A non-fibrillar collagen originally found in DESCEMET MEMBRANE. It is expressed in endothelial cell layers and in tissues undergoing active remodeling. It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains.
Blood-coagulation factor VIII. Antihemophilic factor that is part of the factor VIII/von Willebrand factor complex. Factor VIII is produced in the liver and acts in the intrinsic pathway of blood coagulation. It serves as a cofactor in factor X activation and this action is markedly enhanced by small amounts of thrombin.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
An x-linked recessive hepatic glycogen storage disease resulting from lack of expression of phosphorylase-b-kinase activity. Symptoms are relatively mild; hepatomegaly, increased liver glycogen, and decreased leukocyte phosphorylase are present. Liver shrinkage occurs in response to glucagon.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A layer of the cornea. It is the basal lamina of the CORNEAL ENDOTHELIUM (from which it is secreted) separating it from the CORNEAL STROMA. It is a homogeneous structure composed of fine collagenous filaments, and slowly increases in thickness with age.
The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.
Enzymes that catalyze the degradation of collagen by acting on the peptide bonds.
A member of the MATRIX METALLOPROTEINASES that cleaves triple-helical COLLAGEN types I, II, and III.
A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.
A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.
An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.
The mechanical process of cooling.
Insurance designed to compensate persons who lose wages because of illness or injury; insurance providing periodic payments that partially replace lost wages, salary, or other income when the insured is unable to work because of illness, injury, or disease. Individual and group disability insurance are two types of such coverage. (From Facts on File Dictionary of Health Care Management, 1988, p207)
An independent agency within the Executive Branch of the United States Government. It administers a national social insurance program whereby employees, employers, and the self-employed pay contributions into pooled trust funds. Part of the contributions go into a separate hospital insurance trust fund for workers at age 65 to provide help with medical expenses. Other programs include the supplemental social security income program for the aged, blind, and disabled and the Old Age Survivors and Disability Insurance Program. It became an independent agency March 31, 1995. It had previously been part of the Department of Health, Education, and Welfare, later the Department of Health and Human Services. (From United States Government Manual, 1994-95)
Government sponsored social insurance programs.
A plant genus of the family LINACEAE that is cultivated for its fiber (manufactured into linen cloth). It contains a trypsin inhibitor and the seed is the source of LINSEED OIL.
The fixed oil obtained from the dried ripe seed of linseed, Linum usitatissimum (L. Linaceae). It is used as an emollient in liniments, pastes, and medicinal soaps, and in veterinary medicine as a laxative. It is also called flaxseed oil. (Dorland, 28th ed)
Disorder caused by loss of endothelium of the central cornea. It is characterized by hyaline endothelial outgrowths on Descemet's membrane, epithelial blisters, reduced vision, and pain.
Bilateral hereditary disorders of the cornea, usually autosomal dominant, which may be present at birth but more frequently develop during adolescence and progress slowly throughout life. Central macular dystrophy is transmitted as an autosomal recessive defect.
Single layer of large flattened cells covering the surface of the cornea.
A surgical procedure or KERATOPLASTY involving selective stripping and replacement of diseased host DESCEMET MEMBRANE and CORNEAL ENDOTHELIUM with a suitable and healthy donor posterior lamella. The advantage to this procedure is that the normal corneal surface of the recipient is retained, thereby avoiding corneal surface incisions and sutures.
Partial or total replacement of all layers of a central portion of the cornea.
A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
The functions and properties of living organisms, including both the physical and chemical factors and processes, supporting life in single- or multi-cell organisms from their origin through the progression of life.
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Exclusive legal rights or privileges applied to inventions, plants, etc.
Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
Basic glycoprotein members of the SERPIN SUPERFAMILY that function as COLLAGEN-specific MOLECULAR CHAPERONES in the ENDOPLASMIC RETICULUM.
ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Water-soluble proteins found in egg whites, blood, lymph, and other tissues and fluids. They coagulate upon heating.
Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.
Creation and development of bodies within solar systems, includes study of early planetary geology.
A non-fibrillar collagen involved in anchoring the epidermal BASEMENT MEMBRANE to underlying tissue. It is a homotrimer comprised of C-terminal and N-terminal globular domains connected by a central triple-helical region.
Form of epidermolysis bullosa characterized by trauma-induced, subepidermal blistering with no family history of the disease. Direct immunofluorescence shows IMMUNOGLOBULIN G deposited at the dermo-epidermal junction.
Form of epidermolysis bullosa characterized by atrophy of blistered areas, severe scarring, and nail changes. It is most often present at birth or in early infancy and occurs in both autosomal dominant and recessive forms. All forms of dystrophic epidermolysis bullosa result from mutations in COLLAGEN TYPE VII, a major component fibrils of BASEMENT MEMBRANE and EPIDERMIS.
Group of genetically determined disorders characterized by the blistering of skin and mucosae. There are four major forms: acquired, simple, junctional, and dystrophic. Each of the latter three has several varieties.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Visible accumulations of fluid within or beneath the epidermis.

Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial dystrophy. (1/44)

Corneal clarity is maintained by its endothelium, which functions abnormally in the endothelial dystrophies, leading to corneal opacification. This group of conditions includes Fuchs' endothelial dystrophy of the cornea (FECD), one of the commonest indications for corneal transplantation performed in developed countries, posterior polymorphous dystrophy (PPCD) and the congenital hereditary endothelial dystrophies (CHED). A genome-wide search of a three-generation family with early-onset FECD demonstrated significant linkage with D1S2830 (Z(max) = 3.72, theta = 0.0). Refinement of the critical region defined a 6-7 cM interval of chromosome 1p34.3-p32 within which lies the COL8A2 gene. This encodes the 703 amino acid alpha2 chain of type VIII collagen, a short-chain collagen which is a component of endothelial basement membranes and which represented a strong candidate gene. Analysis of its coding sequence defined a missense mutation (gln455lys) within the triple helical domain of the protein in this family. Mutation analysis in patients with FECD and PPCD demonstrated further missense substitutions in familial and sporadic cases of FECD as well as in a single family with PPCD. This is the first description of the molecular basis of any of the corneal endothelial dystrophies or of mutations in type VIII collagen in association with human disease. This suggests that the underlying pathogenesis of FECD and PPCD may be related to disturbance of the role of type VIII collagen in influencing the terminal differentiation of the neural crest derived corneal endothelial cell.  (+info)

Upregulation of collagen VIII following porcine coronary artery angioplasty is related to smooth muscle cell migration not angiogenesis. (2/44)

Type VIII collagen is upregulated after vessel injury, and this collagen has been implicated in both smooth muscle cell migration and angiogenesis. This study examines the temporal and spatial pattern of expression of type VIII collagen in porcine coronary vessels at specific time points after balloon angioplasty. In situ hybridization studies demonstrated that collagen VIII messenger ribonucleic acid (mRNA) was markedly elevated in the neoadventitia at 3 days post-angioplasty. By 14 days, elevated collagen VIII message was seen mainly in the neointima and this expression decreased to background levels by 90 days. The distribution of collagen VIII protein, detected using immunohistochemistry, was similar but the up-regulation lagged behind the mRNA increase by a few days. Pre-treatment of sections with pepsin highlighted variations in the organization and appearance of extracellular collagen VIII containing structures in both injured and normal vessels. New vessel formation was evident in the neoadventitia after 3 days, but there was no colocalization of type VIII collagen immunostaining with that of von Willebrand factor (a marker of endothelial cells) in the neoadventitia. These data show that up-regulation of collagen VIII in the neoadventitia is an important early marker of the coronary arterial response to injury, and is not associated with new vessel formation.  (+info)

Human corneal epithelial cell viability and morphology after dilute alcohol exposure. (3/44)

PURPOSE: To determine the effect of dilute alcohol on human corneal epithelial cellular morphology and viability. Dilute alcohol is used for epithelial removal during photorefractive keratectomy (PRK) and laser subepithelial keratomileusis (LASEK). METHODS: Corneal epithelial sheets harvested from human eyes after alcohol application during PRK were examined by light and electron microscopy (specimens I-IV). In addition, tissue cultures of human epithelial sheets were monitored for epithelial migration and attachment (specimens V-VII). To determine the effect of dilute alcohol on epithelial cell viability, simian virus (SV)40-immortalized human corneal epithelial cells were exposed to dilute alcohol in distilled water (EtOH-H2O) or to keratinocyte serum-free medium (EtOH-KSFM) for incubation periods of 20 to 45 seconds and concentrations of 10% to 70%. Cell membrane permeability and intracellular esterase activity were analyzed by calcein-acetoxymethyl ester (AM)/ethidium homodimer assay. TdT-mediated dUTP nick-end labeling (TUNEL) assay was used to detect apoptotic cells at 0, 8,12, 24, and 72 hours. RESULTS: Electron microscopy showed varying degrees of basement membrane alterations after alcohol application, including disruptions, discontinuities, irregularities, and duplication (specimens I-IV). Cellular destruction and vacuolization of basal epithelial cells associated with absent basement membrane were also observed (specimen III). One of three cultured epithelial sheets showed attachment and outgrowth in the tissue culture until day 15 (specimen V). Twenty-second exposure of cultured immortalized human cells to various concentrations of EtOH-H2O showed significant reduction of viable cells when EtOH-H2O concentration exceeded 25% (P = 0.005). Increasing the duration of application of 20% EtOH-H2O beyond 30 seconds resulted in a significant reduction in viable cells (69.69% +/- 16.34% at 30 seconds compared with 2.14% +/- 2.29%, 10.45% +/- 7.11%, and 11.09% +/- 15.73% at 35, 40, and 45 seconds, respectively; P = 0.01). TUNEL assay of cultured human corneal epithelial cells exposed to 20% EtOH-H(2)O for 20 and 40 seconds showed maximal labeling at 24 hours (58.05% +/- 33.10%) and 8 hours (94.12% +/- 1.21%), respectively. Exposure to 20% EtOH-KSFM for 20 and 40 seconds resulted in substantially lower TUNEL positivity (3.51% +/- 0.20% at 24 hours and 7.11% +/- 0.49% at 8 hours). CONCLUSIONS: The viability and electron microscopic findings in the basement membrane zone showed significant variation after treatment of the epithelium in vivo with dilute alcohol. The application of dilute alcohol on the monolayer of cultured corneal epithelial cells resulted in increasing cell death in a dose- and time-dependent manner.  (+info)

Estrogen receptor specificity for the effects of estrogen in ovariectomized mice. (4/44)

Estrogen exerts a variety of important physiological effects, which have been suggested to be mediated via the two known estrogen receptors (ERs), alpha and beta. Three-month-old ovariectomized mice, lacking one or both of the two estrogen receptors, were given estrogen subcutaneously (2.3 micro g/mouse per day) and the effects on different estrogen-responsive parameters, including skeletal effects, were studied. We found that estrogen increased the cortical bone dimensions in both wild-type (WT) and double ER knockout (DERKO) mice. DNA microarray analysis was performed to characterize this effect on cortical bone and it identified four genes that were regulated by estrogen in both WT and DERKO mice. The effect of estrogen on cortical bone in DERKO mice might either be due to remaining ERalpha activity or represent an ERalpha/ERbeta-independent effect. Other effects of estrogen, such as increased trabecular bone mineral density, thymic atrophy, fat reduction and increased uterine weight, were mainly ERalpha mediated.  (+info)

Identification of genes induced in regenerating Xenopus tadpole tails by using the differential display method. (5/44)

To identify candidate gene(s) involved in the tail regeneration of Xenopus laevis tadpoles, we used the differential display method to isolate four genes (clones 1, 2, 13a, and 13b) whose expression is induced in regenerating tadpole tails. Among them, clones 13a and 13b were found to encode the Xenopus homologues of the alpha1 chain of type XVIII collagen and neuronal pentraxin I, respectively. Expression of clone 2 and neuronal pentraxin I genes increased dramatically in the blastema 3 days after amputation, whereas that for the clone 1 and type XVIII collagen genes was induced gradually after amputation. In situ hybridization revealed that the neuronal pentraxin I gene is expressed specifically in the regenerating tail epidermis but not in the normal tail epidermis or the most distal margin of the tail blastema, suggesting that it has a tissue-inductive role in tail regeneration. Expression of the four genes was induced in the limb and in the tail blastema, suggesting that they are involved in the regeneration of both organs. Finally, expression of clone 2 and neuronal pentraxin I genes was scarce during embryonic stages in comparison to the tail blastema, suggesting that their main functions are in organ regeneration. Our results demonstrate unique features of spatial and temporal gene expression patterns during Xenopus tadpole tail regeneration.  (+info)

Molecular targets for tumour progression in gastrointestinal stromal tumours. (6/44)

BACKGROUND AND AIMS: The distinction between benign and malignant gastrointestinal stromal tumours (GISTs) is often unclear at the clinical and histopathology levels. GISTs are believed to arise from the stem cells of Cajal. In order to define genetic biomarkers and identify target genes related to GIST progression, we analysed and compared benign and malignant GISTs with verified follow up data using cDNA expression arrays. METHODS: Eight genes were frequently overexpressed in malignant GISTs and their overexpression was confirmed using quantitative real time reverse transcription-polymerase chain reaction. These genes included ezrin (villin 2 (VIL2)), collagen 8 alpha 1 subunit (COL8A1), G2/mitotic specific cyclin B1 (CCNB1), high mobility group protein (HMG2), TSG101 tumour susceptibility protein, CENP-F kinetochore protein, protein tyrosine kinase 2 (FAK), and protein kinase DYRK2. To test these genes in a clinical setting, we obtained diagnostic samples of 16 additional GISTs that were classified at diagnosis as benign, malignant, and uncertain malignant potential (UMP). RESULTS: There was remarkable gene overexpression in all malignant GISTs. Statistical analyses revealed significant correlations between overexpression of several gene pairs in malignant GISTs. We found the strongest correlations (rho>0.70) among the significant correlations (p<0.01) between CCNB1-CENP-F (rho = 0.87) and CCNB1-FAK (rho = 0.73). Gene expression of the UMP GISTs suggested two different groups. Three UMP GISTs had gene expression consistent with malignant tumours and their follow up data revealed that indeed these patients had recurrences later on. On the other hand, UMP GISTs that had low gene expression levels continued free of disease for several years. CONCLUSIONS: These results provide insight into the oncogenesis of GISTs and suggest that testing the expression profile of a number of genes may segregate GISTs into groups of different tumour behaviour.  (+info)

Expression and supramolecular assembly of recombinant alpha1(viii) and alpha2(viii) collagen homotrimers. (7/44)

Collagen VIII is an extracellular matrix macromolecule comprising two polypeptide chains, alpha1(VIII) and alpha2(VIII), that can form homotrimers in vitro and in vivo. Here, recombinant collagen VIII was expressed to study its supramolecular assembly following secretion. Cells transfected with alpha1(VIII) or alpha2(VIII) assembled and secreted homotrimers that were stable in denaturing conditions and had a molecular mass of approximately 180 kDa on SDS-PAGE gels. Co-transfection with prolyl 4-hydroxylase generated homotrimers with stable pepsin-resistant triple-helical domains. Size fractionation of native recombinant collagen VIII molecules expressed with or without prolyl 4-hydroxylase identified urea-sensitive high molecular mass assemblies eluting in the void volume of a Superose 6HR 10/30 column and urea-resistant assemblies of approximately 700 kDa, all of which were composed of homotrimers. Immunofluorescence analysis highlighted the extracellular deposition of recombinant alpha1(VIII)(3), alpha2(VIII)(3), and co-expressed alpha1(VIII)(3)/alpha2(VIII)(3). Microscopy analysis of recombinant collagen VIII identified rod-like molecules of 134 nm in length that assembled into angular arrays with branching angles of approximately 114 degrees and extensive networks. Based on these data, we propose a model of collagen VIII assembly in which four homotrimers form a tetrahedron stabilized by central interacting C-terminal NC1 trimers. Tetrahedrons may then act as building blocks of three-dimensional hexagonal lattices generated by secondary interactions involving terminal and helical sequences.  (+info)

Endostatin promotes the anabolic program of rabbit chondrocyte. (8/44)

Endostatin is a natural occurred angiogenesis inhibitor derived from collagenXVIII. So far its function during the angiogenesis process of bone formation and arthropathy has not been well studied yet. The present study addresses the function of endostatin in rabbit articular chondrocytes (RAC). We found that endostatin can promote RAC adhesion and spreading as well as its proliferation. In monolayer cultured RAC, CollagenII, TIMP1 and collagenXVIII transcription were up regulated by endostatin while collagenI and MMP9 were down regulated. Moreover collagenXVIII and endostatin antigens are present at synovial fluid. These findings indicate new function of endostatin as a homeostatic factor in cartilage metabolism.  (+info)

TY - JOUR. T1 - Collagen VIII is expressed by vascular smooth muscle cells in response to vascular injury. AU - Sibinga, Nicholas E S. AU - Foster, Lauren C.. AU - Hsieh, Chung Ming. AU - Perrella, Mark A.. AU - Lee, Wen Sen. AU - Endege, Wilson O.. AU - Sage, E. Helene. AU - Lee, Mu En. AU - Haber, Edgar. PY - 1997. Y1 - 1997. N2 - To identify genes involved in vascular remodeling, we applied differential mRNA display analysis to the rat carotid artery balloon injury model. One polymerase chain reaction product showing increased expression at days 2 to 14 after vascular injury was nearly identical to the mouse α1 chain of type VIII collagen, a heterotrimeric short-chain collagen of uncertain function expressed by a limited number of cell types. By Northern analysis, expression of both chains of the type VIII collagen heterotrimer increased: collagen α1 (VIII) mRNA expression was almost 4-fold higher than control by 7 days after vascular injury, and collagen α2 (VIII) mRNA expression reached ...
Collagen VIII alpha 1兔多克隆抗体(ab100988)可与人样本反应并经WB实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets.
View mouse Col8a2 Chr4:126286793-126314330 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
Mehta, J.S., Vithana, E.N., Tan, D.T.H., Yong, V.H.K., Aung, T., Yam, G.H.F., Law, R.W.K., Pang, C.P. (2008). Analysis of the posterior polymorphous corneal dystrophy 3 gene, TCF8, in late-onset fuchs endothelial corneal dystrophy. Investigative Ophthalmology and Visual Science 49 (1) : 184-188. [email protected] Repository. https://doi.org/10.1167/iovs.07- ...
Purpose : Fuchs endothelial corneal dystrophy (FECD) is an autosomal dominant disease with assorted variations in expression and penetrance. The expansion of a CTG trinucleotide repeat (TNR) in a different intron of transcription factor 4 (TCF4) has commonly been detected in FECD patients, and the sensitivity and specificity of ,50 repeats was 79% and 96%, respectively (Wieben et al., PloS ONE, 2012). The purpose of this present study was to evaluate the TNR expansion in a larger cohort of Caucasian FECD patients. Methods : We recruited 387 FECD patients (158 males and 229 females; mean age: 69.7±9.2 years; range: 32-92 years) who were scheduled to receive Descemets membrane endothelial keratoplasty (DMEK) at the University of Erlangen-Nürnberg Hospital in order to obtain peripheral blood samples. All patients were diagnosed as FECD due to symptoms such as guttae, corneal edema, and decrease of corneal endothelial cell density. Purification of genomic DNA from each patients blood sample was ...
Purpose : Fuchs Endothelial Corneal Dystrophy (FECD) is a late-onset oxidative stress-induced disease characterized by progressive loss of corneal endothelial cells. We previously reported increased mitochondrial fragmentation as a possible phenomenon that explained the pathomechanism of FECD. The aim of this study is to further decipher the key checkpoints involved in mitochondrial quality control that may be aberrantly regulated in FECD. Methods : Tissue lysates prepared from post-keratoplasty specimens from late-onset FECD cases were compared with age-matched normal donor specimens (n=3 for each group) for PINK1, phosphoParkin(Ser65), phospho-Drp1(Ser616), phosphoDrp1(Ser637). Whole cell lysates of human corneal endothelial cell line immortalized with hTert (HCEnC-21T) were treated with 50mM menadione (MN) and 10nM Bafilomycin A1 for 20 hours. HCEnC-21T cells were transfected with YFP-Parkin, fragmentation was induced with 50mM MN, and mitochondria were visualized with immunofluorescence ...
Fuchs endothelial corneal dystrophy (FECD) MIM#136800 and posterior polymorphous corneal dystrophy (PPCD) MIM#122000 both belong to the corneal endothelial dystrophies in which endothelial dysfunction can lead to corneal oedema. In addition, they both share the common features of endothelial metaplasia and the secretion of an abnormal Descemets membrane as a pathological posterior collagenous layer (PCL) with a small or absent posterior non-banded zone.1,2. The exact cause of both FECD and PPCD is still unknown, although both are thought to be the result of a disorder of neural crest terminal differentiation.3 Mutations in COL8A2, the gene for the α2(VIII) chain of type VIII collagen, have previously been described in patients with both FECD and PPCD,4,5 and type ...
Arch Ophthalmol. 2012 Apr;130(4):433-9. doi: 10.1001/archopthalmol.2011.1626. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt
Expertise, Disease and Conditions: Cataract Surgery, Cataracts, Cornea Transplant, Cornea/Anterior Segment Disease, Corneal Disorders, Corneal Dystrophies, Corneal Ulcer, Dry Eyes, Fuchs Dystrophy of the Cornea, Fuchs Endothelial Corneal Dystrophy, Herpes Infections, Keratoconus, Laser Surgery, Ophthalmology, Refractive Surgery, Thyroid Eye Disease, ...
Researchers at Mayo Clinic have identified the specific genetic defect in the TCF4 gene - the expansion of the TGC repeat - that appears to be responsible for Fuchs endothelial corneal dystrophy (FECD).
Adiponectin, also referred to as Acrp30, AdipoQ and GBP-28, is a recently discovered 244 amino acid protein, the product of the apM1 gene, which is physiologically active and specifically and highly expressed in adipose cells (adipokine). The protein belongs to the soluble defence collagen superfamily; it has a collagen-like domain structurally homologous with collagen VIII and X and complement factor C1q-like globular domain. Adiponectin forms homotrimers, which are the building blocks for higher order complexes found circulating in serum. The human Adiponectin is expressed in E. coli as a recombinant 25.1 kDa sinle, non-glycosylated polypeptide chain containing 231 amino acid residues ...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Polyglutamylation is a reversible posttranslational modification catalyzed by polyglutamylases that results in the addition of glutamate side chains on the modified protein. This gene encodes a glutamate decarboxylase that catalyzes the deglutamylation of polyglutamylated proteins. Mutations in this gene result in dominant late-onset Fuchs corneal dystrophy. [provided by RefSeq, Nov 2013 ...
RecName: Full=Adenylate cyclase type 8; EC=4.6.1.1;AltName: Full=Adenylate cyclase type VIII;AltName: Full=ATP pyrophosphate-lyase 8;AltName: Full=Adenylyl cyclase 8;AltName: Full=Ca(2+)/calmodulin-activated adenylyl ...
Data scientist Thomas Fuchs develops and applies advanced machine learning and computer vision techniques for tackling large-scale computational pathology challenges in cancer research and clinical practice.
Kerstin Fuchs is the author of this article in the Journal of Visualized Experiments: Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent
PURPOSE: To investigate the functional role that the zinc e-box binding homeobox 1 (ZEB1) gene, which underlies the genetic basis of posterior polymorphous corneal dystrophy 3 (PPCD3), plays in corneal endothelial cell proliferation, apoptosis, migration, and barrier function. METHODS: A human corneal endothelial cell line (HCEnC-21T) was transfected with siRNA targeting ZEB1 mRNA. Cell proliferation, apoptosis, migration, and barrier assays were performed: Cell proliferation was assessed with cell counting using a hemocytometer; cell apoptosis, induced by either ultraviolet C (UVC) radiation or doxorubicin treatment, was quantified by measuring cleaved caspase 3 (cCASP3) protein levels; and cell migration and barrier function were monitored with electric cell-substrate impedance sensing (ECIS ...
Findings published in the American Journal of Pathology offer new directions for treatment of patients with Fuchs Endothelial Corneal Dystrophy (FECD)
Do You Have Corneal Dystrophy, Fuchs Endothelial, 1? Join friendly people sharing true stories in the I Have Corneal Dystrophy, Fuchs Endothelial, 1 group. Find support forums, advice and chat with groups who share this life experience. A Corneal D...
From iuvax!bionet!embl.bitnet!FUCHS Mon Jun 25 09:29:36 EST 1990 Article 347 of bionet.software: Path: iuvax!bionet!embl.bitnet!FUCHS >From: [email protected] (Rainer Fuchs , EMBL Data Library) Newsgroups: bionet.software Subject: Molecular biological software/EMBL File Server Message-ID ...
Buy Fuchs «Extra» online: this off-dry red wine is very dense and has a fine fruitiness with a touch of sweetness. Histamine content 0.228 mg/l.
Pepperl+Fuchs offers a broad range of technologies to support your applications. Choose products and services that include SIL (safety integrity level), fieldbus advanced diagnostics and software solutions, or wireless HART communication
TY - JOUR. T1 - Evaluation of phacoemulsification-induced oxidative stress and damage of cultured human corneal endothelial cells in different solutions using redox fluorometry microscopy. AU - Nishi, Yutaro. AU - Engler, Christoph. AU - Na, Dae Ro. AU - Kashiwabuchi, Renata T.. AU - Shin, Young Joo. AU - Cano, Marisol. AU - Jun, Albert S.. AU - Chuck, Roy S.. PY - 2010/12/1. Y1 - 2010/12/1. N2 - Purpose: To describe the basic concept of redox fluorometry microscopy and investigate its efficacy in evaluating the state of cultured human corneal endothelial cells in different solutions when ultrasonic energy was applied in vitro. Methods: Human corneal endothelial cells from human donor tissue not suitable for transplantation were cultured. A phacoemulsification probe with a 30° round, 1.1- mm TurboSonics® ABS™ Tip (Alcon, Fort Worth, Texas) was introduced into culture dishes filled with balanced salt solution (BSS) and BSS plus (Alcon, Fort Worth, Texas). Cellular autofluorescence images were ...
Trappist Westvleteren 8 (VIII) is a Dubbel style beer brewed by Brouwerij Westvleteren (Sint-Sixtusabdij van Westvleteren) in Westvleteren, Belgium. 4.48 average with 2197 ratings, reviews and opinions.
Trappist Westvleteren 8 (VIII) is a Dubbel style beer brewed by Brouwerij Westvleteren (Sint-Sixtusabdij van Westvleteren) in Westvleteren, Belgium. 4.48 average with 2198 ratings, reviews and opinions.
Alport syndrome (AS) is characterized by renal, cochlear, and ocular involvement. In the absence of treatment, renal disease progresses from microscopic hematuria to proteinuria, progressive renal insufficiency, and end-stage renal disease (ESRD) in all males with X-linked (XL) AS, and in all males and females with autosomal recessive (AR) AS. Progressive sensorineural hearing loss (SNHL) is usually present by late childhood or early adolescence. Ocular findings include anterior lenticonus (which is virtually pathognomonic), maculopathy (whitish or yellowish flecks or granulations in the perimacular region), corneal endothelial vesicles (posterior polymorphous dystrophy), and recurrent corneal erosion. In individuals with autosomal dominant (AD) AS, ESRD is frequently delayed until later adulthood, SNHL is also relatively late in onset and ocular involvement is rare. Thin basement membrane nephropathy (TBMN) is characterized by persistent microscopic hematuria often first observed in childhood; ...
Visual system homeobox 1 is a protein that in humans is encoded by the VSX1 gene. The protein encoded by this gene contains a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior polymorphous corneal dystrophy (PPCD) and keratoconus. Two transcript variants encoding different isoforms have been found for this gene. GRCh38: Ensembl release 89: ENSG00000100987 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000033080 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Semina EV, Mintz-Hittner HA, Murray JC (Apr 2000). Isolation and characterization of a novel human paired-like homeodomain-containing transcription factor gene, VSX1, expressed in ocular tissues. Genomics. 63 (2): 289-93. doi:10.1006/geno.1999.6093. PMID 10673340. Entrez Gene: VSX1 visual system homeobox ...
Your cornea is the clear part of the front of the eye. Corneal dystrophies are common genetic conditions which cause changes to your cornea without any inflammation, infection or other eye disease. Corneal dystrophies affect the clearness of your cornea and usually involve both eyes. Although they can often get worse over time, normally this happens very slowly. Many corneal dystrophies develop so slowly that they may never get to a point where they affect your vision.
Corneal dystrophy comes in more than 20 types and occurs when material piles up in at least one of the five layers of the cornea. Corneal dystrophy can cause the cornea to lose its clarity, with the...
Pepperl+Fuchs is a pioneer and innovator of industrial sensors for factory automation and an expert for explosion protection in process automation
Alfonso VIII o Fernando II (hacia 1170). Dinero. Vellón. Sin marca de ceca. Figura de Fernando II coronado y estante a derecha S delante seguida por la de Alfonso VIII de niño y ·ALFOVN· con anillos al principio y final de la leyenda, cruz sobre menguante y dos puntos en el tercer y cuarto cuartel de la cruz y FRNANDVS REX con la S tumbada. RV119 de Alfonso VIII. Cy1048 de Alfonso VIII. AB158 de Alfonso VIII. 0´55 g. Algo sucia. MBC-. Estimación 600 €
GAINESVILLE Wednesday evening, hazy rumors of an impending Neo-Nazi march reached some wary protesters. A few quickly rallied to denounce the marchers in downtown Gainesville, only to find plazas e
Daniela Zühlke, Kirsten Dörries, Jörg Bernhardt, Sandra Maaß, Jan Muntel, Volkmar Liebscher, Jan Pané-Farré, Katharina Riedel, Michael Lalk, Uwe Völker, Susanne Engelmann, Dörte Becher, Stephan Fuchs, Michael Hecker ...
This Histri was built automatically but not manually verified. As a consequence, the Histri can be incomplete or can contain errors ...
Fuchs Dystrophy is a type of corneal disease that affects the inner most layer of the cornea-the endothelium. Fuchs Dystrophy is slowly progressive, is found in both eyes and is slightly more common in women than men. While we can see Fuchs Dystrophy in people in their 30s and 40s, it usually does not compromise vision until people are in their 50s or 60s.. About Fuchs Dystrophy. The endothelial cells are responsible for pumping water out of the cornea and helping to maintain the corneal transparency. While the reason is poorly understood, in Fuchs Dystrophy, the endothelial cells die, which make the endothelium less efficient in its pumping activity. This results in the cornea swelling and distorting vision. Fuchs Dystrophy Risks & Severity. Researchers reporting in the journal Investigative Ophthalmology and Visual Science studied the effects of smoking, and other risk factors, on the development of advanced Fuchs endothelial corneal dystrophy (FECD) and on central corneal thickness ...
Looking for information on Dog Corneal Dystrophy (Corneal Opacities) in Manchester? We have compiled a list of businesses and services around Manchester that should help you with your search. We hope this page helps you find information on Dog Corneal Dystrophy (Corneal Opacities) in Manchester.
Looking for information on Dog Corneal Dystrophy (Corneal Opacities) in Stamford? We have compiled a list of businesses and services around Stamford that should help you with your search. We hope this page helps you find information on Dog Corneal Dystrophy (Corneal Opacities) in Stamford.
PURPOSE: To report the presence of the R124H mutation in two Spanish families with Avellino corneal dystrophy (ACD). METHODS: Two families with subjects who presented biomicroscopic features of ACD were included in this study. They have no relatives
Pharmacist Ben Fuchs radio show archives. Ben Fuchs archive is a directory of all the Bright Side Ben radio show broadcasts produced by the Genesis Communications Network - GCN, Youngevity and DR Joel Wallach
Pharmacist Ben Fuchs radio show archives. Ben Fuchs archive is a directory of all the Bright Side Ben radio show broadcasts produced by the Genesis Communications Network - GCN, Youngevity and DR Joel Wallach
If you are 70½ years old or older, you can make a tax free donation via your IRA to youir favorite charity Read More. Covered California Current members can renew or change their health plans until Jan. 31, 2018. Coverage now will start March 1, 2018. All other states are now closed. Please copy and paste to circulate.. ...
Machado Y., R. Freier, S. Scheiblhofer, T. Thalhamer, M. Mayr, P. Briza, S. Grutsch, L. Ahammer, J. E. Fuchs, H. G. Wallnoefer, A. Isakovic, V. Kohlbauer, A. Hinterholzer, M. Steiner, M. Danzer, J. Horejs-Hoeck, F. Ferreira, K. R. Liedl, M. Tollinger, P. Lackner, C. M. Johnson, H. Brandstetter, J. Thalhamer and R. ...
Study VIII - Environmental and Nutritional Diseases flashcards from Vanessa Almaden's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
Study VIII - Environmental and Nutritional Diseases flashcards from Valerie Queyquep's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
Unusual giant nodules on the posterior surface of Descemets membrane were observed in two out of over 400 corneae examined during routine histopathological reporting. Both of the patients, a 60-year-old man and a 26-year-old woman, had histories of corneal trauma. Neither was associated with chronic keratitis or corneal dystrophy. Light microscopy showed these nodules to be composed of material resembling Descemets membrane. Histochemical and electron microscopical preparations identified oxytalan fibres within the outer layers of the nodules. These fibres are not a feature of the normal adult Descemets membrane. The findings are discussed and compared with other nodular lesions of Descemets membrane. ...
Baburajeev, C. P. and Mohan, C. D. and Shobith, R. and Mason, Daniel J. and Fuchs, Julian E. and Bender, Andreas and Barash, Uri and Vlodavsky, Israel and Rangappa, K. S. (2017) Identification of novel class of triazolo-thiadiazoles as potent inhibitors of human heparanase and their anticancer activity. BMC Cancer, 17 (1). pp. 1-14. ISSN 1471-2407 Anusha Sebastian, and Pandey, Vijay and Mohan, C. D. and Chia, Yi Ting and Shobith, R. and Mathai, Jessin and Baburajeev, C. P. and Paricharak, Shardul and Mervin, Lewis H. and Bulusu, Krishna C. and Fuchs, Julian E. and Bender, Andreas and Yamada, Shuhei and Basappa, and Lobie, Peter E. and Rangappa, K. S. (2016) Novel adamantanyl-based thiadiazolyl pyrazoles targeting EGFR in triple-negative Breast Cancer. ACS Omega, 1 (6). pp. 1412-1424. ISSN 2470-1343 Gowtham, S. and Babu Rajeev, C. P. and Mohan, C. D. and Sinha, Ameya and Chu, Trang T. T. and Sebastian Anusha, and Ximei, Huang and Fuchs, Julian E. and Bender, Andreas and Rangappa, K. S. and ...
Mutations in human and/or mouse homologs are associated with this disease. Synonyms: FCD; Francois-Neetens speckled corneal dystrophy
Gabriel Fuchs is a senior consultant and business intelligence expert. His column Reality IT takes an ironic look at what real-world IT solutions often look like - for better or for worse. The ideas and thoughts expressed in this column are based on Fuchs own personal experience and imagination and do not reflect the situation at any particular company. His book, Dealing with Nasty Colleagues: The Art of Winning in Office Politics While Still Getting the Job Done, can be ordered at www.amazon.co.uk. He can be reached at [email protected]
Enjoy the lowest prices and best selection of Fuchs Solid State Bass Amplifier Heads at Guitar Center. Most orders are eligible for free shipping!
Schematic of proposed mechanism of TGFBI-related corneal dystrophies in present study. The hypothesis of pathogenesis of TGFBI-related corneal dystrophies mainl
Free, official information about 2014 (and also 2015) ICD-9-CM diagnosis code 371.52, including coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion.
One of the positive points of this database is that it has high organization and facilitates the user towards pertinent databases as well as thoroughly describe the mission/initiative of the database. Additionally, this database has attempted to consolidate multiple country hosted databases and makes it free for public use. However only one of the databases is secure in the form of https and it would be comforting for researchers to access more secure sites when collecting critical information ...
myotcstore.com - Buy over the counter medicines, vitamins, feminine needs, household and baby care items online at discount prices. Earn Reward Points on every purchase.
The scenario that the Gemara describes in Berachos 21a discusses the halacha when one is in the middle of davening Shemoneh Esrei and realizes that he had already davened this tefillah. The Gemara says that he should stop davening immediately, even if he is in the middle of a berachah. Even though one may daven a tefillas nedavah (a voluntary tefillah) whenever he desires, he must stop in the middle since he initially began davening under the impression that the tefillah was obligatory. The Tosafos Harash explains that just as there are no korbanos that are part obligatory and part voluntary, so too there cannot be a tefillah that is part obligatory and part voluntary.. Based on this, the Rambam (Hilchos Tefillah 10:6) wrote a tremendous chiddush. He wrote that the abovementioned Gemara - that discusses the halacha concerning ones realization in the middle of Shemoneh Esrei that he has already davened that tefillah - should not apply when the tefillah that one is in the midst of reciting is ...
Global Specialty Lubricants market report 2018 provides analysis based on vendors, types, applications and presents upcoming industry trends.
For COM.POST #15 Raymond Dijkstra curated an exclusive live program with new acoustic compositions to be made on the spot in a blind date setting. With public reader Frédérique Bruyas (fr), composer of acoustic and visual happenings Limpe Fuchs (de) , soundartist Timo van Luijk/Af Ursin (fin/be) & Edward Ka-spel (uk/nl) who is known from The Legendary Pink Dots o=Raymond
Université de Liège - ULg , Département de langues et littératures romanes , Langues et littératures espagnoles et hispano-américaines ,] ...
一种低碳醇合成异丁醛催化剂的方法,涉及一种合成催化剂的方法,包括以下过程:将可溶性钒盐和IVB、VB、VIII中的一种或两种金属可溶盐分别溶于水溶液中,然后加入水热反应釜中,水热处理2‑12h,离心分离,水洗、乙醇洗,进一步在烘箱中干燥,其干燥温度为80‑150℃;得到固体催化剂;将合成的固体催化剂通过氮气、水蒸气和乙醇或丙醇混合气处理1‑4h得到高比表面和独特结构的V‑X氧化物催化剂。该催化剂制备方法简单、重复性好,具有高活性和高选择性,乙醇转化率为95%以上,异丁醛选择性88%以上,产物中除异丁醛外,主要产物为高附加值的乙醛和丙醛和异丁醇,其他副产物少,催化剂稳定性好。
concretis entravessarem rasclats desfrunzeixes desemmandrís paleoplacer caseïficat infringien torcejam regulem trempant desrengués moltonegí [email protected]íemo.org ...
Using type I collagen nanofibers produced via electrospinning, Shih et al. found that the engineered collagen scaffold showed ... Shih YR, Chen CN, Tsai SW, Wang YJ, Lee OK (November 2006). "Growth of mesenchymal stem cells on electrospun type I collagen ... Nonmineralized organic component (i.e. type 1 collagen), mineralized inorganic component (i.e. hydroxyapatite), and many other ... PCL is a type of biodegradable polyester that can be prepared via ring-opening polymerization of ε-caprolactone using catalysts ...
... with type IV collagen. J Biol Chem 1990; 265:17281-4. Paralkar VM, Vukicevic S, Reddi AH. Transforming growth factor beta type ... Transitions in collagen types during matrix-induced cartilage, bone, and bone marrow formation. Proc Natl Acad Sci U S A 1977; ... potentiation and binding to type IV collagen. J Cell Biol 1992; 119:1721-8. Ripamonti U, Ma S, Cunningham NS, Yeates L, Reddi ... Ramachandran, G.N., Reddi, A.H. (Eds.), Biochemistry of Collagen. Plenum Press, New York, NY, 1976. Piez, K.A., Reddi, A.H. ( ...
... is a protein associated with osteogenesis imperfecta type VIII. Leprecan is part of a superfamily of 2OG-Fe(II) ... The complex hydroxylates a single proline residue, Pro986, on collagen chains. Recessive forms of Osteogenesis Imperfecta are ... dioxygenase, along with DNA repair protein AlkB, and disease resistant EGL-9. The enzyme was found to be a type of hydroxylases ... "Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues". PLOS Genetics. 10 (1): e1004121. doi:10.1371/ ...
"Collagen regulation of let-7 in pancreatic cancer involves TGF-β1-mediated membrane type 1-matrix metalloproteinase expression ... "Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens". BMC Genomics. 13: 306. ... untranslated region of KRAS gene predicts response in wild-type KRAS patients with metastatic colorectal cancer treated with ... 42 (8): 1330-3. doi:10.1016/j.biocel.2009.02.023. PMID 20619222. Lee ST, Chu K, Oh HJ, Im WS, Lim JY, Kim SK, Park CK, Jung KH ...
... type IV collagen in the basement membranes of the capillaries, type V collagen in the vascular walls, and type X collagen in ... These include type II collagen in the cartilaginous zones, type III collagen in the reticulin fibres of the vascular walls, ... collagen I 0-10% collagen III 2% collagen IV small amounts of collagens V, VI, and others 15-40% non-collagenous extracellular ... While collagen I makes up most of the collagen in tendon, many minor collagens are present that play vital roles in proper ...
"Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner". Stem Cell Research & ... such as the collagen is produced by fibroblasts, leading to the formation of a permanent fibrotic scar. In response to injury, ... including collagen and glycosaminoglycans. The process is initiated when immune cells such as macrophages release soluble ... 8: 18. doi:10.1186/s13069-015-0035-8. PMC 4591063. PMID 26435749. Mitra A, Luna JI, Marusina AI, Merleev A, Kundu-Raychaudhuri ...
Kawahara E, Oda Y, Katsuda S, Nakanishi I, Aoyama K, Tomita K (1991). "Microfilamentous type VI collagen in the hyalinized ... studies indicate that the hypertrophy of these ligaments may be linked to a fibrotic process associated with increased collagen ... ISBN 978-1-4160-6257-8. Karpman RR, Weinstein PR, Gall EP, Johnson PC (1982). "Lumbar spinal stenosis in a patient with diffuse ...
The main substrates of the gelatinases are type IV collagen and gelatin, and these enzymes are distinguished by the presence of ... All six membrane-type MMPs (No. 14, No. 15, No. 16, No. 17, No. 24, and No. 25) have a furin cleavage site in the pro-peptide, ... These collagens are the major components of bone, cartilage and dentin, and MMPs are the only known mammalian enzymes capable ... 14 has also been shown to cleave fibrillar collagen, and there is evidence that No. 2 is capable of collagenolysis. In MeSH, ...
... especially actomyosin and Type I collagen, which is found in muscle joints.[8] ... The specificity of zingibain's binding ensures predominant hydrolyzation of actomyosin and Type I collagen. ... Zingibain exhibits complex-type N-linked oligosaccharide chains at two residues.[1] Chains are between 5-13 glycosyl units long ... Zingibain is also used to flavor sausages and baked products.[8] Rennet substitute[edit]. For over the past 100 years, ginger ...
Shaffer has type four osteogenesis imperfecta, a condition involving a defect in type 1 collagen, which causes fragile bones ... October 8, 2010. Archived from the original on March 3, 2016. Retrieved September 19, 2015. Giardina, Carolyn; Zakarin, Jordan ... Cericola, Rachel (January 8, 2013). "5 Questions With Frankenweenie Actor Atticus Shaffer". Wired. Retrieved January 14, 2019. ... and short stature; he is 4' 8" (142 cm) tall. Shaffer is a devout Christian, and has a daily Bible study with his mother, ...
These include lysosomal enzymes, collagen α-chains, C-terminal propeptides of type I pro-collagens, and tissue plasminogen ... The fibronectin type II repeat domain is conserved amongst all members of the mannose receptor family. Collagens I-IV bind this ... The C-type CRDs are each separated by linker regions of 10-20 amino acids containing a number of proline residues, whose cyclic ... It is the first member of a family of endocytic receptors that includes Endo180 (CD280), M-type PLA2R, and DEC-205 (CD205). The ...
There are at least eight main types, with type I being the least severe and type II the most severe. Diagnosis is often based ... Type IIC demonstrates thin and longer long bones with thin and beaded ribs. Collagen improperly formed, enough collagen is made ... Mutations in the gene CRTAP causes this type. OI caused by mutation in the gene LEPRE1 is classified as type VIII. Type IX ... There are at least nine different types of OI. Type I is the most common. Symptoms vary from person to person. Collagen is of ...
Immunohistochemical staining of basement membranes of kidney for laminin, collagen type IV, fibronectin, and Goodpasture ... "Regulation of collagen type IV genes is organ-specific: Evidence from a canine model of Alport syndrome". Kidney International ... X-linked hereditary nephritis resulting from a single base mutation in the gene encoding the alpha 5 chain of collagen type IV ... 42 (5): 235-8. doi:10.1111/j.1748-5827.2001.tb02027.x. PMID 11380016. Zheng, Keqin; Perry, Julie; Harvey, Scott J; Sado, ...
The snake C-type lectin convulxin was reported to activate platelets in a similar way to collagen in the late 1970s, but this ... Platelets interact indirectly with collagen, via the von Willebrand Factor (vWF), which connects the collagen to the platelet ... a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptor". The Journal ... reduced convulxin subunits still inhibit the effect of collagen since they bind to a common receptor necessary for collagen ...
However, this type of pulp stone are rarely seen. The prevalence of pulp stones can reach as high as 50% in surveyed samples ... These layers are made up of blood clots, dead cells and collagen fibres. Occasionally, pulp stones can be seen to be surrounded ... There are two types of nerve fiber that mediate the sensation of pain: A-fibers conduct rapid and sharp pain sensations and ... The A-fibers, mainly of the A-delta type, are preferentially located in the periphery of the pulp, where they are in close ...
The alveolar macrophage is the third cell type in the alveolus, the others are the type I and type II pneumocytes. Alveolar ... IL-4 and IL-10 have both been shown to reduce the production of metalloproteinases (endopeptidases which break down collagen ... The lungs are especially sensitive and prone to damage, thus to avoid collateral damage to type 1 and type II pneumocytes, ... IL-4 is a pleiotropic cytokine that plays a key role in the development of T helper type 2(Th2) cells. IL-4 is important for ...
There was a great need for fast tissue-typing techniques and the work was performed in collaboration with the biotechnology ... Differences in monocyte phenotypes induced by cultivation on glass or on collagen". Journal of Experimental Medicine. 156 (4): ... Together with Professor Frode Vartdal, Gaudernack contributed to the development of cell-isolation systems for tissue-typing ... Chiarandini, DJ; Stefani, E (1979). "Electrophysiological identification of two types of fibres in rat extraocular muscles". ...
Each type of connective tissue in animals has a type of ECM: collagen fibers and bone mineral comprise the ECM of bone tissue; ... Facit (Type IX, XII, XIV). *Short chain (Type VIII, X). *Basement membrane (Type IV) ... Collagen[edit]. Collagens are the most abundant protein in the ECM. In fact, collagen is the most abundant protein in the human ... The collagen can be divided into several families according to the types of structure they form: *Fibrillar (Type I, II, III, V ...
Collagen is exposed at the site of injury, the collagen promotes platelets to adhere to the injury site. Platelets release ... TypesEdit. Hemostasis can be achieved in various other ways if the body cannot do it naturally (or needs help) during surgery ... Some main types of hemostasis used in emergency medicine include: *Chemical/topical- This is a topical agent often used in ... Which hemostasis type used is determined based on the situation.[8]. Developmental Haemostasis refers to the differences in the ...
... its effect on paraproteinemia and the urinary N-telopeptide of type I collagen bone turnover marker". Clinical Cancer Research ... Monoclonal gammopathy of undetermined significance (MGUS) is a plasma cell dyscrasia in which plasma cells or other types of ... 15 (18): 5606-8. doi:10.1158/1078-0432.CCR-09-1575. PMC 2759099. PMID 19737944. Berenson, JR; Anderson, KC; Audell, RA; Boccia ... 112 (8): 3122-5. doi:10.1182/blood-2008-06-164228. PMC 2569167. PMID 18669874. Rossi, F; Petrucci, MT; Guffanti, A; Marcheselli ...
Such as type 4 collagen Shaw, Andrey S.; Filbert, Erin L. (January 2009). "Scaffold proteins and immune-cell signalling". ... "Human Homologue of the Drosophila Discs Large Tumor Suppressor Binds to p56 lck Tyrosine Kinase and Shaker Type Kv1.3 Potassium ... 8 (5): 983-993. doi:10.1016/S1097-2765(01)00383-5. PMID 11741534. Huang, Guo N.; Huso, David L.; Bouyain, Samuel; Tu, Jianchen ... 8 (2): 154-161. doi:10.1038/ni1422. PMID 17187070. S2CID 11906543. Round, June L.; Tomassian, Tamar; Zhang, Min; Patel, Viresh ...
... chain of type VI collagen". J. Biol. Chem. 272 (36): 22817-23. doi:10.1074/jbc.272.36.22817. PMID 9278443. Suzuki Y, Yoshitomo- ... These two transcripts contain the same eight coding exons, and therefore, encode the same protein. GRCh38: Ensembl release 89: ... 437 (7062): 1173-8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026. Miyamoto A, Lau R, Hein ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Brown-Augsburger P, Broekelmann T, Rosenbloom J, Mecham RP ( ...
... of which is collagen type 1 and the remaining 10% ground substance, which includes dentin-specific proteins), and 8% water ( ... There are three types of dentin, primary, secondary and tertiary. Secondary dentin is a layer of dentin produced after the root ... It is of two types, either reactionary, where dentin is formed from a pre-existing odontoblast, or reparative, where newly ... It can and can be identified by the presence of various characteristics, including collagen fibres found perpendicular to the ...
... and Fibromyalgia all conducted with Type II hydrolyzed collagen (collagen hydrolysate), the primary ingredient in Calorad. The ... Calorad Classic is a liquid dietary supplement composed primarily of 3,000 mg (3 grams) of Type II hydrolyzed collagen ( ... "Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial ... Olson, G. B.; Savage, S.; Olson, J. (2000). "The effects of collagen hydrolysat on symptoms of chronic fibromyalgia and ...
... type IV, alpha 1 Collagen, type V, alpha 1 Collagen, type VI, alpha 1 Collagen, type VII, alpha 1 Collagen, type VIII, alpha 1 ... Collagen, type IX, alpha 1 Collagen, type X, alpha 1 Collagen, type XI, alpha 1 Collagen, type XII, alpha 1 Collagen, type XIII ... type XIV, alpha 1 Collagen, type XV, alpha 1 Collagen, type XVI, alpha 1 Collagen, type XVII, alpha 1 Collagen, type XVIII, ... A1 polypeptide collagen, type I, alpha 1 collagen, type II, alpha 1 Collagen, type III, alpha 1 Collagen, ...
... and steepen the cornea with a ring of collagen constriction. It can also be used to treat selected types of astigmatism. It is ... The newest type of intervention is a type of PIOL called the implantable collamer lens (ICL) which uses a biocompatible ... Meanwhile, experiments in 1970 using a xenon dimer and in 1975 using noble gas halides resulted in the invention of a type of ... It is a type of refractive surgery which reshapes the cornea by removing microscopic amounts of tissue from the corneal stroma ...
Third Fibronectin Type III Repeat). The L-type lectin domain is a variation of the jelly roll fold. The C2 domain in its ... The jelly-roll topology is found in carbohydrate binding proteins such as concanavalin A and various lectins, in the collagen ... The immunoglobulin-type fold found in antibodies (Ig-fold) consists of a sandwich arrangement of 7 and 9 antiparallel β-strands ... typical version (PKC-C2) is a β-sandwich composed of 8 β-strands. Kister, A. E.; Fokas, A. S.; Papatheodorou, T. S.; Gelfand, I ...
"C-propeptide region of human pro alpha 1 type 1 collagen interacts with thioredoxin". Biochemical and Biophysical Research ... Plants have an unusually complex complement of Trxs composed of six well-defined types (Trxs f, m, x, y, h, and o) that reside ... 274 (5): 3182-8. doi:10.1074/jbc.274.5.3182. PMID 9915858.. *^ Li X, Luo Y, Yu L, Lin Y, Luo D, Zhang H, He Y, Kim YO, Kim Y, ... 8 (3): 757-64. doi:10.1002/j.1460-2075.1989.tb03436.x. PMC 400872. PMID 2785919.. ...
This involved a mutation of the protein collagen, type X, alpha 1, encoded by the COL10A1 gene. In humans a similar mutation ( ... December 2000). "Abnormal growth plate function in pigs carrying a dominant mutation in type X collagen". Mamm. Genome. 11 (12 ... Savarirayan, Ravi (4 July 2019). "C-Type Natriuretic Peptide Analogue Therapy in Children with Achondroplasia". New England ... This protein contributes to the production of collagen and other structural components in tissues and bones. When the FGFR3 ...
Several types of catenins work with N-cadherins to play an important role in learning and memory (For full article, see ... Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR (October 2011). "A role for collagen XXIII in cancer cell ... For instance, higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened ... levels of collagen helped facilitate adhesions and anchorage-independent cell growth and provided evidence of collagen XXIII's ...
Atrophic acne scars have lost collagen from the healing response and are the most common type of acne scar (account for ... viii-ix. doi:10.1016/j.det.2011.09.001. PMID 22117871.. ... Ablative lasers (such as CO2 and fractional types) have also ... microspheres with collagen; human and bovine collagen derivatives, and fat harvested from the person's own body (autologous fat ... Many over-the-counter treatments in many forms are available, which are often known as cosmeceuticals.[168] Certain types of ...
List of human cell types derived from the germ layers. References[edit]. *^ .mw-parser-output cite.citation{font-style:inherit ... doi:10.1016/S0168-9525(03)00176-8. PMID 12902164.. *^ a b Tate, Melissa L Knothe; Thomas D. Falls; Sarah H McBride; Radhika ... COL2A1 collagen disease. *Achondrogenesis *type 2. *Hypochondrogenesis. SLC26A2 sulfation defect. *Achondrogenesis *type 1B ... 5 (8): e1000616. doi:10.1371/journal.pgen.1000616. PMC 2721633. PMID 19696890.. ...
... the rate of collagen loss will be accelerated and extreme pH can cause collagen swelling and accelerated hydrolysis.[8] Due to ... The study of diagenesis in rocks is used to understand the geologic history they have undergone and the nature and type of ... The composite nature of bone, comprising one-third organic (mainly protein collagen) and two thirds mineral (calcium phosphate ... The hydrolytic activity plays a key role in the mineral phase transformations that exposes the collagen to accelerated chemical ...
Type I collagen is present in many forms of connective tissue, and makes up about 25% of the total protein content of the ... Type I Collagen". Journal of Biological Chemistry. 277 (6): 4223-31. doi:10.1074/jbc.M110709200. PMID 11704682.. ... TypesEdit. Connective tissue can be broadly subdivided into connective tissue proper, and special connective tissue.[5][6] ... groups of adipose cells are kept together by collagen fibers and collagen sheets in order to keep fat tissue under compression ...
10% of all dislocations are anterior and this is broken down into superior and inferior types.[32] Superior dislocations ... syndrome is genetically inherited disorder that is thought to affect the encoding of the connective tissue protein's collagen ... the most common type of shoulder dislocation (96-98% of the time) occurs when the arm is in external rotation and abduction ( ... 83(8): 1119-1124. *^ Warby, Sarah A.; Pizzari, Tania; Ford, Jon J.; Hahne, Andrew J.; Watson, Lyn (2014-01-01). "The effect of ...
Both types of plants occur in tropical areas, but only C3 plants occur naturally in colder areas. 12C and 13C occur in a ratio ... Based on stable isotope levels, eight Cobern Street Burial Ground individuals consumed a diet based on C4 (tropical) plants in ... Nitrogen isotopes in bone collagen are ultimately derived from dietary protein, while carbon can be contributed by protein, ... This references the variety of types of labor (e.g., domestic vs. carrying heavy loads) labor that enslaved individuals were ...
Possibly important to basement membrane architecture and tissue development, as a needed catalyst to make collagen IV.[37] ... "Retrieved November 8, 2011.. *^ Corbridge, D. E. C. (1995-02-01). Phosphorus: An Outline of Its Chemistry, Biochemistry, and ... 527-8. ISBN 1-133-10405-3. Retrieved 10 July 2016.. *^ "Chromium". Office of Dietary Supplements, US National Institutes of ... ISBN 978-1-4665-0572-8. Retrieved 3 July 2016.. *^ Harris, Ph.D., Edward D. (1 January 2014). Minerals in Food Nutrition, ...
Data also proposed a decrease in weight gain as a result of increased consumption lessens the risk of developing diabetes type ... Foundation for strong healthy bones and teeth - majority of the calcium consumed as a child is deposited onto collagen bone ... In 2007, only 22% and 61% of four- to eight-year-old children were meeting these recommendations. School-based lunch times ... Vitamin A ensures sufficient collagen is produced to build strong healthy bones and other connecting tissues (Deen & Hark, 2007 ...
Based on this, eight types of secondary structure are assigned. The 310 helix, α helix and π helix have symbols G, H and I and ... is at least 70°), and a blank (or space) is used if no other rule applies, referring to loops.[3] These eight types are usually ... Two types of beta sheet structures exist; a beta bridge has symbol B while longer sets of hydrogen bonds and beta bulges have ...
Type. Appearance (micrograph). Appearance (illustration). Approx. %. in adults. See also:. Blood values. Diameter (μm)[7]. Main ... It rises in response to allergies, parasitic infections, collagen diseases, and disease of the spleen and central nervous ... This type of white blood cell decreased is usually the neutrophil. In this case the decrease may be called neutropenia or ... Types of white blood cells can be classified in standard ways. Two pairs of broadest categories classify them either by ...
There are two types of alveolar epithelial cells - Type 1 pneumocytes represent 90% of the cell surface area, and are easily ... Mice that survive this initial onslaught go on to demonstrate an increase in lung collagen content, and decreased lung ... Type 2 pneumocytes are more resistant to damage, which is important as these cells produce surfactant, transport ions and ... Depending on the type and amount of irritant gas inhaled, victims can experience symptoms ranging from minor respiratory ...
... of which is collagen type 1 and the remaining 10% ground substance, which includes dentine-specific proteins), and 10% water ( ... TypesEdit. There are three types of dentin, primary, secondary and tertiary.[13][14] Secondary dentin is a layer of dentin ... It is of two types, either reactionary, where dentin is formed from a pre-existing odontoblast, or reparative, where newly ... It is unmineralized and consists of collagen, glycoproteins and proteoglycans. It is similar to osteoid in bone and is thickest ...
Types[edit]. General[edit]. Irwin Fridovich and Joe McCord at Duke University discovered the enzymatic activity of superoxide ... insights into heparin and collagen binding". J. Mol. Biol. 388 (2): 310-26. doi:10.1016/j.jmb.2009.03.026. PMID 19289127.. ... Fe and Mn types (which bind either iron or manganese), and the Ni type (which binds nickel). ... In wild-type S. cerevisiae, DNA damage rates increased 3-fold with age, but more than 5-fold in mutants deleted for either the ...
collagen trimer. • proteinaceous extracellular matrix. • extracellular region. • extracellular exosome. • extracellular space. ... 278 (8): 6160-7. doi:10.1074/jbc.M208322200. PMID 12456677.. *. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). " ... 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.. *. Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). " ...
... organelles which are present in many cellular types throughout the human body. The cilia defects adversely affect "numerous ... Retrieved November 8, 2010.. *^ Ruiz-Perez VL, Ide SE, Strom TM, et al. (2000). "Mutations in a new gene in Ellis-van Creveld ... is a rare genetic disorder of the skeletal dysplasia type. ... COL2A1 collagen disease. *Achondrogenesis *type 2. * ... The disorder was described by Richard W. B. Ellis (1902-1966) of Edinburgh and Simon van Creveld (1895-1971) of Amsterdam.[8] ...
... as healthy collagen replaces the defective collagen with vitamin C repletion. Treatment can be orally or by intramuscular or ... Yamada H, Yamada K, Waki M, Umegaki K (October 2004). "Lymphocyte and plasma vitamin C levels in type 2 diabetic patients with ... six to eight months were required, possibly due to the pre-loading of this group with a 70 mg/day supplement for six weeks ... including wound healing and collagen synthesis. In humans, vitamin C deficiency leads to impaired collagen synthesis, ...
Work at the Institute for Cell Biology, University of Bonn, showed that a certain type of autophagy, i.e., chaperone-assisted ... Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... 38 (8): 1098-103. doi:10.1248/bpb.b15-00096. PMID 26235572.. *^ a b c Mizushima, Noboru; Yoshimori, Tamotsu; Ohsumi, Yoshinori ... CMA is significantly different from other types of autophagy because it translocates protein material in a one by one manner, ...
Two types of PDGFRs have been identified: alpha-type and beta-type PDGFRs.[8] The alpha type binds to PDGF-AA, PDGF-BB and PDGF ... The addition of PDGF at specific time‐points has been shown to stabilise vasculature in collagen‐glycosaminoglycan scaffolds.[ ... Types and classification[edit]. There are five different isoforms of PDGF that activate cellular response through two different ... The receptor for PDGF, PDGFR is classified as a receptor tyrosine kinase (RTK), a type of cell surface receptor. ...
The three main types of hyaluronidases are two classes of eukaryotic endoglycosidase hydrolases and a prokaryotic lyase-type of ... "Testicular hyaluronidase induces tubular structures of endothelial cells grown in three-dimensional collagen gel through a CD44 ... 8] a form of subcutaneous immunoglobulin (SCIG) that uses Hylenex to allow for a far greater volume of SCIG to be administered ... 74 (1): 40-8. doi:10.1128/IAI.74.1.40-48.2006. PMC 1346594. PMID 16368955.. ...
TNF can bind two receptors, TNFR1 (TNF receptor type 1; CD120a; p55/60) and TNFR2 (TNF receptor type 2; CD120b; p75/80). TNFR1 ... Tumor necrosis factor (TNF) alpha increases collagen accuulation and proliferation in intestinal myofibrobasts via TNF Receptor ... TNF is primarily produced as a 233-amino acid-long type II transmembrane protein arranged in stable homotrimers.[24][25] From ... TNF was thought to be produced primarily by macrophages,[36] but it is produced also by a broad variety of cell types including ...
Work at the Institute for Cell Biology, University of Bonn, showed that a certain type of autophagy, i.e., chaperone-assisted ... Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... There are three main types of autophagy (macroautophagy, microautophagy and Chaperone mediated autophagy), these are mediated ... 38 (8): 1098-103. doi:10.1248/bpb.b15-00096. PMID 26235572.. *^ a b c Mizushima N, Yoshimori T, Ohsumi Y (10 November 2011). " ...
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C- ... Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen".[citation needed] Collagen IV ... type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 ... Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase?". Alcoholism: ...
Saad, Mohamed (Oct 1994). Low resolution structure and packing investigations of collagen crystalline domains in tendon using ... Kraft and sulfite (also called sulphite) refer to the type of pulping process used to remove the lignin bonding the original ... Instances are collagen[3] family of proteins, tendon, muscle proteins like actin, cell proteins like microtubules and many ... ISBN 0-13-017440-8. *^ James Edward Gordon; Philip Ball (2006). The new science of strong materials, or, Why you don't fall ...
After CGPD resolves, the skin may return to normal without scarring or may have small atrophic depressions with collagen loss, ... Gianotti-type perioral dermatitis or Facial Afro-Caribbean childhood eruption Specialty. Dermatology. ... "Annals of Dermatology (Review). 23 (3): 386-8. doi:10.5021/ad.2011.23.3.386. PMC 3162274. PMID 21909215.. ... Tetracycline antibiotics are not recommended for children under the age of 8 since tetracyclines are known to deposit in teeth ...
Collagen cross-linking by applying riboflavin topically then shining UV light is a method to slow progression of corneal ... One such organism is Micrococcus luteus (American Type Culture Collection strain number ATCC 49442), which develops a yellow ... Retrieved 8 December 2016.. *^ a b Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones ... Retrieved 8 December 2016.. *^ Board, NIIR (2012). The Complete Technology Book on Dairy & Poultry Industries With Farming and ...
Platelet activation (through agonists such as thrombin, Type II collagen and ADP) results in "membrane flipping" where the ... The extracellular region of P-selectin is composed of three different domains like other selectin types; a C-type lectin-like ... a type of glycosaminoglycan (GAG). Its activity in tumor metastasis has been probed by the addition of heparin that functions ... 7 (8): 1277-84. doi:10.1093/hmg/7.8.1277. PMID 9668170.. *^ Pan J, Xia L, McEver RP (April 1998). "Comparison of promoters for ...
ANA type. Target antigen. Sensitivity (%) SLE. Drug-induced LE. Diffuse systemic sclerosis. Limited systemic scleroderma. ... collagen IV, fibronectin and laminin. Binding to these antigens within the kidney could cause inflammation and complement ... There are ten proteins in this complex and antibodies to eight of them are found at varying frequencies; PM/Scl-100 (70-80%), ... Some ANAs appear in several types of disease, resulting in lower specificity of the test. For example, IgM-rheumatoid factor ( ...
"Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen" ... 8] முகிழ்கருவின் நார்க்குருத்துக் கலங்களில் இருந்து தான் சில இணைப்பிழையங்கள் உருவாகின்றன. முதல்வகைப் பிசின்மம் பல வடிவ ...
July 2002). "D-Amino acid residue in the C-type natriuretic peptide from the venom of the mammal, Ornithorhynchus anatinus, the ... "Extraction and identification of collagen-derived peptides with hematopoietic activity from Colla Corii Asini". Journal of ... An octapeptide has eight amino acids (e.g., angiotensin II).. *A nonapeptide has nine amino acids (e.g., oxytocin). ... B-type Natriuretic Peptide (BNP) - produced in myocardium & useful in medical diagnosis ...
J:35224 Iruela-Arispe ML, et al., Expression of type VIII collagen during morphogenesis of the chicken and mouse heart. Dev ... Blue cells = expressed in wild-type.. Gray triangles = other expression annotations only. (e.g. absence of expression or data ...
VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to ... A collagen heterotrimer containing type VIII alpha chains; [alpha1( ... Collagen type VIII expression in human diabetic nephropathy. * Efficient Generation of Human Embryonic Stem Cell-Derived ... Maternal exposure to carbon black nanoparticle increases collagen type VIII expression in the kidney… ...
Collagen degradation (Homo sapiens) * Collagen type VIII degradation by ELANE (Homo sapiens) * Collagen type VIII fibril [ ... Collagen type VIII degradation by MMP1 (Homo sapiens) * Collagen type VIII fibril [extracellular region] (Homo sapiens) ... Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Homo sapiens) * Collagen type VIII fibril [extracellular ... Collagen types III, IV, V, VI, VIII, IX, XVI [extracellular region] (Homo sapiens) * Collagen type VIII fibril [extracellular ...
... has enzymatic activity against native type I collagen, and the activity was inhibited by EDTA, 1,10- … ... tMMP-8) lacking a portion of the carboxy terminus and with an intact aminoterminus (latent; l-tMMP-8) or a truncated amino ... Background/aims: Excess type I collagen accumulation is a major feature of fibrotic diseases such as liver cirrhosis. Reversion ... being the most active against type I collagen. Introduction of MMP-8 gene into liver cells could be an advantageous tool to ...
Aubrey Organics, Body Lotion, Collagen & Almond, All Skin Types, 8 fl oz (237 ml) 93 Reviews ... Aubrey Organics, Body Lotion, Collagen & Almond, All Skin Types, 8 fl oz (237 ml). By. Aubrey Organics. ... Aubrey Organics, Body Lotion, Collagen & Almond, All Skin Types, 8 fl oz (237 ml). By. Aubrey Organics. ... Aubrey Organics, Body Lotion, Collagen & Almond, All Skin Types, 8 fl oz (237 ml). By Aubrey Organics ...
VIII) chain of type VIII collagen, have previously been described in patients with both FECD and PPCD,4,5 and type … ... Exclusion of COL8A1, the gene encoding the α2(VIII) chain of type VIII collagen, as a candidate for Fuchs endothelial dystrophy ... Exclusion of COL8A1, the gene encoding the α2(VIII) chain of type VIII collagen, as a candidate for Fuchs endothelial dystrophy ...
Efficacy and Safety of Riboflavin-Ultraviolet Type A Rays Inducing Cross-Linking of Corneal Collagen in Patients Aged 8 to 16 ... Efficacy and Safety of Riboflavin-Ultraviolet Type A Rays Inducing Cross-Linking of Corneal Collagen in Patients Aged 8 to 16 ... Efficacy and Safety of Riboflavin-Ultraviolet Type A Rays Inducing Cross-Linking of Corneal Collagen in Patients Aged 8 to 16 ... Purpose : To assess the effectiveness and safety of riboflavin-ultraviolet type A (UVA) rays induced cross-linking (CXL) of ...
These studies indicate that the dye and light treatment of insoluble Type I collagen (1) results in cross-linking of collagen ... Insoluble Type I collagen from bovine Achilles tendon (Sigma C9879) was suspended in a 3 mM solution of the dye diEd66Br ... Gel electrophoretic studies of photochemical cross-linking of type I collagen with brominated 1,8-naphthalimide dyes and ... Following pelleting of the collagen by centrifugation and 3x washing in phosphate-buffered saline, aliquots of light-treated ...
Anti-type II collagen antibodies, anti-CCP, IgA RF and IgM RF are associated with joint damage, assessed eight years after ... Background: Early appearance of antibodies specific for native human type II collagen (anti-CII) characterizes an ... Keywords: Arthritis, Juvenile Idiopathic Arthritis, Anti-CCP, Rheumatoid factor, Anti-collagen type II antibodies, ... assessed after eight years of disease. The role of anti-CII in JIA should be further studied. ...
Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 Stable Identifier ... Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Bos taurus) ... Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Bos taurus) ... Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens) ...
... that did not react with the anti-type VIII collagen IgG. Type VIII collagen therefore appears to be synthesized as a ... that did not react with the anti-type VIII collagen IgG. Type VIII collagen therefore appears to be synthesized as a ... that did not react with the anti-type VIII collagen IgG. Type VIII collagen therefore appears to be synthesized as a ... that did not react with the anti-type VIII collagen IgG. Type VIII collagen therefore appears to be synthesized as a ...
The collagen fiber network was developed in a representative volume element, which used the inter-fiber spacing to regulate the ... In this work, the role of crosslinks in terms of density and stiffness on the macroscopic behavior of collagen gel were ... Results suggest that the cross-linked fiber alignment dominated the strain stiffening effect of the collagen gel. In addition, ... This work could enhance our understanding of collagen gel mechanics and shed lights on designing future clinical relevant ...
... as well as in association with tissues containing type I collagen. Autoimmunity against type V collagen is associated with lung ... Type V collagen is a form of fibrillar collagen associated with classical Ehlers-Danlos syndrome. It is found within the dermal ... "Type V collagen controls the initiation of collagen fibril assembly". J. Biol. Chem. 279 (51): 53331-7. doi:10.1074/jbc. ... Collagen+Type+V at the US National Library of Medicine Medical Subject Headings (MeSH) v t e. ...
Collagen Type VIII Alpha 2 Chain, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - ... COL8A2 (Collagen Type VIII Alpha 2 Chain) is a Protein Coding gene. Diseases associated with COL8A2 include Corneal Dystrophy, ... This gene encodes the alpha 2 chain of type VIII collagen. This protein is a major component of the basement membrane of the ... Missense mutations in COL8A2, the gene encoding the alpha2 chain of type VIII collagen, cause two forms of corneal endothelial ...
This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major ... collagen type VIII alpha 1 chain. Enable Javascript to view the expand/collapse boxes.. Open All Close All ... The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the ...
Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. Here the D is approximately 67 nm and ... These form the most abundant collagens in vertebrates. ... There are 29 genetically distinct collagens present in animal ... VIII. some endothelial cells. COL8A1, COL8A2. Posterior polymorphous corneal dystrophy 2. IX. FACIT collagen, cartilage, assoc ... Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen ...
colocalizes_with collagen-containing extracellular matrix ISS Inferred from Sequence or Structural Similarity. more info ... a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8. ... Gene type. protein coding. RefSeq status. REVIEWED. Organism. Homo sapiens Lineage. Eukaryota; Metazoa; Chordata; Craniata; ... TSP1; Thrombospondin type 1 repeats. cd04273. Location:219 → 426. ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like ...
The purified mass is dried to provide the desired Type I collagen product which may be ground into a powder or formed into a ... The enzyme-treated comminuted material which is rich in collagen is dispersed in an organic acid to cause the fibrillar mass to ... source such as poultry feet that incorporates a fibrillar mass of connective tissue as well as bony tissue to yield a collagen ... collagen matrix or sponge, depending on the end use therefor. ... A process for extracting type I collagen from an avian ...
Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II ... Type II collagen autoimmunity in animals and provocations leading to arthritis. Immunol Rev 1990; 118: 193-232.. Direct Link: ... Analysis of type I and IV collagens by FT-IR spectroscopy and imaging for a molecular investigation of skeletal muscle ... Antibodies to type II collagen in early rheumatoid arthritis: correlation with disease progression. Arthritis Rheum 1996; 39: ...
The extracellular matrix of the membranes contained collagen types I, III, IV, and V; fibronectin; laminin; mucopolysaccharide ... Primary antisera to c-retinaldehyde-binding protein; leukocyte common antigen; factor VIII-related antigen; S-100 protein; ... Publication type, MeSH terms, Substances. Publication type. *Research Support, Non-U.S. Govt ... collagen types I, II, III, IV, and V; laminin; and fibronectin were used for immunohistochemical characterization of the ...
... and type IV collagen (tissue framework; brown) showed that the number of OX62+BrdU+ cells increased significantly in the spleen ...
Distribution of type VIII collagen in tissues: an immunohistochemical study. Connect Tissue Res 1990; 24: 303-318.. *CrossRef, ... Type VIII collagen. Int J Biochem Cell Biol 1997; 29: 1145-1148.. *CrossRef, ... The interaction of decorin core protein fragments with type I collagen. Biochem Biophys Res Commun 1992; 189: 165-172.. * ... Long-term in vitro function of adult hepatocytes in a collagen sandwich configuration. Biotechnol Prog 1991; 7: 237-245.. ...
This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha ... Collagen, type VII, alpha 1 has been shown to interact with Laminin 5 and Fibronectin. Collagen GRCh38: Ensembl release 89: ... of type VII collagen is amino-terminal and chimeric. Homology to cartilage matrix protein, the type III domains of fibronectin ... "Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin". The ...
VIII) collagen. Learn about this gene and related health conditions. ... The COL8A2 gene provides instructions for making a component of type VIII collagen called alpha 2( ... VIII) collagen. Type VIII collagen is largely found within the front surface of the eye, called the cornea. Type VIII collagen ... To construct type VIII collagen, one subunit of the alpha 2(VIII) collagen protein interacts with two subunits of another ...
As expected, approximately half of the embryos in these litters (four of eight embryos and three of seven embryos) were P3H2−/− ... Collagens constitute nearly 30% of all proteins in our body (1). Among the 29 collagen types, type IV collagen is a major and ... collagen types I, II, and III) and networks (collagen types IV and VI) (1). Proper posttranslational modifications of collagen ... C and D) Presence of type IV collagen in both P3H2-null and control embryos at E6 (green) is shown. colIV, type IV collagen. (E ...
Anti-idiotypic antibodies against BP-IgG prevent type XVII collagen depletion. Front Immunol. 2017;8:1669.CrossRefPubMed ... Type I and type II Fc receptors regulate innate and adaptive immunity. Nat Immunol. 2014;15(8):707-16.CrossRefPubMedGoogle ... Immunoadsorption against two distinct epitopes on human type XVII collagen abolishes dermal-epidermal separation induced in ... Protection in antibody- and T cell-mediated autoimmune diseases by antiinflammatory IgG Fcs requires type II FcRs. Proc Natl ...
Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, ... and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen ...
Thus, antibodies to these domains should stain fibroblasts synthesizing type I collagen but not extracellular collagen fibrils ... Embryonic chick tendon fibroblasts actively synthesizing type I collagen stained heavily with Anti-pC, while quiescent adult ... Type I procollagen carboxyterminal domains are proteolytically removed during collagen secretion. ... A monoclonal antibody to the carboxyterminal domain of procollagen type I visualizes collagen-synthesizing fibroblasts. ...
The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance ... The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance ... This chapter outlines several methods to assess the in vitro production of type I collagen that are employed in our laboratory ... Type I collagen Western immunoblot real-time PCR nuclear run-on assay ...
... especially actomyosin and Type I collagen, which is found in muscle joints.[8] ... The specificity of zingibains binding ensures predominant hydrolyzation of actomyosin and Type I collagen. ... Zingibain exhibits complex-type N-linked oligosaccharide chains at two residues.[1] Chains are between 5-13 glycosyl units long ... Zingibain is also used to flavor sausages and baked products.[8] Rennet substitute[edit]. For over the past 100 years, ginger ...
  • Immunofluorescence studies with the mAb showed the type VIII collagen was deposited as fibrils in the extracellular matrix of corneal endothelial cells. (elsevier.com)
  • We conclude that this unusual collagen is a component of certain specialized extracellular matrices, several of which are derived from the neural crest. (elsevier.com)
  • Sage, E. H. / Type VIII collagen has a restricted distribution in specialized extracellular matrices . (elsevier.com)
  • Partially ligated ApoE knockout mice, a more physiologically relevant model of low and oscillatory flow, developed an advanced lesion in 2 weeks, and orally administered 8-OHdG significantly reduced plaque formation along with reduced superoxide formation, monocyte/macrophage infiltration, and extracellular matrix (ECM) accumulation. (nih.gov)
  • Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. (wikipedia.org)
  • The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. (rcsb.org)
  • Thus, antibodies to these domains should stain fibroblasts synthesizing type I collagen but not extracellular collagen fibrils which could mask the signal from the cells. (jci.org)
  • Laminins and collagens are molecules of the extracellular matrix which play particularly crucial roles in epithelial development. (stanford.edu)
  • To elucidate the role of extracellular matrix and basement membrane associated proteins at the ectodermal-ectomesenchymal interface of developing salivary glands, human fetal submandibular glands (n=100), gestational age varying from 10 to 40 weeks, were evaluated for expression of tenascin, type IV collagen and laminin by using immunohistochemical methods and the results were compared with their expression in adult glands (n=20). (nii.ac.jp)
  • They enable endothelial cells to attach to underlying extracellular matrix by binding to collagen and they interact with fibrin, heparin, and integrins. (ahajournals.org)
  • Collagen / ˈ k ɒ l ə dʒ ɪ n / is the main structural protein in the extracellular space in the various connective tissues in animal bodies. (wikipedia.org)
  • When tumors expand, the surrounding stroma undergoes constant remodeling and since collagen is the major component of the extracellular matrix, collagen synthesis and degradation is a key determinant for cancer invasion. (spandidos-publications.com)
  • The most thoroughly characterized pathway of collagen turnover is the proteolytic breakdown process occurring in the extracellular space. (spandidos-publications.com)
  • However, in addition to this well established extracellular breakdown pathway, a less characterized intracellular process in which collagen is internalized through binding to collagen-specific receptors on the cell surface and delivered for lysosomal degradation has also been identified. (spandidos-publications.com)
  • Collagen alpha-1(VIII) chain is a protein that in humans is encoded by the COL8A1 gene. (wikipedia.org)
  • Electrophoretic protein migration in 8% to 25% gradient polyacrylamide gels following SDS solubilization disclosed numerous, densely packed, essentially contiguous protein bands. (spie.org)
  • Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. (nih.gov)
  • This protein is a major component of the basement membrane of the corneal endothelium and forms homo- or heterotrimers with alpha 1 (VIII) type collagens. (genecards.org)
  • COL8A2 (Collagen Type VIII Alpha 2 Chain) is a Protein Coding gene. (genecards.org)
  • In the skin, the type VII collagen protein is synthesized by keratinocytes and dermal fibroblasts. (wikipedia.org)
  • To construct type VIII collagen, one subunit of the alpha 2(VIII) collagen protein interacts with two subunits of another protein called alpha 1(VIII) collagen. (medlineplus.gov)
  • The COL8A2 gene mutations that cause the early-onset variant of Fuchs endothelial dystrophy replace single protein building blocks in alpha 2(VIII) collagen. (medlineplus.gov)
  • These mutations impair the structure of alpha 2(VIII) collagen, probably preventing the abnormal protein from being incorporated into type VIII collagen fibers. (medlineplus.gov)
  • All identified mutations have occurred in two regions of the COMP protein, which are referred to as the type III and C-terminal domains. (medlineplus.gov)
  • Undernatured Type II Collagen is the principal structural protein in cartilage that is responsible for its tensile strength and toughness. (iherb.com)
  • p>This indicates the type of evidence that supports the existence of the protein. (uniprot.org)
  • The superficial zone consists of one to two layers of flattened chondrocytes expressing proteoglycan 4 or lubricin, SRY-box 9 (Sox9), type II collagen, aggrecan, tenascin C and low levels of cartilage intermediate layer protein. (bmj.com)
  • Expression of angiogenic factors vascular endothelial growth factor and interleukin-8/CXCL8 is highly responsive to ambient glutamine availability: role of nuclear factor-kappaB and activating protein-1. (semanticscholar.org)
  • We determined concentrations of PICP, ICTP, C-reactive protein (CRP), IL-6, IL-8, and tumor necrosis factor (TNF)-α by using enzyme-linked immunosorbent assay methods. (dovepress.com)
  • In 2000, two studies reported the cloning of uPARAP/Endo180, a type-1 membrane protein belonging to the mannose receptor family ( 9 , 10 ) which later turned out to be responsible for this process. (spandidos-publications.com)
  • Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. (news-medical.net)
  • Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen respectively. (news-medical.net)
  • Recessive dystrophic epidermolysis bullosa (RDEB) is an incurable disease caused by mutations in the gene encoding type VII collagen, the major component of anchoring fibrils (AF). (jci.org)
  • 12 13 Thus, the scenario was suggested that LDL bound to collagen, became oxidized, and would afterwards be taken up by macrophages gliding along collagen fibrils. (ahajournals.org)
  • Collagen consists of amino acids wound together to form triple- helices to form of elongated fibrils . (wikipedia.org)
  • The COL8A2 gene provides instructions for making a component of type VIII collagen called alpha 2(VIII) collagen. (medlineplus.gov)
  • Type VIII collagen molecules, expressed by corneal and vascular endothelial cells, are heterotrimers composed of 2 genetically distinct polypeptides, alpha-1(VIII) (COL8A1) and alpha-2(VIII) (COL8A2). (abcam.com)
  • This gene encodes the alpha 2 chain of type VIII collagen. (genecards.org)
  • Finally, a-tMMP-8 cDNA was cloned in a vector under transcriptional control of a regulated promoter (PEPCK-a-tMMP-8). (nih.gov)
  • IL-8 is represented in 53 dbEST cDNA libraries. (biomedcentral.com)
  • EST sequences in GenBank are derived from cDNA libraries generated from a vast array of tissue types including normal, disease-state, and variously treated tissues. (biomedcentral.com)
  • 8. The isolated nucleic acid of claim 7 , which is a cDNA. (google.com)
  • 9 10 11 The structure of two scavenger receptors, recently explored by cloning cDNA from bovine lung library and designated type I and type II, was found to contain a collagenous domain, which plays a key role in binding chemically modified proteins, such as acetylated LDL, ox-LDL, and maleylated bovine serum albumin. (ahajournals.org)
  • Determination of the complete cDNA sequence of rat type II collagen and evaluation of distinct expression patterns of types IIA and IIB procollagen mRNAs during fracture repair in rats. (biomedsearch.com)
  • First, we sequenced the rat collagen type II cDNA to design the primers. (biomedsearch.com)
  • Collagens constitute nearly 30% of all proteins in our body. (pnas.org)
  • Berg, R. A., Schwartz, M. L., and Crystal, R. G. (1980) Regulation of the production of secretory proteins: intracellular degradation of newly synthesized "defective" collagen. (springer.com)
  • They're made from proteins such as collagen, and minerals such as calcium. (healthline.com)
  • Made with collagen and elastin, proteins found in your skin, plus rich, moisturizing almond oil. (vitaglo.com)
  • The thrombospondins(TS) are a family of proteins which appear to be involved in the acute regulation of the migration, adhesion and proliferation of a number of cell types. (go.jp)
  • Vascular endothelial growth factor (VEGF) and interleukin-8/CXCL8 (IL-8) are prominent pro-angiogenic and pro-metastatic proteins that represent negative prognostic factors in many types of cancer. (semanticscholar.org)
  • Some serotypes, presence of multiple serotypes and strains with collagen ‐binding proteins (CBP, Cnm and Cbm) have been linked with systemic disease. (medworm.com)
  • An antibody was selected for biochemical and tissue immunofluorescence studies which reacted both with Descemet's membrane and with type VIII collagen 50,000-M(r) polypeptides by competition ELISA and immunoblotting. (elsevier.com)
  • This is the collagen of granulation tissue, and is produced quickly by young fibroblasts before the tougher type I collagen is synthesized. (news-medical.net)
  • 8-way Joint Formula is a balanced comprehensive joint supplement designed to support healthy connective tissue and joint structure, and maintain joint function and mobility. (jefferspet.com)
  • A process for extracting type I collagen from an avian source such as poultry feet that incorporates a fibrillar mass of connective tissue as well as bony tissue to yield a collagen product having useful medical and biotechnology applications. (google.co.uk)
  • The enzyme-treated comminuted material which is rich in collagen is dispersed in an organic acid to cause the fibrillar mass to undergo controlled swelling, after which the mass is separated from the bony tissue and purified to remove non-collangenous material. (google.co.uk)
  • Type VIII collagen is a major component of Descemet's membrane, which is a tissue at the back of the cornea. (medlineplus.gov)
  • The absence of staining in normal lung supports the hypothesis that fibrosis is associated with an altered collagen-synthesizing phenotype of tissue fibroblasts. (jci.org)
  • The use of hydrolyzed collagen in wound healing provides a lot of advantages in terms of stimulating tissue growth, and guarantees relief for different types of injuries. (transparencymarketresearch.com)
  • Binding of LDL to connective tissue of the arterial intima, such as various types of collagen, elastin, and glycosaminoglycans, was found to play an important role in the formation of atherosclerotic lesions. (ahajournals.org)
  • In particular, sarcopenia shows a muscle fiber distribution with a predominance of type I fibers correlated to an atrophy of type II fibers ( 5 ), and an accumulation of adipose tissue both around and between muscle fibers ( 6 ). (frontiersin.org)
  • Collagen constitutes one to two percent of muscle tissue and accounts for 6% of the weight of strong, tendinous muscles. (wikipedia.org)
  • Pathology of the collagen underpinning of the heart is understood within the category of connective tissue disease . (wikipedia.org)
  • However, collagen turnover is not only central for tumor invasion but is also a normal process in the healthy organism, occurring continuously at sites with tissue remodeling. (spandidos-publications.com)
  • In the fetal calf, type VII collagen was absent from basement membranes and was found in a limited number of tissues. (elsevier.com)
  • There are 29 genetically distinct collagens present in animal tissues. (news-medical.net)
  • Type I collagen is found throughout the body except in cartilaginous tissues. (news-medical.net)
  • Type II collagen is specific for cartilaginous tissues. (rcsb.org)
  • However, at present there is no simple method for assessing the collagen-synthesizing and secreting activity of fibroblasts in human tissues. (jci.org)
  • The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance between synthesis and degradation. (springer.com)
  • Additional analysis suggests that most IL-8 related genes are differentially expressed between non-tumor and tumor tissues. (biomedcentral.com)
  • To focus on IL-8's function in tumor tissues, we further analyzed and ranked the genes in 16 IL-8 related tumor libraries. (biomedcentral.com)
  • IL-8 is also found to be constitutively expressed in several tumor tissues including bronchogenic carcinoma, non-small cell lung cancer, colorectal carcinoma, breast cancer, melanoma, prostate cancer, gastric carcinoma, and ovarian cancer. (biomedcentral.com)
  • Coordinated expression of these and other factors with IL-8 in certain tumor tissues suggests that they may be functionally associated with IL-8 in these tumors. (biomedcentral.com)
  • Depending upon the degree of mineralization, collagen tissues may be either rigid (bone) or compliant (tendon) or have a gradient from rigid to compliant (cartilage). (wikipedia.org)
  • Using these models, we show here that ectopic expression of EGFR (both WT and vIII) in adult CNS tissues, in the context of p16Ink4a/p19ARF and PTEN inactivation, leads to the formation of GBMs de novo. (pnas.org)
  • The gene product is a short chain collagen and a major component of the basement membrane of the corneal endothelium. (wikipedia.org)
  • Collagen VIII is a member of the 'short chain collagen' subfamily, and is a major component of the hexagonal lattice in the Descemet membrane. (abcam.com)
  • Reviva's Elastin & Collagen Body Firming Lotion improves the appearance of slackened skin during weight loss and may help diminish the appearance of stretch marks. (pennherb.com)
  • Includes powdered Elastin Concentrate and premium Soluble Collagen to soothe skin. (pennherb.com)
  • These studies indicate that the dye and light treatment of insoluble Type I collagen (1) results in cross-linking of collagen molecules and (2) does not denature the trimer conformation sufficiently to enable significant digestion by pepsin. (spie.org)
  • These defects often cause problems in the biosynthesis of the collagen molecules, their assembly and posttranslational modification process that makes them their final end form of collagen. (news-medical.net)
  • Once these molecules are processed, they arrange themselves into long, thin bundles of mature type VIII collagen. (medlineplus.gov)
  • We have generated transgenic (tg) mice expressing HLA-DQ8αβ (DQA1*0301/DQB*0302) or HLA-DQ6αβ (DQA1*0103/DQB1*0601) molecules lacking endogenous murine class II expression (Aβ0) to investigate the ability of these HLA class II to present type II Collagen (CII) and induce collagen-induced arthritis. (elsevier.com)
  • To examine the interaction of DQ6αβ and DQ8αβ molecules in vivo, we generated double tg DQ6αβ/8αβ (Aβ0) mice expressing both the α- and β-chains of DQ6 and DQ8 molecules by mating DQαβ (Aβ0) and DQ8αβ (Aβ0) tg mice. (elsevier.com)
  • The DQ6αβ/8αβ tg mice provide a model to investigate putative autoantigens and the mechanisms of pathogenesis involved in relapsing polychondritis as well as the influence of the expression of multiple HLA class II molecules on the disease process. (elsevier.com)
  • A pepsin-resistant triple helical domain (chain 50,000 M(r)) of type VIII collagen was isolated from bovine corneal Descemet's membrane and used as an immunogen for the production of mAbs. (elsevier.com)
  • The mAb specifically precipitated a high molecular mass component of type VIII collagen (EC2, of chain 125,000 M(r)) from the culture medium of subconfluent bovine corneal endothelial cels metabolically labeled for 24 h. (elsevier.com)
  • Defects in this gene are associated with Fuchs endothelial corneal dystrophy and posterior polymorphous corneal dystrophy type 2. (genecards.org)
  • Amnion, the collagen-rich layer that forms the load-bearing structure of the fetal membrane, has regenerative capacity and has been used clinically to aid in the healing of various wounds including burns, diabetic ulcers, and corneal injuries. (frontiersin.org)
  • Journal of Biomedical Semantics 2017, 8 (1), 54. (ncl.ac.uk)
  • European Journal of Applied Physiology 2017, 117 (8), 1727-1737. (ncl.ac.uk)
  • Frontiers in Immunology 2017, 8 , 1866. (ncl.ac.uk)
  • ATHLONE, Ireland, March 29, 2017 (GLOBE NEWSWIRE) -- Innocoll Holdings plc (NASDAQ:INNL) ("Innocoll" or the "Company"), a global, commercial-stage, specialty pharmaceutical and medical device company, today announced receipt of formal Type A Meeting minutes from the United States Food and Drug Administration (FDA) relating to its New Drug Application (NDA) for XARACOLL (bupivacaine HCl collagen-matrix implant). (globenewswire.com)
  • Platelets express certain receptors, some of which are used for the adhesion of platelets to collagen. (wikipedia.org)
  • In the present study we examined platelet adhesion to purified vWF from flowing blood and compared its characteristics with those of the adhesion of platelets to collagen type III preincubated with vWF. (ahajournals.org)
  • The type VIII collagen fibril can be either a homo- or a heterotrimer. (wikipedia.org)
  • Type III collagen is found in the walls of arteries and other hollow organs and usually occurs in the same fibril with type I collagen. (news-medical.net)
  • The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. (wikipedia.org)
  • We cloned latent and active MMP-8 genes in prokaryotic and eukaryotic expression vectors and an adenoviral vector. (nih.gov)
  • Vuorio, E. and de Crombrugghe, B. (1990) The family of collagen genes. (springer.com)
  • We report a novel computational approach to identify co-expressed genes using EST database, and its application to IL-8. (biomedcentral.com)
  • This method generated a reference database for genes co-expressed with IL-8 and could facilitate further characterization of functional association among genes. (biomedcentral.com)
  • Hydrolyzed collagen or collagen hydrolysates are manufactured by the breaking of complex collagen peptides into a desired length of collagen peptide with the help of controlled enzymatic hydrolysis. (transparencymarketresearch.com)
  • At the Food Ingredient South America (FISA), Rousselot, a global leader of gelatin and collagen peptides, showcased its new line of hydrolyzed collagen ingredient portfolio. (transparencymarketresearch.com)
  • I'm not new to collagen peptides. (amzn.com)
  • I've been using them for a couple months now with surprising results and I'm a firm believer that collagen peptides have helped my skin look and feel tighter as well as more hydrated. (amzn.com)
  • We describe Western immunoblotting of intact α1(I) collagen using antibodies directed to α1(I) collagen amino and carboxyl propeptides. (springer.com)
  • Type VII collagen appears to play a key role in tumor invasion, and appears to operate through association with laminin-5. (stanford.edu)
  • The molecule collagen XVII is closely associated with laminin-5 and a6b4 integrin and also is required for tumor invasion. (stanford.edu)
  • Consistent with this, we show here that concomitant activation of wild-type and/or mutant (vIII) EGFR and ablation of Ink4A/Arf and PTEN tumor suppressor gene function in the adult mouse central nervous system generates a fully penetrant, rapid-onset high-grade malignant glioma phenotype with prominent pathological and molecular resemblance to GBM in humans. (pnas.org)
  • Studies of the activation of signaling events in these GBM tumor cells revealed notable differences between wild-type and vIII EGFR-expressing cells. (pnas.org)
  • The latest market estimate report published by Transparency Market Research on the global hydrolyzed collagen market includes a global industry analysis and opportunity assessment of the hydrolyzed collagen market for forecast period of 2019-2029 . (transparencymarketresearch.com)
  • Revenue generated from the global hydrolyzed collagen market has been estimated to be valued at ~US$ 870 Mn in 2019 , which is projected to increase at a CAGR of ~8% during the forecast period. (transparencymarketresearch.com)
  • reticulate (main component of reticular fibers ), commonly found alongside type I. (wikipedia.org)
  • The distinctive triple-helix structure and the ability to form large insoluble fibers makes collagen resistant to most proteases ( 5 ). (spandidos-publications.com)
  • The degradation process is initiated by the unwinding of collagen fibers which exposes cleavage sites targeted by these specialized proteases. (spandidos-publications.com)
  • This thickens the skin and stimulates deep collagen growth, resulting in a firmer feeling and more voluptuous buttocks. (hauteliving.com)
  • transmembrane collagen, interacts with integrin a1b1, fibronectin and components of basement membranes like nidogen and perlecan. (news-medical.net)
  • Collagen, type VII, alpha 1 has been shown to interact with Laminin 5 and Fibronectin. (wikipedia.org)
  • We investigated the binding of oxidized LDL (ox-LDL) to microtiter plates coated with type I or II collagen, laminin, fibronectin, or poly- d -lysine. (ahajournals.org)
  • Application of the F(ab′) 2 from a monoclonal antibody to ox-LDL revealed a strong competition of the binding of highly ox-LDL to type II collagen (60%), laminin (35%), type I collagen (20%), and poly- d -lysine (15%), whereas the binding to fibronectin was not affected. (ahajournals.org)
  • In addition to these collagen phenotypes and poly- d -lysine, we investigated for the first time the binding of ox-LDL to laminin and fibronectin. (ahajournals.org)
  • The measurement of α1(I) collagen mRNA levels using real-time polymerase chain reaction is then outlined. (springer.com)
  • and (3) type IIB collagen is the predominant mRNA variant expressed at virtually all times during fracture repair. (biomedsearch.com)
  • Fitzgerald, J., Lamande, S. R., and Bateman, J. F. (1999) Proteasomal degradation of unassembled mutant type I collagen pro-alpha1(I) chains. (springer.com)
  • Type IV collagen and laminin were observed in the basement membrane of salivary ducts and acini beginning from 16-18 weeks, and the intensity of reaction was more prominent during intermediate developing stages (19-32 weeks). (nii.ac.jp)
  • The present study suggests that tenascin forms an epithelial-ectomesenchymal interface before the organization of collagen IV and laminin in the basement membrane of salivary ducts and acini in developing human submandibular glands. (nii.ac.jp)
  • The best model included LAMC2 , encoding laminin-γ2 chain, and COL4A1 , encoding collagen, type IV α1 chain. (aacrjournals.org)
  • We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. (rsc.org)
  • Usage information: A monoclonal antibody to the carboxyterminal domain of procollagen type I visualizes collagen-synthesizing fibroblasts. (jci.org)
  • Embryonic chick tendon fibroblasts actively synthesizing type I collagen stained heavily with Anti-pC, while quiescent adult tendon fibroblasts did not stain with Anti-pC. (jci.org)
  • Thus, Anti-pC specifically visualized fibroblasts actively synthesizing collagen. (jci.org)
  • Bienkowski, R. S. (1984) Collagen degradation in human lung fibroblasts: extent of degradation, role of lysosomal proteases, and evaluation of an alternate hypothesis. (springer.com)
  • Introduction of MMP-8 gene into liver cells could be an advantageous tool to potentiate fibrosis degradation. (nih.gov)
  • The expression of procollagen 1 C-terminal peptide (PICP) and collagen type 1 C-terminal telopeptide (ICTP), two major by-products in the synthesis and degradation of collagen, was shown to be positively correlated with inflammatory mediator levels in previous studies. (dovepress.com)
  • Through the endocytosis of collagen or large collagen fragments, this recycling receptor serves to direct basement membrane collagen as well as interstitial collagen to lysosomal degradation. (spandidos-publications.com)
  • Type IV collagen is a major and crucial component of basement membranes. (pnas.org)
  • 8. The polypeptide fragment of claim 1 wherein the substrate is agarose. (google.es)
  • 9. The polypeptide fragment of claim 1 coupled to collagen. (google.es)
  • Epidermolysis bullosa acquisita involves an autoimmune reaction to this form of collagen. (wikipedia.org)
  • Will look forward to seeing even more benefits for these collagen capsules. (amzn.com)
  • Excess type I collagen accumulation is a major feature of fibrotic diseases such as liver cirrhosis. (nih.gov)
  • The accumulation of aggrecan and type II collagen around the cells, in alginate as well as in fibrin gel, gradually increased over the culture period. (bmj.com)
  • Accumulation of T cells reactive to type II collagen in synovial fluid of patients with rheumatoid arthritis. (semanticscholar.org)
  • Both human and bovine collagen is widely used as dermal fillers for treatment of wrinkles and skin aging. (wikipedia.org)
  • This gene encodes one of the two alpha chains of type VIII collagen. (wikipedia.org)
  • Zingibain exhibits complex-type N-linked oligosaccharide chains at two residues. (wikipedia.org)
  • Collagen chains undergo several posttranslational modifications that are indispensable for proper collagen function. (pnas.org)
  • Collagen-related diseases most commonly arise from genetic defects or nutritional deficiencies that affect the biosynthesis, assembly, postranslational modification, secretion, or other processes involved in normal collagen production. (news-medical.net)
  • Physiologically, collagen is degraded by interstitial collagenases, neutrophil collagenase (MMP-8) being the most active against type I collagen. (nih.gov)
  • When studying the influence of Na + , K + , Ca 2+ , Mg 2+ (equivalent to their concentrations in the interstitial fluid), native LDL, moderately ox-LDL, and highly ox-LDL showed the same affinity to type I collagen. (ahajournals.org)
  • The large non-collagenous domain (NC-1) of type VII collagen is amino-terminal and chimeric. (wikipedia.org)
  • Studies with SpIII, an amino-terminal dimeric proteolytic fragment of vWF, show that this fragment can also support adhesion to collagen. (ahajournals.org)
  • Testing certain amino acids as competitors for binding of highly ox-LDL to type I collagen put lysine first, followed by arginine and histidine. (ahajournals.org)
  • 8-Hydroxy-2-deoxyguanosine prevents plaque formation and inhibits vascular smooth muscle cell activation through Rac1 inactivation. (nih.gov)
  • Collagen-vascular diseases (CVDs) are a heterogeneous group of autoimmune disorders characterized by the presence of autoantibodies. (medscape.com)
  • One day Dr. Moore read about some studies on chicken collagen which showed that a small amount taken orally could have a preventive effect on rheumatoid arthritis. (prohealth.com)
  • What Dr. Moore discovered was that, unlike grandma's chicken soup, if he cooked the chicken collagen, it became ineffective. (prohealth.com)
  • not processed by high heat or chemicals) chicken collagen using the chicken's sternum cartilage. (prohealth.com)
  • Prolyl 3-hydroxylation is a crucial posttranslational modification of collagens. (pnas.org)
  • In addition there is excess collagen formation and deposition in scleroderma. (news-medical.net)
  • In addition to the above mentioned disorders, excessive deposition of collagen occurs in scleroderma. (news-medical.net)
  • Excessive collagen deposition plays a critical role in the development of fibrosis, and early or active fibrosis may be more susceptible to therapeutic intervention than later stages of scarring. (jci.org)
  • Gradual calcium deposition within collagen occurs as a natural function of aging. (wikipedia.org)
  • In conclusion, our results show a novel action of orally active 8-OHdG in suppressing atherosclerotic plaque formation in vivo and VSMC activation in vitro through inhibition of Rac1, which emphasizes a new therapeutic avenue to benefit atherosclerosis. (nih.gov)
  • This chapter outlines several methods to assess the in vitro production of type I collagen that are employed in our laboratory. (springer.com)
  • 8 On the other hand, ox-LDL was shown in vitro to bind to collagen gels. (ahajournals.org)
  • Finally, human chondrocytes in 1.0% alginate beads were embedded in 0.5% fibrin gel for eight weeks. (bmj.com)
  • CONCLUSION Human chondrocytes proliferate in this culture system, show an outgrowth into the surrounding fibrin, and synthesise a cartilage-like matrix for up to eight weeks. (bmj.com)
  • Implantation of autologous 5 or heterologous 4 6 chondrocytes, periosteum, 7 and perichondrium 8 9 has been used to fill chondral defects with a sufficient number of cells required to repair the cartilage. (bmj.com)
  • Implantation of isolated chondrocytes encapsulated in different artificial scaffolds such as synthetic polymers (carbon fibre, 10 polylactic acid, and polyglycolic acid 11 12 ) or biological matrices (demineralised bone matrix, 13 collagen, 4 14 15 hyaluronan, 16 17 fibrin 6 18 ) for chondral and osteochondral lesions has been reported. (bmj.com)
  • The chondrocytes of the radial and calcified zones express markers of chondrocyte differentiation and hypertrophy, such as type X collagen and alkaline phosphatase. (bmj.com)
  • Cartilage formation, and therefore the expression of type II collagen by chondrocytes, is a critical step in frac-ture healing. (biomedsearch.com)
  • Moreover, epigenetic silencing of P3H2 in breast cancers implies that the interaction between GPVI and non-3-hydroxylated type IV collagen might also play a role in the progression of malignant tumors and metastasis. (pnas.org)
  • Hypoxia is thought to be the primary environmental cause of VEGF and IL-8 expression in solid tumors. (semanticscholar.org)
  • We show that wild-type EGF receptor signals through its canonical pathways, whereas tumors arising from expression of mutant EGFR vIII do not use these same pathways. (pnas.org)
  • Derived from chicken sternum cartilage, UC-II is a patented form of Undernatured (native) Type II Collagen that works with the immune system to support healthy joints. (iherb.com)
  • Homotrimers, or heterotrimers in association with alpha 2(VIII) type collagens. (genecards.org)
  • Type I procollagen carboxyterminal domains are proteolytically removed during collagen secretion. (jci.org)
  • We developed and characterized a monoclonal antibody (Anti-pC) specific for the carboxyterminal propeptide of type I procollagen. (jci.org)
  • Two forms of type II collagen, IIA and IIB, are known to be produced by alternative splicing of the Alpha(1) (II) procollagen gene. (biomedsearch.com)
  • At the Vitafoods Europe 2018, Bioiberica presented two food supplements for joint and tendon health, out of which, one ingredient of the formula b-2cool® is hydrolyzed collagen. (transparencymarketresearch.com)
  • Frontiers in Immunology 2018, 8 , 1844. (ncl.ac.uk)
  • Type I collagen appeared after six weeks in alginate and in the surrounding fibrin. (bmj.com)
  • In experimental models attempts have been made to fill chondral lesions with biocompatible matrices, such as fibrin or collagen. (bmj.com)
  • 7 8 The essential contribution of vWF to adhesion to collagen and to fibrin(ogen) in flowing blood has also been established. (ahajournals.org)
  • ADAMTS-8 exhibits aggrecanase activity and is expressed in human articular cartilage. (nih.gov)
  • This is the most abundant collagen of the human body. (news-medical.net)
  • Newly created type VII collagen varied from 20% to 165% of that expressed in normal human skin and persisted for 3 months. (jci.org)
  • Human collagen type III from placental origin was obtained from Sigma Chemical Co. Unfractionated heparin (Thromboliquine) was purchased from Organon and LMWH (Fragmin) from Kabi Pharmacia. (ahajournals.org)
  • Angiogenic effects of interleukin 8 (CXCL8) in human intestinal microvascular endothelial cells are mediated by CXCR2. (semanticscholar.org)
  • Thus, in individual human GBMs, expression of EGFR WT , EGFR WT/vIII , or EGFR vIII is observed ( 4 - , 6 ). (pnas.org)
  • To understand EGFR signaling in GBM to better predict efficacy of targeted therapeutics, we developed 3 preclinical models of GBM based on overexpression of EGFR WT alone, coexpression of EGFR WT and vIII, and expression of EGFRvIII alone, thus reflecting natural occurrences in human GBMs. (pnas.org)
  • The presence of the human CAI gene in all hybrids correlates with the presence of chromosome 8. (deepdyve.com)
  • diagnosis, and to relate the occurrence of autoantibodies to outcome after eight years of disease in children with juvenile idiopathic arthritis (JIA). (bibsys.no)
  • Type VII collagen induction did not generate anti-type VII collagen autoantibodies in patients' blood or skin. (jci.org)
  • It is a heterogeneous disease that is caused by autoantibodies to the dermoepidermal junction, mainly type VII collagen. (biomedsearch.com)
  • NSCLC includes various types such as adenocarcinoma, squamous cell carcinoma, and large cell carcinoma [ 2 ]. (portlandpress.com)
  • Due to the diverse location of the collagen types they are associated with diseases. (news-medical.net)
  • The collagen linked diseases commonly arise from genetic defects or nutritional deficiencies. (news-medical.net)
  • With a particular focus on matrix turnover in cancer, this review presents the necessary background for understanding the function of uPARAP/Endo180 at the molecular and cellular level, followed by an in-depth survey of the available knowledge of the expression and role of this receptor in various types of cancer and other degenerative diseases. (spandidos-publications.com)
  • In this review, we summarize the features and function of uPARAP/Endo180 and discuss the putative role of this collagen receptor in various cancers and other diseases characterized by dysregulation of collagen remodeling. (spandidos-publications.com)
  • The susceptibility of DQ6αβ/8αβ tg mice compared with resistance in the parental strains suggests that expression of both the DQ6αβ and DQ8αβ tgs, unique to the DQ6αβ8αβ tg strain, is important in susceptibility to experimental polychondritis. (elsevier.com)