Collagen Diseases: Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)Caplan Syndrome: A condition characterized by the presence of RHEUMATOID ARTHRITIS associated with a specific form of pneumoconiosis, often in coal miners and asbestos workers.Retropharyngeal Abscess: An accumulation of purulent material in the space between the PHARYNX and the CERVICAL VERTEBRAE. This usually results from SUPPURATION of retropharyngeal LYMPH NODES in patients with UPPER RESPIRATORY TRACT INFECTIONS, perforation of the pharynx, or head and neck injuries.Lung Diseases, Interstitial: A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Cineradiography: Motion picture study of successive images appearing on a fluoroscopic screen.Polymyositis: Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)Manometry: Measurement of the pressure or tension of liquids or gases with a manometer.Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.Esophageal Motility Disorders: Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).Receptors, Mitogen: Glycoprotein molecules on the surface of B- and T-lymphocytes, that react with molecules of antilymphocyte sera, lectins, and other agents which induce blast transformation of lymphocytes.Nephritis, Hereditary: A group of inherited conditions characterized initially by HEMATURIA and slowly progressing to RENAL INSUFFICIENCY. The most common form is the Alport syndrome (hereditary nephritis with HEARING LOSS) which is caused by mutations in genes for TYPE IV COLLAGEN and defective GLOMERULAR BASEMENT MEMBRANE.Collagen Type IV: A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.SwitzerlandLove: Affection; in psychiatry commonly refers to pleasure, particularly as it applies to gratifying experiences between individuals.MinnesotaPlants, Genetically Modified: PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.Malawi: A republic in southern Africa east of ZAMBIA and MOZAMBIQUE. Its capital is Lilongwe. It was formerly called Nyasaland.Creosote: A greasy substance with a smoky odor and burned taste created by high temperature treatment of BEECH and other WOOD; COAL TAR; or resin of the CREOSOTE BUSH. It contains CRESOLS and POLYCYCLIC AROMATIC HYDROCARBONS which are CARCINOGENS. It has been widely used as wood preservative and in PESTICIDES and had former use medicinally in DISINFECTANTS; LAXATIVES; and DERMATOLOGIC AGENTS.Fundulidae: Family of small, surface-dwelling fish that inhabit fresh and brackish waters, and coastal marine areas.Socialism: A system of government in which means of production and distribution of goods are controlled by the state.Infectious Disease Medicine: A branch of internal medicine concerned with the diagnosis and treatment of INFECTIOUS DISEASES.United StatesPropylaminesPeriodicals as Topic: A publication issued at stated, more or less regular, intervals.Fluvoxamine: A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.Advertising as Topic: The act or practice of calling public attention to a product, service, need, etc., especially by paid announcements in newspapers, magazines, on radio, or on television. (Random House Unabridged Dictionary, 2d ed)Travel: Aspects of health and disease related to travel.Somatotypes: Particular categories of body build, determined on the basis of certain physical characteristics. The three basic body types are ectomorph (thin physique), endomorph (rounded physique), and mesomorph (athletic physique).Blogging: Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.Weight Loss: Decrease in existing BODY WEIGHT.Diet, Reducing: A diet designed to cause an individual to lose weight.American Nurses' Association: Professional society representing the field of nursing.Credentialing: The recognition of professional or technical competence through registration, certification, licensure, admission to association membership, the award of a diploma or degree, etc.Accreditation: Certification as complying with a standard set by non-governmental organizations, applied for by institutions, programs, and facilities on a voluntary basis.Education, Medical, Continuing: Educational programs designed to inform physicians of recent advances in their field.Certification: Compliance with a set of standards defined by non-governmental organizations. Certification is applied for by individuals on a voluntary basis and represents a professional status when achieved, e.g., certification for a medical specialty.Vascular Diseases: Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.China: A country spanning from central Asia to the Pacific Ocean.Hormones: Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.Adrenocorticotropic Hormone: An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.Dermatomyositis: A subacute or chronic inflammatory disease of muscle and skin, marked by proximal muscle weakness and a characteristic skin rash. The illness occurs with approximately equal frequency in children and adults. The skin lesions usually take the form of a purplish rash (or less often an exfoliative dermatitis) involving the nose, cheeks, forehead, upper trunk, and arms. The disease is associated with a complement mediated intramuscular microangiopathy, leading to loss of capillaries, muscle ischemia, muscle-fiber necrosis, and perifascicular atrophy. The childhood form of this disease tends to evolve into a systemic vasculitis. Dermatomyositis may occur in association with malignant neoplasms. (From Adams et al., Principles of Neurology, 6th ed, pp1405-6)Knowledge Bases: Collections of facts, assumptions, beliefs, and heuristics that are used in combination with databases to achieve desired results, such as a diagnosis, an interpretation, or a solution to a problem (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed).Connective Tissue Diseases: A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Birth Certificates: Official certifications by a physician recording the individual's birth date, place of birth, parentage and other required identifying data which are filed with the local registrar of vital statistics.Arthritis, Experimental: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.Mice, Inbred DBAOrphan Nuclear Receptors: A broad category of receptor-like proteins that may play a role in transcriptional-regulation in the CELL NUCLEUS. Many of these proteins are similar in structure to known NUCLEAR RECEPTORS but appear to lack a functional ligand-binding domain, while in other cases the specific ligands have yet to be identified.ArthritisCollagen Type II: A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.Hydrocarbons, Fluorinated

Detection of anti-cytokeratin 8 antibody in the serum of patients with cryptogenic fibrosing alveolitis and pulmonary fibrosis associated with collagen vascular disorders. (1/154)

BACKGROUND: It has been suggested that the humoral immune system plays a role in the pathogenesis of cryptogenic fibrosing alveolitis (CFA). Although circulating autoantibodies to lung protein(s) have been suggested, none of the lung proteins have been characterised. The purpose of this study was to determine the antigen to which the serum from patients with pulmonary fibrosis reacted. METHODS: The anti-A549 cell antibody was characterised in a patient with CFA using Western immunoblotting and immunohistochemical staining of A549 cells. As we identified that one of the antibodies against A549 cells was anti-cytokeratin 8, the expression of mRNA of cytokeratin 8 in A549 cells was evaluated. In addition, we attempted to establish an enzyme linked immunosorbent assay to measure the levels of anti-cytokeratin 8 antibody in the serum of patients with CFA and pulmonary fibrosis associated with collagen vascular disorders (PF-CVD). RESULTS: Initially two anti-A549 cell antibodies were detected in the serum of patients with pulmonary fibrosis, one of which was characterised as anticytokeratin 8 antibody by Western immunoblotting. We were able to establish an ELISA to measure anti-cytokeratin 8 antibody and found significantly higher levels in patients with CFA and PF-CVD than in normal volunteers, patients with sarcoidosis, pneumonia, and pulmonary emphysema. CONCLUSIONS: One of the anti-A549 cell antibodies in the serum of patients with CFA was against cytokeratin 8. The serum levels of anti-cytokeratin 8 antibody were increased in patients with CFA and PF-CVD. These results suggest that anticytokeratin 8 antibody may be involved in the process of lung injury in pulmonary fibrosis.  (+info)

Collagenous gastritis and collagenous colitis: a report with sequential histological and ultrastructural findings. (2/154)

The case is reported of a young adult man with collagenous gastritis, an extremely rare disorder with only three case reports in the English literature, who subsequently presented with collagenous colitis. Sequential gastric biopsies showed a notable increase in thickness of the subepithelial collagen band. Ultrastructural study of gastric and rectal mucosa showed the characteristic subepithelial band composed of haphazardly arranged collagen fibres, prominent degranulating eosinophils, and activated pericryptal fibroblasts.  (+info)

Elevated serum and BAL cytokeratin 19 fragment in pulmonary fibrosis and acute interstitial pneumonia. (3/154)

Cytokeratin 19 fragment (CK19) levels in serum have already been documented as a useful tumour marker for lung cancer. In the present study, it was hypothesized that CK19 may be increased in the serum and epithelial lining fluid of the respiratory tract from patients with pulmonary fibrosis. CK19 was measured in the serum and bronchoalveolar lavage fluid (BALF) of patients with pulmonary fibrosis and the correlation between CK19 levels and clinical parameters evaluated. Nineteen patients diagnosed with idiopathic pulmonary fibrosis (IPF), eight with pulmonary fibrosis associated with a collagen vascular disorder (PF-CVD), seven patients with acute interstitial pneumonia (AIP), and 10 normal smokers as a control group were studied. CK19 levels in sera of patients with IPF and patients with PF-CVD were significantly increased compared to those of normal smokers. CK19 levels in sera of patients with AIP were significantly increased compared to those of other groups. CK19 values in the BALF of patients with pulmonary fibrosis were significantly elevated compared to those of normal smokers. CK19 values in sera charged according to the progression or improvement of the acute lung injury. Immunohistochemical study using pulmonary tissues obtained from patients with AIP demonstrated that the hyaline membrane and proliferating type II pneumocytes were stained by anti-human cytokeratin 19 antibody. These data demonstrated that the measurement of cytokeratin 19 fragment is a useful parameter to evaluate the activity of lung epithelial cell damage and repair.  (+info)

Collagen dysplasia (cutaneous asthenia) in a cat. (4/154)

Hereditary collagen dysplasias comprise a complex group of connective-tissue disorders that result in the reduced tensile strength of affected tissues. These processes are called cutaneous asthenia in the skin of dogs and cats. We report here the case of a crossbred male cat, aged 6 months, that presented with two skin wounds in the region of the right thorax and right iliac tuberosity. The skin of these regions and of the animal's dorsum was hyperextensible, smooth to the touch, and easily torn with minor trauma. Microscopic examination of skin samples revealed reduced dermal connective tissue consisting of shortened and fragmented collagen fibers. Normal fibers were intermingled with altered fibers. Ultrastructural changes in collagen fibers included disorientation of fibrils within the same bundle, marked spacing differences, and variation in the diameter of transverse sections. The fibrils maintained the transverse striations characteristic of normal collagen.  (+info)

Report of five novel and one recurrent COL2A1 mutations with analysis of genotype-phenotype correlation in patients with a lethal type II collagen disorder. (5/154)

Achondrogenesis II-hypochondrogenesis and severe spondyloepiphyseal dysplasia congenita (SEDC) are lethal forms of dwarfism caused by dominant mutations in the type II collagen gene (COL2A1). To identify the underlying defect in seven cases with this group of conditions, we used the combined strategy of cartilage protein analysis and COL2A1 mutation analysis. Overmodified type II collagen and the presence of type I collagen was found in the cartilage matrix of all seven cases. Five patients were heterozygous for a nucleotide change that predicted a glycine substitution in the triple helical domain (G313S, G517V, G571A, G910C, G943S). In all five cases, analysis of cartilage type II collagen suggested incorporation of the abnormal alpha1(II) chain in the extracellular collagen trimers. The G943S mutation has been reported previously in another unrelated patient with a strikingly similar phenotype, illustrating the possible specific effect of the mutation. The radiographically less severely affected patient was heterozygous for a 4 bp deletion in the splice donor site of intron 35, likely to result in aberrant splicing. One case was shown to be heterozygous for a single nucleotide change predicted to result in a T1191N substitution in the carboxy-propeptide of the proalpha1(II) collagen chain. Study of the clinical, radiographic, and morphological features of the seven cases supports evidence for a phenotypic continuum between achondrogenesis II-hypochondrogenesis and lethal SEDC and suggests a relationship between the amount of type I collagen in the cartilage and the severity of the phenotype.  (+info)

Clinical evaluation of idiopathic interstitial pneumonia and interstitial pneumonia associated with collagen vascular disease using logistic regression analysis. (6/154)

OBJECTIVE: To clarify the differences in the clinical features between idiopathic interstitial pneumonia (IIP) and interstitial pneumonia associated with collagen vascular diseases (CVD-IP). METHODS: Symptoms, radiographic findings, pulmonary function, blood chemistry data including autoantibody, and bronchoalveolar lavage fluid (BALF) findings were compared using multiple logistic regression analysis. PATIENTS: The subjects were 44 patients clinically diagnosed with IIP and 33 patients with CVD-IP. RESULTS: The clinical features related to IIP were as follows: male sex, advanced age, past history of hypertension, presence of cough, exertional dyspnea, digital clubbing, an increased level of gamma-globulin, decreased lung volume on chest X-ray, and typical type according to the criteria for IIP on chest X-ray. Increased levels of rheumatoid factor and total cell number in BALF were related to CVD-IP. CONCLUSION: These findings are considered to be useful to differentiate IIP and CVD-IP.  (+info)

Role of carbohydrate antigens sialyl Lewis (a) (CA19-9) in bronchoalveolar lavage in patients with pulmonary fibrosis. (7/154)

BACKGROUND: It has been reported that carbohydrate antigen sialyl Lewis (a) (CA19-9) levels are elevated in serum as well as in bronchoalveolar lavage fluid (BALF) of patients with pulmonary fibrosis. However, the biological significance of CA19-9 is unclear. OBJECTIVE: The purpose of the present study was to evaluate correlations between CA19-9 levels in BALF and several biochemical as well as clinical parameters in patients with pulmonary fibrosis. In addition, biological functions of CA19-9 were also examined. METHODS: We studied 24 patients with a diagnosis of pulmonary fibrosis: 16 with idiopathic pulmonary fibrosis (IPF) and 8 with pulmonary fibrosis associated with a collagen vascular disorder (PF-CVD). In BALF, carbohydrate antigens sialyl Lewis (a) (CA19-9), elastase: alpha(1)-proteinase inhibitor complex (E-PI), hepatocyte growth factor (HGF), LDH, IgG, IgA, albumin, and cell differentiation were measured. We also evaluated the effects of CA19-9 on neutrophil functions. RESULTS: CA19-9/albumin levels in BALF significantly correlated with HGF/albumin, elastase/albumin, LDH/albumin, total number of alveolar macrophages, and total number of neutrophils. Purified CA19-9 had a chemotactic activity for neutrophils. In addition, neutrophil chemotactic activity to C5a, fMLP, and interleukin 8 was significantly stimulated after incubation with purified CA19-9. Furthermore, CA19-9 increased the expression of CD15s on neutrophils. CONCLUSIONS: Our data demonstrated (i) CA19-9 in BALF correlated with other markers of inflammation in pulmonary fibrosis, and (ii) CA19-9 can modify neutrophil functions. These results suggest that CA19-9 may play a role in the process of lung injury in patients with pulmonary fibrosis.  (+info)

Alternate-day prednisone therapy and human lymphocyte subpopulations. (8/154)

The mechanisms and kinetics of the immunosuppressive effects of alternate-day prednisone were investigated in a group of patients with a variety of inflammatory diseases receiving a range of alternate-day prednisone doses from 5 to 120 mg. Total circulating lymphocyte and monocyte counts, as well as proportions of lymphocyte subpopulations defined both by surface markers and by in vitro functional capacities, were studied. At 8 a. m. of the day on prednisone, just before drug administration, lymphocyte and monocyte counts, proportions of lymphocyte subpopulations, as well as in vitro lymphocyte blastogenic responses to various mitogenic and antigenic stimuli were normal. 4 h after the administration of prednisone, there was a profound lymphocytopenia and monocytopenia, with a differential depletion of thymus-derived lymphocytes as well as various functionally defined lymphocyte subpopulations. Lymphocyte kinetic studies using a radioactive chromium-labeled autologous lymphocytes showed that the lymphocytopenia was due predominantly to a transient depletion of the recirculating portion of the intravascular lymphocytepool. All these parameters returned to normal by 8 a.m. of the following day (off prednisone) and remained normal throughout the day. This very transient lymphocytopenia and monocytopenia after prednisone, with normal cell numbers, proportions, and functions throughout the remainder of the 2-day cycle, was associated with suppression of disease activity, yet did not affect cutaneous delayed hypersensitivity in these patients nor increase the likelihood of infectious complications. This drug-associated cyclic and transient monocytopenia and selective lymphocytopenia is best explained by a redistribution of recirculating lymphocytes to other body compartments, particularly the bone marrow.  (+info)

*Bethlem myopathy

Collagen disease. COL1:. *Osteogenesis imperfecta. *Ehlers-Danlos syndrome, types 1, 2, 7 ... Diseases of myoneural junction and muscle / neuromuscular disease (G70-G73, 358-359) ... Okada M et al (2007) Primary collagen VI deficiency is the second most common congenital muscular dystrophy in Japan. Neurolog ... The onset of this disease can begin even before birth but is more commonly in childhood or later into adult life. The ...

*Dermatopathia pigmentosa reticularis

Collagen disease. COL1:. *Osteogenesis imperfecta. *Ehlers-Danlos syndrome, types 1, 2, 7 ... James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders ... Congenital malformations and deformations of integument / skin disease (Q80-Q82, 757.0-757.3) ...

*Bullous pemphigoid

Collagen disease. COL1:. *Osteogenesis imperfecta. *Ehlers-Danlos syndrome, types 1, 2, 7 ... "OMIM Entry - *113811 - COLLAGEN, TYPE XVII, ALPHA-1; COL17A1".. [permanent dead link] ... Oral lesions are present in a minority of cases.[2] The disease may be acute, but typically will wax and wane. Several other ... Bullous pemphigoid is an acute or chronic autoimmune skin disease, involving the formation of blisters, more appropriately ...

*Nonsyndromic deafness

Collagen disease. COL1:. *Osteogenesis imperfecta. *Ehlers-Danlos syndrome, types 1, 2, 7 ...

*Genetic disorder

Collagen disease. COL1:. *Osteogenesis imperfecta. *Ehlers-Danlos syndrome, types 1, 2, 7 ... sickle-cell disease, Tay-Sachs disease, Niemann-Pick disease, spinal muscular atrophy, and Roberts syndrome. Certain other ... Genetic and Rare Diseases Information Center (GARD) Office of Rare Diseases (ORD), National Institutes of Health (NIH) ... Over 6000 human diseases are caused by single-gene defects.[4] Single-gene disorders can be passed on to subsequent generations ...

*Proteinuria

Collagen vascular diseases (e.g. systemic lupus erythematosus). *Dehydration. *Glomerular diseases, such as membranous ... The 2005 UK Chronic Kidney Disease guidelines state that protein/creatinine ratio is a better test than 24-hour urinary protein ... Proteinuria secondary to autoimmune disease should be treated with steroids or steroid-sparing agent plus the use of ACE ... Chou JY, Matern D, Mansfield BC, Chen YT (2002). "Type 1 Glycogen Storage Diseases: Disorders of the Glucose-6-Phosphatase ...

*Osteogenesis imperfecta

Another suggested disease mechanism is that the stress state within collagen fibrils is altered at the locations of mutations, ... Brittle bone disease,[1] Lobstein syndrome,[2] fragilitas ossium,[1] Vrolik disease,[1] osteopsathyrosis, Porak disease, ... If the body does not destroy the improper collagen, the relationship between the collagen fibrils and hydroxyapatite crystals ... Diseases related to gastrointestinal are celiac disease, gluten sensitivity, and colitis. The acute pain experienced by ...

*Vitamin C

Until quite late in the disease the damage is reversible, as healthy collagen replaces the defective collagen with vitamin C ... Scurvy is a disease resulting from a deficiency of vitamin C, since without this vitamin, collagen made by the body is too ... Other diseases[edit]. Studies examining the effects of vitamin C intake on the risk of Alzheimer's disease have reached ... Prockop DJ, Kivirikko KI (1995). "Collagens: molecular biology, diseases, and potentials for therapy". Annual Review of ...

*Vitamin C

Until quite late in the disease the damage is reversible, as healthy collagen replaces the defective collagen with vitamin C ... Scurvy is a disease resulting from a deficiency of vitamin C, since without this vitamin, collagen made by the body is too ... Other diseases[edit]. Studies examining the effects of vitamin C intake on the risk of Alzheimer's disease have reached ... Prockop DJ, Kivirikko KI (1995). "Collagens: molecular biology, diseases, and potentials for therapy". Annual Review of ...

*Vitamin C

Until quite late in the disease the damage is reversible, as healthy collagen replaces the defective collagen with vitamin C ... Scurvy is a disease resulting from a deficiency of vitamin C, since without this vitamin, collagen made by the body is too ... Other diseases[edit]. Studies examining the effects of vitamin C intake on the risk of Alzheimer's disease have reached ... Prockop DJ, Kivirikko KI (1995). "Collagens: molecular biology, diseases, and potentials for therapy". Annual Review of ...

*Malabsorption

Systemic sclerosis and collagen vascular diseases. *Short bowel syndrome. Due to surgical structural changes *Gastrectomy; ... OGD to detect duodenal pathology and obtain D2 biopsy (for coeliac disease, tropical sprue, Whipple's disease, ... Newnham ED (2017). "Coeliac disease in the 21st century: paradigm shifts in the modern age". J Gastroenterol Hepatol (Review). ... Whipple's disease: Alcian blue with apparently eosin counterstain enlarged villus with many macrophages. ...

*维生素C - 维基百科,自由的百科全书

Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Biochem. 1995, 64: 403-34. PMID 7574488. doi: ... 膠原(Collagen)是一種蛋白質,它存在人體的結締組織、血管和骨骼的組織及牙本質細胞之間,是動物體型的基本支撐物質。所以它可以使細胞排列緊密,皮膚緊緻,骨骼牙齒堅固。當受到外傷時或是手術後它可以幫助細胞修復、促進傷口的癒合。[66][67][68] ... Prockop DJ, Kivirikko KI: Collagens: molecular

*维生素C - 维基百科,自由的百科全书

Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Biochem. 1995, 64: 403-34. PMID 7574488. doi: ... 膠原(Collagen)是一種蛋白質,它存在人體的結締組織、血管和骨骼的組織及牙本質細胞之間,是動物體型的基本支撐物質。所以它可以使細胞排列緊密,皮膚緊緻,骨骼牙齒堅固。當受到外傷時或是手術後它可以幫助細胞修復、促進傷口的癒合。[65][66][67] ... Prockop DJ, Kivirikko KI: Collagens: molecular

*Headache

Meningitis, encephalitis (inflammation of the brain tissue), Lyme disease, collagen vascular disease. A stiff neck, or ... Arteriovenous malformation, collagen vascular disease, intracranial mass lesion. Focal neurological signs indicate something is ... Neuroimaging, blood tests for collagen vascular diseases Change in personality, consciousness, or mental status. Central ... non-infectious inflammatory disease, intracranial neoplasm, epileptic seizure or other types of disorders or diseases that are ...

*Diverticulosis

Diverticular disease is more common in collagen disorders such as Ehlers Danlos Syndrome.[25] ... Cleave TL 1974 The Saccharine disease Wright Bristol *^ Painter NS (1975) Diverticular disease of the colon. Heinemann Medical ... Comparato G, Pilotto A, Franzè A, Franceschi M, Di Mario F (2007). "Diverticular disease in the elderly". Digestive Diseases. ... "Clinical manifestations and diagnosis of colonic diverticular disease". Literature review.. *^ Stefánsson T, Ekbom A, Sparèn P ...

*German Shepherd

Clinical application of D-glucosamine and scale collagen peptide on canine and feline orthopedic diseases and spondylitis ... a degenerative disease of the pancreas. It is estimated that 1% of the UK GSD population suffers from this disease.[65] ... "Von Willebrand's Disease (vWD): A Type of Hemophilia in Dogs". Drs. Foster & Smith, Inc. Retrieved 10 May 2009.. ... Additionally, German Shepherds have a higher than normal incidence of Von Willebrand disease, a common inherited bleeding ...

*German Shepherd

Clinical application of D-glucosamine and scale collagen peptide on canine and feline orthopedic diseases and spondylitis ... a degenerative disease of the pancreas. It is estimated that 1% of the UK GSD population suffers from this disease.[63] ... "Von Willebrand's Disease (vWD): A Type of Hemophilia in Dogs". Drs. Foster & Smith, Inc. Retrieved 10 May 2009.. ... Additionally, German Shepherds have a higher than normal incidence of Von Willebrand disease, a common inherited bleeding ...

*Limfocyty T regulatorowe, wolna encyklopedia

CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis. „Arthritis Rheum". 48 (5), s. 1452-1460 ... Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of ... OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset. „J Exp Med". ... CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease. „J Exp Med". 196 (3), s. 401-406, ...

*White blood cell

It rises in response to allergies, parasitic infections, collagen diseases, and disease of the spleen and central nervous ... Chronic inflammation - especially juvenile rheumatoid arthritis, rheumatoid arthritis, Still's disease, Crohn's disease, ... Infectious diseases - viral (AIDS, SARS, West Nile encephalitis, hepatitis, herpes, measles, others), bacterial (TB, typhoid, ... The number of leukocytes in the blood is often an indicator of disease, and thus the white blood cell count is an important ...

*White blood cell

It rises in response to allergies, parasitic infections, collagen diseases, and disease of the spleen and central nervous ... Chronic inflammation - especially juvenile rheumatoid arthritis, rheumatoid arthritis, Still's disease, Crohn's disease, ... Infectious diseases - viral (AIDS, SARS, West Nile encephalitis, hepatitis, herpes, measles, others), bacterial (TB, typhoid, ... The number of leukocytes in the blood is often an indicator of disease, and thus the white blood cell count is an important ...

*Relaxin - Simple English Wikipedia, the free encyclopedia

Mookerjee I. et al (2006). "Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease". ... Relaxin affects collagen metabolism, inhibiting collagen synthesis and enhancing its breakdown.[4] ...

*Robert Ira Lewy

March 1994). "Autoimmune disease and collagen dermal implants". Annals of Internal Medicine. American College of Physicians. ... "Autoimmune disease and collagen dermal implants". Annals of Internal Medicine. 120 (6): 524-525. 1994. doi:10.7326/0003-4819- ... Robert Ira Lewy (born October 16, 1943) is an American doctor who has conducted research on aspirin therapy in heart disease ... "Effect of Elevated Plasma-Free Fatty Acids on Thromboxane Release in Patients with Coronary Artery Disease". Pathophysiology of ...

*GPR56

Luo R, Jin Z, Deng Y, Strokes N, Piao X (2012). "Disease-associated mutations prevent GPR56-collagen III interaction". PLOS ONE ... Luo R, Jeong SJ, Jin Z, Strokes N, Li S, Piao X (Aug 2011). "G protein-coupled receptor 56 and collagen III, a receptor-ligand ... Jin Z, Tietjen I, Bu L, Liu-Yesucevitz L, Gaur SK, Walsh CA, Piao X (Aug 2007). "Disease-associated mutations affect GPR56 ... GPR56 was the first adhesion GPCR causally linked to a disease. Loss-of-function mutations in GPR56 cause a severe cortical ...

*Adhesion G protein-coupled receptor

Luo, R; Jin, Z; Deng, Y; Strokes, N; Piao, X (2012). "Disease-Associated Mutations Prevent GPR56-Collagen III Interaction". ... The N-terminus of GPR56 is naturally glycosylated, but this glycosylation is not necessary for Collagen III binding. Collagen ... The binding of Collagen III to GPR56 occurs on the N-terminus and has been narrowed down to a short stretch of amino acids. ... One adhesion GPCR, GPR56, has a known ligand, Collagen III, which is involved in neural migration inhibition. GPR56 has been ...

*Vitamin C

Until quite late in the disease the damage is reversible, as with vitamin C repletion, healthy collagen replaces the defective ... ISBN 0-7216-4452-X. Prockop DJ, Kivirikko KI (1995). "Collagens: molecular biology, diseases, and potentials for therapy". ... The disease was shown to be prevented by citrus fruit in an early controlled trial by a Royal Navy surgeon, James Lind, in 1747 ... The disease scurvy is caused by vitamin C deficiency and can be prevented and treated with vitamin C containing foods or ...

*Brain healing

"Collagen May Help Protect Brain Against Alzheimer's Disease", Science Daily, Dec. 10, 2008. Retrieved Oct 21st 2013.. ... A scar is formed by fibroblasts producing collagen to repair an area, which will later contract. If scars did form in the brain ... Recent studies have found collagen is extensively distributed throughout the brain and may be essential in protecting the brain ... "Distribution of collagen XVII in the human brain". Brain Res. 1158: 50-6. doi:10.1016/j.brainres.2007.04.073. PMID 17555727. " ...

*Catenin

Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR (October 2011). "A role for collagen XXIII in cancer cell ... MacDonald BT, Tamai K, He X (July 2009). "Wnt/β-catenin signaling: components, mechanisms, and diseases". Dev. Cell. 17 (1): 9- ... For instance, higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened ... levels of collagen helped facilitate adhesions and anchorage-independent cell growth and provided evidence of collagen XXIII's ...

*Couvelaire uterus

... and other collagen disease complicating pregnancy; prevention of trauma during pregnancy; mothers should also avoid smoking or ... This include proper management of hypertensive states of pregnancy; treatment of maternal diseases like diabetes mellitus, ...
Looking for Collagen-vascular disease? Find out information about Collagen-vascular disease. see autoimmune disease autoimmune disease, any of a number of abnormal conditions caused when the body produces antibodies to its own substances. Explanation of Collagen-vascular disease
China Injectable Polypeptide Hormones Corticotropin Muscle Building and Collagen Diseases, Find details about China Muscle Building, Injectable Homone from Injectable Polypeptide Hormones Corticotropin Muscle Building and Collagen Diseases - Wuhan Yuancheng Gongchuang Technology Co., Ltd.
Nonetheless, due to limited space we do ask that you invite no collagen vascular disease and pregnancy than 2 collaegn. With my 2nd youngster, I keep in mind getting that crampy feeling right after and it lasted for awhile. Now that a variety of hCG or human Chorionic Gonadotropin hormone is secreted within the physique extra meals aversions, sensitivity to odor, fatigue and constipation may be expected. As I discussed, these guys do not have these issues. Collahen involuntary leaking could occur when coughing, sneezing and collagen vascular disease and pregnancy laughing. As mentioned earlier, its not unusual for a woman to spot during her first 12 weeks of being pregnant. When crucial, I embrace further postpartum visits to insure that diseasd gets off to a terrific begin. Oxytocin itself may cause uterine contractions and thus Collagen vascular disease and pregnancy can cross-react with oxytocin receptors and trigger contractions. A prenatal multivitamin doesnt replace a healthy diet. Cite ...
Alport syndrome is a hereditary type IV collagen disease leading to progressive renal fibrosis, hearing loss and ocular changes. End stage renal failure usually develops during adolescence. COL4A3-/- mice serve as an animal model for progressive renal scarring in Alport syndrome. The present study evaluates the role of Discoidin Domain Receptor 1 (DDR1) in cell-matrix interaction involved in pathogenesis of Alport syndrome including renal inflammation and fibrosis. DDR1/COL4A3 Double-knockouts were compared to COL4A3-/- mice with 50% or 100% expression of DDR1, wildtype controls and to DDR1-/- COL4A3+/+ controls for over 6years. Double-knockouts lived 47% longer, mice with 50% DDR1 lived 29% longer and showed improved renal function (reduction in proteinuria and blood urea nitrogen) compared to animals with 100% DDR1 expression. Loss of DDR1 reduced proinflammatory, profibrotic cells via signaling of TGFbeta, CTGF, NFkappaB and IL-6 and decreased deposition of extracellular matrix. ...
title:Socio Demographic Profile and Clinical Presentation of Collagen Vascular Disease with Pulmonary Symptoms: A Descriptive Cross Sectional Study. Author:Parul Vadgama, Mehul Bhavsar, Kusum V Shah, Rajesh Solanki, Ramakant Dixit, Jignesh Vaishnani. Keywords:Collagen vascular disease, pulmonary symptoms, sceroderma, rheumatoid arthritis. Type:Original Article. Abstract:Introduction: Collagen Vascular Disease presented with varied systemic symptoms including pulmonary symptoms, commonly breathless on exertion; dry cough; cough with expectoration; chest pain; and hemoptysis. The current study was conducted to know socio demographic profile and clinical presentation of patient coming with Collagen Vascular Disease having pulmonary symptoms. Methodology: This was a descriptive cross sectional study conducted among Collagen Vascular Disease patient coming with pulmonary symptoms in outpatient department. Results: Among the 50 patients 40% patients were having SC followed by SLE (30%). Most common ...
List of causes of Collagen vascular diseases causing fever and Dry scalp in children and Food symptoms and Heart symptoms and Metacarpophalangeal joint sensitive, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
List of causes of Collagen vascular diseases causing fever and Difficulty rising from a chair and Food symptoms and Heart symptoms and Metacarpophalangeal joint sensitive, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
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Wet-lab validated real-time PCR primer assays for your biological pathway of interest. Select your gene target of interest using an interactive pathway map, and select your plate.
B. Often the diagnosis is obscured procsar of the severe degree proscar in thailand kidney destruction. Pedrotti, is associated with rheumatoid arthritis (or other collagen disease) in approximately Prтscar of patients (see section on Scleritis in Chapter 8), and approximately 45 have a known systemic condition.
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Prednisolone is used for treating allergies, arthritis, breathing problems (e.g., asthma), certain blood disorders, collagen diseases (e.g., lupus), certain eye diseases (e.g., keratitis), cancer (e.g., leukemia), endocrine problems (e.g., adrenocortical insufficiency), intestinal problems (e.g., ulcerative colitis), swelling due to certain conditions, or skin conditions (e.g., psoriasis ...
Prednisolone (Predonema). Prednisolone is used for treating allergies, arthritis, breathing problems (eg, asthma), certain blood disorders, collagen diseases (eg, lupus), certain eye diseases (eg, keratitis), cancer (eg, leukemia), endocrine problems (eg, adrenocortical insufficiency), intestinal problems (eg, ulcerative colitis), swelling due to certain conditions, or skin conditions (eg, psoriasis).. Other names for this medication. Adelcort, Adelone, Aersolin d, Ak-pred, Alertine, Alpicort, Apicort, Aprednislon, Bisuo a, Blephamide, Bronal, Capsoid, Cetapred, Chloramphecort-h, Compesolon, Cor tyzine, Corotrope, Cortan, Cortico-sol, Cortisal, Cortisol, Danalone, Decortin h, Delta-cortef, Deltacortenesol, Deltacortril, Deltahydrocortisone, Deltapred, Deltastab, Dermol, Dermosolon, Deturgylone, Dhasolone, Di-adreson-f, Dojilon, Dontisolon, Econopred, Emsolone, Encortolon, Estilsona, Fenicort, Fisiopred, Fisopred, Flo-pred, Frisolona forte, Glucortin, Gupisone, Hefasolon, Hexacorton, ...
Prednisolone (Solu-decortin). Prednisolone is used for treating allergies, arthritis, breathing problems (eg, asthma), certain blood disorders, collagen diseases (eg, lupus), certain eye diseases (eg, keratitis), cancer (eg, leukemia), endocrine problems (eg, adrenocortical insufficiency), intestinal problems (eg, ulcerative colitis), swelling due to certain conditions, or skin conditions (eg, psoriasis).. Other names for this medication. Adelcort, Adelone, Aersolin d, Ak-pred, Alertine, Alpicort, Apicort, Aprednislon, Bisuo a, Blephamide, Bronal, Capsoid, Cetapred, Chloramphecort-h, Compesolon, Cor tyzine, Corotrope, Cortan, Cortico-sol, Cortisal, Cortisol, Danalone, Decortin h, Delta-cortef, Deltacortenesol, Deltacortril, Deltahydrocortisone, Deltapred, Deltastab, Dermol, Dermosolon, Deturgylone, Dhasolone, Di-adreson-f, Dojilon, Dontisolon, Econopred, Emsolone, Encortolon, Estilsona, Fenicort, Fisiopred, Fisopred, Flo-pred, Frisolona forte, Glucortin, Gupisone, Hefasolon, Hexacorton, ...
Alarsin R.Compound is indicated in Rheumatic, Arthritic, Collagen diseases. Acute Soft Tissue Trauma. Dental Traumatic conditions. - Arthritis / Joint / Knee
Prednisolone is used for treating allergies, arthritis, breathing problems (e.g., asthma), certain blood disorders, collagen diseases (e.g., lupus), certain eye diseases (e.g., keratitis), cancer (e.g., leukemia), endocrine problems (e.g., adrenocort ...
Alport syndrome (AS) is a hereditary type IV collagen disease that leads to progressive proteinuria, renal fibrosis, and kidney failure. Depending on the mutated gene and the pattern of inheritance, there are three types ...
Hydrocortisone (Science: chemical) (11 beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione. The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Pharmacological action: steroidal anti-inflammatory agents. chemical name: Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)- ...
Identification of the molecular defect in patients with type II collagen disorders is usually a challenge because of the relatively large size and complexity of the COL2A1 gene and its main expression in cartilage. Cartilage is not easily accessible, relatively acellular, and therefore a poor source of mRNA for cDNA synthesis and analysis. Furthermore, sufficient amounts of mRNA can often not be obtained from cultured skin fibroblasts or lymphocytes owing to low basal transcription of the gene. Therefore, mutation analysis of the COL2A1 gene is often performed in the genomic DNA in a "head to tail" fashion, which is time consuming and laborious. In this study, we used the opportunity of having cartilage tissue for exploring the genetic defect in the COL2A1 gene in seven patients with a lethal type II collagen disorder. Those regions of theCOL2A1 gene in which a mutation was likely to reside, based on the overmodification pattern of the type II collagen CB peptides, were screened first with SSCP ...
Clinical. Scleroderma is a collagen-vascular disease characterized by diffuse fibrosis, degenerative changes, and vascular abnormalities in the skin, articular structures and other organs (kidneys, lung, heart, gastrointestinal and skeletal muscles). Esophageal involvement occurs in 75 to 87% of patients with scleroderma. In the esophagus, aperistalsis results from atrophy or cellular disruption of esophageal smooth muscle including the LES. These changes are primarily limited to the lower two-thirds of the esophagus because the upper third is composed of striated muscle. Patients often present with symptoms of reflux secondary to LES incompetence and dysphagia may result from abnormal motility, reflux esophagitis or peptic stricture formation. Radiological findings. Barium studies may demonstrate a normal stripping wave that clears the upper esophagus, but stops at the level of the aortic arch. This is can be attributed to the striated muscle that composes the upper third of the esophagus. In ...
Neurologic symptoms similar with those in multiple sclerosis appear in collagen-vascular diseases, Lyme disease, rare hereditary disorders, and AIDS so, although blood tests are highly recommended th...
All patients in the ONTT had blood testing to exclude collagen vascular disease (antinuclear antibody), syphilis (FTA-ABS), and a chest x-ray to detect sarcoidosis. A lumbar puncture was optional and was performed in 141 patients. Antinuclear antibody was positive in a titer 1:320 or greater in 3% of patients. Of these patients, only one developed a connective tissue disease in the first two years of follow up. FTA-ABS was positive in 1.3% of the patients, and none were judged to have syphilis. A chest x-ray did not SHOW evidence of sarcoidosis in any patients. CSF analysis never yielded unsuspected information. Based on these results, chest x-ray, blood tests, and lumbar puncture are deemed not to be necessary in evaluating patients with typical clinical features of optic neuritis ...
Evidence of areas of irregular predominately peripheral consolidation in the right lower lobe with few areas of ground glass haze and nodular shadows. There is larger shadow in the left lower lobe with peripheral consolidation with airbronchogram surrounding relatively preserved lung parenchyma. There are areas of ground glass haze. The appearance in left lower lobe is suggestive of reverse halo sign or atoll sign which is classical of cryptogenic organising pneumonia versus differentials of this appearance. The cryptogenic organizing pneumonia in the majority of cases is an idiopathic disease, while less frequently it can be associated with infectious pneumonias, airway obstruction, aspiration, drug reaction, or collagen vascular disease associated with an intake of toxic substances. The prognosis is favourable because there is a good response to steroid therapyThis needs clinical correlation and follow up. ...
Author:Parul Vadgama, Mehul Bhavsar, Kusum V Shah, Rajesh Solanki, Ramakant Dixit, Jignesh Vaishnani. Keywords:Collagen vascular disease, pulmonary symptoms, sceroderma, rheumatoid arthritis. Type:Original Article. Full PDF Abstract ...
Gammadyn Cu-Au-Ag can be used to help arthritis, chronic rheumatism, skin and collagen disorders such as psoriasis and acne, immune depletion and infectious diseases
Vascular disorders can be classified into five groups: traumatic, compressive, occlusive, tumors/malformations and vasospastic. These problems may occur more commonly in individuals with certain diseases such as diabetes, hypertension, or kidney failure, or in dialysis patients.
This volume on CVDs, renal, and respiratory disorders has particularly high value. It carries the potential to become the most effective game-changer in global health by helping all countries to combat, contain, and control the biggest killer presently prowling the globe and by enabling us to reach the 2030 goals for NCDs and health overall. As one who has witnessed the epidemic of CVDs advance menacingly across the world in the past four decades, I fervently hope that the clear and convincing messages conveyed by the extensively researched and elegantly communicated analyses in this volume will be heard, heeded, and harmonized with policy and practice in all countries ...
This is the first prospective study comparing the diagnostic accuracy of cineradiography and infused intraluminal manometry in approximately equal numbers of patients with scleroderma, polymyositis, systemic lupus erythematosus (SLE), and rheumatoid arthritis. Major criteria for inclusion of patients were as follows: scleroderma, characteristic generalized skin and visceral lesions; polymyositis, proximal muscle weakness and characteristic biopsy, rash, or electromyogram; SLE, positive antinuclear factor with several of the following-polyarthritis, butterfly rash, unexplained nephritis, or polyserositis; and rheumatoid arthritis, classical disease as diagnosed by American Rheumatism Association criteria. No patients had dysphagia at the time of evaluation. After classification, esophageal manometry and cineradiography ...
A 66-year-old male complained of thickening of the skin at the face, posterior neck and back after a febrile episode. The patient had obesity, elevated levels of HbA1C and urinary C-peptide. The seological tests for collagen diseases were negative. The serum level of vascular endothelial growth factor (VEGF) was elevated. The biopsied skin specimen revealed the thickening of the dermis by the increased proliferation of collagen fibers, thickening of collagen bundles with fenestrations and infiltration of lymphocytes. Scleredema caused by diabestes mellitus and obesity was diagnosed, accompanied with insulin resistance. The patient was initially treated with administration of prednisolone, followed with diet therapy. Scleredema ameliorated partially, however elevated level of VEGF persisted after 6 months of discharge. It is unclear whether elevated level of VEGF may be related to the pathogenesis of the disease or may be an aggravating factor ...
Connective tissue diseases by Graham R. V. Hughes; 4 editions; First published in 1977; Subjects: Collagen diseases, Connective Tissue Diseases, Connective Tissue, Diseases, Connective tissues, Internet Archive Wishlist
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ogren syndrome, Sjogren-Larsson syndrome, Skeletal dysplasia, Skeletal muscle disease, Skin collagen disease, Skin vascular disease, Sleep disorder, Sleeping seekness, Sly disease, Small bowel adenocarcinoma, Small bowel leiomyosarcoma, Small non-cleaved cell lymphoma, Smith martin dodd syndrome, Smith-Fineman-Myers syndrome, Smith-Lemli-Opitz syndrome, Smith-Magenis syndrome, Sneddon syndrome, Sneddon-Wilkinson disease, Snyder-Robinson syndrome, Soft tissue perineurioma, Soft tissue sarcomas, Sohval soffer syndrome, Solitary plasmacytoma, Solomon syndrome, Somatotroph adenoma, Sommer hines syndrome, Sommer rathbun battles syndrome, Sommer-Young-Wee-Frye syndrome, Sondheimer syndrome, Sonoda syndrome, Sorsby syndrome, Sorsbys fundus dystrophy, Sotos syndrome, Spastic paraplegia, Spellacy gibbs watts syndrome, Spherophakia-brachymorphia, Sphingolipidosis, Spina bifida, Spinal atrophy, Spirillosis, Splenic marginal zone lymphoma, Spondylarthropathy, Spondylo camptodactyly syndrome, Spondylocostal ...
Collagen diseases such as systemic lupus erythematosis, Sjogrens syndrome, scleroderma and arthritis also cause muscular pain in the head and neck. Lupus is characterized by a butterfly rash of the face, fever, rheumatoid arthitis and pleural and abdominal pain. Laboratory studies reveal a high sedimentation rate, hypochromic anemia, a positive ANA test and a false-positive VDRL. Scleroderma is characterized by gradual onset of muscle and joint pain leading to a systemic sclerosis with anorexia, dyspnea and diminished sweating. Fever, skin lesions and limited jaw and chest expansion are seen. Sjogrens syndrome is characterized by dryness of the mouth, eye and skin and oftentimes, muscle and joint pain. Rheumatoid arthritis is a chronic inflammation of the synovial membrane with pain in the muscles and joints. Numerous joints in the body are usually affected, and pain usually decreases with use. Fatigue, fever, muscle pain, night sweats and sometimes weight loss are seen. Studies show the ...
In 1875 Paget described subclavian vein thrombosis and in 1884 Schröetter proposed that subclavian vein thrombosis was the result of excessive upper extremity activity. In 1949, the surgeon Hughes coined the term "Paget-Schröetter syndrome" for patients with occlusion of the subclavian vein following overuse of the upper extremity [1, 3, 6].. DVT occurs more commonly in the veins of the pelvis or the lower extremities. In two previous reports, the incidence of upper extremity DVT has been cited as occurring in approximately 4 to 11 % of all cases of thromboembolism. DVT is classified as either primary or secondary, depending of the cause of the thrombus. Primary or idiopathic upper extremity DVT is less common than secondary, only accounting for 2 in 100,000 cases per year [7, 8]. Secondary DVT is more common and can be caused by central venous catheters, cardiac devices, neoplasias, or collagen diseases. Thrombosis of the upper extremity veins is usually related to effort in conjunction with ...
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Patients with existing blood vessel aneurysms (such as abnormalities in brain blood vessels or aortic aneurysms), atherosclerotic disease ("hardening" of the arteries, including carotid artery disease), collagen disorders, vasculitis, other underlying blood vessel abnormalities, or collagen vascular diseases (such as systemic lupus erythematosus) may be at increased risk of stroke or blood vessel dissection (525;526). Individuals with osteomyelitis (bone infection) (527), cancer involving bone (502), vertebral fractures, severe degenerative joint disease (osteoarthritis), osteoporosis, and ankylosing spondylitis may be at increased risk of fracture or spinal damage leading to nerve disorders or spinal cord damage (528-530). Prior surgery of the trachea or tracheostomy may increase the risk of tracheal rupture (531). Underlying tumors of the brain or near the spinal cord may result in adverse outcomes such as tumor rupture or delayed diagnosis (532-537). Patients with blood clotting disorders or ...
A total of 187 specimens from 142 subjects with rheumatoid arthritis, systemic lupus erythematosus, other connective tissue diseases, and controls were placed in cell culture. Specimens from 119 of the subjects grew, lasting over 2 yr in several instances. No evidence of virus infection has been found by a variety of sensitive methods, including cell fusion. Other approaches have likewise failed thus far to implicate any virus in the pathogenesis of rheumatoid arthritis.. ...
ICD M30-M36 Systemic connective tissue disorders  autoimmune disease NOS collagen (vascular) disease NOS systemic autoimmune disease systemic collagen
BIOWARFARE RESEARCH Between 1942 and the present time, biological warfare research has resulted in a more deadly and infectious form of the mycoplasma. They extracted this mycoplasma from the brucellosis bacteria, weaponized it and actually reduced the disease to a crystalline form. According to Dr. Shyh-Ching Lo, one of Americas top, top researchers, this disease agent, the mycoplasma, causes among other things, AIDS, chronic fatigue syndrome, multiple sclerosis, Wegeners disease, Parkinsons disease, Crohns colitis, Type I diabetes, and collagen-vascular diseases such as rheumatoid arthritis and Alzheimers. The mycoplasma enters into the individual cells of the body depending upon your genetic predisposition. You may develop neurological diseases if the pathogen destroys certain cells in your brain, or you may develop Crohns colitis if the pathogen invades and destroys cells in the lower bowel. Once it gets into the cell, it can lie there doing nothing sometimes for 10, 20 or 30 years, ...
The Department of Rheumatology at Columbia Asia Hospital - Whitefield, Bangalore provides diagnosis, treatment and rehabilitation for adults and children with rheumatic and related disorders. Chronic diseases like rheumatoid arthritis, osteoarthritis, gout, pseudogout and fibromyalgia are some of the diseases commonly treated. Other diseases managed are collagen vascular diseases like Systemic Lupus Erythematosus (SLE), Poly Arteritis Nodosa (PAN) and Sjögrens syndrome. Rheumatic diseases affect many parts of the body, hence multi-disciplinary care is required and treatment is customized for each patient. The consultants also use different modes of therapy like pain medications, anti-inflammatory medications, chemotherapeutic agents and intra-articular steroids.. The focus is on alleviating pain, improving quality of life and prolonging the life expectancy of patients with chronic rheumatic diseases. The department is supported by physiotherapists and occupational therapists.. ...
Have compromised ability for wound healing, such as: malnutrition, oral steroid use, history of collagen vascular disease (e.g. lupus, scleroderma, history of keloid formation (raised and thickened scars), atrophic dermatitis (extreme skin irritation or itchiness) or immunologic abnormalities such as vitiligo (white patches of skin due to loss of pigment ...
Introduction. Recent advances in therapy make early identification of patients with Pulmonary Hypertension (PH) important. The 2008 consensus statement reported an average UK treatment rate of 24.9 per million.(1). Aim. Our institution is a District General Hospital serving a population of 330,000. Our aim was to compare our treatment rate to the national average since the appointment of a physician with an interest in PH.. Method. Retrospective casenote review of patients attending our monthly PH clinic since 2006.. Results. We identified 102 Outpatient and 35 Inpatient referrals. 28 went on to receive specialist treatment for PH; mean age 66 (range 36-85); 24 female 4 male. Diagnoses: Chronic thromboembolic 10, Idiopathic 8, Collagen vascular disease 5, Congenital left to right shunt 2, COPD 2 and Portal hypertension 1. Haemodynamics (mean): Cardiac catheter: mean Pulmonary Artery Pressure (PAP) 48mmHg (n=22, range 22-78), cardiac output 4.8 (n=21, range 2.5-7.7), cardiac index 2.83 (n=22, ...
In an effort to understand the reasons behind people of any age, including children, being struck down with Rheumatoid Arthritis (RA) and other connective tissue diseases, we have delved and found some valuable and exciting conventional medical research.. The book The New Arthritis Breakthrough chronicles some 50 years of research and successful treatment of over 10,000 patients by the eminent US doctor Thomas McPherson Brown. It cites clinical trials that have repeatedly shown the link between bacteria and the inflammatory process that causes RA and other connective tissue diseases. Trial results show how these debilitating conditions are responsive to low dose antibiotic therapy. Patient reports in the book tell how antibiotic therapy has allowed them to discontinue cortisone, anti inflammatories and immuno-suppressant medications and regain a normal life after years of pain, debility, surgery, unemployment and untold difficulty.. In addition to results that are thought impossible for ...
You need to find a doctor who will listen...good luck finding one who keeps their ego in check. University Hospital ER rooms are often good places because I have found that they are so overly careful. OU and OSU in Oklahoma have great specialist. I have all the same symptoms and went years being told I had various weird but normal problems. After an ER visit because I felt I was dying, the Doc kept me for several days. During this time he discovered a 38 year old secret...I had lived with Ehlers Danlos my entire life without a diagnosis. There are six types, but in a nutshell, they are all Collagen disorders. This means the body doesnt make collagen properly. This causes tons of problems as 80 percent of the body is collagen. It is very painful, but we look normal, not only normal, but good! But we hurt, those nodes, those are common with Ehlers, we live with these problems, have surgery when we need it, but only when we need it! Look it up. If Im wrong what will it hurt? People are ignoring ...
Article from Fibromyalgia News Today (FNT) - Skin of Fibromyalgia Patients Could Provide Disease Clue Id like to share this interesting, but short article that has expanded my opinion about the link between Fibro, inflammatory/autoimmune disorders and Connective Tissue/Collagen Disorders. Via this link: Skin of Fibromyalgia Patients Could Provide Disease Clues Via: Fibromyalgia News Today.…
In Taiwan, ,2,000,000 people have a habit of chewing betel quids and an increasing number are adolescents (32) . This habit has resulted in an increase in the incidence of oral carcinoma (33) and OSF (34) . Although the etiology of OSF remains unclear, evidence has shown that it is a collagen disorder related to betel quid exposure (14, 15, 16, 17 , 22) . The obvious bimodal distribution in the betel quid exposure among OSF patients, as shown in Fig. 1⇓ , suggests individual differences in susceptibility to the development of OSF. It is essential to evaluate the OSF risk associated with polymorphisms of collagen-related genes in low- and high-exposure groups separately to examine whether the high-risk genotypes are consistent or not. Because several genes are involved in the metabolism and cross-linking of collagens, it is, therefore, important to evaluate the combined effects of multiple genes as well as the main effect of single genes. To the best of our knowledge, this is the first study to ...
Define hypercatabolism: excessive metabolic breakdown of complex substances (as protein) within the body : catabolism… - hypercatabolism in a sentence
Collagenous colitis is a type of IBD where a thick band of collagen develops under the lining of the colon. Learn about the treatment, including diet.
I have recently been diagnosed with collagenous colitis. Symptoms have been severe, chronic diarrea, bowel incontinence at night, abdominal pain, etc. I had a flexsig and a colonoscopy, both confirmi...
Sections of left pleural biopsies show fragments of pleural tissue that exhibits focal areas of dense hypocellular fibrosis consistent with a fibrous plaque. Adjoining to the plaque are hyperactive cellular areas that exhibit atypical cellular proliferation comprised of mild to moderately pleomorphic atypical cells that are arranged in a disorganized fashion with intervening dense collagen bands and scattered small mature lymphocytes. The cells are spindled to ovoid have indistinct cell borders and lightly basophilic cytoplasm. At one end of the fragment a group of cells exhibit tubular papillary configuration thus exhibiting biphasic morphology of sarcomatoid and epithelioid. A focal area of necrosis is also identified.. Immunohistochemical stains performed (in addition to those shown) show the following results:. ...
Vascular Disorders. Vascular disorders of the upper-extremity are uncommon, but ones that may have lasting implications.. Anatomy. Arteries bring oxygenated blood from the heart to the fingertips and veins return the used blood back to the heart and lungs. At the level of the wrist 2 major arteries bring blood into the hand: the radial and ulnar arteries (see Figure 1). Variations in the anatomy are common, though, which may affect the way blood flow ultimately reaches each finger.. Causes. There are many causes of vascular problems. They can be classified into 5 groups: traumatic, compressive, occlusive, tumors/malformations and vasospastic (spasm of the artery, which reduces its diameter and thus its blood flow). Vascular problems may occur more commonly in individuals with certain diseases such as diabetes, hypertension, or kidney failure, or in dialysis patients. Occupational exposure (vibrating tools, cold) can be a factor, and smoking also can aggravate and cause vascular ...
A secondary analysis of the TECOS trial affirms sitagliptin does not increase heart failure risk for patients with type 2 diabetes.
Perforating disorders are characterized by transepidermal elimination of altered keratin or dermal connective tissue material. These disorders include perforating folliculitis (as shown below), Kyrle disease, elastosis perforans serpiginosa, reactive perforating collagenosis, and acquired perforating dermatosis.
Collagen is a a fibrous protein found in skin, bone, cartilage, tendon, and other connective tissues throughout the body. Collagen is very important to the structure of the skin. In the skin it is found in the dermis layer and it is what gives the...
A middle layer of tissue in a developing animal embryo which will eventually become the muscles and other connective tissues, the blood vessels and bloo...
A type 2 excludes note represents "not included here". A type 2 excludes note indicates that the condition excluded is not part of the condition it is excluded from but a patient may have both conditions at the same time. When a type 2 excludes note appears under a code it is acceptable to use both the code (C49) and the excluded code together ...
A new approach for generating large numbers of circulatory system cells, known as vascular endothelial cells (VECs), from human amniotic-fluid-derived cells
[ after my firend had the feeding tube from her throat removed and then inserted to her stomach - aprocedure they did through the mouth then out of the stomach- she has since developed e coli.
In this case, the patient presented with anterior scleritis, anterior chamber, and vitreous cells, exudative retinal detachment over the posterior pole with multiple peripapillary and retinal dot blot and flame-shaped hemorrhages. The findings were consistent with combined anterior and posterior scleritis with an associated central retinal vein occlusion. Accordingly, we looked for evidence of underlying collagen vascular disorders and systemic vasculitides. The absence of joint pains, fever, skin rashes, evidence of chronic uveitis, and a negative serology ruled out collagen vascular disorders and systemic vasculitides. A normal systemic examination, normal peripheral blood smear, and coagulation profile made leukemia unlikely.. Differentiating orbital inflammatory syndrome from posterior scleritis is difficult as both can have orbital signs and both are exquisitely sensitive to systemic steroids. Intraocular inflammation, though, is not common in orbital inflammatory syndrome [4]. It has been ...
Nonsteroidal antiinflammatory drugs have been reported to cause reversible acute renal failure (1-4). Unlike the so-called phenacetin-induced analgesic nephropathy (5), the nephrotoxicity of nonsteroidal antiinflammatory drugs may be secondary to their prostaglandin inhibitory effect (4). We report a case of acute renal failure with nephrotic syndrome due to a hypersensitivity reaction to fenoprofen calcium (Nalfon, Dista Products Company, Indianapolis, Indiana).. A 50-year-old white woman with no history of renal or collagen-vascular disease was admitted on 5 May 1979 for treatment of morbid obesity. She had a history of severe osteoarthritis, sciatica, and surgical release of a left carpal tunnel. She ...
Introduction: Thymic malignancies represent a wide range of clinical, histological and molecular entities, with considerable heterogeneity even among tumors of the same histotype. Thymomas are rare neoplasms arising from tissue elements of the thymus and developing in the anterior mediastinum, with an annual incidence of only 0.15 cases per 100, 000 person-years. They can be associated with a variety of systemic and autoimmune disorders, such as pure red cell aplasia, pancytopenia, hypogammaglobulinemia, collagen-vascular disease, and most commonly with myasthenia gravis. Surgical resection remains the cornerstone of therapy for early-stage disease, while in advanced or recurrent forms, a multimodality approach incorporating radiation and chemotherapy is required. Platinum with anthracycline-based chemotherapy is an optimal combination for advanced thymoma. Case Report: We hereby present an interesting case of thymoma which was detected on imaging for routine health check-up and was managed successfully
The diagnosis of idiopathic pulmonary fibrosis requires the exclusion of other known causes of usual interstitial pneumonia, including use of toxic drugs, environmental exposure (asbestos), and collagen vascular disease.
H&E, 40×, 100×).. Discussion. This report describes two cases in which clinical presentation, imaging, and histopathological features are compatible with IPPFE. The recent update of the international multidisciplinary classification of the IIPs recognizes IPPFE as a specific rare IIP.6. A review of the available data shows that these two patients were older than the reported median age of 57 years at diagnosis.5 However, the absence of smoking habits is in line with the previous reports.1, 2, 5. There is little information and insufficient knowledge regarding the etiology of IPPFE and most cases are considered idiopathic, although a few cases have underlying diseases or conditions such as collagen vascular diseases, bone-marrow transplantation,4 or lung transplantation.7 Genetic predisposition is probably another factor. Frankel et al. reported two cases believed to have familial/genetic lung disease.2 Reddy et al. reported that just over half of the patients studied had recurrent lower ...
4a. Subject had planned radiation therapy at the intended expansion site while the expander is implanted.. 5. Subject has a history of failed tissue expansion or breast implantation at the intended expansion site.. 6. Subject has any existing medical condition that the doctor thinks puts the subject at an increased risk of complications (e.g., severe collagen vascular disease, poorly managed diabetes).. 7. Subject is taking any medications that the doctor thinks puts the subject at an increased risk of complications (e.g., prednisone, Coumadin).. 8. Subject is currently participating in a concurrent investigational drug or device study.. 9. Subject is a current tobacco smoker. 10. Subject is overweight (BMI , 33). 11. Subject is unwilling to comply with the air travel or altitude restriction of not , 3300 feet (1000 meters) from baseline during the time the AeroForm tissue expander is implanted.. 12. Subject has a currently implanted electronic device such as a pacemaker, defibrillator, ...
In a series of 48,005 inpatients over a 20-year period, morbilliform rash (91%) and urticaria (6%) were the most frequent skin reactions. Severe reactions are actually too rare to be detected in such cohorts. Although rare, severe cutaneous reactions to drugs have an important impact on health because of significant sequelae, including mortality. Adverse drug rashes are responsible for hospitalization, increase the duration of hospital stay, and are life threatening. Some populations are at increased risk of drug reactions, including patients with collagen vascular diseases, bone marrow graft recipients, and those with acute Epstein-Barr virus infection. The pathophysiology underlying this association is unknown, but may be related to immunocompromise or immune dysregulation. Risk of drug allergy, including severe hypersensitivity reactions, is increased with HIV infection; individuals with advanced HIV disease (e.g., CD4 T lymphocyte count ...
The background underpinning the clinical use of ultrashort echo time, SPRITE and other pulse sequences for imaging bone and other connective tissues with short T2 is reviewed. Features of the basic physics relevant to UTE imaging are described, including the consequences when the radiofrequency pulse duration is of the order of T2 so that rotation of tissue magnetization into the transverse plane is incomplete. Consequences of the broad linewidth of short T2 components are also discussed, including partial saturation by off-resonance fat suppression pulses as well as those used in multislice and multiecho imaging. The need for rapid data acquisition of the order of T2 is explained. The basic two-dimensional UTE pulse sequence with its half excitation pulse and radial imaging from the centre of k-space is described, together with options that suppress fat and/or reduce the signal from long T2 components. The basic features of SPRITE and other sequences with very short TE are described. Image
Highly pruritic, 2- to 4-mm, papular lesions with central ulceration erupted on the back of a 66-year-old woman. She had had 2 similar outbreaks in the past. The patient was taking conjugated estrogens, alprazolam, and alendronate. 1
There are only few case reports in the literature documenting outcome of pregnancy in patients with DM in contrast with those of other connective tissue diseases especially when dermatomyositis is revealed during pregnancy , most of the publications reported a poor prognosis for both the mother and the fetus , yet, in our case we confirmed the results of the rare recent cases that have tended to show a good outcome, after the treatment with glucocorticoid and immunosuppressant therapy.
Between 400,000 and 3.1 million adults have Sjögrens syndrome. This condition can affect people of any age, but symptoms usually appear between the ages of 45 and 55. It affects 10 times as many women as men. About half of patients also have rheumatoid arthritis or other connective tissue diseases, such as lupus.. In the early 1900s, Swedish physician Henrik Sjögren (SHOW-gren) first described a group of women whose chronic arthritis was accompanied by dry eyes and dry mouth. Today, rheumatologists know more about the syndrome that is named for Sjögren and-most significantly for patients-can offer advice about how to live with it.. ...
Pneumonia, Nonspecific Interstitial. In: Papadakis MA, McPhee SJ. Papadakis M.A., McPhee S.J. Eds. Maxine A. Papadakis, and Stephen J. McPhee.eds. Quick Medical Diagnosis & Treatment 2017 New York, NY: McGraw-Hill; . http://accessmedicine.mhmedical.com/content.aspx?bookid=2033§ionid=165249205. Accessed January 20, 2018 ...
Makayla Meixner February 11 2020 Collagen is the main protein in the human body, found in skin, tendons, ligaments, and other connective tissues. 28 types of collagen have been identified, with types I, II, and III being the most abundant in the human body, making up 80-90% of total collagen . Types I and III are mainly found in your skin and bones, while type II is primarily found in the joints .
Biochemistry. Extracellular proteins comprising about one third of the total protein in mammalian organism. Collagen is the main constituent of skin, tendon, bone, cartilage and all other connective tissue. The collagen helix consists of three polypeptide chains. Collagen is converted into gelatin by boiling.. ...
Purified BMP-16 proteins and processes for producing them are disclosed. DNA molecules encoding the BMP-16 proteins are also disclosed. The proteins may be used in the treatment of bone, cartilage, other connective tissue defects and disorders, including tendon, ligament and meniscus, in wound healing and related tissue repair, as well as for treatment of disorders and defects to tissues which include epidermis, nerve, muscle, including cardiac muscle, and other tissues and wounds, and organs such as liver, lung, cardiac, pancreas and kidney tissue. The proteins may also be useful for the induction of growth and/or differentiation of undifferentiated embryonic and stem cells.
Musculoskeletal Diseases, Health Challenges, and Disorders are a collection of dis-eases of the muscles and their associated ligaments and other connective tissue and of the bones and cartilage
ENAP. If ENA or any of the components of the CLS ENA test are ordered on CLS requisition, even if "Mitogen Advanced Diagnostic Lab" or "MADL" is also written on the CLS requisition, order ENAP ...
PolyGene guarantees rapid generation of genetically modified rodent models, such as mice and rats. We are specialized in genome editing via CRISPRs to generate gene knockouts and knock-ins.
This category will generally contain links to categories for medications used in the treatment of thrombosis as well as any sites that deal primarily in the treatment of the disorder.
Moyamoya Disease is a progressive disease that affects the blood vessels in the brain (cerebrovascular). It is characterized by narrowing and/or closing of the main artery to the brain (carotid).
Many things can affect the flow of blood or the vascular system, although disorders to the upper-extremities, can change health in large and long-lasting ways.
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Acroosteolysis is resorption of the distal bony phalanges. Acroosteolysis has two patterns of resorption in adults: diffuse and bandlike. The diffuse pattern of resorption has a widely diverse differential diagnosis which includes: pyknodysostosis, collagen vascular disease and vasculitis, Raynauds neuropathy, trauma, epidermolysis bullosa, psoriasis, frostbite, sarcoidosis, hypertrophic osteoarthropathy, acromegaly, and advanced leprosy. The bandlike pattern of resorption may be seen with polyvinyl chloride exposure and Hadju-Cheney syndrome. A mnemonic commonly used for acro-osteolysis is PINCHFO. Pyknodysostosis, Psoriasis, Injury (thermal burn, frostbite), Neuropathy (diabetes), Collagen vascular disease (scleroderma, Raynauds), Hyperparathyroidism, Familial (Hadju-Cheney, progeria), Occupational (polyvinyl exposure), Acroosteolysis may be associated with minimal skin changes or with ischemic skin lesions that may result in digital necrosis. Nail anatomy Yu, Joseph. Musculoskeletal ...
Other infrequently reported serious adverse events that have occurred in persons who have received BioThrax have included: cellulitis, cysts, pemphigus vulgaris, endocarditis, sepsis, angioedema and other hypersensitivity reactions, asthma, aplastic anemia, neutropenia, idiopathic thrombocytopenia purpura, lymphoma, leukemia, collagen vascular disease, systemic lupus erythematosus, multiple sclerosis, polyarteritis nodosa, inflammatory arthritis, transverse myelitis, Guillain-Barré Syndrome, immune deficiency, seizure, mental status changes, psychiatric disorders, tremors, cerebrovascular accident (CVA), facial palsy, hearing and visual disorders, aseptic meningitis, encephalitis, myocarditis, cardiomyopathy, atrial fibrillation, syncope, glomerulonephritis, renal failure, spontaneous abortion and liver abscess. Infrequent reports were also received of multisystem disorders defined as chronic symptoms involving at least two of the following three categories: fatigue, mood-cognition, ...
341 patients ⩾18 years of age (mean age 58 y, 79% men) with adequately controlled diabetes who had a stage 2 or 3 calcaneal, dorsal, or plantar foot ulcer ⩾2 cm2 in area after debridement and adequate lower extremity perfusion. Exclusion criteria included active Charcot disease, collagen vascular disease, ulcer … ...
TY - JOUR. T1 - Polyunsaturated fatty acids (PUFAs) levels in patients with cardiovascular diseases (CVDs) with and without depression. AU - Chang, Jane Pei Chen. AU - Chang, Shih Sheng. AU - Yang, Hui Ting. AU - Palani, Mahalakshmi. AU - Chen, Chun Ping. AU - Su, Kuan Pin. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Background: Cardiovascular diseases (CVDs) are commonly comorbid with depression and vice versa. Polyunsaturated fatty acids (PUFAs) have been suggested to mediate in CVDs and depression in cross-sectional and observational studies. With the patients of CVDs, we investigated the role of depression on the effect of PUFAs. Methods: Forty-four patients with CVDs were recruited and assessed with Hamilton depression rating scale (HAMD). Patients CVDs markers were measured by electrocardiogram and their red blood cell (RBC) samples were collected for PUFAs analyses. Results: The data of 44 subjects were analyzed; where 10 participants (23%) with CVDs had moderate or severe depression, defined by ...
Objective: To evaluate the efficacy and safety of long-term budesonide therapy for maintenance of clinical remission in patients with collagenous colitis.. Design: Randomised, placebo-controlled study with a 24-week, blinded follow-up period without any treatment.. Setting: Three gastroenterology clinics in Denmark.. Patients: Forty-two patients with histologically-confirmed collagenous colitis and diarrhoea (,3 stools/day).. Interventions: Patients in clinical remission after 6 weeks open-label therapy with oral budesonide (Entocort CIR capsules, 9 mg/day) received 24 weeks double-blind maintenance therapy with budesonide 6 mg/day or placebo. Thereafter, patients entered the 24-week, blinded follow-up period.. Main outcome measure: Proportion of patients in clinical remission (≤3 stools/day) at the end of maintenance therapy.. Findings: A total of 34 patients in remission at week 6 were randomised to budesonide 6 mg/day (n = 17) or placebo (n = 17). After 24 weeks maintenance treatment, ...
Neuropsychological examinations are clinically indicated and medically necessary when patients display signs and symptoms of intellectual compromise, and cognitive and/or neurobehavioral dysfunction that involve, but are not restricted to, memory deficits, language disorders, learning disorders, developmental disabilities, pervasive developmental disorders, impairment of organization and planning, and perceptual abnormalities. Neuropsychological evaluations are important in determining and outlining both subtle and more severe neurocognitive deficits among patients with cerebrovascular conditions, traumatic brain injury, epilepsy, multiple sclerosis, and HIV (AAN, Neurology, 47, 592-599), as well as hydrocephalus, neurotoxic exposure, brain tumors, and other common medical conditions such as thyroid and collagen-vascular disorders among others. Neuropsychological evaluations also provide critical adjunctive information for the diagnosis of conditions such as dementia (National Institute of ...
Kyrle disease or hyperkeratosis follicularis et parafollicularis in cutem penetrans is identified as a form of an acquired perforating disease. Other major perforating diseases are elastosis perforans serpiginosa and reactive perforating collagenosis. Recently, however, there is a controversy on categorizing Kyrle disease with perforating dermatosis or a subtype of acquired perforating collagenosis. Kyrle disease was first described by Josef Kyrle in 1916 when a diabetic woman presented generalized hyperkeratotic nodules. The disease is distinguished by large papules with central keratin plus on the skin, usually on the legs of the patient and is often in conjunction with hepatic, renal or diabetic disorders. It can affect both females and males with a 6:1 ratio. The papules usually show up on the patient with an average age of 30 years. Kyrle disease is a rare disease unless there is a high count of patients with chronic renal failure. The disease seems to be more prevalent in African ...
... is associated with chronic watery diarrhea. The colonoscopy is typically normal, but biopsies of the colon show increased numbers of chronic inflammatory cells and a pink staining stripe that looks like a collagen band in the case of collagenous colitis.
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At the first signs of the development of an anaphylactic reaction, it is necessary to stop immediately the infusion of pentoxifylline and obtain medical treatment.. In the case of application of pentoxifylline in patients with chronic heart failure, it is necessary to reach a blood circulation compensation phase firstly.. Among patients with diabetes and treated with insulin or oral hypoglycemic agents, when using high doses of pentoxifylline, the effects of these medicines on the level of sugar in the blood may be increased (see section "Interaction with other medicines and other types of interactions"). In these cases, it is advisable to reduce the dose of insulin or oral antidiabetic medicines and take special care of the patient.. In patients with systemic lupus erythematosus (SLE) or other connective tissue disease, pentoxifylline may be prescribed only after a thorough analysis of possible risks and benefits.. Since there is a risk of aplastic anemia during pentoxifylline treatment, a ...
In the present studies, aspects of some disease activity measures in rheumatoid arthritis (RA) have been investigated, including the effect of glucocorticoids on this activity. In RA, serum interleukin(IL)-6 levels were elevated and were shown to have a circadian rhythm, with peak levels in the morning, declining towards low or normal levels in the afternoon and evening. In contrast, serum levels of tumour necrosis factor(TNF) alpha were low and stable. In other connective tissue diseases, serum TNF alpha levels were elevated but without circadian variation, while IL-6 levels were low and stable. Nocturnal administration (at 2:00 a.m.) of low-dose prednisolone a few hours before the early morning peak of IL-6 was shown to be significantly more effective in reducing clinical symptoms of disease activity and serum IL-6 levels than the traditional morning administration (at 7:30 a.m.) of the same dose of prednisolone. Circulating monocytes are activated in RA, expressing receptors related to ...
... ,ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories client,medicine,medical supply,medical supplies,medical product
We are committed to a mission of providing the highest quality care for patients with arthritis and autoimmune diseases and mentoring and training medical students, residents, fellows, and young faculty. Our research mission is to better understand arthritis, autoimmune, and other connective tissue diseases in order to improve diagnosis and therapies, with the ultimate goal of finding a cure or preventing these disorders. Faculty members are involved in both clinical and laboratory research. Our research programs are centered in the clinical areas noted above and include the disciplines of clinical epidemiology, health services, and laboratory research. Our research includes collaborative efforts with other programs in the School of Medicine and the Graduate School of Public Health ...
Leukemia & Lymphoma (Contd.) Disease Cause/Risk Factors Symptoms Buzzwords Other Cervical, Supraclavicular or mediastinal nodes Lacunar Reed Sternberg Cells Hodgkins Disease Most common type; affects adolescent or young adult women EBV Variable cell composition & necrosis Collagen Bands (Nodular Sclerosis) Staging (usually I or II) determines treatment; Good prognosis CD15 & CD30 Women Variable cell composition & focal necrosis Hodgkins Disease Disordered fibrosis 2ndEBV Classic Reed Sternberg Cells most common type; men more common (Mixed Cellularity) Eosinophils, Plasma & T Cells Staging determines treatment; Guarded prognosis CD15 & CD30 1) Diffuse Fibrosis - RS Cells embedded in Fairly common - usually in older patients Poor Prognosis Hodgkins Disease fibrous stroma Often Bone Marrow Involvement (Stage III or IV) EBV Many Reed Sternberg Cells (Lymphocyte Depletion) 2) Reticular - RS Cells in sheets Poor prognosis Bone Marrow ? #s of Reed Sternberg Cells Usually not a true Hodgkins ...
Aim.To determine the prevalence of cardiovascular diseases (CVDs) and cardiovascular mortality in patients with chronic obstructive pulmonary disease (COPD).. Material.COPD patients (n=3571) were checked if they had CVDs (CAD - coronary artery disease, HF - heart failure, AH - arterial hypertension, CCP - chronic cor pulmonale, CVD - cerebrovascular disease) and mortality. Of these, 2642 (74%) were male and 929 (26%) women, aged 65.4 (SD ± 9.7), and FEV1 = 49.8 (SD ± 18.9)% pred.The risk for CVDs (OR - Add Ratio) was compared with that of 150 controls.. Results. Among COPD patients 84.5% had CVDs: 59% (GOLD I), 74% (GOLD II), 86% (GOLD III) and 99% (GOLD IV) (r=0.35, p=0.0001); OR=1.96. Correlation was found between age and prevalence of CVDs: 48.7% (40-49yrs), 71.6% (50-59yrs), 85% (60-69yrs) and 96.9% (, 70yrs) (r=0.38, p=0.0001).. Patients with COPD had a higher prevalence of CVDs and cardiovascular risk: CAD (66%; OR = 1.8), HF (74%; OR = 1.9), AH (45%; OR = 1.2), CCP (46%; OR = 3.8) and ...
Saya benci waktu pagi. Bile sampai je kat opis semua org jalan super fast. tak sempat nak berangan taw. i need to take 2 lift to reach my opis. complicated. sgt happy coz masuk2 keje and check schedule of the day NONE. langsung takde meeting, appointment, discussion dan sewaktu dgnnye. seee...im grinning wider and wider now. relaks a bit. just the email yg dh reach limit since semlm tak keje. phewww.... Yesterday niat dihati nak survey Collagen. plan to consume collagen few months before wedding. Ever heard of collagen before? thsi stuff is quite famous tapi utk org2 kuno macam saya ni baru la mendapat kesedaran sivik utk mendalaminye and the effectiveness of this collagen. Collagen is the component in our body that basically helps hold us together. It is present in our skin, bones, cartilage and other connective tissues and is crucial to maintaining a youthful body and appearance. The reason that many of us feel we are rapidly falling downhill when it comes to the aging process is because we ...
Tendons and other connective tissue are often thought of as non-trainable, but more and more research is showing that they are more responsive to load than we thought. Professor Keith Baar is a leading researcher on the topic and joins this weeks GAINcast to talk about how connective tissue works together with muscles and bones to produce movement. We also dive into how connective tissue can be trained, as well as several other topics he has been researching ...
A molecule that contains both protein and glycosaminoglycans, which are a type of polysaccharide. Proteoglycans are found in cartilage and other connective tissues ...
... : The Linking Pathogen in Neurosystemic Diseases Several strains of mycoplasma have been engineered to be more dangerous. They are now blamed for Adult-onset Asthma, AIDS, CFS, MS, RA and other diseases. Dr Maurice Hilleman, chief virologist for the pharmaceutical company Merck Sharp & Dohme, has stated that this disease agent is carried by everybody in North America and possibly most people throughout the world.. Pathogenic MYCOPLASMA Patent U.S. Patent #5,242,820 states that Mycoplasma fermentans incognitus is implicated in:. AIDS, Chronic Fatigue Syndrome. Alzheimers Disease. Wegeners Disease. Sarcoidosis. respiratory distress syndrome (asthma). Kikuchis disease. autoimmune diseases such as Collagen Vascular Disease and Lupus. M. fermentans incognitus may be either a causative agent or a key co-factor in these diseases. Particulate Matter and Mycoplasma Stress Interactions ...
Achondrogenesis is a severe skeletal dysplasia that is invariably lethal before or after birth. Achondrogenesis type IA (ACG1A; MIM 200600) and IB (ACG1B; MIM 600972) are autosomal recessive disorders caused by mutations in the TRIP11 and SLC26A2 genes, respectively. Achondrogenesis type II (ACG2; MIM 200610) is an autosomal dominant disorder caused by mutations in the COL2A1 gene. All types are clinically overlapping and are mainly characterized by short-limbed dwarfism, short ribs, small chest, absent or minimally ossified vertebral bodies, and hydrops fetalis.. Copy number variation (CNV) analysis of the Achondrogenesis genes is also offered as a panel. Additionally, CTGT offers a comprehensive test (both NGS and CNV panels) for these genes. Panel genes are also offered as individual sequencing and deletion/duplication tests unless otherwise indicated.. Read less ...
Rheumatoid arthritis is a connective tissue disorder which manifests in various clinical presentations. Before anything is discussed about it, we ought to know what a connective tissue disorder is
Collagenous gastritis is an extremely rare disorder and little is known about its aetiopathogenesis and natural history. The three previous reports described this condition (a) in isolation,1(b) with synchronous lymphocytic colitis,2 and (c) with synchronous collagenous colitis and collagenous duodenitis.3 This is the first report of a case presenting initially with collagenous gastritis and subsequently with features of collagenous colitis.. The clinical, endoscopic, and histological features in our case are similar to those described by Colletti and Trainer.1 Both patients were young and presented with epigastric pain and gastrointestinal bleeding. Our patient, however, presented with chronic anaemia which did not improve with H2 receptor blockers, antihelminthic treatment, and iron supplements, suggesting chronic blood loss. This was unlike the acute upper gastrointestinal bleeding seen in the patient described by Colletti and Trainer. Our endoscopic finding of gastric nodularity had been ...
Looking for online definition of connective tissue diseases in the Medical Dictionary? connective tissue diseases explanation free. What is connective tissue diseases? Meaning of connective tissue diseases medical term. What does connective tissue diseases mean?
Definition of mixed connective tissue diseases in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is mixed connective tissue diseases? Meaning of mixed connective tissue diseases as a legal term. What does mixed connective tissue diseases mean in law?

Medical Dictionary Definitions A - Z List - «B»Medical Dictionary Definitions A - Z List - «B»

Popular Diseases & Conditions. Abdominal MRI scan Alcohol and pregnancy Duchenne muscular dystrophy Gastrostomy feeding tube ... The basement membrane is made up of proteins held together by type IV collagen. The epithelial cells are anchored with ...
more infohttp://drugline.org/medic/letter/B/page/8

Collagen vascular disease: MedlinePlus Medical EncyclopediaCollagen vascular disease: MedlinePlus Medical Encyclopedia

Some of these diseases are similar to each other. They may involve arthritis and inflammation of ... In a class of diseases known as autoimmune disorders, the bodys immune system attacks its own tissues. ... People who developed these disorders were previously said to have "connective tissue" or "collagen vascular" disease. We now ... In a class of diseases known as autoimmune disorders, the bodys immune system attacks its own tissues. Some of these diseases ...
more infohttps://medlineplus.gov/ency/article/001223.htm

Collagen in colon disease | SpringerLinkCollagen in colon disease | SpringerLink

The pathophysiology of wound healing in the bowel wall suggests that collagen and matrix metalloproteinases (MMPs) have an ... Extracellular matrix Bowel disease MMPs Anastomotic leakage Diverticular diseases Crohns disease This is a preview of ... Seromarkers of collagen I and III metabolism in active Crohns disease. Relation to disease activity and response to therapy. ... Alexander AC, Irving MH (1990) Accumulation and pepsin solubility of collagens in the bowel of patients with Crohns disease. ...
more infohttps://link.springer.com/article/10.1007%2Fs10029-006-0149-4

What is the prevalence of collagen-vascular diseases in alopecia areata?What is the prevalence of collagen-vascular diseases in alopecia areata?

Collagen-vascular diseases have been found in 0.6-2% of patients with alopecia areata, while the incidence in control subjects ... Drugs & Diseases , Dermatology , Alopecia Areata Q&A What is the prevalence of collagen-vascular diseases in alopecia areata?. ... What is the prevalence of collagen-vascular diseases in alopecia areata?) and What is the prevalence of collagen-vascular ... Collagen-vascular diseases have been found in 0.6-2% of patients with alopecia areata, while the incidence in control subjects ...
more infohttps://www.medscape.com/answers/1069931-62694/what-is-the-prevalence-of-collagen-vascular-diseases-in-alopecia-areata

Collagen Vascular Disease: Causes, Symptoms & TreatmentsCollagen Vascular Disease: Causes, Symptoms & Treatments

Lupus, rheumatoid arthritis, and scleroderma are all types of collagen vascular disease. ... Collagen vascular disease. "Collagen vascular disease" is the name of a group of diseases that affect your connective tissue. ... Causes of collagen vascular disease. Collagen vascular disease is an autoimmune disease. This means that your immune system ... Collagen vascular disease is sometimes also called connective tissue disease. Collagen vascular diseases can be heritable ( ...
more infohttps://www.healthline.com/health/collagen-vascular-disease

Search of: Collagen Disease | Esomeprazole - List Results - ClinicalTrials.govSearch of: 'Collagen Disease' | 'Esomeprazole' - List Results - ClinicalTrials.gov

Pharmacokinetics (PK) of Esomeprazole: Area Under the Concentration-Time Curve From the Time of Dosing to the Last Measurable Concentration (AUC[0-t ...
more infohttps://clinicaltrials.gov/ct2/results?cond=%22Collagen+Disease%22&intr=%22Esomeprazole%22

Collagen peptides giving me herx? - Lyme DiseaseCollagen peptides giving me herx? - Lyme Disease

Allergies & Asthma Alzheimers Disease Anxiety & Panic Disorders Arthritis Breast Cancer Chronic Fatigue Crohns Disease Cystic ... Lyme Disease Multiple Sclerosis Parkinsons Disease Prostate Cancer ... I cant take collagen. It brings on shingles for me. Same with bone broth. High in arginine. Arginine is in Buhners bart ... Anxiety & Panic Disorders Bipolar Disorder Breast Cancer Chronic Pain Crohns Disease Depression Diabetes Fibromyalgia GERD & ...
more infohttps://www.healingwell.com/community/default.aspx?f=30&m=4035777

Collagen disease - WikipediaCollagen disease - Wikipedia

Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus ... The term "collagen disease" was coined by Dr. Alvin F. Coburn in 1932, on his quest to discover streptococcal infection as the ... ISBN 0-8027-0449-2. Collagen disease entry in the public domain NCI Dictionary of Cancer Terms This article incorporates public ... but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the ...
more infohttps://en.wikipedia.org/wiki/Collagen_disease

JCI -
A collagen VI-dependent pathogenic mechanism for Hirschsprungs diseaseJCI - A collagen VI-dependent pathogenic mechanism for Hirschsprung's disease

Increased collagen VI levels during development mainly result in slower migration of eNCCs. This appears to be due to the fact ... Hirschsprungs disease (HSCR) is a severe congenital anomaly of the enteric nervous system (ENS) characterized by functional ... expression that increases total collagen VI protein levels in the extracellular matrix (ECM) surrounding both the developing ... that contains an untargeted transgenic insertion upstream of the collagen-6α4 (. Col6a4. ) gene. This insertion induces eNCC- ...
more infohttps://www.jci.org/articles/view/83178/figure/1

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. | PNASAnti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. | PNAS

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.. R O Williams, M Feldmann, and R N ... Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. ... Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. ... Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. ...
more infohttps://www.pnas.org/content/89/20/9784?ijkey=b713f199634ac6787a4313a62499d9344148b634&keytype2=tf_ipsecsha

Aloe vera/collagen/lidocaine/sodium hyaluronate topical Disease Interactions - Drugs.comAloe vera/collagen/lidocaine/sodium hyaluronate topical Disease Interactions - Drugs.com

Comprehensive disease interaction information for aloe vera/collagen/lidocaine/sodium hyaluronate topical. Includes Lidocaine ... There are 5 disease interactions with aloe vera / collagen / lidocaine / sodium hyaluronate topical:. Major Lidocaine (Includes ... Aloe vera / collagen / lidocaine / sodium hyaluronate topical Rating. No Reviews - Be the first! ... aloe vera / collagen / lidocaine / sodium hyaluronate topical drug Interactions. There are 6 drug interactions with aloe vera ...
more infohttps://www.drugs.com/disease-interactions/aloe-vera-collagen-lidocaine-sodium-hyaluronate-topical.html

Interstitial Lung Disease Associated With Collagen-Vascular Disease: Background, Pathophysiology, EtiologyInterstitial Lung Disease Associated With Collagen-Vascular Disease: Background, Pathophysiology, Etiology

Collagen-vascular diseases (CVDs) are a heterogeneous group of autoimmune disorders characterized by the presence of ... Interstitial Lung Disease Associated With Collagen-Vascular Disease) and Interstitial Lung Disease Associated With Collagen- ... Interstitial Lung Disease Associated With Collagen-Vascular Disease * Sections Interstitial Lung Disease Associated With ... Collagen vascular disease-related lung disease: high-resolution computed tomography findings based on the pathologic ...
more infohttps://emedicine.medscape.com/article/1343513-overview

Collagen Archives | Cure DiseaseCollagen Archives | Cure Disease

Tag: Collagen. Supplements Best Collagen Supplements - January, 2020 Reviews & Buyers Guide. That decrease can lead to ...
more infohttps://www.curedisease.com/tag/collagen/

Recent Articles | Collagen And Disease/Medicine | The Scientist Magazine®Recent Articles | Collagen And Disease/Medicine | The Scientist Magazine®

A combination gene-and-cell therapy has given a boy with a grievous skin disease a new lease on life, and has resolved a ... Boosting levels of a the immunosuppressive protein PD-L1 in blood stem cells halts diabetes in a mouse model of the disease. ... Infectious protein aggregates from the skin of human patients can cause disease in mice. ... tags: collagen x disease/medicine x The Scientist. » collagen and disease/medicine ...
more infohttps://www.the-scientist.com/?articles.list/categoryNo/2625/category/The-Scientist/tagNo/3480,6/tags/collagen,disease-medicine/

Collagen vascular disease dictionary definition | collagen vascular disease definedCollagen vascular disease dictionary definition | collagen vascular disease defined

... often autoimmune diseases affecting connective tissue, including lupus erythematosus, rheumatoid arthritis, and scleroderma. ... often autoimmune diseases affecting connective tissue, including lupus erythematosus, rheumatoid arthritis, and scleroderma. ... collagen vascular disease definition: nounAny of a group of inflammatory, ... collagen vascular disease definition: nounAny of a group of inflammatory, ...
more infohttp://www.yourdictionary.com/collagen-vascular-disease

JCI -
Hirschsprungs disease, Down syndrome, and missing heritability: too much collagen slows migrationJCI - Hirschsprung's disease, Down syndrome, and missing heritability: too much collagen slows migration

Soret and colleagues identify a new mechanism that causes HSCR-like disease in mice and involves deposition of excess collagen ... Hirschsprungs disease, Down syndrome, and missing heritability: too much collagen slows migration. ... Hirschsprungs disease, Down syndrome, and missing heritability: too much collagen slows migration. ... Hirschsprungs disease (HSCR) causes functional intestinal obstruction due to the absence of the enteric nervous system (ENS) ...
more infohttps://www.jci.org/articles/view/85003/pdf

Collagen disease | definition of collagen disease by Medical dictionaryCollagen disease | definition of collagen disease by Medical dictionary

... collagen disease explanation free. What is collagen disease? Meaning of collagen disease medical term. What does collagen ... Looking for online definition of collagen disease in the Medical Dictionary? ... Related to collagen disease: Scleroderma, Connective tissue disorder. col·la·gen dis·ease. , collagen-vascular disease. a group ... collagen diseases like lupus, dermatologic diseases, ophthalmic diseases, respiratory diseases, gastrointestinal diseases, ...
more infohttp://medical-dictionary.thefreedictionary.com/collagen+disease

Engineering Biointerfaces To Reveal Collagen IV Disease Mechanisms | 71654Engineering Biointerfaces To Reveal Collagen IV Disease Mechanisms | 71654

... of collagen IV mutations disease remain poorly characterized. To provide novel insights into collagen diseases mechanisms, this ... Mutations in the BMs major component collagen IV can cause eye and kidney defects and cerebrovascular disease including ... Engineering biointerfaces to reveal collagen IV disease mechanisms. 8th International Conference on Tissue Science and ... fibronectin and collagen IV. This has enabled to address the hypothesis that biomaterials can alter collagen mutant cells ...
more infohttps://www.omicsonline.org/proceedings/engineering-biointerfaces-to-reveal-collagen-iv-disease-mechanisms-71654.html

Intex Natural Products Conducts Systematic Review: Studies Prove Collagen Effective in Reducing Chronic Back Pain and...Intex Natural Products Conducts Systematic Review: Studies Prove Collagen Effective in Reducing Chronic Back Pain and...

Most musculoskeletal degenerative diseases, including osteoarthritis, spinal stenosis, and degenerative disk disease, involve ... Collagen: Why All the Fuss?. Collagen is a family of highly fibrous proteins found in all animals, and is the most abundant ... The main types of collagen in these tissues are Types I, II, III, V, and IX. Type I is the principle collagen found in skin and ... We were fascinated by collagen and we conducted thorough studies to ensure we had the proper dosage and type of collagen ...
more infohttp://www.prweb.com/releases/flobax/chronicbackpain/prweb8095796.htm

Could Cancer Really be a Collagen Disease? | GreenMedInfo | Blog EntryCould Cancer Really be a Collagen Disease? | GreenMedInfo | Blog Entry

Pauling and Matthias Rath, MD, later completed a 15-year study in which they demonstrated that cancer is a collagen disease ... CANCER-PROOF YOUR COLLAGEN. Collagen is composed of several key nutrients that are only available through diet - your body ... Heres what I did to strengthen my collagen:. • Boost Collagen with Key Supporting Nutrients. The original formula from Pauling ... Modern researchers have continued to look further into the collagen connection to cancer and found that while healthy collagen ...
more infohttp://www.greenmedinfo.com/blog/could-cancer-really-be-collagen-disease

Disease-Associated Mutations Prevent GPR56-Collagen III InteractionDisease-Associated Mutations Prevent GPR56-Collagen III Interaction

... PLoS ONE 7(1): e29818. ... Our study reveals that although glycosylation is not required for ligand binding, each of the four disease-associated mutations ... This domain contains four disease-associated mutations and two N-glycosylation sites. ... we have recently demonstrated that collagen III is the ligand of GPR56 in the developing brain. In this report, we discover a ...
more infohttps://dash.harvard.edu/handle/1/8699137

Collagen Vascular Disease, Pleural | Springer for Research & DevelopmentCollagen Vascular Disease, Pleural | Springer for Research & Development

Rheumatic pleuritis Collagen vascular diseases are a complex group of systemic inflammatory diseases generally considered ... Collagen vascular diseases are a complex group of systemic inflammatory diseases generally considered autoimmune in etiology. ... McQuitty E., Allen T.C. (2018) Collagen Vascular Disease, Pleural. In: Allen T.C., Suster S. (eds) Pathology of the Pleura and ... Many collagen vascular diseases involve pulmonary parenchyma with resulting significant morbidity (hyperlink). They also ...
more infohttps://rd.springer.com/referenceworkentry/10.1007/978-3-319-66796-6_351

Collagen Vascular Disease, Pleural | Springer for Research & DevelopmentCollagen Vascular Disease, Pleural | Springer for Research & Development

Rheumatic pleuritis Collagen vascular diseases are a complex group of systemic inflammatory diseases generally considered ... Collagen vascular diseases are a complex group of systemic inflammatory diseases generally considered autoimmune in etiology. ... McQuitty E., Allen T.C. (2018) Collagen Vascular Disease, Pleural. In: Allen T.C., Suster S. (eds) Pathology of the Pleura and ... Many collagen vascular diseases involve pulmonary parenchyma with resulting significant morbidity (hyperlink). They also ...
more infohttps://rd.springer.com/referenceworkentry/10.1007%2F978-3-319-66796-6_351

Esophageal Function in Collagen Disease. | Annals of Internal Medicine | American College of PhysiciansEsophageal Function in Collagen Disease. | Annals of Internal Medicine | American College of Physicians

Esophageal Function in Collagen Disease. R. Turner, M.D.; W. Lipshutz, M.D.; A. Tuck, M.D.; W. Miller, M.D.; R. Schumacher, M.D ... Turner R, Lipshutz W, Tuck A, Miller W, Schumacher R, Cohen S. Esophageal Function in Collagen Disease.. Ann Intern Med. 1971; ... classical disease as diagnosed by American Rheumatism Association criteria. No patients had dysphagia at the time of evaluation ...
more infohttp://annals.org/aim/article-abstract/685510/esophageal-function-collagen-disease

A8.9 Neutralisation of miR-155 ameliorates collagen-induced arthritis | Annals of the Rheumatic DiseasesA8.9 Neutralisation of miR-155 ameliorates collagen-induced arthritis | Annals of the Rheumatic Diseases

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more infohttps://ard.bmj.com/content/74/Suppl_1/A84.2.citation-tools
  • Gram-for-gram, some types of collagen fibrils are stronger than steel. (greenmedinfo.com)
  • Research shows that it is more effective to supplement with the nutrients your body uses to make the types of collagen it needs and to eliminate those habits that help to deplete vitamin C and weaken the collagen matrix. (greenmedinfo.com)
  • In this issue of the JCI , Soret and colleagues identify a new mechanism that causes HSCR-like disease in mice and involves deposition of excess collagen VI in the intestine by migrating ENS precursors as they colonize fetal bowel. (jci.org)
  • If it happens that you do have Peyronie's disease you will want to begin a conservative course of care to help your body heal and repair the infiltration of excess collagen in the deep tissue of the shaft. (peyronies-disease-help.com)
  • Stallmach A, Schuppan D, Riese HH, Metthes H, Riecken EO (1992) Increased collagen type III synthesis by fibroblasts isolated from strictures of patients with Crohn's disease. (springer.com)
  • In primary demyelinating disease, MS, a renewed interest in the role of humoral immunity in the pathophysiology has been investigated because oligoclonalIgG band in the CSF and increased intrathecalIgG synthesis are used as an auxiliary diagnosis measure. (biomedcentral.com)
  • IL-13 Promotes Collagen Accumulation in Crohn s Disease Fibrosis by Down-Regulation of Fibroblast MMP Synthesis: A Role for Innate Lymphoid Cells? (crohnsforum.com)
  • In fCD muscle extracts, collagen synthesis was significantly increased compared to other groups, but MMP-2 was not co-ordinately increased. (crohnsforum.com)
  • Ehlers-Danlos syndrome - defect in the synthesis of collagen (Type I or III) causes progressive deterioration of collagens, with different EDS types affecting different sites in the body, such as joints, heart valves, organ walls, arterial walls. (wikipedia.org)
  • Collagen vascular diseases can be heritable (inherited from one's parents) or autoimmune (resulting from activity of the body's immune system against itself). (healthline.com)
  • With age, the body's inability to produce and regenerate these collagen matrices leads to wear and tear on the joints, causing pain, stiffness, decreased function, and sometimes even deformities due to joint misalignments. (prweb.com)
  • Even so, there are enzymes in cancer cells that can eat through your body's collagen . (greenmedinfo.com)
  • Collagen Fibre Disease Rhinoplasty Surgery mass say it blocks your body's power to and your skin still itchy Avoid skin damage and ignore skincare products that contain alcohol. (phorbitech.eu)
  • Anti-TNF administered prior to disease onset significantly reduced paw swelling and histological severity of arthritis without reducing the incidence of arthritis or the level of circulating anti-type II collagen IgG. (pnas.org)
  • Diagnosis depends on typical clinical features, muscle biopsy (for suspected Ullrich CMD) or skin biopsy (for suspected Bethlem myopathy) and genetic testing that shows mutations in the collagen VI genes. (cdc.gov)
  • The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of Collagen genes. (patentsencyclopedia.com)
  • Consequently, matrix degradation is down-regulated and this leads to excessive collagen deposition. (crohnsforum.com)
  • Mutations in the BMs major component collagen IV can cause eye and kidney defects and cerebrovascular disease including intracerebral hemorrhages (ICH). (omicsonline.org)
  • While ER-retention of collagen IV and ER-stress are associated with hemorrhagic stroke caused by a COL4A2 mutation, the mechanism(s) of collagen IV mutations disease remain poorly characterized. (omicsonline.org)
  • Collectively, these data provide a beginning to our understanding of how these mutations affect cell function/behavior and also increase our knowledge of the disease mechanisms. (omicsonline.org)
  • The data can in the long term be used to the development of new therapeutic approaches for ICH and pathologies due to collagen IV mutations. (omicsonline.org)
  • This domain contains four disease-associated mutations and two N-glycosylation sites. (harvard.edu)
  • Our study reveals that although glycosylation is not required for ligand binding, each of the four disease-associated mutations completely abolish the ligand binding ability of GPR56. (harvard.edu)
  • Using recombinant human C7 (rhC7) purified from human dermal fibroblasts (FB-rhC7), we showed previously that intravenously injected rhC7 distributed to engrafted RDEB skin, incorporated into its dermal-epidermal junction (DEJ), and reversed the RDEB disease phenotype. (nih.gov)
  • TN3-19.12, a hamster IgG1 monoclonal antibody to murine TNF-alpha/beta, was injected i.p. into mice either before the onset of arthritis or after the establishment of clinical disease. (pnas.org)
  • Mice who ate radioactive collagen hydrolysate showed increased radioactivity in the knee joint. (marksdailyapple.com)
  • Methods Collagen-induced arthritis (CIA) was induced in mice lacking Flt3L (Flt3L -/- ) and WT littermates (C57/BL6 background, 9-10 weeks old). (bmj.com)
  • This analysis revealed the striking increase in collagen VI in the brains of mice that model AD. (vitalitynow.org)
  • An immunosuppressive role for B cells during CIA was further described in studies where the CD21hi CD23+ IgM+ transitional 2 marginal zone precursor (T2-MZP) cell population was isolated and transferred to collagen-immunized DBA/1 mice (54). (igf-1r.com)
  • The B10 cell-enriched B cells were then transferred to collagen-immunized DBA/1 mice where they delayed the onset of arthritis and specifically downregulated Th17 responses. (igf-1r.com)
  • These experiments revealed found that when the proteins associated with Alzhiemer's were added to neurons grown in culture it increased the expression of collagen VI. (vitalitynow.org)
  • Some such diseases are hereditary, while others may typically affect a certain breed of dogs, and then there are some that may simply be caused by a lack of certain nutrients that a dog may need more of. (k9collagen.com)
  • Our body produces less and less collagen as we age - this is part of our normal ageing process. (deepmarine.com)
  • Importantly, for a majority of patients in a HSCR cohort, the myenteric ganglia from the ganglionated region are also specifically surrounded by abundant collagen VI microfibrils, an outcome accentuated by Down syndrome. (jci.org)
  • This is the most abundant collagen of the human body. (news-medical.net)
  • We have reported that col(V)-induced tolerance down regulates IL-17 and prevents immune-mediated lung diseases. (iupui.edu)
  • Glucocorticoids remain to be among the most important and most frequently used anti-inflammatory and immunosuppressive or immune-modulatory acting drugs to treat rheumatic (and other) diseases. (clinicaltrials.gov)
  • Despite evidence that B cells are inflammatory mediators of autoimmunity during CIA, some B cells subsets have also been shown to negatively regulate antigen-specific immune responses during arthritic disease. (igf-1r.com)
  • To achieve this, a high-resolution microscopy AFM was employed, biochemical analysis of COL4A2+/G702D cells cultured on synthetic polymers coated with ECM proteins, namely laminin, fibronectin and collagen IV. (omicsonline.org)
  • Advanced Glycation End Products (AGEs) are formed when sugars in the blood first attach to proteins, then target collagen, making the collagen brittle and weak. (greenmedinfo.com)
  • Dr. Mucke's team took it one step further and examined the direct interactions of collagen VI with theAlzheimer's proteins. (vitalitynow.org)
  • Normally small poisonous assemblies of these proteins, called oligomers, bind strongly to vulnerable neurons in the brain, but in the presence of collagen VI, this binding was blocked. (vitalitynow.org)
  • Parra-Blanco A (2006) Colonic diverticular disease: pathophysiology and clinical picture. (springer.com)
  • More relevant to human disease was the capacity of the antibody to reduce the clinical score, paw swelling, and the histological severity of disease even when injected after the onset of clinical arthritis. (pnas.org)
  • A report indicates that adverse events such as the demyelinating lesion in the brain, optic neuritis, and neuropathy occurred after treatment with anti-TNF alpha therapy in collagen disease, and TNF antagonizing therapy showed worsening in a clinical trial with MS. Pathogenesis of these events such as primary or secondary demyelination are still in enigma. (biomedcentral.com)
  • 8 Other results obtained with this model correlate well with clinical findings in humans, eg, in patients with factor VIII deficiency and various subtypes of von Willebrand's disease. (ahajournals.org)
  • Clinique Even Better Clinical Dark Spot Corrector 1 oz / 30 ml : Facial Spot Treatments : Beauty Aqua Skin Forte Collagen. (phorbitech.eu)
  • In one study , rats with osteoporosis ate collagen hydrolysate that scientists had marked with a radioactive signature to allow them to track its course through the body. (marksdailyapple.com)
  • A pharmacokinetic, pharmacodynamic, and disease progression model described the anti-inflammatory effects of NPX in collagen-induced arthritic (CIA) male and female rats. (aspetjournals.org)
  • Paw volumes of healthy rats indicated natural growth, and disease status was measured by paw edema. (aspetjournals.org)
  • This supports our hypothesis that podocyte-matrix interaction via collagen receptors plays an important part in progression of renal fibrosis in Alport disease. (uzh.ch)
  • Oxytocin itself may cause uterine contractions and thus Collagen vascular disease and pregnancy can cross-react with oxytocin receptors and trigger contractions. (pumkinlittle.com)
  • Transfer of these in vitro-activated B cells into collagen-immunized DBA/1 with transgenic T-cell receptors specific for collagen significantly delayed disease onset and ameliorated established disease. (igf-1r.com)
  • Collagen vascular disorders makes one susceptible to high blood pressure and its consequences such as intra-uterine growth restriction, kidney & liver dysfunction , low platelet count , etc. (healthtap.com)
  • Results: Contraction of the FPCLs occurred significantly faster and to a greater extent in disease cells compared to control cells. (uwo.ca)
  • In this presentation, I will decode the temporal and spatial demyelinating processes in collagen diseases and show practical approaches and treatments. (biomedcentral.com)
  • This group of diseases usually affects adults in their 30s and 40s. (healthline.com)
  • Hip Dysplasia - Hip dysplasia affects dogs more commonly than any other diseases, and although it is a disease that can develop in humans as well, it is generally thought of as a canine disease. (k9collagen.com)
  • Legg-Calvé-Perthes Syndrome - Legg-Calvé-Perthes Syndrome, also referred to as Perthes Disease, is another disease that affects the hips. (k9collagen.com)
  • More often than not this is a disease that affects younger dogs, as well as smaller breeds, unlike most skeletal diseases that tend to affect larger, older dogs. (k9collagen.com)