Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)
A condition characterized by the presence of RHEUMATOID ARTHRITIS associated with a specific form of pneumoconiosis, often in coal miners and asbestos workers.
An accumulation of purulent material in the space between the PHARYNX and the CERVICAL VERTEBRAE. This usually results from SUPPURATION of retropharyngeal LYMPH NODES in patients with UPPER RESPIRATORY TRACT INFECTIONS, perforation of the pharynx, or head and neck injuries.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A branch of internal medicine concerned with the diagnosis and treatment of INFECTIOUS DISEASES.
A publication issued at stated, more or less regular, intervals.
A selective serotonin reuptake inhibitor that is used in the treatment of DEPRESSION and a variety of ANXIETY DISORDERS.
The act or practice of calling public attention to a product, service, need, etc., especially by paid announcements in newspapers, magazines, on radio, or on television. (Random House Unabridged Dictionary, 2d ed)
Aspects of health and disease related to travel.
A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE), found in Australia and New Guinea. It causes a fulminating viremia resembling Japanese encephalitis (ENCEPHALITIS, JAPANESE).
The ginseng plant family of the order Apiales, subclass Rosidae, class Magnoliopsida. Leaves are generally alternate, large, and compound. Flowers are five-parted and arranged in compound flat-topped umbels. The fruit is a berry or (rarely) a drupe (a one-seeded fruit). It is well known for plant preparations used as adaptogens (immune support and anti-fatigue).
An abnormal protein with unusual thermosolubility characteristics that is found in the urine of patients with MULTIPLE MYELOMA.
Infections of the brain caused by arthropod-borne viruses (i.e., arboviruses) primarily from the families TOGAVIRIDAE; FLAVIVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; and RHABDOVIRIDAE. Life cycles of these viruses are characterized by ZOONOSES, with birds and lower mammals serving as intermediate hosts. The virus is transmitted to humans by the bite of mosquitoes (CULICIDAE) or TICKS. Clinical manifestations include fever, headache, alterations of mentation, focal neurologic deficits, and COMA. (From Clin Microbiol Rev 1994 Jan;7(1):89-116; Walton, Brain's Diseases of the Nervous System, 10th ed, p321)
A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.
A genus of FLAVIVIRIDAE containing several subgroups and many species. Most are arboviruses transmitted by mosquitoes or ticks. The type species is YELLOW FEVER VIRUS.
Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.
Acute or chronic pain in the lumbar or sacral regions, which may be associated with musculo-ligamentous SPRAINS AND STRAINS; INTERVERTEBRAL DISK DISPLACEMENT; and other conditions.
Aching sensation that persists for more than a few months. It may or may not be associated with trauma or disease, and may persist after the initial injury has healed. Its localization, character, and timing are more vague than with acute pain.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
Motion picture study of successive images appearing on a fluoroscopic screen.
Diseases characterized by inflammation involving multiple muscles. This may occur as an acute or chronic condition associated with medication toxicity (DRUG TOXICITY); CONNECTIVE TISSUE DISEASES; infections; malignant NEOPLASMS; and other disorders. The term polymyositis is frequently used to refer to a specific clinical entity characterized by subacute or slowly progressing symmetrical weakness primarily affecting the proximal limb and trunk muscles. The illness may occur at any age, but is most frequent in the fourth to sixth decade of life. Weakness of pharyngeal and laryngeal muscles, interstitial lung disease, and inflammation of the myocardium may also occur. Muscle biopsy reveals widespread destruction of segments of muscle fibers and an inflammatory cellular response. (Adams et al., Principles of Neurology, 6th ed, pp1404-9)
Measurement of the pressure or tension of liquids or gases with a manometer.
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
Disorders affecting the motor function of the UPPER ESOPHAGEAL SPHINCTER; LOWER ESOPHAGEAL SPHINCTER; the ESOPHAGUS body, or a combination of these parts. The failure of the sphincters to maintain a tonic pressure may result in gastric reflux of food and acid into the esophagus (GASTROESOPHAGEAL REFLUX). Other disorders include hypermotility (spastic disorders) and markedly increased amplitude in contraction (nutcracker esophagus).
Professional society representing the field of nursing.
The recognition of professional or technical competence through registration, certification, licensure, admission to association membership, the award of a diploma or degree, etc.
Certification as complying with a standard set by non-governmental organizations, applied for by institutions, programs, and facilities on a voluntary basis.
Educational programs designed to inform physicians of recent advances in their field.
Compliance with a set of standards defined by non-governmental organizations. Certification is applied for by individuals on a voluntary basis and represents a professional status when achieved, e.g., certification for a medical specialty.
Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.
It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)
Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
Further or repeated use of equipment, instruments, devices, or materials. It includes additional use regardless of the original intent of the producer as to disposability or durability. It does not include the repeated use of fluids or solutions.
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.

Detection of anti-cytokeratin 8 antibody in the serum of patients with cryptogenic fibrosing alveolitis and pulmonary fibrosis associated with collagen vascular disorders. (1/154)

BACKGROUND: It has been suggested that the humoral immune system plays a role in the pathogenesis of cryptogenic fibrosing alveolitis (CFA). Although circulating autoantibodies to lung protein(s) have been suggested, none of the lung proteins have been characterised. The purpose of this study was to determine the antigen to which the serum from patients with pulmonary fibrosis reacted. METHODS: The anti-A549 cell antibody was characterised in a patient with CFA using Western immunoblotting and immunohistochemical staining of A549 cells. As we identified that one of the antibodies against A549 cells was anti-cytokeratin 8, the expression of mRNA of cytokeratin 8 in A549 cells was evaluated. In addition, we attempted to establish an enzyme linked immunosorbent assay to measure the levels of anti-cytokeratin 8 antibody in the serum of patients with CFA and pulmonary fibrosis associated with collagen vascular disorders (PF-CVD). RESULTS: Initially two anti-A549 cell antibodies were detected in the serum of patients with pulmonary fibrosis, one of which was characterised as anticytokeratin 8 antibody by Western immunoblotting. We were able to establish an ELISA to measure anti-cytokeratin 8 antibody and found significantly higher levels in patients with CFA and PF-CVD than in normal volunteers, patients with sarcoidosis, pneumonia, and pulmonary emphysema. CONCLUSIONS: One of the anti-A549 cell antibodies in the serum of patients with CFA was against cytokeratin 8. The serum levels of anti-cytokeratin 8 antibody were increased in patients with CFA and PF-CVD. These results suggest that anticytokeratin 8 antibody may be involved in the process of lung injury in pulmonary fibrosis.  (+info)

Collagenous gastritis and collagenous colitis: a report with sequential histological and ultrastructural findings. (2/154)

The case is reported of a young adult man with collagenous gastritis, an extremely rare disorder with only three case reports in the English literature, who subsequently presented with collagenous colitis. Sequential gastric biopsies showed a notable increase in thickness of the subepithelial collagen band. Ultrastructural study of gastric and rectal mucosa showed the characteristic subepithelial band composed of haphazardly arranged collagen fibres, prominent degranulating eosinophils, and activated pericryptal fibroblasts.  (+info)

Elevated serum and BAL cytokeratin 19 fragment in pulmonary fibrosis and acute interstitial pneumonia. (3/154)

Cytokeratin 19 fragment (CK19) levels in serum have already been documented as a useful tumour marker for lung cancer. In the present study, it was hypothesized that CK19 may be increased in the serum and epithelial lining fluid of the respiratory tract from patients with pulmonary fibrosis. CK19 was measured in the serum and bronchoalveolar lavage fluid (BALF) of patients with pulmonary fibrosis and the correlation between CK19 levels and clinical parameters evaluated. Nineteen patients diagnosed with idiopathic pulmonary fibrosis (IPF), eight with pulmonary fibrosis associated with a collagen vascular disorder (PF-CVD), seven patients with acute interstitial pneumonia (AIP), and 10 normal smokers as a control group were studied. CK19 levels in sera of patients with IPF and patients with PF-CVD were significantly increased compared to those of normal smokers. CK19 levels in sera of patients with AIP were significantly increased compared to those of other groups. CK19 values in the BALF of patients with pulmonary fibrosis were significantly elevated compared to those of normal smokers. CK19 values in sera charged according to the progression or improvement of the acute lung injury. Immunohistochemical study using pulmonary tissues obtained from patients with AIP demonstrated that the hyaline membrane and proliferating type II pneumocytes were stained by anti-human cytokeratin 19 antibody. These data demonstrated that the measurement of cytokeratin 19 fragment is a useful parameter to evaluate the activity of lung epithelial cell damage and repair.  (+info)

Collagen dysplasia (cutaneous asthenia) in a cat. (4/154)

Hereditary collagen dysplasias comprise a complex group of connective-tissue disorders that result in the reduced tensile strength of affected tissues. These processes are called cutaneous asthenia in the skin of dogs and cats. We report here the case of a crossbred male cat, aged 6 months, that presented with two skin wounds in the region of the right thorax and right iliac tuberosity. The skin of these regions and of the animal's dorsum was hyperextensible, smooth to the touch, and easily torn with minor trauma. Microscopic examination of skin samples revealed reduced dermal connective tissue consisting of shortened and fragmented collagen fibers. Normal fibers were intermingled with altered fibers. Ultrastructural changes in collagen fibers included disorientation of fibrils within the same bundle, marked spacing differences, and variation in the diameter of transverse sections. The fibrils maintained the transverse striations characteristic of normal collagen.  (+info)

Report of five novel and one recurrent COL2A1 mutations with analysis of genotype-phenotype correlation in patients with a lethal type II collagen disorder. (5/154)

Achondrogenesis II-hypochondrogenesis and severe spondyloepiphyseal dysplasia congenita (SEDC) are lethal forms of dwarfism caused by dominant mutations in the type II collagen gene (COL2A1). To identify the underlying defect in seven cases with this group of conditions, we used the combined strategy of cartilage protein analysis and COL2A1 mutation analysis. Overmodified type II collagen and the presence of type I collagen was found in the cartilage matrix of all seven cases. Five patients were heterozygous for a nucleotide change that predicted a glycine substitution in the triple helical domain (G313S, G517V, G571A, G910C, G943S). In all five cases, analysis of cartilage type II collagen suggested incorporation of the abnormal alpha1(II) chain in the extracellular collagen trimers. The G943S mutation has been reported previously in another unrelated patient with a strikingly similar phenotype, illustrating the possible specific effect of the mutation. The radiographically less severely affected patient was heterozygous for a 4 bp deletion in the splice donor site of intron 35, likely to result in aberrant splicing. One case was shown to be heterozygous for a single nucleotide change predicted to result in a T1191N substitution in the carboxy-propeptide of the proalpha1(II) collagen chain. Study of the clinical, radiographic, and morphological features of the seven cases supports evidence for a phenotypic continuum between achondrogenesis II-hypochondrogenesis and lethal SEDC and suggests a relationship between the amount of type I collagen in the cartilage and the severity of the phenotype.  (+info)

Clinical evaluation of idiopathic interstitial pneumonia and interstitial pneumonia associated with collagen vascular disease using logistic regression analysis. (6/154)

OBJECTIVE: To clarify the differences in the clinical features between idiopathic interstitial pneumonia (IIP) and interstitial pneumonia associated with collagen vascular diseases (CVD-IP). METHODS: Symptoms, radiographic findings, pulmonary function, blood chemistry data including autoantibody, and bronchoalveolar lavage fluid (BALF) findings were compared using multiple logistic regression analysis. PATIENTS: The subjects were 44 patients clinically diagnosed with IIP and 33 patients with CVD-IP. RESULTS: The clinical features related to IIP were as follows: male sex, advanced age, past history of hypertension, presence of cough, exertional dyspnea, digital clubbing, an increased level of gamma-globulin, decreased lung volume on chest X-ray, and typical type according to the criteria for IIP on chest X-ray. Increased levels of rheumatoid factor and total cell number in BALF were related to CVD-IP. CONCLUSION: These findings are considered to be useful to differentiate IIP and CVD-IP.  (+info)

Role of carbohydrate antigens sialyl Lewis (a) (CA19-9) in bronchoalveolar lavage in patients with pulmonary fibrosis. (7/154)

BACKGROUND: It has been reported that carbohydrate antigen sialyl Lewis (a) (CA19-9) levels are elevated in serum as well as in bronchoalveolar lavage fluid (BALF) of patients with pulmonary fibrosis. However, the biological significance of CA19-9 is unclear. OBJECTIVE: The purpose of the present study was to evaluate correlations between CA19-9 levels in BALF and several biochemical as well as clinical parameters in patients with pulmonary fibrosis. In addition, biological functions of CA19-9 were also examined. METHODS: We studied 24 patients with a diagnosis of pulmonary fibrosis: 16 with idiopathic pulmonary fibrosis (IPF) and 8 with pulmonary fibrosis associated with a collagen vascular disorder (PF-CVD). In BALF, carbohydrate antigens sialyl Lewis (a) (CA19-9), elastase: alpha(1)-proteinase inhibitor complex (E-PI), hepatocyte growth factor (HGF), LDH, IgG, IgA, albumin, and cell differentiation were measured. We also evaluated the effects of CA19-9 on neutrophil functions. RESULTS: CA19-9/albumin levels in BALF significantly correlated with HGF/albumin, elastase/albumin, LDH/albumin, total number of alveolar macrophages, and total number of neutrophils. Purified CA19-9 had a chemotactic activity for neutrophils. In addition, neutrophil chemotactic activity to C5a, fMLP, and interleukin 8 was significantly stimulated after incubation with purified CA19-9. Furthermore, CA19-9 increased the expression of CD15s on neutrophils. CONCLUSIONS: Our data demonstrated (i) CA19-9 in BALF correlated with other markers of inflammation in pulmonary fibrosis, and (ii) CA19-9 can modify neutrophil functions. These results suggest that CA19-9 may play a role in the process of lung injury in patients with pulmonary fibrosis.  (+info)

Alternate-day prednisone therapy and human lymphocyte subpopulations. (8/154)

The mechanisms and kinetics of the immunosuppressive effects of alternate-day prednisone were investigated in a group of patients with a variety of inflammatory diseases receiving a range of alternate-day prednisone doses from 5 to 120 mg. Total circulating lymphocyte and monocyte counts, as well as proportions of lymphocyte subpopulations defined both by surface markers and by in vitro functional capacities, were studied. At 8 a. m. of the day on prednisone, just before drug administration, lymphocyte and monocyte counts, proportions of lymphocyte subpopulations, as well as in vitro lymphocyte blastogenic responses to various mitogenic and antigenic stimuli were normal. 4 h after the administration of prednisone, there was a profound lymphocytopenia and monocytopenia, with a differential depletion of thymus-derived lymphocytes as well as various functionally defined lymphocyte subpopulations. Lymphocyte kinetic studies using a radioactive chromium-labeled autologous lymphocytes showed that the lymphocytopenia was due predominantly to a transient depletion of the recirculating portion of the intravascular lymphocytepool. All these parameters returned to normal by 8 a.m. of the following day (off prednisone) and remained normal throughout the day. This very transient lymphocytopenia and monocytopenia after prednisone, with normal cell numbers, proportions, and functions throughout the remainder of the 2-day cycle, was associated with suppression of disease activity, yet did not affect cutaneous delayed hypersensitivity in these patients nor increase the likelihood of infectious complications. This drug-associated cyclic and transient monocytopenia and selective lymphocytopenia is best explained by a redistribution of recirculating lymphocytes to other body compartments, particularly the bone marrow.  (+info)

Looking for Collagen-vascular disease? Find out information about Collagen-vascular disease. see autoimmune disease autoimmune disease, any of a number of abnormal conditions caused when the body produces antibodies to its own substances. Explanation of Collagen-vascular disease
collagen disease: see autoimmune disease; collagen. Source for information on collagen disease: The Columbia Encyclopedia, 6th ed. dictionary.
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Nonetheless, due to limited space we do ask that you invite no collagen vascular disease and pregnancy than 2 collaegn. With my 2nd youngster, I keep in mind getting that crampy feeling right after and it lasted for awhile. Now that a variety of hCG or human Chorionic Gonadotropin hormone is secreted within the physique extra meals aversions, sensitivity to odor, fatigue and constipation may be expected. As I discussed, these guys do not have these issues. Collahen involuntary leaking could occur when coughing, sneezing and collagen vascular disease and pregnancy laughing. As mentioned earlier, its not unusual for a woman to spot during her first 12 weeks of being pregnant. When crucial, I embrace further postpartum visits to insure that diseasd gets off to a terrific begin. Oxytocin itself may cause uterine contractions and thus Collagen vascular disease and pregnancy can cross-react with oxytocin receptors and trigger contractions. A prenatal multivitamin doesnt replace a healthy diet. Cite ...
Alport syndrome is a hereditary type IV collagen disease leading to progressive renal fibrosis, hearing loss and ocular changes. End stage renal failure usually develops during adolescence. COL4A3-/- mice serve as an animal model for progressive renal scarring in Alport syndrome. The present study evaluates the role of Discoidin Domain Receptor 1 (DDR1) in cell-matrix interaction involved in pathogenesis of Alport syndrome including renal inflammation and fibrosis. DDR1/COL4A3 Double-knockouts were compared to COL4A3-/- mice with 50% or 100% expression of DDR1, wildtype controls and to DDR1-/- COL4A3+/+ controls for over 6years. Double-knockouts lived 47% longer, mice with 50% DDR1 lived 29% longer and showed improved renal function (reduction in proteinuria and blood urea nitrogen) compared to animals with 100% DDR1 expression. Loss of DDR1 reduced proinflammatory, profibrotic cells via signaling of TGFbeta, CTGF, NFkappaB and IL-6 and decreased deposition of extracellular matrix. ...
title:Socio Demographic Profile and Clinical Presentation of Collagen Vascular Disease with Pulmonary Symptoms: A Descriptive Cross Sectional Study. Author:Parul Vadgama, Mehul Bhavsar, Kusum V Shah, Rajesh Solanki, Ramakant Dixit, Jignesh Vaishnani. Keywords:Collagen vascular disease, pulmonary symptoms, sceroderma, rheumatoid arthritis. Type:Original Article. Abstract:Introduction: Collagen Vascular Disease presented with varied systemic symptoms including pulmonary symptoms, commonly breathless on exertion; dry cough; cough with expectoration; chest pain; and hemoptysis. The current study was conducted to know socio demographic profile and clinical presentation of patient coming with Collagen Vascular Disease having pulmonary symptoms. Methodology: This was a descriptive cross sectional study conducted among Collagen Vascular Disease patient coming with pulmonary symptoms in outpatient department. Results: Among the 50 patients 40% patients were having SC followed by SLE (30%). Most common ...
Collagen-vascular diseases; systemic lupus erythematosus, acute dermatomyositis-polymyositis, progressive systemic sclerosis, polyarteritis nodosa by John Harold Talbott Download PDF EPUB ...
Question - I have a past history of collagen vascular disease and leukopenia. Is swollen bulging eye and pain behind the ear a symptom of connective tissue disease and autoimmune thyroid ?. Ask a Doctor about Thyroid, Ask a Hematologist
List of causes of Collagen vascular diseases causing fever and Dry scalp in children and Food symptoms and Heart symptoms and Metacarpophalangeal joint sensitive, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
List of causes of Aches and Breathing difficulties and Collagen vascular diseases causing fever and Food symptoms and Heart symptoms and Metacarpophalangeal joint sensitive, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
Terkko Navigator is a medical library community for the University of Helsinki and Helsinki University Central Hospital. Personalize your own library of feeds, journals, books, links and more ⇒ ⇒
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Wet-lab validated real-time PCR primer assays for your biological pathway of interest. Select your gene target of interest using an interactive pathway map, and select your plate.
B. Often the diagnosis is obscured procsar of the severe degree proscar in thailand kidney destruction. Pedrotti, is associated with rheumatoid arthritis (or other collagen disease) in approximately Prтscar of patients (see section on Scleritis in Chapter 8), and approximately 45 have a known systemic condition.
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Prednisolone is used for treating allergies, arthritis, breathing problems (e.g., asthma), certain blood disorders, collagen diseases (e.g., lupus), certain eye diseases (e.g., keratitis), cancer (e.g., leukemia), endocrine problems (e.g., adrenocortical insufficiency), intestinal problems (e.g., ulcerative colitis), swelling due to certain conditions, or skin conditions (e.g., psoriasis). GenericsBestBuy Have Best Offers. Price From 0.48.
Prednisolone is used for treating allergies, arthritis, breathing problems (e.g., asthma), certain blood disorders, collagen diseases (e.g., lupus), certain eye diseases (e.g., keratitis), cancer (e.g., leukemia), endocrine problems (e.g., adrenocortical insufficiency), intestinal problems (e.g., ulcerative colitis), swelling due to certain conditions, or skin conditions (e.g., psoriasis). It may also be used for other conditions as determined by your doctor ...
Prednisolone is used for treating allergies, arthritis, breathing problems (e.g., asthma), certain blood disorders, collagen diseases (e.g., lupus), certain eye diseases (e.g., keratitis), cancer (e.g., leukemia), endocrine problems (e.g., adrenocortical insufficiency), intestinal problems (e.g., ulcerative colitis), swelling due to certain conditions, or skin conditions (e.g., psoriasis). It may also be used for other conditions as determined by your doctor ...
Prednisolone (Predonema). Prednisolone is used for treating allergies, arthritis, breathing problems (eg, asthma), certain blood disorders, collagen diseases (eg, lupus), certain eye diseases (eg, keratitis), cancer (eg, leukemia), endocrine problems (eg, adrenocortical insufficiency), intestinal problems (eg, ulcerative colitis), swelling due to certain conditions, or skin conditions (eg, psoriasis).. Other names for this medication. Adelcort, Adelone, Aersolin d, Ak-pred, Alertine, Alpicort, Apicort, Aprednislon, Bisuo a, Blephamide, Bronal, Capsoid, Cetapred, Chloramphecort-h, Compesolon, Cor tyzine, Corotrope, Cortan, Cortico-sol, Cortisal, Cortisol, Danalone, Decortin h, Delta-cortef, Deltacortenesol, Deltacortril, Deltahydrocortisone, Deltapred, Deltastab, Dermol, Dermosolon, Deturgylone, Dhasolone, Di-adreson-f, Dojilon, Dontisolon, Econopred, Emsolone, Encortolon, Estilsona, Fenicort, Fisiopred, Fisopred, Flo-pred, Frisolona forte, Glucortin, Gupisone, Hefasolon, Hexacorton, ...
Prednisolone is used for treating allergies, arthritis, breathing problems (e.g., asthma), certain blood disorders, collagen diseases (e.g., lupus), certain eye diseases (e.g., keratitis), cancer (e.g., leukemia), endocrine problems (e.g., adrenocortical insufficiency), intestinal problems (e.g., ulcerative colitis), swelling due to certain conditions, or skin conditions (e.g., psoriasis ...
Prednisolone (Solu-decortin). Prednisolone is used for treating allergies, arthritis, breathing problems (eg, asthma), certain blood disorders, collagen diseases (eg, lupus), certain eye diseases (eg, keratitis), cancer (eg, leukemia), endocrine problems (eg, adrenocortical insufficiency), intestinal problems (eg, ulcerative colitis), swelling due to certain conditions, or skin conditions (eg, psoriasis).. Other names for this medication. Adelcort, Adelone, Aersolin d, Ak-pred, Alertine, Alpicort, Apicort, Aprednislon, Bisuo a, Blephamide, Bronal, Capsoid, Cetapred, Chloramphecort-h, Compesolon, Cor tyzine, Corotrope, Cortan, Cortico-sol, Cortisal, Cortisol, Danalone, Decortin h, Delta-cortef, Deltacortenesol, Deltacortril, Deltahydrocortisone, Deltapred, Deltastab, Dermol, Dermosolon, Deturgylone, Dhasolone, Di-adreson-f, Dojilon, Dontisolon, Econopred, Emsolone, Encortolon, Estilsona, Fenicort, Fisiopred, Fisopred, Flo-pred, Frisolona forte, Glucortin, Gupisone, Hefasolon, Hexacorton, ...
Alarsin R.Compound is indicated in Rheumatic, Arthritic, Collagen diseases. Acute Soft Tissue Trauma. Dental Traumatic conditions. - Arthritis / Joint / Knee
Prednisolone is used for treating allergies, arthritis, breathing problems (e.g., asthma), certain blood disorders, collagen diseases (e.g., lupus), certain eye diseases (e.g., keratitis), cancer (e.g., leukemia), endocrine problems (e.g., adrenocort ...
Alport syndrome (AS) is a hereditary type IV collagen disease that leads to progressive proteinuria, renal fibrosis, and kidney failure. Depending on the mutated gene and the pattern of inheritance, there are three types ...
Hydrocortisone (Science: chemical) (11 beta)-11,17,21-trihydroxypregn-4-ene-3,20-dione. The main glucocorticoid secreted by the adrenal cortex. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions. Pharmacological action: steroidal anti-inflammatory agents. chemical name: Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11beta)- ...
Identification of the molecular defect in patients with type II collagen disorders is usually a challenge because of the relatively large size and complexity of the COL2A1 gene and its main expression in cartilage. Cartilage is not easily accessible, relatively acellular, and therefore a poor source of mRNA for cDNA synthesis and analysis. Furthermore, sufficient amounts of mRNA can often not be obtained from cultured skin fibroblasts or lymphocytes owing to low basal transcription of the gene. Therefore, mutation analysis of the COL2A1 gene is often performed in the genomic DNA in a head to tail fashion, which is time consuming and laborious. In this study, we used the opportunity of having cartilage tissue for exploring the genetic defect in the COL2A1 gene in seven patients with a lethal type II collagen disorder. Those regions of theCOL2A1 gene in which a mutation was likely to reside, based on the overmodification pattern of the type II collagen CB peptides, were screened first with SSCP ...
collagen refers to a group of proteins which are the main component of connective tissue and the most abundant protein in mammals making up 25-35% of total body protein ...
Clinical. Scleroderma is a collagen-vascular disease characterized by diffuse fibrosis, degenerative changes, and vascular abnormalities in the skin, articular structures and other organs (kidneys, lung, heart, gastrointestinal and skeletal muscles). Esophageal involvement occurs in 75 to 87% of patients with scleroderma. In the esophagus, aperistalsis results from atrophy or cellular disruption of esophageal smooth muscle including the LES. These changes are primarily limited to the lower two-thirds of the esophagus because the upper third is composed of striated muscle. Patients often present with symptoms of reflux secondary to LES incompetence and dysphagia may result from abnormal motility, reflux esophagitis or peptic stricture formation. Radiological findings. Barium studies may demonstrate a normal stripping wave that clears the upper esophagus, but stops at the level of the aortic arch. This is can be attributed to the striated muscle that composes the upper third of the esophagus. In ...
Neurologic symptoms similar with those in multiple sclerosis appear in collagen-vascular diseases, Lyme disease, rare hereditary disorders, and AIDS so, although blood tests are highly recommended th...
All patients in the ONTT had blood testing to exclude collagen vascular disease (antinuclear antibody), syphilis (FTA-ABS), and a chest x-ray to detect sarcoidosis. A lumbar puncture was optional and was performed in 141 patients. Antinuclear antibody was positive in a titer 1:320 or greater in 3% of patients. Of these patients, only one developed a connective tissue disease in the first two years of follow up. FTA-ABS was positive in 1.3% of the patients, and none were judged to have syphilis. A chest x-ray did not SHOW evidence of sarcoidosis in any patients. CSF analysis never yielded unsuspected information. Based on these results, chest x-ray, blood tests, and lumbar puncture are deemed not to be necessary in evaluating patients with typical clinical features of optic neuritis ...
Cavitary pneumonia is a disease in which the normal lung architecture is replaced by a cavity. In a healthy lung, oxygen transport occurs at the level of the alveoli, each of which has an average size of 0.1 mm. These air spaces can become enlarged by a number of processes: bacterial infection (tuberculosis), fungal infection, vasculitis (granulomatosis with polyangiitis), collagen vascular disease (Sjögrens syndrome) or granulomatous disease (sarcoidosis). ...
Evidence of areas of irregular predominately peripheral consolidation in the right lower lobe with few areas of ground glass haze and nodular shadows. There is larger shadow in the left lower lobe with peripheral consolidation with airbronchogram surrounding relatively preserved lung parenchyma. There are areas of ground glass haze. The appearance in left lower lobe is suggestive of reverse halo sign or atoll sign which is classical of cryptogenic organising pneumonia versus differentials of this appearance. The cryptogenic organizing pneumonia in the majority of cases is an idiopathic disease, while less frequently it can be associated with infectious pneumonias, airway obstruction, aspiration, drug reaction, or collagen vascular disease associated with an intake of toxic substances. The prognosis is favourable because there is a good response to steroid therapyThis needs clinical correlation and follow up. ...
Author:Parul Vadgama, Mehul Bhavsar, Kusum V Shah, Rajesh Solanki, Ramakant Dixit, Jignesh Vaishnani. Keywords:Collagen vascular disease, pulmonary symptoms, sceroderma, rheumatoid arthritis. Type:Original Article. Full PDF Abstract ...
Gammadyn Cu-Au-Ag can be used to help arthritis, chronic rheumatism, skin and collagen disorders such as psoriasis and acne, immune depletion and infectious diseases
Vascular disorders can be classified into five groups: traumatic, compressive, occlusive, tumors/malformations and vasospastic. These problems may occur more commonly in individuals with certain diseases such as diabetes, hypertension, or kidney failure, or in dialysis patients.
ICD-9 code 593.81 for Vascular disorders of kidney is a medical classification as listed by WHO under the range - OTHER DISEASES OF URINARY SYSTEM (59
This volume on CVDs, renal, and respiratory disorders has particularly high value. It carries the potential to become the most effective game-changer in global health by helping all countries to combat, contain, and control the biggest killer presently prowling the globe and by enabling us to reach the 2030 goals for NCDs and health overall. As one who has witnessed the epidemic of CVDs advance menacingly across the world in the past four decades, I fervently hope that the clear and convincing messages conveyed by the extensively researched and elegantly communicated analyses in this volume will be heard, heeded, and harmonized with policy and practice in all countries ...
This is the first prospective study comparing the diagnostic accuracy of cineradiography and infused intraluminal manometry in approximately equal numbers of patients with scleroderma, polymyositis, systemic lupus erythematosus (SLE), and rheumatoid arthritis. Major criteria for inclusion of patients were as follows: scleroderma, characteristic generalized skin and visceral lesions; polymyositis, proximal muscle weakness and characteristic biopsy, rash, or electromyogram; SLE, positive antinuclear factor with several of the following-polyarthritis, butterfly rash, unexplained nephritis, or polyserositis; and rheumatoid arthritis, classical disease as diagnosed by American Rheumatism Association criteria. No patients had dysphagia at the time of evaluation. After classification, esophageal manometry and cineradiography ...
A 66-year-old male complained of thickening of the skin at the face, posterior neck and back after a febrile episode. The patient had obesity, elevated levels of HbA1C and urinary C-peptide. The seological tests for collagen diseases were negative. The serum level of vascular endothelial growth factor (VEGF) was elevated. The biopsied skin specimen revealed the thickening of the dermis by the increased proliferation of collagen fibers, thickening of collagen bundles with fenestrations and infiltration of lymphocytes. Scleredema caused by diabestes mellitus and obesity was diagnosed, accompanied with insulin resistance. The patient was initially treated with administration of prednisolone, followed with diet therapy. Scleredema ameliorated partially, however elevated level of VEGF persisted after 6 months of discharge. It is unclear whether elevated level of VEGF may be related to the pathogenesis of the disease or may be an aggravating factor ...
Connective tissue diseases by Graham R. V. Hughes; 4 editions; First published in 1977; Subjects: Collagen diseases, Connective Tissue Diseases, Connective Tissue, Diseases, Connective tissues, Internet Archive Wishlist
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ogren syndrome, Sjogren-Larsson syndrome, Skeletal dysplasia, Skeletal muscle disease, Skin collagen disease, Skin vascular disease, Sleep disorder, Sleeping seekness, Sly disease, Small bowel adenocarcinoma, Small bowel leiomyosarcoma, Small non-cleaved cell lymphoma, Smith martin dodd syndrome, Smith-Fineman-Myers syndrome, Smith-Lemli-Opitz syndrome, Smith-Magenis syndrome, Sneddon syndrome, Sneddon-Wilkinson disease, Snyder-Robinson syndrome, Soft tissue perineurioma, Soft tissue sarcomas, Sohval soffer syndrome, Solitary plasmacytoma, Solomon syndrome, Somatotroph adenoma, Sommer hines syndrome, Sommer rathbun battles syndrome, Sommer-Young-Wee-Frye syndrome, Sondheimer syndrome, Sonoda syndrome, Sorsby syndrome, Sorsbys fundus dystrophy, Sotos syndrome, Spastic paraplegia, Spellacy gibbs watts syndrome, Spherophakia-brachymorphia, Sphingolipidosis, Spina bifida, Spinal atrophy, Spirillosis, Splenic marginal zone lymphoma, Spondylarthropathy, Spondylo camptodactyly syndrome, Spondylocostal ...
Collagen diseases such as systemic lupus erythematosis, Sjogrens syndrome, scleroderma and arthritis also cause muscular pain in the head and neck. Lupus is characterized by a butterfly rash of the face, fever, rheumatoid arthitis and pleural and abdominal pain. Laboratory studies reveal a high sedimentation rate, hypochromic anemia, a positive ANA test and a false-positive VDRL. Scleroderma is characterized by gradual onset of muscle and joint pain leading to a systemic sclerosis with anorexia, dyspnea and diminished sweating. Fever, skin lesions and limited jaw and chest expansion are seen. Sjogrens syndrome is characterized by dryness of the mouth, eye and skin and oftentimes, muscle and joint pain. Rheumatoid arthritis is a chronic inflammation of the synovial membrane with pain in the muscles and joints. Numerous joints in the body are usually affected, and pain usually decreases with use. Fatigue, fever, muscle pain, night sweats and sometimes weight loss are seen. Studies show the ...
In 1875 Paget described subclavian vein thrombosis and in 1884 Schröetter proposed that subclavian vein thrombosis was the result of excessive upper extremity activity. In 1949, the surgeon Hughes coined the term Paget-Schröetter syndrome for patients with occlusion of the subclavian vein following overuse of the upper extremity [1, 3, 6].. DVT occurs more commonly in the veins of the pelvis or the lower extremities. In two previous reports, the incidence of upper extremity DVT has been cited as occurring in approximately 4 to 11 % of all cases of thromboembolism. DVT is classified as either primary or secondary, depending of the cause of the thrombus. Primary or idiopathic upper extremity DVT is less common than secondary, only accounting for 2 in 100,000 cases per year [7, 8]. Secondary DVT is more common and can be caused by central venous catheters, cardiac devices, neoplasias, or collagen diseases. Thrombosis of the upper extremity veins is usually related to effort in conjunction with ...
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Patients with existing blood vessel aneurysms (such as abnormalities in brain blood vessels or aortic aneurysms), atherosclerotic disease (hardening of the arteries, including carotid artery disease), collagen disorders, vasculitis, other underlying blood vessel abnormalities, or collagen vascular diseases (such as systemic lupus erythematosus) may be at increased risk of stroke or blood vessel dissection (525;526). Individuals with osteomyelitis (bone infection) (527), cancer involving bone (502), vertebral fractures, severe degenerative joint disease (osteoarthritis), osteoporosis, and ankylosing spondylitis may be at increased risk of fracture or spinal damage leading to nerve disorders or spinal cord damage (528-530). Prior surgery of the trachea or tracheostomy may increase the risk of tracheal rupture (531). Underlying tumors of the brain or near the spinal cord may result in adverse outcomes such as tumor rupture or delayed diagnosis (532-537). Patients with blood clotting disorders or ...
A total of 187 specimens from 142 subjects with rheumatoid arthritis, systemic lupus erythematosus, other connective tissue diseases, and controls were placed in cell culture. Specimens from 119 of the subjects grew, lasting over 2 yr in several instances. No evidence of virus infection has been found by a variety of sensitive methods, including cell fusion. Other approaches have likewise failed thus far to implicate any virus in the pathogenesis of rheumatoid arthritis.. ...
ICD M30-M36 Systemic connective tissue disorders  autoimmune disease NOS collagen (vascular) disease NOS systemic autoimmune disease systemic collagen
BIOWARFARE RESEARCH Between 1942 and the present time, biological warfare research has resulted in a more deadly and infectious form of the mycoplasma. They extracted this mycoplasma from the brucellosis bacteria, weaponized it and actually reduced the disease to a crystalline form. According to Dr. Shyh-Ching Lo, one of Americas top, top researchers, this disease agent, the mycoplasma, causes among other things, AIDS, chronic fatigue syndrome, multiple sclerosis, Wegeners disease, Parkinsons disease, Crohns colitis, Type I diabetes, and collagen-vascular diseases such as rheumatoid arthritis and Alzheimers. The mycoplasma enters into the individual cells of the body depending upon your genetic predisposition. You may develop neurological diseases if the pathogen destroys certain cells in your brain, or you may develop Crohns colitis if the pathogen invades and destroys cells in the lower bowel. Once it gets into the cell, it can lie there doing nothing sometimes for 10, 20 or 30 years, ...
INTRODUCTION Organizing pneumonia (OP) is a type of diffuse interstitial lung disease characterized by a specific histopathologic pattern of response to lung injury. When the etiology of the injury is unknown and in the absence of inflammatory or connective tissue disease, this entity is termed cryptogenic organizing pneumonia (COP) or primary organizing pneumonia (POP). Disease states in which the etiology of underlying injury is known is termed secondary organizing pneumonia (SOP). Causes of SOP include drug toxicity, chronic heart or renal failure, rheumatic disease, collagen vascular disease, infection, immunodeficiency, autoimmune disease, and interstitial lung disease. OP is characterized by the accumulation of inflammatory cells, fibroblasts, and myofibroblasts in the lumens of bronchioles and alveoli creating plugs of debris. This leads to alveolar epithelial injury, which is followed by leakage of plasma cells and the recruitment of fibroblasts and fibrin within the alveolar lumen. This
The Department of Rheumatology at Columbia Asia Hospital - Whitefield, Bangalore provides diagnosis, treatment and rehabilitation for adults and children with rheumatic and related disorders. Chronic diseases like rheumatoid arthritis, osteoarthritis, gout, pseudogout and fibromyalgia are some of the diseases commonly treated. Other diseases managed are collagen vascular diseases like Systemic Lupus Erythematosus (SLE), Poly Arteritis Nodosa (PAN) and Sjögrens syndrome. Rheumatic diseases affect many parts of the body, hence multi-disciplinary care is required and treatment is customized for each patient. The consultants also use different modes of therapy like pain medications, anti-inflammatory medications, chemotherapeutic agents and intra-articular steroids.. The focus is on alleviating pain, improving quality of life and prolonging the life expectancy of patients with chronic rheumatic diseases. The department is supported by physiotherapists and occupational therapists.. ...
Have compromised ability for wound healing, such as: malnutrition, oral steroid use, history of collagen vascular disease (e.g. lupus, scleroderma, history of keloid formation (raised and thickened scars), atrophic dermatitis (extreme skin irritation or itchiness) or immunologic abnormalities such as vitiligo (white patches of skin due to loss of pigment ...
Introduction. Recent advances in therapy make early identification of patients with Pulmonary Hypertension (PH) important. The 2008 consensus statement reported an average UK treatment rate of 24.9 per million.(1). Aim. Our institution is a District General Hospital serving a population of 330,000. Our aim was to compare our treatment rate to the national average since the appointment of a physician with an interest in PH.. Method. Retrospective casenote review of patients attending our monthly PH clinic since 2006.. Results. We identified 102 Outpatient and 35 Inpatient referrals. 28 went on to receive specialist treatment for PH; mean age 66 (range 36-85); 24 female 4 male. Diagnoses: Chronic thromboembolic 10, Idiopathic 8, Collagen vascular disease 5, Congenital left to right shunt 2, COPD 2 and Portal hypertension 1. Haemodynamics (mean): Cardiac catheter: mean Pulmonary Artery Pressure (PAP) 48mmHg (n=22, range 22-78), cardiac output 4.8 (n=21, range 2.5-7.7), cardiac index 2.83 (n=22, ...
Erythrocyte sedimentation rate (ESR) can be defined as the rate at which red blood cells or erythrocytes sediment in a period of one hour. ESR is usually measured in millimeter per hour (mm/hr) and a value above 100 mm/hr indicates a disease condition, such as a disease that causes inflammation, active infection, cancer, heart disease, kidney disease, blood disease, diabetes, and collagen vascular disease. However, ESR is a non-specific test for inflammation and is used in conjunction with other tests such as C-reactive protein. Normal ESR result does not rule out the possibility of inflammation. Similarly, an elevated ESR without any symptoms of the disease does not aid in making any medical decision. ESR analyzers are devices employed to measure the sedimentation rate of erythrocytes for an accurate reading. Automated ESR analyzers need to comply with the 2011-published Clinical and Laboratory Standards Institute (CLSI) guidelines for measuring ESR. The analyzer works on the basic principle of ...
In an effort to understand the reasons behind people of any age, including children, being struck down with Rheumatoid Arthritis (RA) and other connective tissue diseases, we have delved and found some valuable and exciting conventional medical research.. The book The New Arthritis Breakthrough chronicles some 50 years of research and successful treatment of over 10,000 patients by the eminent US doctor Thomas McPherson Brown. It cites clinical trials that have repeatedly shown the link between bacteria and the inflammatory process that causes RA and other connective tissue diseases. Trial results show how these debilitating conditions are responsive to low dose antibiotic therapy. Patient reports in the book tell how antibiotic therapy has allowed them to discontinue cortisone, anti inflammatories and immuno-suppressant medications and regain a normal life after years of pain, debility, surgery, unemployment and untold difficulty.. In addition to results that are thought impossible for ...
You need to find a doctor who will listen...good luck finding one who keeps their ego in check. University Hospital ER rooms are often good places because I have found that they are so overly careful. OU and OSU in Oklahoma have great specialist. I have all the same symptoms and went years being told I had various weird but normal problems. After an ER visit because I felt I was dying, the Doc kept me for several days. During this time he discovered a 38 year old secret...I had lived with Ehlers Danlos my entire life without a diagnosis. There are six types, but in a nutshell, they are all Collagen disorders. This means the body doesnt make collagen properly. This causes tons of problems as 80 percent of the body is collagen. It is very painful, but we look normal, not only normal, but good! But we hurt, those nodes, those are common with Ehlers, we live with these problems, have surgery when we need it, but only when we need it! Look it up. If Im wrong what will it hurt? People are ignoring ...
Article from Fibromyalgia News Today (FNT) - Skin of Fibromyalgia Patients Could Provide Disease Clue Id like to share this interesting, but short article that has expanded my opinion about the link between Fibro, inflammatory/autoimmune disorders and Connective Tissue/Collagen Disorders. Via this link: Skin of Fibromyalgia Patients Could Provide Disease Clues Via: Fibromyalgia News Today.…
In Taiwan, ,2,000,000 people have a habit of chewing betel quids and an increasing number are adolescents (32) . This habit has resulted in an increase in the incidence of oral carcinoma (33) and OSF (34) . Although the etiology of OSF remains unclear, evidence has shown that it is a collagen disorder related to betel quid exposure (14, 15, 16, 17 , 22) . The obvious bimodal distribution in the betel quid exposure among OSF patients, as shown in Fig. 1⇓ , suggests individual differences in susceptibility to the development of OSF. It is essential to evaluate the OSF risk associated with polymorphisms of collagen-related genes in low- and high-exposure groups separately to examine whether the high-risk genotypes are consistent or not. Because several genes are involved in the metabolism and cross-linking of collagens, it is, therefore, important to evaluate the combined effects of multiple genes as well as the main effect of single genes. To the best of our knowledge, this is the first study to ...
Define hypercatabolism: excessive metabolic breakdown of complex substances (as protein) within the body : catabolism… - hypercatabolism in a sentence
Cardiovascular diseases (CVDs) are considered to be the predominant reason behind death in the world. of AS initiation and development and find out effective realtors for AS administration recently. 1. Launch Cardiovascular illnesses (CVDs) will be the most common reason behind health loss in the home and overseas, by the actual fact that a lot more than 13 million sufferers expire from CVDs yearly [1]. It is shown that atherosclerosis (AS) is the pivotal pathological basis of CVDs. AS, characterized by formation of atherosclerotic plaques in the KW-6002 inhibition artery intima, could induce lumen stenosis or occlusion, finally leading to the event of CVDs [2]. Thus, in order to reduce the prevalence of life-threatening CVDs, especially ischemic heart disease and stroke, the prevention and treatment of AS are of vital importance. Over the past years, several medicines have been developed as therapeutic providers for While and the representative one is the statin. However, there is evidence ...
Collagenous colitis is a type of IBD where a thick band of collagen develops under the lining of the colon. Learn about the treatment, including diet.
I have recently been diagnosed with collagenous colitis. Symptoms have been severe, chronic diarrea, bowel incontinence at night, abdominal pain, etc. I had a flexsig and a colonoscopy, both confirmi...
1. INTRODUCTION Most people assume that wellness, which actually entails taking care of ourselves, indicates the absence of illness. In recent years, a drastic change has been experienced in the lifestyle of people worldwide in reference to the shift in their gastronomic patterns from consuming healthy to street foods and transitioning from fit to fat. This habit has increased the risk of many maladies, chief among which are cardiovascular diseases (CVDs).. With the loss of an estimated 17.9 million lives per year, CVDs are the primary cause of death globally. The menace of CVDs remains escalating, with more than 75% of these deaths occurring in developing countries [1]. CVD does not connote a single disease, but it is an illness that includes all the issues related to the heart and blood vessels of an individual. Some of the diseases under the umbrella of CVDs include arrhythmias and congestive heart failure. Although there are several approaches to detect these types of disease, the most ...
Sections of left pleural biopsies show fragments of pleural tissue that exhibits focal areas of dense hypocellular fibrosis consistent with a fibrous plaque. Adjoining to the plaque are hyperactive cellular areas that exhibit atypical cellular proliferation comprised of mild to moderately pleomorphic atypical cells that are arranged in a disorganized fashion with intervening dense collagen bands and scattered small mature lymphocytes. The cells are spindled to ovoid have indistinct cell borders and lightly basophilic cytoplasm. At one end of the fragment a group of cells exhibit tubular papillary configuration thus exhibiting biphasic morphology of sarcomatoid and epithelioid. A focal area of necrosis is also identified.. Immunohistochemical stains performed (in addition to those shown) show the following results:. ...
Key takeaways: - What are the causes/reasons behind the increase in the CVDs? - What precautions can be taken to control CVDs in order to reduce deaths and ..
Vascular Disorders. Vascular disorders of the upper-extremity are uncommon, but ones that may have lasting implications.. Anatomy. Arteries bring oxygenated blood from the heart to the fingertips and veins return the used blood back to the heart and lungs. At the level of the wrist 2 major arteries bring blood into the hand: the radial and ulnar arteries (see Figure 1). Variations in the anatomy are common, though, which may affect the way blood flow ultimately reaches each finger.. Causes. There are many causes of vascular problems. They can be classified into 5 groups: traumatic, compressive, occlusive, tumors/malformations and vasospastic (spasm of the artery, which reduces its diameter and thus its blood flow). Vascular problems may occur more commonly in individuals with certain diseases such as diabetes, hypertension, or kidney failure, or in dialysis patients. Occupational exposure (vibrating tools, cold) can be a factor, and smoking also can aggravate and cause vascular ...
A secondary analysis of the TECOS trial affirms sitagliptin does not increase heart failure risk for patients with type 2 diabetes.
Perforating disorders are characterized by transepidermal elimination of altered keratin or dermal connective tissue material. These disorders include perforating folliculitis (as shown below), Kyrle disease, elastosis perforans serpiginosa, reactive perforating collagenosis, and acquired perforating dermatosis.
Collagen is a a fibrous protein found in skin, bone, cartilage, tendon, and other connective tissues throughout the body. Collagen is very important to the structure of the skin. In the skin it is found in the dermis layer and it is what gives the...
A middle layer of tissue in a developing animal embryo which will eventually become the muscles and other connective tissues, the blood vessels and bloo...
ICD-9 code 365.63 for Glaucoma associated with vascular disorders of eye is a medical classification as listed by WHO under the range - DISORDERS OF T
A type 2 excludes note represents not included here. A type 2 excludes note indicates that the condition excluded is not part of the condition it is excluded from but a patient may have both conditions at the same time. When a type 2 excludes note appears under a code it is acceptable to use both the code (C49) and the excluded code together ...
A new approach for generating large numbers of circulatory system cells, known as vascular endothelial cells (VECs), from human amniotic-fluid-derived cells
[ after my firend had the feeding tube from her throat removed and then inserted to her stomach - aprocedure they did through the mouth then out of the stomach- she has since developed e coli.
Kuivaniemi H, Tromp G, Prockop DJ (April 1991). "Mutations in collagen genes: causes of rare and some common diseases in humans ... The active osteoblast produces substantial collagen type I. About 10% of the bone matrix is collagen with the balance mineral. ... Thus, the collagen and mineral together are a composite material with excellent tensile and compressive strength, which can ... Defects in collagen type I cause the commonest inherited disorder of bone, called osteogenesis imperfecta. Minor, but important ...
Collagen disease. COL1:. *Osteogenesis imperfecta. *Ehlers-Danlos syndrome, types 1, 2, 7 ... Diseases of myoneural junction and muscle / neuromuscular disease (G70-G73, 358-359) ... Okada M et al (2007) Primary collagen VI deficiency is the second most common congenital muscular dystrophy in Japan. Neurolog ... The onset of this disease can begin even before birth but is more commonly in childhood or later into adult life. The ...
Collagen disease. COL1:. *Osteogenesis imperfecta. *Ehlers-Danlos syndrome, types 1, 2, 7 ... James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders ... Congenital malformations and deformations of integument / skin disease (Q80-Q82, 757.0-757.3) ...
Collagen disease. COL1:. *Osteogenesis imperfecta. *Ehlers-Danlos syndrome, types 1, 2, 7 ... "OMIM Entry - *113811 - COLLAGEN, TYPE XVII, ALPHA-1; COL17A1".. [permanent dead link] ... Oral lesions are present in a minority of cases.[2] The disease may be acute, but typically will wax and wane. Several other ... Bullous pemphigoid is an acute or chronic autoimmune skin disease, involving the formation of blisters, more appropriately ...
Collagen disease. COL1:. *Osteogenesis imperfecta. *Ehlers-Danlos syndrome, types 1, 2, 7 ...
Collagen disease. COL1:. *Osteogenesis imperfecta. *Ehlers-Danlos syndrome, types 1, 2, 7 ... sickle-cell disease, Tay-Sachs disease, Niemann-Pick disease, spinal muscular atrophy, and Roberts syndrome. Certain other ... Genetic and Rare Diseases Information Center (GARD) Office of Rare Diseases (ORD), National Institutes of Health (NIH) ... Over 6000 human diseases are caused by single-gene defects.[4] Single-gene disorders can be passed on to subsequent generations ...
Such as juvenile diabetes mellitus, antiphospholipid antibody-associated clotting disorders, collagen-vascular disease, and ...
"Endogenous relaxin regulates collagen deposition in an animal model of allergic airway disease". Endocrinology. 147 (2): 754-61 ... Relaxin may affect collagen metabolism, inhibiting collagen synthesis and enhancing its breakdown by increasing matrix ... Relaxin has been shown to reduce cardiac fibrosis in animal models by inhibiting cardiac fibroblasts secreting collagen and ... "Relaxin receptors-new drug targets for multiple disease states". Current Drug Targets. 8 (1): 91-104. doi:10.2174/ ...
Collagen vascular diseases (e.g. systemic lupus erythematosus). *Dehydration. *Glomerular diseases, such as membranous ... The 2005 UK Chronic Kidney Disease guidelines state that protein/creatinine ratio is a better test than 24-hour urinary protein ... Proteinuria secondary to autoimmune disease should be treated with steroids or steroid-sparing agent plus the use of ACE ... Chou JY, Matern D, Mansfield BC, Chen YT (2002). "Type 1 Glycogen Storage Diseases: Disorders of the Glucose-6-Phosphatase ...
In most cases it is observed that the disease involves an overproduction of collagen. Diagnosis is by skin tests. Typically, ... Scleromyositis, is an autoimmune disease (a disease in which the immune system attacks the body). People with scleromyositis ... Although it is a rare disease, it is one of the more common overlap syndromes seen in scleroderma patients, together with MCTD ... Dermatomyositis: an inflammatory disease of skin and muscle marked especially by muscular weakness and skin rash. Scleroderma ...
... is an inherited disease affecting laminin and collagen. This disease is characterised by blister formation within the lamina ... In a survey of 11 families affected by the disease, lack of awareness of the disease by both the public and health care ... DEB is caused by genetic defects (or mutations) within the human COL7A1 gene encoding the protein type VII collagen (collagen ... Epidermis bullosa pruriginosa and albopapuloid epidermolysis bullosa (Pasini's disease) are rare subtypes of this disease. The ...
Other causes include vasculitis, polycythemia, sickle cell disease, decompression sickness, and collagen and elastin disorders ...
Another suggested disease mechanism is that the stress state within collagen fibrils is altered at the locations of mutations, ... Brittle bone disease,[1] Lobstein syndrome,[2] fragilitas ossium,[1] Vrolik disease,[1] osteopsathyrosis, Porak disease, ... If the body does not destroy the improper collagen, the relationship between the collagen fibrils and hydroxyapatite crystals ... Diseases related to gastrointestinal are celiac disease, gluten sensitivity, and colitis. The acute pain experienced by ...
Until quite late in the disease the damage is reversible, as healthy collagen replaces the defective collagen with vitamin C ... Scurvy is a disease resulting from a deficiency of vitamin C, since without this vitamin, collagen made by the body is too ... Other diseases[edit]. Studies examining the effects of vitamin C intake on the risk of Alzheimer's disease have reached ... Prockop DJ, Kivirikko KI (1995). "Collagens: molecular biology, diseases, and potentials for therapy". Annual Review of ...
Prockop's research as a biochemist has focused on collagen and connective tissue diseases such as osteogenesis imperfecta and ...
... a disease of pathological collagen production and deposition in the hands. This disease causes flexion contractures of the ... Beta-toxin plays a major role in the pathogenicity of C. histolyticum, due to its ability to destroy collagen fibers in the ... It is not active against collagen. The molecular weight of gamma-toxin is 50,000 Da. Delta- toxin is an elastase activated by ... A 2002 study of the intestinal flora of inflammatory bowel disease (IBD) patients found that in patients who had ulcerative ...
... and collagen diseases. Megaduodenum can be passed down through families, it occurs when a patient inherits one copy of a muted ... Megaduodenum is an uncommon disease, and because of its extreme rarity of the condition only few cases has been reported in the ... Jones, S. C.; Dixon, M. F.; Lintott, D. J.; Axon, A. T. R. (1992-03-01). "Familial visceral myopathy". Digestive Diseases and ... It is possible that this disease can be misdiagnosed and mimic other intestinal disorders, or later increase the chances of ...
... collagen vascular disease, and hyperparathyroidism. LearningRadiology.com > Coarctation Of the Aorta Retrieved August 2010 " ...
... collagen vascular disease and cytotoxic drugs and diabetes mellitus. A preexisting infection caused by aerobic or facultative ... Reviews of Infectious Disease. 13: 819-822; 1991. Finegold SM. Anaerobic bacteria in human disease. Orlando: Academic Press Inc ... "Pelvic Inflammatory Disease - CDC Fact Sheet". www.cdc.gov. November 19, 2020. Barrett S, Taylor C..A review on pelvic ... Pelvic inflammatory disease. Obstet Gynecol. 2010; 116(2 Pt 1):419-28. Donders G. Diagnosis and management of bacterial ...
Systemic sclerosis and collagen vascular diseases. *Short bowel syndrome. Due to surgical structural changes *Gastrectomy; ... OGD to detect duodenal pathology and obtain D2 biopsy (for coeliac disease, tropical sprue, Whipple's disease, ... Newnham ED (2017). "Coeliac disease in the 21st century: paradigm shifts in the modern age". J Gastroenterol Hepatol (Review). ... Whipple's disease: Alcian blue with apparently eosin counterstain enlarged villus with many macrophages. ...
Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Biochem. 1995, 64: 403-34. PMID 7574488. doi: ... 膠原(Collagen)是一種蛋白質,它存在人體的結締組織、血管和骨骼的組織及牙本質細胞之間,是動物體型的基本支撐物質。所以它可以使細胞排列緊密,皮膚緊緻,骨骼牙齒堅固。當受到外傷時或是手術後它可以幫助細胞修復、促進傷口的癒合。[66][67][68] ... Prockop DJ, Kivirikko KI: Collagens: molecular
Meningitis, encephalitis (inflammation of the brain tissue), Lyme disease, collagen vascular disease. A stiff neck, or ... Arteriovenous malformation, collagen vascular disease, intracranial mass lesion. Focal neurological signs indicate something is ... Neuroimaging, blood tests for collagen vascular diseases Change in personality, consciousness, or mental status. Central ... non-infectious inflammatory disease, intracranial neoplasm, epileptic seizure or other types of disorders or diseases that are ...
Diverticular disease is more common in collagen disorders such as Ehlers Danlos Syndrome.[25] ... Cleave TL 1974 The Saccharine disease Wright Bristol *^ Painter NS (1975) Diverticular disease of the colon. Heinemann Medical ... Comparato G, Pilotto A, Franzè A, Franceschi M, Di Mario F (2007). "Diverticular disease in the elderly". Digestive Diseases. ... "Clinical manifestations and diagnosis of colonic diverticular disease". Literature review.. *^ Stefánsson T, Ekbom A, Sparèn P ...
This is due to the fact that collagen makes up about 25-35% of the protein in our bodies and contains a hydroxyproline at ... which can manifest itself as the disease scurvy. Since citrus fruits are rich in vitamin C, British sailors were given limes to ... Collagen consists of both 3‐hydroxyproline and 4‐hydroxyproline residues. Hydroxylation occurs at the γ-C atom, forming ... Deprivation of ascorbate leads to deficiencies in proline hydroxylation, which leads to less stable collagen, ...
... and collagen vascular disease as related to the central nervous system. Schievink is also an expert and well published author ...
Clinical application of D-glucosamine and scale collagen peptide on canine and feline orthopedic diseases and spondylitis ... a degenerative disease of the pancreas. It is estimated that 1% of the UK GSD population suffers from this disease.[65] ... "Von Willebrand's Disease (vWD): A Type of Hemophilia in Dogs". Drs. Foster & Smith, Inc. Retrieved 10 May 2009.. ... Additionally, German Shepherds have a higher than normal incidence of Von Willebrand disease, a common inherited bleeding ...
CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis. „Arthritis Rheum". 48 (5), s. 1452-1460 ... Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of ... OX-22high CD4+ T cells induce wasting disease with multiple organ pathology: prevention by the OX-22low subset. „J Exp Med". ... CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease. „J Exp Med". 196 (3), s. 401-406, ...
It rises in response to allergies, parasitic infections, collagen diseases, and disease of the spleen and central nervous ... Chronic inflammation - especially juvenile rheumatoid arthritis, rheumatoid arthritis, Still's disease, Crohn's disease, ... Infectious diseases - viral (AIDS, SARS, West Nile encephalitis, hepatitis, herpes, measles, others), bacterial (TB, typhoid, ... The number of leukocytes in the blood is often an indicator of disease, and thus the white blood cell count is an important ...
Diseases involving basement membranes at multiple locations include: Genetic defects in the collagen fibers of the basement ... collagen VII (anchoring fibrils) fibrillin (microfibrils) Lamina reticularis collagen III (as reticular fibers) Connective ... of autoantibodies in the autoimmune disease Goodpasture's syndrome. A group of diseases stemming from improper function of ... Some diseases result from a poorly functioning basement membrane. The cause can be genetic defects, injuries by the body's own ...
... granulomatous disease such as tuberculosis or coccidioidomycosis, collagen vascular diseases, and other inflammatory states. ... Diseases of the pleural cavity include: Pneumothorax: a collection of air within the pleural cavity Pleural effusion: a fluid ... Green-brown: Biliary disease, bowel perforation with ascites. Milky-white or yellow and bloody: Chylous effusion. Milky or ... Light, Richard W. (2007). Pleural Diseases. Lippincott Williams & Wilkins. ISBN 978-0781769570. Photo of dissection at kenyon. ...
Spivey KA, Chung I, Banyard J, Adini I, Feldman HA, Zetter BR (October 2011). "A role for collagen XXIII in cancer cell ... MacDonald BT, Tamai K, He X (July 2009). "Wnt/β-catenin signaling: components, mechanisms, and diseases". Dev. Cell. 17 (1): 9- ... For instance, higher levels of collagen XXIII have been associated with higher levels of catenins in cells. These heightened ... levels of collagen helped facilitate adhesions and anchorage-independent cell growth and provided evidence of collagen XXIII's ...
Rosenbloom J (1984). «Elastin: relation of protein and gene structure to disease». Lab. Invest. 51 (6): 605-23. PMID 6150137. ... Tzaphlidou M (2004). «The role of collagen and elastin in aged skin: an image processing approach». Micron. 35 (3): 173-7. PMID ... 2009). «Association of genetic variants with chronic kidney disease in individuals with different lipid profiles». Int. J. Mol ... 2010). «Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease». Gastroenterology. 139 (1): ...
Pests and diseases[edit]. The sweet pea plant does suffer from some pests, the most common being aphids. These insects suck the ... Seeds of the sweet pea contain beta-aminopropionitrile that prevents the cross-linking of collagen by inhibiting lysyl oxidase ... The main effect is thought to be on the formation of collagen. Symptoms are similar to those of scurvy and copper deficiency, ... which share the common feature of inhibiting proper formation of collagen fibrils. ...
This article is about a skin disease common during adolescence. For other acneiform skin diseases, see Acne (disambiguation). ... microspheres with collagen; human and bovine collagen derivatives, and fat harvested from the person's own body (autologous fat ... Disease Primers. 1: 15033. doi:10.1038/nrdp.2015.33. PMID 27227877.. *^ a b "Frequently Asked Questions: Acne" (PDF). U.S. ... Acne, also known as acne vulgaris, is a long-term skin disease that occurs when dead skin cells and oil from the skin clog hair ...
Coccidians in the genus Aggregata living in the gut cause severe disease to the host. Octopuses have an innate immune system, ... and a connective tissue dermis consisting largely of collagen fibres and various cells allowing colour change.[22] Most of the ... The diseases and parasites that affect octopuses have been little studied, but cephalopods are known to be the intermediate or ...
The results of this research was used as a model for Kashin-Beck disease. Kashin-Beck is a result of combinatorial ... The disease has symptoms similar to those resulting from Trsp gene knockout.[12] ... a putative model for Kashin-Beck disease". PLOS Genet. 5 (8): e1000616. doi:10.1371/journal.pgen.1000616. PMC 2721633. PMID ... COL2A1 collagen disease. *Achondrogenesis *type 2. *Hypochondrogenesis. SLC26A2 sulfation defect. *Achondrogenesis *type 1B ...
"Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen" ... Mixed connective tissue disease - a disease of the autoimmune system, also undifferentiated connective tissue disease. ... groups of adipose cells are kept together by collagen fibers and collagen sheets in order to keep fat tissue under compression ... Type I collagen is present in many forms of connective tissue, and makes up about 25% of the total protein content of the ...
Enamel hypoplasias generally form due to disease and/or poor nutrition. Linear furrows are commonly referred to as linear ... Nitrogen isotopes in bone collagen are ultimately derived from dietary protein, while carbon can be contributed by protein, ... For example, bioarchaeologists have used caries in skeletons to correlate a diet of rice and agriculture with the disease. ... Disruptions in homeostasis caused by nutritional deficiency or disease or profound inactivity/disuse/disability can lead to ...
Possibly important to basement membrane architecture and tissue development, as a needed catalyst to make collagen IV.[37] ... Authors: Nielsen, Forrest H. USDA, ARS Source: Modern nutrition in health and disease / editors, Maurice E. Shils ... et al.. ... Interrelations between Essential Metal Ions and Human Diseases. Springer Science & Business Media. p. 349. ISBN 978-94-007-7500 ... "Bromine Is an Essential Trace Element for Assembly of Collagen IV Scaffolds in Tissue Development and Architecture". Cell. 157 ...
It is based on the microfracture surgery with the application of a bi-layer collagen I/III membrane. The AMIC technique was ... "Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells ... The collagen membrane protects and stabilizes the MSCs released through microfracture and enhances their chondrogenic ... "Maci" or autologous cultured chondrocytes on porcine collagen membrane, is a treatment to correct cartilage defects in the knee ...
... coronary heart disease, dimension, osteoporosis, eye disease, stroke cancer and rheumatoid arthritis and the influence of ... Foundation for strong healthy bones and teeth - majority of the calcium consumed as a child is deposited onto collagen bone ... The Centers for Disease Control and Prevention (2014). Children eating more fruit, but fruit and vegetable intake still too low ... Development of chronic disease has become closely related to the consumption of fruits and vegetables throughout childhood ( ...
2008) Agricultural lung diseases. Environ Health Perspect 108:705-12. Hlastala MP, Ralph DD, Babb AL, Influence of gas physical ... Mice that survive this initial onslaught go on to demonstrate an increase in lung collagen content, and decreased lung ... Secondary effects of sulfur mustard exposure lead to chronic lung diseases such as chronic bronchitis. A common exposure ... 2011) Sarcoid like granulomatous pulmonary disease in World Trade Center disaster responders. Am J Ind Med. 54:175-84. Banauch ...
Role in disease[edit]. Mutations in the first SOD enzyme (SOD1) can cause familial amyotrophic lateral sclerosis (ALS, a form ... insights into heparin and collagen binding". J. Mol. Biol. 388 (2): 310-26. doi:10.1016/j.jmb.2009.03.026. PMID 19289127.. ... This was cut short by concerns about prion disease.[citation needed] An SOD-mimetic agent, TEMPOL, is currently in clinical ... The other two isoforms of SOD have not been linked to many human diseases, however, in mice inactivation of SOD2 causes ...
... is one such disease, part of an emerging class of diseases called ciliopathies. The underlying cause ... "Genes and Diseases. NCBI. 1998. Retrieved November 8, 2010.. *^ Ruiz-Perez VL, Ide SE, Strom TM, et al. (2000). "Mutations in a ... Observation of the inheritance pattern has illustrated that the disease is autosomal recessive, meaning that both parents have ... Known ciliopathies include primary ciliary dyskinesia, Bardet-Biedl syndrome, polycystic kidney and liver disease, ...
Mitochondria is involved in Parkinson's disease. In idiopathic Parkinson's disease, the disease is commonly caused by ... Another study demonstrated that skeletal muscle fibres of collagen VI knockout mice showed signs of degeneration due to an ... Parkinson disease[edit]. Parkinson disease is a neurodegenerative disorder partially caused by the cell death of brain and ... "Autophagy in Stress, Development & Disease, 2003, Gordon Research Conference".. *^ "Autophagy in Health and Disease (Z3), 2007 ...
Kumar, Vinay (2010). Robbins and Coltran Pathologic Basis of Disease. China: Elsevier. pp. 88-89. ISBN 978-1-4160-3121-5. .. ... The addition of PDGF at specific time‐points has been shown to stabilise vasculature in collagen‐glycosaminoglycan scaffolds.[ ... Like many other growth factors that have been linked to disease, PDGF and its receptors have provided a market for receptor ... The patch employs a collagen platform seeded with particles containing the genes needed for producing bone. In experiments, it ...
Integrin ligands (collagens, fibrinogen, fibronectin, laminins, ICAM-1, ICAM-2, osteopontin, VCAM-1, vitronectin) ... Overactivation of bradykinin is thought to play a role in a rare disease called hereditary angioedema, formerly known as ...
Dysregulation of TNF production has been implicated in a variety of human diseases including Alzheimer's disease,[6] cancer,[7] ... Tumor necrosis factor (TNF) alpha increases collagen accuulation and proliferation in intestinal myofibrobasts via TNF Receptor ... Clark IA (June-August 2007). "How TNF was recognized as a key mechanism of disease". Cytokine Growth Factor Rev. 18 (3-4): 335- ... These concepts were extended to systemic disease in 1981, when Ian A. Clark, from the Australian National University, in ...
Serum Collagen IV concentrations correlate with hepatic tissue levels of collagen IV in subjects with alcoholic liver disease ... Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C- ... Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen".[citation needed] Collagen IV ... Also, collagen IV lacks the regular glycine in every third residue necessary for the tight, collagen helix. This makes the ...
Evidence for combined transepidermal elimination of both collagen and elastic fibers. Arch Dermatol. 1989 Aug. 125(8):1074-8. " ... and renal disease to help bolster the diagnosis of Kyrle disease. Other underlying diseases that Kyrle disease is observed with ... Kyrle disease is a rare disease unless there is a high count of patients with chronic renal failure. The disease seems to be ... Due to the causes of Kyrle disease is unknown, the best way to prevent the disease is to prevent the disorders that are usually ...
Neidhart, M (2016). DNA Methylation and Complex Human Disease (1st ed.). San Diego: Academic Press. p. 22.. ISBN 978-0124201941 ... Integrin ligands (collagens, fibrinogen, fibronectin, laminins, ICAM-1, ICAM-2, osteopontin, VCAM-1, vitronectin) ... Neidhart, M (2016). DNA Methylation and Complex Human Disease (1st ed.). San Diego: Academic Press. p. 222.. ISBN 9780124201941 ... suggests that therapeutic strategies that enhance IGF2 signalling and adult neurogenesis might be suitable to treat diseases ...
... mutations or other genetic defects can lead to severe diseases. Instances are collagen[3] family of proteins, tendon, muscle ... Saad, Mohamed (Oct 1994). Low resolution structure and packing investigations of collagen crystalline domains in tendon using ...
... (CGPD), is a rare benign granulomatous skin disease of unknown cause.[1] The ... After CGPD resolves, the skin may return to normal without scarring or may have small atrophic depressions with collagen loss, ... CGPD is known to be a temporary skin disease with a benign course.[1] The skin papules typically resolve after a few months to ... CGPD occurs most often in children of Afro-Caribbean descent before puberty though reports of this disease occurring in Asian ...
Disease. Target antigen. Effects. Allergic contact dermatitis[1]. Environmental chemicals, like urushiol (from poison ivy and ... Possibly collagen and/or citrullinated self proteins. Chronic arthritis, inflammation, destruction of articular cartilage and ... Inflammatory bowel disease[1]. Enteric microbiota and/or self antigens. Hyperactivation of T-cells, cytokine release, ... Various, depending on underlying disease. Walled off lesion containing macrophages and other cells. ...
... inflammatory bowel disease, diabetes and chronic heart disease. The Celiac Disease Foundation points out that a gluten-free ... Collagen cross-linking by applying riboflavin topically then shining UV light is a method to slow progression of corneal ... "Collagen cross-linking: when and how? A review of the state of the art of the technique and new perspectives". Eye and vision ... chronic alcoholism and in diseases such as HIV, ...
Significant diseases. പ്രമേഹം, Thyroid disease, Androgen excess. Significant tests. Thyroid function tests, Blood sugar levels ... അവ കൊളാജൻ (collagen),[40] മ്യൂക്കോപ്രോട്ടീൻ മാട്രിക്സ് (matrix)[41] എന്നിവയുടെ ശിഥിലീകരണത്തെ പ്രോത്സാഹിപ്പിക്കുന്നു. കിഡ്നി ...
"Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease". New England Journal Medicine. Retrieved 5 December ... Platelet activation (through agonists such as thrombin, Type II collagen and ADP) results in "membrane flipping" where the ...
... see autoimmune disease; collagen. Source for information on collagen disease: The Columbia Encyclopedia, 6th ed. dictionary. ... Deficiency Disease , Skip to main content deficiency disease Tay-sachs Disease , Tay-Sachs Disease TAY-SACHS DISEASE (Amaurotic ... death an… Lou Gehrigs Disease , Lou Gehrigs Disease Definition Lou Gehrigs disease, or amyotrophic lateral sclerosis (ALS), ... nósos disease; see -LOGY. nosology (nos-ol-ŏji) n. the naming and classification of diseases. ...
Diseases of the spine.. Soft-tissue rheumatism and related disorders.. Regional arthrological and musculoskeletal syndromes. ... Treatment-induced and associated conditions and diseases.. Integrated diagnostic screening program staged diagnostics. ...
Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease ... Download PDF Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. Item availability ... Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. Matrix Biology, 29(5):346-56. ... Loss of DDR1-expression in the kidney delayed renal fibrosis and inflammation in hereditary type IV collagen disease. This ...
The Interstitial Lung Disease Patterns Seen in Various Collagen Vascular Diseases. As with all ILD, the signs and symptoms of ... Beware: there are other diseases that can mimic pulmonary complications of collagen vascular diseases:. Secondary infections, ... Beware: there are other diseases that can mimic pulmonary complications of collagen vascular diseases: ... Are you sure your patient has a pulmonary complication of a collagen vascular disease? What should you expect to find? * ...
Collagen Diseases R96 Predesigned 96-well panel for use with SYBR® Green ... Collagen Diseases R384 Predesigned 384-well panel for use with SYBR® Green ... Collagen diseases M96 Predesigned 96-well panel for use with SYBR® Green ... Collagen diseases M384 Predesigned 384-well panel for use with SYBR® Green ...
Find out information about Collagen-vascular disease. see autoimmune disease autoimmune disease, any of a number of abnormal ... redirected from Collagen-vascular disease). Also found in: Medical. collagen disease:. see autoimmune diseaseautoimmune disease ... Collagen-vascular disease , Article about Collagen-vascular disease by The Free Dictionary https://encyclopedia2. ... a href=https://encyclopedia2.thefreedictionary.com/Collagen-vascular+disease,collagen disease,/a,. *Facebook ...
Is swollen bulging eye and pain behind the ear a symptom of connective tissue disease and autoimmune thyroid ?. Ask a Doctor ... I have a past history of collagen vascular disease and leukopenia. ... I have a past history of collagen vascular disease and leukopenia. Is swollen bulging eye and pain behind the ear a symptom of ... Twenty years ago I was told I had collegen vascular disease and had steroid shots and prednisone. Have used Celebrex in the ...
List of 35 causes for Collagen vascular diseases causing fever and Gerd-like chest pain and Severe heartburn after eating, ... Vascular diseases *Collagen *Collagen diseases *Collagen disorder *Vascular *Vascular disease *Vascular disorder *Fever (2274 ... Collagen vascular diseases causing fever *Introduction: Collagen vascular diseases causing fever *Collagen vascular diseases ... More Searches: Collagen vascular diseases causing fever. *Collagen vascular diseases causing fever: Add a 4th symptom *Collagen ...
Diet for collagen diseases. Will diet for collagen diseases plan. No URL redirects. A no cost work from home alternative as ... In the event diet for collagen diseases can learn to pace up your metabolism, your physiques diet for collagen diseases will ... In time the toddlers physique adjusts to diet for collagen diseases meals a day diet for collagen diseases its then thought- ... Its higher to have apple fasting day significantly after diet for collagen diseases or for many who broke your weight loss ...
Collagen vascular disease and pregnancy. Collagen vascular disease and pregnancy the. Nonetheless, due to limited space we do ... Click right here coklagen read extra about our work collagen vascular disease and pregnancy the impression we gascular collagen ... Hughes E, Collins J, Vandekerckhove P. Some ladies resolve to hire a collagen vascular disease and pregnancy to assist help ... Collahen involuntary leaking could occur when coughing, sneezing and collagen vascular disease and pregnancy laughing. As ...
Collagen vascular disease comes in a group of diseases called autoimmune disorders, wherein the immune system in the body ... Order Soma Online Overnight for Relieving Collagen Vascular Disease (CVD). usa2019-11-12T05:22:56+00:00 By usa Health Buy Soma ... Signs of Collagen Vascular Disease. Changes in the skin could be the initial visible symptoms of CVD and can be useful in ... To relieve collagen vascular disease in an ideal manner, order Soma online overnight, a strong muscle relaxer used to heal ...
Injectable Homone from Injectable Polypeptide Hormones Corticotropin Muscle Building and Collagen Diseases - Wuhan Yuancheng ... China Injectable Polypeptide Hormones Corticotropin Muscle Building and Collagen Diseases, Find details about China Muscle ... 99% Injectable Polypeptide Hormones Corticotropin CAS 9002-60-2 ACTH For Muscle Building & Collagen Diseases. 1. ... lupus and other collagen diseases. Clinical use of cortisone similar.. 2.Description: ...
Collagen-vascular diseases; systemic lupus erythematosus, acute dermatomyositis-polymyositis, progressive systemic sclerosis, ... Collagen-vascular diseases; systemic lupus erythematosus, acute dermatomyositis-polymyositis, progressive systemic sclerosis, ... stichtingdoel.com - Collagen-vascular diseases; systemic lupus erythematosus, acute dermatomyositis-polymyositis, progressive ... 4 edition of Collagen-vascular diseases; systemic lupus erythematosus, acute dermatomyositis-polymyositis, progressive systemic ...
Lyme disease, rare hereditary disorders, and AIDS so, although blood tests are highly recommended th... ... Neurologic symptoms similar with those in multiple sclerosis appear in collagen-vascular diseases, ... Neurologic symptoms similar with those in multiple sclerosis appear in collagen-vascular diseases, Lyme disease, rare ... With the aid of an appropriate course of treatment, the progression of the disease can be slowed down and patients with ...
All patients in the ONTT had blood testing to exclude collagen vascular disease (antinuclear antibody), syphilis (FTA-ABS), and ... Of these patients, only one developed a connective tissue disease in the first two years of follow up. FTA-ABS was positive in ... 2. Brewis M, Poskanzer DC, Rolland C, et al: Neurological disease in an English city. Acta Neurol Scand 42 (Suppl 24):1, 1965. ... and no systemic disease other than multiple sclerosis that might be associated with optic neuritis.(13). ...
Some of these diseases are similar to each other. They may involve arthritis and inflammation of ... In a class of diseases known as autoimmune disorders, the bodys immune system attacks its own tissues. ... People who developed these disorders were previously said to have "connective tissue" or "collagen vascular" disease. We now ... In a class of diseases known as autoimmune disorders, the bodys immune system attacks its own tissues. Some of these diseases ...
The pathophysiology of wound healing in the bowel wall suggests that collagen and matrix metalloproteinases (MMPs) have an ... Extracellular matrix Bowel disease MMPs Anastomotic leakage Diverticular diseases Crohns disease This is a preview of ... Seromarkers of collagen I and III metabolism in active Crohns disease. Relation to disease activity and response to therapy. ... Alexander AC, Irving MH (1990) Accumulation and pepsin solubility of collagens in the bowel of patients with Crohns disease. ...
Collagen-vascular diseases have been found in 0.6-2% of patients with alopecia areata, while the incidence in control subjects ... Drugs & Diseases , Dermatology , Alopecia Areata Q&A What is the prevalence of collagen-vascular diseases in alopecia areata?. ... What is the prevalence of collagen-vascular diseases in alopecia areata?) and What is the prevalence of collagen-vascular ... Collagen-vascular diseases have been found in 0.6-2% of patients with alopecia areata, while the incidence in control subjects ...
Lupus, rheumatoid arthritis, and scleroderma are all types of collagen vascular disease. ... Collagen vascular disease. "Collagen vascular disease" is the name of a group of diseases that affect your connective tissue. ... Causes of collagen vascular disease. Collagen vascular disease is an autoimmune disease. This means that your immune system ... Collagen vascular disease is sometimes also called connective tissue disease. Collagen vascular diseases can be heritable ( ...
Pharmacokinetics (PK) of Esomeprazole: Area Under the Concentration-Time Curve From the Time of Dosing to the Last Measurable Concentration (AUC[0-t ...
Allergies & Asthma Alzheimers Disease Anxiety & Panic Disorders Arthritis Breast Cancer Chronic Fatigue Crohns Disease Cystic ... Lyme Disease Multiple Sclerosis Parkinsons Disease Prostate Cancer ... I cant take collagen. It brings on shingles for me. Same with bone broth. High in arginine. Arginine is in Buhners bart ... Anxiety & Panic Disorders Bipolar Disorder Breast Cancer Chronic Pain Crohns Disease Depression Diabetes Fibromyalgia GERD & ...
Increased collagen VI levels during development mainly result in slower migration of eNCCs. This appears to be due to the fact ... Hirschsprungs disease (HSCR) is a severe congenital anomaly of the enteric nervous system (ENS) characterized by functional ... expression that increases total collagen VI protein levels in the extracellular matrix (ECM) surrounding both the developing ... that contains an untargeted transgenic insertion upstream of the collagen-6α4 (. Col6a4. ) gene. This insertion induces eNCC- ...
Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.. R O Williams, M Feldmann, and R N ... Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. ... Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. ... Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. ...
Comprehensive disease interaction information for aloe vera/collagen/lidocaine/sodium hyaluronate topical. Includes Lidocaine ... There are 5 disease interactions with aloe vera / collagen / lidocaine / sodium hyaluronate topical:. Major Lidocaine (Includes ... Aloe vera / collagen / lidocaine / sodium hyaluronate topical Rating. No Reviews - Be the first! ... aloe vera / collagen / lidocaine / sodium hyaluronate topical drug Interactions. There are 6 drug interactions with aloe vera ...
Collagen-vascular diseases (CVDs) are a heterogeneous group of autoimmune disorders characterized by the presence of ... Interstitial Lung Disease Associated With Collagen-Vascular Disease) and Interstitial Lung Disease Associated With Collagen- ... Interstitial Lung Disease Associated With Collagen-Vascular Disease * Sections Interstitial Lung Disease Associated With ... Collagen vascular disease-related lung disease: high-resolution computed tomography findings based on the pathologic ...
Tag: Collagen. Supplements Best Collagen Supplements - January, 2020 Reviews & Buyers Guide. That decrease can lead to ...
A combination gene-and-cell therapy has given a boy with a grievous skin disease a new lease on life, and has resolved a ... Boosting levels of a the immunosuppressive protein PD-L1 in blood stem cells halts diabetes in a mouse model of the disease. ... Infectious protein aggregates from the skin of human patients can cause disease in mice. ... tags: collagen x disease/medicine x The Scientist. » collagen and disease/medicine ...
... often autoimmune diseases affecting connective tissue, including lupus erythematosus, rheumatoid arthritis, and scleroderma. ... often autoimmune diseases affecting connective tissue, including lupus erythematosus, rheumatoid arthritis, and scleroderma. ... collagen vascular disease definition: nounAny of a group of inflammatory, ... collagen vascular disease definition: nounAny of a group of inflammatory, ...
The diagnosis of collagen vascular disease should not be made in the absence of corroborative laboratory data. In cases of ... There may be a good response to steroid treatment in cases of suspected but not confirmed collagen vascular disease in which ... Cardiac tumours can mimic collagen vascular disease and they are often accompanied by profound systemic upset. Both benign and ... A review of fifteen similar case reports showed that a spectrum of different collagen vascular diseases was diagnosed and ...
... and indicate cell-type-specific disease mechanisms for collagen diseases. ... Disease Models & Mechanisms 2016 9: 165-176; doi: 10.1242/dmm.021741 Summary: Structural and compositional basement membrane ... ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations ... defects and ER stress due to Col4a1 mutations cause glomerular and tubular kidney disease, ...
Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid arthritis, systemic lupus ... The term "collagen disease" was coined by Dr. Paul Klemperer at Mount Sinai Hospital in New York City in 1941.[1] ... Collagen disease entry in the public domain NCI Dictionary of Cancer Terms ... but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the ...
Soret and colleagues identify a new mechanism that causes HSCR-like disease in mice and involves deposition of excess collagen ... Hirschsprungs disease, Down syndrome, and missing heritability: too much collagen slows migration. ... Hirschsprungs disease, Down syndrome, and missing heritability: too much collagen slows migration. ... Hirschsprungs disease (HSCR) causes functional intestinal obstruction due to the absence of the enteric nervous system (ENS) ...
... collagen disease explanation free. What is collagen disease? Meaning of collagen disease medical term. What does collagen ... Looking for online definition of collagen disease in the Medical Dictionary? ... Related to collagen disease: Scleroderma, Connective tissue disorder. col·la·gen dis·ease. , collagen-vascular disease. a group ... collagen diseases like lupus, dermatologic diseases, ophthalmic diseases, respiratory diseases, gastrointestinal diseases, ...
... of collagen IV mutations disease remain poorly characterized. To provide novel insights into collagen diseases mechanisms, this ... Mutations in the BMs major component collagen IV can cause eye and kidney defects and cerebrovascular disease including ... Engineering biointerfaces to reveal collagen IV disease mechanisms. 8th International Conference on Tissue Science and ... fibronectin and collagen IV. This has enabled to address the hypothesis that biomaterials can alter collagen mutant cells ...
Most musculoskeletal degenerative diseases, including osteoarthritis, spinal stenosis, and degenerative disk disease, involve ... Collagen: Why All the Fuss?. Collagen is a family of highly fibrous proteins found in all animals, and is the most abundant ... The main types of collagen in these tissues are Types I, II, III, V, and IX. Type I is the principle collagen found in skin and ... We were fascinated by collagen and we conducted thorough studies to ensure we had the proper dosage and type of collagen ...
Pauling and Matthias Rath, MD, later completed a 15-year study in which they demonstrated that cancer is a collagen disease ... CANCER-PROOF YOUR COLLAGEN. Collagen is composed of several key nutrients that are only available through diet - your body ... Heres what I did to strengthen my collagen:. • Boost Collagen with Key Supporting Nutrients. The original formula from Pauling ... Modern researchers have continued to look further into the collagen connection to cancer and found that while healthy collagen ...
... PLoS ONE 7(1): e29818. ... Our study reveals that although glycosylation is not required for ligand binding, each of the four disease-associated mutations ... This domain contains four disease-associated mutations and two N-glycosylation sites. ... we have recently demonstrated that collagen III is the ligand of GPR56 in the developing brain. In this report, we discover a ...
Rheumatic pleuritis Collagen vascular diseases are a complex group of systemic inflammatory diseases generally considered ... Collagen vascular diseases are a complex group of systemic inflammatory diseases generally considered autoimmune in etiology. ... McQuitty E., Allen T.C. (2018) Collagen Vascular Disease, Pleural. In: Allen T.C., Suster S. (eds) Pathology of the Pleura and ... Many collagen vascular diseases involve pulmonary parenchyma with resulting significant morbidity (hyperlink). They also ...
Esophageal Function in Collagen Disease. R. Turner, M.D.; W. Lipshutz, M.D.; A. Tuck, M.D.; W. Miller, M.D.; R. Schumacher, M.D ... Turner R, Lipshutz W, Tuck A, Miller W, Schumacher R, Cohen S. Esophageal Function in Collagen Disease.. Ann Intern Med. 1971; ... classical disease as diagnosed by American Rheumatism Association criteria. No patients had dysphagia at the time of evaluation ...
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  • The CVDs most commonly associated with pulmonary complications are systemic lupus erythematosus (SLE), scleroderma, rheumatoid arthritis (RA), mixed connective tissue disease (MCTD), polymyositis/dermatomyositis (PM/DM), and Sjögren's syndrome. (psychiatryadvisor.com)
  • In young people multiple sclerosis occurs with the following symptoms: blurred vision, suddenly double vision and movement problems and abnormal sensations in scattered parts of the body and it may be mistaken with other diseases such as: emotional disorders, chronic fatigue syndrome, Lyme disease. (streetdirectory.com)
  • Neurologic symptoms similar with those in multiple sclerosis appear in collagen-vascular diseases, Lyme disease, rare hereditary disorders, and AIDS so, although blood tests are highly recommended they are not specific for diagnosing multiple sclerosis and differentiating it from other conditions. (streetdirectory.com)
  • AIDS, lupus, arteritis, amyotrophic lateral sclerosis, hereditary ataxias, Guillain-Barr syndrome, Lyme disease syphilis, a cyst in the spinal cord are the diseases with which differential diagnosis must be done so as to clarify the diagnosis of multiple sclerosis. (streetdirectory.com)
  • Patients with BO may also present with more rapidly progressive symptoms than are typically seen in small airways disease. (psychiatryadvisor.com)
  • In RA, the disease tends to correlate with joint symptoms, but it has been described prior to the onset of articular manifestations. (psychiatryadvisor.com)
  • However, the good news is that multiple sclerosis is not a life-threatening disease and that the existing treatments can successfully keep its generated symptoms under control. (streetdirectory.com)
  • The intensity of the symptoms produced by multiple sclerosis and the progression of the disease are strongly influenced by the proportions of the demyelination process and the location of the hardened lesions. (streetdirectory.com)
  • With the aid of an appropriate course of treatment, the progression of the disease can be slowed down and patients with multiple sclerosis can live active, normal lives. (streetdirectory.com)
  • Algorithms for connective tissue disease and vasculitis. (helsinki.fi)
  • Cough and dyspnea on exertion are the most common, and with more advanced disease, hypoxemia with exertion may be identified. (psychiatryadvisor.com)
  • Several collagen vascular diseases, including lupus, scleroderma, and rheumatoid arthritis, are more common in women than in men. (healthline.com)
  • Rheumatoid arthritis affects about 1.3 million adults in the United States, according to the National Institute of Arthritis and Musculoskeletal and Skin Diseases. (healthline.com)
  • This disease model was chosen because of its many immunological and pathological similarities to human rheumatoid arthritis. (pnas.org)
  • They include systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), progressive systemic sclerosis (PSS), dermatomyositis (DM)/polymyositis (PM), ankylosing spondylitis (AS), Sjögren syndrome (SS), and mixed connective-tissue disease (MCTD) . (medscape.com)
  • Any of a group of inflammatory, often autoimmune diseases affecting connective tissue, including lupus erythematosus, rheumatoid arthritis, and scleroderma. (yourdictionary.com)
  • Collagen disease is a term previously used to describe systemic autoimmune diseases (e.g., rheumatoid arthritis , systemic lupus erythematosus , and systemic sclerosis ), but now is thought to be more appropriate for diseases associated with defects in collagen , which is a component of the connective tissue. (wikidoc.org)
  • A term formerly, and erroneously, applied to such conditions as rheumatic fever, ankylosing spondylitis, polyarteritis nodosa, lupus erythematosus, rheumatoid arthritis and dermatomyositis but now applied to those known to be caused by defects in the chemical structure of collagen and its distribution and quantity. (thefreedictionary.com)
  • This disease group includes systemic lupus erythematosus (hyperlink), rheumatoid arthritis (hyperlink), progressive systemic sclerosis (hyperlink), polymyositis/dermatomyositis (hyperlink), Sjögren syndrome (hyperlink), overlap syndromes such as mixed connective tissue disease (hyperlink), undifferentiated connective tissue disease, and others. (springer.com)
  • and rheumatoid arthritis, classical disease as diagnosed by American Rheumatism Association criteria. (annals.org)
  • The condition is often accompanied with other autoimmune diseases such as rheumatoid arthritis and lupus. (tandurust.com)
  • Maintenance of the invasive pannus in rheumatoid arthritis is an integral part of disease progression. (eurekamag.com)
  • Rheumatoid arthritis (RA), a chronic systemic inflammatory autoimmune disease, affects nearly 1% of adults worldwide and significantly reduces health-related quality of life. (aspetjournals.org)
  • Standard measurements used to assess murine models of rheumatoid arthritis, notably paw thickness and clinical score, do not align well with certain aspects of disease severity as assessed by histopathology. (nih.gov)
  • The CVDs most commonly associated with pulmonary complications are systemic lupus erythematosus (SLE), scleroderma, rheumatoid arthritis (RA), mixed connective tissue disease (MCTD), polymyositis/dermatomyositis (PM/DM), and Sjögren's syndrome. (psychiatryadvisor.com)
  • Scientists know that this particular component of cartilage is being attacked by white blood cells and somehow this activates the immune system in the rheumatoid arthritic patient to develop antibodies to collagen type II. (appliedhealth.com)
  • The question now becomes how does collagen type II turn off the immune system in the rheumatoid arthritic. (appliedhealth.com)
  • Rheumatoid arthritis is a chronic inflammatory * disease that causes stiffness in the joints (places where bones meet), and can lead to disfigurement. (healthsparks.org)
  • Rheumatoid arthritis affects about 1.3 million adults in the United States, according to the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS, 2009). (healthsparks.org)
  • In addition, each collagen disease has its own specific set of immunological phenomena, such as the lupus (Le) cells and antinuclear reactions characteristic of systemic lupus erythematosus and the rheumatoid factor in rheumatoid arthritis. (thefreedictionary.com)
  • A term previously used to describe chronic diseases of the connective tissue (e.g., rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis), but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the connective tissue. (fpnotebook.com)
  • Herein we studied the influence of nimesulide and leflunomide combination in terms of disease symptoms and progression using collagen-induced arthritis model in mice, as a model for rheumatoid arthritis. (ox.ac.uk)
  • Gram-for-gram, some types of collagen fibrils are stronger than steel. (greenmedinfo.com)
  • Collagen-induced thrombogenesis was elicited in native blood drawn directly from an antecubital vein over immobilized type III collagen fibrils coated on a coverslip positioned in a parallel-plate perfusion chamber. (ahajournals.org)
  • 6 7 Thrombogenesis was elicited by immobilized type III collagen fibrils, and platelet-collagen adherence and platelet thrombus formation on the collagen surface were quantified. (ahajournals.org)
  • Schulte S, Unger C, Mo JA, et al: Arthritis-related B cell epitopes in collagen II are conformation-dependent and sterically privileged in accessible sites of cartilage collagen fibrils. (biomedcentral.com)
  • Collagen types I, II, III, V and XI self-assemble into D-periodic cross-striated fibrils. (news-medical.net)
  • Type V collagen and type XI collagen are minor components of tissue and occur as fibrils with type I and type II collagen respectively. (news-medical.net)
  • Biochemical assay of hydroxyproline revealed a 10% depletion of collagen in mildly affacted (grade I and II) leaflets, while a 20% depletion of fibrillar collagen was revealed by mapping the collagen fibrils onto the anatomy of cardiac leaflets using x-ray data. (ed.ac.uk)
  • These are called undifferentiated systemic rheumatic (connective tissue) diseases or overlap syndromes. (medlineplus.gov)
  • Cardiac tumours can mimic collagen vascular disease and they are often accompanied by profound systemic upset. (bmj.com)
  • Collagen vascular diseases are a complex group of systemic inflammatory diseases generally considered autoimmune in etiology. (springer.com)
  • Athersclerosis is a systemic disease. (healthtap.com)
  • Research shows that it is more effective to supplement with the nutrients your body uses to make the types of collagen it needs and to eliminate those habits that help to deplete vitamin C and weaken the collagen matrix. (greenmedinfo.com)
  • This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (fpnotebook.com)
  • Recently, defects in the regulation of the types of collagen synthesized and in the enzymes involved in the post-translational modifications have been found in heritable diseases of connective tissue. (meta.org)
  • In a class of diseases known as autoimmune disorders , the body's immune system attacks its own tissues. (medlineplus.gov)
  • The company announced today that it has found credible clinical studies proving that hydrolyzed collagen (Type II) is effective in reducing inflammation and swelling in conditions causing back pain, as well as in rebuilding connective tissues and in regenerating damaged cartilage, when consumed over a period of 12 months. (prweb.com)
  • In short, the results show that collagen intake, through supplements such as FLOBAX, stimulates the natural repair process of rebuilding and reinforcing the body's connective tissues. (prweb.com)
  • Pauling and Matthias Rath , MD, later completed a 15-year study in which they demonstrated that cancer is a collagen disease that is lethal when it metastasizes to the different tissues through the collagen matrix. (greenmedinfo.com)
  • And as far as the evidence so far available suggests, eating the amino acids that make up collagen separately doesn't have the same effect on those collagenous tissues as eating them together in a collagenous matrix. (marksdailyapple.com)
  • These are diseases that attack the connective tissues of blood vessels. (healthtap.com)
  • They are typically autoimmune disorders characterized by overactivity of the immune system resulting in auto-antibodies that attack the collagen connective tissue of blood vessels & other tissues, resulting in inlammation & weakness of the connecitve tissues. (healthtap.com)
  • Collagen vascular disease is typically an autoimmune disease which affects all sorts of tissues. (healthtap.com)
  • Lung tissues from IPF and non-IPF subjects were examined for collagen structure (second harmonic generation imaging) and LO gene (microarray analysis) and protein (immunohistochemistry and western blotting) levels. (biologists.org)
  • Increased collagen fibril thickness in IPF versus non-IPF lung tissues correlated with increased LOXL1/LOXL2, and decreased LOX, protein expression. (biologists.org)
  • They all are autoimmune diseases where the body's own immune system attacks healthy connective tissues such as the skin, bones, muscles, and ligaments, blood vessels etc. (tandurust.com)
  • It is now used to describe a collagen protein disorder in many types of connective tissues, not just blood vessels. (healthtap.com)
  • Due to increasing demand for such procedures, a number of rogue clinics have opened that are not adhering to the stringent guidelines dictating that collagen 'fillers' should be sourced only from tissues guaranteed to be free from Mad Cow. (enviroshop.com)
  • Collagen vascular diseases, sometimes called connective tissue diseases (CTDs) or autoimmune diseases, cover a wide array of disorders in which the body's natural immune or self-protection system fails to recognize its own tissues and goes on attack against itself. (healthsparks.org)
  • COL4A1 and COL4A2 encode the α 1 - and α 2 -chains of collagen type IV, a major component of basement membranes in various tissues including arteries. (cdc.gov)
  • There are 29 genetically distinct collagens present in animal tissues. (news-medical.net)
  • Type I collagen is found throughout the body except in cartilaginous tissues. (news-medical.net)
  • Collagen: Health and Disease" is a complete and detailed guide on basic collagen structure, its types, its synthesis and its functions in various tissues as well as diseases of collagen molecules. (innovativepublication.com)
  • tamela mann wrinkles (onabotulinumtoxinA) JUVDERM Family of Fillers KYBELLA Do not start any new medicines until you have told your doctor that you have received BOTOX Among the verteate species collagen is the most abundant protein and is associated with mineralization of their skeleton and dentition in all tissues except enamel. (phorbitech.eu)
  • What they found is that collagen VI is increased in brain tissues of Alzheimer's patients. (vitalitynow.org)
  • The collagens are the major structural glycoproteins of connective tissues. (meta.org)
  • Collagen vascular disease comes in a group of diseases called autoimmune disorders, wherein the immune system in the body attacks its own tissues mistakenly. (usarxmedicine.com)
  • The diseases might involve inflammation of arteries in tissues and arthritis. (usarxmedicine.com)
  • In fact, collagen makes up 70 to 90% of the muscles, tendons, ligaments and other joint supporting tissues and approximately 30% of the protein in the body. (thewholedog.com)
  • Collagen is a type of protein that creates structure and strength in many of our tissues. (deepmarine.com)
  • In scleroderma there is abnormal growth of collagen. (tandurust.com)
  • Scleroderma (pss) can turn the autonomically controlled bladder muscle wall to contract from collagen based scarring with contracture , but few other would do so! (healthtap.com)
  • In addition there is excess collagen formation and deposition in scleroderma. (news-medical.net)
  • In addition to the above mentioned disorders, excessive deposition of collagen occurs in scleroderma. (news-medical.net)
  • To determine the validity of this concept in vivo, the effect of administering TNF-neutralizing antibodies to mice with collagen-induced arthritis has been studied. (pnas.org)
  • in some collagen diseases, auto-immunization, particularly antinuclear antibodies, has been shown and circulating immune complexes are found. (thefreedictionary.com)
  • Holmdahl R, Rubin K, Klareskog L, Larsson E, Wigzell H: Characterization of the antibody response in mice with type II collagen-induced arthritis, using monoclonal anti-type II collagen antibodies. (biomedcentral.com)
  • Methods: Fibroblast-populated collagen lattice (FPCL) contraction assays using primary cell cultures derived from diseased and control fascia of the same DD patients were studied in response to exogenous TGF-beta2 and neutralizing anti-TGF-beta2 antibodies. (uwo.ca)
  • Neutralizing anti-TGF-beta2 antibodies abolished exogenous TGF-beta2 stimulated collagen contraction, but did not inhibit the enhanced basal collagen contraction activity of disease FPCL cultures. (uwo.ca)
  • Conclusions: Although exogenous TGF-beta2 stimulated both disease and control FPCL contraction, neutralizing anti-TGF-beta2 antibodies did not affect the elevated basal collagen contraction activity of disease FPCLs, suggesting that the differences in the collagen contraction activity of control and disease FPCL cultures are not due to differences in the levels of endogenous TGF-beta2 activity. (uwo.ca)
  • The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies. (semanticscholar.org)
  • see autoimmune disease autoimmune disease, any of a number of abnormal conditions caused when the body produces antibodies to its own substances. (thefreedictionary.com)
  • Fatigue, stress, and higher levels of certain antibodies also may lead to these diseases. (healthsparks.org)
  • Here, we use isoform-specific monoclonal antibodies to systematically reveal the localization of all six collagen IV isoforms in developing mouse eyes. (nih.gov)
  • Some disorders classified as collagen vascular disease affect your joints, skin, blood vessels, or other vital organs. (healthline.com)
  • Your blood vessels or the lining of your heart may become inflamed if you have this form of collagen vascular disease. (healthline.com)
  • These benefits are made possible through the natural healing process of the blood vessels, heart, and skin, which is essentially a process of collagen synthesis and remodeling. (prweb.com)
  • Testing showed that my arteries were as youthful as a baby's - zero percent plaque - which is also consistent with Pauling's and Rath's research that showed cardiovascular disease is actually arterial scurvy - a simple deficiency of vitamin C that weakens the collagen in the blood vessels. (greenmedinfo.com)
  • Collagen vascular disease was a term originally used to describe an abnormality of the collagen protein associated with blood vessels. (healthtap.com)
  • Did you know that the walls of your blood vessels are made of collagen and elastin? (collagencomplete.com)
  • Some people with this form of collagen vascular disease also have an inflammation of the blood vessels or of the heart's lining. (healthsparks.org)
  • Collagen is a protein-based connective tissue that forms a support system for your skin. (healthline.com)
  • This insertion induces eNCC-specific upregulation of Col6a4 expression that increases total collagen VI protein levels in the extracellular matrix (ECM) surrounding both the developing and the postnatal ENS. (jci.org)
  • Infectious protein aggregates from the skin of human patients can cause disease in mice. (the-scientist.com)
  • Boosting levels of a the immunosuppressive protein PD-L1 in blood stem cells halts diabetes in a mouse model of the disease. (the-scientist.com)
  • collagen" was once synonymous with "connective tissue" rather than describing a specific fibrinous protein in that tissue. (thefreedictionary.com)
  • collagen" was once synonymous with "connective tissue" rather than describing a specific protein in that tissue. (thefreedictionary.com)
  • Mutations in the genes COL4A1/COL4A2 cause BM defects due to mutant protein incorporation or its absence by ER retention and ER-stress due to intracellular retention of collagen IV. (omicsonline.org)
  • Collagen is a family of highly fibrous proteins found in all animals, and is the most abundant type of protein found in mammals, constituting up to 25% of the total protein mass. (prweb.com)
  • Our data indicates that these four single missense mutations cause BFPP mostly by abolishing the ability of GPR56 to bind to its ligand, collagen III, in addition to affecting GPR56 protein surface expression as previously shown. (harvard.edu)
  • Collagen is the most abundant protein in the body, providing tensile strength to our bones, teeth [5] , ligaments, tendons [6] , and cartilage. (marksdailyapple.com)
  • Collagen is a tough, glue-like protein that represents 30% of body protein. (neuromedcenter.com)
  • Collagen is a protein which makes up the connective tissue. (tandurust.com)
  • Collagen vascular disease occurs when problems with the immune system affect collagen.Collagen is a tough, fiber -like protein that makes up 30% of body protein. (healthtap.com)
  • Super Collagen + C is a complex protein that rejuvenates and revitalizes cell Best Medical & Cosmetic Dermatology and Plastic Surgery in Fullerton Newport Beach and Los Angeles areas. (phorbitech.eu)
  • Using specialized imaging they showed that collagen VI and the Alzheimer's proteins form large aggregates with each other that may keep the smaller, more toxic protein complexes away from neurons. (vitalitynow.org)
  • Collagen, as you may know is the elastic protein that holds skin together. (thewholedog.com)
  • We previously fused the collagen-binding domain (CBD) and polycystic kidney disease (PKD) domain of Clostridium histolyticum class II collagenase (ColH) to bFGF and showed that the subcutaneous injection of this collagen-binding bFGF fusion protein (bFGF-PKD-CBD) without carrier into nude mice had more potent skin fibroblast growth-promoting effects at the injection site than native bFGF [ 17 ]. (biomedcentral.com)
  • Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. (pnas.org)
  • Collagen vascular diseases can be heritable (inherited from one's parents) or autoimmune (resulting from activity of the body's immune system against itself). (healthline.com)
  • With age, the body's inability to produce and regenerate these collagen matrices leads to wear and tear on the joints, causing pain, stiffness, decreased function, and sometimes even deformities due to joint misalignments. (prweb.com)
  • Even so, there are enzymes in cancer cells that can eat through your body's collagen . (greenmedinfo.com)
  • Collagen Fibre Disease Rhinoplasty Surgery mass say it blocks your body's power to and your skin still itchy Avoid skin damage and ignore skincare products that contain alcohol. (phorbitech.eu)
  • The body's production of collagen slows with aging. (articlealley.com)
  • Stallmach A, Schuppan D, Riese HH, Metthes H, Riecken EO (1992) Increased collagen type III synthesis by fibroblasts isolated from strictures of patients with Crohn's disease. (springer.com)
  • In primary demyelinating disease, MS, a renewed interest in the role of humoral immunity in the pathophysiology has been investigated because oligoclonalIgG band in the CSF and increased intrathecalIgG synthesis are used as an auxiliary diagnosis measure. (biomedcentral.com)
  • IL-13 Promotes Collagen Accumulation in Crohn s Disease Fibrosis by Down-Regulation of Fibroblast MMP Synthesis: A Role for Innate Lymphoid Cells? (crohnsforum.com)
  • In fCD muscle extracts, collagen synthesis was significantly increased compared to other groups, but MMP-2 was not co-ordinately increased. (crohnsforum.com)
  • Thus far, the primary heritable disorders of collagen metabolism in man include lysyl hydroxylase deficiency in Ehlers-Danlos syndrome type VI, p-collagen peptidase deficency in Ehlers-Danlos syndrome type VII, decreased synthesis of type III collagen in Ehlers-Danlos syndrome ty. (meta.org)
  • These defects often cause problems in the biosynthesis of the collagen molecules, their assembly and posttranslational modification process that makes them their final end form of collagen. (news-medical.net)
  • Understanding where and when collagen IV molecules are expressed is important because it defines limits for the location and timing of primary pathogenesis. (nih.gov)
  • In this issue of the JCI , Soret and colleagues identify a new mechanism that causes HSCR-like disease in mice and involves deposition of excess collagen VI in the intestine by migrating ENS precursors as they colonize fetal bowel. (jci.org)
  • If it happens that you do have Peyronie's disease you will want to begin a conservative course of care to help your body heal and repair the infiltration of excess collagen in the deep tissue of the shaft. (peyronies-disease-help.com)
  • I can't take collagen. (healingwell.com)
  • First, since glycine is often cited as the main reason to consume gelatinous meats and take collagen hydrolysate supplements, couldn't we just take supplementary glycine? (marksdailyapple.com)
  • When a person who has arthritis begins to take collagen type II, they should wait of a period of four to eight weeks before they make a decision as to whether or not the product is working. (blogspot.com)
  • To provide novel insights into collagen diseases mechanisms, this study aimed to investigate the effect of defined engineered biointerfaces on cell behavior/signaling and collagen folding, secretion and degradation in COL4A2 mutant and wild-type cells. (omicsonline.org)
  • The CHO-derived recombinant type VII collagen (CHO-rhC7), similar to FB-rhC7, was secreted as a correctly folded, disulfide-bonded, helical trimer resistant to protease degradation. (nih.gov)
  • Consequently, matrix degradation is down-regulated and this leads to excessive collagen deposition. (crohnsforum.com)
  • Ferdinando Mannello, Virginia Medda, Daniela Ligi and Joseph D. Raffetto, "Glycosaminoglycan Sulodexide Inhibition of MMP-9 Gelatinase Secretion and Activity: Possible Pharmacological Role Against Collagen Degradation in Vascular Chronic Diseases", Current Vascular Pharmacology (2013) 11: 354. (eurekaselect.com)
  • This is not a coincidence.Humans and dogs as well suffer from age related joint and soft tissue pain due to collagen loss and degradation. (thewholedog.com)
  • Rats implanted with vagus nerve cuff electrodes had collagen-induced arthritis induced and were followed for 15 days. (sigmaaldrich.com)
  • In one study [7] , rats with osteoporosis ate collagen hydrolysate that scientists had marked with a radioactive signature to allow them to track its course through the body. (marksdailyapple.com)
  • Paw volumes of healthy rats indicated natural growth, and disease status was measured by paw edema. (aspetjournals.org)
  • Female rats showed a higher incidence of CIA, earlier disease onset, and more severe symptoms. (aspetjournals.org)
  • Factors potentially modulating collagen deposition were examined in intestinal tissue samples from fibrotic (f) CD and compared with cancer control (C), ulcerative colitis (UC) and uninvolved (u) CD. (crohnsforum.com)
  • Structural and compositional basement membrane defects and ER stress due to Col4a1 mutations cause glomerular and tubular kidney disease, and indicate cell-type-specific disease mechanisms for collagen diseases. (biologists.org)
  • Mutations in the BMs major component collagen IV can cause eye and kidney defects and cerebrovascular disease including intracerebral hemorrhages (ICH). (omicsonline.org)
  • While ER-retention of collagen IV and ER-stress are associated with hemorrhagic stroke caused by a COL4A2 mutation, the mechanism(s) of collagen IV mutations disease remain poorly characterized. (omicsonline.org)
  • Collectively, these data provide a beginning to our understanding of how these mutations affect cell function/behavior and also increase our knowledge of the disease mechanisms. (omicsonline.org)
  • The data can in the long term be used to the development of new therapeutic approaches for ICH and pathologies due to collagen IV mutations. (omicsonline.org)
  • This domain contains four disease-associated mutations and two N-glycosylation sites. (harvard.edu)
  • Our study reveals that although glycosylation is not required for ligand binding, each of the four disease-associated mutations completely abolish the ligand binding ability of GPR56. (harvard.edu)
  • It is due to mutations in the gene encoding type VII collagen (C7). (nih.gov)
  • COL4A1 Mutations Cause Neuromuscular Disease with Tissue-Specific Mechanistic Heterogeneity. (cdc.gov)
  • The autosomal disease generally results from mutations in the COL4A3 or COL4A4 genes and has been seen in both recessive and dominant patterns of transmission. (arizona.edu)
  • Disease-causing mutations in each of the six genes are identified in humans or mice and frequently include diverse ocular pathogenesis that encompass common congenital and progressive blinding diseases, such as optic nerve hypoplasia, glaucoma, and retinal degeneration. (nih.gov)
  • Collagen type VI-related disorders are caused by alterations ( mutations ) of collagen genes ( COL6A1 , COL6A2 , or COL6A3 genes) and include diseases that are mild like Bethlem myopathy or more severe like the Ullrich congenital muscular dystrophy (CMD). (cdc.gov)
  • Diagnosis depends on typical clinical features, muscle biopsy (for suspected Ullrich CMD) or skin biopsy (for suspected Bethlem myopathy) and genetic testing that shows mutations in the collagen VI genes. (cdc.gov)
  • TN3-19.12, a hamster IgG1 monoclonal antibody to murine TNF-alpha/beta, was injected i.p. into mice either before the onset of arthritis or after the establishment of clinical disease. (pnas.org)
  • Mice who ate radioactive collagen hydrolysate showed increased radioactivity in the knee joint. (marksdailyapple.com)
  • Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice. (nih.gov)
  • Synovial cells isolated from the knee joints of naive or sham-immunized mice, or from mice immunized with collagen but without arthritis, released little or no detectable VEGF. (eurekamag.com)
  • The levels of VEGF secreted by synovial cells isolated from the joints of mice with severe arthritis were significantly higher than from mice with mild disease. (eurekamag.com)
  • Courtenay JS, Dallman MJ, Dayan AD, Martin A, Mosedale B: Immunisation against heterologous type II collagen induces arthritis in mice. (biomedcentral.com)
  • Although localization of collagen IV isoforms in developed human eyes is known, the spatial and temporal distribution of type IV collagens throughout ocular development has not been determined in humans or in mice. (nih.gov)
  • This analysis revealed the striking increase in collagen VI in the brains of mice that model AD. (vitalitynow.org)
  • Collagen-vascular diseases (CVDs) are a heterogeneous group of autoimmune disorders characterized by the presence of autoantibodies. (medscape.com)
  • Collagen disease coexists in demyelinating disorders and frequently various collagen disease related autoantibodies are positive in daily practice. (biomedcentral.com)
  • The discovery of various autoantibodies in all collagen diseases is of great diagnostic significance and is used widely in clinical practice. (thefreedictionary.com)
  • However, corticosteroid and immunosuppressant medications commonly treat many connective tissue diseases. (healthline.com)
  • The pathogenesis of connective-tissue diseases is unknown. (medscape.com)
  • Since collagen diseases are characterized by damage to all the structural components of connective tissue-the fibers, the cells, and the basic intracellular substances-the term "connective-tissue diseases" might be more suitable. (thefreedictionary.com)
  • People who developed these disorders were previously said to have "connective tissue" or "collagen vascular" disease. (medlineplus.gov)
  • Collagen vascular disease" is the name of a group of diseases that affect your connective tissue. (healthline.com)
  • Collagen vascular disease is sometimes also called connective tissue disease. (healthline.com)
  • Approximately 15% of patients with an interstitial lung disease have an underlying connective-tissue disease. (medscape.com)
  • ILD may be the initial manifestation of a connective-tissue disease. (medscape.com)
  • [ 4 ] It has been suggested that some patients who have ILD but who do not meet clinical criteria for connective-tissue disorders may have a lung-predominant form of a connective-tissue disease. (medscape.com)
  • Methionine metabolism depletes glycine, so the more meat you eat, the more glycine-rich connective tissue, bone broth [3] , and collagen supplements [4] you should be eating to balance out the amino acids. (marksdailyapple.com)
  • You can think of collagen as sort of the glue and supporting tissue that holds our bodies together. (healthtap.com)
  • Functional effects (collagen structure and tissue stiffness using atomic force microscopy) of LO inhibitors on collagen remodelling were examined in two models, collagen hydrogels and decellularized human lung matrices. (biologists.org)
  • Levels of the following collagen biomarkers were measured: N-terminal pro-peptide of type III procollagen (PIIINP), C-terminal telopeptide of collagen type I (CITP), matrix metalloproteinase (MMP)-9, and tissue inhibitor of metalloproteinase (TIMP)-1. (acc.org)
  • Collagen vascular disease is a terminology used for group of disorders that pertains to problems related with connective tissue in the body. (tandurust.com)
  • Hence collagen vascular disease is also referred as connective tissue disorder by many. (tandurust.com)
  • Collagen provides strength and support to the tissue. (tandurust.com)
  • The purpose of this study was to further explore this hypothesis by examining the effects of TGF-beta2 on primary cell cultures derived from patient-matched disease and normal palmar fascia tissue using a three-dimensional collagen contraction assay. (uwo.ca)
  • Often patients with rheumatologic diseases are on chemotherapy, which creates the potential concern for radiosensitivity of the tissue. (ciannamedical.com)
  • UK Tests have already found illegal and potentially contaminated collagen in widespread use, derived from dead cows, birds, and human tissue. (enviroshop.com)
  • Collagen vascular disease refers to a group of diseases that affect your connective tissue. (healthsparks.org)
  • I really felt that from all my research it was connected to connective tissue disease. (healthcaremagic.com)
  • The purpose of this review is to summarize the clinical reports linking 13q34 to coronary artery disease, atherosclerosis, and artery stiffening and to assemble the scattered pieces of evidence from experimental studies based on vascular cells and tissue collectively supporting a role for collagen type IV in atherosclerosis and other macrovascular disease conditions. (cdc.gov)
  • This is the collagen of granulation tissue, and is produced quickly by young fibroblasts before the tougher type I collagen is synthesized. (news-medical.net)
  • Nonetheless, it is most important to recognize that a ll clinical signs and symptoms of Peyronie's disease originate from the effects of the plaque upon the internal tissue layers ( tunica albuginea ) of the penis. (peyronies-disease-help.com)
  • Peyronie's plaques, or scars, later combine the dense threads of fibrin connective tissue with reduced and fragmented elastic connective tissue fibers, as well as excessive amounts of type III collagen material, which happens to be specially inclined to excessive scar development. (peyronies-disease-help.com)
  • The normal tunica albuginea is composed of elastin fibers and collagen, although the site of scar tissue from Peyronie's disease is composed mostly of collagen. (peyronies-disease-help.com)
  • collagenoses, a group of diseases characterized by primary, usually progressive, affection of the connective tissue and vascular walls of various organs. (thefreedictionary.com)
  • The term "collagen diseases" was suggested by the American scientist P. Klemperer in 1942 to describe a process manifested by swelling of the collagenous fibers (an element of connective tissue). (thefreedictionary.com)
  • Most people are aware of how important collagen is for your joint cartilage and muscle tissue, but prior to this study no one knew just how important it was to your brain. (vitalitynow.org)
  • Based off these findings the team then examined brain tissue from AD patients and normal non-demented humans and found that collagen VI expression was also higher in the AD patients. (vitalitynow.org)
  • such defects could result in a connective tissue disease. (meta.org)
  • Individuals, who developed these diseases, were previously said to experience CVD or connective tissue disorder. (usarxmedicine.com)
  • To relieve collagen vascular disease in an ideal manner, order Soma online overnight, a strong muscle relaxer used to heal painful tissue, joint and muscle conditions. (usarxmedicine.com)
  • Collagen is found in abundance in the joints and connective tissue of the body. (thewholedog.com)
  • As happens in the skin, when collagen breaks down in the body, the joints become less stable, the muscles and connective tissue loosen and become more brittle, and disorders such as arthritis, degenerative disc disease, tendonitis and overuse injuries begin to occur. (thewholedog.com)
  • All of these maladies are failure of collagen, the building block of our entire skeletal system, which serves as elastic in our connective tissue. (thewholedog.com)
  • As a result of an examination, she was diagnosed as mixed connective tissue disease called collagen disease. (blogspot.com)
  • Anti-TNF administered prior to disease onset significantly reduced paw swelling and histological severity of arthritis without reducing the incidence of arthritis or the level of circulating anti-type II collagen IgG. (pnas.org)
  • Both forms of arthritis affect the joints, but osteoarthritis affects them more significantly because it is a degenerative disease. (k9collagen.com)
  • More relevant to human disease was the capacity of the antibody to reduce the clinical score, paw swelling, and the histological severity of disease even when injected after the onset of clinical arthritis. (pnas.org)
  • Pleural involvement by these diseases is variable in severity, and its onset may. (springer.com)
  • PIIINP levels increased with the severity of disease (p = 0.002). (acc.org)
  • Our data demonstrate that, in collagen-induced arthritis, expression of the potent angiogenic cytokine VEGF correlates with disease severity. (eurekamag.com)
  • Add to this the fact that the number one killer in our country today is still cardiovascular disease, and you have all of the conditions necessary for a plethora of pharmaceutical and natural medicines designed to reduce the severity of these diseases. (appliedhealth.com)
  • It is claimed that the severity of the lenticonus is a valuable marker in judging the overall disease severity. (arizona.edu)
  • This led researchers to conclude that hip dysplasia was a polygenic disease (residing in more than one gene), meaning that the severity of the disease could be influenced by environmental factors such as diet and lifestyle. (thewholedog.com)
  • Importantly, for a majority of patients in a HSCR cohort, the myenteric ganglia from the ganglionated region are also specifically surrounded by abundant collagen VI microfibrils, an outcome accentuated by Down syndrome. (jci.org)
  • Type I is the principle collagen found in skin and bone and is by far the most abundant type found in the body (representing 90% of body collagen). (prweb.com)
  • These form the most abundant collagens in vertebrates. (news-medical.net)
  • This is the most abundant collagen of the human body. (news-medical.net)
  • Structural remodelling of the extracellular matrix [i.e. collagen cross-linking mediated by the lysyl oxidase (LO) family of enzymes (LOX, LOXL1-4)] might contribute to disease pathogenesis and represent a therapeutic target. (biologists.org)
  • transmembrane collagen, interacts with integrin a1b1, fibronectin and components of basement membranes like nidogen and perlecan. (news-medical.net)
  • All result from a defect in type IV collagen found in basement membranes. (arizona.edu)
  • Lampe AK, Flanigan KM, Bushby KM & Hicks D. Collagen Type VI-Related Disorders. (cdc.gov)
  • This has enabled to address the hypothesis that biomaterials can alter collagen mutant cells behavior by overcoming some of the defects caused and rescuing downstream effect of ER stress. (omicsonline.org)
  • The collagen linked diseases commonly arise from genetic defects or nutritional deficiencies. (news-medical.net)
  • There may be defects in collagen secretion and general production as well. (news-medical.net)
  • Collagen-related diseases most commonly arise from genetic defects or nutritional deficiencies that affect the biosynthesis, assembly, postranslational modification, secretion, or other processes involved in normal collagen production. (news-medical.net)
  • S. Negm , Gastroduodenal changes in collagen diseases, New Egypt. (who.int)
  • Among the numerous theories of the developmental mechanisms of collagen diseases, the most widely accepted is that they are of infectious-allergic origin (in particular, autoimmune genesis). (thefreedictionary.com)
  • This comprehensive analysis defines the spatial and temporal distribution of type IV collagen isoforms in the developing eye, and will contribute to understanding the mechanisms underlying collagen IV-related ocular diseases that collectively lead to blindness in millions of people worldwide. (nih.gov)
  • Here, we report the generation of a mouse model for HSCR - named Holstein - that contains an untargeted transgenic insertion upstream of the collagen-6α4 ( Col6a4 ) gene. (jci.org)
  • A combination gene-and-cell therapy has given a boy with a grievous skin disease a new lease on life, and has resolved a dermatology debate to boot. (the-scientist.com)
  • An important gene associated with Type Ii Collagen Disorders is COL2A1 (Collagen Type II Alpha 1 Chain). (malacards.org)
  • pertains to those conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (fpnotebook.com)
  • Inhibition of LO activity alleviates fibrosis by limiting fibrillar collagen cross-linking, thereby potentially impeding the formation of a pathological microenvironment in IPF. (biologists.org)
  • In this presentation, I will decode the temporal and spatial demyelinating processes in collagen diseases and show practical approaches and treatments. (biomedcentral.com)
  • In one series all patients with X-linked disease had temporal thinning suggesting that this might be a useful diagnostic sign. (arizona.edu)
  • Using recombinant human C7 (rhC7) purified from human dermal fibroblasts (FB-rhC7), we showed previously that intravenously injected rhC7 distributed to engrafted RDEB skin, incorporated into its dermal-epidermal junction (DEJ), and reversed the RDEB disease phenotype. (nih.gov)
  • Stumpf M, Cao W, Klinge U, Klosterhalfen B, Kasperk R, Schumpelick V (2001) Increased distribution of collagen type III and reduced expression of matrix metalloproteinase 1 in patients with diverticular disease. (springer.com)
  • Our objective in this study was to measure the kinetics of VEGF production in a murine model of collagen-induced arthritis and to determine whether VEGF blockade reduces disease progression. (eurekamag.com)
  • Trentham DE, Townes AS, Kang AH: Autoimmunity to type II collagen an experimental model of arthritis. (biomedcentral.com)
  • Holmdahl R, Andersson M, Goldschmidt TJ, Gustafsson K, Jansson L, Mo JA: Type II collagen autoimmunity in animals and provocations leading to arthritis. (biomedcentral.com)
  • It may turn out that the natural components of cartilage hold the greatest promise of ameliorating both arthritis and heart disease. (appliedhealth.com)
  • I became interested in collagen type II as a treatment for arthritis and heart disease while researching cartilage and writing my book, " Jaws for Life, the Story of Shark Cartilage . (appliedhealth.com)
  • When people suffer from arthritis, there is a selective destruction of collagen type II in the joint cartilage itself. (appliedhealth.com)
  • Nimesulide improves the symptomatic and disease modifying effects of leflunomide in collagen induced arthritis. (ox.ac.uk)
  • Collagen induced arthritis was induced by immunization with type II collagen. (ox.ac.uk)
  • Leflunomide alone moderately alleviates the symptoms of arthritis and moderately retarded the radiological and pathological disease progression. (ox.ac.uk)
  • Combination of nimesulide and leflunomide significantly improved symptomatic (analgesia and joint stiffness) and arthritic disease progression (radiological, pathological and Myeloperoxidase enzyme activity) in collagen induced arthritis animal model. (ox.ac.uk)
  • Alport syndrome is a hereditary type IV collagen disease leading to progressive renal fibrosis, hearing loss and ocular changes. (uzh.ch)
  • X-linked Alport syndrome is a basement membrane disease with important ocular manifestations. (arizona.edu)
  • However, there is considerable clinical and genetic heterogeneity and not all patients have the complete syndrome of nephritis, deafness and ocular disease. (arizona.edu)
  • Stumpf M, Cao W, Klinge U, Klosterhalfen B, Junge K, Krones CJ, Schumpelick V (2005) Reduced expression of collagen type I and increased expression of matrix metalloproteinases 1 in patients with Crohn's Disease. (springer.com)
  • Abstract The objective of the present study was to investigate collagen-induced platelet thrombus formation at arterial blood flow conditions in nonanticoagulated blood from habitual smokers and from nonsmoking patients with severe peripheral atherosclerotic disease. (ahajournals.org)
  • The extensive work of Dr. John Prudden, M.D., F.A.C.S., have proven that bovine collagen supplements, one of the key active ingredients in FLOBAX, have a beneficial and healing effect on the collagen matrix found in joint cartilage. (prweb.com)
  • The authors concluded that markers of collagen metabolism were associated with worse disease in patients with PAH. (acc.org)