progression in gastrointestinal stromal tumours. (6/44)

Expression and supramolecular assembly of recombinant alpha1(viii) and alpha2(viii) collagen homotrimers. (7/44)

Endostatin promotes the anabolic program of rabbit chondrocyte. (8/44)

Collagen Type VIII

Factor VIII

Collagen

Collagen Type I

Collagen Type III

Glycogen Storage Disease Type VIII

Collagen Type IV

Collagen Type II

Descemet Membrane

Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy. (1/44)

Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis. (2/44)

Human corneal epithelial cell viability and morphology after dilute alcohol exposure. (3/44)

Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. (4/44)

Identification of genes induced in regenerating Xenopus tadpole tails by using the differential display method. (5/44)

Molecular targets for tumour progression in gastrointestinal stromal tumours. (6/44)

Expression and supramolecular assembly of recombinant alpha1(viii) and alpha2(viii) collagen homotrimers. (7/44)

Endostatin promotes the anabolic program of rabbit chondrocyte. (8/44)

Collagen, type VIII, alpha 1

Collagen, type VIII, alpha 2

Collagen, type XI, alpha 1

Collagen, type IX, alpha 1

Collagen, type IV, alpha 2

Collagen, type I, alpha 2

Collagen, type XVII, alpha 1

Collagen, type IX, alpha 3

Collagen, type VI, alpha 1

Collagen, type XIII, alpha 1

Collagen, type XV, alpha 1

Collagen, type I, alpha 1

Collagen, type VI, alpha 3

Collagen, type II, alpha 1

Collagen, type VI, alpha 2

Collagen, type XI, alpha 2

Type V collagen

Collagen, type V, alpha 1

Collagen, type XVI, alpha 1

Collagen, type IV, alpha 4

Collagen, type XXVII, alpha 1

Collagen, type V, alpha 2

Collagen, type VII, alpha 1

Collagen, type III, alpha 1

Collagen, type IV, alpha 5

Collagen, type XIV, alpha 1

Collagen, type IV, alpha 1

Collagen

Collagen, type XII, alpha 1

Collagen, type IX, alpha 2

Catenin

Equine anatomy

Topical fluoride

Fibroblast-like synoviocyte

ABL (gene)

Senescence

Achilles tendinitis

Paleolithic

List of diseases (C)

Koenen's tumor

Integrin alpha 2

Trimeric autotransporter adhesin

Charles M. Russell National Wildlife Refuge

LECT2

Diagenesis

Pseudolysin

Sprain

Stress incontinence

Liposuction

Signaling peptide receptor

Trabeculectomy

AP-1 transcription factor

Liver support system

Index of biochemistry articles

Glaucoma

CUTL1

Primary effusion lymphoma

Bioarchaeology

Halofuginone

COL8A2 gene: MedlinePlus Genetics

BOVINE TYPE I COLLAGEN/TU - Search Results - PubMed

Osteogenesis Imperfecta (Brittle Bone Disease) Types | NIAMS

Vitamin A-containing lipocytes and formation of type III collagen in liver injury - PubMed