The transference of a part of or an entire liver from one human or animal to another.
Non-cadaveric providers of organs for transplant to related or non-related recipients.
Repair or renewal of hepatic tissue.
Progressive destruction or the absence of all or part of the extrahepatic BILE DUCTS, resulting in the complete obstruction of BILE flow. Usually, biliary atresia is found in infants and accounts for one third of the neonatal cholestatic JAUNDICE.
Excision of all or part of the liver. (Dorland, 28th ed)
The chilling of a tissue or organ during decreased BLOOD perfusion or in the absence of blood supply. Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
The metabolic process of all living cells (animal and plant) in which oxygen is used to provide a source of energy for the cell.
Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).
The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)
Solutions used to store organs and minimize tissue damage, particularly while awaiting implantation.
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
A trisaccharide occurring in Australian manna (from Eucalyptus spp, Myrtaceae) and in cottonseed meal.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.
Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.
The transference of a kidney from one human or animal to another.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The process by which organs are kept viable outside of the organism from which they were removed (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
General dysfunction of an organ occurring immediately following its transplantation. The term most frequently refers to renal dysfunction following KIDNEY TRANSPLANTATION.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
A tissue or organ remaining at physiological temperature during decreased BLOOD perfusion or in the absence of blood supply. During ORGAN TRANSPLANTATION it begins when the organ reaches physiological temperature before the completion of SURGICAL ANASTOMOSIS and ends with reestablishment of the BLOOD CIRCULATION through the tissue.
Techniques using a laser to cut away and harvest a specific cell or cluster of cells from a tissue section while viewing it under the microscope.
Adverse functional, metabolic, or structural changes in ischemic tissues resulting from the restoration of blood flow to the tissue (REPERFUSION), including swelling; HEMORRHAGE; NECROSIS; and damage from FREE RADICALS. The most common instance is MYOCARDIAL REPERFUSION INJURY.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.
Liquids transforming into solids by the removal of heat.
Preservation of cells, tissues, organs, or embryos by freezing. In histological preparations, cryopreservation or cryofixation is used to maintain the existing form, structure, and chemical composition of all the constituent elements of the specimens.
Death and putrefaction of tissue usually due to a loss of blood supply.
Four or five slender jointed digits in humans and primates, attached to each HAND.
An idiopathic vascular disorder characterized by bilateral Raynaud phenomenon, the abrupt onset of digital paleness or CYANOSIS in response to cold exposure or stress.
A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
Analog or digital communications device in which the user has a wireless connection from a telephone to a nearby transmitter. It is termed cellular because the service area is divided into multiple "cells." As the user moves from one cell area to another, the call is transferred to the local transmitter.
An instrument for reproducing sounds especially articulate speech at a distance. (Webster, 3rd ed)
An absence of warmth or heat or a temperature notably below an accustomed norm.
Selection of a type of occupation or profession.
A specialized barrier in the kidney, consisting of the fenestrated CAPILLARY ENDOTHELIUM; GLOMERULAR BASEMENT MEMBRANE; and glomerular epithelium (PODOCYTES). The barrier prevents the filtration of PLASMA PROTEINS.
Highly differentiated epithelial cells of the visceral layer of BOWMAN CAPSULE of the KIDNEY. They are composed of a cell body with major CELL SURFACE EXTENSIONS and secondary fingerlike extensions called pedicels. They enwrap the KIDNEY GLOMERULUS capillaries with their cell surface extensions forming a filtration structure. The pedicels of neighboring podocytes interdigitate with each other leaving between them filtration slits that are bridged by an extracellular structure impermeable to large macromolecules called the slit diaphragm, and provide the last barrier to protein loss in the KIDNEY.
The layer of EXTRACELLULAR MATRIX that lies between the ENDOTHELIUM of the glomerular capillaries and the PODOCYTES of the inner or visceral layer of the BOWMAN CAPSULE. It is the product of these two cell types. It acts as a physical barrier and an ion-selective filter.
A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The protein complement of an organism coded for by its genome.
The systematic study of the complete complement of proteins (PROTEOME) of organisms.
A group of antigens consisting principally of Jk(a) and Jk(b), determined by allelic genes. Amorphs are encountered. Antibodies of these substances are usually weak and quite labile, stimulated by erythrocytes.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.

Calcium channel blocker and renal mitochondrial function in warm renal ischemia. (1/125)

OBJECTIVE: Ions, particularly calcium ions, play an important role in ischemia-reperfusion cell injury. In this study, we investigated the action of verapamil on the mitochondrial function of kidneys submitted to ischemia without blood reperfusion in order to study isolated early and late ischemic effects. MATERIALS AND METHODS: 44 rats were submitted to bilateral warm renal ischemia for 30 minutes. The kidneys were then immediately reperfused with saline or Euro-Collins (EC) solution, with and without previous administration of 0.35 mg/kg of verapamil. Mitochondrial function was assessed at the end of renal perfusion and after 24 hours of cold preservation. RESULTS: In kidneys perfused with saline, verapamil allowed a significant early preservation of state III mitochondrial respiration, a result that was no longer evident after 24 hours. In kidneys perfused with EC solution, verapamil did not change state III for either early or late evaluations. Comparison of the groups showed that the results obtained for kidneys perfused with EC were always superior to those obtained for the saline group, except for the initial analysis of kidneys treated with saline and verapamil, which showed results similar to those obtained with EC perfusion alone. CONCLUSION: Administration of verapamil before warm ischemia provides partial and short-lasting functional protection of the mitochondrial function in kidneys perfused with sodium rich saline. With Euro-Collins solution, verapamil did not show any additional beneficial effect. This fact permits us to conclude that protective action is effective only under conditions that facilitate increased sodium uptake and/or potassium loss.  (+info)

Major effects of delayed graft function and cold ischaemia time on renal allograft survival. (2/125)

BACKGROUND: There is mounting evidence from experimental and clinical studies that the quality of organs from cadaver donors may be influenced by events occurring around the time of brain death, and that these may affect transplant outcome. The aim of this study is to investigate the influence of donor factors on renal allograft outcome in a homogeneous cohort of 518 patients transplanted in a single centre over a 9 year period. METHODS: Endpoints of the study were delayed graft function (DGF), acute rejection (AR), 1 year graft survival and long-term survival of those grafts that reached 1 year. Multivariate analysis was performed to determine factors that may have influenced the graft outcome indicators. RESULTS: DGF was the major predictor of graft failure overall with cold ischaemia time (CIT) as an important independent factor. The level of histocompatibility did not influence graft survival. DGF was the major factor affecting 1 year graft survival (P<0.0005) with effects persisting beyond 1 year. DGF was significantly influenced by CIT, donor age, female kidney into male recipient and donor creatinine (P<0.05). Other donor factors and factors associated with donor management were not risk factors for DGF, rejection episodes or graft survival. The risk factors for a number of AR episodes were HLA-DR mismatch and DGF (P<0.005). When grafts surviving for 1 year were considered, only CIT, recipient age and creatinine at 1 year (P<0.05) were found to affect graft survival significantly. CONCLUSIONS: The results of this analysis of well-matched transplant recipients show that CIT and DGF are the most important predictors of poor short and long-term graft survival. Therefore, in order to improve the long-term survival of renal allografts efforts should focus on limiting CIT and the damage that occurs during this period and on improving our understanding of DGF.  (+info)

Glycine intravenous donor preconditioning is superior to glycine supplementation to low-potassium dextran flush preservation and improves graft function in a large animal lung transplantation model after 24 hours of cold ischemia. (3/125)

OBJECTIVES: The potential role of glycine in combination with standard lung preservation with low-potassium dextran solution in lung ischemia-reperfusion injury has not been investigated in a preclinical porcine transplant model. METHODS: In a control group (n = 6), donor lungs were flushed with 1 liter of low-potassium dextran solution. In a second group (LPD-glyc, n = 6), low-potassium dextran solution was supplemented with 3.75 g of glycine. In a third group (IV-glyc, n = 6), donor preconditioning was performed by intravenous administration of 3.75 g glycine 1 hour before low-potassium dextran preservation. Grafts were stored in low-potassium dextran at 4 degrees C for 24 hours. Posttransplant graft function was assessed throughout a 7-hour observation period. RESULTS: In the control group, 2 recipients died of right-sided heart failure caused by severe ischemia-reperfusion injury. All animals of the glycine groups survived the entire observation period. Pulmonary vascular resistance remained significantly (P < .01) lower in both glycine groups when compared with controls. At the end of the observation period pulmonary vascular resistance in the control group was higher (P < .01) compared with the glycine groups (1310 +/- 319 dyn x sec x cm(-5) vs 879 +/- 127 dyn x sec x cm(-5) [LPD-glyc] vs 663 +/- 191 dyn x sec x cm(-5) [IV-glyc]). Changes of lung tissue water content were lower in the IV-glyc group compared with the LPD-control (P < .01) and LPD-glyc lungs (P < .05). Oxygenation (PO2/FiO2) was higher in the IV-glyc group compared with the LPD-glyc and control lungs (445 +/- 110 mm Hg vs 388 +/- 124 mm Hg [P < .01] vs 341 +/- 224 mm Hg [P < .001], respectively). DISCUSSION: Modification of low-potassium dextran solution with glycine or donor preconditioning ameliorates ischemia-reperfusion injury in lung transplantation. This intriguing approach merits further evaluation with respect to the mechanisms involved and may improve results in clinical lung preservation.  (+info)

In situ demonstration of improvement of liver mitochondria function by melatonin after cold ischemia. (4/125)

In a previous investigation, reperfusion with a melatonin-containing medium was demonstrated to enhance bile production and tissue ATP levels in rat livers, cold-preserved with University of Wisconsin (UW) or Celsior solutions, with respect to melatonin-free reperfusion; lipid peroxidation products in the perfusate were not influenced by the indole. This was ascribed to an increased efficiency of the hepatocyte mitochondria induced by melatonin. Reactive oxygen species (ROS) normally leak from the electron transfer chain in mitochondria and excessive ROS production is presumed to mediate ischemia-reperfusion (I/R) damage. A histochemical reaction was used to demonstrate ROS on the same model. Compared to the lobular zonation of ROS in control livers, the stained area of cold-preserved livers reperfused without melatonin was restricted to a narrow portal region, in keeping with the much lower ATP content. When reperfusion was performed with melatonin, the liver morphology was improved and the ROS reaction in hepatocytes more intense, though not reaching the control liver pattern. Sinusoidal cells were poorly-stained in both cases. In conclusion, with this different approach, melatonin was confirmed to improve mitochondrial performance and to discriminate parenchymal from sinusoidal cell behavior. Our observations confirm that melatonin mitigates I/R injury and support its potential in liver transplantation.  (+info)

Cardioprotective effects of tetrahydrobiopterin in cold heart preservation after cardiac arrest. (5/125)

BACKGROUND: It has recently been shown that tetrahydrobiopterin (BH4), an essential cofactor of nitric oxide synthase (NOS), reduces ischemia-reperfusion myocardial injury. The aim of this study was to determine if supplementation with BH4 after cardiac arrest followed by cold heart preservation would exert a cardioprotective effect against ischemia-reperfusion injury. MATERIALS AND METHODS: Isolated perfused rat hearts were subjected to 4 degrees C cold ischemia and reperfusion. Hearts were treated with cold cardioplegic solution with or without BH4 just before ischemia and during the first 5 min of reperfusion period. Effects of BH4 on left ventricular function, myocardial contents of high-energy phosphates, and nitrite plus nitrate were measured in the perfusate, before ischemia and after reperfusion. Moreover, the effect of BH4 on the cold-heart preservation followed by normothermic (37 degrees C) ischemia was determined. RESULTS: BH4 improved the contractile and metabolic abnormalities in reperfused cold preserved hearts that were subjected to normothermic ischemia. Furthermore, BH4 significantly alleviated ischemic contracture during ischemia, and restored the diminished perfusate levels of nitrite plus nitrate after reperfusion. CONCLUSION: These results demonstrated that BH4 reduces ischemia-reperfusion injury in cold heart preservation. The cardioprotective effect of BH4 implies that BH4 could be a novel and effective therapeutic option in the preservation treatment of donor heart after cardiac arrest.  (+info)

Mediators of rat ischemic hepatic preconditioning after cold preservation identified by microarray analysis. (6/125)

Hepatic ischemia-reperfusion injury associated with liver transplantation is an as yet unresolved problem in clinical practice. Preconditioning protects the liver against the deleterious effects of ischemia, although the mechanism underlying this preconditioning is still unclear. To profile gene expression patterns involved in hepatic ischemic preconditioning, we analyzed the changes in gene expression in rat livers by DNA microarray analysis. Approximately 116 genes were found to have altered gene expression after 8 hours of cold ischemia. Moreover, the expression of 218 genes was modified by classic preconditioning followed by the same ischemia process. Given the importance of the effects of ischemic preconditioning (IP) in minimizing the liver damage induced by sustained ischemia before reperfusion, this study analyzed the putative genes involved in the beneficial role of IP in liver grafts undergoing cold ischemia before its implantation in the recipient (IP+I). Great differences were found in the gene expression pattern of ischemic preconditioning + long cold ischemia (IP+I) group when compared with the long cold ischemia alone condition (I), which could explain the protective regulatory mechanisms that take place after preconditioning. Twenty-six genes that were downregulated in cold ischemia were found upregulated after preconditioning preceding a long cold ischemia period. These would be genes activated or maintained by preconditioning. Heat shock protein genes and 3-hydroxy-3-methylglutaryl-coenzyme A reductase are among the most markedly induced transcripts.  (+info)

Prolonging warm ischemia reduces the cold preservation limits of liver grafts in swine. (7/125)

BACKGROUND: The critical shortage of transplantable organs necessitates utilization of unconventional donors. But the safe time limits of cold preservation of liver grafts subjected to warm ischemia (WI) for up to 30 minutes from non-heart-beating-donors (NHBDs) has not been delineated. In this study, we investigated how the limits of cold ischemia (CI) in University of Wisconsin (UW) solution are changed in liver grafts subjected to WI from 10 to 30 minutes. METHODS: A simple porcine NHBD liver transplantation (LT) model was developed. In donors, livers were subjected to 10, 20 or 30 minutes of WI and subsequent different times of CI in UW solution. Animals were divided into three groups (WI 10 min, WI 20 min, WI 30 min, n=13 in each group) and nine subgroups (from CI 6 h to CI 28 h). One-week survival rates of recipients, hepatic function, liver energy metabolism, grafted liver microcirculation and pathological observations of the liver were compared. RESULTS: In the WI 10 min group, the one-week survival rate of the CI 20 h subgroup was significantly higher than in the other two subgroups (CI 24 h and CI 28 h) (P<0.05). Furthermore, the CI 20 h subgroup had a lower level of alanine aminotransferase (ALT), less pathological damage, a higher concentration of adenosine triphosphate (ATP) and microcirculatory blood flow in the grafted livers at 1 hour after reperfusion than the other two subgroups. The same trends were also found in the other two groups (WI 20 min and WI 30 min) and their subgroups. CONCLUSIONS: The cold preservation limits of the liver grafts shortened from 20 to 12 to 6 hours when WI time was prolonged from 10 to 20 to 30 minutes. Only the liver grafts within these time limits could be safely transplanted.  (+info)

Novel short-term hypothermic oxygenated perfusion (HOPE) system prevents injury in rat liver graft from non-heart beating donor. (8/125)

OBJECTIVE: To assess a machine perfusion system in rescuing liver grafts from non-heart-beating donors (NHBD). SUMMARY BACKGROUND DATA: The introduction of extracorporeal liver perfusion systems in the clinical routine depends on feasibility. Conceivably, perfusion could be performed during recipient preparation. We investigated whether a novel rat liver machine perfusion applied after in situ ischemia and cold storage can rescue NHBD liver grafts. METHODS: We induced cardiac arrest in male Brown Norway rats by phrenotomy and ligation of the subcardial aorta. We studied 2 experimental groups: 45 minutes of warm in situ ischemia + 5 hours cold storage versus 45 minutes of warm in situ ischemia + 5 hours cold storage followed by 1 hour hypothermic oxygenated extracorporeal perfusion (HOPE). In both groups, livers were reperfused in a closed sanguineous isolated liver perfusion device for 3 hours at 37 degrees C. To test the benefit of HOPE on survival, we performed orthotopic liver transplantation in both experimental groups. RESULTS: After cold storage and reperfusion, NHBD livers showed necrosis of hepatocytes, increased release of AST, and decreased bile flow. HOPE improved NHBD livers significantly with a reduction of necrosis, less AST release, and increased bile flow. ATP was severely depleted in cold-stored NHBD livers but restored in livers treated by HOPE. After orthotopic liver transplantation, grafts treated by HOPE demonstrated a significant extension on animal survival. CONCLUSIONS: We demonstrate a beneficial effect of HOPE by preventing reperfusion injury in a clinically relevant NHBD model.  (+info)

TY - JOUR. T1 - Ex Vivo Transfer of Nuclear Factor-κB Decoy Ameliorates Hepatic Cold Ischemia/Reperfusion Injury. AU - Yoshizumi, Tomoharu. AU - Ikeda, Yasuhiro. AU - Kaneda, Y.. AU - Sueishi, K.. PY - 2009/6/1. Y1 - 2009/6/1. N2 - Cold ischemia/reperfusion injury of the hepatic graft has been attributed to the release of various inflammatory cytokines. Specific inhibition of these cytokines may improve viability of the hepatic graft upon reperfusion. Herein we have assessed the efficacy of cis element decoy against nuclear factor-κB binding site delivery to the hepatic tissue in a rodent liver transplantation model. At 8 hours after reperfusion of the liver, significant reduction was noted in the livers treated with decoy in the release of cytosolic enzymes from the hepatocytes and in serum tumor necrosis factor α (P , .05). The neutrophilic infiltration into the hepatic grafts was significantly suppressed in the livers treated with decoy oligodeoxynucleotides (ODNs). Decoy ODNs against ...
Looking for cold ischemia time? Find out information about cold ischemia time. sequential arrangement of all events, or the interval between two events in such a sequence. The concept of time may be discussed on several different... Explanation of cold ischemia time
TY - CONF. T1 - Gene Expression Profiling of Cold Ischemia/Reperfusion (I/R) Injury in Murine Cardiac Isografts. AU - Schneeberger, S.. AU - Mark, W.. AU - Brandacher, G.. AU - Obrist, Philipp. AU - Lackner, Peter. AU - Hernegger, G.. AU - Meusburger, H.. AU - Renz, O.. AU - Margreiter, R.. AU - Amberger, A. N1 - Supplement to Transplantation. August 27, 2002. Vol. 74, Nr. 4. PY - 2002. Y1 - 2002. M3 - Abstract. ER - ...
The effects of cold storage using Custodiol® (Histidine-Tryptophan-Ketoglutarate, HTK) or isotonic saline solution on mitochondrial function in hearts (left and rights ventricles) and various blood vessels of pigs were investigated. Hearts, saphenous veins, internal-mammary-arteries and aortas of male landrace pigs were harvested and exposed to cold ischemia in either saline or Custodiol-HTK solution. Mitochondrial function was measured in situ in permeabilized fibers by high-resolution respirometry. Mitochondrial respiratory capacities (maximal respiration rates) were similar in the right and left ventricle in controls and after 14 h of cold storage were significantly better preserved in Custodiol-HTK than in saline solution. Mitochondrial respiration rates in various blood vessels including aorta, arteries and veins were less than 5% of myocardium rates. In contrast to the pig heart, in some blood vessels, like veins, mitochondrial function remained stable even after 24 h of cold ischemia. HTK
Background: Deceased-donor (DD) kidneys are at higher risk for ischemia/reperfusion injury leading to increased inflammatory mediators and innate immune response. We aimed to investigate the effects of prolonged cold ischemia (CIT) on intragraft molecular gene expression profiles of DD kidneys comparing to living-donor (LD) pre-implantation biopsies and to investigate the molecular features of DD biopsies that develop delayed graft function (DGF).. Methods: There were 48 pre-implantation kidney biopsy samples (29 LD and 19 DD). The cold ischemia time (CIT) was , 16 hrs in 10 and , 16 hrs in 9 DD kidneys. 9 DD patients developed DGF after transplantation. The gene expression profiles were studied by Affymetrix HuGene 1.0 ST expression arrays.. Results: Ingenuity Pathways Analysis demonstrated that DD pre-implantation biopsies showed increased expression of pathways related to acute inflammatory response, lymphocyte mediated immunity, innate and humoral immune response, complement activation and ...
Definition of ischemia time in the Legal Dictionary - by Free online English dictionary and encyclopedia. What is ischemia time? Meaning of ischemia time as a legal term. What does ischemia time mean in law?
Ischemia and reperfusion are natural steps during kidney transplantation, and IRI is considered one of the most important nonspecific factors affecting allograft dysfunction. Transplanted organs experience several episodes of ischemia, in which cold ischemia occurs during allograft storage in preservation solutions. Even though cold ischemia has been studied extensively, all of the studies have been carried out in vitro and ex vivo models. There is no in vivo model available to examine renal IRI induced solely by cold ischemia. In the present study, we developed an in vivo mouse model to study renal IRI induced exclusively by cold ischemia through clamping the renal pedicle for 1 to 5 hours. During the ischemic phase, blood was flushed from the kidney with cold saline through a small opening on the renal vein. The kidney was kept cold in a kidney cup with circulating cooled saline, while the body temperature was maintained at 37℃ during the experiment. The level of kidney injury was evaluated by
Effect of cold ischemic times and time after transplantation on regional myocardial motion after heart transplantation. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Researchers have long considered the NCI supported Cooperative Human Tissue Network (CHTN) as a source for quality collection and preservation of tissue samples from remnant surgical tissue specimens. In an organized tissue procurement setting serving a large population of researchers, the trained procurement personnel, specialized reagents and monitoried frozen storage facilities assure the availability of quality research, monitored preservation techniques and temperature controlled shipping required for successful research support.. The CHTN Midwestern Division (MWD) has experienced an increase in investigator demand for fresh tissues over the past two years. Approximately 23% of the tissues distributed by the CHTN MWD is fresh tissue. Requests for frozen and formlin-fixed paraffin embedded tissues, however, remain constant and stable. The increased interest in fresh tissue likely reflects an increased focus on the study of vital cells in controlled environments for... Read more ...
While the method itself might be close to perfect, upstream (pre-analytic) and downstream (data mining) processes need to be improved.
nurul izzati abdullah zayawi ym:nurizz_fifa105 email:izzati[dot]abdullah[at]gmail[dot]com sek.keb.gong badak [93-99],smka tok jiring [00-04],darul quran jakim [jan05-aug05],cenFOS iium [dec05-sep06],faculty of medicine, mansoura university, egypt [present~] ask me anything here : http://formspring.me/ ...
Intestinal transplantation is associated with high rates of mortality and morbidity. This paper details our initial experience with 82 heterotopic small bowel transplants based upon the original rat model described by Monchik and Russell (Surgery 70:693-702, 1971). A key issue associated with mortality was a warm ischaemia time of more than 40 min (P | 0.01). Sixty- eight percent of the recipients (44/65) survived for mere than 24 hr when the warm ischaemia time of the donor bowel was reduced to less than 40 min. Investigators establishing an animal model of heterotopic small bowel transplantation should pay particular attention to the warm ischaemia time of the donor bowel.
Cold ischemia time (from flush to out-of-ice) and warm ischemia time (from out-of-ice to reperfusion) are known to impact delayed graft function (DGF) rates and long-term allograft survival following deceased donor kidney transplantation. We propose an additional ischemia time, extraction time, begi …
We previously reported that progression of liver cirrhosis is quicker and survival is dismal in patients with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection, especially when acquired in childhood through contaminated blood products. Recently, we performed the first deceased donor liver transplantation (DDLT) for an HIV/HCV-coinfected hemophilic patient in Japan. A 40-year-old man was referred to our hospital for liver transplantation. Regular DDLT was performed using the piggyback technique with a full-sized liver graft. Cold ischemia time was 465 min, and the graft liver weighed 1,590 g. The antiretroviral therapy (ART) was switched from darunavir/ritonavir to raltegravir before the transplant for flexible usage of calcineurin inhibitors postoperatively; tenofovir was used as the baseline treatment. The postoperative course was uneventful, and the patient was discharged home on day 43. He started receiving anti-HCV treatment on day 110 with pegylated interferon, ...
Results In the PI arm 11.1% (n=99) had AbMI versus 6.9% (n=59) in primary PCI arm (p,0.01). In a multivariable model, AbMI patients overall had less baseline ΣST-deviation, fewer baseline Q-waves and shorter total ischaemic times. PI AbMI patients had faster time to TNK (90 vs 100 min, p=0.015): total ischaemic time was 100 min longer in primary PCI AbMI patients and no difference in ischaemic time existed between AbMI and non-AbMI patients within this group. Although no significant interaction between treatment and AbMI on the composite endpoint of death/shock/congestive heart failure/recurrent MI occurred (p=0.292), PI AbMI patients had a lower incidence in this endpoint than non-AbMI patients (5.1 vs 12%, p=0.038); this was not evident in primary PCI patients. Forty-five patients (ie, 2.5%) had masquerading MI with minimal biomarker elevation and no evolution in baseline ST-elevation.. ...
Impact of performing multiple liver transplants (LT) in a short period of time is unknown. Consecutively performed LT potentially increase complication rates through team fatigue and overutilization of resources and increase ischemia time. We analyzed the impact of undertaking consecutive LT (Consecutive liver transplant, CLT; LT preceded by another transplant performed not more than 12 h before, both transplants grouped together) on outcomes. Of 1702 LT performed, 314 (18.4%) were CLT. Outcome data was compared with solitary LT (SLT; not more than one LT in 12-h period). Recipient, donor, and graft characteristics were evenly matched between SLT and CLT; second LT of CLT group utilized younger donors grafts with longer cold ischemic times (P = 0.015). Implantation and operative time were significantly lower in CLT recipients on intergroup analysis (P = 0.0001 and 0.002, respectively). Early hepatic artery thrombosis (E-HAT) was higher in CLT versus SLT (P = 0.038), despite absolute number of ...
Heart transplantation is the final treatment option in heart failure, and transplant patients have substantially increased survival rates and quality of life.27 The first human-to-human heart transplantation was performed in South Africa in 1967, and by the end of 1968 102 patients had received transplants at 52 institutions.1 However, the results were disappointing, with a 60% early death rate and a mean survival of only 29 days.28 In a large study in 2000, when the duration of cold ischaemia was 6 h, graft survival at 3 years after surgery was nearly 25% less than that when the cold ischaemia period was ,2 h.29. Use of organs from marginal donors has resulted in decreased graft function and survival compared with the use of organs from younger donors.30 It is currently difficult to obtain donor hearts. In addition, long-term outcomes for transplanted hearts are limited by the development of cardiac allograft vasculopathy resulting from immunological and non-immunological risk factors ...
Aim: To define regional patterns in post OLT LOS.. Methods: Using the UNOS database (06/2011) we reviewed data on 65,891 OLT recipients, 01/2000-12/2010. Patients excluded (n=11,784) were dual organ, and pediatric recipients, deaths ≤2 days, LOS,180 days or missing data. Variables were categorized (n=54,107): MELD score(≤10, 11-18,19-24, ≥25) Karnofsky score (0-30, 31-60, 61-100), cold ischemia time (CIT, hrs) (,6, 6-12, ,12≤20, ,20). Predictors of LOS were identified univariately, and multivariately using a linear regression model of Log2(LOS). Regional (R) differences in multivariate associations were assessed using parameters for interactions with region, and within regions. The LOS median ratio (MR) was used as a measure of relative change in median LOS.. Results: Mean LOS ranged from 13.3±14(Mean±SD) days in R6 to 19.5±20 days in R9. On multivariate analysis factors associated with ,10% increase LOS were: patient ventilated at OLT (LOS MR estimate 1.33, i.e. 33% increase in LOS), ...
Kraus FB, Ludwig-Kraus B (2018) Measuring zinc on the Roche cobas c502 analyzer-Validation, comparison, and pre-analytic aspects. J Clin Lab Anal Ludwig-Kraus B, Kraus FB (2017) Similar but not consistent: Revisiting the pitfalls of measuring IgG subclasses with different assays. J Clin Lab Anal Kraus FB, Mischereit M, Eller C, Ludwig-Kraus B (2016) Characterization and Validation of the LT-SYS Copper Assay on a Roche Cobas 8000 c502 Analyzer. Laboratory Medicine, lmw049. Bergner M, Seliger G, Schneider U, Stepan H, Kraus FB, Haase R, Wickenhauser C, Hoyer D, Schleussner E, Tchirikov M (2016) Multimodal Monitoring Fetal Inflammation at PPROM - the MuMfI-PPROM-Trial. Geburtshilfe Frauenheilkd. 76- P18. Salt AN, Hartsock JJ, Gill RM, King E, Kraus FB, Plontke SK (2016) Perilymph pharmacokinetics of locally-applied gentamicin in the guinea pig. Hearing Research 342, 101-111. Kapheim KM et al. (2015) Genomic signatures of evolutionary transitions from solitary to group living. Science 348, 1139-1143. ...
Histological Analysis At euthanization, renal tissue specimens were fixed Animal weights did not differ between the groups in neutral 10% buffered formalin and embedded in (MP25, 23.5 ± 4.6 kg; MP30, 26.3 ± 3.2 kg; p = paraffin. Tissue injury was assessed on periodic acid- 0.201). All animals demonstrated normal renal func- Schiff (PAS) stained 4 lm-thick sections by scoring tion before the start of the experiments (serum creati- glomerular damage (shrinking), tubular damage, infil- nine; MP25, 1.09 ± 0.14 mg/dL; MP30, 1.13 ± 0.10 tration of inflammatory cells, interstitial edema and mg/dL; p = 0.565). Cold ischemic times (CITs) necrosis. Tubular damage was defined as dilatation, of the groups were comparable (CIT, MP25, 20:32 h ± denudation of the tubular basement membrane and 0:06; MP30, 20:28 h ± 0:17; p = 0.158). Also, times vacuolization. Injury of each specimen was graded to required for both anastomoses were comparable the extent of region involvement in 10 randomly cho- between the ...
Citáty Ben Bernanke. Přehled nejoblíbenějších a nejznámějších citátů. Ben Shalom Bernanke je americký ekonom, bývalý předseda rady guvernérů Federál…
During the day, I get hot unexpectedly. I didnt care for the cold to begin with but now being in a room thats too cool will bother me. At night, it just gets weird. Ill be hot then cold, then hot, then cold. I have had the fan on and the covers over me within a minute of each other - and more than once a night! So, is this like normal? :huh:
24 yrs old Male asked about Cold from 2 weeks, 1 doctor answered this and 91 people found it useful. Get your query answered 24*7 only on | Practo Consult
Background. In renal transplantation, cold ischaemia (CI) determines acute rejection through innate immunity among others. Acute rejection episodes are a risk factor for late allograft dysfunction and proteinuria. This implies some alteration of the glomerular filtration barrier (GFB). Besides its effects on acute rejection, we hypothesized that CI might somehow damage the GFB being directly responsible for late proteinuria.. Methods. On rat kidney allografts suffering from antibody-mediated acute rejection with or without CI and compared with syngeneic grafts, we quantified the gene expression of innate and adaptive immune mediators and assessed the capillary glomerular basement membranes (CapBM) by immunostaining collagen-IV (ColIV). ColIV was also assessed in equivalent groups from a previous chronic study followed up for 24 weeks.. Results. CI up-regulated enzymes critical in the stabilization of collagen chains, increasing ColIV deposition and thickening the CapBM. CI increased the C4d and ...
Adhesion molecules play a crucial role in transplant rejection in regulating the interaction of inflammatory cells with cells in the vascular wall. In an aortic transplantation model, we have previously analysed the early adhesion process (7.5 min to 24 h) and the impact of cold ischaemia time (1-24 h) upon transplant arteriosclerosis during the first 2 months after transplantation in the rat. The aim of this investigation was to study adhesion molecules in accelerated transplant arteriosclerosis in a rat model by analysing the immunohistochemical expression of CD11b and ICAM-1 up to 2 months and followed by a semiquantitative evaluation and multivariant analysis. Antigen expression of CD11b and ICAM-1 adhesion molecules was stronger in the aortic allografts than in the ischaemia-induced syngeneic aortic grafts in the whole vessel wall. Neither ICAM-1 nor CD11b antigen expression correlated significantly with time periods of ischaemia/reperfusion injury in allogeneic or syngeneic aortic ...
The major extended donor criteria (maEDC; steatosis |40%, age |65 years, and cold ischemia time |14 h) influence graft and patient outcomes after liver transplantation. Despite organ shortages, maEDC organs are often considered unsuitable for transplantation. We investigated the outcomes of …
Date: 19 Mar 96 00:18:15 EST From: Mike Darwin ,. , Subject: BPI TECH BRIEF #18 Cryopreservation of CryoCare Patient #C-2150 by Mike Darwin Introduction On December 12th, 1995 James Gallagher, a 55-year-old software developer from Sunset Beach, California, became CryoCares first member to enter cryopreservation. He also became the first patient ever to benefit from new technologies developed to reduce three forms of injury: * pre-mortem shock * warm ischemia (the time interval between pronouncement of death and restoration of adequate blood circulation) * cold ischemia experienced during initial blood washout and cooling, and also during iced-transport from the location where legal death occurred to the facility where cryoprotective perfusion is carried out. The following is not quite a full technical report, but neither is it simply a lay-level of summary of key events without reference to the technical details and the impact those details had upon this patients care and potentially, future ...
Chill out with our top seven low-potassium fruit salads for a kidney diet. It may be hot outside, but you can keep cool with recipes such as Caramel Apple Salad or Festive Fruit Salad.
Whole grains are high in protein and potassium, with the exception of oatmeal. Processed grains in products such as pasta, bread, bagels and cereal are lower in potassium and suitable for a low-potassium diet. Avoid processed foods that have trans fats, such as crackers and cookies.. ...
This report features 7 companies, including Dr. Franz Köhler Chemie GmbH (Germany), Lifeline Scientific, Inc. (USA), Essential Pharmaceuticals, LLC (USA), Preservation Solutions, Inc. (USA)
TY - GEN. T1 - Rapid chilling of carcasses using vascular perfusion. AU - Brown, T. AU - Richardson, I. AU - Swain, MVL. AU - Evans, JA. N1 - Name and Venue of Event: Naples, Italy, 24-26 September 2007. PY - 2007. Y1 - 2007. M3 - Conference Contribution (Conference Proceeding) BT - Proceeding of the 3rd CIGR Section VI International Symposium on Food and Agricultural Products : Processing and Innovations. ER - ...
How is Long-Lasting Delayed Graft Function abbreviated? LLDGF stands for Long-Lasting Delayed Graft Function. LLDGF is defined as Long-Lasting Delayed Graft Function very rarely.
Description, comparison with clinical data and clinical exploitation of a non-invasive and relatively inexpensive method for screening cardiovascular systems based on multi-parameter analysis of heart haemodynamics and vascular perfusion in selected areas of the body ...
Read 9 responses to: I have a 8 month old baby and she has had a cold for... Find the best answer on Mamapedia - mom trusted since 2006.
TY - JOUR. T1 - Glutathione supplementation to University of Wisconsin solution causes endothelial dysfunction. AU - Tambyraja, A L. AU - Mitchell, R. AU - Driscoll, P J. AU - Deans, C. AU - Parks, R W. AU - Rahman, I. AU - Megson, I L. PY - 2007. Y1 - 2007. N2 - Glutathione (GSH) is added to University of Wisconsin (UW) organ preservation solution to protect against oxidative stress. This study assesses the effect of GSH-supplementation on endothelial function in tissues subjected to cold ischaemia and compares its effects to a mono-ethyl ester equivalent (GSH-MEE) and S-nitrosated GSH (GSNO).. AB - Glutathione (GSH) is added to University of Wisconsin (UW) organ preservation solution to protect against oxidative stress. This study assesses the effect of GSH-supplementation on endothelial function in tissues subjected to cold ischaemia and compares its effects to a mono-ethyl ester equivalent (GSH-MEE) and S-nitrosated GSH (GSNO).. U2 - 10.1016/j.trim.2007.06.002. DO - ...
Ischemia-reperfusion (I/R) associated with hepatic resection and living related liver transplantation is an unsolved problem in clinical practice. Indeed, I/R induces damage and regenerative failure in clinical liver surgery. Signaling pathways regarding the pathophysiology of liver I/R and regeneration making clear distinction between situations of cold and warm ischemia, as well as liver regeneration with or without vascular occlusion, will be addressed. The different experimental models used to date to improve the postoperative outcomes in clinical liver surgery will be also described. Furthermore, the most updated therapeutic strategies, as well as the clinical and scientific controversies in the field, will be discussed. Such information may be useful to guide the design of better experimental models as well as the effective therapeutic strategies in liver surgery that can succeed in achieving its clinical application.
University of Maryland School of Medicine Background: A full facial procurement should allow concurrent procurement of all solid organs and ensure their integrity. Procurement of facial vascularized composite allografts (VCA) challenges the surgical teams with complex defects potentially requiring far greater time than solid organ procurement. Simultaneous-start procurement in these cases could entail cold ischemia times over 12 hours, risking post-reperfusion bleeding and reperfusion injury.. Methods: A VCA including all facial skin, mimetic muscles, multiple sensory and motor nerve branches, anterior tongue, and maxillary and mandibular segments was procured from a brain dead donor. Solid organ recovery included heart, lungs, liver, kidneys, and pancreas. Bedside tracheostomy and facial mask impression were performed the day before procurement.. Results: Facial VCA dissection time was 12 hours, spaced over a 15 hour period to diminish ischemia while the recipient was being prepared (Fig 1). ...
The incidence of primary graft dysfunction (PDF) after LT is approximately 25% within a range of 9.3 to 43.7% based on different definitions characterizing PDF [1-5]. Initial non-function (INF) develops in up to 6% of all considered cases and requires urgent retransplantation [6].. Risk factors are prolonged cold ischemia time or higher degree of graft steatosis and subsequent development of severe hepatic ischemia/reperfusion injury (IRI) [5, 7]. A cascade of cellular events results in microcirculatory flow disturbance. This may be distinguished as no-flow indicating capillary perfusion failure on the one hand, or reflow-paradox including activation of the leukocyte-endothelium interaction, release of toxic mediators, and impairment of the endothelial barrier on the other hand [8, 9]. There are, obviously, further different factors all contributing to an insufficient function of liver grafts and its detrimental effects on the overall outcome after LT: recipients condition, the donor data, ...
TY - JOUR. T1 - Az ischaemiás posztkondicionálás hatása az oxidatív stresszre és a szöveti struktúrára vékonybél meleg ischaemiás és autotranszplantációs modellekben.. AU - Nedvig, Klára. AU - Völgyi, Edina. AU - Wéber, G.. AU - Rőth, E.. AU - Ferencz, A.. PY - 2011/12. Y1 - 2011/12. N2 - Our study investigated the effect of ischemic postconditioning (IPO) in intestinal warm ischemia/reperfusion (I/R) and autotransplantation models. Warm ischemia was performed by occlusion of superior mesenteric artery for 1, 3 and 6 hours in white domestic pigs (n = 15). Prior to 3 hours reperfusion the intestine was postconditioned by 3 cycles of 30-seconds ischemia and 30-seconds reperfusion (IPO protocol). In the cold ischemia group (n = 15) the bowel was preserved in University of Wisconsin solution for 1, 3, and 6 hours. Prior to 3 hours reperfusion IPO protocol was applied, too. Tissue samples were collected after laparotomy (control) and at the end of the reperfusion periods. As far as ...
Donation after cardiac death (DCD) donors are vital to maximize the organ donor pool. Reperfusion injury (RI) is an important sequela in DCD organs due to warm and cold ischemia. RI manifests clinically as a high incidence of delayed graft function (DGF) and primary non-function (PNF) compared with donation after brain death organs. The importance of nitric oxide (NO) in the generation of reperfusion injury is pivotal ...
Strontium ranelate u common adverse effects of the body and tail, and sometimes leading to copper de ciency leads to a ii (olig4, nkx2.1, nkx2.1) and class ii and pluripotent stem cells (adscs) as a second- her physician makes a toenail thick and thin septa, characteristic of primitive cells. Have served to derive of human anatomy, ed 4, plate 332.) where gases, nutrients, and metabolic support, appropriate anti- microbial drugs. Clarifying stem-cell therapy s benefits and limitations of peptides as drugs. J urol 2005; be achieved by a simple, minimally invasive approaches with cold ischemia has been demonstrated in both groups. 5.1). Behaviour. Continuously with fragmenta- tion except for two years before moving to live longer: Causa- tion of the back. This port placement for urologic surgery tobias simpfend rfer, gencay hatiboglu, boris hadaschik, michael m ller, hans-peter meinzer, jens j. Rassweiler abstract despite continual improvements in treatment of advanced breast adverse effects ...
The research report titled Global Organ Preservation Solutions Market Professional Survey Report 2017 market size and forecast and overview on current market trends
I have a cold storage room underneath my front porch. It is poured out of concrete. It is around 20 long wide by 5 feet Wide. We dont use it at all for cold storage, but want to use it for regular storage year round. Obviously it is very cold in there during the winter.
Magnetic Particle Imaging of the vasculature to assess blood delivery and tissue level perfusion. The direct quantitation of nanoparticle tracers enables accurate perfusion measurements without confounding background tissue signal. Long circulating tracers persist within the vasculature for days, enabling repeated measurements for longitudinal studies. This enables truly functional imaging to measure changes in blood flow and tracer delivery over time in stroke and tumor models. ...
How to Stop a Cold when You Feel It Coming On. Prevention is the best defense against a cold, but sometimes, despite your best efforts, you still get sick. That is because the cold virus can live up to 18 hours on unwashed surfaces while...
Colds and Flu - Dos & Donts There are beneficial procedures for treating colds and flu that are easily overlooked. Meanwhile, a lot of commonly
Cold and flu can be extremely contagious and are usually more common at certain parts of the year. Learn about cold and flu prevention and treatment.
Whether you have a cold or the flu, our helpful guide will give you tips on how to fight the symptoms. Learn how to get better sooner.
People think the perfect day for running has bluebird skies and a slight breeze. But cold, rainy runs are key to unlocking potential and mental grit.
Read 9 responses to: Has anyone had a severe cold while being pregnant? ..... Find the best answer on Mamapedia - mom trusted since 2006.
Just wondering if anyone else gets cold while on this diet? I have been sole sourcing for approx 6 weeks and my hands are freezing! This isnt the...
Studies on cold-ischemia/eperfusion indicate an ischemic tolerance of more than 24 hours. The recipient has to look at ...
Furthermore, irreversible intestinal damage is seen after approximately only 5 hours of cold ischemia in the form of mucosal ... mesenteric ischemia, motility disorder, omphalocele/gastroschisis, tumors, and volvulus. Regardless of the underlying condition ... and serum pH and lactate levels measured for evidence of intestinal ischemia. The patient's immune system is strongly modulated ... extensive venous thrombosis or arterial ischemia of the mesentery, and motility syndromes. Donated intestines, like all organs ...
... cold ischemia MeSH E05.760.833.660 - organ preservation MeSH E05.760.833.890 - semen preservation MeSH E05.799.638.231 - body ...
More specifically, urinary endothelin-1 levels are used as an acute marker in cold ischemic reperfusion and injury. NGAL- ... Kidney ischemia can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the ... Kidney ischemia is a disease with a high morbidity and mortality rate. Blood vessels shrink and undergo apoptosis which results ... Moreover, renal ischemia can cause the delay of graft function after renal transplant and can cause rejection of the transplant ...
Areas of infarct or ischemic tissue will remain "cold". Pre- and post-stress thallium may indicate areas that will benefit from ... This produces coronary steal from areas of ischemia where arteries are already maximally dilated. ...
Acute localized ischemia of these structures also may be an important cause. Especially in children, vestibular neuritis may be ... Some people will report having an upper respiratory infection (common cold) or flu prior to the onset of the symptoms of ... 30% of affected people had a common cold prior to developing the disease. Either bacterial or viral labyrinthitis can cause a ... preceded by symptoms of a common cold. However, the causative mechanism remains uncertain. This can also be brought on by ...
Symptoms of acute limb ischaemia include: Pain Pallor Paresthesias Perishingly cold Pulselessness Paralysis These symptoms are ... Renal ischemia (nephric ischemia) Mesenteric ischemia Cerebral ischemia Cardiac ischemia In order to treat acute limb ischaemia ... Acute limb ischaemia (ALI) occurs when there is a sudden lack of blood flow to a limb. Acute limb ischaemia is caused by ... The New Latin term ischaemia as written, is a British version of the word ischemia, and stems from the Greek terms ischein 'to ...
In individuals with severe PAD, complications may arise, including critical limb ischemia and gangrene. Critical limb ischemia ... This can lead to pain at rest, feeling of cold, or numbness in the affected foot and toes. Other complications of severe PAD ... 2016), "Critical limb ischemia: current trends and future directions", J Am Heart Assoc, 5 (2): e002938, doi:10.1161/JAHA. ... Wounds are graded 0 through 3 on the presence of ulceration and/or gangrene and ischemia. Grade 0: no ulcer, no gangrene Grade ...
Late onset of pain (hours after injury) could be due to muscle ischaemia (reduced oxygen supply). This can lead to loss of ... Clinical parameters such as temperature of the limb extremities (warm or cold), capillary refilling time, oxygen saturation of ... indicating limb ischaemia), neurological deficits (paresthesia, tingling, numbness), and additional signs of poor perfusion ( ... the patient could still be observed until additional signs of ischaemia develops which warrants a surgical exploration. ...
Ischemia tolerance:: in order for cells and organs to survive without circulation of the blood, good antioxidant defenses and ... Yaish, M. W.; Doxey, A. C.; McConkey, B. J.; Moffatt, B. A.; Griffith, M. (2006). "Cold-active winter rye glucanases with ice- ... The process of freezing tolerance through cold acclimation is a two-stage mechanism: The first stage occurs at relatively high ... Freezing tolerance is enhanced as a gradual adaptation to low temperature through a process known as cold acclimation, which ...
If the condition progresses, the infant may turn pale, feel cold in the lower half of the body, and have a weak pulse due to ... Signs of ischemia due to interrupted aortic arch can be separated by the organ system involved: Liver injury: elevated serum ...
Ischaemia would then result in the decrease in oxygen supply to the heart, hence weaken the heart. It causes a vicious cycle as ... For instance, patients may have pale skin, cold hands and feet, and numb fingertips. These are mainly due to the reduction in ... The pathology of Raynaud's disease starts with the activation of sympathetic nervous system triggered by cold or the feeling of ... For instance, due to atherosclerosis, the plaque would obstruct and causes ischaemia - the reduction of blood flow through the ...
Presence of distal extremity ischemia (indicated by claudication, pain at rest, ischemic ulcers or gangrene) documented by ... The impaired circulation increases sensitivity to cold. Peripheral pulses are diminished or absent. There are color changes in ...
Buildup of white blood cells in small blood vessels may also plug the vessels, further contributing to ischemia. This blockage ... cold, shiny and hairless. Both venous and arterial ulcers may be painful, however arterial ulcers tend to be more painful, ...
Ischemia[edit]. Main article: Ischemia. Ischemia, meaning insufficient blood flow to a tissue, can also result in hypoxia. This ... If tissue is not being perfused properly, it may feel cold and appear pale; if severe, hypoxia can result in cyanosis, a blue ...
Hardison RC (Dec 2012). "Evolution of Hemoglobin and Its Genes". Cold Spring Harb Perspect Med. 2 (12): a011627. doi:10.1101/ ... Ischemia-reperfusion injury of the appendicular musculoskeletal system. ReferencesEdit. *^ a b c GRCh38: Ensembl release 89: ...
Otitis media often occurs with or following cold symptoms. The diagnosis is made by the combination of symptoms and examination ... GERD Myocardial ischemia (inadequate oxygen supply to the heart muscle) Conditions causing irritation of cervical nerves C2-C3 ...
Usage of a tight, non-elastic bandage will result in reduction of adequate blood flow, potentially causing ischemia. The fit ... "RICE" - Rest, Immobilize, Cold, Elevate[10]. *"HI-RICE" - Hydration, Ibuprofen, Rest, Ice, Compression, and Elevation ... To prevent localised ischemia or frostbite to the skin, it is recommended that the ice be placed within a towel or other ...
These episodes may be far more frequent than expected, cause myocardial ischemia (i.e. insufficient blood flow to portions of ... In addition, hyperventilation and virtually any stressful emotional or physical (e.g. cold exposure) event that is suspected of ... Ahmed B, Creager MA (April 2017). "Alternative causes of myocardial ischemia in women: An update on spontaneous coronary artery ... unnecessary exposure to cold, and early morning exertion. And, they should avoid any of the recreational and therapeutic drugs ...
Cold temperatures may also be a risk factor. The diagnosis should usually be made based on the presenting symptoms, but ... However, imaging should not delay surgical intervention as complications develop with prolonged ischemia. Immediate surgery is ... There is controversy whether cold weather months are associated with an increased risk. Testicular torsion occurs when there is ...
The use of cold for pain relief and as an anti-inflammatory has been known since the time of Hippocrates (460-377 B.C).[11] ... coagulation of blood thereby interrupting bloodflow to the tissue in turn causing ischemia and cell death; and ... Cold temperatures are used in cryoablation to chill or freeze cells that conduct abnormal heart rhythms. The catheter removes ... Cryoablation is a process that uses extreme cold to destroy tissue. Cryoablation is performed using hollow needles (cryoprobes ...
If the allergen is encountered and the symptoms are mild, a cold compress or artificial tears can be used to provide relief. ... Selectin antagonists have been examined in preclinical studies, including cutaneous inflammation, allergy and ischemia- ... Nonspecific measures to ameliorate symptoms include cold compresses, eyewashes with tear substitutes, and avoidance of ...
... cold feeling, warmth, pain, or burning) Dysgeusia (unpleasant taste in mouth) Feeling hot Dizziness Rash Erythema (reddening of ... and presence of focal cerebral ischemia. Gadobutrol should be administered intravenously by medical professionals only. Sterile ...
The pain is usually associated with swallowing of hot or cold water. Esophageal rupture: Those affected usually complain of ... such as Levine's sign in cardiac ischemia. However, in the case of acute coronary syndrome, a third heart sound, diaphoresis, ...
Cerebral ischemia is a frequently disputed possible cause, at least for some segment of the TGA population, and until the 1990s ... The most commonly cited precipitating events include vigorous exercise (including sexual intercourse), swimming in cold water ... One current hypothesis is that TGA may be due to venous congestion of the brain, leading to ischemia of structures involved ...
... cold) Provocative factors: is there anything that makes it worse? (rest, activity, etc.) SOCRATES: Site Onset Character ... Ischemia Atrial enlargement Lone or idiopathic Fever, anemia, high-output states Infarct Bad valves (mitral stenosis) ... Drugs/depression Elderly Multi-infarct/medication Environmental Nutritional Toxins Ischemia Alcohol "Ataxic GAAit" Guanine ...
The most common mechanism of damage is ischemia causing infarction and scar formation. After myocardial infarction, dead ... and patients will manifest with cold and clammy extremities, cyanosis, claudication, generalized weakness, dizziness, and ... Echocardiography can also help determine if acute myocardial ischemia is the precipitating cause, and may manifest as regional ...
"Cold Spring Harb. Perspect. Med. 3 (3): a011858. doi:10.1101/cshperspect.a011858. PMC 3579210. PMID 23388674.. ... Liepzig: Ischemia Verlagsgesellschaft.. *^ Puustinen A, Wikström M. (1991). "The heme groups of cytochrome o from Escherichia ...
Cell signaling during cold, drought, and salt stress. Plant Cell 14:S165-S183. Zhu JK. 2003. Regulation of ion homeostasis ... "Rapamycin protection of livers from ischemia and reperfusion injury is dependent on both autophagy induction and mammalian ... They also identified several regulatory factors for plant cold stress response. In addition, they discovered a number of plant ... Genetic analysis of osmotic and cold stress signal transduction in Arabidopsis thaliana: Interactions and convergence of ...
The most common trigger is cold, with 75% of people with hypersensitivity reporting pain upon application of a cold stimulus. ... will irreversibly progress to pulpal necrosis due to compression of the venous microcirculation and tissue ischemia, and ... Hot or cold food or drinks, and physical pressure are typical triggers in those individuals with teeth sensitivity. Movement of ... The scale of symptoms for DH are so variant, some patients are unable to eat ice cream or drink cold water, whereas for others ...
... also has neuroprotective properties in its demonstrated anti-hypoxia or anti-ischemia effects; there is a ... Hot flushes/cold sensation. *Photopsia. *Dyspnoea. *Visual disturbances. *Increased hepatic enzymes without associated clinical ...
It is classically associated with early-stage peripheral artery disease, and can progress to critical limb ischemia unless ... Perishing cold. *Pain. *Paraesthesia. *Paralysis. Causes[edit]. Most commonly, intermittent (or vascular or arterial) ...
... and also reduced severity of colds.[7] A subset of trials reported that supplementation reduced the incidence of colds by half ... "Liposomal-encapsulated Ascorbic Acid: Influence on Vitamin C Bioavailability and Capacity to Protect Against Ischemia- ... the Common Cold". California and Western Medicine. 62 (6): 309-10. PMC 1781017. PMID 18747053.. ... Pauling L (1970). Vitamin C and the Common Cold (1 ed.). San Francisco: W. H. Freeman. ISBN 9780716701590. . Retrieved August ...
Ischemia. *Brain ischemia. *Ischaemic heart disease. *large intestine: Ischemic colitis. *small intestine: Mesenteric ischemia ... Cold intolerance. Acrocyanosis. Erythrocyanosis crurum. Radiation. Radiation poisoning. Radiation burn. Chronic radiation ...
Such features include secondary hypothyroidism with tiredness, intolerance to cold, constipation, weight gain, hair loss and ... and are therefore most likely to be affected by ischemia), all the patients had growth hormone deficiency. Hormonal assay : ...
Any cause of inflammation such as common cold, influenza, and bacterial infections may cause transient vertigo if it involves ... and vasospasm of the blood vessels supplying the labyrinth or central vestibular pathways resulting in ischemia to these ...
New York: Cold Spring Harbor Laboratory Press. ISBN 978-0-87969-888-1. D. Bowen, Ivor (1993). Cell Biology International 17. ... "Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia". ... New York: Cold Spring Harbor Laboratory Press. ISBN 978-0-87969-887-4. Kierszenbaum, Abraham (2012). Histology and Cell Biology ...
Lower than 8 mg pills are still available Otc for sinus, head colds and flu, but is completely illegal in over the counter ... Schier JG, Traub SJ, Hoffman RS, Nelson LS (2003). "Ephedrine-induced cardiac ischemia: exposure confirmed with a serum level ... colds, allergies, other disease, or traditional Asian use.[46] On April 14, 2005, the U.S. District Court for the District of ...
An acute disease is a short-lived disease, like the common cold.. Chronic disease. A chronic disease is one that lasts for a ... Included in this category are contagious diseases-an infection, such as influenza or the common cold, that commonly spreads ... For example, a common cold is a primary disease, where rhinitis is a possible secondary disease, or sequela. A doctor must ... Ischemia. *Inflammation. *Cell damage. *Wound healing. Cellular adaptation. Atrophy. Hypertrophy. Hyperplasia. Dysplasia. ...
Excessive urination and extreme thirst and increased fluid intake (especially for cold water and sometimes ice or ice water) ...
Cold Spring Harb. Symp. Quant. Biol. 73: 403-10. doi:10.1101/sqb.2008.73.018. PMID 19022746.. ... "Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats". Stroke. 32 (4 ...
... and extreme hot or cold temperatures can affect a worker's ability to judge force and strength, which can lead to development ... Ischemia-repurfusion injuries of the appendicular musculoskeletal system. ReferencesEdit. *^ "CDC - NIOSH Program Portfolio : ...
This link is "dead cold" - archive.is, WayBack, WebCite, etc.) *^ "La ONT estima en 94.500 los transplantes de órganos solidos ... but failed due to Ischemia. Joseph Murray and J. Hartwell Harrison performed the first successful transplant, a kidney ...
... and cold intolerance. 75% develop a deficiency to gonadotropins (LH and FSH), which control the reproductive hormone glands. ...
Cohen S.; Doyle W. J.; Skoner D. P.; Rabin B. S.; Gwaltney Jr J. M. (1997). "Social ties and susceptibility to the common cold ... prolonged vasoconstriction results in ischemia which in turn leads to cell necrosis), as the body's immune system becomes ... Stress can make the individual more susceptible to physical illnesses like the common cold.[11] Stressful events, such as job ...
... and cold water immersion.[1] If more than two such beats are seen, then the condition is termed junctional rhythm. On the ... Active ischemia. *Angina pectoris *Prinzmetal's angina. *Stable angina. *Acute coronary syndrome *Myocardial infarction ...
Ischaemia *Avascular necrosis. *Osteonecrosis of the jaw. *Algoneurodystrophy. *Hypertrophic pulmonary osteoarthropathy. * ...
There is no official or formal dividing line between hypoperfusion and ischemia; sometimes the latter term refers to zero ... Poor perfusion (malperfusion), that is, ischemia, causes health problems, as seen in cardiovascular disease, including coronary ... Cold shock response. *Dead space (physiology). *Decompression (diving). *Decompression theory. *Diving reflex ...
"New Orleans filmmaker cleared in cold-case murder; false positive highlights limitations of familial DNA searching". The New ... Variable degrees of hemolysis and intermittent episodes of vascular occlusion resulting in tissue ischemia and acute and ...
Algra A; Halkes, PH; Van Gijn, J [et al] «Medium intensity oral anticoagulants versus aspirin after cerebral ischaemia of ... Stroke associated with sympathomimetics contained in over-the-counter cough and cold drugs». Stroke, 34, 7, 2003, pàg. 1667-72 ... Aspirin plus dipyridamole versus aspirin alone after cerebral ischaemia of arterial origin (ESPRIT): randomised controlled ...
common cold). Head. sinuses. Sinusitis. nose. Rhinitis Vasomotor rhinitis. Atrophic rhinitis. Hay fever. Nasal polyp. ... Ischemia. *Brain ischemia. *Ischaemic heart disease. *large intestine: Ischemic colitis. *small intestine: Mesenteric ischemia ...
... and individuals who immigrate from warm climates to cold climates, especially women who wear traditional veils or dresses that ... Ischaemia *Avascular necrosis. *Osteonecrosis of the jaw. *Algoneurodystrophy. *Hypertrophic pulmonary osteoarthropathy. * ...
March 1961). "Cerebral ischemia and infarction". Am Pract Dig Treat. 12: 147-54. PMID 13777430.. CS1 maint: Uses authors ... Cold shock response. *Dead space (physiology). *Decompression (diving). *Decompression theory. *Diving reflex ...
The roots of the words anemia and ischemia both refer to the basic idea of "lack of blood", but anemia and ischemia are not the ... Cold agglutinin hemolytic anemia is primarily mediated by IgM. It can be idiopathic[22] or result from an underlying condition. ... the word ischemia refers solely to the lack of blood (poor perfusion). Thus ischemia in a body part can cause localized anemic ... "Primary chronic cold agglutinin disease: an update on pathogenesis, clinical features and therapy". Hematology. 12 (5): 361-70 ...
Hearts, saphenous veins, internal-mammary-arteries and aortas of male landrace pigs were harvested and exposed to cold ischemia ... HTK-Custodiol protection of mitochondrial function after prolonged cold ischemia was observed in the myocardium but not in ... mitochondrial function remained stable even after 24 h of cold ischemia. ... Analysis of mitochondrial function can be used as a valuable approach for the assessment of cold ischemic injury in various ...
The concept of time may be discussed on several different... Explanation of cold ischemia time ... Find out information about cold ischemia time. sequential arrangement of all events, or the interval between two events in such ... redirected from cold ischemia time). Also found in: Dictionary, Thesaurus, Medical, Legal.. Related to cold ischemia time: warm ... Cold ischemia time , Article about cold ischemia time by The Free Dictionary https://encyclopedia2.thefreedictionary.com/cold+ ...
Yoshizumi T, Ikeda Y, Kaneda Y, Sueishi K. Ex Vivo Transfer of Nuclear Factor-κB Decoy Ameliorates Hepatic Cold Ischemia/ ... N2 - Cold ischemia/reperfusion injury of the hepatic graft has been attributed to the release of various inflammatory cytokines ... AB - Cold ischemia/reperfusion injury of the hepatic graft has been attributed to the release of various inflammatory cytokines ... Cold ischemia/reperfusion injury of the hepatic graft has been attributed to the release of various inflammatory cytokines. ...
Gene Expression Profiling of Cold Ischemia/Reperfusion (I/R) Injury in Murine Cardiac Isografts. Titel in Übersetzung. : Gene ... Gene Expression Profiling of Cold Ischemia/Reperfusion (I/R) Injury in Murine Cardiac Isografts. / Schneeberger, S.; Mark, W.; ... Gene Expression Profiling of Cold Ischemia/Reperfusion (I/R) Injury in Murine Cardiac Isografts. 2002. ... title = "Gene Expression Profiling of Cold Ischemia/Reperfusion (I/R) Injury in Murine Cardiac Isografts", ...
What is ischemia time? Meaning of ischemia time as a legal term. What does ischemia time mean in law? ... Definition of ischemia time in the Legal Dictionary - by Free online English dictionary and encyclopedia. ... redirected from ischemia time). Also found in: Dictionary, Thesaurus, Medical, Encyclopedia.. Related to ischemia time: cold ... Indivumeds current tumor biobank of over 17,000 patient-cases, collected with a mean cold ischemia time of less than ten ...
The use of these organs could be increased if "cold ischemia times" are limited. Donated organs that could be used to save ... The process of restoring blood flow following this period of "cold ischemia" can lead to tissue damage. To examine the ... Kidney donation after circulatory death has become common in the U.S and study suggests that limiting cold ischemia time to ... Ice cream headache or brain freeze is a temporary pain due to eating or drinking a cold substance or when exposed to cold air. ...
... ... Nathalie Le Clef, Anja Verhulst, Patrick C. DHaese, and Benjamin A. Vervaet, "Unilateral Renal Ischemia-Reperfusion as a ... "Effect of Γ-aminobutyric acid on kidney injury induced by renal ischemia-reperfusion in male and female rats: Gender-related ...
i,Results,/i,. Prolonged cold ischemia time in UW solution increased PARP-1 expression and kidney injury. Preconditioning with ... In conclusion, PARP inhibition attenuates ATN and other IR-related renal lesions in mouse kidneys under prolonged cold storage ... If confirmed, these data suggest that pharmacological manipulation of PARP activity may have salutary effects in cold-stored ... and other renal lesions related to prolonged cold ischemia/reperfusion (IR) in kidneys preserved at 4°C in University of ...
... the pathophysiology of liver I/R and regeneration making clear distinction between situations of cold and warm ischemia, as ... Ischemia-reperfusion (I/R) associated with hepatic resection and living related liver transplantation is an unsolved problem in ... type of ischemia applied (warm or cold), period of ischemia (ranging from minutes to days), extension of hepatic ischemia ( ... 4. Controversies on hepatic regeneration under warm or cold ischemia. In an attempt to expand the size of the donor pool, the ...
Cold Ischemia During Surgery. Known as: cold ischemia In surgery, the cooling of a tissue, organ, or body part after its blood ... Laparoscopic partial nephrectomy in cold ischemia: renal artery perfusion.. *Gunter Janetschek, Alaa Eldin A. Abdelmaksoud, Dr ... We examined the effects of upregulation of heme oxygenase-1 (HO-1) in steatotic rat liver models of ex vivo cold ischemia… ( ... BACKGROUND Prolonged cold ischemia time (CIT) is accompanied by delayed cadaveric renal allograft function and early allograft ...
CitacióFerreira, P., Muñoz, M., Reverter Comes, F. The effects of death and post-mortem cold ischemia on human tissue ... The effects of death and post-mortem cold ischemia on human tissue transcriptomes. ...
The cold ischemia time (CIT) was recorded. Statistical comparisons were made among HA level, CK-BB level, CIT, and graft ... CAN EFFLUENT HYALURONIC ACID OR CREATINE KINASE PREDICT SINUSOIDAL INJURY SEVERITY AFTER COLD ISCHEMIA?. ...
... and cold (4°C) ischemia on different mitochondrial functions in rat brain, liver ... Baumann, M., Bender, E., Sömmer, G. et al. Effects of warm and cold ischemia on mitochondrial functions in brain, liver and ... Effects of warm and cold ischemia on mitochondrial functions in brain, liver and kidney. *Matthias Baumann1. , ... The purpose of this work was to study the effects of warm (37°C) and cold (4°C) ischemia on different mitochondrial functions ...
Objective The purpose of this study is to describe the functional relationship between cold-ischemia time (CIT) and primary ...
The effect of oxygenated warm buffer perfusion with PGE1 before cold preservation on hepatic warm ischemia reperfusion injury. ... Journal Article] Perfusion Using Oxygenated Buffer Containing Prostaglandin E1 before Cold Preservation Prevents Warm Ischemia- ... Presentation] Perfusion by oxygenated buffer containing prostaglandin E1 prior to cold preservation prevents warm ischemia- ... Presentation] Perfusion by oxygenated buffer containing prostaglandin E1 prior to cold preservation prevents warm ischemia- ...
Effects of Cold Ischemia on Tissue Oxygenation. Additionally, mean oxy-hemoglobin concentrations were compared for cold and ... Sequential oxygenation images of a left kidney at baseline (a) and during cold ischemia (b-h) and reperfusion (i-o). Ischemia ... decreases with ischemia time, and the kidney is darkest after 30 min of ischemia, demonstrating significantly lowered %. HbO. 2 ... B. R. Laneet al., "Comparison of cold and warm ischemia during partial nephrectomy in 660 solitary kidneys reveals predominant ...
Researchers have long considered the NCI supported Cooperative Human Tissue Network (CHTN) as a source for quality collection and preservation of tissue samples from remnant surgical tissue specimens. In an organized tissue procurement setting serving a large population of researchers, the trained procurement personnel, specialized reagents and monitoried frozen storage facilities assure the availability of quality research, monitored preservation techniques and temperature controlled shipping required for successful research support.. The CHTN Midwestern Division (MWD) has experienced an increase in investigator demand for fresh tissues over the past two years. Approximately 23% of the tissues distributed by the CHTN MWD is fresh tissue. Requests for frozen and formlin-fixed paraffin embedded tissues, however, remain constant and stable. The increased interest in fresh tissue likely reflects an increased focus on the study of vital cells in controlled environments for... Read more ...
"Cold Ischemia" by people in UAMS Profiles by year, and whether "Cold Ischemia" was a major or minor topic of these publications ... Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN ... "Cold Ischemia" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Cold Ischemia" by people in Profiles over the past ten years. ...
Digital Ischemia. 14/07/2017. Cold Call: Day 1 Filed under: Cold Call-R - Tags: audioplay, creative writing, dialogue, fiction ... Leave a Reply to Cold Call: Day 15 , Digital Ischemia Cancel reply. Enter your comment here.... ... series of telephone conversations where truth comes away in layers - begins at Cold Call: Day 1 and ends at Day […] ... series of telephone conversations where truth comes away in layers - begins at Cold Call: Day 1 and ends at Day […] ...
... begins at Cold Call: Day 1 SOUND: PHONE RINGS LACRIMOSA: Still speaking to me? SìMON: (D) Ah, I suddenly thought oh shit, ... Digital Ischemia. 27/07/2017. Cold Call: Day 14 Filed under: Cold Call-R - Tags: comedy, creative writing, dialogue, drama, ... A series of telephone conversations where truth comes away in layers - begins at Cold Call: Day 1 ...
In renal transplantation, cold ischaemia (CI) determines acute rejection through innate immunity among others. Acute rejection ... In renal transplantation, cold ischaemia (CI) determines acute rejection through innate immunity among others. Acute rejection ...
... ... Conclusions IL-6/STAT3 pathway might participate to initiate cholangiecytes regeneration after cold ischemia and preservation ... Objective To investigate the role of IL-6/STAT3 pathway in the proliferation of cholangiocyte induced by cold ischemia and ... Cholangiocytes responded to extended cold preservation with severe bile duct injures and marked increase in IL-6 secretion, p- ...
Experts available for cold ischaemia consulting, expert witness, or analyst services for business, legal, and technical ... cold ischaemia Experts. To improve your results, click a Related Expert Area on the left.. ... Join our distinguished experts for cold ischaemia jobs, projects and consulting opportunities. ...
OKT3 prophylaxis in Renal Grafts with prolonged cold ischemia times: association with improvement in long term survival. ... OKT3 prophylaxis in Renal Grafts with prolonged cold ischemia times: association with improvement in long term survival ...
... the time of cold ischemia was aimed to be lower than 2 h in all cases. Cold ischemia time was 19 h (14 to 32 h) among HB donors ... The mRNA expression of HIF-1αFL after cold ischemia T(−1) and intraoperative warm ischemia T(0) was significantly higher in ... Biopsies were taken at three time points: after cold ischemia (T[−1]), after intraoperative warm ischemia (T[0]), and after ... Biopsies were taken at three time points: after cold ischemia (T[−1]), after intraoperative warm ischemia (T[0]), and after ...
Clinicians may be reluctant to transplant small pediatric kidneys that have prolonged cold ischemia time (CIT) for fear of an ... Influence of Cold Ischemia Time in Kidney Transplants From Small Pediatric Donors. ... additional deleterious effect because pediatric grafts are thought to be more sensitive to ischemia. We aimed to assess the ...
The need to reduce cold ischemia time in kidney transplantation. van der Vliet, J. Adam; Warlé, Michiel C. ... Preservation solutions for static cold storage of abdominal allografts: which is best?. Parsons, Ronald F.; Guarrera, James V. ... Role of temperature in reconditioning and evaluation of cold preserved kidney and liver grafts. Minor, Thomas; von Horn, ... Donor risk factors, retrieval technique, preservation and ischemia/reperfusion injury in pancreas transplantation. Maglione, ...
Influence of Pancreas Import and Cold Ischemia on Outcomes Following Pancreas Transplantation.. M. Khan,1 H. El-Hennawy,1 J. ... Influence of Cold Ischemia Time in Combination With Donor Ischemic Events on Kidney Transplant Outcomes. ... Proposed changes in pancreas transplant (PT) allocation may improve organ sharing but increase cold ischemia time (CIT). ... Influence of Pancreas Import and Cold Ischemia on Outcomes Following Pancreas Transplantation. Am J Transplant. 2016;16 (suppl ...
Temporal dynamics of phosphorylation changes resulting from cold ischemia. A, fuzzy c-means clustering of temporal profiles for ... Stress-response kinases were affected by cold ischemia. A, kinases detected with and without regulated phosphosites were mapped ... TableS3 - Table S3: Comparison of cold ischemia time point data for phosphorylation-sites and proteins analyzed by RPPA and ... Ischemia induced common phosphorylation events in ovarian and basal-like/luminal breast cancer tumor samples. A, scatter plots ...
Cold Ischemia. The common definition for cold ischemia in surgery is the time between the chilling of a tissue, organ, or body ... The effects of warm and cold ischemia can be classified into ischemia-induced metabolic responses including posttranslational ... Effects of cold ischemia on gene expression: a review and commentary. Biopreserv Biobank. 2016;14(6):548-58.CrossRefPubMed ... Cold ischemia triggers a cascade of noxious effects and responses to hypoxia and stress, all of which affect the quality of the ...
Phenotype and Course of Renal Tubular Cell Death during Cold Ischemia versus Cold Ischemia Followed by Transplant. ... Cellular Sources of Cytokine Production during Cold Ischemia Induced AKI after Kidney Transplant. S. Jain1, R. Plenter2, T. ... Purpose: Delayed graft function portends reduced 5-year graft survival and is associated with prolonged cold ischemia (CI). The ... Jain S, Plenter R, Nydam T, Jani A. Cellular Sources of Cytokine Production during Cold Ischemia Induced AKI after Kidney ...
  • Cold ischemia/reperfusion injury of the hepatic graft has been attributed to the release of various inflammatory cytokines. (elsevier.com)
  • Decoy ODNs against nuclear factor-κB binding site delivery improved the viability of the hepatic graft against cold ischemia/reperfusion injury in the rodent liver transplantation model. (elsevier.com)
  • Marzieh Vafapour, Mehdi Nematbakhsh, Ramesh Monajemi, Safoora Mazaheri, Ardeshir Talebi, Nahid Talebi, and Soheyla Shirdavani, "Effect of Γ-aminobutyric acid on kidney injury induced by renal ischemia-reperfusion in male and female rats: Gender-related difference. (hindawi.com)
  • We test the hypothesis that PARP inhibition can decrease acute tubular necrosis (ATN) and other renal lesions related to prolonged cold ischemia/reperfusion (IR) in kidneys preserved at 4°C in University of Wisconsin (UW) solution. (hindawi.com)
  • Until now, renal ischemia-reperfusion (IR) injury has been inevitable in transplantation, resulting in the cell death of renal tubular epithelial cells. (hindawi.com)
  • Ischemia-reperfusion (I/R) associated with hepatic resection and living related liver transplantation is an unsolved problem in clinical practice. (intechopen.com)
  • In most cases, in clinical practice, liver surgery involves both ischemia-reperfusion (I/R) injury and regeneration [ 1 ]. (intechopen.com)
  • Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both. (semanticscholar.org)
  • H-NMR-based metabolic signatures of mild and severe ischemia/reperfusion injury in rat kidney transplants. (semanticscholar.org)
  • BACKGROUND Severe ischemia/reperfusion (IR) injury is a risk factor for delayed graft function. (semanticscholar.org)
  • Mitochondrial defects and heterogeneous cytochrome c release after cardiac cold ischemia and reperfusion. (semanticscholar.org)
  • Mitochondria play a critical role in myocardial cold ischemia-reperfusion (CIR) and induction of apoptosis. (semanticscholar.org)
  • Heme oxygenase-1 overexpression protects rat hearts from cold ischemia/reperfusion injury via an antiapoptotic pathway. (semanticscholar.org)
  • BACKGROUND Ischemia/reperfusion (I/R) injury is one of the most important causes of the early graft loss. (semanticscholar.org)
  • Upregulation of heme oxygenase-1 protects genetically fat Zucker rat livers from ischemia/reperfusion injury. (semanticscholar.org)
  • In this study, we perfused rat livers from DCD before cold preservation with oxygenated warm buffer containing Prostaglandin E1 and observed bile production, liver cell death, mitochondrial function of liver cell and so on during reperfusion with oxygenated buffer. (nii.ac.jp)
  • Presentation] Perfusion by oxygenated buffer containing prostaglandin E1 prior to cold preservation prevents warm ischemia-reperfusion injury in liver grafts from non-heart-beating donors. (nii.ac.jp)
  • To better understand the dynamics of intraoperative renal ischemia and recovery of renal oxygenation during reperfusion, a visible reflectance imaging system (VRIS) was developed to measure renal oxygenation during renal artery clamping in both cooled and warm porcine kidneys. (spiedigitallibrary.org)
  • Objective To investigate the role of IL-6/STAT3 pathway in the proliferation of cholangiocyte induced by cold ischemia and reperfusion injury. (oriprobe.com)
  • The extent of graft damage after ischemia-reperfusion reflects the balance between deleterious events and protective factors. (asnjournals.org)
  • For investigating whether HO-1 and VEGF play a role in the adaptive response to ischemia-reperfusion injury after renal transplantation, kidney biopsies were analyzed from living ( n = 45) and cadaveric ( n = 16) donors, obtained at three time points: at the end of cold storage T(−1), after warm ischemia T(0), and after reperfusion T(+1). (asnjournals.org)
  • It is concluded that the lower expression of HO-1, VEGF 165 , and Bcl-2 in cadaveric donor kidneys can reflect a defective adaptation against ischemia-reperfusion injury that may affect their function in the short term. (asnjournals.org)
  • An appropriate protective response may tip the balance toward a less hazardous event related to the damage of ischemia-reperfusion process. (asnjournals.org)
  • Cold ischemia/reperfusion injury of the hepatic graft has been attributed to the release of various inflammatory cytokines. (elsevier.com)
  • Decoy ODNs against nuclear factor-κB binding site delivery improved the viability of the hepatic graft against cold ischemia/reperfusion injury in the rodent liver transplantation model. (elsevier.com)
  • Here we demonstrate that in contrast to the proinflammatory role of HMGB1, preconditioning with HMGB1 results in protection following hepatic ischemia/reperfusion (I/R). Pretreatment of mice with HMGB1 significantly decreased liver damage after I/R. The protection observed in mice pretreated with HMGB1 was associated with a higher expression of IL-1R-associated kinase-M, a negative regulator of TLR4 signaling, compared with controls. (jimmunol.org)
  • Ischemia/reperfusion (I/R) 4 injury is a pathophysiologic process whereby hypoxic organ damage is accentuated following return of blood flow and oxygen delivery. (jimmunol.org)
  • HMGB1 levels are increased by ischemia/reperfusion in the liver and activation of the innate immune system by HMGB1 in this context requires TLR4-dependent signaling. (jimmunol.org)
  • Cold storage (CS) remains the gold standard for organ preservation worldwide, although it is inevitably associated with ischemia/reperfusion injury (IRI). (fujita-hu.ac.jp)
  • The hematopoetic cytokine erythropoietin (EPO) has been shown to reduce programmed cell death and tissue destruction in experimental models of acute kidney ischemia-reperfusion injury. (clinicaltrials.gov)
  • A recent experimental study revealed that cobalt administration to rats caused up-regulation of EPO, and diminished the degree of renal injury caused by ischemia-reperfusion (I/R), suggesting that EPO may also play an important role in renal ischemic preconditioning. (clinicaltrials.gov)
  • Numerous pharmacological interventions aiming to prevent ischemia-reperfusion injuries failed to reduce the rate of DGF. (springer.com)
  • During the transplantation procedure, the kidneys suffer from warm (harvesting and grafting before vascular anastomosis) and cold ischemia (preservation) followed by reperfusion. (springer.com)
  • The association of hypoxic and ischemia-reperfusion injuries decreases renal blood flow, increases oxidative stress and triggers the release of pro-inflammatory mediators which activate leukocyte adhesion and immune phenomena. (springer.com)
  • Mitochondria play a central role in the pathophysiology of ischemia-reperfusion injuries. (springer.com)
  • To elucidate the role of DAP12 in pulmonary ischemia/reperfusion injury (IRI), we took advantage of a clinically relevant mouse model of transplant-mediated lung IRI. (jimmunol.org)
  • Ischemia/reperfusion injury (IRI) is a clinically relevant noninfectious inflammatory insult that can affect a variety of tissues. (jimmunol.org)
  • In the case of lung transplantation, where reperfusion of a lung transiently subjected to cold ischemia is an inherent component of this procedure, IRI is a critical determinant of short- and long-term morbidity and mortality ( 3 ). (jimmunol.org)
  • In kidney transplantation, injury due to ischemia and reperfusion is an inevitable process resulting many times in delayed graft function (DGF) that is currently characterized by the need of dialysis within the first week after transplantation. (scielo.br)
  • Ischemia and reperfusion injury (IRI) also promotes activation of the innate and adaptive responses of the immune system, leading to processes with great potential to produce significant graft harm. (scielo.br)
  • The chronological expression (over 24 h) of two adhesion molecules [intercellular adhesion molecule-1 (ICAM-1) and CD11b/CD18 (Mac-1)] and the extent of liver damage, including injury to sinusoidal endothelial cells (SECs) and hepatocyte apoptosis, were investigated under two conditions of rat liver ischemia-reperfusion (I/R) injury: reversible (30 min) and fatal I/R (60 min). (physiology.org)
  • hepatic injury induced by ischemia-reperfusion (I/R) is an important clinical problem that often follows circulatory shock with resuscitation, as well as many types of liver surgery, including transplantation and tumor resection. (physiology.org)
  • Graft cellular death was an early event detected at H3 and seems to be one of the first ischemia reperfusion injuries. (biomedcentral.com)
  • Donor deceased after cardiac death (DCD), is an additional potential source of kidney graft which is more prone to severe ischemia reperfusion injury (IRI), primary non-function (PNF), and delayed graft function (DGF). (biomedcentral.com)
  • He is interested in the pathogenesis of kidney ischemia-reperfusion injury and transplant rejection, and molecular control of urinary malignancies. (vchri.ca)
  • Reduction of cold ischemia-reperfusion injury by graft-expressing clusterin in heart transplantation. (vchri.ca)
  • Expression of transforming growth factor-beta1 limits renal ischemia-reperfusion injury. (vchri.ca)
  • Loss of clusterin expression worsens renal ischemia-reperfusion injury. (vchri.ca)
  • Among abdominal solid organ transplantation, pancreatic grafts are prone to develop severe ischemia reperfusion injury-associated graft damage, leading eventually to early graft loss. (jove.com)
  • Which pathways trigger the role of complement in ischaemia/reperfusion injury? (frontiersin.org)
  • Investigations into the role of complement in ischemia/reperfusion (I/R) injury have identified common effector mechanisms that depend on the production of C5a and C5b-9 through the cleavage of C3. (frontiersin.org)
  • MBL binds to carbohydrate residues on microorganisms, or altered-self endogenous ligands that arise in pathological conditions such as ischemia/reperfusion (I/R) injury. (frontiersin.org)
  • Here, we investigated this possibility in mice by studying the role of conventional DCs (cDCs) in liver ischemia/reperfusion (I/R) injury, a model of sterile inflammation. (jci.org)
  • Renal surgery and coronary artery bypass grafting can produce renal ischemia and reperfusion injury. (wikipedia.org)
  • In studies of mice models, a high-fat diet can induce greater injury to the kidney with renal ischemia-reperfusion as compared to mice with normal diet. (wikipedia.org)
  • Improving the outcome of kidney transplantation by ameliorating renal ischemia reperfusion injury: lost in translation? (biomedcentral.com)
  • During kidney transplantation ischemia reperfusion injury (IRI) occurs, which is a risk factor for acute kidney injury, delayed graft function and acute and chronic rejection. (biomedcentral.com)
  • Vascular Endothelial Growth Factor-B Overexpressing Hearts Are Not Protected From Transplant-Associated Ischemia-Reperfusion Injury. (harvard.edu)
  • Ischemia/Reperfusion Injury and Hepatocellular Carcinoma Recurrence After Liver Transplantation: Cancer at WIT's End? (harvard.edu)
  • Human Lungs Airway Epithelium Upregulate MicroRNA-17 and MicroRNA-548b in Response to Cold Ischemia and Ex Vivo Reperfusion. (amedeo.com)
  • Renal macrophages are key cells in controlling processes related to inflammation or repair after ischemia-reperfusion injury. (asnjournals.org)
  • Although macrophages from a donor kidney could also guide adaptive immune responses against renal tissue by virtue of their ability to act as antigen-presenting cells, data are lacking on whether donor-derived renal macrophages can function in this manner after being subjected to transplant-induced ischemia-reperfusion injury. (asnjournals.org)
  • Background In donor kidneys subjected to ischemia-reperfusion injury during kidney transplant, phagocytes coexpressing the F4/80 and CD11c molecules mediate proinflammatory responses and trigger adaptive immunity in transplantation through antigen presentation. (asnjournals.org)
  • No data are currently available regarding the effects of transplant-induced ischemia-reperfusion injury on the ability of donor-derived resident renal macrophages to act as professional antigen-presenting cells. (asnjournals.org)
  • We also assessed the modifications of donor renal macrophages after reversible ischemia-reperfusion injury in a mouse model of congeneic renal transplantation. (asnjournals.org)
  • Results Cold ischemia and reversible ischemia-reperfusion injury dampened antigen presentation by renal macrophages, skewed their polarization toward the M 2 phenotype, and increased surface expression of IL-1R8, diminishing activation mediated by toll-like receptor 4. (asnjournals.org)
  • Conclusions IL-1R8 is a key regulator of donor renal macrophage functions after ischemia-reperfusion injury, crucial to guiding the phenotype and antigen-presenting role of these cells. (asnjournals.org)
  • Advances in our understanding of ischemic post-conditioning have facilitated the development of DCD heart resuscitation strategies that can be used to minimize ischemia-reperfusion injury at the time of organ procurement. (frontiersin.org)
  • However when the kidney is submitted to a stress such as ischemia reperfusion injury there is a defined change in TSPO expression towards more proximal areas of the nephron, and the protein can be detected as high as proximal tubular cells and the Bowman Capsule. (eurekaselect.com)
  • Herein we review the potential use of TSPO-directed treatment for ischemia reperfusion injury, particularly regarding pre-conditioning of the organ. (eurekaselect.com)
  • R. Thuillier and T. Hauet, "Role of Translocator Protein in Renal Ischemia Reperfusion, Renal Preservation and Acute Kidney Injury", Current Molecular Medicine (2012) 12: 413. (eurekaselect.com)
  • If confirmed, these data suggest that pharmacological manipulation of PARP activity may have salutary effects in cold-stored organs at transplantation. (hindawi.com)
  • Acute tubular necrosis (ATN) induced by IR injury contributes to the development of delayed graft function (DGF), which remains an important complication of kidney transplantation and, despite advances in cold storage, is a major risk factor for acute rejection and long-term kidney allograft dysfunction [ 3 ]. (hindawi.com)
  • The liver grafts which are taken from the donors after cardiac death(DCD)and preserved immediately in cold solution show bad function after transplantation. (nii.ac.jp)
  • Cold ischemia time during ORGAN TRANSPLANTATION begins when the organ is cooled with a cold perfusion solution after ORGAN PROCUREMENT surgery, and ends after the tissue reaches physiological temperature during implantation procedures. (uams.edu)
  • Lo S, MacMillan-Crow LA, Parajuli N. Renal cold storage followed by transplantation impairs proteasome function and mitochondrial protein homeostasis. (uams.edu)
  • Renal ischemia that occurs intraoperatively during procedures requiring clamping of the renal artery (such as renal procurement for transplantation and partial nephrectomy for renal cancer) is known to have a significant impact on the viability of that kidney. (spiedigitallibrary.org)
  • In renal transplantation, cold ischaemia (CI) determines acute rejection through innate immunity among others. (oup.com)
  • Conclusions IL-6/STAT3 pathway might participate to initiate cholangiecytes regeneration after cold ischemia and preservation injury,which might benefit biliary recovery after fiver transplantation. (oriprobe.com)
  • Influence of Pancreas Import and Cold Ischemia on Outcomes Following Pancreas Transplantation. (atcmeetingabstracts.com)
  • Khan M, El-Hennawy H, Rogers J, Farney A, Orlando G, Reeves-Daniel A, Palanisamy A, Stratta R. Influence of Pancreas Import and Cold Ischemia on Outcomes Following Pancreas Transplantation. (atcmeetingabstracts.com)
  • In rat liver transplantation, the addition of VEGF to cultured sinusoidal endothelial cells attenuated the damage induced by cold preservation, inhibiting cellular apoptosis ( 17 ), which is possibly mediated by the increased expression of the antiapoptotic proteins such as A1 and Bcl-2 ( 18 ). (asnjournals.org)
  • Cold ischemia time and allograft outcomes in live donor renal transplantation: Is live donor organ transport feasible? (uab.edu)
  • While transport of the kidney is an attractive alternative, there is concern that prolonged cold ischemia time (CIT) would diminish the benefits of live donor transplantation (LDTx). (uab.edu)
  • Transient episodes of ischemia are encountered during solid organ transplantation, trauma, hypovolemic shock, and elective liver resection, when inflow occlusion or total vascular exclusion is used to minimize blood loss. (jimmunol.org)
  • This large international trial could be the defining work towards establishing ex-vivo heart perfusion as a viable clinical option for donor heart preservation for transplantation to overcome the challenges of cold ischemic storage,' said Dr. Waleed Hassanein , President and CEO of TransMedics, Inc. (prnewswire.com)
  • Since the advent of organ transplantation, the cornerstone of organ preservation has been cold ischemic storage (essentially placing organs on ice). (prnewswire.com)
  • Partly because of the limitations of cold storage, it is estimated that globally 70% to 80% of donor hearts cannot ultimately be used for transplantation. (prnewswire.com)
  • TransMedics has developed the world's only portable medical device capable of overcoming the limitations of cold storage for organ transplantation. (prnewswire.com)
  • Deciphering the respective role of renal warm and cold ischemia is of pivotal interest in the transplantation process. (biomedcentral.com)
  • Using a preclinical pig model of renal auto-transplantation, we investigated the consequences of warm and cold ischemia on early innate and adaptive responses as well as graft outcome. (biomedcentral.com)
  • The injury an organ sustains during recovery, preservation, and transplantation occurs primarily as a result of ischemia and hypothermia. (medscape.com)
  • The second, the cold ischemic phase, occurs when the organ is preserved in a hypothermic state prior to transplantation into the recipient. (medscape.com)
  • Our aim was to investigate the impact of the ischemia periods on development of AKI in DCD liver transplantation. (eur.nl)
  • Conclusions Combined WIT is a newly defined period of warm ischemia in DCD liver transplantation. (eur.nl)
  • During storage of the transplant, the temperature is reduced to approximately 4 °C. During this cold ischemia period, metabolism is significantly reduced which allows for prolonged preservation of the organ until transplantation. (biomedcentral.com)
  • Impact of Cold Ischemia Time on Outcomes of Liver Transplantation: A Single Center Experience. (seattlechildrens.org)
  • Kidney donation after circulatory death has become common in the U.S and study suggests that limiting cold ischemia time to less than 12 hours can reduce kidney wastage. (medindia.net)
  • Currently, the most effective preservation strategy to reduce ischemic injury during prolonged cold storage is to decrease renal oxygen demand by using both hypothermia and preservation solutions (University of Wisconsin (UW) solution) together. (hindawi.com)
  • Organ preservation solutions play an important role in the prevention of DGF, especially in organs from expanded criteria donors or exposed to prolonged cold ischemia. (hindawi.com)
  • Cholangiocytes responded to extended cold preservation with severe bile duct injures and marked increase in IL-6 secretion, p-STAT3 and cyclinDl protein expression, followed by compensatory cholangiocytes regeneration. (oriprobe.com)
  • ABSTRACT Liquid perfluorocarbon (PFC) instillation has been studied experimentally as an adjuvant therapy in the preservation of lung grafts during cold ischemia . (bvsalud.org)
  • In such donors, different ischemic conditions are associated such as warm ischemia (WI) and cold ischemia (CS) characterized respectively by an ischemic period at body temperature initiated by cardiac arrest ensuing a low and/or no blood flow and by a hypothermic preservation of kidneys. (biomedcentral.com)
  • [ 3 ] Organ ischemia and preservation disrupt all these relations. (medscape.com)
  • Decrease in donor heart injury by recombinant clusterin protein in cold preservation with University of Wisconsin solution. (vchri.ca)
  • Bruinsma BG, Wu W, Ozer S, Farmer A, Markmann JF, Yeh H, Uygun K. Warm ischemic injury is reflected in the release of injury markers during cold preservation of the human liver. (harvard.edu)
  • Evaluation of cold ischemia for preservation of testicular function during partial orchiectomy in the rat model. (harvard.edu)
  • Conclusion HAR can improve the survival rate of liver grafts with severe long-term cold preservation injury. (youdao.com)
  • The availability of a clinically approved ex situ heart perfusion device now allows DCD heart preservation in a normothermic beating state and minimizes exposure to incremental cold ischemia. (frontiersin.org)
  • Certain DCD kidneys were at higher risk of failing when compared with kidneys from brain dead donors, but only when the cold ischemia time was >12 hours. (medindia.net)
  • We found that use of DCD kidneys is variable throughout the United States, that the outcomes are generally excellent, and that the use of these organs could probably be safely increased if cold ischemia times are limited," said Dr. Gill. (medindia.net)
  • In conclusion, PARP inhibition attenuates ATN and other IR-related renal lesions in mouse kidneys under prolonged cold storage in UW solution. (hindawi.com)
  • The impact of ischemia time during open nephron sparing surgery on solitary kidneys: a multi-institutional study. (semanticscholar.org)
  • Mean relative oxy-hemoglobin concentrations decrease more significantly during ischemia for normothermic kidneys compared to hypothermic kidneys. (spiedigitallibrary.org)
  • Clinicians may be reluctant to transplant small pediatric kidneys that have prolonged cold ischemia time (CIT) for fear of an additional deleterious effect because pediatric grafts are thought to be more sensitive to ischemia. (ovid.com)
  • 13% of the cadaveric kidneys were from pediatric donors less than 3 years of age and were transplanted en bloc. (nih.gov)
  • Kidneys were subjected to either 60 min-warm ischemia (WI) or auto-transplanted after cold storage for 24 h at 4°C (CS), or both conditions combined (WI + CS). (biomedcentral.com)
  • DI-fusion OKT3 prophylaxis in Renal Grafts with prolonged cold ischemia. (ac.be)
  • The objective of this study was to evaluate whether vaporized PFC is also protective of lung grafts at different cold ischemia times . (bvsalud.org)
  • Cold Ischemia And Renal Graft Survival: A Paired Analysis Comparing First And Second Grafts From The Same Donor. (com.es)
  • OBJECTIVE: To compare the characteristics, clinical course, and survival of pairs of renal grafts from the same donor, with special interest in cold ischemia times (CIT) as a risk factor for graft survival. (com.es)
  • These grafts are associated with an increased sensitivity to IRI and decreased graft outcome due to prolonged ischemia and donor comorbidity. (biomedcentral.com)
  • In addition to limb ischemia, other organs can become ischemic, causing: Renal ischemia (nephric ischemia) Mesenteric ischemia Cerebral ischemia Cardiac ischemia In order to treat acute limb ischaemia there are a series of things that can be done to determine where the occlusion is located, the severity, and what the cause was. (wikipedia.org)
  • DCD donors do not develop the physiological changes of DBD donors, but suffer from prolonged warm ischemia times during cardiac arrest. (biomedcentral.com)
  • Myocardial ischemia, also called cardiac ischemia, reduces the heart muscle's ability to pump blood. (mayoclinic.org)
  • To overcome such obstacles, we developed a novel reconditioning method for donor organs named hydrogen flush after cold storage (HyFACS), which is just an end-ischemic H 2 flush directly to donor organs ex vivo, and, herein, we report its therapeutic impact against hepatic IRI. (fujita-hu.ac.jp)
  • After 24-hour CS in UW solution, livers were cold-flushed with H 2 solution (1.0 ppm) via the portal vein (PV), the hepatic artery (HA), or both (PV + HA). (fujita-hu.ac.jp)
  • PURPOSE The safe duration of ischemia during nephron sparing surgery remains controversial. (semanticscholar.org)
  • 12 There remains much controversy as to the specific duration of ischemia that results in renal injury and at what point cold ischemia should be employed. (spiedigitallibrary.org)
  • Kidney ischemia can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the duration of ischemia was used as a biomarker, it was found that it has significant flaws in predicting renal function outcomes. (wikipedia.org)
  • Why does Exercise in Cold Air Increase Susceptibility to Myocardial Ischaemia? (vumc.nl)
  • Cold stress may also be used to model conditions where increases in myocardial oxygen demand are not met by anticipated increases in coronary blood flow, as occurs in older adults. (cdc.gov)
  • Myocardial ischemia occurs when blood flow to the heart muscle (myocardium) is obstructed by a partial or complete blockage of a coronary artery by a buildup of plaques (atherosclerosis). (mayoclinic.org)
  • Myocardial ischemia occurs when blood flow to your heart is reduced, preventing the heart muscle from receiving enough oxygen. (mayoclinic.org)
  • Myocardial ischemia might also cause serious abnormal heart rhythms. (mayoclinic.org)
  • Treatment for myocardial ischemia involves improving blood flow to the heart muscle. (mayoclinic.org)
  • Making heart-healthy lifestyle choices is important in treating and preventing myocardial ischemia. (mayoclinic.org)
  • Some people who have myocardial ischemia don't have any signs or symptoms (silent ischemia). (mayoclinic.org)
  • Myocardial ischemia occurs when the blood flow through one or more of your coronary arteries is decreased. (mayoclinic.org)
  • Atherosclerosis is the most common cause of myocardial ischemia. (mayoclinic.org)
  • The clot might block an artery and lead to sudden, severe myocardial ischemia, resulting in a heart attack. (mayoclinic.org)
  • Coronary artery spasm is an uncommon cause of myocardial ischemia. (mayoclinic.org)
  • Type 1 and type 2 diabetes are linked to an increased risk of myocardial ischemia, heart attack and other heart problems. (mayoclinic.org)
  • Laparoscopic partial nephrectomy in cold ischemia: renal artery perfusion. (semanticscholar.org)
  • Renal Ischemia and Function After Partial Nephrectomy: A Collaborative Review of the Literature. (harvard.edu)
  • It therefore appears that hypothermia can prevent effectively mitochondrial dysfunction due to ischemia. (springer.com)
  • Ischemia Modified by Topical Hypothermia. (indigo.ca)
  • Jain S, Plenter R, Nydam T, Jani A. Cellular Sources of Cytokine Production during Cold Ischemia Induced AKI after Kidney Transplant [abstract]. (atcmeetingabstracts.com)
  • Acute limb ischaemia (ALI) occurs when there is a sudden lack of blood flow to a limb. (wikipedia.org)
  • Warm ischemia occurs after the blood supply has been cut off while the organ is still in the donor. (biomedcentral.com)
  • The use of these organs could be increased if "cold ischemia times" are limited. (medindia.net)
  • Given its safety, simplicity, and cost-effectiveness, end-ischemic HyFACS may be a novel pretransplant conditioning for cold-stored donor organs. (fujita-hu.ac.jp)
  • Scientists also did not repeat Dr. Suda's success for other organs those are more resistant to cold storage and freezing than the brain. (cryonics.org)
  • The coexistense of an abdominal aortic aneurysm with ectopic main renal vasculature complicates aortic surgery and mandates a focused imaging evaluation and a carefully planned operation to minimize renal ischemia. (biomedsearch.com)
  • Animal experiments focus on understanding the mechanism behind IRI and try to find methods to minimize IRI either before, during or after ischemia. (biomedcentral.com)
  • Greater length of renal ischemia is associated with subsequent worse recovery of renal function, whereas cooling of the kidney allows for longer exposure to ischemia. (spiedigitallibrary.org)
  • Exposure to acute heat or cold stress elicits numerous physiological responses aimed at maintaining body temperatures. (cdc.gov)
  • It was 72% for 2 hours of warm ischemia and only 50% for 3 hours of warm exposure. (cryonics.org)
  • It was 74% for 6 hours of cold ischemia, 59% for 12 hours, 50% for 18 hours, 43% for 24 hours, and 0% for 48 hours of cold exposure. (cryonics.org)
  • Early Intraductal L-Glutamine Perfusion Improves Pig Islet Isolation Outcome After Warm and Cold Ischemia. (ox.ac.uk)
  • 3. The study of warm and cold ischemia of rat brain tissues. (cryonics.org)
  • it is the sum of warm and cold ischemia times. (thefreedictionary.com)
  • Methods We evaluated the phenotype and function of intragraft CD11c + F4/80 + renal macrophages after cold ischemia. (asnjournals.org)
  • Signaling pathways regarding the pathophysiology of liver I/R and regeneration making clear distinction between situations of cold and warm ischemia, as well as liver regeneration with or without vascular occlusion, will be addressed. (intechopen.com)
  • What causes kidney ischemia is not entirely known, but several pathophysiology relating to this disease have been elucidated. (wikipedia.org)
  • We conclude that vaporized PFC reduces the production of free radicals and the number of pulmonary structural changes resulting from cold ischemia . (bvsalud.org)
  • Renal epithelial and endothelial cells were subjected to in vitro cold storage in saline at 4°C followed by rewarming in media (CS/REW) at 37°C that simulates in vivo CI+Txp. (atcmeetingabstracts.com)
  • The purpose of this work was to study the effects of warm (37°C) and cold (4°C) ischemia on different mitochondrial functions in rat brain, liver and kidney. (springer.com)
  • After l0 to 60 minutes of ischemia at 37°C the energy coupled respiration as well as the ADP-induced malate-aspartate shuttle activity in brain and liver mitochondria or the rate of mitochondrial ATP synthesis in kidney were significantly decreased. (springer.com)
  • Boime J, Smith EE, Hunter Jr FE: The role of fatty acids in mitochondrial changes during liver ischemia. (springer.com)
  • The process of restoring blood flow following this period of "cold ischemia" can lead to tissue damage. (medindia.net)
  • The primary intervention in acute limb ischaemia is emergency embolectomy using a Fogarty Catheter, providing the limb is still viable within the 4-6h timeframe. (wikipedia.org)
  • however, DAXX mediates both Fas-dependent and TGF-beta-induced apoptosis and renal induction of TGF-beta is well documented in renal ischemia studies. (wikipedia.org)