Cold Ischemia
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
Ischemia
Organ Preservation
Organ Preservation Solutions
Reperfusion Injury
Raffinose
Myocardial Ischemia
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
Brain Ischemia
Delayed Graft Function
Graft Survival
Tissue Donors
Warm Ischemia
A tissue or organ remaining at physiological temperature during decreased BLOOD perfusion or in the absence of blood supply. During ORGAN TRANSPLANTATION it begins when the organ reaches physiological temperature before the completion of SURGICAL ANASTOMOSIS and ends with reestablishment of the BLOOD CIRCULATION through the tissue.
Liver Transplantation
Allopurinol
Tissue and Organ Procurement
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Common Cold
Transplantation, Isogeneic
Cryopreservation
Procaine
Tissue and Organ Harvesting
Transplants
Brain Death
A state of prolonged irreversible cessation of all brain activity, including lower brain stem function with the complete absence of voluntary movements, responses to stimuli, brain stem reflexes, and spontaneous respirations. Reversible conditions which mimic this clinical state (e.g., sedative overdose, hypothermia, etc.) are excluded prior to making the determination of brain death. (From Adams et al., Principles of Neurology, 6th ed, pp348-9)
Death
Kidney
Myocardial Reperfusion Injury
Mannitol
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
Graft Rejection
Adenosine
Rats, Wistar
Hypothermia, Induced
Rats, Sprague-Dawley
Transplantation, Homologous
Liver
Ischemic Attack, Transient
Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
Reperfusion
Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.
Disease Models, Animal
Retrospective Studies
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Liver Failure
Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
Tissue Fixation
Ischemic Preconditioning
Glutathione
Models, Animal
Immunohistochemistry
Gerbillinae
Spinal Cord Ischemia
Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.
Postoperative Complications
Myocardium
Lung Transplantation
Ischemic Preconditioning, Myocardial
Exposure of myocardial tissue to brief, repeated periods of vascular occlusion in order to render the myocardium resistant to the deleterious effects of ISCHEMIA or REPERFUSION. The period of pre-exposure and the number of times the tissue is exposed to ischemia and reperfusion vary, the average being 3 to 5 minutes.
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Treatment Outcome
P-Selectin
Transplantation Immunology
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Neuroprotective Agents
Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.
Potassium Chloride
Infarction, Middle Cerebral Artery
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
Myocardial Reperfusion
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
Specimen Handling
Intercellular Adhesion Molecule-1
Risk Factors
Adenosine Triphosphate
Histocompatibility Testing
Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)
Patient Selection
Reoperation
Survival Rate
Hindlimb
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Calcium channel blocker and renal mitochondrial function in warm renal ischemia. (1/125)
OBJECTIVE: Ions, particularly calcium ions, play an important role in ischemia-reperfusion cell injury. In this study, we investigated the action of verapamil on the mitochondrial function of kidneys submitted to ischemia without blood reperfusion in order to study isolated early and late ischemic effects. MATERIALS AND METHODS: 44 rats were submitted to bilateral warm renal ischemia for 30 minutes. The kidneys were then immediately reperfused with saline or Euro-Collins (EC) solution, with and without previous administration of 0.35 mg/kg of verapamil. Mitochondrial function was assessed at the end of renal perfusion and after 24 hours of cold preservation. RESULTS: In kidneys perfused with saline, verapamil allowed a significant early preservation of state III mitochondrial respiration, a result that was no longer evident after 24 hours. In kidneys perfused with EC solution, verapamil did not change state III for either early or late evaluations. Comparison of the groups showed that the results obtained for kidneys perfused with EC were always superior to those obtained for the saline group, except for the initial analysis of kidneys treated with saline and verapamil, which showed results similar to those obtained with EC perfusion alone. CONCLUSION: Administration of verapamil before warm ischemia provides partial and short-lasting functional protection of the mitochondrial function in kidneys perfused with sodium rich saline. With Euro-Collins solution, verapamil did not show any additional beneficial effect. This fact permits us to conclude that protective action is effective only under conditions that facilitate increased sodium uptake and/or potassium loss. (+info)Major effects of delayed graft function and cold ischaemia time on renal allograft survival. (2/125)
BACKGROUND: There is mounting evidence from experimental and clinical studies that the quality of organs from cadaver donors may be influenced by events occurring around the time of brain death, and that these may affect transplant outcome. The aim of this study is to investigate the influence of donor factors on renal allograft outcome in a homogeneous cohort of 518 patients transplanted in a single centre over a 9 year period. METHODS: Endpoints of the study were delayed graft function (DGF), acute rejection (AR), 1 year graft survival and long-term survival of those grafts that reached 1 year. Multivariate analysis was performed to determine factors that may have influenced the graft outcome indicators. RESULTS: DGF was the major predictor of graft failure overall with cold ischaemia time (CIT) as an important independent factor. The level of histocompatibility did not influence graft survival. DGF was the major factor affecting 1 year graft survival (P<0.0005) with effects persisting beyond 1 year. DGF was significantly influenced by CIT, donor age, female kidney into male recipient and donor creatinine (P<0.05). Other donor factors and factors associated with donor management were not risk factors for DGF, rejection episodes or graft survival. The risk factors for a number of AR episodes were HLA-DR mismatch and DGF (P<0.005). When grafts surviving for 1 year were considered, only CIT, recipient age and creatinine at 1 year (P<0.05) were found to affect graft survival significantly. CONCLUSIONS: The results of this analysis of well-matched transplant recipients show that CIT and DGF are the most important predictors of poor short and long-term graft survival. Therefore, in order to improve the long-term survival of renal allografts efforts should focus on limiting CIT and the damage that occurs during this period and on improving our understanding of DGF. (+info)Glycine intravenous donor preconditioning is superior to glycine supplementation to low-potassium dextran flush preservation and improves graft function in a large animal lung transplantation model after 24 hours of cold ischemia. (3/125)
OBJECTIVES: The potential role of glycine in combination with standard lung preservation with low-potassium dextran solution in lung ischemia-reperfusion injury has not been investigated in a preclinical porcine transplant model. METHODS: In a control group (n = 6), donor lungs were flushed with 1 liter of low-potassium dextran solution. In a second group (LPD-glyc, n = 6), low-potassium dextran solution was supplemented with 3.75 g of glycine. In a third group (IV-glyc, n = 6), donor preconditioning was performed by intravenous administration of 3.75 g glycine 1 hour before low-potassium dextran preservation. Grafts were stored in low-potassium dextran at 4 degrees C for 24 hours. Posttransplant graft function was assessed throughout a 7-hour observation period. RESULTS: In the control group, 2 recipients died of right-sided heart failure caused by severe ischemia-reperfusion injury. All animals of the glycine groups survived the entire observation period. Pulmonary vascular resistance remained significantly (P < .01) lower in both glycine groups when compared with controls. At the end of the observation period pulmonary vascular resistance in the control group was higher (P < .01) compared with the glycine groups (1310 +/- 319 dyn x sec x cm(-5) vs 879 +/- 127 dyn x sec x cm(-5) [LPD-glyc] vs 663 +/- 191 dyn x sec x cm(-5) [IV-glyc]). Changes of lung tissue water content were lower in the IV-glyc group compared with the LPD-control (P < .01) and LPD-glyc lungs (P < .05). Oxygenation (PO2/FiO2) was higher in the IV-glyc group compared with the LPD-glyc and control lungs (445 +/- 110 mm Hg vs 388 +/- 124 mm Hg [P < .01] vs 341 +/- 224 mm Hg [P < .001], respectively). DISCUSSION: Modification of low-potassium dextran solution with glycine or donor preconditioning ameliorates ischemia-reperfusion injury in lung transplantation. This intriguing approach merits further evaluation with respect to the mechanisms involved and may improve results in clinical lung preservation. (+info)In situ demonstration of improvement of liver mitochondria function by melatonin after cold ischemia. (4/125)
In a previous investigation, reperfusion with a melatonin-containing medium was demonstrated to enhance bile production and tissue ATP levels in rat livers, cold-preserved with University of Wisconsin (UW) or Celsior solutions, with respect to melatonin-free reperfusion; lipid peroxidation products in the perfusate were not influenced by the indole. This was ascribed to an increased efficiency of the hepatocyte mitochondria induced by melatonin. Reactive oxygen species (ROS) normally leak from the electron transfer chain in mitochondria and excessive ROS production is presumed to mediate ischemia-reperfusion (I/R) damage. A histochemical reaction was used to demonstrate ROS on the same model. Compared to the lobular zonation of ROS in control livers, the stained area of cold-preserved livers reperfused without melatonin was restricted to a narrow portal region, in keeping with the much lower ATP content. When reperfusion was performed with melatonin, the liver morphology was improved and the ROS reaction in hepatocytes more intense, though not reaching the control liver pattern. Sinusoidal cells were poorly-stained in both cases. In conclusion, with this different approach, melatonin was confirmed to improve mitochondrial performance and to discriminate parenchymal from sinusoidal cell behavior. Our observations confirm that melatonin mitigates I/R injury and support its potential in liver transplantation. (+info)Cardioprotective effects of tetrahydrobiopterin in cold heart preservation after cardiac arrest. (5/125)
BACKGROUND: It has recently been shown that tetrahydrobiopterin (BH4), an essential cofactor of nitric oxide synthase (NOS), reduces ischemia-reperfusion myocardial injury. The aim of this study was to determine if supplementation with BH4 after cardiac arrest followed by cold heart preservation would exert a cardioprotective effect against ischemia-reperfusion injury. MATERIALS AND METHODS: Isolated perfused rat hearts were subjected to 4 degrees C cold ischemia and reperfusion. Hearts were treated with cold cardioplegic solution with or without BH4 just before ischemia and during the first 5 min of reperfusion period. Effects of BH4 on left ventricular function, myocardial contents of high-energy phosphates, and nitrite plus nitrate were measured in the perfusate, before ischemia and after reperfusion. Moreover, the effect of BH4 on the cold-heart preservation followed by normothermic (37 degrees C) ischemia was determined. RESULTS: BH4 improved the contractile and metabolic abnormalities in reperfused cold preserved hearts that were subjected to normothermic ischemia. Furthermore, BH4 significantly alleviated ischemic contracture during ischemia, and restored the diminished perfusate levels of nitrite plus nitrate after reperfusion. CONCLUSION: These results demonstrated that BH4 reduces ischemia-reperfusion injury in cold heart preservation. The cardioprotective effect of BH4 implies that BH4 could be a novel and effective therapeutic option in the preservation treatment of donor heart after cardiac arrest. (+info)Mediators of rat ischemic hepatic preconditioning after cold preservation identified by microarray analysis. (6/125)
Hepatic ischemia-reperfusion injury associated with liver transplantation is an as yet unresolved problem in clinical practice. Preconditioning protects the liver against the deleterious effects of ischemia, although the mechanism underlying this preconditioning is still unclear. To profile gene expression patterns involved in hepatic ischemic preconditioning, we analyzed the changes in gene expression in rat livers by DNA microarray analysis. Approximately 116 genes were found to have altered gene expression after 8 hours of cold ischemia. Moreover, the expression of 218 genes was modified by classic preconditioning followed by the same ischemia process. Given the importance of the effects of ischemic preconditioning (IP) in minimizing the liver damage induced by sustained ischemia before reperfusion, this study analyzed the putative genes involved in the beneficial role of IP in liver grafts undergoing cold ischemia before its implantation in the recipient (IP+I). Great differences were found in the gene expression pattern of ischemic preconditioning + long cold ischemia (IP+I) group when compared with the long cold ischemia alone condition (I), which could explain the protective regulatory mechanisms that take place after preconditioning. Twenty-six genes that were downregulated in cold ischemia were found upregulated after preconditioning preceding a long cold ischemia period. These would be genes activated or maintained by preconditioning. Heat shock protein genes and 3-hydroxy-3-methylglutaryl-coenzyme A reductase are among the most markedly induced transcripts. (+info)Prolonging warm ischemia reduces the cold preservation limits of liver grafts in swine. (7/125)
BACKGROUND: The critical shortage of transplantable organs necessitates utilization of unconventional donors. But the safe time limits of cold preservation of liver grafts subjected to warm ischemia (WI) for up to 30 minutes from non-heart-beating-donors (NHBDs) has not been delineated. In this study, we investigated how the limits of cold ischemia (CI) in University of Wisconsin (UW) solution are changed in liver grafts subjected to WI from 10 to 30 minutes. METHODS: A simple porcine NHBD liver transplantation (LT) model was developed. In donors, livers were subjected to 10, 20 or 30 minutes of WI and subsequent different times of CI in UW solution. Animals were divided into three groups (WI 10 min, WI 20 min, WI 30 min, n=13 in each group) and nine subgroups (from CI 6 h to CI 28 h). One-week survival rates of recipients, hepatic function, liver energy metabolism, grafted liver microcirculation and pathological observations of the liver were compared. RESULTS: In the WI 10 min group, the one-week survival rate of the CI 20 h subgroup was significantly higher than in the other two subgroups (CI 24 h and CI 28 h) (P<0.05). Furthermore, the CI 20 h subgroup had a lower level of alanine aminotransferase (ALT), less pathological damage, a higher concentration of adenosine triphosphate (ATP) and microcirculatory blood flow in the grafted livers at 1 hour after reperfusion than the other two subgroups. The same trends were also found in the other two groups (WI 20 min and WI 30 min) and their subgroups. CONCLUSIONS: The cold preservation limits of the liver grafts shortened from 20 to 12 to 6 hours when WI time was prolonged from 10 to 20 to 30 minutes. Only the liver grafts within these time limits could be safely transplanted. (+info)Novel short-term hypothermic oxygenated perfusion (HOPE) system prevents injury in rat liver graft from non-heart beating donor. (8/125)
OBJECTIVE: To assess a machine perfusion system in rescuing liver grafts from non-heart-beating donors (NHBD). SUMMARY BACKGROUND DATA: The introduction of extracorporeal liver perfusion systems in the clinical routine depends on feasibility. Conceivably, perfusion could be performed during recipient preparation. We investigated whether a novel rat liver machine perfusion applied after in situ ischemia and cold storage can rescue NHBD liver grafts. METHODS: We induced cardiac arrest in male Brown Norway rats by phrenotomy and ligation of the subcardial aorta. We studied 2 experimental groups: 45 minutes of warm in situ ischemia + 5 hours cold storage versus 45 minutes of warm in situ ischemia + 5 hours cold storage followed by 1 hour hypothermic oxygenated extracorporeal perfusion (HOPE). In both groups, livers were reperfused in a closed sanguineous isolated liver perfusion device for 3 hours at 37 degrees C. To test the benefit of HOPE on survival, we performed orthotopic liver transplantation in both experimental groups. RESULTS: After cold storage and reperfusion, NHBD livers showed necrosis of hepatocytes, increased release of AST, and decreased bile flow. HOPE improved NHBD livers significantly with a reduction of necrosis, less AST release, and increased bile flow. ATP was severely depleted in cold-stored NHBD livers but restored in livers treated by HOPE. After orthotopic liver transplantation, grafts treated by HOPE demonstrated a significant extension on animal survival. CONCLUSIONS: We demonstrate a beneficial effect of HOPE by preventing reperfusion injury in a clinically relevant NHBD model. (+info)
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ischemic time
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University of Birmingham research gateway
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A luminance-based heart chip assay for assessing the efficacy of graft preservation solutions in heart transplantation in rats ...
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Organ procurement
For liver transplants, the cold ischemia time can be up to 24 hours, although typically surgeons aim for a much shorter period ... This time during transport is called the "cold ischemia time". Heart and lungs should have less than 6 hours between organ ... For kidney transplants, as the cold ischemia time increases, the risk of delayed function of the kidney increases. Sometimes, ... While the organ is being transported, it is either stored in an icy cold solution to help preserve it or it is connected to a ...
Uterus transplantation
Studies on cold-ischemia/eperfusion indicate an ischemic tolerance of more than 24 hours. The recipient has to look at ...
Mehmet Haberal
Until this time, kidneys came via the ETF and often had extended cold ischaemia times. Haberal had, in the interim, and before ...
Kidney Paired Donation
"Each additional hour of cold ischemia time significantly increases the risk of graft failure and mortality following renal ... Concerns regarding the negative impact that Cold Ischemic Time (CIT) may have on graft survival, due to the shipment of the ...
Intestine transplantation
Furthermore, irreversible intestinal damage is seen after approximately only 5 hours of cold ischemia in the form of mucosal ... mesenteric ischemia, motility disorder, omphalocele/gastroschisis, tumors, and volvulus. Regardless of the underlying condition ... and serum pH and lactate levels measured for evidence of intestinal ischemia. The patient's immune system is strongly modulated ... extensive venous thrombosis or arterial ischemia of the mesentery, and motility syndromes. Donated intestines, like all organs ...
Scintigraphy
Areas of infarct or ischemic tissue will remain "cold". Pre- and post-stress thallium may indicate areas that will benefit from ... This produces coronary steal from areas of ischemia where arteries are already maximally dilated. ...
Liver transplantation
... and the storage solution itself is designed to counteract the unwanted effects of cold ischemia. Although this "static" cold ... The risk of ischemic cholangiopathy increases with longer durations of cold ischemia time, which is the time that the organ ... The donor's blood in the liver will be replaced by an ice-cold organ storage solution, such as UW (Viaspan) or HTK until the ...
Cysteinyl leukotriene receptor 1
... ischemia-, and cold-induced), multiple sclerosis, auto-immune encephalomyelitis, Alzheimer's disease, and Parkinson's disease. ... and cold-air induced asthma (see Exercise-induced bronchoconstriction); and childhood sleep apnea due to adenotonsillar ...
Immortalist Society
... improve perfusion protocol and find formulations to minimize cold ischemia (a concern for organ transplantation). Dr. Pichugin ...
List of MeSH codes (E05)
... cold ischemia MeSH E05.760.833.660 - organ preservation MeSH E05.760.833.890 - semen preservation MeSH E05.799.638.231 - body ...
Penile injury
... though fewer than 16 hours of cold ischemia or 6 hours of warm ischemia leads to the best outcomes. If replantation is not ...
Surgical staple
... at the back table in cold ischemia condition for the donor organ and after native organ removal in the recipient. This is ... finalized to make as brief as possible the donor organ dangerous warm ischemia phase that can be contained in the couple of ...
List of MeSH codes (E04)
... cold ischemia MeSH E04.936.450 - organ transplantation MeSH E04.936.450.050 - bone transplantation MeSH E04.936.450.050.100 - ... warm ischemia MeSH E04.950.165 - castration MeSH E04.950.165.679 - orchiectomy MeSH E04.950.165.685 - ovariectomy MeSH E04.950. ...
Kidney ischemia
More specifically, urinary endothelin-1 levels are used as an acute marker in cold ischemic reperfusion and injury. NGAL- ... Kidney ischemia can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the ... Kidney ischemia is a disease with a high morbidity and mortality rate. Blood vessels shrink and undergo apoptosis which results ... Moreover, renal ischemia can cause the delay of graft function after renal transplant and can cause rejection of the transplant ...
Acute limb ischaemia
Symptoms of acute limb ischaemia include: Pain Pallor Paresthesias Perishingly cold Pulselessness Paralysis These symptoms are ... Renal ischemia (nephric ischemia) Mesenteric ischemia Cerebral ischemia Cardiac ischemia In order to treat acute limb ischaemia ... Acute limb ischaemia (ALI) occurs when there is a sudden lack of blood flow to a limb. Acute limb ischaemia is caused by ... The New Latin term ischaemia as written, is a British version of the word ischemia, and stems from the Greek terms ischein 'to ...
Organ donation
Location of a transplant center with respect to a donor hospital is given priority due to the effects of Cold Ischemic Time ( ... kidneys are the most resilient to ischemia.[citation needed] Kidneys packaged on ice can be successfully transplanted 24-36 ... Developments in kidney preservation have yielded a device that pumps cold preservation solution through the kidneys vessels to ... ischemia). Each organ tolerates different ischemic times. Hearts and lungs need to be transplanted within 4-6 hours from ...
Paresthesia
... which occurs when blood flow is restored after a period of ischemia, such as on rewarming after a cold episode in patients with ... A cold sore outside the mouth (not a canker sore inside the mouth) can be preceded by tingling because a cold sore is caused by ...
Drowning
... who experience cold-water drowning do not develop hypothermia quickly enough to decrease cerebral metabolism before ischemia ... The actual cause of death in cold or very cold water is usually lethal bodily reactions to increased heat loss and to freezing ... This is because cold water can have other lethal effects on the body. Hence, hypothermia is not usually a reason for drowning ... Upon submersion into cold water, remaining calm and preventing loss of body heat is paramount. While awaiting rescue, swimming ...
Ischemia
... as in acrobatics and military flying Localized extreme cold, such as by frostbite or improper cold compression therapy ... Ischemia of the small bowel is called mesenteric ischemia. Brain ischemia is insufficient blood flow to the brain, and can be ... Ischemia or ischaemia is a restriction in blood supply to tissues, causing a shortage of oxygen that is needed for cellular ... Chronic ischemia of the brain may result in a form of dementia called vascular dementia. A brief episode of ischemia affecting ...
Human serum albumin
"Ischemia-modified albumin reduction after coronary bypass surgery is associated with the cardioprotective efficacy of cold- ... including unpleasant cold allodynia in the distal extremities, mouth, and throat and usually associated with muscle cramps. ...
Organ donation
Location of a transplant center with respect to a donor hospital is given priority due to the effects of Cold Ischemic Time ( ... due to ischemia. Perfusion devices, often called kidney pumps, can extend graft survival to 36-48 hours post recovery for ... Developments in kidney preservation have yielded a device that pumps cold preservation solution through the kidneys vessels to ... ischemia). Each organ tolerates different ischemic times. Hearts and lungs need to be transplanted within 4-6 hours from ...
Erythema induratum
When weather is cold, ankle is cold, blue and often tender. In hot weather, ankle becomes hot, edematous, swollen and painful. ... Abnormal arterial supply causes low-grade ischemia of ankle region. The ankle skin becomes sensitive to temperature changes. ...
Labyrinthitis
Acute localized ischemia of these structures also may be an important cause. Especially in children, vestibular neuritis may be ... Some people will report having an upper respiratory infection (common cold) or flu prior to the onset of the symptoms of ... 30% of affected people had a common cold prior to developing the disease. Either bacterial or viral labyrinthitis can cause a ... preceded by symptoms of a common cold. However, the causative mechanism remains uncertain. This can also be brought on by ...
Livedoid dermatitis
Skin biopsies of the site show necrosis caused by ischemia. Radiographic imaging may help to delineate the extent of the wound ... or cold compresses applied to the wound. The diagnosis is mainly clinical. ... Microscopic examination of affected tissue shows ischemic necrosis, and so various hypotheses exist to explain this ischemia, ...
Intermittent claudication
"s of ischemia[citation needed] Pain Pallor (increased) Pulse (decreased) Perishing cold Paraesthesia Paralysis Most commonly, ... It is classically associated with early-stage peripheral artery disease, and can progress to critical limb ischemia unless ...
Chronic wound
... among which are ischemia, reperfusion injury, and bacterial colonization. Ischemia is an important factor in the formation and ... Blood vessels constrict in tissue that becomes cold and dilate in warm tissue, altering blood flow to the area. Thus keeping ... Like ischemia, bacterial colonization and infection damage tissue by causing a greater number of neutrophils to enter the wound ... Ischemia results from the dysfunction and, combined with reperfusion injury, causes the tissue damage that leads to the wounds ...
Alveolar osteitis
Therefore, cold fluids and foods are encouraged, which facilitate clot formation and prevent its disintegration. Avoiding ... It reduces the blood supply, leading to tissue ischemia, reduced tissue perfusion and eventually higher incidence of painful ...
Toothache
A healthy tooth will feel the cold but the pain will be mild and disappear once the stimulus is removed. The accuracy of these ... This may lead to ischemia (lack of oxygen) and necrosis (tissue death). Pulpitis is termed reversible when the inflamed pulp is ... Pulpitis is reversible when the pain is mild to moderate and lasts for a short time after a stimulus (for instance cold); or ... Hot drinks can make the tooth feel worse because they expand the gases and likewise, cold can make it feel better, thus some ...
Blue toe syndrome
... but without diffuse forefoot ischemia. The development of blue or violaceous toes can also occur with trauma, cold-induced ... Blue toe syndrome is a situation that may reflect atherothrombotic microembolism, causing transient focal ischaemia, ...
Peripheral artery disease
In individuals with severe PAD, complications may arise, including critical limb ischemia and gangrene. Critical limb ischemia ... This can lead to pain at rest, feeling of cold, or numbness in the affected foot and toes. Other complications of severe PAD ... 2016), "Critical limb ischemia: current trends and future directions", J Am Heart Assoc, 5 (2): e002938, doi:10.1161/JAHA. ... Wounds are graded 0 through 3 on the presence of ulceration and/or gangrene and ischemia. Grade 0: no ulcer, no gangrene Grade ...
Moclobemide
... also has neuroprotective properties in its demonstrated anti-hypoxia or anti-ischemia effects; there is a ... Hot flushes/cold sensation. *Photopsia. *Dyspnoea. *Visual disturbances. *Increased hepatic enzymes without associated clinical ...
Vitamin C
... and also reduced severity of colds.[7] A subset of trials reported that supplementation reduced the incidence of colds by half ... "Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia- ... the Common Cold". California and Western Medicine. 62 (6): 309-10. PMC 1781017. PMID 18747053.. ... Pauling L (1970). Vitamin C and the Common Cold (1 ed.). San Francisco: W. H. Freeman. ISBN 9780716701590. . Retrieved August ...
Angioedema
Ischemia. *Brain ischemia. *Ischaemic heart disease. *large intestine: Ischemic colitis. *small intestine: Mesenteric ischemia ... Cold intolerance. Acrocyanosis. Erythrocyanosis crurum. Radiation. Radiation poisoning. Radiation burn. Chronic radiation ...
Sheehan's syndrome
Such features include secondary hypothyroidism with tiredness, intolerance to cold, constipation, weight gain, hair loss and ... and are therefore most likely to be affected by ischemia), all the patients had growth hormone deficiency. Hormonal assay : ...
Hypoxia (medical)
Ischemia[edit]. Main article: Ischemia. Ischemia, meaning insufficient blood flow to a tissue, can also result in hypoxia. This ... If tissue is not being perfused properly, it may feel cold and appear pale; if severe, hypoxia can result in cyanosis, a blue ...
Vertigo
Any cause of inflammation such as common cold, influenza, and bacterial infections may cause transient vertigo if it involves ... and vasospasm of the blood vessels supplying the labyrinth or central vestibular pathways resulting in ischemia to these ...
Programmed cell death
New York: Cold Spring Harbor Laboratory Press. ISBN 978-0-87969-888-1. D. Bowen, Ivor (1993). Cell Biology International 17. ... "Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia". ... New York: Cold Spring Harbor Laboratory Press. ISBN 978-0-87969-887-4. Kierszenbaum, Abraham (2012). Histology and Cell Biology ...
Ephedrine
Lower than 8 mg pills are still available Otc for sinus, head colds and flu, but is completely illegal in over the counter ... Schier JG, Traub SJ, Hoffman RS, Nelson LS (2003). "Ephedrine-induced cardiac ischemia: exposure confirmed with a serum level ... colds, allergies, other disease, or traditional Asian use.[46] On April 14, 2005, the U.S. District Court for the District of ...
Disease
An acute disease is a short-lived disease, like the common cold.. Chronic disease. A chronic disease is one that lasts for a ... Included in this category are contagious diseases-an infection, such as influenza or the common cold, that commonly spreads ... For example, a common cold is a primary disease, where rhinitis is a possible secondary disease, or sequela. A doctor must ... Ischemia. *Inflammation. *Cell damage. *Wound healing. Cellular adaptation. Atrophy. Hypertrophy. Hyperplasia. Dysplasia. ...
Diabetes insipidus
Excessive urination and extreme thirst and increased fluid intake (especially for cold water and sometimes ice or ice water) ...
Stem-cell therapy
Cold Spring Harb. Symp. Quant. Biol. 73: 403-10. doi:10.1101/sqb.2008.73.018. PMID 19022746.. ... "Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats". Stroke. 32 (4 ...
Acetylcysteine
... and also ischaemia-induced brain injury. In particular, it has been demonstrated to reduce neuronal losses and to improve ...
Musculoskeletal disorder
... and extreme hot or cold temperatures can affect a worker's ability to judge force and strength, which can lead to development ... Ischemia-repurfusion injuries of the appendicular musculoskeletal system. ReferencesEdit. *^ "CDC - NIOSH Program Portfolio : ...
Pulmonary hypertension
common cold). Head. sinuses. Sinusitis. nose. Rhinitis Vasomotor rhinitis. Atrophic rhinitis. Hay fever. Nasal polyp. ...
Organ transplantation
This link is "dead cold" - archive.is, WayBack, WebCite, etc.) *^ "La ONT estima en 94.500 los transplantes de órganos solidos ... but failed due to Ischemia. Joseph Murray and J. Hartwell Harrison performed the first successful transplant, a kidney ...
Dentin hypersensitivity
Thermal - hot and cold drinks and foods,[7] cold air, coolant water jet from a dental instrument. ... will irreversibly progress to pulpal necrosis due to compression of the venous microcirculation and tissue ischemia, and ... The pain is sharp and sudden, in response to an external stimulus.[7] The most common trigger is cold,[1] with 75% of people ... Hot or cold food or drinks, and physical pressure are typical triggers in those individuals with teeth sensitivity. ...
Pituitary apoplexy
... and cold intolerance. 75% develop a deficiency to gonadotropins (LH and FSH), which control the reproductive hormone glands. ...
Myoglobin
Hardison RC (Dec 2012). "Evolution of Hemoglobin and Its Genes". Cold Spring Harb Perspect Med. 2 (12): a011627. doi:10.1101/ ... Ischemia-reperfusion injury of the appendicular musculoskeletal system. ReferencesEdit. *^ a b c GRCh38: Ensembl release 89: ...
Premature junctional contraction
... and cold water immersion.[1] If more than two such beats are seen, then the condition is termed junctional rhythm. On the ... Active ischemia. *Angina pectoris *Prinzmetal's angina. *Stable angina. *Acute coronary syndrome *Myocardial infarction ...
RICE (medicine)
Usage of a tight, non-elastic bandage will result in reduction of adequate blood flow, potentially causing ischemia. The fit ... "RICE" - Rest, Immobilize, Cold, Elevate[10]. *"HI-RICE" - Hydration, Ibuprofen, Rest, Ice, Compression, and Elevation ... To prevent localised ischemia or frostbite to the skin, it is recommended that the ice be placed within a towel or other ...
List of ICD-9 codes 710-739: diseases of the musculoskeletal system and connective tissue
Ischaemia *Avascular necrosis. *Osteonecrosis of the jaw. *Algoneurodystrophy. *Hypertrophic pulmonary osteoarthropathy. * ...
Perfusion
There is no official or formal dividing line between hypoperfusion and ischemia; sometimes the latter term refers to zero ... Poor perfusion (malperfusion), that is, ischemia, causes health problems, as seen in cardiovascular disease, including coronary ... Cold shock response. *Dead space (physiology). *Decompression (diving). *Decompression theory. *Diving reflex ...
Genetic testing
"New Orleans filmmaker cleared in cold-case murder; false positive highlights limitations of familial DNA searching". The New ... Variable degrees of hemolysis and intermittent episodes of vascular occlusion resulting in tissue ischemia and acute and ...
Accident vascular cerebral - Viquipèdia, l'enciclopèdia lliure
Algra A; Halkes, PH; Van Gijn, J [et al] «Medium intensity oral anticoagulants versus aspirin after cerebral ischaemia of ... Stroke associated with sympathomimetics contained in over-the-counter cough and cold drugs». Stroke, 34, 7, 2003, pà g. 1667-72 ... Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled ...
Transient global amnesia
Cerebral ischemia is a frequently disputed possible cause, at least for some segment of the TGA population, and until the 1990s ... The most commonly cited precipitating events include vigorous exercise (including sexual intercourse), swimming in cold water ... One current hypothesis is that TGA may be due to venous congestion of the brain, leading to ischemia of structures involved ...
Pulmonary edema
common cold). Head. sinuses. Sinusitis. nose. Rhinitis Vasomotor rhinitis. Atrophic rhinitis. Hay fever. Nasal polyp. ... Ischemia. *Brain ischemia. *Ischaemic heart disease. *large intestine: Ischemic colitis. *small intestine: Mesenteric ischemia ...
Osteomalacia
... and individuals who immigrate from warm climates to cold climates, especially women who wear traditional veils or dresses that ... Ischaemia *Avascular necrosis. *Osteonecrosis of the jaw. *Algoneurodystrophy. *Hypertrophic pulmonary osteoarthropathy. * ...
Christian J. Lambertsen
March 1961). "Cerebral ischemia and infarction". Am Pract Dig Treat. 12: 147-54. PMID 13777430.. CS1 maint: Uses authors ... Cold shock response. *Dead space (physiology). *Decompression (diving). *Decompression theory. *Diving reflex ...
Limiting Cold Ischemia Time Reduces Organ Wastage
The use of these organs could be increased if "cold ischemia times" are limited. Donated organs that could be used to save ... The process of restoring blood flow following this period of "cold ischemia" can lead to tissue damage. To examine the ... Kidney donation after circulatory death has become common in the U.S and study suggests that limiting cold ischemia time to ... Ice cream headache or brain freeze is a temporary pain due to eating or drinking a cold substance or when exposed to cold air. ...
PARP Inhibition Attenuates Histopathological Lesion in Ischemia/Reperfusion Renal Mouse Model after Cold Prolonged Ischemia
PARP Inhibition Attenuates Histopathological Lesion in Ischemia/Reperfusion Renal Mouse Model after Cold Prolonged Ischemia
i,Results,/i,. Prolonged cold ischemia time in UW solution increased PARP-1 expression and kidney injury. Preconditioning with ... In conclusion, PARP inhibition attenuates ATN and other IR-related renal lesions in mouse kidneys under prolonged cold storage ... If confirmed, these data suggest that pharmacological manipulation of PARP activity may have salutary effects in cold-stored ... and other renal lesions related to prolonged cold ischemia/reperfusion (IR) in kidneys preserved at 4°C in University of ...
Hepatic Regeneration Under Warm or Cold Ischemia Conditions: Controversies and New Approaches | IntechOpen
... the pathophysiology of liver I/R and regeneration making clear distinction between situations of cold and warm ischemia, as ... Ischemia-reperfusion (I/R) associated with hepatic resection and living related liver transplantation is an unsolved problem in ... type of ischemia applied (warm or cold), period of ischemia (ranging from minutes to days), extension of hepatic ischemia ( ... 4. Controversies on hepatic regeneration under warm or cold ischemia. In an attempt to expand the size of the donor pool, the ...
IJMS | Free Full-Text | Impact of Cold Ischemia on Mitochondrial Function in Porcine Hearts and Blood Vessels | Notes
Hearts, saphenous veins, internal-mammary-arteries and aortas of male landrace pigs were harvested and exposed to cold ischemia ... HTK-Custodiol protection of mitochondrial function after prolonged cold ischemia was observed in the myocardium but not in ... mitochondrial function remained stable even after 24 h of cold ischemia. ... Analysis of mitochondrial function can be used as a valuable approach for the assessment of cold ischemic injury in various ...
Cold Ischemia During Surgery - Semantic Scholar
Cold Ischemia During Surgery. Known as: cold ischemia In surgery, the cooling of a tissue, organ, or body part after its blood ... Laparoscopic partial nephrectomy in cold ischemia: renal artery perfusion.. *Gunter Janetschek, Alaa Eldin A. Abdelmaksoud, Dr ... We examined the effects of upregulation of heme oxygenase-1 (HO-1) in steatotic rat liver models of ex vivo cold ischemia… ( ... BACKGROUND Prolonged cold ischemia time (CIT) is accompanied by delayed cadaveric renal allograft function and early allograft ...
The effects of death and post-mortem cold ischemia on human tissue transcriptomes
CAN EFFLUENT HYALURONIC ACID OR CREATINE KINASE PREDICT SINUSOIDAL INJURY SEVERITY AFTER COLD ISCHEMIA?
Effects of warm and cold ischemia on mitochondrial functions in brain, liver and kidney | SpringerLink
... and cold (4°C) ischemia on different mitochondrial functions in rat brain, liver ... Baumann, M., Bender, E., Sömmer, G. et al. Effects of warm and cold ischemia on mitochondrial functions in brain, liver and ... Effects of warm and cold ischemia on mitochondrial functions in brain, liver and kidney. *Matthias Baumann1. , ... The purpose of this work was to study the effects of warm (37°C) and cold (4°C) ischemia on different mitochondrial functions ...
The impact of prolonged cold ischemia on delayed graft function (DGF) in pancreas transplantation.
... Roberto Troisi (UGent) , D ... Troisi R, MEESTER D, DE RYCK F, Cuvelier C, HESSE U. The impact of prolonged cold ischemia on delayed graft function (DGF) in ... R. Troisi, D. MEESTER, F. DE RYCK, C. Cuvelier, and U. HESSE, "The impact of prolonged cold ischemia on delayed graft function ... Troisi, R., MEESTER, D., DE RYCK, F., Cuvelier, C., & HESSE, U. (1999). The impact of prolonged cold ischemia on delayed graft ...
Trimetazidine Reduces Renal Dysfunction by Limiting the Cold Ischemia/Reperfusion Injury in Autotransplanted Pig Kidneys |...
However, the time of cold ischemia still has an important influence on DGF (8). Cold storage and reperfusion both cause loss of ... and protection against cold ischemia/reperfusion. The NMR spectroscopy data indicate that cold preservation of the kidneys with ... Takada M, Chandraker A, Nadeau KC, Sayegh MH, Tilney NL: The role of B7 costimulatory pathway in experimental cold ischemia/ ... Free radicals and other reactive oxygen species that trigger T cell activation (1) are produced after cold ischemia and ...
Prevention of primary graft dysfunction in lung transplantation by N-acetylcysteine after prolonged cold ischemia - Zurich...
Prevention of primary graft dysfunction in lung transplantation by N-acetylcysteine after prolonged cold ischemia ... Download PDF Prevention of primary graft dysfunction in lung transplantation by N-acetylcysteine after prolonged cold ischemia ... Prevention of primary graft dysfunction in lung transplantation by N-acetylcysteine after prolonged cold ischemia. Journal of ... and recipient treatment with NAC effectively protected the lung from primary graft dysfunction after prolonged cold ischemia. ...
PLOS ONE: Consequences of Cold-Ischemia Time on Primary Nonfunction and Patient and Graft Survival in Liver Transplantation: A...
KAKEN - Research Projects | The effect of oxygenated warm buffer perfusion with PGE1 before cold preservation on hepatic warm...
The effect of oxygenated warm buffer perfusion with PGE1 before cold preservation on hepatic warm ischemia reperfusion injury. ... Journal Article] Perfusion Using Oxygenated Buffer Containing Prostaglandin E1 before Cold Preservation Prevents Warm Ischemia- ... Presentation] Perfusion by oxygenated buffer containing prostaglandin E1 prior to cold preservation prevents warm ischemia- ... Presentation] Perfusion by oxygenated buffer containing prostaglandin E1 prior to cold preservation prevents warm ischemia- ...
Cold ischemia time | Article about cold ischemia time by The Free Dictionary
The concept of time may be discussed on several different... Explanation of cold ischemia time ... Find out information about cold ischemia time. sequential arrangement of all events, or the interval between two events in such ... redirected from cold ischemia time). Also found in: Dictionary, Thesaurus, Medical, Legal.. Related to cold ischemia time: warm ... Cold ischemia time , Article about cold ischemia time by The Free Dictionary https://encyclopedia2.thefreedictionary.com/cold+ ...
cold ischemia | CHTN Blog
Researchers have long considered the NCI supported Cooperative Human Tissue Network (CHTN) as a source for quality collection and preservation of tissue samples from remnant surgical tissue specimens. In an organized tissue procurement setting serving a large population of researchers, the trained procurement personnel, specialized reagents and monitoried frozen storage facilities assure the availability of quality research, monitored preservation techniques and temperature controlled shipping required for successful research support.. The CHTN Midwestern Division (MWD) has experienced an increase in investigator demand for fresh tissues over the past two years. Approximately 23% of the tissues distributed by the CHTN MWD is fresh tissue. Requests for frozen and formlin-fixed paraffin embedded tissues, however, remain constant and stable. The increased interest in fresh tissue likely reflects an increased focus on the study of vital cells in controlled environments for... Read more ...
Cold Ischemia | Profiles RNS
"Cold Ischemia" by people in UAMS Profiles by year, and whether "Cold Ischemia" was a major or minor topic of these publications ... Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN ... "Cold Ischemia" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Cold Ischemia" by people in Profiles over the past ten years. ...
Cold Call: Day 1 | Digital Ischemia
Digital Ischemia. 14/07/2017. Cold Call: Day 1 Filed under: Cold Call-R - Tags: audioplay, creative writing, dialogue, fiction ... Leave a Reply to Cold Call: Day 15 , Digital Ischemia Cancel reply. Enter your comment here.... ... series of telephone conversations where truth comes away in layers - begins at Cold Call: Day 1 and ends at Day […] ... series of telephone conversations where truth comes away in layers - begins at Cold Call: Day 1 and ends at Day […] ...
Cold Call: Day 14 | Digital Ischemia
... begins at Cold Call: Day 1 SOUND: PHONE RINGS LACRIMOSA: Still speaking to me? SìMON: (D) Ah, I suddenly thought oh shit, ... Digital Ischemia. 27/07/2017. Cold Call: Day 14 Filed under: Cold Call-R - Tags: comedy, creative writing, dialogue, drama, ... A series of telephone conversations where truth comes away in layers - begins at Cold Call: Day 1 ...
Cold ischaemia, innate immunity and deterioration of the glomerular filtration barrier in antibody-mediated acute rejection :...
Role of the activation of intedeukin-6/STAT3 in cholangiocyte proliferation induced by cold ischemia reperfusion and injury
... ... Conclusions IL-6/STAT3 pathway might participate to initiate cholangiecytes regeneration after cold ischemia and preservation ... Objective To investigate the role of IL-6/STAT3 pathway in the proliferation of cholangiocyte induced by cold ischemia and ... Cholangiocytes responded to extended cold preservation with severe bile duct injures and marked increase in IL-6 secretion, p- ...
Cold Ischaemia Expert for Consulting, Expert Witness
Experts available for cold ischaemia consulting, expert witness, or analyst services for business, legal, and technical ... cold ischaemia Experts. To improve your results, click a Related Expert Area on the left.. ... Join our distinguished experts for cold ischaemia jobs, projects and consulting opportunities. ...
DI-fusion OKT3 prophylaxis in Renal Grafts with prolonged cold ischemia...
Influence of Cold Ischemia Time in Kidney Transplants From Small Pediatric Donors
Clinicians may be reluctant to transplant small pediatric kidneys that have prolonged cold ischemia time (CIT) for fear of an ... Influence of Cold Ischemia Time in Kidney Transplants From Small Pediatric Donors. ... additional deleterious effect because pediatric grafts are thought to be more sensitive to ischemia. We aimed to assess the ...
Evidence of a heterogeneous tissue oxygenation: renal ischemia/reperfusion injury in a large animal model
Effects of Cold Ischemia on Tissue Oxygenation. Additionally, mean oxy-hemoglobin concentrations were compared for cold and ... Sequential oxygenation images of a left kidney at baseline (a) and during cold ischemia (b-h) and reperfusion (i-o). Ischemia ... decreases with ischemia time, and the kidney is darkest after 30 min of ischemia, demonstrating significantly lowered %. HbO. 2 ... B. R. Laneet al., "Comparison of cold and warm ischemia during partial nephrectomy in 660 solitary kidneys reveals predominant ...
Most Popular Articles : Current Opinion in Organ Transplantation
The need to reduce cold ischemia time in kidney transplantation. van der Vliet, J. Adam; Warlé, Michiel C. ... Preservation solutions for static cold storage of abdominal allografts: which is best?. Parsons, Ronald F.; Guarrera, James V. ... Role of temperature in reconditioning and evaluation of cold preserved kidney and liver grafts. Minor, Thomas; von Horn, ... Donor risk factors, retrieval technique, preservation and ischemia/reperfusion injury in pancreas transplantation. Maglione, ...
Influence of Pancreas Import and Cold Ischemia on Outcomes Following Pancreas Transplantation. - ATC Abstracts
Influence of Pancreas Import and Cold Ischemia on Outcomes Following Pancreas Transplantation.. M. Khan,1 H. El-Hennawy,1 J. ... Influence of Cold Ischemia Time in Combination With Donor Ischemic Events on Kidney Transplant Outcomes. ... Proposed changes in pancreas transplant (PT) allocation may improve organ sharing but increase cold ischemia time (CIT). ... Influence of Pancreas Import and Cold Ischemia on Outcomes Following Pancreas Transplantation. Am J Transplant. 2016;16 (suppl ...
Tumor Pre-Analytics in Molecular Pathology: Impact on Protein Expression and Analysis | SpringerLink
Cold Ischemia. The common definition for cold ischemia in surgery is the time between the chilling of a tissue, organ, or body ... The effects of warm and cold ischemia can be classified into ischemia-induced metabolic responses including posttranslational ... Effects of cold ischemia on gene expression: a review and commentary. Biopreserv Biobank. 2016;14(6):548-58.CrossRefPubMed ... Cold ischemia triggers a cascade of noxious effects and responses to hypoxia and stress, all of which affect the quality of the ...
Cellular Sources of Cytokine Production during Cold Ischemia Induced AKI after Kidney Transplant - ATC Abstracts
Phenotype and Course of Renal Tubular Cell Death during Cold Ischemia versus Cold Ischemia Followed by Transplant. ... Cellular Sources of Cytokine Production during Cold Ischemia Induced AKI after Kidney Transplant. S. Jain1, R. Plenter2, T. ... Purpose: Delayed graft function portends reduced 5-year graft survival and is associated with prolonged cold ischemia (CI). The ... Jain S, Plenter R, Nydam T, Jani A. Cellular Sources of Cytokine Production during Cold Ischemia Induced AKI after Kidney ...
The effects of death and post-mortem cold ischemia on human tissue transcriptomes. | Clinical Bioinformatics Area
ReperfusionLimiting cold ischemia timeTransplantationDelayed graft functionPreservationTimeKidneysPerfusionGraftsHepaticCardiacMyocardialAbstractOrgansLungDysfunctionHypothermiaTissue damagePathophysiologyLungsPulmonaryOccursWarm and coldOxygenSurvivalLaparoscopicDurationMitochondriaHoursLimbExposure
Reperfusion63
- Marzieh Vafapour, Mehdi Nematbakhsh, Ramesh Monajemi, Safoora Mazaheri, Ardeshir Talebi, Nahid Talebi, and Soheyla Shirdavani, "Effect of Γ-aminobutyric acid on kidney injury induced by renal ischemia-reperfusion in male and female rats: Gender-related difference. (hindawi.com)
- We test the hypothesis that PARP inhibition can decrease acute tubular necrosis (ATN) and other renal lesions related to prolonged cold ischemia/reperfusion (IR) in kidneys preserved at 4°C in University of Wisconsin (UW) solution. (hindawi.com)
- Until now, renal ischemia-reperfusion (IR) injury has been inevitable in transplantation, resulting in the cell death of renal tubular epithelial cells. (hindawi.com)
- Ischemia-reperfusion (I/R) associated with hepatic resection and living related liver transplantation is an unsolved problem in clinical practice. (intechopen.com)
- In most cases, in clinical practice, liver surgery involves both ischemia-reperfusion (I/R) injury and regeneration [ 1 ]. (intechopen.com)
- Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. (semanticscholar.org)
- H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. (semanticscholar.org)
- BACKGROUND Severe ischemia/reperfusion (IR) injury is a risk factor for delayed graft function. (semanticscholar.org)
- Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. (semanticscholar.org)
- Mitochondria play a critical role in myocardial cold ischemia-reperfusion (CIR) and induction of apoptosis. (semanticscholar.org)
- Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway. (semanticscholar.org)
- BACKGROUND Ischemia/reperfusion (I/R) injury is one of the most important causes of the early graft loss. (semanticscholar.org)
- Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury. (semanticscholar.org)
- Ischemia/reperfusion injury leads to delayed graft function, which is a major problem in kidney transplantation. (asnjournals.org)
- These results indicate that the tissue damage due to ischemia/reperfusion injury may be prevented, at least in part, by adding TMZ to preservation solutions. (asnjournals.org)
- The renal damage resulting from ischemia and reperfusion may have adverse effects on the outcome of organ transplants, increasing both posttransplant morbidity and the early loss of transplanted kidneys. (asnjournals.org)
- Cold storage and reperfusion both cause loss of cell polarity, disruption of the cytoskeleton, and perturbations in the polarized membrane transport proteins in postischemic kidneys ( 9 , 10 ). (asnjournals.org)
- Mononuclear cells (T cells and monocyte/macrophages) infiltrate postischemic rat kidneys, and the expression of T cell-associated cytokines, monocyte/macrophage activation products, and MHC class II antigen are upregulated after cold ischemia/reperfusion injury ( 11 , 12 ). (asnjournals.org)
- However, the early and late consequences of ischemia/reperfusion injury can be prevented by soluble P- and E-selectin ligand ( 11 ), or by blocking T cell costimulatory activation ( 12 ) in the absence of alloantigen. (asnjournals.org)
- This drug impairs lipid peroxidation and reduces intracellular acidosis during the cold storage and reperfusion of isolated rat kidneys ( 15 ). (asnjournals.org)
- TMZ also protects the functions of mitochondria from rat liver subjected to ischemia (30 min) and reperfusion ( 16 ). (asnjournals.org)
- In this study, we perfused rat livers from DCD before cold preservation with oxygenated warm buffer containing Prostaglandin E1 and observed bile production, liver cell death, mitochondrial function of liver cell and so on during reperfusion with oxygenated buffer. (nii.ac.jp)
- Presentation] Perfusion by oxygenated buffer containing prostaglandin E1 prior to cold preservation prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors. (nii.ac.jp)
- Objective To investigate the role of IL-6/STAT3 pathway in the proliferation of cholangiocyte induced by cold ischemia and reperfusion injury. (oriprobe.com)
- To better understand the dynamics of intraoperative renal ischemia and recovery of renal oxygenation during reperfusion, a visible reflectance imaging system (VRIS) was developed to measure renal oxygenation during renal artery clamping in both cooled and warm porcine kidneys. (spiedigitallibrary.org)
- Cold ischemia/reperfusion injury of the hepatic graft has been attributed to the release of various inflammatory cytokines. (elsevier.com)
- Decoy ODNs against nuclear factor-κB binding site delivery improved the viability of the hepatic graft against cold ischemia/reperfusion injury in the rodent liver transplantation model. (elsevier.com)
- The extent of graft damage after ischemia-reperfusion reflects the balance between deleterious events and protective factors. (asnjournals.org)
- For investigating whether HO-1 and VEGF play a role in the adaptive response to ischemia-reperfusion injury after renal transplantation, kidney biopsies were analyzed from living ( n = 45) and cadaveric ( n = 16) donors, obtained at three time points: at the end of cold storage T(−1), after warm ischemia T(0), and after reperfusion T(+1). (asnjournals.org)
- It is concluded that the lower expression of HO-1, VEGF 165 , and Bcl-2 in cadaveric donor kidneys can reflect a defective adaptation against ischemia-reperfusion injury that may affect their function in the short term. (asnjournals.org)
- An appropriate protective response may tip the balance toward a less hazardous event related to the damage of ischemia-reperfusion process. (asnjournals.org)
- Acute ischemia - reperfusion (I/R) of extremities means serious challenge in the clinical practice. (bvsalud.org)
- Before operations, from the excluded limb by the end of ischemia , during the reperfusion , and for 5 postoperative days afterwards blood samples were collected for testing hematological and blood coagulation parameters . (bvsalud.org)
- Cold storage (CS) remains the gold standard for organ preservation worldwide, although it is inevitably associated with ischemia/reperfusion injury (IRI). (fujita-hu.ac.jp)
- The fragility of the lungs limits the procurement rate and can favor the occurrence of ischemia-reperfusion injury (IRI). (elsevier.com)
- Numerous pharmacological interventions aiming to prevent ischemia-reperfusion injuries failed to reduce the rate of DGF. (springer.com)
- During the transplantation procedure, the kidneys suffer from warm (harvesting and grafting before vascular anastomosis) and cold ischemia (preservation) followed by reperfusion. (springer.com)
- The association of hypoxic and ischemia-reperfusion injuries decreases renal blood flow, increases oxidative stress and triggers the release of pro-inflammatory mediators which activate leukocyte adhesion and immune phenomena. (springer.com)
- Mitochondria play a central role in the pathophysiology of ischemia-reperfusion injuries. (springer.com)
- Here we demonstrate that in contrast to the proinflammatory role of HMGB1, preconditioning with HMGB1 results in protection following hepatic ischemia/reperfusion (I/R). Pretreatment of mice with HMGB1 significantly decreased liver damage after I/R. The protection observed in mice pretreated with HMGB1 was associated with a higher expression of IL-1R-associated kinase-M, a negative regulator of TLR4 signaling, compared with controls. (jimmunol.org)
- Ischemia/reperfusion (I/R) 4 injury is a pathophysiologic process whereby hypoxic organ damage is accentuated following return of blood flow and oxygen delivery. (jimmunol.org)
- HMGB1 levels are increased by ischemia/reperfusion in the liver and activation of the innate immune system by HMGB1 in this context requires TLR4-dependent signaling. (jimmunol.org)
- In kidney transplantation, injury due to ischemia and reperfusion is an inevitable process resulting many times in delayed graft function (DGF) that is currently characterized by the need of dialysis within the first week after transplantation. (scielo.br)
- Ischemia and reperfusion injury (IRI) also promotes activation of the innate and adaptive responses of the immune system, leading to processes with great potential to produce significant graft harm. (scielo.br)
- To elucidate the role of DAP12 in pulmonary ischemia/reperfusion injury (IRI), we took advantage of a clinically relevant mouse model of transplant-mediated lung IRI. (jimmunol.org)
- Ischemia/reperfusion injury (IRI) is a clinically relevant noninfectious inflammatory insult that can affect a variety of tissues. (jimmunol.org)
- In the case of lung transplantation, where reperfusion of a lung transiently subjected to cold ischemia is an inherent component of this procedure, IRI is a critical determinant of short- and long-term morbidity and mortality ( 3 ). (jimmunol.org)
- He is interested in the pathogenesis of kidney ischemia-reperfusion injury and transplant rejection, and molecular control of urinary malignancies. (vchri.ca)
- Reduction of cold ischemia-reperfusion injury by graft-expressing clusterin in heart transplantation. (vchri.ca)
- Expression of transforming growth factor-beta1 limits renal ischemia-reperfusion injury. (vchri.ca)
- Loss of clusterin expression worsens renal ischemia-reperfusion injury. (vchri.ca)
- Among abdominal solid organ transplantation, pancreatic grafts are prone to develop severe ischemia reperfusion injury-associated graft damage, leading eventually to early graft loss. (jove.com)
- The chronological expression (over 24 h) of two adhesion molecules [intercellular adhesion molecule-1 (ICAM-1) and CD11b/CD18 (Mac-1)] and the extent of liver damage, including injury to sinusoidal endothelial cells (SECs) and hepatocyte apoptosis, were investigated under two conditions of rat liver ischemia-reperfusion (I/R) injury: reversible (30 min) and fatal I/R (60 min). (physiology.org)
- hepatic injury induced by ischemia-reperfusion (I/R) is an important clinical problem that often follows circulatory shock with resuscitation, as well as many types of liver surgery, including transplantation and tumor resection. (physiology.org)
- Rationale Primary graft dysfunction in lung transplant recipients derives from the initial, largely leukocyte-dependent, ischaemia-reperfusion injury. (bmj.com)
- Intravascular lung-marginated monocytes have been shown to play key roles in experimental acute lung injury, but their contribution to lung ischaemia-reperfusion injury post transplantation is unknown. (bmj.com)
- Methods Isolated perfused C57BL/6 murine lungs were subjected to warm ischaemia (2 hours) and reperfusion (2 hours) under normoxic conditions. (bmj.com)
- Results In mouse lungs following ischaemia-reperfusion, substantial numbers of lung-marginated monocytes remained within the pulmonary microvasculature, with reduced L-selectin and increased CD86 expression indicating their activation. (bmj.com)
- Conclusions These results indicate that lung-marginated intravascular monocytes are retained as a 'passenger' leukocyte population during lung transplantation, and play a key role in the development of transplant-associated ischaemia-reperfusion injury. (bmj.com)
- Resident lung mononuclear phagocytes have been implicated in ischaemia-reperfusion injury and the development of primary graft dysfunction following lung transplantation, but the contribution of lung intravascular monocytes to lung transplant-related injury is not known. (bmj.com)
- This study suggests that vascular monocytes play a key role in lung injury following ischaemia-reperfusion. (bmj.com)
- Graft cellular death was an early event detected at H3 and seems to be one of the first ischemia reperfusion injuries. (biomedcentral.com)
- Donor deceased after cardiac death (DCD), is an additional potential source of kidney graft which is more prone to severe ischemia reperfusion injury (IRI), primary non-function (PNF), and delayed graft function (DGF). (biomedcentral.com)
Limiting cold ischemia time1
- Kidney donation after circulatory death has become common in the U.S and study suggests that limiting cold ischemia time to less than 12 hours can reduce kidney wastage. (medindia.net)
Transplantation26
- If confirmed, these data suggest that pharmacological manipulation of PARP activity may have salutary effects in cold-stored organs at transplantation. (hindawi.com)
- Acute tubular necrosis (ATN) induced by IR injury contributes to the development of delayed graft function (DGF), which remains an important complication of kidney transplantation and, despite advances in cold storage, is a major risk factor for acute rejection and long-term kidney allograft dysfunction [ 3 ]. (hindawi.com)
- The impact of prolonged cold ischemia on delayed graft function (DGF) in pancreas transplantation. (ugent.be)
- Troisi R, MEESTER D, DE RYCK F, Cuvelier C, HESSE U. The impact of prolonged cold ischemia on delayed graft function (DGF) in pancreas transplantation. (ugent.be)
- Improvements in cold preservation techniques and solutions, such as the University of Wisconsin (UW) solution, have greatly facilitated the use of organs, including kidneys, for transplantation. (asnjournals.org)
- METHODS: Porcine single left-lung transplantation was performed in 2 experimental groups after 24 hours of cold storage. (uzh.ch)
- The liver grafts which are taken from the donors after cardiac death(DCD)and preserved immediately in cold solution show bad function after transplantation. (nii.ac.jp)
- Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures. (uams.edu)
- Lo S, MacMillan-Crow LA, Parajuli N. Renal cold storage followed by transplantation impairs proteasome function and mitochondrial protein homeostasis. (uams.edu)
- In renal transplantation, cold ischaemia (CI) determines acute rejection through innate immunity among others. (oup.com)
- Conclusions IL-6/STAT3 pathway might participate to initiate cholangiecytes regeneration after cold ischemia and preservation injury,which might benefit biliary recovery after fiver transplantation. (oriprobe.com)
- Renal ischemia that occurs intraoperatively during procedures requiring clamping of the renal artery (such as renal procurement for transplantation and partial nephrectomy for renal cancer) is known to have a significant impact on the viability of that kidney. (spiedigitallibrary.org)
- Influence of Pancreas Import and Cold Ischemia on Outcomes Following Pancreas Transplantation. (atcmeetingabstracts.com)
- Khan M, El-Hennawy H, Rogers J, Farney A, Orlando G, Reeves-Daniel A, Palanisamy A, Stratta R. Influence of Pancreas Import and Cold Ischemia on Outcomes Following Pancreas Transplantation. (atcmeetingabstracts.com)
- Cold ischemia time and allograft outcomes in live donor renal transplantation: Is live donor organ transport feasible? (uab.edu)
- While transport of the kidney is an attractive alternative, there is concern that prolonged cold ischemia time (CIT) would diminish the benefits of live donor transplantation (LDTx). (uab.edu)
- In rat liver transplantation, the addition of VEGF to cultured sinusoidal endothelial cells attenuated the damage induced by cold preservation, inhibiting cellular apoptosis ( 17 ), which is possibly mediated by the increased expression of the antiapoptotic proteins such as A1 and Bcl-2 ( 18 ). (asnjournals.org)
- Transient episodes of ischemia are encountered during solid organ transplantation, trauma, hypovolemic shock, and elective liver resection, when inflow occlusion or total vascular exclusion is used to minimize blood loss. (jimmunol.org)
- This large international trial could be the defining work towards establishing ex-vivo heart perfusion as a viable clinical option for donor heart preservation for transplantation to overcome the challenges of cold ischemic storage,' said Dr. Waleed Hassanein , President and CEO of TransMedics, Inc. (prnewswire.com)
- Since the advent of organ transplantation, the cornerstone of organ preservation has been cold ischemic storage (essentially placing organs on ice). (prnewswire.com)
- Partly because of the limitations of cold storage, it is estimated that globally 70% to 80% of donor hearts cannot ultimately be used for transplantation. (prnewswire.com)
- TransMedics has developed the world's only portable medical device capable of overcoming the limitations of cold storage for organ transplantation. (prnewswire.com)
- The injury an organ sustains during recovery, preservation, and transplantation occurs primarily as a result of ischemia and hypothermia. (medscape.com)
- The second, the cold ischemic phase, occurs when the organ is preserved in a hypothermic state prior to transplantation into the recipient. (medscape.com)
- Deciphering the respective role of renal warm and cold ischemia is of pivotal interest in the transplantation process. (biomedcentral.com)
- Using a preclinical pig model of renal auto-transplantation, we investigated the consequences of warm and cold ischemia on early innate and adaptive responses as well as graft outcome. (biomedcentral.com)
Delayed graft function1
- Delayed graft function portends reduced 5-year graft survival and is associated with prolonged cold ischemia (CI). (atcmeetingabstracts.com)
Preservation8
- Currently, the most effective preservation strategy to reduce ischemic injury during prolonged cold storage is to decrease renal oxygen demand by using both hypothermia and preservation solutions (University of Wisconsin (UW) solution) together. (hindawi.com)
- Organ preservation solutions play an important role in the prevention of DGF, especially in organs from expanded criteria donors or exposed to prolonged cold ischemia. (hindawi.com)
- Cholangiocytes responded to extended cold preservation with severe bile duct injures and marked increase in IL-6 secretion, p-STAT3 and cyclinDl protein expression, followed by compensatory cholangiocytes regeneration. (oriprobe.com)
- ABSTRACT Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia . (bvsalud.org)
- Thirty minutes after cardiac arrest, in situ anterograde selective pulmonary cold perfusion Show more The aim of this study was to assess the functional preservation of the lung graft with anterograde lung perfusion in a model of donation after cardiac death. (univoak.eu)
- [ 3 ] Organ ischemia and preservation disrupt all these relations. (medscape.com)
- Decrease in donor heart injury by recombinant clusterin protein in cold preservation with University of Wisconsin solution. (vchri.ca)
- In such donors, different ischemic conditions are associated such as warm ischemia (WI) and cold ischemia (CS) characterized respectively by an ischemic period at body temperature initiated by cardiac arrest ensuing a low and/or no blood flow and by a hypothermic preservation of kidneys. (biomedcentral.com)
Time28
- Certain DCD kidneys were at higher risk of failing when compared with kidneys from brain dead donors, but only when the cold ischemia time was >12 hours. (medindia.net)
- Prolonged cold ischemia time in UW solution increased PARP-1 expression and kidney injury. (hindawi.com)
- The impact of ischemia time during open nephron sparing surgery on solitary kidneys: a multi-institutional study. (semanticscholar.org)
- The cold ischemia time (CIT) was recorded. (ovid.com)
- However, the time of cold ischemia still has an important influence on DGF ( 8 ). (asnjournals.org)
- 5 Two major modifiable intraoperative variables known to affect renal function during ischemia are the length of ischemic time and the temperature of the kidney at which ischemia occurred. (spiedigitallibrary.org)
- Clinicians may be reluctant to transplant small pediatric kidneys that have prolonged cold ischemia time (CIT) for fear of an additional deleterious effect because pediatric grafts are thought to be more sensitive to ischemia. (ovid.com)
- Proposed changes in pancreas transplant (PT) allocation may improve organ sharing but increase cold ischemia time (CIT). (atcmeetingabstracts.com)
- The highest values were on the 2nd day in cold I/R group, accompanied by increased prothrombin time values. (bvsalud.org)
- Adenosine triphosphate (ATP) depletion during cold ischemia time (CIT) is considered crucial for graft function. (unipd.it)
- 1 h, however, little has been published about cold ischemia time and its significance in ERBB2 testing. (houstonmethodist.org)
- To that end, this study evaluated ERBB2 status using two different FDA-approved in-situ hybridization methods and an FDA-approved immunohistochemistry (IHC) assay in the largest cohort to date (n=84) of invasive breast carcinomas with tracked cold ischemia time. (houstonmethodist.org)
- Fluorescence in-situ hybridization (FISH) and INFORM HER2 ® demonstrated 100% concordance in the detection of ERBB2 amplification by all three scoring guidelines at all cold ischemia time points. (houstonmethodist.org)
- In addition, Inform HER2 ® in-situ hybridization signals were significantly more intense than FISH at all cold ischemia time points, however, no significant loss of either chromosome 17 or ERBB2 signal was detected by FISH or Inform HER2 ® in-situ hybridization in cold ischemia times up to 3 h. (houstonmethodist.org)
- On the basis of our findings, cold ischemia time up to 3 h has no deleterious effect on the detection of ERBB2 via in-situ hybridization or IHC. (houstonmethodist.org)
- The mean cold ischemia time was 31.4 +/- 8.4 hr. (nih.gov)
- Cold ischemia time greater than 40 hours. (clinicaltrials.gov)
- For example, livers from African American and female donors were associated with significantly higher risk of graft failure, as were livers with cold ischemia time longer than 8.8 hours. (medpagetoday.com)
- Although all the variables included in the model are important, donor age, cold ischemia time, recipient MELD score, and cause of liver disease have the greatest impact on survival. (medpagetoday.com)
- In treating acute limb ischaemia time is everything. (wikipedia.org)
- The warm ischemia time was 5 minutes. (urofrance.org)
- The cold ischemia time was 58 minutes. (urofrance.org)
- cold ischemia time the time between the placement of a traumatically amputated body part in ice and the time of surgical replantation. (thefreedictionary.com)
- warm ischemia time the time interval between traumatic amputation of a limb or part and its placement on ice. (thefreedictionary.com)
- Myocardial ischemia can develop slowly as arteries become blocked over time. (mayoclinic.org)
- We achieved a favorable osteosynthesis, a functional cascade, and perfusion of the allograft in 5.5 hours of cold ischemia time. (aaps1921.org)
- For liver transplants, the cold ischemia time can be up to 24 hours, although typically surgeons aim for a much shorter period of time. (wikipedia.org)
- For kidney transplants, as the cold ischemia time increases, the risk of delayed function of the kidney increases. (wikipedia.org)
Kidneys12
- We found that use of DCD kidneys is variable throughout the United States, that the outcomes are generally excellent, and that the use of these organs could probably be safely increased if cold ischemia times are limited," said Dr. Gill. (medindia.net)
- In conclusion, PARP inhibition attenuates ATN and other IR-related renal lesions in mouse kidneys under prolonged cold storage in UW solution. (hindawi.com)
- This study investigated the effects of adding trimetazidine (TMZ) to the perfusate of cold-stored kidneys on the function of reperfused autotransplanted pig kidney. (asnjournals.org)
- The left kidney was removed and cold-flushed with Euro-Collins (EC), or University of Wisconsin (UW) solutions with or without 10 -6 M TMZ and stored for 48 h at 4°C. The kidneys were then autotransplanted and the contralateral kidneys were removed. (asnjournals.org)
- it was 100% for pigs having kidneys cold-flushed with TMZ-supplemented UW and EC solutions. (asnjournals.org)
- The functions of the transplanted kidneys were also better preserved after cold flush with TMZ-supplemented solutions than with TMZ-free solutions. (asnjournals.org)
- Creatinine clearance was higher and the urinary excretion of trimethylamine- N -oxide and dimethylamine, used as markers of renal medulla injury, were lower in animals transplanted with kidneys cold-flushed with TMZ-supplemented solutions than with TMZ-free solutions. (asnjournals.org)
- The anti-ischemic drug trimetazidine (TMZ) has been shown to improve the function of isolated perfused pig kidneys exposed to prolonged cold ischemia ( 14 ). (asnjournals.org)
- Mean relative oxy-hemoglobin concentrations decrease more significantly during ischemia for normothermic kidneys compared to hypothermic kidneys. (spiedigitallibrary.org)
- 13% of the cadaveric kidneys were from pediatric donors less than 3 years of age and were transplanted en bloc. (nih.gov)
- Patients who are recipients of multiple solid organ transplants, including dual and en bloc kidneys, or who have previously received transplanted organs. (clinicaltrials.gov)
- Kidneys were subjected to either 60 min-warm ischemia (WI) or auto-transplanted after cold storage for 24 h at 4°C (CS), or both conditions combined (WI + CS). (biomedcentral.com)
Perfusion5
- Laparoscopic partial nephrectomy in cold ischemia: renal artery perfusion. (semanticscholar.org)
- Early Intraductal L-Glutamine Perfusion Improves Pig Islet Isolation Outcome After Warm and Cold Ischemia. (ox.ac.uk)
- Thirty minutes after cardiac arrest, in situ anterograde selective pulmonary cold perfusion was started in six swine. (univoak.eu)
- Based on this, there is a need for uniform perfusion settings (perfusion route and duration), and the development of general guidelines regarding the duration of cold storage in context of the overall donor risk is also required to better compare various trial results. (mdpi.com)
- While the organ is being transported, it is either stored in an icy cold solution to help preserve it or it is connected to a miniature organ perfusion system which pumps an icy solution (sometimes enriched with potassium) through the organ. (wikipedia.org)
Grafts4
- DI-fusion OKT3 prophylaxis in Renal Grafts with prolonged cold ischemia. (ac.be)
- The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times . (bvsalud.org)
- Cold Ischemia And Renal Graft Survival: A Paired Analysis Comparing First And Second Grafts From The Same Donor. (com.es)
- OBJECTIVE: To compare the characteristics, clinical course, and survival of pairs of renal grafts from the same donor, with special interest in cold ischemia times (CIT) as a risk factor for graft survival. (com.es)
Hepatic2
- To overcome such obstacles, we developed a novel reconditioning method for donor organs named hydrogen flush after cold storage (HyFACS), which is just an end-ischemic H 2 flush directly to donor organs ex vivo, and, herein, we report its therapeutic impact against hepatic IRI. (fujita-hu.ac.jp)
- After 24-hour CS in UW solution, livers were cold-flushed with H 2 solution (1.0 ppm) via the portal vein (PV), the hepatic artery (HA), or both (PV + HA). (fujita-hu.ac.jp)
Cardiac2
- In addition to limb ischemia, other organs can become ischemic, causing: Renal ischemia (nephric ischemia) Mesenteric ischemia Cerebral ischemia Cardiac ischemia In order to treat acute limb ischaemia there are a series of things that can be done to determine where the occlusion is located, the severity, and what the cause was. (wikipedia.org)
- Myocardial ischemia, also called cardiac ischemia, reduces the heart muscle's ability to pump blood. (mayoclinic.org)
Myocardial13
- Why does Exercise in Cold Air Increase Susceptibility to Myocardial Ischaemia? (vumc.nl)
- Cold stress may also be used to model conditions where increases in myocardial oxygen demand are not met by anticipated increases in coronary blood flow, as occurs in older adults. (cdc.gov)
- Myocardial ischemia occurs when blood flow to the heart muscle (myocardium) is obstructed by a partial or complete blockage of a coronary artery by a buildup of plaques (atherosclerosis). (mayoclinic.org)
- Myocardial ischemia occurs when blood flow to your heart is reduced, preventing the heart muscle from receiving enough oxygen. (mayoclinic.org)
- Myocardial ischemia might also cause serious abnormal heart rhythms. (mayoclinic.org)
- Treatment for myocardial ischemia involves improving blood flow to the heart muscle. (mayoclinic.org)
- Making heart-healthy lifestyle choices is important in treating and preventing myocardial ischemia. (mayoclinic.org)
- Some people who have myocardial ischemia don't have any signs or symptoms (silent ischemia). (mayoclinic.org)
- Myocardial ischemia occurs when the blood flow through one or more of your coronary arteries is decreased. (mayoclinic.org)
- Atherosclerosis is the most common cause of myocardial ischemia. (mayoclinic.org)
- The clot might block an artery and lead to sudden, severe myocardial ischemia, resulting in a heart attack. (mayoclinic.org)
- Coronary artery spasm is an uncommon cause of myocardial ischemia. (mayoclinic.org)
- Type 1 and type 2 diabetes are linked to an increased risk of myocardial ischemia, heart attack and other heart problems. (mayoclinic.org)
Abstract1
- Jain S, Plenter R, Nydam T, Jani A. Cellular Sources of Cytokine Production during Cold Ischemia Induced AKI after Kidney Transplant [abstract]. (atcmeetingabstracts.com)
Organs3
- The use of these organs could be increased if "cold ischemia times" are limited. (medindia.net)
- Given its safety, simplicity, and cost-effectiveness, end-ischemic HyFACS may be a novel pretransplant conditioning for cold-stored donor organs. (fujita-hu.ac.jp)
- Scientists also did not repeat Dr. Suda's success for other organs those are more resistant to cold storage and freezing than the brain. (cryonics.org)
Lung2
- CONCLUSION: In this model, donor and recipient treatment with NAC effectively protected the lung from primary graft dysfunction after prolonged cold ischemia. (uzh.ch)
- In this study, we investigated the paracrine effects of human amnion-derived MSCs (hAMSCs) in an in vitro model of lung IRI that includes cold ischemia and normothermic EVLP. (elsevier.com)
Dysfunction1
- It therefore appears that hypothermia can prevent effectively mitochondrial dysfunction due to ischemia. (springer.com)
Hypothermia1
- Ischemia Modified by Topical Hypothermia. (indigo.ca)
Tissue damage1
- The process of restoring blood flow following this period of "cold ischemia" can lead to tissue damage. (medindia.net)
Pathophysiology1
- Signaling pathways regarding the pathophysiology of liver I/R and regeneration making clear distinction between situations of cold and warm ischemia, as well as liver regeneration with or without vascular occlusion, will be addressed. (intechopen.com)
Lungs1
- Macrophages in both mouse and human lungs that have been subjected to cold ischemic storage express DAP12. (jimmunol.org)
Pulmonary1
- We conclude that vaporized PFC reduces the production of free radicals and the number of pulmonary structural changes resulting from cold ischemia . (bvsalud.org)
Occurs1
- Acute limb ischaemia (ALI) occurs when there is a sudden lack of blood flow to a limb. (wikipedia.org)
Warm and cold3
- The same procedures with cooling using ice bags, as well as warm and cold sham-operations were performed. (bvsalud.org)
- 3. The study of warm and cold ischemia of rat brain tissues. (cryonics.org)
- it is the sum of warm and cold ischemia times. (thefreedictionary.com)
Oxygen1
- Oxygen imbalance causes ISCHEMIA. (brainscape.com)
Survival1
- Cold ischemia and the reduced long-term survival of cadaveric renal allografts. (semanticscholar.org)
Laparoscopic1
- VRIS may be broadly applicable to provide an indicator of organ ischemia during open and laparoscopic procedures. (spiedigitallibrary.org)
Duration2
- PURPOSE The safe duration of ischemia during nephron sparing surgery remains controversial. (semanticscholar.org)
- 12 There remains much controversy as to the specific duration of ischemia that results in renal injury and at what point cold ischemia should be employed. (spiedigitallibrary.org)
Mitochondria1
- After l0 to 60 minutes of ischemia at 37°C the energy coupled respiration as well as the ADP-induced malate-aspartate shuttle activity in brain and liver mitochondria or the rate of mitochondrial ATP synthesis in kidney were significantly decreased. (springer.com)
Hours4
- It was 72% for 2 hours of warm ischemia and only 50% for 3 hours of warm exposure. (cryonics.org)
- Brain slice viability was 80% of the control for 3 hours of cold (4oC) ischemia without warm ischemia. (cryonics.org)
- It was 74% for 6 hours of cold ischemia, 59% for 12 hours, 50% for 18 hours, 43% for 24 hours, and 0% for 48 hours of cold exposure. (cryonics.org)
- In some cases, gangrene can occur within six hours of ischaemia. (wikipedia.org)
Limb9
- These results indicate the risk of coagulopathy following limb I/R on early post-eventually days, which risk is higher in the case of cold I/R. (bvsalud.org)
- Acute limb ischaemia is caused by embolism or thrombosis, or rarely by dissection or trauma. (wikipedia.org)
- In this sense, ischaemia refers to the inhibition of blood flow to/through the limb. (wikipedia.org)
- Acute limb ischaemia can occur in patients through all age groups. (wikipedia.org)
- Patients that smoke and have diabetes mellitus are at a higher risk of developing acute limb ischaemia. (wikipedia.org)
- When a limb is ischemic in the non-acute (chronic) setting, the condition is alternatively called peripheral artery disease or critical limb ischemia, rather than ALI. (wikipedia.org)
- In the worst cases acute limb ischaemia progresses to critical limb ischaemia, and results in death or limb loss. (wikipedia.org)
- Compartment syndrome can occur because of acute limb ischaemia because of the biotoxins that accumulate distal to the occlusion resulting in edema. (wikipedia.org)
- The primary intervention in acute limb ischaemia is emergency embolectomy using a Fogarty Catheter, providing the limb is still viable within the 4-6h timeframe. (wikipedia.org)
Exposure2
- Greater length of renal ischemia is associated with subsequent worse recovery of renal function, whereas cooling of the kidney allows for longer exposure to ischemia. (spiedigitallibrary.org)
- Exposure to acute heat or cold stress elicits numerous physiological responses aimed at maintaining body temperatures. (cdc.gov)