A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.
An autoimmune disease of the KIDNEY and the LUNG. It is characterized by the presence of circulating autoantibodies targeting the epitopes in the non-collagenous domains of COLLAGEN TYPE IV in the basement membranes of kidney glomeruli (KIDNEY GLOMERULUS) and lung alveoli (PULMONARY ALVEOLI), and the subsequent destruction of these basement membranes. Clinical features include pulmonary alveolar hemorrhage and glomerulonephritis.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.
A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.
Hearing loss resulting from damage to the COCHLEA and the sensorineural elements which lie internally beyond the oval and round windows. These elements include the AUDITORY NERVE and its connections in the BRAINSTEM.
Expectoration or spitting of blood originating from any part of the RESPIRATORY TRACT, usually from hemorrhage in the lung parenchyma (PULMONARY ALVEOLI) and the BRONCHIAL ARTERIES.
A non-fibrillar collagen involved in anchoring the epidermal BASEMENT MEMBRANE to underlying tissue. It is a homotrimer comprised of C-terminal and N-terminal globular domains connected by a central triple-helical region.
Form of epidermolysis bullosa characterized by trauma-induced, subepidermal blistering with no family history of the disease. Direct immunofluorescence shows IMMUNOGLOBULIN G deposited at the dermo-epidermal junction.
Form of epidermolysis bullosa characterized by atrophy of blistered areas, severe scarring, and nail changes. It is most often present at birth or in early infancy and occurs in both autosomal dominant and recessive forms. All forms of dystrophic epidermolysis bullosa result from mutations in COLLAGEN TYPE VII, a major component fibrils of BASEMENT MEMBRANE and EPIDERMIS.
Group of genetically determined disorders characterized by the blistering of skin and mucosae. There are four major forms: acquired, simple, junctional, and dystrophic. Each of the latter three has several varieties.
Visible accumulations of fluid within or beneath the epidermis.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
The measure of the level of heat of a human or animal.
A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. Although they take part in the assembly process, molecular chaperones are not components of the final structures.
Disorders caused by imbalances in the protein homeostasis network - synthesis, folding, and transport of proteins; post-translational modifications; and degradation or clearance of misfolded proteins.
A system of cisternae in the CYTOPLASM of many cells. In places the endoplasmic reticulum is continuous with the plasma membrane (CELL MEMBRANE) or outer membrane of the nuclear envelope. If the outer surfaces of the endoplasmic reticulum membranes are coated with ribosomes, the endoplasmic reticulum is said to be rough-surfaced (ENDOPLASMIC RETICULUM, ROUGH); otherwise it is said to be smooth-surfaced (ENDOPLASMIC RETICULUM, SMOOTH). (King & Stansfield, A Dictionary of Genetics, 4th ed)
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Exclusive legal rights or privileges applied to inventions, plants, etc.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
An object or a situation that can serve to reinforce a response, to satisfy a motive, or to afford pleasure.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
A non-fibrillar collagen found in BASEMENT MEMBRANE. The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage.
Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.
A layer of the cornea. It is the basal lamina of the CORNEAL ENDOTHELIUM (from which it is secreted) separating it from the CORNEAL STROMA. It is a homogeneous structure composed of fine collagenous filaments, and slowly increases in thickness with age.
A proto-oncogene protein and member of the Wnt family of proteins. It is frequently up-regulated in human GASTRIC CANCER and is a tumor marker (BIOMARKERS, TUMOR) of gastric and COLORECTAL CANCER.
The mechanical process of cooling.
Insurance designed to compensate persons who lose wages because of illness or injury; insurance providing periodic payments that partially replace lost wages, salary, or other income when the insured is unable to work because of illness, injury, or disease. Individual and group disability insurance are two types of such coverage. (From Facts on File Dictionary of Health Care Management, 1988, p207)
An independent agency within the Executive Branch of the United States Government. It administers a national social insurance program whereby employees, employers, and the self-employed pay contributions into pooled trust funds. Part of the contributions go into a separate hospital insurance trust fund for workers at age 65 to provide help with medical expenses. Other programs include the supplemental social security income program for the aged, blind, and disabled and the Old Age Survivors and Disability Insurance Program. It became an independent agency March 31, 1995. It had previously been part of the Department of Health, Education, and Welfare, later the Department of Health and Human Services. (From United States Government Manual, 1994-95)
Government sponsored social insurance programs.
A plant genus of the family LINACEAE that is cultivated for its fiber (manufactured into linen cloth). It contains a trypsin inhibitor and the seed is the source of LINSEED OIL.
The fixed oil obtained from the dried ripe seed of linseed, Linum usitatissimum (L. Linaceae). It is used as an emollient in liniments, pastes, and medicinal soaps, and in veterinary medicine as a laxative. It is also called flaxseed oil. (Dorland, 28th ed)
Ratings of the characteristics of food including flavor, appearance, nutritional content, and the amount of microbial and chemical contamination.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
A type of CARTILAGE whose matrix contains ELASTIC FIBERS and elastic lamellae, in addition to the normal components of HYALINE CARTILAGE matrix. Elastic cartilage is found in the EXTERNAL EAR; EUSTACHIAN TUBE; EPIGLOTTIS; and LARYNX.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.
Domesticated birds raised for food. It typically includes CHICKENS; TURKEYS, DUCKS; GEESE; and others.
Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
Genes that influence the PHENOTYPE only in the homozygous state.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
A complex of closely related aminoglycosides obtained from MICROMONOSPORA purpurea and related species. They are broad-spectrum antibiotics, but may cause ear and kidney damage. They act to inhibit PROTEIN BIOSYNTHESIS.
Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.
Study of intracellular distribution of chemicals, reaction sites, enzymes, etc., by means of staining reactions, radioactive isotope uptake, selective metal distribution in electron microscopy, or other methods.
Fibrous bands or cords of CONNECTIVE TISSUE at the ends of SKELETAL MUSCLE FIBERS that serve to attach the MUSCLES to bones and other structures.
A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.
COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.

Biosynthetic processing of the pro-alpha 1(V)2pro-alpha 2(V) collagen heterotrimer by bone morphogenetic protein-1 and furin-like proprotein convertases. (1/105)

The low abundance fibrillar collagen type V is incorporated into and regulates the diameters of type I collagen fibrils. Bone morphogenetic protein-1 (BMP-1) is a metalloprotease that plays key roles in regulating formation of vertebrate extracellular matrix; it cleaves the C-propeptides of the major fibrillar procollagens I-III and processes precursors to produce the mature forms of the cross-linking enzyme prolysyl oxidase, the proteoglycan biglycan, and the basement membrane protein laminin 5. Here we have successfully produced recombinant pro-alpha1(V)(2)pro-alpha2(V) heterotrimers, and we have used these to characterize biosynthetic processing of the most prevalent in vivo form of type V procollagen. In addition, we have compared the processing of endogenous pro-alpha1(V) chains by wild type mouse embryo fibroblasts and by fibroblasts derived from embryos doubly homozygous null for the Bmp-1 gene and for a gene encoding the closely related metalloprotease mammalian Tolloid-like 1. Together, results presented herein indicate that within pro-alpha1(V)(2)pro-alpha2(V) heterotrimers, pro-alpha1(V) N-propeptides and pro-alpha2(V) C-propeptides are processed by BMP-1-like enzymes, and pro-alpha1(V) C-propeptides are processed by furin-like proprotein convertases in vivo.  (+info)

Schwann cell adhesion to a novel heparan sulfate binding site in the N-terminal domain of alpha 4 type V collagen is mediated by syndecan-3. (2/105)

Previously we reported that type V collagen synthesized by Schwann cells inhibits the outgrowth of axons from rat embryo dorsal root ganglion neurons but promotes Schwann cell migration (Chernousov, M. A., Stahl, R. C., and Carey, D. J. (2001) J. Neurosci. 21, 6125-6135). Analysis of Schwann cell adhesion and spreading on dishes coated with various type V collagen domains revealed that Schwann cells adhered effectively only to the non-collagenous N-terminal domain (NTD) of the alpha4(V) collagen chain. Schwann cell adhesion to alpha4(V)-NTD induced actin cytoskeleton assembly, tyrosine phosphorylation, and activation of the Erk1/Erk2 protein kinases. Adhesion to alpha4(V)-NTD is cell type-specific because rat fibroblasts failed to adhere to dishes coated with this polypeptide. Schwann cell adhesion and spreading on alpha4(V)-NTD was strongly inhibited by soluble heparin (IC(50) approximately 30 ng/ml) but not by chondroitin sulfate. Analysis of the heparin binding activities of a series of recombinant alpha4(V)-NTD fragments and deletion mutants identified a highly basic region (not present in other type V collagen NTD) as the site responsible for high affinity heparin binding. Schwann cells adhered poorly to dishes coated with alpha4(V)-NTD that lacked the heparin binding site and failed to spread or assemble organized actin-cytoskeletal structures. Soluble alpha4(V)-NTD polypeptide that contained the heparin binding site inhibited spreading of Schwann cells on dishes coated with alpha4(V)-NTD. Affinity chromatography of Schwann cell detergent extracts on a column of immobilized alpha4(V)-NTD resulted in the isolation of syndecan-3, a transmembrane heparan sulfate proteoglycan. Together, these results suggest that Schwann cells bind to collagen type V via syndecan-3-dependent binding to a novel high affinity heparin binding site in the alpha4(V)-NTD.  (+info)

Type V collagen distribution in liver is reconstructed in coculture system of hepatocytes and stellate cells; the possible functions of type V collagen in liver under normal and pathological conditions. (3/105)

The contents of type I, type III and type V collagen and the collagen type specific distributions in liver under normal and cirrhotic conditions were examined. In CCl4 injected rat, the increasing amount of type V collagen was a specific event during the progression of cirrhosis. In normal liver, immunohistochemical observation showed that type V collagen was localized on the fine fibrils, while type I was localized on the thick fibril. Type V collagen was partially colocalized with type IV collagen. In the cirrhotic liver, type V collagen was localized on the margin of the thick fibrous septa along with type IV collagen. Type I collagen existed in the core region of fibrous septa where the stellate cells were prominent. To elucidate the mechanism of the type specific deposition of collagen in the liver, we constructed a coculture system using both stellate cells and hepatocytes. In this system, type V collagen was mainly deposited on hepatocyte colonies not on stellate cells, while type I collagen fibrils were localized on stellate cells. The spatial positioning of type I and type V collagens in vitro was similar to that in the liver. In the cell adhesion assay, the adhesion of stellate cells to type V collagen was poorer than that of the hepatocytes. The collagen type-specific affinity of the stellate cells and hepatocytes may explain the specific localization of type V collagen in the liver and coculture system. These results suggested that the functions of type V collagen are not only to connect type IV collagen with type I collagen fibril, but also to protect the parenchyma from excess type I collagen deposition produced by stellate cells under pathological conditions.  (+info)

Evidence for immune responses to a self-antigen in lung transplantation: role of type V collagen-specific T cells in the pathogenesis of lung allograft rejection. (4/105)

We have reported that lung allograft rejection involves an immune response to a native protein in the lung, type V collagen (col(V)), and that col(V)-induced oral tolerance prevented acute and chronic rejection. In support of these findings col(V) fragments were detected in allografts during rejection, but not in normal lungs. The purpose of the current study was to isolate and characterize col(V)-specific allograft-infiltrating T cells and to determine their contribution to the rejection response in vivo. Two col(V)-specific T cell lines, LT1 and LT3, were isolated from F344 (RT1(lv1)) rat lung allografts during rejection that occurred after transplantation into WKY (RT1(l)) recipients. Both cell lines, but not normal lung lymphocytes, proliferated in response to col(V). Neither LT1 nor LT3 proliferated in response to alloantigens. LT1 and LT3 were CD4(+)CD25(-) and produced IFN-gamma in response to col(V). Compared with normal CD4(+) T cells, both cell lines expressed a limited V-beta TCR repertoire. Each cell strongly expressed V-beta 9 and 16, but differed in expression of other V-betas. Adoptive transfer of each cell line did not induce pathology in lungs of normal WKY rats. In contrast, adoptive transfer of LT1, but not LT3, caused marked peribronchiolar and perivascular inflammation in isograft (WKY) lungs and abrogated col(V)-induced oral tolerance to allograft (F344) lungs. Collectively, these data show that lung allograft rejection involves both allo- and autoimmune responses, and graft destruction that occurs during the rejection response may expose allograft-infiltrating T cells to potentially antigenic epitopes in col(V).  (+info)

Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. (5/105)

Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the protein or the expression of one COL5A1 allele. We identified a novel splice-acceptor mutation (IVS4-2A-->G) in the N-propeptide-encoding region of COL5A1, in one patient with EDS type I. The outcome of this mutation was complex: In the major product, both exons 5 and 6 were skipped; other products included a small amount in which only exon 5 was skipped and an even smaller amount in which cryptic acceptor sites within exon 5 were used. All products were in frame. Pro-alpha1(V) chains with abnormal N-propeptides were secreted and were incorporated into extracellular matrix, and the mutation resulted in dramatic alterations in collagen fibril structure. The two-exon skip occurred in transcripts in which intron 5 was removed rapidly relative to introns 4 and 6, leaving a large (270 nt) composite exon that can be skipped in its entirety. The transcripts in which only exon 5 was skipped were derived from those in which intron 6 was removed prior to intron 5. The use of cryptic acceptor sites in exon 5 occurred in transcripts in which intron 4 was removed subsequent to introns 5 and 6. These findings suggest that the order of intron removal plays an important role in the outcome of splice-site mutations and provide a model that explains why multiple products derive from a mutation at a single splice site.  (+info)

Release of biologically active TGF-beta1 by alveolar epithelial cells results in pulmonary fibrosis. (6/105)

Idiopathic pulmonary fibrosis (IPF) is a progressive fatal fibrotic lung disease. Transforming growth factor (TGF)-beta1 is present in a biologically active conformation in the epithelial cells lining lesions with advanced IPF. To determine the role of aberrant expression of biologically active TGF-beta1 by alveolar epithelial cells (AECs), the AECs of explanted normal rat lungs were transfected with the TGF-beta1 gene using the retrovirus pMX-L-s223,225-TGF-beta1. In situ hybridization using a digoxigenin-labeled cDNA of the puromycin resistance gene contained in the pMX demonstrated that pMX-L-s233,225-TGF-beta1 was selectively transfected into AECs of the explants. Conditioned media overlying explants obtained 7 days after being treated with pMX-L-s223,225-TGF-beta1 contained 14.5 +/- 3.15 pg/ml of active TGF-beta1. With the use of Masson's trichrome staining of explant sections obtained 14 days after transfection, there were lesions similar to those in IPF, characterized by type II AEC hyperplasia, interstitial thickening, extensive increase in interstitial and subepithelial collagen, an increase in the number of fibroblasts, and areas resembling fibroblast buds. Collagens I, III, IV, and V and fibronectin were increased in explants treated with pMX-L-s223,225-TGF-beta1. The findings in the current study suggest that IPF may be a disorder of epithelial cells and not inflammatory cells.  (+info)

Differential expression of Smad7 transcripts identifies the CD4+CD45RChigh regulatory T cells that mediate type V collagen-induced tolerance to lung allografts. (7/105)

Regulatory T cells (Tregs) induced by oral tolerance may suppress immunity by production of TGF-beta that could also enhance Treg activity. However, all cells that are phenotypically Tregs in rats (CD4(+)CD45RC(high)-RC(high)) may not have regulatory function. Because Smad7 expression in T cells is associated with inflammation and autoimmunity, then lack of Smad7 may identify those cells that function as Tregs. We reported that feeding type V collagen (col(V)) to WKY rats (RT1(l)) induces oral tolerance to lung allografts (F344-RT1(lvl)) by T cells that produce TGF-beta. The purpose of the current study was to identify the Tregs that mediate col(V)-induced tolerance, and determine Smad7 expression in these cells. RC(high) cells from tolerant rats were unresponsive to allogeneic stimulation and abrogated rejection after adoptive transfer. In contrast, CD4(+)CD45RC(low) (RC(low)) cells from tolerant rats and RC(high) or RC(low) cells from normal rats or untreated allograft recipients proliferated vigorously in response to donor Ags, and did not suppress rejection after adoptive transfer. TGF-beta enhanced proliferation in response to col(V) presented to tolerant RC(high), but not other cells. In contrast to other cells, only RC(high) cells from tolerant rats did not express Smad7. Collectively, these data show that the Tregs that mediate col(V)-induced tolerance to lung allografts do not express SMAD7 and, therefore, are permissive to TGF-beta-mediated signaling.  (+info)

Role of 12-lipoxygenase in the stimulation of p38 mitogen-activated protein kinase and collagen alpha5(IV) in experimental diabetic nephropathy and in glucose-stimulated podocytes. (8/105)

The 12-lipoxygenase (12-LO) pathway of arachidonic acid metabolism is implicated in extracellular matrix (ECM) synthesis, but its role in podocytes has not been studied. This study tested whether 12-LO induction by diabetes or by high glucose (HG) in cultured podocytes alters glomerular basement membrane by activating signal transduction pathways culminating in ECM synthesis. Sprague-Dawley rats received an injection of diluent (control [C]) or streptozotocin 65 mg/kg (DM) and were killed at 1 or 4 mo. Glomerular 12-LO mRNA and protein levels were higher in DM than in C glomeruli at 1 and 4 mo, and 12-LO localized predominantly in podocytes. Glomerular p38 mRNA and protein were higher in DM at months 1 and 4, but phospho-p38 mitogen-activated protein (MAPK) was increased only at month 1. Glomerular collagen alpha5(IV)/glutaraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA ratio was increased in DM at month 1 but not at month 4, whereas collagen alpha5(IV) protein was higher at both 1 and 4 mo. Mouse podocytes were cultured in media with 25 mM glucose (HG) with or without the 12-LO inhibitor cinnamyl-3,4-dihydroxy-cyanocinnamate (CDC) or with 5.5 mM glucose + 19.5 mM mannitol (low glucose [LG+M]) for 10 d at 37 degrees C. 12-LO mRNA and protein levels were higher in HG than in LG+M as was the p38 MAPK/GAPDH mRNA ratio. Phospho-p38 MAPK protein but not total p38 MAPK was higher in HG compared with LG+M. Collagen alpha5(IV)/GAPDH mRNA ratio and protein were higher in HG than in LG+M. 12-LO inhibition by CDC decreased HG-induced phospho-p38 MAPK and the phospho-p38/total p38 MAPK ratio, collagen alpha5(IV)/GAPDH mRNA ratio, and collagen alpha5(IV) protein expression. In summary, diabetes in vivo and exposure of podocytes to HG in vitro stimulated 12-LO, p38 MAPK, and collagen alpha5(IV) mRNA and (activated) protein. 12-LO inhibition by CDC diminished the expression of podocyte phospho-p38 MAPK and collagen alpha5(IV) mRNA and protein. These findings implicate 12-LO and the p38 MAPK signaling pathway in the mediation of ECM synthesis by podocytes in diabetes.  (+info)

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Type V collagen may play a role in graft rejection following lung transplants (See Review: Sumpter TL, Wilkes DS. Role of autoimmunity in organ allograft rejection: a focus on immunity to type V collagen in the pathogenesis of lung transplant rejection. Am J Physiol Lung Cell Mol Physiol 2004; 286: L1129-39). It has been shown that oral tolerance induction by oral administration of type V collagen prevents lung allograft rejection in animal models, and is expected to be used for humans. Importantly, it has been reported that patients who were previously sensitized by type V collagen and positive for type V collagen-DTH reactions tend to develop idiopathic pulmonary fibrosis (58.8%, 10/17) compared to patients who were negative for the DTH reaction (15.8%, 6/38) (Bobadilla JL, Love RB, Jankowska-Gan E, Xu Q, et al. Th-17, monokines, collagen type V, and primary graft dysfunction in lung transplantation. Am J Respir Crit Care Med 2008; 177: 660-8).. Type V and Type XI Collagen ...
Manipulations in cell culture and mouse models have demonstrated that reduction of collagen V results in altered fibril structure and matrix assembly. A tissue-dependent role for collagen V in determining mechanical function was recently established, but its role in determining regional properties has not been addressed. The objective of this study was to define the role(s) of collagen V expression in establishing the site-specific properties of the supraspinatus tendon. The insertion and midsubstance of tendons from wild type, heterozygous and tendon/ligament-specific null mice were assessed for crimp morphology, fibril morphology, cell morphology, as well as total collagen and pyridinoline cross-link (PYD) content. Fibril morphology was altered at the midsubstance of both groups with larger, but fewer, fibrils and no change in cell morphology or collagen compared to the wild type controls. In contrast, a significant disruption of fibril assembly was observed at the insertion site of the null ...
Complete information for COL5A3 gene (Protein Coding), Collagen Type V Alpha 3 Chain, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Global Markets Directs, Lung Transplant Rejection - Pipeline Review, H1 2020, provides an overview of the Lung Transplant Rejection pipeline
Collagen V兔多克隆抗体(ab7046)可与小鼠, 牛, 人样本反应并经WB, IP, IHC, ICC/IF, sELISA实验严格验证,被5篇文献引用并得到3个独立的用户反馈。
COL11A2 antibody [GT6410] (collagen, type XI, alpha 2) for WB. Anti-COL11A2 mAb (GTX629739) is tested in Human samples. 100% Ab-Assurance.
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Anti-COL3A1 polyclonal antibody (STJ92388) was developed using a synthesized peptide derived from the N-terminal region of human COL3A1 at AA range: 50-130. This antibody is applicable for use in immunohistochemistry, immunofluorescence, ELISA and immunoc
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The featured research unveils that monitoring of transcription factor Zinc finger and BTB domain-containing protein 7A (ZBTB7A) can be an early predictor of chronic rejection after lung transplant.
Organ transplant patients routinely receive drugs that stop their immune systems from attacking newly implanted hearts, livers, kidneys or lungs, which the body sees as foreign.
Vascular BioSciences, a diversified biomedical company with operations in California and North Carolina, provides disease solutions in order to enhance and prolong human life.
Yamagata, S; Miwa, M; Tanaka, K; and Yamagata, T, Fbj virus-induced osteosarcoma has type v collagen consisting of a, b and c-like chains in addition to type i collagen. (1982). Subject Strain Bibliography 1982. 2868 ...
MMP-20 is predominately a tooth-specific enzyme with a deep catalytic pocket that hydrolyzes type V collagen Academic Article ...
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S9V7-2 CATTGTAACATTAGTAGAACAAAATGGAATGAGACCTTAAGACAGATAGTAGAAAAATTA S9V7-4 CATTGTAACATCAGTGGAGCAAAATGGAATGAGACCTTAAAACAGATAGCTAAAAAATTA S9V7-1 CATTGTAACATCAGTGGAACAAAATGGAATGACACCTTAAAACAGATAGTTGAAAAATTA S9V7-3 CATTGTAACATCAGTGGAACAAAATGGAATGACACCTTAAAACAGATAGTTGAAAAATTA S9V7-5 CATTGTAACATTAGTGGAGCAAAATGGAATGACACCTTAAAACAGATAGTTGGAAAATTA S9V7-8 CATTGTAACATTAGTGGAGCAAAATGGAATGACACCTTAAAACAGATAGCTGGAAAATTA S9V7-7 CATTGTAACATTAGTGGAGCAAAATGGAATGACACCTTAAAACAGATAGTTGGAAAATTA S9V7-9 CATTGTAACATTAGTGGAACAAAATGGAATGACACCTTAAGACAGATAGCTGGAAAATTA S9V7-10 CATTGTAACATTAGTGGAACAAAATGGAATGACACCTTAAGACAGATAGCTGGAAAATTA S9V7-6 CATTGTAACATTAGTGGAGCAAAATGGAATGACACCTTAAGACAGATAGCTGGAAAATTA S9V6-2 CATTGTAACATTAGTGGAGCAAAATGGAATGACACCTTAAGACAGATAGCTGGAAAATTA S9V6-5 CATTGTAACATTAGTGGAGCAAAATGGAATGACACCTTAAAACAGATAGCTGGAAAATTA S9V6-3 CATTGTAACATTAGTGGAGCAAAATGGAATGACACCTTAAAACAGATAGCTGAAAAATTA S9V6-8 CATTGTAACATTAGTGGAGCAAAATGGAATGACACCTTAAGACAGATAGCTGAAAAATTA S9V6-4 ...
6v^2 - 4 + 9v +v^3)/ (v - 4)i am just a little lost can someone explain this to me. thanks. Arrange the polonomial in descending order... v^3-6v^2 +9v -4 Then divide. v-4 !v^3-6v^2 +9v -4 The first term is v^2, so v^2*(v-4) is v^3-4v^2 ...
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Celestoderm V ( စလီဆတိုဒမ်) ဆေးအတွက် အသုံးပြုနည်း ဘေးထွက်ဆိုးကျိုးတွေအပါအဝင် သိချင်တာတွေမှန်သမျှကို သိနိုင်ဖို့အတွက် Hello Sayarwon မှာ ဖတ်ရှုနိုင်ပါတယ်။
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Hello! This is the final part of this information. According to the ezine sent out by Ms. Ruth Ryden, she received this information in the late 1990s. She re-released
അണുസംഖ്യ 23 ആയ മൂലകമാണ് വനേഡിയം. V ആണ് ആവർത്തനപ്പട്ടികയിലെ ഇതിന്റെ പ്രതീകം. ജീവജാലങ്ങളിൽ കണ്ടുവരുന്ന 26 മൂലകങ്ങളിൽ ഒന്നാണ് വനേഡിയം. പ്രകൃതിയിൽ 65ഓളം അയിരുകളിൽ കാണപ്പെടുന്ന ഇത് ലോഹസങ്കരങ്ങളുണ്ടാക്കനായി ഉപയോഗിക്കപ്പെടുന്നു. വടക്കേ അമേരിക്കയിലെ മെക്സിക്കോയിൽ നിന്നും കണ്ടെത്തിയ ഒരു ധാതുവിന്റെ രാസവിശ്ലേഷണത്തിൽ നിന്നും നീൽസ് സെഫ്സ്ട്രോം എന്ന ശാസ്ത്രജ്ഞനാണ് വനേഡിയം ...
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The von Hippel-Lindau tumour suppressor gene (VHL) targets hypoxia inducible factor (HIF)-alpha subunits for ubiquitin dependent proteolysis. To better understand the role of this and other putative pathways of gene regulation in VHL function we subjected mRNA from VHL defective renal carcinoma cells and transfectants re-expressing a wild type VHL allele to differential expression profiling, and analysed VHL target genes for oxygen regulated expression. Among a group of newly identified VHL target genes the majority but not all were regulated by oxygen, indicating that whilst dysregulation of the HIF system makes a dominant contribution to alterations in transcription, VHL has other influences on patterns of gene expression. Genes newly defined as targets of the VHL/hypoxia pathway (conditionally downregulated by VHL in normoxic cells) include aminopeptidase A, collagen type V, alpha 1, cyclin G2, DEC1/Stra13, endothelin 1, low density lipoprotein receptor-related protein 1, MIC2/CD99, and
Respiratory viral infection (RVI) following human lung transplantation (LTx) increases the risk for chronic rejection. We demonstrated that lung transplant recipients (LTxR) with acute and chronic rejection induce exosomes containing HLA and self-antigens (SAg), Kα1Tubulin (Kα1T) and Collagen V (Col-V). We determined whether RVI can induce exosomes containing SAg leading to immune response resulting in rejection and their immunogenicity in mice. Sera from RVI (n=35) and stable LTxR (n=32) were used for exosomes isolation and Abs to SAg. Exosomes were isolated by ultracentrifugation, validated by sucrose cushion and tested for CD-9. SAg, viral antigens for respiratory syncytial virus (RSV), corona virus (CV) and rhino virus (RV) were detected by immunoblot. Exosomes from RVI and stable LTxR were injected subcutaneously (10[micro]g/100[micro]l) into C57BL/6 mice. Sera were analyzed for Abs to SAg by ELISA. Since studies have shown that a primary insult to lung is needed for Abs to SAg to induce ...
The Ehlers-Danlos syndrome (EDS) is a heterogeneous group of inherited connective tissue disorders characterised by skin hyperextensibility, joint hypermobility, easy bruising, and cutaneous fragility. Nine discrete clinical subtypes have been classified. We have investigated the molecular defect in a patient with clinical features of Ehlers-Danlos syndromes types I/II and VII. Electron microscopy of skin tissue indicated abnormal collagen fibrillogenesis with longitudinal sections showing a marked disruption of fibril packing giving very irregular outlines to transverse sections. Analysis of the collagens produced by cultured fibroblasts showed that the type V collagen had a population of alpha 1 (V) chains shorter than normal. Peptide mapping suggested a deletion within the triple helical domain. RTPCR amplification of mRNA covering the whole of this domain of COL5A1 showed a deletion of 54 bp. Although six Gly-X-Y triplets were lost, the essential triplet amino acid sequence and C-propeptide ...
AIM: To obtain some insight into the extracellular matrix in the placenta, changes in the composition of collagens during placental development were investigated. METHODS: Collagen was extracted from placentas (group 1, 25-30 weeks, n = 21; group 2, 31-36 weeks, n = 32; and group 3, 37-41 weeks of gestation, n = 40) and the relative concentrations of various collagens were evaluated by SDS-PAGE. RESULTS: The ratio of the intensity of the alpha 1 (III) band to that of alpha 1 (I) chain collagen in group 3 placentas were lower than those in group 1 placentas. In contrast, the ratio of the intensity of the alpha 1 (V) band to that of alpha 1 (I) chain collagen in group 3 placentas were higher than those in group 1 and group 2 placentas. CONCLUSIONS: These results suggest that type V collagen might play an important role in the function of the placenta and that an increased relative concentration of type V collagen might be closely associated with the development and ageing of the placenta.. ...
Ehlers-Danlos syndrome (EDS) is a group of heritable disorders of connective tissue with skin, ligaments and blood vessels being the main sites affected. The commonest variant (EDS II) exhibits an autosomal dominant mode of inheritance and is characterized by joint hypermobility, cigarette paper scars, lax skin and excessive bruising. As yet no gene has been linked to EDS II, nor has linkage been established to a specific region of the genome. However, several candidate genes encoding proteins of the extracellular matrix have been excluded. Using an intragenic simple sequence repeat polymorphism, we report linkage of the COL5A1 gene, which encodes the alpha 1(V) chain of type V collagen, to EDS II. A maximum LOD score (Zmax) for linkage of 8.3 at theta = 0.00 was generated for a single large pedigree.
Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices.
Tendons are able to withstand the broad range of stresses and strains via their finely tuned composition and structure. In addition, tendons undergo a coordinated set of dynamic responses, specifically collagen uncrimping, re-alignment, sliding and deformation, within the matrix. To date, a complete understanding of the hierarchical structure-function relationships in tendon is lacking. Therefore, the overall goal of this thesis was to measure tendon structure and function in a mouse supraspinatus model of altered structure, and to analyze links between mechanical properties, dynamic processes and composition/structure using a series of statistical analyses. In the studies presented here, we used novel and established methods to measure the multi-scale composition, structure and mechanical function of mouse supraspinatus tendons from wild type, collagen V heterozygous and collagen V null mice. Overall, we found that the experimental groups were mechanically inferior to the wild type group, with larger
These triple-stranded, rope-like pro-collagen molecules must be processed by enzymes outside the cell. Once these molecules are processed, they arrange themselves into long, thin fibrils that cross-link to one another in the spaces around cells. The cross-links result in the formation of very strong, mature type V collagen fibers ...
php public static function sipRound(array $v) { # v0 += v1; list($v[0], $v[1]) = self::add( array($v[0], $v[1]), array($v[2], $v[3]) ); # v1=ROTL(v1,13); list($v[2], $v[3]) = self::rotl_64($v[2], $v[3], 13); # v1 ^= v0; $v[2] ^= $v[0]; $v[3] ^= $v[1]; # v0=ROTL(v0,32); list($v[0], $v[1]) = self::rotl_64((int) $v[0], (int) $v[1], 32); # v2 += v3; list($v[4], $v[5]) = self::add( array($v[4], $v[5]), array($v[6], $v[7]) ); # v3=ROTL(v3,16); list($v[6], $v[7]) = self::rotl_64($v[6], $v[7], 16); # v3 ^= v2; $v[6] ^= $v[4]; $v[7] ^= $v[5]; # v0 += v3; list($v[0], $v[1]) = self::add( array((int) $v[0], (int) $v[1]), array((int) $v[6], (int) $v[7]) ); # v3=ROTL(v3,21); list($v[6], $v[7]) = self::rotl_64((int) $v[6], (int) $v[7], 21); # v3 ^= v0; $v[6] ^= $v[0]; $v[7] ^= $v[1]; # v2 += v1; list($v[4], $v[5]) = self::add( array((int) $v[4], (int) $v[5]), array((int) $v[2], (int) $v[3]) ); # v1=ROTL(v1,17); list($v[2], $v[3]) = self::rotl_64((int) $v[2], (int) $v[3], 17); # v1 ^= v2;; $v[2] ^= $v[4]; $v[3] ...
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Mi 12-14 in V2-213; Fr 12-14 in U2-113; Do 10-12, einmalig in V3-201; Do 12-14, einmalig in T2-228; Do 10-12, einmalig in V3-201; Do 12-14, einmalig in T2-228; Do 12-14, einmalig in T2-228; Do 12-14, einmalig in T2-228; Do 10-12, einmalig in V2-105/115; Do 12-14, einmalig in T2-228; Do 12-14, einmalig in T2-228 ...
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44339119 -OEChem-10101305022D 37 39 0 0 0 0 0 0 0999 V2000 8.0785 2.9476 0.0000 Cl 0 0 0 0 0 0 0 0 0 0 0 0 8.9962 0.3922 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.0785 -1.1215 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 8.9271 -2.6315 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 9.8105 -1.1416 0.0000 N 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 0.4131 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 0.4131 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 7.1962 1.4130 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -0.0869 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3301 -0.0869 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 5.4641 1.4130 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 6.3301 1.9130 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0901 -0.1216 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7320 0.4131 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 4.5981 -1.0870 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.0901 1.9477 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -1.0870 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 2.8660 -0.0869 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 3.7320 -1.5870 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 8.9962 1.4339 0.0000 C 0 0 0 0 0 0 0 0 0 0 0 0 ...
We included three studies that enrolled a total of 413 adult patients that compared tacrolimus with microemulsion or oral solution cyclosporin. All studies were found to be at high risk of bias. Tacrolimus seemed to be significantly superior to cyclosporin regarding the incidence of bronchiolitis obliterans syndrome (RR 0.46, 95% CI 0.29 to 0.74), lymphocytic bronchitis score (MD -0.60, 95% CI -1.04 to -0.16), treatment withdrawal (RR 0.27, 95% CI 0.16 to 0.46), and arterial hypertension (RR 0.67, 95% CI 0.50 to 0.89). However, the finding for arterial hypertension was not confirmed when analysed using a random-effects model (RR 0.54, 95% CI 0.17 to 1.73). Furthermore, trial sequential analysis found that none of the meta-analyses reached the required information sizes and cumulative Z-curves did not cross trial sequential monitoring boundaries. Diabetes mellitus occurred more frequently among people in the tacrolimus group compared with the cyclosporin group when the fixed-effect model was ...
Researchers at the San Francisco VA Medical Center (SFVAMC) and the Un...The researchers hope their results will lead to an earlier more sensi...The study is being published in the September 2005 issue of the Journa...In obliterative bronchitis scar tissue forms in breathing passages of... For lung transplant patients the biggest barrier to long-term surviv...,Researchers,identify,genes,associated,with,lung,transplant,rejection,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Collagen alpha-1(V) chain is a protein that in humans is encoded by the COL5A1 gene. This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II. Type-V collagen GRCh38: Ensembl release 89: ENSG00000130635 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000026837 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Greenspan DS, Byers MG, Eddy RL, Cheng W, Jani-Sait S, Shows TB (May 1992). Human collagen gene ...
Implementation of an evidence-based guideline for managing respiratory and hemodynamic status is feasible and safe and was associated with reduction in severity of primary graft dysfunction. Further studies are required to determine whether such a guideline would lead to a consistent reduction in severity of primary graft dysfunction at other institutions. Creation of a protocol for postoperative care provides a template for further studies of novel therapies or management strategies for primary graft dysfunction ...
What is ehlers-danlos syndrome eds? Learn about ehlers-danlos syndrome eds symptoms, ehlers-danlos syndrome eds causes, diagnosis, and more.
Principal Investigator:SEKINE Yasuo, Project Period (FY):2003 - 2005, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Thoracic surgery
The immunohistopathology of the intrinsic basement membrane-associated antigens were examined in diabetic nephropathy. In early and moderate stages of disease there was polyantigenic expansion of all the intrinsic components of mesangium, glomerular basement membrane (GBM), and tubular basement membrane (TBM) assessed by polyclonal antisera to collagen types IV and V, laminin, and by monoclonal antibodies to type IV collagen and fibronectin and to four other intrinsic components of normal renal extracellular matrices (MBM10, 11, 12, and 15). In the mesangium the first intrinsic antigens to increase were fibronectin and type V collagen. In late stages of disease, there was a diminution in the mesangium of all of these antigens with the exception of type V collagen, which persisted. Additionally, antigens appeared in the mesangium, recognized by MBM11 and MBM15, which are normally present in fetal but not adult mesangial regions. Similarly, in the GBM in late stages of disease, there was a ...
Acute lung injury within 72 hours of lung transplantation, termed Primary Graft Dysfunction (PGD), is a major cause of early post-transplant morbidity and morta...
Ehlers-Danlos syndrome: Ehlers-Danlos syndrome,, rare, heritable disorder characterized by great elasticity of the skin, skin fragility with a tendency to hemorrhage, poor scar formation, and
Im 16.Ive always been active in sports, etc,but was diagnosed with scoliosis at 12. Since scoliosis doesnt cause pain apparently, it took several doctors and a different hospital to discover the real cause- Ehlers-Danlos Syndrome, hypermobility type. It causes weakened joints, etc, and reasonably explains my pain.However, two or so weeks ago, the pain was so severe that i had to be hospitalized and given several narcotics to eliminate it. I didnt recover for two weeks.Does anyone else have this disease or know anything that can eliminate my near-constant back and knee pain? Im willing to try anything at this point. I feel like Im wayyyy too young to be in pain all the time.thanks so much!I wish I could tell you that you are too young for all the pain you have to endure! I was diagnosed with Ehlers-Danlos Syndrome when I was around 30. Before that most doctors said it was in my head.The best thing Ive found to relieve the pain is a jaccuzi. However they can be hard to come by, so there ...
Ehlers-Danlos syndrome (EDS) is a group of clinically and genetically heterogeneous heritable connective tissue disorders (Yeowell and Pinnell 1993) affecting the skin, ligaments, joints, blood...
Ehlers-Danlos syndrome is a group of inherited disorders that affect your connective tissues - primarily your skin, joints and blood vessel walls. Connective tissue is a complex mixture of proteins and other substances that provides strength and elasticity to the underlying structures in your body.
Ehlers-Danlos syndrome is a group of inherited disorders that affect the connective tissues of the skin, joints and walls of the blood vessels. It is characterized by flexible joints and fragile skin.
Ehlers-Danlos syndrome (EDS) is a group of inherited conditions. These conditions affect the connective tissues. This type of tissue is found all over the body. There are at least 6 different varieties of EDS. They are classified by the type of tissue most affected and how it is inherited.
Ehlers-Danlos syndrome, cardiac valvular form information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
Biologixs calling all zebras! At Biologix, we assist individuals with Ehlers-Danlos syndromes and hypermobile spectrum disorders (HSD) in find relief and comfort they seek. Contact Biologix to learn more about our 10-point treatment plan today!
This article focuses on a presentation by Dr. Rodney Graham about Ehlers-Danlos Syndrome, better known by the general public as joint-hypermobility. Dr. Graham is a rheumatologist from the U.K. who has devoted much of his career to this specific illness.
Learn more about Ehlers-Danlos Syndrome at Palms West Hospital DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
A woman with Ehlers-Danlos syndrome explains how she realized that its OK to not be independent in the way she thought she had to be.
Online Doctor Chat - Ehlers-danlos syndrome, Ask a Doctor about when and why Magnetic resonance imaging is advised, Online doctor patient chat conversation by Dr. Yogesh D
My teen daughter was at a friends walking and looking at her phone and ran into the wall fracturing her radius. Her wrist was in an odd position that she could not move out of when I picked her up. I ...
hey everyone, I am sure many of you can relate to what Im feeling but sometimes i just feel so alone. I feel like searching for answers to my pain is useless, and that at some point I should just giv...
The Driscoll Theory® Newly Revised · The Cause of POTS in Ehlers-Danlos Syndrome and How to Reverse the Process by Diana Driscoll (Author), Ananya De…
2416850 管の穴から天を覗く v5k 2418930 断じて行えば鬼神も之を避く v5k 2418010 焼け棒杭に火が付く v5k 2451240 想像が付く v5k 2068870 閑古鳥が鳴く v5k 2418940 男鰥に蛆が湧く v5k 2417090 群羊を駆って猛虎を攻む v5m 2419790 無理が通れば道理が引っ込む v5m 2417000 金が子を生む v5m 2417970 小の虫を殺して大の虫を生かす v5s 1213500 甘言は偶人を喜ばす v5s 2141210 網呑舟の魚を漏らす v5s 2108430 入るを量りて出ずるを為す v5s 2417990 小人閑居して不善を為す v5s 1470130 能ある鷹は爪を隠す v5s 2397070 噂をすれば影が射す v5s 2419300 入るを計りて出ずるを制す v5s 2418670 先んずれば人を制す v5s 2419160 桃李物言わざれども下自ら蹊を成す v5s 2417910 女の一念岩をも通す v5s 2417640 思う念力岩をも徹す v5s 2095220 群盲象を評す v5s 2417080 君子豹変す v5s 2420120 歴史は繰り返す v5s 2417790 車軸を流す ...
2416850 管の穴から天を覗く v5k 2418930 断じて行えば鬼神も之を避く v5k 2418010 焼け棒杭に火が付く v5k 2451240 想像が付く v5k 2068870 閑古鳥が鳴く v5k 2418940 男鰥に蛆が湧く v5k 2417090 群羊を駆って猛虎を攻む v5m 2419790 無理が通れば道理が引っ込む v5m 2417000 金が子を生む v5m 2417970 小の虫を殺して大の虫を生かす v5s 1213500 甘言は偶人を喜ばす v5s 2141210 網呑舟の魚を漏らす v5s 2108430 入るを量りて出ずるを為す v5s 2417990 小人閑居して不善を為す v5s 1470130 能ある鷹は爪を隠す v5s 2397070 噂をすれば影が射す v5s 2419300 入るを計りて出ずるを制す v5s 2418670 先んずれば人を制す v5s 2419160 桃李物言わざれども下自ら蹊を成す v5s 2417910 女の一念岩をも通す v5s 2417640 思う念力岩をも徹す v5s 2095220 群盲象を評す v5s 2417080 君子豹変す v5s 2420120 歴史は繰り返す v5s 2417790 車軸を流す ...
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Retrieved from "https://en.wikipedia.org/w/index.php?title=Collagen,_type_XX,_alpha_1&oldid=705418915" ...
Type III collagen. liver, bone marrow, and lymphatic organs USES[edit]. Connective tissue has a wide variety of functions that ... Type I collagen is present in many forms of connective tissue, and makes up about 25% of the total protein content of the ... Type I Collagen". Journal of Biological Chemistry. 277 (6): 4223-31. doi:10.1074/jbc.M110709200. PMID 11704682.. ... Types of fibers: Tissue. Purpose. Components. Location Collagenous fibers. Bind bones and other tissues to each other. Alpha ...
COL1A1: collagen, type I, alpha 1 (17q21.33). *LUC7L3: LUC7 like 3 pre-mRNA splicing factor (17q21.33) ... This type of ideogram is generally used in genome browsers (e.g. Ensembl, UCSC Genome Browser). ... This type of ideogram represents actual relative band length observed under a microscope at the different moments during the ...
COL17A1 is collagen. Specifically type XVII, alpha 1. This may play a role in overall protein structure. PRDM16 binds to DNA ... This type of conclusion will require further information. Not enough consensus exists as to where in the body SMIM23 is ... The closest relatives to humans with the SMIM23 gene were in primates so two types of monkeys were picked which diverged around ... The same kind of investigation of protein localization in other types of species returned conflicting results. Many programs ...
The menisci contain 70% type I collagen.[6] The larger semilunar medial meniscus is attached more firmly than the loosely fixed ... In 1978, Shrive et al. reported that the collagen fibers of the menisci are oriented in a circumferential pattern.[6] When a ... This type of rehabilitation focuses on maintenance of full range of motion and functional progression without aggravating the ... Torg J, Quesdenfeld T (1971). "Effect of shoe type and cleat length on incidence and severity of knee injuries among high ...
Alpha 1 subunit of type VI collagen is the encoded protein. In terms of the diagnosis of Ullrich congenital muscular dystrophy ... It is associated with variants of type VI collagen, it is commonly associated with muscle weakness and respiratory problems, ... Bushby KM, Collins J, Hicks D (2014) Collagen type VI myopathies. Adv Exp Med Biol 802:185-199 "Congenital Muscular Dystrophy ... via ScienceDirect (Subscription may be required or content may be available in libraries.) "COL6A1 collagen type VI alpha 1 [ ...
This type of drag is also directly proportional to the laminar flow. When the laminar flow increases around the fish the ... Collagen fibrils begin to organize themselves in the dermal layer, which leads to the initiation of mineralization. The ... This same type of experiment was performed by another research group which implemented more variation in their biomimetic ... The patches of the matrix of the scale that are not ossified are composed of compacted collagen that allow it to maintain the ...
2007, (Type species of the genus).;: Greek noun amulon, starch; New Latin adjective lyticus -a -um (from Greek adjective ... 2007, ; New Latin noun collagenum, collagen; Latin adjective marinus -a -um, of the sea, marine; New Latin feminine gender ... the source of the type strain), Kenya.) Bacterial taxonomy Microbiology Classification of Genera AC entry in LPSN; Euzéby, J.P ...
The COL11A2 gene is responsible for providing instructions on making one component of the type XI collagen. Type XI collagen is ... which codes for the α2 strand of collagen type XI. It is a collagenopathy, types II and XI disorder. It causes facial ... The mutation of COL11A2 in Weissenbacher-Zweymüller syndrome disrupts the assembly of the type XI collagen molecules. The ... Collagen is found in bone. It is also found in cartilage that makes up most of the skeleton during early development. ...
Diagnostic tests include collagen gene-variant testing, collagen typing via skin biopsy, echocardiogram, and lysyl hydroxylase ... type 5 130080: type 8 - unspecified gene, locus 12p13 225310: type 10 - unspecified gene, locus 2q34 608763: Beasley-Cohen type ... It has two types. Type 1 occurs due to variations in the ZNF469 gene. Type 2 is due to variations in the PRDM5 gene. Classical- ... The first type is the nociceptive type, which is caused by injury sustained to tissues. The second type is neuropathic pain, ...
Abnormally shaped ends of one or more bones at a joint A Type 1 collagen or other connective tissue defect (as found in Ehlers- ... known also by EDS type III or Ehlers-Danlos syndrome hypermobility type (EDS-HT)). Ehlers-Danlos syndrome is a genetic disorder ... hypermobility syndrome was sometimes considered identical to Ehlers-Danlos syndrome hypermobile type/EDS Type 3. As no genetic ... For example: Typing can reduce pain from writing. Voice control software or a more ergonomic keyboard can reduce pain from ...
Found to have type I, III, VI, and XII collagen. See also[edit]. *Connective tissue in skeletal muscle ... The overall comprehensive organization of the perimysium collagen network, as well as its continuity and disparateness, however ...
... and type III collagen is largely replaced by type I. Collagen which was originally disorganized is cross-linked and aligned ... They begin to produce the much stronger type I collagen. Some of the fibroblasts mature into myofibroblasts which contain the ... Fibroblasts quickly produce abundant type III collagen, which fills the defect left by an open wound. Granulation tissue moves ... In order for an injury to be healed by regeneration, the cell type that was destroyed must be able to replicate. Cells also ...
Type II Collagen is an example of homo-trimeric protein. Porins usually arrange themselves in membranes as trimers. ...
Collagen, type XXIV, alpha 1 is a protein that in humans is encoded by the COL24A1 gene. Model organisms have been used in the ... "Entrez Gene: Collagen, type XXIV, alpha 1". Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput ...
2002: Discovery of Type 21 Human Collagen. 2002: Introduction of cGMP Chinese Herbal Medicinal Plant. 2004: Establishment of ...
There are multiple types of collagen: Type I (comprising skin, tendons and ligaments, vasculature and organs, as well as teeth ... Several types of protein based, nanosized fibers are being used in nanocomposites. These include collagen, cellulose, chitin ... "Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases." Gene vol. 707 (2019): ... Collagen has a hierarchical structure, forming triple helices, fibrils, and fibers. Collagen are a family of protein that ...
Among the many types of collagens, only the fibrillar and the basement membrane (type IV) collagens have been found in the ... Type II and type XI collagens compose the fibrils present in cartilage. These can be distinguished from collagens located in ... Different types of collagen have been found in all multicellular organisms, including sponges. It has been found that sponges ... It has also been found that 29 types of collagen have been found to exist in humans. This vast group can further be divided ...
Bornstein P, Kyriakides TR, Yang Z, Armstrong LC, Birk DE (Dec 2000). "Thrombospondin 2 modulates collagen fibrillogenesis and ... "Entrez Gene: THBS2 thrombospondin 2". Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix ... Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of ... "Mice that lack thrombospondin 2 display connective tissue abnormalities that are associated with disordered collagen ...
Type VIII, X) Basement membrane (Type IV) Other (Type VI, VII, XIII) Elastins, in contrast to collagens, give elasticity to ... Each type of connective tissue in animals has a type of ECM: collagen fibers and bone mineral comprise the ECM of bone tissue; ... The collagen can be divided into several families according to the types of structure they form: Fibrillar (Type I, II, III, V ... Laminins bind other ECM components such as collagens and nidogens. There are many cell types that contribute to the development ...
These mice have greater susceptibility to an asthma-like phenotype than wild-type animals. They are resistant to collagen- ... Two years is a common life expectancy in wild-type house mice. FVB mice show above average activity and anxiety. Because of ...
The menisci contain 70% type I collagen. The larger semilunar medial meniscus is attached more firmly than the loosely fixed, ... reported that the collagen fibers of the menisci are oriented in a circumferential pattern. When a compressive force is applied ... This type of rehabilitation focuses on maintenance of full range of motion and functional progression without aggravating the ... Degenerative meniscal tears are thought to occur as part of the aging process when the collagen fibers within the meniscus ...
It has been reported that biglycan interacts more strongly with collagen type II than collagen type I. Biglycan has been ... Pogány G, Hernandez DJ, Vogel KG (August 1994). "The in vitro interaction of proteoglycans with type I collagen is modulated by ... "Binding of the proteoglycan decorin to collagen type VI". J. Biol. Chem. 267 (8): 5250-6. PMID 1544908. Bowe MA, Mendis DB, ... "Interaction of biglycan with type I collagen". J. Biol. Chem. 270 (6): 2776-83. doi:10.1074/jbc.270.6.2776. PMID 7852349. ...
COL7A1: Collagen, type VII, alpha 1 (epidermolysis bullosa, dystrophic, dominant and recessive) ... This type of ideogram is generally used in genome browsers (e.g. Ensembl, UCSC Genome Browser). ... FRA3A encoding protein Fragile site, aphidicolin type, common, fra(3)(p24.2). *FRMD4B encoding protein FERM domain containing ... ZBED2: encoding protein Zinc finger BED-type containing 2. *ZNF9: zinc finger protein 9 (a cellular retroviral nucleic acid ...
... "type IV" collagen, a form of collagen not found in other sponges - although the spongin fibers that reinforce the mesohyl of ... Collencytes are another type of collagen-producing cell. Rhabdiferous cells secrete polysaccharides that also form part of the ... Although about 90% of modern sponges are demosponges, fossilized remains of this type are less common than those of other types ... as most types of their cells can move within their bodies and a few can change from one type to another. Even if a few sponges ...
Ehlers-Danlos syndrome - defect in the synthesis of collagen (Type I or III) causes progressive deterioration of collagens, ... Psoriatic arthritis is also a collagen vascular disease. Peyronie's disease - involving the growth of abnormal collagen (Type I ... Diseases in which inflammation or weakness of collagen tends to occur are also referred to as collagen diseases. Collagen ... Stickler syndrome - affects collagen (primarily type II and XI), and may result in a distinctive facial appearance, eye ...
The camera-type eye of vertebrates and cephalopods must be completely opaque. Finally, some structures are visible for a reason ... The lens is made of the protein crystallin; the cornea is made of the protein collagen. Other structures cannot be made ...
Such as type 4 collagen Shaw, Andrey S.; Filbert, Erin L. (January 2009). "Scaffold proteins and immune-cell signalling". ... "Human Homologue of the Drosophila Discs Large Tumor Suppressor Binds to p56 lck Tyrosine Kinase and Shaker Type Kv1.3 Potassium ...
This condition is caused by a mutation of COL7A1, the gene that codes for a type of collagen 7. Epidermis (skin) Dermis Lamina ... Anchoring fibrils (composed largely of type VII collagen) extend from the basal lamina of epithelial cells and attach to the ... Keene, Douglas R.; Sakai, Lynn Y.; Lunstrum, Gregory P.; Morris, Nicholas P.; Burgeson, Robert E. (1987). "Type VII collagen ... Burgeson, Robert E. (1993). "Type VII Collagen, Anchoring Fibrils, and Epidermolysis Bullosa". Journal of Investigative ...
Type I collagen is present in many forms of connective tissue, and makes up about 25% of the total protein content of the ... Type I Collagen". Journal of Biological Chemistry. 277 (6): 4223-31. doi:10.1074/jbc.M110709200. PMID 11704682.. ... TypesEdit. Connective tissue can be broadly subdivided into connective tissue proper, and special connective tissue.[5][6] ... groups of adipose cells are kept together by collagen fibers and collagen sheets in order to keep fat tissue under compression ...
Several types of catenins work with N-cadherins to play an important role in learning and memory (For full article, see ... Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR (October 2011). "A role for collagen XXIII in cancer cell ... For instance, higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened ... levels of collagen helped facilitate adhesions and anchorage-independent cell growth and provided evidence of collagen XXIII's ...
Atrophic acne scars have lost collagen from the healing response and are the most common type of acne scar (account for ... microspheres with collagen; human and bovine collagen derivatives, and fat harvested from the person's own body (autologous fat ... Many over-the-counter treatments in many forms are available, which are often known as cosmeceuticals.[168] Certain types of ... Ablative lasers (such as CO2 and fractional types) have also been used to treat active acne and its scars. When ablative lasers ...
collagen-containing extracellular matrix. Biological process. • positive regulation of inflammatory response. • positive ... positive regulation of type IV hypersensitivity. • positive regulation of transcription, DNA-templated. • humoral immune ...
List of human cell types derived from the germ layers. References[edit]. *^ .mw-parser-output cite.citation{font-style:inherit ... COL2A1 collagen disease. *Achondrogenesis *type 2. *Hypochondrogenesis. SLC26A2 sulfation defect. *Achondrogenesis *type 1B ...
The dissolution of collagen depends on time, temperature and environmental pH.[8] At high temperatures, the rate of collagen ... The study of diagenesis in rocks is used to understand the geologic history they have undergone and the nature and type of ... The composite nature of bone, comprising one-third organic (mainly protein collagen) and two thirds mineral (calcium phosphate ... The hydrolytic activity plays a key role in the mineral phase transformations that exposes the collagen to accelerated chemical ...
Diagnostic plates: intended to determine the type of color vision defect (protanopia or deuteranopia) and the severity of it. ... Corneal collagen cross-linking. Iris, ciliary body,. sclera, and anterior chamber. *Glaucoma surgery: Trabeculectomy ...
10% of all dislocations are anterior and this is broken down into superior and inferior types.[32] Superior dislocations ... syndrome is genetically inherited disorder that is thought to affect the encoding of the connective tissue protein's collagen ... the most common type of shoulder dislocation (96-98% of the time) occurs when the arm is in external rotation and abduction ( ...
Both types of plants occur in tropical areas, but only C3 plants occur naturally in colder areas. 12C and 13C occur in a ratio ... Nitrogen isotopes in bone collagen are ultimately derived from dietary protein, while carbon can be contributed by protein, ... This references the variety of types of labor (e.g., domestic vs. carrying heavy loads) labor that enslaved individuals were ... Many methods tracking these types of changes have been developed using a variety of skeletal series. For instance, in children ...
Possibly important to basement membrane architecture and tissue development, as a needed catalyst to make collagen IV.[37] ... "Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture". Cell. 157 ...
Data also proposed a decrease in weight gain as a result of increased consumption lessens the risk of developing diabetes type ... Foundation for strong healthy bones and teeth - majority of the calcium consumed as a child is deposited onto collagen bone ... Vitamin A ensures sufficient collagen is produced to build strong healthy bones and other connecting tissues (Deen & Hark, 2007 ... A 2007 study by Boeing et al., explored common chronic lifestyle diseases including diabetes type 2 mellitus, obesity, ...
Based on this, eight types of secondary structure are assigned. The 310 helix, α helix and π helix have symbols G, H and I and ... Two types of beta sheet structures exist; a beta bridge has symbol B while longer sets of hydrogen bonds and beta bulges have ... is at least 70°), and a blank (or space) is used if no other rule applies, referring to loops.[3] These eight types are usually ...
Type. Appearance (micrograph). Appearance (illustration). Approx. %. in adults. See also:. Blood values. Diameter (μm)[7]. Main ... It rises in response to allergies, parasitic infections, collagen diseases, and disease of the spleen and central nervous ... This type of white blood cell decreased is usually the neutrophil. In this case the decrease may be called neutropenia or ... Types of white blood cells can be classified in standard ways. Two pairs of broadest categories classify them either by ...
There are two types of alveolar epithelial cells - Type 1 pneumocytes represent 90% of the cell surface area, and are easily ... Mice that survive this initial onslaught go on to demonstrate an increase in lung collagen content, and decreased lung ... Type 2 pneumocytes are more resistant to damage, which is important as these cells produce surfactant, transport ions and ... Depending on the type and amount of irritant gas inhaled, victims can experience symptoms ranging from minor respiratory ...
... of which is collagen type 1 and the remaining 10% ground substance, which includes dentine-specific proteins), and 10% water ( ... TypesEdit. There are three types of dentin, primary, secondary and tertiary.[13][14] Secondary dentin is a layer of dentin ... It is of two types, either reactionary, where dentin is formed from a pre-existing odontoblast, or reparative, where newly ... It is unmineralized and consists of collagen, glycoproteins and proteoglycans. It is similar to osteoid in bone and is thickest ...
Types[edit]. General[edit]. Irwin Fridovich and Joe McCord at Duke University discovered the enzymatic activity of superoxide ... insights into heparin and collagen binding". J. Mol. Biol. 388 (2): 310-26. doi:10.1016/j.jmb.2009.03.026. PMID 19289127.. ... Fe and Mn types (which bind either iron or manganese), and the Ni type (which binds nickel). ... In wild-type S. cerevisiae, DNA damage rates increased 3-fold with age, but more than 5-fold in mutants deleted for either the ...
collagen trimer. • proteinaceous extracellular matrix. • extracellular region. • extracellular exosome. • extracellular space. ...
... organelles which are present in many cellular types throughout the human body. The cilia defects adversely affect "numerous ... is a rare genetic disorder of the skeletal dysplasia type. ... COL2A1 collagen disease. *Achondrogenesis *type 2. * ...
... as healthy collagen replaces the defective collagen with vitamin C repletion. Treatment can be orally or by intramuscular or ... Yamada H, Yamada K, Waki M, Umegaki K (October 2004). "Lymphocyte and plasma vitamin C levels in type 2 diabetic patients with ... including wound healing and collagen synthesis. In humans, vitamin C deficiency leads to impaired collagen synthesis, ... Hydroxylation allows the collagen molecule to assume its triple helix structure, and thus vitamin C is essential to the ...
Work at the Institute for Cell Biology, University of Bonn, showed that a certain type of autophagy, i.e., chaperone-assisted ... Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... CMA is significantly different from other types of autophagy because it translocates protein material in a one by one manner, ... the accumulation of damaged organelles in collagen VI deficient muscle fibres was prevented and cellular homeostasis was ...
Two types of PDGFRs have been identified: alpha-type and beta-type PDGFRs.[8] The alpha type binds to PDGF-AA, PDGF-BB and PDGF ... The addition of PDGF at specific time‐points has been shown to stabilise vasculature in collagen‐glycosaminoglycan scaffolds.[ ... Types and classification[edit]. There are five different isoforms of PDGF that activate cellular response through two different ... The receptor for PDGF, PDGFR is classified as a receptor tyrosine kinase (RTK), a type of cell surface receptor. ...
The three main types of hyaluronidases are two classes of eukaryotic endoglycosidase hydrolases and a prokaryotic lyase-type of ... "Testicular hyaluronidase induces tubular structures of endothelial cells grown in three-dimensional collagen gel through a CD44 ...
TNF can bind two receptors, TNFR1 (TNF receptor type 1; CD120a; p55/60) and TNFR2 (TNF receptor type 2; CD120b; p75/80). TNFR1 ... Tumor necrosis factor (TNF) alpha increases collagen accuulation and proliferation in intestinal myofibrobasts via TNF Receptor ... TNF is primarily produced as a 233-amino acid-long type II transmembrane protein arranged in stable homotrimers.[24][25] From ... TNF was thought to be produced primarily by macrophages,[36] but it is produced also by a broad variety of cell types including ...
Work at the Institute for Cell Biology, University of Bonn, showed that a certain type of autophagy, i.e., chaperone-assisted ... Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... There are three main types of autophagy (macroautophagy, microautophagy and Chaperone mediated autophagy), these are mediated ... CMA is significantly different from other types of autophagy because it translocates protein material in a one by one manner, ...
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C- ... Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen".[citation needed] Collagen IV ... type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 ... Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase?". Alcoholism: ...
... that is caused by a mutation in one of the three genes coding for type VI collagen.[2] These include COL6A1, COL6A2, and COL6A3 ... Okada M et al (2007) Primary collagen VI deficiency is the second most common congenital muscular dystrophy in Japan. Neurolog ... "Collagen VI related muscle disorders" (PDF). J. Med. Genet. 42 (9): 673-85. doi:10.1136/jmg.2002.002311. PMC 1736127 . PMID ...
Saad, Mohamed (Oct 1994). Low resolution structure and packing investigations of collagen crystalline domains in tendon using ... Kraft and sulfite (also called sulphite) refer to the type of pulping process used to remove the lignin bonding the original ... Instances are collagen[3] family of proteins, tendon, muscle proteins like actin, cell proteins like microtubules and many ...
After CGPD resolves, the skin may return to normal without scarring or may have small atrophic depressions with collagen loss, ... Gianotti-type perioral dermatitis or Facial Afro-Caribbean childhood eruption Specialty. Dermatology. ...
Possibly collagen and/or citrullinated self proteins. Chronic arthritis, inflammation, destruction of articular cartilage and ... Type V hypersensitivity. References[edit]. *^ a b c d e f g Kumar, Vinay; Abbas, Abul K.; Aster, Jon C. (2012-05-01). Robbins ... Type 4 hypersensitivity is often called delayed type hypersensitivity as the reaction takes several days to develop. Unlike the ... Diabetes mellitus type 1[1]. Pancreatic beta cell proteins (possibly insulin, glutamate decarboxylase). Insulitis, beta cell ...
Collagen cross-linking by applying riboflavin topically then shining UV light is a method to slow progression of corneal ... One such organism is Micrococcus luteus (American Type Culture Collection strain number ATCC 49442), which develops a yellow ... "Collagen cross-linking: when and how? A review of the state of the art of the technique and new perspectives". Eye and vision ...
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C- ... Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen".[citation needed] Collagen IV ... type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 ... Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase?". Alcoholism: ...
This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha ... Collagen, type VII, alpha 1 has been shown to interact with Laminin 5 and Fibronectin. Collagen GRCh38: Ensembl release 89: ... of type VII collagen is amino-terminal and chimeric. Homology to cartilage matrix protein, the type III domains of fibronectin ... "Cleavage of type VII collagen by interstitial collagenase and type IV collagenase (gelatinase) derived from human skin". The ...
Collagen type VI myopathies.. Bushby KM1, Collins J, Hicks D.. Author information. 1. Institute of Genetic Medicine, Newcastle ... Mutations in each of the three collagen VI genes COL6A1, COL6A2 and COL6A3 cause two main types of muscle disorders: Ullrich ... Publication type, MeSH terms, Substances, Supplementary concepts, Grant support. Publication type. *Review ... Collagen VI is an important component of the extracellular matrix which forms a microfibrillar network that is found in close ...
I report a series of studies targeted at elucidating mechanisms of proteostasis for collagen type-1, the most abundant collagen ... Misfolding collagen variants cause disease, including osteogenesis imperfecta in the case of collagen-I variants. The origins ... Despite decades of work, however, the mechanisms of collagen folding remain poorly understood, and collagen quality control is ... The folding, quality control, and secretion of collagen presents a significant challenge to collagen-producing cells. Each ...
About 47% of these are collagen, 18% are anti-aging, and 12% are animal extract. A wide variety of collagen type ii options are ... chicken collagen type ii amino collagen c collagen granule firm up collagen cartilage collagen us collagen softgel oem collagen ... Raw material hydrolyzed collagen type 2 cas 9064-67-9 fish collagen powder type II hydrolyzed collagen type II powder ... Tags: Undenatured Collagen Type Ii , Undenatured Collagen Type 2 , Collagen Type 2 Undenatured ...
The collagen IV molecule is 400 nm long and consists of two alpha 1 (IV) and one alpha 2 (IV) chains. Their genes COL4A1 and ... Basement membrane (type IV) collagen Matrix Biol. 1995 Feb;14(6):439-45. doi: 10.1016/0945-053x(95)90001-2. ... The collagen IV molecule is 400 nm long and consists of two alpha 1 (IV) and one alpha 2 (IV) chains. Their genes COL4A1 and ... Collagen IV is involved in interactions with cells and possesses two specific recognition sites for the integrins alpha 1 beta ...
Healthy Origins, Natural, UC-II with Undenatured Type II Collagen, 40 mg, 120 Veggie Caps. 6 ... Now Foods, UC-II Joint Health, Undenatured Type II Collagen, 120 Veg Capsules. 86 ... Healthy Origins, Natural, UC-II with Undenatured Type II Collagen, 40 mg, 60 Veggie Caps. 3 ... Life Extension, Bio-Collagen with Patented UC-II, 40 mg, 60 Small Caps. 20 ...
Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. Here the D is approximately 67 nm and ... These form the most abundant collagens in vertebrates. ... There are 29 genetically distinct collagens present in animal ... Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen ... These form the most abundant collagens in vertebrates.. Collagen types I - V. *Type I collagen is found throughout the body ...
Collagens constitute nearly 30% of all proteins in our body (1). Among the 29 collagen types, type IV collagen is a major and ... collagen types I, II, and III) and networks (collagen types IV and VI) (1). Proper posttranslational modifications of collagen ... C and D) Presence of type IV collagen in both P3H2-null and control embryos at E6 (green) is shown. colIV, type IV collagen. (E ... Type I collagen used for SPR experiments was extracted from mouse skin as previously described (6). Type IV collagen extracted ...
Danio rerio collagen, type I, alpha 2 (col1a2), mRNA Danio rerio collagen, type I, alpha 2 (col1a2), mRNA. gi,48762666,ref,NM_ ... Danio rerio collagen, type I, alpha 2 (col1a2), mRNA. NCBI Reference Sequence: NM_182968.2 ... LSBio COL1A2 / Collagen I Alpha 2 Proteins [LifeSpan BioSciences, Inc.] LSBio COL1A2 / Collagen I Alpha 2 Proteins. LifeSpan ... Assembly of collagen fibrils and other multimeric structures Assembly of collagen fibrils and other multimeric structures ...
... dginn at olivet.edu dginn at olivet.edu Sun Jun 9 23:37:26 EST 1996 *Previous message: ... Greetings, I am looking for a plasmid probe with a cDNA sequence for Rat Type I collagen gene [alpha1(I) and/or alpha2(I)]. ... Previous message: Rat Type I collagen cDNA probe needed *Next message: Rat Type I collagen cDNA probe needed ...
... mainly type II collagen), the outer elastin layer (OEL), and a layer of type I collagen fiber bundles (cI). In the col1a2−/− ... into the type I collagen triple helix. However, to obtain a full understanding of zebrafish type I collagen, the exact trimer ... Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies. Charlotte Gistelinck, Ronald Y. Kwon, ... Zebrafish type I collagen mutants faithfully recapitulate human type I collagenopathies. Charlotte Gistelinck, Ronald Y. Kwon, ...
The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance ... The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance ... This chapter outlines several methods to assess the in vitro production of type I collagen that are employed in our laboratory ... Type I collagen Western immunoblot real-time PCR nuclear run-on assay ...
b-2Cool®​ is a natural ingredient supplying native (undenatured) type II collagen, whose efficacy in joint health improvement ... Discover b-2Cool, Bioibericas native type II collagen. Published 07-Nov-2017. ... is able to modulate the immune response against endogenous type II collagen in the cartilage. ...
COL18A1, KNO, KNO1, KS, Collagen, type XVIII, alpha 1, collagen type XVIII alpha 1, collagen type XVIII alpha 1 chain. ... This gene encodes the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix ... 2002). "Epitope-defined monoclonal antibodies against multiplexin collagens demonstrate that type XV and XVIII collagens are ... "Cloning of cDNA and genomic DNA encoding human type XVIII collagen and localization of the alpha 1(XVIII) collagen gene to ...
Collagen Type 2, slows down. But thanks to science and our Collagen Joint Complex you can fight this common sign of aging. ... Using hydrolysis to convert large collagen molecules into small peptides, our Collagen Joint Complex can provide joint and ... The length of time for the expiration date or best used before date depends on the type of product, as well as the brand. ... It is important to note that certain types of products (e.g. glass containers, liquids, fragile, refrigerated or ice packed) ...
Compare collagen type XXIV alpha 1 Biomolecules from leading suppliers on Biocompare. View specifications, prices, citations, ... Your search returned 1 collagen type XXIV alpha 1 Biomolecules across 1 supplier. ... Strong, native & highly biocompatible - introducing next generation collagen fibers for the development of novel therapies in ...
Compare collagen type XXV alpha 1 Biomolecules from leading suppliers on Biocompare. View specifications, prices, citations, ... Transient overexpression lysate of collagen, type XXV, alpha 1 (COL25A1), transcript variant 1 ... Your search returned 5 collagen type XXV alpha 1 Biomolecules across 3 suppliers. ... Strong, native & highly biocompatible - introducing next generation collagen fibers for the development of novel therapies in ...
... when adherent to type V collagen. Yet, staurosporine induced Akt and Erk activation on H295R cells: the adhesion on type V ... Adrenocortical cancer Type V collagen Apoptosis Staurosporine This is a preview of subscription content, log in to check access ... Luparello C, David F, Campisi G, Sirchia R. T47-D cells and type V collagen: a model for the study of apoptotic gene expression ... Luparello C, Sirchia R, Longo A. Type V collagen and protein kinase Cη down-regulation in 8701-BC breast cancer cells. Mol ...
Type II Collagen 1240Cit 1237-1249. B [auth C]. 13. Homo sapiens. Mutation(s): 0 Gene Names: COL2A1. ... HLA-DRB1 in complex with Type II collagen peptide. *DOI: 10.2210/pdb6BIN/pdb ... Type: Remediation. Reason: Carbohydrate remediation Changes: Atomic model, Data collection, Derived calculations, Structure ...
II collagen and weakly reacts with bovine type-II collagen. Does not react with mouse collagen type I, rat type-I or type-III ... Collagen Type II Detection. Collagen Type II is a major constituent of hyaline and elastic cartilage protein. Collagen Type II ... Weakly reacts with bovine type-II collagen. Does not cross‑react with rat type‑I & type-III collagen or with mouse type-II ... The Rat Collagen Type 2 Monoclonal Antibody specifically recognizes rat type-II collagen. It is validated for immunoblotting ...
Discover the benefits of native type II collagen for convenient and low-dose supplements. ... Collagen is becoming increasingly popular in the joint health market. ... This is why hydrolysed collagen is also known as collagen peptides, or denatured type II collagen. Native type II collagen is ... Native type II collagen has been shown to help modulate the immune response against endogenous type II collagen through its ...
The purified mass is dried to provide the desired Type I collagen product which may be ground into a powder or formed into a ... The enzyme-treated comminuted material which is rich in collagen is dispersed in an organic acid to cause the fibrillar mass to ... source such as poultry feet that incorporates a fibrillar mass of connective tissue as well as bony tissue to yield a collagen ... collagen matrix or sponge, depending on the end use therefor. ... A process for extracting type I collagen from an avian ...
Type VII collagen induction did not generate anti-type VII collagen autoantibodies in patients blood or skin. CONCLUSION. ... Newly created type VII collagen varied from 20% to 165% of that expressed in normal human skin and persisted for 3 months. ... Primary outcomes were induction of type VII collagen and AFs at the test sites and safety assessment. A secondary outcome ... Gentamicin induces functional type VII collagen in recessive dystrophic epidermolysis bullosa patients. ...
... serum type IV collagen (ng/ml) versus urine albumin (A:C [μg/mg], r = −0.001) and (B) serum type IV collagen versus creatinine ... Serum Type IV Collagen in Diabetic Patients at Risk for Nephropathy. Margo P. Cohen, Clyde W. Shearman, Gregory T. Lautenslager ... Serum Type IV Collagen in Diabetic Patients at Risk for Nephropathy. Margo P. Cohen, Clyde W. Shearman, Gregory T. Lautenslager ... Serum Type IV Collagen in Diabetic Patients at Risk for Nephropathy Message Subject (Your Name) has forwarded a page to you ...
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.. ... We demonstrate the direct involvement of increased collagenase activity in the cleavage of type II collagen in osteoarthritic ... involved in the cleavage and denaturation of type II collagen in articular cartilage, that this is increased in OA, and that ... neoepitopes generated by cleavage of native human type II collagen by collagenase matrix metalloproteinase (MMP)-1 (collagenase ...
BioCell Collagen has clinically documented bioavailability, and has been shown to support joint health and skin hydration.* For ... Jarrow Formulas Type ll Collagen Complex providesBioCell Collagen, a low molecular weight, water-soluble glycosaminoglycan ... What Does Type II Collagen Complex Do? Jarrow Formulas® Type ll Collagen Complex provides BioCell Collagen®, a low molecular ... Made with BioCell Collagen®. BioCell Collagen® is a registered trademark of BioCell Technology, LLC, Newport Beach, CA and is ...
... the most abundant type of collagen in the human body, is a major structural protein in skin, bone, tendon, and fibrous ... Type 1 collagen,colagen,MegaCult collagen,CollagenCult collagen,MegaCult-C collagen,collagen gells,collagen 1,7001 ... Type I Collagen is the most abundant type of collagen in the human body and is a major structural protein prevalent in skin, ... The different types of collagen vary in the primary amino acid sequence of their polypeptide chains, with type I collagen being ...
Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen. Proc Natl Acad ... containing 10 mg bioactive undenatured type II collagen).. In addition to the bioactive UC·II undenatured type II collagen, ... Most of the type II chicken collagen found in dietary supplements is denatured or hydrolized, which means that high heat and/or ... Undenatured type II collagen is made using little or no heat and very limited processing - just enough to concentrate the ...
1CTP stands for Carboxy-Terminal Telopeptide of Type 1 Collagen. 1CTP is defined as Carboxy-Terminal Telopeptide of Type 1 ... How is Carboxy-Terminal Telopeptide of Type 1 Collagen abbreviated? ... Terminal-Telopeptide-of-Type-1-Collagen-(1CTP).html,1CTP,/a,. ... 1CTP stands for Carboxy-Terminal Telopeptide of Type 1 Collagen ... S.v. "1CTP." Retrieved September 20 2018 from https://www.acronymfinder.com/Carboxy_Terminal-Telopeptide-of-Type-1-Collagen-( ...
  • Using hydrolysis to convert large collagen molecules into small peptides, our Collagen Joint Complex can provide joint and cartilage support. (iherb.com)
  • Hydrolysed collagen is manufactured via a specific hydrolysis process, where enzymes "cut" the triple helix molecule into smaller pieces, i.e. short-chain peptides. (nutraingredients.com)
  • This is why hydrolysed collagen is also known as collagen peptides, or denatured type II collagen. (nutraingredients.com)
  • Bluebonnet's Beautiful Ally™ Collagen Powder is specially formulated with collagen peptides types I + III, key structural components for lustrous hair, firm skin and durable nails. (vitacost.com)
  • Collagen peptides help to replenish the nutrients lost over time, boosting collagen production while reducing its breakdown thereby enhancing the skin's hydration and natural elasticity while counteracting visible signs of aging. (vitacost.com)
  • Super Collagen™ is made up of the collagen peptides Type 1 & 3 which support collagen in skin, hair, nails, muscles, tendons, ligaments and bones. (vitaminworld.com)
  • Two peptides, CB8 and CB11, are sites of platelet binding and activation on collagen-type II. (sigmaaldrich.com)
  • Bluebonnet's Beautiful Ally™ Collagen 1000 mg Caplets are specially formulated with collagen peptides types I + III and identity-preserved (IP) vitamin C‚ key structural components for firm skin‚ lustrous hair and durable nails. (pureformulas.com)
  • I'm not new to collagen peptides. (amzn.com)
  • I've been using them for a couple months now with surprising results and I'm a firm believer that collagen peptides have helped my skin look and feel tighter as well as more hydrated. (amzn.com)
  • CellAdhere™ Type I Collagen, Bovine, Solution is prepared from collagen extracted from bovine hide and contains a high monomer content. (stemcell.com)
  • Other Ingredients: Super Collagen™ Type 1&3 derived from pharmaceutical food grade bovine collagen. (vitaminworld.com)
  • Collagen from bovine tracheal cartilage has been used to induce arthritis in male DBA/1 mice. (sigmaaldrich.com)
  • Bovine COLLAGEN Type V has been prepared from Bovine Placenta and is chromatographically and immunologically pure. (rockland-inc.com)
  • Collagen supplements are derived from either fish, bovine, or porcine sources. (allstarhealth.com)
  • When choosing a collagen-be it grass-fed bovine or marine -you should look for what types of collagen it contains to see if it matches up with your needs. (mindbodygreen.com)
  • You can find it in both marine and bovine collagen supplements. (mindbodygreen.com)
  • This type of collagen is found in marine collagen but not grass-fed bovine. (mindbodygreen.com)
  • CIA is induced in genetically susceptible strains of mice by immunization with type II bovine collagen (CII). (hindawi.com)
  • Collagen type IV purified from Human and Bovine placenta. (acris-antibodies.com)
  • Collagens were extensively purified for immunization from human and bovine placenta and cartilage by limited pepsin digestion and selective salt precipitation. (acris-antibodies.com)
  • Collagen alpha-1(VII) chain is a protein that in humans is encoded by the COL7A1 gene. (wikipedia.org)
  • This gene encodes the alpha chain of type VII collagen. (wikipedia.org)
  • Greetings, I am looking for a plasmid probe with a cDNA sequence for Rat Type I collagen gene [alpha1(I) and/or alpha2(I)]. Does anyone know where I could get ahold of this probe - either a company or a laboratory? (bio.net)
  • This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. (nih.gov)
  • Association of reduced type IX collagen gene expression in human osteoarthritic chondrocytes with epigenetic silencing by DNA hypermethylation. (nih.gov)
  • Collagen alpha-1(XVIII) chain is a protein that in humans is encoded by the COL18A1 gene . (wikipedia.org)
  • Recessive dystrophic epidermolysis bullosa (RDEB) is an incurable disease caused by mutations in the gene encoding type VII collagen, the major component of anchoring fibrils (AF). (jci.org)
  • p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene. (uniprot.org)
  • Collagen α-1 (XXIII) chain is a protein encoded by COL23A1 gene , which is located on chromosome 5q35 in humans, and on chromosome 11B1+2 in mice. (wikidoc.org)
  • A comparison with the distribution of gelatinase B mRNA in follicles that had just ovulated indicated that the collagen type-I α1 gene is expressed in the theca cells. (bioone.org)
  • Transcriptional regulation of the human type X collagen gene expression. (diva-portal.org)
  • Laboratory tested to naturally contain collagen type II protein, and hyaluronic acid, glucosamine, and chondroitin, Therefore, naturally provides all necessary components for maintaining health joints. (nutritiongeeks.com)
  • It contains 65-70% Collagen Type II and naturally contains 30-35% carbohydrates (chondroitin, glucosamine & hyaluronic acid), the major components of joint cartilage. (nutritiongeeks.com)
  • The mucopolysaccharides consists of Glucosamine, Chondroitin, and Hyaluronic Acid, the makeup of synovial fluid and sugar aminos required to make collagen type II cells. (nutritiongeeks.com)
  • NeoCell Collagen 2 contains glucosamine, chondroitin and hyaluronic acid. (puritan.com)
  • Every scoop features hydrolyzed Collagen types I, II, III, V, and X from quality food sources + Hyaluronic Acid & Vitamin C. (romanceuniversity.org)
  • Discover the benefits of native type II collagen for convenient and low-dose supplements. (nutraingredients.com)
  • Native type II collagen vs. hydrolysed type II collagen: what's the difference? (nutraingredients.com)
  • Native type II collagen is not hydrolysed and maintains its characteristic three-dimensional structure. (nutraingredients.com)
  • Through this mode of action native type II collagen is recognised by the immune system as an endogenous substance, i.e. naturally occurring in the body, and deactivates the body's immune response against its own collagen. (nutraingredients.com)
  • Oral administration of native type II collagen induces oral tolerance to pathological immune responses and may be useful in arthritis. (wikipedia.org)
  • We have found that intradermal injection of native type II collagen extracted from human, chick or rat cartilage induces an inflammatory arthritis in approximately 40% of rats of several strains whether complete Freund's adjuvant or incomplete Freund's adjuvant is used. (rupress.org)
  • Berg Nutrition is bringing a new native type II collagen option to the U.S. market with branded b-2Cool, manufactured by the Barcelona-based Bioiberica. (nutritionaloutlook.com)
  • Having another source allows brands into the market that have so far shied away from using native type II collagen in their formulas," said Cai Berg, owner and president of Berg Nutrition, to Nutritional Outlook. (nutritionaloutlook.com)
  • The native type II collagen, sourced from chicken sternum, works with the body's immune system to turn off T-cell attacks to endogenous type II collagen in the body, reducing the destruction of collagen. (nutritionaloutlook.com)
  • Native type II collagen, which is extracted to maintain a very high molecular weight, is not meant to be absorbed by the body. (nutritionaloutlook.com)
  • The collagen IV molecule is 400 nm long and consists of two alpha 1 (IV) and one alpha 2 (IV) chains. (nih.gov)
  • Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. (nih.gov)
  • Native type II co-lagen modified by limited pepsin digestion still produces arthritis, suggesting that type-specific determinants residing in the helical region of the molecule are responsible for the induction of disease. (rupress.org)
  • The molecule of collagen XXIII can be found either in membrane-bond form or in shed form. (wikidoc.org)
  • Collagen XXIII molecule might be shed at Golgi apparatus or the cellular membrane . (wikidoc.org)
  • A common feature of transmembrane collagens is the presence of two forms of the molecule: a full-length membrane-bound form and an ectodomain shed form . (wikidoc.org)
  • This molecule is also known as the collagen IV noncollagenous1 (NC1) domain. (sciencephoto.com)
  • The cellular effects of type IV collagen were studied in pancreatic cancer cell lines by reducing type IV collagen expression through RNA interference and by functional receptor blocking of integrins and their binding-sites on the type IV collagen molecule. (diva-portal.org)
  • Collagens for antiaging and beauty are typically hydrolyzed collagens, meaning that the collagen molecule is cut up into very small pieces, thus the lower molecular weight," said Berg. (nutritionaloutlook.com)
  • Here, we uncover the structural basis for both chain selection and stagger formation of a collagen molecule. (rcsb.org)
  • Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. (jci.org)
  • These data suggest that collagenase(s) produced by chondrocytes is (are) involved in the cleavage and denaturation of type II collagen in articular cartilage, that this is increased in OA, and that MMP-13 may play a significant role in this process. (jci.org)
  • Type II collagen is the basis for articular cartilage and hyaline cartilage, formed by homotrimers of collagen, type II, alpha 1 chains. (wikipedia.org)
  • It makes up 50% of all protein in cartilage and 85-90% of collagen of articular cartilage. (wikipedia.org)
  • Low-intensity pulsed ultrasound (LIPUS) increases the articular cartilage type II collagen in a rat osteoarthritis model. (thefreedictionary.com)
  • MMP-13 is by far the most studied of the matrix metalloproteinases in terms of its role in cartilage, as it is considered the major catabolic effector in osteoarthritis and other forms of arthritis, owing to its robust ability to cleave the type II collagen that predominates in articular cartilage. (thefreedictionary.com)
  • Super Collagen™ is enzymatically hydrolyzed, providing an amino acid ratio with a low molecular weight for maximum bioavailability and utilization by the body. (vitaminworld.com)
  • When Super Collagen™ is taken internally, the body receives the raw materials it needs to supplement the collagen found in all of these areas and may act as a messenger to trigger the synthesis of new collagen fibers. (vitaminworld.com)
  • Super Collagen™ is neutral in taste and is specifically formulated in an easy to take powder form. (vitaminworld.com)
  • Directions: As a daily dietary supplement, dissolve one scoop of Super Collagen™ Dietary Supplement with one spoon of water or orange juice. (vitaminworld.com)
  • So did I see any significant improvements with this NeoCell Super Collagen+C Type 1 & 3 supplement? (vivawoman.net)
  • So when I spotted that Neocell had collagen capsules in these NeoCell Super Collagen+C Type 1 & 3, I decided to get a bottle to try. (vivawoman.net)
  • As we age, our body's ability to produce the key structural protein in cartilage tissue, Collagen Type 2, slows down. (iherb.com)
  • [1] ​ ​ Of the 28 different types of collagen that have been identified, type II collagen is the main structural protein in cartilage. (nutraingredients.com)
  • The primary protein in cartilage, Type II Collagen (CII) is crucial to joint health and function. (brightsurf.com)
  • Collagen 2 is the key structural protein in cartilage tissue. (puritan.com)
  • Type II Collagen is the principal structural protein in cartilage. (totaldiscountvitamins.com)
  • Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. (news-medical.net)
  • Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen respectively. (news-medical.net)
  • Type II collagen does form fibrils. (wikipedia.org)
  • Two pro a1 (I) chain associate in trimers with one pro a2 (I) chain to form the type I collagen fibrils after proteolysis. (atlasgeneticsoncology.org)
  • METHODS: We studied how two structurally distinct forms of type I collagen, monomer versus polymerized fibrils, affect cell proliferation, mitogen-activated protein kinase (MAPK) activation, and expression of G1-phase regulatory proteins in cultured rat mesangial cells (MCs). (biomedsearch.com)
  • The excess accumulation of type I collagen within tissues leads to organ dysfunction and occurs as a result of an imbalance between synthesis and degradation. (springer.com)
  • Angiotensin II (Ang II)-mediated stimulation of fibroblast growth and collagen type I synthesis is believed to be an important component of the cardiac remodeling process in hypertension and chronic ischemia. (ahajournals.org)
  • Thus, pioglitazone attenuates Ang II-mediated collagen type I synthesis in cardiac fibroblasts. (ahajournals.org)
  • The expression of procollagen 1 C-terminal peptide (PICP) and collagen type 1 C-terminal telopeptide (ICTP), two major by-products in the synthesis and degradation of collagen, was shown to be positively correlated with inflammatory mediator levels in previous studies. (dovepress.com)
  • The increased levels of serum PICP in COPD might indicate the condition of airway remodeling, and IL-6 and/or IL-8 might play an important role in stimulating collagen synthesis. (dovepress.com)
  • Vitamin C is added to the formula, as it is an essential nutrient required for collagen synthesis by the body. (netrition.com)
  • In an attempt to elucidate the role played by neoplastic epithelial cells in the formation of stromal collagen, the synthesis of collagen by two cloned human gastric carcinoma cell lines was studied. (aacrjournals.org)
  • The relative activity of collagen synthesis determined by using purified collagenase was slightly higher than that of fibroblasts derived from human synovial membrane in culture. (aacrjournals.org)
  • RESULTS: Polymerized type I collagen completely prevented the increase of DNA synthesis and cell replication induced by 5% fetal calf serum (FCS) or 25 ng/mL platelet-derived growth factor (PDGF) in MCs on monomer type I collagen. (biomedsearch.com)
  • Fitzgerald, J., Lamande, S. R., and Bateman, J. F. (1999) Proteasomal degradation of unassembled mutant type I collagen pro-alpha1(I) chains. (springer.com)
  • Type I or III collagen extracted from skin, cartilage proteoglycans and alpha1(II) chains were incapable of eliciting arthritis, as was type II collagen injected without adjuvant. (rupress.org)
  • COL1A2 encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. (antibodies-online.com)
  • In MCs plated on monomer type I collagen, alpha1, alpha2, and beta1 integrin chains were recruited into focal contacts. (biomedsearch.com)
  • However, on polymerized type I collagen, alpha2 and beta1, but not alpha1, integrin chains were condensed into focal contacts. (biomedsearch.com)
  • Collagens constitute nearly 30% of all proteins in our body. (pnas.org)
  • Berg, R. A., Schwartz, M. L., and Crystal, R. G. (1980) Regulation of the production of secretory proteins: intracellular degradation of newly synthesized "defective" collagen. (springer.com)
  • This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. (wikipedia.org)
  • 2,3 Collagens are proteins that consist of a triple helix of polypeptide chains and globular domains, and comprise a family of proteins of at least 19 genetically distinct types, among which type I and type III constitute two-thirds. (ahajournals.org)
  • The functions of collagen XXIII are still unknown, although it is believed that they could be similar to other transmembrane proteins, such as collagen XIII . (wikidoc.org)
  • Apart from having the characteristic structure of transmembranous collagens, all three proteins present a high level of amino acid residue conservation in collagenous and non-collagenous domains. (wikidoc.org)
  • The deduced amino acid sequence of the collagen type-I α1 chain was homologous to those of the proteins from other vertebrate species. (bioone.org)
  • This product is free from other collagens, human serum proteins and non-collagen extracellular matrix proteins. (rockland-inc.com)
  • Collagen refers to a group of structural proteins found throughout the body, but primarily in the connective tissue such as skin, bone, cartilage, tendons and ligaments. (allstarhealth.com)
  • Additionally we are shipping Collagen, Type I, alpha 2 Antibodies (119) and Collagen, Type I, alpha 2 Proteins (10) and many more products for this protein. (antibodies-online.com)
  • PDAC tumours are characterised by a voluminous stroma that is rich in extracellular matrix (ECM) molecules such as collagens, hyaluronan (HA) and matricellular proteins. (diva-portal.org)
  • This is potentially reflective of the specific nature of the trabecular meshwork environment, which facilitates aqueous outflow from the eye, and we speculate that extracellular matrix ions and proteins might prevent a more tight packing of type VI collagen tetramers that form the assemblies. (molvis.org)
  • Distinct structural forms of type I collagen modulate cell cycle regulatory proteins in mesangial cells. (biomedsearch.com)
  • This product has been prepared by Immunoaffinity Chromatography using immobilized antigens followed by extensive cross-adsorption against other collagens, human serum proteins and non-collagen extracellular matrix proteins to remove any unwanted specificities. (acris-antibodies.com)
  • Contains Type 1, 2, and 3: There are 3 essential proteins that are required to keep your body in tiptop shape. (romanceuniversity.org)
  • Frozen MC4R-KO mouse liver section was stained with Goat Anti-Type I Collagen-UNLB (SB Cat. (southernbiotech.com)
  • Paraffin embedded rat kidney section post uninephrectomy was stained with Goat Anti-Type I Collagen-UNLB (SB Cat. (southernbiotech.com)
  • Human fibroblasts were stained with Goat Anti-Type I Collagen-UNLB (SB Cat. (southernbiotech.com)
  • No. 1200-01S) was resolved by electrophoresis, transferred to PVDF membrane, probed with Goat Anti-Type I Collagen-UNLB (SB Cat. (southernbiotech.com)
  • Collagen was detected with serially diluted Goat Anti-Type I Collagen-UNLB (SB Cat. (southernbiotech.com)
  • Type VII collagen induction did not generate anti-type VII collagen autoantibodies in patients' blood or skin. (jci.org)
  • The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. (wikipedia.org)
  • Collagen chains undergo several posttranslational modifications that are indispensable for proper collagen function. (pnas.org)
  • In its natural form, collagen has a folded triple helix structure consisting of long polypeptide chains (see figure 1). (nutraingredients.com)
  • All collagens are characterized by a secondary protein structure consisting of three polypeptide chains wrapped around one another in a triple helical arrangement. (stemcell.com)
  • The different types of collagen vary in the primary amino acid sequence of their polypeptide chains, with type I collagen being comprised of two identical α1(I) chains and one α2(I) chain that spontaneously form the triple helix in solution. (stemcell.com)
  • The a1 (I) chains of the type I collagen are synthesised as procollagen molecules containing amino and carboxy-terminal propeptides, wich are removed by site-specific endopeptidase. (atlasgeneticsoncology.org)
  • To analyze the possible involvement of collagen-binding integrins in type I collagen-derived growth signals further, distribution patterns of integrin chains were examined by immunocytochemistry. (biomedsearch.com)
  • There are homo- and hetero-trimeric types of collagen consisting of one, two or three distinct chains. (rcsb.org)
  • Three distinct chains (α1, α2 and α3) of the non-collagenous domain 2 (NC2) of type IX collagen are assembled to guide triple-helical sequences in the leading, middle and trailing positions. (rcsb.org)
  • Collagen VI is also found in the interstitial space of many tissues including muscle, tendon, skin, cartilage, and intervertebral discs. (nih.gov)
  • There are 29 genetically distinct collagens present in animal tissues. (news-medical.net)
  • Type I collagen is found throughout the body except in cartilaginous tissues. (news-medical.net)
  • Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. (nih.gov)
  • Collagen is the main component of connective tissues that make up tendons, ligaments, skin and cartilage. (nutraingredients.com)
  • Although it has many important functions in the body, collagen is best known for its structural role - providing a framework for tissues throughout the body. (nutraingredients.com)
  • Type I Collagen is the most abundant type of collagen in the human body and is a major structural protein prevalent in skin, bone, tendon, and other fibrous connective tissues. (stemcell.com)
  • Type XXIII collagen is expressed in both adult tissues and developing organs. (wikidoc.org)
  • Type IV collagen is a major macromolecular constituent of basement membranes and can be readily isolated from basement-membrane-rich tissues or highly vascularized tissues such as the placental villi. (rockland-inc.com)
  • In contrast, type VI collagen appears to be prevalent in several tissues even though it has been isolated largely from placental villi preparations. (rockland-inc.com)
  • Collagen type I is the fibrillar collagen found in most connective tissues, including cartilage. (rockland-inc.com)
  • Collagen type I is a protein that strengthens and supports many tissues in the body, including cartilage, bone, tendon, skin and the white part of the eye (sclera). (rockland-inc.com)
  • Branched {\em type I} collagen fiber networks provide extracellular support in mammalian tissues. (aps.org)
  • Type VI collagen is a primary component of the extracellular matrix of many connective tissues. (molvis.org)
  • Doctor's Best Collagen Types 1 & 3 contains pure collagen protein, providing the fundamental building blocks for growth and maintenance of healthy tissues. (netrition.com)
  • A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. (curehunter.com)
  • Type-II collagen (CII) is highly expressed in cartilage tissues and has been linked to Rheumatoid arthritis, aging, and osteoarthritis. (jimmunol.org)
  • Collagen is a highly abundant protein that is present throughout the body, where it helps maintain the shape of tissues and organs. (mindbodygreen.com)
  • Type I collagen is the most common in the body, and it provides structure to skin, tendons, bones, ligaments, and other connective tissues. (mindbodygreen.com)
  • article{9a5c9918-f28d-42f7-9e4a-e617d47af020, abstract = {Development of type-II collagen (CII)-induced arthritis (CIA) is dependent on a T-cell mediated activation of autoreactive B cells. (lu.se)
  • Collagen, type VII, alpha 1 has been shown to interact with Laminin 5 and Fibronectin. (wikipedia.org)
  • transmembrane collagen, interacts with integrin a1b1, fibronectin and components of basement membranes like nidogen and perlecan. (news-medical.net)
  • At the same time, the adhesion of H295R cells on polylysine, matrigel, lamimin, fibronectin, and type I-III collagens didn't modify staurosporine-induced apoptosis. (springer.com)
  • Serum Collagen IV concentrations correlate with hepatic tissue levels of collagen IV in subjects with alcoholic liver disease and hepatitis C and fall following successful therapy. (wikipedia.org)
  • Serum Markers for Hepatic Fibrosis in Alcoholic Liver Disease: Which is the Best Marker, Type III Procollagen, Type IV Collagen, Laminin, Tissue Inhibitor of Metalloproteinase, or Prolyl Hydroxylase? (wikipedia.org)
  • This is the collagen of granulation tissue, and is produced quickly by young fibroblasts before the tougher type I collagen is synthesized. (news-medical.net)
  • Collagen Type II Monoclonal Antibody (Clone 20G-12E) specifically recognizes rat and mouse type-II collagen and is suitable for immunohistochemistry of paraffin-embedded cartilage protein tissue sections as well as immunoblotting under non-reducing conditions. (clontech.com)
  • A process for extracting type I collagen from an avian source such as poultry feet that incorporates a fibrillar mass of connective tissue as well as bony tissue to yield a collagen product having useful medical and biotechnology applications. (google.co.uk)
  • The enzyme-treated comminuted material which is rich in collagen is dispersed in an organic acid to cause the fibrillar mass to undergo controlled swelling, after which the mass is separated from the bony tissue and purified to remove non-collangenous material. (google.co.uk)
  • During the aging process, collagen levels deplete in the body, resulting in connective tissue degradation, which manifests as wrinkles, thinning cartilage, and brittle hair. (vitacost.com)
  • This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as well as provide tensile strength to the tissue. (wikipedia.org)
  • Since homologous type II collagen emulsified in oil without bacterial preparations regularly causes the disease, this new animal model of arthritis represents a unique example of experimentally-inducible autoimmunity to a tissue component. (rupress.org)
  • Type I collagen is the most abundant protein in vertebrates and a constituent of the extra cellular matrix in connective tissue of bone, skin, tendon, ligament and dentine. (atlasgeneticsoncology.org)
  • A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. (curehunter.com)
  • In muscle tissue, collagen serves as a major component of the endomysium. (rockland-inc.com)
  • Collagen constitutes one to two percent of muscle tissue, and accounts for 6% of the weight of strong, tendinous muscles. (rockland-inc.com)
  • In addition, Type II is low in hydroxyproline and trace of hydroxylysine, the primary difference in comparison with Type I and III gearing type II to address cartilage tissue properties. (nutritiongeeks.com)
  • The expression of type IV collagen and its integrin receptors were examined in vivo in human pancreatic cancer tissue. (diva-portal.org)
  • Collagen is the major structural protein in connective tissue and the most abundant protein in the human body. (netrition.com)
  • Polymerized Collagen but not methotrexate induced tissue joint regeneration. (hindawi.com)
  • The alpha-3 subunit (COL4A3) of collagen IV is thought to be the antigen implicated in Goodpasture syndrome , wherein the immune system attacks the basement membranes of the glomeruli and the alveoli upon the antigenic site on the alpha-3 subunit becomes unsequestered due to environmental exposures. (wikipedia.org)
  • in the macromolecular network of collagen IV, which provides the scaffold for basement membranes, the molecules are attached and cross-linked via their like end-regions and they interact laterally with their triple-helical domains in a not yet fully understood manner. (nih.gov)
  • Type IV collagen is a major and crucial component of basement membranes. (pnas.org)
  • The alpha 3 protein constituent of type-IV collagen is thought to be the antigen implicated in goodpasture's syndrome , wherein the immune system attacks the basement membranes of the glomeruli and the alveoli . (wikidoc.org)
  • This collagen appears to be largely restricted to structures identifiable as basement membranes. (rockland-inc.com)
  • Type IV collagens are found in basement membranes, where their head-to-head linking (as opposed to the usual parallel linking of collagen fibres) provides strength and an anchoring scaffold. (sciencephoto.com)
  • There seems to be a lot of hype building up for type 3, egg shell membranes. (dogfoodadvisor.com)
  • Mutations to the genes coding for collagen IV lead to Alport syndrome . (wikipedia.org)
  • In the absence of mutations, however, an autoimmune response against type VII collagen can result in an acquired form of this disease called epidermolysis bullosa acquisita. (wikipedia.org)
  • Mutations in each of the three collagen VI genes COL6A1, COL6A2 and COL6A3 cause two main types of muscle disorders: Ullrich congenital muscular dystrophy, a severe phenotype, and a mild to moderate phenotype Bethlem myopathy. (nih.gov)
  • We previously demonstrated that gentamicin produced functional type VII collagen in RDEB cells harboring nonsense mutations. (jci.org)
  • Topical and intradermal gentamicin suppresses nonsense mutations and induces type VII collagen and AFs in RDEB patients. (jci.org)
  • Clinical phenotypes associated with type II collagen mutations. (edu.au)
  • Kannu P, Bateman J, Savarirayan R. Clinical phenotypes associated with type II collagen mutations. (edu.au)
  • Bienkowski, R. S. (1984) Collagen degradation in human lung fibroblasts: extent of degradation, role of lysosomal proteases, and evaluation of an alternate hypothesis. (springer.com)
  • 6 Collagen type I accumulation in the heart depends not only on its production, but also on its degradation, which is performed by proteinases, such as matrix metalloproteinase-1 (MMP-1). (ahajournals.org)
  • MMP mediated type V collagen degradation (C5M) is elevated in ankylosing spondylitis. (biomedsearch.com)
  • CONCLUSIONS: This ELISA is the first for detecting type V collagen degradation. (biomedsearch.com)
  • AS patients had highly elevated levels of MMP mediated type V collagen degradation. (biomedsearch.com)
  • Urinary collagen degradation products as early markers of progressive renal fibrosis. (southernbiotech.com)
  • We describe Western immunoblotting of intact α1(I) collagen using antibodies directed to α1(I) collagen amino and carboxyl propeptides. (springer.com)
  • We demonstrate the direct involvement of increased collagenase activity in the cleavage of type II collagen in osteoarthritic human femoral condylar cartilage by developing and using antibodies reactive to carboxy-terminal (COL2-3/4C(short)) and amino-terminal (COL2-1/4N1) neoepitopes generated by cleavage of native human type II collagen by collagenase matrix metalloproteinase (MMP)-1 (collagenase-1), MMP-8 (collagenase-2), and MMP-13 (collagenase-3). (jci.org)
  • Collagen type I is recognized by type specific anti-collagen antibodies that recognize a native three-dimensional structure. (rockland-inc.com)
  • Anti-Collagen antibodies have been used for indirect trapping ELISA for quantitation of antigen in serum using a standard curve, for Immunoprecipitation and for native (non-denaturing, non-dissociating) PAGE and Western blotting for highly sensitive qualitative analysis. (acris-antibodies.com)
  • For these reasons it is often extremely difficult to generate antibodies with specificities to collagens. (acris-antibodies.com)
  • The development of type specific antibodies is dependent on NON-DENATURED three-dimensional epitopes. (acris-antibodies.com)
  • Antibodies are isolated from rabbit antiserum and are extensively cross-adsorbed by immunoaffinity purification to produce 'type' specific antibodies. (acris-antibodies.com)
  • Will look forward to seeing even more benefits for these collagen capsules. (amzn.com)
  • The purified mass is dried to provide the desired Type I collagen product which may be ground into a powder or formed into a collagen matrix or sponge, depending on the end use therefor. (google.co.uk)
  • Kolla2 is UnHydrolyzed Chicken Sternal Cartilage Collagen Type II powder or liquid concentrate. (nutritiongeeks.com)
  • After hours researching and comparing all models on the market, we find out the Best collagen type 2 powder of 2021. (romanceuniversity.org)
  • Many Collagen brands claim to be, but our Collagen Powder is actually 3rd party certified by the Paleo & Keto Foundation, and non-GMO verified by the IGEN program. (romanceuniversity.org)
  • Revive Natural's Multi-Collagen Protein Powder Mix features the 5 collagen types your body naturally craves, including I, II, III, V and X. (romanceuniversity.org)
  • These defects often cause problems in the biosynthesis of the collagen molecules, their assembly and posttranslational modification process that makes them their final end form of collagen. (news-medical.net)
  • In the current study we examine the ultrastructure and mode of aggregation of type VI collagen molecules in the human trabecular meshwork. (molvis.org)
  • Electron-dense collagen structures were detected in the human trabecular meshwork and identified as collagen type VI assemblies based on the three-dimensional spatial arrangement of the type VI collagen molecules, the 105-nm axial periodicity of the assemblies themselves, and their characteristic double bands, which arose from the globular domains of the type VI collagen molecules. (molvis.org)
  • Vuorio, E. and de Crombrugghe, B. (1990) The family of collagen genes. (springer.com)
  • Both rings and der(22) translocated chromosomes present a same molecular rearrangement that fuses the collagen type I alpha 1(COL1A1) and the platelet-derived growth factor B chain (PDGFB) genes (C). (atlasgeneticsoncology.org)
  • This is the 3rd brand I'm using and this particular multi-collagen peptide supplement interested me because of the added DigeSEB ingredient. (amzn.com)
  • Rated 5 out of 5 by Toni from Excellent Product Collagen has improved the overall feel of my joints and my hair is fuller stronger and shiny. (vitaminworld.com)
  • UC-II® undenatured type II collagen helps rebuild healthy joints. (capsugel.com)
  • Kolla2 -ImmuCell is 100% pure chicken sternum cartilage collagen type II, the most abundant structural protein found in joints. (nutritiongeeks.com)
  • a) As we age, the body s ability to make collagen protein slows down so there is insufficient new collagen to make skin, joints and other parts of the body. (nutritiongeeks.com)
  • Type III collagen works alongside type I in skin, ligaments, blood vessels, and joints too. (mindbodygreen.com)
  • Undenatured collagen administered orally works with a healthy immune system to promote healthy joints by a process called oral tolerization. (jonbarron.org)
  • There have been a number of studies conducted with UC-II on both animals and humans, including research at the Harvard University Medical school -- all of which have shown that the undenatured type II chicken collagen found in UC-II effectively reprograms the immune system to promote healthy joints and increase joint mobility and flexibility. (jonbarron.org)
  • Types 1 and 3 work together to bolster skin, muscles, bone health, and hair while Type 2 makes up the fluids and functions to heal joints and cartilage. (romanceuniversity.org)
  • Collagen is one of the most important nutrients needed to ensure the health and vitality of your skin, hair, tendon, cartilage, bones, and joints. (romanceuniversity.org)
  • This chapter outlines several methods to assess the in vitro production of type I collagen that are employed in our laboratory. (springer.com)
  • Under small shear strains, {\em in vitro} collagen gels exhibit strain-stiffening while maintaining overall network integrity. (aps.org)
  • Type IV collagen, an important component of the basement membrane, is highly expressed by pancreatic cancer cells both in vivo and in vitro. (diva-portal.org)
  • Our data indicate that both human gastric carcinoma cell lines synthesize type 1 collagen in vivo as well as in vitro and suggest that carcinoma cells may play an active role in the formation of stromal collagen in most human carcinomas. (aacrjournals.org)
  • In this thesis, I report a series of studies targeted at elucidating mechanisms of proteostasis for collagen type-1, the most abundant collagen in the human body. (mit.edu)
  • These form the most abundant collagens in vertebrates. (news-medical.net)
  • This is the most abundant collagen of the human body. (news-medical.net)
  • Through its characteristic mechanism of action, called Oral Tolerance, a low dose b-2Cool ® ​ is able to modulate the immune response against endogenous type II collagen in the cartilage. (nutraingredients-usa.com)
  • I have since switched to FitIndex Marine Collagen & haven't experienced any bloating at all thankfully. (amzn.com)
  • Collagen VI is an important component of the extracellular matrix which forms a microfibrillar network that is found in close association with the cell and surrounding basement membrane. (nih.gov)
  • We show that type IV collagen is expressed close to the cancer cells in vivo, forming basement membrane like structures on the cancer cell surface that colocalize with the integrin receptors. (diva-portal.org)
  • The epidermal basement membrane is a composite of separate laminin- or collagen IV-containing networks connected by aggregated perlecan, but not by nidogens. (acris-antibodies.com)
  • Prolyl 3-hydroxylation is a crucial posttranslational modification of collagens. (pnas.org)
  • Anybody here have any success incorporating a collagen supplement into their senior dog's diet? (dogfoodadvisor.com)
  • We developed a composite filament from collagen and silica particles modified to interact with collagen and/or present a laminin epitope (IKVAV) crucial for cell-matrix adhesion and signal transduction. (rsc.org)
  • A collagen may be defined as a protein containing sizable domain(s) of triple-helical conformation. (rockland-inc.com)
  • Collagens are highly conserved throughout evolution and are characterized by an uninterrupted "Glycine-X-Y" triplet repeat that is a necessary part of the triple helical structure. (acris-antibodies.com)
  • Second, I use a quantitative mass spectrometry-based interactomics approach and a novel human cell-based model system to map the components of the wild-type collagen-I proteostasis network. (mit.edu)
  • Newly created type VII collagen varied from 20% to 165% of that expressed in normal human skin and persisted for 3 months. (jci.org)
  • Antibody shows less than 0.1% reactivity with human, mouse, chicken Collagen Type I, rat Collagen Types II, III and V and rat Elastin. (sigmaaldrich.com)
  • CellAdhere™ Type I Collagen, Human, Lyophilized is prepared from extracellular matrix secreted by normal human fibroblasts and is xeno-free. (stemcell.com)
  • We measured the C-telopeptide of type II collagen (CTX-II) level in serum via human CTX-II enzyme-linked immunosorbent assay (ELISA) kit (Elabscience) by using sandwich-ELISA method at 450 nm. (thefreedictionary.com)
  • They concluded that at the nucleotide level, human and rat collagen XXIII alpha 1 show 76% identity. (wikidoc.org)
  • Collagen protein is abundantly present in human. (sigmaaldrich.com)
  • Plus, UC-II® undenatured type II collagen could be formulated for a wide variety of human and pet applications in dietary supplements, food, and beverages. (capsugel.com)
  • Human Collagen type I purified protein standard is used as a control in ELISA and western blot. (rockland-inc.com)
  • Western blot of Human Collagen Type I. Lane 1: Human Collagen Type 1. (rockland-inc.com)
  • Trabecular meshwork was dissected from donor human eyes, and three-dimensional transmission electron microscopy of type VI collagen aggregates was performed. (molvis.org)
  • It was originally identified in pepsin fragments of human aortic intima [ 4 ] and designated as "intima collagen. (molvis.org)
  • Purified Human Type I Collagen (SB Cat. (southernbiotech.com)
  • NeoCell Collagen 2 contains key components to support and maintain youthful skin and healthy joint function. (puritan.com)
  • Jarrow Formulas ® Type ll Collagen Complex provides BioCell Collagen ® , a low molecular weight, water-soluble glycosaminoglycan complex completely derived from chicken sternum cartilage. (jarrow.com)
  • In the skin, the type VII collagen protein is synthesized by keratinocytes and dermal fibroblasts. (wikipedia.org)
  • Accordingly, we postulated that the PPAR-γ ligand, pioglitazone, which is known to modulate oxidative stress, would alter Ang II-induced formation of collagen type I in cardiac fibroblasts. (ahajournals.org)
  • 3,4 Fibroblasts are the major source of collagen in the myocardium. (ahajournals.org)
  • 3,5 Proliferation of cardiac fibroblasts and deposition of collagen are directly associated with both systolic and diastolic (especially the latter) heart failure. (ahajournals.org)
  • Fibroblasts are what help us produce collagen itself, as well as elastin. (mindbodygreen.com)
  • Autoimmunity to type II collagen an experimental model of arthritis. (rupress.org)
  • Herein, we determined whether topical or intradermal gentamicin administration induces type VII collagen and AFs in RDEB patients. (jci.org)
  • The administration of antigens into the anterior chamber (AC) of the eye induces a special form of antigen-specific peripheral immune tolerance termed AC-associated immune deviation (ACAID), which prevents delayed-type hypersensitivity (DTH) responses and other inflammatory responses. (jimmunol.org)
  • Polymerized Collagen and methotrexate/polymerized collagen but not methotrexate alone induces downregulation of CD4 + /IL17A + T cells and upregulation of Tregs and CD4 + /IFN- + T cells. (hindawi.com)
  • Collagen is a complex structural protein that maintains strength and flexibility throughout the body. (vitaminworld.com)
  • The collagen IV C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. (wikipedia.org)
  • b) Collagen fibers lose their moist texture and become rigid. (nutritiongeeks.com)
  • A model of extracellular matrix (ECM) of collagen fibers has been built, in which cells could communicate with distant partners via fiber-mediated long-range-transmitted stress states. (aps.org)
  • By acting probably as a posttranscriptional regulator with a different efficacy on COL2A1 (show COL2A1 ELISA Kits ) and COL1A2 expression, miR (show MLXIP ELISA Kits )-29b can contribute to the collagens imbalance associated with an abnormal chondrocyte phenotype. (antibodies-online.com)
  • One day Dr. Moore read about some studies on chicken collagen which showed that a small amount taken orally could have a preventive effect on rheumatoid arthritis. (prohealth.com)
  • Collagen Type II is sometimes used to induce an animal model of rheumatoid arthritis. (sigmaaldrich.com)
  • Chicken type II collagen (Colloral) is being developed as an oral tolerance therapy for the treatment of rheumatoid arthritis. (clinicaltrials.gov)
  • This open label pilot study will describe the safety of chicken type II collagen added to current anti-inflammatory medications as treatment for patients with uveitis associated with juvenile rheumatoid arthritis. (clinicaltrials.gov)
  • Thus, Polymerized Collagen could be an effective therapeutic agent in early and established rheumatoid arthritis by exerting downregulation of autoimmune inflammation. (hindawi.com)
  • 1 In another study, researchers at Harvard Medical School found that six of ten rheumatoid arthritis patients taking undenatured type II collagen for three months showed substantial improvement, while one patient recovered completely. (jonbarron.org)
  • And finally, in a 90-day, double-blind, placebo-controlled, follow-up study on patients with severe rheumatoid arthritis, Harvard scientists found that 28 patients taking undenatured type II collagen showed significant improvement compared to the placebo group, while four patients recovered completely. (jonbarron.org)
  • For anyone suffering from progressive cartilage damage (which ultimately means anyone suffering from rheumatoid arthritis or long term osteoarthritis), reprogramming the immune system with undenatured type II chicken collagen as found in UC-II is an essential component of his or her joint repair regimen. (jonbarron.org)
  • But thanks to science and our Collagen Joint Complex you can fight this common sign of aging. (iherb.com)
  • What Does Type II Collagen Complex Do? (jarrow.com)
  • Each supplement has a strong suite of additional herbal and specialty ingredients for comprehensive, targeted support, including HEART: Deodorized Garlic, standardized Pomegranate, standardized Hawthorn, CoQ10 as well as JOINT: UC-II type II Collagen complex, standardised Boswellia serrata, organic Burdock, concluded the company. (thefreedictionary.com)
  • 2400 mg Collagen 2 complex. (heb.com)
  • Serum Collagen Type IV for the Assessment of Fibrosis and Resistance to Interferon Therapy in Chronic Hepatitis C". Scandinavian Journal of Gastroenterology . (wikipedia.org)
  • Liver fibrosis and cirrhosis are associated with the deposition of collagen IV in the liver. (wikipedia.org)
  • Increased glomerular and mesangial deposition of collagen IV occurs in diabetic nephropathy and increased urinary levels are associated with the extent of renal injury. (wikipedia.org)
  • In addition there is excess collagen formation and deposition in scleroderma. (news-medical.net)
  • In addition to the above mentioned disorders, excessive deposition of collagen occurs in scleroderma. (news-medical.net)
  • Conceivably, deposition of polymerized type I collagen might reflect a reparative response to control MC replication in glomerular inflammation. (biomedsearch.com)
  • I love that I only have to take Beautiful Ally Collagen by Bluebonnet Nutrition once a day and that it is good quality for the price. (pureformulas.com)
  • The Rat Collagen Type 2 Monoclonal Antibody specifically recognizes rat type-II collagen. (clontech.com)
  • This product reacts with anti-Collagen Type V. Reaction with Rockland's anti-Collagen I, II, III, IV or VI is negligible (typically less than 1% cross reactivity was detected by ELISA). (rockland-inc.com)
  • The proteolytically produced C-terminal fragment of type XVIII collagen is endostatin, a potent antiangiogenic protein. (wikipedia.org)
  • The process must be highly orchestrated by the endoplasmic reticulum's chaperone network, including maintaining newly synthesized collagen polypeptides in an unfolded, non-aggregated, and unassembled form until after the extreme C-terminus adopts its folded structure. (mit.edu)