Collagen Type III: A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Reticulin: A scleroprotein fibril consisting mostly of type III collagen. Reticulin fibrils are extremely thin, with a diameter of between 0.5 and 2 um. They are involved in maintaining the structural integrity in a variety of organs.Platelet Adhesiveness: The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.Extracellular Matrix Proteins: Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).Fibronectins: Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.Collagen Type IV: A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.Collagen Type II: A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Collagen Type V: A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.Fibrillar Collagens: A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE.Collagen Type VI: A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers.Collagen Type XI: A fibrillar collagen found primarily in interstitial CARTILAGE. Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits.Receptors, Collagen: Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI.Procollagen: A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.Collagen Type XVIII: A non-fibrillar collagen found in BASEMENT MEMBRANE. The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage.Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.Cartilage: A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.Collagen Type X: A non-fibrillar collagen found primarily in terminally differentiated hypertrophic CHONDROCYTES. It is a homotrimer of three identical alpha1(X) subunits.Collagen Type XII: A fibril-associated collagen found in many tissues bearing high tensile stress, such as TENDONS and LIGAMENTS. It is comprised of a trimer of three identical alpha1(XII) chains.Basement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Laminin: Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.Hyperlipoproteinemia Type III: An autosomal recessively inherited disorder characterized by the accumulation of intermediate-density lipoprotein (IDL or broad-beta-lipoprotein). IDL has a CHOLESTEROL to TRIGLYCERIDES ratio greater than that of VERY-LOW-DENSITY LIPOPROTEINS. This disorder is due to mutation of APOLIPOPROTEINS E, a receptor-binding component of VLDL and CHYLOMICRONS, resulting in their reduced clearance and high plasma levels of both cholesterol and triglycerides.Collagen Diseases: Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Proteoglycans: Glycoproteins which have a very high polysaccharide content.Decorin: A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.Collagen Type IX: A fibril-associated collagen usually found crosslinked to the surface of COLLAGEN TYPE II fibrils. It is a heterotrimer containing alpha1(IX), alpha2(IX) and alpha3(IX) subunits.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cartilage, Articular: A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.Bacterial Proteins: Proteins found in any species of bacterium.Chondrocytes: Polymorphic cells that form cartilage.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Microbial Collagenase: A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Tendons: Fibrous bands or cords of CONNECTIVE TISSUE at the ends of SKELETAL MUSCLE FIBERS that serve to attach the MUSCLES to bones and other structures.Pepsin A: Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.Collagen Type VIII: A non-fibrillar collagen originally found in DESCEMET MEMBRANE. It is expressed in endothelial cell layers and in tissues undergoing active remodeling. It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains.Cell Adhesion: Adherence of cells to surfaces or to other cells.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Platelet Aggregation: The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.Platelet Membrane Glycoproteins: Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.Platelet Activation: A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.Hydroxylysine: A hydroxylated derivative of the amino acid LYSINE that is present in certain collagens.Cross-Linking Reagents: Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.Cyanogen Bromide: Cyanogen bromide (CNBr). A compound used in molecular biology to digest some proteins and as a coupling reagent for phosphoroamidate or pyrophosphate internucleotide bonds in DNA duplexes.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.

Dipyridamole inhibits TGF-beta-induced collagen gene expression in human peritoneal mesothelial cells. (1/504)

BACKGROUND: Peritoneal matrix accumulation is characteristic of peritoneal fibrosis (PF). Continuous ambulatory peritoneal dialysis (CAPD) patients who had persistent transforming growth factor-beta (TGF-beta) in their drained effluent had an increased risk of PF. We previously reported that TGF-beta stimulates the expression of types I and III collagen mRNA in cultured human peritoneal mesangial cells (HPMCs), which may predispose them to develop PF. Pharmacological interventions to attenuate TGF-beta-stimulated matrix accumulation in HPMC may have therapeutic potential for the treatment of PF. The SMAD family and the extracellular signal-regulated protein kinase (ERK1/2, p44/p42) pathways have been shown to participate in TGF-beta signaling. Our current study identified these signal pathways in HPMCs and investigated the molecular mechanisms involved in the inhibitory effects of dipyridamole on TGF-beta-induced collagen gene expression in HPMCs. METHODS: HPMCs were cultured from human omentum by an enzyme digestion METHOD: Expression of collagen alpha1(I) mRNA was determined by Northern blotting. The SMAD proteins and the ERK1/2 activity were determined by Western blotting. RESULTS: TGF-beta-stimulated collagen alpha1(I) mRNA expression of HPMC was inhibited by dipyridamole in a dose-dependent manner. Smad2 and ERK1/2 were activated in response to TGF-beta; however, TGF-beta had little effect on the protein expression of Smad4. The addition of PD98059, which blocked activation of ERK1/2, suppressed TGF-beta-induced collagen alpha1(I) mRNA expression in a dose-dependent manner. At a concentration that inhibited collagen gene expression (17 microg/mL), dipyridamole suppressed ERK1/2 activation by TGF-beta. In contrast, the same concentration of dipyridamole had no effect on TGF-beta-induced activation of Smad2. CONCLUSION: Dipyridamole inhibits TGF-beta-induced collagen gene expression in HPMC through modulation of the ERK pathway. Our study of dipyridamole may provide therapeutic basis for clinical applications in the prevention of PF.  (+info)

Haploinsufficiency for one COL3A1 allele of type III procollagen results in a phenotype similar to the vascular form of Ehlers-Danlos syndrome, Ehlers-Danlos syndrome type IV. (2/504)

Mutations in the COL3A1 gene that encodes the chains of type III procollagen result in the vascular form of Ehlers-Danlos syndrome (EDS), EDS type IV, if they alter the sequence in the triple-helical domain. Although other fibrillar collagen-gene mutations that lead to allele instability or failure to incorporate proalpha-chains into trimers-and that thus reduce the amount of mature molecules produced-result in clinically apparent phenotypes, no such mutations have been identified in COL3A1. Furthermore, mice heterozygous for Col3a1 "null" alleles have no identified phenotype. We have now found three frameshift mutations (1832delAA, 413delC, and 555delT) that lead to premature termination codons (PTCs) in exons 27, 6, and 9, respectively, and to allele-product instability. The mRNA from each mutant allele was transcribed efficiently but rapidly degraded, presumably by the mechanisms of nonsense-mediated decay. In a fourth patient, we identified a point mutation, in the final exon, that resulted in a PTC (4294C-->T [Arg1432Ter]). In this last instance, the mRNA was stable but led to synthesis of a truncated protein that was not incorporated into mature type III procollagen molecules. In all probands, the presenting feature was vascular aneurysm or rupture. Thus, in contrast to mutations in genes that encode the dominant protein of a tissue (e.g., COL1A1 and COL2A1), in which "null" mutations result in phenotypes milder than those caused by mutations that alter protein sequence, the phenotypes produced by these mutations in COL3A1 overlap with those of the vascular form of EDS. This suggests that the major effect of many of these dominant mutations in the "minor" collagen genes may be expressed through protein deficiency rather than through incorporation of structurally altered molecules into fibrils.  (+info)

Cardiac remodeling after long term norepinephrine treatment in rats. (3/504)

OBJECTIVE: In this study we have tested the hypothesis that degradation of collagen by matrix metalloproteinase 2 (MMP-2) precedes the deposition of extracellular matrix (ECM) after long term norepinephrine (NE) treatment. METHODS: Female Sprague-Dawley rats received continuous i.v. infusion of NE (0.1 mg/kg.h) for 1, 2, 3, 4 and 14 days. Heart function and weight as well as expression of cardiac colligin and of collagen I and III were examined. Furthermore, we have assessed the degradation pathway of collagen by measuring the mRNA and activity of myocardial MMP-2 and tissue inhibitor of metalloproteinase 2 (TIMP-2) as well as the protein level of TIMP-2. RESULTS: NE induced hypertrophy predominantly of the left ventricle (LV) in a time-dependent manner. It increased the mRNAs of colligin, collagen I and III, and of MMP-2 and TIMP-2 as well as MMP-2 activity in two phases: In the initial phase, at 3 and 4 days, the mRNA of colligin and of collagen I and III was elevated predominantly in the LV, MMP-2 and TIMP-2 mRNA, as well as TIMP-2 protein and MMP-activity were increased in both ventricles. The second phase, after 14 days, was characterized by a less pronounced increase in colligin, collagen I and III and in MMP-2 activity which occurred exclusively in the LV. Finally, long-term treatment with NE induced a 37% increase in interstitial fibrosis which was shown to occur exclusively in the LV after 14 days. CONCLUSION: NE treatment induced fibrosis exclusively in the LV which was associated with hypertrophy predominantly of the LV. The elevated MMP-2 activity seems to be necessary for the ECM to adapt to the enlargement of myocytes and to reduce overproduction of collagen.  (+info)

Biophysical characterization of the C-propeptide trimer from human procollagen III reveals a tri-lobed structure. (4/504)

Procollagen C-propeptide domains direct chain association during intracellular assembly of procollagen molecules. In addition, they control collagen solubility during extracellular proteolytic processing and fibril formation and interact with cell surface receptors and extracellular matrix components involved in feedback inhibition, mineralization, cell growth arrest, and chemotaxis. At present, three-dimensional structural information for the C-propeptides, which would help to understand the underlying molecular mechanisms, is lacking. Here we have carried out a biophysical study of the recombinant C-propeptide trimer from human procollagen III using laser light scattering, analytical ultracentrifugation, and small angle x-ray scattering. The results show that the trimer is an elongated molecule, which by modeling of the x-ray scattering data appears to be cruciform in shape with three large lobes and one minor lobe. We speculate that each of the major lobes corresponds to one of the three component polypeptide chains, which come together in a junction region to connect to the rest of the procollagen molecule.  (+info)

Role of protein kinase C-delta in the regulation of collagen gene expression in scleroderma fibroblasts. (5/504)

Working with cultured dermal fibroblasts derived from control individuals and patients with systemic sclerosis (SSc), we have examined the effects of protein kinase C-delta (PKC-delta) on type I collagen biosynthesis and steady-state levels of COL1A1 and COL3A1 mRNAs. Rottlerin, a specific inhibitor of PKC-delta, exerted a powerful, dose-dependent inhibition of type I and type III collagen gene expression in normal and SSc cells. Optimal rottlerin concentrations caused a 70-90% inhibition of type I collagen production, a >80% reduction in COL1A1 mRNA, and a >70% reduction in COL3A1 mRNA in both cell types. In vitro nuclear transcription assays and transient transfections with COL1A1 promoter deletion constructs demonstrated that rottlerin profoundly reduced COL1A1 transcription and that this effect required a 129-bp promoter region encompassing nucleotides -804 to -675. This COL1A1 segment imparted rottlerin sensitivity to a heterologous promoter. Cotransfections of COL1A1 promoter constructs with a dominant-negative PKC-delta expression plasmid showed that suppression of this kinase silenced COL1A1 promoter activity. The results indicate that PKC-delta participates in the upregulation of collagen gene transcription in SSc and suggest that treatment with PKC-delta inhibitors could suppress fibrosis in this disease.  (+info)

Interstitial collagens I, III, and VI sequester and modulate the multifunctional cytokine oncostatin M. (6/504)

The binding of certain growth factors and cytokines to components of the extracellular matrix can regulate their local availability and modulate their biological activities. We show that oncostatin M (OSM), a profibrogenic cytokine and modulator of cancer cell proliferation, specifically binds to collagen types I, III, IV, and VI, immobilized on polystyrene or nitrocellulose. Single collagen chains inhibit these interactions in a dose-dependent manner. Cross-inhibition experiments of collagen-derived peptides point to a limited set of OSM-binding collagenous consensus sequences. Furthermore, this interaction is found for OSM but not for other interleukin-6 type cytokines. OSM binding to collagens is saturable, with dissociation constants around 10(-8) m and estimated molar ratios of 1-3 molecules of OSM bound to one molecule of triple helical collagen. Furthermore, collagen-bound OSM is biologically active and able to inhibit proliferation of A375 melanoma cells. We conclude that abundant interstitial collagens dictate the spatial pattern of bioavailable OSM. This interaction could be exploited for devising collagenous peptide-antagonists that modulate OSM bioactivity in tumor growth and fibrotic disorders like rheumatoid arthritis and hepatic fibrosis.  (+info)

Adenosine regulates the IL-1 beta-induced cellular functions of human gingival fibroblasts. (7/504)

In this study we examined the influence of adenosine on the cellular functions of human gingival fibroblasts (HGF), such as the production of inflammatory cytokines and extracellular matrices (ECM), and the expression and function of adhesion molecules. Concerning the expression of adenosine receptors, RT-PCR analysis revealed that HGF expressed adenosine receptor A1, A2a and A2b, but not A3 mRNA. Ligation of adenosine receptors by adenosine or its related analogue, 2-chloroadenosine (2-CADO), N(6)-cyclopentyladenosine (CPA) or CGS21680 synergistically increased IL-1beta-induced IL-6 and IL-8 production. In terms of ECM expression, adenosine and the adenosine receptor agonists, 2-CADO and CPA, enhanced constitutive and IL-1beta-induced expression of hyaluronate synthase mRNA, but not the mRNA levels of other ECM, such as collagen type I, III and fibronectin. Moreover, the adherence of IL-1beta-stimulated HGF to activated lymphocytes was also inhibited by adenosine, which is in part explained by the fact that adenosine down-regulated the IL-1beta-induced expression of ICAM-1 on HGF. These results provide new evidence for the possible involvement of adenosine in the regulation of inflammatory responses in periodontal tissues.  (+info)

Mast cell chymase inhibits smooth muscle cell growth and collagen expression in vitro: transforming growth factor-beta1-dependent and -independent effects. (8/504)

In the vulnerable areas of fibrous caps of advanced atherosclerotic lesions, chymase-containing mast cells are present. In such areas, the numbers of smooth muscle cells (SMCs) and the content of collagen are reduced. In this in vitro study, we found that the addition of chymase, isolated and purified from rat serosal mast cells, to cultured rat aortic SMCs of the synthetic phenotype (s-SMCs) inhibited their proliferation by blocking the G(0)/G(1)-->S transition in the cell cycle. Rat chymase and recombinant human chymase inhibited the expression of collagen type I and type III mRNA in s-SMCs and in human coronary arterial SMCs. The growth-inhibitory effect of chymase was partially reversed by addition to the culture medium of an antibody capable of neutralizing the activity of transforming growth factor-beta1 (TGF-beta1). Immunocytochemistry showed that the s-SMCs expressed and synthesized extracellular matrix-associated TGF-beta1. On exposure to mast cell chymase, the extracellular matrix-associated latent TGF-beta1 was released and activated, as demonstrated by immunoblotting and by an ELISA with TGF-beta1 type II receptor for capture. When added to s-SMCs, such chymase-released TGF-beta1 was capable of inhibiting their growth. In contrast, the inhibitory effect of chymase on collagen synthesis by s-SMCs did not depend on TGF-beta1. Taken together, the findings support the hypothesis that chymase released from activated mast cells in atherosclerotic plaques contributes to cap remodeling.  (+info)

*Collagen, type III, alpha 1

III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone ... Structure and Function of Collagen Types. Academic Press, Inc. ISBN 0-12-481280-5. "Entrez Gene: COL3A1 collagen, type III, ... GeneReview/NCBI/NIH/UW entry on Ehlers-Danlos Syndrome Type IV Collagen type III at the US National Library of Medicine Medical ... Collagen alpha-1(III) chain is a precursor to collagen III, a protein that is found in extensible connective tissues such as ...

*Collagen, type IX, alpha 3

This gene encodes one of the three alpha chains of type IX collagen, the major collagen component of hyaline cartilage. Type IX ... sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type ... collagen, a heterotrimeric molecule, is usually found in tissues containing type II collagen, a fibrillar collagen. Mutations ... "Entrez Gene: COL9A3 collagen, type IX, alpha 3". GeneReviews/NCBI/NIH/UW entry on Multiple Epiphyseal Dysplasia, Dominant ...

*Collagen, type V, alpha 3

... related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type ... Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in ... type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This ... "Entrez Gene: COL5A3 collagen, type V, alpha 3". van der Rest M, Garrone R (1991). "Collagen family of proteins". FASEB J. 5 (13 ...

*Collagen, type VI, alpha 3

This protein is an alpha chain of type VI collagen that aids in microfibril formation. As part of type VI collagen, this ... one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The alpha 3 ... both Bethlem myopathy and autosomal recessive UCMD patients are heterozygous for mutations in the three type VI collagen alpha ... "Cloning and chromosomal localization of human genes encoding the three chains of type VI collagen". American Journal of Human ...

*Collagen, type IV, alpha 3

2003). "Type-IV collagen related diseases". J. Nephrol. 16 (2): 314-6. PMID 12768082. Torra R, Tazón-Vega B, Ars E, Ballarín J ... Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. ... Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another ... "Entrez Gene: COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)". Hinek A (1995). "Nature and the multiple functions of ...

*Type II collagen

Type I collagen Collagen, type III, alpha 1 Park, Kyung-Su; Park, Min-Jung; Cho, Mi-La; Kwok, Seung-Ki; Ju, Ji Hyeon; Ko, Hyeok ... Type II collagen does form fibrils. This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as ... "Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis". Modern ... Type II collagen is the basis for articular cartilage and hyaline cartilage. It makes up 50% of all protein in cartilage and 85 ...

*Tendinosis

Normal, intact tendon is composed mainly of type I collagen, and type III collagen increases after injury. Another study has ... This report further indicates that a decrease in type I procollagen (and increase in type III collagen and periostin) ... Partial tears heal by the rapid production of disorganized type-III collagen which is weaker than normal tendon.[citation ... Cultures from tendinopathic tendons contain an increased production of type III collagen. Longitudinal sonogram of the lateral ...

*Korff fibers

It consist of type 3 collagen, associated, at least initially, with fibronectin. Microscopic Photo of Korff fibers[permanent ...

*Fibromodulin

It also inhibits fibrillogenesis of collagen type I and collagen type III in vitro. It regulates TGF-beta activities by ... "Structural requirements for fibromodulin binding to collagen and the control of type I collagen fibrillogenesis--critical roles ... Kalamajski S, Oldberg A (2007). "Fibromodulin binds collagen type I via Glu-353 and Lys-355 in leucine-rich repeat 11". J Biol ... Kalamajski S, Oldberg A (Sep 2007). "Fibromodulin binds collagen type I via Glu-353 and Lys-355 in leucine-rich repeat 11". The ...

*Gingival fibers

They are primarily composed of type I collagen, although type III fibers are also involved. These fibers, unlike the fibers of ... There are three groups within which gingival fibers are arranged: dentogingival group - there are three types of fibers within ... However, two other types of fibers have been described in this group:semicircular fibers - fibers that run through the facial ...

*Healing

... and type III collagen is largely replaced by type I. Collagen which was originally disorganized is cross-linked and aligned ... Fibroblasts quickly produce abundant type III collagen, which fills the defect left by an open wound. Granulation tissue moves ... They begin to produce the much stronger type I collagen. Some of the fibroblasts mature into myofibroblasts which contain the ... In order for an injury to be healed by regeneration, the cell type that was destroyed must be able to replicate. Cells also ...

*Diabetic foot ulcer

AGEs are also known to increase synthesis of type III collagen that forms the granulation tissue. AGEs on laminin result in ... laying down new collagen of the subtypes I and III. In the initial events of wound healing, collagen III predominates in the ... AGE cross-linking on type I collagen and elastin results in increased stiffness. ... It is evident from the known collagen assembly that the tensile strength is basically due to fibrillar arrangement of collagen ...

*Reticular fiber

... or type III collagen. Reticular fiber is composed of one or more types of very thin and delicately woven strands of type III ... Reticular fibers, reticular fibres or reticulin is a type of fiber in connective tissue composed of type III collagen secreted ... Today, the term reticulin or reticular fiber is restricted to referring to fibers composed of type III collagen. However, ... Many of these types of collagen have been combined with carbohydrate. Thus, they react with silver stains and with periodic ...

*Paddywhack

... the nuchal ligament is formed with the association of both elastin proteins as well as type III collagen (45%). The collagen ... Most ligaments are mostly made of highly aligned collagen fibres which do not permit stretching. Structurally, ...

*Hepatocyte

... collagen type III) network. The hepatocyte plates are one cell thick in mammals and two cells thick in the chicken. Sinusoids ... For optimal results, culture plates should first be coated with an extracellular matrix (e.g. collagen, Matrigel) to promote ... Stellate (Ito) cells store vitamin A and produce extracellular matrix and collagen; they are also distributed amongst ... doi:10.1016/s1359-6446(01)01712-3. Hamel, F.; Grondin, M. L.; Denizeau, F.; Averill-Bates, D. A.; Sarhan, F. (2006). "Wheat ...

*Stroma (tissue)

There are three types of fibers commonly found within the stroma: collagen type I, elastic, and reticular (collagen type III) ... Stroma is made of various types of stromal cells. Examples of stroma include: stroma of iris stroma of cornea stroma of ovary ... Dense irregular connective tissue - the function of this type is binding at a high tensile strength between tissues to convert ... Loose connective tissue - This type is mainly located under the epithelial membranes and glandular epithelium, attaching the ...

*Ventricular remodeling

Besides, the cardiac interstitium which consisted of largely Type I and Type III collagen fibres are also involved in cardiac ... Fibroblasts, collagen, the interstitium, and the coronary vessels to a lesser extent, also play a role. A common scenario for ... Cardiac collagen is synthesized by fibroblasts and degraded by metalloproteinases. Fibroblasts are activated post MI, leading ... It is an aspect of cardiomyopathy, of which there are many types. Concentric hypertrophy is due to pressure overload, while ...

*Collagen, type XIV, alpha 1

2006). "The elongated first fibronectin type III domain of collagen XIV is an inducer of quiescence and differentiation in ... "Entrez Gene: COL14A1 collagen, type XIV, alpha 1 (undulin)". Schuppan D, Cantaluppi MC, Becker J, et al. (1990). "Undulin, an ... 2005). "Collagen types XII and XIV are present in basement membrane zones during human embryonic development". J. Mol. Histol. ... Tono-Oka S, Tanase S, Miike T, Tanaka H (1996). "Transient expression of collagen type XIV during muscle development and its ...

*Granulation tissue

Initially, it consists of a network of type-III collagen, a weaker form of the structural protein that can be produced rapidly ... This is later replaced by the stronger, long-stranded type-I collagen, as evidenced in scar tissue. The main immune cells ... pulseful on palpation painless when healthy Granulation tissue is composed of tissue matrix supporting a variety of cell types ...

*Classification of Ehlers-Danlos syndrome

Ehlers-Danlos syndrome type III/articular hypermobility syndrome has a glycine 637 to serine substitution in type III collagen ... Type 5 130080 - Type 8 - unspecified gene, locus 12p13 225310 - Type 10 - unspecified gene, locus 2q34 608763 - Beasley-Cohen ... the most common type of all ten types, some of the specific mutations involved have been identified and they can be precisely ... Until 1997 the classification system for EDS included 10 specific types, and also acknowledged that other extremely rare types ...

*Endomysium

... has been shown to contain mainly type I and type III collagen components, and type IV and type V in very minor ... Endomysium combines with perimysium and epimysium to create the collagen fibers of tendons, providing the tissue connection ... The elastic fiber of collagen is the major protein that composes connective tissues like endomysium. ... 219 (3): 1017-26. doi:10.1042/bj2191017. PMC 1153576 . PMID 6743238. Pruessner, H. T. (1998). "Detecting celiac disease in your ...

*Neutrophil collagenase

Unlike EC 3.4.24.7, interstitial collagenase, this enzyme cleaves type III collagen more slowly than type I This enzyme belongs ... Collagenase Hasty, K. (1987). "A., Jeffrey, J. J., Hibbs, M. S. and Welgus, H. G. The collagen substrate specificity of human ...

*Sack-Barabas syndrome

When the structure or production of type III collagen is altered by a mutation in the COL3A1 gene, collagen fibrils cannot be ... The protein determined by the COL3A1 gene is used to assemble larger type III collagen molecules, found mostly in skin, blood ... Barabas A.P. (1967). "Heterogeneity of the Ehlers-Danlos Syndrome: Description of Three Clinical Types and a Hypothesis to ... This condition is now called Ehlers-Danlos syndrome, vascular type [formerly EDS type IV]. Ehlers-Danlos syndrome Sack G (1936 ...

*Pseudolysin

This enzyme catalyses the following chemical reaction Hydrolysis of proteins including elastin, collagen types III and IV, ...

*PCOLCE

Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- ... This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase ... 1994). "Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal ... 1999). "Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal ...

*Catenin

Several types of catenins work with N-cadherins to play an important role in learning and memory (For full article, see ... Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR (October 2011). "A role for collagen XXIII in cancer cell ... "The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related ... For instance, higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened ...
TY - JOUR. T1 - Colorectal cancer metastatic phenotype stimulates production by fibroblasts of N-terminal peptide of type III collagen. T2 - Clinical implications for prognosis. AU - Basso, Daniela. AU - Belluco, Claudio. AU - Mazza, Saverio. AU - Greco, Eliana. AU - Della Rocca, Fosca. AU - Pauletto, Paolo. AU - Nitti, Donato. AU - Lise, Mario. AU - Plebani, Mario. PY - 2001. Y1 - 2001. N2 - In this study we assessed whether the serum levels of the N-terminal peptide of type III collagen (PIIIP), an index of type III collagen synthesis, are influenced by colorectal cancer stage, and whether "in vitro" fibroblast growth and PIIIP production could be altered by tumor tissues obtained from metastatic and nonmetastatic colorectal cancer. 208 colorectal cancer patients (115 colon and 93 rectum) were studied; 54 were stage I, 62 stage II, 37 stage III and 55 stage IV. PIIIP serum levels were significantly higher in stage IV as compared to all other patient groups. The 5-year survival of stage I, ...
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Gentaur molecular products has all kinds of products like :search , AbD \ GOAT ANTI HUMAN COLLAGEN III, Product Type Polyclonal Antibody, Specificity COLLAGEN III, Target Species Human, Host Goat, Format Purified, Isotypes Polyclonal IgG, Applications C, E, IB, Clone \ 133001 for more molecular products just contact us
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Reactome is pathway database which provides intuitive bioinformatics tools for the visualisation, interpretation and analysis of pathway knowledge.
Several peptides were isolated from tryptic digests of insoluble calf aorta matrix by chromatography. Reductive pyridylethylation of a tryptic 15 kDa pool released fragments deriving from the C-terminus of type III collagen. A 50-residue peptide TC(III) was shown by sequence analysis to be the C-terminal peptide from the α1(III)-chain, containing a helical and non-helical region of equal sizes. The peptide was further digested with collagenase to give ColC(III), comprising the complete C-terminal non-helical region of α1(III) including a hydroxylysine in position 16C. The peptide TC(III)×TN(III) was isolated, demonstrating covalent cross-linking between the C-terminal non-helical region of one type III molecule and the N-terminal helical cross-linking region of another. Its digestion with cyanogen bromide yielded the small fragments α1(III)CB3B* and α1(III)CB3C, confirming TN(III) as an N-terminal helical cross-link site. Sequence analysis of both TC(III)×TN(III) and its ...
Moreover, there are some collagen molecules containing sequences of hydrophobic amino acids inserted in the plasma membrane. For example, type XIII and XVII collagens. Collagen type XVII is part of the molecular structure of hemidesmosomes. No matter the type, collagen is synthesized inside the cell as a precursor: the pro-collagen molecule. First, alpha chains are synthesized in the endoplasmic reticulum, where proline becomes hydroxyproline by hydroxylation. Proline and hydroxyproline may be up to 20 % of the alpha chain. GLycosylation (type O-glycosylation) of alpha chains also occurs in the reticulum. At this point, three alpha chains join together by hydrogen bonds to finally form the pro-collagen molecule. Disulfide bridges are also formed between the alpha chains. Pro-collagen molecules are recognized and linked by transmembrane receptors and packaged in COPII coated vesicles. Typical COPII vesicles are 60 to 90 nm in diameter, but COPII vesicles transporting pro-collagen are 500 nm in ...
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actin positive myofibroblasts (activated HSC) which produce a wide variety of collagenous and non-collagenous ECM proteins. Cirrhotic liver contains approximately six times more ECM overall than normal liver, and in the space of Disse collagen types III and V and fibronectin accumulate in early injury.7 In chronic injury here is increasing deposition of collagen types I and IV, undulin, elastin, and laminin.8 Hyaluronan, normally a minor component of the space of Disse, is increased more than eightfold9 and dermatan and chondroitin sulphate and heparan sulphate proteoglycans also increase. Although collagen types I, III, and IV are all increased, type I increases most and its ratio to types III and IV therefore increases.7 10-12 Culture studies have suggested that the neomatrix laid down in the space of Disse may itself contribute to the disease associated alterations in the phenotype of HSC, sinusoidal endothelial cells, and hepatocytes.13-16 With progressive injury ECM spurs link the vascular ...
Technologically superior actives derived from natural sources, provide powerful essential anti-inflammatory and anti-wrinkle action, amplifying collagen III synthesis, with resultant skin plumping, thickening and firming. Healing plants, algae, and a plethora of super peptides promote repair, help reduce wrinkle density and depth, rapidly improving elasticity and providing a lifting effect, long lasting moisturisation, tightening, delaying the appearance of wrinkles by protecting and stimulating healthy elastin and collagen synthesis, and is combined with Mannitol which draws active ingredients into the skin. Skin appears smoother, feels firmer and more youthful ...
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Vascular Ehlers-Danlos Syndrome (VEDS), previously called Ehlers-Danlos syndrome type-IV, is a heterogeneous group of heritable connective tissue disorders characterized by thin, translucent skin, easy bruising, arterial, intestinal, and/or uterine fragility. There is large vessel involvement that leads to arterial rupture often preceded by aneurysm, arteriovenous fistulae, or dissection. Noninvasive imaging studies such as CT angiography and MR angiography are preferred as diagnostic studies for this condition. We are reporting a 4 years old girl who was presented with right sided unilateral convulsions and hypertension. CT angiogram showed stenosis with post-stenotic dilatation of coeliac and superior mesenteric arteries. There were extensive calcified plaques with atherosclerotic changes in the segment of right common iliac artery with aneurysmal dilatation of celiac, superior mesenteric and common iliac artery. Radiological findings were consistent with vascular Ehlers-Danlos syndrome. She was
Ehlers-Danlos syndrome (EDS) is a heterogeneous group of inherited connective tissue disorders that can vary from loose joints to life-threatening complications, depending on type. The vascular form of EDS, which is estimated to affect 1 in 250,000 people
The Ehlers-Danlos syndrome is an inherited disorder of connective tissue, consisting of at least 10 different clinical subtypes. Type IV Ehlers-Danlos syndrome is an autosomal dominant condition characterized by the joint and dermal manifestations as in other forms of the syndrome but also by the proneness to spontaneous rupture of bowel and large arteries. The authors describe their experience with three patients presenting type IV Ehlers-Danlos syndrome: the first presented with several subsequent arterial ruptures, the second with multiple aneurysms, and the third with a dissection of the internal carotid artery. Clinical features, incidence, diagnosis, and treatment of the syndrome are discussed ...
Aortic aneurysms are characterized by abnormal enlargements of the aorta caused by global or localized weakness of the vessel wall. Traditionally, aneurysm formation is believed to involve defects in synthesis or assembly of extracellular matrix (ECM) proteins or accelerated degradation of vascular ECM (reviewed in1,2). For example, mutations in the fibrillin-1 (FBN1) or type III α 1 collagen gene (COL3A1) genes are responsible for Marfan syndrome and vascular Ehlers-Danlos syndrome,3,4 respectively. Mutations in Fbn1 profoundly affect the formation of microfibrils that surround an elastin core and are required for proper assembly of elastic fibers.5 Genetically-engineered mice provide further evidence that the vascular ECM is the critical determinant of aneurysm development, including an allelic series of Fbn1 mutant mice, and mice homozygous for null alleles of the genes encoding lysyl oxidase, a crosslinking enzyme for elastin and collagen, and ECM proteins such as fibulin-4 (Fbln4) and ...
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Australian native plants have a long history of therapeutic use in indigenous cultures, however, they have been poorly studied scientifically. We analysed the effects of 14 plant derived compounds from the species Pilidiostigma glabrum, Myoporum montanum, Geijera parviflora, and Rhodomyrtus psidioides for their potential wound healing properties by assessing their ability to induce or suppress Collagen I and Collagen III expression in human skin fibroblasts in culture. The compound 7-geranyloxycoumarin was able to significantly increase Collagen I (23.7%, p b 0.0002) expression in comparison to control. Significant suppression of Collagen III was observed for the compounds flindersine (11.1%, p b 0.02), and (N-acetoxymethyl) flindersine (27%, p b 0.00005). The implications of these finding is that these compounds could potentially alter the expression of different collagens in the skin allowing for the potential development of new wound healing therapies and new approaches for treating various skin
Elevation of procollagen type III amino terminal propeptide concentration in bronchoalveolar lavage fluid of dogs with idiopathic pulmonary ...
The distribution of collagen type III throughout the pulp tissue from human developing tooth was studied using specific antibodies, immuno-fluorescence as well as immuno- peroxidase labelling for electron microscopy. Our results indicate that type III and type I collagen are present in the pulp. The staining intensity seems to correlate with the relatively high proportions of type III collagen biochemically found in pulp. In addition, type III collagen and reticulin fibres are similarly distributed, except that the Von Korff fibres were never detected with anti-type III collagen antibodies. Correspondingly, at the ultrastructural level, type III collagen appears as fine, branched filaments or electron dense material distributed throughout the tissue and particularly in close association with the plasma membrane of pulp fibroblasts. In contrast, type I collagen appears as typical coarse cross banded fibres. ...
MAA573Mi21, P3NP; N-Propeptide Of Type III Procollagen; Procollagen III Amino Terminal Propeptide | Products for research use only!
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What is ehlers-danlos syndrome eds? Learn about ehlers-danlos syndrome eds symptoms, ehlers-danlos syndrome eds causes, diagnosis, and more.
Result When MI group was Compared with Sham group, the LVMI (2.62±0.16 vs 1.80±0.13, p,0.05), the type I CVF (18.81±2.65 vs 5.01±0.84, p,0.05), type III CVF (3.83±0.38 vs 1.52±0.23, p,0.05) and the I/III ratio (4.96±0.90 vs 3.31±0.40, p,0.05) in NIZ were increased significantly. The expressions of FoxO3a mRNA (0.29±0.05 vs 0.57±0.06, p,0.05) and protein by western-blot (0.28±0.04 vs 0.62±0.07, p,0.05) and by immunohistochemistry (2.30±0.52 vs 3.45±0.50, p,0.05) in NIZ were lower significantly in MI group than those in sham group. Comparing with MI group, the LVMI (2.27±0.08, 2.20±0.23 vs 2.62±0.16, p,0.05), the type I CVF (9.26±1.13, 9.27±1.12 vs 18.81±2.65, p,0.05) and type III CVF (2.37±0.23, 2.38±0.11 vs 3.83±0.38, p,0.05) in NIZ and the I/III ratio (3.98±0.79, 3.89±0.42 vs 4.96±0.90, p,0.05) were decreased significantly in Sim and Ato groups, but higher than those in Sham group, the expressions of FoxO3a mRNA (0.49±0.06, 0.47±0.05 vs 0.29±0.05, p,0.05) and ...
Serum aminoterminal type III procollagen peptide (sPIIIP) has been proposed as an index of hepatic fibroplasia. sPIIIP was retrospectively evaluated in 34 treated and five untreated patients affected by chronic active hepatitis with or without cirrho
Ehlers-Danlos syndrome type X information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
pro-collagen extraction from Mouse Tissues - posted in Protein and Proteomics: Hi, new to the site. I am currently trying to extract procollagen from mouse organs, kidney and liver mostly. I originally used a buffer with extraction buffer of -20mM Tric-HCl -150mM NaCl, -1mM EDTA, -1% Triton X-100. On top of that I add 40ul Protease inhibitor cocktail (sigma) to every 1ml of extract buffer right before I use the buffer for extraction. This is a buffer that I used in the past and hav...
Oskia Super 16 Pro-Collagen Serum er et super aktivt serum, som bekæmper fine linjer, rynker, pigmentering, tør hud og udbrud. Super 16 Serum indeholder 16 aktive ingredienser, heriblandt Bakuchiol fr indiske babchi-frø. Bakuchiol er især kendt for at forhindre nedbrydelsen af kollagen og elastin i huden og for sin evne til at beskytte huden mod solskader, hvilket gør den i stand til at give huden en sund og ungdommelig teint, fuld af glød. Produket er skabt med de effektive nøgleingredienser: Opuntia Ficus-Indica ekstrakt (kaktus) er en stærk antioxidant der blokerer frigivelsen af stressmarkører fra nerveceller til at berolige irriteret hud samtidig med at berolige og opstramme. Vitamin A-palmitat forbedrer udseendet af moden hud. Hyaluronsyre fugter for reducere forekomsten af fine linjer. Vitaminer C & E giver høj antioxidant fordele. Crithmum tangekstrakt hjælper med at afgifte og genoprette træt hud. ... ...
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Ehlers-Danlos syndrome: Ehlers-Danlos syndrome,, rare, heritable disorder characterized by great elasticity of the skin, skin fragility with a tendency to hemorrhage, poor scar formation, and
Im 16.Ive always been active in sports, etc,but was diagnosed with scoliosis at 12. Since scoliosis doesnt cause pain apparently, it took several doctors and a different hospital to discover the real cause- Ehlers-Danlos Syndrome, hypermobility type. It causes weakened joints, etc, and reasonably explains my pain.However, two or so weeks ago, the pain was so severe that i had to be hospitalized and given several narcotics to eliminate it. I didnt recover for two weeks.Does anyone else have this disease or know anything that can eliminate my near-constant back and knee pain? Im willing to try anything at this point. I feel like Im wayyyy too young to be in pain all the time.thanks so much!I wish I could tell you that you are too young for all the pain you have to endure! I was diagnosed with Ehlers-Danlos Syndrome when I was around 30. Before that most doctors said it was in my head.The best thing Ive found to relieve the pain is a jaccuzi. However they can be hard to come by, so there ...
The present invention identified a high affinity binding sequence in collagen type III for the collagen-binding integrin I domains. Provided herein are the methods used to characterize the sequence, the peptides comprising this novel sequence and the use of the peptides in enabling cell adhesion. Also provided herein are methods to identify specific integrin inhibitors, sequences of these inhibitors and their use in inhibiting pathophysiological conditions that may arise due to integrin-collagen interaction ...
Matrix therapy aims to facilitate and potentiate the intrinsic tissue self-regeneration capability by restoring the natural wound microenvironment. In this study, we demonstrate that matrix therapy with OTR4120 reduces diabetic ulcer healing time and improves healing quality by reducing inflammation, increasing angiogenesis, reducing collagen type III, and enhancing the ulcer biomechanical strength restoration.. Excess inflammation, associated with a prolonged persistence of neutrophil infiltration, is a consistent feature of diabetes-impaired wound healing (6). In another study using the same wound model in normal rats, macrophages were only detectable during the first 6 weeks after wounding (14), whereas in the current study, macrophages were detectable during the entire 12-week observation period. This is an additional sign that inflammation resolution in diabetic wound healing is impaired. This impaired resolution is stimulated after OTR4120 treatment. Possible mechanisms of the ...
An extracellular endopeptidase of vertebrate tissues homologous with interstitial collagenase. Digests proteoglycan, fibronectin, collagen types III, IV, V, IX, and activates procollagenase. In peptidase family M10 (interstitial collagenase family ...
Ehlers-Danlos syndrome is a group of inherited disorders that affect your connective tissues - primarily your skin, joints and blood vessel walls. Connective tissue is a complex mixture of proteins and other substances that provides strength and elasticity to the underlying structures in your body.
Ehlers-Danlos syndrome is a group of inherited disorders that affect the connective tissues of the skin, joints and walls of the blood vessels. It is characterized by flexible joints and fragile skin.
Ehlers-Danlos syndrome (EDS) is a group of inherited conditions. These conditions affect the connective tissues. This type of tissue is found all over the body. There are at least 6 different varieties of EDS. They are classified by the type of tissue most affected and how it is inherited.
Ehlers-Danlos syndrome, cardiac valvular form information including symptoms, diagnosis, misdiagnosis, treatment, causes, patient stories, videos, forums, prevention, and prognosis.
A woman with Ehlers-Danlos syndrome explains how she realized that its OK to not be independent in the way she thought she had to be.
This article focuses on a presentation by Dr. Rodney Graham about Ehlers-Danlos Syndrome, better known by the general public as joint-hypermobility. Dr. Graham is a rheumatologist from the U.K. who has devoted much of his career to this specific illness.
Learn more about Ehlers-Danlos Syndrome at Palms West Hospital DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Online Doctor Chat - Ehlers-danlos syndrome, Ask a Doctor about when and why Magnetic resonance imaging is advised, Online doctor patient chat conversation by Dr. Yogesh D
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My teen daughter was at a friends walking and looking at her phone and ran into the wall fracturing her radius. Her wrist was in an odd position that she could not move out of when I picked her up. I ...
hey everyone, I am sure many of you can relate to what Im feeling but sometimes i just feel so alone. I feel like searching for answers to my pain is useless, and that at some point I should just giv...
Keloids come up on the areas of the skin where wounds have initially appeared. When the wound has already healed, it gets covered with something called type III collagen
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McLean, VA (PRWEB) March 05, 2014 -- The Ehlers-Danlos National Foundation (EDNF) is pleased to announce that registration for the worlds largest gathering of
The Driscoll Theory® Newly Revised · The Cause of POTS in Ehlers-Danlos Syndrome and How to Reverse the Process by Diana Driscoll (Author), Ananya De…
TY - JOUR. T1 - Demonstration of type III collagen in the dentin of mice. AU - Nagata, Kengo. AU - Huang, Yu Hsin. AU - Ohsaki, Yasuyoshi. AU - Kukita, Toshio. AU - Nakata, Minoru. AU - Kurisu, Kojiro. PY - 1992/1/1. Y1 - 1992/1/1. N2 - It has been reported that, although type III collagen is present in human dentin where there is dentinogenesis imperfecta and in reparative dentin, it is absent in normal dentin. In a preliminary study, however, we observed evidence showing that small amounts of fibers showing positive labeling for type III collagen are present in the molars of normal mice. In the present study, in order to localize type III in normal dentin, immunofluorescent and immunoelectron microscopic examinations of the molars of normal mice were carried out using affinity-purified antibodies to mouse type III and type I collagen. The fibers positive for type III collagen were much more frequently observed in the root than in the crown. These fibers ran in peritubular dentin or near that ...
In acute lung injury (ALI), elevation of procollagen type III (PC III) occurs early and has an adverse impact on outcome. We examined whether different high-inflation strategies of mechanical ventilation (MV) in oleic acid (OA) ALI alter regional expression of PC III. We designed an experimental, randomized, and controlled protocol in which rats were allocated to two control groups (no injury, recruited [alveolar recruitment maneuver after tracheotomy without MV; n = 4 rats] and control [n = 5 rats]) or four injured groups (one exposed to OA only [n = 10 rats] and three OA-injured and ventilated). The three OA-injured groups were ventilated for 1 hour according to the following strategies: LVHP-S (low volume-high positive end-expiratory pressure [PEEP], supine; n = 10 rats, tidal volume [VT] = 8 ml/kg, PEEP = 12 cm H2O), HVLP-S (high volume-low PEEP, supine; n = 10 rats, VT = 20 ml/kg, PEEP = 5 cm H2O), and HVLP-P (high volume-low PEEP, prone; n = 10 rats). Northern blot analysis for PC III and
Introduction - Clinical approach to inherited connective disease - Cardiovascular phenotypes in connective tissue disorders - Marfan syndrome: general features - Marfan syndrome: molecular genetics - Diagnosis of Marfan syndrome - Management of Marfan syndrome - Vascular Ehlers-Danlos syndrome (EDS IV) - Thoracic aortic aneurysms - Abdominal aortic aneurysms ...
The crucial role of vWF in adhesion to the vessel wall at high shear rates is well established. vWF is present in subendothelium deposited by endothelial cells43 44 and binds to the subendothelium from the circulation.4 The actual binding protein(s) has not been completely identified, but collagen type VI is a strong candidate.45 46 Platelets also adhere to connective tissue in deeper layers of the vessel wall and to the connective tissue of atherosclerotic tissue.47 This process is mediated by binding of vWF from the circulation to collagen types I and III, which mediate platelet adhesion at high shear rates.9 This interaction is essentially different from the binding of vWF to subendothelium.48 We studied the properties of vWF as a single adhesive molecule to shed more light on the question of how far properties of vWF can affect overall adhesion to the vessel wall. We also studied the mediation of platelet adhesion to collagen by adsorbed vWF. The comparison between the two conditions may ...
Elemis Pro-Collagen Advanced Eye Treatment is an advanced eye treatment that targets fine lines and wrinkles around the delicate eye area. Helps smooth and firm for a more youthful appearance. This is the 15ml retail size of Elemis Pro-Collagen Advanced Eye Treatment.
Collagen types I, II, and III. (A-D) Collagen type I, (E-H) collagen type II, (I-L) collagen type III (A, E, I) ACL from young normal knee; (B, F, J) ACL from a
Treatment of rat pups with hyperoxia-induced lung injury, an in vivo model for experimental BPD (41), with metformin prolongs survival; reduces lung injury by attenuating lung inflammation, coagulation, septal thickness, and collagen III expression; and stimulates vascularization. Metformin had no beneficial effects on alveolarization, capillary alveolar leakage, arterial medial wall thickness (PAH), and RVH, and no adverse effects on normal lung and heart development. These data demonstrate that metformin may be a suitable candidate to reduce lung inflammation, coagulation, and fibrosis in preterm infants with severe BPD.. Metformin is a potent antidiabetic drug that is commonly used in type 2 diabetic patients to lower glucose levels in the circulation. Compared with other treatment modalities for type 2 diabetes, patients treated with metformin were protected against mortality in cardiac disease and had less cancer, suggesting that metformin has various biological functions other than its ...
Summary. "Ehlers-Danlos Syndrome is a rare disorder, comprising a group of related inherited disorders of connective tissue, resulting from underlying abnormalities in the synthesis and metabolism of collagen. This proposal is specifically concerned with Ehlers-Danlos syndrome classic type (formerly Types I-III), which is characterized by joint hypermobility and susceptibility to injury/arthritis, skin and vascular problems (including easy bruising, bleeding, varicose veins and poor tissue healing), cardiac mitral valve prolapse, musculo-skeletal problems (myopathy, myalgia, spinal scoliosis, osteoporosis), and susceptibility to periodontitis. No treatment is currently available for this disorder. The novel aspect of this proposal is based on: (i) increasing scientific evidence that nutrition may be a major factor in the pathogenesis of many disorders once thought to result from defective genes alone; (ii) the recognition that many of the symptoms associated with Ehlers-Danlos syndrome are also ...
Consistent with expectations, we have shown that in the mouse model of collagen III haploinsufficiency chronic MMP inhibition by doxycycline treatment prevented increased MMP activity in the carotid artery and the skin present in untreated HT mice. The normalization of MMP activity was accompanied by partial normalization of collagen content in the tunica media of the abdominal aorta in HT mice. This mild increase in collagen accumulation seems to be sufficient to strengthen the vessel, because the increase in stress-induced vessel pathology in untreated HT mice was prevented by doxycycline treatment. Therefore, on the basis of these results, doxycycline therapy might be considered as a treatment for vEDS, at least of the haploinsufficient type.. The rationale for the only available preventive strategy for vEDS by β1-AR blocker was mainly mechanical, to reduce the arterial wall stress by controlling the rate of increase of pressure over time in the pulse wave (dP/dt) and thus to reduce "wearing ...
The myocardium contains collagen matrix that is a major determinant of its architecture, structural integrity, and mechanical properties. This fibrillar matrix consists primarily of type I and type III collagens having epimysial, perimysial, and endomysial components. The present study shows the alteration of collagen phenotypes during the evolution of hypertensive hypertrophy. Therapy with captopril, an angiotensin-converting enzyme inhibitor that regresses cardiac hypertrophy, not only reduces the total amount of collagen but reverses the altered distribution of type I and type III collagen. In normotensive rats, captopril did not significantly reduce collagen content or alter the ratio of type I to type III collagen. ...
My Angel : A true, personal story from the experience, I Have Ehlers-danlos Syndrome Type 3. I am an mother of four children. My second child a girl named Angel. She is 10 years old and has been diagnosed with EDS. It was very apparent at birth that there was something different about her....
Firmer, smoother skin is yours with Elemis Pro-Collagen Marine Cream. Clinically proven to wipe away the signs of wrinkles in just 14 days, this ultra-hydrating formula brings skin to a new level of radiance. With Padina Pavonica, Ginkgo Biloba, Chloerella, and Rose and Mimosa absolutes, it pumps skin full of moisturizing nutrients to visibly shift skin from aging to amazing. Skin feels more supple, firm and full of elasticity with this brilliant anti-aging cream.. Benefits:. ...
Elemis Pro-Collagen Advanced Eye Treatment is a light-weight eye serum that helps to smooth and firm eye contours, targeting fine lines and wrinkles for a more youthful appearance.
PROCOLLAGEN TYPE III N-TERMINAL PEPTIDE (P3NP) AND LEAN MASS: A CROSS-SECTIONAL STUDY. S.D. Berry, V.S. Ramachandran, P.M. Cawthon, P. Gona, R.R. McLean, L.A. Cupples, D.P. Kiel. J Frailty Aging 2013;2(3):129-134. Show summaryHide summary. Background: Procollagen type III N-terminal peptide (P3NP) is released during collagen synthesis in muscle. Increased circulating P3NP is a marker not only of muscle growth, but also of muscle repair and fibrosis. Thus, P3NP may be a potential biomarker for sarcopenia. Objective: To determine the association between plasma P3NP and lean mass and strength. Design, Setting, and Participants: A cross-sectional study of men and women from the Framingham Offspring Study. Participants included a convenience sample of 687 members with a measure of plasma P3NP and lean mass, and 806 members with P3NP and quadriceps strength assessment. Measurements: Linear regression was used to estimate the association between total and appendicular lean mass and plasma P3NP, and ...
More than 320 mutations in the COL3A1 gene cause the Vascular Type of Ehlers-Danlos Syndrome (EDS). Only a few of these mutations have been seen in more than one family. The mutations alter the structure and production of type III procollagen molecules. As a result, a large percentage of type III collagen molecules are assembled incorrectly or the amount of type III collagen is greatly reduced ...
While collagen type I (Col-I) is commonly used as a structural component of biomaterials, collagen type III (Col-III), another fibril forming collagen ubiquitous in many soft tissues, has not previously been used. In the present study, the novel concept of an injectable hydrogel with semi-interpenetrating polymeric networks of heterotypic collagen fibrils, with tissue-specific Col-III to Col-I ratios, in a glycol-chitosan matrix was investigated. Col-III was introduced as a component of the novel hydrogel, inspired by its co-presence with Col-I in many soft tissues, its influence on the Col-I fibrillogenesis in terms of diameter and mechanics, and its established role in regulating scar formation ...
Comment: This important study demonstrated the importance of leukocytes infiltration in the wall and valves of patients with primary venous insufficiency, and the morphologic valvular changes associated with varicose veins. Sansilvestri-Morel P, Rupin A, Badier-Commander C, Kern P, Fabiani JN, Verbeuren TJ, Vanhoutte PM. Imbalance in the synthesis of collagen type I and collagen type III in smooth muscle cells derived from human varicose veins. J Vasc Res 2001;38:560-8.. PMID: 11740155 ...
Save 10% Ancient Nutrition - Dr. Axe Multi Collagen Protein 90 Capsules Dr. Axe Multi Collagen Protein Powder 5 Types of Food Source Collagen Type I, II, III, V and X Skin - Gut - Joint* Powered By Grass-Fed Beef and Chicken Bone Broth Collagen Easy To Swallow Capsules Dr. Axe Multi Collagen Formula is uniquely formulated with 5 Types of Food Source Collagen - specifically designed to provide your body with the primary building blocks it needs for: Promoting healthy skin* Supporting healthy digestive function* Supporting healthy joints*
Could you imagine living in constant, chronic pain? Try to picture waking up experiencing agonizing pain; envision going about your day hurting, and then going back to sleep at night, the way you felt when you woke up, or possibly worse. Every day, every hour, every minute, every second. Now attempt to imagine not being able to get rid of that pain, no matter what you do. Its always there.. This is the reality that Lancaster resident Karley Hill lives in. She has a type of a disease called Ehlers-Danlos Syndrome (EDS), an inherited disorder that affects about 1 in 5,000 people and is caused by faulty collagens. And when we heard about Karley through someone at the church, the church school jumped at the opportunity to make Karley the focus of our Advent project this year. We started by selling beautiful poinsettias at the church; buyers had the option of buying them for themselves and/or donating some to the church (I would like to mention that the back of our mini-van looked so pretty on the ...
Learn more about Ehlers-Danlos Syndrome at Medical City Plano DefinitionCausesRisk FactorsSymptomsDiagnosisTreatmentPreventionrevision ...
Please ask any questions you may have about this specific product in the field below.. Your question(s) and our corresponding answer(s) will not be confidential and will be posted publically on this specific product page.. Additionally, PureFormulas is unable to directly recommend products in relation to specific health conditions. Please contact your trusted healthcare practitioner for direct product recommendations.. If you have any general questions regarding orders or our policies and programs, please contact our Customer Happiness Team @ 1.800.383.6008. If you are pregnant, nursing, taking any medications or have any medical condition, consult your doctor before use. Your healthcare professional is the best source for guidance before beginning an exercise or nutritional supplement program.. ...
In the following, we report investigations of the dependencies of the structural, optical and electrical characteristics of InN thin films grown by MOCVD on the growth temperature. The layer thicknesses range from 70 to 400 nm. Their carrier concentrations range from 7 x 10 18 to 4 x 10(19) cm(-3). Hall mobility values from 150 to 1300 cm(2)/V/s were determined in these films. The variation of the growth temperature and V/III ratio brought about different growth modes and rates. Using TEM, in addition to measuring layer thickness, we also determined the growth mode along with the structural quality of the InN layers. The surface roughness was obtained from AFM measurements. The layer crystalline quality was also investigated by means of X-ray diffraction in the rocking mode. Photoluminescence measurements performed at room temperature and at 7 K gave emission at around 0.7 eV. (C) 2004 Elsevier Ltd. All rights reserved.. Keywords: III-NITRIDES. ...
Rabbit Polyclonal Anti-Collagen III alpha 1/COL3A1 Antibody [Biotin]. Validated: WB, ELISA, IHC, IHC-P, IP. Tested Reactivity: Human, Mouse, Rat, and more. 100% Guaranteed.
human platelet receptor for type III collagen: MW 68-72 kDa; platelet receptor involved in platelet interaction with type III collagen, localized within platelet lipid rafts where it could interact with other platelet receptors for collagen (GP VI and alpha2beta1 integrin) for efficient platelet activation
Arterial dissection is a rare vascular wall disease. ECM disorganisation is suggested to be a predisposing factor. Many ECM proteins are candidates to induce this vascular wall fragility. Some of them, such as collagen III or fibrillin 1, are clearly related to connective disorders with vascular abnormalities. For example, in the Ehlers-Danlos syndrome type IV, related to an α-1 chain mutation in collagen III, disorganisation of the collagen network results in aneurysms and dissections of the coronary and cervical arteries.5 On the other hand, Marfans syndrome, related to a fibrillin-1 mutation, leads to elastic fibre disorganisation that results in aneurysms or coronary and cervical artery dissection.6 However, ECM diseases are a heterogeneous group and most of cases are not related to a known inherited genetic disorder of connective tissue.. Skin is a connective tissue that allows non-invasive investigations of ECM diseases. Skin ECM disorganisation without identified disease was previously ...
To evaluate whether abnormal production of type III collagen, the characteristic biochemical feature of patients with the type IV Ehlers-Danlos syndrome, consistently predisposes to mitral valve prolapse, we evaluated the family of a proband with classic type IV Ehlers-Danlos syndrome. Production of type III collagen was assessed with the use of cultured skin fibroblasts. Mitral valve prolapse was detected by M-mode and two-dimensional echocardiography. Biochemical abnormalities in the production of type III collagen and echocardiographic findings of mitral valve prolapse were completely concordant. All patients with abnormal production of type III collagen had mitral valve prolapse and all subjects with normal production of type III collagen had entirely normal echocardiograms. Six of the eight patients with abnormal production of type III collagen had subtle cutaneous abnormalities. The consistent association of abnormal production of type III collagen and mitral valve prolapse in this family ...
COL1A1 Type I collagen is a member of group I collagen (fibrillar forming collagen). Defects in COL1A1 are the cause of Caffey disease (CAFFD); also known as infantile cortical hyperostosis. Caffey disease is characterized by an infantile episode of massive subperiosteal new bone formation that typically involves the diaphyses of the long bones, mandible, and clavicles. The involved bones may also appear inflamed, with painful swelling and systemic fever often accompanying the illness. The bone changes usually begin before 5 months of age and resolve before 2 years of age. Defects in COL1A1 are a cause of Ehlers-Danlos syndrome type 1 (EDS1); also known as Ehlers-Danlos syndrome gravis. EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS1 is the severe form of classic Ehlers-Danlos syndrome. Defects in COL1A1 are the cause of Ehlers-Danlos syndrome type 7A (EDS7A); also known as autosomal dominant ...
The steady-state level of α1(I) collagen mRNA is regulated by amino acid availability in human lung fibroblasts. Depletion of amino acids decreases α1(I) collagen mRNA levels and repletion of amino acids induces rapid re-expression of α1(I) mRNA. In these studies, we examined the requirements for individual amino acids on the regulation of α1(I) collagen mRNA. We found that re-expression of α1(I) collagen mRNA was critically dependent on cystine but not on other amino acids. However, the addition of cystine alone did not result in re-expression of α1(I) collagen mRNA. Following amino acid depletion, the addition of cystine with selective amino acids increased α1(I) collagen mRNA levels. The combination of glutamine and cystine increased α1(I) collagen mRNA levels 6.3-fold. Methionine or a branch-chain amino acid (leucine, isoleucine or valine) also acted in combination with cystine to increase α1(I) collagen mRNA expression, whereas other amino acids were not effective. The prolonged ...
The immunolocalization of type I, III and IV collagens and fibronectin in two rat glioma cell lines in vitro (BT4C and BT4Cn) is described. In addition, antibodies against denatured type I and III collagens were used to study breakdown products of native type I and III collagens. For the BT4C cells, the extracellular matrix expression in monolayer cultures and in multicellular tumor spheroids was compared. Type IV collagen was strongly expressed in BT4C tumor spheroids but was negative in the corresponding monolayer cultures. Denatured type I collagen was found both in monolayers and in spheroids of BT4C, suggesting either a rapid turnover (i.e., synthesis and immediate breakdown) of type I collagen or an altered collagen gene transcription. Both cell lines were negative for native type I and III and denatured type III collagen.. Fibronectin was strongly expressed in both cell lines.. Supporting the immunofluorescence data, the hydroxyproline content in the tumor spheroids was twice the amount ...
Identification of these connective tissue disorder patients during initial evaluation is key to devising treatment strategies that mitigate acute presentations, reduce future events in contiguous aortic segments, and avoid the need for secondary intervention. Medium-sized arteries (usually the branches of aorta) are more commonly affected in Vascular Type Ehlers-Danlos Syndrome and uniquely in the cervical arteries of Loeys-Dietz Syndrome, versus the large vessel aortopathy of Marfan Syndrome, Loeys-Dietz Syndrome, and familial thoracic aortic aneurysm and dissection. Vascular Type Ehlers-Danlos Syndrome patients with acute presentations are among the most difficult to manage, and percutaneous endovascular embolisation is our preferred management technique. Open surgical reconstructions and large diameter sheath insertions are at best difficult and hazardous, leading to great anxiety concerning vascular isolation, dissection, and clamping. If confronted with vascular disintegration, proximal ...

The mRNAs for the three chains of human collagen type XI are widely distributed but not necessarily co-expressed: implications...The mRNAs for the three chains of human collagen type XI are widely distributed but not necessarily co-expressed: implications...

... the mRNAs for all three alpha chains of collagen type XI were not co-expressed, but collagen alpha 1(XI) and alpha 2(XI) mRNAs ... Expression of mRNAs for all three genes of collagen type XI is not restricted to cartilage but is widespread. However, in some ... The mRNAs for the three chains of human collagen type XI are widely distributed but not necessarily co-expressed: implications ... The mRNAs for the three chains of human collagen type XI are widely distributed but not necessarily co-expressed: implications ...
more infohttp://www.biochemj.org/content/311/2/511

Serum carboxy terminal propeptide of type I procollagen to amino terminal propeptide of type III procollagen ratio is a better...Serum carboxy terminal propeptide of type I procollagen to amino terminal propeptide of type III procollagen ratio is a better...

... mainly with hepatitis B related with progression to liver cirrhosis were included for an assay of serum collagen markers: PICP ... amino terminal propeptide of type III procollagen), and 7S-IV (7S-domain type IV collagen). PICP is increased in 20% of chronic ... Weigand K, Zaugg P-Y, Frei A, Zimmermann A: Long term follow up of theN-terminal propeptide of collagen type III in serum of ... Eriksson S, Zettervall O: TheN-terminal propeptide of collagen type III in serum as a prognostic indicator of primary biliary ...
more infohttps://link.springer.com/article/10.1007/BF02063936

Cells  | Free Full-Text | Decellularized Tendon Extracellular Matrix-A Valuable Approach for Tendon Reconstruction? | HTMLCells | Free Full-Text | Decellularized Tendon Extracellular Matrix-A Valuable Approach for Tendon Reconstruction? | HTML

... and the applicable cell types will be thoroughly discussed. Encouraging in vivo results using cell-free ECM, as, for instance, ... type III collagen often dominates, which is of lesser strength compared with type I collagen [11]. Another strategy in tendon ... Tenocytes from ruptured and tendinopathic achilles tendons produce greater quantities of type III collagen than tenocytes from ... collagen-rich neo-matrix consisting of parallel aligned type I collagen fibers. In tendon repair tissue and tissue engineered ...
more infohttp://www.mdpi.com/2073-4409/1/4/1010/htm

Tendon explant cultures to study the communication between adipose stem cells and native tendon niche | 3Bs Research Group in...Tendon explant cultures to study the communication between adipose stem cells and native tendon niche | 3B's Research Group in...

Moreover, hASCs were spontaneously more elongated in co-cultures and the deposition of collagen type III and tenascin-C by ... The secretion of MMPs was evaluated at day 3. The behavior of hASCs was assessed regarding cell elongation and extracellular ... The paracrine communication enhanced collagenolytic activity of MMPs in co-cultures at day 3, in comparison to hASCs alone or ...
more infohttps://3bs.uminho.pt/publication/tendon-explant-cultures-study-communication-between-adipose-stem-cells-and-native-tendon

JCI -
TGF-β1 induces bone marrow reticulin fibrosis in hairy cell leukemiaJCI - TGF-β1 induces bone marrow reticulin fibrosis in hairy cell leukemia

In addition, BM plasma of HCL patients increased the synthesis of type I and type III procollagens, the main components of ... Ex vivo studies demonstrated that TGF-β1 significantly enhances the production and deposition of reticulin and collagen fibers ... Active TGF-β1 correlated significantly with grades of BM fibrosis, infiltration with HCs, and serum procollagen type III ... cells of two HCL patients compared with BMMCs of three HDs and PBMCs (lanes 9 and 10) and BMMCs (lanes 11 and 12) of B-CLL ...
more infohttps://gczp123.com.mobile.jci.org/articles/view/19540/figure/1

Collagen, type III, alpha 1 - WikipediaCollagen, type III, alpha 1 - Wikipedia

III, and XI), fibril-associated collagen (type IX), and network-forming collagen (type X) cause a spectrum of diseases of bone ... Structure and Function of Collagen Types. Academic Press, Inc. ISBN 0-12-481280-5. "Entrez Gene: COL3A1 collagen, type III, ... GeneReview/NCBI/NIH/UW entry on Ehlers-Danlos Syndrome Type IV Collagen type III at the US National Library of Medicine Medical ... Collagen alpha-1(III) chain is a precursor to collagen III, a protein that is found in extensible connective tissues such as ...
more infohttps://en.wikipedia.org/wiki/Collagen,_type_III,_alpha_1

WikiGenes - COL3A1 - collagen, type III, alpha 1WikiGenes - COL3A1 - collagen, type III, alpha 1

... type I collagen) in valve interstitial cells [27].. *The gene for the alpha 1 (III) chain of type III collagen, COL3A1, has ... Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Liu, X., Wu, H., Byrne, ... The human type II collagen gene, COL2A1, has been assigned to chromosome 12, the type III gene, COL3A1, to chromosome 2, and ... BACKGROUND: Ehlers-Danlos syndrome type IV, the vascular type, results from mutations in the gene for type III procollagen ( ...
more infohttps://www.wikigenes.org/e/gene/e/1281.html

human platelet receptor for type III collagen
     Summary Report | CureHunterhuman platelet receptor for type III collagen Summary Report | CureHunter

... platelet receptor involved in platelet interaction with type III collagen, localized within platelet lipid rafts where it could ... interact with other platelet receptors for collagen (GP VI and alpha2beta1 integrin) for efficient platelet activation ... human platelet receptor for type III collagen: MW 68-72 kDa; ... Collagen Receptors: 185*human platelet receptor for type III ... human platelet receptor for type III collagen. Subscribe to New Research on human platelet receptor for type III collagen ...
more infohttp://www.curehunter.com/public/keywordSummaryC519344-human-platelet-receptor-for-type-III-collagen.do

https://lib.ugent.be/catalog/pug01:8540385https://lib.ugent.be/catalog/pug01:8540385

a Type III collagen: a major fibrillar collagen with major issues 260. a Ghent, Belgium b Ghent University. Faculty of Medicine ... Type III collagen: a major fibrillar collagen with major issues Sanne Dhondt Public defense: 2017-12-15 16:00 ... 2017). Type III collagen: a major fibrillar collagen with major issues. Ghent University. Faculty of Medicine and Health ... Type III collagen: a major fibrillar collagen with major issues. Author:. Dhondt, Sanne GE02 biblio orcid. Malfait, Fransiska ...
more infohttps://lib.ugent.be/catalog/pug01:8540385

Cross-link analysis of the C-telopeptide domain from type III collagen | Biochemical JournalCross-link analysis of the C-telopeptide domain from type III collagen | Biochemical Journal

Sequence analysis of both TC(III)×TN(III) and its collagenase-derived cross-linked peptide ColC(III)×TN(III) established the 4D ... Cross-link analysis of the C-telopeptide domain from type III collagen. W. HENKEL ... Reductive pyridylethylation of a tryptic 15 kDa pool released fragments deriving from the C-terminus of type III collagen. A 50 ... Cross-link analysis of the C-telopeptide domain from type III collagen ...
more infohttp://www.biochemj.org/content/318/2/497

Nitrated type III collagen as a biological marker of nitric oxide-mediated synovial tissue metabolism in osteoarthritis.Nitrated type III collagen as a biological marker of nitric oxide-mediated synovial tissue metabolism in osteoarthritis.

We investigated the nitration of type III collagen, a major constituent ... We investigated the nitration of type III collagen, a major constituent of synovial membrane, in knee OA. METHODS: A polyclonal ... RESULTS: Competition experiments using various nitrated and un-nitrated type III collagen and derived sequences, showed that ... Nitration of tyrosine residues of type III collagen N-telopeptide is increased in the synovial tissue of patients with knee OA ...
more infohttp://www.biomedsearch.com/nih/Nitrated-type-III-collagen-as/19467351.html

Fragments of Citrullinated and MMP-degraded Vimentin and MMP-degraded Type III Collagen Are Novel Serological Biomarkers to...Fragments of Citrullinated and MMP-degraded Vimentin and MMP-degraded Type III Collagen Are Novel Serological Biomarkers to...

Methods: Serum biomarkers of degraded collagens I, III-IV [C1M, C3M, and C4M], collagen type 1 and IV formation [P1NP, P4NP], ... Fragments of Citrullinated and MMP-degraded Vimentin and MMP-degraded Type III Collagen Are Novel Serological Biomarkers to ... Fragments of Citrullinated and MMP-degraded Vimentin and MMP-degraded Type Final publishers version, 849 KB, PDF document ...
more infohttps://www.rug.nl/research/portal/publications/fragments-of-citrullinated-and-mmpdegraded-vimentin-and-mmpdegraded-type-iii-collagen-are-novel-serological-biomarkers-to-differentiate-crohns-disease-from-ulcerative-colitis

Topical Application of Cleome viscosa Increases the Expression of Basic Fibroblast Growth Factor and Type III Collagen in Rat...Topical Application of Cleome viscosa Increases the Expression of Basic Fibroblast Growth Factor and Type III Collagen in Rat...

Collagen type III, present in remodeling wound tissues, is produced by the proliferating young fibroblasts under the influence ... Topical Application of Cleome viscosa Increases the Expression of Basic Fibroblast Growth Factor and Type III Collagen in Rat ... viscosa inducedalteration in fibroblast growth factor and its effect on Smad-mediated collagen (type III) production in Wistar ... β-Smad-mediated collagen production cascade [30]. Intracellular Smad family protein (TGF-β type I receptor kinases substrate) ...
more infohttps://www.hindawi.com/journals/bmri/2014/680879/

Type 3 Collagen | City Laser ClinicType 3 Collagen | City Laser Clinic

... other types of collagen & more with expert information from us. ... Collagen is important, but how much do you know about it? Learn ... Type XII - Found alongside and interacts with types I and III;. The Chemistry of Collagen. Collagen is unlike most proteins, it ... Types of Collagen. Collagen occurs in types and not just in the skin. Collagen is part of most body tissues including blood ... Type III Collagen. So it may be easy to conclude that getting more collagen into our skin will lead to a dramatic improvement ...
more infohttp://www.citylaserclinic.com.au/other-services/type-3-collagen/

Some patients with intracranial aneurysms have a reduced type III/type I collagen ratio: a case control studySome patients with intracranial aneurysms have a reduced type III/type I collagen ratio: a case control study

... Journal. ... Document type. Article. Faculty. Faculty of Medicine (AMC-UvA). Language. Undefined/Unknown. Note. P. v.d. Berg input. ...
more infohttp://dare.uva.nl/search?metis.record.id=130868

Type III collagen is important for collagen fibrillogenesis and for dermal and cardiovascular developmentType III collagen is important for collagen fibrillogenesis and for dermal and cardiovascular development

... Sanne Dhondt (UGent ... "Type III Collagen Is Important for Collagen Fibrillogenesis and for Dermal and Cardiovascular Development." European Journal of ... "Type III Collagen Is Important for Collagen Fibrillogenesis and for Dermal and Cardiovascular Development." In European Journal ... 2015). Type III collagen is important for collagen fibrillogenesis and for dermal and cardiovascular development. EUROPEAN ...
more infohttps://biblio.ugent.be/publication/7095864

COL3A1 native protein | Collagen Type III Native Protein-EAX10911.1COL3A1 native protein | Collagen Type III Native Protein-EAX10911.1

Collagen Type III Native Protein-EAX10911.1 (MBS537360) product datasheet at MyBioSource, Native Proteins. Application: User ... Fetal collagen protein; Collagen type III alpha 1 protein; Ehlers Danlos syndrome type IV; Collagen type III alpha protein; ... CO3A1: Collagen type III occurs in most soft connective tissues along with type I collagen. Defects in COL3A1 are a cause of ... Western Blot analysis using Collagen Type III protein. Lane 1: Human Collagen III. Load: 100 ng per lane. Primary antibody: ...
more infohttps://www.mybiosource.com/col3a1-native-protein/collagen-type-iii/537360

Platelet Adhesion to Multimeric and Dimeric von Willebrand Factor and to Collagen Type III Preincubated With von Willebrand...Platelet Adhesion to Multimeric and Dimeric von Willebrand Factor and to Collagen Type III Preincubated With von Willebrand...

The initial rate of adhesion was higher on vWF than on collagen type III. We conclude that adhesion to collagen type III is ... on collagen type III incubated with vWF and between 50% and 60% on vWF coated to glass. Adhesion to collagen type III in the ... collagen type III at 300 s−1 and 1500 s−1, and collagen type IV, which showed a linear phase in the first 10 minutes but ... 1 to collagen type III at 300 (▴) and 1500 (•) s−1, ECM at 1500 s−1 (▿), fibronectin at 300 s−1 (▾), and collagen type IV at ...
more infohttp://atvb.ahajournals.org/content/16/5/611

Type III collagen is important for type I collagen fibrillogenesis and for dermal and cardiovascular developmentType III collagen is important for type I collagen fibrillogenesis and for dermal and cardiovascular development

Type III collagen, a major fibrillar collagen consisting of three α1(III)-chains, is expressed in early embryos, throughout ... inproceedings{7095871, abstract = {Type III collagen, a major fibrillar collagen consisting of three α1(III)-chains, is ... Collagen type III,Transgenic Mouse Model}, language = {eng}, location = {Cleveland, OH, USA}, title = {Type III collagen is ... Type III collagen is important for type I collagen fibrillogenesis and for dermal and cardiovascular development. Sanne Dhondt ...
more infohttps://biblio.ugent.be/publication/7095871

COL3 elisa kit | Mouse Collagen Type III (COL3) ELISA Kit-EAX10911.1COL3 elisa kit | Mouse Collagen Type III (COL3) ELISA Kit-EAX10911.1

Mouse Collagen Type III (COL3) ELISA Kit-EAX10911.1 (MBS2020747) product datasheet at MyBioSource, ELISA Kits ... CO3A1: Collagen type III occurs in most soft connective tissues along with type I collagen. Defects in COL3A1 are a cause of ... This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective ... collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant), isoform CRA_b ...
more infohttps://www.mybiosource.com/col3-mouse-elisa-kits/collagen-type-iii-col3/2020747

In Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid ScarsIn Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid Scars

Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including ... In Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid Scars. ... "In Situ Cytokine Expression and Morphometric Evaluation of Total Collagen and Collagens Type I and Type III in Keloid Scars," ...
more infohttps://www.hindawi.com/journals/mi/2017/6573802/cta/

Cellularization of 3D printed Recombinant Human Collagen type III scaffolds using corneal mesenchymal stem cells | IOVS | ARVO...Cellularization of 3D printed Recombinant Human Collagen type III scaffolds using corneal mesenchymal stem cells | IOVS | ARVO...

Purpose : To investigate cellularization of 3D printed human recombinant collagen type III (RHC III) scaffolds in vitro, using ... On immunocytochemistry we observed collagen type III fibril alignment in the printed samples but not in the non-printed samples ... Cellularization of 3D printed Recombinant Human Collagen type III scaffolds using corneal mesenchymal stem cells ... Cellularization of 3D printed Recombinant Human Collagen type III scaffolds using corneal mesenchymal stem cells ...
more infohttps://iovs.arvojournals.org/article.aspx?articleid=2560824

Leicester Research Archive: LINKAGE OF A POLYMORPHIC MARKER FOR THE TYPE-III COLLAGEN GENE (COL3A1) TO ATYPICAL AUTOSOMAL...Leicester Research Archive: LINKAGE OF A POLYMORPHIC MARKER FOR THE TYPE-III COLLAGEN GENE (COL3A1) TO ATYPICAL AUTOSOMAL...

LINKAGE OF A POLYMORPHIC MARKER FOR THE TYPE-III COLLAGEN GENE (COL3A1) TO ATYPICAL AUTOSOMAL DOMINANT EHLERS-DANLOS SYNDROME ... TYPE-IV IN A LARGE BELGIAN PEDIGREE. Authors: NICHOLLS, AC. DEPAEPE, A. NARCISI, P. DALGLEISH, R. DEKEYSER, F. MATTON, M. POPE ...
more infohttps://lra.le.ac.uk/handle/2381/27116

Type III collagen Archives - CriticalCareDVMType III collagen Archives - CriticalCareDVM

Type III collagen Hip Dysplasia in Dogs & Cats - Those Hips Dont Lie!. December 11, 2017. by CriticalCareDVM ... Type III collagen ...
more infohttps://criticalcaredvm.com/tag/type-iii-collagen/

Reactome | Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1Reactome | Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1

Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 Stable Identifier ... Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Bos taurus) ... Collagen types III, IV, V, VI, VIII, IX, XVI:Integrins alpha1beta 1, alpha2beta1 [plasma membrane] (Bos taurus) ... Collagen types III, IV, V, VI, VIII, IX, XVI bind integrins alpha1beta1 and alpha2beta1 (Homo sapiens) ...
more infohttp://www.reactome.org/content/detail/R-BTA-2327695
  • Colombo M, Annoni G, Donato MF, Martines D, Zaramella MG, Bianchi PA, Piperno A, Tiribelli C: Serum type III procollagen peptide in alcoholic liver disease and idiopathic hemochromatosis: its relationship to hepatic fibrosis, activity of the disease and iron overload. (springer.com)
  • Annoni G, Colombo M, Cantaluppi MC, Khlat B, Lampertico P, Rojkind M: Serum type III prollagen peptide and laminin (Lam-P1) detect alcoholic hepatitis in chronic alcoholic abusess. (springer.com)
  • Niemela O, Risteli L, Sotaniemi A, Risteli J. Type IV collagen and laminin-related antigens in human serum in alcoholic liver disease. (springer.com)
  • Weigand K, Zaugg P-Y, Frei A, Zimmermann A: Long term follow up of the N -terminal propeptide of collagen type III in serum of patients with chronic liver disease. (springer.com)
  • Eriksson S, Zettervall O: The N -terminal propeptide of collagen type III in serum as a prognostic indicator of primary biliary cirrhosis. (springer.com)
  • This assay has high sensitivity and excellent specificity for detection of Collagen Type III (COL3). (mybiosource.com)
  • No significant cross-reactivity or interference between Collagen Type III (COL3) and analogues was observed. (mybiosource.com)
  • 3 samples with low, middle and high level Collagen Type III (COL3) were tested 20 times on one plate, respectively. (mybiosource.com)
  • 3 samples with low, middle and high level Collagen Type III (COL3) were tested on 3 different plates, 8 replicates in each plate. (mybiosource.com)
  • MBS2020747 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Collagen Type III (COL3) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • The microtiter plate provided in this kit has been pre-coated with an antibody specific to Collagen Type III (COL3). (mybiosource.com)
  • Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody specific to Collagen Type III (COL3). (mybiosource.com)
  • After TMB substrate solution is added, only those wells that contain Collagen Type III (COL3), biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. (mybiosource.com)
  • In the present study we examined platelet adhesion to purified vWF from flowing blood and compared its characteristics with those of the adhesion of platelets to collagen type III preincubated with vWF. (ahajournals.org)
  • Prolyl 3-hydroxylation of type IV collagen is required to avoid an aberrant interaction with the platelet-specific glycoprotein VI (GPVI), resulting in platelet aggregation, thrombosis of the maternal blood, and death of the embryo. (pnas.org)
  • The mechanism of the unexpectedly early lethality involves the interaction of non-3-hydroxylated embryonic type IV collagen with the maternal platelet-specific glycoprotein VI (GPVI). (pnas.org)
  • Thus, prolyl 3-hydroxylation of type IV collagen has an important function preventing maternal platelet aggregation in response to the early developing embryo. (pnas.org)
  • Brief initial vasoconstriction at the injury site favors homeostasis and late vasodilation prompts the extravasations of inflammatory cells (neutrophils and macrophages) to remove the nonfunctional cells and destroy the invading infections [ 2 , 3 ]. (hindawi.com)
  • To study the role of type III collagen in development and disease, we generated two transgenic mouse models using a BAC transgenic approach. (ugent.be)
  • Collagen chains undergo several posttranslational modifications that are indispensable for proper collagen function. (pnas.org)
  • Its digestion with cyanogen bromide yielded the small fragments α1(III)CB3B* and α1(III)CB3C, confirming T N (III) as an N-terminal helical cross-link site. (biochemj.org)
  • Horwitz, AL, Hance, AJ & Crystal, R 1977, ' Granulocyte collagenase: selective digestion of type I relative to type III collagen ', Proceedings of the National Academy of Sciences of the United States of America , vol. 74, no. 3, pp. 897-901. (elsevier.com)
  • In the present study, in order to localize type III in normal dentin, immunofluorescent and immunoelectron microscopic examinations of the molars of normal mice were carried out using affinity-purified antibodies to mouse type III and type I collagen. (elsevier.com)
  • It has been reported that, although type III collagen is present in human dentin where there is dentinogenesis imperfecta and in reparative dentin, it is absent in normal dentin. (elsevier.com)
  • So it may be easy to conclude that getting more collagen into our skin will lead to a dramatic improvement in the appearance and health of our skin. (citylaserclinic.com.au)
  • We conclude that adhesion to collagen type III is strongly but not completely determined by the adhesive properties of vWF. (ahajournals.org)
  • Prior to polymerization, the collagen monomers are prepared recombinantly whereby chemical modifications of the collagen are not needed to form such monomers. (epo.org)
  • One of these modifications, prolyl 3-hydroxylation, is accomplished by a family of prolyl 3-hydroxylases (P3H1, P3H2, and P3H3). (pnas.org)
  • Rated 5 out of 5 by Toni from Excellent Product Collagen has improved the overall feel of my joints and my hair is fuller stronger and shiny. (vitaminworld.com)
  • Studies with SpIII, an amino-terminal dimeric proteolytic fragment of vWF, show that this fragment can also support adhesion to collagen. (ahajournals.org)