Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.Colitis, Ulcerative: Inflammation of the COLON that is predominantly confined to the MUCOSA. Its major symptoms include DIARRHEA, rectal BLEEDING, the passage of MUCUS, and ABDOMINAL PAIN.Colitis, Ischemic: Inflammation of the COLON due to colonic ISCHEMIA resulting from alterations in systemic circulation or local vasculature.Colitis, Microscopic: A condition characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. This syndrome was first described in 1980 by Read and associates. Subtypes include COLLAGENOUS COLITIS and LYMPHOCYTIC COLITIS. Both have similar clinical symptoms and are distinguishable only by histology.Dextran Sulfate: Long-chain polymer of glucose containing 17-20% sulfur. It has been used as an anticoagulant and also has been shown to inhibit the binding of HIV-1 to CD4-POSITIVE T-LYMPHOCYTES. It is commonly used as both an experimental and clinical laboratory reagent and has been investigated for use as an antiviral agent, in the treatment of hypolipidemia, and for the prevention of free radical damage, among other applications.Colitis, Collagenous: A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show larger-than-normal band of subepithelial COLLAGEN.Colon: The segment of LARGE INTESTINE between the CECUM and the RECTUM. It includes the ASCENDING COLON; the TRANSVERSE COLON; the DESCENDING COLON; and the SIGMOID COLON.Trinitrobenzenesulfonic Acid: A reagent that is used to neutralize peptide terminal amino groups.Colitis, Lymphocytic: A subtype of MICROSCOPIC COLITIS, characterized by chronic watery DIARRHEA of unknown origin, a normal COLONOSCOPY but abnormal histopathology on BIOPSY. Microscopic examination of biopsy samples taken from the COLON show infiltration of LYMPHOCYTES in the superficial EPITHELIUM and the underlying connective tissue (lamina propria).Crohn Disease: A chronic transmural inflammation that may involve any part of the DIGESTIVE TRACT from MOUTH to ANUS, mostly found in the ILEUM, the CECUM, and the COLON. In Crohn disease, the inflammation, extending through the intestinal wall from the MUCOSA to the serosa, is characteristically asymmetric and segmental. Epithelioid GRANULOMAS may be seen in some patients.Intestinal Mucosa: Lining of the INTESTINES, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. In the SMALL INTESTINE, the mucosa is characterized by a series of folds and abundance of absorptive cells (ENTEROCYTES) with MICROVILLI.Inflammatory Bowel Diseases: Chronic, non-specific inflammation of the GASTROINTESTINAL TRACT. Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS.Mesalamine: An anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY BOWEL DISEASE. It is considered to be the active moiety of SULPHASALAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed)Rectum: The distal segment of the LARGE INTESTINE, between the SIGMOID COLON and the ANAL CANAL.Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)Peroxidase: A hemeprotein from leukocytes. Deficiency of this enzyme leads to a hereditary disorder coupled with disseminated moniliasis. It catalyzes the conversion of a donor and peroxide to an oxidized donor and water. EC 1.11.1.7.Gastrointestinal Agents: Drugs used for their effects on the gastrointestinal system, as to control gastric acidity, regulate gastrointestinal motility and water flow, and improve digestion.Colectomy: Excision of a portion of the colon or of the whole colon. (Dorland, 28th ed)Proctocolectomy, Restorative: A surgical procedure involving the excision of the COLON and RECTUM and the formation of an ILEOANAL RESERVOIR (pouch). In patients with intestinal diseases, such as ulcerative colitis, this procedure avoids the need for an OSTOMY by allowing for transanal defecation.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Colonoscopy: Endoscopic examination, therapy or surgery of the luminal surface of the colon.Dysentery, Amebic: DYSENTERY caused by intestinal amebic infection, chiefly with ENTAMOEBA HISTOLYTICA. This condition may be associated with amebic infection of the LIVER and other distant sites.Ileostomy: Surgical creation of an external opening into the ILEUM for fecal diversion or drainage. This replacement for the RECTUM is usually created in patients with severe INFLAMMATORY BOWEL DISEASES. Loop (continent) or tube (incontinent) procedures are most often employed.Administration, Rectal: The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.Enterocolitis, Pseudomembranous: An acute inflammation of the INTESTINAL MUCOSA that is characterized by the presence of pseudomembranes or plaques in the SMALL INTESTINE (pseudomembranous enteritis) and the LARGE INTESTINE (pseudomembranous colitis). It is commonly associated with antibiotic therapy and CLOSTRIDIUM DIFFICILE colonization.Pouchitis: Acute INFLAMMATION in the INTESTINAL MUCOSA of the continent ileal reservoir (or pouch) in patients who have undergone ILEOSTOMY and restorative proctocolectomy (PROCTOCOLECTOMY, RESTORATIVE).Mice, Inbred C57BLEnterocolitis: Inflammation of the MUCOSA of both the SMALL INTESTINE and the LARGE INTESTINE. Etiology includes ISCHEMIA, infections, allergic, and immune responses.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.Colonic Pouches: Sacs or reservoirs created to function in place of the COLON and/or RECTUM in patients who have undergone restorative proctocolectomy (PROCTOCOLECTOMY, RESTORATIVE).Acetic Acid: Product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed)Intestines: The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.Probiotics: Live microbial DIETARY SUPPLEMENTS which beneficially affect the host animal by improving its intestinal microbial balance. Antibiotics and other related compounds are not included in this definition. In humans, lactobacilli are commonly used as probiotics, either as single species or in mixed culture with other bacteria. Other genera that have been used are bifidobacteria and streptococci. (J. Nutr. 1995;125:1401-12)Interleukin-10: A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.Cytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Cecum: The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.Citrobacter rodentium: A species of gram-negative bacteria in the genus CITROBACTER, family ENTEROBACTERIACEAE. As an important pathogen of laboratory mice, it serves as a model for investigating epithelial hyperproliferation and tumor promotion. It was previously considered a strain of CITROBACTER FREUNDII.Ileitis: Inflammation of any segment of the ILEUM and the ILEOCECAL VALVE.Feces: Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.Helicobacter hepaticus: A species of HELICOBACTER that colonizes the CECUM and COLON of several strains of MICE, and is associated with HEPATITIS and carcinogenesis.Mice, Inbred BALB CAnti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Megacolon, Toxic: An acute form of MEGACOLON, severe pathological dilatation of the COLON. It is associated with clinical conditions such as ULCERATIVE COLITIS; CROHN DISEASE; AMEBIC DYSENTERY; or CLOSTRIDIUM ENTEROCOLITIS.Ileum: The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.Oxazolone: Immunologic adjuvant and sensitizing agent.Biopsy: Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.Clostridium difficile: A common inhabitant of the colon flora in human infants and sometimes in adults. It produces a toxin that causes pseudomembranous enterocolitis (ENTEROCOLITIS, PSEUDOMEMBRANOUS) in patients receiving antibiotic therapy.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.Colon, Sigmoid: A segment of the COLON between the RECTUM and the descending colon.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Sigmoidoscopy: Endoscopic examination, therapy or surgery of the sigmoid flexure.Colonic Diseases: Pathological processes in the COLON region of the large intestine (INTESTINE, LARGE).Proctitis: INFLAMMATION of the MUCOUS MEMBRANE of the RECTUM, the distal end of the large intestine (INTESTINE, LARGE).Intestine, Large: A segment of the LOWER GASTROINTESTINAL TRACT that includes the CECUM; the COLON; and the RECTUM.Cholangitis, Sclerosing: Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.Mucous Membrane: An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.Azathioprine: An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)Colonic Neoplasms: Tumors or cancer of the COLON.Proctocolitis: Inflammation of the RECTUM and the distal portion of the COLON.Acute Disease: Disease having a short and relatively severe course.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Dinitrofluorobenzene: Irritants and reagents for labeling terminal amino acid groups.Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.Bacterial Translocation: The passage of viable bacteria from the GASTROINTESTINAL TRACT to extra-intestinal sites, such as the mesenteric lymph node complex, liver, spleen, kidney, and blood. Factors that promote bacterial translocation include overgrowth with gram-negative enteric bacilli, impaired host immune defenses, and injury to the INTESTINAL MUCOSA resulting in increased intestinal permeability. Bacterial translocation from the lung to the circulation is also possible and sometimes accompanies MECHANICAL VENTILATION.Mesentery: A layer of the peritoneum which attaches the abdominal viscera to the ABDOMINAL WALL and conveys their blood vessels and nerves.Clostridium Infections: Infections with bacteria of the genus CLOSTRIDIUM.Collagen Diseases: Historically, a heterogeneous group of acute and chronic diseases, including rheumatoid arthritis, systemic lupus erythematosus, progressive systemic sclerosis, dermatomyositis, etc. This classification was based on the notion that "collagen" was equivalent to "connective tissue", but with the present recognition of the different types of collagen and the aggregates derived from them as distinct entities, the term "collagen diseases" now pertains exclusively to those inherited conditions in which the primary defect is at the gene level and affects collagen biosynthesis, post-translational modification, or extracellular processing directly. (From Cecil Textbook of Medicine, 19th ed, p1494)CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Ulcer: A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.Mucin-2: A gel-forming mucin found predominantly in SMALL INTESTINE and variety of mucous membrane-containing organs. It provides a protective, lubricating barrier against particles and infectious agents.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.

Responses of human intestinal microvascular endothelial cells to Shiga toxins 1 and 2 and pathogenesis of hemorrhagic colitis. (1/2654)

Endothelial damage is characteristic of infection with Shiga toxin (Stx)-producing Escherichia coli (STEC). Because Stx-mediated endothelial cell damage at the site of infection may lead to the characteristic hemorrhagic colitis of STEC infection, we compared the effects of Stx1 and Stx2 on primary and transformed human intestinal microvascular endothelial cells (HIMEC) to those on macrovascular endothelial cells from human saphenous vein (HSVEC). Adhesion molecule, interleukin-8 (IL-8), and Stx receptor expression, the effects of cytokine activation and Stx toxins on these responses, and Stx1 and Stx2 binding kinetics and bioactivity were measured. Adhesion molecule and IL-8 expression increased in activated HIMEC, but these responses were blunted in the presence of toxin, especially in the presence of Stx1. In contrast to HSVEC, unstimulated HIMEC constitutively expressed Stx receptor at high levels, bound large amounts of toxin, were highly sensitive to toxin, and were not further sensitized by cytokines. Although the binding capacities of HIMEC for Stx1 and Stx2 were comparable, the binding affinity of Stx1 to HIMEC was 50-fold greater than that of Stx2. Nonetheless, Stx2 was more toxic to HIMEC than an equivalent amount of Stx1. The decreased binding affinity and increased toxicity for HIMEC of Stx2 compared to those of Stx1 may be relevant to the preponderance of Stx2-producing STEC involved in the pathogenesis of hemorrhagic colitis and its systemic complications. The differences between primary and transformed HIMEC in these responses were negligible. We conclude that transformed HIMEC lines could represent a simple physiologically relevant model to study the role of Stx in the pathogenesis of hemorrhagic colitis.  (+info)

Tissue distribution of dextran sulfate sodium (DSS) in the acute phase of murine DSS-induced colitis. (2/2654)

In the present study, we examined histochemically the tissue distribution of dextran sulfate sodium (DSS) in the acute phase of murine colitis induced by administering DSS in the drinking water. DSS was mainly observed in the Kupffer cells of the liver, in the macrophages of the mesenteric lymph node (MLN) and in the lamina propria of the large intestine after administration of DSS. We followed the time course of DSS distribution and found that DSS, which was considered as a large and negatively charged molecule that can not easily cross membranes, was distributed in the liver, the MLN, and the large intestine 1 day after the start of administration of DSS.  (+info)

Protein kinase C mediates experimental colitis in the rat. (3/2654)

Protein kinase C (PKC) plays an important role in the cell signal transduction of many physiological processes. In contrast to these physiological responses, increases in PKC activity have also been associated with inflammatory disease states, including ulcerative colitis. The objective of this study was to examine the role of PKC as a causative mediator in initiation of experimentally induced colitis in the rat. Colitis was induced in rats by intrarectal (0.6 ml) instillation of 2,4,6-trinitrobenzenesulfonic acid (TNBS; 75 mg/kg in 50% ethanol) or the PKC activator phorbol 12-myristate 13-acetate (PMA; 1.5-3.0 mg/kg in 20% ethanol). Gross and histological mucosal damage, mucosal neutrophil infiltration, mucosal PKC activity, and PKC protein content for PKC isoforms alpha, beta, delta, and epsilon were assessed 2 h to 14 days after an inflammatory challenge. Both PKC activity and mucosal injury increased significantly within 4 h of TNBS treatment. PKC activity was maximal at 7 days and declined at 14 days, whereas mucosal damage became maximal at 1 day and declined after 7 days. In contrast, neutrophil infiltration as assessed by myeloperoxidase activity only increased 12 h after TNBS treatment, became maximal 1 day after TNBS administration, and declined thereafter. PKCbeta, -delta, and -epsilon were increased in response to TNBS, whereas PKCalpha protein content was decreased. The PKC antagonists staurosporine and GF-109203X (25 ng/kg iv) reduced TNBS-induced changes in mucosal PKC activity and the degree of mucosal damage. In contrast, neutropenia induced by antineutrophil serum treatment did not significantly affect the degree of injury or mucosal PKC activity. Furthermore, activation of mucosal PKC activity with PMA also induced mucosal damage, which was also inhibited by pretreatment with a PKC antagonist. In conclusion, these results suggest that increases in PKC activity play a causative role in TNBS-induced colitis. The PKC-mediated response to TNBS does not appear to involve neutrophil infiltration.  (+info)

Prolonged colonic epithelial hyporesponsiveness after colitis: role of inducible nitric oxide synthase. (4/2654)

Colonic epithelial secretion is an important host defense mechanism. We examined whether a bout of colitis would produce long-lasting changes in epithelial function that persisted after resolution of mucosal inflammation. Colitis was induced in rats with intracolonic trinitrobenzenesulfonic acid. Six weeks later, colonic damage and inducible nitric oxide synthase (iNOS) mRNA expression and activity were measured. Segments of distal colon were mounted in Ussing chambers for measurement of permeability and responsiveness to secretory stimuli. Basal electrolyte transport parameters and permeability were not different from untreated controls. Despite normal macroscopic and histological appearance, secretory responses to electrical field stimulation (EFS), isobutylmethylxanthine (IBMX), and carbachol were significantly depressed (by 60-70%) relative to controls. iNOS mRNA expression and enzyme activity were significantly elevated. Dexamethasone reversed epithelial hyporesponsiveness and significantly reduced iNOS mRNA expression. A selective iNOS inhibitor normalized the secretory responses to EFS and IBMX but not to carbachol. These data suggest that ongoing synthesis of nitric oxide by iNOS contributes to chronic suppression of epithelial secretory function after episodes of colitis.  (+info)

Neurotensin is a proinflammatory neuropeptide in colonic inflammation. (5/2654)

The neuropeptide neurotensin mediates several intestinal functions, including chloride secretion, motility, and cellular growth. However, whether this peptide participates in intestinal inflammation is not known. Toxin A, an enterotoxin from Clostridium difficile, mediates pseudomembranous colitis in humans. In animal models, toxin A causes an acute inflammatory response characterized by activation of sensory neurons and intestinal nerves and immune cells of the lamina propria. Here we show that neurotensin and its receptor are elevated in the rat colonic mucosa following toxin A administration. Pretreatment of rats with the neurotensin receptor antagonist SR-48, 692 inhibits toxin A-induced changes in colonic secretion, mucosal permeability, and histologic damage. Exposure of colonic explants to toxin A or neurotensin causes mast cell degranulation, which is inhibited by SR-48,692. Because substance P was previously shown to mediate mast cell activation, we examined whether substance P is involved in neurotensin-induced mast cell degranulation. Our results show that neurotensin-induced mast cell degranulation in colonic explants is inhibited by the substance P (neurokinin-1) receptor antagonist CP-96,345, indicating that colonic mast activation in response to neurotensin involves release of substance P. We conclude that neurotensin plays a key role in the pathogenesis of C. difficile-induced colonic inflammation and mast cell activation.  (+info)

Expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in acute and chronic inflammation. (6/2654)

The objective of this study was to quantify, in vivo, constitutive and tumor necrosis factor alpha (TNF-alpha)-enhanced expression of mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in different tissues from healthy wild-type mice (C57BL/6) as well as interleukin-10 (IL-10)-deficient mice with and without active colitis. Using the dual radiolabel monoclonal antibody technique, we found substantial constitutive expression of MAdCAM-1 in the intestine, colon, and mesenteric lymph nodes. MAdCAM-1 expression in these tissues was significantly enhanced, in a time-dependent manner, by systemic administration of TNF-alpha. Maximum surface expression was observed at 18 h after TNF-alpha administration and remained significantly elevated at 48 h post-TNF-alpha injection. No significant constitutive nor TNF-alpha-induced expression of MAdCAM-1 was detected in skeletal muscle, brain, or heart. In IL-10-deficient (IL-10 k/o) mice with no clinical or histological evidence of colitis, constitutive and TNF-alpha-induced expression of MAdCAM-1 in the intestine, cecum, and colon was not different from those values obtained with healthy wild-type controls. IL-10-deficient mice with active colitis exhibited a four- to fivefold greater expression of MAdCAM-1 in the cecum and colon compared with their healthy controls or to IL-10 k/o mice with no evidence of colitis. Taken together, these data demonstrate that TNF-alpha enhances surface expression of MAdCAM-1 in intestinal and colonic tissues to the same extent in both wild-type and IL-10 k/o mice with no colonic inflammation, whereas IL-10 k/o mice with active colitis exhibited a profound up-regulation of MAdCAM-1 in the colon.  (+info)

A novel urease-negative Helicobacter species associated with colitis and typhlitis in IL-10-deficient mice. (7/2654)

A spiral-shaped bacterium with bipolar, single-sheathed flagella was isolated from the intestines of IL-10 (interleukin-10)-deficient (IL-10(-/-)) mice with inflammatory bowel disease. The organism was microaerobic, grew at 37 and 42 degrees C, and was oxidase and catalase positive but urease negative. On the basis of 16S rRNA gene sequence analysis and biochemical and phenotypic criteria, the organism is classified as a novel helicobacter. Cesarean section-rederived IL-10(-/-) mice without helicobacter infection did not have histological evidence of intestinal inflammation. However, helicobacter-free IL-10(-/-), SCID/NCr, and A/JNCr mice experimentally inoculated with the novel urease-negative Helicobacter sp. developed variable degrees of inflammation in the lower intestine, and in immunocompetent mice, the experimental infection was accompanied by a corresponding elevated immunoglobulin G antibody response to the novel Helicobacter sp. antigen. These data support other recent studies which demonstrate that multiple Helicobacter spp. in both naturally and experimentally infected mice can induce inflammatory bowel disease. The mouse model of helicobacter-associated intestinal inflammation should prove valuable in understanding how specific microbial antigens influence a complex disease process.  (+info)

Immediate-early gene expression in the inferior mesenteric ganglion and colonic myenteric plexus of the guinea pig. (8/2654)

Activation of neurons in the inferior mesenteric ganglion (IMG) was assessed using c-fos, JunB, and c-Jun expression in the guinea pig IMG and colonic myenteric plexus during mechanosensory stimulation and acute colitis in normal and capsaicin-treated animals. Intracolonic saline or 2% acetic acid was administered, and mechanosensory stimulation was performed by passage of a small (0.5 cm) balloon either 4 or 24 hr later. Lower doses of capsaicin or vehicle were used to activate primary afferent fibers during balloon passage. c-Jun did not respond to any of the stimuli in the study. c-fos and JunB were absent from the IMG and myenteric plexus of untreated and saline-treated animals. Acetic acid induced acute colitis by 4 hr, which persisted for 24 hr, but c-fos was found only in enteric glia in the myenteric plexus and was absent from the IMG. Balloon passage induced c-fos and JunB in only a small subset of IMG neurons and no myenteric neurons. However, balloon passage induced c-fos and JunB in IMG neurons (notably those containing somatostatin) and the myenteric plexus of acetic acid-treated animals. After capsaicin treatment, c-fos and JunB induction by balloon passage was inhibited in the IMG, but there was enhanced c-fos expression in the myenteric plexus. c-fos and JunB induction by balloon stimulation was also mimicked by acute activation of capsaicin-sensitive nerves. These data suggest that colitis enhances reflex activity of the IMG by a mechanism that involves activation of both primary afferent fibers and the myenteric plexus.  (+info)

*Colitis

Lymphocytic colitis Collagenous colitis Diversion colitis Chemical colitis Ischemic colitis Infectious colitis A subtype of ... Indeterminate colitis is the classification for colitis that has features of both Crohn's disease and ulcerative colitis. ... Indeterminate colitis' behaviour is usually closer to ulcerative colitis than Crohn's disease. Atypical colitis is a phrase ... Crohn's disease - a type of IBD that often leads to colitis. Microscopic colitis - a colitis is diagnosed by microscopic ...

*Ulcerative colitis

... at Curlie (based on DMOZ) MedlinePlus ulcerative colitis page Ulcerative colitis information page at Crohn's ... Ulcerative colitis at eMedicine Walmsley, R S; Ayres, R C S; Pounder, R E; Allan, R N (1998). "A simple clinical colitis ... One study of isotretinoin found a small increase in the rate of ulcerative colitis. Ulcerative colitis is an autoimmune disease ... A diagnosis of ulcerative colitis may not occur until the onset of intestinal manifestations, however. Ulcerative colitis is ...

*Cytomegalovirus colitis

... , also known as CMV colitis, is an inflammation of the colon Causes The infection is spread by saliva, ... Severe CMV colitis may lead a colectomy. The systemic use of corticosteroids in the context of inflammatory bowel disease. ... The diagnosis of CMV colitis is based on serology, CMV antigen testing and colonscopy with biopsy. Clinical suspicion should be ... Although it is known that CMV colitis is almost always caused by reactivation of latent CMV infection in immunocompromised ...

*Diversion colitis

... is an inflammation of the colon which can occur as a complication of ileostomy or colostomy, often occurring ... In many milder cases after ileostomy or colostomy, diversion colitis is left untreated and disappears naturally. If treatment ... Geraghty JM, Talbot IC (September 1991). "Diversion colitis: histological features in the colon and rectum after defunctioning ...

*Lymphocytic colitis

... are lymphocytic colitis and collagenous colitis two subtypes of the same disease - microscopic colitis?". Aliment Pharmacol ... Colitis Münch A, Aust D, Bohr J, Bonderup O, Fernández Bañares F, Hjortswang H, et al. (2012). "Microscopic colitis: Current ... Lymphocytic colitis is a subtype of microscopic colitis, a condition characterized by chronic non-bloody watery diarrhea. The ... Lymphocytic colitis was first described in 1989. No definite cause has been determined. Some reports have implicated long-term ...

*Collagenous colitis

Colitis Lymphocytic colitis Inflammatory bowel disease Ulcerative colitis Park, Tina; Cave, David; Marshall, Christopher (2015- ... Yen E. F.; Pardi D. S. (May 2011). "Microscopic Colitis - Lymphocytic, Collagenous and 'Mast Cell' Colitis". Alimentary ... Chande N, Driman DK, Reynolds RP (March 2005). "Collagenous colitis and lymphocytic colitis: patient characteristics and ... lymphocytic colitis. Microscopic colitis causes chronic watery diarrhea with greater than 10 bowel movements per day. Some ...

*Microscopic colitis

... ulcerative colitis and infectious colitis. Incidence and prevalence of microscopic colitis nears those of ulcerative colitis ... Collagenous colitis was recognised earlier, in 1976. Colitis Inflammatory bowel disease Ulcerative colitis Münch A, Aust D, ... Microscopic colitis refers to two related medical conditions which cause diarrhea: collagenous colitis and lymphocytic colitis ... are lymphocytic colitis and collagenous colitis two subtypes of the same disease - microscopic colitis?". Aliment Pharmacol ...

*Ischemic colitis

Symptoms of ischemic colitis vary depending on the severity of the ischemia. The most common early signs of ischemic colitis ... Ischemic colitis (also spelled ischaemic colitis) is a medical condition in which inflammation and injury of the large ... This vasoconstriction can result in non-occlusive ischemic colitis. A range of pathologic findings are seen in ischemic colitis ... About 20% of patients with acute ischemic colitis may develop a long-term complication known as chronic ischemic colitis. ...

*Colitis-X

Colitis X, equine colitis X or peracute toxemic colitis is a catchall term for various fatal forms of acute or peracute colitis ... Colitis-X is a term used for colitis cases in which no definitive diagnosis can be made and the horse dies. Clinical signs ... Horses under stress appear to be more susceptible to developing colitis X, and like the condition pseudomembranous colitis in ... ISBN 0-911647-30-9. Srivastava, K. "Colitis X (Peracute Toxemic Colitis)". Biomedical Research and Graduate Studies Resources, ...

*Chemical colitis

... may trigger a flare of ulcerative colitis or Crohn's colitis. Symptoms of colitis are assessed using the ... Chemical colitis can resemble ulcerative colitis, infectious colitis and pseudomembranous colitis endoscopically. Prior to 1950 ... Chemical colitis is a type of colitis, an inflammation of the large intestine or colon, caused by the introduction of harsh ... This practice will often result in chemical colitis. Soap enemas may also cause chemical colitis. Harsh chemicals, such as ...

*Cord colitis syndrome

... and others have not detected Bradyrhizobium in cord colitis samples. Gupta, NK; Masia, R (July 2013). "Cord colitis syndrome: a ... Cord colitis syndrome is a diarrheal illness in recipients of umbilical cord blood transplant. It causes a granulomatous ... The presence of enterica in the colon-biopsy samples has been suggested to help in identification of patients with cord colitis ... Gorkiewicz, G; Trajanoski, S; Högenauer, C (Nov 7, 2013). "Bradyrhizobium enterica in Cord Colitis Syndrome". The New England ...

*Crohn's & Colitis Foundation

Colitis Foundation". www.ccfa.org. "About Us - Crohn's & Colitis Foundation Information - Crohn's & Colitis Foundation". www. ... "Team Challenge - Crohn's & Colitis Foundation". www.ccteamchallenge.org. "Crohn's & Colitis Foundation". cctakesteps.org. "Team ... "About Us , Crohn's & Colitis Foundation Information , Crohn's & Colitis Foundation". www.crohnscolitisfoundation.org. Retrieved ... Crohn's and Colitis Canada Digestion Digestive Disorders Foundation National Society for Colitis and Crohn's Disease "Crohn's ...

*Management of ulcerative colitis

Ulcerative colitis is a form of colitis, a disease of the intestine, specifically the large intestine or colon, that includes ... Ulcerative colitis is a disease that affects many parts of the body outside the intestinal tract. In rare cases the extra- ... Ulcerative Colitis Practice Guidelines in Adults, Am. Coll. Gastroenterology, 2004. PDF Jowett, S L; Seal, C J; Pearce, M S; ... Ulcerative colitis is, however, a systemic disease that affects many parts of the body outside the intestine. Standard ...

*Crohn's and Colitis Canada

... , formerly known as Crohn's and Colitis Foundation of Canada, was started in 1974 by a group of ... Crohn's & Colitis Foundation of America Digestion Digestive Disorders Foundation National Society for Colitis and Crohn's ... Crohn's and Colitis Canada hosts many fundraising events throughout the year, including the Gutsy Walk held in June in over 60 ... Crohn's and Colitis Canada is a Canadian national volunteer-based charity dedicated to finding cures for Crohn's disease and ...

*Colet

... is a surname. Notable people with the surname include: Charles-Théodore Colet (1806-1883), French Roman Catholic ... English churchman and educational pioneer Louise Colet (1810-1876), French poet Colet Special Vehicle Design, a Newark, ... Archbishop Colet Abedi (21st century), Iranian-American writer and producer John Colet (1467-1519), ... California based aircraft rescue firefighting (ARFF) vehicle manufacturer founded by Ralph Colet. ...

*Cola

Corsica Cola is a regional cola distributed by the Corsican brewery Pietra. Cuba Cola is the native cola of Sweden. Evoca Cola ... Drink portal Cola chicken Cola wars Open source colas - soft drinks whose recipe is open sourced Champagne cola, a similar ... to compete with Coca-Cola and Kola.Real LA Ice Cola is an Australian cola owned by P&N Beverages, similar to Coca-Cola and ... the native Jolly Cola was more popular than Coca-Cola and Pepsi Cola during the 1960s and 1970s.[citation needed] Karma Cola, ...

*Colere

... is a comune (municipality) in the Province of Bergamo in the Italian region of Lombardy, located about 90 kilometres (56 ... As of 31 December 2004, it had a population of 1,147 and an area of 18.8 square kilometres (7.3 sq mi). Colere borders the ... Media related to Colere at Wikimedia Commons. ...

*Cole

Nova Scotia Cole Harbour Cole Harbour (Guysborough), Nova Scotia Cole, Somerset Cole, Pomeranian Voivodeship Cole, County ... Cole may refer to: A brassica, especially cabbage, kale, or rape (rapeseed). Cole Motor Car Company, a pioneer American ... USS Cole (DD-155), a United States Navy Wickes-class destroyer USS Cole (DDG-67), a United States Navy Arleigh Burke-class " ... California Cole Ranch AVA, California wine region in Mendocino County Cole County, South Dakota, the original name of Union ...

*Colares

... may refer to: Colares, Pará, a municipality in the State of Pará, Brazil Colares (Sintra), a civil parish in the ...

*Colas

... may refer to: People Claudius Colas (1884-1914), French Esperantist Emily Colas, American author Fabrice Colas (born 1964 ... English MP Paul Colas (1880-1972), French sports shooter Business and organisations Colas Group, a multi-national civil ... engineering company based in France Colas Rail, its rail freight subsidiary Cola. ...

*Coles

... may refer to: Coles Supermarkets, a supermarket chain in Australia Coles Group, (formerly Coles-Myer) former owner of ... Coles (bookstore), a bookstore chain in Canada Coles, Illinois, Coles County, Illinois, United States Coles, Mississippi, Amite ... Illinois Coles 4038, ribbon microphone produced by Coles Electroacoustics Coles (surname) Coles (given name). ... Spain Coles, South Australia, Australia Coles Bay, Tasmania, Australia Electoral district of Coles in South Australia, renamed ...

*Journal of Crohn's and Colitis

It is the official journal of the European Crohn's and Colitis Organisation. The editor-in-chief is Laurence J. Egan (NUI ... The Journal of Crohn's and Colitis is a monthly peer-reviewed medical journal covering inflammatory bowel diseases. It was ... "JCC - Journal of Crohn's and Colitis". ECCO. Retrieved 31 August 2015. "Elsevier announces new journal on inflammatory bowel ... "Journal of Crohn's and Colitis". 2014 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2015. Official ...

*Cola nitida

"Cola nitida (kola nut)". Kew Royal Botanic Gardens. Retrieved 2015-01-22. "Cola". Encyclopædia Britannica. Retrieved 2015-01-22 ... Cola nitida is an evergreen tree growing to a height of 12 to 20 metres (39 to 66 ft). The trunk is up to 1.5 m (4 ft 11.1 in) ... Cola nitida is native to Sierra Leone, Liberia, Ivory Coast, Ghana and Nigeria. It is a lowland tree but can be found up to ... Cola nitida is a species of plant belonging to the family Malvaceae. It is a tree native to the rainforests of tropical West ...

*Cole, Denver

Cole has an active neighborhood association and membership with representation on all major City projects in Cole and the ... Cole Neighborhood summary. Cole Neighborhood Association Coordinates: 39°46′01″N 104°57′57″W / 39.76696°N 104.96596°W / ... Cole is a neighborhood of Denver, Colorado. It is in the area commonly known as East Denver, or the "East Side." According to ... The Cole Neighborhood has two City Parks; Russell Square Park is in the northeast part of the neighborhood and St. Charles Park ...

*Cola gigas

... is a species of flowering plant in the Malvaceae family. It is found only in Nigeria. It is threatened by habitat ... Cola gigas. 2006 IUCN Red List of Threatened Species. Downloaded on 19 July 2007.. ...
The development of colitis is temporally and spatially regulated by a variety of immune cells in concert with colonic epithelial cells.2-4 ,8-12 However, the key cellular signals that trigger exacerbation of colitis remained unclear until the recent finding that the ATP-P2X7 signalling axis in mast cells is pivotal to intestinal inflammation in experimental colitis.8 Based on this knowledge, we demonstrate in the present study that the ceramide-LMIR3 interaction suppresses experimental colitis by inhibiting ATP-mediated mast cell activation.. Comparative analysis of DSS-induced colitis between WT and LMIR3−/− mice demonstrated that LMIR3−/− mice were more prone to colonic inflammation than WT mice under the same experimental conditions including genetic background and the dose of DSS administration: low-dose (1.5%) DSS treatment caused only mild colitis in WT C57BL/6 mice, but induced severe colitis in LMIR3−/− mice; high-dose (2.5%) DSS treatment induced lethal colitis only in most ...
Poly(ADP-ribose) polymerases (PARP) comprise a family of enzymes which catalyse poly(ADP-ribosyl)ation of DNA-binding proteins. Multiple researches indicate the importance of PARP in promoting cell recruitment and thereby inducing organ injury in various forms of inflammation, such as colitis. We have evaluated the effects of two PARP inhibitors, nicotinamide and 1,5-dihydroxyisoquinoline, in acute colitis induced by trinitrobenzensulfonic acid (TNBS) in rats. Nicotinamide (20-40 mg/kg) and 1,5-dihydroxyisoquinoline (4-8 mg/kg) were administered 48, 24 and 1 h prior to the induction of colitis as well as 24 h later. 48 h after colitis induction the lesions were blindly scored and quantified as ulcer index. Histological study and colonic inflammation were assessed by gross appearance and myeloperoxidase (MPO) activity. Prostaglandin E2 (PGE2) synthesis and, cyclooxygenase-1 and cyclooxygenase-2 expressions by Western blotting and immunohistochemistry were also performed. Inflammation following TNBS
MARQUES JR, Oswaldo et al. Cytomegaloviral colitis in HIV positive patients: endoscopic findings. Arq. Gastroenterol. [online]. 2007, vol.44, n.4, pp.315-319. ISSN 0004-2803. http://dx.doi.org/10.1590/S0004-28032007000400007.. BACKGROUND: Diarrhea in seropositive human immunodeficiency virus patients is one of the most important and disabling symptoms, and often decreases their quality of life. Cytomegalovirus colitis is among the principal causes of this symptom and colonoscopy is the gold standard examination to diagnose it. AIM: To define the main endoscopic findings in seropositive human immunodeficiency virus patients with cytomegalovirus colitis. METHODS: Two hundred and forty-three colonoscopies were performed in 200 seropositive human immunodeficiency virus patients with diarrhea associated or not to abdominal pain or gastrointestinal bleeding, over 10-year period, whom 51 patients were diagnosed with cytomegalovirus colitis. Full length colonoscopy with ileum intubation was always tried ...
This article focuses on discussing specific histologic features in biopsies of the inflammatory bowel diseases (IBDs), including ulcerative colitis, Crohn colitis, and colitis of indeterminate type. It also offers suggestions as to how to separate the IBDs from other chronic colitides, such as lymphocytic colitis, collagenous colitis, diverticular disease -associated colitis, diversion colit...
Acute colitis Acute colitis is an acute inflammatory response of the mucous membrane of the colon in response to infectious, toxic, pharmacological or endogenous factors.
Doctor answers on Symptoms, Diagnosis, Treatment, and More: Dr. Fisher on handling distal colitis condition: ileo-rectal anastamosis. You can always go back to colostomy. Consult with your surgeon regarding specific advice in your case. for topic: Handling Distal Colitis Condition
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The usual treatment of colitis with suppressive drugs is based on the assumption that colitis is due to germ infection, which it is not. The suppressive drugs drive back into the system the toxic matter in the colon which nature is endeavouring to eliminate in the form of mucus. They suppress the symptoms temporarily, without removing the cause. In such cases, the symptoms of colitis recur and colitis becomes chronic. Plain warm water or warm water with a little olive oil used as a wash-out is the only method of softening and removing the accumulations of hardened matter sticking to the walls of the colon. Diet plays an important part in the treatment of colitis. It is advisable to observe a juice fast for five days or so in most cases of ulcerative colitis. The juices may be diluted with a little boiled water. Papaya juice, raw cabbage and carrot juices will be especially beneficial. Citrus juices should be avoided. The bowel should be cleansed daily with a warm water enema. After the juice ...
colitis cure - MedHelps colitis cure Center for Information, Symptoms, Resources, Treatments and Tools for colitis cure. Find colitis cure information, treatments for colitis cure and colitis cure symptoms.
Colitis in the adult horse is a challenge to definitively diagnose and often costly to successfully treat. It is also a difficult disease to explain to horse owners.. Colitis is inflammation of the large colon, the lower part of the intestine where most of the critical fermentation, digestion, and absorption of feed takes place. The colon is a piece of intestine that is approximately 9 feet long, 10 inches in diameter and weighing 150 lbs when it contains feed. When this giant organ is unhealthy, so is the horse. The key to understanding colitis is understanding the delicate bacterial balance that exists in the colon. Anything that disrupts this balance, including infectious agents or antibiotics, can cause life threatening disease. Colitis is usually caused by Salmonella, Clostridial infection, and Potomac Horse Fever (protozoal infection).. My approach to acute colitis is to treat as it aggressively as possible early in the course of disease. This provides the best chance for survival and ...
Evidence strongly supported a link between inflammation and cancer. Patients with colitis have high risk for development of colon cancer. Nuclear factor-kappa B (NF-B), partially induced by lipopolysaccharide (LPS) binding to Toll-like receptor (TLR) 4, is a vital molecule in supervising the transformation of colitis to colon cancer. It could be a good strategy to prevent colitis carcinogenesis for targeting LPS/TLR4/NF-B pathway. In the present study, we obtained an oligogalactan composed of five galacturonic acids from apple pectin and evaluated its protective efficacy on intestinal toxicities and carcinogenesis in a mouse model of colitis-associated colon cancer induced by 1,2-dimethylhydrazine and dextran sodium sulfate (DSS). The apple oligogalactan (AOG) was highly effective against intestinal toxicities and carcinogenesis and decreased the elevated levels of TLR4 and tumor necrosis factor- (TNF-) induced by inflammation in vivo in this model system. In vitro studies, AOG alone only ...
Ulcerative colitis is a dynamic, chronic inflammatory condition associated with an increased colon cancer risk. Inflammatory cell apoptosis is a key mechanism regulating ulcerative colitis. American ginseng (AG) is a putative antioxidant that can suppress hyperactive immune cells. We have recently shown that AG can prevent and treat mouse colitis. Because p53 levels are elevated in inflammatory cells in both mouse and human colitis, we tested the hypothesis that AG protects from colitis by driving inflammatory cell apoptosis through a p53 mechanism. We used isogenic p53+/+ and p53−/− inflammatory cell lines as well as primary CD4+/CD25− effector T cells from p53+/+ and p53−/− mice to show that AG drives apoptosis in a p53-dependent manner. Moreover, we used a dextran sulfate sodium (DSS) model of colitis in C57BL/6 p53+/+ and p53−/− mice to test whether the protective effect of AG against colitis is p53 dependent. Data indicate that AG induces apoptosis in p53+/+ but not in ...
Preclinical evaluation of potential drug candidates for human inflammatory bowel disease is performed in murine models of colitis. The most widely used model is dextran-sodium sulfate(DSS)-induced colitis. Non-invasive imaging of murine experimental colitis by Positron emission tomography (PET) combined with radiotracers is feasible and offers the opportunity of serial follow-up investigations. This technique significantly reduces the number of test animals. More... ...
The role of infliximab in the treatment of patients with ulcerative colitis (UC) in Asia is still unclear. The aim of this study was to evaluate the clinical outcomes of infliximab therapy in Korean U
Stress or chronic Colitis in Dogs. What to do when canine colitis is brought on by stress? And how to recognize Stress or chronic Colitis in Dogs? Go here!
Looking for colitis? Find out information about colitis. inflammation of the colon, or large intestine intestine, muscular hoselike portion of the gastrointestinal tract extending from the lower end of the stomach... Explanation of colitis
Colitis is associated with the development of colorectal cancer (CRC) by largely undefined mechanisms that are critical for understanding the link between inflammation and cancer. Intestinal stem cells (ISCs) marked by LGR5 expression are of importance in both the inflammatory response to colitis and progression to colitis-associated colon cancer (CACC). Here, we report in human MUC1-transgenic mouse models of CACC that targeting the MUC1-C oncogenic protein, which is upregulated in inflammation, suppresses the (i) Lgr5+ ISC population, (ii) induction of Myc and core pluripotency stem cell factors, and (iii) severity and progression of colitis to dysplasia and cancer. By extension to human colon cancer cells, we demonstrate that MUC1-C drives MYC, forms a complex with MYC on the LGR5 promoter and activates LGR5 expression. We also show in CRC cells that MUC1-C induces the cancer stem cell (CSC) markers (BMI1, ALDH1, FOXA1, LIN28B) and the OCT4, SOX2 and NANOG pluripotency factors. Consistent ...
Intestinal permeability and contractility in murine colitis. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
In this study, we have analyzed the role of IL-10 signaling in CD4 T cells by generating dominant-negative IL-10Rα TG mice. Our results indicated that direct IL-10 signals control colitis development, in particular when caused by the Treg cell-depleted CD45RBlo memory/effector CD4 T cell population. This has also spotlighted characteristic differences in the mechanism of colitis development mediated by CD45RBhi cells or Treg cell-depleted CD45RBlo CD4+ T cells.. It was previously reported by others that activation could reduce the expression of IL-10R1 (IL-10Rα) mRNA in human T cell clones (Liu et al., 1994). We found that although expression of mouse IL-10Rα is reduced upon activation, it recovered after 24-48 h both at the level of mRNA (not depicted) and cell surface protein expression (Fig. S1). In addition, the surface expression of IL-10Rα is detectable at any time of activation by flow cytometry. The IL-10Rα on the surface of T cells is functional after IL-10 stimulation as Stat3 ...
In this study, we have analyzed the role of IL-10 signaling in CD4 T cells by generating dominant-negative IL-10Rα TG mice. Our results indicated that direct IL-10 signals control colitis development, in particular when caused by the Treg cell-depleted CD45RBlo memory/effector CD4 T cell population. This has also spotlighted characteristic differences in the mechanism of colitis development mediated by CD45RBhi cells or Treg cell-depleted CD45RBlo CD4+ T cells.. It was previously reported by others that activation could reduce the expression of IL-10R1 (IL-10Rα) mRNA in human T cell clones (Liu et al., 1994). We found that although expression of mouse IL-10Rα is reduced upon activation, it recovered after 24-48 h both at the level of mRNA (not depicted) and cell surface protein expression (Fig. S1). In addition, the surface expression of IL-10Rα is detectable at any time of activation by flow cytometry. The IL-10Rα on the surface of T cells is functional after IL-10 stimulation as Stat3 ...
The mechanisms of wound healing in the gut are poorly understood but are mediated by cytokines in other tissues. In this study we wanted to determine which cytokines were expressed after nonspecific colonie injury, the kinetics of that expression, and how cytokine expression correlated with tissue histology. At 0,4, 8,12,24,48, and 72 h after intrarectal administration of 3% acetic acid to C3H/HeJ mice, their colons were removed for histology, organ culture, and RNA extraction. Cytokine mRNA expression for various cytokines was assessed by reverse transcriptase-polymerase chain reaction with primers specific for each cytokine. Cytokine production in organ cultures was measured with bioassays. Shortly after colonie injury and during colonie regeneration, proinflammatory cytokines such as interleukin-lβ (IL-lβ), IL-6, tumor necrosis factor-α (TNF-α), macrophage inflammatory protein (MIP), and transforming growth factor-β (TGF-β) were expressed. In contrast, expression of T cell-derived ...
BACKGROUND & AIMS: Innate lymphoid cells (ILCs) are a heterogeneous group of mucosal inflammatory cells that participate in chronic intestinal inflammation. We investigated the role of interleukin 6 (IL6) in inducing activation of ILCs in mice and in human beings with chronic intestinal inflammation. METHODS: ILCs were isolated from colons of Tbx21(-/-) × Rag2(-/-) mice (TRUC), which develop colitis; patients with inflammatory bowel disease (IBD); and patients without colon inflammation (controls). ILCs were characterized by flow cytometry; cytokine production was measured by enzyme-linked immunosorbent assay and cytokine bead arrays. Mice were given intraperitoneal injections of depleting (CD4, CD90), neutralizing (IL6), or control antibodies. Isolated colon tissues were analyzed by histology, explant organ culture, and cell culture. Bacterial DNA was extracted from mouse fecal samples to assess the intestinal microbiota. RESULTS: IL17A- and IL22-producing, natural cytotoxicity ...
The results demonstrate that the PAR2 antagonist GB88 has significant disease-modifying benefits in experimental colitis, supporting a pivotal role for PAR2 in the pathogenesis of IBD. Until now, there has been no potent or orally bioavailable PAR2 antagonist available to investigate PAR2 antagonism in vivo. We have found here that a PAR2 agonist induces acute symptoms of colitis-like inflammation (edema, mastocytosis, mucin depletion, and mucosal erosion) in rats and demonstrated that the PAR2 antagonist GB88 ameliorates colonic inflammation in this model. Moreover, GB88 was also efficacious in a more general chronic (TNBS-induced) model of experimental colitis in rats, being more effective than the clinically used sulfasalazine (at 10% of the dose). The data support the development of PAR2 antagonists for treating IBDs.. In rats receiving intracolonic PAR2 agonist, we have also made the novel finding of an inverse relationship between PAR2 expression in the cytosol of mucosal goblet cells and ...
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ANSWER: Dogs with colitis often have fresh, red blood and/or mucus in their stools. In some cases, your dog may seem constipated and strain without producing any feces. With acute colitis, your dog might show no other signs of being sick except diarrhea or straining to defecate.
Request sample of market research report on Colitis Pipeline Review H1 2016. Explore detailed TOC, tables and figures of Colitis Pipeline Review H1 2016.
In humans, colonoscopy is the gold standard for the diagnosis of inflammatory changes of the colon wall. Aim of this study was the identification of less i
Do You Have Colitis? Join friendly people sharing true stories in the I Have Colitis group. Find forums, advice and chat with groups who share this life experience.
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Colitis is inflammation of the colon. In severe cases the colon can become ulcerated. Symptoms include the passage of offensive watery stools with mucus and pus, abdominal pain or tenderness, and intermittent or irregular fever. Colitis is invariably caused by hidden … Continue reading →. ...
Not all treatment methods can cure a dog entirely of colitis. However, most cases can be managed so that your dog will live a normal and healthy life. Depending on the severity of the situation and aside from any other issues, dietary changes might be all that are needed to treat your dog. You may need to switch to a food that your dog finds easier to digest. Keep trying until you find one that is both nutritional and easily digestible for your dog. If your dogs condition has been caused by bacteria or a parasite, an antibiotic will be administered to treat it. Your dog will probably also be prescribed medicine to help reduce the inflammation and pain. There are also long-term medications available, in the event that your dog will need to remain on antibiotic treatment indefinitely. The most important aspect of treatment is being proactive in recognizing any unusual signs in your dog. Because colitis will continue to recur if underlying conditions are not corrected, they need to be diagnosed, ...
Is Colitis Ischaemic a common side effect of Solupred? View Colitis Ischaemic Solupred side effect risks. Female, 80 years of age, was diagnosed with prophylaxis, bronchitis, pain and took Solupred Unk Mg, Unk.
Gronbach, Kerstin; Flade, Isabell; Holst, Otto; Lindner, Buko; Ruscheweyh, Hans Joachim; Wittmann, Alexandra; Menz, Sarah; Schwiertz, Andreas; Adam, Patrick; Stecher, Baerbel; Josenhans, Christine; Suerbaum, Sebastian; Gruber, Achim D.; Kulik, Andreas; Huson, Daniel; Autenrieth, Ingo B.; Frick, Julia-Stefanie ...
Be Unique. Shop crohns and colitis awareness hoodies created by independent artists from around the globe. We print the highest quality crohns and colitis awareness hoodies on the internet.
Eva Hainzl, Silvia Stockinger, Isabella Rauch, Susanne Heider, David Berry, Caroline Lassnig, Clarissa Schwab, Felix Rosebrock, Gabriel Milinovich, Michaela Schlederer, Michael Wagner, Christa Schleper, Alexander Loy, Tim Urich, Lukas Kenner, Xiaonan Han, Thomas Decker, Birgit Strobl, Mathias ...
Ji H, Rabbi MF, Labis B, Pavlov VA, Tracey KJ, and Ghia JE. Mucosal Immunol. 2014 Mar;7(2):335-47. doi: 10.1038/mi.2013.52. Epub 2013 Jul 24 ...
Recent research from the laboratory of Michael Karin, PhD, at the University of California, San Diego School of Medicine - the first researcher to demonstrate a molecular link between inflammation and cancer - has identified ...
The many diseases that cause colitis, or inflammation of the bowel, differ in severity, additional symptoms and treatments, according to Healthline. These diseases include Crohns disease, ulcerative...
Takeda Pharmaceutical Co. Ltd.s Experimental Crohns, Colitis Drug Effective - read this article along with other careers information, tips and advice on BioSpace
The mouse study finds that Ganeden Biotechs probiotic, GanedenBC30® minimizes severity and duration of C. diff-induced colitis, or inflammation of the colon.
Some simple dietary changes can be made to help limit the severity of colitis symptoms, such as cutting out or limiting the amount of fried foods and eating smaller portions more often, as opposed to...
This formula eliminates the energetic field within which Colitis occurs and returns the body to normal functioning.Illness and physical problems arise
Compare risks and benefits of common medications used for Colitis. Find the most popular drugs, view ratings, user reviews, and more...
ERCs modulate the levels of immune cells in the spleen of colitis mice. The levels of immune cells were analyzed by flow cytometry in different groups. A) The l
AP-1 and NF-κB inhibitors, namely, DTCM-G and DHMEQ, were investigated in male Wistar rats with severe colitis, induced by TNBS. The animals were randomized into 3 groups. The control group received 0.5 mL of 0.5% of the ...
when i move a certain way my lower right side hurts. it doesnt hurt when im not moving and when im walking straight. when i twist my body it really hurts what can it be please help
An inflamed colon, or colitis, may arise from a variety of causes, including infections, antibiotics or reduced blood flow to the colon. But as all causes...
The therapeutic potential of helminth-derived products in an experimental animal model of colitis: study of the underlying immunological ...
Find out what Kim is doing to put an end to the 6 years that have taken place since her diagnosis. Shes finally got a new plan to attack the colitis symptoms, and shes looking for 2014 to be a breakthrough year.
Warning: Poop talk ahead Okay, so Ive been miserable for several weeks, and there has been some discussion regarding the potential need to increase my Humira. There was also concern that I was suffering from C.diff colitis, only now Im in the same place I was this same time last year, painfully constipated. I actually…
The complement system is a potent effector of innate immunity. To elucidate the pathophysiological role of the complement system in inflammatory bowel disease (IBD), we evaluated the development of dextran sulfate sodium (DSS)-induced colitis in genetically complement C5-deficient mice. We used DBA2/J mice, which are genetically deficient in complement C5. DBA1/J mice have a normal complement system, and were used as controls. Experimental colitis was induced by the oral administration of 3.5% (w/v) DSS in their drinking water for 10 days. On day 10, all mice were sacrificed and their colons were collected. The development of colitis was assessed by the histological score, disease activity index, myeloperoxidase (MPO) activity, and macroscopic changes of the colon. Body weight loss was more apparent in the DBA2/J mice than in control DBA1/J mice. The colon length was shorter in the DBA2/J mice than in DBA1/J mice. The disease activity index, histological colitis score, and MPO activity were all ...
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TY - JOUR. T1 - Protective effect of amphipterygium adstringens extract on dextran sulphate sodium-induced ulcerative colitis in mice. AU - Rodriguez-Canales, Mario. AU - Jimenez-Rivas, Ruben. AU - Canales-Martinez, Maria Margarita. AU - Garcia-Lopez, Ana Judith. AU - Rivera-Yañez, Nelly. AU - Nieto-Yañez, Oscar. AU - Ledesma-Soto, Yadira. AU - Sanchez-Torres, Luvia Enid. AU - Rodriguez-Sosa, Miriam. AU - Terrazas, Luis Ignacio. AU - Rodriguez-Monroy, Marco Aurelio. PY - 2016/1/1. Y1 - 2016/1/1. N2 - © 2016 Mario Rodriguez-Canales et al. Amphipterygium adstringens is an endemic species in Mexico commonly known as "cuachalalate." Healers to treat gastritis, gastric ulcers, and gastrointestinal cancer have traditionally used the bark. We investigated the effects of alcoholic extract of A. adstringens (AaEE) in DSS-induced colitis in mice. The protective effect of AaEE was determined at 200 mg/kg by oral gavage for 10 days. We determine the effect of AaEE on clinical features (disease activity ...
Adrenomedullin (AM) is a biologically active peptide which has been tested as a new therapy for inflammatory bowel disease (IBD) in animal models and in patients with severe ulcerative colitis. We used an inducible knockout (KO) mouse model for AM to evaluate the effects of endogenous levels of this peptide on the development and degree of pathogenesis of IBD. Acute colitis was induced in mice of both sexes by rectal instillation of 3 mg 2,4,6-trinitrobenzenesulfonic acid (TNBS) in 100 µL of 50% ethanol. Control mice received the same volume of saline in 50% ethanol. During the following 5 days, the weight and the disease severity index of all animals were recorded. After sacrifice, the inflammatory response was macroscopically assessed by analyzing the weight of the colon; by histomorphometrical analysis on histological sections; and by qRT-PCR determination of different inflammatory, adhesion, and regeneration molecules. TNBS administration caused a significantly more severe colitis in KO mice, and
Although Western diet and dysbiosis are the most prominent environmental factors associated with inflammatory bowel diseases (IBDs), the corresponding host factors and cellular mechanisms remain poorly defined. Here we report that the TSC1/mTOR pathway in the gut epithelium represents a metabolic and innate immune checkpoint for intestinal dysfunction and inflammation. mTOR hyperactivation triggered by Western diet or Tsc1 ablation led to epithelium necroptosis, barrier disruption, and predisposition to dextran sulfate sodium-induced colitis and inflammation-associated colon cancer. Mechanistically, our results uncovered a critical role for TSC1/mTOR in restraining the expression and activation of RIPK3 in the gut epithelium through TRIM11-mediated ubiquitination and autophagy-dependent degradation. Notably, microbiota depletion by antibiotics or gnotobiotics attenuated RIPK3 expression and activation, thereby alleviating epithelial necroptosis and colitis driven by mTOR hyperactivation. mTOR ...
Ischemic colitis occurs when blood flow to part of the large intestine (colon) is reduced, usually due to narrowed or blocked blood vessels (arteries). The diminished blood flow doesnt provide enough oxygen for the cells in your digestive system.. Ischemic colitis can cause pain and may damage your colon. Any part of the colon can be affected, but ischemic colitis usually causes pain on the left side of the belly area (abdomen).. The condition can be misdiagnosed because it can easily be confused with other digestive problems. Ischemic colitis may heal on its own. But you may need medication to treat ischemic colitis or prevent infection, or you may need surgery if your colon has been damaged.. Signs and symptoms of ischemic colitis can include:. ...
Ulcerative colitis (UC) and Crohns disease (CD) constitute the two major inflammatory bowel diseases in man. Both are serious chronic illnesses of the intestine with severe debilitating effects. The etiology of the diseases is unknown, but involvement of both adaptive and innate immune reactions seems to be major factors in the pathogenesis. In this thesis the roles of key molecules of the adaptive immunity, i.e. interleukin-2 (IL-2), and innate immunity, i.e. β-defensins, were studied both in human inflammation of the large intestine and in mouse colitis models.. β-defensins are small endogenous peptides with antimicrobial activity. Previous studies showed that expression of human β-defensin-2 (hBD-2), hBD-3, and hBD-4 is induced in colonic epithelial cells of UC patients. Here we demonstrate that cells expressing these three β-defensins are present also in the colonic lamina propria of UC patients and less frequently in CD patients, and controls. These cells were identified as mature ...
Calcitriol Inhibits the Th1 and Promotes the Th2 Profile in Mice with TNBS Colitis. Th1 lymphocyte differentiation is known to be based on a sequence of cell-intrinsic and exogenous, DC-derived factors, including augmentation of the transcription factor T-bet following activation by DC-derived IL-12. The observed reduction of the Th1 mediators, especially after treatment with the combination of dexamethasone and calcitriol, was further confirmed by immunoblot analysis of the T-bet. The combined administration of calcitriol and dexamethasone led to a significant reduction of T-bet protein expression compared with dexamethasone monotherapy (P , 0.001 versus dexamethasone, Fig. 3, A and B). As a next step to assess a possible role of calcitriol and dexamethasone in promoting the Th2 subset, we analyzed IL-4 production as well as the relevant Th2 lineage commitment factor GATA3. Calcitriol significantly up-regulated IL-4, whereas dexamethasone alone did not cause any significant change in IL-4 ...
The imbalance of gut microbiota is known to be associated with inflammatory bowel disease, but it remains unknown whether dysbiosis is a cause or consequence of chronic gut inflammation. In order to investigate the effects of gut inflammation on microbiota and metabolome, the sequential changes in gut microbiota and metabolites from the onset of colitis to the recovery in dextran sulfate sodium-induced colitic mice were characterized by using meta 16S rRNA sequencing and proton nuclear magnetic resonance (1H-NMR) analysis. Mice in the colitis progression phase showed the transient expansions of two bacterial families including Bacteroidaceae and Enterobacteriaceae and the depletion of major gut commensal bacteria belonging to the uncultured Bacteroidales family S24-7, Rikenellaceae, Lachnospiraceae, and Ruminococcaceae. After the initiation of the recovery, commensal Lactobacillus members promptly predominated in gut while other normally abundant bacteria excluding the Erysipelotrichaceae remained
Recent studies show that colonic vitamin D receptor (VDR) signaling protects the mucosal epithelial barrier and suppresses colonic inflammation, but the underlying molecular mechanism remains to be fully understood. To investigate the implication of colonic VDR down-regulation seen in patients with inflammatory bowel disease, we assessed the effect of gut epithelial VDR deletion on colonic inflammatory responses in an experimental colitis model. In 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis model, mice carrying VDR deletion in gut epithelial cells (VDRf/f;Villin-Cre or VDRΔIEC) or in colonic epithelial cells (VDRf/f;CDX2-Cre or VDRΔCEC) developed more severe clinical colitis than VDRf/f control mice, characterized by more robust TH1 and TH17 responses, with greater increases in mucosal IFN-γ+, IL-17+ and IFN-γ+IL-17+ T cells ...
In this report we have added to our understanding of the role of ILK in intestinal pathophysiology, specifically in the setting of bacterial infection. Similar to the findings reported for DSS-induced colitis we show that there is a reduced inflammatory response, associated with a reduction in CCL2 expression, an important immune cell chemoattractant. Furthermore, our findings indicate that the pattern but not the magnitude of epithelial C. rodentium binding is altered in the ILK-ko mice, with preserved apical binding but reduced lateral epithelial cell binding/migration, in between adjacent crypts. Although the reduced expression of fibronectin may account for this finding, we cannot exclude alterations in other extracellular matrix components, or alterations in the levels of other cell surface integrins as being involved in this response. An additional role for ILK is indicated by the reduced crypt hyperplasia observed associated with decreased cyclin D1 on immunohistochemistry, in ILK-ko ...
The aim of the present study was to examine the role of endogenous peroxisome proliferator-activated receptor-α (PPAR-α) ligand on the permeability and structure of small intestine tight junctions (TJs) in an animal model of experimental colitis, induced by dinitrobenzene sulfuric acid (DNBS). Four days after colitis induction with DNBS, the ileal TJs were studied by means of transmission electron microscopy using lanthanum nitrate and immunohistochemistry of occludin, zonula occludens 1, and claudin 2. Administration of DNBS to wild-type mice induced colon injury associated with a significant increase of plasma and colon tumor necrosis factor-α levels and with a significant increase of ileal permeability. Distal colitis in mice induced an increase of TJ permeability throughout the entire small intestine, and the extent of alterations correlates with colonic damage. Small intestinal permeability was associated with the presence of apoptosis (evaluated by FAS ligand expression and terminal ...
Ischaemic colitis. Endoscopic view of the interior of a patients colon (large intestine) affected by ischaemic colitis. Ischaemic colitis is the inflammation of the colon due to reduced blood supply. Ischaemia is an uncommon cause of colitis and is caused by narrowing of the arteries supplying the intestines by atherosclerosis (the build up of plaque on the inner lining of an artery). Bloody diarrhoea and abdominal pain may be a symptom of chronic conditions. - Stock Image C025/0068
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In our most recent study, we demonstrated that the consumption of supplemental psyllium fibre increased the expression of intestinal cytoprotective Hsp25 expression and increased intestinal tissue resistance to oxidative stress in mice( 9 ). In the present study, DNA microarray analysis was used to examine the colonic expression of Hsp25 and other cytoprotective proteins in mice that were fed psyllium fibre to determine the protective effect on DSS-induced colitis. The supplemental psyllium fibre increased ECM-associated proteins, such as collagens and fibronectins, and Hsp25 in the colons of normal mice. In colitic mice, the supplemental psyllium fibre effectively reduced colonic inflammation and intestinal barrier impairment. In the final experiment, examination of intestinal Caco-2 cells provided direct evidence of intestinal barrier regulation by collagen and fibronectin, which were induced by psyllium fibre consumption. Therefore, increased expression of Hsp25 and ECM-associated proteins ...
Background. Anti-inflammatory and immunomodulatory activities have been reported for maprotiline, a strong norepinephrine reuptake inhibitor. In addition, some other antidepressant drugs have shown beneficial effects in experimental colitis. Methods. All the animals were divided into normal and depressed groups. In normal rats colitis was induced by instillation of 2 mL of 4% acetic acid and after 2 hours, maprotiline (10, 20, and 40 mg/kg, i.p.) was administered. In reserpinised depressed rats, depression was induced by injection of reserpine (6 mg/kg, i.p.), 1 h prior to colitis induction, and then treated with maprotiline (10, 20, and 40 mg/kg). Treatment continued daily for four days. Dexamethasone (1 mg/kg, i.p.) was given as a reference drug. On day five following colitis induction, animals were euthanized and distal colons were assessed macroscopically, histologically, and biochemically (assessment of myeloperoxidase activity). Results. Maprotiline significantly improved macroscopic and ...
Ulcerative colitis is an inflammatory bowel disease that is a chronic autoimmune disorder of the colon. Despite the best medical management, ulcerative colitis patients often experience episodic flare-ups with symptoms that include abdominal pain, diarrhea, and rectal bleeding. Flare-ups are sometimes triggered by stress, and there is a great deal of interest in stress-reduction interventions that might improve quality of life and reduce flare-ups, and defining those ulcerative colitis subpopulations that might benefit most from such techniques.. Jedel et al. [Digestion] studied MBSRs effectiveness in preventing ulcerative colitis flare-ups in a randomized, double-blind study. Fifty-five moderately severe ulcerative colitis patients in remission were assigned to either MBSR or a placebo (lectures and videos on mind/body medicine). Moderate severity of disease status was defined by a Mayo Ulcerative Colitis Disease Activity Index of 6-12. Measures taken at baseline, post-treatment, and 6 and ...
TY - JOUR. T1 - Regulatory role of B-1 B cells in chronic colitis. AU - Shimomura, Yasuyo. AU - Mizoguchi, Emiko. AU - Sugimoto, Ken. AU - Kibe, Ryoko. AU - Benno, Yoshimi. AU - Mizoguchi, Atsushi. AU - Bhan, Atul K.. PY - 2008/6/1. Y1 - 2008/6/1. N2 - According to the hygiene hypothesis, enhanced microbial exposure due to early childhood infections leads to a reduction of Th 2-mediated allergic diseases and inflammatory bowel disease. To begin to elucidate the mechanisms underlying this hypothesis, we studied development of Th2-mediated colitis of the TCRα knockout (KO) mouse in both a specific pathogen-free (SPF) facility and a conventional (CV) facility. After more than five generations in each facility, TCRα KO mice kept in the CV facility developed dramatically less colitis than mice that were kept in the SPF facility. Surprisingly, the suppression of colitis in the CV facility correlated with a significant increase in natural IgM production by B-1 B cells. In contrast, B cell-deficient ...
Background and aims: Interleukin-12 (IL-12), a p35/p40 heterodimer, plays a pivotal rote in the immune response in Crohns disease (CD). Since IL-12 p40 dimers act as IL-12 antagonists, we assayed p40 dimer proteins to modulate chronic intestinal inflammation. Methods: We generated a fusion protein consisting of the IL-12(p40) subunit fused to the constant region of IgG2b. IL-12(p40)-IgG2b was tested in a murine 2,4,6,-trinitrobenzene sulphonic acid (TNBS) colitis model and in lamina propria mononuclear cells (LPMNC) from patients with CD in vitro. Results: Dimeric IL-12(p40)-IgG2b fusion protein bound specifically to the IL-12 receptor. In concentrations ...
Background MicroRNA-21 (miR-21) is overexpressed in most inflammatory diseases, but its physiological role in gut inflammation and tissue injury is poorly understood. The goal of this work is to understand the role of miR-21 in colitis and damage progression of intestine in a genetically modified murine model. Methods Experimental colitis was induced in miR-21 KO and wild-type (WT) mice by 3.5% dextran sulphate sodium (DSS) administration for 7 days. Disease activity index(DAI), blood parameters, intestinal permeability, histopathologic injury, cytokine and chemokine production, and epithelial cells apoptosis were examined in colons of miR-21 KO and WT mice. Results miR-21 was overexpressed in intestine of inflammatory bowel diseases (IBD) and acute intestinal obstruction (AIO) patients when compared with normal intestinal tissues. Likewise, miR-21 was up-regulated in colon of IL-10 KO mice when compared with control mice. WT mice rapidly lost weight and were moribund 5 days after treatment with 3.5%
sodium sulfate is a very cheap material. The largest use is as filler in powdered home laundry detergents, consuming approx. 50% of world production. This use is waning as domestic consumers are increasingly switching to compact or liquid detergents that do not include sodium sulfate. Another formerly major use for sodium sulfate, notably in the US and Canada, is in the Kraft process for the manufacture of wood pulp. Organics present in the black liquor from this process are burnt to produce heat, needed to drive the reduction of sodium sulfate to sodium sulfide.. The glass industry provides another significant application for sodium sulfate, as second largest application in Europe. Sodium sulfate is used as a fining agent, to help remove small air bubbles from molten glass. It fluxes the glass, and prevents scum formation of the glass melt during refining. The glass industry in Europe has been consuming from 1970 to 2006 a stable 110,000 tonnes annually.. Sodium sulfate is important in the ...
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Animals. BALB/cByJ-Lpin1fld/J mice were purchased from The Jackson Laboratory and bred in the Service of Animal Research and Welfare of the University of Valladolid, as previously described (16). Most of the experiments were conducted with 12-week-old female animals.. Colitis induction. Acute experimental colitis was induced by adding 3% (w/v) DSS, 36-50 kDa (MP Biomedicals, Inc.) to drinking water. Fresh DSS solution was prepared daily. Six days after initiation of treatment, animals were just kept on regular drinking water for 2 additional days. Control groups received regular drinking water during the whole experiment. Body weight and DAI were evaluated daily as an indirect measure of colitis severity. DAI was evaluated as the combined scores of weight loss, stool consistency, and fecal blood (27). At day 3 or 8 after induction of colitis, mice were sacrificed under ketamine and xylazine (100 mg/kg and 10 mg/kg, respectively) and cervical dislocation. The abdominal cavity was exposed and ...
This study showed that evidence of minor immunodeficiency is common in infants with non-infective colitis. In agreement with previous studies we have confirmed that in this age group the commonest cause of non-infective colitis is allergic colitis.1 5 6 9 11 14 15 Ulcerative colitis, non-specific colitis, autoimmune enterocolitis, and severe combined immunodeficiency accounted for only approximately one third of the cases, occurring with the same frequency.. Serum IgG2 and IgG4 deficiency commonly coexisted with deficiencies of IgA, raised IgE or both in this group of infants with colitis.16 17 These immunoglobulins have a role in health in protecting the individual against the uncontrolled absorption of whole proteins and complex antigens from the gastrointestinal lumen. Previous work has shown that the formation of immune complexes, particularly IgA specific immune complexes, may contribute to the release of goblet cell mucus onto the intestinal surface, thus preventing the penetration of ...
Research Report on Global Dextran Sulfate Sodium Salt (CAS 9011-18-1) Market Professional Survey Report 2017. The Report includes market price, demand, trends, size, Share, Growth, Forecast, Analysis & Overview.
Looking for online definition of chemical colitis in the Medical Dictionary? chemical colitis explanation free. What is chemical colitis? Meaning of chemical colitis medical term. What does chemical colitis mean?
Dec 13, 2011. A severe lack of hydrochloric acid- most prevalent after the age of. Diagnosing insufficient stomach acid is a tricky problem because the symptoms for too. Start with one or two per day and increase your intake gradually. these products but are still experiencing rosacea, then, HCL may be the culpirt.. Verified answers to common questions about rosacea symptoms and treatment.. Allegra and Singulair are medications often prescribed to relieve symptoms associated with allergies. Both medications can be prescribed.. Aug 16, 2016. When you hear the term gut health you can be excused for assuming it is limited to stomach related conditions such as irritable bowel.. Causes and natural remedies for Colitis, including dietary changes, supplements and a comprehensive Wellness Program -Colitis, Ulcertative Colitis, Colitis Information, Colitis Ulcerative, Colitis Treatments, Colitis Remedies, Colitis Natural Treatment, Colitis Symptoms, acute Colitis, Colitis Diet, Ulcerative Colitis Diet, ...
Materials and Methods We performed DSS-induced colitis in Scd4-/- and C57BL/6 WT mice. We used weight loss, colon length and histological scoring of colonic modifications to measure the course of colitis. Scd4-/- and WT mice were orally gavaged with 5 × 108 colony-forming units (CFU) of invasive bacterium Citrobacter rhodentium (C. rhodentium). The changes of body weight and faecal excretion of C. rhodentium were monitored for 21 days followed by evaluation of histological changes after infection. The permeability of the colon was examined in vitro by infection of colon samples from Scd4-/- and C57BL/6 WT mice with C. rhodentium. The migration behaviour of endothelial human cells (T-84) and scd4-siRNA T-84 knockdown cells was analysed by scratch assay. ...
Resident and inflammatory mononuclear phagocytes (MPhs) with functional plasticity in the intestine are critically involved in the pathology of inflammatory bowel diseases (IBDs), the mechanism of which remains incompletely understood. In the present study, we found that increased expression of the E3 ligase F-box and WD repeat domain-containing 7 (FBXW) in the inflamed intestine was significantly correlated with IBD severity in both human diseases and in mouse models. Myeloid Fbxw7 deficiency protected mice from colitis induced by dextran sodium sulfate (DSS) or 2,6,4-trinitrobenzene sulfonic acid (TNBS). Fbxw7 deficiency resulted in decreased production of the chemokines CCL2 and CCL7 by colonic CX3CR1hi resident macrophages and reduced the accumulation of CX3CR1int proinflammatory MPhs in colitis-affected colon tissue. Mice that received adeno-associated virus-shFbxw7 (AAV-shFbxw7) showed significantly improved survival rates and alleviation of colitis. Mechanism screening demonstrated that ...
What Is Colitis?. Colitis is the inflammation of the colon, which is the last portion of the digestive tract. Under normal conditions, the colon stores feces while absorbing fluid and nutrients. When the colon is inflamed, these functions are affected. Additional fluid is left in the colon, resulting in diarrhea.. Colitis may be acute, occurring for only a few days, or the condition may be chronic and last for months. Any dog or cat may experience colitis.. What Are the Signs of Colitis?. Diarrhea, often with mucus and/or fresh blood, is the hallmark of colitis. Pets with colitis often defecate with greater urgency and frequency. They may strain while defecating, causing some pet owners to mistakenly believe the pet is constipated. Some pets may vomit. Despite these signs, weight loss is usually not associated with colitis.. What Causes this Condition?. Acute forms of colitis may occur during or after stressful situations, such as boarding, grooming, or thunderstorms. Colitis can also happen ...
What Is Colitis?. Colitis is the inflammation of the colon, which is the last portion of the digestive tract. Under normal conditions, the colon stores feces while absorbing fluid and nutrients. When the colon is inflamed, these functions are affected. Additional fluid is left in the colon, resulting in diarrhea.. Colitis may be acute, occurring for only a few days, or the condition may be chronic and last for months. Any dog or cat may experience colitis.. What Are the Signs of Colitis?. Diarrhea, often with mucus and/or fresh blood, is the hallmark of colitis. Pets with colitis often defecate with greater urgency and frequency. They may strain while defecating, causing some pet owners to mistakenly believe the pet is constipated. Some pets may vomit. Despite these signs, weight loss is usually not associated with colitis.. What Causes this Condition?. Acute forms of colitis may occur during or after stressful situations, such as boarding, grooming, or thunderstorms. Colitis can also happen ...
Ulcerative colitis (UC) is a chronic inflammatory condition of the mucosa affecting the rectum and extending up the colon in a continuous manner. Its etiology is unknown, but is most probably the result of the interaction of genetic and environmental factors. Approximately 30% of UC patients will need to undergo surgery at some point during their lifetime, despite progresses made in medical therapies. Indications for surgery include acute severe colitis with its complications, steroid-or antiTNF-refractory colitis (or growth impairment in children), and the onset of colorectal dysplasia/cancer. Recently, the introduction of biologic agents has provided a rationale for prolonging medical therapy before considering surgery in the treatment of active, moderate to severe colitis. When surgery becomes indicated, especially in the urgent setting, it usually involves dealing with immunosuppressive medications, possibly impacting the onset of post-operative septic complications. In both acute and ...
Ulcerative Colitis Market by Molecule Type (Biologics and Small Molecules), by Disease Type (Mild Ulcerative Colitis, Moderate Ulcerative Colitis, Severe Ulcerative Colitis), by Route of Administration (Oral and Injectables) - Global Opportunity Analysis and Industry Forecast, 2017-2023
291579307 - EP 1257563 A1 2002-11-20 - THERAPEUTIC AND DIAGNOSTIC METHODS FOR ULCERATIVE COLITIS AND ASSOCIATED DISORDERS - [origin: WO0158927A1] This invention relates to the field of therapy and diagnostic methods for ulcerative colitis. Specifically, the method comprises administering a compound or recombinant protein that inhibits interaction between CEP and human tropomyosin. Also included in the invention are methods to screen for drugs useful in treating ulcerative colitis and diagnostic methods for detecting diseases associated with an autoantigen response to hTM in affected tissue.[origin: WO0158927A1] This invention relates to the field of therapy and diagnostic methods for ulcerative colitis. Specifically, the method comprises administering a compound or recombinant protein that inhibits interaction between CEP and human tropomyosin. Also included in the invention are methods to screen for drugs useful in treating ulcerative colitis and diagnostic methods for detecting diseases associated
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Poor appetite, diarrhea, and poor digestion of nutrients can make it hard for people with ulcerative colitis to get the calories and nutrients the body needs.. Kids and teens with ulcerative colitis should eat a variety of foods, get plenty of fluids, and learn to avoid foods that make symptoms worse. Some may need supplements, like calcium or vitamin D. Kids who are not growing well may need additional nutrition support.. Kids and teens with ulcerative colitis can feel different and might not be able to do the things their friends can do, especially during flare-ups. Some struggle with a poor self-image, depression, or anxiety. They may not take their medicine or follow their diet. Its important to talk to your health care professional if youre concerned about your childs mood, behavior, or school performance.. Parents can help teens with ulcerative colitis take on more responsibility for their health as they get older.. Reviewed by: J. Fernando del Rosario, ...
Although previous studies have suggested that appendix seems to be involved in the colitis, the role of this in the pathogenesis remains unclear. In this study, we assessed the importance of appendiceal lymphoid follicles, specifically the cecal patches (CP) in mice, using an experimental colitis model. Treatment with oxazolone resulted in ulcerations particularly at CP with follicular expansion as well as colitis. The colitis was attenuated by either appendectomy or the absence of mature B cells. We therefore established an intravital imaging system accompanied by the fluorescence resonance energy transfer technology to analyze the dynamic immune response of CP B cells ...
OK We are kicking off Crohns and Colitis Awareness Week starting from December 1-7th. Its Awareness Week 2014, so join us! THIS JUST IN: There are now 1.6 million Americans with IBD. New York, NY-November 30, 2013- The estimated direct cost for all patients with inflammatory bowel diseases (IBD) in the US is $1.84 billion. In an effort to end inflammatory bowel disease and raise awareness for patients and families dealing with these painful, incurable diseases, the Crohns & Colitis Foundation of America (CCFA) gears up for Crohns & Colitis Awareness Week on December 1-7, 2013. "Awareness Week gives us a great opportunity to expand our reach and impact," said Richard J. Geswell, President and CEO of the Crohns & Colitis Foundation of America. "This year we are focusing on sharing some of the very exciting things that are happening on the research front. We are making tremendous progress which is why continuing to fund research is more important than ever." Known collectively as inflammatory ...
Routine fortification of food with folic acid was implemented in the U.S. in 1996 to reduce the risk of birth defects in newborns. Widespread fortification in c...
TY - JOUR. T1 - Substance P regulates Th1-type colitis in IL-10 knockout mice. AU - Weinstock, Joel V.. AU - Blum, Arthur. AU - Metwali, Ahmed. AU - Elliott, David. AU - Bunnett, Nigel. AU - Arsenescu, Razvan. PY - 2003/10/1. Y1 - 2003/10/1. N2 - Substance P (SP) is a proinflammatory molecule that interacts with a neurokinin 1 receptor (NK-1R), which is on T cells and helps control IFN-γ production. IL-10 -/- mice given a nonsteroidal anti-inflammatory drug (NSAID) develop Th1 colitis. We studied the importance of SP and NK-1R in this colitis model. LP T cells were isolated to study their NK-1R expression. LP T cells from IL-10 -/- mice expressed NK-1R and produced IFN-γ only after NSAID treatment and induction of colitis. LP T cells from NSAID-treated wild-type controls or from age-matched untreated IL-10 -/- animals did not express NK-1R or produce IFN-γ. Experiments showed that IL-12 induced NK-1R transcription in CD4 + T cells cultured in vitro. However, T cells cultured with IL-12 and ...
We demonstrate that intestinal inflammation caused by high-fat diet is increased by the environmental contaminant benzo[a]pyrene. Our in vivo results indicate that a high-fat diet (HFD) induces a pre-diabetic state in mice compared with animals fed normal chow. HFD increased IL-1betamRNA concentration in the jejunum, colon, and liver, and TNFalpha was increased in the colon and strongly increased in the liver. HFD also increased the expression of other genes related to type 2 diabetes, such as the uncoupling protein UCP2, throughout the bowel and liver, but not in the colon. The treatment of HFD with BaP enhanced the expression of IL-1beta in the liver and TNFalpha throughout the bowel and in the liver. Adding BaP to the diet also caused a significant decrease in the expression of the incretin glucagon-like peptide 1, which plays an important role in insulin secretion. Our results suggest that intestinal inflammation may be involved in the onset of type 2 diabetes and that chronic exposure to
Phytosterols, the plant analogues of cholesterol, widely occur in the human diet. In this study, we investigated and compared the effects of stigmasterol and β-sitosterol (both with purities ≥95%) on dextran sulfate sodium (DSS)-induced colitis in C57BL/6J male mice fed a high fat Western-style diet. Mice tr
Fibrates, such as fenofibrate, are peroxisome proliferator-activated receptor-α (PPARα) agonists and have been used for several decades as hypolipidemic agents in the clinic. However, contradictory observations exist on the role of fibrates in host response to acute inflammation, with unclear mechanisms. The role of PPARα in colitis was assessed using fenofibrate and Ppara-null mice. Wild-type or Ppara-null mice were subjected to acute colitis under three distinct protocols, dextran sulfate sodium, trinitrobenzenesulfonic acid, and Salmonella Typhi. Serum and colon lipidomics were analyzed to characterize the metabolic profiles by ultra-performance liquid chromatography-coupled with electrospray ionization quadrupole time-of-flight mass spectrometry. Messenger RNAs of PPARα target genes and genes involved in inflammation were determined by qunatitative PCR analysis. Fenofibrate treatment exacerbated inflammation and tissue injury in acute colitis, and this was dependent on PPARα activation.
Vanillic acid, an oxidized form of vanillin, is a benzoic acid derivative used as a flavoring agent. The objective of this study was to determine whether vanillic acid has beneficial effects against dextran sulfate sodium (DSS)-induced ulcerative colitis. Our results showed that vanillic acid reduced the severity of the clinical signs of DSS-induced colitis, including weight loss and shortening of colon length, and the disease activity index. The results of this study showed that vanillic acid significantly suppressed the expression of cyclooxygenase-2 and the activation of transcription nuclear factor-kB p65 in DSS-treated colon tissues. In addition, we observed that the plasma levels of interleukin (IL)-6 were higher in the DSS-treated group than in the control group, but these increased levels were reduced by the administration of vanillic acid. Taken together, these findings suggest that vanillic acid has a beneficial effect on DSS-induced ulcerative colitis, thereby indicating its usefulness in the
Ulcerative colitis is chronic inflammation occurring mainly in the large intestine (colon). Those with ulcerative colitis often experience frequent bowel and abdominal discomfort and diarrhea. At times, ulcerative colitis leads to more severe complications requiring immediate treatment, such as rectal bleeding, a perforated bowel or severe colon inflammation (toxic megacolon).. The cause of ulcerative colitis is unknown. It is different from irritable bowel syndrome or colitis (colon inflammation) caused by a temporary infection. While diet can make inflammation worse, it is not a cause of ulcerative colitis.. Ulcerative colitis can be controlled and your episodes of inflammation can be reduced. Our specialists at the IBD Clinic will identify what is contributing to your ulcerative colitis and help you establish a treatment plan that may include:. ...
TY - JOUR. T1 - The Role of Tumor Necrosis Factor α in Down-Regulation of Osteoblast Phex Gene Expression in Experimental Murine Colitis. AU - Uno, Jennifer K.. AU - Kolek, Olga I.. AU - Hines, Eric R.. AU - Xu, Hua. AU - Timmermann, Barbara N.. AU - Kiela, Pawel R. AU - Ghishan, Fayez K. PY - 2006/8. Y1 - 2006/8. N2 - Background & Aims: Reduced bone mass is a common complication of inflammatory bowel disease (IBD), although the mechanisms that contribute to osteopenia are not completely understood. Tumor necrosis factor α (TNF-α) is up-regulated in patients with IBD and has detrimental effects on osteoblasts. Phex gene is expressed predominantly in osteoblasts, and its disruption results in defective bone mineralization. The aim of this study was to evaluate whether TNF-α regulates Phex gene expression thus contributing to the abnormal bone metabolism observed in IBD. Methods: Phex gene expression was evaluated in calvaria of 6-7-week-old mice administered with trinitrobenzene sulfonic acid ...
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Looking for online definition of pseudomembranous colitis endoscopy prognosis in the Medical Dictionary? pseudomembranous colitis endoscopy prognosis explanation free. What is pseudomembranous colitis endoscopy prognosis? Meaning of pseudomembranous colitis endoscopy prognosis medical term. What does pseudomembranous colitis endoscopy prognosis mean?
TY - JOUR. T1 - Osteopontin mediates Citrobacter rodentium-induced colonic epithelial cell hyperplasia and attaching-effacing lesions. AU - Wine, Eytan. AU - Shen-Tu, Grace. AU - Gareau, Melanie. AU - Goldberg, Harvey A.. AU - Licht, Christoph. AU - Ngan, Bo Yee. AU - Sorensen, Esben S.. AU - Greenaway, James. AU - Sodek, Jaro. AU - Zohar, Ron. AU - Sherman, Philip M.. PY - 2010/9. Y1 - 2010/9. N2 - Although osteopontin (OPN) is up-regulated in inflammatory bowel diseases, its role in disease pathogenesis remains controversial. The objective of this study was to determine the role of OPN in host responses to a non-invasive bacterial pathogen, Citrobacter rodentium, which serves as a murine infectious model of colitis. OPN gene knockout and wild-type mice were infected orogastrically with either C. rodentium or Luria-Bertani (LB) broth. Mouse-derived OPN+/+ and OPN-/- fibroblasts were incubated with C. rodentium and attachingeffacing lesions were demonstrated using transmission electron ...

Ischemic colitis Risk factors - Mayo ClinicIschemic colitis Risk factors - Mayo Clinic

Ischemic colitis can cause pain and may damage your colon. Any part of the colon can be affected, but ischemic colitis usually ... Ischemic colitis may heal on its own. But you may need medication to treat ischemic colitis or prevent infection, or you may ... Ischemic colitis usually gets better on its own within two to three days. In more-severe cases, complications can include:. * ... Ischemic colitis that occurs in a young adult may be a sign of a blood-clotting abnormality or inflammation of the blood ...
more infohttps://www.mayoclinic.org/diseases-conditions/ischemic-colitis/basics/risk-factors/con-20026677?p=1

Microscopic Colitis Management and Treatment | Cleveland ClinicMicroscopic Colitis Management and Treatment | Cleveland Clinic

Medical Management of Microscopic Colitis. Accessed 2/15/2018.. *Microscopic Colitis Foundation. What Is Microscopic Colitis? ... How is microscopic colitis treated?. Microscopic colitis can get better on its own, but most patients have recurrent symptoms. ... The main treatment for microscopic colitis is medication. In many cases, the doctor will start treatment with an antidiarrheal ... The two steroids most often prescribed for microscopic colitis are budesonide (Entocort®) and prednisone. Budesonide is ...
more infohttps://my.clevelandclinic.org/health/diseases/17227-microscopic-colitis/management-and-treatment

Microscopic colitis syndrome. | GutMicroscopic colitis syndrome. | Gut

The analysis of the specimens for this study could delineate three distinct groups of microscopic colitis: lymphocytic colitis ... consumption and collagenous or mixed microscopic colitis. The primary cause of microscopic colitis is probably an immunological ... Hitherto undescribed flat mucosa of the ileum was found in one patient with lymphocytic colitis and both flat mucosa and ... The histological changes in the colorectum were originally diagnosed in six patients as lymphocytic colitis and in 24 patients ...
more infohttp://gut.bmj.com/content/36/6/880

AGA Microscopic Colitis Guidelines Pocket Guide and AppAGA Microscopic Colitis Guidelines Pocket Guide and App

The Microscopic Colitis GUIDELINES Pocket Card is endorsed by the American Gastroenterological Association (AGA) and was ... There are 2 subtypes: lymphocytic colitis and collagenous colitis. There is a female predominance in the latter. ... Microscopic colitis is characterized by chronic watery diarrhea caused by inflammation in the colon and diagnosed by colonic ... Microscopic colitis is not associated with increased mortality.. *The goal of medical therapy reflected in these ...
more infohttps://www.guidelinecentral.com/shop/microscopic-colitis-guidelines-pocket-card/

Metachronous occurrence of collagenous colitis and ulcerative colitis<...Metachronous occurrence of collagenous colitis and ulcerative colitis<...

"Metachronous occurrence of collagenous colitis and ulcerative colitis",. abstract = "Collagenous colitis and ulcerative colitis ... Collagenous colitis and ulcerative colitis are distinct disorders. A 67 year old woman with clinical and histological evidence ... N2 - Collagenous colitis and ulcerative colitis are distinct disorders. A 67 year old woman with clinical and histological ... AB - Collagenous colitis and ulcerative colitis are distinct disorders. A 67 year old woman with clinical and histological ...
more infohttps://jhu.pure.elsevier.com/en/publications/metachronous-occurrence-of-collagenous-colitis-and-ulcerative-col-5

Unusual presentation of nonalcoholic steatohepatitis-related cirrhosis in a patient with celiac disease and microscopic colitis...Unusual presentation of nonalcoholic steatohepatitis-related cirrhosis in a patient with celiac disease and microscopic colitis...

Stewart M, Andrews CN, Urbanski S, Beck PL, Storr M. The association of coeliac disease and microscopic colitis: A large ... Unusual presentation of nonalcoholic steatohepatitis-related cirrhosis in a patient with celiac disease and microscopic colitis ... Unusual presentation of nonalcoholic steatohepatitis-related cirrhosis in a patient with celiac disease and microscopic colitis ... Unusual presentation of nonalcoholic steatohepatitis-related cirrhosis in a patient with celiac disease and microscopic colitis ...
more infohttps://www.degruyter.com/view/j/jtim.2014.2.issue-4/2224-4018.147747/2224-4018.147747.xml

1992 - Oral mesalamine for ulcerative colitis | 1992 Jan-Feb : Volume 116, Number 1, Page 13 | ACP Journal Club Archives1992 - Oral mesalamine for ulcerative colitis | 1992 Jan-Feb : Volume 116, Number 1, Page 13 | ACP Journal Club Archives

Sulfasalazine remains a first-line drug for the treatment of ulcerative colitis. It is well tolerated by most patients and is ... To evaluate the efficacy and safety of 2 dosage levels of oral mesalamine for treating mild-to-moderate ulcerative colitis. ... Sulfasalazine is an effective treatment for ulcerative colitis, but up to one third of patients will develop side effects, some ... Oral mesalamine (Asacol) for mildly to moderately active ulcerative colitis. A multicenter study. Ann Intern Med. 1991 Sep 1; ...
more infohttp://www.acpjc.org/Content/116/1/issue/ACPJC-1992-116-1-013.htm

Accutane Ischemic Colitis | Accutane Side Effects Lawsuit, Accutane IBD Law Firm, Attorney, LawyerAccutane Ischemic Colitis | Accutane Side Effects Lawsuit, Accutane IBD Law Firm, Attorney, Lawyer

Accutane side effects include a life-threatening condition known as ischemic colitis. Contact our lawyers for information about ... Ischemic Bowel Colitis Symptoms. Common signs and symptoms of ischemic colitis include (but are not limited to): ... Ischemic colitis can affect any part of your colon, but most affected people develop pain on the left side of their abdomen. ... Ischemic colitis is a disorder in which part of your colon (large intestine) becomes inflamed and injured. In some cases, this ...
more infohttps://www.schmidtandclark.com/accutane-ischemic-bowel-colitis

MICROSCOPIC COLITIS SUPPORT :: View topic - diabetesMICROSCOPIC COLITIS SUPPORT :: View topic - diabetes

... collagenous colitis, lymphocytic colitis, gluten intolerance, autoimmune diseases, and related issues. ... This is a discussion and support forum for microscopic colitis, ... MICROSCOPIC COLITIS SUPPORT. Discussion and Support Forum for ... Lymphocytic Colitis, Microscopic Colitis, Mastocytic Enterocolitis, and Related Issues. Visit the Microscopic Colitis ... MICROSCOPIC COLITIS SUPPORT Forum Index -> Experiences That Could Only Happen To Someone Who Has MC. All times are GMT - 6 ...
more infohttp://www.perskyfarms.com/phpBB2/viewtopic.php?p=185687

Ulcerative colitis disease activity following treatment of associated primary sclerosing cholangitis with cyclosporin<...Ulcerative colitis disease activity following treatment of associated primary sclerosing cholangitis with cyclosporin<...

... colitis resulting both from improvement of moderately active colitis and from fewer flares of remission/mildly active colitis. ... colitis resulting both from improvement of moderately active colitis and from fewer flares of remission/mildly active colitis. ... colitis resulting both from improvement of moderately active colitis and from fewer flares of remission/mildly active colitis. ... colitis resulting both from improvement of moderately active colitis and from fewer flares of remission/mildly active colitis. ...
more infohttps://mayoclinic.pure.elsevier.com/en/publications/ulcerative-colitis-disease-activity-following-treatment-of-associ

MICROSCOPIC COLITIS SUPPORT :: View Forum - Current ResearchMICROSCOPIC COLITIS SUPPORT :: View Forum - Current Research

... collagenous colitis, lymphocytic colitis, gluten intolerance, autoimmune diseases, and related issues. ... This is a discussion and support forum for microscopic colitis, ... MICROSCOPIC COLITIS SUPPORT. Discussion and Support Forum for ... Lymphocytic Colitis, Microscopic Colitis, Mastocytic Enterocolitis, and Related Issues. Visit the Microscopic Colitis ... Microscopic colitis: a large retrospective analysis from a h 5. jcc. 3080. Mon Jul 13, 2009 1:42 pm. tex ...
more infohttp://www.perskyfarms.com/phpBB2/viewforum.php?f=18

IBD, Ischemic Colitis, & Abdominal Pain | LA Colorectal SurgeryIBD, Ischemic Colitis, & Abdominal Pain | LA Colorectal Surgery

IBD, Ischemic Colitis, & Abdominal Pain. Ischemic Colitis. A Painful Form Of Inflammatory Bowel Disease.. Abdominal pain often ... Who Develops Ischemic Colitis?. Men and women are equally subject to the pain associated with this disease. Ischemic colitis ... Less well known or understood is ischemic colitis. Ischemic colitis results when, for one of several reasons, there is low ... How Is Ischemic Colitis Treated?. In its early phases, bed rests and supportive care, possibly with antibiotics is instituted. ...
more infohttps://lacolon.com/article/inflammatory-bowel-disease-ischemic-colitis-abdominal-pain

How to Get Rid of Microscopic Colitis? |IYTHEALTH.comHow to Get Rid of Microscopic Colitis? |IYTHEALTH.com

Can my diet have a result on my microscopic colitis?. Microscopic colitis often improves on its own (without treatment, only by ... Microscopic colitis describes inflammation in the colon. There are two primary types: collagenous and lymphocytic. If you have ... If you have tiny colitis, these symptoms may have entered into your daily life. And you may be searching for methods to ease ... Sometimes, tiny colitis can improve by itself (without treatment, only by the Will of Allah) ...
more infohttps://iythealth.com/get-rid-microscopic-colitis/

Medical Advisor Journals, Kyle J. Norton Site, Health Tips for Better Living and Living Health: Ischemic colitis - Treatments...Medical Advisor Journals, Kyle J. Norton Site, Health Tips for Better Living and Living Health: Ischemic colitis - Treatments...

Ischemic colitis. Ischemic colitis is the most common type of intestinal ischemia. A.4.1. Non surgical treatments. Supportive ... Colitis is defined as a condition of inflammation of the large intestine, including the colon, caecum and rectum.. Treatments. ... Because ischemic colitis is a distinct subtype of ischemic bowel disease most often limited to the superficial mucosa, ... He recovered completely after surgery, and the pathological findings were consistent with ischemic colitis(96). 2. Colonoscopy ...
more infohttps://kylejnorton.blogspot.com/2013/12/ischemic-colitis-treatments-in.html

Small duct autoimmune sclerosing cholangitis and Crohn colitis in a 10-year-old child. A case report and review of the...Small duct autoimmune sclerosing cholangitis and Crohn colitis in a 10-year-old child. A case report and review of the...

22], who described a 13-year-old boy with concomitant Crohn colitis and AISC with GEL, who showed long-term remission of liver ... This report describes a rare case of AISC with concomitant Crohn colitis in a child with a unique hyperplastic and destructive ... Small duct autoimmune sclerosing cholangitis and Crohn colitis in a 10-year-old child. A case report and review of the ... Both PSC and AISC frequently occur in combination with inflammatory bowel disease (IBD) [2], typically ulcerative colitis (UC) ...
more infohttps://diagnosticpathology.biomedcentral.com/articles/10.1186/1746-1596-7-100

Mucosal cell proliferation of the rectal stump in ulcerative colitis patients after ileorectal anastomosis. | IRIS Università...Mucosal cell proliferation of the rectal stump in ulcerative colitis patients after ileorectal anastomosis. | IRIS Università...

In ulcerative colitis patients the labeling index was significantly increased, and labeled cells were shifted toward the upper ... In ulcerative colitis patients the labeling index was significantly increased, and labeled cells were shifted toward the upper ... The proliferative activity and polyamine levels of the rectal epithelium in unoperated ulcerative colitis patients and in ... The proliferative activity and polyamine levels of the rectal epithelium in unoperated ulcerative colitis patients and in ...
more infohttps://flore.unifi.it/handle/2158/329119

DSpace at EWHA: The prevalence and efficacy of ganciclovir on steroid-refractory ulcerative colitis with cytomegalovirus...DSpace at EWHA: The prevalence and efficacy of ganciclovir on steroid-refractory ulcerative colitis with cytomegalovirus...

... with moderate-to-severe active ulcerative colitis. In patients with steroid-refractory ulcerative colitis, the cytomegalovirus ... Study: A prospective, multicenter study was conducted in 72 patients with moderate-to-severe ulcerative colitis who were ... Ganciclovir was effective in patients with steroid-refractory ulcerative colitis who had a cytomegalovirus infection. Copyright ... The prevalence and efficacy of ganciclovir on steroid-refractory ulcerative colitis with cytomegalovirus infection:a ...
more infohttp://dspace.ewha.ac.kr/handle/2015.oak/222187

Microscopic Colitis Diet, Treatment, Symptoms & CausesMicroscopic Colitis Diet, Treatment, Symptoms & Causes

... lymphocytic colitis and collagenous colitis) is an inflammation of the colon. Diarrhea and abdominal pain or cramping are the ... Colitis has many different causes. Some types of colitis are contagious and some are not contagious. Symptoms of colitis ... There are many different types of colitis with different causes. Some examples of colitis include: *infectious colitis caused ... There are two types of microscopic colitis: 1) lymphocytic colitis and 2) collagenous colitis. ...
more infohttps://www.medicinenet.com/lymphocytic_colitis/article.htm

Collagenous colitis - WikipediaCollagenous colitis - Wikipedia

Ulcerative colitis. References[edit]. *^ a b c d Park, Tina; Cave, David; Marshall, Christopher (2015-08-07). "Microscopic ... Personal experience with collagenous colitis[edit]. *. Chande N, Driman DK, Reynolds RP (March 2005). "Collagenous colitis and ... Yen E. F.; Pardi D. S. (May 2011). "Microscopic Colitis - Lymphocytic, Collagenous and Mast Cell Colitis". Alimentary ... The cause of collagenous colitis is unknown.[1] Diagnosis[edit]. On colonoscopy, the mucosa of the colon typically looks normal ...
more infohttps://en.wikipedia.org/wiki/Collagenous_colitis

Diversion Colitis | SpringerLinkDiversion Colitis | SpringerLink

Nonspecific colitis of the excluded colonic segment Diversion colitis is an inflammatory process occurring in an empty colon or ... Rare cases present with fulminant colitis. It is commonly believed that diversion colitis starts in the mucosa, with damage to ... Diversion colitis is an inflammatory process occurring in an empty colon or rectum after surgical diversion of the fecal stream ... Ma, C. K., Gottlieb, C., & Haas, P. A. (1990). Diversion colitis: A clinicopathologic study of 21 cases. Human Pathology, 21, ...
more infohttps://link.springer.com/referenceworkentry/10.1007%2F978-3-319-40560-5_1436

What is colitis?What is colitis?

The term colitis refers to inflammation of the colon. It may be associated with enteritis (inflammation of the small intestine ... encoded search term (What is colitis?) and What is colitis? What to Read Next on Medscape. Related Conditions and Diseases. * ... The term colitis refers to inflammation of the colon. It may be associated with enteritis (inflammation of the small intestine ... Severe colitis noted during colonoscopy. The mucosa is grossly denuded, with active bleeding noted. This patient had her colon ...
more infohttps://www.medscape.com/answers/927845-62070/281237-overview

Colitis - Everything2.comColitis - Everything2.com

Co*litis (?), n. [NL., fr. Gr. + -itis.] Medicine|Med. An inflammation of the large intestine, esp. of its mucous membrane; coloni...
more infohttps://everything2.com/title/Colitis

Ulcerative colitis - NHS ChoicesUlcerative colitis - NHS Choices

Find out about ulcerative colitis, a long-term (chronic) condition where the colon and rectum (large intestine or large bowel) ... Symptoms of ulcerative colitis. The main symptoms of ulcerative colitis are:. *recurring diarrhoea, which may contain blood, ... What causes ulcerative colitis?. Ulcerative colitis is thought to be an autoimmune condition. This means the immune system - ... How ulcerative colitis is treated. Treatment for ulcerative colitis aims to relieve symptoms during a flare-up and prevent ...
more infohttp://www.nhs.uk/Conditions/ulcerative-colitis/Pages/Introduction.aspx

Ulcerative Colitis | HealthCentralUlcerative Colitis | HealthCentral

quiz How Much Do You Know About Ulcerative Colitis? article First in the Family with a Genetic Disease: What Its Like article ... Crohns and Ulcerative Colitis: Accepting Your Condition We are taught at a very young age not to discuss what happens behind ... the bathroom door, and even though Crohns disease and ulcerative colitis go far beyond the bathroom, patients often stay quiet ...
more infohttps://www.healthcentral.com/ulcerative-colitis?ic=also

colitis cure - Postscolitis cure - Posts

Treatments and Tools for colitis cure. Find colitis cure information, treatments for colitis cure and colitis cure symptoms. ... MedHelps colitis cure Center for Information, Symptoms, Resources, ... Posts on colitis cure. Has anybody read the 10 Day Colitis Cure Book? - Colitis Expert Forum ... Is ulcerative colitis incurable? Has anyone on this site overcome ulcerative colitis? My ... ...
more infohttp://www.medhelp.org/tags/show/145028/colitis-cure?section=subjects
  • The signs and symptoms of colitis are quite variable and dependent on the cause of the given colitis and factors that modify its course and severity. (wikipedia.org)
  • Symptoms of colitis may include: mild to severe abdominal pain and tenderness (depending on the stage of the disease), recurring bloody diarrhea with/without pus in the stools, fecal incontinence, flatulence, fatigue, loss of appetite and unexplained weight loss. (wikipedia.org)
  • Colitis interrupts the normal patterns of your dog's bowel movements and can lead to a variety of uncomfortable symptoms. (vetinfo.com)
  • Postevacuation image obtained after a single-contrast barium enema study shows extensive mucosal ulceration resulting from Shigella colitis. (medscape.com)
  • Enterohemorrhagic colitis may be caused by Shiga toxin in Shigella dysenteriae or Shigatoxigenic group of Escherichia coli (STEC), which includes serotype O157:H7 and other enterohemorrhagic E. coli. (wikipedia.org)
  • While acute colitis is something that occurs rather suddenly and may not last long, chronic colitis continues over a period of time and can continue over the span of your dog's life. (vetinfo.com)
  • If your dog suffers from acute colitis, there may not be any visible signs of a problem. (vetinfo.com)
  • Because acute colitis occurs suddenly and chronic colitis develops over time, the effect on your dog can be quite different depending on which one he is experiencing. (vetinfo.com)
  • Acute colitis typically presents itself with very few symptoms. (vetinfo.com)
  • It is commonly believed that diversion colitis starts in the mucosa, with damage to the colonic epithelium. (springer.com)
  • Diversion colitis - New light through old windows. (springer.com)
  • Diversion colitis: A clinicopathologic study of 21 cases. (springer.com)
  • Viral, bacterial and parasitic colitis can be cured with appropriate medicines. (medlineplus.gov)
  • NEC is a common cause of colitis in newborns (see the image below). (medscape.com)