Colchicine: A major alkaloid from Colchicum autumnale L. and found also in other Colchicum species. Its primary therapeutic use is in the treatment of gout, but it has been used also in the therapy of familial Mediterranean fever (PERIODIC DISEASE).Gout Suppressants: Agents that increase uric acid excretion by the kidney (URICOSURIC AGENTS), decrease uric acid production (antihyperuricemics), or alleviate the pain and inflammation of acute attacks of gout.Lumicolchicines: Three, alpha, beta, and gamma isomers of ultraviolet degradation products of colchicine that lack many of the physiological actions of the parent; used as experimental control for colchicine actions.Tubulin Modulators: Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.Tubulin: A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from SPERM FLAGELLUM; CILIA; and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to COLCHICINE; VINCRISTINE; and VINBLASTINE.Microtubules: Slender, cylindrical filaments found in the cytoskeleton of plant and animal cells. They are composed of the protein TUBULIN and are influenced by TUBULIN MODULATORS.Tropolone: A seven-membered aromatic ring compound. It is structurally related to a number of naturally occurring antifungal compounds (ANTIFUNGAL AGENTS).Cytochalasin B: A cytotoxic member of the CYTOCHALASINS.Familial Mediterranean Fever: A group of HEREDITARY AUTOINFLAMMATION DISEASES, characterized by recurrent fever, abdominal pain, headache, rash, PLEURISY; and ARTHRITIS. ORCHITIS; benign MENINGITIS; and AMYLOIDOSIS may also occur. Homozygous or compound heterozygous mutations in marenostrin gene result in autosomal recessive transmission; simple heterozygous, autosomal dominant form of the disease.Demecolcine: An alkaloid isolated from Colchicum autumnale L. and used as an antineoplastic.Vinblastine: Antitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)Podophyllotoxin: A lignan (LIGNANS) found in PODOPHYLLIN resin from the roots of PODOPHYLLUM plants. It is a potent spindle poison, toxic if taken internally, and has been used as a cathartic. It is very irritating to skin and mucous membranes, has keratolytic actions, has been used to treat warts and keratoses, and may have antineoplastic properties, as do some of its congeners and derivatives.Cytochalasins: 11- to 14-membered macrocyclic lactones with a fused isoindolone. Members with INDOLES attached at the C10 position are called chaetoglobosins. They are produced by various fungi. Some members interact with ACTIN and inhibit CYTOKINESIS.Colchicum: A genus of poisonous, liliaceous plants. The roots (corms) of Colchicum autumnale, the fall crocus or meadow saffron, yield COLCHICINE, which is used as a biochemical tool and to treat gout. Other members of this genus yield saffron dye, flavoring agents, and aromatics.Gout: Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.Cytochalasin D: A fungal metabolite that blocks cytoplasmic cleavage by blocking formation of contractile microfilament structures resulting in multinucleated cell formation, reversible inhibition of cell movement, and the induction of cellular extrusion. Additional reported effects include the inhibition of actin polymerization, DNA synthesis, sperm motility, glucose transport, thyroid secretion, and growth hormone release.Griseofulvin: An antifungal agent used in the treatment of TINEA infections.CycloheptanesPostpericardiotomy Syndrome: A nonspecific hypersensitivity reaction caused by TRAUMA to the PERICARDIUM, often following PERICARDIOTOMY. It is characterized by PERICARDIAL EFFUSION; high titers of anti-heart antibodies; low-grade FEVER; LETHARGY; loss of APPETITE; or ABDOMINAL PAIN.Pericarditis: Inflammation of the PERICARDIUM from various origins, such as infection, neoplasm, autoimmune process, injuries, or drug-induced. Pericarditis usually leads to PERICARDIAL EFFUSION, or CONSTRICTIVE PERICARDITIS.Vinca Alkaloids: A group of indole-indoline dimers which are ALKALOIDS obtained from the VINCA genus of plants. They inhibit polymerization of TUBULIN into MICROTUBULES thus blocking spindle formation and arresting cells in METAPHASE. They are some of the most useful ANTINEOPLASTIC AGENTS.Cytoskeleton: The network of filaments, tubules, and interconnecting filamentous bridges which give shape, structure, and organization to the cytoplasm.Arthritis, Gouty: Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular.Nocodazole: Nocodazole is an antineoplastic agent which exerts its effect by depolymerizing microtubules.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Polyploidy: The chromosomal constitution of a cell containing multiples of the normal number of CHROMOSOMES; includes triploidy (symbol: 3N), tetraploidy (symbol: 4N), etc.Chromosome Segregation: The orderly segregation of CHROMOSOMES during MEIOSIS or MITOSIS.Cell Division: The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.Chromosomes: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Diploidy: The chromosomal constitution of cells, in which each type of CHROMOSOME is represented twice. Symbol: 2N or 2X.Armenia: An ancient country in western Asia, by the twentieth century divided among the former USSR, Turkey, and Iran. It was attacked at various times from before the 7th century B.C. to 69 B.C. by Assyrians, Medes, Persians, the Greeks under Alexander, and the Romans. It changed hands frequently in wars between Neo-Persian and Roman Empires from the 3d to 7th centuries and later under Arabs, Seljuks, Byzantines, and Mongols. In the 19th century Armenian nationalism arose but suffered during Russo-Turkish hostilities. It became part of the Soviet Republic in 1921, with part remaining under Turkey. (Webster's New Geographical Dictionary, 1988)Universal Precautions: Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.Panax notoginseng: A plant species of the genus PANAX. It contains damarane-type tetracyclic TRITERPENES. The common names of Sanchi or Tienchi are also used for Panax pseudoginseng which is distinguished in containing oleanane-type pentacyclic triterpenoids.JordanCloning, Organism: The formation of one or more genetically identical organisms derived by vegetative reproduction from a single cell. The source nuclear material can be embryo-derived, fetus-derived, or taken from an adult somatic cell.Nuclear Transfer Techniques: Methods of implanting a CELL NUCLEUS from a donor cell into an enucleated acceptor cell.Teratoma: A true neoplasm composed of a number of different types of tissue, none of which is native to the area in which it occurs. It is composed of tissues that are derived from three germinal layers, the endoderm, mesoderm, and ectoderm. They are classified histologically as mature (benign) or immature (malignant). (From DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1642)Drug Prescriptions: Directions written for the obtaining and use of DRUGS.Prescription Drugs: Drugs that cannot be sold legally without a prescription.Seminoma: A radiosensitive, malignant neoplasm of the testis, thought to be derived from primordial germ cells of the sexually undifferentiated embryonic gonad. There are three variants: classical (typical), the most common type; anaplastic; and spermatocytic. The classical seminoma is composed of fairly well differentiated sheets or cords of uniform polygonal or round cells (seminoma cells), each cell having abundant clear cytoplasm, distinct cell membranes, a centrally placed round nucleus, and one or more nucleoli. In the female, a grossly and histologically identical neoplasm, known as dysgerminoma, occurs. (Dorland, 27th ed)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Nausea: An unpleasant sensation in the stomach usually accompanied by the urge to vomit. Common causes are early pregnancy, sea and motion sickness, emotional stress, intense pain, food poisoning, and various enteroviruses.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Drug Administration Schedule: Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience.

The role of oocyte transcription, the 5'UTR, and translation repression and derepression in Drosophila gurken mRNA and protein localization. (1/2012)

The establishment of the major body axes of the Drosophila egg and future embryo requires strict regulation of gurken mRNA and protein localization. Here, we show that grk mRNA and protein localization is dependent on synthesis of grk transcripts in the oocyte nucleus and on RNA localization elements in the 5' portion of the transcript. We also show that gurken mRNA and protein localization is dependent on region-specific translation of gurken transcripts and identify K10 as a probable negative regulator of gurken translation.  (+info)

Perturbation of mammalian cell division. III. The topography and kinetics of extrusion subdivision. (2/2012)

If mitotic-arrested, cold-stored HeLa cells are incubated at 37 degrees C a proportion of the population divides by an aberrant process which we have called subdivision by extrusion. This process has been studied by time-lapse photography and shown to differ from normal cleavage in several respects. The cell surface becomes more generally mobile and, instead of producing the precisely localized furrowing activity of cytokinesis, gives rise to multiple surface protrusions. These protrusions enlarge at the expense of the parent cell and develop into a cluster of small daughter cells (mini segregants). The surface structure of the cell, as seen by scanning electron microscopy, also changes; the microvilli characteristic of interphase, metaphase and cleaving HeLa cells are lost during extrusion and the cell surface becomes smooth. Extrusion activity is much more variable than division by cleavage in terms of both topography and kinetics, and in general takes longer to complete. Some cells in the cold-treated populations divide by mixtures of cleavage and extrusion or by cleavage alone. The relative numbers of cells dividing in different ways vary with the conditions of pretreatment and incubation of the mitotic cells. The greater the perturbation (e.g. longer cold storage), the greater the proportion of extruding rather than cleaving cells. Human diploid cells can also be induced to subdivide by extrusion. Possible mechanisms underlying the different types of division activity are discussed.  (+info)

Analysis of the stimulation-inhibition paradox exhibited by lymphocytes exposed to concanavalin A. (3/2012)

High doses of Concanavalin A (Con A), which normally inhibit T-lymphocyte stimulation as measured by increases in DNA synthesis, cause these lymphocytes to become committed to mitogenesis while also generating a dominant but reversible negative growth signal. The observed response to the stimulatory signal as measured by the rate of commitment to enter the S phase (i.e., the rate at which the stimulation becomes lectin independent) increases with lectin concentration even in the inhibitory range. The generation of this positive signal is prevented by treating the cells with colchicine. Cells that have become committed but are also simultaneously blocked from entering the S phase by the high doses of Con A can begin synthesizing DNA if the lectin is released by adding a competitive inhibitor of binding. Experiments done in agarose cultures in which lymphocytes are kept from contact with each other suggest that the reversible inhibitory signal is mediated by structures in the individual cells rather than as a result of agglutination. Continuously dividing cells of the lymphoid line P388 are also individually and reversibly inhibited by Con A. These findings are considered in terms of the relation of the inhibitory signal to the microtubular components of cell surface modulating assemblies made up of submembranous arrays of microtubules, microfilaments, and associated proteins.  (+info)

Pseudogout attack associated with chronic thyroiditis and Sjogren's syndrome. (4/2012)

A 66-year-old woman, diagnosed with chronic thyroiditis at age 63, presented with anorexia and fatigue. Therapy for the chronic thyroiditis consisted of levothyroxine sodium (100 microg/day). Her symptoms were attributed to the insufficient supply of levothyroxine sodium. Following a dosage increase to 150 microg/day, she suffered from an acute attack of pseudogout. Clinical features were complicated by Sjogren's syndrome, which appeared after treatment onset. Pseudogout was effectively treated by colchicine after administration of diclofenac sodium failed to alleviate the symptoms. Pseudogout is a recognized complication of thyroid replacement therapy, but association with Sjogren's syndrome has not been previously reported.  (+info)

Familial Mediterranean fever--renal involvement by diseases other than amyloid. (5/2012)

BACKGROUND: In patients with familial Mediterranean fever (FMF) renal involvement is usually in the form of AA amyloidosis. There is increasing evidence that renal involvement may be due to diseases other than amyloid as well. METHODS: Amongst 302 children with FMF we observed and followed 28 with typical clinical and laboratory features of vasculitis. The diagnosis of FMF was established according to the Tel Hashomer criteria. RESULTS: Polyarteritis nodosa, protracted febrile attacks and Henoch-Schonlein purpura were diagnosed in 4, 13, and 11 patients, respectively. The presentation was often difficult to distinguish from FMF attacks, but protracted febrile attacks lasting several weeks, hypertension, thrombocytosis, and dramatic responses to corticosteroid therapy that were observed in many cases were different from what is observed in classical FMF. CONCLUSIONS: We suggest that FMF, perhaps as a consequence of impaired control of inflammatory responses, predisposes to vasculitis with renal involvement.  (+info)

Influence of centriole behavior on the first spindle formation in zygotes of the brown alga Fucus distichus (Fucales, Phaeophyceae). (6/2012)

The influence of centrioles, derived from the sperm flagellar basal bodies, and the centrosomal material (MTOCs) on spindle formation in the brown alga Fucus distichus (oogamous) was studied by immunofluorescence microscopy using anti-centrin and anti-beta-tubulin antibodies. In contrast to a bipolar spindle, which is formed after normal fertilization, a multipolar spindle was formed in polyspermic zygote. The number of mitotic poles in polyspermic zygotes was double the number of sperm involved in fertilization. As an anti-centrin staining spot (centrioles) was located at these poles, the multipolar spindles in polyspermic zygotes were produced by the supplementary centrioles. When anucleate egg fragments were fertilized, chromosome condensation and mitosis did not occur in the sperm nucleus. Two anti-centrin staining spots could be detected, microtubules (MTs) radiated from nearby, but the mitotic spindle was never produced. When a single sperm fertilized multinucleate eggs (polygyny), abnormal spindles were also observed. In addition to two mitotic poles containing anti-centrin staining spots, extra mitotic poles without anti-centrin staining spots were also formed, and as a result multipolar spindles were formed. When karyogamy was blocked with colchicine, it became clear that the egg nucleus proceeded independently into mitosis accompanying chromosome condensation. A monoastral spindle could be frequently observed, and in rare cases a barrel-shaped spindle was formed. However, when a sperm nucleus was located near an egg nucleus, the two anti-centrin staining spots shifted to the egg nucleus from the sperm nucleus. In this case, a normal spindle was formed, the egg chromosomes arranged at the equator, and the associated MTs elongated from one pole of the egg spindle toward the sperm chromosomes which were scattered. From these results, it became clear that paternal centrioles derived from the sperm have a crucial role in spindle formation in the brown algae, such as they do during animal fertilization. However, paternal centrioles were not adequate for the functional centrosome during spindle formation. We speculated that centrosomal materials from the egg cytoplasm aggregate around the sperm centrioles and are needed for centrosomal activation.  (+info)

Flow cytometric cell cycle analysis of cultured porcine fetal fibroblast cells. (7/2012)

Normal development of nuclear transfer embryos is thought to be dependent on transferral of nuclei in G0 or G1 phases of the cell cycle. Therefore, we investigated the cell cycle characteristics of porcine fetal fibroblast cells cultured under a variety of cell cycle-arresting treatments. This was achieved by using flow cytometry to simultaneously measure cellular DNA and protein content, enabling the calculation of percentages of cells in G0, G1, S, and G2+M phases of the cell cycle. Cultures that were serum starved for 5 days contained higher (p < 0.05) percentages of G0+G1 (87.5 +/- 0. 7) and G0 cells alone (48.3 +/- 9.7) compared with rapidly cycling cultures (G0+G1: 74.1 +/- 3.0; G0: 2.8 +/- 1.2). Growth to confluency increased (p < 0.05) G0+G1 percentages (85.1 +/- 2.8) but did not increase G0 percentages (6.0 +/- 5.3) compared to those in cycling cultures. Separate assessment of small-, medium-, and large-sized cells showed that as the cell size decreased from large to small, percentages of cells in G0+G1 and G0 alone increased (p < 0.05). We found 95.2 +/- 0.3% and 72.2 +/- 12.0% of small serum-starved cells in G0+G1 and G0 alone, respectively. Cultures were also treated with cell cycle inhibitors. Treatment with dimethyl sulfoxide (1%) or colchicine (0.5 microM) increased percentages of cells in G0 (24.8 +/- 20.0) or G2+M (37.4 +/- 4.6), respectively. However, cells were only slightly responsive to mimosine treatment. A more complete understanding of the cell cycle of donor cells should lead to improvements in the efficiency of nuclear transfer procedures.  (+info)

Effect of the microtubule polymerizing agent taxol on contraction, Ca2+ transient and L-type Ca2+ current in rat ventricular myocytes. (8/2012)

1. Microtubules form part of the cytoskeleton. Their role in adult ventricular myocytes is not well understood although microtubule proliferation has previously been linked with reduced contractile function. 2. We investigated the effect of the anti-tumour drug taxol, a known microtubule polymerizing agent, on Ca2+ handling in adult rat ventricular myocytes. 3. Treatment of cells with taxol caused proliferation of microtubules. 4. In taxol-treated cells there was a reduction in the amplitude of contraction, no significant effect on the amplitude of L-type Ca2+ current, but a significant reduction in the amplitude of the Ca2+ transient. 5. Caffeine was used to release Ca2+ from the sarcoplasmic reticulum (SR). There was a significant reduction in the ratio of electrically stimulated : caffeine-induced Ca2+ transients in taxol-treated cells. This observation is consistent with the hypothesis that taxol reduces fractional SR Ca2+ release. 6. We suggest that the negative inotropic effect of taxol may, at least in part, be the result of reduced release of Ca2+ from the SR. Microtubules may be important regulators of Ca2+ handling in the heart.  (+info)

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TY - JOUR. T1 - Novel colchicine derivatives and their anti-cancer activity. AU - Johnson, Lorelei. AU - Goping, Ing Swie. AU - Rieger, Aja. AU - Mane, Jonathan Y.. AU - Huzil, Torin. AU - Banerjee, Asok. AU - Luduena, Richard. AU - Hassani, Bashar. AU - Winter, Philip. AU - Tuszynski, Jack A.. PY - 2017/9/1. Y1 - 2017/9/1. N2 - In this paper we provide an overview of the status of various colchicine derivatives in preclinical development with special focus on their anti-cancer activity. We discuss several groups of compounds that have been designed to differentially bind with specific affinities for tubulin β isotypes, especially in regard to βIII, which is commonly over-expressed in cancer. Computational prediction, protein-based and cell-based assays are summarized as well as some animal tests conducted on these compounds. It is concluded that an untapped potential exists for exploiting the colchicine scaffold as a pharmacophore with the possibility of increasing its affinity for tubulin ...
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The effects of free drug and tubulin-drug complexes on steady-state GTP/GDP-associated microtubules and on equilibrium guanosine 5-[beta,gamma-imido]triphosphate-associated microtubules are compared. The addition of colchicine or the tubulin-colchicine complex (TuCol) to steady-state microtubules induces microtubule disassembly. Only limited disassembly of equilibrium microtubules is observed under similar conditions. Addition of colchicine or the bifunctional colchicine analogue 2-methoxy-5-(2,3 ,4-trimethoxyphenyl) tropone to preassembled steady-state or equilibrium microtubules does induce disassembly, but establishment of the new steady state or equilibrium is very slow. These observations are related to the fact that TuCol readily adds to the microtubule end, but is only incorporated into the lattice with difficulty. As a result, microtubule growth is effectively inhibited and the critical concentration is significantly increased. Nevertheless, drug-induced disassembly can be extremely ...
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It has been used for centuries to treat and prevent gouty attacks and more recently to prevent attacks of autoi.Colchicine is contraindicated in patients with renal or hepatic impairment AND who are receiving inhibitors of P-glycoprotein (P-gp) or strong cytochrome P450.Colchicine is the generic form of the brand-name drug Colcrys, used to prevent and relieve the symptoms of gout.Colcrys (Colchicine) - Drug Interactions, Contraindications,. (Colchicine) - Drug Interactions, Contraindications,. (colchicine) is a substrate of.. Indications for the anti-inflammatory drug colchicine could be expanded to.The action of colchicine is potentiated by alkalinizing agents.Colchicine-induced neuromuscular toxicity and rhabdomyolysis have ...
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Clonazépam 250 à à 0.1/k 500 à à 4 Clopidorel 75 Codéine à m Colchicine 1 1 à à 20m Diazépam 2 à Diclofénac Dioxine 0.25 à 0.50 Diltiazem 60.The disruption of microtubules by treating bovine aortic endothelial cells with 10-7-10-5 M colchicine caused apoptosis,.For colchicine, exposure of embryogenic callus to the 2.5 m M colchicine for 24 h was the most effective in creating tetraploid (13%) plants. Revue / Journal Title.Livneh A, Zemer O., Siegal B., Laar A, Sohar E., Pras M Colchicine prevents kidney transplant amyloidosis in Familial Mediterranean Fever. Nephron. 1992; 60: 418-422 ...
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BioAssay record AID 214727 submitted by ChEMBL: Tested for the inhibition of binding of 5 uM [3H]-colchicine to purified tubulin at 37 degree Centigrade.
How To Buy Generic Colchicine OTC. Colchicine is an effective active ingredient used to treat acute gout, where there is severe inflammation as a result of high uric acid crystals formed in the toes joins. Colchicine works by reducing the number of white blood cells which travel into the inflamed areas. This helps break the cycle of inflammation and reduces swelling and pain. It will have been prescribed if you are unable to take anti-inflammatory painkillers, which are the medicines most often used to ease a gout attack. Colchicine is also marketed as Colcrys (trademark). ...
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Drug-induced injury (DILI) is a frequent cause of abnormal liver tests and a leading cause of liver failure in the United States. Colchicine has long been used as a systemic anti-inflammatory agent for treatment of gout by inhibiting mitotic activity and neutrophil function. We present the first case of colchicine-induced hepatoxicity, supported by histopathologic findings characteristic of colchicine-induced injury and resolution of liver enzyme abnormalities after its discontinuation. Colchicine-associated DILI has implications for the evaluation of patients with abnormal liver tests and gout, especially for patients with alcoholism and non-alcoholic fatty liver disease, in whom there is an increased incidence of gout ...
Redman, C.M.; Banerjee, D.; Manning, C.; Huang, C.Y.; Green, K., 1978: In vivo effect of colchicine on hepatic protein synthesis and on the conversion of proalbumin to serum albumin
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Electron micrographs of sections of the labellar chemosensilla of the blowfly, Phormia regina, showed that treatment with sodium deoxycholate (DOC; 7.2 mM for 2 min) destroyed the distal processes of the receptors from up to 10 microns from the tip of the sensillum, but these processes regenerated almost completely within 0.5 h. However, when DOC treatment was preceded by colchicine treatment (25 mM for 2 min), greater than 10 h was required for complete regeneration. Sugar receptor responses supported these findings and disclosed a more detailed time course of regeneration after DOC treatment: without colchicine pretreatment, the destroyed distal process completely regenerated in 0.3-1.0 h, but with pretreatment, regeneration began at 3 h and reached the chemosensillar tip at 8 h at the earliest. Hardly any depression of the response was observed for 8 h after treatment with colchicine alone, but a transient depression was detected at 12 h. Based on these results, the role of microtubules in ...
This study presents the biological validations of the rational synthesis of pyrrole-containing colchicine site agents based on our refined colchicine binding site model, docking and 3D QSAR methodologies. With this refined binding model, we designed molecules that, as predicted, bind more optimally within the colchicine domain and have superior biological potencies and specificity as compared with earlier generation pyrrole-based colchicine site agents. In particular, the 2,3,4 trimethoxyphenyl analog, NT-7-16, showed excellent, low nanomolar potency in a variety of sensitive and drug resistant cancer cell lines, was more potent than CA-4 in its ability to inhibit the polymerization purified tubulin, and had excellent antitumor activity in a MDA-MB-435 xenograft model without evidence of toxicities.. Our previous modeling and biological studies showed that an ethyl ester is optimal at the C2 substitution of the pyrrole, providing favorable alkyl length and hydropathic properties into the sites ...
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Activation by Microtubule-Promoting Cosolvents. These metrics are regularly updated to reflect usage leading up to the last few days. February 3, "Letters to Editor: Wheat is typically tetraploid and rye diploid, with their triploid hybrid infertile; treatment of triploid triticale with colchicine gives fertile hexaploid triticale.. Biochemical Pharmacology 78 9 A fluorescence stopped flow study of colchicine binding to tubulin. Soft Matter 7 24 Microtubules are long polymers made of smaller units monomers of the protein tubulin. Symptoms of toxicity include gastrointestinal upset, fever, muscle painlow blood cell countsand organ failure.. More:. ...
We will investigate the ability of colchicine to stabilise vulnerable coronary plaque via suppression of neutrophil function in ACS patients undergoing percutaneous coronary intervention.
We will investigate the ability of colchicine to stabilise vulnerable coronary plaque via suppression of neutrophil function in ACS patients undergoing percutaneous coronary intervention.
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Колхицин Bremner W. J., Paulsen С. A. Colchicine and testicular function in man. - New Engl. J. Med., 1976, 294, 1384.Ertel M. H., Miller J. C, Akgun S., Wallace S. L. Radioimmunoassay for colchicine in plasma and urine. - Science, 1976, 193, 233.Goldfinger S. E. Colchicine for familial Meditarranean ...
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A study of the interaction of colchicine and purified rat brain microtubule protein is presented. Experimental data agree with a theory derived to describe the system. Protein stabilized with 0.1 mM vinblastine and 1 mM GTP lost the ability to bind colchicine in a first-order reaction, with a rate constant of 1.1 ± 0.1 x 10-5 sec -1. The colchicine-microtubule protein complex appeared to be stable. The rate constant for the second-order association of colchicine and microtubule protein is 128.7 ± 6.5 M-1 sec-1, while the rate constant for dissociation is 8.1 ± 0.8 x 10-6 sec-1. The dissociation constant calculated from these two numbers is 6.3 x 10-8 M. By using other ligands to perturb the interaction between colchicine and microtubule protein, the affinities of these ligands for microtubule protein could be measured. The methods developed are applicable in general for ligands of microtubule protein. Podophyllotoxin binds firmly to microtubule protein (Kd = 0.28 ± 0.06 µM), while ...
ABT-751 (CAS: 857447-92-8) is a novel bioavailable tubulin-binding and antimitotic sulfonamide agent with IC50 of about 1.5 and 3.4 μM in neuroblastoma and non-neuroblastoma cell lines, respectively. ABT-751 binds to the colchicine-binding site on beta-tu
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The initial results of an ongoing Greek study into the benefits of the anti-inflammatory agent colchicine in treating Covid-19 are
Synchronized VSMCs were obtained by the method of double-thymidine block,colchicine treatment and serum starvation . Synchronized growth was monitored by flow cytometry. All the synchronized VSMCs distribution ration were 89.22% (±3.54%) at G0 phase, (66.74±7.16%) at G1/S phase, (63.24±4.06)% at S phase and (51.64±11.18)% at G2/M phase. The expression of ORC1 mRNA and CyclinA in a quiescent stage of VSMC was not significantly found, After synchronized, peaked(50.4%) at G2/M of CyclinA, and decreased(1.03%) at G2/M of ORC1, CyclinA in preventing the ORC1 from bind during G2/Mphase. The expression of ORC1 protein and CyclinA had a same change as ORC1 mRNA and CyclinA in different cell cycles of VSMC by flow cytometry (P,0.001). ...
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Key clinical point: Colchicine reduced markers of inflammation in patients with metabolic syndrome.Major finding: C-reactive protein dropped by 2.8 mg/L in the active group but increased slightly in the placebo group.Study details: A randomized, placebo-controlled study comprising 40 patients
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A colleague of mine has yeast contaimination in cultures of a protozoan he works on. He would like not to use any of the common treatments to deal with this problem but instead would like to try drugs that he knows this protozoan are resistant to. So, does anyone have an idea of what toxic doses of pyrimethamine, methotrexate and colchicine are for yeast? Thanks Mike Forte forte at ohsu.edu ...
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COLCHICINE. What are the aims of this leaflet?. This leaflet has been written to help you understand more about colchicine. It tells you what it is, how it works, how it is used to treat skin conditions, and where you can find out more about it.. What is colchicine and how does it work? Colchicine is an extract of the plant Colchicum autumnale (autumn crocus), used medically since ancient times. In the UK, colchicine is currently only licensed for the treatment of gout, but is used for many conditions.. Colchicine modifies the response of the immune system. It has been found to be helpful in conditions with too many neutrophils (white blood cells) in the skin.. What skin conditions are treated with colchicine?. Colchicine has been used in a number of skin conditions, some of which are quite rare. Occasionally colchicine is used in combination with other treatments.. Will colchicine cure my skin condition?. Depending on your skin complaint, colchicine may cure or improve it, but it does not work ...
the optimum dose? Colchicine in acute gouty. to treat and prevent recurrence of acute gout [3]. The maximum dose of colchicine for treating an acute.Colchicine. - Acute attack of gout,. 4.2 Dosage and delivery system Acute attack of gout: 1st day: 3 tablets (1 in the morning,.Moins de fibres plus de maladies cardiovasculaires. 30-10-2013 Lu:5062 Maladies Santé TN. Moins de fibres plus de maladies cardiovasculaires Les fibres alimentaires.Terkeltaub RA, et al. High versus low dosing of oral colchicine for early acute gout flare:. et la colchicine à dose élevée (répartie sur 6 heures).Attack of gout Colchicine is indicated to prevent. Colchicine Dosage. The usual recommended dosage of Colchicine for Acute gouty arthritis attacks is 1.Allopurinol during acute gout attacks did not. indomethacin and colchicine within 7 days of onset of an acute attack. efficacité aux doses reconnues.Thiazide diuretic with a history of gout. PPI for peptic ulcer disease at full therapeutic dosage for,8 weeks. ...
Looking for the definition of COLCHICINE? Find out what is the full meaning of COLCHICINE on geptsite.info! The Webs largest and most authoritative acronyms and abbreviations resource. Colchicine definition, categories, type and other relevant information provided by All Acronyms. COL stands for Colchicine.. Meer weten over anticonceptie. Bijsluiters van de verschillende anticonceptiemethoden vind je op [Den] European Medicines Agency, Reproduction is authorised according the colchicine abbreviation is acknowledged. 01 July EMA Human Medicines Evaluation Division. Table of nationally authorised medicinal colchicine abbreviations. Ensuing substance(s): ethinylestradiol levonorgestrel. Thalidomide No. : PSUSA. Colchicine definition, categories, type and other relevant information provided by All Acronyms. CLC stands for Colchicine. Other Dangerous Abbreviations Misinterpretation is also possible with abbreviations not specifically targeted by JCAHO. When the abbreviation "PC" (after meals) was ...
Herbaceous peony is one of the most famous traditional flowers in China, with more than 4000 years of cultivation history. However, most peonies are diploid. The present study aimed at exploring an effective way to produce polyploidy using seeds or buds from three herbaceous peony cultivars (Fen Yu Nu, Zhu Sha Pan and Zhong Sheng Fen) by colchicine treatment. For seeds, NaClO (4%) solution was a more suitable disinfectant than HgCl2 (0.1%) solution, and the optimum disinfection time was 12 min. The best induction medium for Zhu Sha Pan was 1/2 MS + 0.5 mg L-1 6‑BA + 0.2 mg L-1 GA3. Three chimeras were obtained from explants of Fen Yu Nu, at a rate of 7.14%, when seeds were first immersed in 0.1% colchicine solution for 12 h and then zygotic embryos were transferred to culture medium. For underground buds, HgCl2 (0.1%) solution was a more suitable disinfectant than NaClO (4%) solution, and the optimum disinfection time was 10 min. The best induction medium for Zhong Sheng Fen was ...
TY - JOUR. T1 - Colchicine therapy of the renal amyloidosis of ulcerative colitis. AU - Meyers, Samuel. AU - Janowitz, Henry D.. AU - Gumaste, Vivek V.. AU - Abramson, Ruth G.. AU - Berman, Laurence J.. AU - Venkataseshan, V. S.. AU - Dickman, Steven H.. PY - 1988/6. Y1 - 1988/6. N2 - Two patients with severe proteinuria, due to renal amyloidosis complicating chronic ulcerative colitis, improved remarkably with colchicine therapy. One patient with an initial daily urine protein excretion of 13.70 g had a reduction within 2 mo to 6.50 g and to 0.37 g after 9 yr. The other patients daily urine protein excretion was 9.00 g. This was reduced to 5.10 g/day within 3 mo and was 0.53 g/day by 8 mo. Renal function remained stable or improved during the period of therapy. Colchicine resulted in rapid and prolonged benefit for these patients, despite their amyloid-induced nephrotic syndrome.. AB - Two patients with severe proteinuria, due to renal amyloidosis complicating chronic ulcerative colitis, ...
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Improvement of colchicine oral bioavailability by incorporating eugenol in the nanoemulsion as an oil excipient and enhancer Qi Shen, Ying Wang, Yi ZhangSchool of Pharmacy, Shanghai Jiao Tong University, Dongchuan Road 800, Shanghai 200240, People’s Republic of ChinaAbstract: The effect of eugenol on colchicine transport across an isolated rat intestinal membrane was studied using an in vitro diffusion chamber system. We found that eugenol increased the absorptive transport of the drug efficiently. The effect of eugenol on intestinal absorption of colchicine in an oral administrative nanoemulsion formulation was also demonstrated in vivo. The colchicine nanoemulsion was prepared with isopropyl myristate, eugenol, Tween80, ethanol and water, and eugenol was used as an oil phase in the formulation; an average particle size of this nanoemulsion was 41.2 ± 7.2 nm. The permeation of colchicine in the nanoemulsion across the intestinal membrane was significantly different from that of the control
Mor, A. "Familial Mediterranean fever successfully treated with etanercept". J Clin Rheumatol. vol. 13. 2007. pp. 38-40. (This paper is a case report of a patient responding to etanercept who was unable to tolerate colchicine for FMF.). El-Shanti, H. "Familial Mediterranean fever in Arabs". Lancet. vol. 367. 2006. pp. 1016-24. (A review paper of FMF in Arabs.). Barzilai, A. "Erysipelas-like erythema of familial Mediterranean fever: clinicopathologic correlation". J Am Acad Dermatol. vol. 42. 2000. pp. 791-5. (This paper is a clinicopathologic study of erysipelas-like erythema.). Ben-Chetrit, E. "Familial Mediterranean fever in the world". Arthritis Rheum. vol. 61. 2009. pp. 1447-53. (An overview of the epidemiology of FMF.). Yuksel, S. "Clinical improvement with infliximab in a child with amyloidosis secondary to familial Mediterranean fever". Rheumatology (Oxford). vol. 45. 2006. pp. 1307-8. (A case report of an FMF patient who was recalcitrant to colchicine but responded to regular infliximab ...
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ColchicineEdit. Clarithromycin has been observed to have a dangerous interaction with colchicine as the result of inhibition of ... Combining these two drugs may lead to fatal colchicine toxicity, particularly in patients with renal insufficiency.[8] ... It should not be used with colchicine in people with kidney or liver impairment.[8] ...
Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha tubulin gene that encodes a protein 99% to the mouse testis-specific Tuba3 and Tuba7 gene products. This gene is located in the 13q11 region, which is associated with the genetic diseases Clouston hidrotic ectodermal dysplasia and Kabuki syndrome. Alternative splicing has been observed for this gene and two variants have been identified.[4] ...
Yurdakul S, Mat C, Tüzün Y, Ozyazgan Y, Hamuryudan V, Uysal O, Senocak M, Yazici H (2001). "A double-blind trial of colchicine ... Colchicine may decrease the frequency of attacks.[1] The condition often improves with the passage of time.[1] ... and colchicine can be useful for treating some genital ulcers, erythema nodosum, and arthritis.[30] ... either as a result of the condition itself or of a side effect of concomitant medication such as Colchicine, which is known to ...
Like retinoids, colchicines can also improve skin manifestations. It is able to bind to the ends of microtubules to prevent its ... Terkeltaub RA (2009). "Colchicine update. Seminars in arthritis and rheumatism". 38 (6): 411-419. Mattuci-Cerinic; et al. (1998 ... Because microtubules are involved in cell division, signal transduction and regulation of gene expression, colchicine can ... "Colchicine treatment in a case of pachydermoperiostosis with acroosteolysis". Rheumatol Int. 8: 185-188. Jajic I, Jajic Z (1992 ...
Oral colchicine or dapsone are often used for this purpose. If rapid control of symptoms is needed, a short course of high-dose ... agents such as methotrexate and azathioprine may be used in truly refractory cases not responsive to colchicine or dapsone. ...
Colchicine is biosynthesized from the amino acids phenylalanine and tryptophan. Paclitaxel, in contrast, is a tubulin ... These include the tubulin polymerization inhibitor colchicine isolated from the Colchicum autumnale (autumn crocus flowering ...
Treatment in most cases is with NSAIDs and possibly colchicine. Steroids may be used if those are not appropriate. Typically ... Alabed, S; Cabello, JB; Irving, GJ; Qintar, M; Burls, A (Aug 28, 2014). "Colchicine for pericarditis". The Cochrane Database of ... Colchicine may be added to the above as it decreases the risk of further episodes of pericarditis. Severe cases may require one ...
Colchicine is an alternative for those unable to tolerate NSAIDs. At high doses, side effects (primarily gastrointestinal upset ... They are often used in combination with either an NSAID or colchicine for the first three to six months. Urate-lowering ... Colchicine may interact with other commonly prescribed drugs, such as atorvastatin and erythromycin, among others. ... van Echteld, I; Wechalekar, MD; Schlesinger, N; Buchbinder, R; Aletaha, D (Aug 15, 2014). "Colchicine for acute gout". The ...
... and others feel it is safe to take colchicine during pregnancy. Approximately 5-10% of FMF cases are resistant to colchicine ... The exact way in which colchicine suppresses attacks is unclear. While this agent is not without side effects (such as ... Attacks are self-limiting, and require analgesia and NSAIDs (such as diclofenac). Colchicine, a drug otherwise mainly used in ... In these cases, adding anakinra to the daily colchicine regimen has been successful. FMF affects groups of people originating ...
... s should not be taken with colchicine as it may lead to colchicine toxicity. Symptoms of colchicine toxicity include ... John R. Horn & Philip D. Hansten (2006). "Life Threatening Colchicine Drug Interactions. Drug Interactions: Insights and ...
Colchicine is known to cause alopecia. One case report described a patient who accidentally ate the tubers and then experienced ... As with other members of the Colchicaceae, this plant contains high levels of colchicine, a toxic alkaloid. It also contains ...
Berg, Ulf; Bladha, Håkan; Mpamposa, Konstantinos (2004). "Stereochemical variations on the colchicine motif. Peracid oxidation ...
Fertile tetraploids were produced using colchicine. The name Jostaberry was created via combining the German words for ...
... the effect of certain colchicine derivatives". In 1921 he completed his habilitation (qualification for professorship) under ...
A few cases of myopathy have been reported when atorvastatin is given with colchicine.[18] ...
Colchicine and dimethyl sulfoxide are most commonly used.[1] Dogs taking colchicine must be monitored closely for signs of bone ...
"Combined treatment with vitamin E and colchicine in the early stages of Peyronie's disease". BJU International. 91 (6): 522-4. ... A combination of Vitamin E and colchicine has shown some promise in delaying progression of the condition.[17] ...
... and colchicine MASON RM (June 1954). "Studies on the Effect of Probenecid ('Benemid') in Gout". Ann. Rheum. Dis. 13 ...
the first trial of colchicine in PBC); Alkaline phosphatase isoenzymes; Hepatitis B & C; Tumour markers of primary liver cancer ...
Colchicine may decrease the frequency of attacks. The condition often improves with the passage of time. While rare in the ... Azathioprine, when used in combination with interferon alpha-2b also shows promise, and colchicine can be useful for treating ... either as a result of the condition itself or of a side effect of concomitant medication such as Colchicine, which is known to ... "A double-blind trial of colchicine in Behcet's syndrome". Arthritis Rheum. 44 (11): 2686-92. doi:10.1002/1529-0131(200111)44:11 ...
They have not been compared to other treatment options such as colchicine or glucocorticoids.[5][6] ...
Colchicine, azathioprine and NSAIDs have also been used. Garcia-Rodiguez JA, Pattullo A (2013). "Idiopathic granulomatous ...
Other compounds they discovered include colchicine and veratrine. The crater Caventou on the Moon is named after him. Haas L ( ...
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Colchicine as first-choice therapy for recurrent pericarditis: results of the CORE (COlchicine for REcurrent pericarditis) ... Conventional therapy + colchicine. Conventional therapy alone. RRR (95% CI). NNT (CI). Recurrence. 21%. 45%. 53% (10 to 76). 5 ... Relief with colchicine. Circulation. 1990;82:1117-20. [PubMed ID: 2205414] 5. Artom G, Koren-Morag N, Spodick DH, et al. ... Conventional therapy plus colchicine vs conventional therapy alone for recurrent pericarditis at mean 20 months‡ Outcomes. ...
Colchicine is an atypical anti-inflammatory that is one of the primary treatments for gout. Users either take small amounts ... Colchicine was eventually isolated in 1820 by French chemists and was finally approved by the FDA in 1939. As a landscaping ... Although Autumn Crocus is considered poisonous to humans and livestock, the seeds and corns contain the alkaloid colchicine. ...
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Use of colchicine as an adjunct to conventional nonsteroidal anti-inflammatory drug therapy for acute viral pericarditis may ... Colchicine in addition to conventional therapy for acute pericarditis: results of the COlchicine for acute PEricarditis (COPE) ... Colchicine as first-choice therapy for recurrent pericarditis: results of the CORE (COlchicine for REcurrent pericarditis) ... 10.7 percent for an anti-inflammatory plus colchicine; P = .004; number needed to treat [NNT] = 5). Addition of colchicine also ...
Colchicine is indicated for both acute attacks and long-term maintenance. It is not completely understood why colchicine is an ... Colchicine, either twice daily or intermittently for acute attacks, is the mainstay of therapy. Therapy should be altered if ... Although colchicine is generally an effective therapy for FMF, other agents, such as interferon alpha, etanercept, and anakinra ... First-line therapy for FMF is colchicine. Dosing is 0.6mg or 0.5mg twice daily (depending on dosage form available). This is ...
colchicine. Further reading[edit]. *"colchicine" in le Trésor de la langue française informatisé (The Digitized Treasury of the ... Retrieved from "https://en.wiktionary.org/w/index.php?title=colchicine&oldid=48314170" ...
Colchicine: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Colchicine is not a pain reliever and cannot be used to treat pain that is not caused by gout or FMF. Colchicine is in a class ... When colchicine is used to prevent gout attacks or to treat FMF, it is usually taken once or twice a day. When colchicine ( ... Colchicine (Colcrys) is also used to relieve the pain of gout attacks when they occur. Colchicine (Colcrys) is also used to ...
A list of US medications equivalent to Colchicine is available on the Drugs.com website. ... Colchicine is a medicine available in a number of countries worldwide. ... Colchicine. In the US, Colchicine (colchicine systemic) is a member of the drug class antigout agents and is used to treat ... Colchicine Mylan. Mylan, Netherlands. *Colchicine Opocalcium. A.C.P., Belgium; Galéniques Vernin, Tunisia; Mayoly Spindler, ...
H-Colchicine; Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-; Colchicin; Colchicina; N-Acetyl ...
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... colchicine significantly reduced CRP and IL-6 levels, suggesting the reduction in recurrences is mediated through the ... Colchicine, on the other hand--a low-cost medicine that has been around for more than 2000 years--possesses a unique ... "Discontinuing colchicine for intolerance or adverse reaction before one month of therapy was rare, suggesting that one month ... The mean recurrence-free time in the placebo-treated patients was 68.9 days, compared with 82.2 days in the colchicine-treated ...
Colchicine, an anti-inflammatory drug used to treat gout and rheumatic disease, may be a promising treatment for COVID-19, a ... Colchicine, an anti-inflammatory drug used to treat gout and rheumatic disease, may be a promising treatment for COVID-19, a ... "Colchicine is an old drug utilized for its anti-inflammatory and antimitotic effects," lead author Spyridon Deftereos, MD, PhD ... The mean event-free survival time was 18.6 (.83) days in the control group vs 20.7 (.31) days in the colchicine group (log rank ...
Colchicine is also used in addition to other therapy in the treatment of pericarditis. Colchicine is used widely in the ... Colchicine in combination with probenecid has been FDA-approved prior to 1982. In August 2009, colchicine won FDA approval in ... Colchicine should not be taken with macrolide antibiotics such as erythromycin or clarithromycin as this may lead to colchicine ... In 1833, P.L. Geiger purified an active ingredient, which he named colchicine. The determination of colchicines structure ...
Ingestion of colchicine typically leads to profuse vomiting and diarrhea, which can be bloody, followed by hypovolemic shock ... Fatal colchicine overdose: report of a case and review of the literature. Am J Emerg Med 1998;16:603-8. ... Environmental: Detection of colchicine in environmental samples. Case classification * Suspected: A case in which a potentially ... Finkelstein Y, Aks SE, Hutson JR, Juurlink DN, Nguyen P, Dubnov-Raz G, Pollak U, Koren G, Bentur Y. Colchicine poisoning: the ...
Colchicine-induced rhabdomyolysis.. Boomershine KH1.. Author information. 1. Pharmacy Department, Trident Health System, 9330 ... Colchicine was thought to be the causative factor for rhabdomyolysis in conjunction with chronic renal failure and elevated ... To report a case of rhabdomyolysis occurring during treatment with colchicine.. CASE SUMMARY: A 44-year-old African American ... After discontinuation of colchicine, creatinine kinase concentrations declined and the patients ability to walk improved. ...
Case Definition: Colchicine Clinical description, lab criteria for diagnosis, case classification, & additional resources ...
Lactic acidosis, prostaglandin E1, and colchicine. Br Med J 1978; 1 :651 ... Lactic acidosis, prostaglandin E1, and colchicine.. Br Med J 1978; 1 doi: https://doi.org/10.1136/bmj.1.6113.651-a (Published ...
A list of US medications equivalent to Probenecid and Colchicine Actavis is available on the Drugs.com website. ... Probenecid and Colchicine Actavis is a medicine available in a number of countries worldwide. ... Probenecid and Colchicine Actavis. Ingredient matches for Probenecid and Colchicine Actavis. Colchicine. Colchicine is reported ...
Probenecid with colchicine is a combination medication used to treat gout. Brand names include ColBenemid, Col-Probenecid, and ...
Tell us about your personal experience with Colchicine as a treatment: Has it worked? Have you had any issues? Any ... colchicine has worked to stave off minor attacks but the last attack I had in my ankle it was no use for. not sure what to do ... But since then, and after several crippling attacks, I was put on colchicine daily to help keep full blown from happening. It ... this is my first time on colchicine and its given me fierce diarreaha. any thing else that works , been using indomethacine ...
Colchicine. Colchicine is a medication most commonly used to treat gout. It is a toxic natural product and secondary metabolite ... Cyberbotanica: Colchicine. *^ Wallace Graham; James B. Roberts (1953). "Intravenous colchicine in the treatment of gouty ... Colchicine should not be taken with macrolide antibiotics such as erythromycin or clarithromycin as this may lead to colchicine ... Colchicine can be toxic when ingested, inhaled, or absorbed in the eyes. Colchicine can cause a temporary clouding of the ...
Read more about the prescription drug COLCHICINE - ORAL. ... GENERIC NAME: COLCHICINE - ORAL (KOL-chi-seen). Medication Uses ... Consumer information about the medication COLCHICINE - ORAL, includes side effects, drug interactions, recommended dosages, and ... MISSED DOSE: If you are taking colchicine regularly and miss a dose, take it as soon as you remember. If it is near the time of ... Colchicine works by decreasing swelling and lessening the build up of uric acid crystals that cause pain in the affected joint( ...
Detailed Colchicine dosage information for adults, the elderly and children. Includes dosages for Acute Gout, Gout - ... Gout, Prophylaxis colchicine, Colcrys, Mitigare, More.... Familial Mediterranean Fever colchicine, Colcrys, Ilaris, canakinumab ... Gout, Acute naproxen, ibuprofen, Aleve, Advil, colchicine, Medrol, methylprednisolone, Naprosyn, More.... ... Colchicine Toxicity: Temporary interruption or discontinuation will be necessary. -Gastrointestinal tract adverse effects (e.g ...
  • Colchicine was eventually isolated in 1820 by French chemists and was finally approved by the FDA in 1939. (ecrater.co.uk)
  • Colchicine (Colcrys) is also used to relieve the pain of gout attacks when they occur. (medlineplus.gov)
  • 6 mg, compare the lowest cost Colchicine prices from PharmacyChecker-verified online pharmacies below Colcrys / Colchicine (Colchicine) We affiliate with other dispensaries that ship product to our customers from the following jurisdictions: Canada, Singapore, New Zealand, Turkey, Mauritius, India, and United Kingdom. (liberalconspiracy.org)
  • Colcrys is comprised of the main ingredient colchicine. (liberalconspiracy.org)
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  • Colcrys (colchicine) affects the way the body responds to uric acid crystals, which reduces swelling and pain. (drugs.com)
  • As of 2009, Colcrys is the only brand of colchicine that has been approved by the FDA. (drugs.com)
  • The Colcrys brand of colchicine is FDA-approved to treat gout in adults, and to treat a genetic condition called Familial Mediterranean Fever in adults and children who are at least 4 years old. (drugs.com)
  • You should not use Colcrys if you are allergic to colchicine. (drugs.com)
  • Colchicine, known commonly by its common brand name, Colcrys, is a prescription medication used to treat Gout attacks and/or gout flares. (liberalconspiracy.org)
  • URL Pharma, Inc., announced that the U.S. Food and Drug Administration (FDA) has approved Colcrys(TM) (colchicine, USP) for the prophylaxis (prevention) of gout flares. (medicalnewstoday.com)
  • Colcrys is an oral, branded form of colchicine that has been formulated for optimal efficacy and tolerability. (medicalnewstoday.com)
  • Colcrys provides a formulation with the efficacy of colchicine while avoiding most of the toxicity of the unapproved products historically on the market. (medicalnewstoday.com)
  • Colchicine has been proven to be effective in preventing flares when given in conjunction with uric acid-lowering therapy, and with Colcrys, doctors can now prescribe colchicine with greater confidence. (medicalnewstoday.com)
  • Colcrys is the only FDA-approved single-ingredient oral colchicine product available on the U.S. market. (medicalnewstoday.com)
  • The manufacturer of Colcrys, Mutual Pharmaceutical/URL Pharma, has established a Patient Assistance Program (PAP) and a Co-Pay Assistance Program (CAP) to ensure that all patients will be able to continue affordable access to colchicine. (medicalnewstoday.com)
  • All single-ingredient oral colchicine products, other than Colcrys, that are currently being marketed are unapproved drugs and have never been evaluated by the agency. (medicalnewstoday.com)
  • Colchicine (Brand: Colcrys) is an alkaloid used to prevent or treat gout attacks (flares), and is also used to prevent attacks of pain in the abdomen, chest, or joints caused by a certain inherited disease ( familial Mediterranean fever ). (rxlist.com)
  • Our Colchicine (Brand: Colcrys) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Male Sprague-Dawley-rats were treated with either colchicine at 1.0mg/kg or saline intraperitoneally 30 minutes prior to exposure to phosgene at 0.5 parts per million for 60 minutes and air. (cdc.gov)
  • However, since little difference was seen between the various concentrations of colchicine and the cellularization of the endosperm was still observed in treated cell, this may indicate that either colchicine did not affect the cytoskeleton controlling endosperm development or that it did not successfully penetrate the embryo sacs. (queensu.ca)
  • The species is related to the genus Wurmbea, which is present in southern Africa and Australia, and is known to be a poisonous plant containing the alkaloid colchicine. (wikipedia.org)
  • Thus, a mammalian metabolite of estradiol binds to the colchicine site of tubulin and, depending on reaction conditions, either inhibits assembly or seems to be incorporated into a polymer with altered stability properties. (pnas.org)
  • Ciclosporin inhibits P-glycoprotein should increase colchicine bioavailability whereas tacrolimus should not influence colchicine disposition. (clinicaltrials.gov)
  • Colchicine inhibits elevations in both alveolar-capillary membrane permeability and lavage surfactant after exposure of the rat to phosgene. (cdc.gov)
  • Colchicine inhibits macrophage production of TNFα, leading to the interference between TNFα and neutrophil interaction. (wikipedia.org)
  • Exposure to colchicine can be fatal in very small doses (e.g., 7 to 65 mg). (cdc.gov)
  • AT did not improve after 10, 20, and 30 minutes of exposure to colchicine (10 −5 , 10 −4 , and 10 −3 mol/L) in any group. (ahajournals.org)
  • A suitable exposure to colchicine produced accumulation of metaphase-blocked mitoses after the colchicine was removed from the medium. (rupress.org)
  • We also compared rates of MI per person-year exposure to colchicine, control, lapse, and pooled control and lapse periods, and observed significant differences between colchicine active use vs. lapse ( P =0.02), and vs. lapse and control ( P =0.04). (empr.com)
  • H 3 -colchicine of high specific activity (2.5 curies per m M ) was prepared in order to study the mechanism of colchicine inhibition of mitosis in cultures of human cells, strain K.B. No direct effects on the duration of the cell cycle or macromolecular synthesis were demonstrable at a concentration of colchicine which completely inhibited mitosis. (rupress.org)
  • The high concentration of colchicine in neutrophils, sixteen times greater compared the plasma levels, can account for the positive therapeutic effects. (wikipedia.org)
  • October 3, 2012 (Baltimore, Maryland) - The administration of colchicine in patients who underwent pulmonary vein isolation helps to prevent early recurrences of atrial fibrillation, research shows . (medscape.com)
  • Chronic administration of colchicine is associated with bone marrow suppression, myelosuppression, leukopenia, thrombocytopenia or aplastic anemia. (aocd.org)
  • Chronic administration of colchicine produces atrophy and weakness of the skeletal musculature, apparently due to a peripheral action. (aspetjournals.org)
  • After oral administration of colchicine (8 mg/kg) in the form of either the nanoemulsion or in free colchicine solution, the relative bioavailability of nanoemulsion and eugenol-nanoemulsion were enhanced by about 1.6- and 2.1-fold, respectively, compared with free colchicine solution. (dovepress.com)
  • Colchicine is used to prevent gout attacks (sudden, severe pain in one or more joints caused by abnormally high levels of a substance called uric acid in the blood) in adults. (medlineplus.gov)
  • Some clinical conditions might communicate with colchicine Colchicine works by decreasing the swelling and build-up of uric acid crystals that cause pain in the affected joints - usually the big toe, knee, or ankle joints. (liberalconspiracy.org)
  • Colchicine has been shown to be well-tolerated when paired with uric acid-lowering agents such as allopurinol. (medicalnewstoday.com)
  • During the uric 30 hospitals, the closed polyuria cheap colchicine pills usa needs toward the syndrome middle, and the pressure session is maintained despite the heed in many consequence. (sanfranciscochinatown.com)
  • Many single ingredient oral colchicine products have been used by the medical community for decades. (medicalnewstoday.com)
  • In an editorial accompanying the study , Drs Gregory Marcus and Jonathan Hsu (University of California, San Diego) state that a few more steps are needed before colchicine can be used regularly in clinical practice. (medscape.com)
  • They found that for patients in the colchicine group, the time to clinical deterioration improved, although there were no significant differences between the groups in cardiac and inflammatory biomarkers. (medscape.com)
  • Deftereos and colleagues have studied the effects of colchicine in a variety of clinical settings for the past decade. (medscape.com)
  • Improved time to clinical deterioration "was our prespecified clinical endpoint, as per protocol design, [and] indeed, the clinical endpoint occurred only in 1 of 55 patients in the colchicine group and in 7 of 50 patients in the control group," Deftereos said. (medscape.com)
  • Our clinical research on colchicine - the first of its kind ever conducted -- has brought colchicine manufacturing, dosing, safety and efficacy information into compliance with current FDA standards. (medicalnewstoday.com)
  • We therefore think that large high-quality clinical trials should be conducted to further investigate colchicine in heart disease. (cochrane.org)
  • The clinical use of colchicine is supported by a well-known safety profile, and is available at a very affordable cost as compared to some newer cardiovascular medicines used in similar indications. (yahoo.com)
  • The companies are expected to stop manufacturing single-ingredient oral colchicine within 45 days and must stop shipping this unapproved product in interstate commerce within 90 days. (medicalnewstoday.com)
  • It is a priority for the FDA to get unapproved medications, such as older versions of single ingredient oral colchicine, either updated to conform to FDA's current approval standards or off the market," said Deborah M. Autor, director of CDER's Office of Compliance. (medicalnewstoday.com)
  • The specific aim of this study is to evaluate the effect of oral colchicine in primary TKA patients at 3 months following a manipulation under anesthesia. (clinicaltrials.gov)
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  • However, unapproved colchicine has not been reviewed by the FDA for safety and efficacy. (medicalnewstoday.com)
  • As a result, critical information about unapproved colchicine products -- including safety and efficacy, potential adverse events, drug interactions and manufacturing practices -- cannot be determined. (medicalnewstoday.com)
  • As there are limited medical therapies proven effective to improve obesity-related metabolic dysregulation, we propose to determine the efficacy of colchicine 0.6 mg twice daily in non-diabetic obese adults with metabolic syndrome. (clinicaltrials.gov)
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  • However, general practitioners (GPs) prescribe colchicine infrequently, probably because in the past the recommendation was for high doses to be prescribed which commonly caused severe diarrhoea. (clinicaltrials.gov)
  • Colchicine and dimethyl sulfoxide are most commonly used. (wikipedia.org)
  • Patients are advised to stop taking colchicine immediately if they experience abdominal pain, diarrhoea, nausea or vomiting, or a burning feeling in their throat, stomach or on their skin. (bpac.org.nz)
  • For hand, there is the development of an educated vector who presented to her nausea with a surprising severity of same where can i buy colchicine online uk. (sanfranciscochinatown.com)
  • In contrast, patients treated with colchicine presented a decrease of 28% in hs-CRP levels (p=0.0026). (umontreal.ca)
  • however, diarrhea was more frequent in the colchicine group than in the control group. (medscape.com)
  • Ingestion of colchicine typically leads to profuse vomiting and diarrhea, which can be bloody, followed by hypovolemic shock and multisystem organ failure within 24-72 hours. (cdc.gov)