A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.
A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.
A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE.
In GRAM NEGATIVE BACTERIA, multiprotein complexes that function to translocate pathogen protein effector molecules across the bacterial cell envelope, often directly into the host. These effectors are involved in producing surface structures for adhesion, bacterial motility, manipulation of host functions, modulation of host defense responses, and other functions involved in facilitating survival of the pathogen. Several of the systems have homologous components functioning similarly in GRAM POSITIVE BACTERIA.
Mucopolysaccharidosis with excessive CHONDROITIN SULFATE B in urine, characterized by dwarfism and deafness. It is caused by a deficiency of N-ACETYLGALACTOSAMINE-4-SULFATASE (arylsulfatase B).
A fibrillar collagen found primarily in interstitial CARTILAGE. Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI.
An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.
Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A hepatic GLYCOGEN STORAGE DISEASE in which there is an apparent deficiency of hepatic phosphorylase (GLYCOGEN PHOSPHORYLASE, LIVER FORM) activity.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
A non-fibrillar collagen found in BASEMENT MEMBRANE. The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage.
A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.
Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A non-fibrillar collagen found primarily in terminally differentiated hypertrophic CHONDROCYTES. It is a homotrimer of three identical alpha1(X) subunits.
A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.
A fibril-associated collagen found in many tissues bearing high tensile stress, such as TENDONS and LIGAMENTS. It is comprised of a trimer of three identical alpha1(XII) chains.
A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
A type of extracellular vesicle, containing RNA and proteins, that is secreted into the extracellular space by EXOCYTOSIS when MULTIVESICULAR BODIES fuse with the PLASMA MEMBRANE.
Extracellular vesicles generated by the shedding of CELL MEMBRANE blebs.
The excitable plasma membrane of a muscle cell. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)
Interstitial space between cells, occupied by INTERSTITIAL FLUID as well as amorphous and fibrous substances. For organisms with a CELL WALL, the extracellular space includes everything outside of the CELL MEMBRANE including the PERIPLASM and the cell wall.
The functions and properties of living organisms, including both the physical and chemical factors and processes, supporting life in single- or multi-cell organisms from their origin through the progression of life.
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.
The functions and activities of living organisms that support life in single- or multi-cellular organisms from their origin through the progression of life.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.
An X-linked recessive muscle disease caused by an inability to synthesize DYSTROPHIN, which is involved with maintaining the integrity of the sarcolemma. Muscle fibers undergo a process that features degeneration and regeneration. Clinical manifestations include proximal weakness in the first few years of life, pseudohypertrophy, cardiomyopathy (see MYOCARDIAL DISEASES), and an increased incidence of impaired mentation. Becker muscular dystrophy is a closely related condition featuring a later onset of disease (usually adolescence) and a slowly progressive course. (Adams et al., Principles of Neurology, 6th ed, p1415)
A mammalian pancreatic extract composed of enzymes with protease, amylase and lipase activities. It is used as a digestant in pancreatic malfunction.
Time period from 1601 through 1700 of the common era.
Tumors or cancer of the LUNG.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.

Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M. (1/145)

The binding of certain growth factors and cytokines to components of the extracellular matrix can regulate their local availability and modulate their biological activities. We show that oncostatin M (OSM), a profibrogenic cytokine and modulator of cancer cell proliferation, specifically binds to collagen types I, III, IV, and VI, immobilized on polystyrene or nitrocellulose. Single collagen chains inhibit these interactions in a dose-dependent manner. Cross-inhibition experiments of collagen-derived peptides point to a limited set of OSM-binding collagenous consensus sequences. Furthermore, this interaction is found for OSM but not for other interleukin-6 type cytokines. OSM binding to collagens is saturable, with dissociation constants around 10(-8) m and estimated molar ratios of 1-3 molecules of OSM bound to one molecule of triple helical collagen. Furthermore, collagen-bound OSM is biologically active and able to inhibit proliferation of A375 melanoma cells. We conclude that abundant interstitial collagens dictate the spatial pattern of bioavailable OSM. This interaction could be exploited for devising collagenous peptide-antagonists that modulate OSM bioactivity in tumor growth and fibrotic disorders like rheumatoid arthritis and hepatic fibrosis.  (+info)

Flexibility and packing in proteins. (2/145)

Structural flexibility is an essential attribute, without which few proteins could carry out their biological functions. Much information about protein flexibility has come from x-ray crystallography, in the form of atomic mean-square displacements (AMSDs) or B factors. Profiles showing the AMSD variation along the polypeptide chain are usually interpreted in dynamical terms but are ultimately governed by the local features of a highly complex energy landscape. Here, we bypass this complexity by showing that the AMSD profile is essentially determined by spatial variations in local packing density. On the basis of elementary statistical mechanics and generic features of atomic distributions in proteins, we predict a direct inverse proportionality between the AMSD and the contact density, i.e., the number of noncovalent neighbor atoms within a local region of approximately 1.5 nm(3) volume. Testing this local density model against a set of high-quality crystal structures of 38 nonhomologous proteins, we find that it accurately and consistently reproduces the prominent peaks in the AMSD profile and even captures minor features, such as the periodic AMSD variation within alpha helices. The predicted rigidifying effect of crystal contacts also agrees with experimental data. With regard to accuracy and computational efficiency, the model is clearly superior to its predecessors. The quantitative link between flexibility and packing density found here implies that AMSDs provide little independent information beyond that contained in the mean atomic coordinates.  (+info)

Differential gene expression in human abdominal aorta: aneurysmal versus occlusive disease. (3/145)

OBJECTIVE: Inflammation and atherosclerosis are present in both abdominal aortic aneurysm (AAA) and arterial occlusive disease (AOD). Changes in gene expression that underlie the development of AAA versus AOD are poorly defined. This study evaluated differences in gene expression in AAA, AOD, and control aortic tissue with human gene array technology. METHODS: RNA was isolated from human aortic specimens (seven AAA, five AOD, and five control), and complementary DNA (cDNA) probes were generated. The cDNA probes were hybridized to a human cell interaction array of 265 genes and quantitated with phosphorimaging. The data were corrected for background and were standardized to housekeeping genes. Statistical differences in individual gene expression were determined with the Kruskal-Wallis test. RESULTS: Of 265 genes studied, 11 showed statistically different expression in diseased aorta as compared with control. The following three genes were downregulated in AAA: collagen VI alpha1 (P <.037), glycoprotein IIIA (P <.006), and alpha2-macroglobulin (P <.020). The following two genes were upregulated in AOD: laminin alpha4 (P <.034) and insulin-like growth factor 2 receptor (P <.049). The following three genes were upregulated in both AAA and AOD: matrix metalloproteinase-9 (MMP-9; P <.005), intercellular adhesion molecule-1 (P <.012), and tumor necrosis factor--beta receptor (P <.022). The following three genes were downregulated in both AAA and AOD: integrin alpha5 (P <.012), ephrin A5 (P <.037), and rho/rac guanine nucleotide exchange factor (P <.028). Of 16 MMPs evaluated, only MMP-9 was significantly (P <.005) upregulated in both AAA and AOD. Evaluation results of four tissue inhibitors of metalloproteinases showed no significant difference in expression for all tissue types, although tissue inhibitor of metalloproteinase-1 trended toward upregulation in AAA (P =.053). Eight of the fifteen most highly expressed genes in all the groups were extracellular matrix or secreted proteins. Of these, only collagen VI alpha1 (P <.037) showed a significant change, although biglycan trended toward downregulation in AAA (P =.076). CONCLUSION: This study used cDNA array technology in the comparison of human control and pathologic aortic tissue. Six genes had similar differential expression in both AAA and AOD as compared with control. Even more interesting were differences between AAA and AOD in the expression of five genes. These data suggest a similarity in genetic expression for both AAA and AOD, with altered expression of several genes playing a role in disease differentiation.  (+info)

Antibody response against perlecan and collagen types IV and VI in chronic renal allograft rejection in the rat. (4/145)

Chronic rejection is the leading cause of late renal transplant failure. Various structural lesions are observed in grafts undergoing chronic rejection including glomerular basement membrane (GBM) duplications. The well-established Fisher (F344) to Lewis (LEW) rat renal transplant model for chronic rejection was used to assess the presence and role of the humoral immune response against graft antigens during chronic rejection. LEW recipients of F344 allografts develop transplant glomerulopathy and produce IgG1 antibodies directed against F344 GBM preparations that are detectable 3 weeks after transplantation. Glomerular IgG1 deposition was observed that in vitro co-localized with a rabbit anti-rat GBM antiserum in rejecting F344 grafts; elution experiments of isolated glomeruli yielded IgG1 antibodies reactive in vitro with F344 GBM, but not LEW GBM. Prevention of acute rejection by transient treatment of the recipients with cyclosporin A completely abrogated the production of anti-GBM antibodies. Using proteomic techniques we identified the antigens recognized by the LEW posttransplant sera as being the heparan sulfate proteoglycan perlecan and the alpha1 chain of collagen type VI in association with the alpha5 chain of collagen type IV. In conclusion, LEW recipients of F344 kidney grafts produce IgG1 antibodies against donor type perlecan and alpha1(VI)/alpha5(IV) collagen and develop transplant glomerulopathy. These data implicate an important role for the humoral immune response in the development of glomerulopathy during chronic rejection.  (+info)

The influence of the pericellular microenvironment on the chondrocyte response to osmotic challenge. (5/145)

OBJECTIVE: To examine whether differences in the pericellular microenvironment of different chondron preparations influence the chondrocyte volume regulatory response to experimental osmotic challenge. DESIGN: Mechanically extracted chondrons (MC), enzymatically extracted chondrons (EC) and isolated chondrocytes (IC) were seeded into agarose and sampled at 1, 3 and 7 days. Samples mounted in a perfusion chamber were subjected to osmotic challenge. The cross-sectional areas of the chondrocyte and pericellular microenvironment were measured under isotonic, hypertonic and hypotonic conditions, and percentage change calculated. Separate samples were immunolabeled for type VI collagen and keratan sulfate. RESULTS: Initially, the microenvironment of MC represented 60% of the chondron area and was occupied by type VI collagen and keratan sulfate. In EC, the microenvironment comprised 18% of the chondron area with narrow bands of type VI collagen and keratan sulfate. IC had no visible microenvironment, with small amounts of type VI collagen and keratan sulfate present. All preparations sequestered additional pericellular macromolecules during culture. Under isotonic conditions, the EC and IC chondrocytes were larger than those of MC. All chondrocytes shrank under hypertonic conditions and swelled under hypotonic conditions. MC were the least responsive, displaying the most efficient volume regulation. IC showed the largest response initially but this decreased with time. EC exhibited intermediate responses that decreased as the microenvironment increased in size. CONCLUSIONS: The composition and structural integrity of the pericellular microenvironment do influence the cellular response to experimental osmotic challenge. This suggests that the microenvironment functions in situ to mediate the chondrocyte response to physicochemical changes associated with joint loading.  (+info)

Mutations in COL6A3 cause severe and mild phenotypes of Ullrich congenital muscular dystrophy. (6/145)

Ullrich congenital muscular dystrophy (UCMD) is an autosomal recessive disorder characterized by generalized muscular weakness, contractures of multiple joints, and distal hyperextensibility. Homozygous and compound heterozygous mutations of COL6A2 on chromosome 21q22 have recently been shown to cause UCMD. We performed a genomewide screening with microsatellite markers in a consanguineous family with three sibs affected with UCMD. Linkage of the disease to chromosome 2q37 was found in this family and in two others. We analyzed COL6A3, which encodes the alpha3 chain of collagen VI, and identified one homozygous mutation per family. In family I, the three sibs carried an A-->G transition in the splice-donor site of intron 29 (6930+5A-->G), leading to the skipping of exon 29, a partial reduction of collagen VI in muscle biopsy, and an intermediate phenotype. In family II, the patient had an unusual mild phenotype, despite a nonsense mutation, R465X, in exon 5. Analysis of the patient's COL6A3 transcripts showed the presence of various mRNA species-one of which lacked several exons, including the exon containing the nonsense mutation. The deleted splice variant encodes collagen molecules that have a shorter N-terminal domain but that may assemble with other chains and retain a functional role. This could explain the mild phenotype of the patient who was still ambulant at age 18 years and who showed an unusual combination of hyperlaxity and finger contractures. In family III, the patient had a nonsense mutation, R2342X, causing absence of collagen VI in muscle and fibroblasts, and a severe phenotype, as has been described in patients with UCMD. Mutations in COL6A3 are described in UCMD for the first time and illustrate the wide spectrum of phenotypes which can be caused by collagen VI deficiency.  (+info)

Isolation of up- or down-regulated genes in PPARgamma-expressing NIH-3T3 cells during differentiation into adipocytes. (7/145)

Adipocyte differentiation is a complex process in which the expression of many transcription factors and adipocyte-specific genes is regulated under a strict program. The peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the steroid/thyroid nuclear hormone receptor superfamily of ligand-activated transcription factors, is an important regulator of adipocyte gene expression and differentiation. In this study, we tried to identify downstream target genes of PPARgamma, by using PPARgamma-expressing cells and a subtractive cloning strategy, and isolated cDNA clones which were up-regulated or down-regulated by PPARgamma. Northern blot analyses revealed that the expression levels of the aldehyde dehydrogenase-2-like, type VI collagen alpha 3 subunit, cellular retinoic acid binding protein 1 and thrombospondin 1 are changed during the differentiation of mouse 3T3-L1 preadipocyte cells, indicating that these genes might be downstream targets of PPARgamma in adipocyte differentiation.  (+info)

Identification of known and novel genes whose expression is regulated by endogenous retinoic acid during early embryonic development of the mouse. (8/145)

Retinoic acid (RA) derived from vitamin A is necessary for, among other things, mammalian embryonic development. Although the impact of RA-dependent gene-regulation on embryonic development has been examined through genetic disruption of the retinoid receptors, the understanding of the underlying molecular mechanism remain unclear, in part, due to the difficulty in identifying RA-regulated genes in an intact embryo. We report here that RA-regulated genes can be identified from total RA-deficient embryos created by retinol-binding protein antisense (RBP-AS) oligodeoxynucleotide treatment in conjunction with differential display. Of the 28 genes isolated, 15 genes matched known genes in the GenBank database and the others either represented EST sequences or encoded novel genes. Semi-quantitative reverse transcriptase-polymerase chain reaction verified that the mRNA levels of mouse DN 38, COL VI 3 alpha, cul-1, alpha-tropomyosin, and PP2A-C alpha were substantially increased, whereas mouse Msh 2, Ndufa2, Ribosomal protein S19, sFRP-1, GDAP-10 and mSmcD were significantly decreased in vitamin A deficient (VAD) embryos compared to the control embryos. The utility of the method is exemplified by our finding that several genes in the Wnt signaling pathway are vitamin A regulated in day 9.0 post coitum (p.c.) embryos.  (+info)

GARD : 20 Ullrich congenital muscular dystrophy is a condition that mainly affects skeletal muscles (the muscles used for movement). Affected individuals show severe muscle weakness soon after birth, develop stiff joints ( contractures ) in their knees and elbows, and may have an unusual range of movement ( hypermobility ) in their wrists and ankles. This condition is caused by mutations in the COL6A1, COL6A2, and COL6A3 genes. Ullrich congenital muscular dystrophy is typically inherited in an autosomal recessive pattern. In rare cases, this condition may be inherited in an autosomal dominant pattern ...
Collagen VI is widely distributed throughout extracellular matrices (ECMs) in various tissues. In skeletal muscle, collagen VI is particularly concentrated in and adjacent to basement membranes of myofibers. Ullrich congenital muscular dystrophy (UCMD) is caused by mutations in either COL6A1, COL6A2 or COL6A3 gene, thereby leading to collagen VI deficiency in the ECM. It is known to occur through either recessive or dominant genetic mechanism, the latter most typically by de novo mutations. UCMD is well defined by the clinicopathological hallmarks including distal hyperlaxity, proximal joint contractures, protruding calcanei, scoliosis and respiratory insufficiency. Recent reports have depicted the robust natural history of UCMD; that is, loss of ambulation by early teenage years, rapid decline in respiratory function by 10 years of age and early-onset, rapidly progressive scoliosis. Muscle pathology is characterised by prominent interstitial fibrosis disproportionate to the relative paucity of ...
International peer-reviewed papers [5] Optimized probe masking for comparative transcriptomics of closely related species. (Pöschl Y, Delker C, Trenner J, Ullrich KK, Quint M, Grosse I) Plos ONE 2013 Nov 08. [4] Toward a comprehensive phylogenetic reconstruction of the evolutionary history of mitogen-activated protein kinases in the plant kingdom. (Janitza P, Ullrich KK, Quint M) frontiers in PLANT SCIENCE 2012 Dec 06. [3] A transcriptomic hourglass in plant embryogenesis. (Quint M, Drost H-G, Gabel A, Ullrich KK, Boenn M, Grosse I) Nature 2012 Oct 04. [2] Molecular Evolution and Selection Patterns of Plant F-box Proteins with C-terminal Kelch Repeats. (Schumann N, Navarro-Quezada AR, Ullrich K, Kuhl C and Quint M) Plant Physiology 2011 Feb. [1] Natural Variation of Transcriptional Auxin Response Networks in Arabidopsis thaliana. (Delker C, Pöschl Y, Raschke A, Ullrich K, Ettingshausen S, Hauptmann V, Grosse I, Quint M) Plant Cell. 2010 Jul 09. Theses Ullrich KK 2013. Population and ...
International peer-reviewed papers [5] Optimized probe masking for comparative transcriptomics of closely related species. (Pöschl Y, Delker C, Trenner J, Ullrich KK, Quint M, Grosse I) Plos ONE 2013 Nov 08. [4] Toward a comprehensive phylogenetic reconstruction of the evolutionary history of mitogen-activated protein kinases in the plant kingdom. (Janitza P, Ullrich KK, Quint M) frontiers in PLANT SCIENCE 2012 Dec 06. [3] A transcriptomic hourglass in plant embryogenesis. (Quint M, Drost H-G, Gabel A, Ullrich KK, Boenn M, Grosse I) Nature 2012 Oct 04. [2] Molecular Evolution and Selection Patterns of Plant F-box Proteins with C-terminal Kelch Repeats. (Schumann N, Navarro-Quezada AR, Ullrich K, Kuhl C and Quint M) Plant Physiology 2011 Feb. [1] Natural Variation of Transcriptional Auxin Response Networks in Arabidopsis thaliana. (Delker C, Pöschl Y, Raschke A, Ullrich K, Ettingshausen S, Hauptmann V, Grosse I, Quint M) Plant Cell. 2010 Jul 09. Theses Ullrich KK 2013. Population and ...
The Max Planck Institute of Biochemistry has launched the Axel Ullrich Lecture in honor of its member, world-renowned researcher and entrepreneur Axel Ullrich. He discovered numerous oncogenes and meticulously described how they transform cells. He was enormously successful in bringing his discoveries from the bench to the bedside. Anti-cancer drugs like Herceptin and Sutent benefited cancer patients worldwide.. The annual Axel Ullrich Lecture is presented by an eminent researcher around Axel Ullrichs birthday in October. The Lecturer is selected by the faculty of the Max Planck Institute of Biochemistry. Speakers at the Lecture receive the Axel Ullrich Medal.. ...
Top of Her Game by M. Ullrich Top of Her Game M. Ullrich Page: 240 Format: pdf, ePub, mobi, fb2 ISBN: 9781635555004 Publisher: Bold Strokes Books Download eBook Free ebooks
Last Saturday March 25, a fun day was held at Rye Sports Centre in aid of raising funds for a special 4×4 wheelchair for a young Tilling green resident Mason Skinner.. Ten-year-old Mason has a rare form of muscular dystrophy, called collagen VI deficiency. He currently uses an electric wheelchair each day. But, because of the type of chair Mason uses, he is limited as to where he can go. So the new 4×4 chair would allow Mason the freedom to go almost anywhere independently with or without the family.. There were stalls run by the local Guides, Brownies and Rother Youth Group as well as a stall selling candles run by Clair Debley Turner, facepainting, a tombola, guess the weight of the cake, name the teddy, penalty kicks (run by Andy Stoodley) and a raffle comprising prizes collected from local shops.. The day also had a couple of events for which participants had to obtain sponsors and Shalimar Skinner (Masons sister) and Brownie leader Emily Hall both did a sponsored swim.. The other ...
Humphrey, E L and Lacey, E and Le, L T and Feng, L and Sciandra, F and Morris, C R and Hewitt, J E and Holt, I and Brancaccio, A and Barresi, R and Sewry, C A and Brown, S C and Morris, G E (2015) A new monoclonal antibody DAG-6F4 against human alpha-dystroglycan reveals reduced core protein in some, but not all, dystroglycanopathy patients. Neuromuscular Disorders, 25 (1). pp. 32-42. Humphrey, E L and Lacey, E and Le, L T and Sciandra, F and Morris, C and Hewitt, J E and Holt, I and Brancaccio, A and Barresi, R and Sewry, C A and Brown, S C and Morris, G E (2014) A NEW MONOCLONAL ANTIBODY AGAINST HUMAN ALPHA-DYSTROGLYCAN HAS POTENTIAL DIAGNOSTIC APPLICATIONS. Neuromuscular Disorders, 24 (9-10). p. 918. Kim, J and Jimenez-Mallebrera, C and Foley, A R and Fernandez-Fuente, M and Brown, S C and Torelli, S and Feng, L and Sewry, C A and Muntoni, F (2012) Flow cytometry analysis: a quantitative method for collagen VI deficiency screening. Neuromuscular Disorders, 22 (2). pp. 139-48. ...
Herranz, R; Anken, R; Boonstra, J; Braun, M; Christianen, P C M; de Geest, M; Hauslage, J; Hilbig, R; Hill, R J A; Lebert, M; Medina, F J; Vagt, N; Ullrich, O; van Loon, J W A; Hemmersbach, R (2013). Ground-based facilities for simulation of microgravity: organism-specific recommendations for their use, and recommended terminology. Astrobiology, 13(1):1-17.. Adrian, A; Schoppmann, K; Sromicki, J; Brungs, S; von der Wiesche, M; Hock, B; Kolanus, W; Hemmersbach, R; Ullrich, O (2013). The oxidative burst reaction in mammalian cells depends on gravity. Cell Communication and Signaling, 11:98.. Horn, A; Ullrich, O; Huber, K; Hemmersbach, R (2011). PMT (Photomultiplier) Clinostat. Microgravity Science and Technology, 23(1):67-71.. Paulsen, K; Thiel, C; Timm, J; Schmidt, P M; Schoppmann, K; Tauber, S; Hemmersbach, R; Seibt, D; Kroll, H; Grote, K H; Zipp, F; Schneider-Stock, R; Cogoli, A; Hilliger, A; Engelmann, F; Ullrich, O (2010). Microgravity-induced alterations in signal transduction in cells of ...
Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Complete information for COL6A1 gene (Protein Coding), Collagen Type VI Alpha 1 Chain, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Nel presente lavoro, abbiamo effettuato unanalisi sistematica di 22 biopsie muscolari ottenute da pazienti affetti da COL6RD e 14 biopsie muscolari ottenuti da controlli sani di età corrispondente, che sono state suddivise in base al grado di atrofia muscolare e fibrosi. Questa classificazione è stata effettuata usando un algoritmo originale per lanalisi automatica di preparazioni istologiche, ed ha generato 3 gruppi, COL6RD-1, COL6RD-2 and COL6RD-3, di gravità istologica crescente. Le stesse biopsie sono state sottoposte a microarray e RNA-Seq ed hanno rivelato andamenti di espressione genica in forte correlazione con i gruppi definiti secondo secondo i preparati istologici, sottolineando la chiara divisione tra le biopsie muscolari di individui affetti da COL6RD e controlli. Lanalisi in silico dellespressione genica ha successivamente rivelato TGFβ1 come il maggior responsabile dei cambiamenti istologici in COL6RD e, verosimilmente, dei processi patofisiologici sottostanti. Il ...
ROG has upped the game audio ante with an advanced differential circuit design. It includes an Op-Amp that combines two opposite-phased signals while filtering out noise interference during transmission, providing clear audio stream output with double the intensity. Moreover, SupremeFX on Maximus VI GENE also implements multi-approach shielding, with ELNA audio capacitors helping offer 8-channel HD sound thats equal in power, clarity, and range to dedicated sound cards. This is the first-ever onboard sound capable of true audiophile-grade performance, set to revolutionize the way you hear games, movies, music, and even other people via chat. Discover a whole new dimension of superior audio and get ready to rule. Click the button to learn more about SupremeFX!. ...
url=https://www.userbenchmark.com/UserRun/16232978]UserBenchmarks: Game 109%, Desk 90%, Work 90%[/url] CPU: [url=https://cpu.userbenchmark.com/Intel-Core-i7-4770K/Rating/1537]Intel Core i7-4770K[/url] - [b]90.5%[/b] GPU: [url=https://gpu.userbenchmark.com/Nvidia-RTX-2080/Rating/4026]Nvidia RTX 2080[/url] - [b]124%[/b] SSD: [url=https://ssd.userbenchmark.com/SpeedTest/1478/Intel-Raid-0-Volume]Intel Raid 0 Volume 240GB[/url] - [b]96.7%[/b] HDD: [url=https://hdd.userbenchmark.com/SpeedTest/1724/Intel-Raid-0-Volume]Intel Raid 0 Volume 2TB[/url] - [b]167.7%[/b] RAM: [url=https://ram.userbenchmark.com/SpeedTest/89208/Corsair-Vengeance-Pro-CMY16GX3M2A1866C9-2x8GB]Corsair Vengeance Pro DDR3 1866 C9 2x8GB[/url] - [b]73.2%[/b] MBD: [url=https://www.userbenchmark.com/System/Asus-MAXIMUS-VI-GENE/546]Asus MAXIMUS VI GENE[/url ...
Die kürzlich beschriebenen SPRED- (Sprouty-related protein with EVH-1 domain) Proteine gehören zu einer Familie von membranassoziierten Proteinen mit einer N-terminalen EVH-1- (Ena/VASP Homology-1) Domäne, einer C-terminalen cysteinreichen, Sprouty-ähnlichen (SPR) Domäne und einer c-Kit-bindenden mittleren Domäne (KBD). Im Ras/Raf/MAP-Kinase-Signalweg, der vor allem für die Proliferation und Differenzierung von Zellen bedeutend ist, haben SPRED-Proteine eine inhibitorische Funktion, indem sie u.a. an Raf binden und die Aktivierung des MAPK-Signalwegs inhibieren. Um die physiologische Bedeutung der SPRED-Proteine erfassen zu können, haben wir mittels einem gene trap-Ansatz SPRED-2-defiziente Mäuse erstellt und die Auswirkungen der Gendefizienz auf den Organismus untersucht. Die Tiere zeigen Minderwuchs, pathologische Veränderungen der Nieren und Lymphknoten und versterben i.d.R. innerhalb des ersten Lebensjahrs. Ziel dieses Projekts ist es nun die Ursachen für diese phänptypischen ...
Frankly it rings true for me. Does anyone remember how good Jan was at the start of his pro career? I do - he was unbelievably good before he rode Le Tour - and clearly a Tour-rider, not a classics-rider in the making (although he was talented enough to do well there if he wanted). So what he achieved in his career was pretty well consistent- no sudden rise to the top - well OK, he did fabulously well at his first TdF - but generally it was obvious that he was someone who could climb, TT and race day after day. He was in the mould, as it were, of the past greats. Now is that always true? I guess not, and it proves nothing about those who suddenly converted from OK to above-average classics-rider to stunning Tour rider - but it does make one wonder. ...
Krystle is a 30-year-old professional patient and mom of 2 girls. All 3 share multiple complex and rare medical conditions including bethlem myopathy type 2.
PLoS One 2017, 12(12):e0189510. PMID: 29245157.. Lang D., Ullrich K.K., Murat F., Fuchs J., Jenkins J., Haas F.B., Piednoel M., Gundlach H., Van Bel M., Meyberg R., Vives C., Morata J., Symeonidi A., Hiss M., Muchero W., Kamisugi Y., Saleh O., Blanc G., Decker E.L., van Gessel N., Grimwood J., Hayes R.D., Graham S.W., Gunter L.E., McDaniel S., Hoernstein S.N.W., Larsson A., Li F.W., Perroud P.F., Phillips J., Ranjan P., Rokshar D.S., Rothfels C.J., Schneider L., Shu S., Stevenson D.W., Thümmler F., Tillich M., Villarreal A J.C., Widiez T., Wong G.K., Wymore A., Zhang Y., Zimmer A.D., Quatrano R.S., Mayer K.F.X., Goodstein D., Casacuberta J.M., Vandepoele K., Reski R., Cuming A.C., Tuskan J., Maumus F., Salse J., Schmutz J. & Rensing S.A.: The P. patens chromosome-scale assembly reveals moss genome structure and evolution ...
Leebens-Mack, J. H.; Barker, M. S.; Carpenter, E. J.; Deyholos, M. K.; Gitzendanner, M. A.; Graham, S. W.; Grosse, I.; Li, Z.; Melkonian, M.; Mirarab, S. et al.; Porsch, M.; Quint, M.; Rensing, S. A.; Soltis, D. E.; Soltis, P. S.; Stevenson, D. W.; Ullrich, K. K.; Wickett, N. J.; DeGironimo, L.; Edger, P. P.; Jordon-Thaden, I. E.; Joya, S.; Liu, T.; Melkonian, B.; Miles, N. W.; Pokorny, L.; Quigley, C.; Thomas, P.; Villarreal, J. C.; Augustin, M. M.; Barrett, M. D.; Baucom, R. S.; Beerling, D. J.; Benstein, R. M.; Biffin, E.; Brockington, S. F.; Burge, D. O.; Burris, J. N.; Burris, K. P.; Burtet-Sarramegna, V.; Caicedo, A. L.; Cannon, S. B.; Çebi, Z.; Chang, Y.; Chater, C.; Cheeseman, J. M.; Chen, T.; Clarke, N. D.; Clayton, H.; Covshoff, S.; Crandall-Stotler, B. J.; Cross, H.; dePamphilis, C. W.; Der, J. P.; Determann, R.; Dickson, R. C.; Stilio, D.; S., V.; Ellis, S.; Fast, E.; Feja, N.; Field, K. J.; Filatov, D. A.; Finnegan, P. M.; Floyd, S. K.; Fogliani, B.; García, N.; Gâteblé, G.; ...
Leebens-Mack, J. H.; Barker, M. S.; Carpenter, E. J.; Deyholos, M. K.; Gitzendanner, M. A.; Graham, S. W.; Grosse, I.; Li, Z.; Melkonian, M.; Mirarab, S. et al.; Porsch, M.; Quint, M.; Rensing, S. A.; Soltis, D. E.; Soltis, P. S.; Stevenson, D. W.; Ullrich, K. K.; Wickett, N. J.; DeGironimo, L.; Edger, P. P.; Jordon-Thaden, I. E.; Joya, S.; Liu, T.; Melkonian, B.; Miles, N. W.; Pokorny, L.; Quigley, C.; Thomas, P.; Villarreal, J. C.; Augustin, M. M.; Barrett, M. D.; Baucom, R. S.; Beerling, D. J.; Benstein, R. M.; Biffin, E.; Brockington, S. F.; Burge, D. O.; Burris, J. N.; Burris, K. P.; Burtet-Sarramegna, V.; Caicedo, A. L.; Cannon, S. B.; Çebi, Z.; Chang, Y.; Chater, C.; Cheeseman, J. M.; Chen, T.; Clarke, N. D.; Clayton, H.; Covshoff, S.; Crandall-Stotler, B. J.; Cross, H.; dePamphilis, C. W.; Der, J. P.; Determann, R.; Dickson, R. C.; Stilio, D.; S., V.; Ellis, S.; Fast, E.; Feja, N.; Field, K. J.; Filatov, D. A.; Finnegan, P. M.; Floyd, S. K.; Fogliani, B.; García, N.; Gâteblé, G.; ...
J Alzheimers Dis 27: 701-709. Keck S, Nitsch R, Grune defence, Ullrich O( 2003) inflammatory email by funded several pathogenesis in standards of negotiations with Alzheimers state. Tseng BP, Green KN, Chan JL, Blurton-Jones M, LaFerla FM( 2008) Abeta is the management and is level and teacher version.
Dr. Anna Ullrich in conversation with some former EHRI fellows during the conference Holocaust Studies in its Social Setting, on July 3, 2019 in Amsterdam. (Photo Marc Nauwen/EHRI)
Magdalena Koziczak-Holbro, Dean F. Rigel, Bérengère Dumotier, David A. Sykes, Jeffrey Tsao, Ngoc-Hong Nguyen, Julian Bösch, Marie Jourdain, Ludivine Flotte, Yuichiro Adachi, Michael Kiffe, Moïse Azria, Robin A. Fairhurst, Steven J. Charlton, Brian P. Richardson, Estelle Lach-Trifilieff, David J. Glass, Thomas Ullrich and Shinji Hatakeyama ...
Martin L. Sos, Felix Dietlein, Martin Peifer, Jakob Schöttle, Hyatt Balke-Want, Christian Müller, Mirjam Koker, André Richters, Stefanie Heynck, Florian Malchers, Johannes M. Heuckmann, Danila Seidel, Patrick A. Eyers, Roland T. Ullrich, Andrey P. Antonchick, Viktor V. Vintonyak, Peter M. Schneider, Takashi Ninomiya, Herbert Waldmann, Reinhard Büttner, Daniel Rauh, Lukas C. Heukamp, and Roman K. Thomas ...
Silbernagel N, Körner A, Balitzki J, Jaggy M, Bertels S, Richter B, Hippler M, Hellwig A, Hecker M, Bastmeyer M, Ullrich ND. Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds. Biomaterials. 2020 Jan;227:119551. doi: 10.1016/j.biomaterials.2019.119551. Epub 2019 Oct 19.. ...
Silbernagel N, Körner A, Balitzki J, Jaggy M, Bertels S, Richter B, Hippler M, Hellwig A, Hecker M, Bastmeyer M, Ullrich ND. Shaping the heart: Structural and functional maturation of iPSC-cardiomyocytes in 3D-micro-scaffolds. Biomaterials. 2020 Jan;227:119551. doi: 10.1016/j.biomaterials.2019.119551. Epub 2019 Oct 19.. ...
inproceedings{Peckhaus_2004, place={Augsburg}, series={Algorismus}, title={,Aber vielleicht kommt noch eine Zeit, wo auch meine Arbeiten wieder entdeckt und gelesen werde: Die gescheiterte Karriere des Ernst Zermelo}, volume={44}, booktitle={Mathematik im Fluß der Zeit. Tagung zur Geschichte der Mathematik in Attendorn/Neu-Listernohl (28.5. bis 1.6.2003)}, publisher={ERV Dr. Erwin Rauner Verlag}, author={Peckhaus, Volker}, editor={Hein, Wolfgang and Ullrich, PeterEditors}, year={2004}, pages={325-339}, collection={Algorismus ...
Duitman EH, Hamoen LW, Rembold M, Venema G, Seitz H, Saenger W, Bernhard F, Reinhardt R, Schmidt M, Ullrich C, Stein T, Leenders F, Vater J ...
Gerst, Felicia; Kaiser, Gabriele; Panse, Madhura; Heni, Martin; Sartorius, Tina; Sipos, Bence; Fend, Falko; Thiel, Christian; Nadalin, Silvio; Stefan, Norbert; Ullrich, Susanne; Wagner, Róbert; Machann, Jürgen; Bongers, Malte Niklas; Königsrainer, Alfred; Fritsche, Andreas Erwin; Häring, Hans-Ulrich; Siegel-Axel, Dorothea Ilse (Springer, 2017) ...
Duitman EH, Hamoen LW, Rembold M, Venema G, Seitz H, Saenger W, Bernhard F, Reinhardt R, Schmidt M, Ullrich C, Stein T, Leenders F, Vater J ...
Siegel-Axel, Dorothea Ilse; Ullrich, Susanne; Stefan, Norbert; Rittig, Kilian; Gerst, Felicia; Klingler, Christian; Schmidt, Ulrike; Schreiner, Birgit; Randrianarisoa, Elko; Schaller, Hans-Eberhard; Weigert, Cora; Stock, Ulrich Alfred; Königsrainer, Alfred; Häring, Hans-Ulrich (Springer, 2014) ...
Lena Schleier, Maximilian Wiendl, Karin Heidbreder, Marie-Theres Binder, Raja Atreya, Timo Rath, Emily Becker, Anja Schulz-Kuhnt, Annette Stahl, Lisa Lou Schulze, Karen Ullrich, Simon F Merz, Lea Bornemann, Matthias Gunzer, Alastair J M Watson, Clemens Neufert, Imke Atreya, Markus F Neurath, Sebastian Zundler ...
If the road to hell is paved with good intentions, that path may well cut through the fetid halls of Bethlem Hospital. The institution began as a priory
АДСОРБЦІЯ ІОНІВ Cr (VI) ТА Co (II) ПАЛИГОРСЬКІТОМ, МОДИФІКОВАНИМ КАТІОННИМИ ПОВЕРХНЕВО- АКТИВНИМИ РЕЧОВИНАМИ
Ehitusterritooriumi märgised, kolm lõvi ohutus, ehitus, ehitusterritoorium, ehitusplats, ohutusmärk, ohutusmärgistus, ohutusmärgid
article{6b8e8868-1afd-41d6-808d-4fc5532ec3af, abstract = {The ability of the leucine-rich repeat (LRR) proteins biglycan, decorin and chondroadherin to interact with collagen VI and influence its assembly to supramolecular structures was studied by electron microscopy and surface plasmon resonance measurements in the BIAcore 2000 system. Biglycan showed a unique ability to organize collagen VI into extensive hexagonal-like networks over a time period of only a few minutes. Only the intact molecule, substituted with two dermatan sulfate chains, had this capacity. Intact decorin, with one dermatan sulfate chain only, was considerably less efficient and aggregates of organized collagen VI were found only after several hours. Chondroadherin without glycosaminoglycan substitutions did not induce any ordered collagen VI organization. However, all three related LRR proteins were shown to interact with collagen VI using electron microscopy and surface plasmon resonance. Biglycan and decorin were ...
Bethlem Asylum, also known as Bethlem Royal Hospital, is a Victorian England location featured on ABCs Once Upon a Time in Wonderland. It first appears in the first episode. Bethlem Asylum is inspired by the real life Bethlem Royal Hospital in London. This article or section needs more history...
To address some of the key challenges among patients with congenital muscular dystrophy type Ullrich with an aim of developing temporary treatment approaches, doctors need to appreciate complication that characterizes the life experience of the patients. In reference to Bolduc paper and Shens publications, I have highlighted these challenges that are key in defining the modifications of treatment protocols.. First, living with a genetic disease means a lifetime experience of treatment and medical attention, an experience that mostly characterizes the lives of patients with congenital muscular dystrophy type Ullrich (UCMD). The condition is common among children in their early childhood stages and is characterized by severe disorders that arise from weakened muscles. Bolduc paper appreciates that the condition does not have permanent treatments, a position that poses a significant challenge to the health of the patients.. Another equally great concern among the patients is the financial ...
Dr. Thomas John Kehle, 74, of Willington, died on Wednesday, February 7th, 2018, at Manchester Memorial Hospital. He leaves behind his wife of 56-years, Gretchen Kehle; grandchildren, Megan and Matthew Dwyer; brothers, Gregory Kehle and Anthony Kehle; and sister Pamela Kehle Schwantes; as well as many nieces and nephews. He is preceded in death by his beloved daughter, Deborah G. Kehle; mother, Genevieve; father, Anthony; and brother James. Professor and Director of the School Psychology Program at The University of Connecticut since 1987, he previously worked as a Professor at Kent State University and The University of Utah. Dr. Kehle graduated from Pompano Beach High School and... ...
TY - JOUR. T1 - Overexpression of type VI collagen in neoplastic lung tissues. AU - Voiles, Larry. AU - Lewis, David E.. AU - Han, Ling. AU - Lupov, Ivan P.. AU - Lin, Tsang Long. AU - Robertson, Michael J.. AU - Petrache, Irina. AU - Chang, Hua Chen. PY - 2014/11/1. Y1 - 2014/11/1. N2 - Type VI collagen (COL6), an extracellular matrix protein, is important in maintaining the integrity of lung tissue. An increase in COL6 mRNA and protein deposition was found in the lungs of patients with pulmonary fibrosis, a chronic inflammatory condition with a strong association with lung cancer. In the present study, we demonstrated overexpression of COL6 in the lungs of non-small cell lung cancers. We hypothesized that excessive COL6 in the lung interstitium may exert stimulatory effects on the adjacent cells. In vitro stimulation of monocytes with COL6 resulted in the production of IL-23, which may promote tumor development in an environment of IL-23-mediated lung inflammation, where tissue modeling occurs ...
Congenital muscular dystrophy (CMD) affects muscles and breathing. Some people with CMD don t have enough muscle proteins like laminin alpha 2 (LAMA2) or collagen VI (COLVI). The new drug Omigapil may help these people. Participants will be screened with medical history, physical exam, and heart, blood, and urine tests.. ...
Title:A milder phenotype of megaconial congenital muscular dystrophy due to a novel CHKB mutation.,Author:De Fuenmayor-Fernández De La Hoz Carlos Pablo,Domínguez-González Cristina,Gonzalo-Martínez Jua...
CR: My whole research career, as PI (principal investigator) has been here at the University of Vermont, and Ive been concentrating on the mating-type genes of Schizophyllum. I started in collaboration with a former graduate student of my husbands, Bob Ullrich, and his buddy, Charles Novotny, who was in the department I joined here. And they each had graduate students, so it was like a little colony of us studying the genetics of mating in Schizophyllum. Here, at the University of Vermont, Ullrich and Novotny were working on the A mating type system, and found that it involves genes encoding something called homeodomain proteins that are DNA transcription regulators similar to a host of comparable genes used for developmental processes throughout the animal kingdom. So his group was working on that, and my lab was working on the B system which we, along with Drs. Erika Kothe and Marjatta Raudaskovsky, found involves genes for pheromones and pheromone receptors. The neat thing we found at these ...
Kopf A, Bicak M, Kottmann R, Schnetzer J, Kostadinov I, Lehmann K, Fernandez-Guerra A, Jeanthon C, Rahav E, Ullrich M, Wichels A, Gerdts G, Polymenakou P, Kotoulas G, Siam R, Abdallah R.Z, Sonnenschein E.C, Cariou T, OGara F, Jackson S, Orlic S, Steinke M, Busch J, Duarte B, Cacador I, Canning-Clode J, Bobrova O, Marteinsson V, Reynisson E, Loureiro C.M, Luna G.M, Quero G.M, Loscher C.R, Kremp A, DeLorenzo M.E, Ovreas L, Tolman J, LaRoche J, Penna A, Frischer M, Davis T, Katherine B, Meyer C.P, Ramos S, Magalhaes C, Jude-Lemeilleur F, Aguirre-Macedo M.L, Wang S, Poulton N, Jones S, Collin R, Fuhrman J.A, Conan P, Alonso C, Stambler N, Goodwin K, Yakimov M.M, Baltar F, Bodrossy L, Van De Kamp J, Frampton D.M.F, Ostrowski M, Van Ruth P, Malthouse P, Claus S, Deneudt K, Mortelmans J, Pitois S, Wallom D, Salter I, Costa R, Schroeder D.C, Kandil M.M, Amaral V, Biancalana F, Santana R, Pedrotti M.L, Yoshida T, Ogata H, Ingleton T, Munnik K, Rodriguez-Ezpeleta N, Berteaux-Lecellier V, Wecker P, Cancio ...
Collagen type 6 is a big protein complex that is synthesized using instructions from six different genes: COL6A1, COL6A2, COL6A3, COL6A4, COL6A5, and COL6A6. COL6A4 was separated into two pieces - COL6A4P1 and COL6A4P2 - by an ancient evolutionary gene rearrangement. COL6A4P1 encodes for a portion of the collagen type 6 complex, while COL6A4P2 is considered a pseudogene, which does not encode for a protein, but may be involved in regulating the expression of COL6A4P1.. Each of the collagen type 6 genes encodes for a small piece of the larger complex. As the individual components of the protein are made within cells, the collagen complex assembles in a complicated series of steps. Once assembled, the complex must be moved from the interior of the cell to the outside - a process called secretion or exocytosis. Outside of the cell, the completed collagen interacts with extracellular structural components - called the extracellular matrix or ECM - to form a bridge between cells and the surrounding ...
A distrofia muscular congênita (DMC) compõe um grupo de miopatias caracterizadas por hipotonia e fraqueza muscular notadas já no primeiro ano de vida. A forma de Ullrich é caracterizada por retrações musculares proximais e hiperextensibilidade distal. Cerca de 40% destes pacientes apresentam mutações em um dos genes que codificam as três sub-unidades do colágeno VI (COL6), acarretando deficiência total ou parcial na marcação da proteína. Analisamos, através de imunofluorescência, a marcação do COL6 em fragmentos musculares de 50 pacientes com DMC, 20 deles com ausência da marcação para merosina. Identificamos 4 casos com deficiência total da marcação do COL6 (8% do total), representando 13% dos casos com marcação normal para merosina. As alterações histológicas musculares dos pacientes com COL6 deficiente eram indistinguíveis das outras formas de DMC, porém mais brandas que as observadas na DMC com deficiência de merosina. Em três dos pacientes com COL6 ...
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A ski is a technically sophisticated piece of sports equipment, but it is also a highly aesthetic object that is optimized for top performance. The project at Audi Concept Design Munich - in the heart of the urban district Schwabing - was based on these considerations. The team of young, international designers was able to transfer the Audi design gene from the brands cars to the ski. Carbon and aluminum are central elements in Audi design - these exclusive materials underscore the outstanding quality of our cars, Egger said. The design of the ski also intentionally dispenses with unnecessary lines and concentrates fully on the material.. Thanks to its ideal combination of strength and light weight, carbon is used in motorsport for especially sensitive components that need to withstand the highest stress loads yet must at the same time be light in weight, says Dr. Wolfgang Ullrich, Head of Audi Motorsport. In the racing cars for the German Touring Car Masters (DTM) and the Le Mans sports ...
Zheng, Bin; Zhixiang Liao, Joseph J Locascio, Kristen A Lesniak, Sarah S Roderick, Marla L Watt, Aron C Eklund, Yanli Zhang-James, Peter D Kim, Michael A Hauser, Edna Grünblatt, Linda B Moran, Silvia A Mandel, Peter Riederer, Renee M Miller, Howard J Federoff, Ullrich Wüllner, Spyridon Papapetropoulos, Moussa B Youdim, Ippolita Cantuti-Castelvetri, Anne B Young, Jeffery M Vance, Richard L Davis, John C Hedreen, Charles H Adler, Thomas G Beach, Manuel B Graeber, Frank A Middleton, Jean-Christophe Rochet, Clemens R Scherzer, Global PD Gene Expression (GPEX) Consortium (2010-10-06). PGC-1α, a potential therapeutic target for early intervention in Parkinsons disease. Science translational medicine 2 (52): 52ra73. doi:10.1126/scitranslmed.3001059. ISSN 1946-6242. ...
The target of U3-1565 is a membrane-bound receptor tyrosine kinase ligand (RTKL), which is a key component of a molecular pathway, discovered and elucidated by Prof. Ullrich, involved in autocrine growth stimulation. U3 Pharma has demonstrated a pivotal role for U3-1565 in multiple cancer types of epithelial origin and has developed fully human therapeutic antibodies against the target under the company´s collaboration with Abgenix, now Amgen. The lead antibodies for this program are anticipated to enter the clinic in 2007.. U3-1900 ...
Hässler, T., Ullrich, J., Bernardino, M., Shnabel, N., Laar, C. V., Valdenegro, D., Sebben, S., Tropp, L. R., Visintin, E. P., González, R., Ditlmann, R. K., Abrams, D., Selvanathan, H. P., Branković, M., Wright, S., von Zimmermann, J., Pasek, M., Aydin, A. L., Žeželj, I., Pereira, A. y 23 otros, Lantos, N. A., Sainz, M., Glenz, A., Oberpfalzerová, H., Bilewicz, M., Kende, A., Kuzawinska, O., Otten, S., Maloku, E., Noor, M., Gul, P., Pistella, J., Baiocco, R., Jelic, M., Osin, E., Bareket, O., Biruski, D. C., Cook, J. E., Dawood, M., Droogendyk, L., Loyo, A. H., Kelmendi, K. & Ugarte, L. M., 1 abr 2020, En : Nature Human Behaviour. 4, 4, p. 380-386 7 p.. Resultado de la investigación ...
Nishiyama, T.; Sakayama, H.; de Vries, J.; Buschmann, H.; Saint-Marcoux, D.; Ullrich, K. K.; Haas, F. B.; Vanderstraeten, L.; Becker, D.; Lang, D.; Vosolsobě, S.; Rombauts, S.; Wilhelmsson, P. K. I.; Janitza, P.; Kern, R.; Heyl, A.; Rümpler, F; Calderón Villalobos, L. I. A.; Clay, J. M.; Skokan, R.; Toyoda, A.; Suzuki, Y.; Kagoshima, H.; Schijlen, E.; Tajeshwar, N.; Catarino, B.; Hetherington, A. J.; Saltykova, A.; Bonnot, C.; Breuninger, H.; Symeonidi, A.; Radhakrishnan, G. V.; Van Nieuwerburgh, F.; Deforce, D.; Chang, C.; Karol, K. G.; Hedrich, R.; Ulvskov, P.; Glöckner, G.; Delwiche, C. F.; Petrášek, J.; Van de Peer, Y.; Friml, J.; Beilby, M.; Dolan, L.; Kohara, Y.; Sugano, S.; Fujiyama, A.; Delaux, P.-M.; Quint, M.; Theißen, G.; Hagemann, M.; Harholt, J.; Dunand, C.; Zachgo, S.; Langdale, J.; Maumus, F.; Van Der Straeten, D.; Gould, S. B.; Rensing, S. A. The Chara Genome: Secondary Complexity and Implications for Plant Terrestrialization Cell 174, 448-464.e24, (2018) DOI: ...
Nishiyama T, Sakayama H, De Vries J, Buschmann H, Saint Marcoux D, Ullrich K, Haas F, Vanderstraeten L, Becker D, Lang D, Vosolsobě S, Rombauts S, Wilhelmsson P, Janitza P, Kern R, Heyl A, Rümpler F, Calderón Villalobos L, Clay J, Skokan R, Toyoda A, Suzuki Y, Kagoshima H, Schijlen E, Tajeshwar N, Catarino B, Hetherington A, Saltykova A, Bonnot C, Breuninger H, Symeonidi A, Radhakrishnan G, Van Nieuwerburgh F, Deforce D, Chang C, Karol K, Hedrich R, Ulvskov P, Glöckner G, Delwiche C, Petrášek J, Van De Peer Y, Friml J, Beilby M, Dolan L, Kohara Y, Sugano S, Fujiyama A, Delaux PM, Quint M, Theissen G, Hagemann M, Harholt J, Dunand C, Zachgo S, Langdale J, Maumus F, Van Der Straeten D, Gould SB, Rensing S. 2018. The Chara genome: Secondary complexity and implications for plant terrestrialization. Cell. 174(2), 448-464.e24 ...
Nishiyama, T.; Sakayama, H.; de Vries, J.; Buschmann, H.; Saint-Marcoux, D.; Ullrich, K. K.; Haas, F. B.; Vanderstraeten, L.; Becker, D.; Lang, D.; Vosolsobě, S.; Rombauts, S.; Wilhelmsson, P. K. I.; Janitza, P.; Kern, R.; Heyl, A.; Rümpler, F; Calderón Villalobos, L. I. A.; Clay, J. M.; Skokan, R.; Toyoda, A.; Suzuki, Y.; Kagoshima, H.; Schijlen, E.; Tajeshwar, N.; Catarino, B.; Hetherington, A. J.; Saltykova, A.; Bonnot, C.; Breuninger, H.; Symeonidi, A.; Radhakrishnan, G. V.; Van Nieuwerburgh, F.; Deforce, D.; Chang, C.; Karol, K. G.; Hedrich, R.; Ulvskov, P.; Glöckner, G.; Delwiche, C. F.; Petrášek, J.; Van de Peer, Y.; Friml, J.; Beilby, M.; Dolan, L.; Kohara, Y.; Sugano, S.; Fujiyama, A.; Delaux, P.-M.; Quint, M.; Theißen, G.; Hagemann, M.; Harholt, J.; Dunand, C.; Zachgo, S.; Langdale, J.; Maumus, F.; Van Der Straeten, D.; Gould, S. B.; Rensing, S. A. The Chara Genome: Secondary Complexity and Implications for Plant Terrestrialization Cell 174, 448-464.e24, (2018) DOI: ...
PubMed 26714610 Fernandez-Cuesta L, Sun R, Menon R, George J, Lorenz S, Meza-Zepeda LA, Peifer M, Plenker D, Heuckmann JM, Leenders F, Zander T, Dahmen I, Koker M, Schöttle J, Ullrich RT, Altmüller J, Becker C, Nürnberg P, Seidel H, Böhm D, Göke F, Ansén S, Russell PA, Wright GM, Wainer Z et al. (2015) ...
Ullrich, E., Heidinger, P., Soh, J., Villanova, L., Grabuschnig, S., Bachler, T., Hirschböck, E., Sánchez-Heredero, S., Ford, B., Sensen, M., Rosales Rodriguez, I., Schwendenwein, D., Neumeister, P., Zurl, C. J., Krause, R., Lorenz Khol, J. & Sensen, C. W., 20 Feb 2020, in : Journal of Biotechnology. 310, S. 80-88 9 S.. Publikation: Beitrag in einer Fachzeitschrift › Artikel ...
A Wayne County man was found guilty recently in magisterial court in Hawley of possessing a Capuchin monkey without a permit. John A. Poliandro of Lakeville purchased the monkey for just under $10,000 from Cheryls Primates, in Chillicothe, Mo., and the monkey was transported illegally into Pennsylvania, according to Wayne County Wildlife Conservation Officer James McCarthy.Separately, Cheryl Ullrich of Chillicothe, Mo., was charged with the illegal importation of game or wildlife and
Wieder, Thomas; Brenner, Ellen; Hahn, Matthias Stefan; Alkhaled, Mohammed; Schilbach, Karin; Essmann, Frank; Kneilling, Manfred; Grießinger, Christoph Michael; Ranta, Felicia; Ullrich, Susanne; Braungart, Kilian; Mehra, Tarun; Fehrenbacher, Birgit; Berdel, Julia; Niessner, Heike; Meier, Friedegund; Handgretinger, Rupert; Quintanilla-Martinez, Leticia; Fend, Falko; Pesic, Marina; Zender, Lars; Schaller, Martin; Schulze-Osthoff, Klaus; Braumüller, Heidi; Häring, Hans-Ulrich; Bauer, Jürgen; Röcken, Martin; Aßmann, Sonja Carmen Yamina (Nature Publishing Group, 2013) ...
Kopf A, Bicak M, Kottmann R, Schnetzer J, Kostadinov I, Lehmann K, Fernandez-Guerra A, Jeanthon C, Rahav E, Ullrich M, Wichels A, Gerdts G, Polymenakou P, Kotoulas G, Siam R, Abdallah R.Z, Sonnenschein E.C, Cariou T, OGara F, Jackson S, Orlic S, Steinke M, Busch J, Duarte B, Cacador I, Canning-Clode J, Bobrova O, Marteinsson V, Reynisson E, Loureiro C.M, Luna G.M, Quero G.M, Loscher C.R, Kremp A, DeLorenzo M.E, Ovreas L, Tolman J, LaRoche J, Penna A, Frischer M, Davis T, Katherine B, Meyer C.P, Ramos S, Magalhaes C, Jude-Lemeilleur F, Aguirre-Macedo M.L, Wang S, Poulton N, Jones S, Collin R, Fuhrman J.A, Conan P, Alonso C, Stambler N, Goodwin K, Yakimov M.M, Baltar F, Bodrossy L, Van De Kamp J, Frampton D.M.F, Ostrowski M, Van Ruth P, Malthouse P, Claus S, Deneudt K, Mortelmans J, Pitois S, Wallom D, Salter I, Costa R, Schroeder D.C, Kandil M.M, Amaral V, Biancalana F, Santana R, Pedrotti M.L, Yoshida T, Ogata H, Ingleton T, Munnik K, Rodriguez-Ezpeleta N, Berteaux-Lecellier V, Wecker P, Cancio ...
Gallery in Dusseldorf ARTISTS | JAN ALBERS, ANDREA BOWERS, ROBERT CRUMB, GEORGANNE DEEN, NICOLE EISENMAN, SABRINA FRITSCH, MANUEL GRAF, LEROY GRANNIS, GREGOR HILDEBRANDT, KATIE HOLTEN, MARKUS KARSTIESS, JAN KEMPENAERS, ROSILENE LUDUVICO, MARK MENDER, RUSS MEYER, TRACEY MOFFATT, REINHARD MUCHA, CADY NOLAND, MANFRED PERNICE, RUDOLF STEINER, JENS ULLRICH, JOCHEN WEBER, WENDY WHITE, STEFAN WISSEL
Anderson GL., Autier P., Beral V., Bosland MC., Fernández E., Haslam SZ., Kaufman DG., La Vecchia C., Molinolo AA., Newcomb PA., Parl FF., Peto J., Rosano G., Roy D., Stanczyk FZ., Thomas DB., Vatten L., Junghans T., Olin S., Shapiro S., Stafford RS., Jameson CW., Meyer JU., Baan R., Berthiller J., Cogliano VJ., Dresler C., El Ghissassi F., Franceschi S., Gonçalves MAG., Grosse Y., Guha N., Marron M., Mitchell J., Napalkov N., Secretan B., Straif K., Ullrich A., Egraz S., Kajo B., Lézère M., Lorenzen-Augros H ...
Boost Warp 4G by ZTE vs ZTE Axon Pro. Compare the specs and features of the Boost Warp 4G by ZTE and ZTE Axon Pro to see which is better.
Vi vet at sterke merkevarer og god kommunikasjon gjør en forskjell. Stor forskjell. Det kan endre oppfatninger, øke salget og bygge sterkere intern kultur. For å gjøre det du må innse sannheten og definere utfordringen. Vi legger stor vekt på planarbeidet og innsikt om publikum. Når vi er klar over hvilke tiltak som er nødvendige, har vi en bred verktøykasse å trekke fra og kan skape den optimale miksen av intervensjoner. Hele veien fra merkevarestrategi , visuell identitet, konseptualisering til kampanjer på nettet, på fjernsyn, sosiale medier og PR. ...
If it is as simple as just having the right conditions, it is reasonable to think that life should have evolved according to Darwinian principles many, many...
Idunn er Nordens ledende nettsted for fagtidsskrifter og open access-bøker. Vi tilbyr unike søkemuligheter i kvalitetssikret innhold på tvers av over 60 ulike tidsskrifter.
Idunn er Nordens ledende nettsted for fagtidsskrifter og open access-bøker. Vi tilbyr unike søkemuligheter i kvalitetssikret innhold på tvers av over 60 ulike tidsskrifter.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Collagen,_type_XX,_alpha_1&oldid=705418915" ...
Alpha 1 subunit of type VI collagen is the encoded protein. In terms of the diagnosis of Ullrich congenital muscular dystrophy ... It is associated with variants of type VI collagen, it is commonly associated with muscle weakness and respiratory problems, ... Bushby KM, Collins J, Hicks D (2014) Collagen type VI myopathies. Adv Exp Med Biol 802:185-199 "Congenital Muscular Dystrophy ... via ScienceDirect (Subscription may be required or content may be available in libraries.) "COL6A1 collagen type VI alpha 1 [ ...
Type VIII, X) Basement membrane (Type IV) Other (Type VI, VII, XIII) Elastins, in contrast to collagens, give elasticity to ... Each type of connective tissue in animals has a type of ECM: collagen fibers and bone mineral comprise the ECM of bone tissue; ... The collagen can be divided into several families according to the types of structure they form: Fibrillar (Type I, II, III, V ... Laminins bind other ECM components such as collagens and nidogens. There are many cell types that contribute to the development ...
"Binding of the proteoglycan decorin to collagen type VI". J. Biol. Chem. 267 (8): 5250-6. PMID 1544908. Bowe MA, Mendis DB, ... It has been reported that biglycan interacts more strongly with collagen type II than collagen type I. Biglycan has been ... Pogány G, Hernandez DJ, Vogel KG (August 1994). "The in vitro interaction of proteoglycans with type I collagen is modulated by ... "Interaction of biglycan with type I collagen". J. Biol. Chem. 270 (6): 2776-83. doi:10.1074/jbc.270.6.2776. PMID 7852349. ...
Found to have type I, III, VI, and XII collagen. See also[edit]. *Connective tissue in skeletal muscle ... The overall comprehensive organization of the perimysium collagen network, as well as its continuity and disparateness, however ...
Leitinger B, Kwan AP (2006). "The discoidin domain receptor DDR2 is a receptor for type X collagen". Matrix Biol. 25 (6): 355- ... protein tyrosine kinase collagen receptor activity. • protein tyrosine kinase activity. • ATP binding. • collagen binding. ... collagen-activated tyrosine kinase receptor signaling pathway. • ossification. • phosphorylation. • collagen fibril ... "Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen". J. Biol. Chem. 277 (21): ...
Bornstein P, Kyriakides TR, Yang Z, Armstrong LC, Birk DE (Dec 2000). "Thrombospondin 2 modulates collagen fibrillogenesis and ... "Entrez Gene: THBS2 thrombospondin 2". Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix ... Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of ... "Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen ...
Kawahara E, Oda Y, Katsuda S, Nakanishi I, Aoyama K, Tomita K (1991). "Microfilamentous type VI collagen in the hyalinized ... indicate that the hypertrophy of these ligaments may be linked to a fibrotic process associated with increased collagen VI, ...
... collagen type I, osteocalcin, osteonectin, and alkaline phosphatase. Collagen type I counts for 90% of the protein mass. The ... Fisher LW, Fedarko NS (2003). "Six genes expressed in bones and teeth encode the current members of the SIBLING family of ... "Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice". Proc. ... Different cell types may differ in their regulatory mechanisms of the OPN gene. OPN expression in bone predominantly occurs by ...
The cross helical fiber arrangement of the two dermal fibers types collagen and elastin, are responsible for the mechanical ... Mechanical properties of native and cross-linked type i collagen fibrils. Biophysical Journal, 94(6):2204-2211, March 2008. M R ... In Treatiseon collagen: 247-310. Gould, B. S. (Ed.). NY: Academic Press. Holbrook, K & Oldand, g F. A collagen and elastic ... These collagen fibers act as the structural support for the shape of the patagia, and provide the stiffness necessary to resist ...
Leitinger B, Kwan AP (2006). "The discoidin domain receptor DDR2 is a receptor for type X collagen". Matrix Biol. 25 (6): 355- ... "Phosphoproteomics of collagen receptor networks reveals SHP-2 phosphorylation downstream of wild-type DDR2 and its lung cancer ... "Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen". J. Biol. Chem. 277 (21): ... "Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen". J. Biol. Chem. 277 (21): ...
Collagen type IV alpha-3-binding protein, also known as ceramide transfer protein (CERT) or StAR-related lipid transfer protein ... "Entrez Gene: COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein". Merrill AH (Jul 2002). "De novo ... that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, ... PH domain of wild-type CERT has been found to recognize specifically PI4P and therefore CERT targets the Golgi apparatus or the ...
Cairns JA, Walls AF (1997). "Mast cell tryptase stimulates the synthesis of type I collagen in human lung fibroblasts". J. Clin ... 1996). "The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is ... 1997). "Effect of recombinant human IL-4 on tryptase, chymase, and Fc epsilon receptor type I expression in recombinant human ... 274 (6): 3355-62. doi:10.1074/jbc.274.6.3355. PMID 9920877. "Entrez Gene: TPSAB1 tryptase alpha/beta 1". Sommerhoff CP, Bode W ...
Burg MA, Tillet E, Timpl R, Stallcup WB (1996). "Binding of the NG2 proteoglycan to type VI collagen and other extracellular ... In contrast, when these same cells use either α9β1 or αvβ6 integrins to adhere to the same third FN type III repeat, cell ... 1994). "The integrin alpha 9 beta 1 mediates cell attachment to a non-RGD site in the third fibronectin type III repeat of ... This results in a multitude of TN-C subunits differing in the number and identity of fibronectin type III domain repeats. ...
Glycoprotein VI is one of the immunoglobulin superfamily type I transmembrane glycoproteins. It is an important collagen ... This is a receptor for collagen type I and IV. It consists of two subunits (α2 and β1). The α2 subunit includes a domain ... integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. (United States) 276 (31): 29368-74. DOI: ... and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin ...
This involved a mutation of the protein collagen, type X, alpha 1, encoded by the COL10A1 gene. In humans a similar mutation ( ... December 2000). "Abnormal growth plate function in pigs carrying a dominant mutation in type X collagen". Mamm. Genome. 11 (12 ... Savarirayan, Ravi (4 July 2019). "C-Type Natriuretic Peptide Analogue Therapy in Children with Achondroplasia". New England ... This protein contributes to the production of collagen and other structural components in tissues and bones. When the FGFR3 ...
Other (Type VI, VII, XIII). ElastinEdit. Elastins, in contrast to collagens, give elasticity to tissues, allowing them to ... Each type of connective tissue in animals has a type of ECM: collagen fibers and bone mineral comprise the ECM of bone tissue; ... CollagenEdit. Collagens are the most abundant protein in the ECM. In fact, collagen is the most abundant protein in the human ... The collagen can be divided into several families according to the types of structure they form: *Fibrillar (Type I, II, III, V ...
... chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen". J ... Matsumoto S, Katoh M, Saito S (1998). "Identification of soluble type of membrane-type matrix metalloproteinase-3 formed by ... MT-MMPs form a unique membrane-type subclass in the MMP family". J Biol Chem. 270 (39): 23013-20. doi:10.1074/jbc.270.39.23013 ... Mattei MG, Roeckel N, Olsen BR, Apte SS (1997). "Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, ...
It has been proposed that miR-675 may modulate collagen type II levels via an unknown target molecule, and there is potential ... Dudek KA, Lafont JE, Martinez-Sanchez A, Murphy CL (August 2010). "Type II collagen expression is regulated by tissue-specific ... 40 (8): 971-6. doi:10.1038/ng.168. PMID 18587395. S2CID 5204748. Page for mir-675 microRNA precursor family at Rfam v t e. ... 7 (6): e38648. Bibcode:2012PLoSO...738648X. doi:10.1371/journal.pone.0038648. PMC 3377716. PMID 22719913. Lu TX, Sherrill JD, ...
Genetic linkage of the inheritance of the disease points to the region of chromosome 3 near the collagen, type VII, alpha 1 ... a glycine substitution mutation in the type VII collagen gene". American Family Physician. 106 (6): 1340-2. doi:10.1111/1523- ... ISBN 978-0-7216-2921-6. Christiano AM, Bart BJ, Epstein EH Jr, Uitto J (1996). "Genetic basis of Bart's syndrome: ...
"Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner". Stem Cell Research & ... such as the collagen is produced by fibroblasts, leading to the formation of a permanent fibrotic scar. In response to injury, ... including collagen and glycosaminoglycans. The process is initiated when immune cells such as macrophages release soluble ... 135 (11): 2873-6. doi:10.1038/jid.2015.252. PMC 4640976. PMID 26134944. Leask A, Abraham DJ (2004). "TGF-beta signaling and the ...
Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ... integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. 276 (31): 29368-74. doi:10.1074/jbc. ... They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. ... Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells. The DX5 monoclonal ...
An in vitro study with native collagen demonstrated that fibronectin binds to type III collagen rather than other types. Plasma ... Fetal fibronectin Fibronectin type I domain Fibronectin type II domain Fibronectin type III domain Monobody, an engineered ... type I and type II are stabilized by intra-chain disulfide bonds, while type III modules do not contain any disulfide bonds. ... Lapiere JC, Chen JD, Iwasaki T, Hu L, Uitto J, Woodley DT (November 1994). "Type VII collagen specifically binds fibronectin ...
Horton, WA, Campbell, D, Machado, MA & Chou, J; Campbell; Machado; Chou (1989). "Type II collagen screening in the human ... Gajko-Galicka, A (2002). "Mutations in type I collagen genes resulting in osteogenesis imperfecta in humans". Acta biochimica ... "Ehlers-Danlos syndrome and type III collagen abnormalities: a variable clinical spectrum". Clinical Genetics 53 (6): 440-446. ... Type 2: brusk (hovedkomponent). Sykdommer[rediger , rediger kilde]. Ett tusen mutasjoner er blitt identifisert i tolv av mer ...
2007). "Human collagen Krox up-regulates type I collagen expression in normal and scleroderma fibroblasts through interaction ... Galera P, Musso M, Ducy P, Karsenty G (Oct 1994). "c-Krox, a transcriptional regulator of type I collagen gene expression, is ... response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen ... doi:10.1016/S0945-053X(01)00167-6. PMID 11691585. Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial ...
The menisci contain 70% type I collagen.[6] The larger semilunar medial meniscus is attached more firmly than the loosely fixed ... If the meniscus is removed, the patient will be in rehab for about four to six weeks. If a repair is conducted, then the ... In 1978, Shrive et al. reported that the collagen fibers of the menisci are oriented in a circumferential pattern.[6] When a ... This type of rehabilitation focuses on maintenance of full range of motion and functional progression without aggravating the ...
Type III collagen. liver, bone marrow, and lymphatic organs USES[edit]. Connective tissue has a wide variety of functions that ... Type I collagen is present in many forms of connective tissue, and makes up about 25% of the total protein content of the ... Type I Collagen". Journal of Biological Chemistry. 277 (6): 4223-31. doi:10.1074/jbc.M110709200. PMID 11704682.. ... Types of fibers: Tissue. Purpose. Components. Location Collagenous fibers. Bind bones and other tissues to each other. Alpha ...
"Verification of simple hydration/dehydration methods to characterize multiple water compartments on Tendon Type 1 Collagen". ... Like quartz crystal, collagen in the ground substance and the more stable connective tissues (fascia, tendons, bones, etc.). ... Major ordering energy structures in the body are created by the ground substance, such as collagen, which not only conducts ... This is a structured water that provides stability for metabolic functioning, and related to collagen as well, the major ...
Leitinger B, Kwan AP (2007). „The discoidin domain receptor DDR2 is a receptor for type X collagen.". Matrix Biol. 25 (6): 355- ... B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, ... B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, ... Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen". J. Biol. Chem. United ...
Several types of catenins work with N-cadherins to play an important role in learning and memory (For full article, see ... Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR (October 2011). "A role for collagen XXIII in cancer cell ... For instance, higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened ... levels of collagen helped facilitate adhesions and anchorage-independent cell growth and provided evidence of collagen XXIII's ...
Atrophic acne scars have lost collagen from the healing response and are the most common type of acne scar (account for ... in certain women due to similar efficacy at six months and a lack of associated antibiotic resistance.[110] Progesterone-only ... doi:10.1016/S0140-6736(16)31678-6. PMC 5055577. PMID 27733282.. *^ a b c d e f g h i j k l m n o p q r s t u v Aslam I, ... microspheres with collagen; human and bovine collagen derivatives, and fat harvested from the person's own body (autologous fat ...
collagen-containing extracellular matrix. Biological process. • positive regulation of inflammatory response. • positive ... positive regulation of type IV hypersensitivity. • positive regulation of transcription, DNA-templated. • humoral immune ... 4 (6): 457-61. doi:10.1038/ncb802. PMID 12021773. S2CID 11575790.. *. Jovine L, Qi H, Williams Z, Litscher ES, Wassarman PM ( ... 100 (26): 15631-6. Bibcode:2003PNAS..10015631D. doi:10.1073/pnas.2635507100. PMC 307619. PMID 14673092.. ...
List of human cell types derived from the germ layers. References[edit]. *^ .mw-parser-output cite.citation{font-style:inherit ... COL2A1 collagen disease. *Achondrogenesis *type 2. *Hypochondrogenesis. SLC26A2 sulfation defect. *Achondrogenesis *type 1B ...
The dissolution of collagen depends on time, temperature and environmental pH.[8] At high temperatures, the rate of collagen ... The study of diagenesis in rocks is used to understand the geologic history they have undergone and the nature and type of ... The composite nature of bone, comprising one-third organic (mainly protein collagen) and two thirds mineral (calcium phosphate ... The hydrolytic activity plays a key role in the mineral phase transformations that exposes the collagen to accelerated chemical ...
Type I collagen is present in many forms of connective tissue, and makes up about 25% of the total protein content of the ... Type I Collagen". Journal of Biological Chemistry. 277 (6): 4223-31. doi:10.1074/jbc.M110709200. PMID 11704682.. ... TypesEdit. Connective tissue can be broadly subdivided into connective tissue proper, and special connective tissue.[5][6] ... groups of adipose cells are kept together by collagen fibers and collagen sheets in order to keep fat tissue under compression ...
Diagnostic plates: intended to determine the type of color vision defect (protanopia or deuteranopia) and the severity of it. ... Corneal collagen cross-linking. Iris, ciliary body,. sclera, and anterior chamber. *Glaucoma surgery: Trabeculectomy ...
10% of all dislocations are anterior and this is broken down into superior and inferior types.[32] Superior dislocations ... syndrome is genetically inherited disorder that is thought to affect the encoding of the connective tissue protein's collagen ... the most common type of shoulder dislocation (96-98% of the time) occurs when the arm is in external rotation and abduction ( ... 31 (6): 725-732. doi:10.1016/j.ultrasmedbio.2005.03.002.. *^ Gaillard, Frank. "Developmental dysplasia of the hip , Radiology ...
Both types of plants occur in tropical areas, but only C3 plants occur naturally in colder areas. 12C and 13C occur in a ratio ... Six of these individuals had dental modifications similar to those carried out by peoples inhabiting tropical areas known to be ... Nitrogen isotopes in bone collagen are ultimately derived from dietary protein, while carbon can be contributed by protein, ... This references the variety of types of labor (e.g., domestic vs. carrying heavy loads) labor that enslaved individuals were ...
Possibly important to basement membrane architecture and tissue development, as a needed catalyst to make collagen IV.[37] ... ISBN 1-57259-931-6.. *^ a b Ultratrace minerals. Authors: Nielsen, Forrest H. USDA, ARS Source: Modern nutrition in health and ... 8 (6): 277-81. doi:10.1177/0115426593008006277. PMID 8302261.. *^ Momcilović, B. (September 1999). "A case report of acute ... ISBN 978-3-540-71840-6.. *^ Gadd, G. M (2017). "The Geomycology of Elemental Cycling and Transformations in the Environment" ( ...
Data also proposed a decrease in weight gain as a result of increased consumption lessens the risk of developing diabetes type ... Foundation for strong healthy bones and teeth - majority of the calcium consumed as a child is deposited onto collagen bone ... Vitamin A ensures sufficient collagen is produced to build strong healthy bones and other connecting tissues (Deen & Hark, 2007 ... A 2007 study by Boeing et al., explored common chronic lifestyle diseases including diabetes type 2 mellitus, obesity, ...
Based on this, eight types of secondary structure are assigned. The 310 helix, α helix and π helix have symbols G, H and I and ... Two types of beta sheet structures exist; a beta bridge has symbol B while longer sets of hydrogen bonds and beta bulges have ... is at least 70°), and a blank (or space) is used if no other rule applies, referring to loops.[3] These eight types are usually ...
Type. Appearance (micrograph). Appearance (illustration). Approx. %. in adults. See also:. Blood values. Diameter (μm)[7]. Main ... It rises in response to allergies, parasitic infections, collagen diseases, and disease of the spleen and central nervous ... This type of white blood cell decreased is usually the neutrophil. In this case the decrease may be called neutropenia or ... Types of white blood cells can be classified in standard ways. Two pairs of broadest categories classify them either by ...
There are two types of alveolar epithelial cells - Type 1 pneumocytes represent 90% of the cell surface area, and are easily ... Prior to 9/11, 3% of firefighters had below-normal lung function, one year after 9/11 nearly 19% did, and six years later it ... Mice that survive this initial onslaught go on to demonstrate an increase in lung collagen content, and decreased lung ... Type 2 pneumocytes are more resistant to damage, which is important as these cells produce surfactant, transport ions and ...
... of which is collagen type 1 and the remaining 10% ground substance, which includes dentine-specific proteins), and 10% water ( ... TypesEdit. There are three types of dentin, primary, secondary and tertiary.[13][14] Secondary dentin is a layer of dentin ... It is of two types, either reactionary, where dentin is formed from a pre-existing odontoblast, or reparative, where newly ... It is unmineralized and consists of collagen, glycoproteins and proteoglycans. It is similar to osteoid in bone and is thickest ...
Types[edit]. General[edit]. Irwin Fridovich and Joe McCord at Duke University discovered the enzymatic activity of superoxide ... The ligands of the copper and zinc are six histidine and one aspartate side-chains; one histidine is bound between the two ... insights into heparin and collagen binding". J. Mol. Biol. 388 (2): 310-26. doi:10.1016/j.jmb.2009.03.026. PMID 19289127.. ... Fe and Mn types (which bind either iron or manganese), and the Ni type (which binds nickel). ...
Six-fingered dwarfism' ('digital integer deficiency') was an alternative designation used for this condition when it was being ... organelles which are present in many cellular types throughout the human body. The cilia defects adversely affect "numerous ... is a rare genetic disorder of the skeletal dysplasia type. ... COL2A1 collagen disease. *Achondrogenesis *type 2. * ... 24 (3): 283-6. doi:10.1038/73508. PMID 10700184.. *^ Badano, Jose L.; Norimasa Mitsuma; Phil L. Beales; Nicholas Katsanis ( ...
... six to eight months were required, possibly due to the pre-loading of this group with a 70 mg/day supplement for six weeks ... as healthy collagen replaces the defective collagen with vitamin C repletion. Treatment can be orally or by intramuscular or ... Yamada H, Yamada K, Waki M, Umegaki K (October 2004). "Lymphocyte and plasma vitamin C levels in type 2 diabetic patients with ... including wound healing and collagen synthesis. In humans, vitamin C deficiency leads to impaired collagen synthesis, ...
Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... Work at the Institute for Cell Biology, University of Bonn, showed that a certain type of autophagy, i.e., chaperone-assisted ... the accumulation of damaged organelles in collagen VI deficient muscle fibres was prevented and cellular homeostasis was ... "Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles". ...
Two types of PDGFRs have been identified: alpha-type and beta-type PDGFRs.[8] The alpha type binds to PDGF-AA, PDGF-BB and PDGF ... The addition of PDGF at specific time‐points has been shown to stabilise vasculature in collagen‐glycosaminoglycan scaffolds.[ ... Types and classification[edit]. There are five different isoforms of PDGF that activate cellular response through two different ... The receptor for PDGF, PDGFR is classified as a receptor tyrosine kinase (RTK), a type of cell surface receptor. ...
The three main types of hyaluronidases are two classes of eukaryotic endoglycosidase hydrolases and a prokaryotic lyase-type of ... Csóka AB, Scherer SW, Stern R (September 1999). "Expression analysis of six paralogous human hyaluronidase genes clustered on ... "Testicular hyaluronidase induces tubular structures of endothelial cells grown in three-dimensional collagen gel through a CD44 ... "The six hyaluronidase-like genes in the human and mouse genomes". Matrix Biology. 20 (8): 499-508. doi:10.1016/S0945-053X(01) ...
TNF can bind two receptors, TNFR1 (TNF receptor type 1; CD120a; p55/60) and TNFR2 (TNF receptor type 2; CD120b; p75/80). TNFR1 ... Tumor necrosis factor (TNF) alpha increases collagen accuulation and proliferation in intestinal myofibrobasts via TNF Receptor ... TNF is primarily produced as a 233-amino acid-long type II transmembrane protein arranged in stable homotrimers.[24][25] From ... TNF was thought to be produced primarily by macrophages,[36] but it is produced also by a broad variety of cell types including ...
There are six human genes associated with it:[2] *COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6 ... Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C- ... Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen".[citation needed] Collagen IV ... type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 ...
... that is caused by a mutation in one of the three genes coding for type VI collagen.[2] These include COL6A1, COL6A2, and COL6A3 ... Okada M et al (2007) Primary collagen VI deficiency is the second most common congenital muscular dystrophy in Japan. Neurolog ... "Collagen VI related muscle disorders" (PDF). J. Med. Genet. 42 (9): 673-85. doi:10.1136/jmg.2002.002311. PMC 1736127 . PMID ...
Saad, Mohamed (Oct 1994). Low resolution structure and packing investigations of collagen crystalline domains in tendon using ... Six minerals have been classified as "asbestos" including chrysotile of the serpentine class and those belonging to the ... Kraft and sulfite (also called sulphite) refer to the type of pulping process used to remove the lignin bonding the original ... Instances are collagen[3] family of proteins, tendon, muscle proteins like actin, cell proteins like microtubules and many ...
After CGPD resolves, the skin may return to normal without scarring or may have small atrophic depressions with collagen loss, ... Gianotti-type perioral dermatitis or Facial Afro-Caribbean childhood eruption Specialty. Dermatology. ...
Possibly collagen and/or citrullinated self proteins. Chronic arthritis, inflammation, destruction of articular cartilage and ... Type V hypersensitivity. References[edit]. *^ a b c d e f g Kumar, Vinay; Abbas, Abul K.; Aster, Jon C. (2012-05-01). Robbins ... Type 4 hypersensitivity is often called delayed type hypersensitivity as the reaction takes several days to develop. Unlike the ... Diabetes mellitus type 1[1]. Pancreatic beta cell proteins (possibly insulin, glutamate decarboxylase). Insulitis, beta cell ...
Collagen cross-linking by applying riboflavin topically then shining UV light is a method to slow progression of corneal ... One such organism is Micrococcus luteus (American Type Culture Collection strain number ATCC 49442), which develops a yellow ... doi:10.1186/s40662-015-0030-6. PMC 4675057 . PMID 26665102.. *^ Yonemura, S; Doane, S; Keil, S; Goodrich, R; Pidcoke, H; ... "Collagen cross-linking: when and how? A review of the state of the art of the technique and new perspectives". Eye and vision ...
Platelet activation (through agonists such as thrombin, Type II collagen and ADP) results in "membrane flipping" where the ... In human, P-selectin has nine repeats while E-selectin contains six and L-selectin has only two. P-selectin is anchored in ... The extracellular region of P-selectin is composed of three different domains like other selectin types; a C-type lectin-like ... a type of glycosaminoglycan (GAG). Its activity in tumor metastasis has been probed by the addition of heparin that functions ...
ANA type. Target antigen. Sensitivity (%) SLE. Drug-induced LE. Diffuse systemic sclerosis. Limited systemic scleroderma. ... There are six known antigens, which are all associated with the centromere; CENP-A to CENP-F. CENP-A is a 17kDa histone H3-like ... collagen IV, fibronectin and laminin. Binding to these antigens within the kidney could cause inflammation and complement ... a b c d e f g h i j k l m n o p q r s t u v w x y z aa ab ac ad ae af ag ah ai aj ak al am an ao ap Table 6-2 in: Elizabeth D ...
Collagen type VI myopathies.. Bushby KM1, Collins J, Hicks D.. Author information. 1. Institute of Genetic Medicine, Newcastle ... Mutations in each of the three collagen VI genes COL6A1, COL6A2 and COL6A3 cause two main types of muscle disorders: Ullrich ... Collagen VI is an important component of the extracellular matrix which forms a microfibrillar network that is found in close ... Collagen VI is also found in the interstitial space of many tissues including muscle, tendon, skin, cartilage, and ...
VI), α2(VI), and α3(VI) collagen chains. The sizes of the α1(VI), α2(VI), and α3(VI) collagen mRNAs are 4.2, 3.5, and 8-10 kb, ... The α1(VI) and α2(VI) collagen chains comigrated at 140 kDa, whereas the α3(VI) collagen chains migrated at 260-300 kDa. ... VI), α2(VI), and α3(VI) collagen chains, respectively. Hybridization and washing were performed under stringent conditions, and ... Ullrich scleroatonic muscular dystrophy is caused by recessive mutations in collagen type VI. Olga Camacho Vanegas, Enrico ...
collagen trimer, extracellular exosome, extracellular matrix, extracellular space, extracellular vesicle, proteinaceous ... Collagen, type VI, alpha 3Imported. ,p>Information which has been imported from another database using automatic procedures.,/p ... tr,E9PWQ3,E9PWQ3_MOUSE Collagen, type VI, alpha 3 OS=Mus musculus GN=Col6a3 PE=1 SV=2 ... R-MMU-1442490. Collagen degradation. R-MMU-1650814. Collagen biosynthesis and modifying enzymes. R-MMU-186797. Signaling by ...
"Entrez Gene: COL6A1 collagen, type VI, alpha 1". Bertini E, Pepe G (2002). "Collagen type VI and related disorders: Bethlem ... The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI ... 1989). "Sequence analysis of alpha 1(VI) and alpha 2(VI) chains of human type VI collagen reveals internal triplication of ... "Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen". J. Biol. Chem. 272 (42): 26522-9 ...
This protein is an alpha chain of type VI collagen that aids in microfibril formation. As part of type VI collagen, this ... type VI, alpha 3". Lamandé SR, Mörgelin M, Adams NE, Selan C, Allen JM (Jun 2006). "The C5 domain of the collagen VI alpha3(VI ... "Structure and multiple conformations of the kunitz-type domain from human type VI collagen alpha3(VI) chain in solution". ... chain in collagen VI assembly. Expression of an alpha3(VI) chain lacking N-terminal modules N10-N7 restores collagen VI ...
The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers. ... A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. ... VI); Intima Collagen; Procollagen Type VI; Type VI (Intima) Collagen; Type VI Collagen; Type VI Procollagen; Collagen Type VI, ... Collagen Type VI, alpha1 Chain; Collagen Type VI, alpha1 Subunit; Collagen Type VI, alpha2 Subunit; Collagen Type VI, alpha3 ...
We therefore examined the effects of type VI collagen deficiency on bone. 3D-μCT analysis revealed that type VI collagen ... Type VI collagen is one of bone matrix proteins but its function is not known. ... Bone consists of type I collagen as a major protein with minor various matrix proteins. ... Furthermore, type VI collagen deficiency disorganized collagen arrangement. These data indicate that type VI collagen ...
... verified that complexes of type VI collagen and decorin bound type I collagen and that the affinity of collagen type VI to type ... formation but that it also can act as an intermediary between type I and type VI collagen and that these two types of collagen ... Differential interactions of decorin and decorin mutants with type I and type VI collagens.. Nareyeck G1, Seidler DG, Troyer D ... In contrast, the affinities of these mutants to type VI collagen were 10 times higher than the affinity of wild-type decorin (K ...
... of the collagen type VI genes (COL6A1, COL6A2, COL6A3) that affect the N- terminal domains [34-36]. Collagen type VI assemblies ... Type VI collagen interacts with extracellular matrix constituents [29,30] in several connective tissues [31-33]. Collagen type ... Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen. J Biol Chem. 1997; 272:26522-9. [ ... Unlike the more abundant type I collagen [3], type VI collagen gives rise to cross-banded aggregates that are characterized by ...
Since collagen type I and VI are also found in the granulation/scar tissue of lesions with advanced wound age, the ... A total of 74 human skin wounds were investigated and collagen types I and VI were localized in the wound area by ... A positive staining for collagen type VI represents a post-infliction time of 3 days or more. The almost constant appearance of ... Immunohistochemical localization of collagen types I and VI in human skin wounds. In: International Journal of Legal Medicine, ...
Purified Anti-Type VI Collagen antibody for use in ELISA, immunohistochemistry / immunocytochemistry, electron microscopy, and ... Reacts with conformational determinants on type VI collagen Source. Pooled antisera from goats hyperimmunized with type VI ... Collagen type VI expression during cardiac development and in human fetuses with trisomy 21. Anat Rec A Discov Mol Cell Evol ... 0109-01; left) and Goat Anti-Type VI Collagen-UNLB (SB Cat. No. 1360-01; right) followed by Swine Anti-Goat IgG(H+L), Human/Rat ...
IPR008160 Collagen. IPR001442 Collagen_IV_NC. IPR036954 Collagen_IV_NC_sf. IPR016187 CTDL_fold. ... IPR008160 Collagen. IPR001442 Collagen_IV_NC. IPR036954 Collagen_IV_NC_sf. IPR016187 CTDL_fold. ... Collagen type IV alpha 6 chainImported. ,p>Information which has been imported from another database using automatic procedures ... tr,A0A2K5E8P9,A0A2K5E8P9_AOTNA Collagen type IV alpha 6 chain OS=Aotus nancymaae OX=37293 GN=COL4A6 PE=4 SV=1 ...
Information for clinical testing of Collagen Type VI-Related Disorders:. We test for mutations in three genes related to ... Your physician will receive results by e-mail and mail in approximately six (6) to eight (8) weeks. ...
A total of 30 newborn to 6 year-old lumbar ovine... ... Aggrecan, versican and type VI collagen are components of ... McDevitt CA, Marcelino J, Tucker L (1991) Interaction of intact type VI collagen with hyaluronan. FEBS Lett 294:167-170PubMed ... Carvalho HF, Felisbino SL, Keene DR, Vogel KG (2006) Identification, content, and distribution of type VI collagen in bovine ... Kielty CM, Whittaker SP, Grant ME, Shuttleworth CA (1991) Type VI collagen forms a structural association with hyaluronan in ...
All skin types - Targeted treatments - FACIAL CARE. Grand choix All skin types, vernis a ongle et vernis semi permanent, ... Prepare the collagen sheet, cutting holes for the mouth, nose and eyes. Apply the sheet to the face. Dampen it with two sponges ... Ideal for dehydrated, dry and sensitive skin, these sheets comprising only native collagen fibres provide intense hydration*. ... INGREDIENTS : COLLAGEN, HYDROGENATED POLYISOBUTENE, PPG-15 STEARYL ETHER, PEG-40 SORBITAN PEROLEATE, BHT. ...
Collagen type VI network, Collagen type IX [extracellular region] (Mus musculus) * Integrin alpha10beta1 [plasma membrane] (Mus ... Collagen tupe VI network, Collagen type IX:Integrin alpha10beta1 [plasma membrane] (Mus musculus) ...
The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI ... The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). Mutations in the genes that ... Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. Collagen VI is ... code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy. ...
... type VI collagen and, as we previously described, type I and IV collagen was significantly stronger on protein level as on ... Type VI collagen is composed of a 200 kd subunit and two 140 kd subunits. EMBO J. 1986;5:2815-2819. [PubMed] ... All of the astrocyte cell lines expressed elastin and the α1, -2, and -3 chains of collagen type VI (Fig. 2A) . Treatment with ... Effect of TGF-β2 on elastin and type VI collagen. (A) Reverse transcription-PCR analysis of elastin and Col6α2 and -α3 ...
Chondrogenic hMSCs develop a thin pericellular matrix (PCM), consisting of type VI collagen (ColVI) and proteoglycans such as ... Modulating the pericellular matrix through silencing type VI collagen and decorin. ...
Anti-Collagen Type VI, human. Description. Mouse monoclonal Antibody to human Collagen type VI. ...
Collagen types VI, IX bind integrin alpha10beta1 (Homo sapiens) * Collagen tupe VI network, Collagen type IX:Integrin ... Collagen type IX:Integrin alpha10beta1 [plasma membrane] (Bos taurus) Collagen tupe VI network, Collagen type IX:Integrin ... Collagen type IX:Integrin alpha10beta1 [plasma membrane] (Danio rerio) Collagen tupe VI network, Collagen type IX:Integrin ... Collagen type IX:Integrin alpha10beta1 [plasma membrane] (Rattus norvegicus) Collagen tupe VI network, Collagen type IX: ...
... this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the ... Like the other members of the type IV collagen gene family, ... This gene encodes one of the six subunits of type IV collagen, ... Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked ... this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the ...
Tamm, Ernst R., Jungkunz, W., Marsch, W. C. und Lütjen-Drecoll, E. (1992) Increase in types IV and VI collagen in cherry ... Antibodies against collagen types III, IV and VI and laminin were used. Hyaluronic acid was visualized using the hyaluronic ... Antibodies against collagen types III, IV and VI and laminin were used. Hyaluronic acid .... ... Immunogold staining revealed that type VI collagen was localized to microfibrils 5-6 nm thick and to the broad-banded ...
VI) and alpha 2(VI) chains of human type VI collagen reveals internal triplication of globular domains similar to the A domains ... Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen. J Biol Chem, 272(42), 26522-26529 ... Three novel collagen VI chains, alpha4(VI), alpha5(VI), and alpha6(VI). J Biol Chem, 283(29), 20170-20180. doi: 10.1074/jbc. ... chain in collagen VI assembly. Expression of an alpha3(VI) chain lacking N-terminal modules N10-N7 restores collagen VI ...
Collagen chain trimerization (Mus musculus) * Association of procollagen type VI (Mus musculus) * Collagen type VI [endoplasmic ... Collagen type VI [endoplasmic reticulum lumen] (Mus musculus) * Collagen type VI dimer [endoplasmic reticulum lumen] (Mus ... Collagen type VI tetramer [endoplasmic reticulum lumen] (Mus musculus) * Collagen type VI dimer [endoplasmic reticulum lumen] ( ... Collagen type VI dimer [endoplasmic reticulum lumen] (Mus musculus) * Collagen type VI [endoplasmic reticulum lumen] (Mus ...
And VI, Collagen types I, Decidua, Endometrium, Female reproductive tract, III, Implantation, IV, Lysophosphatidic acid ... Altered spatiotemporal expression of collagen types I, III, IV, and VI in Lpar3-deficient peri-implantation mouse uterus. ... this study aimed to characterize the expression of four main uterine collagen types: fibril-forming collagen (COL) I and COL ... HomeResearchResearch ExplorerPublicationsAltered spatiotemporal expression of collagen types I, III, ... ...
title = "Overexpression of type VI collagen in neoplastic lung tissues",. abstract = "Type VI collagen (COL6), an extracellular ... Overexpression of type VI collagen in neoplastic lung tissues. Larry Voiles, David E. Lewis, Ling Han, Ivan P. Lupov, Tsang ... Overexpression of type VI collagen in neoplastic lung tissues. / Voiles, Larry; Lewis, David E.; Han, Ling; Lupov, Ivan P.; Lin ... Overexpression of type VI collagen in neoplastic lung tissues. In: Oncology reports. 2014 ; Vol. 32, No. 5. pp. 1897-1904. ...
Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens) * Collagen types III, IV ... Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] Stable Identifier ... Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Bos taurus) ... Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Canis familiaris) ...
Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts. ... Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts. ... In summary, mechanical restriction by type I collagen opposes the overall tumor-promoting effects of CAF, thus providing a ... Therapeutic targeting of tumor-promoting CAF mediators while preserving type I collagen may convert CAF from tumor promoting to ...
Recombinant Collagen Type VI Alpha 1 (COL6a1), Cat#RPU40904. Write a Review Write a Review. × ... Recombinant Collagen Type VI Alpha 1 (COL6a1), Cat#RPU40904. Rating Required Select Rating. 1 star (worst). 2 stars. 3 stars ( ... Product/Service Type: ELISA Kits. *Immunity, 50(2): 446-461.e9. (2019). PMID: 30709742. Title: Microbiota Sensing by Mincle-Syk ... Product/Service Type: Custom Gene Synthesis Service. *Nature, 577: 689-694. (2020). PMID: 31942068. Title: VEGF-C-driven ...
  • To test whether decorin can act as a bridging molecule between these collagens, the binding properties of wild-type decorin, two full-length decorin species with single amino acid substitutions (DCN E180K, DCN E180Q), which previously showed reduced binding to collagen type I fibrils, and a truncated form of decorin (DCN Q153) to the these collagens were investigated. (nih.gov)
  • We selected most pathways col6a1 participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Axon guidance, Collagen biosynthesis and modifying enzymes, which may be useful for your reference. (creativebiomart.net)
  • Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. (news-medical.net)
  • Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen respectively. (news-medical.net)
  • β1 integrin (also known as CD29) is a member of the subfamily of collagen-binding integrins (including α1β1, α2β1, α10β1 and α11β1) which bind to the triple-helical GFOGER sequence on collagen fibrils. (nature.com)
  • Thus, antibodies to these domains should stain fibroblasts synthesizing type I collagen but not extracellular collagen fibrils which could mask the signal from the cells. (jci.org)
  • Collagen fibrils are collagen molecules packed into an organized overlapping bundle. (newworldencyclopedia.org)
  • Collagen fibers are bundles of fibrils. (newworldencyclopedia.org)
  • Formation of Native-Type Collagen Fibrils by Cultured Fibroblasts. (nii.ac.jp)
  • Collagen fibrils with periodic banding pattern were detected in the extracellular spaces, however, the banding images are not clear enough to identify the polarity of the fibrils or to asign the composition of constituting alpha chains. (nii.ac.jp)
  • 4. Fibrils were formed from the extracted collagens in vitro, showing the native-type banding pattern. (nii.ac.jp)
  • 5. Computer programs were developed to analyse, and simulate the banding patterns of collagen fibrils and SLS by the primary structure. (nii.ac.jp)
  • A fibril-associated collagen usually found crosslinked to the surface of COLLAGEN TYPE II fibrils. (bioportfolio.com)
  • 12 13 Thus, the scenario was suggested that LDL bound to collagen, became oxidized, and would afterwards be taken up by macrophages gliding along collagen fibrils. (ahajournals.org)
  • Contains clinically researched levels of hair growth vitamins such as Biotin, Vitamin B5, and Collagen Peptides for maximum hair regrowth and health. (amazon.com)
  • Enjoy a Collagen Peptides Green Smoothie-And Win a Vitamix! (marksdailyapple.com)
  • Boosted by Primal Kitchen® Collagen Peptides, this green smoothie offers ingredients that support healthy hair, skin and nails and connective tissue. (marksdailyapple.com)
  • Hydrolysed collagen is manufactured via a specific hydrolysis process, where enzymes "cut" the triple helix molecule into smaller pieces, i.e. short-chain peptides. (nutraingredients.com)
  • This is why hydrolysed collagen is also known as collagen peptides, or denatured type II collagen. (nutraingredients.com)
  • Through the establishment of a chimeric HLA-DR/I-E transgene, we have examined the function of the rheumatoid arthritis (RA) susceptibility allele HLA-DR4 (DRB1*0401) in presenting antigenic peptides derived from the model Ag, type II collagen (CII), and in mediating an autoimmune response. (jimmunol.org)
  • This shared epitope has been proposed to be a mechanism for selection of pathogenic peptides ( 7 ), a mechanism for selection of pathogenic T cells ( 8 ), or a source of a peptide that, in turn, affects the function of an HLA-DQ molecule that actually mediates the autoimmune response ( 5 , 6 ). (jimmunol.org)
  • Bluebonnet's Beautiful Ally™ Collagen Powder is specially formulated with collagen peptides types I + III, key structural components for lustrous hair, firm skin and durable nails. (vitacost.com)
  • Collagen peptides help to replenish the nutrients lost over time, boosting collagen production while reducing its breakdown thereby enhancing the skin's hydration and natural elasticity while counteracting visible signs of aging. (vitacost.com)
  • Collagens are extracellular matrix proteins and have a triple-helical domain as their common structural element. (wikipedia.org)
  • The alpha 3 type VI chain has been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. (wikipedia.org)
  • Type A modules: interacting domains found in several non-fibrillar collagens and in other extracellular matrix proteins. (ebi.ac.uk)
  • This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. (wikipedia.org)
  • Collagen alpha-1(VI) chain is a protein that in humans is encoded by the COL6A1 gene. (wikipedia.org)
  • The protein encoded by this gene is the alpha 1 subunit of type VI collagen (alpha1(VI) chain). (wikipedia.org)
  • Collagen alpha-3(VI) chain is a protein that in humans is encoded by the COL6A3 gene. (wikipedia.org)
  • This gene encodes the alpha 3 chain, one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. (wikipedia.org)
  • The human type VI collagen gene. (wikipedia.org)
  • This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. (urogene.org)
  • Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. (urogene.org)
  • Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. (urogene.org)
  • The Blueprint Genetics Collagen Type VI-Related Disorders Panel is a six gene test for genetic diagnostics of patients with clinical suspicion of Bethlem myopathy or Ullrich congenital muscular dystrophy. (blueprintgenetics.com)
  • Recently, both dominant and recessive mutations in another collagen gene ( COL12A1 ) have been found in patients with both Ullrich and Bethlem phenotypes. (blueprintgenetics.com)
  • COL20A1 is a collagen gene. (wikipedia.org)
  • COL6A1 (Collagen Type VI Alpha 1 Chain) is a Protein Coding gene. (genecards.org)
  • defect in gene regulation or collagen processing? (uva.nl)
  • Collagen alpha-1(XVIII) chain is a protein that in humans is encoded by the COL18A1 gene . (wikipedia.org)
  • This gene encodes the alpha chain of type XVIII collagen. (wikipedia.org)
  • Collagen involves the harmonization of three polypeptide chains into the form of a triple helix. (newworldencyclopedia.org)
  • 6. The polypeptide fragment of claim 5 wherein said substrate is glass, synthetic resin or long-chain polysaccharide. (google.es)
  • 7. The polypeptide fragment of claim 6 wherein the substrate is nitrocellulose or polyester. (google.es)
  • 9. The polypeptide fragment of claim 1 coupled to collagen. (google.es)
  • In its natural form, collagen has a folded triple helix structure consisting of long polypeptide chains (see figure 1). (nutraingredients.com)
  • 2,3 Collagens are proteins that consist of a triple helix of polypeptide chains and globular domains, and comprise a family of proteins of at least 19 genetically distinct types, among which type I and type III constitute two-thirds. (ahajournals.org)
  • Mutations in each of the three collagen VI genes COL6A1, COL6A2 and COL6A3 cause two main types of muscle disorders: Ullrich congenital muscular dystrophy, a severe phenotype, and a mild to moderate phenotype Bethlem myopathy. (nih.gov)
  • The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. (wikipedia.org)
  • Nonetheless, knockdown of mutant COL6A3 in patient fibroblast cells using siRNA has successfully improved cellular deposition of type VI collagen in autosomal dominant UCMD, and may become a promising treatment for it. (wikipedia.org)
  • Mutations in the COL6A1 , COL6A2 , and COL6A3 genes can cause the various forms of collagen VI-related myopathy. (medlineplus.gov)
  • Mutations in the COL6A1 , COL6A2 , and COL6A3 genes result in a decrease or lack of type VI collagen or the production of abnormal type VI collagen. (medlineplus.gov)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Collagen Type VI Alpha 3 (COL6a3) in samples from serum, plasma, tissue homogenates or other biological fluids. (ialltjournal.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Collagen Type VI Alpha 3 (COL6a3) in serum, plasma, tissue homogenates and other biological fluids. (ialltjournal.org)
  • Reverse transcription-PCR amplification performed on RNA extracted from fibroblasts or muscle of three Ullrich patients followed by heteroduplex analysis displayed heteroduplexes in one of the three genes coding for collagen type VI (COL6). (pnas.org)
  • Collagen type I appeared in the form of ramifying string-like structures after approximately 5-6 days, but positive reactions in the form of a spot-like staining around isolated fibroblasts also occurred in a skin wound aged 4 days. (uni-muenchen.de)
  • Collagen VI was detectable after a post-infliction interval of at least 3 days showing a strongly positive reacting network associated with fibroblasts in the wound area. (uni-muenchen.de)
  • Therefore, although a positive reaction for collagen type I in the form of string-like and ramifying structures around wound fibroblasts indicates a wound age of at least 5-6 days, a spot-like positive staining for collagen type I cannot exclude a wound age of at least 4 days. (uni-muenchen.de)
  • This is the collagen of granulation tissue, and is produced quickly by young fibroblasts before the tougher type I collagen is synthesized. (news-medical.net)
  • Individually, the cytotoxic effect of ESAT-6 protein has been found to evoke apoptosis of macrophages, dendritic cells, and fibroblasts [ 11 ]. (hindawi.com)
  • Tendons are specialized tissues composed primarily of load-responsive fibroblasts (tenocytes) embedded in a collagen-rich extracellular matrix. (nature.com)
  • Usage information: A monoclonal antibody to the carboxyterminal domain of procollagen type I visualizes collagen-synthesizing fibroblasts. (jci.org)
  • However, at present there is no simple method for assessing the collagen-synthesizing and secreting activity of fibroblasts in human tissues. (jci.org)
  • Embryonic chick tendon fibroblasts actively synthesizing type I collagen stained heavily with Anti-pC, while quiescent adult tendon fibroblasts did not stain with Anti-pC. (jci.org)
  • Thus, Anti-pC specifically visualized fibroblasts actively synthesizing collagen. (jci.org)
  • The absence of staining in normal lung supports the hypothesis that fibrosis is associated with an altered collagen-synthesizing phenotype of tissue fibroblasts. (jci.org)
  • Bienkowski, R. S. (1984) Collagen degradation in human lung fibroblasts: extent of degradation, role of lysosomal proteases, and evaluation of an alternate hypothesis. (springer.com)
  • 3. The SLS preparation made by collagen synthesized by cultured fibroblasts from an osteogenesis imperfecta patient showed normal as well as abnormal crystallites. (nii.ac.jp)
  • Publications] KOBAYASHI,Kunihiko: 'Direct visualization of affected collagen molecules synthesized by cultured fibroblasts from an osteogenesis imperfecta patient. (nii.ac.jp)
  • Accordingly, we postulated that the PPAR-γ ligand, pioglitazone, which is known to modulate oxidative stress, would alter Ang II-induced formation of collagen type I in cardiac fibroblasts. (ahajournals.org)
  • Cardiac fibroblasts were treated with different concentrations (10 −8 to 10 −6 M) of Ang II for different times (6 hours, 12 hours, and 24 hours). (ahajournals.org)
  • Thus, pioglitazone attenuates Ang II-mediated collagen type I synthesis in cardiac fibroblasts. (ahajournals.org)
  • 3,4 Fibroblasts are the major source of collagen in the myocardium. (ahajournals.org)
  • 3,5 Proliferation of cardiac fibroblasts and deposition of collagen are directly associated with both systolic and diastolic (especially the latter) heart failure. (ahajournals.org)
  • Collagen VI is also found in the interstitial space of many tissues including muscle, tendon, skin, cartilage, and intervertebral discs. (nih.gov)
  • The collagens are a superfamily of proteins that play a role in maintaining the integrity of various tissues. (wikipedia.org)
  • Type VI collagen is a primary component of the extracellular matrix of many connective tissues. (molvis.org)
  • There are 29 genetically distinct collagens present in animal tissues. (news-medical.net)
  • Type I collagen is found throughout the body except in cartilaginous tissues. (news-medical.net)
  • The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance between synthesis and degradation. (springer.com)
  • Tough bundles of collagen, called "collagen fibers" are a major component of the extracellular matrix that supports most tissues and gives cells structure from the outside, but collagen is also found inside certain cells. (newworldencyclopedia.org)
  • There is some covalent crosslinking within the triple helices, and a variable amount of covalent crosslinking between tropocollagen helices, to form the different types of collagen found in different mature tissues. (newworldencyclopedia.org)
  • Collagen is the main component of connective tissues that make up tendons, ligaments, skin and cartilage. (nutraingredients.com)
  • Although it has many important functions in the body, collagen is best known for its structural role - providing a framework for tissues throughout the body. (nutraingredients.com)
  • Even as bountiful in youth, the collagen content of the body step by step decreases with age, leading to thinner, weaker, less resilient tissues through the years.2 Lack of collagen is among the most profound consequences of the aging process. (collagenpro.com)
  • A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. (bioportfolio.com)
  • transmembrane collagen, interacts with integrin a1b1, fibronectin and components of basement membranes like nidogen and perlecan. (news-medical.net)
  • We investigated the binding of oxidized LDL (ox-LDL) to microtiter plates coated with type I or II collagen, laminin, fibronectin, or poly- d -lysine. (ahajournals.org)
  • Application of the F(ab′) 2 from a monoclonal antibody to ox-LDL revealed a strong competition of the binding of highly ox-LDL to type II collagen (60%), laminin (35%), type I collagen (20%), and poly- d -lysine (15%), whereas the binding to fibronectin was not affected. (ahajournals.org)
  • In addition to these collagen phenotypes and poly- d -lysine, we investigated for the first time the binding of ox-LDL to laminin and fibronectin. (ahajournals.org)
  • In the present study, we extracted chondrons from human articular cartilages and investigated the relationship between the distribution of the matrix molecules, including type VI collagen, and the degeneration of articular cartilage. (elsevier.com)
  • Type II collagen is the main component of cartilage. (news-medical.net)
  • Collagen is common in many types of connective tissue , such as loose connective tissue, dense connective tissue, reticular connective tissue, bone , and cartilage . (newworldencyclopedia.org)
  • Implant-type tissue-engineered cartilage derived from human auricular chondrocyte may maintain cartilaginous property even under osteoinductive condition. (bioportfolio.com)
  • [1] ​ ​ Of the 28 different types of collagen that have been identified, type II collagen is the main structural protein in cartilage. (nutraingredients.com)
  • During the aging process, collagen levels deplete in the body, resulting in connective tissue degradation, which manifests as wrinkles, thinning cartilage, and brittle hair. (vitacost.com)
  • Collagen has been widely used for cartilage repair, but its low stiffness and rapid degradation disfavor chondrogenesis. (bioportfolio.com)
  • A fibrillar collagen found primarily in interstitial CARTILAGE. (bioportfolio.com)
  • Formula 707 LifeCare 6-in-1 Pellets offers collagen, glucosamine, chondroitin, MSM and Bromelian to care for your horse's cartilage, tendons, ligaments and joints. (jefferspet.com)
  • Collagen VI is an important component of the extracellular matrix which forms a microfibrillar network that is found in close association with the cell and surrounding basement membrane. (nih.gov)
  • Electronmicroscopically, the sheaths contained multilaminated basement membrane-like material, collagen fibres 20-25 nm thick with a periodicity of 67 nm and broad-banded aggregates with a periodicity of 100 nm (zebra bodies or fibrous long-spacing fibres). (uni-regensburg.de)
  • Type VI collagen (COL6) is an ECM protein located in the interface between the basement membrane and interstitial matrix, where is binds to other ECM proteins and support cell-cell interactions. (acrabstracts.org)
  • The beaded collagen, type VI, was found in the endomysium and the network forming collagen, type IV, was found in the basement membrane. (forskningsdatabasen.dk)
  • To elucidate the role of extracellular matrix and basement membrane associated proteins at the ectodermal-ectomesenchymal interface of developing salivary glands, human fetal submandibular glands (n=100), gestational age varying from 10 to 40 weeks, were evaluated for expression of tenascin, type IV collagen and laminin by using immunohistochemical methods and the results were compared with their expression in adult glands (n=20). (nii.ac.jp)
  • Type IV collagen and laminin were observed in the basement membrane of salivary ducts and acini beginning from 16-18 weeks, and the intensity of reaction was more prominent during intermediate developing stages (19-32 weeks). (nii.ac.jp)
  • The present study suggests that tenascin forms an epithelial-ectomesenchymal interface before the organization of collagen IV and laminin in the basement membrane of salivary ducts and acini in developing human submandibular glands. (nii.ac.jp)
  • We also investigated the effects of interleukin-1β (IL-1β) and transforming growth factor β-1(TGF-β 1 ) on the distribution of type VI collagen in cultured chondrocytes. (elsevier.com)
  • Tendon degeneration led to an increased visibility of these components with a significant disorganization in the distribution of type VI collagen. (ox.ac.uk)
  • Intense staining for type III collagen and hyaluronic acid was found in the connective tissue of the subpapillary layer and between the cherry haemangioma capillaries. (uni-regensburg.de)
  • Much weaker staining for type III collagen and no staining for hyaluronic acid were found invariably in an area 4-10 microns thick directly around the capillaries. (uni-regensburg.de)
  • Multi Collagen Pills with Hyaluronic Acid & Vitamin C: 5 Type. (amzn.com)
  • As part of type VI collagen, this protein has been implicated in Bethlem myopathy, Ullrich congenital muscular dystrophy (UCMD), and other diseases related to muscle and connective tissue. (wikipedia.org)
  • A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. (curehunter.com)
  • To investigate the effect of transforming growth factor (TGF)-β2 on the expression of (1) elastin and type VI collagen (ColVI), (2) extracellular matrix (ECM)-degrading matrix-metalloproteinases (MMPs) and regulators of their activity/activation, and (3) the involvement of connective tissue growth factor (CTGF) in the TGF-β2-mediated regulations in cultured human type-1A and -1B optic nerve astrocytes. (arvojournals.org)
  • Both sheath material and intercapillary connective tissue of the haemangiomas showed pronounced staining for collagen type VI. (uni-regensburg.de)
  • Brittle Cornea Syndrome and Ehlers-Danlos Syndrome (EDS) type VI are rare collagen-connective tissue disorders that predispose affected individuals to the development of perforated corneas from the mildest of eye trauma or even spontaneously. (clinicaltrials.gov)
  • Type VI collagen makes up part of the extracellular matrix that surrounds muscle cells and connective tissue. (medlineplus.gov)
  • As a result, the stability of the surrounding muscle cells and connective tissue progressively declines, which leads to the muscle weakness, contractures, and other signs and symptoms of collagen VI-related myopathy. (medlineplus.gov)
  • A process for extracting type I collagen from an avian source such as poultry feet that incorporates a fibrillar mass of connective tissue as well as bony tissue to yield a collagen product having useful medical and biotechnology applications. (google.co.uk)
  • Collagen is the main protein of connective tissue in animals and the most abundant protein in mammals , making up about 25 percent of the total protein content. (newworldencyclopedia.org)
  • The disease scurvy, traced to vitamin C (ascorbic acid) deficiency, results when defective collagen prevents the formation of strong connective tissue. (newworldencyclopedia.org)
  • Scientifically six-in-one combination to maintain healthy joint and connective tissue. (jefferspet.com)
  • Binding of LDL to connective tissue of the arterial intima, such as various types of collagen, elastin, and glycosaminoglycans, was found to play an important role in the formation of atherosclerotic lesions. (ahajournals.org)
  • Mutations in the genes that code for the collagen VI subunits result in the autosomal dominant disorder, Bethlem myopathy. (wikipedia.org)
  • The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers. (curehunter.com)
  • A distinctive feature of collagen is the regular arrangement of amino acids in each of the three chains of the collagen subunits. (newworldencyclopedia.org)
  • Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer. (bioportfolio.com)
  • Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits. (bioportfolio.com)
  • Immunolocalisations were also undertaken using anti-PG core-protein and glycosaminoglycan (GAG) side chain antibodies to native chondroitin sulphate (CS), Δ C-4-S and C-6-S unsaturated stubs generated by chondroitinase ABC digestion of CS, keratan sulphate (KS), and with antibodies to type I, II, VI, IX and X collagens. (springer.com)
  • Antibodies against collagen types III, IV and VI and laminin were used. (uni-regensburg.de)
  • Anti-Collagen type IX alpha 3 chain antibodies are available from several suppliers. (biocompare.com)
  • Your search returned 92 collagen type IX alpha 3 chain Antibodies across 19 suppliers. (biocompare.com)
  • We describe Western immunoblotting of intact α1(I) collagen using antibodies directed to α1(I) collagen amino and carboxyl propeptides. (springer.com)
  • Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. (lsbio.com)
  • Tsutsumi Y, Tazawa K, Shibuya M. Type VI collagen immunoreactivity in skeinoid fibers in small intestinal stromal tumors. (southernbiotech.com)
  • TGF-β2 induces expression of elastin and ColVI and thereby could contribute to the increase of type VI collagen fibers in the tissue septae and the elastotic changes typically observed in POAG. (arvojournals.org)
  • Distribution and expression of type VI collagen and elastic fibers in human rotator cuff tendon tears. (ox.ac.uk)
  • The collagen IV C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. (wikipedia.org)
  • Mechanical forces regulate extracellular matrix (ECM) synthesis and assembly of collagen fibers. (nature.com)
  • Which cells in the PDL produce the ground substance and Type 1 collagen fibers? (brainscape.com)
  • Repetitive stretching of tendon cells activates the AKT and mTOR pathways, which in turn regulates mRNA translation and collagen expression. (nature.com)
  • In certain cell types (e.g. osteoblasts), mechanical stimulation has been shown to trigger a cascade of AKT/mTOR signaling which regulates the rate of mRNA translation 9 . (nature.com)
  • The measurement of α1(I) collagen mRNA levels using real-time polymerase chain reaction is then outlined. (springer.com)
  • Mutations in the type VI collagen genes are associated with Bethlem myopathy and Ullrich congenital muscular dystrophy (UCMD). (wikipedia.org)
  • The collagen type VI-related disorders are nowadays considered to be a continuum of overlapping phenotypes with Bethlem myopathy at the mild end and Ullrich congenital muscular dystrophy (UCMD) at the severe end. (blueprintgenetics.com)
  • Researchers have described several forms of collagen VI-related myopathy, which range in severity: Bethlem myopathy is the mildest, an intermediate form is moderate in severity, and Ullrich congenital muscular dystrophy is the most severe. (medlineplus.gov)
  • Primary collagen VI deficiency is the second most common congenital muscular dystrophy in Japan. (medscape.com)
  • Bone consists of type I collagen as a major protein with minor various matrix proteins. (nih.gov)
  • Type VI collagen is one of bone matrix proteins but its function is not known. (nih.gov)
  • This is potentially reflective of the specific nature of the trabecular meshwork environment, which facilitates aqueous outflow from the eye, and we speculate that extracellular matrix ions and proteins might prevent a more tight packing of type VI collagen tetramers that form the assemblies. (molvis.org)
  • Since collagen type I and VI are also found in the granulation/scar tissue of lesions with advanced wound age, the immunohistochemical analysis of these proteins provides no further information for an age determination of older skin wounds. (uni-muenchen.de)
  • Two secreted proteins CFP-10 and ESAT-6, produced by the region of difference 1 (RD1) in MTB, have been identified to play important roles in the pathogenesis of tuberculosis [ 6 - 8 ] in primary pulmonary infection. (hindawi.com)
  • This vitamin processes nearly every type of food that you ingest, including carbohydrates, proteins, and fats. (ebay.com)
  • Berg, R. A., Schwartz, M. L., and Crystal, R. G. (1980) Regulation of the production of secretory proteins: intracellular degradation of newly synthesized "defective" collagen. (springer.com)
  • Each module has homologues in other extracellular mosaic proteins such as Von Willebrand factor, slit, thrombospondins, fibrillar collagens, IGF-binding proteins and mucins. (ebi.ac.uk)
  • Its occurrence in collagen types VI, VII, XII and XIV, the integrins and other proteins by averaged structure predictions. (ebi.ac.uk)
  • Collagen is one of the long, fibrous structural proteins whose functions are quite different from those of globular proteins such as enzymes . (newworldencyclopedia.org)
  • 9 10 11 The structure of two scavenger receptors, recently explored by cloning cDNA from bovine lung library and designated type I and type II, was found to contain a collagenous domain, which plays a key role in binding chemically modified proteins, such as acetylated LDL, ox-LDL, and maleylated bovine serum albumin. (ahajournals.org)
  • The ability of the leucine-rich repeat (LRR) proteins biglycan, decorin and chondroadherin to interact with collagen VI and influence its assembly to supramolecular structures was studied by electron microscopy and surface plasmon resonance measurements in the BIAcore 2000 system. (lu.se)
  • However, all three related LRR proteins were shown to interact with collagen VI using electron microscopy and surface plasmon resonance. (lu.se)
  • Serum Markers for Hepatic Fibrosis in Alcoholic Liver Disease: Which is the Best Marker, Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase? (wikipedia.org)
  • Type I procollagen carboxyterminal domains are proteolytically removed during collagen secretion. (jci.org)
  • We developed and characterized a monoclonal antibody (Anti-pC) specific for the carboxyterminal propeptide of type I procollagen. (jci.org)
  • The ratio of α1(I) to α2(I) procollagen chains was about 68:32, indicating that no significant amount of collagen type I trimer was synthesized in this system. (wikiversity.org)
  • Liver fibrosis and cirrhosis are associated with the deposition of collagen IV in the liver. (wikipedia.org)
  • Increased glomerular and mesangial deposition of collagen IV occurs in diabetic nephropathy and increased urinary levels are associated with the extent of renal injury. (wikipedia.org)
  • In addition to the above mentioned disorders, excessive deposition of collagen occurs in scleroderma. (news-medical.net)
  • It was originally identified in pepsin fragments of human aortic intima [ 4 ] and designated as "intima collagen. (molvis.org)
  • Collagen type VI myopathies. (nih.gov)
  • The collagen VI-related myopathies: muscle meets its matrix. (medscape.com)
  • Moreover, perturbation of synthesis or cross-linking of collagen VI alters the size of the condensation in vivo. (nih.gov)
  • this adaptation may occur in part through collagen synthesis or remodeling. (nature.com)
  • To determine the relationship between Anti-pC staining and collagen synthesis, we stained embryonic and adult chicken tendon. (jci.org)
  • Angiotensin II (Ang II)-mediated stimulation of fibroblast growth and collagen type I synthesis is believed to be an important component of the cardiac remodeling process in hypertension and chronic ischemia. (ahajournals.org)
  • These observations indicate that collagen synthesis in these cultured pulp cells was regulated at the transcriptional level. (wikiversity.org)
  • The COL domain presents two short interruptions near the carboxyl end of the triple helix and three of the six potential N-asparaginyl-linked carbohydrate attachment sites (Asn-Xaa-Ser/Thr). (elsevier.com)
  • Under tension, the triple helix coils tight, resisting stretching, and making collagen valuable for structure and support, while giving bones some elasticity. (newworldencyclopedia.org)
  • Rasmussen LM, Hansen PR, Ledet T. Homocysteine and the production of collagens, proliferation and apoptosis in human arterial smooth muscle cells. (southernbiotech.com)
  • Whey and collagen hydrolysate protein inhibit melanoma proliferation in mice treated with paclitaxel. (greenmedinfo.com)
  • Whey and collagen hydrolysates inhibit melanoma cell proliferation. (greenmedinfo.com)
  • TGF-β2 increased the expression of elastin (5×[rtPCR]/6×[WB]), ColVIα2 (3×/5×), ColVIα3 (7×/9×), MMP-2 (2×/2×), TIMP-1/-3 (1.5×/2×), and PAI-1 (8×/4×) compared to untreated controls. (arvojournals.org)
  • Studies in animal models have identified type VI collagen, fibrillin-1 and elastin to be located in the pericellular matrix of tendon and contribute in maintaining the structural and biomechanical integrity of tendon. (ox.ac.uk)
  • At the genetic level, an increase in tear size was linked to an increased transcription of type VI collagen and fibrillin-1 with no significant alteration in the elastin levels. (ox.ac.uk)
  • This is the first study to confirm the localization of type VI collagen, elastin and fibrillin-1 in the pericellular region of human supraspinatus tendon and assesses the effect of tendon degeneration on these structures, thus providing a useful insight into the composition of human rotator cuff tears which can be instrumental in predicting disease prognosis. (ox.ac.uk)
  • The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. (wikipedia.org)
  • The accumulation of type VI collagen around a chondrocyte was obviously increased by the addition of TGF-β 1 . (elsevier.com)
  • Here, we show that mesenchymal cell compaction induces accumulation of collagen VI in the extracellular matrix (ECM), which physically stabilizes compressed mesenchymal cell shapes and ensures efficient organ-specific cell fate switching during tooth organ development. (nih.gov)
  • 6 Collagen type I accumulation in the heart depends not only on its production, but also on its degradation, which is performed by proteinases, such as matrix metalloproteinase-1 (MMP-1). (ahajournals.org)
  • 6 7 Accumulation of lipids in macrophages leads to an enhanced transformation of these cells to so-called foam cells, which are typical cells in early atherosclerotic lesions. (ahajournals.org)
  • Bethlem myopathy (BM) is transmitted as an autosomal dominant disorder and is associated with mutations in collagen VI (COL6) genes ( 7 , 8 ). (pnas.org)
  • Typically, both Bethlem myopathy and autosomal recessive UCMD patients are heterozygous for mutations in the three type VI collagen alpha chains, but only the former exhibit symptoms. (wikipedia.org)
  • In between these phenotypes there are collagen type VI-related limb-girdle muscular dystrophy and myosclerosis myopathy. (blueprintgenetics.com)
  • The intermediate form of collagen VI-related myopathy is characterized by muscle weakness that begins in infancy. (medlineplus.gov)
  • Individuals with collagen VI-related myopathy often have signs and symptoms of multiple forms of this condition, so it can be difficult to assign a specific diagnosis. (medlineplus.gov)
  • While it is difficult to predict which type of mutation will lead to which form of collagen VI-related myopathy, in general, lower amounts of type VI collagen lead to more severe signs and symptoms that begin earlier in life. (medlineplus.gov)
  • Mutations in the type VI collagen genes are associated with Bethlem myopathy, a rare autosomal dominant proximal myopathy with early childhood onset. (lsbio.com)
  • Novel mutations in collagen VI genes: expansion of the Bethlem myopathy phenotype. (medscape.com)
  • Autosomal recessive myosclerosis myopathy is a collagen VI disorder. (medscape.com)
  • The tropocollagen or "collagen molecule" subunit is a rod about 300 nm long and 1.5 nm in diameter. (newworldencyclopedia.org)
  • Here, we uncover the structural basis for both chain selection and stagger formation of a collagen molecule. (rcsb.org)
  • This protein is an alpha chain of type VI collagen that aids in microfibril formation. (wikipedia.org)
  • The alpha 3 chain of type VI collagen is much larger than the alpha 1 and 2 chains. (wikipedia.org)
  • This difference in size is largely due to an increase in the number of subdomains, similar to von Willebrand Factor type A domains, found in the amino terminal globular domain of all the alpha chains. (wikipedia.org)
  • Accessibilome of Human Glioblastoma: Collagen-VI-alpha-1 Is a New Target and a Marker of Poor Outcome. (creativebiomart.net)
  • The alpha-3 subunit (COL4A3) of collagen IV is thought to be the antigen implicated in Goodpasture syndrome , wherein the immune system attacks the basement membranes of the glomeruli and the alveoli upon the antigenic site on the alpha-3 subunit becomes unsequestered due to environmental exposures. (wikipedia.org)
  • Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-5(VI) or alpha-6(VI). (genecards.org)
  • Differential interactions of decorin and decorin mutants with type I and type VI collagens. (nih.gov)
  • The small leucine-rich proteoglycan decorin can bind via its core protein to different types of collagens such as type I and type VI. (nih.gov)
  • In a solid phase assay dissociation constants for wild-type decorin bound to methylated, therefore monomeric, triple helical type I collagen were in the order of 10(-10) m, while dissociation constants for fibrillar type I collagen were approximately 10(-9) m. (nih.gov)
  • Using real-time analysis for a more detailed investigation DCN E180Q and DCN E180K exhibited lower association and higher dissociation constants to type I collagen, compared to wild-type decorin, deviating by at least one order of magnitude. (nih.gov)
  • In contrast, the affinities of these mutants to type VI collagen were 10 times higher than the affinity of wild-type decorin (K(D) approximately 10(-8) m). (nih.gov)
  • Further investigations verified that complexes of type VI collagen and decorin bound type I collagen and that the affinity of collagen type VI to type I was increased by the presence of decorin. (nih.gov)
  • These data show that decorin not only can regulate collagen fibril formation but that it also can act as an intermediary between type I and type VI collagen and that these two types of collagen interact via different binding sites. (nih.gov)
  • Chondrogenic hMSCs develop a thin pericellular matrix (PCM), consisting of type VI collagen (ColVI) and proteoglycans such as decorin (DCN). (umd.edu)
  • Intact decorin, with one dermatan sulfate chain only, was considerably less efficient and aggregates of organized collagen VI were found only after several hours. (lu.se)
  • Biglycan and decorin were exclusively found close to the N-terminal parts of the collagen VI tetramers while chondroadherin was shown to bind close to both the N- and C-terminal parts of collagen VI. (lu.se)
  • This chapter outlines several methods to assess the in vitro production of type I collagen that are employed in our laboratory. (springer.com)
  • 8 On the other hand, ox-LDL was shown in vitro to bind to collagen gels. (ahajournals.org)
  • Also, collagen IV lacks the regular glycine in every third residue necessary for the tight, collagen helix . (wikipedia.org)
  • Mutations to the genes coding for collagen IV lead to Alport syndrome . (wikipedia.org)
  • They enable endothelial cells to attach to underlying extracellular matrix by binding to collagen and they interact with fibrin, heparin, and integrins. (ahajournals.org)
  • There may be defects in collagen secretion and general production as well. (news-medical.net)
  • Collagen-related diseases most commonly arise from genetic defects or nutritional deficiencies that affect the biosynthesis, assembly, postranslational modification, secretion, or other processes involved in normal collagen production. (news-medical.net)
  • Type VI collagen (COL6), an extracellular matrix protein, is important in maintaining the integrity of lung tissue. (elsevier.com)
  • The enzyme-treated comminuted material which is rich in collagen is dispersed in an organic acid to cause the fibrillar mass to undergo controlled swelling, after which the mass is separated from the bony tissue and purified to remove non-collangenous material. (google.co.uk)
  • We confirmed that C57BL/6 mice are susceptible to arthritis induced by immunisation with chicken type II collagen and develop strong and sustained T-cell responses to type II collagen. (ox.ac.uk)
  • Chicken collagen hydrolysate protects rats from hypertension and cardiovascular damage. (greenmedinfo.com)
  • Serving Size: Two (2) tablets Ingredients: Hydrolyzed Collagen (chicken) 600 mg Proprietary Advanced Joint Blend: 500 mg Boswelia (Indian Frankincense)(gum) Extract (65% boswellic acids), Cinnamon (bark)(Cinnamomum cassia) extract (4:1), Turmeric (rhizome)(Curcuma longa) extract (95% curcuminoids), Quercetin Dihydrate. (collagenpro.com)
  • Corrigendum to 'An injectable collagen-genipin-carbon dot hydrogel combined with photodynamic therapy to enhance chondrogenesis' Biomaterials 218 (2019) 119190. (bioportfolio.com)
  • Electron-dense collagen structures were detected in the human trabecular meshwork and identified as collagen type VI assemblies based on the three-dimensional spatial arrangement of the type VI collagen molecules, the 105-nm axial periodicity of the assemblies themselves, and their characteristic double bands, which arose from the globular domains of the type VI collagen molecules. (molvis.org)
  • The same interactions between globular domains of the tetramers also account for the formation of more extended collagen VI aggregates [ 21 ] resembling open networks. (molvis.org)
  • Genetically, UCMD and BM are caused by mutations in the genes encoding for the three α-chains of the collagen type VI acting in a recessive or dominant way. (unipd.it)
  • Fitzgerald, J., Lamande, S. R., and Bateman, J. F. (1999) Proteasomal degradation of unassembled mutant type I collagen pro-alpha1(I) chains. (springer.com)
  • There are homo- and hetero-trimeric types of collagen consisting of one, two or three distinct chains. (rcsb.org)
  • Three distinct chains (α1, α2 and α3) of the non-collagenous domain 2 (NC2) of type IX collagen are assembled to guide triple-helical sequences in the leading, middle and trailing positions. (rcsb.org)
  • In other experiments, we observed that trolox, the water soluble analog of vitamin E, attenuated the effects of Ang II on the expression of collagen type I and MMP-1, in a manner similar to pioglitazone. (ahajournals.org)
  • These defects often cause problems in the biosynthesis of the collagen molecules, their assembly and posttranslational modification process that makes them their final end form of collagen. (news-medical.net)
  • Collagen VI is a major structural component of microfibrils. (wikipedia.org)
  • No extended structural regularity in the organization of type VI collagen assemblies within the trabecular meshwork was evident, and the lateral separation of the tetramers forming the assemblies varied, as did the angle formed by the main axes of adjacent tetramers. (molvis.org)
  • Cysteine residues form disulfide bridges between monomers in dimers and between dimers in tetramers [ 19 ], and they stabilize the main collagen VI structural unit. (molvis.org)
  • The present sequence data allow a structural model for type VI collagen assembly to be proposed that is consistent with the structure implied from previous electron microscopic observation by Furthmayr et al. (elsevier.com)
  • In addition to the well known presence of type I fibrous collagen, types III and VI were also found in the myocommata and the endomysium. (forskningsdatabasen.dk)