Collagen type vi. Medical search

A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers.

A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).

Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).

The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.

Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.

A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.

A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.

A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.

A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.

A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE.

In GRAM NEGATIVE BACTERIA, multiprotein complexes that function to translocate pathogen protein effector molecules across the bacterial cell envelope, often directly into the host. These effectors are involved in producing surface structures for adhesion, bacterial motility, manipulation of host functions, modulation of host defense responses, and other functions involved in facilitating survival of the pathogen. Several of the systems have homologous components functioning similarly in GRAM POSITIVE BACTERIA.

Mucopolysaccharidosis with excessive CHONDROITIN SULFATE B in urine, characterized by dwarfism and deafness. It is caused by a deficiency of N-ACETYLGALACTOSAMINE-4-SULFATASE (arylsulfatase B).

A fibrillar collagen found primarily in interstitial CARTILAGE. Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits.

A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.

Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI.

An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.

Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.

Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

A hepatic GLYCOGEN STORAGE DISEASE in which there is an apparent deficiency of hepatic phosphorylase (GLYCOGEN PHOSPHORYLASE, LIVER FORM) activity.

A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.

A non-fibrillar collagen found in BASEMENT MEMBRANE. The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage.

A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.

Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

A non-fibrillar collagen found primarily in terminally differentiated hypertrophic CHONDROCYTES. It is a homotrimer of three identical alpha1(X) subunits.

A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.

A fibril-associated collagen found in many tissues bearing high tensile stress, such as TENDONS and LIGAMENTS. It is comprised of a trimer of three identical alpha1(XII) chains.

A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.

A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.

Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M. (1/145)

The binding of certain growth factors and cytokines to components of the extracellular matrix can regulate their local availability and modulate their biological activities. We show that oncostatin M (OSM), a profibrogenic cytokine and modulator of cancer cell proliferation, specifically binds to collagen types I, III, IV, and VI, immobilized on polystyrene or nitrocellulose. Single collagen chains inhibit these interactions in a dose-dependent manner. Cross-inhibition experiments of collagen-derived peptides point to a limited set of OSM-binding collagenous consensus sequences. Furthermore, this interaction is found for OSM but not for other interleukin-6 type cytokines. OSM binding to collagens is saturable, with dissociation constants around 10(-8) m and estimated molar ratios of 1-3 molecules of OSM bound to one molecule of triple helical collagen. Furthermore, collagen-bound OSM is biologically active and able to inhibit proliferation of A375 melanoma cells. We conclude that abundant interstitial collagens dictate the spatial pattern of bioavailable OSM. This interaction could be exploited for devising collagenous peptide-antagonists that modulate OSM bioactivity in tumor growth and fibrotic disorders like rheumatoid arthritis and hepatic fibrosis. (+info)

Flexibility and packing in proteins. (2/145)

Structural flexibility is an essential attribute, without which few proteins could carry out their biological functions. Much information about protein flexibility has come from x-ray crystallography, in the form of atomic mean-square displacements (AMSDs) or B factors. Profiles showing the AMSD variation along the polypeptide chain are usually interpreted in dynamical terms but are ultimately governed by the local features of a highly complex energy landscape. Here, we bypass this complexity by showing that the AMSD profile is essentially determined by spatial variations in local packing density. On the basis of elementary statistical mechanics and generic features of atomic distributions in proteins, we predict a direct inverse proportionality between the AMSD and the contact density, i.e., the number of noncovalent neighbor atoms within a local region of approximately 1.5 nm(3) volume. Testing this local density model against a set of high-quality crystal structures of 38 nonhomologous proteins, we find that it accurately and consistently reproduces the prominent peaks in the AMSD profile and even captures minor features, such as the periodic AMSD variation within alpha helices. The predicted rigidifying effect of crystal contacts also agrees with experimental data. With regard to accuracy and computational efficiency, the model is clearly superior to its predecessors. The quantitative link between flexibility and packing density found here implies that AMSDs provide little independent information beyond that contained in the mean atomic coordinates. (+info)

Differential gene expression in human abdominal aorta: aneurysmal versus occlusive disease. (3/145)

OBJECTIVE: Inflammation and atherosclerosis are present in both abdominal aortic aneurysm (AAA) and arterial occlusive disease (AOD). Changes in gene expression that underlie the development of AAA versus AOD are poorly defined. This study evaluated differences in gene expression in AAA, AOD, and control aortic tissue with human gene array technology. METHODS: RNA was isolated from human aortic specimens (seven AAA, five AOD, and five control), and complementary DNA (cDNA) probes were generated. The cDNA probes were hybridized to a human cell interaction array of 265 genes and quantitated with phosphorimaging. The data were corrected for background and were standardized to housekeeping genes. Statistical differences in individual gene expression were determined with the Kruskal-Wallis test. RESULTS: Of 265 genes studied, 11 showed statistically different expression in diseased aorta as compared with control. The following three genes were downregulated in AAA: collagen VI alpha1 (P <.037), glycoprotein IIIA (P <.006), and alpha2-macroglobulin (P <.020). The following two genes were upregulated in AOD: laminin alpha4 (P <.034) and insulin-like growth factor 2 receptor (P <.049). The following three genes were upregulated in both AAA and AOD: matrix metalloproteinase-9 (MMP-9; P <.005), intercellular adhesion molecule-1 (P <.012), and tumor necrosis factor--beta receptor (P <.022). The following three genes were downregulated in both AAA and AOD: integrin alpha5 (P <.012), ephrin A5 (P <.037), and rho/rac guanine nucleotide exchange factor (P <.028). Of 16 MMPs evaluated, only MMP-9 was significantly (P <.005) upregulated in both AAA and AOD. Evaluation results of four tissue inhibitors of metalloproteinases showed no significant difference in expression for all tissue types, although tissue inhibitor of metalloproteinase-1 trended toward upregulation in AAA (P =.053). Eight of the fifteen most highly expressed genes in all the groups were extracellular matrix or secreted proteins. Of these, only collagen VI alpha1 (P <.037) showed a significant change, although biglycan trended toward downregulation in AAA (P =.076). CONCLUSION: This study used cDNA array technology in the comparison of human control and pathologic aortic tissue. Six genes had similar differential expression in both AAA and AOD as compared with control. Even more interesting were differences between AAA and AOD in the expression of five genes. These data suggest a similarity in genetic expression for both AAA and AOD, with altered expression of several genes playing a role in disease differentiation. (+info)

Antibody response against perlecan and collagen types IV and VI in chronic renal allograft rejection in the rat. (4/145)

Chronic rejection is the leading cause of late renal transplant failure. Various structural lesions are observed in grafts undergoing chronic rejection including glomerular basement membrane (GBM) duplications. The well-established Fisher (F344) to Lewis (LEW) rat renal transplant model for chronic rejection was used to assess the presence and role of the humoral immune response against graft antigens during chronic rejection. LEW recipients of F344 allografts develop transplant glomerulopathy and produce IgG1 antibodies directed against F344 GBM preparations that are detectable 3 weeks after transplantation. Glomerular IgG1 deposition was observed that in vitro co-localized with a rabbit anti-rat GBM antiserum in rejecting F344 grafts; elution experiments of isolated glomeruli yielded IgG1 antibodies reactive in vitro with F344 GBM, but not LEW GBM. Prevention of acute rejection by transient treatment of the recipients with cyclosporin A completely abrogated the production of anti-GBM antibodies. Using proteomic techniques we identified the antigens recognized by the LEW posttransplant sera as being the heparan sulfate proteoglycan perlecan and the alpha1 chain of collagen type VI in association with the alpha5 chain of collagen type IV. In conclusion, LEW recipients of F344 kidney grafts produce IgG1 antibodies against donor type perlecan and alpha1(VI)/alpha5(IV) collagen and develop transplant glomerulopathy. These data implicate an important role for the humoral immune response in the development of glomerulopathy during chronic rejection. (+info)

The influence of the pericellular microenvironment on the chondrocyte response to osmotic challenge. (5/145)

OBJECTIVE: To examine whether differences in the pericellular microenvironment of different chondron preparations influence the chondrocyte volume regulatory response to experimental osmotic challenge. DESIGN: Mechanically extracted chondrons (MC), enzymatically extracted chondrons (EC) and isolated chondrocytes (IC) were seeded into agarose and sampled at 1, 3 and 7 days. Samples mounted in a perfusion chamber were subjected to osmotic challenge. The cross-sectional areas of the chondrocyte and pericellular microenvironment were measured under isotonic, hypertonic and hypotonic conditions, and percentage change calculated. Separate samples were immunolabeled for type VI collagen and keratan sulfate. RESULTS: Initially, the microenvironment of MC represented 60% of the chondron area and was occupied by type VI collagen and keratan sulfate. In EC, the microenvironment comprised 18% of the chondron area with narrow bands of type VI collagen and keratan sulfate. IC had no visible microenvironment, with small amounts of type VI collagen and keratan sulfate present. All preparations sequestered additional pericellular macromolecules during culture. Under isotonic conditions, the EC and IC chondrocytes were larger than those of MC. All chondrocytes shrank under hypertonic conditions and swelled under hypotonic conditions. MC were the least responsive, displaying the most efficient volume regulation. IC showed the largest response initially but this decreased with time. EC exhibited intermediate responses that decreased as the microenvironment increased in size. CONCLUSIONS: The composition and structural integrity of the pericellular microenvironment do influence the cellular response to experimental osmotic challenge. This suggests that the microenvironment functions in situ to mediate the chondrocyte response to physicochemical changes associated with joint loading. (+info)

Mutations in COL6A3 cause severe and mild phenotypes of Ullrich congenital muscular dystrophy. (6/145)

Ullrich congenital muscular dystrophy (UCMD) is an autosomal recessive disorder characterized by generalized muscular weakness, contractures of multiple joints, and distal hyperextensibility. Homozygous and compound heterozygous mutations of COL6A2 on chromosome 21q22 have recently been shown to cause UCMD. We performed a genomewide screening with microsatellite markers in a consanguineous family with three sibs affected with UCMD. Linkage of the disease to chromosome 2q37 was found in this family and in two others. We analyzed COL6A3, which encodes the alpha3 chain of collagen VI, and identified one homozygous mutation per family. In family I, the three sibs carried an A-->G transition in the splice-donor site of intron 29 (6930+5A-->G), leading to the skipping of exon 29, a partial reduction of collagen VI in muscle biopsy, and an intermediate phenotype. In family II, the patient had an unusual mild phenotype, despite a nonsense mutation, R465X, in exon 5. Analysis of the patient's COL6A3 transcripts showed the presence of various mRNA species-one of which lacked several exons, including the exon containing the nonsense mutation. The deleted splice variant encodes collagen molecules that have a shorter N-terminal domain but that may assemble with other chains and retain a functional role. This could explain the mild phenotype of the patient who was still ambulant at age 18 years and who showed an unusual combination of hyperlaxity and finger contractures. In family III, the patient had a nonsense mutation, R2342X, causing absence of collagen VI in muscle and fibroblasts, and a severe phenotype, as has been described in patients with UCMD. Mutations in COL6A3 are described in UCMD for the first time and illustrate the wide spectrum of phenotypes which can be caused by collagen VI deficiency. (+info)

Isolation of up- or down-regulated genes in PPARgamma-expressing NIH-3T3 cells during differentiation into adipocytes. (7/145)

Adipocyte differentiation is a complex process in which the expression of many transcription factors and adipocyte-specific genes is regulated under a strict program. The peroxisome proliferator-activated receptor gamma (PPARgamma), a member of the steroid/thyroid nuclear hormone receptor superfamily of ligand-activated transcription factors, is an important regulator of adipocyte gene expression and differentiation. In this study, we tried to identify downstream target genes of PPARgamma, by using PPARgamma-expressing cells and a subtractive cloning strategy, and isolated cDNA clones which were up-regulated or down-regulated by PPARgamma. Northern blot analyses revealed that the expression levels of the aldehyde dehydrogenase-2-like, type VI collagen alpha 3 subunit, cellular retinoic acid binding protein 1 and thrombospondin 1 are changed during the differentiation of mouse 3T3-L1 preadipocyte cells, indicating that these genes might be downstream targets of PPARgamma in adipocyte differentiation. (+info)

Identification of known and novel genes whose expression is regulated by endogenous retinoic acid during early embryonic development of the mouse. (8/145)

Retinoic acid (RA) derived from vitamin A is necessary for, among other things, mammalian embryonic development. Although the impact of RA-dependent gene-regulation on embryonic development has been examined through genetic disruption of the retinoid receptors, the understanding of the underlying molecular mechanism remain unclear, in part, due to the difficulty in identifying RA-regulated genes in an intact embryo. We report here that RA-regulated genes can be identified from total RA-deficient embryos created by retinol-binding protein antisense (RBP-AS) oligodeoxynucleotide treatment in conjunction with differential display. Of the 28 genes isolated, 15 genes matched known genes in the GenBank database and the others either represented EST sequences or encoded novel genes. Semi-quantitative reverse transcriptase-polymerase chain reaction verified that the mRNA levels of mouse DN 38, COL VI 3 alpha, cul-1, alpha-tropomyosin, and PP2A-C alpha were substantially increased, whereas mouse Msh 2, Ndufa2, Ribosomal protein S19, sFRP-1, GDAP-10 and mSmcD were significantly decreased in vitamin A deficient (VAD) embryos compared to the control embryos. The utility of the method is exemplified by our finding that several genes in the Wnt signaling pathway are vitamin A regulated in day 9.0 post coitum (p.c.) embryos. (+info)

Symptoms of MPS VI typically become apparent in the first year of life and can include:

* Coarsening of facial features
* Enlarged liver and spleen
* Short stature
* Joint stiffness and progressive joint degeneration
* Corneal clouding
* Sleep apnea
* Heart valve problems
* Respiratory difficulties

MPS VI is diagnosed through a combination of physical examination, medical history, and laboratory tests, including enzyme assays and genetic analysis. There is currently no cure for MPS VI, but various treatments are available to manage the symptoms and improve quality of life. These may include:

* Enzyme replacement therapy (ERT) to replace the missing NAGLU enzyme
* Bone marrow transplantation to correct the genetic defect and restore normal enzyme function
* Physical therapy to maintain joint mobility and prevent contractures
* Respiratory support to manage breathing difficulties
* Cardiac monitoring and treatment to address heart valve problems

Early diagnosis and appropriate management of MPS VI can help to improve the quality of life for affected individuals, but it is important to note that this condition is a lifelong condition and ongoing medical care will be necessary.

Symptoms of GSD VI typically appear during infancy or early childhood and may include:

* Delayed development and growth
* Poor muscle tone and weakness
* Increased risk of hypoglycemia (low blood sugar)
* Liver enlargement
* Yellowing of the skin and eyes (jaundice)
* Increased risk of infections and other health problems.

GSD VI is diagnosed through a combination of clinical evaluation, laboratory tests, and genetic analysis. Treatment for the condition typically involves a high-carbohydrate diet, regular monitoring of blood sugar levels, and managing any associated health problems. In some cases, liver transplantation may be necessary.

Glycogen storage disease type VI is a rare and debilitating disorder that can significantly impact the quality of life of affected individuals and their families. It is important to work with a team of healthcare professionals to manage the condition and provide appropriate support and resources.

"Entrez Gene: COL6A1 collagen, type VI, alpha 1". Bertini E, Pepe G (2002). "Collagen type VI and related disorders: Bethlem ... The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI ... 1989). "Sequence analysis of alpha 1(VI) and alpha 2(VI) chains of human type VI collagen reveals internal triplication of ... "Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen". J. Biol. Chem. 272 (42): 26522-9 ...

https://en.wikipedia.org/wiki/Collagen,_type_VI,_alpha_1

This protein is an alpha chain of type VI collagen that aids in microfibril formation. As part of type VI collagen, this ... type VI, alpha 3". Lamandé SR, Mörgelin M, Adams NE, Selan C, Allen JM (Jun 2006). "The C5 domain of the collagen VI alpha3(VI ... "Structure and multiple conformations of the kunitz-type domain from human type VI collagen alpha3(VI) chain in solution". ... chain in collagen VI assembly. Expression of an alpha3(VI) chain lacking N-terminal modules N10-N7 restores collagen VI ...

https://en.wikipedia.org/wiki/Collagen,_type_VI,_alpha_3

"Entrez Gene: COL6A2 collagen, type VI, alpha 2". Bertini E, Pepe G (2002). "Collagen type VI and related disorders: Bethlem ... 1989). "Sequence analysis of alpha 1(VI) and alpha 2(VI) chains of human type VI collagen reveals internal triplication of ... "Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen". J. Biol. Chem. 272 (42): 26522-9 ... This gene encodes one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective ...

https://en.wikipedia.org/wiki/Collagen,_type_VI,_alpha_2

COL6A5 is a part of the Collagen VI gene family which produce collagen components for the Extracellular matrix of most ... Collagen alpha-5(VI) chain also known as von Willebrand factor A domain-containing protein 4 is a protein that in humans is ... In the human genome, part of the collagen VI family is located on chromosome 3q in order of COL6A4, COL6A5, COL6A6. ... Fitzgerald J, Holden P, Hansen U (2013). "The expanded collagen VI family: new chains and new questions". Connective Tissue ...

https://en.wikipedia.org/wiki/Collagen,_type_VI,_alpha_5

... this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the ... This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Like the ... of type IV collagen in synovial capillaries by immunohistochemistry using a monoclonal antibody against human type IV collagen ... collagen chain and comparison with other type IV collagen genes". J. Biol. Chem. 270 (45): 26863-7. doi:10.1074/jbc.270.45. ...

https://en.wikipedia.org/wiki/Collagen,_type_IV,_alpha_6

Lampe AK, Flanigan KM, Bushby KM, Hicks D (August 9, 2012). "Collagen VI-Related Dystrophies". Collagen Type VI-Related ... Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen. J. Biol. Chem. 272, 26522-26529. ... Collagen VI (ColVI) is a type of collagen primarily associated with the extracellular matrix of skeletal muscle. ColVI ... Role of Collagen VI in Knee Function Studies have revealed that the mutation or deletion of genes encoding for collagen VI can ...

https://en.wikipedia.org/wiki/Collagen_VI

Type XV collagen is known to be a tumor suppressor that can be used to understand tumor cells environment. Type XV collagen ... This gene encodes the alpha chain of type XV collagen, a member of the FACIT collagen family (fibril-associated collagens with ... "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are expressed ... Hägg PM, Hägg PO, Peltonen S, Autio-Harmainen H, Pihlajaniemi T (June 1997). "Location of type XV collagen in human tissues and ...

https://en.wikipedia.org/wiki/Collagen,_type_XV,_alpha_1

This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha ... Epidermolysis bullosa acquisita involves an autoimmune reaction to this form of collagen. Collagen, type VII, alpha 1 forms a ... of type VII collagen is amino-terminal and chimeric. Homology to cartilage matrix protein, the type III domains of fibronectin ... including laminin-5 and collagen IV, contribute greatly to the overall stability of the basement membrane. Type VII collagen is ...

https://en.wikipedia.org/wiki/Collagen,_type_VII,_alpha_1

The COL11A1 gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. Type XI collagen is a ... collagen cDNA demonstrates that type XI belongs to the fibrillar class of collagens and reveals that the expression of the gene ... "Entrez Gene: COL11A1 collagen, type XI, alpha 1". GeneReviews/NCBI/NIH/UW entry on Stickler Syndrome Yoshioka H, Ramirez F ( ... Keene DR, Oxford JT, Morris NP (1995). "Ultrastructural localization of collagen types II, IX, and XI in the growth plate of ...

https://en.wikipedia.org/wiki/Collagen,_type_XI,_alpha_1

... also known as COL28A1 is a protein that in humans is encoded by the COL28A1 gene. This protein ... "COL28A1 collagen, type XXVIII, alpha 1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2015-09-25. v t e ... belongs to a class of collagens that contain von Willebrand factor type A domains. The protein is encoded by the COL28A1 gene ... Veit G, Kobbe B, Keene DR, Paulsson M, Koch M, Wagener R (Feb 2006). "Collagen XXVIII, a novel von Willebrand factor A domain- ...

https://en.wikipedia.org/wiki/Collagen,_type_XXVIII,_alpha_1

... chain of type II collagen. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and ... "A COL2A1 mutation in achondrogenesis type II results in the replacement of type II collagen by type I and III collagens in ... type 2 by affecting tissues that are rich in type II collagen. Platyspondylic lethal skeletal dysplasia, Torrance type:Fewer ... chain that cannot be incorporated into type II collagen fibers. As a result, cells make a reduced amount of type II collagen. ...

https://en.wikipedia.org/wiki/Collagen,_type_II,_alpha_1

It is ubiquitously expressed in many tissues and cell types. COL4A1 is a subunit of the type IV collagen and plays a role in ... collagen". FEBS Letters. 225 (1-2): 188-94. doi:10.1016/0014-5793(87)81155-9. PMID 3691802. "Entrez Gene: COL4A1 collagen, type ... Type IV collagen is the major structural component of basement membranes, which contains two or three COL4A1 proteins. Thus, ... COL4A1 belongs to the type IV collagen family and contains three domains: a short N-terminal domain, a long triple-helical 7S ...

https://en.wikipedia.org/wiki/Collagen,_type_IV,_alpha_1

... collagen family. Type XII collagen is a homotrimer found in association with type I collagen, an association that is thought to ... This gene encodes the alpha chain of type XII collagen, a member of the FACIT (fibril-associated collagens with interrupted ... collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". Genomics ... "Entrez Gene: COL12A1 collagen, type XII, alpha 1". Oh SP, Taylor RW, Gerecke DR, et al. (1992). "The mouse alpha 1(XII) and ...

https://en.wikipedia.org/wiki/Collagen,_type_XII,_alpha_1

This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with ... Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to ... "Entrez Gene: COL16A1 collagen, type XVI, alpha 1". Yamaguchi N, Kimura S, McBride OW, Hori H, Yamada Y, Kanamori T, Yamakoshi H ... High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion. GRCh38: ...

https://en.wikipedia.org/wiki/Collagen,_type_XVI,_alpha_1

... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... This gene encodes one of the chains for type I collagen, the fibrillar collagen found in most connective tissues. Mutations in ... Type-I collagen Collagen GRCh38: Ensembl release 89: ENSG00000164692 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... "Entrez Gene: COL1A2 collagen, type I, alpha 2". Byers PH, Wallis GA, Willing MC (1991). "Osteogenesis imperfecta: translation ...

https://en.wikipedia.org/wiki/Collagen,_type_I,_alpha_2

There are various types of collagen which have individual roles and structures. Most collagen belongs to types 1, 2 and 3. ... Research shows that type 1 collagen reduces in amount when exposed to UV light because of the dilapidation of the collagen. ... Ferraro V, Gaillard-Martinie B, Sayd T, Chambon C, Anton M, Santé-Lhoutellier V (April 2017). "Collagen type I from bovine bone ... When an individual intakes large amounts of sugar the process of glycation converts the collagen into an unstable type 1 which ...

https://en.wikipedia.org/wiki/Collagen_loss

Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. ... "Entrez Gene: COL9A3 collagen, type IX, alpha 3". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...

https://en.wikipedia.org/wiki/Collagen,_type_IX,_alpha_3

Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, a collagen component of hyaline cartilage. ... "Entrez Gene: COL9A1 collagen, type IX, alpha 1". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...

https://en.wikipedia.org/wiki/Collagen,_type_IX,_alpha_1

Type IX collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. ... "Entrez Gene: COL9A2 collagen, type IX, alpha 2". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...

https://en.wikipedia.org/wiki/Collagen,_type_IX,_alpha_2

"Entrez Gene: COL23A1 collagen, type XXIII, alpha 1". Banyard J, Bao L, Zetter BR (June 2003). "Type XXIII collagen, a new ... The molecule of collagen XXIII can be found either in membrane-bond form or in shed form. Type XXIII collagen is expressed in ... Collagen XXIII is a type II transmembrane protein and the fourth in the subfamily of non-fibrillar transmembranous collagens. ... Collagen XXIII shows structural homology with collagen XIII and collagen XXV . Apart from having the characteristic structure ...

https://en.wikipedia.org/wiki/Collagen,_type_XXIII,_alpha_1

"Entrez Gene: COL8A1 collagen, type VIII, alpha 1". Shuttleworth CA (1998). "Type VIII collagen". Int. J. Biochem. Cell Biol. 29 ... This gene encodes one of the two alpha chains of type VIII collagen. The gene product is a short chain collagen and a major ... Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ... The type VIII collagen fibril can be either a homo- or a heterotrimer. Alternatively spliced transcript variants encoding the ...

https://en.wikipedia.org/wiki/Collagen,_type_VIII,_alpha_1

Juvonen M, Sandberg M, Pihlajaniemi T (1992). "Patterns of expression of the six alternatively spliced exons affecting the ... Latvanlehto A, Snellman A, Tu H, Pihlajaniemi T (2003). "Type XIII collagen and some other transmembrane collagens contain two ... Collagen XIII belongs to the transmembranous subfamily of collagens, like collagen XVII, XXIII and XXV. GRCh38: Ensembl release ... 2002). "The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and ...

https://en.wikipedia.org/wiki/Collagen,_type_XIII,_alpha_1

Type XXVII collagen is related to the "fibrillar" class of collagens and may play a role in development of the skeleton. ... COL27A1 is a type XXVII collagen. It was discovered by James Pace. This gene appears to be turned on in cartilage, the eye, and ... Fibrillar collagens, such as COL27A1, compose one of the most ancient families of extracellular matrix molecules. They form ... Collagen alpha-1 (XXVII) chain (COL27A1) is a protein that in humans is encoded by the COL27A1 gene. ...

https://en.wikipedia.org/wiki/Collagen,_type_XXVII,_alpha_1

... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ... "Entrez Gene: COL5A3 collagen, type V, alpha 3". van der Rest M, Garrone R (1991). "Collagen family of proteins". FASEB J. 5 (13 ...

https://en.wikipedia.org/wiki/Collagen,_type_V,_alpha_3

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C- ... "Duplication of type IV collagen COOH-terminal repeats and species-specific expression of alpha 1(IV) and alpha 2(IV) collagen ... "Entrez Gene: COL4A2 collagen, type IV, alpha 2". Hinek A (1995). "Nature and the multiple functions of the 67-kD elastin-/ ... Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another ...

https://en.wikipedia.org/wiki/Collagen,_type_IV,_alpha_2

Type I collagen Collagen, type III, alpha 1 Park KS, Park MJ, Cho ML, Kwok SK, Ju JH, Ko HJ, Park SH, Kim HY (2009). "Type II ... Type II collagen is organised into fibrils. This fibrillar network of collagen allows the cartilage to entrap the proteoglycan ... Collagen+type+II at the US National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short description ... Type II collagen is the basis for hyaline cartilage, including the articular cartilages at joint surfaces. It is formed by ...

https://en.wikipedia.org/wiki/Type_II_collagen

... types I, II, III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of ... Collagen, type I, alpha 1, also known as alpha-1 type I collagen, is a protein that in humans is encoded by the COL1A1 gene. ... the structure of type I collagen is compromised. Tissues that are rich in type I collagen, such as the skin, bones, and tendons ... Ehlers-Danlos type IV is most attributed to abnormalities in the reticular fibers (collagen Type III). Ehlers-Danlos syndrome, ...

https://en.wikipedia.org/wiki/Collagen,_type_I,_alpha_1

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations ... of type IV collagen in synovial capillaries by immunohistochemistry using a monoclonal antibody against human type IV collagen ... Collagen Type-IV collagen Alport syndrome GRCh38: Ensembl release 89: ENSG00000188153 - Ensembl, May 2017 GRCm38: Ensembl ... "Entrez Gene: COL4A5 collagen, type IV, alpha 5 (Alport syndrome)". Lemmink HH, Schröder CH, Monnens LA, Smeets HJ (1997). "The ...

https://en.wikipedia.org/wiki/Collagen,_type_IV,_alpha_5

This gene encodes the alpha chain of type XIX collagen, a member of the FACIT collagen family (fibril-associated collagens with ... other members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve ... collagen (COL12A1), alpha 1(IX) collagen (COL9A1), and alpha 1(XIX) collagen (COL19A1) to human chromosome 6q12-q13". Genomics ... "Entrez Gene: COL19A1 collagen, type XIX, alpha 1". Yoshioka H, Zhang H, Ramirez F, et al. (1992). "Synteny between the loci for ...

https://en.wikipedia.org/wiki/Collagen,_type_XIX,_alpha_1

"Entrez Gene: COL14A1 collagen, type XIV, alpha 1 (undulin)". "COL14A1 - Collagen alpha-1(XIV) chain precursor - Homo sapiens ( ... 2005). "Collagen types XII and XIV are present in basement membrane zones during human embryonic development". J. Mol. Histol. ... Tono-Oka S, Tanase S, Miike T, Tanaka H (1996). "Transient expression of collagen type XIV during muscle development and its ... Collagen alpha-1(XIV) chain is a protein that in humans is encoded by the COL14A1 gene. It likely plays a role in collagen ...

https://en.wikipedia.org/wiki/Collagen,_type_XIV,_alpha_1

Several types of catenins work with N-cadherins to play an important role in learning and memory. Cell-cell adhesion complexes ... Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR (October 2011). "A role for collagen XXIII in cancer cell ... For instance, higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened ... levels of collagen helped facilitate adhesions and anchorage-independent cell growth and provided evidence of collagen XXIII's ...

https://en.wikipedia.org/wiki/Catenin

Due to its many twists and turns, it is a common place for a type of horse colic called an impaction. The small colon is 3.0 to ... Once a tendon is damaged the tendon will always be weaker, because the collagen fibres tend to line up in random arrangements ... As tendons develop they lay down collagen, which is the main structural protein of connective tissue. As tendons pass near bony ... 295 (6): 1053-62. doi:10.1002/ar.22480. PMID 22539450. S2CID 26726269. McDonnell, Sue. "In Living Color." The Horse, Online ...

https://en.wikipedia.org/wiki/Equine_anatomy

Fluoride-containing toothpaste can be classified into two types, namely low-fluoride and high-fluoride toothpaste. Low-fluoride ... SDF, in addition to performing the functions of conventional topical fluorides, is suggested to have collagen-conserving ... Fluoride has a high tendency to react with the calcium hydroxyapatite Ca10(PO4)6(OH)2 in tooth enamel due to its high affinity ... 6 (2): 18. doi:10.3390/dj6020018. ISSN 2304-6767. PMC 6023524. PMID 29895726. Johnston, Nichole R.; Strobel, Scott A. (2020-04- ...

https://en.wikipedia.org/wiki/Topical_fluoride

... such as expression of several types of collagens and protein vimentin, a part of cytoskeletal filaments. Unlike fibroblasts, ... Fibroblast-like synoviocytes (FLS) represent a specialised cell type located inside joints in the synovium. These cells play a ... 2010). "Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production". Science. 327 (5965): 580- ... The inner layer is mainly composed of two cell types, specialized macrophages (macrophage-like synovial cells) and fibroblast- ...

https://en.wikipedia.org/wiki/Fibroblast-like_synoviocyte

"Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl ... is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous ... 7 (1): 10-6. doi:10.1038/sj.cdd.4400626. PMID 10713716. Era T (2002). "Bcr-Abl is a "molecular switch" for the decision for ... 469 (1): 72-6. doi:10.1016/S0014-5793(00)01242-4. PMID 10708759. Yano H, Cong F, Birge RB, Goff SP, Chao MV (February 2000). " ...

https://en.wikipedia.org/wiki/ABL_(gene)

While there may be some validity to the idea that for various types of specific damage detailed below that are by-products of ... Chemical damage to structural proteins can lead to loss of function; for example, damage to collagen of blood vessel walls can ... With respect to specific types of chemical damage caused by metabolism, it is suggested that damage to long-lived biopolymers, ... Horvath S (2013). "DNA methylation age of human tissues and cell types". Genome Biology. 14 (10): R115. doi:10.1186/gb-2013-14- ...

https://en.wikipedia.org/wiki/Senescence

The use of this type of product on a daily basis gradually enhances the exfoliation of the epidermis. This exposes newer skin ... Epidermal growth factor, to stimulate cell renewal and collagen production in the skin, and strengthen elasticity and structure ... showed that a proprietary blend of ingredients had a positive effect after six months of daily application when extrapolated to ... 6 (4): 182-183. doi:10.1111/j.1740-9713.2009.00395.x. "Drawing a line under men's wrinkles". BBC News Magazine. 2005-04-19. ...

https://en.wikipedia.org/wiki/Anti-aging_product

Excessive pronation of the foot (over 5 degrees) in the subtalar joint is a type of mechanical mechanism that can lead to ... This lack of blood supply can lead to the degradation of collagen fibers and inflammation. Tightness in the calf muscles has ... In those whose symptoms last more than six months despite other treatments, surgery may be considered. Achilles tendinitis is ... It is also a known side effect of fluoroquinolone antibiotics such as ciprofloxacin, as are other types of tendinitis. Swelling ...

https://en.wikipedia.org/wiki/Achilles_tendinitis

It is also unlikely that Paleolithic hunter-gatherers were affected by modern diseases of affluence such as type 2 diabetes, ... ISBN 978-0-521-44243-5. Six Degrees Could Change The World Mark Lynas interview. National Geographic Channel. {{cite AV media ... 19 February 2019). "Exceptionally high δ15N values in collagen single amino acids confirm Neandertals as high-trophic level ... For instance, archaeological evidence from art and bear remains reveals that the bear cult apparently involved a type of ...

https://en.wikipedia.org/wiki/Paleolithic

CDG syndrome type 1A CDG syndrome type 1B CDG syndrome type 1C CDG syndrome type 2 CDG syndrome type 3 CDG syndrome type 4 CDK4 ... hemolytic anemia Cold contact urticaria Cold urticaria Cole carpenter syndrome Coleman-Randall syndrome Colitis Collagen ... Tooth disease type 1C Charcot-Marie-Tooth disease type 2A Charcot-Marie-Tooth disease type 2B1 Charcot-Marie-Tooth disease type ... disease type 2C Charcot-Marie-Tooth disease type 2D Charcot-Marie-Tooth disease type 4A Charcot-Marie-Tooth disease type 4B ...

https://en.wikipedia.org/wiki/List_of_diseases_(C)

Shinohara ML, Kim J-H, Garcia VA, Cantor H. Engagement of the Type I interferon receptor on dendritic cells inhibits promotion ... Mobilization of natural killer cells inhibits development of collagen-induced arthritis. Proc Natl Acad Sci USA 2011;108:14584 ... an early component of type 1 (cell-mediated) immunity. Science 287: 860-864. †Panoutsakopoulou V, †Sanchirico ME, Huster KM, ... Nature Immunology 6:65-72. Shinohara ML, Lu L, Bu J, Werneck MBF, Kobayashi KS, Glimcher LH, Cantor H. Osteopontin expression ...

https://en.wikipedia.org/wiki/Harvey_Cantor

Tuberous sclerosis is also associated with a second type of angiofibroma, adenoma sebaceum, also termed facial angiofibroma, in ... spindle-shaped or star-shaped fibroblasts and ectatic blood vessels in a dense collagen fiber connective tissue background. In ... 32 (6): 413-8. doi:10.1111/j.0303-6987.2005.00358.x. PMID 15953374. S2CID 12366680. Zheng LQ, Huang Y, Han XC (May 2013). " ... 33 (6): 651-67. doi:10.1111/j.1524-4725.2007.33140.x. PMID 17550441. S2CID 41725531. Dzefi-Tettey K, Edzie EK, Gorleku P, ...

https://en.wikipedia.org/wiki/Koenen's_tumor

Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in ... integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. 276 (31): 29368-74. doi:10.1074/jbc. ... They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. ... Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells. The DX5 monoclonal ...

https://en.wikipedia.org/wiki/Integrin_alpha_2

There are two types of striated muscle: Cardiac muscle (heart muscle) Skeletal muscle (muscle attached to the skeleton) ... The perimysium organizes the muscle fibers, which are encased in collagen and endomysium, into fascicles. Each muscle fiber ... Based on their contractile and metabolic phenotypes, skeletal muscle can be classified as slow-oxidative (Type I) or fast- ... oxidative (Type II). Cardiac muscle lies between the epicardium and the endocardium in the heart. Cardiac muscle cells ...

https://en.wikipedia.org/wiki/Striated_muscle_tissue

The ISneck domain is a type of neck domain. There are two types of ISneck domain. This first is an ISneck which is interrupted ... Nummelin H, Merckel MC, Leo JC, Lankinen H, Skurnik M, Goldman A (2004). "The Yersinia adhesin YadA collagen-binding domain ... There are several types of head domain. Each domain helps the head to bind to a different component of the extracellular matrix ... There are two types of stalk domain: the FGG domain and the right-handed stalk domain. Structure: The structure of this protein ...

https://en.wikipedia.org/wiki/Trimeric_autotransporter_adhesin

Six men approached the bear, which woke up and attacked them. Four men shot the bear (with two bullets going through its lungs ... Protein sequencing of the material showed it to be collagen. In November 2010, hunter David Bradt stumbled on an elasmosaur ... There are four major types of habitat within the refuge: river bottom, riparian zones and wetlands, shoreline, and upland ( ... Lewis decided to call the creek near the spot where the six men almost died "Brown Bear Defeated Creek" (although today it is ...

https://en.wikipedia.org/wiki/Charles_M._Russell_National_Wildlife_Refuge

... mice made deficient in LECT2 using a gene knockout method developed more severe osteoarthritis induced by anti-type II collagen ... and other types of inflammation-related disorders; the metabolic syndrome and diabetes; and various types of liver disease. The ... Mice made deficient in the Lect2 gene were compared to wild-type mice in a model of high fatty acid diet-induced obesity and ... Several cell types or tissues, e.g. osteoblasts, chondrocytes, cardiac tissue, gastrointestinal smooth muscle cells, and ...

https://en.wikipedia.org/wiki/LECT2

At high temperatures, the rate of collagen loss will be accelerated and extreme pH can cause collagen swelling and accelerated ... The study of diagenesis in rocks is used to understand the geologic history they have undergone and the nature and type of ... During this phase, most bone collagen is lost and porosity is increased. The dissolution of the mineral phase caused by low pH ... Due to the increase in porosity of bones through collagen loss, the bone becomes susceptible to hydrolytic infiltration where ...

https://en.wikipedia.org/wiki/Diagenesis

This enzyme catalyses the following chemical reaction Hydrolysis of proteins including elastin, collagen types III and IV, ... 255 (8): 3482-6. PMID 6767718. Dreyfus LA, Iglewski BH (March 1986). "Purification and characterization of an extracellular ...

https://en.wikipedia.org/wiki/Pseudolysin

Collagen fibers have about a 4% elastic zone where fibers stretch out with increased load on the joint. However, exceeding this ... type of cold compress that is activated similarly to a blood pressure cuff) have been effective in reducing swelling and ... Ligaments are tough, inelastic fibers made of collagen that connect two or more bones to form a joint and are important for ... Chronic sprains are caused by repetitive movements leading to overuse.[citation needed] Ligaments are collagen fibers that ...

https://en.wikipedia.org/wiki/Sprain

The most widely used substance, gluteraldehyde crosslinked collagen (GAX collagen) proved to be of value in many patients. The ... This type of intervention can take a person months to learn and would not be a therapy option for people who are not physically ... There is no evidence that one type of incontinence pad is superior with regard to skin health. A pessary is a medical device ... Rortveit, G.; Hannestad, Y. S.; Daltveit, A. K.; Hunskaar, S. (December 2001). "Age- and type-dependent effects of parity on ...

https://en.wikipedia.org/wiki/Stress_incontinence

There are numerous types of liposuction. Some can be described as techniques or modalities. Often surgeons will use two or more ... Referred to as Smart Lipo, this technique uses laser technology to coagulate and tighten the skin and boost collagen ... Referred to as "a vibrating cannula" in research studies, PAL uses a specific type of wand that creates an up and down, ... Liposuction, or simply lipo, is a type of fat-removal procedure used in plastic surgery. Evidence does not support an effect on ...

https://en.wikipedia.org/wiki/Liposuction

... is a type of receptor which binds one or more signaling peptides or signaling proteins. An example ... Asprosin Bombesin Calcitonin Carnosine CART CLIP DSIP Enteroglucagon Formyl peptide GALP GIP GRP Integrin ligands collagens ...

https://en.wikipedia.org/wiki/Signaling_peptide_receptor

17 (4): 643-59, v-vi. doi:10.1016/S0749-0690(05)70091-4. PMID 11535421. Navasa M, Gordon DA, Hariharan N, Jamil H, Shigenaga JK ... "Glycated albumin stimulation of PKC-beta activity is linked to increased collagen IV in mesangial cells". The American Journal ... and angiotensin II-induced type 1 plasminogen activator inhibitor (PAI-1) gene expression in cultured human vascular smooth ... 20 (6): 669-76. doi:10.1038/sj.onc.1204137. PMID 11314000. Xie J, Pan H, Yoo S, Gao SJ (December 2005). "Kaposi's sarcoma- ...

https://en.wikipedia.org/wiki/AP-1_transcription_factor

There are various types of hepatocytes that are used in these devices. Porcine hepatocytes are often used due to ease of ... Hepatocytes are suspended in a gel solution such as collagen, which is injected into a series of hollow fibers. In the case of ... A liver support system or diachysis is a type of therapeutic device to assist in performing the functions of the liver. Such ... Basically, three different types of supportive therapies have been developed: bio-artificial, artificial and hybrid liver ...

https://en.wikipedia.org/wiki/Liver_support_system

... such as the Aquaflow collagen wick, ologen Collagen Matrix, or Xenoplast glaucoma implant. Laser-assisted NPDS is performed ... The most common type is open-angle (wide angle, chronic simple) glaucoma, in which the drainage angle for fluid within the eye ... A number of types of glaucoma surgeries may be used in people who do not respond sufficiently to other measures. Treatment of ... Since then, several types of implants have followed on from the original: the Baerveldt tube shunt, or the valved implants, ...

https://en.wikipedia.org/wiki/Glaucoma

Chernousov MA, Stahl RC, Carey DJ (1996). "Schwann cells secrete a novel collagen-like adhesive protein that binds N-syndecan ... this deactivated gene is found across many cancer types in this study to be the underlying cause of the disease. Tne CUX1 gene ... 15 (3): 695-6. doi:10.1006/geno.1993.1130. PMID 8468066. Glöckner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, ... 13 (6): 523-41. doi:10.3109/03630268908993104. PMID 2481658. Nepveu A (2001). "Role of the multifunctional CDP/Cut/Cux ...

https://en.wikipedia.org/wiki/CUTL1

Compared to Type I PEL, Type II PEL occurs more often in older individuals, is less often associated with EBV, and more often ... tightly woven collagen fibers) which forms around breast implants. Less frequently, individuals present with extracavitary ... than the malignant cells in Type I PEL. The response to treatment and prognosis of Type II PEL is poor but may be somewhat ... Type II PEL may be a less severe disease than Type I PEL, at lease in certain cases. PEL is generally resistant to cancer ...

https://en.wikipedia.org/wiki/Primary_effusion_lymphoma

"Establishing collagen quality criteria for sulphur isotope analysis of archaeological bone collagen". Archaeological and ... Six of these individuals had dental modifications similar to those carried out by peoples inhabiting tropical areas known to be ... Many methods tracking these types of changes have been developed using a variety of skeletal series. For instance, in children ... Though bone collagen is abundant in skeletal remains, less than 1% of the tissue is made of sulfur, making it imperative that ...

https://en.wikipedia.org/wiki/Bioarchaeology

In this study, an α2(VI) deficient mouse (Col6α2-KO) model was used to examine the role of Type VI collagen in oral tissues. ... The Role of Type VI Collagen in Alveolar Bone.. Komori, Taishi; Pham, Hai; Jani, Priyam; Perry, Sienna; Wang, Yan; Kilts, Tina ... In conclusion, Type VI collagen has a role in controlling biomineralization in alveolar bone and that changes in the ECM of ... Many studies have been conducted to elucidate the role of Type VI collagen in muscle and tendon, however, its role in oral ...

https://pesquisa.bvsalud.org/odontologia/resource/pt/mdl-36430826

Type XVII Collagen Regulates Lamellipod Stability, Cell Motility, and Signaling to Rac1 by Targeting Bullous Pemphigoid Antigen ... 1e to ?6?4 Integrin. Kevin J. Hamill, Susan B. Hopkinson, Marcel F. Jonkman, and Jonathan C. R. Jones The Feinberg School of ...

https://www.mattek.com/reference_library/type-xvii-collagen-regulates-lamellipod-stability-cell-motility-and-signaling-to-rac1-by-targeting-bullous-pemphigoid-antigen-1e-to-64-integrin/

... and nutritional contents for Ultra collagen type 1 &3 and over 2,000,000 other foods at MyFitnessPal ...

https://www.myfitnesspal.com/food/calories/ultra-collagen-type-1-3-1899728249

Collagen VI-related myopathy is a group of disorders that affect skeletal muscles and connective tissues. Explore symptoms, ... These genes each provide instructions for making one component of a protein called type VI collagen. Type VI collagen makes up ... and COL6A3 genes result in a decrease or lack of type VI collagen or the production of abnormal type VI collagen. While it is ... Collagen Type VI-Related Autosomal Dominant Limb-girdle Muscular Dystrophy *Genetic Testing Registry: Collagen 6-related ...

https://medlineplus.gov/genetics/condition/collagen-vi-related-myopathy/

Rabbit polyclonal Collagen IV antibody. Validated in WB, IP, ELISA, IHC, ICC/IF and tested in Mouse, Rat, Hamster, Cow, Dog, ... Negligible cross-reactivity with Type I, II, III, V or VI collagens. Non-specific cross reaction of anti-collagen antibodies ... Belongs to the type IV collagen family.. Contains 1 collagen IV NC1 (C-terminal non-collagenous) domain. ... Full length native protein (purified) corresponding to Collagen IV. Collagen Type IV from human and bovine placenta. The ...

https://www.abcam.com/products/primary-antibodies/collagen-iv-antibody-ab6586.html?

These disorders are the result of mutations in type IV collagen genes (see the image below). ... Evidence now suggests that accumulation of type V and VI collagen chains (along with alpha-1 [IV] and alpha-2 [IV] chains) in ... Type IV collagen is the major constituent of the GBM. Each type IV collagen molecule is composed of 3 subunits, called alpha ( ... arbitrarily is categorized as either the juvenile type or the adult type. The juvenile type is encountered in 75% of kindreds ...

https://emedicine.medscape.com/article/238260-overview

COL11A2: collagen, type XI, alpha 2(6p21.3). *CYP21A2: cytochrome P450, family 21, subfamily A, polypeptide 2 (6p21.33) ... This type of ideogram is generally used in genome browsers (e.g. Ensembl, UCSC Genome Browser). ... This type of ideogram represents actual relative band length observed under a microscope at the different moments during the ... G-bands of human chromosome 6 in resolution 850 bphs[19] Chr. Arm[20] Band[21] ISCN. start[22] ISCN. stop[22] Basepair. start ...

https://wikidoc.org/index.php/Chromosome_6

COL11A2: collagen, type XI, alpha 2. *CYP21A2: cytochrome P450, family 21, subfamily A, polypeptide 2 ... Ang Kromosomang 6 (Ingles: Chromosome 6) ang isa sa mga 23 pares ng mga kromosoma sa mga tao. Ang mga tao ay normal na may ... Ang kromosomang 6 ay sumasaklaw sa higit sa 170 milyong mga base na pares(na pantayong materyal ng DNA) at kumakatawa sa ... Ang kromosomang 6 ay malamang na naglalaman sa pagitan ng 2,000 at 2,057 na mga gene.[1] ...

https://tl.wikipedia.org/wiki/Kromosomang_6_

Expression of collagen, type I, alpha 1 (COL1A1) and osteopontin (OPN) at the end of the culture period in response to titanium ... Briefly, frozen aliquots of culture medium were thawed on ice and 65 µl used to conduct the measurements using the Vi-CELL ... Orthopedic Implants Market by Product Type, Biomaterial, and Type: Global Opportunity Analysis and Industry Forecast, 2018-2025 ... collagen type I alpha 1 (COL1A1), alkaline phosphatase liver/bone/kidney (ALPL), and osteopontin (OP) at the tissue-implant ...

https://www.nature.com/articles/s41598-020-78416-w?error=cookies_not_supported

Name: collagen, type I, alpha 2. Synonyms: Cola2, Cola-2, Col1a-2 ... Name: protein tyrosine phosphatase receptor type Q. Type: Gene ... When maintaining a live colony, heterozygous mice may be bred together, bred with wild-type siblings, or bred with C57BL/6J ... Name: ankyrin repeat and sterile alpha motif domain containing 6. Synonyms: LOC269533, Samd6, SamCystin, 2210417J20Rik, ...

https://www.mmrrc.org/catalog/sds.php?mmrrc_id=39746

Endostatin is derived from the noncollagenous domain 1 (NC1) at the C-terminus of collagen type XVIII. It inhibits endothelial ... Loss of collagen XVIII enhances neovascularization and vascular permeability in atherosclerosis. Circulation, 2004, 110(10): ... MMPs might cleave endostatin from collagen XVIII during sprouting angiogenesis, which contributes to endostatin increase in the ... American journal of reproductive immunology, 1997, 38:302-6.. *El-Salahy E et al. New scope in angiogenesis: Role of vascular ...

https://www.emro.who.int/ar/emhj-volume-12-2006/volume-12-issue-1-2/serum-endostatin-and-vascular-endothelial-growth-factor-levels-in-patients-with-pre-eclampsia.html

https://www.emro.who.int/emhj-volume-12-2006/volume-12-issue-1-2/serum-endostatin-and-vascular-endothelial-growth-factor-levels-in-patients-with-pre-eclampsia.html

... and collagen-glycosaminoglycan scaffold delays contraction and accelerates reepithelialization of dermal wounds in wild-type ... Herein, we examined the effect of the chemokine stromal cell-derived factor-1 (SDF-1) on the performance of a porous collagen- ... and Collagen-Glycosaminoglycan Scaffold Delays Contraction and Accelerates Reepithelialization of Dermal Wounds in Wild-Type ... 1 cm dorsal full-thickness wounds were covered with a collagen-glycosaminoglycan scaffold, followed by four daily topical ...

https://dash.harvard.edu/handle/1/32659609

These autoantibodies (anticitrullinated protein/peptide antibodies (ACPAs), rheumatoid factors (RF), anticollagen type II ... antibodies, antiglucose-6 phosphate isomerase antibodies, anticarbamylated protein antibodies, and antiacetylated protein ... J. S. Courtenay, M. J. Dallman, A. D. Dayan, A. Martin, and B. Mosedale, "Immunisation against heterologous type II collagen ... S. F. Amirahmadi, S. Whittingham, D. E. Crombie et al., "Arthritogenic anti-type II collagen antibodies are pathogenic for ...

https://www.hindawi.com/journals/mi/2019/6363086/

A second six-armed molecule resembled vertebrate tenascin and a third rod-like molecule resembled vertebrate collagen type IV. ... A second six-armed molecule resembled vertebrate tenascin and a third rod-like molecule resembled vertebrate collagen type IV. ...

https://ui.adsabs.harvard.edu/abs/1988RSPSB.235..247M/abstract

A portion of the hydrolysate was analyzed for hydroxyproline using high performance liquid chromatography with collagen type I ... Collagen concentration increased by five-fold and collagen cross-links by more than 7-fold consistent with fibrotic changes ... Analysis of hydroxyproline (collagen) and pyridinoline (collagen cross-links) in biopsies prepared for routine histological ... These techniques were adequate to analyze both collagen and pyridinoline (i.e. collagen cross-links) in small biopsy samples ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=%27ergonom%2A%27+or+musculoskeletal+or+repetitive+or+carpal&f1=TI&Startyear=&t1=1&s2=%27ergonom%2A%27+or+musculoskeletal+or+repetitive+or+carpal&terms=3&Adv=1&ct=&B1=Search&f2=KW&Limit=500&Sort=DP+DESC&D1=10&EndYear=&PageNo=348&RecNo=3475&View=f&

... carry a mutation that prevents them from making type VII collagen. The babies suffer wounds and excessive bleeding and tend to ... Young Adults With Type 2 Diabetes: A Journey Begins: When Baby Changes Everything ... receive a quick diagnosis within the first 6 months of life, according to Andy Orth, chief commercial officer at Krystal Bio, ...

https://www.medscape.com/viewarticle/994475

Intratracheal administration of 100 micrograms of rhHGF to C57BL/6 mice led to prolifera … ... Publication types * Research Support, U.S. Govt, P.H.S. MeSH terms * Analysis of Variance ... Hepatocyte growth factor attenuates collagen accumulation in a murine model of pulmonary fibrosis Am J Respir Crit Care Med. ... We found that HGF significantly attenuated collagen accumulation induced by bleomycin as determined by quantitation of ...

https://pubmed.ncbi.nlm.nih.gov/11112155/?dopt=Abstract

https://reference.medscape.com/article/238260-overview

Collagen is the protein that gives your skin its structure and elasticity. Loss of collagen is one of the main causes of aging ... PDO threads are one of three types of sutures commonly used in thread lift procedures. The other two types are made from ... Other types of threads. PLA and PCA threads are newer than PDO. They last longer in your body and tend to stimulate more ... Each type of thread is best suited for a particular function. PDO threads are better at repositing and revitalizing tissue ...

https://www.healthline.com/health/beauty-skin-care/pdo-thread-lift

In the other patient with collagenous sprue (CoS2), subepithelial collagen deposition reached a thickness of 50 μm. In the ... In addition, biopsies from six consecutive patients with refractory sprue of uncertain cause were examined. ... enteropathy-type intestinal T cell lymphoma. IELs. intraepithelial T lymphocytes. non-EITCL. non-enteropathy-type intestinal T ... enteropathy-type intestinal T cell lymphoma. IELs. intraepithelial T lymphocytes. non-EITCL. non-enteropathy-type intestinal T ...

https://gut.bmj.com/content/49/6/804

Another six (undenatured type II collagen, avocado soybean unsaponifiables, methylsulfonylmethane, diacerein, glucosamine and ... Another six (avocado soybean unsaponifiables, undenatured type II collagen, methylsulfonylmethane (MSM), diacerein, glucosamine ... Only green-lipped mussel extract and undenatured type II collagen had clinically important effects on pain at medium term. No ... Five supplements (undenatured type II collagen, avocado/soybean unsaponifiables (ASU), glucosamine, chondroitin and diacerein) ...

https://bjsm.bmj.com/content/52/3/167.long?fbclid=IwAR3UxYwkc6msS1w17c_52MnW89CsO9R_GaiXvIL2b00RD6lvTJ7Rdc1lNQA

Collagen Type I Alpha 2 Chain (COL1A2), Galectin 4 (LGALS4) and Tetraspanin 8 (TSPAN8) mRNAs as blood biomarkers for colorectal ...

https://www.unibo.it/sitoweb/enea.ferlizza2/publications

Okyar A, Can A, Akev N, Baktir G, Sutlupinar N , "Effect of Aloe vera leaves on blood glucose level in type I and type II ... Chithra P, Sajithlal GB, Chandrakasan G., "Influence of Aloe vera on collagen characteristics in healing dermal wounds in rats ... 1998 Apr;181(1-2):71-6. Schmidt JM, Greenspoon JS, "Aloe vera dermal wound gel is associated with a delay in wound healing." ... 2000 Jun;14(4):261-6.. *Akai R. (1989) Epidemiologic survey on lung cancer with respect to cigarette smoking and plant diet. ...

https://www.life-enthusiast.com/articles/benefits-of-aloe-vera/

... collagen, or spider silk boast unusual combinations of stiffness, strength, and toughness. Behind this performance is the ... Natural materials such as nacre, bone, collagen, or spider silk boast unusual combinations of stiffness, strength, and ... the smallest representative volume for this type of material. However, these mechanisms only translate to high performance if ... Natural materials such as nacre, bone, collagen, or spider silk boast unusual combinations of stiffness, strength, and ...

https://docs.lib.purdue.edu/ses2014/bio/compexp/6/

Collagen deposition limits immune reconstitution in the gut. J Infect Dis. 2008;198(4):456-464.. View this article via: PubMed ... Biopsies of the lesion return moderately differentiated adenocarcinoma that is wild type for the KRAS mutation by real-time PCR ... Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte ... 6 Michael D. Miller,7 Michael M. Lederman,3 Julie A. Segre,5 Jeffrey D. Lifson,4 Elias K. Haddad,2 Jacob D. Estes,4 and Jason M ...

https://www.jci.org/articles/view/66227?key=1cff041937d9040dfed7

Medical Hydrolysate of Type I Collagen.. *Collasate Spray ingredients: Medical Hydrolysate of Type I Collagen, Bitrex, and ... All Collasate products contain Medical Hydrolysate of Type 1 Collagen.. *Unlike other collagen products, which are made from ... Collasate Silver ingredients: Medical Hydrolysate of Type I Collagen, 1% Silver Oxide. ... native collagen, Collasates hydrolyzed collagen is a patented product available in amino acid form to be immediately utilized ...

https://vetrxdirect.com/product/view/collasate-for-dogs-and-cats-otc

7, P = 0.0276). Six-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health. Acceleration ... The primary outcomes were changes in anthropometric measurements and biochemical indexes from baseline to 6 months after ... or a placebo in 100 ml liquid/day were ingested for 6 months. ... N-telopeptides of type I collagen. 8-OHdG:. 8-hydroxy-2- ... N-telopeptides of type I collagen (NTx) and ratio of urinary 8-hydroxy-2-deoxyguanosine (8-OHdG) to creatinine. Plasma and ...

https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-11-77

Variants (also known as mutations) in the COL6A1 , COL6A2 , and COL6A3 genes can cause the various forms of collagen VI-related dystrophy. (medlineplus.gov)
Patients with recessive dystrophic epidermolysis bullosa (RDEB) have incurable skin fragility, blistering, and skin wounds due to mutations in the gene that codes for type VII collagen (C7) that mediates dermal-epidermal adherence in human skin. (nih.gov)
Mutations in these genes result in abnormalities of the type IV collagen in glomeruli, which prevents the kidneys from properly filtering the blood and allows blood and protein to pass into the urine. (nih.gov)
Mutations that disrupt type IV collagen can result in misshapen lenses and an abnormally colored retina. (nih.gov)
Certain gene changes, or mutations, cause the collagen defects. (nih.gov)
About 80%-90% of OI cases are caused by autosomal dominant mutations in the type 1 collagen genes, COL1A1 and COL1A2 . (nih.gov)
Mutations in one or the other of these genes cause the body to make either abnormally formed collagen or too little collagen. (nih.gov)
Mutations in these genes cause OI Types I through IV. (nih.gov)
The remaining cases of OI (types VI-XI) are caused by autosomal recessive mutations in any of six genes ( SERPINF1, CRTAP, LEPRE1, PPIB, SERPINH1, and FKBP10 ) that code for proteins that help make collagen. (nih.gov)
These mutations also cause the body to make too little collagen or abnormally formed collagen. (nih.gov)

This invention includes the identification of a new mutation in the collagen type VI (COL6A1) gene, including a method for diagnosing and treating patients with this mutation. (nih.gov)
Our novel identification includes a mutation in intron 11 of the COL6A1 gene that alters the splicing of the gene pre-mRNA and produces a mature alpha 1 (VI) chain mRNA that comprises an additional exon. (nih.gov)
The human leukocyte antigen lies on chromosome 6, with the exception of the gene for β2-microglobulin (which is located on chromosome 15 ), and encodes cell-surface antigen -presenting proteins among other functions. (wikidoc.org)
Ang kromosomang 6 ay malamang na naglalaman sa pagitan ng 2,000 at 2,057 na mga gene. (wikipedia.org)
BACKGROUND Clonal T cell receptor (TCR) gene rearrangements and loss of T cell antigens such as CD8 and TCR-β in intraepithelial lymphocytes (IELs) may indicate the development of an enteropathy-type intestinal T cell lymphoma (EITCL) in patients with refractory sprue. (bmj.com)
RESULTS Clonal TCR-γ gene rearrangements were found in all resected tumours of patients with EITCL, in 3/8 duodenal biopsies of patients with EITCL, in 2/2 patients with ulcerative jejunitis, in 2/3 patients with refractory sprue evolving into overt EITCL, and in 1/6 patients with refractory sprue. (bmj.com)

Intratracheal administration of 100 micrograms of rhHGF to C57BL/6 mice led to proliferation of bronchial and alveolar epithelial cells as indicated by an increased number of cells staining for proliferating cell nuclear antigen (PCNA). (nih.gov)

Moreover, diabetic renal ECM shows diminished binding of α1β1 integrin consistent with the modification of collagen IV by hypochlorous (HOCl) and hypobromous acids. (diabetesjournals.org)

Human chromosome 6 pair after G-banding . (wikidoc.org)
Chromosome 6 pair in human male karyogram . (wikidoc.org)
Chromosome 6 is one of the 23 pairs of chromosomes in humans . (wikidoc.org)
Chromosome 6 spans more than 170 million base pairs (the building material of DNA ) and represents between 5.5 and 6% of the total DNA in cells . (wikidoc.org)
In 2003, the entirety of chromosome 6 was manually annotated for proteins, resulting in the identification of 1,557 genes, and 633 pseudogenes . (wikidoc.org)
The following is a partial list of genes on human chromosome 6. (wikidoc.org)
Chromosome 6 ) ang isa sa mga 23 pares ng mga kromosoma sa mga tao . (wikipedia.org)

The defect in the genes causes the body to make collagen incorrectly or not make enough, leading to weak bones that break more easily. (nih.gov)

Collagen type VI-related dystrophies (COL6-RD) are devastating neuromuscular disorders that manifest with progressive generalized muscle weakness, contractures, and respiratory failure. (nih.gov)
Collagen 6-related dystrophies and myopathies (COL6-RD) are a group of disorders that form a wide phenotypic spectrum, ranging from severe Ullrich congenital muscular dystrophy, intermediate phenotypes, to the milder Bethlem myopathy. (ru.nl)

A portion of the hydrolysate was analyzed for hydroxyproline using high performance liquid chromatography with collagen type I as the standard. (cdc.gov)
All Collasate products contain Medical Hydrolysate of Type 1 Collagen. (vetrxdirect.com)
Collasate Postoperative Dressing ingredients: Medical Hydrolysate of Type I Collagen. (vetrxdirect.com)
Collasate Spray ingredients: Medical Hydrolysate of Type I Collagen, Bitrex, and collascent. (vetrxdirect.com)
Collasate Silver ingredients: Medical Hydrolysate of Type I Collagen, 1% Silver Oxide. (vetrxdirect.com)

C57BL/6 mice with 1 cm × 1 cm dorsal full-thickness wounds were covered with a collagen-glycosaminoglycan scaffold, followed by four daily topical applications of 1 μg SDF-1 or phosphate-buffered saline vehicle. (harvard.edu)

Type VI collagen makes up part of the extracellular matrix that surrounds muscle cells and connective tissue. (medlineplus.gov)
Research suggests that type VI collagen helps secure and organize the extracellular matrix by linking the matrix to the cells it surrounds. (medlineplus.gov)
Changes in type VI collagen structure or production lead to an unstable extracellular matrix that is no longer attached to cells. (medlineplus.gov)
Non-specific cross reaction of anti-collagen antibodies with other human serum proteins or non-collagen extracellular matrix proteins is negligible. (abcam.com)
Immunoaffinity chromatography using immobilized antigens followed by extensive cross-adsorption against other collagens, human serum proteins and non-collagen extracellular matrix proteins to remove any unwanted specificities. (abcam.com)
Mature human SCARA5 consists of a 60 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 414 aa extracellular domain (ECD) with a spacer, a collagen-like, and a scavenger receptor cysteine-rich (SRCR) domain (4-6). (rndsystems.com)

Collagen VI (COL6) is known for its role in a spectrum of congenital muscular dystrophies, which are often accompanied by respiratory dysfunction. (nih.gov)

These genes each provide instructions for making one component of a protein called type VI collagen. (medlineplus.gov)
Variants in the COL6A1 , COL6A2 , and COL6A3 genes result in a decrease or lack of type VI collagen or the production of abnormal type VI collagen. (medlineplus.gov)
For most people, a change or defect in the genes that carry the instructions for making type I collagen causes OI. (nih.gov)

Epub 2016 Dec 6. (nih.gov)

OI is caused by defects in or related to a protein called type 1 collagen. (nih.gov)

Collagen VI Deficiency Results in Structural Abnormalities in the Mouse Lung. (nih.gov)
These airspace abnormalities included reduced isolectin B4+ alveolar capillaries and surfactant protein C-positive alveolar epithelial type-II cells. (nih.gov)

We found that HGF significantly attenuated collagen accumulation induced by bleomycin as determined by quantitation of hydroxyproline content and by scoring of the extent of fibrosis. (nih.gov)
Analysis of hydroxyproline (collagen) and pyridinoline (collagen cross-links) in biopsies prepared for routine histological evaluation with OCT compound was performed. (cdc.gov)

Chondroitin sulfate is likely safe when used for up to 6 years. (nih.gov)
Another six (undenatured type II collagen, avocado soybean unsaponifiables, methylsulfonylmethane, diacerein, glucosamine and chondroitin) revealed statistically significant improvements on pain, but were of unclear clinical importance. (bmj.com)

Parental mosaicism was confirmed in the four families through quantitative analysis of the ratio of mutant versus wild-type allele (COL6A1, COL6A2, and COL6A3) in genomic DNA from various tissues, including blood, dermal fibroblasts, and saliva. (ru.nl)

These autoantibodies (anticitrullinated protein/peptide antibodies (ACPAs), rheumatoid factors (RF), anticollagen type II antibodies, antiglucose-6 phosphate isomerase antibodies, anticarbamylated protein antibodies, and antiacetylated protein antibodies) have different characteristics, diagnostic/prognostic value, and pathological significance in RA patients. (hindawi.com)

There are other recombinant monoclonal options, such as Recombinant Anti-Collagen IV antibody . (abcam.com)

ab6586 is designed to bind specifically to NATIVE collagen epitopes composed of multiple subunit strands. (abcam.com)

Class A scavenger receptors, including CL-P1, MARCO, SCARA3, and SR-A1, are type II transmembrane proteins that contain a collagenous stalk (1-3). (rndsystems.com)

These were accompanied by the reduced expression of connective tissue growth factor, fewer α smooth muscle actin (α-SMA)-positive myofibroblasts, and less deposition of collagen in the healed neodermis, consistent with less scar formation. (nih.gov)
Collagen concentration increased by five-fold and collagen cross-links by more than 7-fold consistent with fibrotic changes known to occur with denervation. (cdc.gov)
Consistent with somatic mosaicism, parental samples had lower ratios of mutant versus wild-type allele compared with the fully heterozygote offspring. (ru.nl)

The Role of Type VI Collagen in Alveolar Bone. (bvsalud.org)
In conclusion, Type VI collagen has a role in controlling biomineralization in alveolar bone and that changes in the ECM of alveolar bone could be associated with greater bone loss due to periodontitis . (bvsalud.org)

Only green-lipped mussel extract and undenatured type II collagen had clinically important effects on pain at medium term. (bmj.com)
Clinically similar to Type IV OI in appearance and symptoms. (nih.gov)

1996) Evaluation of different chemical methods for cros-linking collagen gel, films and sponges. (aimspress.com)

Structure and multiple conformations of the Kunitz-type domain from human type VI collagen alpha 3(VI) chain in solution. (nih.gov)
The compaction of collagen films, mediated by the drying and cross-linking fabrication process, suggests a less open organization compared to native fibrillar collagen that likely allowed the collagen to form more inter-chain bonds and chemical links with NDGA polymers. (aimspress.com)

In addition, biopsies from six consecutive patients with refractory sprue of uncertain cause were examined. (bmj.com)

These techniques were adequate to analyze both collagen and pyridinoline (i.e. collagen cross-links) in small biopsy samples ( (cdc.gov)
Blood may also be collected to measure a type of collagen that indicates new bone formation and to analyze DNA for genetic studies. (nih.gov)

6. Type IV collagen induces STAT5 activation in MCF7 human breast cancer cells. (nih.gov)
The presence of these sutures in your skin triggers cells in your body called fibroblasts to produce more collagen . (healthline.com)

The body uses type 1 collagen to make bones strong and to build tendons, ligaments, teeth, and the whites of the eyes. (nih.gov)
Type I collagen is a material in bones that helps make them strong. (nih.gov)

Herein, we examined the effect of the chemokine stromal cell-derived factor-1 (SDF-1) on the performance of a porous collagen-glycosaminoglycan dermal analog in excisional wounds in mice. (harvard.edu)
The effect of HGF on the lung repair process was examined by administration of 100 micrograms of rhHGF on Day 3 and Day 6 after intratracheal injection of bleomycin to mice. (nih.gov)

Endostatin is derived from the noncollagenous domain 1 (NC1) at the C-terminus of collagen type XVIII. (who.int)
Noncollagenous (NC1) hexamers, key connection modules of collagen IV networks, are modified via oxidation and chlorination of tryptophan and bromination of tyrosine residues. (diabetesjournals.org)

Nous avons déterminé la concentration d'endostatine et de VEGF dans le sérum de 20 femmes non enceintes en bonne santé et de 64 femmes enceintes : 20 en bonne santé, 20 ayant une prééclampsie bénigne et 24 une prééclampsie grave. (who.int)
La concentration sérique pour ces facteurs chez les femmes non enceintes était similaire à celle des femmes enceintes en bonne santé. (who.int)
Toutefois, la concentration sérique était significativement plus élevée en présence d'une prééclampsie bénigne ou grave par rapport aux grossesses normales et significativement plus élevée pour les prééclampsies graves par rapport aux prééclampsies bénignes. (who.int)

Wound Repair and Regeneration 19 (1) (December 6): 71-79. (harvard.edu)
Unlike other collagen products, which are made from native collagen, Collasate's hydrolyzed collagen is a patented product available in amino acid form to be immediately utilized by the wound site for healing, helping speed recovery. (vetrxdirect.com)

However, there was a noticeable decline in results 6 months later. (healthline.com)
Most severe type among those who survive the neonatal period and usually results in the greatest number of physical disabilities. (nih.gov)
Our results suggest that hypohalous acid-derived modifications of renal ECM, and specifically collagen IV networks, contribute to functional protein damage in diabetes. (diabetesjournals.org)

Researchers have described several forms of collagen VI-related dystrophy, which range in severity: Bethlem muscular dystrophy is the mildest, an intermediate form is moderate in severity, and Ullrich congenital muscular dystrophy is the most severe. (medlineplus.gov)
While it is difficult to predict which type of variant will lead to which form of collagen VI-related dystrophy, in general, lower amounts of type VI collagen lead to more severe signs and symptoms that begin earlier in life. (medlineplus.gov)
Type II is the most severe form of OI. (nih.gov)

Collagen concentrations ranged from 6.6 microg/mg dry weight (liver) to 74.7 microg/mg dry weight (diaphragm). (cdc.gov)

Many studies have been conducted to elucidate the role of Type VI collagen in muscle and tendon , however, its role in oral tissues remains unclear. (bvsalud.org)
Fixation is required to reinforce reconstituted collagen for orthopedic bioprostheses such as tendon or ligament replacements. (aimspress.com)
Type I collagen is also in other connective tissues such as tendon, ligament, lung, and skin, and these tissues can sometimes be affected. (nih.gov)

Collagen Type IV from human and bovine placenta. (abcam.com)

Six-month ingestion of RJ in humans improved erythropoiesis, glucose tolerance and mental health. (biomedcentral.com)

Collagen is the protein that gives your skin its structure and elasticity. (healthline.com)
Normal collagen structure, but less than the normal amount is produced. (nih.gov)

Effect of nordihydroguaiaretic acid cross-linking on fibrillar collagen: in vitro evaluation of fibroblast adhesion strength and migration[J]. AIMS Bioengineering, 2017, 4(2): 300-317. (aimspress.com)

The intermediate form of collagen VI-related dystrophy is characterized by muscle weakness that begins in infancy. (medlineplus.gov)
Type I is the mildest and most common form of OI. (nih.gov)
Medical grade gel form of collagen. (vetrxdirect.com)

Enteropathy-type intestinal T cell lymphoma (EITCL) is a complication of longstanding and untreated coeliac disease. (bmj.com)

Alternate splicing generates isoforms that lack the SRCR domain, the transmembrane segment, or the 225 aa spacer region between the membrane and the collagen-like domain (6). (rndsystems.com)

This work focuses on investigating fibroblast behavior on fibrillar and NDGA cross-linked type I collagen to determine if NDGA modulates cell adhesion, morphology, and migration. (aimspress.com)

Alterations in type IV collagen often result in abnormal inner ear function, which can lead to hearing loss. (nih.gov)
its loss enhances angioge-nesis and vascular permeability [6]. (who.int)
Loss of collagen is one of the main causes of aging skin. (healthline.com)

Smooth sutures that help rejuvenate your skin by stimulating collagen production. (healthline.com)
They last longer in your body and tend to stimulate more collagen production. (healthline.com)

Anatomy6

Diseases2

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes1

Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M. (1/145)

Flexibility and packing in proteins. (2/145)

Differential gene expression in human abdominal aorta: aneurysmal versus occlusive disease. (3/145)

Antibody response against perlecan and collagen types IV and VI in chronic renal allograft rejection in the rat. (4/145)

The influence of the pericellular microenvironment on the chondrocyte response to osmotic challenge. (5/145)

Mutations in COL6A3 cause severe and mild phenotypes of Ullrich congenital muscular dystrophy. (6/145)

Isolation of up- or down-regulated genes in PPARgamma-expressing NIH-3T3 cells during differentiation into adipocytes. (7/145)

Identification of known and novel genes whose expression is regulated by endogenous retinoic acid during early embryonic development of the mouse. (8/145)

Collagen Type VI

Collagen

Extracellular Matrix Proteins

Collagen Type I

Immunoblotting

Collagen Type III

Collagen Type IV

Collagen Type II

Collagen Type V

Fibrillar Collagens

Bacterial Secretion Systems

Mucopolysaccharidosis VI

Collagen Type XI

Extracellular Matrix

Receptors, Collagen

N-Acetylgalactosamine-4-Sulfatase

Pepsin A

Fibroblasts

Glycogen Storage Disease Type VI

Cartilage

Collagen Type XVIII

Procollagen

Fibronectins

Cells, Cultured

Collagen Type X

Basement Membrane

Collagen Type XII

Decorin

Cartilage, Articular

Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M. (1/145)

Flexibility and packing in proteins. (2/145)

Differential gene expression in human abdominal aorta: aneurysmal versus occlusive disease. (3/145)

Antibody response against perlecan and collagen types IV and VI in chronic renal allograft rejection in the rat. (4/145)

The influence of the pericellular microenvironment on the chondrocyte response to osmotic challenge. (5/145)

Mutations in COL6A3 cause severe and mild phenotypes of Ullrich congenital muscular dystrophy. (6/145)

Isolation of up- or down-regulated genes in PPARgamma-expressing NIH-3T3 cells during differentiation into adipocytes. (7/145)

Identification of known and novel genes whose expression is regulated by endogenous retinoic acid during early embryonic development of the mouse. (8/145)

Collagen, type VI, alpha 1

Collagen, type VI, alpha 3

Collagen, type VI, alpha 2

Collagen, type VI, alpha 5

Collagen, type IV, alpha 6

Collagen VI

Collagen, type XV, alpha 1

Collagen, type VII, alpha 1

Collagen, type XI, alpha 1

Collagen, type XXVIII, alpha 1

Collagen, type II, alpha 1

Collagen, type IV, alpha 1

Collagen, type XII, alpha 1

Collagen, type XVI, alpha 1

Collagen, type I, alpha 2

Collagen loss

Collagen, type IX, alpha 3

Collagen, type IX, alpha 1

Collagen, type IX, alpha 2

Collagen, type XXIII, alpha 1

Collagen, type VIII, alpha 1

Collagen, type XIII, alpha 1

Collagen, type XXVII, alpha 1

Collagen, type V, alpha 3

Collagen, type IV, alpha 2

Type II collagen

Collagen, type I, alpha 1

Collagen, type IV, alpha 5

Collagen, type XIX, alpha 1

Collagen, type XIV, alpha 1

Catenin

Equine anatomy

Topical fluoride

Fibroblast-like synoviocyte

ABL (gene)

Senescence

Anti-aging product

Achilles tendinitis

Paleolithic

List of diseases (C)

Harvey Cantor

Koenen's tumor

Integrin alpha 2