Collagen Type V: A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Collagen Type III: A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.Anti-Glomerular Basement Membrane Disease: An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Basement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Collagen Type IV: A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.Hearing Loss, Sensorineural: Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM.Hemoptysis: Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.Collagen Type VII: A non-fibrillar collagen involved in anchoring the epidermal BASEMENT MEMBRANE to underlying tissue. It is a homotrimer comprised of C-terminal and N-terminal globular domains connected by a central triple-helical region.Epidermolysis Bullosa Acquisita: Form of epidermolysis bullosa characterized by trauma-induced, subepidermal blistering with no family history of the disease. Direct immunofluorescence shows IMMUNOGLOBULIN G deposited at the dermo-epidermal junction.Epidermolysis Bullosa Dystrophica: Form of epidermolysis bullosa characterized by atrophy of blistered areas, severe scarring, and nail changes. It is most often present at birth or in early infancy and occurs in both autosomal dominant and recessive forms. All forms of dystrophic epidermolysis bullosa result from mutations in COLLAGEN TYPE VII, a major component fibrils of BASEMENT MEMBRANE and EPIDERMIS.Epidermolysis Bullosa: Group of genetically determined disorders characterized by the blistering of skin and mucosae. There are four major forms: acquired, simple, junctional, and dystrophic. Each of the latter three has several varieties.Blister: Visible accumulations of fluid within or beneath the epidermis.Protein Processing, Post-Translational: Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.Body Temperature: The measure of the level of heat of a human or animal.Molecular Chaperones: A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. Although they take part in the assembly process, molecular chaperones are not components of the final structures.Proteostasis Deficiencies: Disorders caused by imbalances in the protein homeostasis network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins.Endoplasmic Reticulum: A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Collagen Type II: A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.Reward: An object or a situation that can serve to reinforce a response, to satisfy a motive, or to afford pleasure.Drug Approval: Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.Collagen Type XVIII: A non-fibrillar collagen found in BASEMENT MEMBRANE. The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage.Endostatins: Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.Descemet Membrane: A layer of the cornea. It is the basal lamina of the CORNEAL ENDOTHELIUM (from which it is secreted) separating it from the CORNEAL STROMA. It is a homogeneous structure composed of fine collagenous filaments, and slowly increases in thickness with age.Wnt2 Protein: A proto-oncogene protein and member of the Wnt family of proteins. It is frequently up-regulated in human GASTRIC CANCER and is a tumor marker (BIOMARKERS, TUMOR) of gastric and COLORECTAL CANCER.Renin-Angiotensin System: A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.Enalapril: An angiotensin-converting enzyme inhibitor that is used to treat HYPERTENSION and HEART FAILURE.Kidney Failure, Chronic: The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.CreatinineRenal Dialysis: Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.Hyaluronic Acid: A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.Dietary Supplements: Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.Capsules: Hard or soft soluble containers used for the oral administration of medicine.Chondrocytes: Polymorphic cells that form cartilage.Cartilage: A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.Elastic Cartilage: A type of CARTILAGE whose matrix contains ELASTIC FIBERS and elastic lamellae, in addition to the normal components of HYALINE CARTILAGE matrix. Elastic cartilage is found in the EXTERNAL EAR; EUSTACHIAN TUBE; EPIGLOTTIS; and LARYNX.Cartilage, Articular: A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.Extracellular Matrix Proteins: Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Poultry: Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.Erythrocytes: Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.Foot: The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.Plasmapheresis: Procedure whereby plasma is separated and extracted from anticoagulated whole blood and the red cells retransfused to the donor. Plasmapheresis is also employed for therapeutic use.Kidney Glomerulus: A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.

Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases. (1/105)

The low abundance fibrillar collagen type V is incorporated into and regulates the diameters of type I collagen fibrils. Bone morphogenetic protein-1 (BMP-1) is a metalloprotease that plays key roles in regulating formation of vertebrate extracellular matrix; it cleaves the C-propeptides of the major fibrillar procollagens I-III and processes precursors to produce the mature forms of the cross-linking enzyme prolysyl oxidase, the proteoglycan biglycan, and the basement membrane protein laminin 5. Here we have successfully produced recombinant pro-alpha1(V)(2)pro-alpha2(V) heterotrimers, and we have used these to characterize biosynthetic processing of the most prevalent in vivo form of type V procollagen. In addition, we have compared the processing of endogenous pro-alpha1(V) chains by wild type mouse embryo fibroblasts and by fibroblasts derived from embryos doubly homozygous null for the Bmp-1 gene and for a gene encoding the closely related metalloprotease mammalian Tolloid-like 1. Together, results presented herein indicate that within pro-alpha1(V)(2)pro-alpha2(V) heterotrimers, pro-alpha1(V) N-propeptides and pro-alpha2(V) C-propeptides are processed by BMP-1-like enzymes, and pro-alpha1(V) C-propeptides are processed by furin-like proprotein convertases in vivo.  (+info)

Schwann cell adhesion to a novel heparan sulfate binding site in the N-terminal domain of alpha 4 type V collagen is mediated by syndecan-3. (2/105)

Previously we reported that type V collagen synthesized by Schwann cells inhibits the outgrowth of axons from rat embryo dorsal root ganglion neurons but promotes Schwann cell migration (Chernousov, M. A., Stahl, R. C., and Carey, D. J. (2001) J. Neurosci. 21, 6125-6135). Analysis of Schwann cell adhesion and spreading on dishes coated with various type V collagen domains revealed that Schwann cells adhered effectively only to the non-collagenous N-terminal domain (NTD) of the alpha4(V) collagen chain. Schwann cell adhesion to alpha4(V)-NTD induced actin cytoskeleton assembly, tyrosine phosphorylation, and activation of the Erk1/Erk2 protein kinases. Adhesion to alpha4(V)-NTD is cell type-specific because rat fibroblasts failed to adhere to dishes coated with this polypeptide. Schwann cell adhesion and spreading on alpha4(V)-NTD was strongly inhibited by soluble heparin (IC(50) approximately 30 ng/ml) but not by chondroitin sulfate. Analysis of the heparin binding activities of a series of recombinant alpha4(V)-NTD fragments and deletion mutants identified a highly basic region (not present in other type V collagen NTD) as the site responsible for high affinity heparin binding. Schwann cells adhered poorly to dishes coated with alpha4(V)-NTD that lacked the heparin binding site and failed to spread or assemble organized actin-cytoskeletal structures. Soluble alpha4(V)-NTD polypeptide that contained the heparin binding site inhibited spreading of Schwann cells on dishes coated with alpha4(V)-NTD. Affinity chromatography of Schwann cell detergent extracts on a column of immobilized alpha4(V)-NTD resulted in the isolation of syndecan-3, a transmembrane heparan sulfate proteoglycan. Together, these results suggest that Schwann cells bind to collagen type V via syndecan-3-dependent binding to a novel high affinity heparin binding site in the alpha4(V)-NTD.  (+info)

Type V collagen distribution in liver is reconstructed in coculture system of hepatocytes and stellate cells; the possible functions of type V collagen in liver under normal and pathological conditions. (3/105)

The contents of type I, type III and type V collagen and the collagen type specific distributions in liver under normal and cirrhotic conditions were examined. In CCl4 injected rat, the increasing amount of type V collagen was a specific event during the progression of cirrhosis. In normal liver, immunohistochemical observation showed that type V collagen was localized on the fine fibrils, while type I was localized on the thick fibril. Type V collagen was partially colocalized with type IV collagen. In the cirrhotic liver, type V collagen was localized on the margin of the thick fibrous septa along with type IV collagen. Type I collagen existed in the core region of fibrous septa where the stellate cells were prominent. To elucidate the mechanism of the type specific deposition of collagen in the liver, we constructed a coculture system using both stellate cells and hepatocytes. In this system, type V collagen was mainly deposited on hepatocyte colonies not on stellate cells, while type I collagen fibrils were localized on stellate cells. The spatial positioning of type I and type V collagens in vitro was similar to that in the liver. In the cell adhesion assay, the adhesion of stellate cells to type V collagen was poorer than that of the hepatocytes. The collagen type-specific affinity of the stellate cells and hepatocytes may explain the specific localization of type V collagen in the liver and coculture system. These results suggested that the functions of type V collagen are not only to connect type IV collagen with type I collagen fibril, but also to protect the parenchyma from excess type I collagen deposition produced by stellate cells under pathological conditions.  (+info)

Evidence for immune responses to a self-antigen in lung transplantation: role of type V collagen-specific T cells in the pathogenesis of lung allograft rejection. (4/105)

We have reported that lung allograft rejection involves an immune response to a native protein in the lung, type V collagen (col(V)), and that col(V)-induced oral tolerance prevented acute and chronic rejection. In support of these findings col(V) fragments were detected in allografts during rejection, but not in normal lungs. The purpose of the current study was to isolate and characterize col(V)-specific allograft-infiltrating T cells and to determine their contribution to the rejection response in vivo. Two col(V)-specific T cell lines, LT1 and LT3, were isolated from F344 (RT1(lv1)) rat lung allografts during rejection that occurred after transplantation into WKY (RT1(l)) recipients. Both cell lines, but not normal lung lymphocytes, proliferated in response to col(V). Neither LT1 nor LT3 proliferated in response to alloantigens. LT1 and LT3 were CD4(+)CD25(-) and produced IFN-gamma in response to col(V). Compared with normal CD4(+) T cells, both cell lines expressed a limited V-beta TCR repertoire. Each cell strongly expressed V-beta 9 and 16, but differed in expression of other V-betas. Adoptive transfer of each cell line did not induce pathology in lungs of normal WKY rats. In contrast, adoptive transfer of LT1, but not LT3, caused marked peribronchiolar and perivascular inflammation in isograft (WKY) lungs and abrogated col(V)-induced oral tolerance to allograft (F344) lungs. Collectively, these data show that lung allograft rejection involves both allo- and autoimmune responses, and graft destruction that occurs during the rejection response may expose allograft-infiltrating T cells to potentially antigenic epitopes in col(V).  (+info)

Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. (5/105)

Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site.  (+info)

Release of biologically active TGF-beta1 by alveolar epithelial cells results in pulmonary fibrosis. (6/105)

Idiopathic pulmonary fibrosis (IPF) is a progressive fatal fibrotic lung disease. Transforming growth factor (TGF)-beta1 is present in a biologically active conformation in the epithelial cells lining lesions with advanced IPF. To determine the role of aberrant expression of biologically active TGF-beta1 by alveolar epithelial cells (AECs), the AECs of explanted normal rat lungs were transfected with the TGF-beta1 gene using the retrovirus pMX-L-s223,225-TGF-beta1. In situ hybridization using a digoxigenin-labeled cDNA of the puromycin resistance gene contained in the pMX demonstrated that pMX-L-s233,225-TGF-beta1 was selectively transfected into AECs of the explants. Conditioned media overlying explants obtained 7 days after being treated with pMX-L-s223,225-TGF-beta1 contained 14.5 +/- 3.15 pg/ml of active TGF-beta1. With the use of Masson's trichrome staining of explant sections obtained 14 days after transfection, there were lesions similar to those in IPF, characterized by type II AEC hyperplasia, interstitial thickening, extensive increase in interstitial and subepithelial collagen, an increase in the number of fibroblasts, and areas resembling fibroblast buds. Collagens I, III, IV, and V and fibronectin were increased in explants treated with pMX-L-s223,225-TGF-beta1. The findings in the current study suggest that IPF may be a disorder of epithelial cells and not inflammatory cells.  (+info)

Differential expression of Smad7 transcripts identifies the CD4+CD45RChigh regulatory T cells that mediate type V collagen-induced tolerance to lung allografts. (7/105)

Regulatory T cells (Tregs) induced by oral tolerance may suppress immunity by production of TGF-beta that could also enhance Treg activity. However, all cells that are phenotypically Tregs in rats (CD4(+)CD45RC(high)-RC(high)) may not have regulatory function. Because Smad7 expression in T cells is associated with inflammation and autoimmunity, then lack of Smad7 may identify those cells that function as Tregs. We reported that feeding type V collagen (col(V)) to WKY rats (RT1(l)) induces oral tolerance to lung allografts (F344-RT1(lvl)) by T cells that produce TGF-beta. The purpose of the current study was to identify the Tregs that mediate col(V)-induced tolerance, and determine Smad7 expression in these cells. RC(high) cells from tolerant rats were unresponsive to allogeneic stimulation and abrogated rejection after adoptive transfer. In contrast, CD4(+)CD45RC(low) (RC(low)) cells from tolerant rats and RC(high) or RC(low) cells from normal rats or untreated allograft recipients proliferated vigorously in response to donor Ags, and did not suppress rejection after adoptive transfer. TGF-beta enhanced proliferation in response to col(V) presented to tolerant RC(high), but not other cells. In contrast to other cells, only RC(high) cells from tolerant rats did not express Smad7. Collectively, these data show that the Tregs that mediate col(V)-induced tolerance to lung allografts do not express SMAD7 and, therefore, are permissive to TGF-beta-mediated signaling.  (+info)

Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen alpha5(IV) in experimental diabetic nephropathy and in glucose-stimulated podocytes. (8/105)

The 12-lipoxygenase (12-LO) pathway of arachidonic acid metabolism is implicated in extracellular matrix (ECM) synthesis, but its role in podocytes has not been studied. This study tested whether 12-LO induction by diabetes or by high glucose (HG) in cultured podocytes alters glomerular basement membrane by activating signal transduction pathways culminating in ECM synthesis. Sprague-Dawley rats received an injection of diluent (control [C]) or streptozotocin 65 mg/kg (DM) and were killed at 1 or 4 mo. Glomerular 12-LO mRNA and protein levels were higher in DM than in C glomeruli at 1 and 4 mo, and 12-LO localized predominantly in podocytes. Glomerular p38 mRNA and protein were higher in DM at months 1 and 4, but phospho-p38 mitogen-activated protein (MAPK) was increased only at month 1. Glomerular collagen alpha5(IV)/glutaraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA ratio was increased in DM at month 1 but not at month 4, whereas collagen alpha5(IV) protein was higher at both 1 and 4 mo. Mouse podocytes were cultured in media with 25 mM glucose (HG) with or without the 12-LO inhibitor cinnamyl-3,4-dihydroxy-cyanocinnamate (CDC) or with 5.5 mM glucose + 19.5 mM mannitol (low glucose [LG+M]) for 10 d at 37 degrees C. 12-LO mRNA and protein levels were higher in HG than in LG+M as was the p38 MAPK/GAPDH mRNA ratio. Phospho-p38 MAPK protein but not total p38 MAPK was higher in HG compared with LG+M. Collagen alpha5(IV)/GAPDH mRNA ratio and protein were higher in HG than in LG+M. 12-LO inhibition by CDC decreased HG-induced phospho-p38 MAPK and the phospho-p38/total p38 MAPK ratio, collagen alpha5(IV)/GAPDH mRNA ratio, and collagen alpha5(IV) protein expression. In summary, diabetes in vivo and exposure of podocytes to HG in vitro stimulated 12-LO, p38 MAPK, and collagen alpha5(IV) mRNA and (activated) protein. 12-LO inhibition by CDC diminished the expression of podocyte phospho-p38 MAPK and collagen alpha5(IV) mRNA and protein. These findings implicate 12-LO and the p38 MAPK signaling pathway in the mediation of ECM synthesis by podocytes in diabetes.  (+info)

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Type V collagen may play a role in graft rejection following lung transplants (See Review: Sumpter TL, Wilkes DS. Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the pathogenesis of lung transplant rejection. Am J Physiol Lung Cell Mol Physiol 2004; 286: L1129-39). It has been shown that oral tolerance induction by oral administration of type V collagen prevents lung allograft rejection in animal models, and is expected to be used for humans. Importantly, it has been reported that patients who were previously sensitized by type V collagen and positive for type V collagen-DTH reactions tend to develop idiopathic pulmonary fibrosis (58.8%, 10/17) compared to patients who were negative for the DTH reaction (15.8%, 6/38) (Bobadilla JL, Love RB, Jankowska-Gan E, Xu Q, et al. Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation. Am J Respir Crit Care Med 2008; 177: 660-8).. Type V and Type XI Collagen ...
Manipulations in cell culture and mouse models have demonstrated that reduction of collagen V results in altered fibril structure and matrix assembly. A tissue-dependent role for collagen V in determining mechanical function was recently established, but its role in determining regional properties has not been addressed. The objective of this study was to define the role(s) of collagen V expression in establishing the site-specific properties of the supraspinatus tendon. The insertion and midsubstance of tendons from wild type, heterozygous and tendon/ligament-specific null mice were assessed for crimp morphology, fibril morphology, cell morphology, as well as total collagen and pyridinoline cross-link (PYD) content. Fibril morphology was altered at the midsubstance of both groups with larger, but fewer, fibrils and no change in cell morphology or collagen compared to the wild type controls. In contrast, a significant disruption of fibril assembly was observed at the insertion site of the null ...
Complete information for COL5A3 gene (Protein Coding), Collagen Type V Alpha 3 Chain, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Collagen V兔多克隆抗体(ab7046)可与小鼠, 牛, 人样本反应并经WB, IP, IHC, ICC/IF, sELISA实验严格验证,被5篇文献引用并得到3个独立的用户反馈。
COL11A2 antibody [GT6410] (collagen, type XI, alpha 2) for WB. Anti-COL11A2 mAb (GTX629739) is tested in Human samples. 100% Ab-Assurance.
COL4A3 antibody (collagen, type IV, alpha 3 (Goodpasture antigen)) for ELISA, IHC-P, WB. Anti-COL4A3 pAb (GTX37323) is tested in Human, Mouse, Rat samples. 100% Ab-Assurance.
Anti-COL3A1 polyclonal antibody (STJ92388) was developed using a synthesized peptide derived from the N-terminal region of human COL3A1 at AA range: 50-130. This antibody is applicable for use in immunohistochemistry, immunofluorescence, ELISA and immunoc
Ziege Polyklonal COL4a6 Antikörper both Isoforms für ELISA. Publiziert in 2 Pubmed Referenzen. Jetzt diesen anti-COL4a6 Antikörper bestellen. | Produkt ABIN4264320
The featured research unveils that monitoring of transcription factor Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can be an early predictor of chronic rejection after lung transplant.
Organ transplant patients routinely receive drugs that stop their immune systems from attacking newly implanted hearts, livers, kidneys or lungs, which the body sees as foreign.
Yamagata, S; Miwa, M; Tanaka, K; and Yamagata, T, "Fbj virus-induced osteosarcoma has type v collagen consisting of a, b and c-like chains in addition to type i collagen." (1982). Subject Strain Bibliography 1982. 2868 ...
relation id=30000, ,member type=relation role=is_in ref=... /, ,tag k=type v=address /, ,tag k=address:type v=a3 /, ,tag k=name v=München /, ,tag k=name:en v=Munich /, ,/relation, ,relation id=30010, ,member type=relation role=is_in ref=30000 /, ,tag k=type v=address /, ,tag k=address:type v=a4 /, ,tag k=name v=Maxvorstadt /, ,/relation, ,relation id=30011, ,member type=relation role=is_in ref=30000 /, ,tag k=type v=address /, ,tag k=address:type v=a4 /, ,tag k=name v=Schwabing-Freimann /, ,/relation, ,relation id=30020, ,member type=relation role=is_in ref=30010 /, ,tag k=type v=address /, ,tag k=address:type v=pc /, ,tag k=name v=80802 /, ,/relation, ,relation id=30021, ,member type=relation role=is_in ref=30011 /, ,tag k=type v=address /, ,tag k=address:type v=pc /, ,tag k=name v=80802 /, ,/relation, ,relation id=30022, ,member type=relation role=is_in ref=30010 /, ,tag k=type ...
6v^2 - 4 + 9v +v^3)/ (v - 4)i am just a little lost can someone explain this to me. thanks. Arrange the polonomial in descending order... v^3-6v^2 +9v -4 Then divide. v-4 !v^3-6v^2 +9v -4 The first term is v^2, so v^2*(v-4) is v^3-4v^2 ...
上年小V在旅遊雜誌上見到介紹台灣秘景,其中一站是位於彰化,有全台灣唯一的海牛採蚵活動,雜誌圖片再配上迷人的芳苑日落,令彰化芳苑成為小V旅行的口袋名單之一。很幸運上年成功搶到HK$22機票到台中,使我這次可以有藉口到台中附近的彰化走走。. 談到彰化旅行,最煩就是交通的問題… 除了彰化市,基本上我覺得整個彰化的交通系統不太完善。說是要到芳苑去,一個位於彰化西邊沿海又很偏僻的地方,台灣好行的班次由平日每天2、3班至假日每天6班也有。再者,海牛採蚵活動在早上8點開始嚕,根本沒有那麼早的公車。不用煩… 不用煩… 最後,小V決定包車遊彰化一天。. 我跟大灰熊就是由彰化玩到台中去,玩一天,晚上宿台中。主要的行程都在彰化,但當天司機大哥說車子會順路經過台中彩虹眷村,所以又多了一個景點。呵!. ...
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Hello! This is the final part of this information. According to the ezine sent out by Ms. Ruth Ryden, she received this information in the late 1990s. She re-released
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അണുസംഖ്യ 23 ആയ മൂലകമാണ് വനേഡിയം. V ആണ് ആവർത്തനപ്പട്ടികയിലെ ഇതിന്റെ പ്രതീകം. ജീവജാലങ്ങളിൽ കണ്ടുവരുന്ന 26 മൂലകങ്ങളിൽ ഒന്നാണ് വനേഡിയം. പ്രകൃതിയിൽ 65ഓളം അയിരുകളിൽ കാണപ്പെടുന്ന ഇത് ലോഹസങ്കരങ്ങളുണ്ടാക്കനായി ഉപയോഗിക്കപ്പെടുന്നു. വടക്കേ അമേരിക്കയിലെ മെക്സിക്കോയിൽ നിന്നും കണ്ടെത്തിയ ഒരു ധാതുവിന്റെ രാസവിശ്ലേഷണത്തിൽ നിന്നും നീൽസ് സെഫ്സ്ട്രോം എന്ന ശാസ്ത്രജ്ഞനാണ് വനേഡിയം ...
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Respiratory viral infection (RVI) following human lung transplantation (LTx) increases the risk for chronic rejection. We demonstrated that lung transplant recipients (LTxR) with acute and chronic rejection induce exosomes containing HLA and self-antigens (SAg), Kα1Tubulin (Kα1T) and Collagen V (Col-V). We determined whether RVI can induce exosomes containing SAg leading to immune response resulting in rejection and their immunogenicity in mice. Sera from RVI (n=35) and stable LTxR (n=32) were used for exosomes isolation and Abs to SAg. Exosomes were isolated by ultracentrifugation, validated by sucrose cushion and tested for CD-9. SAg, viral antigens for respiratory syncytial virus (RSV), corona virus (CV) and rhino virus (RV) were detected by immunoblot. Exosomes from RVI and stable LTxR were injected subcutaneously (10[micro]g/100[micro]l) into C57BL/6 mice. Sera were analyzed for Abs to SAg by ELISA. Since studies have shown that a primary insult to lung is needed for Abs to SAg to induce ...
AIM: To obtain some insight into the extracellular matrix in the placenta, changes in the composition of collagens during placental development were investigated. METHODS: Collagen was extracted from placentas (group 1, 25-30 weeks, n = 21; group 2, 31-36 weeks, n = 32; and group 3, 37-41 weeks of gestation, n = 40) and the relative concentrations of various collagens were evaluated by SDS-PAGE. RESULTS: The ratio of the intensity of the alpha 1 (III) band to that of alpha 1 (I) chain collagen in group 3 placentas were lower than those in group 1 placentas. In contrast, the ratio of the intensity of the alpha 1 (V) band to that of alpha 1 (I) chain collagen in group 3 placentas were higher than those in group 1 and group 2 placentas. CONCLUSIONS: These results suggest that type V collagen might play an important role in the function of the placenta and that an increased relative concentration of type V collagen might be closely associated with the development and ageing of the placenta.. ...
Tendons are able to withstand the broad range of stresses and strains via their finely tuned composition and structure. In addition, tendons undergo a coordinated set of dynamic responses, specifically collagen uncrimping, re-alignment, sliding and deformation, within the matrix. To date, a complete understanding of the hierarchical structure-function relationships in tendon is lacking. Therefore, the overall goal of this thesis was to measure tendon structure and function in a mouse supraspinatus model of altered structure, and to analyze links between mechanical properties, dynamic processes and composition/structure using a series of statistical analyses. In the studies presented here, we used novel and established methods to measure the multi-scale composition, structure and mechanical function of mouse supraspinatus tendons from wild type, collagen V heterozygous and collagen V null mice. Overall, we found that the experimental groups were mechanically inferior to the wild type group, with larger
These triple-stranded, rope-like pro-collagen molecules must be processed by enzymes outside the cell. Once these molecules are processed, they arrange themselves into long, thin fibrils that cross-link to one another in the spaces around cells. The cross-links result in the formation of very strong, mature type V collagen fibers ...
مخططات وطلاءات، ونطاقات الألوان، والتركيبات، والتدرجات، والفضاء اللوني، والتحويلات لألوان ‎#8e72c7 الست عشرية.
Mi 12-14 in V2-213; Fr 12-14 in U2-113; Do 10-12, einmalig in V3-201; Do 12-14, einmalig in T2-228; Do 10-12, einmalig in V3-201; Do 12-14, einmalig in T2-228; Do 12-14, einmalig in T2-228; Do 12-14, einmalig in T2-228; Do 10-12, einmalig in V2-105/115; Do 12-14, einmalig in T2-228; Do 12-14, einmalig in T2-228 ...
N rlund Hestehospital: Them : V t rinaire: Prestataires m dicaux : Guide annuaire Prestataires et Lieux dexposition, congr s...
44339119 -OEChem-10101305022D 37 39 0 0 0 0 0 0 0999 V2000 8.0785 2.9476 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.9962 0.3922 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.0785 -1.1215 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.9271 -2.6315 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.8105 -1.1416 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 0.4131 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 0.4131 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 1.4130 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -0.0869 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3301 -0.0869 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 1.4130 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3301 1.9130 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0901 -0.1216 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7320 0.4131 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -1.0870 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0901 1.9477 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -1.0870 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -0.0869 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7320 -1.5870 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9962 1.4339 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 ...
We included three studies that enrolled a total of 413 adult patients that compared tacrolimus with microemulsion or oral solution cyclosporin. All studies were found to be at high risk of bias. Tacrolimus seemed to be significantly superior to cyclosporin regarding the incidence of bronchiolitis obliterans syndrome (RR 0.46, 95% CI 0.29 to 0.74), lymphocytic bronchitis score (MD -0.60, 95% CI -1.04 to -0.16), treatment withdrawal (RR 0.27, 95% CI 0.16 to 0.46), and arterial hypertension (RR 0.67, 95% CI 0.50 to 0.89). However, the finding for arterial hypertension was not confirmed when analysed using a random-effects model (RR 0.54, 95% CI 0.17 to 1.73). Furthermore, trial sequential analysis found that none of the meta-analyses reached the required information sizes and cumulative Z-curves did not cross trial sequential monitoring boundaries. Diabetes mellitus occurred more frequently among people in the tacrolimus group compared with the cyclosporin group when the fixed-effect model was ...
Researchers at the San Francisco VA Medical Center (SFVAMC) and the Un...The researchers hope their results will lead to an earlier more sensi...The study is being published in the September 2005 issue of the Journa...In obliterative bronchitis scar tissue forms in breathing passages of... For lung transplant patients the biggest barrier to long-term surviv...,Researchers,identify,genes,associated,with,lung,transplant,rejection,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Collagen alpha-1(V) chain is a protein that in humans is encoded by the COL5A1 gene. This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Type-V collagen GRCh38: Ensembl release 89: ENSG00000130635 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000026837 - Ensembl, May 2017 "Human PubMed Reference:". "Mouse PubMed Reference:". Greenspan DS, Byers MG, Eddy RL, Cheng W, Jani-Sait S, Shows TB (May 1992). "Human collagen gene ...
Implementation of an evidence-based guideline for managing respiratory and hemodynamic status is feasible and safe and was associated with reduction in severity of primary graft dysfunction. Further studies are required to determine whether such a guideline would lead to a consistent reduction in severity of primary graft dysfunction at other institutions. Creation of a protocol for postoperative care provides a template for further studies of novel therapies or management strategies for primary graft dysfunction ...
What is ehlers-danlos syndrome eds? Learn about ehlers-danlos syndrome eds symptoms, ehlers-danlos syndrome eds causes, diagnosis, and more.
Principal Investigator:SEKINE Yasuo, Project Period (FY):2003 - 2005, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Thoracic surgery
The immunohistopathology of the intrinsic basement membrane-associated antigens were examined in diabetic nephropathy. In early and moderate stages of disease there was polyantigenic expansion of all the intrinsic components of mesangium, glomerular basement membrane (GBM), and tubular basement membrane (TBM) assessed by polyclonal antisera to collagen types IV and V, laminin, and by monoclonal antibodies to type IV collagen and fibronectin and to four other intrinsic components of normal renal extracellular matrices (MBM10, 11, 12, and 15). In the mesangium the first intrinsic antigens to increase were fibronectin and type V collagen. In late stages of disease, there was a diminution in the mesangium of all of these antigens with the exception of type V collagen, which persisted. Additionally, antigens appeared in the mesangium, recognized by MBM11 and MBM15, which are normally present in fetal but not adult mesangial regions. Similarly, in the GBM in late stages of disease, there was a ...
Acute lung injury within 72 hours of lung transplantation, termed Primary Graft Dysfunction (PGD), is a major cause of early post-transplant morbidity and morta...
Ehlers-Danlos syndrome: Ehlers-Danlos syndrome,, rare, heritable disorder characterized by great elasticity of the skin, skin fragility with a tendency to hemorrhage, poor scar formation, and
Im 16.Ive always been active in sports, etc,but was diagnosed with scoliosis at 12. Since scoliosis doesnt cause pain apparently, it took several doctors and a different hospital to discover the real cause- Ehlers-Danlos Syndrome, hypermobility type. It causes weakened joints, etc, and reasonably explains my pain.However, two or so weeks ago, the pain was so severe that i had to be hospitalized and given several narcotics to eliminate it. I didnt recover for two weeks.Does anyone else have this disease or know anything that can eliminate my near-constant back and knee pain? Im willing to try anything at this point. I feel like Im wayyyy too young to be in pain all the time.thanks so much!I wish I could tell you that you are too young for all the pain you have to endure! I was diagnosed with Ehlers-Danlos Syndrome when I was around 30. Before that most doctors said it was in my head.The best thing Ive found to relieve the pain is a jaccuzi. However they can be hard to come by, so there ...
Ehlers-Danlos syndrome (EDS) is a group of clinically and genetically heterogeneous heritable connective tissue disorders (Yeowell and Pinnell 1993) affecting the skin, ligaments, joints, blood...
Ehlers-Danlos syndrome is a group of inherited disorders that affect your connective tissues - primarily your skin, joints and blood vessel walls. Connective tissue is a complex mixture of proteins and other substances that provides strength and elasticity to the underlying structures in your body.
Ehlers-Danlos syndrome is a group of inherited disorders that affect the connective tissues of the skin, joints and walls of the blood vessels. It is characterized by flexible joints and fragile skin.
Ehlers-Danlos syndrome (EDS) is a group of inherited conditions. These conditions affect the connective tissues. This type of tissue is found all over the body. There are at least 6 different varieties of EDS. They are classified by the type of tissue most affected and how it is inherited.
Ehlers-Danlos syndrome, cardiac valvular form information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Biologixs calling all zebras! At Biologix, we assist individuals with Ehlers-Danlos syndromes and hypermobile spectrum disorders (HSD) in find relief and comfort they seek. Contact Biologix to learn more about our 10-point treatment plan today!
This article focuses on a presentation by Dr. Rodney Graham about Ehlers-Danlos Syndrome, better known by the general public as joint-hypermobility. Dr. Graham is a rheumatologist from the U.K. who has devoted much of his career to this specific illness.
A woman with Ehlers-Danlos syndrome explains how she realized that its OK to not be independent in the way she thought she had to be.
Online Doctor Chat - Ehlers-danlos syndrome, Ask a Doctor about when and why Magnetic resonance imaging is advised, Online doctor patient chat conversation by Dr. Yogesh D
Learn more about Ehlers-Danlos Syndrome at Palms West Hospital DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
My teen daughter was at a friends walking and looking at her phone and ran into the wall fracturing her radius. Her wrist was in an odd position that she could not move out of when I picked her up. I ...
hey everyone, I am sure many of you can relate to what Im feeling but sometimes i just feel so alone. I feel like searching for answers to my pain is useless, and that at some point I should just giv...
The Driscoll Theory® Newly Revised · The Cause of POTS in Ehlers-Danlos Syndrome and How to Reverse the Process by Diana Driscoll (Author), Ananya De…
2416850 管の穴から天を覗く v5k 2418930 断じて行えば鬼神も之を避く v5k 2418010 焼け棒杭に火が付く v5k 2451240 想像が付く v5k 2068870 閑古鳥が鳴く v5k 2418940 男鰥に蛆が湧く v5k 2417090 群羊を駆って猛虎を攻む v5m 2419790 無理が通れば道理が引っ込む v5m 2417000 金が子を生む v5m 2417970 小の虫を殺して大の虫を生かす v5s 1213500 甘言は偶人を喜ばす v5s 2141210 網呑舟の魚を漏らす v5s 2108430 入るを量りて出ずるを為す v5s 2417990 小人閑居して不善を為す v5s 1470130 能ある鷹は爪を隠す v5s 2397070 噂をすれば影が射す v5s 2419300 入るを計りて出ずるを制す v5s 2418670 先んずれば人を制す v5s 2419160 桃李物言わざれども下自ら蹊を成す v5s 2417910 女の一念岩をも通す v5s 2417640 思う念力岩をも徹す v5s 2095220 群盲象を評す v5s 2417080 君子豹変す v5s 2420120 歴史は繰り返す v5s 2417790 車軸を流す ...
2416850 管の穴から天を覗く v5k 2418930 断じて行えば鬼神も之を避く v5k 2418010 焼け棒杭に火が付く v5k 2451240 想像が付く v5k 2068870 閑古鳥が鳴く v5k 2418940 男鰥に蛆が湧く v5k 2417090 群羊を駆って猛虎を攻む v5m 2419790 無理が通れば道理が引っ込む v5m 2417000 金が子を生む v5m 2417970 小の虫を殺して大の虫を生かす v5s 1213500 甘言は偶人を喜ばす v5s 2141210 網呑舟の魚を漏らす v5s 2108430 入るを量りて出ずるを為す v5s 2417990 小人閑居して不善を為す v5s 1470130 能ある鷹は爪を隠す v5s 2397070 噂をすれば影が射す v5s 2419300 入るを計りて出ずるを制す v5s 2418670 先んずれば人を制す v5s 2419160 桃李物言わざれども下自ら蹊を成す v5s 2417910 女の一念岩をも通す v5s 2417640 思う念力岩をも徹す v5s 2095220 群盲象を評す v5s 2417080 君子豹変す v5s 2420120 歴史は繰り返す v5s 2417790 車軸を流す ...
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В.М. Балебанов, А.А. Боярчук, Н.С. Ерохин, В.Е. Захаров, Л.М. Зеленый, В.И. Карась, Б. Коппи, Э.П. Кругляков, Р.А. Коврижкин, Е.А. Кузнецов, А.Г. Литвак, Я.Г. Ломинадзе, Г.А. Месяц, А.Б. Михайловский, Е.В. Мишин, С.С. Моисеев, В.Н. Ораевский, О.А. Похотелов, Р.З. Сагдеев, К.Н. Степанов, Р.А. Сюняев, Я.Б. Файнберг, А.М. Фридман, Альберту Абубакировичу Галееву - 60 лет, Физика плазмы, 27 (3), 287-288 (2001) [V.M. Balebanov, A.A. Boyarchuk, N.S. Erokhin, V.E. Zakharov, L.M. Zelenyi, V.I. Karas, B. Coppi, É.P. Kruglyakov, R.A. Kovrazhkin, E.A. Kuznetsov, A.G. Litvak, J.G. Lominadze, G.A. Mesyats, A.B. Mikhailovskii, E.V. Mishin, S.S. Moiseev, V.N. Oraevskii, O.A. Pokhotelov, R.Z. Sagdeev, K.N. Stepanov, R.A. Syunyaev, Ya.B. Fainberg, A.M. ...
I. N. Leontyev, D. V. Leontyeva, A. B. Kuriganova, Y. V. Popov, O. A. Maslova, N. V. Glebova, A. A. Nechitailov, N. K. Zelenina, A. A. Tomasov, L. Hennet, and N. V. Smirnova ...
Akhmanov S.A., Bayanov I.M., Gaponov S.V., Gordiyenko V.M., Dzhidzhoyev M.S., Ivanov V.V., Krayushkin S.V., Magnitsky S.A., Platonenko V.T., Platonov Y.Y., Ponomaryov Y.V., Savelyev A.B., Salashchenko N.N., Slobodchikov E.V., Tarasevich A.P ...
Fisunov G.Y., Alexeev D.G., Bazaleev N.A., Ladygina V.G., Galyamina M.A., Kondratov I.G., Zhukova N.A., Serebryakova M.V., Demina I.A., Govorun V.M ...
Chronic rejection significantly limits long-term success of solid organ transplantation. De novo donor-specific antibodies (DSAs) to mismatched donor human leukocyte antigen after human lung transplantation predispose lung grafts to chronic rejection. We sought to delineate mediators and mechanisms of DSA pathogenesis and to define early inflammatory events that trigger chronic rejection in lung transplant recipients and obliterative airway disease, a correlate of human chronic rejection, in mouse. Induction of transcription factor zinc finger and BTB domain containing protein 7a (Zbtb7a) was an early response critical in the DSA-induced chronic rejection. A cohort of human lung transplant recipients who developed DSA and chronic rejection demonstrated greater Zbtb7a expression long before clinical diagnosis of chronic rejection compared to nonrejecting lung transplant recipients with stable pulmonary function. Expression of DSA-induced Zbtb7a was restricted to alveolar macrophages (AMs), and ...
This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II ...
TY - JOUR. T1 - Cell-Free Hemoglobin-mediated Increases in Vascular Permeability. A Novel Mechanism of Primary Graft Dysfunction and a New Therapeutic Target. AU - Shaver, Ciara M.. AU - Wickersham, Nancy. AU - McNeil, J. Brennan. AU - Nagata, Hiromasa. AU - Sills, Gillian. AU - Kuck, Jamie L.. AU - Janz, David R.. AU - Bastarache, Julie A.. AU - Ware, Lorraine B.. PY - 2017/9/1. Y1 - 2017/9/1. N2 - RATIONALE: Cell-free hemoglobin (CFH) is a potent oxidant associated with poor clinical outcomes in a variety of clinical settings. Recent studies suggest that acetaminophen (APAP), a specific hemoprotein reductant, can abrogate CFH-mediated oxidative injury and organ dysfunction. Preoperative plasma CFH levels are independently associated with primary graft dysfunction (PGD) after lung transplant ( 1 ).OBJECTIVES: Our objectives were to determine whether CFH would increase lung vascular permeability in the isolated perfused human lung and whether APAP would limit these effects.METHODS: Human lungs ...
Summary. "Ehlers-Danlos Syndrome is a rare disorder, comprising a group of related inherited disorders of connective tissue, resulting from underlying abnormalities in the synthesis and metabolism of collagen. This proposal is specifically concerned with Ehlers-Danlos syndrome classic type (formerly Types I-III), which is characterized by joint hypermobility and susceptibility to injury/arthritis, skin and vascular problems (including easy bruising, bleeding, varicose veins and poor tissue healing), cardiac mitral valve prolapse, musculo-skeletal problems (myopathy, myalgia, spinal scoliosis, osteoporosis), and susceptibility to periodontitis. No treatment is currently available for this disorder. The novel aspect of this proposal is based on: (i) increasing scientific evidence that nutrition may be a major factor in the pathogenesis of many disorders once thought to result from defective genes alone; (ii) the recognition that many of the symptoms associated with Ehlers-Danlos syndrome are also ...
PubMed journal article Primary graft dysfunction and long-term pulmonary function after lung transplantatio were found in PRIME PubMed. Download Prime PubMed App to iPhone or iPad.
Ehlers-Danlos syndrome (EDS) is a heterogeneous group of inherited connective tissue disorders that can vary from loose joints to life-threatening complications, depending on type. The vascular form of EDS, which is estimated to affect 1 in 250,000 people
Could you imagine living in constant, chronic pain? Try to picture waking up experiencing agonizing pain; envision going about your day hurting, and then going back to sleep at night, the way you felt when you woke up, or possibly worse. Every day, every hour, every minute, every second. Now attempt to imagine not being able to get rid of that pain, no matter what you do. Its always there.. This is the reality that Lancaster resident Karley Hill lives in. She has a type of a disease called Ehlers-Danlos Syndrome (EDS), an inherited disorder that affects about 1 in 5,000 people and is caused by faulty collagens. And when we heard about Karley through someone at the church, the church school jumped at the opportunity to make Karley the focus of our Advent project this year. We started by selling beautiful poinsettias at the church; buyers had the option of buying them for themselves and/or donating some to the church (I would like to mention that the back of our mini-van looked so pretty on the ...
Learn more about Ehlers-Danlos Syndrome at Medical City Plano DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Chronic lung allograft dysfunction (CLAD) is, in one sense, a term without a true consensus definition, although its common usage in the field of lung transplantation implies a base understanding throughout the community that it describes a lung allograft that does not work (well) [1]. There appears to be general agreement that CLAD most commonly occurs in a time-dependent fashion after transplant and is a harbinger of a foreshortened survival [2]. However, different phenotypes have been described based on a combination of physiological and radiological features [3]. A restrictive ventilatory defect, with or without interstitial pulmonary infiltrates and/or pleural thickening, has the worst prognosis and is also associated with inferior results from attempts at salvage by retransplantation [4]. One curious feature of the natural history of CLAD is the chameleon-like property of morphing from one predominant phenotype to another [5]. Perhaps this bespeaks our simplistic understanding of the root ...
DC develops as a result of increased and uncontrolled fibroblast proliferation, as well as due to the deposition of type II and type V collagen and glycosaminoglycans in the palmar aponeurosis.18 The cause of this fibrosis has not yet been elucidated. The treatment is traditionally surgery, meticulously exposing the fibrotic fascia and excising the constricting cords, thereby releasing the flexure-contracture. These procedures are demanding of skills and resources with quite a long convalescence period, mostly due to the wide dissection field, surgically-related adverse events and high recurrence rates (12% to 39%, with a mean follow-up time of 1.5 to 7.3 years).19 In order to reduce surgical trauma, enzymatic fasciotomy for DC has previously been tried. It was first introduced by Hueston in 1971, using a mixture of trypsin, hyaluronidase, and lidocaine injected into the cord during surgery.20 McCarthy21 reported long-term results with the same mixture; he noticed recurrence in seven of nine of ...
The Role of Macrophages in the Response to Aspirated Gastric Fluid in Lung Allograftss profile, publications, research topics, and co-authors
The RGD motif in fibronectin is essential for development but dispensable for fibril assembly.s profile, publications, research topics, and co-authors
If you think you might have one of the Ehlers-Danlos syndromes (EDS) or hypermobility spectrum disorders (HSD), and particularly if someone in your immediate family has been diagnosed, ask your doctor if a diagnosis fits your symptoms. If they choose to, any doctor who can diagnosis a disease is able to diagnose EDS/HSD; but most likely youll be given a referral to a geneticist, because EDS are genetic disorders and geneticists are most adept at distinguishing between those diseases, as well as in doing any testing necessary to differentiate EDS/HSD from the more than 200 other heritable connective tissue disorders.. A diagnosis is important because, although EDS/HSD are not curable, they are treatable. Knowing the type of EDS/HSD gives you and your medical team some idea of where problems might come from and why theyre happening. When eventually there is a cure, youll know to use it. And as more of us are diagnosed, EDS/HSD gain the attention all of us need, increasing the likelihood of ...
Thansk to Janet for this 2013 article abstract which made me think - skin is so important in temperature regulation Perhaps some skin defect also...
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Dr. Friedlander responded: Usually none. The diagnosis is usually made on physical examination. Since its not something that can be treated with a pill, theres seldom any need to find the exact gene responsible (and there are many different ones that can do it). For the very severe vascular form, a geneticist may confirm this, before or after birth. I know several docs with e-d. Good luck.
Kharat SS, Tripathi V, Damodaran AP, Priyadarshini R, Chandra S, Tikoo S, Nandhakumar R, Srivastava V, Priya S, Hussain M, Kaur S, Fishman JB, Sengupta S ...
Lung transplantation has become a therapeutic option for a number of end-stage pulmonary disorders. Lung transplant recipients experience more complications due to acute and chronic allograft rejection as compared to recipients of other solid organs. We postulated that the generation of TNF-alpha plays a significant role in the pathogenesis of acute lung allograft rejection. To test our hypothesis, we used a RT1-incompatible rat lung allograft model and demonstrated the time course, cellular source(s), and major compartment(s) of TNF production during the course of lung allograft rejection. This model allowed for immunogenetic standardization and reproducibility of lung allograft rejection across disparate major histocompatibility barriers. TNF production was characterized at the whole animal, organ, cellular, and molecular levels, and was found to be compartmentalized and expressed in a bimodal fashion from the lung allograft during lung allograft reimplantation and maximal rejection. Lung ...
TY - JOUR. T1 - A panel of lung injury biomarkers enhances the definition of primary graft dysfunction (PGD) after lung transplantation. AU - Shah, Rupal J.. AU - Bellamy, Scarlett L.. AU - Localio, A. Russell. AU - Wickersham, Nancy. AU - Diamond, Joshua M.. AU - Weinacker, Ann. AU - Lama, Vibha N.. AU - Bhorade, Sangeeta. AU - Belperio, John A.. AU - Crespo, Maria. AU - Demissie, Ejigayehu. AU - Kawut, Steven M.. AU - Wille, Keith M.. AU - Lederer, David J.. AU - Lee, James C.. AU - Palmer, Scott M.. AU - Orens, Jonathan. AU - Reynolds, John. AU - Shah, Ashish. AU - Wilkes, David S.. AU - Ware, Lorraine B.. AU - Christie, Jason D.. PY - 2012/9. Y1 - 2012/9. N2 - Background: We aimed to identify combinations of biomarkers to enhance the definition of primary graft dysfunction (PGD) for translational research. Methods: Biomarkers reflecting lung epithelial injury (soluble receptor for advance glycation end products [sRAGE] and surfactant protein-D [SP-D]), coagulation cascade (plasminogen ...
Vascular Ehlers-Danlos Syndrome (VEDS), previously called Ehlers-Danlos syndrome type-IV, is a heterogeneous group of heritable connective tissue disorders characterized by thin, translucent skin, easy bruising, arterial, intestinal, and/or uterine fragility. There is large vessel involvement that leads to arterial rupture often preceded by aneurysm, arteriovenous fistulae, or dissection. Noninvasive imaging studies such as CT angiography and MR angiography are preferred as diagnostic studies for this condition. We are reporting a 4 years old girl who was presented with right sided unilateral convulsions and hypertension. CT angiogram showed stenosis with post-stenotic dilatation of coeliac and superior mesenteric arteries. There were extensive calcified plaques with atherosclerotic changes in the segment of right common iliac artery with aneurysmal dilatation of celiac, superior mesenteric and common iliac artery. Radiological findings were consistent with vascular Ehlers-Danlos syndrome. She was
When you have constant, non-stop whooshing in your head (no, not just tinnitus), youve been diagnosed with Classical Ehlers-Danlos syndrome (CEDS) 3x, but genetic testing came back negative, and the EDS world really doesnt know what you have - other than you have some kind of connective tissue disorder thats not Marfan Syndrome, VEDS, or other more common mutations …… They do know that you have 2 CBS Gene mutations and a few other genetic mutations, but they havent determined how any, if at all, play a role in a type of EDS, or a connective tissue disorder that "looks like" Classical/Vascular/Hypermobility-types of EDS. And theres no identified genetic marker(s) for Hypermobility type Doctors and genetic testing has also determined that you have 2 CBS Gene mutations and a few other genetic mutations, but they havent determined how any, if at all, play a role in a type of EDS, or a connective tissue disorder that "looks like" Classical/Vascular/Hypermobility-types of EDS. And theres no ...
Wendy is a perky, vivacious adolescent entering middle school with a lifelong vision of becoming an cheerleader. Wendy has been called bendy by family and friends because shes been limber and flexible throughout her life, earning her the nickname Bendy Wendy.. As soon as shes about to realize her ultimate aspiration of making the cheerleading squad as a flyer, Wendy worries that her dream will be shattered by constant physical issues plaguing her during rigorous practices and performances.. On the outside, Wendy looks perfectly normal, but clearly something more is going on. Join Wendy and her parents on their journey through a diagnosis and revelations of Ehlers-Danlos Syndrome / joint hypermobility, an almost invisible genetic syndrome.. "Bendy Wendy and the (Almost) Invisible Genetic Syndrome… A story of one tweens diagnosis of Ehlers-Danlos Syndrome / joint hypermobility" was written to fill a need for families, children, and tweens that find themselves in a position of ...
The Ehlers-Danlos Support Group UK is an international non-profit self-help organization dedicated to informing, encouraging, and assisting those with Ehlers-Danlos Syndrome (EDS) and their family members. Ehlers-Danlos Syndrome (EDS) is a group of rare inherited connective tissue disorders characterized by abnormalities of the skin, ligaments, and internal organs. Although symptoms and physical features may vary greatly depending upon the specific form of EDS present, many affected individuals may have thin, fragile, hyperextensible skin that may bruise easily; abnormally loose joints that are prone to repeated dislocations; widespread tissue fragility with bleeding and poor healing of wounds; and/or other abnormalities. Established in 1992, the Ehlers-Danlos Support Group UK is committed to raising awareness of EDS among the medical and professional communities; supporting research into the causes, treatment, and cure of EDS; and enabling members of the organization to exchange information, ...
Diagnosis of the cause of death in young people is a challenge to both the clinician and the pathologist. Ehlers-Danlos syndrome (EDS) type IV is an inherited connective tissue disorder. It is characterised by thin translucent skin, abnormal fragility of blood vessels, and a typical facial appearance. The cause of death is usually due to large arterial rupture. We describe an unusual case of a 23-year-old man clinically diagnosed with myocarditis, who suffered from recurrent pulmonary haemorrhage and died of massive myocardial haemorrhage and ischaemia without coronary artery disease. Diagnosis of EDS type IV was made by autopsy. To our knowledge, this is the first such report in the literature. Delay in diagnosing this syndrome is common even when clinical features are typical, and the condition often goes unrecognised until necropsy. The diagnosis of EDS should be considered in young people who seek medical attention because of arterial rupture. ...
extracellular matrix, collagen V binding, heparin binding, extracellular matrix organization, positive regulation of cell-substrate adhesion
Connective Tissue Disorders: If you have a CTD such as Lupus, Rheumatoid Arthritis, Sjogrens or MCTD you may qualify for long term disability (LTD) benefits
Information on Ehlers-Danlos syndrome, a condition that affects the connective tissues in the body. Learn the causes, symptoms, diagnosis and treatment options from St. Louis Childrens Hospital.
The Ehlers-Danlos syndromes (EDSs) were originally described by Ehlers in Denmark and Danlos in Paris in 1898 and 1908, respectively. They had both published individual case studies in which the common factor was laxity of ligaments leading to joint hypermobility and hyperextensibility of the skin. The choice of the name of this eponymous disease had been made by Dr Parkes Weber, an eminent London physician in the 1930s, who had a penchant for eponymous diseases, having had no less than seven attributed to himself, at least in part. Unfortunately, this was before the age of a computerised literature search, and Parkes Weber had inadvertently overlooked the very first description of EDS which had been made by Tchernabogov, a Russian dermatologist, whose description was published in 1891 and remains one of the best descriptions of EDS in the literature.
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Program Director/Principal Investigator (Last, First, Middle): Welgt, Stephen, Samuel PROJECT SUMIVIARY (See instructions): , This proposal outlines a five year...
This is a new section which is currently under construction and will possibly take some time to complete. However, please feel free to have a mooch-in to check if anything new has been added. Wishing you wellness Carole Sian Scrafton :-) Co-Founder - FibroFlutters
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McLean, VA (PRWEB) March 05, 2014 -- The Ehlers-Danlos National Foundation (EDNF) is pleased to announce that registration for the worlds largest gathering of
Microscopic studies of OI bone identified a subset of people who are clinically within the OI Type IV group but have distinctive patterns to their bone. Review of the clinical histories of these people uncovered other common features. As a result of this research, two types Type V and Type VI were added to the Sillence Classification. Regarding these types, it is important to note the following:. ...
Retrieved from "https://en.wikipedia.org/w/index.php?title=Collagen,_type_XX,_alpha_1&oldid=705418915" ...
Type III collagen. liver, bone marrow, and lymphatic organs USES[edit]. Connective tissue has a wide variety of functions that ... Type I collagen is present in many forms of connective tissue, and makes up about 25% of the total protein content of the ... Type I Collagen". Journal of Biological Chemistry. 277 (6): 4223-31. doi:10.1074/jbc.M110709200. PMID 11704682.. ... Types of fibers: Tissue. Purpose. Components. Location Collagenous fibers. Bind bones and other tissues to each other. Alpha ...
COL1A1: collagen, type I, alpha 1 (17q21.33). *LUC7L3: LUC7 like 3 pre-mRNA splicing factor (17q21.33) ... This type of ideogram is generally used in genome browsers (e.g. Ensembl, UCSC Genome Browser). ... This type of ideogram represents actual relative band length observed under a microscope at the different moments during the ...
The menisci contain 70% type I collagen.[6] The larger semilunar medial meniscus is attached more firmly than the loosely fixed ... In 1978, Shrive et al. reported that the collagen fibers of the menisci are oriented in a circumferential pattern.[6] When a ... This type of rehabilitation focuses on maintenance of full range of motion and functional progression without aggravating the ... Torg J, Quesdenfeld T (1971). "Effect of shoe type and cleat length on incidence and severity of knee injuries among high ...
... and type III collagen is largely replaced by type I. Collagen which was originally disorganized is cross-linked and aligned ... They begin to produce the much stronger type I collagen. Some of the fibroblasts mature into myofibroblasts which contain the ... Fibroblasts quickly produce abundant type III collagen, which fills the defect left by an open wound. Granulation tissue moves ... In order for an injury to be healed by regeneration, the cell type that was destroyed must be able to replicate. Cells also ...
Type II Collagen is an example of homo-trimeric protein. Porins usually arrange themselves in membranes as trimers. ...
COL7A1: Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) ... This type of ideogram is generally used in genome browsers (e.g. Ensembl, UCSC Genome Browser). ... FRA3A encoding protein Fragile site, aphidicolin type, common, fra(3)(p24.2). *FRMD4B encoding protein FERM domain containing ... ZBED2: encoding protein Zinc finger BED-type containing 2. *ZNF9: zinc finger protein 9 (a cellular retroviral nucleic acid ...
Type I collagen is present in many forms of connective tissue, and makes up about 25% of the total protein content of the ... Type I Collagen". Journal of Biological Chemistry. 277 (6): 4223-31. doi:10.1074/jbc.M110709200. PMID 11704682.. ... TypesEdit. Connective tissue can be broadly subdivided into connective tissue proper, and special connective tissue.[5][6] ... groups of adipose cells are kept together by collagen fibers and collagen sheets in order to keep fat tissue under compression ...
Horton, WA, Campbell, D, Machado, MA & Chou, J; Campbell; Machado; Chou (1989). "Type II collagen screening in the human ... Gajko-Galicka, A (2002). "Mutations in type I collagen genes resulting in osteogenesis imperfecta in humans". Acta biochimica ... "Ehlers-Danlos syndrome and type III collagen abnormalities: a variable clinical spectrum". Clinical Genetics 53 (6): 440-446. ... Type 2: brusk (hovedkomponent). Sykdommer[rediger , rediger kilde]. Ett tusen mutasjoner er blitt identifisert i tolv av mer ...
The molecular basis for thin basement membrane disease has yet to be elucidated fully; however, defects in type IV collagen ... defects in the gene encoding the a4 chain of type IV collagen have been reported in some families. Overall, most people with ... GeneReviews/NCBI/NIH/UW entry on Collagen IV-Related Nephropathies (Alport Syndrome and Thin Basement Membrane Nephropathy). ...
... within the human COL7A1 gene encoding the protein type VII collagen (collagen VII).[11] DEB-causing mutations can be either ... Type VII collagen mutations and phenotype-genotype correlations in the dystrophic subtypes". Journal of Medical Genetics. 44 (3 ... There are 54 known keratin genes-of which 28 belong to the type I intermediate filament genes and 26 to type II-which work as ... Over 300 mutations have been identified in this condition.[7] They have been classified into the following types:[8][9]:596 ...
Leitinger B, Kwan AP (2006). "The discoidin domain receptor DDR2 is a receptor for type X collagen". Matrix Biol. 25 (6): 355- ... protein tyrosine kinase collagen receptor activity. • protein tyrosine kinase activity. • ATP binding. • collagen binding. ... collagen-activated tyrosine kinase receptor signaling pathway. • ossification. • phosphorylation. • collagen fibril ... "Discoidin domain receptor 2 interacts with Src and Shc following its activation by type I collagen". J. Biol. Chem. 277 (21): ...
COL17A1 is collagen. Specifically type XVII, alpha 1. This may play a role in overall protein structure. PRDM16 binds to DNA ... This type of conclusion will require further information. Not enough consensus exists as to where in the body SMIM23 is ... The closest relatives to humans with the SMIM23 gene were in primates so two types of monkeys were picked which diverged around ... The same kind of investigation of protein localization in other types of species returned conflicting results. Many programs ...
Svensson L, Närlid I, Oldberg A (Mar 2000). "Fibromodulin and lumican bind to the same region on collagen type I fibrils". FEBS ... This enables it bind to collagen molecules within a collagen fibril, thus helping keep adjacent fibrils apart.[9] ... fibrillar collagen trimer. • lysosomal lumen. • Golgi lumen. • extracellular exosome. • extracellular space. • extracellular ... collagen binding. • extracellular matrix structural constituent. • protein binding. Cellular component. • extracellular matrix ...
COL11A1: collagen, type XI, alpha 1. *CPT2: carnitine palmitoyltransferase II. *CRYZ: Crystallin zeta ... This type of ideogram is generally used in genome browsers (e.g. Ensembl, UCSC Genome Browser). ... FRA1J encoding protein Fragile site, 5-azacytidine type, common, fra(1)(q12) ... This type of ideogram represents actual relative band length observed under a microscope at the different moments during the ...
2007, (Type species of the genus).;: Greek noun amulon, starch; New Latin adjective lyticus -a -um (from Greek adjective ... 2007, ; New Latin noun collagenum, collagen; Latin adjective marinus -a -um, of the sea, marine; New Latin feminine gender ... the source of the type strain), Kenya.) Bacterial taxonomy Microbiology Classification of Genera AC entry in LPSN [Euzéby, J.P ...
The COL11A2 gene is responsible for providing instructions on making one component of the type XI collagen. Type XI collagen is ... which codes for the α2 strand of collagen type XI. It is a collagenopathy, types II and XI disorder. It causes facial ... The mutation of COL11A2 in Weissenbacher-Zweymüller syndrome disrupts the assembly of the type XI collagen molecules. The ... Collagen is found in bone. It is also found in cartilage that makes up most of the skeleton during early development. ...
... s can also be classified functionally according to the type and degree of movement they allow:[1][9] Joint movements are ... fibrous joint - joined by dense regular connective tissue that is rich in collagen fibers [6] ... There are two types: primary cartilaginous joints composed of hyaline cartilage, and secondary cartilaginous joints composed of ... Types of joints based upon their structure (L to R): Cartilaginous joint, Fibrous joint, and Synovial joint. ...
Abnormally shaped ends of one or more bones at a joint A Type 1 collagen or other connective tissue defect (as found in Ehlers- ... For example: Typing can reduce pain from writing. Voice control software or a more ergonomic keyboard can reduce pain from ... Female sex hormones alter collagen proteins. Women are generally more supple just before a period and even more so in the ... The dermatosparaxis and kyphoscoliosis types of EDS and some cases of the classic and hypermobility forms, are inherited in an ...
Research into synthetic collagen is ongoing; as of 2011, partial success has been achieved in replicating collagen's structure ... Probably best known as a gelling agent in cooking, different types and grades of gelatin are used in a wide range of food and ... It has been suggested that Hydrolyzed collagen be merged into this article. (Discuss) Proposed since July 2018. ... "Type A & B Process Definition". Vyse Gelatin Company. 26 October 2009. Archived from the original on 1 March 2015. Retrieved 16 ...
Each type of connective tissue in animals has a type of ECM: collagen fibers and bone mineral comprise the ECM of bone tissue; ... CollagenEdit. Collagens are the most abundant protein in the ECM. In fact, collagen is the most abundant protein in the human ... The collagen can be divided into several families according to the types of structure they form: *Fibrillar (Type I, II, III, V ... Other (Type VI, VII, XIII). ElastinEdit. Elastins, in contrast to collagens, give elasticity to tissues, allowing them to ...
Collagen, type XXIV, alpha 1 is a protein that in humans is encoded by the COL24A1 gene. Model organisms have been used in the ... Collagen, type XXIV, alpha 1". Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of ...
There are multiple types of collagen: Type I (comprising skin, tendons and ligaments, vasculature and organs, as well as teeth ... Several types of protein based, nanosized fibers are being used in nanocomposites. These include collagen, cellulose, chitin ... and bone); Type II (a component in cartilage); Type III (often found in reticular fibers); and others. Collagen has a ... Additionally secondary processing of collagen sources to obtain sufficient purity collagen micro fibrils adds a degree of cost ...
Among the many types of collagens, only the fibrillar and the basement membrane (type IV) collagens have been found in the ... Type II and type XI collagens compose the fibrils present in cartilage. These can be distinguished from collagens located in ... coding for collagen type IV which is a diagnostic feature of the basal lamina It has also been found that 29 types of collagen ... Different types of collagen have been found in all multicellular organisms, including sponges. It has been found that sponges ...
Bornstein P, Kyriakides TR, Yang Z, Armstrong LC, Birk DE (Dec 2000). "Thrombospondin 2 modulates collagen fibrillogenesis and ... "Entrez Gene: THBS2 thrombospondin 2". Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix ... Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of ... "Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen ...
Several types of catenins work with N-cadherins to play an important role in learning and memory (For full article, see ... Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR (October 2011). "A role for collagen XXIII in cancer cell ... For instance, higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened ... levels of collagen helped facilitate adhesions and anchorage-independent cell growth and provided evidence of collagen XXIII's ...
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C- ... Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen".[citation needed] Collagen IV ... type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 ... Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase?". Alcoholism: ...
This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha ... Collagen, type VII, alpha 1 has been shown to interact with Laminin 5 and Fibronectin. Collagen GRCh38: Ensembl release 89: ... of type VII collagen is amino-terminal and chimeric. Homology to cartilage matrix protein, the type III domains of fibronectin ... "Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin". The ...
Retrieved from "https://en.wikipedia.org/w/index.php?title=Collagen,_type_XX,_alpha_1&oldid=705418915" ...
Collagen type VI myopathies.. Bushby KM1, Collins J, Hicks D.. Author information. 1. Institute of Genetic Medicine, Newcastle ... Mutations in each of the three collagen VI genes COL6A1, COL6A2 and COL6A3 cause two main types of muscle disorders: Ullrich ... Publication type, MeSH terms, Substances, Supplementary concepts, Grant support. Publication type. *Review ... Collagen VI is an important component of the extracellular matrix which forms a microfibrillar network that is found in close ...
I report a series of studies targeted at elucidating mechanisms of proteostasis for collagen type-1, the most abundant collagen ... Misfolding collagen variants cause disease, including osteogenesis imperfecta in the case of collagen-I variants. The origins ... Despite decades of work, however, the mechanisms of collagen folding remain poorly understood, and collagen quality control is ... The folding, quality control, and secretion of collagen presents a significant challenge to collagen-producing cells. Each ...
About 47% of these are collagen, 18% are anti-aging, and 12% are animal extract. A wide variety of collagen type ii options are ... chicken collagen type ii amino collagen c collagen granule firm up collagen cartilage collagen us collagen softgel oem collagen ... Raw material hydrolyzed collagen type 2 cas 9064-67-9 fish collagen powder type II hydrolyzed collagen type II powder ... Tags: Undenatured Collagen Type Ii , Undenatured Collagen Type 2 , Collagen Type 2 Undenatured ...
Healthy Origins, Natural, UC-II with Undenatured Type II Collagen, 40 mg, 120 Veggie Caps. 6 ... Now Foods, UC-II Joint Health, Undenatured Type II Collagen, 120 Veg Capsules. 86 ... Healthy Origins, Natural, UC-II with Undenatured Type II Collagen, 40 mg, 60 Veggie Caps. 3 ... Life Extension, Bio-Collagen with Patented UC-II, 40 mg, 60 Small Caps. 20 ...
Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. Here the D is approximately 67 nm and ... These form the most abundant collagens in vertebrates. ... There are 29 genetically distinct collagens present in animal ... Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen ... These form the most abundant collagens in vertebrates.. Collagen types I - V. *Type I collagen is found throughout the body ...
Collagens constitute nearly 30% of all proteins in our body (1). Among the 29 collagen types, type IV collagen is a major and ... collagen types I, II, and III) and networks (collagen types IV and VI) (1). Proper posttranslational modifications of collagen ... C and D) Presence of type IV collagen in both P3H2-null and control embryos at E6 (green) is shown. colIV, type IV collagen. (E ... Type I collagen used for SPR experiments was extracted from mouse skin as previously described (6). Type IV collagen extracted ...
... dginn at olivet.edu dginn at olivet.edu Sun Jun 9 23:37:26 EST 1996 *Previous message: ... Greetings, I am looking for a plasmid probe with a cDNA sequence for Rat Type I collagen gene [alpha1(I) and/or alpha2(I)]. ... Previous message: Rat Type I collagen cDNA probe needed *Next message: Rat Type I collagen cDNA probe needed ...
alpha-1(IX) collagen chain. cartilage-specific short collagen. collagen IX, alpha-1 polypeptide. collagen, type IX, alpha 1. ... Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have ... COL9A1 collagen type IX alpha 1 chain [Homo sapiens] COL9A1 collagen type IX alpha 1 chain [Homo sapiens]. Gene ID:1297 ... Type IX collagen interacts with fibronectin providing an important molecular bridge in articular cartilage Title: Type IX ...
COL18A1 collagen type XVIII alpha 1 chain [Homo sapiens] COL18A1 collagen type XVIII alpha 1 chain [Homo sapiens]. Gene ID: ... collagen alpha-1(XVIII) chain isoform 1 preproprotein. collagen, type XVIII, alpha 1. endostatin. multi-functional protein MFP ... CRD_Collagen_XVIII; Cysteine-rich domain of the variant 3 of collagen XVIII (V3C18 ). pfam01391. Location:1057 → 1107. Collagen ... This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix ...
collagen alpha-2(VIII) chain. Names. collagen VIII, alpha-2 polypeptide. collagen, type VIII, alpha 2. endothelial collagen. ... COL8A2 collagen type VIII alpha 2 chain [Homo sapiens] COL8A2 collagen type VIII alpha 2 chain [Homo sapiens]. Gene ID:1296 ... Collagen; Collagen triple helix repeat (20 copies). * NM_005202.3 → NP_005193.1 collagen alpha-2(VIII) chain isoform 1 ... Collagen formation, organism-specific biosystem (from REACTOME) Collagen formation, organism-specific biosystemCollagen is a ...
... mainly type II collagen), the outer elastin layer (OEL), and a layer of type I collagen fiber bundles (cI). In the col1a2−/− ... into the type I collagen triple helix. However, to obtain a full understanding of zebrafish type I collagen, the exact trimer ... Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies. Charlotte Gistelinck, Ronald Y. Kwon, ... Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies. Charlotte Gistelinck, Ronald Y. Kwon, ...
The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance ... The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance ... This chapter outlines several methods to assess the in vitro production of type I collagen that are employed in our laboratory ... Type I collagen Western immunoblot real-time PCR nuclear run-on assay ...
b-2Cool®​ is a natural ingredient supplying native (undenatured) type II collagen, whose efficacy in joint health improvement ... Discover b-2Cool, Bioibericas native type II collagen. Published 07-Nov-2017. ... is able to modulate the immune response against endogenous type II collagen in the cartilage. ...
collagen type IV, isoform A. D. melanogaster. 51.5. 483. NP_001116702.1 * Conserved domains (CDD) * * Gene summary * * Protein ... Collagen, type IV, alpha 4 (COL4A4). Human protein-coding gene COL4A4. Represented by 83 ESTs from 50 cDNA libraries. ... collagen alpha-5(IV) chain precursor. D. rerio. 49.9. 1626. NP_510664.1 * Conserved domains (CDD) * * Gene summary * * Protein ... PREDICTED: collagen alpha-4(IV) chain. P. troglodytes. 98.8. 1689. XP_003908072.1 * Conserved domains (CDD) * * Gene summary * ...
COL18A1, KNO, KNO1, KS, Collagen, type XVIII, alpha 1, collagen type XVIII alpha 1, collagen type XVIII alpha 1 chain. ... This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix ... 2002). "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are ... "Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to ...
COL18A1 collagen type XVIII alpha 1 chain [Canis lupus familiaris] COL18A1 collagen type XVIII alpha 1 chain [Canis lupus ... LOW QUALITY PROTEIN: collagen alpha-1(XVIII) chain. Names. collagen, type XVIII, alpha 1. endostatin. ... collagen type XVIII alpha 1 chainprovided by VGNC. Primary source. VGNC:VGNC:49781 See related. Ensembl:ENSCAFG00000011817 Gene ... COL18A1 collagen type XVIII alpha 1 chain [ Canis lupus familiaris (dog) ] Gene ID: 100687767, updated on 26-Sep-2018 ...
Collagen Type 4-related Nephropathies: From Alport to Thin Membrane Nephropathy. A Series of Cases Treated With Angiotensin ... Patients with Collagen type 4 nephropathies and proteinuria followed in Pediatric Nephrology Unit of Instituto da Criança - ... Background: Collagen IV-related nephropathies can lead to End Stage Renal Disease. Experimental studies have shown renin ... Methods: This is a retrospective study of patients with Collagen IV-related nephropathies and proteinuria treated with ...
Compare collagen type XXIV alpha 1 Biomolecules from leading suppliers on Biocompare. View specifications, prices, citations, ... Your search returned 1 collagen type XXIV alpha 1 Biomolecules across 1 supplier. ... Strong, native & highly biocompatible - introducing next generation collagen fibers for the development of novel therapies in ...
Compare collagen type XXV alpha 1 Biomolecules from leading suppliers on Biocompare. View specifications, prices, citations, ... Transient overexpression lysate of collagen, type XXV, alpha 1 (COL25A1), transcript variant 1 ... Your search returned 5 collagen type XXV alpha 1 Biomolecules across 3 suppliers. ... Strong, native & highly biocompatible - introducing next generation collagen fibers for the development of novel therapies in ...
... when adherent to type V collagen. Yet, staurosporine induced Akt and Erk activation on H295R cells: the adhesion on type V ... Adrenocortical cancer Type V collagen Apoptosis Staurosporine This is a preview of subscription content, log in to check access ... Luparello C, David F, Campisi G, Sirchia R. T47-D cells and type V collagen: a model for the study of apoptotic gene expression ... Luparello C, Sirchia R, Longo A. Type V collagen and protein kinase Cη down-regulation in 8701-BC breast cancer cells. Mol ...
Ullrich scleroatonic muscular dystrophy is caused by recessive mutations in collagen type VI. Olga Camacho Vanegas, Enrico ... Ullrich scleroatonic muscular dystrophy is caused by recessive mutations in collagen type VI ... The α1(VI) and α2(VI) collagen chains comigrated at 140 kDa, whereas the α3(VI) collagen chains migrated at 260-300 kDa. ... Ullrich scleroatonic muscular dystrophy is caused by recessive mutations in collagen type VI ...
The alpha2(IV) and alpha1(IV) collagens are structurally very similar to one another, and to vertebrate type IV collagens. In ... viking: identification and characterization of a second type IV collagen in Drosophila.. Yasothornsrikul S1, Davis WJ, Cramer G ... This analysis has determined that viking encodes a collagen type IV gene, alpha2(IV). The viking locus is located adjacent to ... This work also provides the foundation for a more complete genetic dissection of collagen type IV molecules and their ...
  • The measurement of α1(I) collagen mRNA levels using real-time polymerase chain reaction is then outlined. (springer.com)
  • Addition of 50 ng/ml insulin-like growth factor-I (IGF-I) to a deficient serum lot significantly enhanced its ability to induce aggrecan and type II collagen mRNA. (nih.gov)
  • Type I collagen production is inhibited by the inability of the altered procollagen strands to associate and form the triple-stranded, ropelike structure of mature collagen. (wikipedia.org)
  • The expression of procollagen 1 C-terminal peptide (PICP) and collagen type 1 C-terminal telopeptide (ICTP), two major by-products in the synthesis and degradation of collagen, was shown to be positively correlated with inflammatory mediator levels in previous studies. (dovepress.com)
  • This chapter outlines several methods to assess the in vitro production of type I collagen that are employed in our laboratory. (springer.com)
  • To investigate the swelling ratio and the in vitro degradation of the collagen scaffold, the tests were also carried out by immersion of the scaffolds in a PBS solution or digestion in a type I collagenase respectively. (springer.com)
  • Under small shear strains, {\em in vitro} collagen gels exhibit strain-stiffening while maintaining overall network integrity. (aps.org)
  • Type IV collagen, an important component of the basement membrane, is highly expressed by pancreatic cancer cells both in vivo and in vitro. (diva-portal.org)
  • Super Collagen™ is enzymatically hydrolyzed, providing an amino acid ratio with a low molecular weight for maximum bioavailability and utilization by the body. (vitaminworld.com)
  • Super Collagen™ is neutral in taste and is specifically formulated in an easy to take powder form. (vitaminworld.com)
  • Directions: As a daily dietary supplement, dissolve one scoop of Super Collagen™ Dietary Supplement with one spoon of water or orange juice. (vitaminworld.com)
  • Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. (wikipedia.org)
  • The large non-collagenous domain (NC-1) of type VII collagen is amino-terminal and chimeric. (wikipedia.org)
  • First, I explore the folding and assembly of the critically important C-terminal, globular propeptide domains of collagen-I. My data demonstrate the importance of a single amino acid in the globular C-terminal domain that regulates the oligomerization propensity of 30 kDa C-propeptide monomers. (mit.edu)
  • Ultimately, I show that this single amino acid guides the assembly of the C-propeptides of all the fibrillar collagens. (mit.edu)
  • We describe Western immunoblotting of intact α1(I) collagen using antibodies directed to α1(I) collagen amino and carboxyl propeptides. (springer.com)
  • Furthermore, possible recognition sequences for furin (a major physiological protease) cleavage sites have been found in both amino-terminal NC1 domain and carboxyl-terminal NC4 domain of each one of these collagens. (wikipedia.org)
  • Each type IV collagen contains a long triple-helical collagenous domain flanked by a short 7S domain of 25 amino acids and a globular non-collagenous C4 domain of ~230 amino acids at the N and C terminus, respectively. (wikipedia.org)
  • DESIGN AND METHODS: A fragment unique to type V collagen and generated by both MMP-2/9 cleaved at the amino acid position 1317 (C5M) was selected for ELISA development. (biomedsearch.com)
  • Parallels the amino acid structure of our own body s collagen type II. (nutritiongeeks.com)
  • The percentage and molecular weight of each amino acid is different than those found in Type I & III. (nutritiongeeks.com)
  • The amino acid content of hydrolyzed collagen is the same as collagen. (wikipedia.org)
  • Hydrolyzed collagen contains 19 amino acids, predominantly glycine, proline and hydroxyproline, which together represent around 50% of the total amino acid content. (wikipedia.org)