Catheters, Indwelling: Catheters designed to be left within an organ or passage for an extended period of time.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Catheters: A flexible, tubular device that is used to carry fluids into or from a blood vessel, hollow organ, or body cavity.Blood Vessel Prosthesis: Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.Cardiac Catheters: Catheters inserted into various locations within the heart for diagnostic or therapeutic purposes.Prosthesis Design: The plan and delineation of prostheses in general or a specific prosthesis.Blood Vessel Prosthesis Implantation: Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.Vagus Nerve Stimulation: An adjunctive treatment for PARTIAL EPILEPSY and refractory DEPRESSION that delivers electrical impulses to the brain via the VAGUS NERVE. A battery implanted under the skin supplies the energy.Vagus Nerve: The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Nerve Block: Interruption of NEURAL CONDUCTION in peripheral nerves or nerve trunks by the injection of a local anesthetic agent (e.g., LIDOCAINE; PHENOL; BOTULINUM TOXINS) to manage or treat pain.Phantoms, Imaging: Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)Radio Waves: Electromagnetic waves with frequencies between about 3 kilohertz (very low frequency - VLF) and 300,000 megahertz (extremely high frequency - EHF). They are used in television and radio broadcasting, land and satellite communications systems, radionavigation, radiolocation, and DIATHERMY. The highest frequency radio waves are MICROWAVES.Jewelry: Objects of precious metal usually containing gems and worn to enhance personal appearance. Health concerns include possible contamination from lead content or bacteria.Body Piercing: The perforation of an anatomical region for the wearing of jewelry.Foreign Bodies: Inanimate objects that become enclosed in the body.Spectrometry, X-Ray Emission: The spectrometric analysis of fluorescent X-RAYS, i.e. X-rays emitted after bombarding matter with high energy particles such as PROTONS; ELECTRONS; or higher energy X-rays. Identification of ELEMENTS by this technique is based on the specific type of X-rays that are emitted which are characteristic of the specific elements in the material being analyzed. The characteristic X-rays are distinguished and/or quantified by either wavelength dispersive or energy dispersive methods.Multiple System Atrophy: A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. (From Adams et al., Principles of Neurology, 6th ed, p1076; Baillieres Clin Neurol 1997 Apr;6(1):187-204; Med Clin North Am 1999 Mar;83(2):381-92)Olivopontocerebellar Atrophies: A group of inherited and sporadic disorders which share progressive ataxia in combination with atrophy of the CEREBELLUM; PONS; and inferior olivary nuclei. Additional clinical features may include MUSCLE RIGIDITY; NYSTAGMUS, PATHOLOGIC; RETINAL DEGENERATION; MUSCLE SPASTICITY; DEMENTIA; URINARY INCONTINENCE; and OPHTHALMOPLEGIA. The familial form has an earlier onset (second decade) and may feature spinal cord atrophy. The sporadic form tends to present in the fifth or sixth decade, and is considered a clinical subtype of MULTIPLE SYSTEM ATROPHY. (From Adams et al., Principles of Neurology, 6th ed, p1085)Shy-Drager Syndrome: A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)Supranuclear Palsy, Progressive: A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)alpha-Synuclein: A synuclein that is a major component of LEWY BODIES that plays a role in neurodegeneration and neuroprotection.Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.Genetic Vectors: DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.Muscular Atrophy, Spinal: A group of disorders marked by progressive degeneration of motor neurons in the spinal cord resulting in weakness and muscular atrophy, usually without evidence of injury to the corticospinal tracts. Diseases in this category include Werdnig-Hoffmann disease and later onset SPINAL MUSCULAR ATROPHIES OF CHILDHOOD, most of which are hereditary. (Adams et al., Principles of Neurology, 6th ed, p1089)Lentivirus: A genus of the family RETROVIRIDAE consisting of non-oncogenic retroviruses that produce multi-organ diseases characterized by long incubation periods and persistent infection. Lentiviruses are unique in that they contain open reading frames (ORFs) between the pol and env genes and in the 3' env region. Five serogroups are recognized, reflecting the mammalian hosts with which they are associated. HIV-1 is the type species.Spinal Muscular Atrophies of Childhood: A group of recessively inherited diseases that feature progressive muscular atrophy and hypotonia. They are classified as type I (Werdnig-Hoffman disease), type II (intermediate form), and type III (Kugelberg-Welander disease). Type I is fatal in infancy, type II has a late infantile onset and is associated with survival into the second or third decade. Type III has its onset in childhood, and is slowly progressive. (J Med Genet 1996 Apr:33(4):281-3)SMN Complex Proteins: A complex of proteins that assemble the SNRNP CORE PROTEINS into a core structure that surrounds a highly conserved RNA sequence found in SMALL NUCLEAR RNA. They are found localized in the GEMINI OF COILED BODIES and in the CYTOPLASM. The SMN complex is named after the Survival of Motor Neuron Complex Protein 1, which is a critical component of the complex.Survival of Motor Neuron 1 Protein: A SMN complex protein that is essential for the function of the SMN protein complex. In humans the protein is encoded by a single gene found near the inversion telomere of a large inverted region of CHROMOSOME 5. Mutations in the gene coding for survival of motor neuron 1 protein may result in SPINAL MUSCULAR ATROPHIES OF CHILDHOOD.Transduction, Genetic: The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.Polar Bodies: Minute cells produced during development of an OOCYTE as it undergoes MEIOSIS. A polar body contains one of the nuclei derived from the first or second meiotic CELL DIVISION. Polar bodies have practically no CYTOPLASM. They are eventually discarded by the oocyte. (from King & Stansfield, A Dictionary of Genetics, 4th ed)Transducers: Any device or element which converts an input signal into an output signal of a different form. Examples include the microphone, phonographic pickup, loudspeaker, barometer, photoelectric cell, automobile horn, doorbell, and underwater sound transducer. (McGraw Hill Dictionary of Scientific and Technical Terms, 4th ed)Equipment Design: Methods of creating machines and devices.Ion Channels: Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.Magnetics: The study of MAGNETIC PHENOMENA.Equipment Failure Analysis: The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.Ribonucleoproteins, Small Nucleolar: Nucleolar RNA-protein complexes that function in pre-ribosomal RNA processing.PseudouridineRibonucleoproteins, Small Nuclear: Highly conserved nuclear RNA-protein complexes that function in RNA processing in the nucleus, including pre-mRNA splicing and pre-mRNA 3'-end processing in the nucleoplasm, and pre-rRNA processing in the nucleolus (see RIBONUCLEOPROTEINS, SMALL NUCLEOLAR).RNA, Small Nucleolar: Small nuclear RNAs that are involved in the processing of pre-ribosomal RNA in the nucleolus. Box C/D containing snoRNAs (U14, U15, U16, U20, U21 and U24-U63) direct site-specific methylation of various ribose moieties. Box H/ACA containing snoRNAs (E2, E3, U19, U23, and U64-U72) direct the conversion of specific uridines to pseudouridine. Site-specific cleavages resulting in the mature ribosomal RNAs are directed by snoRNAs U3, U8, U14, U22 and the snoRNA components of RNase MRP and RNase P.Telomerase: An essential ribonucleoprotein reverse transcriptase that adds telomeric DNA to the ends of eukaryotic CHROMOSOMES.Dyskeratosis Congenita: A predominantly X-linked recessive syndrome characterized by a triad of reticular skin pigmentation, nail dystrophy and leukoplakia of mucous membranes. Oral and dental abnormalities may also be present. Complications are a predisposition to malignancy and bone marrow involvement with pancytopenia. (from Int J Paediatr Dent 2000 Dec;10(4):328-34) The X-linked form is also known as Zinsser-Cole-Engman syndrome and involves the gene which encodes a highly conserved protein called dyskerin.Ribonucleoproteins: Complexes of RNA-binding proteins with ribonucleic acids (RNA).Music: Sound that expresses emotion through rhythm, melody, and harmony.Sound: A type of non-ionizing radiation in which energy is transmitted through solid, liquid, or gas as compression waves. Sound (acoustic or sonic) radiation with frequencies above the audible range is classified as ultrasonic. Sound radiation below the audible range is classified as infrasonic.Music Therapy: The use of music as an adjunctive therapy in the treatment of neurological, mental, or behavioral disorders.Heart: The hollow, muscular organ that maintains the circulation of the blood.ArtSound Localization: Ability to determine the specific location of a sound source.Heart Rate: The number of times the HEART VENTRICLES contract per unit of time, usually per minute.

Newly assembled snRNPs associate with coiled bodies before speckles, suggesting a nuclear snRNP maturation pathway. (1/196)

BACKGROUND: Small nuclear ribonucleoproteins (snRNPs), which are essential components of the mRNA splicing machinery, comprise small nuclear RNAs, each complexed with a set of proteins. An early event in the maturation of snRNPs is the binding of the core proteins - the Sm proteins - to snRNAs in the cytoplasm followed by nuclear import. Immunolabelling with antibodies against Sm proteins shows that splicing snRNPs have a complex steady-state localisation within the nucleus, the result of the association of snRNPs with several distinct subnuclear structures. These include speckles, coiled bodies and nucleoli, in addition to a diffuse nucleoplasmic compartment. The reasons for snRNP accumulation in these different structures are unclear. RESULTS: When mammalian cells were microinjected with plasmids encoding the Sm proteins B, D1 and E, each tagged with either the green fluorescent protein (GFP) or yellow-shifted GFP (YFP), a pulse of expression of the tagged proteins was observed. In each case, the newly synthesised GFP/YFP-labelled snRNPs accumulated first in coiled bodies and nucleoli, and later in nuclear speckles. Mature snRNPs localised immediately to speckles upon entering the nucleus after cell division. CONCLUSIONS: The complex nuclear localisation of splicing snRNPs results, at least in part, from a specific pathway for newly assembled snRNPs. The data demonstrate that the distribution of snRNPs between coiled bodies and speckles is directed and not random.  (+info)

Interactions of U2 gene loci and their nuclear transcripts with Cajal (coiled) bodies: evidence for PreU2 within Cajal bodies. (2/196)

The Cajal (coiled) body (CB) is a structure enriched in proteins involved in mRNA, rRNA, and snRNA metabolism. CBs have been shown to interact with specific histone and snRNA gene loci. To examine the potential role of CBs in U2 snRNA metabolism, we used a variety of genomic and oligonucleotide probes to visualize in situ newly synthesized U2 snRNA relative to U2 loci and CBs. Results demonstrate that long spacer sequences between U2 coding repeats are transcribed, supporting other recent evidence that U2 transcription proceeds past the 3' box. The presence of bright foci of this U2 locus RNA differed between alleles within the same nucleus; however, this did not correlate with the loci's association with a CB. Experiments with specific oligonucleotide probes revealed signal for preU2 RNA within CBs. PreU2 was also detected in the locus-associated RNA foci, whereas sequences 3' of preU2 were found only in these foci, not in CBs. This suggests that a longer primary transcript is processed before entry into CBs. Although this work shows that direct contact of a U2 locus with a CB is not simply correlated with RNA at that locus, it provides the first evidence of new preU2 transcripts within CBs. We also show that, in contrast to CBs, SMN gems do not associate with U2 gene loci and do not contain preU2. Because other evidence indicates that preU2 is processed in the cytoplasm before assembly into snRNPs, results point to an involvement of CBs in modification or transport of preU2 RNA.  (+info)

Characterization of the nucleolar gene product, treacle, in Treacher Collins syndrome. (3/196)

Treacher Collins syndrome (TCS) is an autosomal dominant disorder of craniofacial development caused by mutations in the gene TCOF1. Its gene product, treacle, consists mainly of a central repeat domain, which shows it to be structurally related to the nucleolar phosphoprotein Nopp140. Treacle remains mostly uncharacterized to date. Herein we show that it, like Nopp140, is a highly phosphorylated nucleolar protein. However, treacle fails to colocalize with Nopp140 to Cajal (coiled) bodies. As in the case of Nopp140, casein kinase 2 appears to be responsible for the unusually high degree of phosphorylation as evidenced by its coimmunoprecipitation with treacle. Based on these and other observations, treacle and Nopp140 exhibit distinct but overlapping functions. The majority of TCOF1 mutations in TCS lead to premature termination codons that could affect the cellular levels of the full-length treacle. We demonstrate however, that the cellular amount of treacle varies less than twofold among a collection of primary fibroblasts and lymphoblasts and regardless of whether the cells were derived from TCS patients or healthy individuals. Therefore, cells of TCS patients possess a mechanism to maintain wild-type levels of full-length treacle from a single allele.  (+info)

Cell cycle-regulated phosphorylation of p220(NPAT) by cyclin E/Cdk2 in Cajal bodies promotes histone gene transcription. (4/196)

Cyclin E/Cdk2 acts at the G1/S-phase transition to promote the E2F transcriptional program and the initiation of DNA synthesis. To explore further how cyclin E/Cdk2 controls S-phase events, we examined the subcellular localization of the cyclin E/Cdk2 interacting protein p220(NPAT) and its regulation by phosphorylation. p220 is localized to discrete nuclear foci. Diploid fibroblasts in Go and G1 contain two p220 foci, whereas S- and G2-phase cells contain primarily four p220 foci. Cells in metaphase and telophase have no detectable focus. p220 foci contain cyclin E and are coincident with Cajal bodies (CBs), subnuclear organelles that associate with histone gene clusters on chromosomes 1 and 6. Interestingly, p220 foci associate with chromosome 6 throughout the cell cycle and with chromosome 1 during S phase. Five cyclin E/Cdk2 phosphorylation sites in p220 were identified. Phospho-specific antibodies against two of these sites react with p220 within CBs in a cell cycle-specific manner. The timing of p220 phosphorylation correlates with the appearance of cyclin E in CBs at the G1/S boundary, and this phosphorylation is maintained until prophase. Expression of p220 activates transcription of the histone H2B promoter. Importantly, mutation of Cdk2 phosphorylation sites to alanine abrogates the ability of p220 to activate the histone H2B promoter. Collectively, these results strongly suggest that p220(NPAT) links cyclical cyclin E/Cdk2 kinase activity to replication-dependent histone gene transcription.  (+info)

Mutational analysis of fibrillarin and its mobility in living human cells. (5/196)

Cajal bodies (CBs) are subnuclear organelles that contain components of a number of distinct pathways in RNA transcription and RNA processing. CBs have been linked to other subnuclear organelles such as nucleoli, but the reason for the presence of nucleolar proteins such as fibrillarin in CBs remains uncertain. Here, we use full-length fibrillarin and truncated fibrillarin mutants fused to green fluorescent protein (GFP) to demonstrate that specific structural domains of fibrillarin are required for correct intranuclear localization of fibrillarin to nucleoli and CBs. The second spacer domain and carboxy terminal alpha-helix domain in particular appear to target fibrillarin, respectively, to the nucleolar transcription centers and CBs. The presence of the RNP domain seems to be a prerequisite for correct targeting of fibrillarin. Time-lapse confocal microscopy of human cells that stably express fibrillarin-GFP shows that CBs fuse and split, albeit at low frequencies. Recovered fluorescence of fibrillarin-GFP in nucleoli and CBs after photobleaching indicates that it is highly mobile in both organelles (estimated diffusion constant approximately 0.02 microm(2) s(-1)), and has a significantly larger mobile fraction in CBs than in nucleoli.  (+info)

Self-association of coilin reveals a common theme in nuclear body localization. (6/196)

We have found that coilin, the marker protein for Cajal bodies (coiled bodies, CBs), is a self-interacting protein, and we have mapped the domain responsible for this activity to the amino-terminus. Together with a nuclear localization signal, the self-interaction domain is necessary and sufficient for localization to CBs. Overexpression of various wild-type and mutant coilin constructs in HeLa cells results in disruption of both CBs and survival motor neurons (SMN) gems. Additionally, we have identified a cryptic nucleolar localization signal (NoLS), within the coilin protein, which may be exposed in specific coilin phospho-isoforms. The implications of these findings are discussed in light of the fact that other proteins known to localize within nuclear bodies (e. g., PML, SMN and Sam68) can also self-associate. Thus protein self-interaction appears to be a general feature of nuclear body marker proteins.  (+info)

In vivo analysis of Cajal body movement, separation, and joining in live human cells. (7/196)

Cajal bodies (also known as coiled bodies) are subnuclear organelles that contain specific nuclear antigens, including splicing small nuclear ribonucleoproteins (snRNPs) and a subset of nucleolar proteins. Cajal bodies are localized in the nucleoplasm and are often found at the nucleolar periphery. We have constructed a stable HeLa cell line, HeLa(GFP-coilin), that expresses the Cajal body marker protein, p80 coilin, fused to the green fluorescent protein (GFP-coilin). The localization pattern and biochemical properties of the GFP-coilin fusion protein are identical to the endogenous p80 coilin. Time-lapse recordings on 63 nuclei of HeLa(GFP-coilin) cells showed that all Cajal bodies move within the nucleoplasm. Movements included translocations through the nucleoplasm, joining of bodies to form larger structures, and separation of smaller bodies from larger Cajal bodies. Also, we observed Cajal bodies moving to and from nucleoli. The data suggest that there may be at least two classes of Cajal bodies that differ in their size, antigen composition, and dynamic behavior. The smaller size class shows more frequent and faster rates of movement, up to 0.9 microm/min. The GFP-coilin protein is dynamically associated with Cajal bodies as shown by changes in their fluorescence intensity over time. This study reveals an unexpectedly high level of movement and interactions of nuclear bodies in human cells and suggests that these movements may be driven, at least in part, by regulated mechanisms.  (+info)

Replication-dependent histone gene expression is related to Cajal body (CB) association but does not require sustained CB contact. (8/196)

Interactions between Cajal bodies (CBs) and replication-dependent histone loci occur more frequently than for other mRNA-encoding genes, but such interactions are not seen with all alleles at a given time. Because CBs contain factors required for transcriptional regulation and 3' end processing of nonpolyadenylated replication-dependent histone transcripts, we investigated whether interaction with CBs is related to metabolism of these transcripts, known to vary during the cell cycle. Our experiments revealed that a locus containing a cell cycle-independent, replacement histone gene that produces polyadenylated transcripts does not preferentially associate with CBs. Furthermore, modest but significant changes in association levels of CBs with replication-dependent histone loci mimic their cell cycle modulations in transcription and 3' end processing rates. By simultaneously visualizing replication-dependent histone genes and their nuclear transcripts for the first time, we surprisingly find that the vast majority of loci producing detectable RNA foci do not contact CBs. These studies suggest some link between CB association and unusual features of replication-dependent histone gene expression. However, sustained CB contact is not a requirement for their expression, consistent with our observations of U7 snRNP distributions. The modest correlation to gene expression instead may reflect transient gene signaling or the nucleation of small CBs at gene loci.  (+info)

*Talk:Mind-body dualism

... www.a-c-elitzur.co.il/site/siteArticle.asp?ar=67 I present a new argument for dualism named "The Bafflement Argument." It is ... There need not be a strict soul/body or mind/body dualism in order for there to be a soul that has knowledge of the forms. In ... For instance, the spleen is undeniably part of the body and not part of the mind. If "the mind is not contained by the body" is ... It does not follow that though brain imaging devices observe causal-relative activities between mind and body, that mind-body ...

*Snurposome

Cajal Bodies (Coiled Bodies) and Transcriptosomes". Molecular Biology of the Cell. 10 (12): 4385-4402. doi:10.1091/mbc.10.12. ... ISBN 3-662-22325-2. Wu, Z; Murphy, C; Wu, C. H.; Tsvetkov, A; Gall, J. G. (1993). "Snurposomes and coiled bodies". Cold Spring ...

*Greater black krait

When disturbed, it coils loosely and hides its head beneath its body; it is reluctant to bite except upon persistent ...

*Gastro-

They are distinguished by torsion, a process where the body coils to one side during development. Gastrotheca (marsupial frogs ... The body is covered with cilia, especially about the mouth, and has two terminal projections that serve as adhesive tubes. Like ... and that these results occur naturally in the body through a similar hormone, secretin. It is now believed that the function of ...

*Nucleolar phosphoprotein p130

Isaac C, Yang Y, Meier UT (1998). "Nopp140 functions as a molecular link between the nucleolus and the coiled bodies". J. Cell ... "Entrez Gene: NOLC1 nucleolar and coiled-body phosphoprotein 1". Isaac, C; Yang Y; Meier U T (Jul 1998). "Nopp140 functions as a ... molecular link between the nucleolus and the coiled bodies". J. Cell Biol. UNITED STATES. 142 (2): 319-29. doi:10.1083/jcb. ...

*U7 small nuclear RNA

Wu CH, Murphy C, Gall JG (1996). "The Sm binding site targets U7 snRNA to coiled bodies (spheres) of amphibian oocytes". RNA. 2 ... Jacobs EY, Frey MR, Wu W, Ingledue TC, Gebuhr TC, Gao L, Marzluff WF, Matera AG (1999). "Coiled bodies preferentially associate ... Frey MR, Matera AG (1995). "Coiled bodies contain U7 small nuclear RNA and associate with specific DNA sequences in interphase ... Tuma RS, Roth MB (1999). "Induction of coiled body-like structures in Xenopus oocytes by U7 snRNA". Chromosoma. 108 (6): 337- ...

*Coilin

"Assembly of snRNP-containing coiled bodies is regulated in interphase and mitosis--evidence that the coiled body is a kinetic ... "Entrez Gene: COIL coilin". Hong S, Ka S, Kim S, Park Y, Kang S (May 2003). "p80 coilin, a coiled body-specific protein, ... Isaac C, Yang Y, Meier UT (Jul 1998). "Nopp140 functions as a molecular link between the nucleolus and the coiled bodies". J. ... Isaac C, Yang Y, Meier UT (1998). "Nopp140 functions as a molecular link between the nucleolus and the coiled bodies". J. Cell ...

*Brave Police J-Decker

Powers include levitation, an electrical body, and a coiling tail. It is an artificial ghost created by illusionist Magi Demon ... It forms the body of J-Decker. Duke Fire (デュークファイヤー, Dyuuku faiyaa) (Voiced by Toshiyuki Morikawa) : The secondary super robot ... He forms the body additions of Fire J-Decker. Duke (デューク, Dyuuku) (Voiced by Toshiyuki Morikawa) : A sentient robot that ... Its only known power is having seven tank cannons on each side of its body. It was constructed from Special Police Units merged ...

*Petalifera

These sea hares swim by coiling and uncoiling the body. Petalifera albomaculata Farran, 1905 - Sri Lanka. Petalifera habei ... Description : rather flat body; their color camouflages them when they are grazing on the brown alga Padina. Petalifera ... Length : 5 to 7 cm Color : pink to pale brownish, with white rings over the body; almost translucent. Description : mantle ...

*Fay Bound Alberti

ISBN 978-0-19-160917-6. This Mortal Coil: The Human Body in History and Culture. Oxford University Press. 2016. ISBN 978-0-19- ... and This Mortal Coil: The Human Body in History and Culture (2016). Matters of the Heart was shortlisted for the Longman ... Alberti appeared on BBC Radio 3's Free Thinking to discuss This Mortal Coil in 2016 and on BBC Radio 4's In Our Time to discuss ... "The Enduring Mystery of the Human Body". The Spectator. Retrieved 12 April 2017. "Shortlist for Longman - History Today Book of ...

*Black-bellied slender salamander

This species will coil its body and tail when handled; it is fragile and easily injured. Batrachoseps nigriventis looks similar ... It has a worm-like body, a small head and small limbs, and a long cylindrical tail, often twice the length of its body. The ...

*Cat Paradise

She also has a younger brother; another snake who coils and drapes around her human body. The two are able to hypnotize others ... Unlike the others, he freely prefers to stay in a half-transformed state, giving his animal head and limbs to a human body. It ... Sakira (沙姫羅, Sakira) The last of Kaen's subordinates to be met, she is a snake spirit beast that possesses the body of a ... He took over the body of the vice-principal so he may freely move about the academy. Rachi (螺蜘, Rachi) One of Tsukumoishu's ...

*Perrottetia hongthinhae

Subsequent whorls are regularly coiled. Body whorl is axially deflected. The aperture is rectangular with rounded angles. ... Compared to Perrottetia messageri, the Perrottetia hongthinhae has a smaller shell with weak transverse ridges, and the body ...

*Infrared heater

This wire was then coiled into a spiral and wrapped around a ceramic body. When heated to high temperatures it forms a ... An infrared heater or heat lamp is a body with a higher temperature which transfers energy to a body with a lower temperature ... No contact or medium between the two bodies is needed for the energy transfer. Infrared heaters can be operated in vacuum or ... As absorption and emission are based on the same physical causes in each body, ceramic is ideally suited as a material for ...

*Triumph 2000

The monocoque body had independent suspension all-round using coil springs. The servo-assisted brakes were disc at the front ... The estate, its body shell partly built by Carbodies, was in the Mk 1 version the same length as the saloon. Various minor ...

*Penis

The clockwise coils are significant because the male phallus everts out of their body in a counter-clockwise spiral; therefore ... The phallus that male waterfowl have evolved everts out of their bodies (in a clockwise coil) and aids in inseminating females ... The urethra is on the ventral side of the body of the penis. As a general rule, a mammal's penis is proportional to its body ... made up of two nervous Bodies, the Channel, Nut, Skin, and Fore-skin, etc." As with nearly any aspect of the body involved in ...

*Cell nucleus

Cajal bodies and gems. A nucleus typically contains between 1 and 10 compact structures called Cajal bodies or coiled bodies ( ... PML bodies. Promyelocytic leukemia bodies (PML bodies) are spherical bodies found scattered throughout the nucleoplasm, ... Matera AG (August 1998). "Of coiled bodies, gems, and salmon". Journal of Cellular Biochemistry. 70 (2): 181-92. doi:10.1002/( ... Similar to Cajal bodies are Gemini of Cajal bodies, or gems, whose name is derived from the Gemini constellation in reference ...

*Common krait

When agitated, it will coil up with its head concealed and body flattened, and makes jerky movements. It may also lift its tail ... It often rolls its body into a loose, coiled ball, keeping its head well concealed. When in this 'balled' condition, the snake ... The body is cylindrical, tapering towards the tail. The tail is short and rounded. The eyes are rather small, with rounded ...

*Mehen (game)

In Egypt, the gameboard depicts a coiled snake whose body is divided into rectangular spaces. Several boards have been found ...

*Ataxin 1

Hong S, Ka S, Kim S, Park Y, Kang S (May 2003). "p80 coilin, a coiled body-specific protein, interacts with ataxin-1, the SCA1 ...

*Washburn RR-V Tour Series

The body was available in white with red stripes diagonally across. RR-40 - The top model. Featured a triple coil humbucker, ... RR-2 - Featured an Alnico split coil humbucker, 2 single coil pick ups, 3 individual pickup selectors and Grover machine heads ... The body was available in either solid white or red with black stripes painted diagonally across. RR-12 - Similar to the RR-11 ... The body was available in one solid colour, most commonly black. RR-11 - Featured upgraded Washburn branded EMG pick ups. ...

*Oregon slender salamander

When found this species will coil its body up and remain motionless. Geoffrey Hammerson; Bruce Bury (2004). "Batrachoseps ... They have a long thin body and grow to 61 mm (2.4 in) in snout-vent length and 120 mm (4.7 in) in total length, though most ...

*Christopher J. Hardy

November 2008). "128-channel body MRI with a flexible high-density receiver-coil array". Journal of Magnetic Resonance Imaging ... November 2008). "128-channel body MRI with a flexible high-density receiver-coil array". Journal of Magnetic Resonance Imaging ... Hardy CJ, Cline HE, Giaquinto RO, Niendorf T, Grant AK, Sodickson DK (May 2006). "32-element receiver-coil array for cardiac ... October 2004). "Highly parallel volumetric imaging with a 32-element RF coil array". Magnetic Resonance in Medicine. 52 (4): ...

*Charlie Pasarell

The toss was accurate, the body coiled, the delivery powerful and adept at hitting all corners. Says the man he partnered with ...

*Anguillicoloides papernai

Its body is spirally coiled and darkly coloured (due to eel blood inside the nematode's intestine). It is fusiform, tapering to ... The entire anterior narrowed part of its body is approximately twice as long as the oesophagus. Four dorso- and ventro-lateral ... The length of the male body is 12.99 millimetres (0.511 in); in females it ranges between 15.78 and 28.29 millimetres (0.621 ... The cuticle of the anterior and posterior parts of its body bear several papilla-like excrescences of a fibrous structured. Its ...

*Magnetic cartridge

The cartridge consists of several components: the stylus, cantilever, magnets, coils and body. The stylus is the part that, ... the coils are attached to the stylus, and move within the field of a permanent magnet. The coils are tiny and made from very ... Magnets and coils are stationary while a micro cross moves with the stylus, thereby varying the distances between the arms of ... Coupled to the tonearm, the cartridge body's function is to give the moving parts a stationary platform so that they can track ...

*Medicine

... to the body, which can then be imaged outside the body by a gamma camera or a PET scanner. Each radiopharmaceutical consists of ... Statue of Asclepius, the Greek god of medicine, holding the symbolic Rod of Asclepius with its coiled serpent ... Diagnostic radiology is concerned with imaging of the body, e.g. by x-rays, x-ray computed tomography, ultrasonography, and ... Folk medicine consists of the healing practices and ideas of body physiology and health preservation known to some in a culture ...

*Bungarus

They are actually rather timid, and will often hide their heads within their coiled bodies for protection. When in this posture ... These phases may not be seen in all parts of the body at the same time. Since kraits are nocturnal, they seldom encounter ...
Cajal bodies (CBs) are nuclear organelles that occur in a variety of organisms, including vertebrates, insects, and plants. They are most often identified with antibodies against the marker protein coilin. Because the amino acid sequence of coilin is not strongly conserved evolutionarily, coilin orthologues have been difficult to recognize by homology search. Here, we report the identification of Drosophila melanogaster coilin and describe its distribution in tissues of the fly. Surprisingly, we found coilin not only in CBs but also in histone locus bodies (HLBs), calling into question the use of coilin as an exclusive marker for CBs. We analyzed two null mutants in the coilin gene and a piggyBac insertion mutant, which leads to specific loss of coilin from the germline. All three mutants are homozygous viable and fertile. Cells that lack coilin also lack distinct foci of other CB markers, including fibrillarin, the survival motor neuron (SMN) protein, U2 small nuclear RNA (snRNA), U5 snRNA, and the
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Cajal bodies (CBs) are subnuclear domains that participate in spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesis and play a part in the assembly of the spliceosomal complex. The CB marker
Reaktivität: Rind (Kuh), Hund, Meerschweinchen and more. 54 verschiedene GEMIN4 Antikörper vergleichen. Alle direkt auf antikörper-online bestellbar!
Fibrillarin is thought to shuttle between the nucleolus and the cytoplasm of complicated Cajal bodies (CBs) and interchromatin granule clusters (IGCs) in oocytes , shared with a COOH-terminal P40 capsid protein encoded with HSV1. The coiled body is a nuclear organelle that contains snRNPs involved in splicing, in both animal and plant cells can undergo…
Complete information for GEMIN5 gene (Protein Coding), Gem Nuclear Organelle Associated Protein 5, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for GEMIN8 gene (Protein Coding), Gem Nuclear Organelle Associated Protein 8, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Overwhelming evidence indicates that aspirin and related non-steroidal anti-inflammatory drugs (NSAIDs) have anti-tumour activity and the potential to prevent cancer, particularly colorectal cancer. However, the mechanisms underlying this effect remain hypothetical. Dysregulation of the nuclear factor-kappaB (NF-κB) transcription factor is a common event in many cancer types which contributes to tumour initiation and progression by driving expression of pro-proliferative/anti-apoptotic genes. In this review, we will focus on the current knowledge regarding NSAID effects on the NF-κB signalling pathway in pre-cancerous and cancerous lesions, and the evidence that these effects contribute to the anti-tumour activity of the agents. The nuclear organelle, the nucleolus, is emerging as a central regulator of transcription factor activity and cell growth and death. Nucleolar function is dysregulated in the majority of cancers which promotes cancer growth through direct and indirect mechanisms. Hence, this
Nuclear autoantigen Sp-100; Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed-11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed-15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through intera [...] (885 aa ...
Coilin小鼠单克隆抗体[IH10](ab87913)可与人样本反应并经WB, IP, IHC, Flow Cyt, ICC/IF实验严格验证,被3篇文献引用并得到1个独立的用户反馈。
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Confocal microscopy and in situ hybridization procedures have led to enormous progress in the visualization of the spatial organization and dynamics of transcription and RNA‐processing machinery in eukaryotic cells. It is well established that the nucleus is a highly organized structure composed of many different territories, subdomains and organelles (Lamond and Earnshaw, 1998). A state‐of‐the‐art account of the nuclear architecture of plant cells was given by P.Shaw (John Innes Centre, Norwich, UK). Mapping of the RNA polymerase I transcription and rRNA processing sites, using different pre‐rRNA, snoRNA and nucleolar protein probes, indicates that the plant cell nucleolus is organized as a series of concentric layers in which transcription and successive rRNA processing reactions occur. As in vertebrate cells, plant cells contain coiled bodies (CBs), nuclear organelles of still poorly defined function. Since CB components include several small RNAs, and also proteins related to ...
Individuals with intellectual disability (ID) often engage in behaviours that are labelled as challenging (challenging behaviours; CB). CBs are actions that may place the individual at risk of harm or exclusion, or may place other people (e.g. carers) at risk of harm [1]. Thus, CBs are defined socially, in terms of their impact. Behaviours labelled as challenging typically include actions such as anger and aggression, self-injurious behaviours (e.g. self-biting, hitting body parts against objects, scratching and gouging), destruction of property, and inappropriate or risky social behaviour. CBs are, by definition, a significant challenge for services and impact negatively on the quality of life of people with ID. CBs are also related to risk of abusive practices (cf. Winterbourne View scandal exposed by BBC Panorama), increased carer stress [2, 3], and high cost of support services [4]. High quality epidemiological research suggests that 18-19% of adults with ID known to services engage in CB ...
This work combines (i) an siRNA‐based biochemical analysis of RNA and protein constituents of the tri‐snRNP in vivo with (ii) the use of fluorescence microscopy to locate these constituents in the nucleus. Our initial finding is that when the cells are depleted of hPrp31 or hPrp6 protein by RNAi knockdown, the formation of U4/U6.U5 tri‐snRNP is inhibited, and stable U4/U6 di‐snRNPs and U5 snRNPs accumulate in the cell (Figure 2). This demonstrates for the first time in vivo that the U4/U6 protein hPrp31 is essential for the interaction of the U4/U6 di‐snRNP with the 20S U5 snRNP, and is consistent with previous studies performed in vitro (Makarova et al, 2002). A similar property must also now be ascribed to the U5 protein hPrp6 which, like the hPrp31 protein, is essential for the stability of the tri‐snRNP in vivo. It is known from two‐hybrid analyses that hPrp31 and hPrp6 bind strongly and specifically to one another (Makarova et al, 2002), and we therefore consider it likely ...
2010 Velma V., Carrero Z., Cosman M., Hebert M.D. Coilin interacts with Ku proteins and inhibits in vitro non-homologous DNA end joining. FEBS Lett. 2010 Dec 1;584(23):4735-9. Epub 2010 Nov 9.PMID: 21070772 [5] Hebert MD. Phosphorylation and the Cajal body: modification in search of function. Arch Biochem Biophys. 2010 Apr 15;496(2):69-76. Epub 2010 Mar 1. Review. PubMed PMID: 20193656; PubMed Central PMCID: PMC2850958. ...
Ageing is an obvious process, which is not under our control, but we all want to prevent it. There are various body components, which act as anti-ageing agents, but their underproduction may lead to early aging. Human body is quite intricate with various balanced and complex chemical reactions that sustain life and growth. Here, we have discussed some of the changes that...
1. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017;67:7-30 2. Schmoll HJ, Van Cutsem E, Stein A. et al. ESMO Consensus Guidelines for management of patients with colon and rectal cancer. a personalized approach to clinical decision making. Ann Oncol. 2012;23:2479-516 3. Taft RJ, Pang KC, Mercer TR. et al. Non-coding RNAs: regulators of disease. J Pathol. 2010;220:126-39 4. Ambros V. The functions of animal microRNAs. Nature. 2004;431:350-5 5. Cavaille J, Nicoloso M, Bachellerie JP. Targeted ribose methylation of RNA in vivo directed by tailored antisense RNA guides. Nature. 1996;383:732-5 6. Ganot P, Bortolin ML, Kiss T. Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs. Cell. 1997;89:799-809 7. Ender C, Krek A, Friedlander MR. et al. A human snoRNA with microRNA-like functions. Mol Cell. 2008;32:519-28 8. Darzacq X, Jady BE, Verheggen C. et al. Cajal body-specific small nuclear RNAs: a novel class of 2-O-methylation and ...
When thio-T was added to GVs isolated from stage V or VI oocytes staining was essentially instantaneous (Movie 1). Both the pattern and number of amyloid-positive particles detected replicated the results seen with sectioned ovary (Fig. 2B, Fig. 1). GVs contain an actin-rich meshwork and numerous non-membrane bound multi-protein complexes associated with critical cellular processes (Feric and Brangwynne, 2013; Handwerger et al., 2005; Kiseleva et al., 2004; Mao et al., 2011; Mohamad and Boden, 2010). These complexes include: nucleoli, where RNA polymerase I transcribes and processes the RNA encoded by rRNA genes; nuclear speckles, that serve as centers for mRNA processing (Spector and Lamond, 2011); histone locus bodies, that are involved in the transcription and processing of histone gene mRNA by RNA polymerase II; and pearls, that coordinate RNA polymerase III transcription (Nizami and Gall, 2012). These particles can be identified by characteristic size, morphology, and the presence of ...
Looking for online definition of Cajal cells in the Medical Dictionary? Cajal cells explanation free. What is Cajal cells? Meaning of Cajal cells medical term. What does Cajal cells mean?
Looking for online definition of black treacle in the Medical Dictionary? black treacle explanation free. What is black treacle? Meaning of black treacle medical term. What does black treacle mean?
Over time, the approach to cerebral palsy management has shifted away from narrow attempts to fix individual physical problems - such as spasticity in a particular limb - to making such treatments part of a larger goal of maximizing the persons independence and community engagement. Much of childhood therapy is aimed at improving gait and walking. Approximately 60% of people with CP are able to walk independently or with aids at adulthood. However, the evidence base for the effectiveness of intervention programs reflecting the philosophy of independence has not yet caught up: effective interventions for body structures and functions have a strong evidence base, but evidence is lacking for effective interventions targeted toward participation, environment, or personal factors. There is also no good evidence to show that an intervention that is effective at the body-specific level will result in an improvement at the activity level, or vice versa. Although such cross-over benefit might happen, ...
Executives at top TV Networks ABC and CBS are said to be "upset" over A&E "caving in" to "Duck Dynasty" supporters and reinstating Phil Robertson to the show, after it had earlier suspended him for comments he made about homosexuality in GQ magazine.
So here are a few of my favourite things. Your author with what turns out to be a fake bull today --- And then theres the tren ...
Gemin 4兔多克隆抗体(ab70750)可与人样本反应并经WB, IP, IHC实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
how to be a gentleman on cbs - TheFutonCritic.com has how to be a gentleman news, listings, dvds, episode guides and more for how to be a gentleman
Phase transitions are found everywhere in nature, and I am interested in understanding how living cells harness them to generate chemically distinct subcellular environments. Whereas 2D phase transitions are thought to organise the membranes that encapsulate organelles such as lysosomes, endosomes, and the endoplasmic reticulum, 3D liquid-liquid phase transitions produce membraneless organelles such as nucleoli, Cajal bodies, P-granules and nuage. These membraneless organelles behave as tiny liquid droplets suspended inside the cell, and can rapidly condense and dissolve with changes in the cell-cycle, or in response to stresses such as viral infection. I am particularly interested in uncovering the molecular details of how membraneless organelles are formed in cells, and in how the unique solvent environment of their interior influences biochemical reactions.. ...
Gastrointestinal (GI) motility function and its regulation is a complex process involving collaboration and communication of multiple cell types such as enteric neurons, interstitial cells of Cajal (ICC), and smooth muscle cells. Recent advances in G
Classic Industries offers a wide selection of 1967 Chevrolet Camaro parts, including 1967 Chevrolet Camaro interior parts and soft trim, 1967 Chevrolet Camaro exterior sheet metal, 1967 Chevrolet Camaro moldings, 1967 Chevrolet Camaro emblems, 1967 Chevrolet Camaro weatherstrip and unique accessories, to nearly every nut and bolt needed for installation.
Damn! When I read this videos description was how to give your possum a proper massage, I thought it was a porn video. Fooled again; but it is an unintentionally hilarious video. Tip: Dont forget to lubricate your possums tail from the base to the tip with slow steady strokes 3-4 times a week.
Hey, Fellow Emailers: Prepare to be offended. But if you got this its because I think you can take it. There are NO SACRED COWS. Some are friends. Some are relatives, some are acquaintances. Some are getting this because youve done one of the things listed below and I know you know better. Others because…
Centrin, a 20-kD phosphoprotein with four calcium-binding EF-hands, is present in the centrosome/basal body apparatus of the green alga Chlamydomonas reinhardtii in three distinct locations: the nucleus-basal body connectors, the distal striated fibers, and the flagellar transition regions. In each location, centrin is found in fibrous structures that display calcium-mediated contraction. The mutant vfl2 has structural defects at all of these locations and is defective for basal body localization and/or segregation. We show that the vfl2 mutation is a G-to-A transition in the centrin structural gene which converts a glutamic acid to a lysine at position 101, the first amino acid of the E-helix of the proteins third EF-hand. This proves that centrin is required to construct the nucleus-basal body connectors, the distal striated fibers, and the flagellar transition regions, and it demonstrates the importance of amino acid 101 to normal centrin function. Based on immunofluorescence analysis using ...
Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:21081503, PubMed:18984161). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. May also indirectly participate in cellular volume control by activation
Treacle and Ink, for those of you who dont know, is a reference to Lewis Carrolls Alice in Wonderland. To be a bit more specific, it actually comes from Through the Looking-Glass. One of my favorite movies when I was a child was the 1985 two-part made for TV version, of both Alice in Wonderland…
The renewal of the Cajal Institute. In late 1969 and early 1970 the traditional fields of Anatomy, Physiology and Psychiatry, among other disciplines related to the study of the brain and its diseases, experienced an unprecedented growth that resulted in the emergence of a new science that was made known under the name of Neuroscience. This new discipline was consolidated mainly due to the advances of molecular biology, electrophysiology, pharmacology and pathology among others. The study of the nervous system became a multidisciplinary task encompassing how many specialties that could be used to understand the functioning of the brain. A good example of this was the creation and development of societies and associations that proliferated in practically all countries interested in the cultivation of Neurobiology. The scientific literature was not far behind, and just as in the early 1960s it was difficult to find beyond half a dozen major journals where to publish Neurobiology (perhaps a couple ...
The common name in the UK for molasses. Treacle is the dark sticky sweet goo that results from the boiled-down sugar cane juice left after the process o...
I recognise that I am unlikely specifically to have included all possible current or future treatments for whatever health condition may lead to the applicability of this AD. Nonetheless I wish to refuse them. Furthermore I am unable to anticipate all possible circumstances under which this AD might become applicable but believe that any such circumstances would be extremely unlikely to alter my decision had I anticipated them. I am very anxious that new treatments or unpredictable circumstances might be used by my healthcare team to argue that this AD is not applicable and not binding. I wish so far as I can to pre-empt any such arguments ...
The monoclonal antibody 414 is an excellent marker for NCSs. However, only a subset of the nucleoporins recognized by this antibody resides in NCSs: Nup153 and Nup62. Similarly, only some inner nuclear membrane (emerin) and lamina proteins (lamin A/C) are enriched in NCSs, whereas all tested proteins of the smooth endoplasmic reticulum are present. This selective composition of the NCS, together with its membrane tubules in the normally membrane-free nucleus, renders the NCS unique among nuclear organelles. Despite the analysis of only a sample of envelope proteins, it is clear that NCSs are not a mere extension but a specialization of the nuclear envelope.. Although membranous structures have been previously observed in nuclei, they were all artificially induced and differ in composition from the physiological NCSs as detailed below. R-rings, which are induced by exogenous expression of the nucleolar protein Nopp140, are virtually indistinguishable from NCSs at an ultrastructural level, hinting ...
Epigenetic alterations are fundamental hallmarks of cancer genomes. We surveyed the landscape of DNA methylation alterations in gastric cancer by analyzing genome-wide CG dinucleotide (CpG) methylation profiles of 240 gastric cancers (203 tumors and 37 cell lines) and 94 matched normal gastric tissues. Cancer-specific epigenetic alterations were observed in 44% of CpGs, comprising both tumor hyper- and hypomethylation. Twenty-five percent of the methylation alterations were significantly associated with changes in tumor gene expression. Whereas most methylation-expression correlations were negative, several positively correlated methylation-expression interactions were also observed, associated with CpG sites exhibiting atypical transcription start site distances and gene body localization. Methylation clustering of the tumors revealed a CpG island methylator phenotype (CIMP) subgroup associated with widespread hypermethylation, young patient age, and adverse patient outcome in a disease ...
In addition to defense against foreign DNA, the CRISPR-Cas9 system of Francisella novicida represses expression of an endogenous immunostimulatory lipoprotein. We investigated the specificity and molecular mechanism of this regulation, demonstrating that Cas9 controls a highly specific regulon of four genes that must be repressed for bacterial virulence. Regulation occurs through a protospacer adjacent motif (PAM)-dependent interaction of Cas9 with its endogenous DNA targets, dependent on a non-canonical small RNA (scaRNA) and tracrRNA. The limited complementarity between scaRNA and the endogenous DNA targets precludes cleavage, highlighting the evolution of scaRNA to repress transcription without lethally targeting the chromosome. We show that scaRNA can be reprogrammed to repress other genes, and with engineered, extended complementarity to an exogenous target, the repurposed scaRNA:tracrRNA-FnoCas9 machinery can also direct DNA cleavage. Natural Cas9 transcriptional interference likely ...
The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by ...
Balego & Associates Inc. - BalegoOnline.org EMPI® Select™ TENS Pain Control Electrotherapy Unit [199584-001] - Empi Select provides clinicians with an adjunctive, customizable pain control system for the most challenging chronic, arthritic and post-surgical pain. The flexible treatment modes, multiple pre-set programs, and treatment data collection allow you and your patients to have custom control for their complex pain. Features & Benefits Five pre-defined, body-specific settings allow patients
Balego & Associates Inc. - BalegoOnline.org EMPI® Select™ TENS Pain Control Electrotherapy Unit [199584-001] - Empi Select provides clinicians with an adjunctive, customizable pain control system for the most challenging chronic, arthritic and post-surgical pain. The flexible treatment modes, multiple pre-set programs, and treatment data collection allow you and your patients to have custom control for their complex pain. Features & Benefits Five pre-defined, body-specific settings allow patients
By using next era sequencing, they characterized the experience of most genes of the genome concurrently. Related StoriesApoE4-carrying guys with Alzheimers disease vulnerable to human brain bleedsImproved gene therapy treatment displays guarantee in mice with cystic fibrosisResearchers identify tumor suppressor genes that travel subset of melanomasA transcription element settings genetic activity in adolescent fruiting bodies The Bochum experts compared the wild-type fungus with a mutant type that has zero mature fruiting bodies, put simply struggles to reproduce sexually. For this function, they studied gene expression in youthful, immature fruiting bodies. They demonstrated that some fruiting body-specific genes arent activated in the mutant.Botox decreases discomfort and strength of spasticity carrying out a stroke Benefits from a multi-middle study demonstrates repeated treatments of botulinum toxin type A over twelve months is very well tolerated and results in a substantial reduction ...
Allergic (including atopic) and other hypersensitivity disorders are inappropriate or exaggerated immune reactions to foreign antigens. Inappropriate immune reactions include those that are misdirected against intrinsic body components, leading to .
Ramon y Cajal, searching for a neural network simpler than the brain, studied the rabbit small intestine to find interstitial cells he considered the end cells of the sympathetic nervous system (Ramon y Cajal, 1911). His drawings of what would later be called interstitial cells of Cajal, are still captivating admiration for their accuracy. The hypothesis of ICC as nerve cells was based on the observation that ICC associated with the myenteric plexus of the rabbit intestine, stained with methylene blue and silver impregnation according to the Golgi method, similar to neural tissues. Furthermore, the cells appeared to intercalate between typical nerve cells and smooth muscle cells. In the years following the publications of Cajal, morphologists studied the ICC in the gut almost continuously coming to the conclusion that they were nerve cells, Schwann cells, fibroblasts or myoid cells. Occasionally someone connected the cells with the generation of the rhythmicity of gut motor activity. Keith saw
This is the first English-language publication of the complete works of the great Spanish neurohistologist, Santiago Ramon y Cajal, on the cerebral cortex. The new translations include all Cajals very early contributions on the cortex of small mammals, relevant chapters from his definitive textbook, and all his great works on the human cerebral cortex made at the peak of his career. The book also presents Cajals surveys of cortical structure dating from his later years.
This is the first English-language publication of the complete works of the great Spanish neurohistologist, Santiago Ramon y Cajal, on the cerebral cortex. The new translations include all Cajals very early contributions on the cortex of small mammals, relevant chapters from his definitive textbook, and all his great works on the human cerebral cortex made at the peak of his career. The book also presents Cajals surveys of cortical structure dating from his later years.
Swedish University dissertations (essays) about INTERSTITIAL CELLS OF CAJAL. Search and download thousands of Swedish university dissertations. Full text. Free.
Nucleolar localization of U4 and U5 snRNAs does not depend on U6 snRNA. Fluorescein-labeled U4 or U5 snRNA were injected into the nuclei of Xenopus oocytes that
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Blackstrap molasses is one of those foods that our grandparents or parents may have used to use, but now we have pretty much exchanged it for just plain ol sugar, or golden syrup, or at a push maybe treacle.... but even that is not seen around much these days. I have been looking into some…
The results of these three studies show that dentifrices containing 1.5% arginine, an insoluble calcium compound, and fluoride have a significantly improved ability to promote remineralization and prevent demineralization of enamel relative to dentifrices containing the same level of fluoride alone. …
Make a difference with the CBS 5 News series Pay It Forward. Each week, we give away $500 to an Arizona resident who has made a difference in his or her community.
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3-end processing.
Shupyk National Medical Academy of Postgraduate Education, Kiev, Ukraine Interstitial cells of Cajal (ICC) were first discovered in 1893 in the wall of the intestine, and only after almost 100 years of interest in the ICC recovered. In addition, modern technologies have allowed to identify similar cells in other organs, in particular those that contain the muscle fibers and, accordingly, shall be subject to reduction. So, ICC was detected in the urinary tract, fallopian tubes, the seminiferous tubules etc. Further study of the functions of the ICC has established a link between human peripheral information of the bladder (neuromuscular dysfunction of bladder) and the concentration of ICC. Thus, the measurement of ICC in the bladder wall when it is dysfunction may affect the tactics of patient management in the future. Key words: interstitial cells of Cajal, neuromuscular dysfunction of bladder. References 1. Hrusha MM. 2016. Novi aspekty mizhklitynnoi vzaiemodii v stintsi kyshechnyku. Visnyk ...
We estimate the genetic contribution to southeastern England from Anglo-Saxon migrations to be under half, and identify the regions not carrying genetic material from these migrations. We suggest significant pre-Roman but post-Mesolithic movement into southeastern England from continental Europe, and show that in non-Saxon parts of the United Kingdom, there exist genetically differentiated subgroups rather than a general Celtic population ...
My guess though is that it would go deep, especially if it were more massive.. UPDATE: It turns out that considering only energy, as we are here, is not sufficient. To get a handle on the depth of the impact crater we have to turn to momentum. In the next post you will see the surprising result as the depth question is finally answered with a less toy model.. ____. * The model here is incredibly toy. I treat the plasma as an ideal gas undergoing adiabatic compression for example. I treat the tunnel as full of water rather than molten rock. Still, you learn something from even very simple models.. ...
Our bodies are created to detoxify and cleanse themselves, but there is a limit for everyone. How to cleanse your colon when you reach this toxic threshold?
All mums bodies are amazing. Whether youre using breast or bottle, your post-baby body is one super-charged powerhouse. However ... if you choose to brea

Can the mirena coil cause excessive body sweating?Can the mirena coil cause excessive body sweating?

Home › Q & A › Questions › Can the mirena coil cause.... Can the mirena coil cause excessive body sweating?. Asked. 13 Sep 2010 ... Ive had the mirena coil in for 3 weeks now when I had it fitted I got really bad cramps and after a?. Posted 13 Jun 2016 • 1 ... i have had the mirena coil in for five years and it will be took out in the next couple of days. i have gained weight severe ... Has anyone started taking Lamictal and noticed any excessive sweating and body odor?. Posted 3 Jan 2017 • 0 answers ...
more infohttps://www.drugs.com/answers/can-the-mirena-coil-cause-excessive-body-sweating-314232.html

Is the sphere organelle/coiled body a universal nuclear component?  - PubMed - NCBIIs the sphere organelle/coiled body a universal nuclear component? - PubMed - NCBI

... coiled bodies in mammalian somatic nuclei, prenucleolar bodies in nuclei assembled in vitro in Xenopus egg extract, sphere ... Is the sphere organelle/coiled body a universal nuclear component?. Gall JG1, Tsvetkov A, Wu Z, Murphy C. ... We suggest that the sphere organelle/coiled body is a "universal" nuclear component in the sense that it is involved in common ... Specifically, the sphere organelle/coiled body may be the initial site for assembly of processing complexes, which are then ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/7758244?dopt=Abstract

Gemini of coiled bodies | Disease Models & MechanismsGemini of coiled bodies | Disease Models & Mechanisms

... including dysregulated Cajal bodies and CWC22 overexpression, might promote the development of diabetic sensory polyneuropathy. ...
more infohttp://dmm.biologists.org/keyword/gemini-coiled-bodies

Garage Sale - Pro 5 Small Body Coil Over ShockGarage Sale - Pro 5' Small Body Coil Over Shock

Small Body Coil Over Shock made by Pro Shocks, for as low as $139.99. Free shipping when your order includes this part. ... Pro Shocks® new aluminum small body coil over shocks are 3 way adjustable. They are fitted aluminum coil over kit and make one ... Small Body Coil Over Shocks, 4 Inch Pol, Spring Rate-450 lbs ... Aluminum Small Body Coilover Shock, 4 Inch Plain, Spring Rate, ... Aluminum Small Body Coilover Shock, 4 Inch Plain, Spring Rate, 375 lbs ...
more infohttps://www.speedwaymotors.com/Garage-Sale-Pro-5-Small-Body-Coil-Over-Shock,64333.html

Patente US7527606 - Catheter having main body portion with coil-defined guidewire passage - Google PatentesPatente US7527606 - Catheter having main body portion with coil-defined guidewire passage - Google Patentes

The elongate main body portion has a proximal end and a distal end. The main body portion further includes a coil having at ... The elongate distal body portion extends from the distal end of the main body portion. In accordance with a further aspect of ... a guidewire lumen defined along at least a portion of a length between the distal end and the proximal end of the distal body ... least one complete turn about a central axis, the coil defining a passage along the central axis. ...
more infohttp://www.google.es/patents/US7527606?dq=flatulence

Refurbished HITACHI Large, Extra Large Flex Body/Spine MRI Coil For Sale  or Rent - DOTmed Listing #1845430Refurbished HITACHI Large, Extra Large Flex Body/Spine MRI Coil For Sale or Rent - DOTmed Listing #1845430

For Sale hitachi airis II body flex coil qd xl model MR-QFC-55 was refurbished by Medrad,please call for more info ... Extra Large Flex Body/Spine MRI Coil For Sale or Rent - DOTmed Listing #1845430: ... For Sale or Rent HITACHI Large, Extra Large Flex Body/Spine MRI Coil. *Rent : Rental Terms ... For Sale hitachi airis II body flex coil qd xl model MR-QFC-55 was refurbished by Medrad,please call for more info ...
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FreshTrends Twisted Coil - Industrial Barbell Body Jewelry - 14G 1.5 Ear Project | FreshTrends Body JewelryFreshTrends Twisted Coil - Industrial Barbell Body Jewelry - 14G 1.5 Ear Project | FreshTrends Body Jewelry

This barbell features a cool coil in t ... Flexible Body Jewelry Organic Body Jewelry Titanium Body ... FreshTrends Twisted Coil - Industrial Barbell Body Jewelry - 14G 1.5 Ear Project FreshTrends. Twisted Coil - Industrial Barbell ... Home , ON SALE: Body Jewelry & Fashion Accessories , Buy One Get One Body Jewelry , FreshTrends Twisted Coil - Industrial ... Body Jewelry Size Help. Standard Body Piercing Sizes:. These are the standard sizes used for each piercing in body jewelry. ...
more infohttps://www.freshtrends.com/cgi-bin/item/1588

EP1748814A1 - Catheter having main body portion with coil-defined guidewire passage 
        - Google PatentsEP1748814A1 - Catheter having main body portion with coil-defined guidewire passage - Google Patents

The elongate main body portion has a proximal end and a distal end. The main body portion further includes a coil having at ... The elongate distal body portion extends from the distal end of the main body portion. In accordance with a further aspect of ... a guidewire lumen defined along at least a portion of a length between the distal end and the proximal end of the distal body ... least one complete turn about a central axis, the coil defining a passage along the central axis. ...
more infohttps://patents.google.com/patent/EP1748814A1/en

Support for user`s body or part thereof > Spring containing (e.g., coil type) > Compartmentalized springs >  Patents -...Support for user`s body or part thereof > Spring containing (e.g., coil type) > Compartmentalized springs > Patents -...

Name: Beds > Support for user`s body or part thereof > Spring containing (e.g., coil type) > Compartmentalized springs. ... Coil spring assembly. Jun. 4, 2002. 6374442. Pocketed coil spring unit with combination of top and bottom sheets and inter-row ... Fiber mass with side coil insertion. Feb. 24, 2004. 6681428. Method of making pocketed coil spring unit with combination of ... Multi-stranded coil spring. Jan. 24, 2012. 8087114. Thin pocket mattress, and method and device for its manufacturing. Jan. 3, ...
more infohttp://www.patentgenius.com/class/5/655.8.html

AUTO- POSITIONING HEAD AND BODY COIL FOR MAGNETIC RE...AUTO- POSITIONING HEAD AND BODY COIL FOR MAGNETIC RE...

The auto-positioning head and body coils are positioned automaticall... ... The invention proposes a set of auto-positioning head and body coils for MRI scans. ... The invention proposes a set of auto-positioning head and body coils for MRI scans. The auto-positioning head and body coils ... Separate coils are employed for scanning different parts of the body. For example, a head coil is used for an MRI of the head ...
more infohttps://priorart.ip.com/IPCOM/000191445

Stability of measurement on apparent diffusion coefficient in benign cervical lymph nodes with the neurovascular coil or the...Stability of measurement on apparent diffusion coefficient in benign cervical lymph nodes with the neurovascular coil or the...

... the body coil.Methods Fifteen healthy volunteers underwent DWI using both 8-channel the neurovascular coil and the body coil ... no matter bilateral or lateral side.Conclusion The signals acquired whether from the neurovascular coil or from the body coil ... 10-3 mm2/s.The average value of ADC by body coil was(0.857±0.142)×10-3 mm2/s,average value of eADC was(0.432±0.057)×10-3 mm2/s. ... There was no statistically difference of the value of the ADC and eADC of lymph nodes between the two different scanning coils, ...
more infohttp://en.cnki.com.cn/Article_en/CJFDTotal-ZYXX201108013.htm

US20080161935A1 - Method for inducting weight loss using a coil for insertion into a hollow body organ 
        - Google PatentsUS20080161935A1 - Method for inducting weight loss using a coil for insertion into a hollow body organ - Google Patents

... outward force against an interior of the stomach so as to bring together two substantially opposing surfaces of the hollow body ... Method for inducting weight loss using a coil for insertion into a hollow body organ Download PDF Info. Publication number. ... US12/048,408 2006-09-01 2008-03-14 Method for inducting weight loss using a coil for insertion into a hollow body organ ... The Coil is designed to flex easily in the direction as the coil bends around the pivot pins but in the perpendicular direction ...
more infohttps://patents.google.com/patent/US20080161935A1/en

Evaluation of feasibility of 1.5 Tesla prostate MRI using body coil RF transmit in a patient with an implanted vagus nerve...Evaluation of feasibility of 1.5 Tesla prostate MRI using body coil RF transmit in a patient with an implanted vagus nerve...

Measurements were obtained along the center axis of the scanner and laterally offset by 15 cm (body coil) and 7 cm (head coil ... Measurements were obtained along the center axis of the scanner and laterally offset by 15 cm (body coil) and 7 cm (head coil ... Measurements were obtained along the center axis of the scanner and laterally offset by 15 cm (body coil) and 7 cm (head coil ... Measurements were obtained along the center axis of the scanner and laterally offset by 15 cm (body coil) and 7 cm (head coil ...
more infohttps://mayoclinic.pure.elsevier.com/en/publications/evaluation-of-feasibility-of-15-tesla-prostate-mri-using-body-coi

Sources of variation in multi-centre brain MTR histogram studies: body-coil transmission eliminates inter-centre differences  :...Sources of variation in multi-centre brain MTR histogram studies: body-coil transmission eliminates inter-centre differences :...

RESULTS: Transmission using a body coil, with a close-fitting array of surface coils for reception, gave the best uniformity. ... CONCLUSIONS: Body coil excitation is preferred for multi-centre studies. Analysis (segmentation and histogram generation) ... Sources of variation in multi-centre brain MTR histogram studies: body-coil transmission eliminates inter-centre differences ... Differences between two centres, having MR imagers from different manufacturers, were completely eliminated by using body coil ...
more infohttp://sro.sussex.ac.uk/802/

Higher order arrangement of the eukaryotic nuclear bodies | PNASHigher order arrangement of the eukaryotic nuclear bodies | PNAS

coiled body;. PML,. promyelocytic leukemia;. Gem,. Gemini of coiled bodies;. POD,. PML body;. RRM,. RNA-recognition motif;. ... Among the known nuclear bodies are the Cajal body or coiled body (CB; ref. 3 and references therein), the promyelocytic ... Of these nuclear bodies, the Gemini of coiled bodies (GEM) seems to associate with TB through the interaction between survival ... 2 and references therein), the GEM body (7), and the more recently identified matrix-associated deacetylase body (8), HAP body ...
more infohttps://www.pnas.org/content/99/21/13583?ijkey=d55faf1e30eb6ab98e126b95721300bb5a0ba16b&keytype2=tf_ipsecsha

China Tattoo Equipment Accessory, China Tattoo Equipment Accessory Manufacturers and Suppliers on Alibaba.comChina Tattoo Equipment Accessory, China Tattoo Equipment Accessory Manufacturers and Suppliers on Alibaba.com

new style tattoo coil with cloth body accessories tattoo machine coils US $2.3-2.9 / Piece ... 2.powerful and fit for all professional tattoo machines 3.Top quality with attractive price core height 28mm Coils 8 wrap ...
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Patent US6157193 - MR imaging system with electrically insulated coil element - Google PatentsPatent US6157193 - MR imaging system with electrically insulated coil element - Google Patents

... unit and at least one electrically completely insulated second coil element which is magnetically coupled to the first coil ... An MR imaging system with an electrically insulated coil element includes at least one first coil element which is electrically ... They prevent the formation of dangerous eddy currents in the patients body regions near the coil by limiting the coil currents ... a second RF coil is also used. The second RF coil is electrically completely insulated from the surroundings. The two coils are ...
more infohttp://www.google.com/patents/US6157193?dq=6011510

Used - Used DVDs - Record Shop XUsed - Used DVD's - Record Shop X

Lacuna Coil : Visual karma (body, mind and soul) -2-dvd + audio dvd + cd In stock, shipping immediately ...
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Multiple System Atrophy Treatment & Management: Approach Considerations, Nonpharmacologic Treatment of Hypotension and...Multiple System Atrophy Treatment & Management: Approach Considerations, Nonpharmacologic Treatment of Hypotension and...

Tufted astrocytes, coiled bodies. Membrane. No limiting membrane; tubular profiles and electrodense granules ... Diffuse Lewy body disease presenting as multiple system atrophy. Can J Neurol Sci. 1999 May. 26(2):127-31. [Medline]. ... U.S Body Says Gene Therapy May Be More Cost Effective for Spinal Muscular Atrophy ... Dopamine cell loss in the periaqueductal gray in multiple system atrophy and Lewy body dementia. Neurology. 2009 Jul 14. 73(2): ...
more infohttps://emedicine.medscape.com/article/1154583-treatment

Multiple System Atrophy Workup: Approach Considerations, MRI, PET ScanningMultiple System Atrophy Workup: Approach Considerations, MRI, PET Scanning

Tufted astrocytes, coiled bodies. Membrane. No limiting membrane; tubular profiles and electrodense granules ... Diffuse Lewy body disease presenting as multiple system atrophy. Can J Neurol Sci. 1999 May. 26(2):127-31. [Medline]. ... Dopamine cell loss in the periaqueductal gray in multiple system atrophy and Lewy body dementia. Neurology. 2009 Jul 14. 73(2): ... Presynaptic and postsynaptic; dopaminergic cell bodies in substantia nigra and their terminals in striatum, as well as their ...
more infohttps://emedicine.medscape.com/article/1154583-workup

The relationship between SMN, the spinal muscular atrophy protein, and nuclear coiled bodies in differentiated tissues and...The relationship between SMN, the spinal muscular atrophy protein, and nuclear coiled bodies in differentiated tissues and...

... and nuclear coiled bodies in differentiated tissues and cultured cells is an eagle-i resource of type Journal article at eagle- ... The relationship between SMN, the spinal muscular atrophy protein, and nuclear coiled bodies in differentiated tissues and ...
more infohttp://shared.eagle-i.net/i/00000140-d762-6724-fa61-b3d480000000

JCI -
Lentivector-mediated SMN replacement in a mouse model of spinal muscular atrophyJCI - Lentivector-mediated SMN replacement in a mouse model of spinal muscular atrophy

... which often colocalize with coiled bodies (16). In tissues and cells from type I SMA patients SMN levels are severely reduced ... we have generated lentivector expressing human SMN and successfully used it to restore gemini of coiled bodies (gems) in type I ... gemini of coiled bodies; MN, motor neuron; SMA, spinal muscular atrophy; SMN, survival motor neuron. ... P2 was chosen because this day was prior to the point of MN cell body loss in the SMA mice (13). One week after injection of ...
more infohttps://www.jci.org/articles/view/22922

Patent US9358120 - Expandable coil spinal implant - Google PatentsPatent US9358120 - Expandable coil spinal implant - Google Patents

... vertebral body, and spinal motion segment replacement or reconstruction comprise a plurality of loops and spaces between the ... The coiled implants include one or more balloons within the hollow center, the spaces between the coil loops, and/or within the ... Filling the balloon expands the loops and thereby increases the height of the coil. Bone graft material or bone cement may be ... removing the expandable coil from the vertebral body or intervertebral space. The coil may be removed from the vertebral body ...
more infohttp://www.google.co.uk/patents/US9358120

Kiseki Purple Heart NS Moving Coil Phono Cartridge The sound of sonic art. Review By Tom LyleKiseki Purple Heart NS Moving Coil Phono Cartridge The sound of sonic art. Review By Tom Lyle

... of Enjoy the Music.coms Superior ... Coil Body: Pure iron. Weight: 7 grams. Output Voltage: 0.48 mV at 5 cm/s. Internal Impedance: 42 Ohms. Frequency Response: 20- ... Type: Moving coil (MC) stereo photo cartridge. Body: Purple Heart Wood. Cartridge Length: 30 mm Cantilever: Solid boron rod. ... Kiseki Purple Heart NS Moving Coil Phono Cartridge. The sound of sonic art.. Review By Tom Lyle ...
more infohttp://www.enjoythemusic.com/superioraudio/equipment/0715/Kiseki_Purple_Heart_NS_Moving_Coil_Phono_Cartridge_Review.htm
  • Subtle alterations in spliceosome structure and function in diabetic sensory neurons, including dysregulated Cajal bodies and CWC22 overexpression, might promote the development of diabetic sensory polyneuropathy. (biologists.org)
  • In some embodiments, the transmit coils are oriented to generate an RF magnetic field in directions substantially orthogonal to a static gradient field, and the receive coils are oriented to sense RF EPR signal in directions substantially orthogonal to the transmitted field and to the static field, to minimize coupling of the transmitted signal to the receive coils. (google.de)
  • The next step to perform state of the art cardiovascular whole body imaging is to implement it to high field strength like 3 Tesla. (ismrm.org)
  • The combination of matrix-coil systems, parallel imaging and 3 Tesla offer the possibility to image the entire cardiovascular system within reasonable time at high image quality. (ismrm.org)
  • MR (3 Tesla) without endorectal coil consisted of axial T2w and DWI sequences for prostate and tumour delineation, and 3D-CISS sequence for optimal fiducial identification and CT-MR registration (see figure 1). (thefreedictionary.com)
  • They are made of steel coil springs to support the body and give the matress a bouncing effect. (newsmax.com)
  • Are you ready to switch out your cranky old springs for some high performance Audi A6 Coil Springs? (autoanything.com)
  • Furthermore, since these types of spring guides are constructed as coil springs, the wire of the helices thereof may become broken due to inadvertent over stressings or distortions, thus requiring the presence of a so-called safety wire that extends the full length of the guide and whose only function is to prevent the separation of parts in the event of coil breakage. (google.com.au)
  • The coiled implants include one or more balloons within the hollow center, the spaces between the coil loops, and/or within the central void that the coil surrounds. (google.co.uk)
  • Filling the balloon expands the loops and thereby increases the height of the coil. (google.co.uk)
  • The disclosure relates generally to spinal implants, and in particular, to implants configured as an expandable coil with a balloon interspersed between or within the loops of the coil, which when inflated with a fluid expands the coil to facilitate spinal reconstruction, particularly when needed to correct lesions or diseases of the vertebral body, a disc, and at least one spinal motion segment, also known as a functional spinal unit. (google.co.uk)
  • The loops are supported by a coiled support member and are locked within the coiled support member by a wire retainer. (google.ca)
  • These coils are often single or multi-turn loops which are placed directly over the anatomy of interest. (wikipedia.org)
  • 9 A6lm 25/00 128/2 M Int. he core comprises, proximal and distal portions in which the distal portion may be relatively more flexible than the proximal portion and corresponds in length to the distal portion of the body spring. (google.com.au)
  • Moreover, RF power from body coil transmit at distances greater than 32 cm from isocenter was found to be lower than from the RF power from head coil transmit measured at locations adjacent to the coil array at its opening. (elsevier.com)
  • at least one hollow, tubular connector member, adjacent ones of said coil segments being connected together by said connector member, said connector member being detachable from selected portions of said coil segments by application of energy to said connector member. (google.com)
  • The heat activation member typically can be advanced axially through or over the coil assembly, and currently preferably comprises a fiber optic, although the heat activation member can also comprise a heat pipe, or a device for generating heat by RF energy or electrical resistance. (google.com)
  • Through the analysis of TDP, a protein functional in both transcriptional repression and alternative splicing, we have identified a new category of nuclear bodies within which the TDP molecules reside. (pnas.org)
  • As these data are limited to the dynamically distributed PML protein, we chose to focus on providing a role for the PML-containing nuclear body itself. (pnas.org)
  • Immunohistochemical analysis demonstrates the PML-containing nuclear body to be composed of at least four proteins, including PML, PML-associated factor (PAF31) (J. D. Chen and R.M.E., unpublished data), the SP-100 autoantigen of primary biliary cirrhosis, and the nuclear matrix protein NDP55 ( 20 - 23 ). (pnas.org)
  • The N-terminus of the coilin protein directs its self-oligomerization while the C-terminus influences the number of nuclear bodies assembled per cell. (bio-rad.com)
  • 1 Here we show that CHMP2B (charged multivesicular body protein 2B), a gene that was recently shown to be linked to FTD, 2 was altered in two unrelated patients with ALS-spectrum disorders. (neurology.org)
  • The connector members are currently preferably hollow, tubular connector members that are advantageously detachable from selected portions of the coil segments by application of energy to one or more selected connector members. (google.com)
  • A filament for irradiating a living body has a core material capable of irradiating radioactive radiation clad in a tubular casing of protective material different from the material forming the core. (google.ca)
  • These tubular lower control arms are a perfect fit for your 1st or 2nd Generation F-Body vehicle. (classicindustries.com)
  • We present evidence for the essential homology of four nuclear organelles that have previously been described under four different names: coiled bodies in mammalian somatic nuclei, prenucleolar bodies in nuclei assembled in vitro in Xenopus egg extract, sphere organelles in amphibian germinal vesicles (GVs), and Binnenkörper in insect GVs. (nih.gov)
  • Our data suggest the existence of a hierarchy and possibly functional arrangement of the nuclear bodies within the eukaryotic nuclei. (pnas.org)
  • Therefore, an object of this invention is to provide a spring guide having a body formed as a continuous coiled spring with the helices thereof in contact with each other and including a flexible distal tip portion so constructed as to minimize the possibility of kinking when undergoing either axially applied compression loads or sharply applied angular loads. (google.com.au)
  • The present invention provides an apparatus and a corresponding method useful for electron paramagnetic resonance imaging, in situ and in vivo, using high-isolation transmit/receive (TX/RX) coils, which, in some embodiments, provide microenvironmental images that are representative of particular internal. (google.de)
  • The method also involves exerting an outward force against an interior of the stomach so as to bring together two substantially opposing surfaces of the hollow body by placing the member in its deployed position. (google.com)
  • The support structure includes an elastic body, such as a spring, for applying to the container or to the transducer a substantially constant force to press together the transducer and the wall. (google.co.uk)
  • d) at least one elastic body for applying to the second holder the substantially constant force to press the wall against the transducer. (google.co.uk)
  • In accordance with a further aspect of the invention, the distal body portion has a proximal end and a distal end and can include a guidewire lumen defined along at least a portion of a length between the distal end and the proximal end of the distal body portion. (google.es)
  • 8. A coil system in accordance with claim 1 further comprising at least one switch configured to switch between the scan mode of operation and the calibration mode of operation. (google.com)
  • ref. 3 and references therein), the promyelocytic leukemia (PML) body or POD (ref. 6 and references therein), a class of splicing-related bodies including the SC35 speckles or interchromatin granule cluster (ref. 2 and references therein), the GEM body ( 7 ), and the more recently identified matrix-associated deacetylase body ( 8 ), HAP body ( 9 ), and nucleoli-associated paraspeckles ( 10 ). (pnas.org)
  • They are fitted aluminum coil over kit and make one of the cleanest coil overs on the market for your street rod. (speedwaymotors.com)
  • These billet-aluminum spindles and steering arms are direct-replacement components for popular GM A-, F-, and X-body muscle cars from 1964 to 1972. (classicindustries.com)
  • They consist of two electromagnetic coils, the transmitter and receiver, which generate the field and receive the resulting signal. (wikipedia.org)
  • Spring coil mattresses don't provide as much relief to the body's vital pressure points as foam mattresses do. (newsmax.com)
  • We suggest that the sphere organelle/coiled body is a "universal" nuclear component in the sense that it is involved in common nuclear processes and hence will be found in one form or another in most eukaryotic cells. (nih.gov)
  • A nuclear body refers to any of the prominent non-membraned structures in the nucleus of the eukaryotic cell. (biology-online.org)
  • However, for most nuclear bodies, the details of involvement in these processes in relation to their three-dimensional distributions in the nucleus are still unclear. (pnas.org)
  • Has anyone started taking Lamictal and noticed any excessive sweating and body odor? (drugs.com)
  • Although the electromagnetic fields produced by the transmitting coil are in the RF range of tens of megahertz (often in the shortwave radio portion of the electromagnetic spectrum) at powers usually exceeding the highest powers used by amateur radio, there is very little RF interference produced by the MRI machine. (wikipedia.org)
  • The RF frequency electromagnetic field produced in the "transmitting coil" is a magnetic near-field with very little associated changing electric field component (such as all conventional radio wave transmissions have). (wikipedia.org)
  • Thus, the high-powered electromagnetic field produced in the MRI transmitter coil does not produce much electromagnetic radiation at its RF frequency, and the RF power is confined to the coil space and not radiated as "radio waves. (wikipedia.org)
  • The receiver coil picks up the RF electromagnetic radiation produced by nuclear relaxation inside the subject. (wikipedia.org)
  • For example, a head coil is used for an MRI of the head and neck area and a body coil is used for a scan of the spine. (ip.com)
  • For example, the coil settings need to be changed if both the spine and pelvic area need to be scanned for a patient. (ip.com)
  • Generally refers to a straight line (the spine) that the upper body rotates around in the course of the golf swing. (pga.com)
  • Is the sphere organelle/coiled body a universal nuclear component? (nih.gov)
  • Specifically, the sphere organelle/coiled body may be the initial site for assembly of processing complexes, which are then sorted to other places in the nucleus, where the actual RNA processing takes place. (nih.gov)
  • It is a double-membraned organelle containing nuclear structures, e.g. chromatin and nuclear bodies. (biology-online.org)
  • Results: B1 field measurements demonstrated greater than 10 dB reduction in RF power at distances beyond 28 cm and 24 cm from isocenter for body and head coil, respectively. (elsevier.com)
  • Conclusions: For the particular scanner model evaluated in this study, positioning an implanted VNS farther than 32 cm from isocenter (configuration achievable for prostate exams) can reduce risks of RF-heating resulting from the body coil transmit to those associated with using a T/R head coil. (elsevier.com)
  • Subsequently, the upper half of the coil is put in place and the coil is land marked. (ip.com)
  • The 2D-matrix may also allow for the traceability of a finished part back to the coil it was blanked and subsequently formed from. (patents.com)
  • The invention proposes a set of auto-positioning head and body coils for MRI scans. (ip.com)
  • The auto-positioning head and body coils are positioned automatically on the patient without an operator manually placing the coils. (ip.com)
  • In MRI scans, head and body examination takes up more than 60 percent scan time. (ip.com)
  • The invention provides an auto-positioning head and body coils system employed in an MRI scanner. (ip.com)
  • As shown in Figure 1, the auto-positioning head coil is set on the rear side of the magnetic bore of the MRI scanner. (ip.com)
  • The auto-positioning head coil moves automatically to the is. (ip.com)
  • Purpose: To assess risks of RF-heating of a vagus nerve stimulator (VNS) during 1.5 T prostate MRI using body coil transmit and to compare these risks with those associated with MRI head exams using a transmit/receive head coil. (elsevier.com)
  • Measurements were obtained along the center axis of the scanner and laterally offset by 15 cm (body coil) and 7 cm (head coil). (elsevier.com)
  • The spring coil mattresses provide a bouncy and springy effect, while foam mattresses provide a cushiony feel from head to toe with a touch of firmness underneath. (newsmax.com)
  • Part #MR-QHC-51 MRP-7000 Quad Head Coil, part interchangeable with MR-QHC-52 and. (dotmed.com)
  • coil 5-inch strip to make head. (pastrywiz.com)
  • The cardinal only stood there and looked up at the naga as the coils gripped him, snugging up to his neck, forcing his head in an upright position to stare up at the naga. (deviantart.com)
  • The full-sized mattress conforms to your body as you rest to provide exceptional support. (parenting.com)
  • A marking system for a rolled metal coil to provide markings containing data about material properties within the metal proximate the markings. (patents.com)
  • A monitoring device may be configured to provide material property data of metal during formation of a coil. (patents.com)
  • A controller may be programmed to, in response to receiving the data, utilize the marking device to provide the 2D-matrix containing the material property data on the coil proximate a location of the material property. (patents.com)
  • The two types of mattresses that have been declared the most comfortable are the spring coil mattress and the foam mattress. (newsmax.com)
  • The question then arises why foam mattress, or why coil mattress. (newsmax.com)
  • Tossing and turning while sleeping on a foam mattress will not wake up a partner, unlike on a spring coil mattress. (newsmax.com)
  • In the case of spring coil mattress, the level of comfort goes down within a year's usage, whereas the comfort level of the foam mattress remains intact after years of usage. (newsmax.com)
  • As far as firmness is concerned, spring coil mattresses act as excellent shock absorbers that in turn prevent quick tear of the mattress. (newsmax.com)
  • Generally, the above described process of placing the coils appropriately takes approximately five minutes before the value scan time begins. (ip.com)
  • Preoperative investigation of anal fistulas with body coil MRI and high frequency endoanal ultrasound. (diva-portal.org)
  • Recent developments in MR hard- and software made it possible to perform whole body MRI at the same high image quality as it is known from organ based MR exams. (ismrm.org)
  • Multiparametric MRI (mpMRI), incorporating morphologic T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and dynamic contrast-enhanced (DCE) imaging of the prostate with high field strength (3 T) without an endorectal coil , showed a prostatic mass invading the lower left portion of the bladder, the anterior rectal wall, and both obturator muscles (Figure 1). (thefreedictionary.com)