Lip: Either of the two fleshy, full-blooded margins of the mouth.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).Cleft Lip: Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.Collagen Type I: The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.Lip Neoplasms: Tumors or cancer of the LIP.Lip DiseasesFibrillar Collagens: A family of structurally related collagens that form the characteristic collagen fibril bundles seen in CONNECTIVE TISSUE.Collagen Type IV: A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.Collagen Type III: A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.Receptors, Collagen: Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI.Collagen Type II: A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.Collagen Type VI: A non-fibrillar collagen that forms a network of MICROFIBRILS within the EXTRACELLULAR MATRIX of CONNECTIVE TISSUE. The alpha subunits of collagen type VI assemble into antiparallel, overlapping dimers which then align to form tetramers.Cleft Palate: Congenital fissure of the soft and/or hard palate, due to faulty fusion.Collagen Type V: A fibrillar collagen found widely distributed as a minor component in tissues that contain COLLAGEN TYPE I and COLLAGEN TYPE III. It is a heterotrimeric molecule composed of alpha1(V), alpha2(V) and alpha3(V) subunits. Several forms of collagen type V exist depending upon the composition of the subunits that form the trimer.Collagen Diseases: Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)Extracellular Matrix: A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.Procollagen: A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.Collagen Type XVIII: A non-fibrillar collagen found in BASEMENT MEMBRANE. The C-terminal end of the alpha1 chain of collagen type XVIII contains the ENDOSTATIN peptide, which can be released by proteolytic cleavage.Hydroxyproline: A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.Collagen Type XI: A fibrillar collagen found primarily in interstitial CARTILAGE. Collagen type XI is heterotrimer containing alpha1(XI), alpha2(XI) and alpha3(XI) subunits.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Hydroxylysine: A hydroxylated derivative of the amino acid LYSINE that is present in certain collagens.Cartilage: A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Gels: Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.Fibril-Associated Collagens: A family of non-fibrillar collagens that interact with FIBRILLAR COLLAGENS. They contain short triple helical domains interrupted by short non-helical domains and do not form into collagen fibrils.Basement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Collagen Type X: A non-fibrillar collagen found primarily in terminally differentiated hypertrophic CHONDROCYTES. It is a homotrimer of three identical alpha1(X) subunits.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Extracellular Matrix Proteins: Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).Tendons: Fibrous bands or cords of CONNECTIVE TISSUE at the ends of SKELETAL MUSCLE FIBERS that serve to attach the MUSCLES to bones and other structures.Collagen Type XII: A fibril-associated collagen found in many tissues bearing high tensile stress, such as TENDONS and LIGAMENTS. It is comprised of a trimer of three identical alpha1(XII) chains.Microbial Collagenase: A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from Clostridium histolyticum that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.Collagen Type VII: A non-fibrillar collagen involved in anchoring the epidermal BASEMENT MEMBRANE to underlying tissue. It is a homotrimer comprised of C-terminal and N-terminal globular domains connected by a central triple-helical region.Fibronectins: Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.Pepsin A: Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.Connective Tissue: Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.Proteoglycans: Glycoproteins which have a very high polysaccharide content.Collagenases: Enzymes that catalyze the degradation of collagen by acting on the peptide bonds.Fibrosis: Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.Cartilage, Articular: A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.Non-Fibrillar Collagens: A family of structurally-related short-chain collagens that do not form large fibril bundles.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Collagen Type VIII: A non-fibrillar collagen originally found in DESCEMET MEMBRANE. It is expressed in endothelial cell layers and in tissues undergoing active remodeling. It is heterotrimer comprised of alpha1(VIII) and alpha2(VIII) chains.Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Laminin: Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.ElastinMicroscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Osteogenesis Imperfecta: COLLAGEN DISEASES characterized by brittle, osteoporotic, and easily fractured bones. It may also present with blue sclerae, loose joints, and imperfect dentin formation. Most types are autosomal dominant and are associated with mutations in COLLAGEN TYPE I.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase: A mixed-function oxygenase that catalyzes the hydroxylation of peptidyllysine, usually in protocollagen, to peptidylhydroxylysine. The enzyme utilizes molecular oxygen with concomitant oxidative decarboxylation of the cosubstrate 2-oxoglutarate to succinate. EC 1.14.11.4.Proline: A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.Aminopropionitrile: Reagent used as an intermediate in the manufacture of beta-alanine and pantothenic acid.Decorin: A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.Cell Adhesion: Adherence of cells to surfaces or to other cells.Chick Embryo: The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Transforming Growth Factor beta: A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.Collagen Type XIII: A non-fibrillar collagen found as a ubiquitously expressed membrane- associated protein. Type XIII collagen contains both collagenous and non-collagenous domains along with a transmembrane domain within its N-terminal region.Microscopy, Electron, Scanning: Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.Integrin alpha1beta1: Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.Chondrocytes: Polymorphic cells that form cartilage.Wound Healing: Restoration of integrity to traumatized tissue.Microscopy, Polarization: Microscopy using polarized light in which phenomena due to the preferential orientation of optical properties with respect to the vibration plane of the polarized light are made visible and correlated parameters are made measurable.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Matrix Metalloproteinase 1: A member of the metalloproteinase family of enzymes that is principally responsible for cleaving FIBRILLAR COLLAGEN. It can degrade interstitial collagens, types I, II and III.Integrins: A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.Peptide Fragments: Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.Cornea: The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)Facial Muscles: Muscles of facial expression or mimetic muscles that include the numerous muscles supplied by the facial nerve that are attached to and move the skin of the face. (From Stedman, 25th ed)Gelatin: A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Transforming Growth Factor beta1: A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.HSP47 Heat-Shock Proteins: Basic glycoprotein members of the SERPIN SUPERFAMILY that function as COLLAGEN-specific MOLECULAR CHAPERONES in the ENDOPLASMIC RETICULUM.Procollagen-Proline Dioxygenase: A mixed-function oxygenase that catalyzes the hydroxylation of a prolyl-glycyl containing peptide, usually in PROTOCOLLAGEN, to a hydroxyprolylglycyl-containing-peptide. The enzyme utilizes molecular OXYGEN with a concomitant oxidative decarboxylation of 2-oxoglutarate to SUCCINATE. The enzyme occurs as a tetramer of two alpha and two beta subunits. The beta subunit of procollagen-proline dioxygenase is identical to the enzyme PROTEIN DISULFIDE-ISOMERASES.Tensile Strength: The maximum stress a material subjected to a stretching load can withstand without tearing. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed, p2001)Glycosaminoglycans: Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.Protein-Lysine 6-Oxidase: An enzyme oxidizing peptidyl-lysyl-peptide in the presence of water & molecular oxygen to yield peptidyl-allysyl-peptide plus ammonia & hydrogen peroxide. EC 1.4.3.13.Tissue Engineering: Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.Cheilitis: Inflammation of the lips. It is of various etiologies and degrees of pathology.Corneal Stroma: The lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Integrin alpha2: An integrin alpha subunit that primarily combines with INTEGRIN BETA1 to form the INTEGRIN ALPHA2BETA1 heterodimer. It contains a domain which has homology to collagen-binding domains found in von Willebrand factor.Platelet Adhesiveness: The process whereby PLATELETS adhere to something other than platelets, e.g., COLLAGEN; BASEMENT MEMBRANE; MICROFIBRILS; or other "foreign" surfaces.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Dermis: A layer of vascularized connective tissue underneath the EPIDERMIS. The surface of the dermis contains innervated papillae. Embedded in or beneath the dermis are SWEAT GLANDS; HAIR FOLLICLES; and SEBACEOUS GLANDS.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Cyanogen Bromide: Cyanogen bromide (CNBr). A compound used in molecular biology to digest some proteins and as a coupling reagent for phosphoroamidate or pyrophosphate internucleotide bonds in DNA duplexes.Stress, Mechanical: A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.Platelet Aggregation: The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.Tissue Scaffolds: Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.Matrix Metalloproteinases: A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Peptides: Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Matrix Metalloproteinase 2: A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Fluorescent Antibody Technique: Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.Biomechanical Phenomena: The properties, processes, and behavior of biological systems under the action of mechanical forces.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Integrin alpha1: An integrin alpha subunit that binds COLLAGEN and LAMININ though its I domain. It combines with INTEGRIN BETA1 to form the heterodimer INTEGRIN ALPHA1BETA1.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Descemet Membrane: A layer of the cornea. It is the basal lamina of the CORNEAL ENDOTHELIUM (from which it is secreted) separating it from the CORNEAL STROMA. It is a homogeneous structure composed of fine collagenous filaments, and slowly increases in thickness with age.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.Keloid: A sharply elevated, irregularly shaped, progressively enlarging scar resulting from formation of excessive amounts of collagen in the dermis during connective tissue repair. It is differentiated from a hypertrophic scar (CICATRIX, HYPERTROPHIC) in that the former does not spread to surrounding tissues.Receptors, Mitogen: Glycoprotein molecules on the surface of B- and T-lymphocytes, that react with molecules of antilymphocyte sera, lectins, and other agents which induce blast transformation of lymphocytes.Growth Plate: The area between the EPIPHYSIS and the DIAPHYSIS within which bone growth occurs.Cell Culture Techniques: Methods for maintaining or growing CELLS in vitro.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Calcification, Physiologic: Process by which organic tissue becomes hardened by the physiologic deposit of calcium salts.Metalloendopeptidases: ENDOPEPTIDASES which use a metal such as ZINC in the catalytic mechanism.Amino Acids: Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.Aggrecans: Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.Tissue Inhibitor of Metalloproteinase-1: A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a N-glycosylated protein, molecular weight 28 kD, produced by a vast range of cell types and found in a variety of tissues and body fluids. It has been shown to suppress metastasis and inhibit tumor invasion in vitro.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Mice, Inbred C57BLElastic Tissue: Connective tissue comprised chiefly of elastic fibers. Elastic fibers have two components: ELASTIN and MICROFIBRILS.Tropocollagen: The molecular unit of collagen fibrils that consist of repeating three-stranded polypeptide units arranged head to tail in parallel bundles. It is a right-handed triple helix composed of 2 polypeptide chains. It is rich in glycine, proline, hydroxyproline, and hydroxylysine.Skin Aging: The process of aging due to changes in the structure and elasticity of the skin over time. It may be a part of physiological aging or it may be due to the effects of ultraviolet radiation, usually through exposure to sunlight.Arthritis, Experimental: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Cross-Linking Reagents: Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other.Microscopy, Electron, Transmission: Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.Cicatrix: The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.Nephritis, Hereditary: A group of inherited conditions characterized initially by HEMATURIA and slowly progressing to RENAL INSUFFICIENCY. The most common form is the Alport syndrome (hereditary nephritis with HEARING LOSS) which is caused by mutations in genes for TYPE IV COLLAGEN and defective GLOMERULAR BASEMENT MEMBRANE.Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Antigens, CD29: Integrin beta-1 chains which are expressed as heterodimers that are noncovalently associated with specific alpha-chains of the CD49 family (CD49a-f). CD29 is expressed on resting and activated leukocytes and is a marker for all of the very late activation antigens on cells. (from: Barclay et al., The Leukocyte Antigen FactsBook, 1993, p164)Kinetics: The rate dynamics in chemical or physical systems.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Matrix Metalloproteinase 8: A member of the MATRIX METALLOPROTEINASES that cleaves triple-helical COLLAGEN types I, II, and III.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Platelet Membrane Glycoproteins: Surface glycoproteins on platelets which have a key role in hemostasis and thrombosis such as platelet adhesion and aggregation. Many of these are receptors.Lung: Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.Gelatinases: A class of enzymes that catalyzes the degradation of gelatin by acting on the peptide bonds. EC 3.4.24.-.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Osteonectin: Non-collagenous, calcium-binding glycoprotein of developing bone. It links collagen to mineral in the bone matrix. In the synonym SPARC glycoprotein, the acronym stands for Secreted Protein, Acidic and Rich in Cysteine.Actins: Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.Protein Denaturation: Disruption of the non-covalent bonds and/or disulfide bonds responsible for maintaining the three-dimensional shape and activity of the native protein.Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Face: The anterior portion of the head that includes the skin, muscles, and structures of the forehead, eyes, nose, mouth, cheeks, and jaw.Tissue Inhibitor of Metalloproteinases: A family of secreted protease inhibitory proteins that regulates the activity of SECRETED MATRIX METALLOENDOPEPTIDASES. They play an important role in modulating the proteolysis of EXTRACELLULAR MATRIX, most notably during tissue remodeling and inflammatory processes.Microfibrils: Components of the extracellular matrix consisting primarily of fibrillin. They are essential for the integrity of elastic fibers.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.Platelet Activation: A series of progressive, overlapping events, triggered by exposure of the PLATELETS to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug.Osteogenesis: The process of bone formation. Histogenesis of bone including ossification.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Chickens: Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA.Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.ArthritisHyaluronic Acid: A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.Smiling: A facial expression which may denote feelings of pleasure, affection, amusement, etc.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Protein Structure, Tertiary: The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.Bone Matrix: Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.Sclera: The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)Oral Surgical Procedures: Surgical procedures used to treat disease, injuries, and defects of the oral and maxillofacial region.Matrix Metalloproteinase 9: An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.Palate: The structure that forms the roof of the mouth. It consists of the anterior hard palate (PALATE, HARD) and the posterior soft palate (PALATE, SOFT).Ligaments: Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile.Biglycan: A small leucine-rich proteoglycan found in a variety of tissues including CAPILLARY ENDOTHELIUM; SKELETAL MUSCLE; CARTILAGE; BONE; and TENDONS. The protein contains two glycosaminoglycan chains and is similar in structure to DECORIN.Blotting, Northern: Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.Abnormalities, MultipleIn Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Osteoblasts: Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.Scleroderma, Systemic: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.Maxilla: One of a pair of irregularly shaped bones that form the upper jaw. A maxillary bone provides tooth sockets for the superior teeth, forms part of the ORBIT, and contains the MAXILLARY SINUS.Elasticity: Resistance and recovery from distortion of shape.Chondrogenesis: The formation of cartilage. This process is directed by CHONDROCYTES which continually divide and lay down matrix during development. It is sometimes a precursor to OSTEOGENESIS.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Connective Tissue Cells: A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.Endostatins: Angiostatic proteins that are formed from proteolytic cleavage of COLLAGEN TYPE XVIII.Protein Conformation: The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).Elastic Modulus: Numerical expression indicating the measure of stiffness in a material. It is defined by the ratio of stress in a unit area of substance to the resulting deformation (strain). This allows the behavior of a material under load (such as bone) to be calculated.Chondroitin Sulfate Proteoglycans: Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).von Willebrand Factor: A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Solubility: The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Microscopy, Confocal: A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.Achilles Tendon: A fibrous cord that connects the muscles in the back of the calf to the HEEL BONE.Epidermolysis Bullosa Dystrophica: Form of epidermolysis bullosa characterized by atrophy of blistered areas, severe scarring, and nail changes. It is most often present at birth or in early infancy and occurs in both autosomal dominant and recessive forms. All forms of dystrophic epidermolysis bullosa result from mutations in COLLAGEN TYPE VII, a major component fibrils of BASEMENT MEMBRANE and EPIDERMIS.Granulation Tissue: A vascular connective tissue formed on the surface of a healing wound, ulcer, or inflamed tissue. It consists of new capillaries and an infiltrate containing lymphoid cells, macrophages, and plasma cells.Alkaline Phosphatase: An enzyme that catalyzes the conversion of an orthophosphoric monoester and water to an alcohol and orthophosphate. EC 3.1.3.1.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Photography, Dental: Photographic techniques used in ORTHODONTICS; DENTAL ESTHETICS; and patient education.Molecular Weight: The sum of the weight of all the atoms in a molecule.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Liver Cirrhosis, Experimental: Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.Mice, Inbred DBAEnzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Macromolecular Substances: Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
"Collagen induction therapy for the treatment of upper lip wrinkles". J Dermatolog Treat. 23 (2): 144-52. doi:10.3109/ ... It basically is a combination of classical medical microneedling by Dermaroller or DermaPen, both used in Collagen induction ...
They separate the cheeks from the upper lip. The term derives from Latin nasus for "nose" and labium for "lip". With ageing the ... Dermal fillings may be used to replace lost fats and collagen in this facial area. Epicanthal fold Nasalis muscle Burgess, ...
She goes on: "As we speak, my face is producing so much collagen, it has become a giant lip." Mr and Mrs McMuffin: we have ...
The mouth is fairly long and the upper lip furrows are longer than the lower ones. The teeth have a main pointed cusp and ... The first dorsal fin is approximately triangular and the trailing edge is fringed with bare, dark-coloured collagen rods known ...
Quantitative Analysis of Lip Appearance after V-Y Lip Augmentation. Jacono A. and Quatela VC. Arch Facial Plast Surg. 2004;6(3 ... Homologous Collagen Dispersion (Dermalogen) as a Dermal Filler: Persistence and Histology Compared with Bovine Collagen. ... A New Classification of Lip Zones to Customize Injectable Lip Augmentation. Jacono, AA. Arch Facial Plastic Surg. 2008 Jan-Feb ... Autologous Collagen Disperson (Autolegen) as a Dermal Filler. Sclafani A, Romo T, Parker A, McCormick S, Cocker R, and Jacono A ...
The result is collagen breakdown, infiltrate accumulation as well as collagen breakdown in the periodontal ligament and ... It provides for the movement of cheek and lips.[8] Periodontal Ligament[edit]. The periodontal ligament is the connective ... Collagen fibres bind the attached gingiva tightly to the underlying periodontium including the cementum and alveolar bone and ... it overlies the dentine layer of the tooth and provides attachment for the collagen fibres of the periodontal ligament. It also ...
Short ribs are cut from the lip of the roll. Some meat markets will sell cross-rib pot roast under the generic name "pot roast ... The chuck contains a lot of connective tissue, including collagen, which partially melts during cooking. Meat from the chuck is ...
... had received a collagen injection in her lips, which went awry and caused noticeable swelling. By the end of filming, however, ...
... as she faced media ridicule in 2002 when an allergic reaction to collagen lip implants left her with a severely swollen mouth. ...
A. cantonensis is a nematode roundworm with 3 outer protective collagen layers, and a simple stomal opening or mouth with no ... lips or buccal cavity leading to a fully developed gastrointestinal tract. Males have a small copulatory bursa at the posterior ...
A woman's lipstick (or collagen lip enhancement) attempts to take advantage of this fact by creating the illusion that a woman ... Chapped lips Cleft lip The Kiss, by Francesco Hayez, 1859 Lip balm Lipstick Pierced lips Rocky Horror Picture Show shadow ... Products designed for use on the lips include lipstick, lip gloss and lip balm. In most vertebrates, the lips are relatively ... Inflammation of the lips is termed cheilitis. This can be in several forms such as chapped lips (dry, peeling lips), angular ...
However, that collagen does not last very long and requires an allergy test, causing the patient to wait at least three weeks ... Lip plumper is a cosmetic product used to make lips appear fuller. These products work by irritating the skin of the lips with ... Lip augmentation is a type of cosmetic surgery or non-surgical procedure that aims to alter the appearance of the lips by ... This makes the lips swell slightly, temporarily creating the appearance of fuller lips. Suction pumps, a special device for ...
In the 1980s, when collagen, originally the principal filler for the lips, proved limited in effecting permanent correction, ... A technical variant of the gull-wing lip lift is the sub-nasal lip lift (bull-horn lip lift), which involves the removal of ... Lip Lift. Plastic and Reconstructive Surgery. 77(6);990-994. Fanous N. 1984 Correction of Thin Lips: "Lip Lift". Plastic and ... Incisions are also made below the lower lip to increase the projection of the vermilion of the lower lip. This gull-wing lip ...
These are a cheap, easy, and usually harmless alternative if compared to collagen, Restylane, Juvederm, or fat injections. They ... Lip gloss is often used when a person wants to have some color on their lips, but does not want an intense, solid lip color ... Basic lip gloss: adds basic shine to your lips without color. Colored lip gloss: adds a combination of color and shine. ... Lip gloss is also common for young women who don't like to wear makeup but have to attend a formal occasion. Lip gloss can be ...
April 2012). "Collagen induction therapy for the treatment of upper lip wrinkles". J Dermatolog Treat. 23 (2): 144-52. doi: ... Collagen induction therapy (CIT) also known as microneedling RF or skin needling is a cosmetic procedure that involves ...
Cleft lip palate deafness sacral lipoma Cleft lip palate dysmorphism Kumar type Cleft lip palate ectrodactyly Cleft lip palate ... hemolytic anemia Cold contact urticaria Cold urticaria Cole carpenter syndrome Coleman-Randall syndrome Colitis Collagen ... torti Cleft lip palate pituitary deficiency Cleft lip palate-tetraphocomelia Cleft lip with or without cleft palate Cleft lip ... hand absent tibia Cleft lip and palate malrotation cardiopathy Cleft lip and/or palate with mucous cysts of lower Cleft lip ...
2008). "Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts". ... Type XXVII collagen is related to the "fibrillar" class of collagens and may play a role in development of the skeleton. ... Collagen alpha-1 (XXVII) chain (COL27A1) is a protein that in humans is encoded by the COL27A1 gene. COL27A1 is a type XXVII ... Fibrillar collagens, such as COL27A1, compose one of the most ancient families of extracellular matrix molecules. They form ...
These collagen fibers are non degradable and the phagocytic activity is minimized. According to a recent cross sectional study ... vertical and circular palpable fibrous bands in and around the mouth or lips, resulting in a mottled, marble-like appearance of ... IFN-gamma is antifibrotic cytokine which alters collagen synthesis and helps in OSF. Colchicine tablets 0.5 mg twice a day ... intonation of voice Restriction of the movement of the soft palate A budlike shrunken uvula Thinning and stiffening of the lips ...
Collagen-elastine membrane, collagen-glycosaminoglycane (C-GAG) matrix, cross-linked collagen matrix Integra™ and Terudermis® ... Non-keratinized squamous epithelium covers the soft palate, lips, cheeks and the floor of the mouth. Keratinized squamous ... Collagen (mainly collagen type I) is often used as a scaffold because it is biocompatible, non-immunogenic and available. ... Collagen is the primary component of the extracellular matrix. Collagen scaffolds efficiently support fibroblast growth, which ...
This malformation can affect the lip and palate, or the palate only. A cleft palate can affect the mobility of the ... commonly cartilage or collagen) or type of soft palate lengthening procedure (i.e. VY palatoplasty). Conley SF, Gosain AK, ...
... and can be quite tough without long cooking times due to the high amount of collagen in the meat. Because of this, pork ... Bbq Your Way to Greatness with 575 Lip-Smackin Recipes from the Baron of Barbecue. ReadHowYouWant.com. p. 431. ISBN ...
Lip augmentation: alter the appearance of the lips by increasing their fullness through surgical enlargement with lip implants ... Fillers injections: collagen, fat, and other tissue filler injections, such as hyaluronic acid ... Cheiloplasty: surgical reconstruction of the lip. *Rhinoplasty ("nose job"): reshaping of the nose sometimes used to correct ... In 1793, François Chopart performed operative procedure on a lip using a flap from the neck. In 1814, Joseph Carpue ...
Peng Y.; Glattauer V.; Werkmeister J. A.; Ramshaw J. A. M. (2004). "Evaluation for collagen products for cosmetic application ... lip treatments, cleansers, after-sun lotion, and some soaps or body lotions. As hygroscopic moisturizers, humectants work by ... and collagen.[18] Glycerin is one of the most popular humectants used because it produces the desired result fairly frequently ...
... the corner of the mouth and the center of the upper lip. It is named from its great extent. "Latus" give the superlative " ... preserved mashed fasciae latae became FDA-approved as a tissue product designed to replace areas of lost fascia or collagen. ... lata as a sort of facial sling to support up the paralyzed face and loops the fascia lata around the center of the lower lip, ...
Amelia cleft lip palate hydrocephalus iris coloboma Amelia facial dysmorphism Amelia X linked Amelogenesis Amelogenesis ... Alpers disease Alpha 1-antitrypsin deficiency Alpha-2 deficient collagen disease Alpha-ketoglutarate dehydrogenase deficiency ... sporadic Aniridia Anisakiasis Ankle defects short stature Ankyloblepharon ectodermal defects cleft lip palate Ankyloblepharon ... brachydactyly type B Anonychia onychodystrophy Anophthalia Anophthalia pulmonary hypoplasia Anophthalmia Anophthalmia cleft lip ...
Congenital lip pit. *Congenital malformations of the dermatoglyphs. *Congenital preauricular fistula. *Congenital smooth muscle ...
Boos CJ, Lip GY, Blann AD. Circulating endothelial cells in cardiovascular disease. J Am Coll Cardiol. 2006;48(8):1538-47. ... The combination of vWF and collagen causes a conformational change in the site of vWF binding to factor VIII, which promotes ... Boos CJ, Balakrishnan B, Blann AD, Lip GY. The relationship of circulating endothelial cells to plasma indices of endothelial ... Boos CJ, Balakrishnan B, Jessani S, Blann AD, Lip GY. Effects of percutaneous coronary intervention on peripheral venous blood ...
This vegan collagen lip treatment to deliver fuller, younger-looking lips in as few as 10 days. ... Shop Algenists GENIUS Liquid Collagen Lip at Sephora. ... AlgenistGENIUS Liquid Collagen Lip. SIZE 0.34 oz/ 10 mL•ITEM ... A vegan collagen lip treatment to deliver long-lasting benefits for fuller, younger-looking lips in as few as 10 days.. If you ... This unique dual-phase lip treatment suspends botanical lip enhancers and hundreds of beads of microalgae oil in collagen water ...
A clear lip gloss enriched with skincare ingredients to create fuller-looking lips. ... Shop Charlotte Tilburys Collagen Lip Bath Gloss at Sephora. ... Start by outlining your lips using the Lip Cheat Lip Liners ( ... Get fresh lips in a flash with this high-shine gloss that helps to put moisture back into the lips for a healthier-looking lip ... What it is: A clear lip gloss enriched with skincare ingredients to create fuller-looking lips.. Ingredient Callouts: Free of ...
Simpson jocelyn wildenstein Lara Flynn Boyle Lil Kim Lindsay Lohan lip augmentation lip collagen lip filler lip fillers lip ... Tags: breast implants, lip collagen, Orit Fux · Posted in: Scary Celebrities Tara Reid - bee stung lips make me look young, ... Tags: breast augmentation, Casey Johnson, lip collagen, lip injections, Tila Tequila · Posted in: Casey Johnson, Tila Tequila ... Tags: lip collagen, Olivia Newton-John, trout pout · Posted in: Olivia Newton-John ...
Beyond providing Skin Deep® as an educational tool for consumers, EWG offers its EWG VERIFIED™ mark as a quick and easily identifiable way of conveying personal care products that meet EWGs strict health criteria. Before a company can use EWG VERIFIEDTM on such products, the company must show that it fully discloses the products ingredients on their labels or packaging, they do not contain EWG ingredients of concern, and are made with good manufacturing practices, among other criteria. Note that EWG receives licensing fees from all EWG VERIFIED member companies that help to support the important work we do. Learn more , Legal Disclaimer ...
Add the Jeecol PMA-3 and mineral oil and heat to 75-80°C. Add in the Jeenates, Jeechem TISC, Jeecide CAP-2 and mix until uniform. Cool the batch to 55-60°C and add in the vitamin E. Premix the Jeechem FS-103, water and phytocollagen and add to the batch. Add in the flavor. Pour product into stick containers and let harden ...
The effectiveness of collagen lip injections varies. Visit HowStuffWorks to learn about the effectiveness of collagen lip ... After a few sessions of fat injections, youll move on to collagen. The fat adds volume to your lips, while the collagen gives ... Fat and Collagen. Sometimes combining collagen with other treatments can be the most effective way to achieve the look you want ... Some human-derived collagen even comes from deceased donors [source: Shuman]. The choice is yours: Should your collagen ...
Lip Cheat Liner id1064061] and fill in for long-lasting color Use the heart-shaped applicator to wash gloss over your upper ... Soluble Collagen, Ricinus Communis (Castor) Seed Oil, Sorbitan Isostearate, Mica, Tocopherol, Portulaca Pilosa Extract, Sodium ... and lower lips 7.9ml/ 0.26oz.Ingredients: Polybutene, Octyldodecanol, Dicaprylyl Carbonate, Diisostearyl Malate, ... Collagen Lip Bath enhances the gloss, pigment, and plumpness of your pout. Tinted a deep pink Rosy Glow, it douses your lips ...
... lip mask rehabilitates aging, lined, and exhausted skin and saturates skin with much needed moisture for up to 72 hours. ... lip mask rehabilitates aging, lined, and exhausted skin and saturates skin with much needed moisture for up to 72 hours. ... Collagen Rehab. Face + lip mask to rehabilitate aging, lined and exhausted skin ... 5 plant collagen amino acids. This 5 plant blend of rice extract, soy bean, carrot, quinoa and red ginseng deliver a complex of ...
These nourishing crème glosses have been expertly formulated to support collagen production, encouraging a boost of volume for ... p,Wrap lips in a hydrating veil of high shine gloss enriched with a collagen boosting complex. ... Youre reviewing: Collagen Boost Lip Lacquer - Intimate. How do you rate this product? *. QUALITY (FROM 1 LOW - 5 HIGH) ... Wrap lips in a hydrating veil of high shine gloss enriched with a collagen boosting complex. These nourishing crème glosses ...
Buy Rodial Collagen Boost Lip Lacquer 0.2oz (Various Shades) online at SkinStore with free shipping! We have a great range of ... Apply your desired shade of Lip Lacquer all over the lips for a hydrating, high shine wet look lip. ... Apply your desired shade of Lip Lacquer all over the lips for a hydrating, high shine wet look lip. ... Wrap lips in a hydrating veil of high shine gloss enriched with a collagen boosting complex. These nourishing crème glosses ...
... - ... A moisturizing treatment gloss infused with revolutionary technology to plump lips instantly., ... Formerly called Fusion Beauty LipFusion Collagen Lip Plump - Goddess.. Usage. Apply as needed to moisturize and plump the lips ... of the lip tissue. The result is fuller, smoother, perfectly plumped lips in seconds. Results can last for up to 48 hours. ...
LipFusion Lip Plump Color Shine is perfect on its own or as a sheer color gloss over lip color. Tip: For a full-out, perfectly- ... FusionBeauty LipFusion Micro-Injected Collagen Lip Plump Color Shine, Fresh (old formulation). See all: Fusion Beauty, Inc. ... EWGs rating for FusionBeauty LipFusion Micro-Injected Collagen Lip Plump Color Shine, Fresh (old formulation) is 5. ... EWG scientists reviewed FusionBeauty LipFusion Micro-Injected Collagen Lip Plump Color Shine, Fresh (old formulation) for ...
For an added pop, apply Collagen Boost Lip Lacquer in shade Champagne Showers to the centre of the lips for a 3D effect. ... Youre reviewing: Collagen Boost Lip Lacquer - Stripped. How do you rate this product? *. QUALITY (FROM 1 LOW - 5 HIGH) ... Wrap lips in a hydrating veil of high shine gloss enriched with a collagen boosting complex. These nourishing crème glosses ... Wrap lips in a hydrating veil of high shine gloss enriched with a collagen boosting complex. These nourishing crème glosses ...
Fusion Beauty LipFusion XL Micro-Injected Collagen Lip Plump Customer Reviews from SkinStore. Read genuine and unbiased product ... Fusion Beauty LipFusion XL Micro-Injected Collagen Lip Plump Customer Reviews. USD 50.0 $50.00 ... Ok, so its supposed to be a lip plumper and it does help with that...but this product keeps lips incredibly healthy in my ... They last forever and are unreal at healing chapped lips.The second I feel my lips becoming chapped, I put it on overnight and ...
... and rehydrate to instantly plump and smooth lips, Fusion Beauty LipFusion XL 2X Micro Collagen + HA Advanced Lip Plump - ... It transforms the unique micro-injected collagen technology into the most advanced plumping power found in a lip treatment. ... Patented dehydrated marine collagen-filling spheres penetrate skins surface on contact, then seek out bodys natural water, ... This non-injectable lip volumizing therapy combines two times the pure active collagen of LipFusions original plumpers with ...
Lips masks hydrate and plump chapped lips. KNCs All Natural Collagen Infused Lip Mask contains collagen, rose flower oil and ... Despite working my way through mountains of lip balms, lip scrubs and lip oils that pass through the Stylist desk, Im yet to ... KNC All Natural Collagen Infused Lip masks, £48.12 for a pack of 10, available at net-a-porter.com ... There are lots to choose from but after a bit of research, I settled on KNCs All Natural Collagen Infused Lip Masks, £48.12 ...
Buy SooAe Collagen Hydrogel Lip Patch 10g at Superdrug.com plus much more from SooAe . Free standard delivery Order and ... Home , Make Up , Lips , Lip Kits , SooAe Collagen Hydrogel Lip Patch 10g. ... Soothing Moisture: Hydrolyzed Collagen, Licorice Root and Green Tea extracts instantly soothe and restore moisture to lips ... Soothing Moisture: Hydrolyzed Collagen, Licorice Root and Green Tea extracts instantly soothe and restore moisture to lips ...
LOreal Paris Revitalift Collagen Lip Treatment, Anti-Aging. Read more LOreal Paris product reviews at Total Beauty. ...
The perfect solution for chapped dry lips, removing dead skin cells and wrinkle lines while balancing skin tone. Deal includes ... cracked and wrinkled lips. The peel off design is simple to ease and very effective. To use simply cleanse and thoroughly dry ... The Gold Collagen Mask is the premiere choice for relieving dry, ... The Gold Collagen Mask is the premiere choice for relieving dry ... The perfect solution for chapped dry lips, removing dead skin cells and wrinkle lines while balancing skin tone. Deal includes ...
Collagen Active Lip-Gloss, Lip Plumper. Read more Dior product reviews at Total Beauty. ... Reviews / Face / Lip Plumper Dior Addict Lip Maximizer - Collagen Active Lip-Gloss ... lip Maximizer CD collagen activ. totally addictive, feel so nice to put on and I can see my lips are fuller after using it ... 9 Lip Glosses Were Obsessed With Exclusively from the editors at Total Beauty ...
Collagen Kiss Collagen-Infused Lip Mask. Hydrating lip mask infused with Vitamin C, E, & collagen to leave lips feeling smooth ... a single-use lip mask that will leave your lips looking fuller and plumper. Our lip treatment is collagen-infused and packed ... "Collagen Kiss is the answer to the perfect pout. You get bouncy lips that are picture-perfect." ... A Lip Mask With Kissable Results Relieve chapped pouts with Neutrogena Collagen Kiss, ...
Collagen Kiss Collagen-Infused Lip Mask. Hydrating lip mask infused with Vitamin C, E, & collagen to leave lips feeling smooth ... a single-use lip mask that will leave your lips looking fuller and plumper. Our lip treatment is collagen-infused and packed ... www.neutrogena.com/makeup/makeup-lips/neutrogena-collagen-kiss-lip-mask/6819579.html $3.97 0.10 OZ ... "Collagen Kiss is the answer to the perfect pout. You get bouncy lips that are picture-perfect." ...
... your lips. Algenists GENIUS Liquid Collagen Lip wants to smooth and plump your lips with a vegan formula-and we tapped ... wellness blogger Bianca Klotsman to try the collagen lip treatment. Find out what she thought. ... Makes lips visibly fuller (for longer). A natural side effect of supremely hydrated lips-thanks to the collagen-packed ... "The collagen locks in throughout the night allowing more supple looking lips and preparing lips for any gloss or lipstick ...
A lip rejuvenating lip treatment to smooth, nourishing and restore natural volume. ... Dennis Gross Hyaluronic Marine Collagen Lip Cushion at b-glowing.com. ... Dennis Gross have given us the gift of a powerful, non-invasive lip treatment. Enter Hyaluronic Marine Collagen Lip Cushion. ... Apply throughout the day as needed on clean lips as well as above and around lip border. Perfect to wear alone for a satin ...
  • EWG scientists reviewed FusionBeauty LipFusion Micro-Injected Collagen Lip Plump Color Shine, Fresh (old formulation) for safety according to the methodology outlined in our Skin Deep Cosmetics Database. (ewg.org)
  • EWG's rating for FusionBeauty LipFusion Micro-Injected Collagen Lip Plump Color Shine, Fresh (old formulation) is 5. (ewg.org)
  • A vegan collagen lip treatment to deliver long-lasting benefits for fuller, younger-looking lips in as few as 10 days. (sephora.com)
  • To find out firsthand whether the lip-centric benefits were too good to be true, we tapped wellness blogger and h olistic nutritionist Bianca Klotsman to give us the scoop after using the vegan formula for 10 days. (wellandgood.com)
  • Collagen Support Complex: booster hudens forsvar og udfylder huden, så rynker minimeres. (hellethorup.dk)
  • Our VoluMax Complex stimulates the production of these essential proteins to reinvigorate lip plumpness, definition, and structure. (eilujbeauty.com)